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Sample records for anisotropic apoptosis initiation

  1. Diffusion is capable of translating anisotropic apoptosis initiation into a homogeneous execution of cell death.

    LENUS (Irish Health Repository)

    Huber, Heinrich J

    2010-01-01

    ABSTRACT: BACKGROUND: Apoptosis is an essential cell death process throughout the entire life span of all metazoans and its deregulation in humans has been implicated in many proliferative and degenerative diseases. Mitochondrial outer membrane permeabilisation (MOMP) and activation of effector caspases are key processes during apoptosis signalling. MOMP can be subject to spatial coordination in human cancer cells, resulting in intracellular waves of cytochrome-c release. To investigate the consequences of these spatial anisotropies in mitochondrial permeabilisation on subsequent effector caspase activation, we devised a mathematical reaction-diffusion model building on a set of partial differential equations. RESULTS: Reaction-diffusion modelling suggested that even if strong spatial anisotropies existed during mitochondrial cytochrome c release, these would be eliminated by free diffusion of the cytosolic proteins that instantiate the apoptosis execution network. Experimentally, rapid sampling of mitochondrial permeabilisation and effector caspase activity in individual HeLa cervical cancer cells confirmed predictions of the reaction-diffusion model and demonstrated that the signalling network of apoptosis execution could efficiently translate spatial anisotropies in mitochondrial permeabilisation into a homogeneous effector caspase response throughout the cytosol. Further systems modelling suggested that a more than 10,000-fold impaired diffusivity would be required to maintain spatial anisotropies as observed during mitochondrial permeabilisation until the time effector caspases become activated. CONCLUSIONS: Multi-protein diffusion efficiently contributes to eliminating spatial asynchronies which are present during the initiation of apoptosis execution and thereby ensures homogeneous apoptosis execution throughout the entire cell body. For previously reported biological scenarios in which effector caspase activity was shown to be targeted selectively to

  2. Effect of initial stress on reflection at the free surface of anisotropic ...

    Indian Academy of Sciences (India)

    The propagation of plane waves is considered in a general anisotropic elastic medium in the presence of initial stress. The Christoffel equations are solved into a polynomial of degree six. The roots of this polynomial represent the vertical slowness values for the six quasi-waves resulting from the presence of a discontinuity ...

  3. Reverse engineering of heavy-ion collisions: Unraveling initial conditions from anisotropic flow data

    International Nuclear Information System (INIS)

    Retinskaya, Ekaterina

    2014-01-01

    Ultra-Relativistic heavy-ion physics is a promising field of high energy physics connecting two fields: nuclear physics and elementary particle physics. Experimental achievements of the last years have provided an opportunity to study the properties of a new state of matter created in heavy-ion collisions called quark-gluon plasma. The initial state of two colliding nuclei is affected by fluctuations coming from wave- functions of nucleons. These fluctuations lead to the momentum anisotropy of the hadronic matter which is observed by the detectors. The system created in the collision behaves like a fluid, so the initial state is connected to the final state via hydrodynamic evolution. In this thesis we model the evolution with relativistic viscous hydrodynamics. Our results, combined with experimental data, give non trivial constraints on the initial state, thus achieving 'reverse engineering' of the heavy-ion collisions. The observable which characterizes the momentum anisotropy is the anisotropic flow v n . We present the first measurements of the first harmonic of the anisotropic flow called directed flow v 1 in Pb-Pb collisions at the LHC. We then perform the first viscous hydrodynamic modeling of directed flow and show that it is less sensitive to viscosity than higher harmonics. Comparison of these experimental data with the modeling allows to extract the values of the dipole asymmetry of the initial state, which provides constraints on the models of initial states. A prediction for directed flow v 1 in Au-Au collisions is also made for RHIC. We then perform a similar modeling of the second and third harmonics of the anisotropic flow, called respectively elliptic v 2 and triangular v 3 flow. A combined analysis of the elliptic and triangular flow data compared with viscous hydrodynamic calculations allows us to put constraints on initial ellipticity and triangularity of the system. These constraints are then used as a filter for different models of

  4. Intestinal epithelial apoptosis initiates gross bowel necrosis in an experimental rat model of neonatal necrotizing enterocolitis.

    Science.gov (United States)

    Jilling, Tamas; Lu, Jing; Jackson, Michele; Caplan, Michael S

    2004-04-01

    The histopathology of necrotizing enterocolitis (NEC) is characterized by destruction of the mucosal layer in initial stages and by transmural necrosis of the intestinal wall in advanced stages of the disease. To test the hypothesis that enhanced epithelial apoptosis is an initial event underlying the gross histologic changes, we analyzed epithelial apoptosis and tissue morphology in an animal model of NEC and evaluated the effect of caspase inhibition on the incidence of experimental NEC in this model. Apoptosis was analyzed with terminal deoxynucleotidyltransferase-mediated dUTP-FITC nick end labeling (TUNEL) staining in intestinal sections and by measuring caspase 3 activity from intestinal lysates of neonatal rats subjected to formula feeding and cold/asphyxia stress (FFCAS) and from mother-fed (MF) controls. Morphologic evaluation was based on hematoxylin and eosin staining of intestinal sections. FFCAS resulted in histologic changes consistent with NEC, which were absent from MF animals. FFCAS was also associated with a significantly increased rate of nuclear DNA fragmentation in the small intestinal epithelium compared with MF. Elevated tissue caspase 3 activity confirmed the presence of apoptosis in samples with increased DNA fragmentation. Analysis of the coincidence of morphologic damage and apoptosis in corresponding tissue sections indicated that apoptosis precedes gross morphologic changes in this model. Furthermore, supplementation of formula with 8 boc-aspartyl(OMe)-fluoromethylketone, a pan-caspase inhibitor, significantly reduced the incidences of apoptosis and experimental NEC. These findings indicate that in neonatal rats FFCAS induces epithelial apoptosis that serves as an underlying cause for subsequent gross tissue necrosis.

  5. Radiation induced apoptosis and initial DNA damage are inversely related in locally advanced breast cancer patients

    International Nuclear Information System (INIS)

    Pinar, Beatriz; Henríquez-Hernández, Luis Alberto; Lara, Pedro C; Bordon, Elisa; Rodriguez-Gallego, Carlos; Lloret, Marta; Nuñez, Maria Isabel; De Almodovar, Mariano Ruiz

    2010-01-01

    DNA-damage assays, quantifying the initial number of DNA double-strand breaks induced by radiation, have been proposed as a predictive test for radiation-induced toxicity. Determination of radiation-induced apoptosis in peripheral blood lymphocytes by flow cytometry analysis has also been proposed as an approach for predicting normal tissue responses following radiotherapy. The aim of the present study was to explore the association between initial DNA damage, estimated by the number of double-strand breaks induced by a given radiation dose, and the radio-induced apoptosis rates observed. Peripheral blood lymphocytes were taken from 26 consecutive patients with locally advanced breast carcinoma. Radiosensitivity of lymphocytes was quantified as the initial number of DNA double-strand breaks induced per Gy and per DNA unit (200 Mbp). Radio-induced apoptosis at 1, 2 and 8 Gy was measured by flow cytometry using annexin V/propidium iodide. Radiation-induced apoptosis increased in order to radiation dose and data fitted to a semi logarithmic mathematical model. A positive correlation was found among radio-induced apoptosis values at different radiation doses: 1, 2 and 8 Gy (p < 0.0001 in all cases). Mean DSB/Gy/DNA unit obtained was 1.70 ± 0.83 (range 0.63-4.08; median, 1.46). A statistically significant inverse correlation was found between initial damage to DNA and radio-induced apoptosis at 1 Gy (p = 0.034). A trend toward 2 Gy (p = 0.057) and 8 Gy (p = 0.067) was observed after 24 hours of incubation. An inverse association was observed for the first time between these variables, both considered as predictive factors to radiation toxicity

  6. Anisotropic flow from Non-equilibrium initial condition with a saturation scale

    International Nuclear Information System (INIS)

    Greco, V.; Plumari, S.; Puglisi, A.; Ruggieri, M.; Scardina, F.

    2014-01-01

    A current goal of relativistic heavy ion collisions experiments is the understanding of the impact of initial non-equilibrium on final observables. A Color Glass Condensate (CGC) as the limiting state of QCD matter at very high density implies initial non-thermal distribution at least for momenta below the saturation scale. In viscous hydrodynamics simulations, a standard Glauber initial condition leads to estimate 4πη/s ∼ 1, while employing the Kharzeev-Levin-Nardi (KLN) modeling of the CGC leads to at least a factor of 2 larger η/s. Within a kinetic theory approach based on a relativistic Boltzmann-like transport simulation, our main result is that the out-of-equilibrium initial distribution in p-space reduces the efficiency in building-up the elliptic flow. At RHIC energy we find the available data on ν 2 are in agreement with a 4πη/s ∼ 1 also for KLN initial conditions. (authors)

  7. Granzyme B (GraB) Autonomously Crosses the Cell Membrane and Perforin Initiates Apoptosis and GraB Nuclear Localization

    OpenAIRE

    Shi, Lianfa; Mai, Sabine; Israels, Sara; Browne, Kylie; Trapani, Joseph A.; Greenberg, Arnold H.

    1997-01-01

    Granzyme B (GraB) induces apoptosis in the presence of perforin. Perforin polymerizes in the cell membrane to form a nonspecific ion pore, but it is not known where GraB acts to initiate the events that ultimately lead to apoptosis. It has been hypothesized that GraB enters the target cell through a perforin channel and then initiates apoptosis by cleaving and activating members of the ICE/Ced-3 family of cell death proteases. To determine if GraB can enter the cell, we treated YAC-1 or HeLa ...

  8. Berberine-induced apoptosis in human prostate cancer cells is initiated by reactive oxygen species generation

    International Nuclear Information System (INIS)

    Meeran, Syed M.; Katiyar, Suchitra; Katiyar, Santosh K.

    2008-01-01

    Phytochemicals show promise as potential chemopreventive or chemotherapeutic agents against various cancers. Here we report the chemotherapeutic effects of berberine, a phytochemical, on human prostate cancer cells. The treatment of human prostate cancer cells (PC-3) with berberine induced dose-dependent apoptosis but this effect of berberine was not seen in non-neoplastic human prostate epithelial cells (PWR-1E). Berberine-induced apoptosis was associated with the disruption of the mitochondrial membrane potential, release of apoptogenic molecules (cytochrome c and Smac/DIABLO) from mitochondria and cleavage of caspase-9,-3 and PARP proteins. This effect of berberine on prostate cancer cells was initiated by the generation of reactive oxygen species (ROS) irrespective of their androgen responsiveness, and the generation of ROS was through the increased induction of xanthine oxidase. Treatment of cells with allopurinol, an inhibitor of xanthine oxidase, inhibited berberine-induced oxidative stress in cancer cells. Berberine-induced apoptosis was blocked in the presence of antioxidant, N-acetylcysteine, through the prevention of disruption of mitochondrial membrane potential and subsequently release of cytochrome c and Smac/DIABLO. In conclusion, the present study reveals that the berberine-mediated cell death of human prostate cancer cells is regulated by reactive oxygen species, and therefore suggests that berberine may be considered for further studies as a promising therapeutic candidate for prostate cancer

  9. S-wave propagating in an anisotropic inhomogeneous elastic medium under the influence of gravity, initial stress, electric and magnetic field

    Directory of Open Access Journals (Sweden)

    Kakar Rajneesh

    2014-01-01

    Full Text Available The purpose of this paper is to study the effect of gravity, initial stress, non-homogeneity, electric and magnetic field on the propagation of shear waves in an anisotropic incompressible medium. Various graphs are plotted to show the effect of direction of propagation, the anisotropy, magnetic field, electric field, non-homogeneity of the medium and the initial stress on shear waves. The dispersion equations for shear waves are obtained and discussed for different cases. In fact, in the absence of various material parameters, these equations are in agreement with the classical results for isotropic medium.

  10. Analysis of Residual DSBs in Ataxia-Telangiectasia Lymphoblast Cells Initiating Apoptosis

    Directory of Open Access Journals (Sweden)

    Teresa Anglada

    2016-01-01

    Full Text Available In order to examine the relationship between accumulation of residual DNA double-strand breaks (DSBs and cell death, we have used a control and an ATM (Ataxia-Telangiectasia Mutated defective cell line, as Ataxia-Telangiectasia (AT cells tend to accumulate residual DSBs at long times after damage infliction. After irradiation, AT cells showed checkpoint impairment and a fraction of cells displayed an abnormal centrosome number and tetraploid DNA content, and this fraction increased along with apoptosis rates. At all times analyzed, AT cells displayed a significantly higher rate of radiation-induced apoptosis than normal cells. Besides apoptosis, 70–85% of the AT viable cells (TUNEL-negative carried ≥10 γH2AX foci/cell, while only 12–27% of normal cells did. The fraction of AT and normal cells undergoing early and late apoptosis were isolated by flow cytometry and residual DSBs were concretely scored in these populations. Half of the γH2AX-positive AT cells undergoing early apoptosis carried ≥10 γH2AX foci/cell and this fraction increased to 75% in late apoptosis. The results suggest that retention of DNA damage-induced γH2AX foci is an indicative of lethal DNA damage, as cells undergoing apoptosis are those accumulating more DSBs. Scoring of residual γH2AX foci might function as a predictive tool to assess radiation-induced apoptosis.

  11. Eukaryotic initiation factor 3C silencing inhibits cell proliferation and promotes apoptosis in human glioma.

    Science.gov (United States)

    Hao, Jinmin; Wang, Zhiming; Wang, Yaowu; Liang, Zhaohui; Zhang, Xin; Zhao, Zongmao; Jiao, Baohua

    2015-06-01

    Eukaryotic initiation factor 3, subunit c (eIF3c), an oncogene overexpressed in human cancers, plays an important role in cell tumorigenesis and proliferation. However, studies assessing its function in gliomas are scarce. The present study evaluated for the first time, the role of eIF3c in gliomas. Immunohistochemistry was carried out to assess eIF3c expression in 95 human glioma samples and normal brain tissues. Then, the eIF3c mRNA levels were detected in tumor and normal brain specimens by quantitative RT-PCR. In addition, eIF3c mRNA levels were assessed in four glioma cell lines (U87, U251, A172 and U373) by semi-quantitative RT-PCR. The RNA interference (RNAi) technology was employed to knock down the eIF3c gene in the U251 cells. Western blot analysis, BrdU assay and flow cytometry were used to measure eIF3c protein levels, cell proliferation, cell apoptosis and cell cycle, respectively. The eIF3c protein was overexpressed in the human glioma specimens. In agreement, the eIF3c mRNA expression levels were significantly higher in the human glioma tissues compared with the normal brain samples (Pcell lines. Silencing the eIF3c gene in the U251 cells by RNAi significantly suppressed cell proliferation (Pcell number (Pcells were significantly increased (P<0.01) after eIF3c knockdown. These findings suggest that eIF3c is overexpressed in human gliomas and essential for their proliferation and survival. Therefore, inhibiting eIF3c expression may constitute an effective therapy for human glioma.

  12. RhoB promotes cancer initiation by protecting keratinocytes from UVB-induced apoptosis but limits tumor aggressiveness.

    Science.gov (United States)

    Meyer, Nicolas; Peyret-Lacombe, Alexis; Canguilhem, Bruno; Médale-Giamarchi, Claire; Mamouni, Kenza; Cristini, Agnese; Monferran, Sylvie; Lamant, Laurence; Filleron, Thomas; Pradines, Anne; Sordet, Olivier; Favre, Gilles

    2014-01-01

    The role of UVB-induced apoptosis in the formation of squamous cell carcinoma (SCC) is recognized. We previously identified the small RhoB (Ras homolog gene family, member B) GTPase, an early response gene to cellular stress, as a critical protein controlling apoptosis of human keratinocytes after UVB exposure. Here we generated SKH1 (hairless immunocompetent mouse) mice invalidated for RhoB to evaluate its role in UVB-induced skin carcinogenesis in vivo. We show that rhob-/- mice have a lower risk of developing UVB-induced keratotic tumors and actinic keratosis that is associated with a higher sensitivity of UVB-exposed keratinocytes to apoptosis. We extend this observation to primary cultures of normal human keratinocytes in which RhoB was downregulated with small interfering RNA (siRNA) and further show that the hypersensitivity to apoptosis depends on B-cell lymphoma 2 (Bcl-2) downregulation. In rhob-/- mice, the UVB-induced tumors were preferentially undifferentiated and highly proliferative. Finally, we show in humans an almost constant loss of RhoB expression in undifferentiated SCCs. These undifferentiated and RhoB-deficient tumors have elevated phosphorylated histone H2AX (γH2AX) and 53BP1, two markers of DNA double-strand breaks. Together, our results indicate that UVB-induced RhoB expression participates in in vivo SCC initiation by increasing keratinocyte survival. Conversely, RhoB may limit tumor aggressiveness as loss of RhoB expression in tumor cells is associated with tumor progression.

  13. Material Induced Anisotropic Damage

    NARCIS (Netherlands)

    Niazi, Muhammad Sohail; Wisselink, H.H.; Meinders, Vincent T.; van den Boogaard, Antonius H.; Hora, P.

    2012-01-01

    The anisotropy in damage can be driven by two different phenomena; anisotropic defor-mation state named Load Induced Anisotropic Damage (LIAD) and anisotropic (shape and/or distribution) second phase particles named Material Induced Anisotropic Damage (MIAD). Most anisotropic damage models are based

  14. Anisotropic universe with anisotropic sources

    Science.gov (United States)

    Aluri, Pavan K.; Panda, Sukanta; Sharma, Manabendra; Thakur, Snigdha

    2013-12-01

    We analyze the state space of a Bianchi-I universe with anisotropic sources. Here we consider an extended state space which includes null geodesics in this background. The evolution equations for all the state observables are derived. Dynamical systems approach is used to study the evolution of these equations. The asymptotic stable fixed points for all the evolution equations are found. We also check our analytic results with numerical analysis of these dynamical equations. The evolution of the state observables are studied both in cosmic time and using a dimensionless time variable. Then we repeat the same analysis with a more realistic scenario, adding the isotropic (dust like dark) matter and a cosmological constant (dark energy) to our anisotropic sources, to study their co-evolution. The universe now approaches a de Sitter space asymptotically dominated by the cosmological constant. The cosmic microwave background anisotropy maps due to shear are also generated in this scenario, assuming that the universe contains anisotropic matter along with the usual (dark) matter and vacuum (dark) energy since decoupling. We find that they contribute dominantly to the CMB quadrupole. We also constrain the current level of anisotropy and also search for any cosmic preferred axis present in the data. We use the Union 2 Supernovae data to this extent. An anisotropy axis close to the mirror symmetry axis seen in the cosmic microwave background data from Planck probe is found.

  15. Rasagiline prevents cyclosporine A-sensitive superoxide flashes induced by PK11195, the initial signal of mitochondrial membrane permeabilization and apoptosis.

    Science.gov (United States)

    Wu, Yuqiu; Shamoto-Nagai, Masayo; Maruyama, Wakako; Osawa, Toshihiko; Naoi, Makoto

    2016-05-01

    Rasagiline, a neuroprotective inhibitor of type B monoamine oxidase, prevented PK111195-induced apoptosis in SH-SY5Y cells through inhibition of mitochondrial apoptosis signaling (J Neural Transm 120:1539-1551, 2013, J Neural Transm 122:1399-1407, 2015). This paper presents that PK11195 induced superoxide flashes, the transit production burst, mediated by cyclosporine A-sensitive membrane permeability transition. Rasagiline prevented superoxide flashes, calcium efflux, and cell death by PK11195. Regulation of the initial pore formation at the inner mitochondrial membrane was confirmed as the decisive mechanism of neuroprotection by rasagiline.

  16. Initiation but no execution - modulation of peripheral blood lymphocyte apoptosis in rheumatoid arthritis - a potential role for heat shock protein 70

    Directory of Open Access Journals (Sweden)

    Chuturgoon Anil A

    2011-11-01

    Full Text Available Abstract Background Rheumatoid arthritis (RA is a chronic autoimmune disease, which causes synovial damage. Persistence of lymphocyte infiltrates in the rheumatoid synovium has been attributed to abnormal apoptosis. While not comprehensively investigated, perturbations in peripheral blood lymphocyte (PBL apoptosis may also be involved in perpetuation of autoimmune processes in RA. Methods We investigated total, CD4+ and CD19+ PBL apoptosis in our study cohort by monitoring the translocation of phosphatidylserine using the Annexin-V assay. To examine the role of death receptor mediated apoptosis as well as activation-induced-cell-death (AICD, PBLs were labeled with CD95/Fas and CD69 markers and enumerated by flow cytometry. Proteolytic activity of initiator and executioner caspases was determined by luminometry. DNA fragmentation assays were used to examine whether apoptotic signals were transduced to the nucleus. Quantitative PCR arrays were used to investigate apoptotic pathways associated with RA-PBLs. Since heat-shock-protein-70 (HSP70 is an inducible protein which modulates apoptotic signals, we determined HSP70 levels by intra-cellular flow cytometry and western blots. Results The RA-PBLs showed signs of elevated apoptosis whilst in circulation. These include increases in the loss of plasma membrane asymmetry, indicated by increased externalization of phosphatidylserine (especially in B-lymphocytes. RA-PBLs showed a bias to CD95/Fas mediated apoptotic pathways, but low levels of the CD69 marker suggested that this was not associated with immune activation. Although downstream markers of apoptosis such as caspase-3/7 activity, were increased, no DNA fragmentation was observed in RA-PBLs. Interestingly, elevated levels of apoptosis did not correlate with absolute lymphocyte counts in RA patients. Levels of HSP70 were highly elevated in RA-PBLs compared to controls. Conclusion The results suggest that while apoptosis may be initiated in RA

  17. Common genomic signaling among initial DNA damage and radiation-induced apoptosis in peripheral blood lymphocytes from locally advanced breast cancer patients

    DEFF Research Database (Denmark)

    Henríquez-Hernández, Luis Alberto; Pinar, Beatriz; Carmona-Vigo, Ruth

    2013-01-01

    PURPOSE: To investigate the genomic signaling that defines sensitive lymphocytes to radiation and if such molecular profiles are consistent with clinical toxicity; trying to disclose the radiobiology mechanisms behind these cellular processes. PATIENTS AND METHODS: Twelve consecutive patients...... suffering from locally advanced breast cancer and treated with high-dose hyperfractionated radiotherapy were recruited. Initial DNA damage was measured by pulsed-field gel electrophoresis and radiation-induced apoptosis was measured by flow cytometry. Gene expression was assessed by DNA microarray. RESULTS...

  18. Highly Anisotropic Conductors.

    Science.gov (United States)

    Wan, Jiayu; Song, Jianwei; Yang, Zhi; Kirsch, Dylan; Jia, Chao; Xu, Rui; Dai, Jiaqi; Zhu, Mingwei; Xu, Lisha; Chen, Chaoji; Wang, Yanbin; Wang, Yilin; Hitz, Emily; Lacey, Steven D; Li, Yongfeng; Yang, Bao; Hu, Liangbing

    2017-11-01

    Composite materials with ordered microstructures often lead to enhanced functionalities that a single material can hardly achieve. Many biomaterials with unusual microstructures can be found in nature; among them, many possess anisotropic and even directional physical and chemical properties. With inspiration from nature, artificial composite materials can be rationally designed to achieve this anisotropic behavior with desired properties. Here, a metallic wood with metal continuously filling the wood vessels is developed, which demonstrates excellent anisotropic electrical, thermal, and mechanical properties. The well-aligned metal rods are confined and separated by the wood vessels, which deliver directional electron transport parallel to the alignment direction. Thus, the novel metallic wood composite boasts an extraordinary anisotropic electrical conductivity (σ || /σ ⊥ ) in the order of 10 11 , and anisotropic thermal conductivity (κ || /κ ⊥ ) of 18. These values exceed the highest reported values in existing anisotropic composite materials. The anisotropic functionality of the metallic wood enables it to be used for thermal management applications, such as thermal insulation and thermal dissipation. The highly anisotropic metallic wood serves as an example for further anisotropic materials design; other composite materials with different biotemplates/hosts and fillers can achieve even higher anisotropic ratios, allowing them to be implemented in a variety of applications. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  19. Caspase-10 Is the Key Initiator Caspase Involved in Tributyltin-Mediated Apoptosis in Human Immune Cells

    Directory of Open Access Journals (Sweden)

    Harald F. Krug

    2012-01-01

    Full Text Available Tributyltin (TBT is one of the most toxic compounds produced by man and distributed in the environment. A multitude of toxic activities have been described, for example, immunotoxic, neurotoxic, and endocrine disruptive effects. Moreover, it has been shown for many cell types that they undergo apoptosis after treatment with TBT and the cell death of immune cells could be the molecular background of its immunotoxic effect. As low as 200 nM up to 1 μM of TBT induces all signs of apoptosis in Jurkat T cells within 1 to 24 hrs of treatment. When compared to Fas-ligand control stimulation, the same sequence of events occurs: membrane blebbing, phosphatidylserine externalisation, the activation of the “death-inducing signalling complex,” and the following sequence of cleavage processes. In genetically modified caspase-8-deficient Jurkat cells, the apoptotic effects are only slightly reduced, whereas, in FADD-negative Jurkat cells, the TBT effect is significantly diminished. We could show that caspase-10 is recruited by the TRAIL-R2 receptor and apoptosis is totally prevented when caspase-10 is specifically inhibited in all three cell lines.

  20. Decreasing Eukaryotic Initiation Factor 3C (EIF3C) Suppresses Proliferation and Stimulates Apoptosis in Breast Cancer Cell Lines Through Mammalian Target of Rapamycin (mTOR) Pathway.

    Science.gov (United States)

    Zhao, Weipeng; Li, Xichuan; Wang, Jun; Wang, Chen; Jia, Yongsheng; Yuan, Shunzong; Huang, Yong; Shi, Yehui; Tong, Zhongsheng

    2017-08-30

    BACKGROUND Translation initiation is the rate limiting step of protein synthesis and is highly regulated. Eukaryotic initiation factor 3C (EIF3C), an oncogene overexpressed in several human cancers, plays an important role in tumorigenesis and cell proliferation. MATERIAL AND METHODS Immunohistochemistry was used to determine the expression of EIF3C in breast cancer tissues from 42 patients. We investigated whether EIF3C silencing decreases breast cancer cell proliferation as assessed by colony formation assay, and whether EIF3C gene knockdown induces apoptosis as assessed by flow cytometry analysis. We utilized the stress and apoptosis signaling antibody array kit, while p-ERK1/2, p-Akt, p-Smad2, p-p38 MAPK, cleaved caspase-3, and cleaved caspase-7 were explored between EIF3C-siRNA and controls. Furthermore, the effects of EIF3C gene knockdown in mTOR pathway were analyzed by western blotting for different cell lines. RESULTS In EIF3C-positive tumors, 32 out of 42 showed significantly higher frequencies of high grade group by immunoreactivity (p=0.0016). BrdU incorporation after four days of cell plating was significantly suppressed in MDA-MB-231 cells by EIF3C knockdown compared with controls, with average changes of 7.8-fold (pcells by EIF3C knockdown compared with controls (pCell apoptosis was significantly increased in the EIF3C-siRNA group when compared with the cells that were transfected with scrambled siRNA (3.51±0.0842 versus 13.24±0.2307, p<0.01). The mTOR signaling pathway was involved in decreasing EIF3C translational efficiency. CONCLUSIONS Unveiling the mechanisms of EIF3 action in tumorigenesis may help identify attractive targets for cancer therapy.

  1. Lysosomal cathepsin initiates apoptosis, which is regulated by photodamage to Bcl-2 at mitochondria in photodynamic therapy using a novel photosensitizer, ATX-s10 (Na).

    Science.gov (United States)

    Ichinose, Shuji; Usuda, Jitsuo; Hirata, Takeshi; Inoue, Tatsuya; Ohtani, Keishi; Maehara, Sachio; Kubota, Mitsuhiro; Imai, Kentarou; Tsunoda, Yoshihiko; Kuroiwa, Yukari; Yamada, Kimito; Tsutsui, Hidemitsu; Furukawa, Kinya; Okunaka, Tetsuya; Oleinick, Nancy L; Kato, Harubumi

    2006-08-01

    ATX-s10 is a novel and second-generation photosensitizer for photodynamic therapy (PDT). In order to conduct clinical trials of ATX-s10-PDT and/or extend its clinical applications, it is very important to elucidate the mechanisms of the action of ATX-s10-PDT. We examined the apoptic response against ATX-s10-PDT using a Bcl-2 or Bcl-2 mutant overexpressing cells. Using fluorescent microscopy, ATX-s10 localized not only to mitochondria but also to lysosomes and possibly other intracellular organelles, but not to the plasma membrane or the nucleus. These results suggest that ATX-s10-PDT can damage mitochondria and lysosomes. By Western blot analysis, ATX-s10-PDT damaged Bcl-2, which localized preferentially at mitochondrial membranes, and caused Bcl-2 to cross-link immediately after laser irradiation. However, ATX-s10-PDT was not able to rapidly induce morphologically typical apoptosis (i.e. chromatin condensation and fragmentation) as PDT using mitochondria targeted photosensitizers, such as phthalocyanine 4 (Pc 4). Pharmacological inhibitions of lysosomal cytokine protease cathepsins, such as cathepsin B and D, protected MCF-7c3 cells (human breast cancer cells expressing stably transfected procaspase-3) from apoptosis caused by ATX-s10-PDT. Overexpression of wild-type Bcl-2 or Bcl-2Delta33-54 resulted in relative resistance of cells to ATX-s10-PDT, as assessed by the degree of morphological apoptosis or loss of clonogenicity. We conclude that lysosomal damage by ATX-s10-PDT can initiate apoptotic response and this apoptotic pathway can be regulated by photodamage to Bcl-2 via mitochondrial damage.

  2. Anisotropic light diffusion: an oxymoron?

    Science.gov (United States)

    Kienle, Alwin

    2007-05-25

    Light propagation in anisotropic random media is studied in the steady-state and time domains. Solutions of the anisotropic diffusion equation are compared to results obtained by the Monte Carlo method. Contrary to what has been reported so far, we find that even in the "diffusive regime" the anisotropic diffusion equation does not describe correctly the light propagation in anisotropic random media.

  3. Wave velocities in a pre-stressed anisotropic elastic medium

    Indian Academy of Sciences (India)

    Wave velocities in a pre-stressed anisotropic elastic medium. M D Sharma ... Modified Christoffel equations are derived for three-dimensional wave propagation in a general anisotropic medium under initial stress.The three roots of a ... Department of Mathematics, Kurukshetra University, Kurukshetra 136 119, India. UIET ...

  4. Anisotropic Flow Measurements in ALICE at the Large Hadron Collider

    NARCIS (Netherlands)

    Bilandzic, A.

    2012-01-01

    Anisotropic flow is one of the observables which is sensitive to the properties of the created hot and dense system in heavy-ion collisions. In noncentral heavy-ion collisions the initial volume of the interacting system is anisotropic in coordinate space. Due to multiple interactions this anisotropy

  5. Correlation of the microculture-kinetic drug-induced apoptosis assay with patient outcomes in initial treatment of adult acute myelocytic leukemia.

    Science.gov (United States)

    Strickland, Stephen A; Raptis, Anastasios; Hallquist, Allan; Rutledge, James; Chernick, Michael; Perree, Mathieu; Talbott, Mahsa S; Presant, Cary A

    2013-03-01

    Overall survival (OS) with acute myeloid leukemia (AML) remains poor. Determining prognostic factors will help in selecting patients for appropriate treatments. Our aim was to determine whether the level of drug-induced apoptosis (chemosensitivity) demonstrated by the microculture-kinetic drug-induced apoptosis (MiCK) assay significantly predicted outcomes after standard AML induction therapy. A total of 109 patients with untreated AML had blood and/or bone marrow aspirate samples analyzed for anthracycline-induced apoptosis using the MiCK assay. The amount of apoptosis observed over 48 h was determined and expressed as kinetic units of apoptosis (KU). Complete remission (CR) was significantly higher (72%) in patients with high idarubicin-induced apoptosis >3 KU compared to patients with apoptosis ≤ 3 KU (p = 0.01). Multivariate analysis showed the only significant variables to be idarubicin-induced apoptosis and karyotype. Median overall survival of patients with idarubicin-induced apoptosis >3 KU was 16.1 months compared to 4.5 months in patients with apoptosis ≤ 3 KU (p = 0.004). Multivariate analysis showed the only significant variable to be idarubicin-induced apoptosis. Chemotherapy-induced apoptosis measured by the MiCK assay demonstrated significant correlation with outcomes and appears predictive of complete remission and overall survival for patients receiving standard induction chemotherapy.

  6. Anisotropic ray trace

    Science.gov (United States)

    Lam, Wai Sze Tiffany

    Optical components made of anisotropic materials, such as crystal polarizers and crystal waveplates, are widely used in many complex optical system, such as display systems, microlithography, biomedical imaging and many other optical systems, and induce more complex aberrations than optical components made of isotropic materials. The goal of this dissertation is to accurately simulate the performance of optical systems with anisotropic materials using polarization ray trace. This work extends the polarization ray tracing calculus to incorporate ray tracing through anisotropic materials, including uniaxial, biaxial and optically active materials. The 3D polarization ray tracing calculus is an invaluable tool for analyzing polarization properties of an optical system. The 3x3 polarization ray tracing P matrix developed for anisotropic ray trace assists tracking the 3D polarization transformations along a ray path with series of surfaces in an optical system. To better represent the anisotropic light-matter interactions, the definition of the P matrix is generalized to incorporate not only the polarization change at a refraction/reflection interface, but also the induced optical phase accumulation as light propagates through the anisotropic medium. This enables realistic modeling of crystalline polarization elements, such as crystal waveplates and crystal polarizers. The wavefront and polarization aberrations of these anisotropic components are more complex than those of isotropic optical components and can be evaluated from the resultant P matrix for each eigen-wavefront as well as for the overall image. One incident ray refracting or reflecting into an anisotropic medium produces two eigenpolarizations or eigenmodes propagating in different directions. The associated ray parameters of these modes necessary for the anisotropic ray trace are described in Chapter 2. The algorithms to calculate the P matrix from these ray parameters are described in Chapter 3 for

  7. Apoptosis signaling and radiation protection

    International Nuclear Information System (INIS)

    Morita, Akinori; Suzuki, Norio; Hosoi, Yoshio

    2005-01-01

    Radiation protection by apoptosis control is the suppression of cell death in highly radiosensitive tissues. This paper describes the outline of radiation-induced apoptosis framework, apoptosis-concerned target molecules possibly related to apoptosis by radiation and their inhibitors. Although there are intrinsic (via mitochondria) and extrinsic (via death receptor) pathways in apoptosis, this review mainly mentions the former which is more important in radiation-induced apoptosis. Those molecules known at present in the apoptosis are caspase, Bcl-2 family and p53. Caspase, a group of cystein proteases, initiates apoptosis but its inhibition is known not always to result in apoptosis suppression, suggesting the existence of caspase-independent pathways. Bcl-2 family involves apoptosis-suppressing (possessing BH domains) and -promoting (lacking BH domains or possessing BH3 domain alone/BH3-only protein) groups. Two p53-transcription-dependent and one -independent pathways in p53-induced apoptosis are known and p53 can be a most possible target molecule since it positions at the start of apoptosis. Authors have found a vanadate inactivates p53. Inhibitors affecting upstream molecules of apoptosis will be the most useful candidate for apoptosis suppression/radiation protection. (S.I.) 106 refs

  8. Esculetin, a coumarin derivative, exerts in vitro and in vivo antiproliferative activity against hepatocellular carcinoma by initiating a mitochondrial-dependent apoptosis pathway

    Directory of Open Access Journals (Sweden)

    J. Wang

    2015-03-01

    Full Text Available This study investigated the in vitro and in vivo antiproliferative activity of esculetin against hepatocellular carcinoma, and clarified its potential molecular mechanisms. Cell viability was determined by the MTT (tetrazolium colorimetric assay. In vivo antitumor activity of esculetin was evaluated in a hepatocellular carcinoma mouse model. Seventy-five C57BL/6J mice were implanted with Hepa1-6 cells and randomized into five groups (n=15 each given daily intraperitoneal injections of vehicle (physiological saline, esculetin (200, 400, or 700 mg·kg-1·day-1, or 5-Fu (200 mg·kg-1·day-1 for 15 days. Esculetin significantly decreased tumor growth in mice bearing Hepa1-6 cells. Tumor weight was decreased by 20.33, 40.37, and 55.42% with increasing doses of esculetin. Esculetin significantly inhibited proliferation of HCC cells in a concentration- and time-dependent manner and with an IC50 value of 2.24 mM. It blocked the cell cycle at S phase and induced apoptosis in SMMC-7721 cells with significant elevation of caspase-3 and caspase-9 activity, but did not affect caspase-8 activity. Moreover, esculetin treatment resulted in the collapse of mitochondrial membrane potential in vitro and in vivo accompanied by increased Bax expression and decreased Bcl-2 expression at both transcriptional and translational levels. Thus, esculetin exerted in vitro and in vivo antiproliferative activity in hepatocellular carcinoma, and its mechanisms involved initiation of a mitochondrial-mediated, caspase-dependent apoptosis pathway.

  9. Anisotropic responses and initial decomposition of condensed-phase β-HMX under shock loadings via molecular dynamics simulations in conjunction with multiscale shock technique.

    Science.gov (United States)

    Ge, Ni-Na; Wei, Yong-Kai; Song, Zhen-Fei; Chen, Xiang-Rong; Ji, Guang-Fu; Zhao, Feng; Wei, Dong-Qing

    2014-07-24

    Molecular dynamics simulations in conjunction with multiscale shock technique (MSST) are performed to study the initial chemical processes and the anisotropy of shock sensitivity of the condensed-phase HMX under shock loadings applied along the a, b, and c lattice vectors. A self-consistent charge density-functional tight-binding (SCC-DFTB) method was employed. Our results show that there is a difference between lattice vector a (or c) and lattice vector b in the response to a shock wave velocity of 11 km/s, which is investigated through reaction temperature and relative sliding rate between adjacent slipping planes. The response along lattice vectors a and c are similar to each other, whose reaction temperature is up to 7000 K, but quite different along lattice vector b, whose reaction temperature is only up to 4000 K. When compared with shock wave propagation along the lattice vectors a (18 Å/ps) and c (21 Å/ps), the relative sliding rate between adjacent slipping planes along lattice vector b is only 0.2 Å/ps. Thus, the small relative sliding rate between adjacent slipping planes results in the temperature and energy under shock loading increasing at a slower rate, which is the main reason leading to less sensitivity under shock wave compression along lattice vector b. In addition, the C-H bond dissociation is the primary pathway for HMX decomposition in early stages under high shock loading from various directions. Compared with the observation for shock velocities V(imp) = 10 and 11 km/s, the homolytic cleavage of N-NO2 bond was obviously suppressed with increasing pressure.

  10. Anisotropic contrast optical microscope.

    Science.gov (United States)

    Peev, D; Hofmann, T; Kananizadeh, N; Beeram, S; Rodriguez, E; Wimer, S; Rodenhausen, K B; Herzinger, C M; Kasputis, T; Pfaunmiller, E; Nguyen, A; Korlacki, R; Pannier, A; Li, Y; Schubert, E; Hage, D; Schubert, M

    2016-11-01

    An optical microscope is described that reveals contrast in the Mueller matrix images of a thin, transparent, or semi-transparent specimen located within an anisotropic object plane (anisotropic filter). The specimen changes the anisotropy of the filter and thereby produces contrast within the Mueller matrix images. Here we use an anisotropic filter composed of a semi-transparent, nanostructured thin film with sub-wavelength thickness placed within the object plane. The sample is illuminated as in common optical microscopy but the light is modulated in its polarization using combinations of linear polarizers and phase plate (compensator) to control and analyze the state of polarization. Direct generalized ellipsometry data analysis approaches permit extraction of fundamental Mueller matrix object plane images dispensing with the need of Fourier expansion methods. Generalized ellipsometry model approaches are used for quantitative image analyses. These images are obtained from sets of multiple images obtained under various polarizer, analyzer, and compensator settings. Up to 16 independent Mueller matrix images can be obtained, while our current setup is limited to 11 images normalized by the unpolarized intensity. We demonstrate the anisotropic contrast optical microscope by measuring lithographically defined micro-patterned anisotropic filters, and we quantify the adsorption of an organic self-assembled monolayer film onto the anisotropic filter. Comparison with an isotropic glass slide demonstrates the image enhancement obtained by our method over microscopy without the use of an anisotropic filter. In our current instrument, we estimate the limit of detection for organic volumetric mass within the object plane of ≈49 fg within ≈7 × 7 μm 2 object surface area. Compared to a quartz crystal microbalance with dissipation instrumentation, where contemporary limits require a total load of ≈500 pg for detection, the instrumentation demonstrated here improves

  11. Anisotropic Weyl invariance

    Energy Technology Data Exchange (ETDEWEB)

    Perez-Nadal, Guillem [Universidad de Buenos Aires, Buenos Aires (Argentina)

    2017-07-15

    We consider a non-relativistic free scalar field theory with a type of anisotropic scale invariance in which the number of coordinates ''scaling like time'' is generically greater than one. We propose the Cartesian product of two curved spaces, the metric of each space being parameterized by the other space, as a notion of curved background to which the theory can be extended. We study this type of geometries, and find a family of extensions of the theory to curved backgrounds in which the anisotropic scale invariance is promoted to a local, Weyl-type symmetry. (orig.)

  12. Anisotropic Lyra cosmology

    Indian Academy of Sciences (India)

    Anisotropic Bianchi Type-I cosmological models have been studied on the basis of Lyra's geometry. Two types of models, one with constant deceleration parameter and the other with variable deceleration parameter have been derived by considering a time-dependent displacement field.

  13. Anisotropic Concrete Compressive Strength

    DEFF Research Database (Denmark)

    Gustenhoff Hansen, Søren; Jørgensen, Henrik Brøner; Hoang, Linh Cao

    2017-01-01

    When the load carrying capacity of existing concrete structures is (re-)assessed it is often based on compressive strength of cores drilled out from the structure. Existing studies show that the core compressive strength is anisotropic; i.e. it depends on whether the cores are drilled parallel...

  14. Cryptotanshinone induces cell cycle arrest and apoptosis of multidrug resistant human chronic myeloid leukemia cells by inhibiting the activity of eukaryotic initiation factor 4E.

    Science.gov (United States)

    Ge, Yuqing; Cheng, Rubin; Zhou, Yuhong; Shen, Jianping; Peng, Laijun; Xu, Xiaofeng; Dai, Qun; Liu, Pei; Wang, Haibing; Ma, Xiaoqiong; Jia, Jia; Chen, Zhe

    2012-09-01

    Cryptotanshinone (CPT), a diterpene quinone isolated from Salvia miltiorrhiza, is recently reported to have obvious anticancer activities against diverse cancer cells. However, the effect and regulatory mechanism of CPT remain unclear in human chronic myeloid leukemia (CML) cells. In this study, we investigated the antiproliferative activity of CPT on the multidrug resistant CML cells K562/ADM. Our results demonstrated that CPT decreased the cell viability of K562/ADM cells by inducing cell cycle arrest and apoptosis through suppressing the expression of cyclin D1 and Bcl-2. Further studies indicated that CPT mainly functions at post-transcriptional levels, suggesting the involvement of eukaryotic initiation factor 4E (eIF4E). CPT significantly reduced the expression and activity of eIF4E in K562/ADM cells. Overexpression of eIF4E obvious conferred resistance to the CPT antiproliferation and proapoptotic activity as well as the cyclin D1 and Bcl-2 expressions. Knockdown of eIF4E significantly reduced the inhibitory effect of CPT in K562/ADM, confirming the participation of eIF4E during CPT function process. More importantly, the relative inhibitory efficiency of CPT positively correlated with the reductions on eIF4E in primary CML specimens. These results demonstrated that CPT played antitumor roles in K562/ADM cells by inhibiting the eIF4E regulatory system. Our results provide a novel anticancer mechanism of CPT in human CML cells.

  15. Longitudinal fluctuations and decorrelation of anisotropic flow

    Energy Technology Data Exchange (ETDEWEB)

    Pang, Long-Gang [Frankfurt Institute for Advanced Studies, Ruth-Moufang-Strasse 1, 60438 Frankfurt am Main (Germany); Petersen, Hannah [Frankfurt Institute for Advanced Studies, Ruth-Moufang-Strasse 1, 60438 Frankfurt am Main (Germany); Institute for Theoretical Physics, Goethe University, Max-von-Laue-Strasse 1, 60438 Frankfurt am Main (Germany); GSI Helmholtzzentrum für Schwerionenforschung, Planckstr. 1, 64291 Darmstadt (Germany); Qin, Guang-You [Key Laboratory of Quark & Lepton Physics (MOE) and Institute of Particle Physics, Central China Normal University, Wuhan 430079 (China); Roy, Victor [Institute for Theoretical Physics, Goethe University, Max-von-Laue-Strasse 1, 60438 Frankfurt am Main (Germany); Wang, Xin-Nian [Key Laboratory of Quark & Lepton Physics (MOE) and Institute of Particle Physics, Central China Normal University, Wuhan 430079 (China); Nuclear Science Division MS70R0319, Lawrence Berkeley National Laboratory, Berkeley, CA 94720 (United States)

    2016-12-15

    We investigate the decorrelation of 2nd and 3rd order anisotropic flow for charged particles in two different pseudo rapidity (η) windows by varying the pseudo rapidity gap, in an event-by-event (3+1)D ideal hydrodynamic model, with fluctuating initial conditions from A Multi-Phase Transport (AMPT) model. We visualize the parton distribution at initial state for Pb+Pb collisions at LHC and Au+Au collisions at RHIC, and demonstrate the longitudinal fluctuations originating from the asymmetry between forward and backward going participants, the fluctuations of the string length and the fluctuations due to finite number of partons at different beam energies. The decorrelation of anisotropic flow of final hadrons with large η gaps is found to originate from the spatial decorrelation along the longitudinal direction in the AMPT initial conditions through hydrodynamic evolution. The agreement between our results and recent CMS data in most centralities suggests that the string-like mechanism of initial parton production in AMPT model captures the initial longitudinal fluctuation that is responsible for the measured decorrelation of anisotropic flow in Pb+Pb collisions at LHC. Our predictions for Au+Au collisions at the highest RHIC energy show stronger longitudinal decorrelation than at LHC, indicating larger longitudinal fluctuations at lower beam energies.

  16. Response of thyroid follicular cells to gamma irradiation compared to proton irradiation. I. Initial characterization of DNA damage, micronucleus formation, apoptosis, cell survival, and cell cycle phase redistribution

    Science.gov (United States)

    Green, L. M.; Murray, D. K.; Bant, A. M.; Kazarians, G.; Moyers, M. F.; Nelson, G. A.; Tran, D. T.

    2001-01-01

    The RBE of protons has been assumed to be equivalent to that of photons. The objective of this study was to determine whether radiation-induced DNA and chromosome damage, apoptosis, cell killing and cell cycling in organized epithelial cells was influenced by radiation quality. Thyroid-stimulating hormone-dependent Fischer rat thyroid cells, established as follicles, were exposed to gamma rays or proton beams delivered acutely over a range of physical doses. Gamma-irradiated cells were able to repair DNA damage relatively rapidly so that by 1 h postirradiation they had approximately 20% fewer exposed 3' ends than their counterparts that had been irradiated with proton beams. The persistence of free ends of DNA in the samples irradiated with the proton beam implies that either more initial breaks or a quantitatively different type of damage had occurred. These results were further supported by an increased frequency of chromosomal damage as measured by the presence of micronuclei. Proton-beam irradiation induced micronuclei at a rate of 2.4% per gray, which at 12 Gy translated to 40% more micronuclei than in comparable gamma-irradiated cultures. The higher rate of micronucleus formation and the presence of larger micronuclei in proton-irradiated cells was further evidence that a qualitatively more severe class of damage had been induced than was induced by gamma rays. Differences in the type of damage produced were detected in the apoptosis assay, wherein a significant lag in the induction of apoptosis occurred after gamma irradiation that did not occur with protons. The more immediate expression of apoptotic cells in the cultures irradiated with the proton beam suggests that the damage inflicted was more severe. Alternatively, the cell cycle checkpoint mechanisms required for recovery from such damage might not have been invoked. Differences based on radiation quality were also evident in the alpha components of cell survival curves (0.05 Gy(-1) for gamma rays, 0

  17. Caspases: An apoptosis mediator

    Directory of Open Access Journals (Sweden)

    Tapan Kumar Palai

    2015-03-01

    Full Text Available The process of programmed cell death, or apoptosis, is generally characterized by distinct morphological characteristics and energy - dependent biochemical mechanisms. Apoptosis is a widely conserved phenomenon helping many processes, including normal cell turnover, proper development and functioning of the immune system, hormone dependent atrophy etc. Inappropriate apoptosis (either low level or high level leads to many developmental abnormalities like, neurodegenerative diseases, ischemic damage, autoimmune disorders and many types of cancer. To use cells for therapeutic purposes through generating cell lines, it is critical to study the cell cycle machinery and signalling pathways that controls cell death and apoptosis. Apoptotic pathways provide a fundamental protective mechanism that decreases cellular sensitivity to damaging events and allow proper developmental process in multi-cellular organisms. Major mediator of apoptosis is a family of proteins known as caspases. There are mainly fourteen types of caspases but out of them only ten caspasese have got essential role in controlling the process of apoptosis. These ten caspases have been categorized into either initiator caspases (caspase 2, 8, 9, 10 or executioner caspases (caspase 3, 6, 7. Although various types of caspases have been identified so far, the exact mechanisms of action of these groups of proteins is still to be fully understood. The aim of this review is to provide a detail overview of role of different caspases in regulating the process of apoptosis.

  18. Anisotropic elliptic optical fibers

    Science.gov (United States)

    Kang, Soon Ahm

    1991-05-01

    The exact characteristic equation for an anisotropic elliptic optical fiber is obtained for odd and even hybrid modes in terms of infinite determinants utilizing Mathieu and modified Mathieu functions. A simplified characteristic equation is obtained by applying the weakly guiding approximation such that the difference in the refractive indices of the core and the cladding is small. The simplified characteristic equation is used to compute the normalized guide wavelength for an elliptical fiber. When the anisotropic parameter is equal to unity, the results are compared with the previous research and they are in close agreement. For a fixed value normalized cross-section area or major axis, the normalized guide wavelength lambda/lambda(sub 0) for an anisotropic elliptic fiber is small for the larger value of anisotropy. This condition indicates that more energy is carried inside of the fiber. However, the geometry and anisotropy of the fiber have a smaller effect when the normalized cross-section area is very small or very large.

  19. Dynamics of anisotropic particles under waves

    Science.gov (United States)

    Dibenedetto, Michelle; Ouellette, Nicholas; Koseff, Jeffrey

    2017-11-01

    We present results on anisotropic particles in wavy flows in order to gain insight into the transport and mixing of microplastic particles in the near-shore environment. From theory and numerical simulations, we find that the rate of alignment of the particles is not constant and depends strongly on their initial orientation; thus, variations in initial particle orientation result in dispersion of anisotropic-particle plumes. We find that this dispersion is a function of the particle's eccentricity and the ratio of the settling and wave time scales. Experiments in which non-spherical particles of various shapes are released under surface gravity waves were also performed. Our main goal is to explore the effects of particle shape under various wave scenarios. We vary the aspect ratio of the particle in our experiments while holding other variables constant. Our results demonstrate that particle shape can be important when predicting transport.

  20. Anisotropic wave-equation traveltime and waveform inversion

    KAUST Repository

    Feng, Shihang

    2016-09-06

    The wave-equation traveltime and waveform inversion (WTW) methodology is developed to invert for anisotropic parameters in a vertical transverse isotropic (VTI) meidum. The simultaneous inversion of anisotropic parameters v0, ε and δ is initially performed using the wave-equation traveltime inversion (WT) method. The WT tomograms are then used as starting background models for VTI full waveform inversion. Preliminary numerical tests on synthetic data demonstrate the feasibility of this method for multi-parameter inversion.

  1. An anisotropic tertiary creep damage constitutive model for anisotropic materials

    International Nuclear Information System (INIS)

    Stewart, Calvin M.; Gordon, Ali P.; Ma, Young Wha; Neu, Richard W.

    2011-01-01

    When an anisotropic material is subject to creep conditions and a complex state of stress, an anisotropic creep damage behavior is observed. Previous research has focused on the anisotropic creep damage behavior of isotropic materials but few constitutive models have been developed for anisotropic creeping solids. This paper describes the development of a new anisotropic tertiary creep damage constitutive model for anisotropic materials. An advanced tensorial damage formulation is implemented which includes both material orientation relative to loading and the degree of creep damage anisotropy in the model. A variation of the Norton-power law for secondary creep is implemented which includes the Hill's anisotropic analogy. Experiments are conducted on the directionally-solidified bucket material DS GTD-111. The constitutive model is implemented in a user programmable feature (UPF) in ANSYS FEA software. The ability of the constitutive model to regress to the Kachanov-Rabotnov isotropic tertiary creep damage model is demonstrated through comparison with uniaxial experiments. A parametric study of both material orientation and stress rotation are conducted. Results indicate that creep deformation is modeled accurately; however an improved damage evolution law may be necessary. - Highlights: → The deformation of anisotropic creeping solid is directionally dependent. → Few constitutive models have been developed to deal with anisotropic behavior. → A transversely-isotropic nickel base superalloy, DS GTD-111, is studied. → A vector constitutive model based on the Kachanov-Rabotnov formulation is developed. → The new model accurately models deformation at various orientations.

  2. A unified theoretical and experimental study of anisotropic hardening

    International Nuclear Information System (INIS)

    Boehler, J.P.; Raclin, J.

    1981-01-01

    The purpose of this work is to develop a consistent formulation of the constitutive relations regarding anisotropic hardening materials. Attention is focused on the appearance and the evolution of mechanical anisotropies during irreversible processes, such as plastic forming and inelastic deformation of structures. The representation theorems for anisotropic tensor functions constitute a theoretical basis, allowing to reduce arbitrariness and to obtain a unified formulation of anisotropic hardening. In this approach, a general three-dimensional constitutive law is developed for prestrained initially orthotropic materials. Introduction of the plastic behavior results in the general forms of both the flow-law and the yield criterion. The developed theory is then specialized for the case of plane stress and different modes of anisotropic hardening are analyzed. A new generalization of the Von Mises criterion is proposed, in considering a homogeneous form of order two in stress and employing the simplest combinations of the basic invariants entering the general form of the yield condition. The proposed criterion involves specific terms accounting for the initial anisotropy, the deformation induced anisotropy and correlative terms between initial and induced anisotropy. The effects of prestrainings result in both isotropic and anisotropic hardening. An adequate experimental program, consisting of uniaxial tensile tests on oriented specimens of prestrained sheet-metal, was performed, in order to determine the specific form and the evolution of the anisotropic failure criterion for soft-steel subjected to different irreversible prestrainings. (orig.)

  3. Material Induced Anisotropic Damage in DP600

    NARCIS (Netherlands)

    Niazi, Muhammad Sohail; Wisselink, H.H.; Meinders, Vincent T.; van den Boogaard, Antonius H.

    2013-01-01

    Plasticity induced damage development in metals is anisotropic by nature. The anisotropy in damage is driven by two different phenomena; anisotropic deformation state i.e. Load Induced Anisotropic Damage (LIAD) and anisotropic microstructure i.e. Material Induced Anisotropic Damage (MIAD). The

  4. Anisotropic power-law k-inflation

    Science.gov (United States)

    Ohashi, Junko; Soda, Jiro; Tsujikawa, Shinji

    2013-11-01

    It is known that power-law k-inflation can be realized for the Lagrangian P=Xg(Y), where X=-(∂ϕ)2/2 is the kinetic energy of a scalar field ϕ and g is an arbitrary function in terms of Y=Xeλϕ/Mpl (λ is a constant and Mpl is the reduced Planck mass). In the presence of a vector field coupled to the inflaton with an exponential coupling f(ϕ)∝eμϕ/Mpl, we show that the models with the Lagrangian P=Xg(Y) generally give rise to anisotropic inflationary solutions with Σ/H=constant, where Σ is an anisotropic shear and H is an isotropic expansion rate. Provided these anisotropic solutions exist in the regime where the ratio Σ/H is much smaller than 1, they are stable attractors irrespective of the forms of g(Y). We apply our results to concrete models of k-inflation such as the generalized dilatonic ghost condensate and the Dirac-Born-Infeld model and we numerically show that the solutions with different initial conditions converge to the anisotropic power-law inflationary attractors. Even in the de Sitter limit (λ→0) such solutions can exist, but in this case the null energy condition is generally violated. The latter property is consistent with the Wald’s cosmic conjecture stating that the anisotropic hair does not survive on the de Sitter background in the presence of matter respecting the dominant/strong energy conditions.

  5. Glucocorticoid-Mediated Repression of the Oncogenic microRNA Cluster miR-17∼92 Contributes to the Induction of Bim and Initiation of Apoptosis

    Science.gov (United States)

    Molitoris, Jason K.; McColl, Karen S.

    2011-01-01

    Synthetic glucocorticoids were one of the first effective treatments for lymphoid malignancies because of their ability to induce apoptosis and are still used in combination with other chemotherapeutic agents. Up-regulation of Bim, a proapoptotic member of the B-cell lymphoma-2 family, is an important mediator of glucocorticoid-induced apoptosis. Although glucocorticoids are known to elevate Bim mRNA and protein, little is known about the mechanism. Here, we report that glucocorticoids repress the expression of the microRNA cluster miR-17∼92, which results in elevated Bim protein expression as a mechanism by which glucocorticoids induce Bim. Using a luciferase-Bim 3′ untranslated region construct, we demonstrate that glucocorticoids mediate Bim induction posttranscriptionally after miR-17∼92 repression, resulting in increased Bim protein expression. Overexpression of miR-17∼92 microRNAs decreases Bim induction and attenuates glucocorticoid-mediated apoptosis. Conversely, knockdown of miR-17∼92 increases Bim protein expression and glucocorticoid-mediated apoptosis. These findings indicate that endogenous levels of miR-17∼92 repress Bim expression in T-cell lymphoid malignancies and that glucocorticoids induce Bim expression via down-regulation of the miR-17∼92 microRNA cluster. Our findings present a novel mechanism that contributes to the up-regulation of Bim and induction of apoptosis in lymphocytes after glucocorticoid treatment. Furthermore, our work demonstrating that inhibition of miR-17∼92 increases glucocorticoid-induced apoptosis highlights the potential importance of miR-17∼92 as a therapeutic target in leukemias and lymphomas. PMID:21239610

  6. Anisotropic Concrete Compressive Strength

    DEFF Research Database (Denmark)

    Gustenhoff Hansen, Søren; Jørgensen, Henrik Brøner; Hoang, Linh Cao

    2017-01-01

    When the load carrying capacity of existing concrete structures is (re-)assessed it is often based on compressive strength of cores drilled out from the structure. Existing studies show that the core compressive strength is anisotropic; i.e. it depends on whether the cores are drilled parallel...... correlation to the curing time. The experiments show no correlation between the anisotropy and the curing time and a small strength difference between the two drilling directions. The literature shows variations on which drilling direction that is strongest. Based on a Monto Carlo simulation of the expected...

  7. The significance of intestinal apoptosis

    International Nuclear Information System (INIS)

    Potten, C.S.

