LENUS (Irish Health Repository)
Huber, Heinrich J
2010-01-01
ABSTRACT: BACKGROUND: Apoptosis is an essential cell death process throughout the entire life span of all metazoans and its deregulation in humans has been implicated in many proliferative and degenerative diseases. Mitochondrial outer membrane permeabilisation (MOMP) and activation of effector caspases are key processes during apoptosis signalling. MOMP can be subject to spatial coordination in human cancer cells, resulting in intracellular waves of cytochrome-c release. To investigate the consequences of these spatial anisotropies in mitochondrial permeabilisation on subsequent effector caspase activation, we devised a mathematical reaction-diffusion model building on a set of partial differential equations. RESULTS: Reaction-diffusion modelling suggested that even if strong spatial anisotropies existed during mitochondrial cytochrome c release, these would be eliminated by free diffusion of the cytosolic proteins that instantiate the apoptosis execution network. Experimentally, rapid sampling of mitochondrial permeabilisation and effector caspase activity in individual HeLa cervical cancer cells confirmed predictions of the reaction-diffusion model and demonstrated that the signalling network of apoptosis execution could efficiently translate spatial anisotropies in mitochondrial permeabilisation into a homogeneous effector caspase response throughout the cytosol. Further systems modelling suggested that a more than 10,000-fold impaired diffusivity would be required to maintain spatial anisotropies as observed during mitochondrial permeabilisation until the time effector caspases become activated. CONCLUSIONS: Multi-protein diffusion efficiently contributes to eliminating spatial asynchronies which are present during the initiation of apoptosis execution and thereby ensures homogeneous apoptosis execution throughout the entire cell body. For previously reported biological scenarios in which effector caspase activity was shown to be targeted selectively to
The Initial State of a Primordial Anisotropic Stage of Inflation
Blanco-Pillado, Jose J.; Minamitsuji, Masato
2015-06-01
We investigate the possibility that the inflationary period in the early universe was preceded by a primordial stage of strong anisotropy. In particular we focus on the simplest model of this kind, where the spacetime is described by a non-singular Kasner solution that quickly evolves into an isotropic de Sitter space, the so-called Kasner-de Sitter solution. The initial Big Bang singularity is replaced, in this case, by a horizon. We show that the extension of this metric to the region behind the horizon contains a timelike singularity which will be visible by cosmological observers. This makes it impossible to have a reliable prediction of the quantum state of the cosmological perturbations in the region of interest. In this paper we consider the possibility that this Kasner-de Sitter universe is obtained as a result of a quantum tunneling process effectively substituting the region behind the horizon by an anisotropic parent vacuum state, namely a 1+1 dimensional spacetime compactified over an internal flat torus, T2, which we take it to be of the form de Sitter2 × T2 or Minkowski2 × T2. As a first approximation to understand the effects of this anisotropic initial state, we compute the power spectrum of a massless scalar field in these backgrounds. In both cases, the spectrum converges at small scales to the isotropic scale invariant form and only present important deviations from it at the largest possible scales. We find that the decompactification scenario from M2 × T2 leads to a suppressed and slightly anisotropic power spectrum at large scales which could be related to some of the anomalies present in the current CMB data. On the other hand, the spectrum of the universe with a dS2 × T2 parent vacuum presents an enhancement in power at large scales not consistent with observations.
An analytic approach to perturbations from an initially anisotropic universe
Kim, Hyeong-Chan
2011-01-01
We present the analytic forms for the spectra of the cosmological perturbations from an initially anisotropic universe for the high momentum modes in the context of WKB approximations, as the continuation of the work [29]. We consider the Einstein gravity coupled to a light scalar field. We then assume that the scalar field has the zero velocity initially and then slowly rolls down on the potential toward the origin. In the slow-roll approximations, the Kasner-de Sitter universe with a planar symmetry is a good approximation as the background evolution. Quantization of the perturbations in the adiabatic vacuum, which we call the anisotropic vacuum, is carried out. For non-planar high momentum modes whose comoving momentum component orthogonal to the plane is bigger than the Hubble parameter at the inflationary phase, the WKB approximation is valid for the whole stage of the isotropization. On the other hand, the planar modes whose comoving momentum component orthogonal to the plane is comparable to the Hubble...
The Initial State of a Primordial Anisotropic Stage of Inflation
Energy Technology Data Exchange (ETDEWEB)
Blanco-Pillado, Jose J. [Department of Theoretical Physics, University of the Basque Country UPV/EHU,48080 Bilbao (Spain); IKERBASQUE, Basque Foundation for Science,Maria Diaz de Haro 3, 48013 Bilbao (Spain); Minamitsuji, Masato [Yukawa Institute for Theoretical Physics, Kyoto University,Kitashirakawa-Oiwakecho, Sakyo-Ku, Kyoto 606-8502 (Japan); CENTRA, Instituto Superior Tecnico, Universidade de Lisboa,Avenida Rovisco Pais 1, 1049-001 Lisboa (Portugal)
2015-06-12
We investigate the possibility that the inflationary period in the early universe was preceded by a primordial stage of strong anisotropy. In particular we focus on the simplest model of this kind, where the spacetime is described by a non-singular Kasner solution that quickly evolves into an isotropic de Sitter space, the so-called Kasner-de Sitter solution. The initial Big Bang singularity is replaced, in this case, by a horizon. We show that the extension of this metric to the region behind the horizon contains a timelike singularity which will be visible by cosmological observers. This makes it impossible to have a reliable prediction of the quantum state of the cosmological perturbations in the region of interest. In this paper we consider the possibility that this Kasner-de Sitter universe is obtained as a result of a quantum tunneling process effectively substituting the region behind the horizon by an anisotropic parent vacuum state, namely a 1+1 dimensional spacetime compactified over an internal flat torus, T{sub 2}, which we take it to