    1997-01-01

    Apoptosis occurs at a low level spontaneously in the small intestine (SI). The levels can be raised by a variety of cytotoxic agents including radiation. The apoptosis induced by radiation, and some drugs and the spontaneous apoptosis, show some specificity for the stem cells in the small intestinal crypt. In the colon, these agents target transit cells in the mid crypt. p53 expression is elevated at the same time as apoptosis in the SI but not in the cells undergoing apoptosis. The expression of bcl-2, a survival gene, is largely absent in the SI, but is expressed, albeit weakly, in the stem cells in the colon. Spontaneous apoptosis is observed in p53 null mice which also develop normally suggesting that spontaneous and developmental apoptosis are p53 independent and that spontaneous apoptosis is part of the homeostatic mechanisms maintaining stem cell numbers. Radiation induced apoptosis is completely absent at these early times post-irradiation in p53 nulls. In bel-2 null mice, the levels of spontaneous and radiation induced apoptosis are elevated in the colon. Bax, a death gene, is expressed on the villus and inter-crypt table in the colon suggesting that cells at the end of their lifespan initiate apoptosis. It has been suggested that apoptosis in the SI is a protective mechanism against carcinogenesis in the stem cells of the SI which rarely develops cancer. Cells that possess genetic damage detected. In the large bowel, this mechanism is not effective due to the action of bcl-2. Thus stem cells may persist in this tissue with genetic damage resulting in a higher cancer risk. Furthermore, the lack of spontaneous apoptosis in the colon may result in a gradual increase of the stem cells with time resulting in more ells at risk. (author)

  8. Transient anisotropic magnetic field calculation

    International Nuclear Information System (INIS)

    Jesenik, Marko; Gorican, Viktor; Trlep, Mladen; Hamler, Anton; Stumberger, Bojan

    2006-01-01

    For anisotropic magnetic material, nonlinear magnetic characteristics of the material are described with magnetization curves for different magnetization directions. The paper presents transient finite element calculation of the magnetic field in the anisotropic magnetic material based on the measured magnetization curves for different magnetization directions. For the verification of the calculation method some results of the calculation are compared with the measurement

  9. Cl- channels in apoptosis

    DEFF Research Database (Denmark)

    Wanitchakool, Podchanart; Ousingsawat, Jiraporn; Sirianant, Lalida

    2016-01-01

    A remarkable feature of apoptosis is the initial massive cell shrinkage, which requires opening of ion channels to allow release of K(+), Cl(-), and organic osmolytes to drive osmotic water movement and cell shrinkage. This article focuses on the role of the Cl(-) channels LRRC8, TMEM16/anoctamin......, and cystic fibrosis transmembrane conductance regulator (CFTR) in cellular apoptosis. LRRC8A-E has been identified as a volume-regulated anion channel expressed in many cell types. It was shown to be required for regulatory and apoptotic volume decrease (RVD, AVD) in cultured cell lines. Its presence also...

  10. Physician Education: Apoptosis.

    Science.gov (United States)

    Kataoka; Tsuruo

    1996-01-01

    We have come to understand apoptosis as not merely a single form of cell death, but as a fundamental theme in cell biology that has far-reaching implications in the fields of physiology and pathology. At the present time, however, the mechanism of apoptosis is not clearly understood, as research into apoptosis is still at the initial stages. Nevertheless, the links between apoptosis and a variety of pathological conditions are gradually becoming clearer. In this article, we will provide a simple explanation of apoptosis and its mechanism as a novel concept of cell death and discuss the way in which apoptosis has been linked to a variety of pathological conditions. WHAT IS APOPTOSIS?: In normal tissue, cells that are no longer needed are rapidly eliminated without affecting the overall function of the tissue. In this process cells undergo an active and spontaneous suicide called programmed cell death. In fact, the majority of physiological cell deaths take the form of apoptosis. The word apoptosis is used, in contrast to necrosis, to describe the situation in which a cell actively pursues a course toward death upon receiving certain stimuli [1]. The morphological changes of apoptosis found in most cell types first involve contraction in cell volume and condensation of the nucleus. When this happens the intracellular organelles such as the mitochondria retain their normal morphology. As apoptosis proceeds, blebbing of the plasma membrane occurs, and the nucleus becomes fragmented. Finally, the cell itself fragments to form apoptotic bodies that are engulfed by nearby phagocytes. With respect to biochemical changes, it is known that the chromosomes become fragmented into nucleosome units, and DNA forms characteristic ladder patterns when subjected to agarose gel electrophoresis. MECHANISM OF APOPTOSIS: It has been reported that apoptosis is induced in various cells by many kinds of irritations, but the precise mechanism is still unclear. Cell injuries that induce

  11. Propagation of S-waves in a non-homogeneous anisotropic ...

    African Journals Online (AJOL)

    homogeneous anisotropic incompressible and initially stressed medium. Analytical analysis reveals that the velocities of the shear waves depend upon the direction of propagation, the anisotropy, the non-homogeneity of the medium and the initial ...

  12. Thermodynamics of anisotropic branes

    Energy Technology Data Exchange (ETDEWEB)

    Ávila, Daniel [Departamento de Física, Facultad de Ciencias, Universidad Nacional Autónoma de México, A.P. 70-542, México D.F. 04510 (Mexico); Fernández, Daniel [Max-Planck-Institut für Physik,Föhringer Ring 6, 80805 München (Germany); Patiño, Leonardo [Departamento de Física, Facultad de Ciencias, Universidad Nacional Autónoma de México, A.P. 70-542, México D.F. 04510 (Mexico); Trancanelli, Diego [Institute of Physics, University of São Paulo,05314-970 São Paulo (Brazil)

    2016-11-22

    We study the thermodynamics of flavor D7-branes embedded in an anisotropic black brane solution of type IIB supergravity. The flavor branes undergo a phase transition between a ‘Minkowski embedding’, in which they lie outside of the horizon, and a ‘black hole embedding’, in which they fall into the horizon. This transition depends on the black hole temperature, its degree of anisotropy, and the mass of the flavor degrees of freedom. It happens either at a critical temperature or at a critical anisotropy. A general lesson we learn from this analysis is that the anisotropy, in this particular realization, induces similar effects as the temperature. In particular, increasing the anisotropy bends the branes more and more into the horizon. Moreover, we observe that the transition becomes smoother for higher anisotropies.

  13. Anisotropic Rabi model

    Directory of Open Access Journals (Sweden)

    Qiong-Tao Xie

    2014-06-01

    Full Text Available We define the anisotropic Rabi model as the generalization of the spin-boson Rabi model: The Hamiltonian system breaks the parity symmetry; the rotating and counterrotating interactions are governed by two different coupling constants; a further parameter introduces a phase factor in the counterrotating terms. The exact energy spectrum and eigenstates of the generalized model are worked out. The solution is obtained as an elaboration of a recently proposed method for the isotropic limit of the model. In this way, we provide a long-sought solution of a cascade of models with immediate relevance in different physical fields, including (i quantum optics, a two-level atom in single-mode cross-electric and magnetic fields; (ii solid-state physics, electrons in semiconductors with Rashba and Dresselhaus spin-orbit coupling; and (iii mesoscopic physics, Josephson-junction flux-qubit quantum circuits.

  14. Bak compensated for Bax in p53-null cells to release cytochrome c for the initiation of mitochondrial signaling during Withanolide D-induced apoptosis.

    Directory of Open Access Journals (Sweden)

    Susmita Mondal

    Full Text Available The goal of cancer chemotherapy to induce multi-directional apoptosis as targeting a single pathway is unable to decrease all the downstream effect arises from crosstalk. Present study reports that Withanolide D (WithaD, a steroidal lactone isolated from Withania somnifera, induced cellular apoptosis in which mitochondria and p53 were intricately involved. In MOLT-3 and HCT116p53+/+ cells, WithaD induced crosstalk between intrinsic and extrinsic signaling through Bid, whereas in K562 and HCT116p53-/- cells, only intrinsic pathway was activated where Bid remain unaltered. WithaD showed pronounced activation of p53 in cancer cells. Moreover, lowered apoptogenic effect of HCT116p53-/- over HCT116p53+/+ established a strong correlation between WithaD-mediated apoptosis and p53. WithaD induced Bax and Bak upregulation in HCT116p53+/+, whereas increase only Bak expression in HCT116p53-/- cells, which was coordinated with augmented p53 expression. p53 inhibition substantially reduced Bax level and failed to inhibit Bak upregulation in HCT116p53+/+ cells confirming p53-dependent Bax and p53-independent Bak activation. Additionally, in HCT116p53+/+ cells, combined loss of Bax and Bak (HCT116Bax-Bak- reduced WithaD-induced apoptosis and completely blocked cytochrome c release whereas single loss of Bax or Bak (HCT116Bax-Bak+/HCT116Bax+Bak- was only marginally effective after WithaD treatment. In HCT116p53-/- cells, though Bax translocation to mitochondria was abrogated, Bak oligomerization helped the cells to release cytochrome c even before the disruption of mitochondrial membrane potential. WithaD also showed in vitro growth-inhibitory activity against an array of p53 wild type and null cancer cells and K562 xenograft in vivo. Taken together, WithaD elicited apoptosis in malignant cells through Bax/Bak dependent pathway in p53-wild type cells, whereas Bak compensated against loss of Bax in p53-null cells.

  15. Rotational discontinuities in anisotropic plasmas

    International Nuclear Information System (INIS)

    Omidi, N.

    1992-01-01

    The kinetic structure of rotational discontinuities (RDs) in anisotropic plasmas with T perpendicular /T parallel > 1 is investigated by using a one-dimensional electromagnetic hybrid code. To form the RD, a new approach is used where the plasma is injected from one boundary and reflected from the other, resulting in the generation of a traveling fast shock and an RD. Unlike the previously used methods, no a priori assumptions are made regarding the initial structure (i.e. width or sense of rotation) of the rotational discontinuity. The results show that across the RD both the magnetic field strength and direction, as well as the plasma density change. Given that such a change can also be associated with an intermediate shock, the Rankine-Hugoniot relations are used to confirm that the observed structures are indeed RDs. It is found that the thickness of RDs is a few ion inertial lengths and is independent of the rotation angle. Also, the preferred sense of rotation is in the electron sense; however, RDs with a rotation angle larger than 180 degree are found to be unstable, changing their rotation to a stable ion sense

  16. Disadvantage factor for anisotropic scattering

    International Nuclear Information System (INIS)

    Saad, E.A.; Abdel Krim, M.S.; EL-Dimerdash, A.A.

    1990-01-01

    The invariant embedding method is used to solve the problem for a two region reactor with anisotropic scattering and to compute the disadvantage factor necessary for calculating some reactor parameters

  17. Photon states in anisotropic media

    Indian Academy of Sciences (India)

    Abstract. Quantum aspects of optical polarization are discussed for waves traveling in anisotropic dielectric media with a view to relate the dynamics of polarization with that of photon spin and its manipulation by classical polarizers.

  18. Anisotropic nonequilibrium hydrodynamic attractor

    Science.gov (United States)

    Strickland, Michael; Noronha, Jorge; Denicol, Gabriel S.

    2018-02-01

    We determine the dynamical attractors associated with anisotropic hydrodynamics (aHydro) and the DNMR equations for a 0 +1 d conformal system using kinetic theory in the relaxation time approximation. We compare our results to the nonequilibrium attractor obtained from the exact solution of the 0 +1 d conformal Boltzmann equation, the Navier-Stokes theory, and the second-order Mueller-Israel-Stewart theory. We demonstrate that the aHydro attractor equation resums an infinite number of terms in the inverse Reynolds number. The resulting resummed aHydro attractor possesses a positive longitudinal-to-transverse pressure ratio and is virtually indistinguishable from the exact attractor. This suggests that an optimized hydrodynamic treatment of kinetic theory involves a resummation not only in gradients (Knudsen number) but also in the inverse Reynolds number. We also demonstrate that the DNMR result provides a better approximation of the exact kinetic theory attractor than the Mueller-Israel-Stewart theory. Finally, we introduce a new method for obtaining approximate aHydro equations which relies solely on an expansion in the inverse Reynolds number. We then carry this expansion out to the third order, and compare these third-order results to the exact kinetic theory solution.

  19. Anisotropic Bianchi-I universe with phantom field and cosmological ...

    Indian Academy of Sciences (India)

    The anisotropy of the universe decreases and the universe transits to an isotropic flat FRW universe accommodating the present acceleration. A class of new cosmological solutions is obtained for an anisotropic universe in case an initial anisotropy exists which is bigger than the value determined by the parameter of the ...

  20. Wave velocities in a pre-stressed anisotropic elastic medium

    Indian Academy of Sciences (India)

    Modified Christoffel equations are derived for three-dimensional wave propagation in a general anisotropic medium under initial stress.The three roots of a cubic equation define the phase velocities of three quasi-waves in the medium.Analytical expressions are used to calculate the directional derivatives of phase ...

  1. Anisotropic dark energy and CMB anomalies

    International Nuclear Information System (INIS)

    Battye, Richard; Moss, Adam

    2009-01-01

    We investigate the breaking of global statistical isotropy caused by a dark energy component with an energy-momentum tensor which has point symmetry, that could represent a cubic or hexagonal crystalline lattice. In such models Gaussian, adiabatic initial conditions created during inflation can lead to anisotropies in the cosmic microwave background whose spherical harmonic coefficients are correlated, contrary to the standard assumption. We develop an adaptation of the line of sight integration method that can be applied to models where the background energy-momentum tensor is isotropic, but whose linearized perturbations are anisotropic. We then show how this can be applied to the cases of cubic and hexagonal symmetry. We compute quantities which show that such models are indistinguishable from isotropic models even in the most extreme parameter choices, in stark contrast to models with anisotropic initial conditions based on inflation. The reason for this is that the dark energy based models contribute to the CMB anisotropy via the integrated Sachs-Wolfe effect, which is only relevant when the dark energy is dominant, that is, on the very largest scales. For inflationary models, however, the anisotropy is present on all scales.

  2. NSAIDs may regulate EGR-1-mediated induction of reactive oxygen species and non-steroidal anti-inflammatory drug-induced gene (NAG)-1 to initiate intrinsic pathway of apoptosis for the chemoprevention of colorectal cancer.

    Science.gov (United States)

    Vaish, Vivek; Piplani, Honit; Rana, Chandan; Vaiphei, Kim; Sanyal, Sankar Nath

    2013-06-01

    This study aims to investigate the unclear molecular relationship involved in the activation of intrinsic pathway of apoptosis and NSAID-activated gene-1 (NAG-1) induction as a putative target in NSAIDs-mediated chemoprevention of colorectal cancer. Male Sprague-Dawley rats were administered with a colon-specific pro-carcinogen, 1,2-dimethylhydrazine dihydrochloride to achieve the early stages of colorectal cancer. Histopathological examination was performed for the analysis of neoplastic lesions while flow cytometry was performed for the relative quantification of intracellular reactive oxygen species (ROS), differential mitochondrial membrane potential (MMP or ΔΨ(M)), and apoptotic events. Various target biomolecules were analyzed either for their mRNA or protein expression profiles via RT-PCR and quantitative Real-Time PCR, or Western blotting and immunofluorescence, respectively. Enhanced gene as well as protein expression of pro-apoptotic agents was observed with the daily oral administration of two NSAIDs viz. Sulindac (cyclooxygenase (COX)-non-specific) and Celecoxib (a selective COX-2 inhibitor). A significant increase in early growth response-1 (EGR-1) protein expression and nuclear localization in NSAIDs co-administered animals may have positively regulated the expression of NAG-1 with a significant enhancement of intracellular ROS in turn decreasing the ΔΨ(M) to initiate apoptosis. In silico molecular docking analysis also showed that Sulindac and Celecoxib can block the active site pocket of B-cell lymphoma-extra large (Bcl-xL, anti-apoptotic transmembrane mitochondrial protein) which could be a putative mechanism followed by these NSAIDs to overcome anti-apoptotic properties of the molecule. NSAIDs-mediated up-regulation of EGR-1 and thereby NAG-1 along with implication of higher ROS load may positively regulate the intrinsic pathway of apoptosis for the chemoprevention of colorectal cancer.

  3. Knockdown of eukaryotic translation initiation factor 4E suppresses cell growth and invasion, and induces apoptosis and cell cycle arrest in a human lung adenocarcinoma cell line.

    Science.gov (United States)

    Chen, Baofu; Zhang, Bo; Xia, Lilong; Zhang, Jian; Chen, Yu; Hu, Quanteng; Zhu, Chengchu

    2015-12-01

    Eukaryotic translation initiation factor 4E (eIF4E) was shown to be upregulated in malignant human tumors. To assess the effect of downregulation of eIF4E on the proliferation and invasiveness of a human lung adenocarcinoma cell line, a short hairpin (sh)RNA targeting eIF4E was constructed and transfected into A549 human lung adenocarcinoma cells. The expression of eIF4E was determined by reverse transcription‑quantitative polymerase chain reaction and western blotting. Cell viability was assessed using a Cell Counting kit‑8, and apoptosis levels and cell cycle distribution were assessed by flow cytometry. Invasiveness was assessed using Transwell chambers. Transfection of the A549 cells with eIF4E targeting shRNA reduced the mRNA and protein expression levels of eIF4E by >70% 48 and 72 h following transfection, and eIF4E targeting shRNA‑transfected cells were significantly less viable compared with the cells transfected with scrambled shRNA. The rate of apoptosis was also significantly increased, significantly more cells were in the G0/G1 phase and fewer were in the S phase, indicating cell cycle arrest. The fraction of transfected cells migrating across Transwell inserts were also reduced. In conclusion, inhibition of eIF4E suppressed cell growth and invasion, induced apoptosis and cell cycle arrest, suggesting that eIF4E may be a potential therapeutic target in lung adenocarcinoma.

  4. Phosphorylation of the α-subunit of the eukaryotic initiation factor-2 (eIF2α) alleviates benzo[a]pyrene-7,8-diol-9,10-epoxide induced cell cycle arrest and apoptosis in human cells.

    Science.gov (United States)

    Wang, Qiaoling; Jiang, Hongjuan; Fan, Yanfeng; Huang, Xiaobin; Shen, Jing; Qi, Hongyan; Li, Qian; Lu, Xiangyun; Shao, Jimin

    2011-01-01

    Benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE) is a carcinogen causing bulky-adduct DNA damage and inducing extensive cell responses regulating cell cycle, cell survival and apoptosis. However, the mechanism of cellular responses to BPDE exposure is not fully understood. In this study, we demonstrated the involvement of the phosphorylation of the α-subunit of the eukaryotic initiation factor-2 (eIF2α) in the cellular response to BPDE exposure and addressed the role of eIF2α phosphorylation in the regulation of the cellular stress. Phosphorylation of eIF2α was induced in a normal human FL amnion epithelial cell line, and the expression of ATF4, a conserved downstream transcriptional factor of eIF2α phosphorylation, was up-regulated after BPDE exposure; however, the four known primary kinases for eIF2α phosphorylation (GCN2, HRI, PKR, and PERK) were not found activated. While BPDE induced severe cell cycle arrest and apoptosis and decreased cell viability in FL cells, salubrinal, a selective inhibitor of eIF2α dephosphorylation, maintained the eIF2α phosphorylation and attenuated cell cycle arrest and apoptosis and promoted cell survival. The findings reveal that when BPDE causes cellular damages, it induces eIF2α phosphorylation as well, which produces a pro-survival and anti-apoptotic effect to alleviate the cellular damages. Thus, the present study proposes a new cellular defensive mechanism during the environmental mutagen and carcinogen attack. Copyright © 2010 Elsevier B.V. All rights reserved.

  5. Continuum mechanics of anisotropic materials

    CERN Document Server

    Cowin, Stephen C

    2013-01-01

    Continuum Mechanics of Anisotropic Materials(CMAM) presents an entirely new and unique development of material anisotropy in the context of an appropriate selection and organization of continuum mechanics topics. These features will distinguish this continuum mechanics book from other books on this subject. Textbooks on continuum mechanics are widely employed in engineering education, however, none of them deal specifically with anisotropy in materials. For the audience of Biomedical, Chemical and Civil Engineering students, these materials will be dealt with more frequently and greater accuracy in their analysis will be desired. Continuum Mechanics of Anisotropic Materials' author has been a leader in the field of developing new approaches for the understanding of anisotropic materials.

  6. Anisotropic hydrodynamics: Motivation and methodology

    Energy Technology Data Exchange (ETDEWEB)

    Strickland, Michael

    2014-06-15

    In this proceedings contribution I review recent progress in our understanding of the bulk dynamics of relativistic systems that possess potentially large local rest frame momentum-space anisotropies. In order to deal with these momentum-space anisotropies, a reorganization of relativistic viscous hydrodynamics can be made around an anisotropic background, and the resulting dynamical framework has been dubbed “anisotropic hydrodynamics”. I also discuss expectations for the degree of momentum-space anisotropy of the quark–gluon plasma generated in relativistic heavy ion collisions at RHIC and LHC from second-order viscous hydrodynamics, strong-coupling approaches, and weak-coupling approaches.

  7. Magnetic relaxation in anisotropic magnets

    DEFF Research Database (Denmark)

    Lindgård, Per-Anker

    1971-01-01

    The line shape and the kinematic and thermodynamic slowing down of the critical and paramagnetic relaxation in axially anisotropic materials are discussed. Kinematic slowing down occurs only in the longitudinal relaxation function. The thermodynamic slowing down occurs in either the transverse...

  8. Failure in imperfect anisotropic materials

    DEFF Research Database (Denmark)

    Legarth, Brian Nyvang

    2005-01-01

    The fundamental cause of crack growth, namely nucleation and growth of voids, is investigated numerically for a two phase imperfect anisotropic material. A unit cell approach is adopted from which the overall stress strain is evaluated. Failure is observed as a sudden stress drop and depending...

  9. Quantum electrodynamics of inhomogeneous anisotropic media

    Energy Technology Data Exchange (ETDEWEB)

    Lopez, Adrian E.R.; Lombardo, Fernando C. [Ciudad Universitaria, Departamento de Fisica Juan Jose Giambiagi, Buenos Aires (Argentina); IFIBA CONICET-UBA, Facultad de Ciencias Exactas y Naturales, Buenos Aires (Argentina)

    2015-02-01

    In this work we calculate the closed time path generating functional for the electromagnetic (EM) field interacting with inhomogeneous anisotropic matter. For this purpose, we first find a general expression for the electromagnetic field's influence action from the interaction of the field with a composite environment consisting in the quantum polarization degrees of freedom in each point of space, at arbitrary temperatures, connected to thermal baths. Then we evaluate the generating functional for the gauge field, in the temporal gauge, by implementing the Faddeev-Popov procedure. Finally, through the point-splitting technique, we calculate closed expressions for the energy, the Poynting vector, and the Maxwell tensor in terms of the Hadamard propagator. We show that all the quantities have contributions from the field's initial conditions and also from the matter degrees of freedom. Throughout the whole work we discuss how the gauge invariance must be treated in the formalism when the EM-field is interacting with inhomogeneous anisotropic matter. We study the electrodynamics in the temporal gauge, obtaining the EM-field's equation and a residual condition. Finally we analyze the case of the EM-field in bulk material and also discuss several general implications of our results in relation with the Casimir physics in a non-equilibrium scenario. (orig.)

  10. Turbulent Output-Based Anisotropic Adaptation

    Science.gov (United States)

    Park, Michael A.; Carlson, Jan-Renee

    2010-01-01

    Controlling discretization error is a remaining challenge for computational fluid dynamics simulation. Grid adaptation is applied to reduce estimated discretization error in drag or pressure integral output functions. To enable application to high O(10(exp 7)) Reynolds number turbulent flows, a hybrid approach is utilized that freezes the near-wall boundary layer grids and adapts the grid away from the no slip boundaries. The hybrid approach is not applicable to problems with under resolved initial boundary layer grids, but is a powerful technique for problems with important off-body anisotropic features. Supersonic nozzle plume, turbulent flat plate, and shock-boundary layer interaction examples are presented with comparisons to experimental measurements of pressure and velocity. Adapted grids are produced that resolve off-body features in locations that are not known a priori.

  11. Metafluid with anisotropic dynamic mass

    International Nuclear Information System (INIS)

    Gumen, L.N.; Arriaga, J.; Krokhin, A.A.

    2011-01-01

    We show that a fluid filling the space between metallic cylinders arranged in a two-dimensional lattice exhibits anisotropic dynamic mass for sound waves propagating through the lattice, if its unit cell is anisotropic. Using the plane-waves expansion method we derive (in the long wavelength limit) a formula for the effective mass tensor of the metafluid. The proposed formula is very general - it is valid for arbitrary Bravais lattices and arbitrary filling fractions of the cylinders. We apply our method to a periodic structure with very high anisotropy, when other known methods fail. In particular, we calculate the effective mass tensor for sound waves in air with embedded lattice of aluminum cylinders having rectangular cross sections, and obtain excellent agreement with experiment. The proposed method of calculation may find numerous applications for tailoring of metafluids with prescribed anisotropy.

  12. Anisotropic Ripple Deformation in Phosphorene.

    Science.gov (United States)

    Kou, Liangzhi; Ma, Yandong; Smith, Sean C; Chen, Changfeng

    2015-05-07

    Two-dimensional materials tend to become crumpled according to the Mermin-Wagner theorem, and the resulting ripple deformation may significantly influence electronic properties as observed in graphene and MoS2. Here, we unveil by first-principles calculations a new, highly anisotropic ripple pattern in phosphorene, a monolayer black phosphorus, where compression-induced ripple deformation occurs only along the zigzag direction in the strain range up to 10%, but not the armchair direction. This direction-selective ripple deformation mode in phosphorene stems from its puckered structure with coupled hinge-like bonding configurations and the resulting anisotropic Poisson ratio. We also construct an analytical model using classical elasticity theory for ripple deformation in phosphorene under arbitrary strain. The present results offer new insights into the mechanisms governing the structural and electronic properties of phosphorene crucial to its device applications.

  13. Exact anisotropic polytropic cylindrical solutions

    Science.gov (United States)

    Sharif, M.; Sadiq, Sobia

    2018-03-01

    In this paper, we study anisotropic compact stars with static cylindrically symmetric anisotropic matter distribution satisfying polytropic equation of state. We formulate the field equations as well as the corresponding mass function for the particular form of gravitational potential z(x)=(1+bx)^{η } (η =1, 2, 3) and explore exact solutions of the field equations for different values of the polytropic index. The values of arbitrary constants are determined by taking mass and radius of compact star (Her X-1). We find that resulting solutions show viable behavior of physical parameters (density, radial as well as tangential pressure, anisotropy) and satisfy the stability condition. It is concluded that physically acceptable solutions exist only for η =1, 2.

  14. Predictions from an anisotropic inflationary era

    International Nuclear Information System (INIS)

    Pitrou, Cyril; Uzan, Jean-Philippe; Pereira, Thiago S

    2008-01-01

    This paper investigates the predictions of an inflationary phase starting from a homogeneous and anisotropic universe of the Bianchi I type. After discussing the evolution of the background spacetime, focusing on the number of e-folds and the isotropization, we solve the perturbation equations and predict the power spectra of the curvature perturbations and gravity waves at the end of inflation. The main features of the early anisotropic phase is (1) a dependence of the spectra on the direction of the modes, (2) a coupling between curvature perturbations and gravity waves and (3) the fact that the two gravity wave polarizations do not share the same spectrum on large scales. All these effects are significant only on large scales and die out on small scales where isotropy is recovered. They depend on a characteristic scale that can, but a priori must not, be tuned to some observable scale. To fix the initial conditions, we propose a procedure that generalizes the one standardly used in inflation but that takes into account the fact that the WKB regime is violated at early times when the shear dominates. We stress that there exist modes that do not satisfy the WKB condition during the shear-dominated regime and for which the amplitude at the end of inflation depends on unknown initial conditions. On such scales, inflation loses its predictability. This study paves the way for the determination of the cosmological signature of a primordial shear, whatever the Bianchi I spacetime. It thus stresses the importance of the WKB regime to draw inflationary predictions and demonstrates that, when the number of e-folds is large enough, the predictions converge toward those of inflation in a Friedmann–Lemaître spacetime but that they are less robust in the case of an inflationary era with a small number of e-folds

  15. Brazilian Tensile Strength of Anisotropic Rocks: Review and New Insights

    Directory of Open Access Journals (Sweden)

    Tianshou Ma

    2018-01-01

    Full Text Available Strength anisotropy is one of the most distinct features of anisotropic rocks, and it also normally reveals strong anisotropy in Brazilian test Strength (“BtS”. Theoretical research on the “BtS” of anisotropic rocks is seldom performed, and in particular some significant factors, such as the anisotropic tensile strength of anisotropic rocks, the initial Brazilian disc fracture points, and the stress distribution on the Brazilian disc, are often ignored. The aim of the present paper is to review the state of the art in the experimental studies on the “BtS” of anisotropic rocks since the pioneering work was introduced in 1964, and to propose a novel theoretical method to underpin the failure mechanisms and predict the “BtS” of anisotropic rocks under Brazilian test conditions. The experimental data of Longmaxi Shale-I and Jixi Coal were utilized to verify the proposed method. The results show the predicted “BtS” results show strong agreement with experimental data, the maximum error is only ~6.55% for Longmaxi Shale-I and ~7.50% for Jixi Coal, and the simulated failure patterns of the Longmaxi Shale-I are also consistent with the test results. For the Longmaxi Shale-I, the Brazilian disc experiences tensile failure of the intact rock when 0° ≤ βw ≤ 24°, shear failure along the weakness planes when 24° ≤ βw ≤ 76°, and tensile failure along the weakness planes when 76° ≤ βw ≤ 90°. For the Jixi Coal, the Brazilian disc experiences tensile failure when 0° ≤ βw ≤ 23° or 76° ≤ βw ≤ 90°, shear failure along the butt cleats when 23° ≤ βw ≤ 32°, and shear failure along the face cleats when 32° ≤ βw ≤ 76°. The proposed method can not only be used to predict the “BtS” and underpin the failure mechanisms of anisotropic rocks containing a single group of weakness planes, but can also be generalized for fractured rocks containing multi-groups of weakness planes.

  16. Anisotropic and nonlinear optical waveguides

    CERN Document Server

    Someda, CG

    1992-01-01

    Dielectric optical waveguides have been investigated for more than two decades. In the last ten years they have had the unique position of being simultaneously the backbone of a very practical and fully developed technology, as well as an extremely exciting area of basic, forefront research. Existing waveguides can be divided into two sets: one consisting of waveguides which are already in practical use, and the second of those which are still at the laboratory stage of their evolution. This book is divided into two separate parts: the first dealing with anisotropic waveguides, an

  17. Anisotropic Hardening Behaviour and Springback of Advanced High-Strength Steels

    Directory of Open Access Journals (Sweden)

    Jaebong Jung

    2017-11-01

    Full Text Available Advanced high-strength steels (AHSSs exhibit large, and sometimes anisotropic, springback recovery after forming. Accurate description of the anisotropic elasto-plastic behaviour of sheet metals is critical for predicting their anisotropic springback behaviour. For some materials, the initial anisotropy is maintained while hardening progresses. However, for other materials, anisotropy changes with hardening. In this work, to account for the evolution of anisotropy of a dual-phase steel, an elastoplastic material constitutive model is developed. In particular, the combined isotropic–kinematic hardening model was modified. Tensile loading–unloading, uniaxial and biaxial tension, and tension–compression tests were conducted along the rolling, diagonal, and transverse directions to measure the anisotropic properties, and the parameters of the proposed constitutive model were determined. For validation, the proposed model was applied to a U-bending process, and the measured springback angles were compared to the predicted ones.

  18. Anisotropic non-Fermi liquids

    Science.gov (United States)

    Sur, Shouvik; Lee, Sung-Sik

    2016-11-01

    We study non-Fermi-liquid states that arise at the quantum critical points associated with the spin density wave (SDW) and charge density wave (CDW) transitions in metals with twofold rotational symmetry. We use the dimensional regularization scheme, where a one-dimensional Fermi surface is embedded in (3 -ɛ ) -dimensional momentum space. In three dimensions, quasilocal marginal Fermi liquids arise both at the SDW and CDW critical points: the speed of the collective mode along the ordering wave vector is logarithmically renormalized to zero compared to that of Fermi velocity. Below three dimensions, however, the SDW and CDW critical points exhibit drastically different behaviors. At the SDW critical point, a stable anisotropic non-Fermi-liquid state is realized for small ɛ , where not only time but also different spatial coordinates develop distinct anomalous dimensions. The non-Fermi liquid exhibits an emergent algebraic nesting as the patches of Fermi surface are deformed into a universal power-law shape near the hot spots. Due to the anisotropic scaling, the energy of incoherent spin fluctuations disperse with different power laws in different momentum directions. At the CDW critical point, on the other hand, the perturbative expansion breaks down immediately below three dimensions as the interaction renormalizes the speed of charge fluctuations to zero within a finite renormalization group scale through a two-loop effect. The difference originates from the fact that the vertex correction antiscreens the coupling at the SDW critical point whereas it screens at the CDW critical point.

  19. Local deposition of anisotropic nanoparticles using scanning electrochemical microscopy (SECM).

    Science.gov (United States)

    Fedorov, Roman G; Mandler, Daniel

    2013-02-28

    We demonstrate localized electrodeposition of anisotropic metal nanoobjects, namely Au nanorods (GNR), on indium tin oxide (ITO) using scanning electrochemical microscopy (SECM). A gold microelectrode was the source of the gold ions whereby double pulse chronoamperometry was employed to generate initially Au seeds which were further grown under controlled conditions. The distance between the microelectrode and the ITO surface as well as the different experimental parameters (electrodeposition regime, solution composition and temperature) were optimized to produce faceted gold seeds with the required characteristics (size and distribution). Colloidal chemical synthesis was successfully exploited for better understanding the role of the surfactant and different additives in breaking the crystallographic symmetry and anisotropic growth of GNR. Experiments performed in a conventional three-electrode cell revealed the most appropriate electrochemical conditions allowing high yield synthesis of nanorods with well-defined shape as well as nanocubes and bipyramids.

  20. Reflection of light from an anisotropic medium

    OpenAIRE

    Ignatovich, Filipp V.; Ignatovich, Vladimir

    2010-01-01

    We present here a general approach to treat reflection and refraction of light of arbitrary polarization from single axis anisotropic plates. We show that reflection from interface inside the anisotropic medium is accompanied by beam splitting and can create surface waves.

  1. Efficient Wavefield Extrapolation In Anisotropic Media

    KAUST Repository

    Alkhalifah, Tariq

    2014-07-03

    Various examples are provided for wavefield extrapolation in anisotropic media. In one example, among others, a method includes determining an effective isotropic velocity model and extrapolating an equivalent propagation of an anisotropic, poroelastic or viscoelastic wavefield. The effective isotropic velocity model can be based upon a kinematic geometrical representation of an anisotropic, poroelastic or viscoelastic wavefield. Extrapolating the equivalent propagation can use isotopic, acoustic or elastic operators based upon the determined effective isotropic velocity model. In another example, non-transitory computer readable medium stores an application that, when executed by processing circuitry, causes the processing circuitry to determine the effective isotropic velocity model and extrapolate the equivalent propagation of an anisotropic, poroelastic or viscoelastic wavefield. In another example, a system includes processing circuitry and an application configured to cause the system to determine the effective isotropic velocity model and extrapolate the equivalent propagation of an anisotropic, poroelastic or viscoelastic wavefield.

  2. Stability of anisotropic stellar filaments

    Science.gov (United States)

    Bhatti, M. Zaeem-ul-Haq; Yousaf, Z.

    2017-12-01

    The study of perturbation of self-gravitating celestial cylindrical object have been carried out in this paper. We have designed a framework to construct the collapse equation by formulating the modified field equations with the background of f(R , T) theory as well as dynamical equations from the contracted form of Bianchi identities with anisotropic matter configuration. We have encapsulated the radial perturbations on metric and material variables of the geometry with some known static profile at Newtonian and post-Newtonian regimes. We examined a strong dependence of unstable regions on stiffness parameter which measures the rigidity of the fluid. Also, the static profile and matter variables with f(R , T) dark source terms control the instability of compact cylindrical system.

  3. Warm anisotropic inflationary universe model

    International Nuclear Information System (INIS)

    Sharif, M.; Saleem, Rabia

    2014-01-01

    This paper is devoted to the study of warm inflation using vector fields in the background of a locally rotationally symmetric Bianchi type I model of the universe. We formulate the field equations, and slow-roll and perturbation parameters (scalar and tensor power spectra as well as their spectral indices) in the slow-roll approximation. We evaluate all these parameters in terms of the directional Hubble parameter during the intermediate and logamediate inflationary regimes by taking the dissipation factor as a function of the scalar field as well as a constant. In each case, we calculate the observational parameter of interest, i.e., the tensor-scalar ratio in terms of the inflaton. The graphical behavior of these parameters shows that the anisotropic model is also compatible with WMAP7 and the Planck observational data. (orig.)

  4. Warm anisotropic inflationary universe model

    Energy Technology Data Exchange (ETDEWEB)

    Sharif, M.; Saleem, Rabia [University of the Punjab, Department of Mathematics, Lahore (Pakistan)

    2014-02-15

    This paper is devoted to the study of warm inflation using vector fields in the background of a locally rotationally symmetric Bianchi type I model of the universe. We formulate the field equations, and slow-roll and perturbation parameters (scalar and tensor power spectra as well as their spectral indices) in the slow-roll approximation. We evaluate all these parameters in terms of the directional Hubble parameter during the intermediate and logamediate inflationary regimes by taking the dissipation factor as a function of the scalar field as well as a constant. In each case, we calculate the observational parameter of interest, i.e., the tensor-scalar ratio in terms of the inflaton. The graphical behavior of these parameters shows that the anisotropic model is also compatible with WMAP7 and the Planck observational data. (orig.)

  5. Effect of anisotropic yield function evolution on formability of sheet metal

    Science.gov (United States)

    Choi, H. J.; Choi, Y.; Lee, K. J.; Lee, J. Y.; Bandyopadhyay, K.; Lee, M.-G.

    2017-10-01

    For the evaluation of anisotropic yield functions and hardening models, formability has been often investigated in the forming of sheet metals. The formability has been investigated in many ways, but a common conclusion is that it is significantly influenced by sheet anisotropy, especially the directional differences in yield stress and r-value along the material direction. Therefore, numerous works have been presented in terms of the accurate modeling of anisotropic behavior of sheet metals and its implementation into the finite element simulations. The previous efforts include the effects of quadratic or non-quadratic yield functions, their associated or non-associated flow rules and isotropic or non-isotropic hardening laws on formability. However, most of these works assumed that the anisotropic yield functions maintain their initial shapes, while they evolve by isotropic expansion or kinematic translation. Then, they could not consider the anisotropic evolution under monotonic loading with different deformation modes. In the present work, various anisotropic constitutive models were comparatively evaluated for the performance in predicting the earing profile in the cup drawing and the forming limit diagram. The constitutive models include the Hill48 quadratic yield function with associated and non-associated flow rules, and the non-quadratic Yld2000-2d function with associated flow rule. For both yield functions, the evolution of anisotropy was employed by considering the anisotropic coefficients as a function of equivalent plastic strain. The influence of the anisotropy evolution was comparatively evaluated by the computational simulations.

  6. Finite-volume scheme for anisotropic diffusion

    Energy Technology Data Exchange (ETDEWEB)

    Es, Bram van, E-mail: bramiozo@gmail.com [Centrum Wiskunde & Informatica, P.O. Box 94079, 1090GB Amsterdam (Netherlands); FOM Institute DIFFER, Dutch Institute for Fundamental Energy Research, The Netherlands" 1 (Netherlands); Koren, Barry [Eindhoven University of Technology (Netherlands); Blank, Hugo J. de [FOM Institute DIFFER, Dutch Institute for Fundamental Energy Research, The Netherlands" 1 (Netherlands)

    2016-02-01

    In this paper, we apply a special finite-volume scheme, limited to smooth temperature distributions and Cartesian grids, to test the importance of connectivity of the finite volumes. The area of application is nuclear fusion plasma with field line aligned temperature gradients and extreme anisotropy. We apply the scheme to the anisotropic heat-conduction equation, and compare its results with those of existing finite-volume schemes for anisotropic diffusion. Also, we introduce a general model adaptation of the steady diffusion equation for extremely anisotropic diffusion problems with closed field lines.

  7. Anisotropic behaviour of human gallbladder walls.

    Science.gov (United States)

    Li, W G; Hill, N A; Ogden, R W; Smythe, A; Majeed, A W; Bird, N; Luo, X Y

    2013-04-01

    Inverse estimation of biomechanical parameters of soft tissues from non-invasive measurements has clinical significance in patient-specific modelling and disease diagnosis. In this paper, we propose a fully nonlinear approach to estimate the mechanical properties of the human gallbladder wall muscles from in vivo ultrasound images. The iteration method consists of a forward approach, in which the constitutive equation is based on a modified Hozapfel-Gasser-Ogden law initially developed for arteries. Five constitutive parameters describing the two orthogonal families of fibres and the matrix material are determined by comparing the computed displacements with medical images. The optimisation process is carried out using the MATLAB toolbox, a Python code, and the ABAQUS solver. The proposed method is validated with published artery data and subsequently applied to ten human gallbladder samples. Results show that the human gallbladder wall is anisotropic during the passive refilling phase, and that the peak stress is 1.6 times greater than that calculated using linear mechanics. This discrepancy arises because the wall thickness reduces by 1.6 times during the deformation, which is not predicted by conventional linear elasticity. If the change of wall thickness is accounted for, then the linear model can used to predict the gallbladder stress and its correlation with pain. This work provides further understanding of the nonlinear characteristics of human gallbladder. Copyright © 2013 Elsevier Ltd. All rights reserved.

  8. Fabrication of anisotropic multifunctional colloidal carriers

    Science.gov (United States)

    Jerri, Huda A.

    The field of colloidal assembly has grown tremendously in recent years, although the direct or template-assisted methods used to fabricate complex colloidal constructions from monodisperse micro- and nanoparticles have been generally demonstrated on model materials. In this work, novel core particle syntheses, particle functionalizations and bottom-up assembly techniques are presented to create functional colloidal devices. Using particle lithography, high-information colloidal vectors have been developed and modified with imaging and targeting agents. Localized nanoscale patches have been reliably positioned on microparticles to serve as foundations for further chemical or physical modifications. Site-specific placement of RGD targeting ligands has been achieved in these lithographed patches. Preferential uptake of these targeted vectors by RGD-specific 3T3 fibroblasts was verified using confocal laser scanning microscopy. A transition was made from the functionalization of model imaging core particles to the lithography of colloidal cartridges, in an effort to construct colloidal syringes with specialized, programmable release profiles. A variety of functional, pH-sensitive fluorescent cores were engineered to respond to solution conditions. When triggered, the diverse composite core microparticles and reservoir microcapsules released embedded fluorescent moieties such as dye molecules, and fluorophore-conjugated nanoparticles. The microcapsules, created using layer-by-layer polyelectrolyte deposition on sacrificial templates, were selectively modified with a robust coating. The pH-responsive anisotropic reservoir microcapsules were extremely stable in solution, and exhibited a "Lazarus" functionality of rehydrating to their original state following desiccation. A snapshot of focused-release of core constituents through the lone opening in colloidal monotremes has been obtained by anisotropically-functionalizing degradable cores with barrier shells. Additionally

  9. Evasion of apoptosis by DNA viruses.

    Science.gov (United States)

    Cuff, S; Ruby, J

    1996-12-01

    Apoptosis is a form of cell death distinct from necrosis which plays an important role in processes such as homoeostasis and the elimination of damaged cells. It can be triggered by a variety of stimuli including DNA damage and cytotoxic T lymphocyte activity, both of which may be induced in the course of a viral infection. Initially, induction of apoptosis may occur through pathways which have also been shown to be activated on disturbance of the cell cycle or damage to cellular DNA. At later time points during the course of infection, apoptosis can also be triggered by cytokines and immune effector cells. Apoptosis of the host cell before the completion of the viral replication cycle may limit the number of progeny and the spread of infection. The importance of apoptosis as an antiviral defence is illustrated by the presence of multiple pathways for apoptosis induction and inhibition in both the host and virus. In this review, the inhibition of apoptosis is described in adenovirus and poxvirus infection. These examples illustrate two of the divergent paths by which viruses may avoid the apoptotic response.

  10. Viscous anisotropic hydrodynamics for the Gubser flow

    Science.gov (United States)

    Martinez, M.; McNelis, M.; Heinz, U.

    2017-11-01

    In this work we describe the dynamics of a highly anisotropic system undergoing boost-invariant longitudinal and azimuthally symmetric radial expansion (Gubser flow) for arbitrary shear viscosity to entropy density ratio. We derive the equations of motion of dissipative anisotropic hydrodynamics by applying to this situation the moments method recently derived by Molnár et al. (MNR) [E. Molnar, H. Niemi, and D. H. Rischke, "Derivation of anisotropic dissipative fluid dynamics from the Boltzmann equation," Phys. Rev. D93 no. 11, (2016) 114025, arxiv:arXiv:1602.00573 [nucl-th], E. Molnar, H. Niemi, and D. H. Rischke, "Closing the equations of motion of anisotropic fluid dynamics by a judicious choice of a moment of the Boltzmann equation," Phys. Rev. D94 no. 12, (2016) 125003, arxiv:arXiv:1606.09019 [nucl-th

  11. Anisotropic magnetoresistance in a Fermi glass

    International Nuclear Information System (INIS)

    Ovadyahu, Z.; Physics Department, Ben-Gurion University of the Negev, Beer-Sheva, Israel 84120)

    1986-01-01

    Insulating thin films of indium oxide exhibit negative, anisotropic magnetoresistance. The systematics of these results imply that the magnetoresistance mechanism may give different weight to the distribution of the localization lengths than that given by the hopping conductivity

  12. On the existence of anisotropic cosmological models in higher order theories of gravity

    International Nuclear Information System (INIS)

    Middleton, Jonathan

    2010-01-01

    We investigate the behaviour on approach to the initial singularity in higher order extensions of general relativity by finding exact cosmological solutions for a wide class of models in which the Lagrangian is allowed to depend nonlinearly upon the three possible linear and quadratic scalars built from the Riemann tensor: R, R ab R ab and R abcd R abcd . We present new anisotropic vacuum solutions analogous to the Kasner solutions of general relativity and extend previous results to a much wider range of fourth-order theories of gravity. We discuss the implications of these results for the behaviour of the more general anisotropic Bianchi type VIII and IX cosmologies as the initial singularity is approached. Furthermore, we also consider the existence conditions for some other simple anisotropic Bianchi I vacuum solutions in which the expansion in each direction is of exponential, rather than power-law behaviour and their relevance for cosmic 'no-hair' theorems.

  13. Modelling Coulomb Collisions in Anisotropic Plasmas

    Science.gov (United States)

    Hellinger, P.; Travnicek, P. M.

    2009-12-01

    Collisional transport in anisotropic plasmas is investigated comparing the theoretical transport coefficients (Hellinger and Travnicek, 2009) for anisotropic particles with the results of the corresponding Langevin equation, obtained as a generalization of Manheimer et al. (1997). References: Hellinger, P., and P. M. Travnicek (2009), On Coulomb collisions in bi-Maxwellian plasmas, Phys. Plasmas, 16, 054501. Manheimer, W. M., M. Lampe and G. Joyce (1997), Langevin representation of Coulomb collisions in PIC simulations, J. Comput. Phys., 138, 563-584.

  14. Anisotropic rectangular metric for polygonal surface remeshing

    KAUST Repository

    Pellenard, Bertrand

    2013-06-18

    We propose a new method for anisotropic polygonal surface remeshing. Our algorithm takes as input a surface triangle mesh. An anisotropic rectangular metric, defined at each triangle facet of the input mesh, is derived from both a user-specified normal-based tolerance error and the requirement to favor rectangle-shaped polygons. Our algorithm uses a greedy optimization procedure that adds, deletes and relocates generators so as to match two criteria related to partitioning and conformity.

  15. Penetration effect in uniaxial anisotropic metamaterials

    Science.gov (United States)

    Vytovtov, K.; Barabanova, E.; Zouhdi, S.

    2018-02-01

    Plane harmonic wave propagation along an interface between vacuum and a semi-infinite anisotropic metamaterial is considered. Possibility of penetration effect in the considered case is studied. It is shown that there is a bulk wave within the anisotropic metamaterial with an arbitrary orientation of the anisotropy axis. It is also proved that a reflected wave must propagate perpendicularly to the interface in the case of the extraordinary wave. Moreover, no wave is reflected in the case of ordinary wave propagation.

  16. An anisotropic elastoplasticity model implemented in FLAG

    Energy Technology Data Exchange (ETDEWEB)

    Buechler, Miles Allen [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Canfield, Thomas R. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-10-12

    Many metals, including Tantalum and Zirconium, exhibit anisotropic elastoplastic behavior at the single crystal level, and if components are manufactured from these metals through forming processes the polycrystal (component) may also exhibit anisotropic elastoplastic behavior. This is because the forming can induce a preferential orientation of the crystals in the polycrystal. One example is a rolled plate of Uranium where the sti /strong orientation of the crystal (c-axis) tends to align itself perpendicular to the rolling direction. If loads are applied to this plate in di erent orientations the sti ness as well as the ow strength of the material will be greater in the through thickness direction than in other directions. To better accommodate simulations of such materials, an anisotropic elastoplasticity model has been implemented in FLAG. The model includes an anisotropic elastic stress model as well as an anisotropic plasticity model. The model could represent single crystals of any symmetry, though it should not be confused with a high- delity crystal plasticity model with multiple slip planes and evolutions. The model is most appropriate for homogenized polycrystalline materials. Elastic rotation of the material due to deformation is captured, so the anisotropic models are appropriate for arbitrary large rotations, but currently they do not account for signi cant change in material texture beyond the elastic rotation of the entire polycrystal.

  17. Self-assembly in the systems of magnetic anisotropic nanoparticles

    Science.gov (United States)

    Gudkova, A. V.; Pyanzina, E. S.

    2017-11-01

    This paper presents the complex investigation of the system of magnetic anisotropic nanoparticles using computer simulations in a wide range of the system's parameters. The cluster analysis was made, various average characteristics of the formed clusters were calculated and the initial magnetic susceptibility and the radial distribution function were computed. It was shown that via changing the nanoparticles characteristics (their shape and the values of the magnetic moments) it's possible to change macroscopic response of the system, that implements the idea of tuning and design new materials with controllable properties.

  18. Quantum cosmology in an anisotropic n -dimensional universe

    Science.gov (United States)

    Alves-Júnior, F. A. P.; Pucheu, M. L.; Barreto, A. B.; Romero, C.

    2018-02-01

    We investigate quantum cosmological models in an n -dimensional anisotropic universe in the presence of a massless scalar field. Our basic inspiration comes from Chodos and Detweiler's classical model, which predicts interesting behavior of the extra dimension, shrinking down as time goes by. We work in the framework of a recent geometrical scalar-tensor theory of gravity. Classically, we obtain two distinct types of solutions. One of them has an initial singularity, while the other represents a static universe considered as a whole. By using the canonical approach to quantum cosmology, we investigate how quantum effects could have had an influence in the past history of these universes.

  19. Mechanics of anisotropic spring networks.

    Science.gov (United States)

    Zhang, T; Schwarz, J M; Das, Moumita

    2014-12-01

    We construct and analyze a model for a disordered linear spring network with anisotropy. The modeling is motivated by, for example, granular systems, nematic elastomers, and ultimately cytoskeletal networks exhibiting some underlying anisotropy. The model consists of a triangular lattice with two different bond occupation probabilities, p(x) and p(y), for the linear springs. We develop an effective medium theory (EMT) to describe the network elasticity as a function of p(x) and p(y). We find that the onset of rigidity in the EMT agrees with Maxwell constraint counting. We also find beyond linear behavior in the shear and bulk modulus as a function of occupation probability in the rigid phase for small strains, which differs from the isotropic case. We compare our EMT with numerical simulations to find rather good agreement. Finally, we discuss the implications of extending the reach of effective medium theory as well as draw connections with prior work on both anisotropic and isotropic spring networks.

  20. Apoptosis of neutrophils

    NARCIS (Netherlands)

    Maianski, N. A.; Maianski, A. N.; Kuijpers, T. W.; Roos, D.

    2004-01-01

    Regulation of the neutrophil life span by apoptosis provides a fine balance between their function as effector cells of host defense and a safe turnover of these potentially harmful cells. Alterations of neutrophil apoptosis are associated with a number of diseases. As do other cell types,

  1. Ubiquitination in apoptosis signaling

    NARCIS (Netherlands)

    van de Kooij, L.W.

    2014-01-01

    The work described in this thesis focuses on ubiquitination and protein degradation, with an emphasis on how these processes regulate apoptosis signaling. More specifically, our aims were: 1. To increase the understanding of ubiquitin-mediated regulation of apoptosis signaling. 2. To identify the E3

  2. Hyperthermia-induced apoptosis

    NARCIS (Netherlands)

    Nijhuis, E.H.A.

    2008-01-01

    This thesis describes a number of studies that investigated several aspects of heat-induced apoptosis in human lymphoid malignancies. Cells harbour both pro- and anti-apoptotic proteins and the balance between these proteins determines whether a cell is susceptible to undergo apoptosis. In this

  3. Bound dipole solitary solutions in anisotropic nonlocal self-focusing media

    DEFF Research Database (Denmark)

    Mamaev, A.V.; Zozulya, A.A.; Mezentsev, V.K.

    1997-01-01

    We find and analyze bound dipole solitary solutions in media with anisotropic nonlocal photorefractive material response. The dipole solutions consist of two elliptically shaped Gaussian-type beams separated by several diameters, and with a pi phase shift between their fields. Spatial evolution...... of two initially round Gaussian beams and their convergence to the above dipole solution is demonstrated experimentally....

  4. Necking of anisotropic micro-films with strain-gradient effects

    DEFF Research Database (Denmark)

    Legarth, Brian Nyvang

    2008-01-01

    Necking of stubby micro-films of aluminum is investigated numerically by considering tension of a specimen with an initial imperfection used to onset localisation. Plastic anisotropy is represented by two different yield criteria and strain-gradient effects are accounted for using the visco......-plastic finite strain model. Furthermore, the model is extended to isotropic anisotropic hardening (evolving anisotropy). For isotropic hardening plastic anisotropy affects the predicted overall nominal stress level, while the peak stress remains at an overall logarithmic strain corresponding to the hardening...... exponent. This holds true for both local and nonlocal materials. Anisotropic hardening delays the point of maximum overall nominal stress....

  5. Existence and uniqueness of global solutions for the modified anisotropic 3D Navier−Stokes equations

    KAUST Repository

    Bessaih, Hakima

    2016-01-27

    We study a modified three-dimensional incompressible anisotropic Navier−Stokes equations. The modification consists in the addition of a power term to the nonlinear convective one. This modification appears naturally in porous media when a fluid obeys the Darcy−Forchheimer law instead of the classical Darcy law. We prove global in time existence and uniqueness of solutions without assuming the smallness condition on the initial data. This improves the result obtained for the classical 3D incompressible anisotropic Navier−Stokes equations.

  6. Molecular Mechanism of Apoptosis and Necrosis

    Directory of Open Access Journals (Sweden)

    Gulfidan Coskun

    2011-06-01

    Full Text Available Organismal homeostasis depends on an intricate balance between cell death and renewal. Apoptosis is a process of programmed cell death that plays a critical role in some normal and pathologic conditions beginning from embryologic development and ends at death. Apoptosis is initiated by morphological changes at the cell membrane, surface organels and nucleus. Apoptosis starts with death signals coming from outside or inside of the cell and continue to activate the mechanisms of apoptosis via cell death receptor or mitochondrial pathways. During apoptosis a group proteases are activated which cause DNA fragmentation, cytoplasmic shrinkage and membrane blebbing. Apoptotic cells divide into apoptotic bodies and then these apoptotic bodies are removed from tissue by phagocytes and adjacent cells In contrast to the “programmed” nature of apoptosis, necrotic cell death has always been believed to be a random, uncontrolled process that leads to death of the cell. Also necrosis, which is an other type of cell death, came to be used to describe pathologic cell death which cause inflamation. [Archives Medical Review Journal 2011; 20(3.000: 145-158

  7. Anisotropic nanomaterials: structure, growth, assembly, and functions

    Science.gov (United States)

    Sajanlal, Panikkanvalappil R.; Sreeprasad, Theruvakkattil S.; Samal, Akshaya K.; Pradeep, Thalappil

    2011-01-01

    Comprehensive knowledge over the shape of nanomaterials is a critical factor in designing devices with desired functions. Due to this reason, systematic efforts have been made to synthesize materials of diverse shape in the nanoscale regime. Anisotropic nanomaterials are a class of materials in which their properties are direction-dependent and more than one structural parameter is needed to describe them. Their unique and fine-tuned physical and chemical properties make them ideal candidates for devising new applications. In addition, the assembly of ordered one-dimensional (1D), two-dimensional (2D), and three-dimensional (3D) arrays of anisotropic nanoparticles brings novel properties into the resulting system, which would be entirely different from the properties of individual nanoparticles. This review presents an overview of current research in the area of anisotropic nanomaterials in general and noble metal nanoparticles in particular. We begin with an introduction to the advancements in this area followed by general aspects of the growth of anisotropic nanoparticles. Then we describe several important synthetic protocols for making anisotropic nanomaterials, followed by a summary of their assemblies, and conclude with major applications. PMID:22110867

  8. Effective medium theory for anisotropic metamaterials

    KAUST Repository

    Zhang, Xiujuan

    2015-01-20

    Materials with anisotropic material parameters can be utilized to fabricate many fascinating devices, such as hyperlenses, metasolids, and one-way waveguides. In this study, we analyze the effects of geometric anisotropy on a two-dimensional metamaterial composed of a rectangular array of elliptic cylinders and derive an effective medium theory for such a metamaterial. We find that it is possible to obtain a closed-form analytical solution for the anisotropic effective medium parameters, provided the aspect ratio of the lattice and the eccentricity of the elliptic cylinder satisfy certain conditions. The derived effective medium theory not only recovers the well-known Maxwell-Garnett results in the quasi-static regime, but is also valid beyond the long-wavelength limit, where the wavelength in the host medium is comparable to the size of the lattice so that previous anisotropic effective medium theories fail. Such an advance greatly broadens the applicable realm of the effective medium theory and introduces many possibilities in the design of structures with desired anisotropic material characteristics. A real sample of a recently theoretically proposed anisotropic medium, with a near-zero index to control the flux, is achieved using the derived effective medium theory, and control of the electromagnetic waves in the sample is clearly demonstrated.

  9. A cortical locus for anisotropic overlay suppression of stimuli presented at fixation.

    Science.gov (United States)

    Hansen, Bruce C; Richard, Bruno; Andres, Kristin; Johnson, Aaron P; Thompson, Benjamin; Essock, Edward A

    2015-01-01

    Human contrast sensitivity for narrowband Gabor targets is suppressed when superimposed on narrowband masks of the same spatial frequency and orientation (referred to as overlay suppression), with suppression being broadly tuned to orientation and spatial frequency. Numerous behavioral and neurophysiological experiments have suggested that overlay suppression originates from the initial lateral geniculate nucleus (LGN) inputs to V1, which is consistent with the broad tuning typically reported for overlay suppression. However, recent reports have shown narrowly tuned anisotropic overlay suppression when narrowband targets are masked by broadband noise. Consequently, researchers have argued for an additional form of overlay suppression that involves cortical contrast gain control processes. The current study sought to further explore this notion behaviorally using narrowband and broadband masks, along with a computational neural simulation of the hypothesized underlying gain control processes in cortex. Additionally, we employed transcranial direct current stimulation (tDCS) in order to test whether cortical processes are involved in driving narrowly tuned anisotropic suppression. The behavioral results yielded anisotropic overlay suppression for both broadband and narrowband masks and could be replicated with our computational neural simulation of anisotropic gain control. Further, the anisotropic form of overlay suppression could be directly modulated by tDCS, which would not be expected if the suppression was primarily subcortical in origin. Altogether, the results of the current study provide further evidence in support of an additional overlay suppression process that originates in cortex and show that this form of suppression is also observable with narrowband masks.

  10. Head-wave coefficients in anisotropic media

    Science.gov (United States)

    Chapman, Chris

    2018-03-01

    Reflections and transmissions from interfaces can generate head waves. Although the kinematic properties of head waves are modelled simply using ray concepts, the dynamic properties require an extension of ray theory or the use of wave theory. Head waves are important in exploration and crustal seismology as they indicate the existence of an interface and the velocity of the generating wave. Head waves have been described in the literature for isotropic media but the extension to anisotropic media seems to be lacking. The expressions for the head-wave coefficients using ray concepts or wave theory differ, and their equality is not obvious. This paper extends the theory for head-wave coefficients to anisotropic media using both ray theory and wave theory, and generalizes the proof of equality of the two methods. Simple numerical examples confirm this equality and indicate how the head-wave results can be calculated in anisotropic media and included in a ray-tracing algorithm.

  11. Elastic properties of spherically anisotropic piezoelectric composites

    International Nuclear Information System (INIS)

    En-Bo, Wei; Guo-Qing, Gu; Ying-Ming, Poon

    2010-01-01

    Effective elastic properties of spherically anisotropic piezoelectric composites, whose spherically anisotropic piezoelectric inclusions are embedded in an infinite non-piezoelectric matrix, are theoretically investigated. Analytical solutions for the elastic displacements and the electric potentials under a uniform external strain are derived exactly. Taking into account of the coupling effects of elasticity, permittivity and piezoelectricity, the formula is derived for estimating the effective elastic properties based on the average field theory in the dilute limit. An elastic response mechanism is revealed, in which the effective elastic properties increase as inclusion piezoelectric properties increase and inclusion dielectric properties decrease. Moreover, a piezoelectric response mechanism, of which the effective piezoelectric response vanishes due to the symmetry of spherically anisotropic composite, is also disclosed. (condensed matter: structure, thermal and mechanical properties)

  12. Obtuse triangle suppression in anisotropic meshes

    KAUST Repository

    Sun, Feng

    2011-12-01

    Anisotropic triangle meshes are used for efficient approximation of surfaces and flow data in finite element analysis, and in these applications it is desirable to have as few obtuse triangles as possible to reduce the discretization error. We present a variational approach to suppressing obtuse triangles in anisotropic meshes. Specifically, we introduce a hexagonal Minkowski metric, which is sensitive to triangle orientation, to give a new formulation of the centroidal Voronoi tessellation (CVT) method. Furthermore, we prove several relevant properties of the CVT method with the newly introduced metric. Experiments show that our algorithm produces anisotropic meshes with much fewer obtuse triangles than using existing methods while maintaining mesh anisotropy. © 2011 Elsevier B.V. All rights reserved.

  13. Generalized Fractional Derivative Anisotropic Viscoelastic Characterization

    Directory of Open Access Journals (Sweden)

    Harry H. Hilton

    2012-01-01

    Full Text Available Isotropic linear and nonlinear fractional derivative constitutive relations are formulated and examined in terms of many parameter generalized Kelvin models and are analytically extended to cover general anisotropic homogeneous or non-homogeneous as well as functionally graded viscoelastic material behavior. Equivalent integral constitutive relations, which are computationally more powerful, are derived from fractional differential ones and the associated anisotropic temperature-moisture-degree-of-cure shift functions and reduced times are established. Approximate Fourier transform inversions for fractional derivative relations are formulated and their accuracy is evaluated. The efficacy of integer and fractional derivative constitutive relations is compared and the preferential use of either characterization in analyzing isotropic and anisotropic real materials must be examined on a case-by-case basis. Approximate protocols for curve fitting analytical fractional derivative results to experimental data are formulated and evaluated.

  14. Anisotropic nanomaterials preparation, properties, and applications

    CERN Document Server

    Li, Quan

    2015-01-01

    In this book anisotropic one-dimensional and two-dimensional nanoscale building blocks and their assembly into fascinating and qualitatively new functional structures embracing both hard and soft components are explained. Contributions from leading experts regarding important aspects like synthesis, assembly, properties and applications of the above materials are compiled into a reference book. The anisotropy, i.e. the direction-dependent physical properties, of materials is fascinating and elegant and has sparked the quest for anisotropic materials with useful properties. With such a curiosi

  15. Modelling of CMUTs with Anisotropic Plates

    DEFF Research Database (Denmark)

    la Cour, Mette Funding; Christiansen, Thomas Lehrmann; Jensen, Jørgen Arendt

    2012-01-01

    Traditionally, CMUTs are modelled using the isotropic plate equation and this leads to deviations between analytical calculations and FEM simulations. In this paper, the deflection profile and material parameters are calculated using the anisotropic plate equation. It is shown that the anisotropic...... calculations match perfectly with FEM while an isotropic approach causes up to 10% deviations in deflection profile. Furthermore, we show how commonly used analytic modelling methods such as static calculations of the pull-in voltage and dynamic modelling through an equivalent circuit representation can...

  16. Apoptosis – is it good or bad?

    Directory of Open Access Journals (Sweden)

    Bakir Mehić

    2012-08-01

    induced by TNF-α. The over expression of antiapoptotic proteins may allow injured cells to survive, and autophagy may assist by providing critical metabolites. Apoptotic cells induce anergy or an immunosuppressive phenotype, whereas necrotic cells augment inflammation, in part by binding the receptor C-type lectin domain family 9 on dendritic cells.Clinical implications of apoptosis are consist in more than 50% of neoplasm’s that have defects in the apoptotic machinery mutations in the tumor-suppressor gene TP53, that is called the “guardian of the genome,” initiates apoptosis in response to DNA damage induced by radiation, chemical agents, oxidative stress, and other agents.[3] Abnormalities in apoptosis can increase susceptibility to autoimmune diseases.[4] There is growing evidence that neuronal apoptosis plays a key role in neonatal brain disorders.[5] Hepatocytes are particularly prone to apoptosis in response to various types of stress, including infections.[6] Necrosis predominates in ischemic injury, but often there are apoptotic cells in the hypoxic penumbra in myocardial infarction and stroke and in globally hypoxic zones after reperfusion injury. Sepsis is perhaps the most remarkable clinical setting in which apoptosis occurs. Massive apoptosis of immune effectors’ cells and gastrointestinal epithelial cells develops in patients with sepsis.[7] The profound loss of immune effectors’ cells in sepsis inhibits the ability of the immune system to eradicate the primary infection and renders the patient susceptible to nosocomial infections. Finally, why apoptosis is good? Because without apoptosis, 2 tons of bone marrow and lymph nodes and a 16-km intestine would probably accumulate in a human by the age of 8o.[8

  17. Apoptosis in Pneumovirus Infection

    Directory of Open Access Journals (Sweden)

    Reinout A. Bem

    2013-01-01

    Full Text Available Pneumovirus infections cause a wide spectrum of respiratory disease in humans and animals. The airway epithelium is the major site of pneumovirus replication. Apoptosis or regulated cell death, may contribute to the host anti-viral response by limiting viral replication. However, apoptosis of lung epithelial cells may also exacerbate lung injury, depending on the extent, the timing and specific location in the lungs. Differential apoptotic responses of epithelial cells versus innate immune cells (e.g., neutrophils, macrophages during pneumovirus infection can further contribute to the complex and delicate balance between host defense and disease pathogenesis. The purpose of this manuscript is to give an overview of the role of apoptosis in pneumovirus infection. We will examine clinical and experimental data concerning the various pro-apoptotic stimuli and the roles of apoptotic epithelial and innate immune cells during pneumovirus disease. Finally, we will discuss potential therapeutic interventions targeting apoptosis in the lungs.

  18. Reaper-Induced Apoptosis

    National Research Council Canada - National Science Library

    Perry, Jennifer

    2005-01-01

    Reaper is a central regulator of apoptosis in the fly, Drosophila melanogaster. At the start of this proposal our laboratory identified what was believed to be a pro-apoptotic human homolog of Reaper...

  19. Viruses and apoptosis.

    Science.gov (United States)

    Roulston, A; Marcellus, R C; Branton, P E

    1999-01-01

    Successful viral replication requires not only the efficient production and spread of progeny, but also evasion of host defense mechanisms that limit replication by killing infected cells. In addition to inducing immune and inflammatory responses, infection by most viruses triggers apoptosis or programmed cell death of the infected cell. This cell response often results as a compulsory or unavoidable by-product of the action of critical viral replicative functions. In addition, some viruses seem to use apoptosis as a mechanism of cell killing and virus spread. In both cases, successful replication relies on the ability of certain viral products to block or delay apoptosis until sufficient progeny have been produced. Such proteins target a variety of strategic points in the apoptotic pathway. In this review we summarize the great amount of recent information on viruses and apoptosis and offer insights into how this knowledge may be used for future research and novel therapies.

  20. A Variational Approach to Perturbed Discrete Anisotropic Equations

    Directory of Open Access Journals (Sweden)

    Amjad Salari

    2016-01-01

    Full Text Available We continue the study of discrete anisotropic equations and we will provide new multiplicity results of the solutions for a discrete anisotropic equation. We investigate the existence of infinitely many solutions for a perturbed discrete anisotropic boundary value problem. The approach is based on variational methods and critical point theory.

  1. The Effect of Anisotropic Scatter on Atmospheric Neutron Transport

    Science.gov (United States)

    2015-03-26

    THE EFFECT OF ANISOTROPIC SCATTER ON ATMOSPHERIC NEUTRON TRANSPORT THESIS MARCH 2015 Nicholas J...iii AFIT-ENP-MS-15-M-085 THE EFFECT OF ANISOTROPIC SCATTER ON ATMOSPHERIC NEUTRON TRANSPORT THESIS Presented to the...EFFECT OF ANISOTROPIC SCATTER ON ATMOSPHERIC NEUTRON TRANSPORT Nicholas J. McIntee, BSE Major, USA Committee Membership: Dr. Kirk A. Mathews

  2. Anisotropic cosmological models in f

    Indian Academy of Sciences (India)

    A class of non-singular bouncing cosmological models of a general class of Bianchi models filled with perfect fluid in the framework of f ( R , T ) gravity is presented. The model initially accelerates for a certain period of time and decelerates thereafter. The physical behaviour of the model is also studied.

  3. Eukaryotic translation initiation factor 2 subunit α (eIF2α) inhibitor salubrinal attenuates paraquat-induced human lung epithelial-like A549 cell apoptosis by regulating the PERK-eIF2α signaling pathway.

    Science.gov (United States)

    Wang, Rui; Sun, Da-Zhuang; Song, Chun-Qing; Xu, Yong-Min; Liu, Wei; Liu, Zhi; Dong, Xue-Song

    2018-02-01

    Paraquat (PQ), as one of the most widely used herbicides in the world, can cause severe lung damage in humans and animals. This study investigated the underlying molecular mechanism of PQ-induced lung cell damage and the protective role of salubrinal. Human lung epithelial-like A549 cells were treated with PQ for 24h and were pre-incubated with salubrinal for 2h, followed by 500μM of PQ treatment. Silencing eIF2α gene of the A549 cells with siRNA interference method was conducted. Cell morphology, cell viability, apoptosis and caspase-3 activity were assessed by different assays accordingly thereafter. The expression of PERK, p-PERK, ATF6, c-ATF6, IRE1α, p-IRE1α, CHOP, GRP78, p-eIF2α and β-actin was assayed by western blot. The data showed that PQ significantly reduced A549 cell viability, changed cell morphology, induced cell apoptosis and significantly upregulated the levels of GRP78, CHOP, p-PERK, c-ATF6 and p-IRE1α. However, 30μM salubrinal could attenuate the effects of PQ on damages to A549 cells through upregulating p-eIF2α. In contrast, knocking down eIF2α gene inhabited the effects of salubrinal. These results suggest that PQ-induced A549 cell apoptosis involved endoplasmic reticulum (ER) stress, specially the PERK-eIF2α pathway. Salubrinal attenuated A549 cells from PQ-induced damages through regulation of the PERK-eIF2α signaling. Copyright © 2017 Elsevier Ltd. All rights reserved.

  4. Hypersurface-homogeneous cosmological models with anisotropic ...

    Indian Academy of Sciences (India)

    2016-12-05

    Dec 5, 2016 ... DOI 10.1007/s12043-016-1317-4. Hypersurface-homogeneous cosmological models with anisotropic dark energy in Saez–Ballester theory of gravitation. M K VERMA1, S CHANDEL2 and SHRI RAM2,∗. 1Department of Mathematics, Baba Banarasi Das National Institute of Technology & Management,.

  5. Anisotropic Hanle line shape via magnetothermoelectric phenomena

    NARCIS (Netherlands)

    Das, Kumar; Dejene, Fasil; van Wees, Bart; Vera Marun, Ivan

    2016-01-01

    We observe anisotropic Hanle line shape with unequal in-plane and out-of-plane nonlocal signals for spin precession measurements carried out on lateral metallic spin valves with transparent interfaces. The conventional interpretation for this anisotropy corresponds to unequal spin relaxation times

  6. Adaptive slices for acquisition of anisotropic BRDF

    Czech Academy of Sciences Publication Activity Database

    Vávra, Radomír; Filip, Jiří

    (2018) ISSN 2096-0433 R&D Projects: GA ČR GA17-18407S Institutional support: RVO:67985556 Keywords : anisotropic BRDF * slice * sampling Subject RIV: BD - Theory of Information http://library.utia.cas.cz/separaty/2018/RO/vavra-0486116.pdf

  7. Theory of anisotropic diamagnetism, local moment magnetization ...

    Indian Academy of Sciences (India)

    Theory of anisotropic diamagnetism, local moment magnetization and carrier spin-polarization in Pb1-EuTe ... Gopalpur 761 002, India; Department of Physics, Jagannath Institute for Technology and Management, Parlakhemundi 761 211, India; Department of Physics, Berhampur University, Berhampur 760 007, India ...

  8. Hypersurface-homogeneous cosmological models with anisotropic ...

    Indian Academy of Sciences (India)

    The present study deals with hypersurface-homogeneous cosmological models with anisotropic dark energy in Saez–Ballester theory of gravitation. Exact solutions of field equations are obtained by applying a special law of variation of Hubble's parameter that yields a constant negative value of the deceleration parameter.

  9. Minimally coupled scalar field cosmology in anisotropic ...

    Indian Academy of Sciences (India)

    We study a spatially homogeneous and anisotropic cosmological model in the Einstein gravitational theory with a minimally coupled scalar field. We consider a non-interacting combination of scalar field and perfect fluid as the source of matter components which are separately conserved. The dynamics of cosmic scalar ...

  10. Algebraic solution of an anisotropic nonquadratic potential

    International Nuclear Information System (INIS)

    Boschi Filho, H.; Vaidya, A.N.

    1990-06-01

    We show that an anisotropic nonquadratic potential, for which a path integral treatment had been recently discussed in the literature, possesses the (SO(2,1)xSO(2,1))ΛSO(2,1) dynamical symmetry and constructs its Green function algebraically. A particular case which generates new eigenvalues and eigenfunctions is also discussed. (author). 11 refs

  11. Modelling anisotropic water transport in polymer composite

    Indian Academy of Sciences (India)

    This work reports anisotropic water transport in a polymer composite consisting of an epoxy matrix reinforced with aligned triangular bars made of vinyl ester. By gravimetric experiments, water diffusion in resin and polymer composites were characterized. Parameters for Fickian diffusion and polymer relaxation models were ...

  12. A new algorithm for anisotropic solutions

    Indian Academy of Sciences (India)

    We establish a new algorithm that generates a new solution to the Einstein field equations, with an anisotropic matter distribution, from a seed isotropic solution. The new solution is expressed in terms of integrals of an isotropic gravitational potential; and the integration can be completed exactly for particular isotropic seed ...

  13. Acoustic reflection from the boundary of anisotropic ...

    Indian Academy of Sciences (India)

    Vertical slownesses of waves at a boundary of an anisotropic thermoviscoelastic medium are calculated as roots of a polynomial equation of degree eight. Out of the corresponding eight waves, the four, which travel towards the boundary are identified as upgoing waves. Remaining four waves travel away from the boundary ...

  14. Ray tracing in anisotropic media with singularities

    Czech Academy of Sciences Publication Activity Database

    Vavryčuk, Václav

    2001-01-01

    Roč. 145, č. 1 (2001), s. 265-276 ISSN 0956-540X R&D Projects: GA ČR GA205/00/1350 Institutional research plan: CEZ:AV0Z3012916 Keywords : anisotropic media * ray tracing * singularities Subject RIV: DC - Siesmology, Volcanology, Earth Structure Impact factor: 1.366, year: 2001

  15. Minimally coupled scalar field cosmology in anisotropic ...

    Indian Academy of Sciences (India)

    2017-01-03

    Jan 3, 2017 ... a phantom field [24,25], quintom [26,27], k-essence. [28], tachyon [29] and so forth. It is well known that the evolution of the Uni- verse admits a scenario of anisotropic expansion and gains a lot of interest, under the light of the recently announced Planck Probe results [7]. The Bianchi models, which describe ...

  16. Modelling anisotropic water transport in polymer composite ...

    Indian Academy of Sciences (India)

    Abstract. This work reports anisotropic water transport in a polymer composite consisting of an epoxy matrix reinforced with aligned triangular bars made of vinyl ester. By gravimetric experiments, water diffusion in resin and polymer composites were characterized. Parameters for Fickian diffusion and polymer relaxation ...

  17. The method of images for anisotropic media

    International Nuclear Information System (INIS)

    Iosilevskii, Ya.A.

    1978-01-01

    The method of images is suggested to construct a scalar macroscopic field (dynamic or static) of a point source in an anisotropic half-space or flat slab. The field is found for an arbitrary orientation of the boundaries with respect to the crystallographic axes. (Auth.)

  18. Level Set Approach to Anisotropic Wet Etching of Silicon

    Directory of Open Access Journals (Sweden)

    Branislav Radjenović

    2010-05-01

    Full Text Available In this paper a methodology for the three dimensional (3D modeling and simulation of the profile evolution during anisotropic wet etching of silicon based on the level set method is presented. Etching rate anisotropy in silicon is modeled taking into account full silicon symmetry properties, by means of the interpolation technique using experimentally obtained values for the etching rates along thirteen principal and high index directions in KOH solutions. The resulting level set equations are solved using an open source implementation of the sparse field method (ITK library, developed in medical image processing community, extended for the case of non-convex Hamiltonians. Simulation results for some interesting initial 3D shapes, as well as some more practical examples illustrating anisotropic etching simulation in the presence of masks (simple square aperture mask, convex corner undercutting and convex corner compensation, formation of suspended structures are shown also. The obtained results show that level set method can be used as an effective tool for wet etching process modeling, and that is a viable alternative to the Cellular Automata method which now prevails in the simulations of the wet etching process.

  19. The structure and dynamics of polymer nanocomposites containing anisotropic nanoparticles

    Science.gov (United States)

    Lin, Chia-Chun; Ohno, Kohji; Clarke, Nigel; Winey, Karen; Composto, Russell; Hore, Michael

    2014-03-01

    The tracer diffusion of deuterated polystyrene (dPS; 49-532 kg/mol) is measured in polystyrene (PS: 270 kg/mol) nanocomposites containing PS-grafted (132 kg/mol) anisotropic nanoparticles (NP). The NP's are small aggregates containing iron oxide spheres (5nm). These NP's uniformly disperse in PS up to 100% loading. The structure of the polymer nanocomposites is probed using (ultra)small angle x-ray scattering (USAXS,SAXS). Peaks shift to high Q region with increasing NP loadings, indicating a decrease in spacing between particles. The interparticle distance for the pure NP case is 30nm, consistent with TEM, and a brush thickness of 15nm. The brush profile is also measured using SANS. The reduced tracer diffusion coefficient initially decreases as NP loadings increase and then reaches a minimum (35% reduction) near 0.25 vol% (core) for all dPS. With a further increase in NP loading, diffusion recovers to 90% of the unfilled case. Penetration of the tracer (i.e., wetting) into the brush will affect the effective interparticle distance. Diffusion of dPS (1866 kg/mol) will be examined to determine if the dry brush case influences the recovery at high loading. These experiments demonstrate that polymer brushes grafted to anisotropic nano particles can affect the tracer diffusion pathway and indicate that diffusion models should incorporate the interfacial structure between brush and matrix.

  20. Flow shapes and higher harmonics in anisotropic transverse collective flow

    Energy Technology Data Exchange (ETDEWEB)

    Argintaru, Danut; Baban, Valerica [Constanta Maritime University, Faculty of Navigation and Naval Transport, Constanta (Romania); Besliu, Calin; Jipa, Alexandru; Grossu, Valeriu [University of Bucharest, Faculty of Physics, Bucharest (Romania); Esanu, Tiberiu; Cherciu, Madalin [Institute of Space Sciences Bucharest-Magurele, Bucharest (Romania)

    2017-01-15

    In this paper we show that by using a jet-finder algorithm (the Anti-k{sub T} one) on UrQMD/C simulated (Au+Au at 4, 10 and 15A GeV) collisions, we can identify different flow shape structures (single flow stream events, two flow streams events, three flow streams events, etc.) and order the bulk of events in equivalence flow shape classes. Considering these flow streams as the main directions of anisotropic transverse flow, we show that the Fourier coefficients v{sub n} of anisotropic flow are better emphasized when we analyze the different event flow shape classes than when the events are mixed. Also, if we do not know the real orientation of the reaction plane, we can use as reference the Flow stream 1 - the main particle flow stream - orientation (Ψ{sub Flowstream} {sub 1}) to highlight the initial shape of the participant nuclear matter in a central to peripheral collision, and the orientation of the participant plane of order n. (orig.)

  1. Autophagy and apoptosis in planarians.

    Science.gov (United States)

    González-Estévez, Cristina; Saló, Emili

    2010-03-01

    Adult planarians are capable of undergoing regeneration and body remodelling in order to adapt to physical damage or extreme environmental conditions. Moreover, most planarians can tolerate long periods of starvation and during this time, they shrink from an adult size to, and sometimes beyond, the initial size at hatching. Indeed, these properties have made them a classic model to study stem cells and regeneration. Under such stressful conditions, food reserves from the gastrodermis and parenchyma are first used up and later the testes, copulatory organs and ovaries are digested. More surprisingly, when food is again made available to shrunken individuals, they grow back to adult size and all their reproductive structures reappear. These cycles of growth and shrinkage may occur over long periods without any apparent impairment to the individual, or to its future maturation and breeding capacities. This plasticity resides in a mesoderm tissue known as the parenchyma, which is formed by several differentiated non-proliferating cell types and only one mitotically active cell type, the neoblasts, which represent approximately 20-30% of the cells in the parenchyma. Neoblasts are generally thought to be somatic stem-cells that participate in the normal continuous turnover of all cell types in planarians. Hence, planarians are organisms that continuously adapt their bodies (morphallaxis) to different environmental stresses (i.e.: injury or starvation). This adaptation involves a variety of processes including proliferation, differentiation, apoptosis and autophagy, all of which are perfectly orchestrated and tightly regulated to remodel or restore the body pattern. While neoblast biology and body re-patterning are currently the subject of intense research, apoptosis and autophagy remain much less studied. In this review we will summarize our current understanding and hypotheses regarding where and when apoptosis and autophagy occur and fulfil an essential role in

  2. Views on the Anisotropic Nature of Ilva Valley Region

    Directory of Open Access Journals (Sweden)

    GABRIELA-ALINA MUREŞAN

    2012-01-01

    Full Text Available There are two concepts important for the authors of this article: anisotropic region and anisotropic space. Anisotropic region is defined by A. Dauphiné, the geographer (-mathematician, as a territorial unit whose structure results from the organisation of space along one or more axes. From the point of view of a territorial system, this type of region has some characteristics which differentiate it both from the homogeneous region and from the polarised one. These specificities have been analysed for Ilva Valley. The region of Ilva Valley is formed along the morphological axis represented by the Ilva River. The aim is to identify these specificities or their absence within this region. In this way we can determine whether this region is an anisotropic one or just an anisotropic space, namely whether it can be considered as evolving towards an anisotropic region, not yet complying with all characteristics of anisotropic regions.

  3. Spaceflight Associated Apoptosis

    Science.gov (United States)

    Ichiki, Albert T.; Gibson, Linda A.; Allebban, Zuhair

    1996-01-01

    Lymphoid tissues have been shown to atrophy in rats flown on Russian spaceflights. Histological examination indicated evidence for cell degradation. Lymphoid tissues from rats flown on Spacelab Life Sciences-2 mission were analyzed for apoptosis by evidence of fragmented lymphocytes, which could be engulfed by macrophages, or DNA strand breaks using the terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) assay. Apoptosis was not detected in the thymus and spleen collected inflight or from the synchronous ground rats but was detected in the thymus, spleen and inguinal lymph node of the flight animals on recovery. These results indicate that the apoptosis observed in the lymphatic tissues of the rats on recovery could have been induced by the gravitational stress of reentry, corroborating the findings from the early space-flight observations.

  4. Jet quenching effects on the anisotropic flow at RHIC

    Energy Technology Data Exchange (ETDEWEB)

    Andrade, R.P.G. [Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Santo André, SP, 09210-170 (Brazil); Noronha, J. [Instituto de Física, Universidade de São Paulo, C.P. 66318, 05315-970 São Paulo, SP (Brazil); Denicol, Gabriel S. [Department of Physics, McGill University, 3600 University Street, Montreal, Quebec, H3A 2T8 (Canada)

    2014-12-15

    In this article we investigate how the energy and momentum deposited by partonic dijets in the quark–gluon plasma may perturb the geometry-induced hydrodynamic expansion of the bulk nuclear matter created in heavy ion collisions at the RHIC. The coupling between the jets and the medium is done through a source term in the energy–momentum conservation equations for ideal hydrodynamics. We concentrate our attention at mid-rapidity and solve the equations event-by-event imposing boost-invariance. For p{sub T}≳1 GeV the anisotropic flow is found to be considerably enhanced, if the dijets deposit on average more than 12 GeV in the medium (or equivalently 6 GeV for each jet of the pair), which corresponds, in our model, to an average suppression greater than 65% of the initial jet transverse energy.

  5. Cosmological signatures of anisotropic spatial curvature

    Energy Technology Data Exchange (ETDEWEB)

    Pereira, Thiago S. [Departamento de Física, Universidade Estadual de Londrina, 86057-970, Londrina – PR (Brazil); Marugán, Guillermo A. Mena [Instituto de Estructura de la Materia, IEM-CSIC, Serrano 121, 28006, Madrid (Spain); Carneiro, Saulo, E-mail: tspereira@uel.br, E-mail: mena@iem.cfmac.csic.es, E-mail: saulo.carneiro@pq.cnpq.br [Instituto de Física, Universidade Federal da Bahia, 40210-340, Salvador – BA (Brazil)

    2015-07-01

    If one is willing to give up the cherished hypothesis of spatial isotropy, many interesting cosmological models can be developed beyond the simple anisotropically expanding scenarios. One interesting possibility is presented by shear-free models in which the anisotropy emerges at the level of the curvature of the homogeneous spatial sections, whereas the expansion is dictated by a single scale factor. We show that such models represent viable alternatives to describe the large-scale structure of the inflationary universe, leading to a kinematically equivalent Sachs-Wolfe effect. Through the definition of a complete set of spatial eigenfunctions we compute the two-point correlation function of scalar perturbations in these models. In addition, we show how such scenarios would modify the spectrum of the CMB assuming that the observations take place in a small patch of a universe with anisotropic curvature.

  6. Equilibrium-Based Nonhomogeneous Anisotropic Beam Element

    DEFF Research Database (Denmark)

    Krenk, Steen; Couturier, Philippe

    2017-01-01

    The stiffness matrix and the nodal forces associated with distributed loads are obtained for a nonhomogeneous anisotropic elastic beam element by the use of complementary energy. The element flexibility matrix is obtained by integrating the complementary-energy density corresponding to six beam...... equilibrium states, and then inverted and expanded to provide the element-stiffness matrix. Distributed element loads are represented via corresponding internal-force distributions in local equilibrium with the loads. The element formulation does not depend on assumed shape functions and can, in principle......, include any variation of cross-sectional properties and load variation, provided that these are integrated with sufficient accuracy in the process. The ability to represent variable cross-sectional properties, coupling from anisotropic materials, and distributed element loads is illustrated by numerical...

  7. Polar Functions for Anisotropic Gaussian Random Fields

    Directory of Open Access Journals (Sweden)

    Zhenlong Chen

    2014-01-01

    Full Text Available Let X be an (N, d-anisotropic Gaussian random field. Under some general conditions on X, we establish a relationship between a class of continuous functions satisfying the Lipschitz condition and a class of polar functions of X. We prove upper and lower bounds for the intersection probability for a nonpolar function and X in terms of Hausdorff measure and capacity, respectively. We also determine the Hausdorff and packing dimensions of the times set for a nonpolar function intersecting X. The class of Gaussian random fields that satisfy our conditions includes not only fractional Brownian motion and the Brownian sheet, but also such anisotropic fields as fractional Brownian sheets, solutions to stochastic heat equation driven by space-time white noise, and the operator-scaling Gaussian random field with stationary increments.

  8. Wireless energy transfer between anisotropic metamaterials shells

    Energy Technology Data Exchange (ETDEWEB)

    Díaz-Rubio, Ana; Carbonell, Jorge; Sánchez-Dehesa, José, E-mail: jsdehesa@upv.es

    2014-06-15

    The behavior of strongly coupled Radial Photonic Crystals shells is investigated as a potential alternative to transfer electromagnetic energy wirelessly. These sub-wavelength resonant microstructures, which are based on anisotropic metamaterials, can produce efficient coupling phenomena due to their high quality factor. A configuration of selected constitutive parameters (permittivity and permeability) is analyzed in terms of its resonant characteristics. The coupling to loss ratio between two coupled resonators is calculated as a function of distance, the maximum (in excess of 300) is obtained when the shells are separated by three times their radius. Under practical conditions an 83% of maximum power transfer has been also estimated. -- Highlights: •Anisotropic metamaterial shells exhibit high quality factors and sub-wavelength size. •Exchange of electromagnetic energy between shells with high efficiency is analyzed. •Strong coupling is supported with high wireless transfer efficiency. •End-to-end energy transfer efficiencies higher than 83% can be predicted.

  9. The shear viscosity in anisotropic phases

    Energy Technology Data Exchange (ETDEWEB)

    Jain, Sachin [Department of Physics, Cornell University,Ithaca, New York 14853 (United States); Samanta, Rickmoy; Trivedi, Sandip P. [Department of Theoretical Physics, Tata Institute of Fundamental Research,Colaba, Mumbai 400005 (India)

    2015-10-06

    We construct anisotropic black brane solutions and analyse the behaviour of some of their metric perturbations. These solutions correspond to field theory duals in which rotational symmetry is broken due an externally applied, spatially constant, force. We find, in several examples, that when the anisotropy is sufficiently big compared to the temperature, some components of the viscosity tensor can become very small in units of the entropy density, parametrically violating the KSS bound. We obtain an expression relating these components of the viscosity, in units of the entropy density, to a ratio of metric components at the horizon of the black brane. This relation is generally valid, as long as the forcing function is translationally invariant, and it directly connects the parametric violation of the bound to the anisotropy in the metric at the horizon. Our results suggest the possibility that such small components of the viscosity tensor might also arise in anisotropic strongly coupled fluids found in nature.

  10. Anisotropic instability of a stretching film

    Science.gov (United States)

    Xu, Bingrui; Li, Minhao; Deng, Daosheng

    2017-11-01

    Instability of a thin liquid film, such as dewetting arising from Van der Waals force, has been well studied, and is typically characterized by formation of many droplets. Interestingly, a thin liquid film subjected to an applied stretching during a process of thermal drawing is evolved into an array of filaments, i.e., continuity is preserved along the direction of stretching while breakup occurs exclusively in the plane of cross section. Here, to understand this anisotropic instability, we build a physical model by considering both Van der Waals force and the effect of stretching. By using the linear instability analysis method and then performing a numerical calculation, we find that the growth rate of perturbations at the cross section is larger than that along the direction of stretching, resulting in the anisotropic instability of the stretching film. These results may provide theoretical guidance to achieve more diverse structures for nanotechnology.

  11. Anisotropic magnetocapacitance in ferromagnetic-plate capacitors

    Science.gov (United States)

    Haigh, J. A.; Ciccarelli, C.; Betz, A. C.; Irvine, A.; Novák, V.; Jungwirth, T.; Wunderlich, J.

    2015-04-01

    The capacitance of a parallel-plate capacitor can depend on the applied magnetic field. Previous studies have identified capacitance changes induced via classical Lorentz force or spin-dependent Zeeman effects. Here we measure a magnetization direction-dependent capacitance in parallel-plate capacitors where one plate is a ferromagnetic semiconductor, gallium manganese arsenide. This anisotropic magnetocapacitance is due to the anisotropy in the density of states dependent on the magnetization through the strong spin-orbit interaction.

  12. Symmetry analysis for anisotropic field theories

    International Nuclear Information System (INIS)

    Parra, Lorena; Vergara, J. David

    2012-01-01

    The purpose of this paper is to study with the help of Noether's theorem the symmetries of anisotropic actions for arbitrary fields which generally depend on higher order spatial derivatives, and to find the corresponding current densities and the Noether charges. We study in particular scale invariance and consider the cases of higher derivative extensions of the scalar field, electrodynamics and Chern-Simons theory.

  13. Anisotropic diffusion tensor applied to temporal mammograms

    DEFF Research Database (Denmark)

    Karemore, Gopal; Brandt, Sami; Sporring, Jon

    2010-01-01

    changes related to  specific  effects  like  Hormonal  Replacement  Therapy  (HRT) and aging. Given effect-grouped patient data, we demonstrated how  anisotropic  diffusion  tensor  and  its  coherence  features computed in an anatomically oriented breast coordinate system followed by statistical learning...

  14. Anisotropic conducting films for electromagnetic radiation applications

    Science.gov (United States)

    Cavallo, Francesca; Lagally, Max G.; Rojas-Delgado, Richard

    2015-06-16

    Electronic devices for the generation of electromagnetic radiation are provided. Also provided are methods for using the devices to generate electromagnetic radiation. The radiation sources include an anisotropic electrically conducting thin film that is characterized by a periodically varying charge carrier mobility in the plane of the film. The periodic variation in carrier mobility gives rise to a spatially varying electric field, which produces electromagnetic radiation as charged particles pass through the film.

  15. Electromagnetic field representation in inhomogeneous anisotropic media

    Science.gov (United States)

    Mohsen, A.

    1973-01-01

    Some of the basic developments in the theory of electromagnetic field representation in terms of Hertz vectors are reviewed. A solution for the field in an inhomogeneous anisotropic medium is given in terms of the two Hertz vectors. Conditions for presentation of the field in terms of uncoupled transverse electric and transverse magnetic modes, in a general orthogonal coordinate system, are derived when the permeability and permittivity tensors have only diagonal components. These conditions are compared with some known special cases.

  16. Acoustic anisotropic wavefields through perturbation theory

    KAUST Repository

    Alkhalifah, Tariq Ali

    2013-09-01

    Solving the anisotropic acoustic wave equation numerically using finite-difference methods introduces many problems and media restriction requirements, and it rarely contributes to the ability to resolve the anisotropy parameters. Among these restrictions are the inability to handle media with η<0 and the presence of shear-wave artifacts in the solution. Both limitations do not exist in the solution of the elliptical anisotropic acoustic wave equation. Using perturbation theory in developing the solution of the anisotropic acoustic wave equation allows direct access to the desired limitation-free solutions, that is, solutions perturbed from the elliptical anisotropic background medium. It also provides a platform for parameter estimation because of the ability to isolate the wavefield dependency on the perturbed anisotropy parameters. As a result, I derive partial differential equations that relate changes in the wavefield to perturbations in the anisotropy parameters. The solutions of the perturbation equations represented the coefficients of a Taylor-series-type expansion of the wavefield as a function of the perturbed parameter, which is in this case η or the tilt of the symmetry axis. The expansion with respect to the symmetry axis allows use of an acoustic transversely isotropic media with a vertical symmetry axis (VTI) kernel to estimate the background wavefield and the corresponding perturbation coefficients. The VTI extrapolation kernel is about one-fourth the cost of the transversely isotropic model with a tilt in the symmetry axis kernel. Thus, for a small symmetry axis tilt, the cost of migration using a first-order expansion can be reduced. The effectiveness of the approach was demonstrated on the Marmousi model.

  17. Anisotropic cosmological solutions in massive vector theories

    International Nuclear Information System (INIS)

    Heisenberg, Lavinia; Kase, Ryotaro; Tsujikawa, Shinji

    2016-01-01

    In beyond-generalized Proca theories including the extension to theories higher than second order, we study the role of a spatial component v of a massive vector field on the anisotropic cosmological background. We show that, as in the case of the isotropic cosmological background, there is no additional ghostly degrees of freedom associated with the Ostrogradski instability. In second-order generalized Proca theories we find the existence of anisotropic solutions on which the ratio between the anisotropic expansion rate Σ and the isotropic expansion rate H remains nearly constant in the radiation-dominated epoch. In the regime where Σ/ H is constant, the spatial vector component v works as a dark radiation with the equation of state close to 1/3. During the matter era, the ratio Σ/ H decreases with the decrease of v . As long as the conditions |Σ| || H and v 2 || φ 2 are satisfied around the onset of late-time cosmic acceleration, where φ is the temporal vector component, we find that the solutions approach the isotropic de Sitter fixed point (Σ = 0 = v ) in accordance with the cosmic no-hair conjecture. In the presence of v and Σ the early evolution of the dark energy equation of state w DE in the radiation era is different from that in the isotropic case, but the approach to the isotropic value w DE (iso) typically occurs at redshifts z much larger than 1. Thus, apart from the existence of dark radiation, the anisotropic cosmological dynamics at low redshifts is similar to that in isotropic generalized Proca theories. In beyond-generalized Proca theories the only consistent solution to avoid the divergence of a determinant of the dynamical system corresponds to v = 0, so Σ always decreases in time.

  18. Bryan's effect and anisotropic nonlinear damping

    Science.gov (United States)

    Joubert, Stephan V.; Shatalov, Michael Y.; Fay, Temple H.; Manzhirov, Alexander V.

    2018-03-01

    In 1890, G. H. Bryan discovered the following: "The vibration pattern of a revolving cylinder or bell revolves at a rate proportional to the inertial rotation rate of the cylinder or bell." We call this phenomenon Bryan's law or Bryan's effect. It is well known that any imperfections in a vibratory gyroscope (VG) affect Bryan's law and this affects the accuracy of the VG. Consequently, in this paper, we assume that all such imperfections are either minimised or eliminated by some known control method and that only damping is present within the VG. If the damping is isotropic (linear or nonlinear), then it has been recently demonstrated in this journal, using symbolic analysis, that Bryan's law remains invariant. However, it is known that linear anisotropic damping does affect Bryan's law. In this paper, we generalise Rayleigh's dissipation function so that anisotropic nonlinear damping may be introduced into the equations of motion. Using a mixture of numeric and symbolic analysis on the ODEs of motion of the VG, for anisotropic light nonlinear damping, we demonstrate (up to an approximate average), that Bryan's law is affected by any form of such damping, causing pattern drift, compromising the accuracy of the VG.

  19. ARTc: Anisotropic reflectivity and transmissivity calculator

    Science.gov (United States)

    Malehmir, Reza; Schmitt, Douglas R.

    2016-08-01

    While seismic anisotropy is known to exist within the Earth's crust and even deeper, isotropic or even highly symmetric elastic anisotropic assumptions for seismic imaging is an over-simplification which may create artifacts in the image, target mis-positioning and hence flawed interpretation. In this paper, we have developed the ARTc algorithm to solve reflectivity, transmissivity as well as velocity and particle polarization in the most general case of elastic anisotropy. This algorithm is able to provide reflectivity solution from the boundary between two anisotropic slabs with arbitrary symmetry and orientation up to triclinic. To achieve this, the algorithm solves full elastic wave equation to find polarization, slowness and amplitude of all six wave-modes generated from the incident plane-wave and welded interface. In the first step to calculate the reflectivity, the algorithm solves properties of the incident wave such as particle polarization and slowness. After calculation of the direction of generated waves, the algorithm solves their respective slowness and particle polarization. With this information, the algorithm then solves a system of equations incorporating the imposed boundary conditions to arrive at the scattered wave amplitudes, and thus reflectivity and transmissivity. Reflectivity results as well as slowness and polarization are then tested in complex computational anisotropic models to ensure their accuracy and reliability. ARTc is coded in MATLAB ® and bundled with an interactive GUI and bash script to run on single or multi-processor computers.

  20. ANALYSIS OF DEFORMABILITY OF ANISOTROPIC AGRILLITE CLAYSTONES

    Directory of Open Access Journals (Sweden)

    Ponomaryov Andrey Budimirovicn

    2017-08-01

    Full Text Available In the paper, the results of deformability study of agrillite claystones are used for determination of the Jointed rock model parameters. The number of stamp, pressuremeter and compressive tests allowed to research anisotropic deformability of argillite claystone in vertical and horizontal direction. The following problems were solved during the study: 1 the in-place and laboratory experiments to calculate the anisotropy coefficient were done for anisotropic agrillite claystones with both natural moisture and total water saturation; 2 the deformation parameters were determined and the numerical simulation of the stress-strain state of claystone in field tests was carried out with the use of Plaxis 2D software application; 3 the comparative analysis was done for calculated claystone deformation and the values obtained during the in-place tests. The authors proved that agrillite claystones shows two times less deformation under loading in the horizontal direction than vertically. The ratio is obtained to determine the parameters for numerical simulation of the Jointed Rock model used as a practical tool for analysis of stress-strain behavior of anisotropic soils. The authors provided a recommended practice for consideration of specific properties of argillite claystones when carrying out foundation works.

  1. Three-dimensional magnetotelluric modeling in anisotropic media using edge-based finite element method

    Science.gov (United States)

    Xiao, Tiaojie; Liu, Yun; Wang, Yun; Fu, Li-Yun

    2018-02-01

    It is important to understand how magnetotelluric (MT) modeling can most effectively be performed in general anisotropic media. However, previous studies in this area have mainly focused on the use of one-dimensional (1D) and two-dimensional (2D) algorithms. Thus, building on earlier work, it is important to study the performance of three-dimensional (3D) modeling in arbitrary conductivity media; therefore, an edge-based finite element (FE) method has been developed for 3D MT modeling in arbitrary conductivity media. This approach is based on the initial derivation of a series of equivalent variational equations that are based on Maxwell equations, generated using the weighted residual method. Specific values were then obtained for coefficient matrixes of this edge-based FE method using hexahedral meshes, and the algorithm was verified by comparing its results with finite difference (FD) solutions generated using a 2D anisotropic model. Finally, the results of a 3D anisotropic model were analyzed detailed for three conditions; another 3D anisotropic model was designed and its results were compared with two isotropic models'.

  2. Mitochondria in neutrophil apoptosis

    NARCIS (Netherlands)

    van Raam, B. J.; Verhoeven, A. J.; Kuijpers, T. W.

    2006-01-01

    Central in the regulation of the short life span of neutrophils are their mitochondria. These organelles hardly contribute to the energy status of neutrophils but play a vital role in the apoptotic process. Not only do the mitochondria contain cytotoxic proteins that are released during apoptosis

  3. Apoptosis and inflammation

    Directory of Open Access Journals (Sweden)

    C. Haanen

    1995-01-01

    Full Text Available During the last few decades it has been recognized that cell death is not the consequence of accidental injury, but is the expression of a cell suicide programme. Kerr et al. (1972 introduced the term apoptosis. This form of cell death is under the influence of hormones, growth factors and cytokines, which depending upon the receptors present on the target cells, may activate a genetically controlled cell elimination process. During apoptosis the cell membrane remains intact and the cell breaks into apoptotic bodies, which are phagocytosed. Apoptosis, in contrast to necrosis, is not harmful to the host and does not induce any inflammatory reaction. The principal event that leads to inflammatory disease is cell damage, induced by chemical/physical injury, anoxia or starvation. Cell damage means leakage of cell contents into the adjacent tissues, resulting in the capillary transmigration of granulocytes to the injured tissue. The accumulation of neutrophils and release of enzymes and oxygen radicals enhances the inflammatory reaction. Until now there has been little research into the factors controlling the accumulation and the tissue load of granulocytes and their histotoxic products in inflammatory processes. Neutrophil apoptosis may represent an important event in the control of intlamtnation. It has been assumed that granulocytes disintegrate to apoptotic bodies before their fragments are removed by local macrophages. Removal of neutrophils from the inflammatory site without release of granule contents is of paramount importance for cessation of inflammation. In conclusion, apoptotic cell death plays an important role in inflammatory processes and in the resolution of inflammatory reactions. The facts known at present should stimulate further research into the role of neutrophil, eosinophil and macrophage apoptosis in inflammatory diseases.

  4. Understanding conoscopic interference patterns in anisotropic crystals

    Science.gov (United States)

    Olorunsola, Oluwatobi Gabriel

    The interference patterns observed in conoscopy are important in studying the optical and geometrical properties of anisotropic materials. They have also been used to identify minerals and to explore the structure of biological tissues. In a conoscopic interferometer, an optically anisotropic specimen is placed between two crossed linear polarizers and illuminated by a convergent light beam. The interference patterns are produced because in an anisotropic material an incident light is split into two eigenwaves, namely the ordinary and the extraordinary waves. We report our work on the theoretical simulation and experimental observation of the conoscopic interference patterns in anisotropic crystals. In our simulation, the interference patterns are decomposed into fringes of isogyres and isochromates. For each light propagation direction inside the crystal there exist two eigenwaves that have their own characteristic velocities and vibration directions. The isogyres are obtained by computing the angle between the polarization of the incident light and the vibration directions of the two eigenwaves. The isochromates are obtained by computing the phase retardance between the two eigenwaves inside the crystal. The interference patterns are experimentally observed in several crystals, with their optic axes either parallel or perpendicular to their surfaces. An external electric field is applied to deform the crystals from uniaxial to biaxial. The results of our experimental observation agree well with our computer simulation. In conventional interferometers the isochromatic interference fringes are observed by using a circular polarizer and a circular analyzer, both constructed by a linear polarizer and a quarter wave plate. However, due to the dispersion of the quarter wave plates, the phase-retardance between the two light waves inside the quarter wave plates is wavelength-dependent, which results in different conoscopic interference patterns for different colors of

  5. Anisotropic 3D delay-damage model to simulate concrete structures

    OpenAIRE

    Gatuingt , Fabrice; Desmorat , Rodrigue; Chambart , Marion; Combescure , Didier; Guilbaud , Daniel

    2008-01-01

    International audience; High dynamic loadings lead to material degradation and structural failure. This is even more the case for concrete structures where the parts initially in compression break in ten- sion due to waves propagation and reflection. The dissymmetry of the material behavior plays a major role in such cases, dissymmetry mainly due to damage induced anisotropy. Loading induced damage is most often anisotropic and one proposes here to take advantage of such a feature to build a ...

  6. Polycyclic’ Aromatic Hydrocarbon Induced Intracellular Signaling and Lymphocyte Apoptosis

    DEFF Research Database (Denmark)

    Schneider, Alexander M.

    lymphocytes. Our experiments on preB lymphocytes supported by stromal cells suggest that apoptosis is one of the mechanisms for PAH immunosuppression. It could be either due to direct effect of the PAH on the B cells, via stromal cell signaling. Ubiquitous PAH-like toxin, fluoranthene, was tested for it......’s ability to initiate apoptosis in T cell hybridomas. Our data demonstrate that PAH may induce apoptosis and innnunotoxicity in T cell branch of immune system. The mechanism of this process seems to be the AhR independent, and mediated by Ca...

  7. Fullerene and apoptosis

    Directory of Open Access Journals (Sweden)

    M. A. Orlova

    2013-01-01

    Full Text Available Fullerene derivatives superfamily attracts a serious attention as antiviral and anticancer agents and drug delivery carriers as well. A large number of such fullerene С60 derivatives obtained to date. However, there is an obvious deficit of information about causes and mechanisms of immediately and long-term consequences of their effects in vivo which is a true obstacle on the way leading to practical medical use of them. First, this concerns their impact on the proliferation, apoptosis and necrosis regulation. Fullerene nanoparticle functionalization type, their sizes and surface nanopathology are of great importance to further promoting of either cytoprotective or cytotoxic effects. This lecture provides modern concept analysis regarding fullerenes effects on apoptosis pathway in normal and tumor cells.

  8. Bisphenol A induces spermatocyte apoptosis in rare minnow Gobiocypris rarus

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Yingying; Cheng, Mengqian; Wu, Lang; Zhang, Guo; Wang, Zaizhao, E-mail: zzwang@nwsuaf.edu.cn

    2016-10-15

    Highlights: • Adult male G. rarus were exposed to 225 μg/L BPA for 7, 21 and 63 days. • BPA could induce spermatocyte apoptosis in rare minnow testis. • The mitochondrial apoptotic pathway participated in the germ cell apoptosis. • The spermatocyte apoptosis was likely initiated by BPA induced meiosis arrest. - Abstract: Bisphenol A (BPA) is an endocrine disruptor, and could induce germ cells apoptosis in the testis of mammals. But whether it could affect fish in the same mechanism has not’ been studied till now. In the present study, to investigate the influence of BPA on testis germ cells in fish, adult male rare minnow Gobiocypris rarus were exposed to 225 μg L{sup −1} (0.99 μM) BPA for 1, 3 and 9 weeks. Through TdT-mediated dUTP nick end labeling (TUNEL) and transmission electron microscope (TEM) analysis, we found that the amount of apoptotic spermatocytes significantly increased in a time dependent manner following BPA exposure. Western Blot results showed that the ratio of Bcl2/Bax, the important apoptosis regulators in intrinsic mitochondrial apoptotic pathway, was significantly decreased. qPCR showed that mRNA expression of several genes in mitochondrial apoptotic pathway including bcl2, bax, casp9, cytc and mcl1b were significantly changed following BPA exposure. In addition, mRNA expression of meiosis regulation genes (kpna7 and wee2), and genes involved in both apoptosis and meiosis (birc5, ccna1, and gsa1a) were also affected by BPA. Taken together, the present study demonstrated that BPA could induce spermatocytes apoptosis in rare minnow testis, and the apoptosis was probably under regulation of intrinsic mitochondrial apoptotic pathway. Moreover, the spermatocyte apoptosis was likely initiated by BPA induced meiosis arrest.

  9. X-linked inhibitor of apoptosis (XIAP) deficiency

    DEFF Research Database (Denmark)

    Speckmann, C.; Lehmberg, K.; Albert, M.H.

    2013-01-01

    X-linked inhibitor of apoptosis (XIAP) deficiency caused by mutations in BIRC4 was initially described in patients with X-linked lymphoproliferative syndrome (XLP) who had no mutations in SH2D1A. In the initial reports, EBV-associated hemophagocytic lymphohistiocytosis (HLH) was the predominant...

  10. Anisotropic conduction block and reentry in neonatal rat ventricular myocyte monolayers.

    Science.gov (United States)

    de Diego, Carlos; Chen, Fuhua; Xie, Yuanfang; Pai, Rakesh K; Slavin, Leonid; Parker, John; Lamp, Scott T; Qu, Zhilin; Weiss, James N; Valderrábano, Miguel

    2011-01-01

    Anisotropy can lead to unidirectional conduction block that initiates reentry. We analyzed the mechanisms in patterned anisotropic neonatal rat ventricular myocyte monolayers. Voltage and intracellular Ca (Ca(i)) were optically mapped under the following conditions: extrastimulus (S1S2) testing and/or tetrodotoxin (TTX) to suppress Na current availability; heptanol to reduce gap junction conductance; and incremental rapid pacing. In anisotropic monolayers paced at 2 Hz, conduction velocity (CV) was faster longitudinally than transversely, with an anisotropy ratio [AR = CV(L)/CV(T), where CV(L) and CV(T) are CV in the longitudinal and transverse directions, respectively], averaging 2.1 ± 0.8. Interventions decreasing Na current availability, such as S1S2 pacing and TTX, slowed CV(L) and CV(T) proportionately, without changing the AR. Conduction block preferentially occurred longitudinal to fiber direction, commonly initiating reentry. Interventions that decreased gap junction conductance, such as heptanol, decreased CV(T) more than CV(L), increasing the AR and causing preferential transverse conduction block and reentry. Rapid pacing resembled the latter, increasing the AR and promoting transverse conduction block and reentry, which was prevented by the Ca(i) chelator 1,2-bis oaminophenoxy ethane-N,N,N',N'-tetraacetic acid (BAPTA). In contrast to isotropic and uniformly anisotropic monolayers, in which reentrant rotors drifted and self-terminated, bidirectional anisotropy (i.e., an abrupt change in fiber direction exceeding 45°) caused reentry to anchor near the zone of fiber direction change in 77% of monolayers. In anisotropic monolayers, unidirectional conduction block initiating reentry can occur longitudinal or transverse to fiber direction, depending on whether the experimental intervention reduces Na current availability or decreases gap junction conductance, agreeing with theoretical predictions.

  11. Anisotropic resonant scattering from polymer photonic crystals.

    Science.gov (United States)

    Haines, Andrew I; Finlayson, Chris E; Snoswell, David R E; Spahn, Peter; Hellmann, G Peter; Baumberg, Jeremy J

    2012-11-20

    Hyperspectral goniometry reveals anisotropic scattering which dominates the visual appearance of self-assembled polymer opals. The technique allows reconstruction of the reciprocal-space of nanostructures, and indicates that chain defects formed during shear-ordering are responsible for the anisotropy in these samples. Enhanced scattering with improving order is shown to arise from increased effective refractive index contrast, while broadband background scatter is suppressed by absorptive dopants. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  12. An approach to anisotropic cosmologies. 6

    International Nuclear Information System (INIS)

    Raychaudhuri, A.K.

    1989-01-01

    In this paper the motivation for the study of anisotropic cosmological models is set out. Then the mathematical basis for the study of such models as well as the description of some of the exact solutions of this genre are given. Killing vectors that spell out spacetime symmetries, are defined and the Bianchi classification of spacetimes based on the structure of the Killing vectors described. After a consideration of the kinematics of matter flow some of the known solutions are presented and their properties described. (author)

  13. Anisotropic Density Estimation in Global Illumination

    DEFF Research Database (Denmark)

    Schjøth, Lars

    2009-01-01

    and bias in estimates. Good results are obtained by the use of anisotropic filtering. Two methods handles the most common cases; filtering illumination reflected from object surfaces. One methods extends filtering to the temporal domain and one performs filtering on illumination from participating media......Density estimation employed in multi-pass global illumination algorithms gives cause to a trade-off problem between bias and noise. The problem is seen most evident as blurring of strong illumination features. This thesis addresses the problem, presenting four methods that reduce both noise...

  14. Creating an anisotropic plasma resistivity with waves

    International Nuclear Information System (INIS)

    Fisch, N.J.; Boozer, A.H.

    1980-05-01

    An anisotropic plasma resistivity may be created by preferential heating of electrons traveling in one direction. This can result in a steady-state toroidal current in a tokamak even in the absence of net wave momentum. In fact, at high wave phase velocities, the current associated with the change in resistivity is greater than that associated with net momentum input. An immediate implication is that other waves, such as electron cyclotron waves, may be competitive with lower-hybrid waves as a means for generating current. An analytical expression is derived for the current generated per power dissipated which agrees remarkably well with numerical calculations

  15. Generalised model for anisotropic compact stars

    Energy Technology Data Exchange (ETDEWEB)

    Maurya, S.K. [University of Nizwa, Department of Mathematical and Physical Sciences College of Arts and Science, Nizwa (Oman); Gupta, Y.K. [Raj Kumar Goel Institute of Technology, Department of Mathematics, Ghaziabad, Uttar Pradesh (India); Ray, Saibal [Government College of Engineering and Ceramic Technology, Department of Physics, Kolkata, West Bengal (India); Deb, Debabrata [Indian Institute of Engineering Science and Technology, Shibpur, Department of Physics, Howrah, West Bengal (India)

    2016-12-15

    In the present investigation an exact generalised model for anisotropic compact stars of embedding class 1 is sought with a general relativistic background. The generic solutions are verified by exploring different physical aspects, viz. energy conditions, mass-radius relation, stability of the models, in connection to their validity. It is observed that the model presented here for compact stars is compatible with all these physical tests and thus physically acceptable as far as the compact star candidates RXJ 1856-37, SAX J 1808.4-3658 (SS1) and SAX J 1808.4-3658 (SS2) are concerned. (orig.)

  16. Effective Medium Theory for Anisotropic Metamaterials

    KAUST Repository

    Zhang, Xiujuan

    2017-11-12

    This dissertation includes the study of effective medium theories (EMTs) and their applications in describing wave propagation in anisotropic metamaterials, which can guide the design of metamaterials. An EMT based on field averaging is proposed to describe a peculiar anisotropic dispersion relation that is linear along the symmetry line but quadratic in the perpendicular direction. This dispersion relation is associated with the topological transition of the iso-frequency contours (IFCs), suggesting interesting wave propagation behaviors from beam shaping to beam splitting. In the framework of coherent potential approximation, an analytical EMT is further developed, with the ability to build a direct connection between the microscopic structure and the macroscopic material properties, which overcomes the requirement of prior knowledge of the field distributions. The derived EMT is valid beyond the long-wavelength limit. Using the EMT, an anisotropic zero-index metamaterial is designed. Moreover, the derived EMT imposes a condition that no scattered wave is generated in the ambient medium, which suggests the input signal cannot detect any object that might exist, making it invisible. Such correspondence between the EMT and the invisibilityinspires us to explore the wave cloaking in the same framework of coherent potential approximation. To further broaden the application realm of EMT, an EMT using the parameter retrieval method is studied in the regimes where the previously-developed EMTs are no longer accurate. Based on this study, in conjunction with the EMT mentioned above, a general scheme to realize coherent perfect absorption (CPA) in anisotropic metamaterials is proposed. As an exciting area in metamaterials, the field of metasurfaces has drawn great attention recently. As an easily attainable device, a grating may be the simplest version of metasurfaces. Here, an analytical EMT for gratings made of cylinders is developed by using the multiple scattering

  17. RELATIVISTIC CYCLOTRON INSTABILITY IN ANISOTROPIC PLASMAS

    Energy Technology Data Exchange (ETDEWEB)

    López, Rodrigo A.; Moya, Pablo S.; Muñoz, Víctor; Valdivia, J. Alejandro [Departamento de Física, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago (Chile); Navarro, Roberto E.; Araneda, Jaime A. [Departamento de Física, Facultad de Ciencias Físicas y Matemáticas, Universidad de Concepción, Casilla 160-C, Concepción (Chile); Viñas, Adolfo F., E-mail: rlopez186@gmail.com [NASA Goddard Space Flight Center, Heliophysics Science Division, Geospace Physics Laboratory, Mail Code 673, Greenbelt, MD 20771 (United States)

    2016-11-20

    A sufficiently large temperature anisotropy can sometimes drive various types of electromagnetic plasma micro-instabilities, which can play an important role in the dynamics of relativistic pair plasmas in space, astrophysics, and laboratory environments. Here, we provide a detailed description of the cyclotron instability of parallel propagating electromagnetic waves in relativistic pair plasmas on the basis of a relativistic anisotropic distribution function. Using plasma kinetic theory and particle-in-cell simulations, we study the influence of the relativistic temperature and the temperature anisotropy on the collective and noncollective modes of these plasmas. Growth rates and dispersion curves from the linear theory show a good agreement with simulations results.

  18. Analysis of anisotropic shells containing flowing fluid

    International Nuclear Information System (INIS)

    Lakis, A.A.

    1983-01-01

    A general theory for the dynamic analysis of anisotropic thin cylindrical shells containing flowing fluid is presented. The shell may be uniform or non-uniform, provided it is geometrically axially symmetric. This is a finite- element theory, using cylindrical finite elements, but the displacement functions are determined by using classical shell theory. A new solution of the wave equation of the liquid finite element leads to an expression of the fluid pressure, p, as a function of the nodal displacements of the element and three operative forces (inertia, centrifugal and Coriolis) of the moving fluid. (Author) [pt

  19. Anisotropic elliptic PDEs for feature classification.

    Science.gov (United States)

    Wang, Shengfa; Hou, Tingbo; Li, Shuai; Su, Zhixun; Qin, Hong

    2013-10-01

    The extraction and classification of multitype (point, curve, patch) features on manifolds are extremely challenging, due to the lack of rigorous definition for diverse feature forms. This paper seeks a novel solution of multitype features in a mathematically rigorous way and proposes an efficient method for feature classification on manifolds. We tackle this challenge by exploring a quasi-harmonic field (QHF) generated by elliptic PDEs, which is the stable state of heat diffusion governed by anisotropic diffusion tensor. Diffusion tensor locally encodes shape geometry and controls velocity and direction of the diffusion process. The global QHF weaves points into smooth regions separated by ridges and has superior performance in combating noise/holes. Our method's originality is highlighted by the integration of locally defined diffusion tensor and globally defined elliptic PDEs in an anisotropic manner. At the computational front, the heat diffusion PDE becomes a linear system with Dirichlet condition at heat sources (called seeds). Our new algorithms afford automatic seed selection, enhanced by a fast update procedure in a high-dimensional space. By employing diffusion probability, our method can handle both manufactured parts and organic objects. Various experiments demonstrate the flexibility and high performance of our method.

  20. Lyotropic Liquid Crystal Phases from Anisotropic Nanomaterials.

    Science.gov (United States)

    Dierking, Ingo; Al-Zangana, Shakhawan

    2017-10-01

    Liquid crystals are an integral part of a mature display technology, also establishing themselves in other applications, such as spatial light modulators, telecommunication technology, photonics, or sensors, just to name a few of the non-display applications. In recent years, there has been an increasing trend to add various nanomaterials to liquid crystals, which is motivated by several aspects of materials development. (i) addition of nanomaterials can change and thus tune the properties of the liquid crystal; (ii) novel functionalities can be added to the liquid crystal; and (iii) the self-organization of the liquid crystalline state can be exploited to template ordered structures or to transfer order onto dispersed nanomaterials. Much of the research effort has been concentrated on thermotropic systems, which change order as a function of temperature. Here we review the other side of the medal, the formation and properties of ordered, anisotropic fluid phases, liquid crystals, by addition of shape-anisotropic nanomaterials to isotropic liquids. Several classes of materials will be discussed, inorganic and mineral liquid crystals, viruses, nanotubes and nanorods, as well as graphene oxide.

  1. The Effective Coherence Length in Anisotropic Superconductors

    International Nuclear Information System (INIS)

    Polturak, E.; Koren, G.; Nesher, O

    1999-01-01

    If electrons are transmitted from a normal conductor(N) into a superconductor(S), common wisdom has it that the electrons are converted into Cooper pairs within a coherence length from the interface. This is true in conventional superconductors with an isotropic order parameter. We have established experimentally that the situation is rather different in high Tc superconductors having an anisotropic order parameter. We used epitaxial thin film S/N bilayers having different interface orientations in order to inject carriers from S into N along different directions. The distance to which these carriers penetrate were determined through their effect on the Tc of the bilayers. We found that the effective coherence length is 20A only along the a or b directions, while in other directions we find a length of 250dr20A out of plane, and an even larger value for in-plane, off high symmetry directions. These observations can be explained using the Blonder-Tinkham-Klapwijk model adapted to anisotropic superconductivity. Several implications of our results on outstanding problems with high Tc junctions will be discussed

  2. Finite-difference schemes for anisotropic diffusion

    Energy Technology Data Exchange (ETDEWEB)

    Es, Bram van, E-mail: es@cwi.nl [Centrum Wiskunde and Informatica, P.O. Box 94079, 1090GB Amsterdam (Netherlands); FOM Institute DIFFER, Dutch Institute for Fundamental Energy Research, Association EURATOM-FOM (Netherlands); Koren, Barry [Eindhoven University of Technology (Netherlands); Blank, Hugo J. de [FOM Institute DIFFER, Dutch Institute for Fundamental Energy Research, Association EURATOM-FOM (Netherlands)

    2014-09-01

    In fusion plasmas diffusion tensors are extremely anisotropic due to the high temperature and large magnetic field strength. This causes diffusion, heat conduction, and viscous momentum loss, to effectively be aligned with the magnetic field lines. This alignment leads to different values for the respective diffusive coefficients in the magnetic field direction and in the perpendicular direction, to the extent that heat diffusion coefficients can be up to 10{sup 12} times larger in the parallel direction than in the perpendicular direction. This anisotropy puts stringent requirements on the numerical methods used to approximate the MHD-equations since any misalignment of the grid may cause the perpendicular diffusion to be polluted by the numerical error in approximating the parallel diffusion. Currently the common approach is to apply magnetic field-aligned coordinates, an approach that automatically takes care of the directionality of the diffusive coefficients. This approach runs into problems at x-points and at points where there is magnetic re-connection, since this causes local non-alignment. It is therefore useful to consider numerical schemes that are tolerant to the misalignment of the grid with the magnetic field lines, both to improve existing methods and to help open the possibility of applying regular non-aligned grids. To investigate this, in this paper several discretization schemes are developed and applied to the anisotropic heat diffusion equation on a non-aligned grid.

  3. Lyotropic Liquid Crystal Phases from Anisotropic Nanomaterials

    Directory of Open Access Journals (Sweden)

    Ingo Dierking

    2017-10-01

    Full Text Available Liquid crystals are an integral part of a mature display technology, also establishing themselves in other applications, such as spatial light modulators, telecommunication technology, photonics, or sensors, just to name a few of the non-display applications. In recent years, there has been an increasing trend to add various nanomaterials to liquid crystals, which is motivated by several aspects of materials development. (i addition of nanomaterials can change and thus tune the properties of the liquid crystal; (ii novel functionalities can be added to the liquid crystal; and (iii the self-organization of the liquid crystalline state can be exploited to template ordered structures or to transfer order onto dispersed nanomaterials. Much of the research effort has been concentrated on thermotropic systems, which change order as a function of temperature. Here we review the other side of the medal, the formation and properties of ordered, anisotropic fluid phases, liquid crystals, by addition of shape-anisotropic nanomaterials to isotropic liquids. Several classes of materials will be discussed, inorganic and mineral liquid crystals, viruses, nanotubes and nanorods, as well as graphene oxide.

  4. Lyotropic Liquid Crystal Phases from Anisotropic Nanomaterials

    Science.gov (United States)

    Dierking, Ingo

    2017-01-01

    Liquid crystals are an integral part of a mature display technology, also establishing themselves in other applications, such as spatial light modulators, telecommunication technology, photonics, or sensors, just to name a few of the non-display applications. In recent years, there has been an increasing trend to add various nanomaterials to liquid crystals, which is motivated by several aspects of materials development. (i) addition of nanomaterials can change and thus tune the properties of the liquid crystal; (ii) novel functionalities can be added to the liquid crystal; and (iii) the self-organization of the liquid crystalline state can be exploited to template ordered structures or to transfer order onto dispersed nanomaterials. Much of the research effort has been concentrated on thermotropic systems, which change order as a function of temperature. Here we review the other side of the medal, the formation and properties of ordered, anisotropic fluid phases, liquid crystals, by addition of shape-anisotropic nanomaterials to isotropic liquids. Several classes of materials will be discussed, inorganic and mineral liquid crystals, viruses, nanotubes and nanorods, as well as graphene oxide. PMID:28974025

  5. Elastic Modes of an Anisotropic Ridge Waveguide

    Directory of Open Access Journals (Sweden)

    Ameya Galinde

    2012-01-01

    Full Text Available A semi-analytical method for finding the elastic modes propagating along the edge of an anisotropic semi-infinite plate is presented. Solutions are constructed as linear combinations of a finite number of the corresponding infinite plate modes with the constraint that they decay in the direction perpendicular to the edge and collectively satisfy the free boundary condition over the edge surface. Such modes that are confined to the edge can be used to approximate solutions of acoustic ridge waveguides whose supporting structures are sufficiently far away from the free edge. The semi-infinite plate or ridge is allowed to be oriented arbitrarily in the anisotropic crystal. Modifications to the theory to find symmetric and antisymmetric solutions for special crystal orientations are also presented. Accuracy of the solutions can be improved by including more plate modes in the series. Numerical techniques to find modal dispersion relations and orientation dependent modal behavior, are discussed. Results for ridges etched in single crystal Silicon are found to be in good agreement with Finite Element simulations. It is found that variations in modal phase velocity with respect to crystal orientation are not significant, suggesting that anisotropy may not be a critical issue while designing ridge waveguides in Silicon.

  6. Electrically Anisotropic Layered Perovskite Single Crystal

    KAUST Repository

    Li, Ting-You

    2016-04-01

    Organic-inorganic hybrid perovskites (OIHPs), which are promising materials for electronic and optoelectronic applications (1-10), have made into layered organic-inorganic hybrid perovskites (LOIHPs). These LOIHPs have been applied to thin-film transistors, solar cells and tunable wavelength phosphors (11-18). It is known that devices fabricated with single crystal exhibit the superior performance, which makes the growth of large-sized single crystals critical for future device applications (19-23). However, the difficulty in growing large-sized LOIHPs single crystal with superior electrical properties limits their practical applications. Here, we report a method to grow the centimeter-scaled LOIHP single crystal of [(HOC2H4NH3)2PbI4], demonstrating the potentials in mass production. After that, we reveal anisotropic electrical and optoelectronic properties which proved the carrier propagating along inorganic framework. The carrier mobility of in-inorganic-plane (in-plane) devices shows the average value of 45 cm2 V–1 s–1 which is about 100 times greater than the record of LOIHP devices (15), showing the importance of single crystal in device application. Moreover, the LOIHP single crystals show its ultra-short carrier lifetime of 42.7 ps and photoluminescence quantum efficiency (PLQE) of 25.4 %. We expect this report to be a start of LOIHPs for advanced applications in which the anisotropic properties are needed (24-25), and meets the demand of high-speed applications and fast-response applications.

  7. Relativistic model for anisotropic strange stars

    Science.gov (United States)

    Deb, Debabrata; Chowdhury, Sourav Roy; Ray, Saibal; Rahaman, Farook; Guha, B. K.

    2017-12-01

    In this article, we attempt to find a singularity free solution of Einstein's field equations for compact stellar objects, precisely strange (quark) stars, considering Schwarzschild metric as the exterior spacetime. To this end, we consider that the stellar object is spherically symmetric, static and anisotropic in nature and follows the density profile given by Mak and Harko (2002) , which satisfies all the physical conditions. To investigate different properties of the ultra-dense strange stars we have employed the MIT bag model for the quark matter. Our investigation displays an interesting feature that the anisotropy of compact stars increases with the radial coordinate and attains its maximum value at the surface which seems an inherent property for the singularity free anisotropic compact stellar objects. In this connection we also perform several tests for physical features of the proposed model and show that these are reasonably acceptable within certain range. Further, we find that the model is consistent with the energy conditions and the compact stellar structure is stable with the validity of the TOV equation and Herrera cracking concept. For the masses below the maximum mass point in mass vs radius curve the typical behavior achieved within the framework of general relativity. We have calculated the maximum mass and radius of the strange stars for the three finite values of bag constant Bg.

  8. Building an Anisotropic Meniscus with Zonal Variations

    Science.gov (United States)

    Higashioka, Michael M.; Chen, Justin A.; Hu, Jerry C.

    2014-01-01

    Toward addressing the difficult problems of knee meniscus regeneration, a self-assembling process has been used to re-create the native morphology and matrix properties. A significant problem in such attempts is the recapitulation of the distinct zones of the meniscus, the inner, more cartilaginous and the outer, more fibrocartilaginous zones. In this study, an anisotropic and zonally variant meniscus was produced by self-assembly of the inner meniscus (100% chondrocytes) followed by cell seeding the outer meniscus (coculture of chondrocytes and meniscus cells). After 4 weeks in culture, the engineered, inner meniscus exhibited a 42% increase in both instantaneous and relaxation moduli and a 62% increase in GAG/DW, as compared to the outer meniscus. In contrast, the circumferential tensile modulus and collagen/DW of the outer zone was 101% and 129% higher, respectively, than the values measured for the inner zone. Furthermore, there was no difference in the radial tensile modulus between the control and zonal engineered menisci, suggesting that the inner and outer zones of the engineered zonal menisci successfully integrated. These data demonstrate that not only can biomechanical and biochemical properties be engineered to differ by the zone, but they can also recapitulate the anisotropic behavior of the knee meniscus. PMID:23931258

  9. (3 +1 )D Quasiparticle Anisotropic Hydrodynamics for Ultrarelativistic Heavy-Ion Collisions

    Science.gov (United States)

    Alqahtani, Mubarak; Nopoush, Mohammad; Ryblewski, Radoslaw; Strickland, Michael

    2017-07-01

    We present the first comparisons of experimental data with phenomenological results from (3 +1 )D quasiparticle anisotropic hydrodynamics (aHydroQP). We compare particle spectra, average transverse momentum, and elliptic flow. The dynamical equations used for the hydrodynamic stage utilize aHydroQP, which naturally includes both shear and bulk viscous effects. The (3 +1 )D aHydroQP evolution obtained is self-consistently converted to hadrons using anisotropic Cooper-Frye freeze-out. Hadron production and decays are modeled using a customized version of therminator 2. In this first study, we utilized smooth Glauber-type initial conditions and a single effective freeze-out temperature TFO=130 MeV with all hadronic species in full chemical equilibrium. With this rather simple setup, we find a very good description of many heavy-ion observables.

  10. 3D constitutive model of anisotropic damage for unidirectional ply based on physical failure mechanisms

    DEFF Research Database (Denmark)

    Qing, Hai; Mishnaevsky, Leon

    2010-01-01

    A 3D anisotropic continuum damage model is developed for the computational analysis of the elastic–brittle behaviour of fibre-reinforced composite. The damage model is based on a set of phenomenological failure criteria for fibre-reinforced composite, which can distinguish the matrix and fibre...... failure under tensile and compressive loading. The homogenized continuum theory is adopted for the anisotropic elastic damage constitutive model. The damage modes occurring in the longitudinal and transverse directions of a ply are represented by a damage vector. The elastic damage model is implemented...... in a computational finite element framework, which is capable of predicting initial failure, subsequent progressive damage up to final collapse. Crack band model and viscous regularization are applied to depress the convergence difficulties associated with strain softening behaviours. To verify the accuracy...

  11. (3+1)D Quasiparticle Anisotropic Hydrodynamics for Ultrarelativistic Heavy-Ion Collisions.

    Science.gov (United States)

    Alqahtani, Mubarak; Nopoush, Mohammad; Ryblewski, Radoslaw; Strickland, Michael

    2017-07-28

    We present the first comparisons of experimental data with phenomenological results from (3+1)D quasiparticle anisotropic hydrodynamics (aHydroQP). We compare particle spectra, average transverse momentum, and elliptic flow. The dynamical equations used for the hydrodynamic stage utilize aHydroQP, which naturally includes both shear and bulk viscous effects. The (3+1)D aHydroQP evolution obtained is self-consistently converted to hadrons using anisotropic Cooper-Frye freeze-out. Hadron production and decays are modeled using a customized version of therminator 2. In this first study, we utilized smooth Glauber-type initial conditions and a single effective freeze-out temperature T_{FO}=130  MeV with all hadronic species in full chemical equilibrium. With this rather simple setup, we find a very good description of many heavy-ion observables.

  12. Anisotropic cosmological models and generalized scalar tensor theory

    Indian Academy of Sciences (India)

    physics pp. 669–673. Anisotropic cosmological models and generalized scalar tensor theory. SUBENOY CHAKRABORTY1,*, BATUL CHANDRA SANTRA2 and ... Anisotropic cosmological models; general scalar tensor theory; inflation. PACS Nos 98.80.Hw; 04.50.+h; 98.80.Cq. 1. Introduction. Brans–Dicke theory [1] (BD ...

  13. Anisotropic static solutions in modelling highly compact bodies

    Indian Academy of Sciences (India)

    Einstein field equations for static anisotropic spheres are solved and exact interior solutions obtained. This paper extends earlier treatments to include anisotropic models which accommodate a wider variety of physically viable energy densities. Two classes of solutions are possible. The first class contains the limiting case ...

  14. Orthonormal bases for anisotropic α-modulation spaces

    DEFF Research Database (Denmark)

    Rasmussen, Kenneth Niemann

    In this article we construct orthonormal bases for bi-variate anisotropic α-modulation spaces. The construction is based on generating a nice anisotropic α-covering and using carefully selected tensor products of univariate brushlet functions with regards to this covering. As an application, we s...

  15. Wave propagation in a general anisotropic poroelastic medium ...

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Earth System Science; Volume 116; Issue 4. Wave propagation in a general anisotropic poroelastic medium: Biot's theories and homogenisation theory. M D Sharma. Volume 116 Issue 4 August ... Keywords. Anisotropic poroelastic (APE) solid; Biot's theory; homogenisation theory; phase velocity.

  16. Modeling and Measurements of CMUTs with Square Anisotropic Plates

    DEFF Research Database (Denmark)

    la Cour, Mette Funding; Christiansen, Thomas Lehrmann; Dahl-Petersen, Christian

    2013-01-01

    The conventional method of modeling CMUTs use the isotropic plate equation to calculate the deflection, leading to deviations from FEM simulations including anisotropic effects of around 10% in center deflection. In this paper, the deflection is found for square plates using the full anisotropic ...

  17. Existence of longitudinal waves in pre-stressed anisotropic elastic ...

    Indian Academy of Sciences (India)

    In a pre-stressed anisotropic elastic medium, three types of quasi-waves propagate along an arbi- trary direction. In general, none of the waves is truly longitudinal. The present study finds the specific directions in a pre-stressed anisotropic elastic medium along which longitudinal waves may propagate. This paper ...

  18. On the origins of the anisotropic mechanical behaviour of extruded ...

    Indian Academy of Sciences (India)

    This paper presents some experimental investigations about the origins of the anisotropic behaviour in cyclic loadings of ... In the second step, microstructural investigations were performed in order to understand the origins of the anisotropic ..... [20] Djebli A, Aid A, Bendouba M, Amrouche A, Benguediab M and Benseddiq ...

  19. Orthonormal bases for anisotropic α-modulation spaces

    DEFF Research Database (Denmark)

    Rasmussen, Kenneth Niemann

    2012-01-01

    In this article we construct orthonormal bases for bi-variate anisotropic α-modulation spaces. The construction is based on generating a nice anisotropic α-covering and using carefully selected tensor products of univariate brushlet functions with regards to this covering. As an application, we s...

  20. Phenomenological aspects of an anisotropic quark-gluon plasma

    Energy Technology Data Exchange (ETDEWEB)

    Martinez Guerrero, Mauricio

    2010-04-30

    In this work we investigate phenomenological aspects of an anisotropic quark-gluon plasma. In the first part of this thesis, we formulate phenomenologicalmodels that take into account the momentumspace anisotropy of the system developed during the expansion of the fireball at early-times. By including the proper-time dependence of the parton hard momentum scale, p{sub hard}({tau}), and the plasma anisotropy parameter, {xi}({tau}), the proposed models allow us to interpolate from 0+1 pre-equilibrated expansion at early-times to 0+1 ideal hydrodynamics at late times. We study dilepton production as a valuable observable to experimentally determine the isotropization time of the system as well as the degree of anisotropy developed at early-times. We generalize our interpolating models to include the rapidity dependence of p{sub hard} and consider its impact on forward dileptons. Next, we discuss how to constrain the onset of hydrodynamics by demanding two requirements of the solutions to the equations of motion of viscous hydrodynamics. We show this explicitly for 0+1 dimensional 2nd-order conformal viscous hydrodynamics and find that the initial conditions are non-trivially constrained. Finally, we demonstrate how to match the initial conditions for 0+1 dimensional viscous hydrodynamics from pre-equilibrated expansion. We analyze the dependence of the entropy production on the pre-equilibrium phase and discuss limitations of the standard definitions of the non-equilibrium entropy in kinetic theory. (orig.)

  1. Phenomenological aspects of an anisotropic quark-gluon plasma

    International Nuclear Information System (INIS)

    Martinez Guerrero, Mauricio

    2010-01-01

    In this work we investigate phenomenological aspects of an anisotropic quark-gluon plasma. In the first part of this thesis, we formulate phenomenologicalmodels that take into account the momentumspace anisotropy of the system developed during the expansion of the fireball at early-times. By including the proper-time dependence of the parton hard momentum scale, p hard (τ), and the plasma anisotropy parameter, ξ(τ), the proposed models allow us to interpolate from 0+1 pre-equilibrated expansion at early-times to 0+1 ideal hydrodynamics at late times. We study dilepton production as a valuable observable to experimentally determine the isotropization time of the system as well as the degree of anisotropy developed at early-times. We generalize our interpolating models to include the rapidity dependence of p hard and consider its impact on forward dileptons. Next, we discuss how to constrain the onset of hydrodynamics by demanding two requirements of the solutions to the equations of motion of viscous hydrodynamics. We show this explicitly for 0+1 dimensional 2nd-order conformal viscous hydrodynamics and find that the initial conditions are non-trivially constrained. Finally, we demonstrate how to match the initial conditions for 0+1 dimensional viscous hydrodynamics from pre-equilibrated expansion. We analyze the dependence of the entropy production on the pre-equilibrium phase and discuss limitations of the standard definitions of the non-equilibrium entropy in kinetic theory. (orig.)

  2. Critical frontier of anisotropic planar Potts ferromagnets : a new conjucture

    International Nuclear Information System (INIS)

    Tsallis, C.

    1982-01-01

    The critical frontier of the nearest-neighbour q-state Potts ferromagnet in the fully anisotropic 3-12 lattice is conjectured through a star-triangle transformation. It recovers all the available exact results concerning particular cases, namely: (i) anisotropic square lattice for all q; (ii) anisotropic triangular and honeycomb lattices for all q; (iii) anisotropic Kagome and diced lattices for q=2; (iv) isotropic 3-12 and Asanoha lattices for q=2. It provides proposals for several other planar lattices, in particular for the anisotropic Kagome (and diced) one for q different 2, where it slightly differs from the Wu 1979 conjecture (Which also satisfies the cases (i) and (iii)). The bond percolation critical probabilities on the 3-12 and Kagome lattices are determined to be respectively p sub(c) = 0.739830... and p sub(c) = 0.522372.... (Author) [pt

  3. Role of the nucleus in apoptosis: signaling and execution.

    Science.gov (United States)

    Prokhorova, Evgeniia A; Zamaraev, Alexey V; Kopeina, Gelina S; Zhivotovsky, Boris; Lavrik, Inna N

    2015-12-01

    Since their establishment in the early 1970s, the nuclear changes upon apoptosis induction, such as the condensation of chromatin, disassembly of nuclear scaffold proteins and degradation of DNA, were, and still are, considered as the essential steps and hallmarks of apoptosis. These are the characteristics of the execution phase of apoptotic cell death. In addition, accumulating data clearly show that some nuclear events can lead to the induction of apoptosis. In particular, if DNA lesions resulting from deregulation during the cell cycle or DNA damage induced by chemotherapeutic drugs or viral infection cannot be efficiently eliminated, apoptotic mechanisms, which enable cellular transformation to be avoided, are activated in the nucleus. The functional heterogeneity of the nuclear organization allows the tight regulation of these signaling events that involve the movement of various nuclear proteins to other intracellular compartments (and vice versa) to initiate and govern apoptosis. Here, we discuss how these events are coordinated to execute apoptotic cell death.

  4. Apoptosis and DNA Methylation

    International Nuclear Information System (INIS)

    Meng, Huan X.; Hackett, James A.; Nestor, Colm; Dunican, Donncha S.; Madej, Monika; Reddington, James P.; Pennings, Sari; Harrison, David J.; Meehan, Richard R.

    2011-01-01

    Epigenetic mechanisms assist in maintaining gene expression patterns and cellular properties in developing and adult tissues. The molecular pathology of disease states frequently includes perturbation of DNA and histone methylation patterns, which can activate apoptotic pathways associated with maintenance of genome integrity. This perspective focuses on the pathways linking DNA methyltransferases and methyl-CpG binding proteins to apoptosis, and includes new bioinformatic analyses to characterize the evolutionary origin of two G/T mismatch-specific thymine DNA glycosylases, MBD4 and TDG

  5. Apoptosis in HEp-2 cells infected with Ureaplasma diversum

    Directory of Open Access Journals (Sweden)

    Aline Teixeira Amorim

    2014-01-01

    Full Text Available BACKGROUND: Bacterial pathogens have many strategies for infecting and persisting in host cells. Adhesion, invasion and intracellular life are important features in the biology of mollicutes. The intracellular location ofUreaplasma diversum may trigger disturbances in the host cell. This includes activation or inhibition of pro and anti-apoptotic factors, which facilitate the development of host damage. The aim of the present study was to associate U. diversum infection in HEp-2 cells and apoptosis induction. Cells were infected for 72hs with four U. diversum clinical isolates and an ATCC strain. The U. diversuminvasion was analyzed by Confocal Laser Scanning Microscopy and gentamicin invasion assay. The apoptosis was evaluated using pro-apoptotic and anti-apoptotic gene expression, and FITC Annexin V/Dead Cell Apoptosis Kit. RESULTS: The number of internalized ureaplasma in HEp-2 cells increased significantly throughout the infection. The flow cytometry analysis with fluorochromes to detect membrane depolarization and gene expression for caspase 2, 3 and 9 increased in infected cells after 24 hours. However, after 72 hours a considerable decrease of apoptotic cells was observed. CONCLUSIONS: The data suggests that apoptosis may be initially induced by some isolates in association with HEp-2 cells, but over time, there was no evidence of apoptosis in the presence of ureaplasma and HEp-2 cells. The initial increase and then decrease in apoptosis could be related to bacterial pathogen-associated molecular pattern (PAMPS. Moreover, the isolates of U. diversum presented differences in the studied parameters for apoptosis. It was also observed that the amount of microorganisms was not proportional to the induction of apoptosis in HEp-2 cells.

  6. Apoptosis in HEp-2 cells infected with Ureaplasma diversum.

    Science.gov (United States)

    Amorim, Aline Teixeira; Marques, Lucas Miranda; Santos, Angelita Maria Oliveira Gusmão; Martins, Hellen Braga; Barbosa, Maysa Santos; Rezende, Izadora Souza; Andrade, Ewerton Ferraz; Campos, Guilherme Barreto; Lobão, Tássia Neves; Cortez, Beatriz Araujo; Monezi, Telma Alvez; Machado-Santelli, Glaucia Maria; Timenetsky, Jorge

    2014-09-04

    Bacterial pathogens have many strategies for infecting and persisting in host cells. Adhesion, invasion and intracellular life are important features in the biology of mollicutes. The intracellular location of Ureaplasma diversum may trigger disturbances in the host cell. This includes activation or inhibition of pro and anti-apoptotic factors, which facilitate the development of host damage. The aim of the present study was to associate U. diversum infection in HEp-2 cells and apoptosis induction. Cells were infected for 72hs with four U. diversum clinical isolates and an ATCC strain. The U. diversum invasion was analyzed by Confocal Laser Scanning Microscopy and gentamicin invasion assay. The apoptosis was evaluated using pro-apoptotic and anti-apoptotic gene expression, and FITC Annexin V/Dead Cell Apoptosis Kit. The number of internalized ureaplasma in HEp-2 cells increased significantly throughout the infection. The flow cytometry analysis with fluorochromes to detect membrane depolarization and gene expression for caspase 2, 3 and 9 increased in infected cells after 24 hours. However, after 72 hours a considerable decrease of apoptotic cells was observed. The data suggests that apoptosis may be initially induced by some isolates in association with HEp-2 cells, but over time, there was no evidence of apoptosis in the presence of ureaplasma and HEp-2 cells. The initial increase and then decrease in apoptosis could be related to bacterial pathogen-associated molecular pattern (PAMPS). Moreover, the isolates of U. diversum presented differences in the studied parameters for apoptosis. It was also observed that the amount of microorganisms was not proportional to the induction of apoptosis in HEp-2 cells.

  7. Anisotropic phenomena in gauge/gravity duality

    International Nuclear Information System (INIS)

    Zeller, Hansjoerg

    2014-01-01

    In this thesis we use gauge/gravity duality to model anisotropic effects realised in nature. Firstly we analyse transport properties in holographic systems with a broken rotational invariance. Secondly we discuss geometries dual to IR fixed points with anisotropic scaling behaviour, which are related to quantum critical points in condensed matter systems. Gauge/gravity duality relates a gravity theory in Anti-de Sitter space to a lower dimensional strongly coupled quantum field theory in Minkowski space. Over the past decade this duality provided many insights into systems at strong coupling, e.g. quark-gluon plasma and condensed matter close to quantum critical points. One very important result computed in this framework is the value of the shear viscosity divided by the entropy density in strongly coupled theories. The quantitative result agrees very well with measurements of the ratio in quark-gluon plasma. However, for isotropic two derivative Einstein gravity it is temperature independent. We show that by breaking the rotational symmetry of a system we obtain a temperature dependent shear viscosity over entropy density. This is important to make contact with real world systems, since substances in nature display such dependence. In addition, we derive various transport properties in strongly coupled anisotropic systems using the gauge/gravity dictionary. The most notable results include an electrical conductivity with Drude behaviour in the low frequency region. This resembles conductors with broken translational invariance. However, we did not implement the breaking explicitly. Furthermore, our analysis shows that this setup models effects, resembling the piezoelectric and exoelectric effects, known from liquid crystals. In a second project we discuss a geometry with non-trivial scaling behaviour in order to model an IR fixed point of condensed matter theories. We construct the UV completion of this geometry and analyse its properties by computing the

  8. Reassessing apoptosis in plants.

    Science.gov (United States)

    Dickman, Martin; Williams, Brett; Li, Yurong; de Figueiredo, Paul; Wolpert, Thomas

    2017-10-01

    Cell death can be driven by a genetically programmed signalling pathway known as programmed cell death (PCD). In plants, PCD occurs during development as well as in response to environmental and biotic stimuli. Our understanding of PCD regulation in plants has advanced significantly over the past two decades; however, the molecular machinery responsible for driving the system remains elusive. Thus, whether conserved PCD regulatory mechanisms include plant apoptosis remains enigmatic. Animal apoptotic regulators, including Bcl-2 family members, have not been identified in plants but expression of such regulators can trigger or suppress plant PCD. Moreover, plants exhibit nearly all of the biochemical and morphological features of apoptosis. One difference between plant and animal PCD is the absence of phagocytosis in plants. Evidence is emerging that the vacuole may be key to removal of unwanted plant cells, and may carry out functions that are analogous to animal phagocytosis. Here, we provide context for the argument that apoptotic-like cell death occurs in plants.

  9. Experimental evidence for anisotropic double exchange interaction driven anisotropic transport in manganite heterostructures

    NARCIS (Netherlands)

    Liao, Zhaoliang; Koster, Gertjan; Huijben, Mark; Rijnders, A.J.H.M.

    2017-01-01

    An anisotropic double exchange interaction driven giant transport anisotropy is demonstrated in a canonic double exchange system of La2/3Sr1/3MnO3 ultrathin films epitaxially grown on NdGaO3 (110) substrates. The oxygen octahedral coupling at the La2/3Sr1/3MnO3/NdGaO3 interface induces a planar

  10. Anisotropic plasmas from axion and dilaton deformations

    Energy Technology Data Exchange (ETDEWEB)

    Donos, Aristomenis [Centre for Particle Theory and Department of Mathematical Sciences, Durham University,South Rd., Durham (United Kingdom); Gauntlett, Jerome P. [Blackett Laboratory, Imperial College,Prince Consort Rd., London (United Kingdom); Sosa-Rodriguez, Omar [Centre for Particle Theory and Department of Mathematical Sciences, Durham University,South Rd., Durham (United Kingdom)

    2016-11-02

    We construct black hole solutions of type IIB supergravity that are holographically dual to anisotropic plasmas arising from deformations of an infinite class of four-dimensional CFTs. The CFTs are dual to AdS{sub 5}×X{sub 5}, where X{sub 5} is an Einstein manifold, and the deformations involve the type IIB axion and dilaton, with non-trivial periodic dependence on one of the spatial directions of the CFT. At low temperatures the solutions approach smooth domain wall solutions with the same AdS{sub 5}×X{sub 5} solution appearing in the far IR. For sufficiently large deformations an intermediate scaling regime appears which is governed by a Lifshitz-like scaling solution. We calculate the DC thermal conductivity and some components of the shear viscosity tensor.

  11. Analytical study of anisotropic compact star models

    Science.gov (United States)

    Ivanov, B. V.

    2017-11-01

    A simple classification is given of the anisotropic relativistic star models, resembling the one of charged isotropic solutions. On the ground of this database, and taking into account the conditions for physically realistic star models, a method is proposed for generating all such solutions. It is based on the energy density and the radial pressure as seeding functions. Numerous relations between the realistic conditions are found and the need for a graphic proof is reduced just to one pair of inequalities. This general formalism is illustrated with an example of a class of solutions with linear equation of state and simple energy density. It is found that the solutions depend on three free constants and concrete examples are given. Some other popular models are studied with the same method.

  12. Analytical study of anisotropic compact star models

    Energy Technology Data Exchange (ETDEWEB)

    Ivanov, B.V. [Bulgarian Academy of Science, Institute for Nuclear Research and Nuclear Energy, Sofia (Bulgaria)

    2017-11-15

    A simple classification is given of the anisotropic relativistic star models, resembling the one of charged isotropic solutions. On the ground of this database, and taking into account the conditions for physically realistic star models, a method is proposed for generating all such solutions. It is based on the energy density and the radial pressure as seeding functions. Numerous relations between the realistic conditions are found and the need for a graphic proof is reduced just to one pair of inequalities. This general formalism is illustrated with an example of a class of solutions with linear equation of state and simple energy density. It is found that the solutions depend on three free constants and concrete examples are given. Some other popular models are studied with the same method. (orig.)

  13. Fluid flow through anisotropic porous medium

    International Nuclear Information System (INIS)

    Telles, A.S.; Massarani, G.

    1975-01-01

    Darcy's equation represents a simplified form of the equation of motion for the fluid flowing through a porous medium. The simplifications concern the elimination of the acceleration, the divergence of the extra stress terms, and the assumption of existence of a linear form in the velocity for the resistive force the fluid exerts upon the solid. This hypothesis may not be valid for all anisotropic media. In some instances, measurements of directional resistivity suggest existence of the resistivity tensor, leaving entirely open the question of symmetry. In connection with this important question, an experimental scheme for the determination of the antisymmetric part of this tensor is suggested. The conclusion is that material symmetries is the only macroscopic concept that imposes restrictions on the form of the resistivity and extra stress tensors [pt

  14. Long-range interaction of anisotropic systems

    KAUST Repository

    Zhang, Junyi

    2015-02-01

    The first-order electrostatic interaction energy between two far-apart anisotropic atoms depends not only on the distance between them but also on their relative orientation, according to Rayleigh-Schrödinger perturbation theory. Using the first-order interaction energy and the continuum model, we study the long-range interaction between a pair of parallel pristine graphene sheets at zero temperature. The asymptotic form of the obtained potential density, &epsi:(D) &prop: ?D ?3 ?O(D?4), is consistent with the random phase approximation and Lifshitz theory. Accordingly, neglectance of the anisotropy, especially the nonzero first-order interaction energy, is the reason why the widely used Lennard-Jones potential approach and dispersion corrections in density functional theory give a wrong asymptotic form ε(D) &prop: ?D?4. © EPLA, 2015.

  15. Theory of Random Anisotropic Magnetic Alloys

    DEFF Research Database (Denmark)

    Lindgård, Per-Anker

    1976-01-01

    A mean-field-crystal-field theory is developed for random, multicomponent, anisotropic magnetic alloys. It is specially applicable to rare-earth alloys. A discussion is given of multicritical points and phase transitions between various states characterized by order parameters with different...... spatial directions or different ordering wave vectors. Theoretical predictions based on known parameters for the phase diagrams and magnetic moments for the binary rare-earth alloys of Tb, Dy, Ho, and Er, Tb-Tm, Nd-Pr, and pure double-hcp Nd agree qualitatively with the experimental observations....... Quantitative agreement can be obtained by increasing the interaction between different alloy elements, in particular for alloys with very different axial anisotropy, e.g., Tb-Tm. A model system consisting of a singlet-singlet and singlet-doublet alloy is discussed in detail. A simple procedure to include...

  16. Patterning of Structurally Anisotropic Composite Hydrogel Sheets.

    Science.gov (United States)

    Prince, Elisabeth; Alizadehgiashi, Moien; Campbell, Melissa; Khuu, Nancy; Albulescu, Alexandra; De France, Kevin; Ratkov, Dimitrije; Li, Yunfeng; Hoare, Todd; Kumacheva, Eugenia

    2018-04-09

    Compositional and structural patterns play a crucial role in the function of many biological tissues. In the present work, for nanofibrillar hydrogels formed by chemically cross-linked cellulose nanocrystals (CNC) and gelatin, we report a microextrusion-based 3D printing method to generate structurally anisotropic hydrogel sheets with CNCs aligned in the direction of extrusion. We prepared hydrogels with a uniform composition, as well as hydrogels with two different types of compositional gradients. In the first type of gradient hydrogel, the composition of the sheet varied parallel to the direction of CNC alignment. In the second hydrogel type, the composition of the sheet changed orthogonally to the direction of CNC alignment. The hydrogels exhibited gradients in structure, mechanical properties, and permeability, all governed by the compositional patterns, as well as cytocompatibility. These hydrogels have promising applications for both fundamental research and for tissue engineering and regenerative medicine.

  17. Silicon as an anisotropic mechanical material

    DEFF Research Database (Denmark)

    Thomsen, Erik Vilain; Reck, Kasper; Skands, Gustav Erik

    2014-01-01

    While silicon is an anisotropic material it is often in literature treated as an isotropic material when it comes to plate calculations. This leads to considerable errors in the calculated deflection. To overcome this problem, we present an in-depth analysis of the bending behavior of thin...... both exact analytical expressions and approximate expressions calculated by the Galerkin method. The results are applied to plates made on silicon (0 0 1), (0 1 1) and (1 1 1) substrates, respectively, and analytical equations for the deflection, strain energy and resonance frequency of such plates...... analytical models involving crystalline plates, such as those often found in the field of micro electro mechanical systems. The effect of elastic boundary conditions is taken into account by using an effective radius of the plate....

  18. Anisotropic dynamic mass density for fluidsolid composites

    KAUST Repository

    Wu, Ying

    2012-10-01

    By taking the low frequency limit of multiple-scattering theory, we obtain the dynamic effective mass density of fluidsolid composites with a two-dimensional rectangular lattice structure. The anisotropic mass density can be described by an angle-dependent dipole solution, to the leading-order of solid concentration. The angular dependence vanishes for the square lattice, but at high solid concentrations there is a structure-dependent factor that contributes to the leading-order solution. In all cases, Woods formula is found to be accurately valid for the effective bulk modulus, independent of the structures. Numerical evaluations from the solutions are shown to be in excellent agreement with finite-element simulations. © 2012 Elsevier B.V.

  19. Spectral functions from anisotropic lattice QCD

    Science.gov (United States)

    Aarts, G.; Allton, C.; Amato, A.; Evans, W.; Giudice, P.; Harris, T.; Kelly, A.; Kim, S. Y.; Lombardo, M. P.; Praki, K.; Ryan, S. M.; Skullerud, J.-I.

    2016-12-01

    The FASTSUM collaboration has been carrying out lattice simulations of QCD for temperatures ranging from one third to twice the crossover temperature, investigating the transition region, as well as the properties of the Quark Gluon Plasma. In this contribution we concentrate on quarkonium correlators and spectral functions. We work in a fixed scale scheme and use anisotropic lattices which help achieving the desirable fine resolution in the temporal direction, thus facilitating the (ill posed) integral transform from imaginary time to frequency space. We contrast and compare results for the correlators obtained with different methods, and different temporal spacings. We observe robust features of the results, confirming the sequential dissociation scenario, but also quantitative differences indicating that the methods' systematic errors are not yet under full control. We briefly outline future steps towards accurate results for the spectral functions and their associated statistical and systematic errors.

  20. Derivation of the optical constants of anisotropic

    Science.gov (United States)

    Aronson, J. R.; Emslie, A. G.; Smith, E. M.; Strong, P. F.

    1985-07-01

    This report concerns the development of methods for obtaining the optical constants of anisotropic crystals of the triclinic and monoclinic systems. The principal method used, classical dispersion theory, is adapted to these crystal systems by extending the Lorentz line parameters to include the angles characterizing the individual resonances, and by replacing the dielectric constant by a dielectric tensor. The sample crystals are gypsium, orthoclase and chalcanthite. The derived optical constants are shown to be suitable for modeling the optical properties of particulate media in the infrared spectral region. For those materials where suitable size single crystals are not available, an extension of a previously used method is applied to alabaster, a polycrystalline material of the monoclinic crystal system.

  1. Anisotropic thermal expansion in flexible materials

    Science.gov (United States)

    Romao, Carl P.

    2017-10-01

    A definition of the Grüneisen parameters for anisotropic materials is derived based on the response of phonon frequencies to uniaxial stress perturbations. This Grüneisen model relates the thermal expansion in a given direction (αi i) to one element of the elastic compliance tensor, which corresponds to the Young's modulus in that direction (Yi i). The model is tested through ab initio prediction of thermal expansion in zinc, graphite, and calcite using density functional perturbation theory, indicating that it could lead to increased accuracy for structurally complex systems. The direct dependence of αi i on Yi i suggests that materials which are flexible along their principal axes but rigid in other directions will generally display both positive and negative thermal expansion.

  2. The Anisotropic Glassy Properties of Decagonal Quasicrystals

    Directory of Open Access Journals (Sweden)

    Dragoş-Victor Anghel

    2013-01-01

    Full Text Available We use an extended version of the standard tunneling model to explain the anisotropic sound absorption in decagonal quasicrystals. The glassy properties are determined by an ensemble of two level systems (TLSs, arbitrarily oriented. The TLS is characterized by a 3 × 3 symmetric tensor, [T], which couples to the strain field, [S], through a 3 × 3 × 3 × 3 tensor of coupling constants, [R]. The structure of [R] reflects the symmetry of the quasicrystal. We also analyze the probability distributions of the elements of [T] in this particular model for a better understanding of the characteristics of “isotropic” and “anisotropic” distributions of the ensemble of TLSs. We observe that the distribution of the elements is neither simple nor intuitive and therefore it is difficult to guess it a priory, using qualitative arguments based on the symmetry properties.

  3. Final fate of charged anisotropic fluid collapse

    Science.gov (United States)

    Khan, Suhail; Shah, Hassan; Ahmad, Zahid; Ramzan, Muhammad

    2017-11-01

    This paper studies the effects of charge on spherically symmetric collapse of anisotropic fluid with a positive cosmological constant. It is observed that electromagnetic field places restriction on the bounds of cosmological constant, which acts as repulsive force against the contraction of matter content and hence the rate of destruction is faster in the presence of electromagnetic field. We have also noted that the presence of charge affects the time interval between the formation of cosmological horizon (CH) and black hole horizon (BHH). When the electric field strength E(t, r) vanishes, our investigations are in full agreement with the results obtained by Ahmad and Malik [Int. J. Theor. Phys. 55, 600 (2016)].

  4. Adiabatic theory for anisotropic cold molecule collisions

    Energy Technology Data Exchange (ETDEWEB)

    Pawlak, Mariusz [Schulich Faculty of Chemistry, Technion–Israel Institute of Technology, Haifa 32000 (Israel); Faculty of Chemistry, Nicolaus Copernicus University in Toruń, Gagarina 7, 87-100 Toruń (Poland); Shagam, Yuval; Narevicius, Edvardas [Department of Chemical Physics, Weizmann Institute of Science, Rehovot 76100 (Israel); Moiseyev, Nimrod [Schulich Faculty of Chemistry, Technion–Israel Institute of Technology, Haifa 32000 (Israel); Faculty of Physics, Technion–Israel Institute of Technology, Haifa 32000 (Israel)

    2015-08-21

    We developed an adiabatic theory for cold anisotropic collisions between slow atoms and cold molecules. It enables us to investigate the importance of the couplings between the projection states of the rotational motion of the atom about the molecular axis of the diatom. We tested our theory using the recent results from the Penning ionization reaction experiment {sup 4}He(1s2s {sup 3}S) + HD(1s{sup 2}) → {sup 4}He(1s{sup 2}) + HD{sup +}(1s) + e{sup −} [Lavert-Ofir et al., Nat. Chem. 6, 332 (2014)] and demonstrated that the couplings have strong effect on positions of shape resonances. The theory we derived provides cross sections which are in a very good agreement with the experimental findings.

  5. Effective stress law for anisotropic elastic deformation

    International Nuclear Information System (INIS)

    Carroll, M.M.

    1979-01-01

    An effective stress law is derived analytically to describe the effect of pore fluid pressure on the linearly elastic response of saturated porous rocks which exhibit anisotropy. For general anisotropy the difference between the effective stress and the applied stress is not hydrostatic. The effective stress law involves two constants for transversely isotropic response and three constants for orthotropic response; these constants can be expressed in terms of the moduli of the porous material and of the solid material. These expressions simplify considerably when the anisotropy is structural rather than intrinsic, i.e., in the case of an isotropic solid material with an anisotropic pore structure. In this case the effective stress law involves the solid or grain bulk modulus and two or three moduli of the porous material, for transverse isotropy and orthotropy, respectively. The law reduces, in the case of isotropic response, to that suggested by Geertsma (1957) and by Skempton (1961) and derived analytically by Nur and Byerlee

  6. A FDM anisotropic formulation for EEG simulation.

    Science.gov (United States)

    Bruno, P; Hyttinen, J; Inchingolo, P; Magrofuoco, A; Mininel, S; Vatta, F

    2006-01-01

    Accurate head modeling is required to properly simulate bioelectric phenomena in 3-D as well as to estimate the 3-D bioelectric activity starting from superficial bioelectric measurements and 3-D imaging. Aiming to build an accurate and realistic representation of the volume conductor of the head, also the anisotropy of head tissues should be taken into account. In this paper we describe a new finite-difference method (FDM) formulation which accounts for anisotropy of the various head tissues. Our proposal, being based on FDM, derives the head model directly from patient's specific clinical images. We present here the details of the numerical formulation and the method validation by comparing our numerical proposal and known analytical results using a multi-shell anisotropic head model with skull anisotropy. Furthermore, we analyzed also different numerical grid refinement and EEG source characteristics. The comparison with previously developed FDM methods shows a good performance of the proposed method.

  7. Anisotropic magnetism in field-structured composites

    International Nuclear Information System (INIS)

    Martin, James E.; Venturini, Eugene; Odinek, Judy; Anderson, Robert A.

    2000-01-01

    Magnetic field-structured composites (FSCs) are made by structuring magnetic particle suspensions in uniaxial or biaxial (e.g., rotating) magnetic fields, while polymerizing the suspending resin. A uniaxial field produces chainlike particle structures, and a biaxial field produces sheetlike particle structures. In either case, these anisotropic structures affect the measured magnetic hysteresis loops, with the magnetic remanence and susceptibility increased significantly along the axis of the structuring field, and decreased slightly orthogonal to the structuring field, relative to the unstructured particle composite. The coercivity is essentially unaffected by structuring. We present data for FSCs of magnetically soft particles, and demonstrate that the altered magnetism can be accounted for by considering the large local fields that occur in FSCs. FSCs of magnetically hard particles show unexpectedly large anisotropies in the remanence, and this is due to the local field effects in combination with the large crystalline anisotropy of this material. (c) 2000 The American Physical Society

  8. An Anisotropic Hardening Model for Springback Prediction

    International Nuclear Information System (INIS)

    Zeng, Danielle; Xia, Z. Cedric

    2005-01-01

    As more Advanced High-Strength Steels (AHSS) are heavily used for automotive body structures and closures panels, accurate springback prediction for these components becomes more challenging because of their rapid hardening characteristics and ability to sustain even higher stresses. In this paper, a modified Mroz hardening model is proposed to capture realistic Bauschinger effect at reverse loading, such as when material passes through die radii or drawbead during sheet metal forming process. This model accounts for material anisotropic yield surface and nonlinear isotropic/kinematic hardening behavior. Material tension/compression test data are used to accurately represent Bauschinger effect. The effectiveness of the model is demonstrated by comparison of numerical and experimental springback results for a DP600 straight U-channel test

  9. Recent developments in anisotropic heterogeneous shell theory

    CERN Document Server

    Grigorenko, Alexander Ya; Grigorenko, Yaroslav M; Vlaikov, Georgii G

    2016-01-01

    This volume focuses on the relevant general theory and presents some first applications, namely those based on classical shell theory. After a brief introduction, during which the history and state-of-the-art are discussed, the first chapter presents the mechanics of anisotropic heterogeneous shells, covering all relevant assumptions and the basic relations of 3D elasticity, classical and refined shell models. The second chapter examines the numerical techniques that are used, namely discrete orthogonalization, spline-collocation and Fourier series, while the third highlights applications based on classical theory, in particular, the stress-strain state of shallow shells, non-circular shells, shells of revolution, and free vibrations of conical shells. The book concludes with a summary and an outlook bridging the gap to the second volume.

  10. Effective orthorhombic anisotropic models for wavefield extrapolation

    KAUST Repository

    Ibanez-Jacome, W.

    2014-07-18

    Wavefield extrapolation in orthorhombic anisotropic media incorporates complicated but realistic models to reproduce wave propagation phenomena in the Earth\\'s subsurface. Compared with the representations used for simpler symmetries, such as transversely isotropic or isotropic, orthorhombic models require an extended and more elaborated formulation that also involves more expensive computational processes. The acoustic assumption yields more efficient description of the orthorhombic wave equation that also provides a simplified representation for the orthorhombic dispersion relation. However, such representation is hampered by the sixth-order nature of the acoustic wave equation, as it also encompasses the contribution of shear waves. To reduce the computational cost of wavefield extrapolation in such media, we generate effective isotropic inhomogeneous models that are capable of reproducing the firstarrival kinematic aspects of the orthorhombic wavefield. First, in order to compute traveltimes in vertical orthorhombic media, we develop a stable, efficient and accurate algorithm based on the fast marching method. The derived orthorhombic acoustic dispersion relation, unlike the isotropic or transversely isotropic ones, is represented by a sixth order polynomial equation with the fastest solution corresponding to outgoing P waves in acoustic media. The effective velocity models are then computed by evaluating the traveltime gradients of the orthorhombic traveltime solution, and using them to explicitly evaluate the corresponding inhomogeneous isotropic velocity field. The inverted effective velocity fields are source dependent and produce equivalent first-arrival kinematic descriptions of wave propagation in orthorhombic media. We extrapolate wavefields in these isotropic effective velocity models using the more efficient isotropic operator, and the results compare well, especially kinematically, with those obtained from the more expensive anisotropic extrapolator.

  11. Cardiovascular molecular imaging of apoptosis

    International Nuclear Information System (INIS)

    Wolters, S.L.; Reutelingsperger, C.P.M.; Corsten, M.F.; Hofstra, L.; Narula, J.

    2007-01-01

    Molecular imaging strives to visualise processes at the molecular and cellular level in vivo. Understanding these processes supports diagnosis and evaluation of therapeutic efficacy on an individual basis and thereby makes personalised medicine possible. Apoptosis is a well-organised mode of cell suicide that plays a role in cardiovascular diseases (CVD). Apoptosis is associated with loss of cardiomyocytes following myocardial infarction, atherosclerotic plaque instability, congestive heart failure and allograft rejection of the transplanted heart. Thus, apoptosis constitutes an attractive target for molecular imaging of CVD. Our current knowledge about the molecular players and mechanisms underlying apoptosis offers a rich palette of potential molecular targets for molecular imaging. However, only a few have been successfully developed so far. This review highlights aspects of the molecular machinery and biochemistry of apoptosis relevant to the development of molecular imaging probes. It surveys the role of apoptosis in four major areas of CVD and portrays the importance and future perspectives of apoptosis imaging. The annexin A5 imaging protocol is emphasised since it is the most advanced protocol to measure apoptosis in both preclinical and clinical studies. (orig.)

  12. Cardiovascular molecular imaging of apoptosis

    Energy Technology Data Exchange (ETDEWEB)

    Wolters, S.L.; Reutelingsperger, C.P.M. [Maastricht University, Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht (Netherlands); Corsten, M.F.; Hofstra, L. [Maastricht University, Department of Cardiology, Cardiovascular Research Institute Maastricht, P.O. Box 616, Maastricht (Netherlands); Narula, J. [University of California Irvine, Department of Cardiology, Irvine (United States)

    2007-06-15

    Molecular imaging strives to visualise processes at the molecular and cellular level in vivo. Understanding these processes supports diagnosis and evaluation of therapeutic efficacy on an individual basis and thereby makes personalised medicine possible. Apoptosis is a well-organised mode of cell suicide that plays a role in cardiovascular diseases (CVD). Apoptosis is associated with loss of cardiomyocytes following myocardial infarction, atherosclerotic plaque instability, congestive heart failure and allograft rejection of the transplanted heart. Thus, apoptosis constitutes an attractive target for molecular imaging of CVD. Our current knowledge about the molecular players and mechanisms underlying apoptosis offers a rich palette of potential molecular targets for molecular imaging. However, only a few have been successfully developed so far. This review highlights aspects of the molecular machinery and biochemistry of apoptosis relevant to the development of molecular imaging probes. It surveys the role of apoptosis in four major areas of CVD and portrays the importance and future perspectives of apoptosis imaging. The annexin A5 imaging protocol is emphasised since it is the most advanced protocol to measure apoptosis in both preclinical and clinical studies. (orig.)

  13. Tunneling anisotropic magnetoresistance driven by magnetic phase transition.

    Science.gov (United States)

    Chen, X Z; Feng, J F; Wang, Z C; Zhang, J; Zhong, X Y; Song, C; Jin, L; Zhang, B; Li, F; Jiang, M; Tan, Y Z; Zhou, X J; Shi, G Y; Zhou, X F; Han, X D; Mao, S C; Chen, Y H; Han, X F; Pan, F

    2017-09-06

    The independent control of two magnetic electrodes and spin-coherent transport in magnetic tunnel junctions are strictly required for tunneling magnetoresistance, while junctions with only one ferromagnetic electrode exhibit tunneling anisotropic magnetoresistance dependent on the anisotropic density of states with no room temperature performance so far. Here, we report an alternative approach to obtaining tunneling anisotropic magnetoresistance in α'-FeRh-based junctions driven by the magnetic phase transition of α'-FeRh and resultantly large variation of the density of states in the vicinity of MgO tunneling barrier, referred to as phase transition tunneling anisotropic magnetoresistance. The junctions with only one α'-FeRh magnetic electrode show a magnetoresistance ratio up to 20% at room temperature. Both the polarity and magnitude of the phase transition tunneling anisotropic magnetoresistance can be modulated by interfacial engineering at the α'-FeRh/MgO interface. Besides the fundamental significance, our finding might add a different dimension to magnetic random access memory and antiferromagnet spintronics.Tunneling anisotropic magnetoresistance is promising for next generation memory devices but limited by the low efficiency and functioning temperature. Here the authors achieved 20% tunneling anisotropic magnetoresistance at room temperature in magnetic tunnel junctions with one α'-FeRh magnetic electrode.

  14. Effect of pH on radiation-induced apoptosis

    International Nuclear Information System (INIS)

    Chang, W. Song; Park, Heon J.; Lyons, John C.; Auger, Elizabeth A.; Lee, Hyung-Sik

    1996-01-01

    Purpose/Objective: The effect of environmental pH on the radiation-induced apoptosis in tumor cells in vitro was investigated. Materials and Methods: SCK mammary adenocarcinoma cells of A/J mice were irradiated with γ-rays using a 137 Cs irradiator and incubated in media of different pHs. After incubation at 37 degree sign C for 24-120 hrs., the extent of apoptosis was determined using agarose gel electrophoresis of DNA, in situ TUNEL staining, flow cytometry, and release of 3 H from 3 H-thymidine labeled cells. The membrane integrity, using the trypan blue exclusion method, and the clonogenicity of the cells were also determined. Results: Irradiation with 2-12 Gy of γ-rays induced apoptosis in pH 7.5 medium within 48 hrs. The radiation-induced apoptosis progressively declined as the medium pH was lowered so that little apoptosis occurred in 48 hrs. after irradiation with 12 Gy in pH 6.6 medium. However, when the cells were irradiated and incubated for 48 hrs. in pH 6.6 medium and then medium was replaced with pH 7.5 medium, apoptosis promptly occurred. Apoptosis also occurred even in pH 6.6 medium when the cells were irradiated and maintained in pH 7.5 medium for 8 hrs. or longer post-irradiation before incubation in pH 6.6 medium. Conclusion: An acidic environment markedly suppresses radiation-induced apoptosis probably by suppressing the expression of initial signals responsible for irradiation-induced apoptosis. Indications are that the signals persist in an acidic environment and trigger apoptosis when the environmental acidity is eased. Our results suggest that the acidic environment in human tumors may inhibit the apoptosis after irradiation. However, apoptosis may be triggered when reoxygenation occurs after irradiation, and thus, the intratumor environment becomes less acidic after irradiation. Not only the change in pO 2 but the change in pH during the course of fractionated radiotherapy may greatly influence the outcome of the treatment

  15. Anisotropic Conductivity Tensor Imaging of In Vivo Canine Brain Using DT-MREIT.

    Science.gov (United States)

    Jeong, Woo Chul; Sajib, Saurav Z K; Katoch, Nitish; Kim, Hyung Joong; Kwon, Oh In; Woo, Eung Je

    2017-01-01

    We present in vivo images of anisotropic electrical conductivity tensor distributions inside canine brains using diffusion tensor magnetic resonance electrical impedance tomography (DT-MREIT). The conductivity tensor is represented as a product of an ion mobility tensor and a scale factor of ion concentrations. Incorporating directional mobility information from water diffusion tensors, we developed a stable process to reconstruct anisotropic conductivity tensor images from measured magnetic flux density data using an MRI scanner. Devising a new image reconstruction algorithm, we reconstructed anisotropic conductivity tensor images of two canine brains with a pixel size of 1.25 mm. Though the reconstructed conductivity values matched well in general with those measured by using invasive probing methods, there were some discrepancies as well. The degree of white matter anisotropy was 2 to 4.5, which is smaller than previous findings of 5 to 10. The reconstructed conductivity value of the cerebrospinal fluid was about 1.3 S/m, which is smaller than previous measurements of about 1.8 S/m. Future studies of in vivo imaging experiments with disease models should follow this initial trial to validate clinical significance of DT-MREIT as a new diagnostic imaging modality. Applications in modeling and simulation studies of bioelectromagnetic phenomena including source imaging and electrical stimulation are also promising.

  16. On the Schrodinger equations with isotropic and anisotropic fourth-order dispersion

    Directory of Open Access Journals (Sweden)

    Elder J. Villamizar-Roa

    2016-01-01

    Full Text Available This article concerns the Cauchy problem associated with the nonlinear fourth-order Schrodinger equation with isotropic and anisotropic mixed dispersion. This model is given by the equation $$ i\\partial_tu+\\epsilon \\Delta u+\\delta A u+\\lambda|u|^\\alpha u=0,\\quad x\\in\\mathbb{R}^{n},\\; t\\in \\mathbb{R}, $$ where A is either the operator $\\Delta^2$ (isotropic dispersion or $\\sum_{i=1}^d\\partial_{x_ix_ix_ix_i}$, $1\\leq danisotropic dispersion, and $\\alpha, \\epsilon, \\lambda$ are real parameters. We obtain local and global well-posedness results in spaces of initial data with low regularity, based on weak-$L^p$ spaces. Our analysis also includes the biharmonic and anisotropic biharmonic equation $(\\epsilon=0$; in this case, we obtain the existence of self-similar solutions because of their scaling invariance property. In a second part, we analyze the convergence of solutions for the nonlinear fourth-order Schrodinger equation $$ i\\partial_tu+\\epsilon \\Delta u+\\delta \\Delta^2 u+\\lambda|u|^\\alpha u=0, \\quad x\\in\\mathbb{R}^{n},\\; t\\in \\mathbb{R}, $$ as $\\epsilon$ approaches zero, in the $H^2$-norm, to the solutions of the corresponding biharmonic equation $i\\partial_tu+\\delta \\Delta^2 u+\\lambda|u|^\\alpha u=0$.

  17. Development of laser ablation plasma by anisotropic self-radiation

    Directory of Open Access Journals (Sweden)

    Ohnishi Naofumi

    2013-11-01

    Full Text Available We have proposed a method for reproducing an accurate solution of low-density ablation plasma by properly treating anisotropic radiation. Monte-Carlo method is employed for estimating Eddington tensor with limited number of photon samples in each fluid time step. Radiation field from ablation plasma is significantly affected by the anisotropic Eddington tensor. Electron temperature around the ablation surface changes with the radiation field and is responsible for the observed emission. An accurate prediction of the light emission from the laser ablation plasma requires a careful estimation of the anisotropic radiation field.

  18. Glycolaldehyde induces endoplasmic reticulum stress and apoptosis in Schwann cells

    Directory of Open Access Journals (Sweden)

    Keisuke Sato

    2015-01-01

    Full Text Available Schwann cell injury is caused by diabetic neuropathy. The apoptosis of Schwann cells plays a pivotal role in diabetic nerve dysfunction. Glycolaldehyde is a precursor of advanced glycation end products that contribute to the pathogenesis of diabetic neuropathy. In this study, we examined whether glycolaldehyde induces endoplasmic reticulum (ER stress and apoptosis in rat Schwann cells. Schwann cells treated with 500 μM glycolaldehyde showed morphological changes characteristic of apoptosis. Glycolaldehyde activated apoptotic signals, such as caspase-3 and caspase-8. Furthermore, it induced ER stress response involving RNA-dependent protein kinase-like ER kinase (PERK, inositol-requiring ER-to-nucleus signal kinase 1α (IRE1α, and eukaryotic initiation factor 2α (eIF2α. In addition, glycolaldehyde activated CCAAT/enhancer-binding homologous protein (CHOP, an ER stress response factor crucial to executing apoptosis. Knockdown of nuclear factor E2-related factor 2 (Nrf2, which is involved in the promotion of cell survival following ER stress, enhanced glycolaldehyde-induced cytotoxicity, indicating that Nrf2 plays a protective role in the cytotoxicity caused by glycolaldehyde. Taken together, these findings indicate that glycolaldehyde is capable of inducing apoptosis and ER stress in Schwann cells. The ER stress induced by glycolaldehyde may trigger the glycolaldehyde-induced apoptosis in Schwann cells. This study demonstrated for the first time that glycolaldehyde induced ER stress.

  19. Drug-induced reactivation of apoptosis abrogates HIV-1 infection.

    Directory of Open Access Journals (Sweden)

    Hartmut M Hanauske-Abel

    Full Text Available HIV-1 blocks apoptosis, programmed cell death, an innate defense of cells against viral invasion. However, apoptosis can be selectively reactivated in HIV-infected cells by chemical agents that interfere with HIV-1 gene expression. We studied two globally used medicines, the topical antifungal ciclopirox and the iron chelator deferiprone, for their effect on apoptosis in HIV-infected H9 cells and in peripheral blood mononuclear cells infected with clinical HIV-1 isolates. Both medicines activated apoptosis preferentially in HIV-infected cells, suggesting that the drugs mediate escape from the viral suppression of defensive apoptosis. In infected H9 cells, ciclopirox and deferiprone enhanced mitochondrial membrane depolarization, initiating the intrinsic pathway of apoptosis to execution, as evidenced by caspase-3 activation, poly(ADP-ribose polymerase proteolysis, DNA degradation, and apoptotic cell morphology. In isolate-infected peripheral blood mononuclear cells, ciclopirox collapsed HIV-1 production to the limit of viral protein and RNA detection. Despite prolonged monotherapy, ciclopirox did not elicit breakthrough. No viral re-emergence was observed even 12 weeks after drug cessation, suggesting elimination of the proviral reservoir. Tests in mice predictive for cytotoxicity to human epithelia did not detect tissue damage or activation of apoptosis at a ciclopirox concentration that exceeded by orders of magnitude the concentration causing death of infected cells. We infer that ciclopirox and deferiprone act via therapeutic reclamation of apoptotic proficiency (TRAP in HIV-infected cells and trigger their preferential elimination. Perturbations in viral protein expression suggest that the antiretroviral activity of both drugs stems from their ability to inhibit hydroxylation of cellular proteins essential for apoptosis and for viral infection, exemplified by eIF5A. Our findings identify ciclopirox and deferiprone as prototypes of

  20. Reinterpreting aircraft measurements in anisotropic scaling turbulence

    Directory of Open Access Journals (Sweden)

    S. J. Hovde

    2009-07-01

    Full Text Available Due to both systematic and turbulent induced vertical fluctuations, the interpretation of atmospheric aircraft measurements requires a theory of turbulence. Until now virtually all the relevant theories have been isotropic or "quasi isotropic" in the sense that their exponents are the same in all directions. However almost all the available data on the vertical structure shows that it is scaling but with exponents different from the horizontal: the turbulence is scaling but anisotropic. In this paper, we show how such turbulence can lead to spurious breaks in the scaling and to the spurious appearance of the vertical scaling exponent at large horizontal lags.

    We demonstrate this using 16 legs of Gulfstream 4 aircraft near the top of the troposphere following isobars each between 500 and 3200 km in length. First we show that over wide ranges of scale, the horizontal spectra of the aircraft altitude are nearly k-5/3. In addition, we show that the altitude and pressure fluctuations along these fractal trajectories have a high degree of coherence with the measured wind (especially with its longitudinal component. There is also a strong phase relation between the altitude, pressure and wind fluctuations; for scales less than ≈40 km (on average the wind fluctuations lead the pressure and altitude, whereas for larger scales, the pressure fluctuations leads the wind. At the same transition scale, there is a break in the wind spectrum which we argue is caused by the aircraft starting to accurately follow isobars at the larger scales. In comparison, the temperature and humidity have low coherencies and phases and there are no apparent scale breaks, reinforcing the hypothesis that it is the aircraft trajectory that is causally linked to the scale breaks in the wind measurements.

    Using spectra and structure functions for the wind, we then estimate their exponents (β, H at small (5/3, 1/3 and large scales (2

  1. BIGH3 protein and macrophages in retinal endothelial cell apoptosis.

    Science.gov (United States)

    Mondragon, Albert A; Betts-Obregon, Brandi S; Moritz, Robert J; Parvathaneni, Kalpana; Navarro, Mary M; Kim, Hong Seok; Lee, Chi Fung; LeBaron, Richard G; Asmis, Reto; Tsin, Andrew T

    2015-01-01

    Diabetes is a pandemic disease with a higher occurrence in minority populations. The molecular mechanism to initiate diabetes-associated retinal angiogenesis remains largely unknown. We propose an inflammatory pathway of diabetic retinopathy in which macrophages in the diabetic eye provide TGFβ to retinal endothelial cells (REC) in the retinal microvasculature. In response to TGFβ, REC synthesize and secrete a pro-apoptotic BIGH3 (TGFβ-Induced Gene Human Clone 3) protein, which acts in an autocrine loop to induce REC apoptosis. Rhesus monkey retinal endothelial cells (RhREC) were treated with dMCM (cell media of macrophages treated with high glucose and LDL) and assayed for apoptosis (TUNEL), BIGH3 mRNA (qPCR), and protein (Western blots) expressions. Cells were also treated with ΤGFβ1 and 2 for BIGH3 mRNA and protein expression. Inhibition assays were carried out using antibodies for TGFβ1 and for BIGH3 to block apoptosis and mRNA expression. BIGH3 in cultured RhREC cells were identified by immunohistochemistry (IHC). Distribution of BIGH3 and macrophages in the diabetic mouse retina was examined with IHC. RhRECs treated with dMCM or TGFβ showed a significant increase in apoptosis and BIGH3 protein expression. Recombinant BIGH3 added to RhREC culture medium led to a dose-dependent increase in apoptosis. Antibodies (Ab) directed against BIGH3 and TGFβ, as well as TGFβ receptor blocker resulted in a significant reduction in apoptosis induced by either dMCM, TGFβ or BIGH3. IHC showed that cultured RhREC constitutively expressed BIGH3. Macrophage and BIGH3 protein were co-localized to the inner retina of the diabetic mouse eye. Our results support a novel inflammatory pathway for diabetic retinopathy. This pathway is initiated by TGFβ released from macrophages, which promotes synthesis and release of BIGH3 protein by REC and REC apoptosis.

  2. Hydrodynamic cavitation in Stokes flow of anisotropic fluids.

    Science.gov (United States)

    Stieger, Tillmann; Agha, Hakam; Schoen, Martin; Mazza, Marco G; Sengupta, Anupam

    2017-05-30

    Cavitation, the nucleation of vapour in liquids, is ubiquitous in fluid dynamics, and is often implicated in a myriad of industrial and biomedical applications. Although extensively studied in isotropic liquids, corresponding investigations in anisotropic liquids are largely lacking. Here, by combining liquid crystal microfluidic experiments, nonequilibrium molecular dynamics simulations and theoretical arguments, we report flow-induced cavitation in an anisotropic fluid. The cavitation domain nucleates due to sudden pressure drop upon flow past a cylindrical obstacle within a microchannel. For an anisotropic fluid, the inception and growth of the cavitation domain ensued in the Stokes regime, while no cavitation was observed in isotropic liquids flowing under similar hydrodynamic parameters. Using simulations we identify a critical value of the Reynolds number for cavitation inception that scales inversely with the order parameter of the fluid. Strikingly, the critical Reynolds number for anisotropic fluids can be 50% lower than that of isotropic fluids.

  3. Liquid Crystal Elastomer Actuators from Anisotropic Porous Polymer Template.

    Science.gov (United States)

    Wang, Qian; Yu, Li; Yu, Meina; Zhao, Dongyu; Song, Ping; Chi, Hun; Guo, Lin; Yang, Huai

    2017-08-01

    Controlling self-assembly behaviors of liquid crystals is a fundamental issue for designing them as intelligent actuators. Here, anisotropic porous polyvinylidene fluoride film is utilized as a template to induce homogeneous alignment of liquid crystals. The mechanism of liquid crystal alignment induced by anisotropic porous polyvinylidene fluoride film is illustrated based on the relationship between the alignment behavior of liquid crystals and surface microstructure of anisotropic polyvinylidene fluoride film. Liquid crystal elastomer actuators with fast responsiveness, large strain change, and reversible actuation behaviors are achieved by the photopolymerization of liquid crystal monomer in liquid crystal cells coated with anisotropic porous films. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  4. Acoustic frequency filter based on anisotropic topological phononic crystals

    KAUST Repository

    Chen, Zeguo

    2017-11-02

    We present a design of acoustic frequency filter based on a two-dimensional anisotropic phononic crystal. The anisotropic band structure exhibits either a directional or a combined (global + directional) bandgap at certain frequency regions, depending on the geometry. When the time-reversal symmetry is broken, it may introduce a topologically nontrivial bandgap. The induced nontrivial bandgap and the original directional bandgap result in various interesting wave propagation behaviors, such as frequency filter. We develop a tight-binding model to characterize the effective Hamiltonian of the system, from which the contribution of anisotropy is explicitly shown. Different from the isotropic cases, the Zeeman-type splitting is not linear and the anisotropic bandgap makes it possible to achieve anisotropic propagation characteristics along different directions and at different frequencies.

  5. Two-dimensional static deformation of an anisotropic medium

    Indian Academy of Sciences (India)

    1989). Chou (1976) and Ting (1995) discussed antiplane strain deformation of an anisotropic medium. Garg et al (1996) obtained representations of seismic sources causing antiplane strain deformations of orthotropic media. The corresponding ...

  6. Change of energy of photons passing through rotating anisotropic elements

    CERN Document Server

    Bagini, V; Santarsiero, M; Frezza, F; Schettini, G; Schirripa-Spagnolo, G

    1994-01-01

    We discuss simple experiments where the concept of angular momentum of a photon can be put to use in order to explain the photon energy changes that are produced by the passage of light beams through rotating anisotropic elements. (author)

  7. Spin and orbital angular momentum propagation in anisotropic media: theory

    International Nuclear Information System (INIS)

    Picón, Antonio; Benseny, Albert; Mompart, Jordi; Calvo, Gabriel F

    2011-01-01

    This paper is devoted to a study of the propagation of light beams carrying orbital angular momentum in optically anisotropic media. We first review some properties of homogeneous anisotropic media, and describe how the paraxial formalism is modified in order to proceed with a new approach dealing with the general setting of paraxial propagation along uniaxial inhomogeneous media. This approach is suitable for describing space-variant optical-axis phase plates

  8. Hybrid anisotropic materials for wind power turbine blades

    CERN Document Server

    Golfman, Yosif

    2012-01-01

    Based on rapid technological developments in wind power, governments and energy corporations are aggressively investing in this natural resource. Illustrating some of the crucial new breakthroughs in structural design and application of wind energy generation machinery, Hybrid Anisotropic Materials for Wind Power Turbine Blades explores new automated, repeatable production techniques that expand the use of robotics and process controls. These practices are intended to ensure cheaper fabrication of less-defective anisotropic material composites used to manufacture power turbine blades. This boo

  9. Stress propagation in isotropic packs with anisotropic boundaries

    Science.gov (United States)

    Krapf, Nathan; Witten, Thomas

    2010-03-01

    Stresses in marginally jammed, anisotropic packs built up from a solid floor propagate along oblique rays toward the floor footnotetext D. A. Head, A. V. Tkachenko, and T. A. Witten. Eur. Phys. J. E 6, 99-105 (2001)). This clear anisotropic propagation must result from anisotropic packing and/or anisotropic boundary conditions. Here we numerically isolate the effect of anisotropic boundaries by using an explicitly isotropic periodic pack in a marginally jammed, isostatic state. We then remove the periodicity in one direction and anchor the beads along one edge to a substrate. This preserves the isostatic condition while rendering the boundary anisotropic. However, we find hyperstatic modes along one edge of the pack and hypostatic modes at the other. We show that these extra modes decay rapidly away from the boundaries. Remarkably the hypostatic modes cause the pack to be unstable under any force applied to a single bead. This instability can be remedied by applying a suitable cluster of forces to adjacent beads, allowing a clear measurement of the bulk response. We discuss the resulting stress response.

  10. Effect of irregularity on torsional surface waves in an initially ...

    Indian Academy of Sciences (India)

    Effect of irregularity on torsional surface waves in an initially stressed anisotropic porous layer sandwiched between homogeneous and non-homogeneous half- ... Torsional wave; anisotropy; initial stress; irregularity; non-homogeneity ... Department of Applied Mathematics, Indian School of Mines, Dhanbad 826 004, India.

  11. Microstructure evolution of hot-deformed Nd-Fe-B anisotropic magnets

    Energy Technology Data Exchange (ETDEWEB)

    Liu, J., E-mail: liu.jun@nims.go.jp; Hono, K. [Elements Strategy Initiative Center for Magnetic Materials, National Institute for Materials Science, Tsukuba 305-0047 (Japan); Graduate School of Pure and Applied Sciences, University of Tsukuba, Tsukuba 305-8577 (Japan); Sepehri-Amin, H.; Ohkubo, T. [Elements Strategy Initiative Center for Magnetic Materials, National Institute for Materials Science, Tsukuba 305-0047 (Japan); Hioki, K.; Hattori, A. [Daido Steel Co. Ltd., Nagoya 457-8545 (Japan)

    2014-05-07

    The microstructural evolution of hot-deformed Nd-Fe-B magnets in each stage of hot-deformation process was studied using transmission electron microscopy and three dimensional atom probe (3DAP). The anisotropic growth of initially isotropic grains in rapidly solidified alloy occurs by annealing without pressing. 3DAP analyses showed a higher concentration of rare-earth elements in the intergranular phase parallel to the flat surface of platelet shaped Nd{sub 2}Fe{sub 14}B grains compared to that in the intergranular phase at the side of platelets.

  12. Anisotropic flow fluctuations in hydro-inspired freeze-out model for relativistic heavy ion collisions

    CERN Document Server

    Bravina, L V; Korotkikh, V L; Lokhtin, I P; Malinina, L V; Nazarova, E N; Petrushanko, S V; Snigirev, A M; Zabrodin, E E

    2015-01-01

    The possible mechanisms contributing to anisotropic flow fluctuations in relativistic heavy ion collisions are discussed. The LHC data on event-by-event harmonic flow coefficients measured in PbPb collisions at center-of-mass energy 2.76 TeV per nucleon pair are analyzed and interpreted within the HYDJET++ model. To compare the model results with the experimental data the unfolding procedure is employed. It is shown that HYDJET++ correctly reproduces dynamical fluctuations of elliptic and triangular flows and related to it eccentricity fluctuations of the initial state.

  13. Multi-phase-field study of the effects of anisotropic grain-boundary properties on polycrystalline grain growth

    Science.gov (United States)

    Miyoshi, Eisuke; Takaki, Tomohiro

    2017-09-01

    Numerical studies of the effects of anisotropic (misorientation-dependent) grain-boundary energy and mobility on polycrystalline grain growth have been carried out for decades. However, conclusive knowledge has yet to be obtained even for the simplest two-dimensional case, which is mainly due to limitations in the computational accuracy of the grain-growth models and computer resources that have been employed to date. Our study attempts to address these problems by utilizing a higher-order multi-phase-field (MPF) model, which was developed to accurately simulate grain growth with anisotropic grain-boundary properties. In addition, we also employ general-purpose computing on graphics processing units to accelerate MPF grain-growth simulations. Through a series of simulations of anisotropic grain growth, we succeeded in confirming that both the anisotropies in grain-boundary energy and mobility affect the morphology formed during grain growth. On the other hand, we found the grain growth kinetics in anisotropic systems to follow parabolic law similar to isotropic growth, but only after an initial transient period.

  14. Coefficient adaptive triangulation for strongly anisotropic problems

    Energy Technology Data Exchange (ETDEWEB)

    D`Azevedo, E.F.; Romine, C.H.; Donato, J.M.

    1996-01-01

    Second order elliptic partial differential equations arise in many important applications, including flow through porous media, heat conduction, the distribution of electrical or magnetic potential. The prototype is the Laplace problem, which in discrete form produces a coefficient matrix that is relatively easy to solve in a regular domain. However, the presence of anisotropy produces a matrix whose condition number is increased, making the resulting linear system more difficult to solve. In this work, we take the anisotropy into account in the discretization by mapping each anisotropic region into a ``stretched`` coordinate space in which the anisotropy is removed. The region is then uniformly triangulated, and the resulting triangulation mapped back to the original space. The effect is to generate long slender triangles that are oriented in the direction of ``preferred flow.`` Slender triangles are generally regarded as numerically undesirable since they tend to cause poor conditioning; however, our triangulation has the effect of producing effective isotropy, thus improving the condition number of the resulting coefficient matrix.

  15. Schroedinger covariance states in anisotropic waveguides

    International Nuclear Information System (INIS)

    Angelow, A.; Trifonov, D.

    1995-03-01

    In this paper Squeezed and Covariance States based on Schroedinger inequality and their connection with other nonclassical states are considered for particular case of anisotropic waveguide in LiNiO 3 . Here, the problem of photon creation and generation of squeezed and Schroedinger covariance states in optical waveguides is solved in two steps: 1. Quantization of electromagnetic field is provided in the presence of dielectric waveguide using normal-mode expansion. The photon creation and annihilation operators are introduced, expanding the solution A-vector(r-vector,t) in a series in terms of the Sturm - Liouville mode-functions. 2. In terms of these operators the Hamiltonian of the field in a nonlinear waveguide is derived. For such Hamiltonian we construct the covariance states as stable (with nonzero covariance), which minimize the Schroedinger uncertainty relation. The evolutions of the three second momenta of q-circumflex j and p-circumflex j are calculated. For this Hamiltonian all three momenta are expressed in terms of one real parameters s only. It is found out how covariance, via this parameter s, depends on the waveguide profile n(x,y), on the mode-distributions u-vector j (x,y), and on the waveguide phase mismatching Δβ. (author). 37 refs

  16. Anisotropic Charged Fluid Sphere in Isotropic Coordinates

    Directory of Open Access Journals (Sweden)

    Neeraj Pant

    2014-01-01

    Full Text Available We have presented a class of charged superdense star models, starting with a static spherically symmetric metric in isotropic coordinates for anisotropic fluid by considering Hajj-Boutros-(1986 type metric potential and a specific choice of electrical intensity E and anisotropy factor Δ which involve charge parameter K and anisotropy parameter α. The solution is well behaved for all the values of Schwarzschild compactness parameter u lying in the range 0

  17. Numerical calculation of spatially variant anisotropic metamaterials

    Science.gov (United States)

    Gulib, Asad Ullah Hil

    3D printing, or additive manufacturing, is rapidly evolving into a mainstream manufacturing technology that is creating new opportunities for electromagnetics and circuits. 3D printing permits circuits to fully utilize the third dimension allowing more functions in the same amount of space and allows the devices to have arbitrary form factors. 3D printing is letting us discover new physics that is not possible in standard 2D circuits and devices. However, evolving electromagnetics and circuits into three dimensions introduces some serious problems like thermal management, interference, and mutual coupling between the components which degrades performance and hurts signal integrity. Metamaterials are engineered composites that exhibit extreme electromagnetic properties and allow extraordinary control over electromagnetic fields. The EM Lab is developing spatially-variant anisotropic metamaterials (SVAMs) as a solution to mitigate mutual coupling between components. The concept of SVAMs is to electrically stretch the space between components to reduce mutual coupling. To do this, alternating layers of different dielectric must bisect adjacent components. However, the overall dielectric fill must also conform around dozens of electrical components and be smooth, continuous, and defect free. The research described here is the first prototype of an algorithm which generates a SVAM infill between all of the electrical components of a circuit in order to reduce the mutual coupling.

  18. P wave anisotropic tomography of the Alps

    Science.gov (United States)

    Hua, Yuanyuan; Zhao, Dapeng; Xu, Yixian

    2017-06-01

    The first tomographic images of P wave azimuthal and radial anisotropies in the crust and upper mantle beneath the Alps are determined by joint inversions of arrival time data of local earthquakes and teleseismic events. Our results show the south dipping European plate with a high-velocity (high-V) anomaly beneath the western central Alps and the north dipping Adriatic plate with a high-V anomaly beneath the Eastern Alps, indicating that the subduction polarity changes along the strike of the Alps. The P wave azimuthal anisotropy is characterized by mountain chain-parallel fast-velocity directions (FVDs) in the western central Alps and NE-SW FVDs in the Eastern Alps, which may be caused by mantle flow induced by the slab subductions. Our results reveal a negative radial anisotropy (i.e., Vph Vph > Vpv) in the low-velocity mantle wedge, which may reflect the subvertical plate subduction and its induced mantle flow. The results of anisotropic tomography provide important new information on the complex mantle structure and dynamics of the Alps and adjacent regions.

  19. Anisotropic reflectance characteristics of natural Earth surfaces.

    Science.gov (United States)

    Brennan, B; Bandeen, W R

    1970-02-01

    The patterns of reflection of solar radiation from cloud, water, and land surfaces were measured with an aircraft-borne medium resolution radiometer. Reflectances in the 0.2-4.0-micro and 0.55-0.85-micro portions of the electromagnetic spectrum were investigated. Results indicate that the reflectance characteristics of most of the surface types measured are anisotropic. The anisotropy is dependent on the type of surface and the angles of incidence and reflection. In general, the anisotropy increases with increasing solar zenith angle. Clouds and forests show similar reflectance patterns, with forward and backward scattering peaks. Ocean surfaces yield a pattern similar to those of the clouds and forests but with an additional peak which is associated with sun glitter. Reflectances measured in the 0.2-4.0-micro band are generally lower than those in the 0.55-0.85-micro band under cloudy conditions. Anisotropy and spectral bandwidth should be accounted for when computing the albedo of the earth from narrow field-of-view measurements from satellites; otherwise, large errors may be expected to occur.

  20. Methylselenium and Prostate Cancer Apoptosis

    National Research Council Canada - National Science Library

    Lu, Junxuan

    2007-01-01

    The purpose of this research is to gain a better understanding of the biochemical pathways and molecular targets for the selective induction of apoptosis signaling and execution of prostate cancer (PCa...

  1. Methylselenium and Prostate Cancer Apoptosis

    National Research Council Canada - National Science Library

    Lu, Junxuan

    2005-01-01

    The purpose of this research is to gain a better understanding of the biochemical pathways and molecular targets for the selective induction of apoptosis signaling and execution of prostate cancer (PCa...

  2. Methylselenium and Prostate Cancer Apoptosis

    National Research Council Canada - National Science Library

    Lu, Junxuan

    2006-01-01

    The purpose of this research is to gain a better understanding of the biochemical pathways and molecular targets for the selective induction of apoptosis signaling and execution of prostate cancer (PCa...

  3. Methylselenium and Prostate Cancer Apoptosis

    National Research Council Canada - National Science Library

    Lu, Junxuan

    2004-01-01

    The purpose of this research is to gain a better understanding of the biochemical pathways and molecular targets for the selective induction of apoptosis signaling and execution of PCa cells by methyl selenium (Se)/selenol...

  4. Methylselenium and Prostate Cancer Apoptosis

    National Research Council Canada - National Science Library

    Lu, Junxuan

    2008-01-01

    The purpose of this research is to gain a better understanding of the biochemical pathways and molecular targets for the selective induction of apoptosis signaling and execution of prostate cancer (PCa...

  5. Methylselenium and Prostate Cancer Apoptosis

    National Research Council Canada - National Science Library

    Lu, Junxuan

    2003-01-01

    The purpose of this research is to gain a better understanding of the biochemical pathways and molecular targets for the selective induction of apoptosis signaling and execution of PCa cells by methyl selenium (Se...

  6. Application of the anisotropic phase-field crystal model to investigate the lattice systems of different anisotropic parameters and orientations

    Science.gov (United States)

    Kundin, Julia; Ajmal Choudhary, Muhammad

    2017-07-01

    In this article, we present the recent advances in the development of the anisotropic phase-field crystal (APFC) model. These advances are important in basic researches for multiferroic and thermoelectric materials with anisotropic crystal lattices and in thin-film applications. We start by providing a general description of the model derived in our previous studies based on the crystal symmetry and the microscopic dynamical density functional theory for anisotropic interactions and show that there exist only two possible degrees of freedom for the anisotropic lattices which are described by two independent parameters. New findings concerning the applications of the APFC model for the estimation of the elastic modules of anisotropic systems including sheared and stretched lattices as well as for the investigation of the heterogeneous thin film growth are described. The simulation results demonstrate the strong dependency of the misfit dislocation formation during the film growth on the anisotropy and reveal the asymmetric behavior in the cases of positive and negative misfits. We also present the development of the amplitude representation for the full APFC model of two orientation variants and show the relationship between the wave vectors and the base angles of the anisotropic lattices.

  7. PURCELL EFFECT IN EXTREMELY ANISOTROPIC ELLIPTIC METAMATERIALS

    Directory of Open Access Journals (Sweden)

    Alexander V. Chebykin

    2014-11-01

    Full Text Available The paper deals with theoretical demonstration of Purcell effect in extremely anisotropic metamaterials with elliptical isofrequency surface. This effect is free from association with divergence in density of states unlike the case of hyperbolic metamaterials. It is shown that a large Purcell factor can be observed without excitation of modes with large wave vectors in one direction, and the component of the wave vector normal to the layers is less than k0. For these materials the possibility is given for increasing of the power radiated in the medium, as well as the power radiated from material into free space across the medium border situated transversely to the layers. We have investigated isofrequency contours and the dependence of Purcell factor from the frequency for infinite layered metamaterial structure. In the visible light range strong spatial dispersion gives no possibility to obtain enhancement of spontaneous emission in metamaterial with unit cell which consists of two layers. This effect can be achieved in periodic metal-dielectric layered nanostructures with a unit cell containing two different metallic layers and two dielectric ones. Analysis of the dependences for Purcell factor from the frequency shows that the spontaneous emission is enhanced by a factor of ten or more only for dipole orientation along metamaterial layers, but in the case of the transverse orientation radiation can be enhanced only 2-3 times at most. The results can be used to create a new type of metamaterials with elliptical isofrequency contours, providing a more efficient light emission in the far field.

  8. Study of progesterone mechanisms in radio-induced apoptosis prevention

    International Nuclear Information System (INIS)

    Vares, G.

    2004-10-01

    The purpose of this work was to study the modulation of radiation-induced cell death of human mammary tumoral cells by progesterone. On the one hand, we observed that progesterone protects cells against radiation-induced apoptosis and increases the proportion of surviving and proliferating damaged cells. On the other hand, a transcriptome analysis was undertaken in irradiated cells treated by progesterone, using DNA micro-arrays. This let us highlight several transcriptional dis-regulations that are likely to explain the protective effect of the hormone; in particular, we showed that progesterone regulates the expression of genes implicated in apoptosis signaling by death receptors. Knowing the crucial role of hormonal control and of apoptosis regulation in breast cancer initiation, our results may help to achieve a better understanding of the implication of progesterone in mammary carcinogenesis. (author)

  9. Caspase-12 is involved in stretch-induced apoptosis mediated endoplasmic reticulum stress.

    Science.gov (United States)

    Zhang, Qiang; Liu, Jianing; Chen, Shulan; Liu, Jing; Liu, Lijuan; Liu, Guirong; Wang, Fang; Jiang, Wenxin; Zhang, Caixia; Wang, Shuangyu; Yuan, Xiao

    2016-04-01

    It is well recognized that mandibular growth, which is caused by a variety of functional appliances, is considered to be the result of both neuromuscular and skeletal adaptations. Accumulating evidence has demonstrated that apoptosis plays an important role in the adaptation of skeletal muscle function. However, the underlying mechanism of apoptosis that is induced by stretch continues to be incompletely understood. Endoplasmic reticulum stress (ERS), a newly defined signaling pathway, initiates apoptosis. This study seeks to determine if caspase-12 is involved in stretch-induced apoptosis mediated endoplasmic reticulum stress in myoblast and its underlying mechanism. Apoptosis was assessed by Hochest staining, DAPI staining and annexin V binding and PI staining. ER chaperones, such as GRP78, CHOP and caspase-12, were determined by reverse transcription polymerase chain reaction (RT-PCR) and Western blot. Furthermore, caspase-12 inhibitor was used to value the mechanism of the caspase-12 pathway. Apoptosis of myoblast, which is subjected to cyclic stretch, was observed in a time-dependent manner. We found that GRP78 mRNA and protein were significantly increased and CHOP and caspase-12 were activated in myoblast that was exposed to cyclic stretch. Caspase-12 inhibition reduced stretch-induced apoptosis, and caspase-12 activated caspase-3 to induce apoptosis. We concluded that caspase-12 played an important role in stretch-induced apoptosis that is associated by endoplasmic reticulum stress by activating caspase-3.

  10. Thymocyte apoptosis induced by p53-dependent and independent pathways

    Energy Technology Data Exchange (ETDEWEB)

    Clarke, A.R.; Purdie, C.A.; Harrison, D.J.; Morris, R.G.; Bird, C.C.; Hooper, M.L.; Wyllie, A.H. (Edinburgh Univ. Medical School (United Kingdom). Dept. of Pathology)

    1993-04-29

    The authors studied the dependence of apoptosis on p53 expression in cells from the thymus cortex. Short-term thymocyte cultures were prepared from mice constitutively heterozygous or homozygous for a deletion in the p53 gene introduced into the germ line after gene targeting. Wild-type thymocytes readily undergo apoptosis after treatment with ionizing radiation, the glucocorticoid methylprednisolone, or etoposide (an inhibitor of topoisomerase II), or after Ca[sup 2+]-dependent activation by phorbol ester and a calcium ionophore. In contrast, homozygous null p53 thymocytes are resistant to induction of apoptosis by radiation or etoposide, but retain normal sensitivity to glucocorticoid and calcium. The time- dependent apoptosis that occurs in untreated cultures is unaffected by p53 status. Cells heterozygous for p53 deletion are partially resistant to radiation and etoposide. Results show that p53 exerts a significant and dose-dependent effect in the initiation of apoptosis, but only when it is induced by agents that cause DNA-strand breakage. (Author).

  11. 2D seismic reflection tomography in strongly anisotropic media

    Science.gov (United States)

    Huang, Guangnan; Zhou, Bing; Li, Hongxi; Zhang, Hua; Li, Zelin

    2014-12-01

    Seismic traveltime tomography is an effective method to reconstruct underground anisotropic parameters. Currently, most anisotropic tomographic methods were developed under the assumption of weak anisotropy. The tomographic method proposed here can be implemented for imaging subsurface targets in strongly anisotropic media with a known tilted symmetry axis, since the adopted ray tracing method is suitable for anisotropic media with arbitrary degree. There are three kinds of reflection waves (qP, qSV and qSH waves) that were separately used to invert the blocky abnormal body model. The reflection traveltime tomographiy is developed here because a surface observation system is the most economical and practical way compared with crosswell and VSP. The numerical examples show that the traveltimes of qP reflection wave have inverted parameters {{c}11},{{c}13},{{c}33} \\text{and} {{c}44} successfully. Traveltimes of qSV reflection wave have inverted parameters {{c}11},{{c}33} \\text{and} {{c}44} successfully, with the exception of the {{c}13}, since it is less sensitive than other parameters. Traveltimes of qSH reflection wave also have inverted parameters {{c}44} \\text{and} {{c}66} successfully. In addition, we find that the velocity sensitivity functions (derivatives of phase velocity with respect to elastic moduli parameters) and raypath illuminating angles have a great influence on the qualities of tomograms according to the inversion of theoretical models. Finally, the numerical examples confirm that the reflection traveltime tomography can be applied to invert strongly anisotropic models.

  12. Formulation of cross-anisotropic failure criterion for soils

    Directory of Open Access Journals (Sweden)

    Yi-fei Sun

    2013-10-01

    Full Text Available Inherently anisotropic soil fabric has a considerable influence on soil strength. To model this kind of inherent anisotropy, a three-dimensional anisotropic failure criterion was proposed, employing a scalar-valued anisotropic variable and a modified general threedimensional isotropic failure criterion. The scalar-valued anisotropic variable in all sectors of the deviatoric plane was defined by correlating a normalized stress tensor with a normalized fabric tensor. Detailed comparison between the available experimental data and the corresponding model predictions in the deviatoric plane was conducted. The proposed failure criterion was shown to well predict the failure behavior in all sectors, especially in sector II with the Lode angle ranging between 60° and 120°, where the prediction was almost in accordance with test data. However, it was also observed that the proposed criterion overestimated the strength of dense Santa Monica Beach sand in sector III where the intermediate principal stress ratio b varied from approximately 0.2 to 0.8, and slightly underestimated the strength when b was between approximately 0.8 and 1. The difference between the model predictions and experimental data was due to the occurrence of shear bending, which might reduce the measured strength. Therefore, the proposed anisotropic failure criterion has a strong ability to characterize the failure behavior of various soils and potentially allows a better description of the influence of the loading direction with respect to the soil fabric.

  13. Placental apoptosis in recurrent miscarriage

    Directory of Open Access Journals (Sweden)

    Tarek A. Atia

    2017-09-01

    Full Text Available Apoptosis is an interactive and dynamic biological process involved in all phases of embryogenesis. We aimed to study the effect of placental apoptosis on recurrent miscarriage (RM. Placental tissue samples were collected from 40 women with RM (study group and 30 women with sporadic spontaneous abortion (control group. Samples were prepared and stained immunohistochemically with markers for both the apoptotic protein (p53 and anti-apoptotic Bcl-2 antibodies. Our results showed that expression of the apoptotic (p53 protein was significantly increased in the placental tissues of the RM group (p = 0.003. By contrast, the expression of anti-apoptotic (Bcl-2 antibodies was significantly increased in the placental tissues of the control group (p = 0.025. We concluded that placental apoptosis plays a crucial role in pregnancy continuation. However, increased p53 expression in placental tissue in early pregnancy could negatively affect pregnancy continuation.

  14. 3-D waveform tomography sensitivity kernels for anisotropic media

    KAUST Repository

    Djebbi, Ramzi

    2014-01-01

    The complications in anisotropic multi-parameter inversion lie in the trade-off between the different anisotropy parameters. We compute the tomographic waveform sensitivity kernels for a VTI acoustic medium perturbation as a tool to investigate this ambiguity between the different parameters. We use dynamic ray tracing to efficiently handle the expensive computational cost for 3-D anisotropic models. Ray tracing provides also the ray direction information necessary for conditioning the sensitivity kernels to handle anisotropy. The NMO velocity and η parameter kernels showed a maximum sensitivity for diving waves which results in a relevant choice of those parameters in wave equation tomography. The δ parameter kernel showed zero sensitivity; therefore it can serve as a secondary parameter to fit the amplitude in the acoustic anisotropic inversion. Considering the limited penetration depth of diving waves, migration velocity analysis based kernels are introduced to fix the depth ambiguity with reflections and compute sensitivity maps in the deeper parts of the model.

  15. Anomalously large anisotropic magnetoresistance in a perovskite manganite.

    Science.gov (United States)

    Li, Run-Wei; Wang, Huabing; Wang, Xuewen; Yu, X Z; Matsui, Y; Cheng, Zhao-Hua; Shen, Bao-Gen; Plummer, E Ward; Zhang, Jiandi

    2009-08-25

    The signature of correlated electron materials (CEMs) is the coupling between spin, charge, orbital and lattice resulting in exotic functionality. This complexity is directly responsible for their tunability. We demonstrate here that the broken symmetry, through cubic to orthorhombic distortion in the lattice structure in a prototype manganite single crystal, La(0.69)Ca(0.31)MnO(3), leads to an anisotropic magneto-elastic response to an external field, and consequently to remarkable magneto-transport behavior. An anomalous anisotropic magnetoresistance (AMR) effect occurs close to the metal-insulator transition (MIT) in the system, showing a direct correlation with the anisotropic field-tuned MIT in the system and can be understood by means of a simple phenomenological model. A small crystalline anisotropy stimulates a "colossal" AMR near the MIT phase boundary of the system, thus revealing the intimate interplay between magneto- and electronic-crystalline couplings.

  16. Electromagnetic waves in uniaxial anisotropic chiral waveguides in magnetized plasma

    Science.gov (United States)

    Ghaffar, A.; Alkanhal, Majeed A. S.

    2015-07-01

    The characteristics of guided modes in circular waveguides of a uniaxial anisotropic chiral core and a cladding filled with anisotropic plasma are presented. The cladding region is assumed to be infinitely extended with an external applied magnetic field oriented along the direction of propagation in the waveguide. The characteristics equation for the modes in this waveguide are obtained. The variations of the propagation properties with the plasma parameters, chiral parameters, and the cyclotron frequency of plasma have been investigated. Particularly, the effects of the chirality and the cyclotron frequency of plasma on the magnitude and orientation of the energy flux of the guided modes for three kinds of uniaxial anisotropic chiral media have been numerically investigated. Comparisons of the computed results of the presented formulations with published results for some special cases confirm the accuracy of the presented analyses.

  17. Detection of the default mode network by an anisotropic analysis

    Science.gov (United States)

    Forero, Aura; Romero, Eduardo

    2017-11-01

    This document presents a proposal devoted to improve the detection of the default mode network (DMN) in resting state functional magnetic resonance imaging in noisy conditions caused by head movement. The proposed approach is inspired by the hierarchical treatment of information, in particular at the level of the brain basal ganglia. Essentially, the fact that information must be selected and reduced suggests propagation of information in the Central Nervous System (CNS) is anisotropic. Under this hypothesis, the reconstruction of information of activation should follow an anisotropic pattern. In this work, an anisotropic filter is used to recover the DMN that is perturbed by simulated motion artifacts. Results obtained show this approach outperforms the state-of-the-art methods by 5.93% PSNR.

  18. Anisotropic spreading of liquid metal on a rough intermetallic surface

    Directory of Open Access Journals (Sweden)

    Liu Wen

    2011-01-01

    Full Text Available An anisotropic wicking of molten Sn-Pb solder over an intermetallic rough surface has been studied. The phenomenon features preferential spreading and forming of an elliptical spread domain. A theoretically formulated model was established to predict the ratio of the wicking distance along the long axis (rx to that along the short axis (ry of the final wicking pattern. The phenomenon was simultaneously experimentally observed and recorded with a hotstage microscopy technique. The anisotropic wicking is established to be caused by a non-uniform topography of surface micro structures as opposed to an isotropic wicking on an intermetallic surface with uniformly distributed surface micro features. The relative deviation between the theoretically predicted rx/ry ratio and the corresponding average experimental value is 5%. Hence, the small margin of error confirms the validity of the proposed theoretical model of anisotropic wicking.

  19. Investigation of anisotropic scattering for optical tomography in biological tissues

    International Nuclear Information System (INIS)

    Mercimek, M.; Yildirim, H.; Geckinli, M.; Aydin, M.; Aydin, E. D.

    2009-01-01

    Photons with wavelengths in near infrared region are used in optical tomography. Radiation transport theory should be preferred instead of diffusion theory for numerical modelling of photon migration in biological tissues, where diffusion theory is invalid. For example, diffusion theory is not sufficient in the regions of close to boundaries, sources or sinks and highly absorbing or void-like media. Also anisotropic scattering must be considered in the numerical models since scattering is generally highly anisotropic in biological tissues. In addition to the absorption and scattering coefficients, a suitable phase function must be known in anisotropic scattering study. Here we have compared scattering phase functions for anisotropy. Then we have calculated Legendre moments which are necessary for the implementation of anisotropy factors into the transport code, PARTISN. Discrete ordinates method (SN) has been used in the transport calculations. We have obtained solutions first a homogeneous and then heterogeneous medium.

  20. Thermodynamics and instabilities of a strongly coupled anisotropic plasma

    Science.gov (United States)

    Mateos, David; Trancanelli, Diego

    2011-07-01

    We extend our analysis of a IIB supergravity solution dual to a spatially anisotropic finite-temperature mathcal{N} = 4 super Yang-Mills plasma. The solution is static, possesses an anisotropic horizon, and is completely regular. The full geometry can be viewed as a renormalization group flow from an AdS geometry in the ultraviolet to a Lifshitz-like geometry in the infrared. The anisotropy can be equivalently understood as resulting from a position-dependent θ-term or from a non-zero number density of dissolved D7-branes. The holographic stress tensor is conserved and anisotropic. The presence of a conformal anomaly plays an important role in the thermodynamics. The phase diagram exhibits homogeneous and inhomogeneous (i.e. mixed) phases. In some regions the homogeneous phase displays instabilities reminiscent of those of weakly coupled plasmas. We comment on similarities with QCD at finite baryon density and with the phenomenon of cavitation.

  1. Anomalously large anisotropic magnetoresistance in a perovskite manganite

    Science.gov (United States)

    Li, Run-Wei; Wang, Huabing; Wang, Xuewen; Yu, X. Z.; Matsui, Y.; Cheng, Zhao-Hua; Shen, Bao-Gen; Plummer, E. Ward; Zhang, Jiandi

    2009-01-01

    The signature of correlated electron materials (CEMs) is the coupling between spin, charge, orbital and lattice resulting in exotic functionality. This complexity is directly responsible for their tunability. We demonstrate here that the broken symmetry, through cubic to orthorhombic distortion in the lattice structure in a prototype manganite single crystal, La0.69Ca0.31MnO3, leads to an anisotropic magneto-elastic response to an external field, and consequently to remarkable magneto-transport behavior. An anomalous anisotropic magnetoresistance (AMR) effect occurs close to the metal-insulator transition (MIT) in the system, showing a direct correlation with the anisotropic field-tuned MIT in the system and can be understood by means of a simple phenomenological model. A small crystalline anisotropy stimulates a “colossal” AMR near the MIT phase boundary of the system, thus revealing the intimate interplay between magneto- and electronic-crystalline couplings. PMID:19706504

  2. Nonlinear, anisotropic, and giant photoconductivity in intrinsic and doped graphene

    Science.gov (United States)

    Singh, Ashutosh; Ghosh, Saikat; Agarwal, Amit

    2018-01-01

    We present a framework to calculate the anisotropic and nonlinear photoconductivity for two band systems with application to graphene. In contrast to the usual perturbative (second order in the optical field strength) techniques, we calculate photoconductivity to all orders in the optical field strength. In particular, for graphene, we find the photoresponse to be giant (at large optical field strengths) and anisotropic. The anisotropic photoresponse in graphene is correlated with polarization of the incident field, with the response being similar to that of a half-wave plate. We predict that the anisotropy in the simultaneous measurement of longitudinal (σx x) and transverse (σy x) photoconductivity, with four probes, offers a unique experimental signature of the photovoltaic response, distinguishing it from the thermal-Seebeck and bolometric effects in photoresponse.

  3. Modeling of charged anisotropic compact stars in general relativity

    Energy Technology Data Exchange (ETDEWEB)

    Dayanandan, Baiju; Maurya, S.K.; T, Smitha T. [University of Nizwa, Department of Mathematical and Physical Sciences, College of Arts and Science, Nizwa (Oman)

    2017-06-15

    A charged compact star model has been determined for anisotropic fluid distribution. We have solved the Einstein-Maxwell field equations to construct the charged compact star model by using the radial pressure, the metric function e{sup λ} and the electric charge function. The generic charged anisotropic solution is verified by exploring different physical conditions like causality condition, mass-radius relation and stability of the solution (via the adiabatic index, TOV equations and the Herrera cracking concept). It is observed that the present charged anisotropic compact star model is compatible with the star PSR 1937+21. Moreover, we also presented the EOS ρ = f(p) for the present charged compact star model. (orig.)

  4. Self-force on dislocation segments in anisotropic crystals

    International Nuclear Information System (INIS)

    Fitzgerald, S P; Aubry, S

    2010-01-01

    A dislocation segment in a crystal experiences a 'self-force', by virtue of the orientation dependence of its elastic energy. If the crystal is elastically isotropic, this force is manifested as a couple acting to rotate the segment toward the lower energy of the pure screw orientation (i.e. acting to align the dislocation line with its Burgers vector). If the crystal is anisotropic, there are additional contributions to the couple, arising from the more complex energy landscape of the lattice itself. These effects can strongly influence the dynamic evolution of dislocation networks, and via their governing role in dislocation multiplication phenomena, control plastic flow in metals. In this paper we develop a model for dislocation self-forces in a general anisotropic crystal, and briefly consider the technologically important example of α-iron, which becomes increasingly anisotropic as the temperature approaches that of the α-γ phase transition at 912 0 C.

  5. Lower critical field of an anisotropic type-II superconductor

    International Nuclear Information System (INIS)

    Klemm, R.A.; Clem, J.R.

    1980-01-01

    We consider the Ginzburg-Landau free energy of the anisotropic mass form in the presence of a magnetic field of arbitrary fixed direction. It is shown that the free energy may be transformed into the isotropic Ginsburg-Landau form with a kappa that depends upon the direction of the magnetic induction B relative to the crystal lattice. The lower critical field H/sub c/1 is then found for arbitrary direction of B. For highly anisotropic crystals the angular dependence of H/sub c/1 can exhibit a discontinuity or a cusp. The special case of a crystal with uniaxial symmetry is considered in detail

  6. Anisotropic extension of Finch and Skea stellar model

    Science.gov (United States)

    Sharma, Ranjan; Das, Shyam; Thirukkanesh, S.

    2017-12-01

    In this paper, the spacetime geometry of Finch and Skea [Class. Quantum Gravity 6:467, 1989] has been utilized to obtain closed-form solutions for a spherically symmetric anisotropic matter distribution. By examining its physical admissibility, we have shown that the class of solutions can be used as viable models for observed pulsars. In particular, a specific class of solutions can be used as an `anisotropic switch' to examine the impact of anisotropy on the gross physical properties of a stellar configuration. Accordingly, the mass-radius relationship has been analyzed.

  7. Anisotropic Liquid Microcapsules from Biomimetic Self-Folding Polymer Films.

    Science.gov (United States)

    Zakharchenko, Svetlana; Ionov, Leonid

    2015-06-17

    We demonstrated a novel approach for the fabrication of anisotropic capsules with liquid content using biomimetic self-folding thermoresponsive polymer films. The behavior of self-folding films is very similar to actuation in plants, where nonhomogenous swelling results in complex movements such as twisting, bending, or folding. This approach allows the design of anisotropic liquid capsules with rodlike and dumbbell-like morphologies. We found that these capsules are able to assemble into different complex structures, such as nematic-like one and 3D network depending on their morphology.

  8. Remarks on anisotropy of inertia in an anisotropic cosmos

    Science.gov (United States)

    Treder, Hans-Juergen

    1992-03-01

    The astronomical and physical meaning of the anisotropy of inertia is analyzed with respect to the relativity of inertia and anisotropic distributions of gravitating matter in the universe. Attention is given to the theoretical compatibility of the anisotropy of inertial masses with Mach's principle of the relativity of inertia and the Mach-Einstein doctrine of general relativity. Mach's principle does not imply anisotropy of inertial masses in an anisotropic universe, and the isotropy of cosmological mass is supported by the Mach-Einstein theories.

  9. Anisotropic behavior of quantum transport in graphene superlattices

    DEFF Research Database (Denmark)

    Pedersen, Jesper Goor; Cummings, Aron W.; Roche, Stephan

    2014-01-01

    We report on the possibility to generate highly anisotropic quantum conductivity in disordered graphene-based superlattices. Our quantum simulations, based on an efficient real-space implementation of the Kubo-Greenwood formula, show that in disordered graphene superlattices the strength of multi...... orders of magnitude, and suggesting the possibility of building graphene electronic circuits based on the unique properties of chiral massless Dirac fermions in graphene.......We report on the possibility to generate highly anisotropic quantum conductivity in disordered graphene-based superlattices. Our quantum simulations, based on an efficient real-space implementation of the Kubo-Greenwood formula, show that in disordered graphene superlattices the strength...

  10. All spherically symmetric charged anisotropic solutions for compact stars

    Energy Technology Data Exchange (ETDEWEB)

    Maurya, S.K. [University of Nizwa, Department of Mathematical and Physical Sciences, College of Arts and Science, Nizwa (Oman); Gupta, Y.K. [Raj Kumar Goel Institute of Technology, Department of Mathematics, Ghaziabad, UP (India); Ray, Saibal [Government College of Engineering and Ceramic Technology, Department of Physics, Kolkata, West Bengal (India)

    2017-06-15

    In the present paper we develop an algorithm for all spherically symmetric anisotropic charged fluid distributions. Considering a new source function ν(r) we find a set of solutions which is physically well behaved and represents compact stellar models. A detailed study specifically shows that the models actually correspond to strange stars in terms of their mass and radius. In this connection we investigate several physical properties like energy conditions, stability, mass-radius ratio, electric charge content, anisotropic nature and surface redshift through graphical plots and mathematical calculations. All the features from these studies are in excellent agreement with the already available evidence in theory as well as observations. (orig.)

  11. Correlation theory of crystal field and anisotropic exchange effects

    DEFF Research Database (Denmark)

    Lindgård, Per-Anker

    1985-01-01

    A general theory for including correlation effects in static and dynamic properties is presented in terms of Raccah or Stevens operators. It is explicitly developed for general crystal fields and anisotropic interactions and systems with several sublattices, like the rare earth compounds. The the......A general theory for including correlation effects in static and dynamic properties is presented in terms of Raccah or Stevens operators. It is explicitly developed for general crystal fields and anisotropic interactions and systems with several sublattices, like the rare earth compounds...... on the susceptibility, the first and second moment frequencies and the line shape are calculated self-consistently....

  12. Tunable waveguide bends with graphene-based anisotropic metamaterials

    KAUST Repository

    Chen, Zhao-xian

    2016-01-15

    We design tunable waveguide bends filled with graphene-based anisotropic metamaterials to achieve a nearly perfect bending effect. The anisotropic properties of the metamaterials can be described by the effective medium theory. The nearly perfect bending effect is demonstrated by finite element simulations of various structures with different bending curvatures and shapes. This effect is attributed to zero effective permittivity along the direction of propagation and matched effective impedance at the interfaces between the bending part and the dielectric waveguides. We envisage that the design will be applicable in the far-infrared and terahertz frequency ranges owing to the tunable dielectric responses of graphene.

  13. Integral superposition of paraxial Gaussian beams in inhomogeneous anisotropic layered structures in Cartesian coordinates

    Czech Academy of Sciences Publication Activity Database

    Červený, V.; Pšenčík, Ivan

    2015-01-01

    Roč. 25, - (2015), s. 109-155 ISSN 2336-3827 Institutional support: RVO:67985530 Keywords : integral superposition of paraxial Gaussian beams * inhomogeneous anisotropic media * S waves in weakly anisotropic media Subject RIV: DC - Siesmology, Volcanology, Earth Structure

  14. Anisotropic sensitivity of RDX and HMX from compressive shear reactive dynamics study

    Science.gov (United States)

    Zhou, Tingting; An, Qi; Liu, Yi; Zybin, Sergey V.; Goddard, William A., III; Materials Process Simulation Center, Caltech Team

    2011-06-01

    The ReaxFF reactive force field was applied to study the mechanical and chemical behavior of RDX and HMX under combined compression and shear load. We use it to predict the anisotropic shock sensitivity of RDX and HMX single crystals. After compressed uniaxially along different shock directions, several preferable slip systems are chosen based on the maximum resolved shear stress. The pure shear deformation is applied at constant rate on these slip systems to relax the mechanical stresses until the crystal becomes amorphous. We find that the shear on a slip system with larger steric hindrance between molecules leads to larger shear stress overshoot and faster temperature increase resulting in early bond-breaking processes and initiation of chemical reactions. Our simulations confirm the effect of steric hindrance to shear on shock anisotropy of sensitivity and capture the thermochemical processes dominating the phenomena of shear-induced chemical initiation of shock- compressed explosives.

  15. Nonequilibrium current-carrying steady states in the anisotropic X Y spin chain

    Science.gov (United States)

    Lancaster, Jarrett L.

    2016-05-01

    Out-of-equilibrium behavior is explored in the one-dimensional anisotropic X Y model. Initially preparing the system in the isotropic X X model with a linearly varying magnetic field to create a domain-wall magnetization profile, dynamics is generated by rapidly changing the exchange interaction anisotropy and external magnetic field. Relaxation to a nonequilibrium steady state is studied analytically at the critical transverse Ising point, where correlation functions may be computed in closed form. For arbitrary values of anisotropy and external field, an effective generalized Gibbs' ensemble is shown to accurately describe observables in the long-time limit. Additionally, we find spatial oscillations in the exponentially decaying, transverse spin-spin correlation functions with wavelength set by the magnetization jump across the initial domain wall. This wavelength depends only weakly on anisotropy and magnetic field in contrast to the current, which is highly dependent on these parameters.

  16. Selected aspects of apoptosis in psoriasis

    Directory of Open Access Journals (Sweden)

    Hanna Myśliwiec

    2017-03-01

    Full Text Available Apoptosis is a physiological mechanism of programmed cell death, in contrast to necrosis, without eliciting an inflammatory response. It plays the key role in the functioning of different tissues and organs. The balance between proliferation and apoptosis of keratinocytes is important for epidermal maintenance of homeostasis. Dysfunctional apoptosis plays an important role in the development of several skin disorders. Diseases with an increase of apoptosis are usually acute, while those with inhibited apoptosis tend to be chronic. Psoriasis is an immune-mediated chronic inflammatory skin disease. It is characterized by keratinocyte hyperproliferation and abnormal differentiation. Psoriatic keratinocytes are resistant to apoptosis and this phenomenon can be the key event in psoriatic hyperplasia. Apoptosis disturbances can also affect immune cells involved in the pathogenesis of psoriasis. In this review, we describe the basic concept of apoptosis and its relevance in psoriatic pathogenesis.

  17. A Morphing framework to couple non-local and local anisotropic continua

    KAUST Repository

    Azdoud, Yan

    2013-05-01

    In this article, we develop a method to couple anisotropic local continua with anisotropic non-local continua with central long-range forces. First, we describe anisotropic non-local models based on spherical harmonic descriptions. We then derive compatible classic continuum models. Finally, we apply the morphing method to these anisotropic non-local models and present three-dimensional numerical examples to validate the efficiency of the technique. © 2013 Elsevier Ltd. All rights reserved.

  18. Apoptosis detection in histological sections

    Czech Academy of Sciences Publication Activity Database

    Matalová, Eva; Dubská, Lenka; Míšek, Ivan

    2003-01-01

    Roč. 72, č. 7 (2003), s. 18-19 ISSN 0001-7213. [Congress of the European Association of Veterinary Anatomists/24./. 21.07.2002-25.07.2002, Brno] R&D Projects: GA ČR GP204/02/P112 Institutional research plan: CEZ:AV0Z5045916 Keywords : apoptosis Subject RIV: FF - HEENT, Dentistry

  19. Radiation-induced apoptosis of lymphocytes in peripheral blood

    International Nuclear Information System (INIS)

    Oh, Yoon Kyeong; Lee, Tae Bum; Nam, Taek Keun; Kee, Keun Hong; Choi, Cheol Hee

    2003-01-01

    This study quantitatively evaluated the apoptosis in human peripheral blood lymphocytes using flow cytometry, and investigated the possibility of using this method, with a small amount of blood, and the time and dose dependence of radiation-induced apoptosis. Peripheral blood lymphocytes were isolated from the heparinized venous blood of 11 healthy volunteers, 8 men and 3 women, with each 10 ml of blood being divided into 15 samples. The blood lymphocytes were irradiated using a linear accelerator at a dose rate of 2.4 Gy/min, to deliver doses of 0.5, 1, 2 and 5 Gy. The control samples, and irradiated cells, were maintained in culture medium for 24, 48 and 72 hours following the irradiation. The number of apoptotic cells after the in vitro X-irradiation was measured by flow cytometry after incubation periods of 24, 48 and 72 hours. We also observed the apoptotic cells using a DNA fragmentation assay and electron microscopy. The rate of spontaneous apoptosis increased in relation to the time interval following irradiation (1.761±0.161, 3.563±0.564, 11.098±2.849, at 24, 48, and 72 hours). The apoptotic cells also increased in the samples irradiated with 0.5, 1, 2 and 5 Gy, in a radiation dose and time interval after irradiation manner, with the apoptosis being too great at 72 hours after irradiation. The dose-response curves were characterized by an initial steep increase in the number of apoptotic cells for irradiation doses below 2 Gy, with a flattening of the curves as the dose approached towards 5 Gy. The flow cytometric assay technique yielded adequate data, and required less than 1 mL of blood. The time and dose dependence of the radiation-induced apoptosis, was also shown. It is suggested that the adequate time interval required for the evaluation of apoptosis would be 24 to 48 hours after blood sampling

  20. High glucose induces apoptosis via upregulation of Bim expression in proximal tubule epithelial cells.

    Science.gov (United States)

    Zhang, Xiao-Qian; Dong, Jian-Jun; Cai, Tian; Shen, Xue; Zhou, Xiao-Jun; Liao, Lin

    2017-04-11

    Diabetic nephropathy is the primary cause of end-stage renal disease. Apoptosis of tubule epithelial cells is a major feature of diabetic nephropathy. The mechanisms of high glucose (HG) induced apoptosis are not fully understood. Here we demonstrated that, HG induced apoptosis via upregulating the expression of proapoptotic Bcl-2 homology domain 3 (BH3)-only protein Bim protein, but not bring a significant change in the baseline level of autophagy in HK2 cells. The increase of Bim expression was caused by the ugregulation of transcription factors, FOXO1 and FOXO3a. Bim expression initiates BAX/BAK-mediated mitochondria-dependent apoptosis. Silence of Bim by siRNA in HK2 cells prevented HG-induced apoptosis and also sensitized HK2 cells to autophagy during HG treatment. The autophagy inhibitor 3-MA increased the injury in Bim knockdown HK2 cells by retriggering apoptosis. The above results suggest a Bim-independent apoptosis pathway in HK2 cells, which normally could be inhibited by autophagy. Overall, our results indicate that HG induces apoptosis via up-regulation of Bim expression in proximal tubule epithelial cells.

  1. Surfactant protein D delays Fas- and TRAIL-mediated extrinsic pathway of apoptosis in T cells.

    Science.gov (United States)

    Djiadeu, Pascal; Kotra, Lakshmi P; Sweezey, Neil; Palaniyar, Nades

    2017-05-01

    Only a few extracellular soluble proteins are known to modulate apoptosis. We considered that surfactant-associated protein D (SP-D), an innate immune collectin present on many mucosal surfaces, could regulate apoptosis. Although SP-D is known to be important for immune cell homeostasis, whether SP-D affects apoptosis is unknown. In this study we aimed to determine the effects of SP-D on Jurkat T cells and human T cells dying by apoptosis. Here we show that SP-D binds to Jurkat T cells and delays the progression of Fas (CD95)-Fas ligand and TRAIL-TRAIL receptor induced, but not TNF-TNF receptor-mediated apoptosis. SP-D exerts its effects by reducing the activation of initiator caspase-8 and executioner caspase-3. SP-D also delays the surface exposure of phosphatidylserine. The effect of SP-D was ablated by the presence of caspase-8 inhibitor, but not by intrinsic pathway inhibitors. The binding ability of SP-D to dying cells decreases during the early stages of apoptosis, suggesting the release of apoptotic cell surface targets during apoptosis. SP-D also delays FasL-induced death of primary human T cells. SP-D delaying the progression of the extrinsic pathway of apoptosis could have important implications in regulating immune cell homeostasis at mucosal surfaces.

  2. Apoptosis in oral erythema multiforme.

    Science.gov (United States)

    Chrysomali, E; Lozada-Nur, F; Dekker, N P; Papanicolaou, S I; Regezi, J A

    1997-02-01

    Cell death was evaluated in oral erythema multiforme to test the hypothesis that apoptosis may be a mechanism by which keratinocytes die in this condition. Ten erythema multiforme and five control oral mucosa biopsy specimens were evaluated in immunohistochemically stained sections for apoptosis-regulating proteins Bcl-2, Bcl-x, Bax, p53, Fas, and Fas-ligand. Apoptotic keratinocytes, determined by a detection method for DNA fragmentation (TUNEL) and by conventional morphologic criteria were counted per high power field. Keratinocyte staining for Bcl-2 protein was comparable in erythema multiforme and controls. Bcl-x expression was reduced in five erythema multiforme cases. Staining for Bax protein differed in six erythema multiforme cases and showed variable intensity in layers under the parakeratin. Only slight differences in staining patterns of Fas and Fas-ligand proteins were noted between erythema multiforme and controls. The number of apoptotic keratinocytes evaluated by morphologic examination was significantly higher in erythema multiforme (mean per high power field, 0.90 +/- 0.2; controls, 0.06 +/- 0.04; p < 0.05, Mann-Whitney test) and was limited in significance by the TUNEL method (erythema multiforme, 0.43 +/- 0.1; controls, 0.02 +/- 0.02). Overexpression of p53 protein was seen in basal keratinocytes in five erythema multiforme specimens (mean, 17.5 +/- 4.03 per high power field; controls 1.2 +/- 0.3). There is evidence that cell death in erythema multiforme is at least in part due to apoptosis. The apoptotic mechanism may be related to an altered expression of apoptosis-regulating proteins. Although measurable alterations in the phenotypic expression of Fas and Fas-ligand proteins were not apparent, activation of Fas/Fas-ligand system could still be involved in the induction of apoptosis in erythema multiforme.

  3. Ray-optics analysis of inhomogeneous optically anisotropic media

    NARCIS (Netherlands)

    Sluijter, M.

    2010-01-01

    When the optical behavior of light in a medium depends on the direction in which light is traveling, the medium is called optically anisotropic. Light is an electromagnetic wave and in this thesis, we discuss the electromagnetic theory on optical anisotropy. We do this with the assumption that the

  4. On the origins of the anisotropic mechanical behaviour of extruded ...

    Indian Academy of Sciences (India)

    Mater. Sci., Vol. 40, No. 2, April 2017, pp. 395–406. c Indian Academy of Sciences. DOI 10.1007/s12034-017-1383-3. On the origins of the anisotropic mechanical behaviour of extruded. AA2017 aluminium alloy. A MAY. Laboratoire Génie des Matériaux, Ecole Militaire Polytechnique, BP 17, Bordj El Bahri 16046, Algeria.

  5. Negative index of refraction in anisotropic nonmagnetic materials

    Czech Academy of Sciences Publication Activity Database

    Dvořák, Vladimír; Kužel, Petr

    2006-01-01

    Roč. 338, - (2006), s. 195-203 ISSN 0015-0193 R&D Projects: GA AV ČR 1ET300100401 Institutional research plan: CEZ:AV0Z10100520 Keywords : anisotropic dielectric * negative refractive index * surface modes * guided modes Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 0.389, year: 2006

  6. Finite-difference modelling of anisotropic wave scattering in discrete ...

    Indian Academy of Sciences (India)

    A M Ekanem

    2018-04-05

    Apr 5, 2018 ... fractured hydrocarbon reservoirs to complement the use of other seismic attributes. Despite the con- certed effort in research and development related to seismic characterization of fractured reservoirs using anisotropic wave scattering, pragmatic uti- lization of this attribute in geophysical exploration.

  7. Autofocus imaging : Experimental results in an anisotropic austenitic weld

    NARCIS (Netherlands)

    Zhang, J.; Drinkwater, B.W.; Wilcox, P.D.; Hunter, A.J.

    2012-01-01

    The quality of an ultrasonic array image, especially for anisotropic material, depends on accurate information about acoustic properties. Inaccuracy of acoustic properties causes image degradation, e.g., blurring, errors in locating of reflectors and introduction of artifacts. In this paper, for an

  8. On the interpretation of time-resolved anisotropic diffraction patterns

    DEFF Research Database (Denmark)

    Lorenz, Ulf; Møller, Klaus Braagaard; Henriksen, Niels Engholm

    2010-01-01

    In this paper, we review existing systematic treatments for the interpretation of anisotropic diffraction patterns from partially aligned symmetric top molecules. Such patterns arise in the context of time-resolved diffraction experiments. We calculate diffraction patterns for ground-state Na...

  9. On the origins of the anisotropic mechanical behaviour of extruded ...

    Indian Academy of Sciences (India)

    This paper presents some experimental investigations about the origins of the anisotropic behaviour in cyclic loadings of AA2017 aluminium alloy. In the first step, fatigue damage evolutions were quantified for controlled proportional cyclic loadings in axial and shear directions. In this stage, the aim was to confirm the ...

  10. Anisotropic cosmological models and generalized scalar tensor theory

    Indian Academy of Sciences (India)

    Abstract. In this paper generalized scalar tensor theory has been considered in the background of anisotropic cosmological models, namely, axially symmetric Bianchi-I, Bianchi-III and Kortowski–. Sachs space-time. For bulk viscous fluid, both exponential and power-law solutions have been stud- ied and some assumptions ...

  11. Anisotropic cosmological models and generalized scalar tensor theory

    Indian Academy of Sciences (India)

    In this paper generalized scalar tensor theory has been considered in the background of anisotropic cosmological models, namely, axially symmetric Bianchi-I, Bianchi-III and Kortowski–Sachs space-time. For bulk viscous fluid, both exponential and power-law solutions have been studied and some assumptions among the ...

  12. Propagation of waves in a gravitating and rotating anisotropic heat ...

    African Journals Online (AJOL)

    Bheema

    (1956) equations neglecting the heat flux vector. Gravitational instability on propagation of magnetohydrodynamic (MHD) waves in astrophysical plasma is investigated by Alemayehu and Tessema (2013a) by considering the effect of gravitational instability and viscosity with anisotropic pressure tensor and heat conducting.

  13. Three anisotropic benchmark problems for adaptive finite element methods

    Czech Academy of Sciences Publication Activity Database

    Šolín, Pavel; Čertík, O.; Korous, L.

    2013-01-01

    Roč. 219, č. 13 (2013), s. 7286-7295 ISSN 0096-3003 R&D Projects: GA AV ČR IAA100760702 Institutional support: RVO:61388998 Keywords : benchmark problem * anisotropic solution * boundary layer Subject RIV: BA - General Mathematics Impact factor: 1.600, year: 2013

  14. Metastability thresholds for anisotropic bootstrap percolation in three dimensions

    NARCIS (Netherlands)

    Van Enter, A.C.D.; Fey, A.

    2012-01-01

    In this paper we analyze several anisotropic bootstrap percolation models in three dimensions. We present the order of magnitude for the metastability thresholds for a fairly general class of models. In our proofs, we use an adaptation of the technique of dimensional reduction. We find that the

  15. Metastability Thresholds for Anisotropic Bootstrap Percolation in Three Dimensions

    NARCIS (Netherlands)

    Van Enter, A.C.D.; Fey, A.

    2012-01-01

    In this paper we analyze several anisotropic bootstrap percolation models in three dimensions. We present the order of magnitude for the metastability thresholds for a fairly general class of models. In our proofs, we use an adaptation of the technique of dimensional reduction. We find that the

  16. Finite-size effects for anisotropic bootstrap percolation : Logarithmic corrections

    NARCIS (Netherlands)

    van Enter, Aernout C. D.; Hulshof, Tim

    In this note we analyse an anisotropic, two-dimensional bootstrap percolation model introduced by Gravner and Griffeath. We present upper and lower bounds on the finite-size effects. We discuss the similarities with the semi-oriented model introduced by Duarte.

  17. Metastability Thresholds for Anisotropic Bootstrap Percolation in Three Dimensions

    NARCIS (Netherlands)

    Enter, Aernout C.D. van; Fey, Anne

    In this paper we analyze several anisotropic bootstrap percolation models in three dimensions. We present the order of magnitude for the metastability thresholds for a fairly general class of models. In our proofs, we use an adaptation of the technique of dimensional reduction. We find that the

  18. Some dynamical properties of anisotropic collisionless stellar systems

    International Nuclear Information System (INIS)

    Bertin, G.; Pegoraro, F.

    1989-01-01

    The linear stability analysis of collisionless anisotropic spherical stellar systems presents many unresolved issues. Planning to study the stability of a simple and astrophysically interesting equilibrium seuence ∞ for such stellar systems, we describe here some analytical characterizations of the ∞-distribution functions, formulate the linearized equations for stability, and discuss the relevant boundary conditions. (author). 19 refs.; 1 tab

  19. New exact models for anisotropic matter with electric field

    Indian Academy of Sciences (India)

    Jefta M Sunzu

    2017-09-05

    Sep 5, 2017 ... In our models, we consider the stellar object that is anisotropic and charged with linear equation of state consistent with quark stars. ... Einstein–Maxwell equations; anisotropy; charged matter; equation of state. PACS Nos 04.20. .... Sunzu et al [3] which was a general cubic polynomial. However, our choice ...

  20. Wave propagation in a general anisotropic poroelastic medium ...

    Indian Academy of Sciences (India)

    equations (Auriault et al 1985) in terms of solid displacement and fluid pressure, whereas Biot's equations were in terms of displacements of both the solid and fluid phases. Homogenisation has proven that .... (8) to (10) imply that, in homogenisation approach, the anisotropic inertial coupling is hiding in the tensor {ˆρij}.

  1. Exact anisotropic sphere with polytropic equation of state

    Indian Academy of Sciences (India)

    Abstract. We study static spherically symmetric spacetime to describe compact objects with anisotropic matter distribution. We express the system of Einstein field equations as a new system of differential equations using a coordinate transformation, and then write the system in another form with polytropic equation of state ...

  2. Anisotropic Born-Mayer potential in lattice dynamics of Vanadium

    International Nuclear Information System (INIS)

    Onwuagba, B.N.

    1988-01-01

    A microscopic theory of the lattice dynamics of the transition metal vanadium is developed based on the Animalu's transition metal model potential (TMMP). The Born-Mayer potential associated with the distribution of the transition metal d-electrons is treated as anisotropic. Good agreement with experimental phonon dispersion curves longitudinal branches in the [111] direction

  3. Anisotropic strain and phonon deformation potentials in GaN

    International Nuclear Information System (INIS)

    Darakchieva, V.; Arwin, H.; Paskov, P. P.; Monemar, B.; Paskova, T.; Hommel, D.; Schubert, M.; Heuken, M.; Off, J.; Scholz, F.; Haskell, B. A.; Fini, P. T.; Speck, J. S.; Nakamura, S.

    2007-01-01

    We report optical phonon frequency studies in anisotropically strained c-plane- and a-plane-oriented GaN films by generalized infrared spectroscopic ellipsometry and Raman scattering spectroscopy. The anisotropic strain in the films is obtained from high-resolution x-ray diffraction measurements. Experimental evidence for splitting of the GaN E 1 (TO), E 1 (LO), and E 2 phonons under anisotropic strain in the basal plane is presented, and their phonon deformation potentials c E 1 (TO) , c E 1 (LO) , and c E 2 are determined. A distinct correlation between anisotropic strain and the A 1 (TO) and E 1 (LO) frequencies of a-plane GaN films reveals the a A 1 (TO) , b A 1 (TO) , a E 1 (LO) , and b E 1 (LO) phonon deformation potentials. The a A 1 (TO) and b A 1 (TO) are found to be in very good agreement with previous results from Raman experiments [V. Yu. Davydov et al., J. Appl. Phys. 82, 5097 (1997)]. Our a A 1 (TO) and a E 1 (LO) phonon deformation potentials agree well with recently reported theoretical estimations [J.-M. Wagner and F. Bechstedt, Phys. Rev. B 66, 115202 (2002)], while b A 1 (TO) and b E 1 (LO) are found to be significantly larger than the theoretical values. A discussion of the observed differences is presented

  4. Double anisotropic electrically conductive flexible Janus-typed membranes.

    Science.gov (United States)

    Li, Xiaobing; Ma, Qianli; Tian, Jiao; Xi, Xue; Li, Dan; Dong, Xiangting; Yu, Wensheng; Wang, Xinlu; Wang, Jinxian; Liu, Guixia

    2017-12-07

    Novel type III anisotropic conductive films (ACFs), namely flexible Janus-typed membranes, were proposed, designed and fabricated for the first time. Flexible Janus-typed membranes composed of ordered Janus nanobelts were constructed by electrospinning, which simultaneously possess fluorescence and double electrically conductive anisotropy. For the fabrication of the Janus-typed membrane, Janus nanobelts comprising a conductive side and an insulative-fluorescent side were primarily fabricated, and then the Janus nanobelts are arranged into parallel arrays using an aluminum rotary drum as the collector to obtain a single anisotropically conductive film. Subsequently, a secondary electrospinning process was applied to the as-prepared single anisotropically conductive films to acquire the final Janus-typed membrane. For this Janus-typed membrane, namely its left-to-right structure, anisotropic electrical conduction synchronously exists on both sides, and furthermore, the two electrically conductive directions are perpendicular. By modulating the amount of Eu(BA) 3 phen complex and conducting polyaniline (PANI), the characteristics and intensity of the fluorescence-electricity dual-function in the membrane can be tuned. The high integration of this peculiar Janus-typed membrane with simultaneous double electrically conductive anisotropy-fluorescent dual-functionality is successfully realized in this study. This design philosophy and preparative technique will provide support for the design and construction of new types of special nanostructures with multi-functionality.

  5. Anisotropic cosmological models in f (R, T) theory of gravitation

    Indian Academy of Sciences (India)

    Bianchi spaces are useful tools for constructing spatially homogeneous and anisotropic cosmological models in general relativity and scalar–tensor theories of gravitation. Adhav [14] obtained exact solutions of the field equations for LRS. Bianchi type-I space-time with perfect fluid in the framework of f (R, T) theory of grav-.

  6. Anisotropic Bianchi-I universe with phantom field and cosmological ...

    Indian Academy of Sciences (India)

    We study an anisotropic Bianchi-I universe in the presence of a phantom field and a cosmological constant. Cosmological solutions are obtained when the kinetic energy of the phantom field is of the order of anisotropy and dominates over the potential energy of the field. The anisotropy of the universe decreases and the ...

  7. Gmax for Sand by Bender Elements at Anisotropic Stress States

    DEFF Research Database (Denmark)

    Bødker, L.

    1996-01-01

    elements for two types of sand and with void ratios varying from minimum to maximum. The tests performed are carried out in the Danish Triaxial Cell, and Gmax are determined at different isotropic and anisotropic stress states. The main result of the test program is that Gmax is primarily influenced...

  8. Charged anisotropic star on paraboloidal space-time

    Indian Academy of Sciences (India)

    ... is the central pressure. At the boundary of the star r = R, pr must vanish, which gives r = R as the radius of the star. This form of radial pressure is prescribed by Sharma and Ratanpal [18] to describe anisotropic stellar model admitting a quadratic equation of state on paraboloidal space-time. Equations (8) and (4) give ν =.

  9. New exact models for anisotropic matter with electric field

    Indian Academy of Sciences (India)

    2017-09-05

    Sep 5, 2017 ... We can also obtain particular anisotropic models obtained by Maharaj, Sunzu, and Ray. The exact solutions corresponding to our models are found explicitly in terms of elementary functions. The graphical plots generated for the matter variables and the electric field are well behaved. We also generate ...

  10. Anisotropic colloids: bulk phase behavior and equilibrium sedimentation

    NARCIS (Netherlands)

    Marechal, M.A.T.

    2009-01-01

    This thesis focuses on the phase behavior of anisotropically shaped (i.e. non-spherical) colloids using computer simulations. Only hard-core interactions between the colloids are taken into account to investigate the effects of shape alone. The bulk phase behavior of three different shapes of

  11. Surface waves in fibre-reinforced anisotropic elastic media

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    Abstract. Though the decoupling of displacement potentials in case of fibre- reinfoced anisotropic elastic media is not possible in the general case, an attempt has been made to decouple the equation as a particular case. The assumptions made in this paper satisfy both set of equations formed by the displacement ...

  12. Fracture of anisotropic materials with plastic strain-gradient effects

    DEFF Research Database (Denmark)

    Legarth, Brian Nyvang

    2013-01-01

    A unit cell is adopted to numerically analyze the effect of plastic anisotropy on frac-ture evolution in a micro-reinforced fiber-composite. The matrix material exhibit size-effects and an anisotropic strain-gradient plasticity model accounting for such size-effects through a mate-rial length scale...

  13. Angle-domain common-image gathers from anisotropic Gaussian ...

    Indian Academy of Sciences (India)

    s12040-016-0783-x. Angle-domain common-image gathers from anisotropic ..... are not flat. The test results demonstrate that anisotropy has a great influence on GB-PSDM in. VTI media, and ignoring anisotropy in migration may lead to obvious ...

  14. Exact anisotropic sphere with polytropic equation of state

    Indian Academy of Sciences (India)

    self-gravitating, static, isotropic fluid spheres when pressure explicitly depends on matter density, which invariably leads to non-integrable equations [32]. However, our treatment of anisotropic fluids with polytropic equation of state gets some flexibility in solving the. Einstein field equations with uncharged matter in static ...

  15. Dynamical anisotropic response of black phosphorus under magnetic field

    Science.gov (United States)

    Liu, Xuefeng; Lu, Wei; Zhou, Xiaoying; Zhou, Yang; Zhang, Chenglong; Lai, Jiawei; Ge, Shaofeng; Sekhar, M. Chandra; Jia, Shuang; Chang, Kai; Sun, Dong

    2018-04-01

    Black phosphorus (BP) has emerged as a promising material candidate for next generation electronic and optoelectronic devices due to its high mobility, tunable band gap and highly anisotropic properties. In this work, polarization resolved ultrafast mid-infrared transient reflection spectroscopy measurements are performed to study the dynamical anisotropic optical properties of BP under magnetic fields up to 9 T. The relaxation dynamics of photoexcited carrier is found to be insensitive to the applied magnetic field due to the broadening of the Landau levels and large effective mass of carriers. While the anisotropic optical response of BP decreases with increasing magnetic field, its enhancement due to the excitation of hot carriers is similar to that without magnetic field. These experimental results can be well interpreted by the magneto-optical conductivity of the Landau levels of BP thin film, based on an effective k · p Hamiltonian and linear response theory. These findings suggest attractive possibilities of multi-dimensional control of anisotropic response (AR) of BP with light, electric and magnetic field, which further introduces BP to the fantastic magnetic field sensitive applications.

  16. Theory of Spin Waves in Strongly Anisotropic Magnets

    DEFF Research Database (Denmark)

    Lindgård, Per-Anker; Cooke, J. F.

    1976-01-01

    A new infinite-order perturbation approach to the theory of spin waves in strongly anisotropic magnets is introduced. The system is transformed into one with effective two-ion anisotropy and considerably reduced ground-state corrections. A general expression for the spin-wave energy, valid to any...

  17. Minimal Sampling for Effective Acquisition of Anisotropic BRDFs

    Czech Academy of Sciences Publication Activity Database

    Vávra, Radomír; Filip, Jiří

    2016-01-01

    Roč. 35, č. 7 (2016), s. 299-309 ISSN 0167-7055 R&D Projects: GA ČR(CZ) GA14-02652S Institutional support: RVO:67985556 Keywords : BRDF * anisotropic * measurement Subject RIV: BD - Theory of Information Impact factor: 1.611, year: 2016 http://library.utia.cas.cz/separaty/2016/RO/vavra-0463872.pdf

  18. Viscoelastic materials with anisotropic rigid particles: stress-deformation behavior

    NARCIS (Netherlands)

    Sagis, L.M.C.; Linden, van der E.

    2001-01-01

    In this paper we have derived constitutive equations for the stress tensor of a viscoelastic material with anisotropic rigid particles. We have assumed that the material has fading memory. The expressions are valid for slow and small deformations from equilibrium, and for systems that are nearly

  19. Propagation of waves in a gravitating and rotating anisotropic heat ...

    African Journals Online (AJOL)

    An inviscid, unbounded, collisionless, gravitating, rotating and heat conducting anisotropic plasma medium which is drifting is considered. The medium is assumed to be embedded in a strong magnetic field. A general dispersion relation is derived using normal mode analysis and its various limiting cases are discussed, ...

  20. Finite-difference modelling of anisotropic wave scattering in discrete ...

    Indian Academy of Sciences (India)

    2

    attribute in geophysical exploration is still restricted perhaps as a result of the ambiguity in its. 51 quantification and difficulty in its interpretation in terms of rock properties (Jeng et al., 1999,. 52. MacBeth, 1999; Rongrong et al., 2006). Thus, the task of using anisotropic wave scattering for fracture. 53 prediction in the Earth's ...

  1. Fourth-order discrete anisotropic boundary-value problems

    Directory of Open Access Journals (Sweden)

    Maciej Leszczynski

    2015-09-01

    Full Text Available In this article we consider the fourth-order discrete anisotropic boundary value problem with both advance and retardation. We apply the direct method of the calculus of variations and the mountain pass technique to prove the existence of at least one and at least two solutions. Non-existence of non-trivial solutions is also undertaken.

  2. Prestack exploding reflector modelling and migration for anisotropic media

    KAUST Repository

    Alkhalifah, Tariq Ali

    2014-10-09

    The double-square-root equation is commonly used to image data by downward continuation using one-way depth extrapolation methods. A two-way time extrapolation of the double-square-root-derived phase operator allows for up and downgoing wavefields but suffers from an essential singularity for horizontally travelling waves. This singularity is also associated with an anisotropic version of the double-square-root extrapolator. Perturbation theory allows us to separate the isotropic contribution, as well as the singularity, from the anisotropic contribution to the operator. As a result, the anisotropic residual operator is free from such singularities and can be applied as a stand alone operator to correct for anisotropy. We can apply the residual anisotropy operator even if the original prestack wavefield was obtained using, for example, reverse-time migration. The residual correction is also useful for anisotropic parameter estimation. Applications to synthetic data demonstrate the accuracy of the new prestack modelling and migration approach. It also proves useful in approximately imaging the Vertical Transverse Isotropic Marmousi model.

  3. Angle-domain common-image gathers from anisotropic Gaussian ...

    Indian Academy of Sciences (India)

    An approach for extracting angle-domain common-image gathers (ADCIGs) from anisotropic Gaussian beam prestack depth migration (GB-PSDM) is presented in this paper. The propagation angle is calcu- lated in the process of migration using the real-value traveltime information of Gaussian beam. Based on the above ...

  4. Anisotropic properties of aligned SWNT modified poly (methyl ...

    Indian Academy of Sciences (India)

    The electrical and mechanical properties of PMMA/SWNT composite were studied as a function of SWNT orientation and concentration. The aligned SWNT modified PMMA/SWNT composite presented highly anisotropic properties. The experimental results showed that the electrical conductivity and mechanical properties of ...

  5. Surface waves in fibre-reinforced anisotropic elastic media

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    MS received 1 March 2002. Abstract. In the paper under discussion, the problem of surface waves in fibre- reinforced anisotropic elastic media has been studied. The authors express the plane strain displacement components in terms of two scalar potentials to decouple the plane motion into P and SV waves. In the present ...

  6. Crystal structure of vanadite: Refinement of anisotropic displacement parameters

    Czech Academy of Sciences Publication Activity Database

    Laufek, F.; Skála, Roman; Haloda, J.; Císařová, I.

    2006-01-01

    Roč. 51, 3-4 (2006), s. 271-275 ISSN 1210-8197 Institutional research plan: CEZ:AV0Z30130516 Keywords : anisotropic displacement parameter * crystal structure * single-crystal X-ray refinement * vanadinite Subject RIV: DB - Geology ; Mineralogy

  7. Finite-difference modelling of anisotropic wave scattering in discrete ...

    Indian Academy of Sciences (India)

    2

    cells containing equivalent anisotropic medium by the use of the linear slip equivalent model. Our. 16 results show ...... frequency regression predicted by equation (21) can be distorted by the effects of multiple scattering. 337 ..... other seismic attributes, at least for the relatively simple geometries of subsurface structure. 449.

  8. Anisotropic hydrodynamic modeling of 2.76 TeV Pb-Pb collisions

    Science.gov (United States)

    Alqahtani, Mubarak; Nopoush, Mohammad; Ryblewski, Radoslaw; Strickland, Michael

    2017-10-01

    We compare phenomenological results from 3 +1 D quasiparticle anisotropic hydrodynamics (aHydroQP) with experimental data collected in the CERN Large Hadron Collider 2.76 TeV Pb-Pb collisions. In particular, we present comparisons of particle spectra, average transverse momentum, elliptic flow, and Hanbury Brown-Twiss radii. The aHydroQP model relies on the introduction of a single temperature-dependent quasiparticle mass which is fit to lattice QCD data. By taking moments of the resulting Boltzmann equation, we obtain the dynamical equations used in the hydrodynamic stage which include the effects of both shear and bulk viscosities. At freeze-out, we use anisotropic Cooper-Frye freeze-out performed on a fixed-energy-density hypersurface to convert to hadrons. To model the production and decays of the hadrons we use therminator2 which is customized to sample from ellipsoidal momentum-space distribution functions. Using smooth Glauber initial conditions, we find very good agreement with many heavy-ion collision observables.

  9. An efficient Matlab script to calculate heterogeneous anisotropically elastic wave propagation in three dimensions

    Science.gov (United States)

    Boyd, O.S.

    2006-01-01

    We have created a second-order finite-difference solution to the anisotropic elastic wave equation in three dimensions and implemented the solution as an efficient Matlab script. This program allows the user to generate synthetic seismograms for three-dimensional anisotropic earth structure. The code was written for teleseismic wave propagation in the 1-0.1 Hz frequency range but is of general utility and can be used at all scales of space and time. This program was created to help distinguish among various types of lithospheric structure given the uneven distribution of sources and receivers commonly utilized in passive source seismology. Several successful implementations have resulted in a better appreciation for subduction zone structure, the fate of a transform fault with depth, lithospheric delamination, and the effects of wavefield focusing and defocusing on attenuation. Companion scripts are provided which help the user prepare input to the finite-difference solution. Boundary conditions including specification of the initial wavefield, absorption and two types of reflection are available. ?? 2005 Elsevier Ltd. All rights reserved.

  10. Electrospun PCL nanofibers with anisotropic mechanical properties as a biomedical scaffold

    International Nuclear Information System (INIS)

    Kim, Geun Hyung

    2008-01-01

    To design an ideal scaffold, various factors should be considered, such as pore size and morphology, mechanical properties versus porosity, surface properties and appropriate biodegradability. Of these factors, the importance of mechanical properties on cell growth is particularly obvious in tissues such as bone, cartilage, blood vessels, tendons and muscles. Although electrospun nanofibers provide easily applicable nano-sized structures which could be used as biomedical scaffolds, the mechanical properties are poor since an increased pore size and porosity are generally accompanied by a decrease in mechanical properties. In addition, the general electrospinning has been limited to the fabrication of a variety of anisotropic mechanical properties, which are extremely important parameters for designing a musculoskeletal system. In this study, scaffolds consisting of variously oriented nanofibers were produced using an electrospinning process modified with an auxiliary electrode and a two-axis robot collecting system. Using an auxiliary electrode, a stable Taylor cone and initial spun jets were obtained. The influence of the electrode was evaluated with electric field simulation. Using the modified electrospinning process, various directions of orientation of electrospun fibers could be acquired and the fabricated oriented nanofiber webs showed a mechanically anisotropic behavior and a higher hydrophilic property compared to randomly distributed fibrous mats

  11. Two coffins and a funeral: early or late caspase activation determines two types of apoptosis induced by DNA damaging agents.

    Science.gov (United States)

    Oropesa-Ávila, Manuel; de la Cruz-Ojeda, Patricia; Porcuna, Jesús; Villanueva-Paz, Marina; Fernández-Vega, Alejandro; de la Mata, Mario; de Lavera, Isabel; Rivero, Juan Miguel Suarez; Luzón-Hidalgo, Raquel; Álvarez-Córdoba, Mónica; Cotán, David; Zaderenko, Ana Paula; Cordero, Mario D; Sánchez-Alcázar, José A

    2017-03-01

    Cell cytoskeleton makes profound changes during apoptosis including the organization of an Apoptotic Microtubule Network (AMN). AMN forms a cortical structure which plays an important role in preserving plasma membrane integrity during apoptosis. Here, we examined the cytoskeleton rearrangements during apoptosis induced by camptothecin (CPT), a topoisomerase I inhibitor, in human H460 and porcine LLCPK-1α cells. Using fixed and living cell imaging, we showed that CPT induced two dose- and cell cycle-dependent types of apoptosis characterized by different cytoskeleton reorganizations, time-dependent caspase activation and final apoptotic cell morphology. In the one referred as "slow" (~h) or round-shaped, apoptosis was characterized by a slow contraction of the actinomyosin ring and late caspase activation. In "slow" apoptosis the γ-tubulin complexes were not disorganized and microtubules were not depolymerized at early stages. In contrast, "fast" (~min) or irregular-shaped apoptosis was characterized by early caspase activation followed by full contraction of the actinomyosin ring. In fast apoptosis γ-tubulin complexes were disorganized and microtubules were initially depolymerized. However, after actinomyosin contraction, microtubules were reformed adopting a cortical but irregular disposition near plasma membrane. In addition to distinctive cytoskeleton reorganization kinetics, round and irregular-shaped apoptosis showed different biological properties with respect to AMN maintenance, plasma membrane integrity and phagocytes response. Our results suggest that the knowledge and modulation of the type of apoptosis promoted by genotoxic agents may be important for deciding a better therapeutic option and predicting the immune response in cancer treatment.

  12. Influence of copper foil polycrystalline structure on graphene anisotropic etching

    Energy Technology Data Exchange (ETDEWEB)

    Sharma, Kamal P. [Department of Frontier Materials, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555 (Japan); Mahyavanshi, Rakesh D. [Department of Physical Science and Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555 (Japan); Kalita, Golap, E-mail: kalita.golap@nitech.ac.jp [Department of Frontier Materials, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555 (Japan); Department of Physical Science and Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555 (Japan); Tanemura, Masaki [Department of Frontier Materials, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555 (Japan); Department of Physical Science and Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555 (Japan)

    2017-01-30

    Graphical abstract: Hexagonal hole formation with anisotropic etching independent of the stripes and wrinkles in the synthesized graphene. We also observed variation in etched pattern of the graphene depending on the base Cu grain orientations, attributing to difference in nucleation and growth process. - Highlights: • Reveal the influence of copper polycrystalline structure on anisotropic etching of graphene. • Hexagonal hole formation with etching is observed to be independent of stripes and wrinkles in graphene. • Variation in etched pattern of graphene depending on the base Cu grain is confirmed. • This finding will help to understand the nature of microscopic etched pattern in graphene. - Abstract: Anisotropic etching of graphene and other two dimensional materials is an important tool to understand the growth process as well as enabling fabrication of various well-defined structures. Here, we reveal the influence of copper foil polycrystalline structure on anisotropic etching process of as-synthesized graphene. Graphene crystals were synthesized on the polycrystalline Cu foil by a low-pressure chemical vapor deposition (LPCVD) system. Microscopic analysis shows difference in shape, size and stripes alignment of graphene crystals with dissimilar nucleation within closure vicinity of neighboring Cu grains. Post-growth etching of such graphene crystals also significantly affected by the crystallographic nature of Cu grains as observed by the field emission scanning electron microscope (FE-SEM) and electron back scattered diffraction (EBSD) analysis. Hexagonal hole formation with anisotropic etching is observed to be independent of the stripes and wrinkles in the synthesized graphene. We also observed variation in etched pattern of the graphene depending on the base Cu grain orientations, attributing to difference in nucleation and growth process. The findings can facilitate to understand the nature of microscopic etched pattern depending on metal

  13. Effective wavefield extrapolation in anisotropic media: Accounting for resolvable anisotropy

    KAUST Repository

    Alkhalifah, Tariq Ali

    2014-04-30

    Spectral methods provide artefact-free and generally dispersion-free wavefield extrapolation in anisotropic media. Their apparent weakness is in accessing the medium-inhomogeneity information in an efficient manner. This is usually handled through a velocity-weighted summation (interpolation) of representative constant-velocity extrapolated wavefields, with the number of these extrapolations controlled by the effective rank of the original mixed-domain operator or, more specifically, by the complexity of the velocity model. Conversely, with pseudo-spectral methods, because only the space derivatives are handled in the wavenumber domain, we obtain relatively efficient access to the inhomogeneity in isotropic media, but we often resort to weak approximations to handle the anisotropy efficiently. Utilizing perturbation theory, I isolate the contribution of anisotropy to the wavefield extrapolation process. This allows us to factorize as much of the inhomogeneity in the anisotropic parameters as possible out of the spectral implementation, yielding effectively a pseudo-spectral formulation. This is particularly true if the inhomogeneity of the dimensionless anisotropic parameters are mild compared with the velocity (i.e., factorized anisotropic media). I improve on the accuracy by using the Shanks transformation to incorporate a denominator in the expansion that predicts the higher-order omitted terms; thus, we deal with fewer terms for a high level of accuracy. In fact, when we use this new separation-based implementation, the anisotropy correction to the extrapolation can be applied separately as a residual operation, which provides a tool for anisotropic parameter sensitivity analysis. The accuracy of the approximation is high, as demonstrated in a complex tilted transversely isotropic model. © 2014 European Association of Geoscientists & Engineers.

  14. R2 inflation in anisotropic universes

    International Nuclear Information System (INIS)

    Berkin, A.L.

    1990-01-01

    The evolution of Bianchi type-I and type-IX universes for a theory of gravity with an εR 2 term added to the usual Lagrangian is considered. As in the spatially flat Robertson-Walker case considered previously by others, inflation is found to occur. For any amount of initial anisotropy, the anisotropy decays quickly relative to the length of the inflationary epoch, and the amount of expansion is enhanced by the anisotropy. The exceptions are Bianchi type-IX universes near or at isotropy. In these cases a wide range of initial parameters causes the universe to recollapse, thus reducing the phase space in which inflation can occur. The diagonal metric is shown to be the most general form in the R 2 theory for both Bianchi type-I universes with a perfect fluid and vacuum Bianchi type-IX models

  15. Debonding of perticles in anisotropic materials

    DEFF Research Database (Denmark)

    Legarth, Brian Nyvang

    2003-01-01

    Effects of geometrical anisotropy as well as plastic anisotropy are studied in relation to debonding of rigid inclusions embedded in a metal. Full finite strain analyses are carried out for a cell model under plane strain conditions, and the average overall stress-strain response of the cell...... is calculated. For increased triaxiality the onset of matrix-particle debonding occurs at a significantly reduced overall strain of the cell. The point of initial debonding is nearly unaffected by variations of the shape of the inclusions, but complete debonding occurs earlier if the inclusions are elongated...... perpendicular to the main tensile direction. The same effect is observed, if the spacing of the inclusions is larger in the main tensile direction than in the transverse direction. For the orientations of plastic anisotropy considered, the debonding initiates and grows at a much lower overall strain than...

  16. Interference of Apoptosis by Hepatitis B Virus.

    Science.gov (United States)

    Lin, Shaoli; Zhang, Yan-Jin

    2017-08-18

    Hepatitis B virus (HBV) causes liver diseases that have been a consistent problem for human health, leading to more than one million deaths every year worldwide. A large proportion of hepatocellular carcinoma (HCC) cases across the world are closely associated with chronic HBV infection. Apoptosis is a programmed cell death and is frequently altered in cancer development. HBV infection interferes with the apoptosis signaling to promote HCC progression and viral proliferation. The HBV-mediated alteration of apoptosis is achieved via interference with cellular signaling pathways and regulation of epigenetics. HBV X protein (HBX) plays a major role in the interference of apoptosis. There are conflicting reports on the HBV interference of apoptosis with the majority showing inhibition of and the rest reporting induction of apoptosis. In this review, we described recent studies on the mechanisms of the HBV interference with the apoptosis signaling during the virus infection and provided perspective.

  17. Interference of Apoptosis by Hepatitis B Virus

    Science.gov (United States)

    2017-01-01

    Hepatitis B virus (HBV) causes liver diseases that have been a consistent problem for human health, leading to more than one million deaths every year worldwide. A large proportion of hepatocellular carcinoma (HCC) cases across the world are closely associated with chronic HBV infection. Apoptosis is a programmed cell death and is frequently altered in cancer development. HBV infection interferes with the apoptosis signaling to promote HCC progression and viral proliferation. The HBV-mediated alteration of apoptosis is achieved via interference with cellular signaling pathways and regulation of epigenetics. HBV X protein (HBX) plays a major role in the interference of apoptosis. There are conflicting reports on the HBV interference of apoptosis with the majority showing inhibition of and the rest reporting induction of apoptosis. In this review, we described recent studies on the mechanisms of the HBV interference with the apoptosis signaling during the virus infection and provided perspective. PMID:28820498

  18. The cephalostatin way of apoptosis.

    Science.gov (United States)

    Rudy, Anita; López-Antón, Nancy; Dirsch, Verena M; Vollmar, Angelika M

    2008-03-01

    The cephalostatins, bis-steroidal natural products from the marine tube worm Cephalodiscus gilchristi, were isolated by Dr. G. R. Pettit and his group. These compounds show a unique cytotoxicity profile in the in vitro screen of the National Cancer Institute, suggesting a novel mechanism of action. Indeed, cephalostatin 1 ( 1) is an extremely powerful agent that acts via an unusual apoptosis pathway. It induces selective Smac/DIABLO, but no cytochrome c release from mitochondria. Nevertheless, caspase-9 is required for apoptosis induction. Interestingly, caspase-9 is activated without the participation of the apoptosome, leading to the question of its mechanism of activation. We found that endoplasmic reticulum stress-associated caspase-4 contributes to nonclassical cephalostatin-mediated caspase-9 activation, additionally pointing out the unusual pathway used by this substance. Cephalostatin 1 ( 1), therefore, provides a very good tool to discover novel apoptotic pathways, which might be important in the understanding and treatment of chemo-resistant cancer.

  19. Methylselenium and Prostate Cancer Apoptosis

    Science.gov (United States)

    2003-02-01

    miethylselenol generated in cell-culture medium by described previously [12,15]. All cell-culture workwas performed without antibiotics . L-methionine-cL-deamino...Thompson HJ. Effect of 16. Datta SR, Brunet A, Greenberg ME. Cellular survival: A play an aqueous extract of selenium enriched garlic on in vitro in three... garlic on in vitro markers and relationship to caspase-mediated apoptosis execution. The in vivo efficacy in cancer prevention. Carcinogenesis (Lond.), 17

  20. Apoptosis and Self-Destruct: A Contribution to Autonomic Agents?

    Science.gov (United States)

    Sterritt, Roy; Hinchey, Mike

    2004-01-01

    Autonomic Computing (AC), a self-managing systems initiative based on the biological metaphor of the autonomic nervous system, is increasingly gaining momentum as the way forward in designing reliable systems. Agent technologies have been identified as a key enabler for engineering autonomicity in systems, both in terms of retrofitting autonomicity into legacy systems and designing new systems. The AC initiative provides an opportunity to consider other biological systems and principles in seeking new design strategies. This paper reports on one such investigation; utilizing the apoptosis metaphor of biological systems to provide a dynamic health indicator signal between autonomic agents.

  1. Quantitative multi-waves migration in elastic anisotropic media; Migration quantitative multi-ondes en milieu elastique anisotrope

    Energy Technology Data Exchange (ETDEWEB)

    Borgne, H.

    2004-12-01

    Seismic imaging is an important tool for ail exploration. From the filtered seismic traces and a subsurface velocity model, migration allows to localize the reflectors and to estimate physical properties of these interfaces. The subsurface is split up into a reference medium, corresponding to the low spatial frequencies (a smooth medium), and a perturbation medium, corresponding to the high spatial frequencies. The propagation of elastic waves in the medium of reference is modelled by the ray theory. The association of this theory with a principle of diffraction or reflection allows to take into account the high spatial frequencies: the Kirchhoff approach represents so the medium of perturbations with continuous surfaces, characterized by reflection coefficients. The target of the quantitative migration is to reconstruct this reflection coefficient, notably its behaviour according to the incidence angle. These information will open the way to seismic characterization of the reservoir domain, with. a stratigraphic inversion for instance. In order to improve the qualitative and quantitative migration results, one of the current challenges is to take into account the anisotropy of the subsurface. Taking into account rocks anisotropy in the imaging process of seismic data requires two improvements from the isotropic case. The first one roughly concerns the modelling aspect: an anisotropic propagator should be used to avoid a mis-positioning or bad focusing of the imaged reflectors. The second correction concerns the migration aspect: as anisotropy affects the reflectivity of subsurface, a specific anisotropic imaging formula should be applied in the migration kernel, in order to recover the correct A V A behavior of the subsurface reflectors, If the first correction is DOW made in most so-called anisotropic imaging algorithms, the second one is currently ignored. The first part of my work concerns theoretical aspects. 1 study first the preservation of amplitudes in the

  2. An ultrasonic methodology to non-destructively estimate the grain orientation in an anisotropic weld

    Directory of Open Access Journals (Sweden)

    Wirdelius Håkan

    2014-06-01

    Full Text Available The initial step towards a non-destructive technique that estimates grain orientation in an anisotropic weld is presented in this paper. The purpose is to aid future forward simulations of ultrasonic NDT of this kind of weld to achieve a better result. A forward model that consists of a weld model, a transmitter model, a receiver model and a 2D ray tracing algorithm is introduced. An inversion based on a multi-objective genetic algorithm is also presented. Experiments are conducted for both P and SV waves in order to collect enough data used in the inversion. Calculation is conducted to fulfil the estimation with both the synthetic data and the experimental data. Concluding remarks are presented at the end of the paper.

  3. Nanoscale Rheology and Anisotropic Diffusion Using Single Gold Nanorod Probes

    Science.gov (United States)

    Molaei, Mehdi; Atefi, Ehsan; Crocker, John C.

    2018-03-01

    The complex rotational and translational Brownian motion of anisotropic particles depends on their shape and the viscoelasticity of their surroundings. Because of their strong optical scattering and chemical versatility, gold nanorods would seem to provide the ultimate probes of rheology at the nanoscale, but the suitably accurate orientational tracking required to compute rheology has not been demonstrated. Here we image single gold nanorods with a laser-illuminated dark-field microscope and use optical polarization to determine their three-dimensional orientation to better than one degree. We convert the rotational diffusion of single nanorods in viscoelastic polyethylene glycol solutions to rheology and obtain excellent agreement with bulk measurements. Extensions of earlier models of anisotropic translational diffusion to three dimensions and viscoelastic fluids give excellent agreement with the observed motion of single nanorods. We find that nanorod tracking provides a uniquely capable approach to microrheology and provides a powerful tool for probing nanoscale dynamics and structure in a range of soft materials.

  4. Optical characterization of isotropic and anisotropic layered media

    CERN Document Server

    Jakopic, G

    2000-01-01

    This work deals with the interaction of electromagnetic radiation in the UV/IR region with layered media and the inversion of photometric and ellipsometric spectra. A method is presented how to calculate the dielectric function of an ensemble of different anisotropic oscillators. A way is proposed how to extract both components of the dielectric tensor of uniaxial oligomers out of spectroscopic measurements at normal incidence, if it is possible to make two different structural modifications of the oligomer. Then, effective medium theories with an expansion on anisotropic media are treated and the result is used to model the optical properties of the rough surface of an organic thin film. Further, a new unified analytical inversion of reflectometric and ellipsometric data of strongly absorbing media is presented. A method is shown how to calculate simultaneously the thickness and the optical constants of weakly absorbing films out of one spectroscopic reflection or transmission measurement. The last topic are...

  5. A resistor interpretation of general anisotropic cardiac tissue.

    Science.gov (United States)

    Shao, Hai; Sampson, Kevin J; Pormann, John B; Rose, Donald J; Henriquez, Craig S

    2004-02-01

    This paper describes a spatial discretization scheme for partial differential equation systems that contain anisotropic diffusion. The discretization method uses unstructured finite volumes, or the boxes, that are formed as a secondary geometric structure from an underlying triangular mesh. We show how the discretization can be interpreted as a resistive circuit network, where each resistor is assigned at each edge of the triangular element. The resistor is computed as an anisotropy dependent geometric quantity of the local mesh structure. Finally, we show that under certain conditions, the discretization gives rise to negative resistors that can produce non-physical hyperpolarizations near depolarizing stimuli. We discuss how the proper choice of triangulation (anisotropic Delaunay triangulation) can ensure monotonicity (i.e. all resistors are positive).

  6. Anisotropic hypersonic phonon propagation in films of aligned ellipsoids.

    Science.gov (United States)

    Beltramo, Peter J; Schneider, Dirk; Fytas, George; Furst, Eric M

    2014-11-14

    A material with anisotropic elastic mechanical properties and a direction-dependent hypersonic band gap is fabricated using ac electric field-directed convective self-assembly of colloidal ellipsoids. The frequency of the gap, which is detected in the direction perpendicular to particle alignment and entirely absent parallel to alignment, and the effective sound velocities can be tuned by the particle aspect ratio. We hypothesize that the band gap originates from the primary eigenmode peak, the m-splitted (s,1,2) mode, of the particle resonating with the effective medium. These results reveal the potential for powerful control of the hypersonic phononic band diagram by combining anisotropic particles and self-assembly.

  7. Coupled polaritonic band gaps in the anisotropic piezoelectric superlattices

    Science.gov (United States)

    Tang, Zheng-Hua; Jiang, Zheng-Sheng; Chen, Tao; Jiang, Chun-Zhi; Lei, Da-Jun; Huang, Jian-Quan; Qiu, Feng; Yao, Min; Huang, Xiao-Yi

    2018-01-01

    Anisotropic piezoelectric superlattices (APSs) with the periodic arrangement of polarized anisotropic piezoelectric domains in a certain direction are presented, in which the coupled polaritonic band gaps (CPBGs) can be obtained in the whole Brillouin Zone and the maximum relative bandwidth (band-gap sizes divided by their midgap frequencies) of 5.1% can be achieved. The general characteristics of the APSs are similar to those of the phononic crystals composed of two types of materials, with the main difference being the formation mechanism of the CPBGs, which originate from the couplings between lattice vibrations along two different directions and electromagnetic waves rather than from the periodical modulation of density and elastic constants. In addition, there are no lattice mismatches because the APSs are made of the same material. Thus, the APSs can also be extended to the construction of novel acousto-optic devices.

  8. Anisotropic mechanical properties of graphene sheets from molecular dynamics

    International Nuclear Information System (INIS)

    Ni Zhonghua; Bu Hao; Zou Min; Yi Hong; Bi Kedong; Chen Yunfei

    2010-01-01

    Anisotropic mechanical properties are observed for a sheet of graphene along different load directions. The anisotropic mechanical properties are attributed to the hexagonal structure of the unit cells of the graphene. Under the same tensile loads, the edge bonds bear larger load in the longitudinal mode (LM) than in the transverse mode (TM), which causes fracture sooner in LM than in TM. The Young's modulus and the third order elastic modulus for the LM are slightly larger than that for the TM. Simulation also demonstrates that, for both LM and TM, the loading and unloading stress-strain response curves overlap as long as the graphene is unloaded before the fracture point. This confirms that graphene sustains complete elastic and reversible deformation in the elongation process.

  9. Synthesis of borophenes: Anisotropic, two-dimensional boron polymorphs.

    Science.gov (United States)

    Mannix, Andrew J; Zhou, Xiang-Feng; Kiraly, Brian; Wood, Joshua D; Alducin, Diego; Myers, Benjamin D; Liu, Xiaolong; Fisher, Brandon L; Santiago, Ulises; Guest, Jeffrey R; Yacaman, Miguel Jose; Ponce, Arturo; Oganov, Artem R; Hersam, Mark C; Guisinger, Nathan P

    2015-12-18

    At the atomic-cluster scale, pure boron is markedly similar to carbon, forming simple planar molecules and cage-like fullerenes. Theoretical studies predict that two-dimensional (2D) boron sheets will adopt an atomic configuration similar to that of boron atomic clusters. We synthesized atomically thin, crystalline 2D boron sheets (i.e., borophene) on silver surfaces under ultrahigh-vacuum conditions. Atomic-scale characterization, supported by theoretical calculations, revealed structures reminiscent of fused boron clusters with multiple scales of anisotropic, out-of-plane buckling. Unlike bulk boron allotropes, borophene shows metallic characteristics that are consistent with predictions of a highly anisotropic, 2D metal. Copyright © 2015, American Association for the Advancement of Science.

  10. Anisotropic plasmons, excitons, and electron energy loss spectroscopy of phosphorene

    Science.gov (United States)

    Ghosh, Barun; Kumar, Piyush; Thakur, Anmol; Chauhan, Yogesh Singh; Bhowmick, Somnath; Agarwal, Amit

    2017-07-01

    In this article, we explore the anisotropic electron energy loss spectrum (EELS) in monolayer phosphorene based on ab initio time-dependent density-functional-theory calculations. Similarly to black phosphorus, the EELS of undoped monolayer phosphorene is characterized by anisotropic excitonic peaks for energies in the vicinity of the band gap and by interband plasmon peaks for higher energies. On doping, an additional intraband plasmon peak also appears for energies within the band gap. Similarly to other two-dimensional systems, the intraband plasmon peak disperses as ωpl∝√{q } in both the zigzag and armchair directions in the long-wavelength limit and deviates for larger wave vectors. The anisotropy of the long-wavelength plasmon intraband dispersion is found to be inversely proportional to the square root of the ratio of the effective masses: ωpl(q y ̂) /ωpl(q x ̂) =√{mx/my } .

  11. Interactions, strings and isotopies in higher order anisotropic superspaces

    CERN Document Server

    Vacaru, Sergiu Ion

    2001-01-01

    The monograph summarizes the author's results on the geometry of anholonomic and locally anisotropic interactions, published in J. Math. Phys., Nucl. Phys. B, Ann. Phys. (NY), JHEP, Rep. Math. Phys., Int. J. Theor. Phys. and in some former Soviet Union and Romanian scientific journals. The main subjects are in the theory of field interactions, strings and diffusion processes on spaces, superspaces and isospaces with higher order anisotropy and inhomogeneity. The approach proceeds by developing the concept of higher order anisotropic (super)space which unifies the logical and manthematical aspects of modern Kaluza--Klein theories and generalized Lagrange and Finsler geometry and leads to modeling of physical processes on higher order fiber (super)bundles provided with nonlinear and distinguished connections and metric structures. This book can be also considered as a pedagogical survey on the mentioned subjects.

  12. Timoshenko beam element with anisotropic cross-sectional properties

    DEFF Research Database (Denmark)

    Stäblein, Alexander; Hansen, Morten Hartvig

    2016-01-01

    Beam models are used for the aeroelastic time and frequency domain analysis of wind turbines due to their computational efficiency. Many current aeroelastic tools for the analysis of wind turbines rely on Timoshenko beam elements with classical crosssectional properties (EA, EI, etc.). Those cross......-sectional properties do not reflect the various couplings arising from the anisotropic behaviour of the blade material. A twonoded, three-dimensional Timoshenko beam element was therefore extended to allow for anisotropic cross-sectional properties. For an uncoupled beam, the resulting shape functions are identical...... to the original formulation. The new element was implemented into a co-rotational formulation and validated against natural frequencies and several static load cases of previous works....

  13. Anisotropic Friction of Wrinkled Graphene Grown by Chemical Vapor Deposition.

    Science.gov (United States)

    Long, Fei; Yasaei, Poya; Yao, Wentao; Salehi-Khojin, Amin; Shahbazian-Yassar, Reza

    2017-06-21

    Wrinkle structures are commonly seen on graphene grown by the chemical vapor deposition (CVD) method due to the different thermal expansion coefficient between graphene and its substrate. Despite the intensive investigations focusing on the electrical properties, the nanotribological properties of wrinkles and the influence of wrinkle structures on the wrinkle-free graphene remain less understood. Here, we report the observation of anisotropic nanoscale frictional characteristics depending on the orientation of wrinkles in CVD-grown graphene. Using friction force microscopy, we found that the coefficient of friction perpendicular to the wrinkle direction was ∼194% compare to that of the parallel direction. Our systematic investigation shows that the ripples and "puckering" mechanism, which dominates the friction of exfoliated graphene, plays even a more significant role in the friction of wrinkled graphene grown by CVD. The anisotropic friction of wrinkled graphene suggests a new way to tune the graphene friction property by nano/microstructure engineering such as introducing wrinkles.

  14. Driven Anisotropic Diffusion at Boundaries: Noise Rectification and Particle Sorting

    Science.gov (United States)

    Bo, Stefano; Eichhorn, Ralf

    2017-08-01

    We study the diffusive dynamics of a Brownian particle in the proximity of a flat surface under nonequilibrium conditions, which are created by an anisotropic thermal environment with different temperatures being active along distinct spatial directions. By presenting the exact time-dependent solution of the Fokker-Planck equation for this problem, we demonstrate that the interplay between anisotropic diffusion and hard-core interaction with the plain wall rectifies the thermal fluctuations and induces directed particle transport parallel to the surface, without any deterministic forces being applied in that direction. Based on current micromanipulation technologies, we suggest a concrete experimental setup to observe this novel noise-induced transport mechanism. We furthermore show that it is sensitive to particle characteristics, such that this setup can be used for sorting particles of different sizes.

  15. Dynamics of anisotropic power-law f( R) cosmology

    Science.gov (United States)

    Shamir, M. F.

    2016-12-01

    Modified theories of gravity have attracted much attention of the researchers in the recent years. In particular, the f( R) theory has been investigated extensively due to important f( R) gravity models in cosmological contexts. This paper is devoted to exploring an anisotropic universe in metric f( R) gravity. A locally rotationally symmetric Bianchi type I cosmological model is considered for this purpose. Exact solutions of modified field equations are obtained for a well-known f( R) gravity model. The energy conditions are also discussed for the model under consideration. The viability of the model is investigated via graphical analysis using the present-day values of cosmological parameters. The model satisfies null energy, weak energy, and dominant energy conditions for a particular range of the anisotropy parameter while the strong energy condition is violated, which shows that the anisotropic universe in f( R) gravity supports the crucial issue of accelerated expansion of the universe.

  16. Dirac directional emission in anisotropic zero refractive index photonic crystals.

    Science.gov (United States)

    He, Xin-Tao; Zhong, Yao-Nan; Zhou, You; Zhong, Zhi-Chao; Dong, Jian-Wen

    2015-08-14

    A certain class of photonic crystals with conical dispersion is known to behave as isotropic zero-refractive-index medium. However, the discrete building blocks in such photonic crystals are limited to construct multidirectional devices, even for high-symmetric photonic crystals. Here, we show multidirectional emission from low-symmetric photonic crystals with semi-Dirac dispersion at the zone center. We demonstrate that such low-symmetric photonic crystal can be considered as an effective anisotropic zero-refractive-index medium, as long as there is only one propagation mode near Dirac frequency. Four kinds of Dirac multidirectional emitters are achieved with the channel numbers of five, seven, eleven, and thirteen, respectively. Spatial power combination for such kind of Dirac directional emitter is also verified even when multiple sources are randomly placed in the anisotropic zero-refractive-index photonic crystal.

  17. Theoretical Investigation of Anisotropic Damping in Exchange Bias Systems

    Science.gov (United States)

    Farrar, Alison; Beik Mohammadi, Jamileh; Mewes, Tim; Mewes, Claudia

    An accurate description of the magnetization dynamics of exchange bias systems is essential for further development of computer read heads and STT-MRAM. There have been several theoretical predictions of an anisotropic Gilbert damping tensor, influenced by the symmetry of the crystal structure, in place of the scalar Gilbert damping parameter in the Landau-Lifshitz-Gilbert equation of motion. However, experimental confirmation is difficult as the anisotropy of the damping parameter is expected to be small for single crystals. We follow up on our experimental discovery of a strong unidirectional contribution to the relaxation of exchange bias systems by implementing an anisotropic damping tensor in our Matlab-based micromagnetics code M3. We present results for a damping tensor with unidirectional anisotropy with respect to the instantaneous orientation of the magnetization. NSF-CAREER No 1452670 and 0952929, UA Computer-Based Honors Program.

  18. Ultraviolet laser-induced voltage in anisotropic shale

    Science.gov (United States)

    Miao, Xinyang; Zhu, Jing; Li, Yizhang; Zhao, Kun; Zhan, Honglei; Yue, Wenzheng

    2018-01-01

    The anisotropy of shales plays a significant role in oil and gas exploration and engineering. Owing to various problems and limitations, anisotropic properties were seldom investigated by direct current resistivity methods. Here in this work, a 248 nm ultraviolet laser was employed to assess the anisotropic electrical response of a dielectric shale. Angular dependence of laser-induced voltages (V p) were obtained, with a data symmetry at the location of 180° and a ~62.2% V p anisotropy of the sample. The double-exponential functions have provided an explanation for the electrical field controlled carrier transportation process in horizontal and vertical directions. The results demonstrate that the combination of optics and electrical logging analysis (Opti-electrical Logging) is a promising technology for the investigation of unconventional reservoirs.

  19. Static anisotropic solutions in f(T) theory

    Energy Technology Data Exchange (ETDEWEB)

    Daouda, M.H.; Rodrigues, Manuel E. [Universidade Federal do Espirito Santo, Centro de Ciencias Exatas, Departamento de Fisica, Av. Fernando Ferrari s/n, Campus de Goiabeiras, CEP29075-910, Vitoria, ES (Brazil); Houndjo, M.J.S. [Universidade Federal da Bahia, Instituto de Fisica, Salvador, BA (Brazil)

    2012-02-15

    In previous work, we undertook to study static and anisotropic content in f(T) theory and obtained new spherically symmetric solutions considering a constant torsion and some particular conditions for the pressure. In this paper, still in the framework of f(T) theory, new spherically symmetric solutions are obtained, first considering the general case of an isotropic fluid and later the anisotropic content case in which the generalized conditions for the matter content are considered such that the energy density, the radial and tangential pressures depend on the algebraic f(T) and its derivative f{sub T} (T). Moreover, we obtain the algebraic function f(T) through the reconstruction method for two cases and also study a polytropic model for the stellar structure. (orig.)

  20. Newton–Hooke-type symmetry of anisotropic oscillators

    International Nuclear Information System (INIS)

    Zhang, P.M.; Horvathy, P.A.; Andrzejewski, K.; Gonera, J.; Kosiński, P.

    2013-01-01

    Rotation-less Newton–Hooke-type symmetry, found recently in the Hill problem, and instrumental for explaining the center-of-mass decomposition, is generalized to an arbitrary anisotropic oscillator in the plane. Conversely, the latter system is shown, by the orbit method, to be the most general one with such a symmetry. Full Newton–Hooke symmetry is recovered in the isotropic case. Star escape from a galaxy is studied as an application. -- Highlights: ► Rotation-less Newton–Hooke (NH) symmetry is generalized to an arbitrary anisotropic oscillator. ► The orbit method is used to find the most general case for rotation-less NH symmetry. ► The NH symmetry is decomposed into Heisenberg algebras based on chiral decomposition

  1. An anisotropic diffusion approximation to thermal radiative transfer

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, Seth R.; Larsen, Edward W., E-mail: sethrj@umich.edu, E-mail: edlarsen@umich.edu [Department of Nuclear Engineering and Radiological Sciences, University of Michigan, Ann Arbor, MI (United States)

    2011-07-01

    This paper describes an anisotropic diffusion (AD) method that uses transport-calculated AD coefficients to efficiently and accurately solve the thermal radiative transfer (TRT) equations. By assuming weak gradients and angular moments in the radiation intensity, we derive an expression for the radiation energy density that depends on a non-local function of the opacity. This nonlocal function is the solution of a transport equation that can be solved with a single steady-state transport sweep once per time step, and the function's second angular moment is the anisotropic diffusion tensor. To demonstrate the AD method's efficacy, we model radiation flow down a channel in 'flatland' geometry. (author)

  2. The boundary sources method with arbitrary order anisotropic scattering

    International Nuclear Information System (INIS)

    Gert Van den, Eynde; Beauwens, R.; Mund, E.

    2005-01-01

    The Boundary Sources Method (BSM) is an integral method for solving the one-speed neutron transport equation that makes capital out of the exact knowledge of a transport kernel for the classical geometries: planar, spherical and cylindrical. We have developed a slab (multi-region) BSM code that allows for arbitrary order anisotropic scattering. The basic ingredient of our method is the calculation of (angular moments of) infinite medium Green's functions. We have used the singular Eigen-expansion (SEE) method developed for anisotropic scattering by Mika and Case and have developed a robust and accurate method to calculate its two parts: the discrete and continuum spectrum. We use several one-dimensional neutron transport benchmarks to show its high accuracy. We have treated 3 types of problems: 2-cell (U-H 2 O) disadvantage factors, the Reed problem and an extreme scattering problem

  3. Statistical ensembles and molecular dynamics studies of anisotropic solids. II

    International Nuclear Information System (INIS)

    Ray, J.R.; Rahman, A.

    1985-01-01

    We have recently discussed how the Parrinello--Rahman theory can be brought into accord with the theory of the elastic and thermodynamic behavior of anisotropic media. This involves the isoenthalpic--isotension ensemble of statistical mechanics. Nose has developed a canonical ensemble form of molecular dynamics. We combine Nose's ideas with the Parrinello--Rahman theory to obtain a canonical form of molecular dynamics appropriate to the study of anisotropic media subjected to arbitrary external stress. We employ this isothermal--isotension ensemble in a study of a fcc→ close-packed structural phase transformation in a Lennard-Jones solid subjected to uniaxial compression. Our interpretation of the Nose theory does not involve a scaling of the time variable. This latter fact leads to simplifications when studying the time dependence of quantities

  4. Anisotropic models are unitary: A rejuvenation of standard quantum cosmology

    Science.gov (United States)

    Pal, Sridip; Banerjee, Narayan

    2016-12-01

    The present work proves that the folklore of the pathology of non-conservation of probability in quantum anisotropic models is wrong. It is shown in full generality that all operator ordering can lead to a Hamiltonian with a self-adjoint extension as long as it is constructed as a symmetric operator. It is indicated that the self-adjoint extension, however, is not unique and this non-uniqueness is suspected not to be a feature of anisotropic models only, in the sense that there exists operator orderings such that Hamiltonian for an isotropic homogeneous cosmological model does not have unique self-adjoint extension. For isotropic model, there is a special unique extension associated with quadratic form of Hamiltonian, i.e., a Friedrich's extension. Details of calculations are carried out for a Bianchi III model as an example.

  5. Anisotropic charged physical models with generalized polytropic equation of state

    Science.gov (United States)

    Nasim, A.; Azam, M.

    2018-01-01

    In this paper, we found the exact solutions of Einstein-Maxwell equations with generalized polytropic equation of state (GPEoS). For this, we consider spherically symmetric object with charged anisotropic matter distribution. We rewrite the field equations into simple form through transformation introduced by Durgapal (Phys Rev D 27:328, 1983) and solve these equations analytically. For the physically acceptability of these solutions, we plot physical quantities like energy density, anisotropy, speed of sound, tangential and radial pressure. We found that all solutions fulfill the required physical conditions. It is concluded that all our results are reduced to the case of anisotropic charged matter distribution with linear, quadratic as well as polytropic equation of state.

  6. Ballistic Anisotropic Magnetoresistance of Single-Atom Contacts.

    Science.gov (United States)

    Schöneberg, J; Otte, F; Néel, N; Weismann, A; Mokrousov, Y; Kröger, J; Berndt, R; Heinze, S

    2016-02-10

    Anisotropic magnetoresistance, that is, the sensitivity of the electrical resistance of magnetic materials on the magnetization direction, is expected to be strongly enhanced in ballistic transport through nanoscale junctions. However, unambiguous experimental evidence of this effect is difficult to achieve. We utilize single-atom junctions to measure this ballistic anisotropic magnetoresistance (AMR). Single Co and Ir atoms are deposited on domains and domain walls of ferromagnetic Fe layers on W(110) to control their magnetization directions. They are contacted with nonmagnetic tips in a low-temperature scanning tunneling microscope to measure the junction conductances. Large changes of the magnetoresistance occur from the tunneling to the ballistic regime due to the competition of localized and delocalized d-orbitals, which are differently affected by spin-orbit coupling. This work shows that engineering the AMR at the single atom level is feasible.

  7. Anisotropic to Isotropic Phase Transitions in the Early Universe

    Directory of Open Access Journals (Sweden)

    Ajaib M. A.

    2012-04-01

    Full Text Available We attempt to develop a minimal formalism to describe an anisotropic to isotropic tran- sition in the early Universe. Assuming an underlying theory that violates Lorentz in- variance, we start with a Dirac like equation, involving four massless fields, and which does not exhibit Lorentz invariance. We then perform transformations that restore it to its covariant form along with a mass term for the fermion field. It is proposed that these transformations can be visualized as waves traveling in an anisotropic media. The trans- formation it = ℏ ! is then utilized to transit to a statistical thermodynamics system and the partition function then gives a better insight into the character of this transition. The statistical system hence realized is a two level system with each state doubly degenerate. We propose that modeling the transition this way can help explain the matter antimatter asymmetry of the Universe.

  8. Holographic Fermions in Anisotropic Einstein-Maxwell-Dilaton-Axion Theory

    Directory of Open Access Journals (Sweden)

    Li-Qing Fang

    2015-01-01

    Full Text Available We investigate the properties of the holographic Fermionic system dual to an anisotropic charged black brane bulk in Einstein-Maxwell-Dilaton-Axion gravity theory. We consider the minimal coupling between the Dirac field and the gauge field in the bulk gravity theory and mainly explore the dispersion relation exponents of the Green functions of the dual Fermionic operators in the dual field theory. We find that along both the anisotropic and the isotropic directions the Fermi momentum will be effected by the anisotropy of the bulk theory. However, the anisotropy has influence on the dispersion relation which is almost linear for massless Fermions with charge q=2. The universal properties that the mass and the charge of the Fermi possibly correspond to nonlinear dispersion relation are also investigated.

  9. Life prediction and constitutive models for anisotropic materials

    Science.gov (United States)

    Bill, R. C.

    1982-01-01

    The intent of this program is to develop a basic understanding of cyclic creep-fatigue deformation mechanisms and damage accumulation, a capability for reliable life prediction, and the ability to model the constitutive behavior of anisotropic single crystal (SC) and directionally solidified or recrystallized (DSR) comprise the program, and the work breakdown for each option reflects a distinct concern for two classes of anisotropic materials, SC and DSR materials, at temperatures encountered in the primary gas path (airfoil temperatures), and at temperatures typical of the blade root attachment and shank area. Work directed toward the higher temperature area of concern in the primary gas path includes effects of coatings on the behavior and properties of the materials of interest. The blade root attachment work areas will address the effects of stress concentrations associated with attachment features.

  10. Theory for propulsion and transport in an anisotropic fluid

    Science.gov (United States)

    Powers, Thomas; Krieger, Madison; Spagnolie, Saverio

    2013-11-01

    Swimming microorganisms are typically found in complex fluids, which are full of polymers. When these polymers align, the fluid becomes anisotropic. We seek to understand how anisotropy affects swimming when the stroke is prescribed. We model the anisotropic fluid with a nematic liquid crystal. The swimmer is a two-dimensional sheet deforming via propagating transverse or longitudinal waves. We find that the nature of anchoring conditions for the nematic degrees of freedom plays a critical role in determining the swimming speed. Furthermore, we study the fluid transport induced by the swimmers motion by calculating the flux of fluid in the laboratory frame. Finally, we elucidate the various limits of the nematic theory, such as the six-fold symmetric hexatic case and Ericksen's transversely isotropic fluid.

  11. Independent regulation of reovirus membrane penetration and apoptosis by the mu1 phi domain.

    Directory of Open Access Journals (Sweden)

    Pranav Danthi

    2008-12-01

    Full Text Available Apoptosis plays an important role in the pathogenesis of reovirus encephalitis. Reovirus outer-capsid protein mu1, which functions to penetrate host cell membranes during viral entry, is the primary regulator of apoptosis following reovirus infection. Ectopic expression of full-length and truncated forms of mu1 indicates that the mu1 phi domain is sufficient to elicit a cell death response. To evaluate the contribution of the mu1 phi domain to the induction of apoptosis following reovirus infection, phi mutant viruses were generated by reverse genetics and analyzed for the capacity to penetrate cell membranes and elicit apoptosis. We found that mutations in phi diminish reovirus membrane penetration efficiency by preventing conformational changes that lead to generation of key reovirus entry intermediates. Independent of effects on membrane penetration, amino acid substitutions in phi affect the apoptotic potential of reovirus, suggesting that phi initiates apoptosis subsequent to cytosolic delivery. In comparison to wild-type virus, apoptosis-defective phi mutant viruses display diminished neurovirulence following intracranial inoculation of newborn mice. These results indicate that the phi domain of mu1 plays an important regulatory role in reovirus-induced apoptosis and disease.

  12. Pseudorapidity Dependence of Anisotropic Azimuthal Flow with the ALICE Detector

    DEFF Research Database (Denmark)

    Hansen, Alexander Colliander

    In ultra-relativistic heavy-ion collisions a new state of matter known as the strongly interacting quark-gluon plasma (sQGP) is produced. A key observable in the study of the sQGP is anisotropic azimuthal ow. The anisotropies are described by ow harmonics, vn. In this thesis, bias arising from no...... Detector and Silicon Pixel Detector at the CERN Large Hadron Collider (LHC). The results are compared to other LHC experiments andprevious experiments at lower collision energies....

  13. Wave propagation in layered anisotropic media with application to composites

    CERN Document Server

    Nayfeh, AH

    1995-01-01

    Recent advances in the study of the dynamic behavior of layered materials in general, and laminated fibrous composites in particular, are presented in this book. The need to understand the microstructural behavior of such classes of materials has brought a new challenge to existing analytical tools. This book explores the fundamental question of how mechanical waves propagate and interact with layered anisotropic media. The chapters are organized in a logical sequence depending upon the complexity of the physical model and its mathematical treatment.

  14. The second critical density and anisotropic generalised condensation

    Directory of Open Access Journals (Sweden)

    M. Beau

    2010-01-01

    Full Text Available In this letter we discuss the relevance of the 3D Perfect Bose gas (PBG condensation in extremely elongated vessels for the study of anisotropic condensate coherence and the "quasi-condensate". To this end we analyze the case of exponentially anisotropic (van den Berg boxes, when there are two critical densities ρc<ρm for a generalised Bose-Einstein Condensation (BEC. Here ρc is the standard critical density for the PBG. We consider three examples of anisotropic geometry: slabs, squared beams and "cigars" to demonstrate that the "quasi-condensate" which exists in domain ρc<ρ<ρm is in fact the van den Berg-Lewis-Pulé generalised condensation (vdBLP-GC of the type III with no macroscopic occupation of any mode. We show that for the slab geometry the second critical density ρm is a threshold between quasi-two-dimensional (quasi-2D condensate and the three dimensional (3D regime when there is a coexistence of the "quasi-condensate" with the standard one-mode BEC. On the other hand, in the case of squared beams and "cigars" geometries, critical density ρm separates quasi-1D and 3D regimes. We calculate the value of the difference between ρc, ρm (and between corresponding critical temperatures Tm, Tc to show that the observed space anisotropy of the condensate coherence can be described by a critical exponent γ(T related to the anisotropic ODLRO. We compare our calculations with physical results for extremely elongated traps that manifest "quasi-condensate".

  15. Theoretical assessment of sound absorption coefficient for anisotropic nonwovens

    OpenAIRE

    Klara Kalinova

    2012-01-01

    The anisotropy factor as a function of fiber arrangement, fiber fineness and sample thickness has been derived from the theories of soundwave transformation due to phase changing. The sound absorption coefficient of the anisotropic fibrous material is then theoretically calculated. The fibrous materials were prepared so that the fibers are arranged parallel (perpendicularly laid fiber web called STRUTO technology) in the direction of soundwave propagation or perpendicularly (longitudinally la...

  16. Existence of longitudinal waves in pre-stressed anisotropic elastic ...

    Indian Academy of Sciences (India)

    In the absence of pre-stresses, i.e., taking. S11 = S22 = S33 = 0, all the expressions, derived in this section, will reduce to the results which are same as in Ting (2006). 4. Triclinic materials. A triclinic material is the most general anisotropic medium, and the elastic compliance b11(N) in this medium is as defined by equation ...

  17. Anisotropic static solutions in modelling highly compact bodies

    Indian Academy of Sciences (India)

    x2µ(x)dx which is the mass function. The radial pressure pr = p + 2S/. √. 3 and the tangential pressure p⊥ = p − S/. √. 3 are not equal for anisotropic matter. The magnitude S provides a measure of anisotropy. The field equations (1)–(3) were integrated by Chaisi and Maharaj [12] for the energy density. µ = j r2. + k + lr2,. (4).

  18. Charged anisotropic star on paraboloidal space-time

    Indian Academy of Sciences (India)

    dr2 − r2 ( dθ2 + sin2 θdφ2). ,. (1) with the energy–momentum tensor for anisotropic charged fluid,. Tij = diag. ( ρ + E2, pr − E2, pt + E2, pt + E2). ,. (2) where ρ is the energy density, pr is the radial pressure, pt is the tangential pressure and. E is the electric field intensity. These quantities are measured relative to the comoving.

  19. Anisotropic shift of the irreversibility line by neutron irradiation

    International Nuclear Information System (INIS)

    Sauerzopf, F.M.; Wiesinger, H.P.; Weber, H.W.; Crabtree, G.W.; Frischherz, M.C.; Kirk, M.A.

    1991-09-01

    The irreversibility line of high-T c superconductors is shifted considerably by irradiating the material with fast neutrons. The anisotropic and non-monotonous shift is qualitatively explained by a simple model based on an interaction between three pinning mechanisms, the intrinsic pinning by the ab-planes, the weak pinning by the pre-irradiation defect structure, and strong pinning by neutron induced defect cascades. A correlation between the cascade density and the position of the irreversibility line is observed

  20. Efficient light propagation for multiple anisotropic volume scattering

    Energy Technology Data Exchange (ETDEWEB)

    Max, N. [Lawrence Livermore National Lab., CA (United States)]|[California Univ., Davis, CA (United States)

    1993-12-01

    Realistic rendering of participating media like clouds requires multiple anisotropic light scattering. This paper presents a propagation approximation for light scattered into M direction bins, which reduces the ``ray effect`` problem in the traditional ``discrete ordinates`` method. For a volume of n{sup 3} elements, it takes O(M n{sup 3} log n + M{sup 2} n{sup 3}) time and O(M n{sup 3}) space.

  1. Circumferential gap propagation in an anisotropic elastic bacterial sacculus

    OpenAIRE

    Taneja, Swadhin; Levitan, Benjamin A.; Rutenberg, Andrew D.

    2013-01-01

    We have modelled stress concentration around small gaps in anisotropic elastic sheets, corresponding to the peptidoglycan sacculus of bacterial cells, under loading corresponding to the effects of turgor pressure in rod-shaped bacteria. We find that under normal conditions the stress concentration is insufficient to mechanically rupture bacteria, even for gaps up to a micron in length. We then explored the effects of stress-dependent smart-autolysins, as hypothesised by Arthur L Koch [Advance...

  2. Model and calculation of in situ stresses in anisotropic formations

    Energy Technology Data Exchange (ETDEWEB)

    Yuezhi, W.; Zijun, L.; Lixin, H. [Jianghan Petroleum Institute, (China)

    1997-08-01

    In situ stresses in transversely isotropic material in relation to wellbore stability have been investigated. Equations for three horizontal in- situ stresses and a new formation fracture pressure model were described, and the methodology for determining the elastic parameters of anisotropic rocks in the laboratory was outlined. Results indicate significantly smaller differences between theoretically calculated pressures and actual formation pressures than results obtained by using the isotropic method. Implications for improvements in drilling efficiency were reviewed. 13 refs., 6 figs.

  3. Anisotropic square lattice Potts ferromagnet: renormalization group treatment

    International Nuclear Information System (INIS)

    Oliveira, P.M.C. de; Tsallis, C.

    1981-01-01

    The choice of a convenient self-dual cell within a real space renormalization group framework enables a satisfactory treatment of the anisotropic square lattice q-state Potts ferromagnet criticality. The exact critical frontier and dimensionality crossover exponent PHI as well as the expected universality behaviour (renormalization flow sense) are recovered for any linear scaling factor b and all values of q(q - [pt

  4. Anisotropic magnetoresistance of GaMnAs ferromagnetic semiconductors

    Czech Academy of Sciences Publication Activity Database

    Vašek, Petr; Svoboda, Pavel; Novák, Vít; Cukr, Miroslav; Výborný, Karel; Jurka, Vlastimil; Stuchlík, Jiří; Orlita, Milan; Maude, D. K.

    2010-01-01

    Roč. 23, č. 6 (2010), 1161-1163 ISSN 1557-1939 R&D Projects: GA AV ČR KAN400100652; GA MŠk MEB020928 Grant - others:EU EuroMagNET II(XE) Egide 19535NF Institutional research plan: CEZ:AV0Z10100521 Keywords : GaMnAs * anisotropic magnetoresistance * hydrogenation Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 1.014, year: 2010

  5. LIGHT ABERRATION IN OPTICAL ANISOTROPIC SINGLE-AXIS MEDIUM

    Directory of Open Access Journals (Sweden)

    V. M. Svishch

    2017-10-01

    Full Text Available The entrainment of the light flux by a uniaxial anisotropic medium and its influence on the measurement of stellar aberration are analyzed. The influence of the entrainment of the light flux by an isotropic medium on the measurement of stellar aberration was considered by Fresnel early. The absence of such influence was confirmed by Erie's experience when filling the telescope tube with water. The formula itself was perfectly confirmed by Fizeau's experiments with moving water and the repetition of this experiment with an increase in the accuracy of measurements by Michelson, Zeeman, and others. G.A. Lorentz already on the basis of the electromagnetic theory specified the formula with allowance for the frequency dispersion of the light flux. A. Einstein made an analysis of the schemes of experiments for determining the drag coefficient, covering all possible variants of similar experiments. As a result, he obtained Fresnel and Lorentz formulas, taking into account the frequency dispersion of light, starting from the theory of relativity. The entrainment of light and its influence on the measurement of stellar aberration by a uniaxial anisotropic medium have not been considered anywhere. An analysis of such influence is carried out. The results of the analysis indicate the possibility of measuring the current value of stellar aberration using a uniaxial anisotropic medium. The concept of active light aberration is introduced. The proposed schemes of experiments of using the entrainment of a light flux by an anisotropic substance for measuring the current value of stellar aberration are investigated. It is concluded that it is possible to study the determination of the current velocity of an inertial system relative to the light flux.

  6. Jones phase microscopy of transparent and anisotropic samples.

    Science.gov (United States)

    Wang, Zhuo; Millet, Larry J; Gillette, Martha U; Popescu, Gabriel

    2008-06-01

    We developed an interferometric microscopy technique, referred to as Jones phase microscopy, capable of extracting the spatially resolved Jones polarization matrix associated with transparent and anisotropic samples. This is a generalization of quantitative phase imaging, which is recovered from one diagonal element of the measured matrix. The principle of the technique is demonstrated with measurements of a liquid crystal spatial light modulator and the potential for live cell imaging with experiments on live neurons in culture.

  7. Pseudorapidity Dependence of Anisotropic Azimuthal Flow with the ALICE Detector

    DEFF Research Database (Denmark)

    Hansen, Alexander Colliander

    In ultra-relativistic heavy-ion collisions a new state of matter known as the strongly interacting quark-gluon plasma (sQGP) is produced. A key observable in the study of the sQGP is anisotropic azimuthal ow. The anisotropies are described by ow harmonics, vn. In this thesis, bias arising from non...... Detector and Silicon Pixel Detector at the CERN Large Hadron Collider (LHC). The results are compared to other LHC experiments andprevious experiments at lower collision energies....

  8. Rational synthesis and self-assembly of anisotropic plasmonic nanoparticles

    OpenAIRE

    Scarabelli, Leonardo

    2016-01-01

    This thesis work has been carried out in the framework of the ERC Advanced Grant Plasmaquo (nº 267867), which focused on the development of novel nanostructured plasmonic materials based on crystalline assemblies of anisotropic nanoparticles, to be used as optical enhancers for the surface enhanced Raman scattering detection of bacterial Quorum Sensing signaling molecules. More specifically, the thesis was oriented toward the design of such nanostructures, and on the characterization of their...

  9. Anisotropic expansion of a thermal dipolar Bose gas

    OpenAIRE

    Tang, Yijun; Sykes, Andrew G.; Burdick, Nathaniel Q.; DiSciacca, Jack M.; Petrov, Dmitry S.; Lev, Benjamin L.

    2016-01-01

    We report on the anisotropic expansion of ultracold bosonic dysprosium gases at temperatures above quantum degeneracy and develop a quantitative theory to describe this behavior. The theory expresses the post-expansion aspect ratio in terms of temperature and microscopic collisional properties by incorporating Hartree-Fock mean-field interactions, hydrodynamic effects, and Bose-enhancement factors. Our results extend the utility of expansion imaging by providing accurate thermometry for dipol...

  10. Effect of initial stress on reflection at the free surface of anisotropic ...

    Indian Academy of Sciences (India)

    The Snell's Law for such a medium ensures that the phase directions of all these waves lie in the same vertical plane, i.e.,. (p1, p2) is same for all the waves. The six waves differ in vertical component (i.e., p3) of slowness vector. So, for a given incident wave, p1 and p2 are known but the vertical slowness p3 of a wave at.

  11. Modeling Anisotropic Elastic Wave Propagation in Jointed Rock Masses

    Science.gov (United States)

    Hurley, R.; Vorobiev, O.; Ezzedine, S. M.; Antoun, T.

    2016-12-01

    We present a numerical approach for determining the anisotropic stiffness of materials with nonlinearly-compliant joints capable of sliding. The proposed method extends existing ones for upscaling the behavior of a medium with open cracks and inclusions to cases relevant to natural fractured and jointed rocks, where nonlinearly-compliant joints can undergo plastic slip. The method deviates from existing techniques by incorporating the friction and closure states of the joints, and recovers an anisotropic elastic form in the small-strain limit when joints are not sliding. We present the mathematical formulation of our method and use Representative Volume Element (RVE) simulations to evaluate its accuracy for joint sets with varying complexity. We then apply the formulation to determine anisotropic elastic constants of jointed granite found at the Nevada Nuclear Security Site (NNSS) where the Source Physics Experiments (SPE), a campaign of underground chemical explosions, are performed. Finally, we discuss the implementation of our numerical approach in a massively parallel Lagrangian code Geodyn-L and its use for studying wave propagation from underground explosions. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

  12. Investigation of Anisotropic Bonded Magnets in Permanent Magnet Machine Applications

    Science.gov (United States)

    Khazdozian, H. A.; McCall, S. K.; Kramer, M. J.; Paranthaman, M. P.; Nlebedim, I. C.

    Rare earth elements (REE) provide the high energy product necessary for permanent magnets, such as sintered Nd2Fe14B, in many applications like wind energy generators. However, REEs are considered critical materials due to risk in their supply. To reduce the use of critical materials in permanent magnet machines, the performance of anisotropic bonded NdFeB magnets, aligned under varying magnetic field strength, was simulated using 3D finite element analysis in a 3MW direct-drive permanent magnet generator (DDPMG), with sintered N42 magnets used as a baseline for comparison. For direct substitution of the anisotropic bonded magnets, approximately 85% of the efficiency of the baseline model was achieved, irrespective of the alignment field. The torque and power generation of the DDPMG was not found to vary significantly with increase in the alignment field. Finally, design changes were studied to allow for the achievement of rated torque and power with the use of anisotropic bonded magnets, demonstrating the potential for reduction of critical materials in permanent magnets for renewable energy applications. This work was supported by the Critical Materials Institute, an Energy Innovation Hub funded by the U.S. Department of Energy, Office of Energy Efficiency and Renewable Energy, Advanced Manufacturing Office.

  13. Efficient anisotropic wavefield extrapolation using effective isotropic models

    KAUST Repository

    Alkhalifah, Tariq Ali

    2013-06-10

    Isotropic wavefield extrapolation is more efficient than anisotropic extrapolation, and this is especially true when the anisotropy of the medium is tilted (from the vertical). We use the kinematics of the wavefield, appropriately represented in the high-frequency asymptotic approximation by the eikonal equation, to develop effective isotropic models, which are used to efficiently and approximately extrapolate anisotropic wavefields using the isotropic, relatively cheaper, operators. These effective velocity models are source dependent and tend to embed the anisotropy in the inhomogeneity. Though this isotropically generated wavefield theoretically shares the same kinematic behavior as that of the first arrival anisotropic wavefield, it also has the ability to include all the arrivals resulting from a complex wavefield propagation. In fact, the effective models reduce to the original isotropic model in the limit of isotropy, and thus, the difference between the effective model and, for example, the vertical velocity depends on the strength of anisotropy. For reverse time migration (RTM), effective models are developed for the source and receiver fields by computing the traveltime for a plane wave source stretching along our source and receiver lines in a delayed shot migration implementation. Applications to the BP TTI model demonstrates the effectiveness of the approach.

  14. Stochastic self-propagating star formation with anisotropic probability distribution

    Science.gov (United States)

    Jungwiert, B.; Palous, J.

    1994-07-01

    We present a 2D computer code for stochastic self-propagating star formation (SSPSF) in differentially rotating galaxies. The isotropic probability distribution, used in previous models of Seiden, Gerola and Schulman (Seiden & Schulman, 1990, and references therein), is replaced by an anisotropic one. The motivation is provided by models of expanding large-scale supernova remnants (SNR) in disks with shear (Palous et al. 1990): the distortion of the SNR leads to uneven density distribution along its periphery and, consequently, to uneven distribution of new star forming sites. To model anisotropic SSPSF, we process in two steps: first, we eliminate artificial anisotropies inherent to the technique used by Seiden, Gerola and Schulman and, second, we define the probability ellipse on each star forming site. The anisotropy is characterized by its axes ratio and inclination with respect to the galactic center. We show that anisotropic SSPSF is able to produce highly organized spiral structures. Depending on the character of the probability ellipse, we can obtain continous spiral arms of different length, thickness and pitch angle. The relation of the probability ellipse to rotation curves interstellar medium (ISM) density and metallicity is discussed as well as its variation along the Hubble sequence and van den Bergh's luminosity classification of galaxies. To demonstrate applications, we compare our results with two different classes of galaxies: M 101-type grand-design spirals with open and robust arms and NGC 2841-type flocculent galaxies with thin and tightly wound arms.

  15. Anisotropic fluid spheres of embedding class one using Karmarkar condition

    Energy Technology Data Exchange (ETDEWEB)

    Maurya, S.K. [University of Nizwa, Department of Mathematical and Physical Sciences, College of Arts and Science, Nizwa (Oman); Maharaj, S.D. [School of Mathematics, Statistics and Computer Science, University of KwaZulu-Natal, Astrophysics and Cosmology Research Unit, Private Bag X54001, Durban (South Africa)

    2017-05-15

    We obtain a new anisotropic solution for spherically symmetric spacetimes by analyzing the Karmarkar embedding condition. For this purpose we construct a suitable form of one of the gravitational potentials to obtain a closed form solution. This form of the remaining gravitational potential allows us to solve the embedding equation and integrate the field equations. The resulting new anisotropic solution is well behaved, which can be utilized to construct realistic static fluid spheres. Also we estimated the masses and radii of fluid spheres for LMC X-4, EXO 1785-248, PSR J1903+327 and 4U 1820-30 by using observational data set values. The masses and radii obtained show that our anisotropic solution can represent fluid spheres to a very good degree of accuracy. The physical validity of the solution depends on the parameter values of a, b and c. The solution is well behaved for the wide range of parameters values 0.00393 ≤ a ≤ 0.0055, 0.0002 ≤ b ≤ 0.0025 and 0.0107 ≤ c ≤ 0.0155. The range of corresponding physical parameters for the different compact stars are 0.3266 ≤ v{sub r0} ≤ 0.3708, 0.1583 ≤ v{sub t0} ≤ 0.2558, 0.3256 ≤ z{sub s} ≤ 0.4450 and 4.3587 ≤ Γ{sub 0} ≤ 5.6462. (orig.)

  16. Pattern formation of a nonlocal, anisotropic interaction model

    KAUST Repository

    Burger, Martin

    2017-11-24

    We consider a class of interacting particle models with anisotropic, repulsive–attractive interaction forces whose orientations depend on an underlying tensor field. An example of this class of models is the so-called Kücken–Champod model describing the formation of fingerprint patterns. This class of models can be regarded as a generalization of a gradient flow of a nonlocal interaction potential which has a local repulsion and a long-range attraction structure. In contrast to isotropic interaction models the anisotropic forces in our class of models cannot be derived from a potential. The underlying tensor field introduces an anisotropy leading to complex patterns which do not occur in isotropic models. This anisotropy is characterized by one parameter in the model. We study the variation of this parameter, describing the transition between the isotropic and the anisotropic model, analytically and numerically. We analyze the equilibria of the corresponding mean-field partial differential equation and investigate pattern formation numerically in two dimensions by studying the dependence of the parameters in the model on the resulting patterns.

  17. Tuning particle geometry of chemically anisotropic dumbbell-shaped colloids.

    Science.gov (United States)

    van Ravensteijn, Bas G P; Kegel, Willem K

    2017-03-15

    Chemically anisotropic dumbbell-shaped colloids are prepared starting from cross-linked polymer seed particles coated with a chlorinated outer layer. These chlorinated seeds are swollen with monomer. Subsequently, a liquid protrusion is formed on the surface of the seed particle by phase separation between the monomer and the swollen polymer network. Solidification of these liquid lobes by polymerization leads to the desired dumbbell-shaped colloids. The chlorine groups remain confined on the seed lobe of the particles, ensuring chemical anisotropy of the resulting particles. Exploiting the asymmetric distribution of the chemically reactive surface chlorine groups allows for site-specific surface modifications. Here we show that the geometry of the resulting chemically anisotropic dumbbells can be systematically tuned by a number of experimental parameters including the volume of styrene by which the seeds are swollen, the cross-link density of the chlorinated seeds and chemical composition/thickness of the chlorinated coating deposited on the seed particles. Being able to control the particle geometry, and therefore the Janus balance of these chemically anisotropic particles, provides a promising starting point for the synthesis of sophisticated building blocks for future (self-assembly) studies. Copyright © 2016 Elsevier Inc. All rights reserved.

  18. Anisotropic silk fibroin/gelatin scaffolds from unidirectional freezing

    Energy Technology Data Exchange (ETDEWEB)

    Asuncion, Maria Christine Tankeh, E-mail: christine.asuncion@u.nus.edu [National University of Singapore, Department of Biomedical Engineering (Singapore); Goh, James Cho-Hong [National University of Singapore, Department of Biomedical Engineering (Singapore); National University of Singapore, Department of Orthopedic Surgery (Singapore); Toh, Siew-Lok [National University of Singapore, Department of Biomedical Engineering (Singapore); National University of Singapore, Department of Mechanical Engineering (Singapore)

    2016-10-01

    Recent studies have underlined the importance of matching scaffold properties to the biological milieu. Tissue, and thus scaffold, anisotropy is one such property that is important yet sometimes overlooked. Methods that have been used to achieve anisotropic scaffolds present challenges such as complicated fabrication steps, harsh processing conditions and toxic chemicals involved. In this study, unidirectional freezing was employed to fabricate anisotropic silk fibroin/gelatin scaffolds in a simple and mild manner. Morphological, mechanical, chemical and cellular compatibility properties were investigated, as well as the effect of the addition of gelatin to certain properties of the scaffold. It was shown that scaffold properties were suitable for cell proliferation and that mesenchymal stem cells were able to align themselves along the directed fibers. The fabricated scaffolds present a platform that can be used for anisotropic tissue engineering applications such as cardiac patches. - Highlights: • Silk/gelatin scaffolds with unidirectional alignment were fabricated using a simple and scalable process • Presence of gelatin in silk resulted to lesser shrinkage, better water retention and improved cell proliferation. • Mesenchymal stem cells were shown to align themselves according to the fiber alignment.

  19. Nanoparticle-Structured Highly Sensitive and Anisotropic Gauge Sensors.

    Science.gov (United States)

    Zhao, Wei; Luo, Jin; Shan, Shiyao; Lombardi, Jack P; Xu, Yvonne; Cartwright, Kelly; Lu, Susan; Poliks, Mark; Zhong, Chuan-Jian

    2015-09-16

    The ability to tune gauge factors in terms of magnitude and orientation is important for wearable and conformal electronics. Herein, a sensor device is described which is fabricated by assembling and printing molecularly linked thin films of gold nanoparticles on flexible microelectrodes with unusually high and anisotropic gauge factors. A sharp difference in gauge factors up to two to three orders of magnitude between bending perpendicular (B(⊥)) and parallel (B(||)) to the current flow directions is observed. The origin of the unusual high and anisotropic gauge factors is analyzed in terms of nanoparticle size, interparticle spacing, interparticle structure, and other parameters, and by considering the theoretical aspects of electron conduction mechanism and percolation pathway. A critical range of resistivity where a very small change in strain and the strain orientation is identified to impact the percolation pathway in a significant way, leading to the high and anisotropic gauge factors. The gauge anisotropy stems from molecular and nanoscale fine tuning of interparticle properties of molecularly linked nanoparticle assembly on flexible microelectrodes, which has important implication for the design of gauge sensors for highly sensitive detection of deformation in complex sensing environment or on complex curved surfaces such as wearable electronics and skin sensors. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  20. Sound localization in an anisotropic plate using electret microphones.

    Science.gov (United States)

    Hoseini Sabzevari, S Amir; Moavenian, Majid

    2017-01-01

    Acoustic source localization without knowing the velocity profile in anisotropic plates is still one of the most challenging areas in this field. The current time-of-flight based approaches for localization in anisotropic media, are based on using six high sampling sensors. The number of sensors and the corresponding large amount of data, would make those methods inefficient in practical applications. Although there are many different non-time-of-flight based approaches such as machine learning, or soft computing based methods that can be used for localization with a less number of sensors, they are not as accurate as time-of-flight based techniques. In this article, a new approach which requires only four low sampling rate sensors to localize acoustic source in an anisotropic plate is proposed. In this technique, four electret low sampling rate sensors in two clusters are installed on the plate surface. The presented method uses attenuation analysis in a suitable frequency band to decrease the number of sensors. The approach is experimentally tested and verified on an airplane composite nose by applying artificially generated acoustic emissions (Hsu-Nielsen source). The results reveal that the accuracy of proposed technique depends on distinction of dominant frequency band. A stethoscope as a physical filter is employed to reduce the sensitivity of the technique and delineation of frequency band. The suggested technique improves the accuracy of localization prediction. Copyright © 2016 Elsevier B.V. All rights reserved.

  1. Overview of thermal conductivity models of anisotropic thermal insulation materials

    Science.gov (United States)

    Skurikhin, A. V.; Kostanovsky, A. V.

    2017-11-01

    Currently, the most of existing materials and substances under elaboration are anisotropic. It makes certain difficulties in the study of heat transfer process. Thermal conductivity of the materials can be characterized by tensor of the second order. Also, the parallelism between the temperature gradient vector and the density of heat flow vector is violated in anisotropic thermal insulation materials (TIM). One of the most famous TIM is a family of integrated thermal insulation refractory material («ITIRM»). The main component ensuring its properties is the «inflated» vermiculite. Natural mineral vermiculite is ground into powder state, fired by gas burner for dehydration, and its precipitate is then compressed. The key feature of thus treated batch of vermiculite is a package structure. The properties of the material lead to a slow heating of manufactured products due to low absorption and high radiation reflection. The maximum of reflection function is referred to infrared spectral region. A review of current models of heat propagation in anisotropic thermal insulation materials is carried out, as well as analysis of their thermal and optical properties. A theoretical model, which allows to determine the heat conductivity «ITIRM», can be useful in the study of thermal characteristics such as specific heat capacity, temperature conductivity, and others. Materials as «ITIRM» can be used in the metallurgy industry, thermal energy and nuclear power-engineering.

  2. Surface waves in an heterogeneous anisotropic continental lithosphere

    Science.gov (United States)

    Maupin, V.

    2003-04-01

    At global as well as at regional scale, the lithosphere appears usually faster to Love waves than to Rayleigh waves. This Love-Rayleigh discrepancy can be modelled by introducing transverse isotropy in the mantle. In continental structures, the amount of transverse isotropy necessary to explain the discrepancy is however often quite large and not compatible with results of SKS-splitting analysis and azimuthal variation of surface wave velocities, at least in the simple framework of large scale uniform olivine orientation in the continental lithosphere. Models where the orientation of the olivine is incoherent at the scale of a few hundred km have been proposed to reconcile the different datasets, but the surface wave characteristics in such anisotropic heterogeneous models have not yet been analysed in detail. Using a mode-coupling scheme for calculating surface wave propagation in heterogeneous anisotropic structures, we analyse the characteristics of Rayleigh and Love waves in such laterally varying anisotropic models. We generate 3-D stochastic models of olivine orientation with different characteristics: preferred orientation dominantly horizontal, vertical or equally distributed in all directions, and use different correlation lengths in the horizontal and vertical directions to constrain the scale at which the anisotropy is coherent. We analyse the apparent Love-Rayleigh discrepancy and the phase velocity azimuthal variation these models generate and the mode-coupling and polarisation anomalies they produce.

  3. Isothermal anisotropic magnetoresistance in antiferromagnetic metallic IrMn.

    Science.gov (United States)

    Galceran, R; Fina, I; Cisneros-Fernández, J; Bozzo, B; Frontera, C; López-Mir, L; Deniz, H; Park, K-W; Park, B-G; Balcells, Ll; Martí, X; Jungwirth, T; Martínez, B

    2016-10-20

    Antiferromagnetic spintronics is an emerging field; antiferromagnets can improve the functionalities of ferromagnets with higher response times, and having the information shielded against external magnetic field. Moreover, a large list of aniferromagnetic semiconductors and metals with Néel temperatures above room temperature exists. In the present manuscript, we persevere in the quest for the limits of how large can anisotropic magnetoresistance be in antiferromagnetic materials with very large spin-orbit coupling. We selected IrMn as a prime example of first-class moment (Mn) and spin-orbit (Ir) combination. Isothermal magnetotransport measurements in an antiferromagnetic-metal(IrMn)/ferromagnetic-insulator thin film bilayer have been performed. The metal/insulator structure with magnetic coupling between both layers allows the measurement of the modulation of the transport properties exclusively in the antiferromagnetic layer. Anisotropic magnetoresistance as large as 0.15% has been found, which is much larger than that for a bare IrMn layer. Interestingly, it has been observed that anisotropic magnetoresistance is strongly influenced by the field cooling conditions, signaling the dependence of the found response on the formation of domains at the magnetic ordering temperature.

  4. Anisotropic diffusion of volatile pollutants at air-water interface

    Directory of Open Access Journals (Sweden)

    Li-ping Chen

    2013-04-01

    Full Text Available The volatile pollutants that spill into natural waters cause water pollution. Air pollution arises from the water pollution because of volatilization. Mass exchange caused by turbulent fluctuation is stronger in the direction normal to the air-water interface than in other directions due to the large density difference between water and air. In order to explore the characteristics of anisotropic diffusion of the volatile pollutants at the air-water interface, the relationship between velocity gradient and mass transfer rate was established to calculate the turbulent mass diffusivity. A second-order accurate smooth transition differencing scheme (STDS was proposed to guarantee the boundedness for the flow and mass transfer at the air-water interface. Simulations and experiments were performed to study the trichloroethylene (C2HCl3 release. By comparing the anisotropic coupling diffusion model, isotropic coupling diffusion model, and non-coupling diffusion model, the features of the transport of volatile pollutants at the air-water interface were determined. The results show that the anisotropic coupling diffusion model is more accurate than the isotropic coupling diffusion model and non-coupling diffusion model. Mass transfer significantly increases with the increase of the air-water relative velocity at a low relative velocity. However, at a higher relative velocity, an increase in the relative velocity has no effect on mass transfer.

  5. Surface Waves Propagating on Grounded Anisotropic Dielectric Slab

    Directory of Open Access Journals (Sweden)

    Zhuozhu Chen

    2018-01-01

    Full Text Available This paper investigates the characteristics of surface waves propagating on a grounded anisotropic dielectric slab. Distinct from the existing analyses that generally assume that the fields of surface wave uniformly distribute along the transverse direction of the infinitely large grounded slab, our method takes into account the field variations along the transverse direction of a finite-width slab. By solving Maxwell’s equations in closed-form, it is revealed that no pure transverse magnetic (TM or transverse electric (TE mode exists if the fields are non-uniformly distributed along the transverse direction of the grounded slab. Instead, two hybrid modes, namely quasi-TM and quasi-TE modes, are supported. In addition, the propagation characteristics of two hybrid modes supported by the grounded anisotropic slab are analyzed in terms of the slab thickness, slab width, as well as the relative permittivity tensor of the anisotropic slab. Furthermore, different methods are employed to compare the analyses, as well as to validate our derivations. The proposed method is very suitable for practical engineering applications.

  6. A methodology for developing anisotropic AAA phantoms via additive manufacturing.

    Science.gov (United States)

    Ruiz de Galarreta, Sergio; Antón, Raúl; Cazón, Aitor; Finol, Ender A

    2017-05-24

    An Abdominal Aortic Aneurysm (AAA) is a permanent focal dilatation of the abdominal aorta at least 1.5 times its normal diameter. The criterion of maximum diameter is still used in clinical practice, although numerical studies have demonstrated the importance of biomechanical factors for rupture risk assessment. AAA phantoms could be used for experimental validation of the numerical studies and for pre-intervention testing of endovascular grafts. We have applied multi-material 3D printing technology to manufacture idealized AAA phantoms with anisotropic mechanical behavior. Different composites were fabricated and the phantom specimens were characterized by biaxial tensile tests while using a constitutive model to fit the experimental data. One composite was chosen to manufacture the phantom based on having the same mechanical properties as those reported in the literature for human AAA tissue; the strain energy and anisotropic index were compared to make this choice. The materials for the matrix and fibers of the selected composite are, respectively, the digital materials FLX9940 and FLX9960 developed by Stratasys. The fiber proportion for the composite is equal to 0.15. The differences between the composite behavior and the AAA tissue are small, with a small difference in the strain energy (0.4%) and a maximum difference of 12.4% in the peak Green strain ratio. This work represents a step forward in the application of 3D printing technology for the manufacturing of AAA phantoms with anisotropic mechanical behavior. Copyright © 2017 Elsevier Ltd. All rights reserved.

  7. Effective Elliptic Models for Efficient Wavefield Extrapolation in Anisotropic Media

    KAUST Repository

    Waheed, Umair bin

    2014-05-01

    Wavefield extrapolation operator for elliptically anisotropic media offers significant cost reduction compared to that of transversely isotropic media (TI), especially when the medium exhibits tilt in the symmetry axis (TTI). However, elliptical anisotropy does not provide accurate focusing for TI media. Therefore, we develop effective elliptically anisotropic models that correctly capture the kinematic behavior of the TTI wavefield. Specifically, we use an iterative elliptically anisotropic eikonal solver that provides the accurate traveltimes for a TI model. The resultant coefficients of the elliptical eikonal provide the effective models. These effective models allow us to use the cheaper wavefield extrapolation operator for elliptic media to obtain approximate wavefield solutions for TTI media. Despite the fact that the effective elliptic models are obtained by kinematic matching using high-frequency asymptotic, the resulting wavefield contains most of the critical wavefield components, including the frequency dependency and caustics, if present, with reasonable accuracy. The methodology developed here offers a much better cost versus accuracy tradeoff for wavefield computations in TTI media, considering the cost prohibitive nature of the problem. We demonstrate the applicability of the proposed approach on the BP TTI model.

  8. Computational Study of Subdural Cortical Stimulation: Effects of Simulating Anisotropic Conductivity on Activation of Cortical Neurons.

    Directory of Open Access Journals (Sweden)

    Hyeon Seo

    Full Text Available Subdural cortical stimulation (SuCS is an appealing method in the treatment of neurological disorders, and computational modeling studies of SuCS have been applied to determine the optimal design for electrotherapy. To achieve a better understanding of computational modeling on the stimulation effects of SuCS, the influence of anisotropic white matter conductivity on the activation of cortical neurons was investigated in a realistic head model. In this paper, we constructed pyramidal neuronal models (layers 3 and 5 that showed primary excitation of the corticospinal tract, and an anatomically realistic head model reflecting complex brain geometry. The anisotropic information was acquired from diffusion tensor magnetic resonance imaging (DT-MRI and then applied to the white matter at various ratios of anisotropic conductivity. First, we compared the isotropic and anisotropic models; compared to the isotropic model, the anisotropic model showed that neurons were activated in the deeper bank during cathodal stimulation and in the wider crown during anodal stimulation. Second, several popular anisotropic principles were adapted to investigate the effects of variations in anisotropic information. We observed that excitation thresholds varied with anisotropic principles, especially with anodal stimulation. Overall, incorporating anisotropic conductivity into the anatomically realistic head model is critical for accurate estimation of neuronal responses; however, caution should be used in the selection of anisotropic information.

  9. Oxidative Stress-Responsive Apoptosis Inducing Protein (ORAIP) Plays a Critical Role in High Glucose-Induced Apoptosis in Rat Cardiac Myocytes and Murine Pancreatic β-Cells.

    Science.gov (United States)

    Yao, Takako; Fujimura, Tsutomu; Murayama, Kimie; Okumura, Ko; Seko, Yoshinori

    2017-10-18

    We previously identified a novel apoptosis-inducing humoral factor in the conditioned medium of hypoxic/reoxygenated-cardiac myocytes. We named this novel post-translationally-modified secreted-form of eukaryotic translation initiation factor 5A Oxidative stress-Responsive Apoptosis-Inducing Protein (ORAIP). We confirmed that myocardial ischemia/reperfusion markedly increased plasma ORAIP levels and rat myocardial ischemia/reperfusion injury was clearly suppressed by neutralizing anti-ORAIP monoclonal antibodies (mAbs) in vivo. In this study, to investigate the mechanism of cell injury of cardiac myocytes and pancreatic β-cells involved in diabetes mellitus (DM), we analyzed plasma ORAIP levels in DM model rats and the role of ORAIP in high glucose-induced apoptosis of cardiac myocytes in vitro. We also examined whether recombinant-ORAIP induces apoptosis in pancreatic β-cells. Plasma ORAIP levels in DM rats during diabetic phase were about 18 times elevated as compared with non-diabetic phase. High glucose induced massive apoptosis in cardiac myocytes (66.2 ± 2.2%), which was 78% suppressed by neutralizing anti-ORAIP mAb in vitro. Furthermore, recombinant-ORAIP clearly induced apoptosis in pancreatic β-cells in vitro. These findings strongly suggested that ORAIP plays a pivotal role in hyperglycemia-induced myocardial injury and pancreatic β-cell injury in DM. ORAIP will be a biomarker and a critical therapeutic target for cardiac injury and progression of DM itself.

  10. Splittings, coalescence, bunch and snake patterns in the 3D nonlinear Schrödinger equation with anisotropic dispersion

    DEFF Research Database (Denmark)

    Germaschewski, K.; Grauer, R.; Bergé, L.

    2001-01-01

    are detailed and compared with those characterizing collapsing objects with no anisotropic dispersion. Their ability to mutually coalesce is also analyzed and modeled from the interaction of Gaussian components. Next, bunch-type and snake-type instabilities, which result from periodic modulations driven...... by even and odd localized modes, are studied. The influence of the initial wave amplitude, the amplitude and wavenumber of the perturbations on the interplay of snake and bunch patterns are finally discussed. (C) 2001 Elsevier Science B.V. All rights reserved....

  11. Anisotropic particles strengthen granular pillars under compression

    Science.gov (United States)

    Harrington, Matt; Durian, Douglas J.

    2018-01-01

    We probe the effects of particle shape on the global and local behavior of a two-dimensional granular pillar, acting as a proxy for a disordered solid, under uniaxial compression. This geometry allows for direct measurement of global material response, as well as tracking of all individual particle trajectories. In general, drawing connections between local structure and local dynamics can be challenging in amorphous materials due to lower precision of atomic positions, so this study aims to elucidate such connections. We vary local interactions by using three different particle shapes: discrete circular grains (monomers), pairs of grains bonded together (dimers), and groups of three bonded in a triangle (trimers). We find that dimers substantially strengthen the pillar and the degree of this effect is determined by orientational order in the initial condition. In addition, while the three particle shapes form void regions at distinct rates, we find that anisotropies in the local amorphous structure remain robust through the definition of a metric that quantifies packing anisotropy. Finally, we highlight connections between local deformation rates and local structure.

  12. Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents.

    Science.gov (United States)

    Hickman, M J; Samson, L D

    1999-09-14

    All cells are unavoidably exposed to chemicals that can alkylate DNA to form genotoxic damage. Among the various DNA lesions formed, O(6)-alkylguanine lesions can be highly cytotoxic, and we recently demonstrated that O(6)-methylguanine (O(6)MeG) and O(6)-chloroethylguanine (O(6)CEG) specifically initiate apoptosis in hamster cells. Here we show, in both hamster and human cells, that the MutSalpha branch of the DNA mismatch repair pathway (but not the MutSbeta branch) is absolutely required for signaling the initiation of apoptosis in response to O(6)MeGs and is partially required for signaling apoptosis in response to O(6)CEGs. Further, O(6)MeG lesions signal the stabilization of the p53 tumor suppressor, and such signaling is also MutSalpha-dependent. Despite this, MutSalpha-dependent apoptosis can be executed in a p53-independent manner. DNA mismatch repair status did not influence the response of cells to other inducers of p53 and apoptosis. Thus, it appears that mismatch repair status, rather than p53 status, is a strong indicator of the susceptibility of cells to alkylation-induced apoptosis. This experimental system will allow dissection of the signal transduction events that couple a specific type of DNA base lesion with the final outcome of apoptotic cell death.

  13. Activation of caspase-9 is required for UV-induced apoptosis of human keratinocytes.

    Science.gov (United States)

    Sitailo, Leonid A; Tibudan, Shalini S; Denning, Mitchell F

    2002-05-31

    UV radiation from the sun activates both the membrane death receptor and the intrinsic or mitochondrial apoptotic signaling pathways in epidermal keratinocytes, triggering apoptosis and affording protection against skin cancer formation. We have investigated the involvement of caspase-9 in the UV death effector pathway in human keratinocytes, since this is the initiating caspase in the mitochondrial pathway required for UV-induced apoptosis in some, but not all, cell types. UV radiation triggered activation of caspase-3, caspase-9, and caspase-8 with similar kinetics, although the rank order of activation was caspase-3 > caspase-9 > caspase-8. Inhibition of caspase-9 with either the peptide inhibitor benzyloxycarbonyl-Leu-Glu(OCH(3))-His-Asp(OCH(3))-fluoromethyl ketone, or expression of a catalytically inactive caspase-9 by retroviral transduction, protected normal keratinocytes from UV-induced apoptosis. HaCaT keratinocytes harboring mutant p53 alleles were also protected from UV-induced apoptosis by the dominant negative caspase-9. The dominant negative caspase-9 blocked UV-induced activation of caspase-3, caspase-9, and caspase-8, and also protected cells from the loss of mitochondrial membrane potential. In contrast, the dominant negative caspase-9 did not protect from anti-Fas-induced apoptosis or caspase activation. These results identify caspase-9 as the critical upstream caspase initiating apoptosis by UV radiation in human keratinocytes, the relevant cell type for this important environmental carcinogen.

  14. Mechanisms of Neuronal Apoptosis In Vivo

    National Research Council Canada - National Science Library

    Martin, Lee J

    2004-01-01

    .... Neuronal cell death in the form of apoptosis or necrosis occurs after exposure to neurotoxins, chemical warfare agents, radiation, viruses, and after seizures, trauma, limb amputation, and hypoxic...

  15. Apoptosis in cancer: from pathogenesis to treatment

    Directory of Open Access Journals (Sweden)

    Wong Rebecca SY

    2011-09-01

    Full Text Available Abstract Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions. It is also one of the most studied topics among cell biologists. An understanding of the underlying mechanism of apoptosis is important as it plays a pivotal role in the pathogenesis of many diseases. In some, the problem is due to too much apoptosis, such as in the case of degenerative diseases while in others, too little apoptosis is the culprit. Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die. The mechanism of apoptosis is complex and involves many pathways. Defects can occur at any point along these pathways, leading to malignant transformation of the affected cells, tumour metastasis and resistance to anticancer drugs. Despite being the cause of problem, apoptosis plays an important role in the treatment of cancer as it is a popular target of many treatment strategies. The abundance of literature suggests that targeting apoptosis in cancer is feasible. However, many troubling questions arise with the use of new drugs or treatment strategies that are designed to enhance apoptosis and critical tests must be passed before they can be used safely in human subjects.

  16. Mitochondrial Dynamics: Functional Link with Apoptosis

    Directory of Open Access Journals (Sweden)

    Hidenori Otera

    2012-01-01

    Full Text Available Mitochondria participate in a variety of physiologic processes, such as ATP production, lipid metabolism, iron-sulfur cluster biogenesis, and calcium buffering. The morphology of mitochondria changes dynamically due to their frequent fusion and division in response to cellular conditions, and these dynamics are an important constituent of apoptosis. The discovery of large GTPase family proteins that regulate mitochondrial dynamics, together with novel insights into the role of mitochondrial fusion and fission in apoptosis, has provided important clues to understanding the molecular mechanisms of cellular apoptosis. In this paper, we briefly summarize current knowledge of the role of mitochondrial dynamics in apoptosis and cell pathophysiology in mammalian cells.

  17. Mitochondrial dynamics: functional link with apoptosis.

    Science.gov (United States)

    Otera, Hidenori; Mihara, Katsuyoshi

    2012-01-01

    Mitochondria participate in a variety of physiologic processes, such as ATP production, lipid metabolism, iron-sulfur cluster biogenesis, and calcium buffering. The morphology of mitochondria changes dynamically due to their frequent fusion and division in response to cellular conditions, and these dynamics are an important constituent of apoptosis. The discovery of large GTPase family proteins that regulate mitochondrial dynamics, together with novel insights into the role of mitochondrial fusion and fission in apoptosis, has provided important clues to understanding the molecular mechanisms of cellular apoptosis. In this paper, we briefly summarize current knowledge of the role of mitochondrial dynamics in apoptosis and cell pathophysiology in mammalian cells.

  18. Mycobacterium tuberculosis effectors interfering host apoptosis signaling.

    Science.gov (United States)

    Liu, Minqiang; Li, Wu; Xiang, Xiaohong; Xie, Jianping

    2015-07-01

    Tuberculosis remains a serious human public health concern. The coevolution between its pathogen Mycobacterium tuberculosis and human host complicated the way to prevent and cure TB. Apoptosis plays subtle role in this interaction. The pathogen endeavors to manipulate the apoptosis via diverse effectors targeting key signaling nodes. In this paper, we summarized the effectors pathogen used to subvert the apoptosis, such as LpqH, ESAT-6/CFP-10, LAMs. The interplay between different forms of cell deaths, such as apoptosis, autophagy, necrosis, is also discussed with a focus on the modes of action of effectors, and implications for better TB control.

  19. Apoptosis and Molecular Targeting Therapy in Cancer

    Science.gov (United States)

    Hassan, Mohamed; Watari, Hidemichi; AbuAlmaaty, Ali; Ohba, Yusuke; Sakuragi, Noriaki

    2014-01-01

    Apoptosis is the programmed cell death which maintains the healthy survival/death balance in metazoan cells. Defect in apoptosis can cause cancer or autoimmunity, while enhanced apoptosis may cause degenerative diseases. The apoptotic signals contribute into safeguarding the genomic integrity while defective apoptosis may promote carcinogenesis. The apoptotic signals are complicated and they are regulated at several levels. The signals of carcinogenesis modulate the central control points of the apoptotic pathways, including inhibitor of apoptosis (IAP) proteins and FLICE-inhibitory protein (c-FLIP). The tumor cells may use some of several molecular mechanisms to suppress apoptosis and acquire resistance to apoptotic agents, for example, by the expression of antiapoptotic proteins such as Bcl-2 or by the downregulation or mutation of proapoptotic proteins such as BAX. In this review, we provide the main regulatory molecules that govern the main basic mechanisms, extrinsic and intrinsic, of apoptosis in normal cells. We discuss how carcinogenesis could be developed via defective apoptotic pathways or their convergence. We listed some molecules which could be targeted to stimulate apoptosis in different cancers. Together, we briefly discuss the development of some promising cancer treatment strategies which target apoptotic inhibitors including Bcl-2 family proteins, IAPs, and c-FLIP for apoptosis induction. PMID:25013758

  20. TOPICAL REVIEW Textured silicon nitride: processing and anisotropic properties

    Directory of Open Access Journals (Sweden)

    Xinwen Zhu and Yoshio Sakka

    2008-01-01

    Full Text Available Textured silicon nitride (Si3N4 has been intensively studied over the past 15 years because of its use for achieving its superthermal and mechanical properties. In this review we present the fundamental aspects of the processing and anisotropic properties of textured Si3N4, with emphasis on the anisotropic and abnormal grain growth of β-Si3N4, texture structure and texture analysis, processing methods and anisotropic properties. On the basis of the texturing mechanisms, the processing methods described in this article have been classified into two types: hot-working (HW and templated grain growth (TGG. The HW method includes the hot-pressing, hot-forging and sinter-forging techniques, and the TGG method includes the cold-pressing, extrusion, tape-casting and strong magnetic field alignment techniques for β-Si3N4 seed crystals. Each processing technique is thoroughly discussed in terms of theoretical models and experimental data, including the texturing mechanisms and the factors affecting texture development. Also, methods of synthesizing the rodlike β-Si3N4 single crystals are presented. Various anisotropic properties of textured Si3 N4 and their origins are thoroughly described and discussed, such as hardness, elastic modulus, bending strength, fracture toughness, fracture energy, creep behavior, tribological and wear behavior, erosion behavior, contact damage behavior and thermal conductivity. Models are analyzed to determine the thermal anisotropy by considering the intrinsic thermal anisotropy, degree of orientation and various microstructure factors. Textured porous Si3N4 with a unique microstructure composed of oriented elongated β-Si3N4 and anisotropic pores is also described for the first time, with emphasis on its unique mechanical and thermal-mechanical properties. Moreover, as an important related material, textured α-Sialon is also reviewed, because the presence of elongated α-Sialon grains allows the production of textured

  1. Modulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis by Helicobacter pylori in immune pathogenesis of gastric mucosal damage.

    Science.gov (United States)

    Tsai, Hwei-Fang; Hsu, Ping-Ning

    2017-02-01

    Helicobacter pylori infection is associated with chronic gastritis, peptic ulcer, gastric carcinoma, and gastric mucosa-associated lymphoid tissue lymphomas. Apoptosis induced by microbial infections is implicated in the pathogenesis of H. pylori infection. Enhanced gastric epithelial cell apoptosis during H. pylori infection was suggested to play an important role in the pathogenesis of chronic gastritis and gastric pathology. In addition to directly triggering apoptosis, H. pylori induces sensitivity to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in gastric epithelial cells. Human gastric epithelial cells sensitized to H. pylori confer susceptibility to TRAIL-mediated apoptosis via modulation of death-receptor signaling. The induction of TRAIL sensitivity by H. pylori is dependent upon the activation of caspase-8 and its downstream pathway. H. pylori induces caspase-8 activation via enhanced assembly of the TRAIL death-inducing signaling complex through downregulation of cellular FLICE-inhibitory protein. Moreover, H. pylori infection induces infiltration of T lymphocytes and triggers inflammation to augment apoptosis. In H. pylori infection, significant increases in CCR6 + CD3 + T cell infiltration in the gastric mucosa was observed, and the CCR6 ligand, CCL20 chemokine, was selectively expressed in inflamed gastric tissues. These mechanisms initiate chemokine-mediated T lymphocyte trafficking into inflamed epithelium and induce mucosal injury during Helicobacter infection. This article will review recent findings on the interactions of H. pylori with host-epithelial signaling pathways and events involved in the initiation of gastric pathology, including gastric inflammation and mucosal damage. Copyright © 2016. Published by Elsevier B.V.

  2. Development of Pore Pressure in Cohesionless Soils with Initial Shear Stresses during Cyclic Loading

    DEFF Research Database (Denmark)

    Ibsen, Lars Bo; Jacobsen, H. Moust

    1989-01-01

    A number of triaxial tests with the loading harmonically oscillating around an initial and anisotropic stress state have been performed. Hereby the influence of the initial shear stress on the development of pore pressure in a cohesionless  sand specimen have been clarified. A simple theory...

  3. Apoptosis-like yeast cell death in response to DNA damage and replication defects

    International Nuclear Information System (INIS)

    Burhans, William C.; Weinberger, Martin; Marchetti, Maria A.; Ramachandran, Lakshmi; D'Urso, Gennaro; Huberman, Joel A.

    2003-01-01

    In budding (Saccharomyces cerevisiae) and fission (Schizosaccharomyces pombe) yeast and other unicellular organisms, DNA damage and other stimuli can induce cell death resembling apoptosis in metazoans, including the activation of a recently discovered caspase-like molecule in budding yeast. Induction of apoptotic-like cell death in yeasts requires homologues of cell cycle checkpoint proteins that are often required for apoptosis in metazoan cells. Here, we summarize these findings and our unpublished results which show that an important component of metazoan apoptosis recently detected in budding yeast - reactive oxygen species (ROS) - can also be detected in fission yeast undergoing an apoptotic-like cell death. ROS were detected in fission and budding yeast cells bearing conditional mutations in genes encoding DNA replication initiation proteins and in fission yeast cells with mutations that deregulate cyclin-dependent kinases (CDKs). These mutations may cause DNA damage by permitting entry of cells into S phase with a reduced number of replication forks and/or passage through mitosis with incompletely replicated chromosomes. This may be relevant to the frequent requirement for elevated CDK activity in mammalian apoptosis, and to the recent discovery that the initiation protein Cdc6 is destroyed during apoptosis in mammals and in budding yeast cells exposed to lethal levels of DNA damage. Our data indicate that connections between apoptosis-like cell death and DNA replication or CDK activity are complex. Some apoptosis-like pathways require checkpoint proteins, others are inhibited by them, and others are independent of them. This complexity resembles that of apoptotic pathways in mammalian cells, which are frequently deregulated in cancer. The greater genetic tractability of yeasts should help to delineate these complex pathways and their relationships to cancer and to the effects of apoptosis-inducing drugs that inhibit DNA replication

  4. Manufacturing Initiative

    Data.gov (United States)

    National Aeronautics and Space Administration — The Advanced Manufacturing Technologies (AMT) Project supports multiple activities within the Administration's National Manufacturing Initiative. A key component of...

  5. Shear viscosity of QGP and the anisotropic flows within an event by event transport approach

    Directory of Open Access Journals (Sweden)

    Plumari S.

    2016-01-01

    Full Text Available We have employed a relativistic kinetic transport approach that incorporates initial state fluctuations to study the effect of a temperature dependent shear viscosity to entropy density ratio η/s(T on the build-up of the anisotropic flows υn(pT. We find that at LHC energies and for ultra-central collisions (0 – 0.2% the υn(pT have a stronger sensitivity to the T dependence of η/s in the QGP phase and this sensitivity increases with the order of the harmonic n. Moreover we have studied the correlation between the initial spatial anisotropies ϵn and the final flow coefficients 〈υn〉 for different centralities and for the two beam energies. The study shows that at LHC energies there is more correlation than at RHIC energies. In particular at LHC energies and for ultra-central collisions the linear correlation coefficient C(ϵn, υn ≈ 1 for n = 2, 3, 4 and 5 suggesting that the 〈υn〉 are strongly related to the initial value of ϵn.

  6. Analytical Method and Semianalytical Method for Analysis of Scattering by Anisotropic Sphere: A Review

    Directory of Open Access Journals (Sweden)

    Chao Wan

    2012-01-01

    Full Text Available The history of methods for the electromagnetic scattering by an anisotropic sphere has been reviewed. Two main methods, angular expansion method and T-matrix method, which are widely used for the anisotropic sphere, are expressed in Cartesian coordinate firstly. The comparison of those and the further exploration on the scattering field are illustrated afterwards. Based on the most general form concluded by variable separation method, the coupled electric field and magnetic field of radial anisotropic sphere can be derived. By simplifying the condition, simpler case of uniaxial anisotropic media is expressed with confirmed coefficients for the internal and external field. Details of significant phenomenon are presented.

  7. Materials Research Society Symposium Proceedings Volume 635. Anisotropic Nanoparticles - Synthesis, Characterization and Applications

    National Research Council Canada - National Science Library

    Lyon, L

    2000-01-01

    This volume contains a series of papers originally presented at Symposium C, "Anisotropic Nanoparticles Synthesis, Characterization and Applications," at the 2000 MRS Fall Meeting in Boston, Massachusetts...

  8. Host-pathogen interactions during apoptosis

    Indian Academy of Sciences (India)

    Unknown

    rity and tissue homeostasis in multicellular organisms. (Vaux and Strasser 1996). Apoptosis characteristically occurs in isolated single cells. Inappropriate apoptosis is linked to a number of parasitic infections as well as the cause and progression of diseases such as neurodegenera- tive disorders, aging and cancer.

  9. Crosstalk between apoptosis and inflammation in atherosclerosis

    NARCIS (Netherlands)

    Westra, Marijke Marianne

    2010-01-01

    In this thesis the role of several apoptosis regulating proteins in the development of atherosclerosis and atherosclerotic plaque stability is investigated. Apoptosis of different cell types in atherosclerotic plaques, such as macrophages and smooth muscle cells may inhibit or promote plaque

  10. Apoptosis in mammalian oocytes: a review.

    Science.gov (United States)

    Tiwari, Meenakshi; Prasad, Shilpa; Tripathi, Anima; Pandey, Ashutosh N; Ali, Irfan; Singh, Arvind K; Shrivastav, Tulsidas G; Chaube, Shail K

    2015-08-01

    Apoptosis causes elimination of more than 99% of germ cells from cohort of ovary through follicular atresia. Less than 1% of germ cells, which are culminated in oocytes further undergo apoptosis during last phases of oogenesis and depletes ovarian reserve in most of the mammalian species including human. There are several players that induce apoptosis directly or indirectly in oocytes at various stages of meiotic cell cycle. Premature removal of encircling granulosa cells from immature oocytes, reduced levels of adenosine 3',5'-cyclic monophosphate and guanosine 3',5'-cyclic monophosphate, increased levels of calcium (Ca(2+)) and oxidants, sustained reduced level of maturation promoting factor, depletion of survival factors, nutrients and cell cycle proteins, reduced meiotic competency, increased levels of proapoptotic as well as apoptotic factors lead to oocyte apoptosis. The BH3-only proteins also act as key regulators of apoptosis in oocyte within the ovary. Both intrinsic (mitochondria-mediated) as well as extrinsic (cell surface death receptor-mediated) pathways are involved in oocyte apoptosis. BID, a BH3-only protein act as a bridge between both apoptotic pathways and its cleavage activates cell death machinery of both the pathways inside the follicular microenvironment. Oocyte apoptosis leads to the depletion of ovarian reserve that directly affects reproductive outcome of various mammals including human. In this review article, we highlight some of the important players and describe the pathways involved during oocyte apoptosis in mammals.

  11. Fas-induced apoptosis in malnourished infants

    African Journals Online (AJOL)

    EL-HAKIM

    deprivation in animals, including man11. Factor of apoptosis signal (Fas) induces apoptosis in activated T cells when they are repeatedly stimulated by antigen and functions to maintain T cell tolerance by deleting auto reactive cells12. The functional role of Fas (CD95) in the immune system has been examined in a variety ...

  12. An anisotropic, elastic-decohesive constitutive relation for modeling Arctic sea ice

    Science.gov (United States)

    Sulsky, D.; Tran, H.; Schreyer, H.

    2016-12-01

    As high-resolution simulations become increasingly possible and popular, questions are being raised about isotropic constitutive models for sea ice that are based on averaging material behavior over 100 km scales. At finer resolutions, it may not be appropriate to average over concentrated deformations which occur in leads and ridges since small regions do not contain sufficient numbers of these features at arbitrary orientations to support the assumption of isotropy. An elastic-decohesive constitutive model for pack ice has been developed that explicitly accounts for leads. The constitutive model is based on elasticity combined with a cohesive crack law that predicts the initiation, orientation and opening of leads. This talk presents extensions of the original model that tie it more closely to the thermodynamics and thickness distribution. Before failure, sea ice itself is assumed to be described by isotropic elasticity. However, an element of ice composed of different thicknesses, including refrozen leads and/or ridges, is modeled as an equivalent anisotropic elastic material of uniform thickness. The classical rule-of-mixtures is applied for the ice `composite' having an oriented distribution of thickness to derive the moduli and the strengths of the equivalent material. At failure, a decohesive constitutive relation based on the traction on a potential crack plane is employed in the anisotropic material. Sample paths in stress and strain space are examined to illustrate the aspects of the model when simulating the failure of sea ice. Simulations with the improved model show how failure is influenced by the oriented thickness distribution, for example, by failure occurring preferentially in thin ice.

  13. Paramagnetic Meissner effect of high-temperature granular superconductors: Interpretation by anisotropic and isotropic models

    International Nuclear Information System (INIS)

    Chen, F.H.; Horng, W.C.; Hsu, H.T.; Tseng, T.Y.

    1995-01-01

    The field-cooled magnetization of high-T c superconducting ceramics measured in low magnetic field exhibits the paramagnetic Meissner effect (PME), i.e., the diamagnetic signal initially increases with decrease in temperature but reaches a maximum at temperature T d and later decreases with decrease in temperature. Even in some samples the signal is ultimately able to transform inversely into a paramagnetic regime once the sample is cooled below a temperature T p as long as the applied field is sufficiently small. This PME has been observed in various high-T c cuprates and is explained by disparate aspects. An anisotropic model, in which the granular superconductors are assumed to be ideally anisotropic, was first alternatively proposed in the present work so as to theoretically account for this effect. On the other hand, an isotropic model, suitable for granular superconductors with randomly oriented grains, was proposed to deal with the samples prepared by a conventional solid-state reaction method. The anomalous magnetization behavior in the present model was demonstrated to be the superposition of the diamagnetic signal, which occurs as a result of the intragranular shielding currents, over the paramagnetic one due to the induction of the intergranular component induced by these currents where the intergranular one behaved as the effective pinning centers. The PME was demonstrated by this model to exist parasitically in granular superconductors. This intergranular effect is therefore worthy of remark when evaluating the volume fraction of superconductivity for the samples from the Meissner signal, in particular, at a low magnetic field

  14. Cancer Therapy Due to Apoptosis: Galectin-9

    Directory of Open Access Journals (Sweden)

    Koji Fujita

    2017-01-01

    Full Text Available Dysregulation of apoptosis is a major hallmark in cancer biology that might equip tumors with a higher malignant potential and chemoresistance. The anti-cancer activities of lectin, defined as a carbohydrate-binding protein that is not an enzyme or antibody, have been investigated for over a century. Recently, galectin-9, which has two distinct carbohydrate recognition domains connected by a linker peptide, was noted to induce apoptosis in thymocytes and immune cells. The apoptosis of these cells contributes to the development and regulation of acquired immunity. Furthermore, human recombinant galectin-9, hG9NC (null, which lacks an entire region of the linker peptide, was designed to resist proteolysis. The hG9NC (null has demonstrated anti-cancer activities, including inducing apoptosis in hematological, dermatological and gastrointestinal malignancies. In this review, the molecular characteristics, history and apoptosis-inducing potential of galectin-9 are described.

  15. Apoptosis in inner ear sensory hair cells

    Directory of Open Access Journals (Sweden)

    Seth Morrill

    2017-12-01

    Full Text Available Apoptosis, or controlled cell death, is a normal part of cellular lifespan. Cell death of cochlear hair cells causes deafness; an apoptotic process that is not well understood. Worldwide, 1.3 billion humans suffer some form of hearing loss, while 360 million suffer debilitating hearing loss as a direct result of the absence of these cochlear hair cells (Worldwide Hearing, 2014. Much is known about apoptosis in other systems and in other cell types thanks to studies done since the mid-20th century. Here we review current literature on apoptosis in general, and causes of deafness and cochlear hair cells loss as a result of apoptosis. The family of B-cell lymphoma (Bcl proteins are among the most studied and characterized. We will review current literature on the Bcl2 and Bcl6 protein interactions in relation to apoptosis and their possible roles in vulnerability and survival of cochlear hair cells.

  16. Multimesh anisotropic adaptivity for the Boltzmann transport equation

    International Nuclear Information System (INIS)

    Baker, C.M.J.; Buchan, A.G.; Pain, C.C.; Farrell, P.E.; Eaton, M.D.; Warner, P.

    2013-01-01

    Highlights: ► We solve the Boltzmann transport equation using anisotropically adaptive finite element meshes. ► The finite element mesh is resolved with minimal user input. ► Anisotropic adaptivity uses less elements than adaptive mesh refinement for the same finite element error. ► This paper also demonstrates the use of separate meshes for each energy group within the multigroup discretisation. ► The methods are applied to a range of fixed source and eigenvalue problems. - Abstract: This article presents a new adaptive finite element based method for the solution of the spatial dimensions of the Boltzmann transport equation. The method applies a curvature based error metric to locate the under and over resolved regions of a solution and this, in turn, is used to guide the refinement and coarsening of the spatial mesh. The error metrics and re-meshing procedures are designed such that they enable anisotropic resolution to form in the mesh should it be appropriate to do so. The adaptive mesh enables the appropriate resolution to be applied throughout the whole domain of a problem and so increase the efficiency of the solution procedure. Another new approach is also described that allows independent adaptive meshes to form for each of the energy group fluxes. The use of independent meshes can significantly improve computational efficiency when solving problems where the different group fluxes require high resolution over different regions. The mesh to mesh interpolation is made possible through the use of a ‘supermeshing’ procedure that ensures the conservation of particles when calculating the group to group scattering sources. Finally it is shown how these methods can be incorporated within a solver to resolve both fixed source and eigenvalue problems. A selection of both fixed source and eigenvalue problems are solved in order to demonstrate the capabilities of these methods

  17. Quarkonium states in an anisotropic quark-gluon plasma

    Energy Technology Data Exchange (ETDEWEB)

    Guo Yun

    2009-09-10

    In this work we study the properties of quarkonium states in a quark-gluon plasma which, due to expansion and non-zero viscosity, exhibits a local anisotropy in momentum space. We determine the hard-loop resummed gluon propagator in an anisotropic QCD plasma in general linear gauges and define a potential between heavy quarks from the Fourier transform of its static limit. This potential which arises due to one-gluon exchange describes the force between a quark and anti-quark at short distances. It is closer to the vacuum potential as compared to the isotropic Debye screened potential which indicates the reduced screening in an anisotropic QCD plasma. In addition, angular dependence appears in the potential; we find that there is stronger attraction on distance scales on the order of the inverse Debye mass for quark pairs aligned along the direction of anisotropy than for transverse alignment. The potential at long distances, however, is non-perturbative and modeled as a QCD string which is screened at the same scale as the Coulomb field. At asymptotic separation the potential energy is non-zero and inversely proportional to the temperature. With a phenomenological potential model which incorporates the different behaviors at short and long distances, we solve the three-dimensional Schroedinger equation. Our numerical results show that quarkonium binding is stronger at non-vanishing viscosity and expansion rate, and that the anisotropy leads to polarization of the P-wave states. Furthermore, we determine viscosity corrections to the imaginary part of the heavy-quark potential in the weak-coupling hard-loop approximation. The imaginary part is found to be smaller (in magnitude) than at vanishing viscosity. This implies a smaller decay width of quarkonium bound states in an anisotropic plasma. (orig.)

  18. Anisotropic Alfven-ballooning modes in the Earth's magnetosphere

    International Nuclear Information System (INIS)

    Chan, A.A.; Xia, Mengfen; Chen, Liu

    1993-05-01

    We have carried out a theoretical analysis of the stability and parallel structure of coupled shear-Alfven and slow-magnetosonic waves in the Earth's inner magnetosphere including effects of finite anisotropic plasma pressure. Multiscale perturbation analysis of the anisotropic Grad-Shafranov equation yields an approximate self-consistent magnetohydrodynamic (MHD) equilibrium. This MHD equilibrium is used in the numerical solution of a set of eigenmode equations which describe the field line eigenfrequency, linear stability, and parallel eigenmode structure. We call these modes anisotropic Alfven-ballooning modes. The main results are: The field line eigenfrequency can be significantly lowered by finite pressure effects. The parallel mode structure of the transverse wave components is fairly insensitive to changes in the plasma pressure but the compressional magnetic component can become highly peaked near the magnetic equator due to increased pressure, especially when P perpendicular > P parallel. For the isotropic case ballooning instability can occur when the ratio of the plasma pressure to the magnetic pressure, exceeds a critical value β o B ∼ 3.5 at the equator. Compared to the isotropic case the critical beta value is lowered by anisotropy, either due to decreased field-line-bending stabilization when P parallel > P perpendicular, or due to increased ballooning-mirror destabilization when P perpendicular > P parallel. We use a ''β-6 stability diagram'' to display the regions of instability with respect to the equatorial values of the parameters bar β and δ, where bar β = (1/3)(β parallel + 2 β perpendicular) is an average beta value and δ = 1 - P parallel/P perpendicular is a measure of the plasma anisotropy

  19. Numerical investigation of nanoparticles transport in anisotropic porous media

    KAUST Repository

    Salama, Amgad

    2015-07-13

    In this work the problem related to the transport of nanoparticles in anisotropic porous media is investigated numerically using the multipoint flux approximation. Anisotropy of porous media properties are an essential feature that exist almost everywhere in subsurface formations. In anisotropic media, the flux and the pressure gradient vectors are no longer collinear and therefore interesting patterns emerge. The transport of nanoparticles in subsurface formations is affected by several complex processes including surface charges, heterogeneity of nanoparticles and soil grain collectors, interfacial dynamics of double-layer and many others. We use the framework of the theory of filtration in this investigation. Processes like particles deposition, entrapment, as well as detachment are accounted for. From the numerical methods point of view, traditional two-point flux finite difference approximation cannot handle anisotropy of media properties. Therefore, in this work we use the multipoint flux approximation (MPFA). In this technique, the flux components are affected by more neighboring points as opposed to the mere two points that are usually used in traditional finite volume methods. We also use the experimenting pressure field approach which automatically constructs the global system of equations by solving multitude of local problems. This approach facilitates to a large extent the construction of the global system. A set of numerical examples is considered involving two-dimensional rectangular domain. A source of nanoparticles is inserted in the middle of the anisotropic layer. We investigate the effects of both anisotropy angle and anisotropy ratio on the transport of nanoparticles in saturated porous media. It is found that the concentration plume and porosity contours follow closely the principal direction of anisotropy of permeability of the central domain.

  20. Quarkonium states in an anisotropic quark-gluon plasma

    International Nuclear Information System (INIS)

    Guo Yun

    2009-01-01

    In this work we study the properties of quarkonium states in a quark-gluon plasma which, due to expansion and non-zero viscosity, exhibits a local anisotropy in momentum space. We determine the hard-loop resummed gluon propagator in an anisotropic QCD plasma in general linear gauges and define a potential between heavy quarks from the Fourier transform of its static limit. This potential which arises due to one-gluon exchange describes the force between a quark and anti-quark at short distances. It is closer to the vacuum potential as compared to the isotropic Debye screened potential which indicates the reduced screening in an anisotropic QCD plasma. In addition, angular dependence appears in the potential; we find that there is stronger attraction on distance scales on the order of the inverse Debye mass for quark pairs aligned along the direction of anisotropy than for transverse alignment. The potential at long distances, however, is non-perturbative and modeled as a QCD string which is screened at the same scale as the Coulomb field. At asymptotic separation the potential energy is non-zero and inversely proportional to the temperature. With a phenomenological potential model which incorporates the different behaviors at short and long distances, we solve the three-dimensional Schroedinger equation. Our numerical results show that quarkonium binding is stronger at non-vanishing viscosity and expansion rate, and that the anisotropy leads to polarization of the P-wave states. Furthermore, we determine viscosity corrections to the imaginary part of the heavy-quark potential in the weak-coupling hard-loop approximation. The imaginary part is found to be smaller (in magnitude) than at vanishing viscosity. This implies a smaller decay width of quarkonium bound states in an anisotropic plasma. (orig.)

  1. Molecular Cell Biology of Apoptosis and Necroptosis in Cancer.

    Science.gov (United States)

    Dillon, Christopher P; Green, Douglas R

    Cell death is a major mechanism to eliminate cells in which DNA is damaged, organelles are stressed, or oncogenes are overexpressed, all events that would otherwise predispose cells to oncogenic transformation. The pathways that initiate and execute cell death are complex, genetically encoded, and subject to significant regulation. Consequently, while these pathways are often mutated in malignancy, there is considerable interest in inducing cell death in tumor cells as therapy. This chapter addresses our current understanding of molecular mechanisms contributing to two cell death pathways, apoptotic cell death and necroptosis, a regulated form of necrotic cell death. Apoptosis can be induced by a wide variety of signals, leading to protease activation that dismantles the cell. We discuss the physiological importance of each apoptosis pathway and summarize their known roles in cancer suppression and the current efforts at targeting each pathway therapeutically. The intricate mechanistic link between death receptor-mediated apoptosis and necroptosis is described, as well as the potential opportunities for utilizing necroptosis in the treatment of malignancy.

  2. HIV-1 subtype C unproductively infects human cardiomyocytes in vitro and induces apoptosis mitigated by an anti-Gp120 aptamer

    CSIR Research Space (South Africa)

    Rangel Lopes de Campos, W

    2014-10-01

    Full Text Available via the intrinsic or mitochondrial initiated pathway. CXCR4 receptor-using viruses were stronger inducers of apoptosis than CCR5 utilizing variants. Importantly, we discovered that HIV-1 induced apoptosis of cardiomyocytes was mitigated by UCLA1...

  3. Tunneling anisotropic magnetoresistance via molecular π orbitals of Pb dimers

    Science.gov (United States)

    Schöneberg, Johannes; Ferriani, Paolo; Heinze, Stefan; Weismann, Alexander; Berndt, Richard

    2018-01-01

    Pb dimers on a ferromagnetic surface are shown to exhibit large tunneling anisotropic magnetoresistance (TAMR) due to molecular π orbitals. Dimers oriented differently with respect to the magnetization directions of a ferromagnetic Fe double layer on W(110) were made with a scanning tunneling microscope. Depending on the dimer orientations, TAMR is absent or as large as 20% at the Fermi level. General arguments and first-principles calculations show that mixing of molecular orbitals due to spin-orbit coupling, which leads to TAMR, is maximal when the magnetization is oriented parallel to the dimer axis.

  4. Tunneling anisotropic magnetoresistance in single-molecule magnet junctions

    Science.gov (United States)

    Xie, Haiqing; Wang, Qiang; Jiao, Hujun; Liang, J.-Q.

    2012-08-01

    We theoretically investigate quantum transport through single-molecule magnet (SMM) junctions with ferromagnetic and normal-metal leads in the sequential regime. The current obtained by means of the rate-equation gives rise to the tunneling anisotropic magnetoresistance (TAMR), which varies with the angle between the magnetization direction of ferromagnetic lead and the easy axis of SMM. The angular dependence of TAMR can serve as a probe to determine experimentally the easy axis of SMM. Moreover, it is demonstrated that both the magnitude and the sign of TAMR are tunable by the bias voltage, suggesting a new spin-valve device with only one magnetic electrode in molecular spintronics.

  5. Outflow and clogging of shape-anisotropic grains in hoppers

    Science.gov (United States)

    Stannarius, Ralf; Ashour, Ahmed; Wegner, Sandra; BöRzsöNyi, Tamas

    Silos have been in use in human history for millennia, but still today, the discharge of grains from silos is a process with potential risks and imponderabilities. Models and quantitative predictions have been developed almost exclusively for spherical grains shapes. We study the discharge and clogging processes of shape-anisotropic grains in hoppers, and describe the peculiarities of these materials both in their dynamical properties and in the observed clogging structures. An attempt is made to adapt the well-known equations for spherical material to describe anisometric particles. Funding by DAAD and M\\x96B is acknowledged. A. A. acknowledges a scholarship from Future University, Egypt.

  6. Anisotropic superconducting state parameters of Tl-2212 superconductors

    International Nuclear Information System (INIS)

    Khaskalam, Amit K.; Singh, R.K.; Varshney, Dinesh

    2001-01-01

    We have estimated the superconducting state parameters and their anisotropy in thallium based superconductors (Tl-2212), in the frame work of Fermi liquid approach. Determination of the effective mass of the charge carriers from the Fermi velocity and estimated anisotropic superconducting state parameters, particularly, the magnetic penetration depth along and perpendicular to the conducting plane. The coherence length along and perpendicular to the ab plane is evaluated and appears to be higher. The temperature dependence of penetration depth, their anisotropy and Ginsburg Landau parameter for optimised doped Tl based cuprates shows the power law. The technique permits a consistency with the reported data. (author)

  7. Tungsten based anisotropic metamaterial as an ultra-broadband absorber

    DEFF Research Database (Denmark)

    Lin, Yinyue; Cui, Yanxia; Ding, Fei

    2017-01-01

    : We show theoretically that an array of tungsten/germanium anisotropic nano-cones placed on top of a reflective substrate can absorb light at the wavelength range from 0.3 μm to 9 μm with an average absorption efficiency approaching 98%. It is found that the excitation of multiple orders of slow...... of the nano-cones and the interaction between neighboring nano-cones is quite weak. Our proposal has some potential applications in the areas of solar energy harvesting and thermal emitters....

  8. Anisotropic magnetotelluric inversion using a mutual information constraint

    Science.gov (United States)

    Mandolesi, E.; Jones, A. G.

    2012-12-01

    In recent years, several authors pointed that the electrical conductivity of many subsurface structures cannot be described properly by a scalar field. With the development of field devices and techniques, data quality improved to the point that the anisotropy in conductivity of rocks (microscopic anisotropy) and tectonic structures (macroscopic anisotropy) cannot be neglected. Therefore a correct use of high quality data has to include electrical anisotropy and a correct interpretation of anisotropic data characterizes directly a non-negligible part of the subsurface. In this work we test an inversion routine that takes advantage of the classic Levenberg-Marquardt (LM) algorithm to invert magnetotelluric (MT) data generated from a bi-dimensional (2D) anisotropic domain. The LM method is routinely used in inverse problems due its performance and robustness. In non-linear inverse problems -such the MT problem- the LM method provides a spectacular compromise betwee quick and secure convergence at the price of the explicit computation and storage of the sensitivity matrix. Regularization in inverse MT problems has been used extensively, due to the necessity to constrain model space and to reduce the ill-posedness of the anisotropic MT problem, which makes MT inversions extremely challenging. In order to reduce non-uniqueness of the MT problem and to reach a model compatible with other different tomographic results from the same target region, we used a mutual information (MI) based constraint. MI is a basic quantity in information theory that can be used to define a metric between images, and it is routinely used in fields as computer vision, image registration and medical tomography, to cite some applications. We -thus- inverted for the model that best fits the anisotropic data and that is the closest -in a MI sense- to a tomographic model of the target area. The advantage of this technique is that the tomographic model of the studied region may be produced by any

  9. Chemical phase analysis of seed mediated synthesized anisotropic silver nanoparticles

    Energy Technology Data Exchange (ETDEWEB)

    Bharti, Amardeep, E-mail: abharti@pu.ac.in; Goyal, Navdeep [Department of Physics, Panjab University, Chandigarh, INDIA-160014 (India); Singh, Suman; Singla, M. L. [Agrionics, Central Scientific Instruments Organization, CSIR, Chandigarh, INDIA-160030 (India)

    2015-08-28

    Noble-metal nanoparticles are of great interest because of its broad applications almost in every stream (i.e. biology, chemistry and engineering) due to their unique size/shape dependant properties. In this paper, chemical phase of seed mediated synthesized anisotropic silver nanoparticle (AgNPs) has been investigated via fourier transform infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA). These nanaoparticles were synthesized by seed-growth method controlled by urea and dextrose results to highly stable 12-20 nm particle size revealed by zeta potential and transmission electron microscopy (TEM)

  10. Anisotropic structure beneath central Java from local earthquake tomography

    Science.gov (United States)

    Koulakov, Ivan; Jakovlev, Andrey; Luehr, Birger G.

    2009-02-01

    In this study we present the new tomographic code ANITA which provides 3-D anisotropic P and isotropic S velocity distribution based on P and S traveltimes from local seismicity. For the P anisotropic model, we determine four parameters for each parameterization cell. This represents an orthorhombic anisotropy with one predefined direction oriented vertically. Three of the parameters describe slowness variations along three horizontal orientations with azimuths of 0°, 60°, and 120°, and one is a perturbation along the vertical axis. The nonlinear iterative inversion procedure is similar to that used in the LOTOS code. We have implemented this algorithm for the updated data set of central Java, part of which was previously used for the isotropic inversion. It was obtained that the crustal and uppermost mantle velocity structure beneath central Java is strongly anisotropic with 7-10% of maximal difference between slow and fast velocity in different directions. In the forearc (area between southern coast and volcanoes), the structure of both isotropic and anisotropic structure is strongly heterogeneous. Variety of anisotropy orientations and highly contrasted velocity patterns can be explained by a complex block structure of the crust. Beneath volcanoes we observe faster velocities in vertical direction, which is probably an indicator for vertically oriented structures (channels, dykes). In the crust beneath the middle part of central Java, north to Merapi and Lawu volcanoes, we observe a large and very intense anomaly with a velocity decrease of up to 30% and 35% for P and S models, respectively. Inside this anomaly E-W orientation of fast velocity takes place, probably caused by regional extension stress regime. In a vertical section we observe faster horizontal velocities inside this anomaly that might be explained by layering of sediments and/or penetration of quasi-horizontal lenses with molten magma. In the mantle, trench parallel anisotropy is observed

  11. Nonaxisymmetric radiative transfer in inhomogeneous cylindrical media with anisotropic scattering

    International Nuclear Information System (INIS)

    Grissa, H.; Askri, F.; Ben Salah, M.; Ben Nasrallah, S.

    2008-01-01

    In this paper, the control volume finite element method (CVFEM) is applied for the first time to solve nonaxisymmetric radiative transfer in inhomogeneous, emitting, absorbing and anisotropic scattering cylindrical media. Mathematical formulations as well as numerical implementation are given and the final discretized equations are based on similar meshes used for convective and conductive heat transfer in computational fluid dynamic analysis. In order to test the efficiency of the developed method, four nonaxisymmetric problems have been examined. Also, the grid dependence and the false scattering of the CVFEM are investigated and compared with the finite volume method and the discrete ordinates interpolation method

  12. Anisotropic tunneling resistance in a phosphorene-based magnetic barrier

    Science.gov (United States)

    Zhai, Feng; Hu, Wei; Lu, Junqiang

    2017-10-01

    We investigate the ballistic tunneling transport properties of a monolayer of black phosphorus under a magnetic barrier. The conductance of the system depends strongly on the orientation of the magnetic barrier, which is suppressed maximally when the magnetic barrier is oriented along the armchair direction. The mechanism relies on the highly anisotropic energy dispersion of phosphorene and the magnetic-barrier-induced suppression of available phase space for transmission. The magnetoresistance is enhanced by the reduction of the band gap under the same effective mass components.

  13. Aeroelastic modal dynamics of wind turbines including anisotropic effects

    DEFF Research Database (Denmark)

    Skjoldan, Peter Fisker

    and the computationally efficient implicit Floquet analysis in anisotropic conditions. The tool is validated against system identifications with the partial Floquet method on the nonlinear BHawC model of a 2.3 MW wind turbine. System identification results show that nonlinear effects on the 2.3 MW turbine in most cases....... These harmonics appear in calculated frequency responses of the turbine. Extreme wind shear changes the modal damping when the flow is separated due to an interaction between the periodic mode shape and the local aerodynamic damping influenced by a periodic variation in angle of attack....

  14. Theoretical assessment of sound absorption coefficient for anisotropic nonwovens

    Directory of Open Access Journals (Sweden)

    Klara Kalinova

    2012-03-01

    Full Text Available The anisotropy factor as a function of fiber arrangement, fiber fineness and sample thickness has been derived from the theories of soundwave transformation due to phase changing. The sound absorption coefficient of the anisotropic fibrous material is then theoretically calculated. The fibrous materials were prepared so that the fibers are arranged parallel (perpendicularly laid fiber web called STRUTO technology in the direction of soundwave propagation or perpendicularly (longitudinally laid fiber web to the direction of sound propagation. The sound absorption coefficient was measured due to the Impedance tube. The theoretical results are in good agreement with experimental findings.

  15. Anisotropic Third-Order Regularization for Sparse Digital Elevation Models

    KAUST Repository

    Lellmann, Jan

    2013-01-01

    We consider the problem of interpolating a surface based on sparse data such as individual points or level lines. We derive interpolators satisfying a list of desirable properties with an emphasis on preserving the geometry and characteristic features of the contours while ensuring smoothness across level lines. We propose an anisotropic third-order model and an efficient method to adaptively estimate both the surface and the anisotropy. Our experiments show that the approach outperforms AMLE and higher-order total variation methods qualitatively and quantitatively on real-world digital elevation data. © 2013 Springer-Verlag.

  16. Gaussian beam diffraction in weakly anisotropic inhomogeneous media

    Energy Technology Data Exchange (ETDEWEB)

    Kravtsov, Yu.A., E-mail: kravtsov@am.szczecin.p [Institute of Physics, Maritime University of Szczecin, Szczecin 70-500 (Poland); Space Research Institute, Russian Academy of Science, Moscow 117 997 (Russian Federation); Berczynski, P., E-mail: pawel.berczynski@ps.p [Institute of Physics, West Pomeranian University of Technology, Szczecin 70-310 (Poland); Bieg, B., E-mail: b.bieg@am.szczecin.p [Institute of Physics, Maritime University of Szczecin, Szczecin 70-500 (Poland)

    2009-08-10

    Combination of quasi-isotropic approximation (QIA) of geometric optics with paraxial complex geometric optics (PCGO) is suggested, which allows describing both diffraction and polarization evolution of Gaussian electromagnetic beams in weakly anisotropic inhomogeneous media. Combination QIA/PCGO reduces Maxwell equations to the system of the ordinary differential equations of the first order and radically simplifies solution of various problems, related to microwave plasma diagnostics, including plasma polarimetry, interferometry and refractometry in thermonuclear reactors. Efficiency of the method is demonstrated by the example of electromagnetic beam diffraction in a linear layer of magnetized plasma with parameters, modeling tokamak plasma in the project ITER.

  17. Wormhole solution of BD theory in an anisotropic radiation background

    Directory of Open Access Journals (Sweden)

    B. Nasre Esfahani

    2001-06-01

    Full Text Available   Time-dependent wormhole solution of the BD theory in an anisotropic radiation background is presented. It is also found that the BD scalar field depends only on time. This time dependency is in power-law form. It is shown that the wormhole geometry is valid for ω ≥ -3/2, and for any arbitrary positive values of . The GR limit of our solution is obtained for ω=0 , not for ω→∞ . Though the BD field can be non-exotic, the background material is entirely exotic.

  18. Comparing energy levels in isotropic and anisotropic potentials

    International Nuclear Information System (INIS)

    Pikovski, Alexander

    2015-01-01

    Qualitative information about the quantized energy levels of a system can be of great value. We study the relationship between the bound-state energies of an anisotropic potential and those of its spherical average. It is shown that the two ground-state energies satisfy an inequality, and there is a similar inequality for the first excited states. - Highlights: • Quantized energy levels in an arbitrary non-central potential are studied. • We derive inequalities between energies in a potential and its spherical average. • The results hold in three and two dimensions for any ground state and, with additional symmetry requirements for the first excited state.

  19. Kelvin circulation in a cranked anisotropic oscillator + BCS mean field

    International Nuclear Information System (INIS)

    Rosensteel, G.; Goodman, A.L.; Tulane, U.

    1993-01-01

    The Kelvin circulation vector is the hermitian kinematical observable that measures the true character of nuclear rotation. For a rotating deformed nucleus modeled by a self-consistent cranked anisotropic oscillator mean field with BCS pairing, the expectation value of the Kelvin circulation operator depends upon the deformation and upon the strength of the pairing field. For zero pairing, the circulation acquires its rigid rotor value. As the pairing field increases, the circulation tends to zero, the irrotational flow limit. At critical values of the pairing field, the deformation and circulation make abrupt phase transitions

  20. An anisotropic three-fluid model for heavy ion reactions

    International Nuclear Information System (INIS)

    Lovas, I.; Zimanyi, J.; Csernai, L.P.; Greiner, W.

    1981-01-01

    The nucleons taking part in heavy ion reactions are considered as a three-fluid system. The first and second components correspond to the target and the projectile, while the thermalised nucleons produced in the course of the collision belong to the third component. Making use of the Boltzmann-equation, hydrodynamical equations are derived which yield also the anisotropy of the momentum distribution. The equation of state for anisotropic nuclear matter is derived from a field theoretical model in the mean field approximation. (Auth.)

  1. Anisotropic hydrodynamics, holography and the chiral magnetic effect

    International Nuclear Information System (INIS)

    Gahramanov, Ilmar; Kalaydzhyan, Tigran; Kirsch, Ingo; Hamburg Univ.

    2012-03-01

    We discuss a possible dependence of the chiral magnetic effect (CME) on the elliptic flow coefficient υ 2 . We first study this in a hydrodynamic model for a static anisotropic plasma with multiple anomalous U(1) currents. In the case of two charges, one axial and one vector, the CME formally appears as a first-order transport coefficient in the vector current. We compute this transport coefficient and show its dependence on υ 2 . We also determine the CME-coefficient from first-order corrections to the dual AdS background using the fluid-gravity duality. For small anisotropies, we find numerical agreement with the hydrodynamic result. (orig.)

  2. Electromagnetic fields due to dipole antennas over stratified anisotropic media.

    Science.gov (United States)

    Kong, J. A.

    1972-01-01

    Solutions to the problem of radiation of dipole antennas in the presence of a stratified anisotropic media are facilitated by decomposing a general wave field into transverse magnetic (TM) and transverse electric (TE) modes. Employing the propagation matrices, wave amplitudes in any region are related to those in any other regions. The reflection coefficients, which embed all the information about the geometrical configuration and the physical constituents of the medium, are obtained in closed form. In view of the general formulation, various special cases are discussed.

  3. Existence and uniqueness in anisotropic conductivity reconstruction with Faraday's law

    KAUST Repository

    Lee, Min-Gi

    2015-03-18

    We show that three sets of internal current densities are the right amount of data that give the existence and the uniqueness at the same time in reconstructing an anisotropic conductivity in two space dimensions. The curl free equation of Faraday’s law is taken instead of the usual divergence free equation of the electrical impedance to- mography. Boundary conditions related to given current densities are introduced which complete a well determined problem for conductivity reconstruction together with Fara- day’s law.

  4. Love wave dispersion in anisotropic visco-elastic medium

    Directory of Open Access Journals (Sweden)

    G. GIR SUBHASH

    1978-06-01

    Full Text Available The paper presents a study on Love wave propagation in a anisotropic
    visco-elastic layer overlying a rigid half space. The characteristic frequency
    equation is obtained and the variation of the wave number with frequency
    under the combined effect of visco-elasticity and anisotropy is analysed
    in detail. The results show that the effect of visco-elasticity on the
    wave is similar to that of anisotropy as long as the coefficient of anisotropy
    is less than unity.

  5. Anisotropic magnetoresistance components in (Ga,Mn)As

    Czech Academy of Sciences Publication Activity Database

    Rushforth, A.W.; Výborný, Karel; King, C.S.; Edmonds, K. W.; Campion, R. P.; Foxon, C. T.; Wunderlich, J.; Irvine, A.C.; Vašek, Petr; Novák, Vít; Olejník, Kamil; Sinova, J.; Jungwirth, Tomáš; Gallagher, B. L.

    2007-01-01

    Roč. 99, č. 14 (2007), 147207/1-147207/4 ISSN 0031-9007 R&D Projects: GA ČR GA202/05/0575; GA ČR GA202/04/1519; GA ČR GEFON/06/E002; GA MŠk LC510 Grant - others:UK(GB) GR/S81407/01 Institutional research plan: CEZ:AV0Z10100521 Keywords : ferromagnetic semiconductors * anisotropic magnetoresistence Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 6.944, year: 2007

  6. Highly Sensitive Flexible Magnetic Sensor Based on Anisotropic Magnetoresistance Effect.

    Science.gov (United States)

    Wang, Zhiguang; Wang, Xinjun; Li, Menghui; Gao, Yuan; Hu, Zhongqiang; Nan, Tianxiang; Liang, Xianfeng; Chen, Huaihao; Yang, Jia; Cash, Syd; Sun, Nian-Xiang

    2016-11-01

    A highly sensitive flexible magnetic sensor based on the anisotropic magnetoresistance effect is fabricated. A limit of detection of 150 nT is observed and excellent deformation stability is achieved after wrapping of the flexible sensor, with bending radii down to 5 mm. The flexible AMR sensor is used to read a magnetic pattern with a thickness of 10 μm that is formed by ferrite magnetic inks. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  7. Huge tunnelling anisotropic magnetoresistance in (Ga,Mn)As nanoconstrictions

    Czech Academy of Sciences Publication Activity Database

    Giddings, A.D.; Makarovsky, O. N.; Khalid, M.N.; Yasin, S.; Edmonds, K. W.; Campion, R. P.; Wunderlich, J.; Jungwirth, Tomáš; Williams, D.A.; Gallagher, B. L.; Foxon, C. T.

    2008-01-01

    Roč. 10, č. 8 (2008), 085004/1-085004/9 ISSN 1367-2630 R&D Projects: GA ČR GEFON/06/E002; GA MŠk LC510; GA ČR GA202/05/0575; GA ČR GA202/04/1519 EU Projects: European Commission(XE) 015728 - NANOSPIN Institutional research plan: CEZ:AV0Z10100521 Keywords : ferromagnetic semiconductor * nanoconstriction * tunneling anisotropic magnetoresistance , Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 3.440, year: 2008

  8. Anisotropic cell growth-regulated surface micropatterns in flower petals

    Directory of Open Access Journals (Sweden)

    Xiao Huang

    2017-05-01

    Full Text Available Flower petals have not only diverse macroscopic morphologies but are rich in microscopic surface patterns, which are crucial to their biological functions. Both experimental measurements and theoretical analysis are conducted to reveal the physical mechanisms underlying the formation of minute wrinkles on flower petals. Three representative flowers, daisy, kalanchoe blossfeldiana, and Eustoma grandiflorum, are investigated as examples. A surface wrinkling model, incorporating the measured mechanical properties and growth ratio, is used to elucidate the difference in their surface morphologies. The mismatch between the anisotropic epidermal cell growth and the isotropic secretion of surficial wax is found to dictate the surface patterns.

  9. Scheme for achieving coherent perfect absorption by anisotropic metamaterials

    KAUST Repository

    Zhang, Xiujuan

    2017-02-22

    We propose a unified scheme to achieve coherent perfect absorption of electromagnetic waves by anisotropic metamaterials. The scheme describes the condition on perfect absorption and offers an inverse design route based on effective medium theory in conjunction with retrieval method to determine practical metamaterial absorbers. The scheme is scalable to frequencies and applicable to various incident angles. Numerical simulations show that perfect absorption is achieved in the designed absorbers over a wide range of incident angles, verifying the scheme. By integrating these absorbers, we further propose an absorber to absorb energy from two coherent point sources.

  10. Strain effects on anisotropic magnetoresistance in a nanowire spin valve

    Science.gov (United States)

    Hossain, Md I.; Maksud, M.; Subramanian, A.; Atulasimha, J.; Bandyopadhyay, S.

    2016-11-01

    The longitudinal magnetoresistance of a copper nanowire contacted by two cobalt contacts shows broad spin-valve peaks at room temperature. However, when the contacts are slightly heated, the peaks change into troughs which are signature of anisotropic magnetoresistance (AMR). Under heating, the differential thermal expansion of the contacts and the substrate generates a small strain in the cobalt contacts which enhances the AMR effect sufficiently to change the peak into a trough. This shows the extreme sensitivity of AMR to strain. The change in the AMR resistivity coefficient due to strain is estimated to be a few m Ω -m/microstrain.

  11. Quantum walks with an anisotropic coin I: spectral theory

    Science.gov (United States)

    Richard, S.; Suzuki, A.; Tiedra de Aldecoa, R.

    2018-02-01

    We perform the spectral analysis of the evolution operator U of quantum walks with an anisotropic coin, which include one-defect models, two-phase quantum walks, and topological phase quantum walks as special cases. In particular, we determine the essential spectrum of U, we show the existence of locally U-smooth operators, we prove the discreteness of the eigenvalues of U outside the thresholds, and we prove the absence of singular continuous spectrum for U. Our analysis is based on new commutator methods for unitary operators in a two-Hilbert spaces setting, which are of independent interest.

  12. Anisotropic mass density by two-dimensional acoustic metamaterials

    Energy Technology Data Exchange (ETDEWEB)

    Torrent, Daniel; Sanchez-Dehesa, Jose [Wave Phenomena Group, Department of Electronic Engineering, Polytechnic University of Valencia, C/Camino de Vera s/n, E-46022 Valencia (Spain)], E-mail: jsdehesa@upvnet.upv.es

    2008-02-15

    We show that specially designed two-dimensional arrangements of full elastic cylinders embedded in a nonviscous fluid or gas define (in the homogenization limit) a new class of acoustic metamaterials characterized by a dynamical effective mass density that is anisotropic. Here, analytic expressions for the dynamical mass density and the effective sound velocity tensors are derived in the long wavelength limit. Both show an explicit dependence on the lattice filling fraction, the elastic properties of cylinders relative to the background, their positions in the unit cell, and their multiple scattering interactions. Several examples of these metamaterials are reported and discussed.

  13. Anisotropic parameter inversion in VTI media using diffraction data

    KAUST Repository

    Waheed, Umair bin

    2013-09-22

    Diffracted waves contain useful information regarding the subsurface geometry and velocity. They are particularly valuable for anisotropic media as they inherently possess a wide range of dips necessary to resolve angular dependence of velocity. Using this property of diffraction data to our vantage, we develop an algorithm to invert for effective η model, assuming no prior knowledge of it. The obtained effective η model is then converted to interval η model using Dix-type inversion formula. The effectiveness of this approach is tested on the VTI Marmousi model, which yields good structural match even for a highly complex media such as the Marmousi model.

  14. On the lamb wave propagation in anisotropic laminated composite plates

    International Nuclear Information System (INIS)

    Park, Soo Keun; Jeong, Hyun Jo; Kim, Moon Saeng

    1998-01-01

    This paper examines the propagation of Lamb (or plate) waves in anisotropic laminated composite plates. The dispersion relations are explicitly derived using the classical plate theory (CLT), the first-order shear deformation theory (FSDT) and the exact solution (ES), Attention is paid to the lowest antisymmetric (flexural) and lowest symmetric(extensional) modes in the low frequency, long wavelength limit. Different values of shear correction factor were tested in FSDT and comparisons between flexural wave dispersion curves were made with exact results to asses the range of validity of approximate plate theories in the frequency domain.

  15. Aeroelastic modal dynamics of wind turbines including anisotropic effects

    Energy Technology Data Exchange (ETDEWEB)

    Fisker Skjoldan, P.

    2011-03-15

    Several methods for aeroelastic modal analysis of a rotating wind turbine are developed and used to analyse the modal dynamics of two simplified models and a complex model in isotropic and anisotropic conditions. The Coleman transformation is used to enable extraction of the modal frequencies, damping, and periodic mode shapes of a rotating wind turbine by describing the rotor degrees of freedom in the inertial frame. This approach is valid only for an isotropic system. Anisotropic systems, e.g., with an unbalanced rotor or operating in wind shear, are treated with the general approaches of Floquet analysis or Hill's method which do not provide a unique reference frame for observing the modal frequency, to which any multiple of the rotor speed can be added. This indeterminacy is resolved by requiring that the periodic mode shape be as constant as possible in the inertial frame. The modal frequency is thus identified as the dominant frequency in the response of a pure excitation of the mode observed in the inertial frame. A modal analysis tool based directly on the complex aeroelastic wind turbine code BHawC is presented. It uses the Coleman approach in isotropic conditions and the computationally efficient implicit Floquet analysis in anisotropic conditions. The tool is validated against system identifications with the partial Floquet method on the nonlinear BHawC model of a 2.3 MW wind turbine. System identification results show that nonlinear effects on the 2.3 MW turbine in most cases are small, but indicate that the controller creates nonlinear damping. In isotropic conditions the periodic mode shape contains up to three harmonic components, but in anisotropic conditions it can contain an infinite number of harmonic components with frequencies that are multiples of the rotor speed. These harmonics appear in calculated frequency responses of the turbine. Extreme wind shear changes the modal damping when the flow is separated due to an interaction between

  16. Anisotropic Expansion of a Thermal Dipolar Bose Gas.

    Science.gov (United States)

    Tang, Y; Sykes, A G; Burdick, N Q; DiSciacca, J M; Petrov, D S; Lev, B L

    2016-10-07

    We report on the anisotropic expansion of ultracold bosonic dysprosium gases at temperatures above quantum degeneracy and develop a quantitative theory to describe this behavior. The theory expresses the postexpansion aspect ratio in terms of temperature and microscopic collisional properties by incorporating Hartree-Fock mean-field interactions, hydrodynamic effects, and Bose-enhancement factors. Our results extend the utility of expansion imaging by providing accurate thermometry for dipolar thermal Bose gases. Furthermore, we present a simple method to determine scattering lengths in dipolar gases, including near a Feshbach resonance, through observation of thermal gas expansion.

  17. Quantum magnets with anisotropic infinite range random interactions.

    Science.gov (United States)

    Arrachea, Liliana; Rozenberg, Marcelo J

    2005-04-01

    Using exact diagonalization techniques, we study the dynamical response of the anisotropic disordered Heisenberg model for systems of S=1/2 spins with infinite range random exchange interactions at temperature T=0. The model can be considered as a generalization, to the quantum case, of the well-known Sherrington-Kirkpatrick classical spin glass model. We also compute and study the behavior of the Edwards Anderson order parameter and energy per spin as the anisotropy evolves from the Ising to the Heisenberg limits.

  18. Improvement of porcine cloning efficiency by trichostain A through early-stage induction of embryo apoptosis.

    Science.gov (United States)

    Ji, Qianqian; Zhu, Kongju; Liu, Zhiguo; Song, Zhenwei; Huang, Yuankai; Zhao, Haijing; Chen, Yaosheng; He, Zuyong; Mo, Delin; Cong, Peiqing

    2013-03-15

    Trichostain A (TSA), an inhibitor of histone deacetylases, improved developmental competence of SCNT embryos in many species, apparently by improved epigenetic reprogramming. The objective of the present study was to determine the effects of TSA-induced apoptosis in cloned porcine embryos. At various developmental stages, a comet assay and terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling staining were used to detect apoptosis, and real-time polymerase chain reaction was used to assess expression of genes related to apoptosis and pluripotency. In this study, TSA significantly induced apoptosis (in a dose-dependent manner) at the one-, two-, and four-cell stages. However, in blastocyst stage embryos, TSA decreased the apoptotic index (P < 0.05). Expression levels of Caspase 3 were higher in TSA-treated versus control embryos at the two-cell stage (not statistically significant). The expression ratio of antiapoptotic Bcl-xl gene to proapoptotic Bax gene, an indicator of antiapoptotic potential, was higher in TSA-treated groups at the one-, two-, and four-cell and blastocyst stages. Furthermore, expression levels of pluripotency-related genes, namely, Oct4 and Nanog, were elevated at the morula stage (P < 0.05) in TSA treatment groups. We concluded that inducing apoptosis might be a mechanism by which TSA promotes development of reconstructed embryos. At the initial stage of apoptosis induction, abnormal cells were removed, thereby enhancing proliferation of healthy cells and improving embryo quality. Copyright © 2013 Elsevier Inc. All rights reserved.

  19. Honey and Apoptosis in Human Gastric Mucosa

    Directory of Open Access Journals (Sweden)

    Alireza Ostadrahimi

    2012-07-01

    Full Text Available Background: Gastric cancer is the fourth most common malignancy in the world. Honey is acomplex mixture of special biological active constituents. Honey possesses antioxidant and antitumorproperties. Nutritional studies have indicated that consumption of honey modulates therisk of developing gastric cancer. On the other hand, apoptosis has been reported to play a decisiverole in precancerous changes. Our chief study was conducted to assess the relationship betweenconsumption of honey and apoptosis in human gastric mucosa.Method: This cross-sectional study was conducted on 98 subjects over 18 years old, referred totwo hospitals in Tabriz, Iran. Subjects were undergone an upper gastrointestinal endoscopy, 62subjects were finally enrolled. Honey consumption was assessed by a Food Frequency Questionnaire(FFQ and apoptosis was detected by TUNEL technique. We tested polynomial curve tofind the best fit between honey consumption and apoptosis.Results: A positive relation between honey consumption and apoptosis was found (P=0.024.Our results indicated that the final and the best fit curve was: apoptosis = 1.714+1.648(honeyamount - 0.533(honey amount2 +1.833×10-5(honey amount7.Conclusion: Honey consumption had positive effects on gastric cancer by inducing apoptosis ingastric mucosa.

  20. Grad-Shafranov reconstruction of Earth's magnetopause with anisotropic pressure

    Science.gov (United States)

    Chen, G. W.; Hau, L. N.

    2016-12-01

    Grad-Shafranov (GS) reconstruction is a technique to analyze the two-dimensional (2-D) coherent field structures of thin current sheets and by using this method one can construct the 2-D predicted values in an optimal co-moving frame from the data measured by a single spacecraft (Hau and Sonnerup, 1999). In this study we have developed and benchmarked a new GS solver based on the modified, extended Grad-Shafranov equations for the ideal magnetohydrodynamic (MHD) model with anisotropic plasma pressure (Hau and Sonnerup, 1993; Hau, 2002; Sonnerup et al., 2006), and applied it to the magnetopause crossing events observed by THEMIS spacecraft. The new GS solver can give rise to the 2-D spatial information of perpendicular and parallel plasma pressures for various thermodynamic conditions described by a set of double polytropic energy laws. We also compare the results based on isotropic and anisotropic GS solvers to examine the effects of pressure anisotropy on the reconstructed 2-D magnetopause structure.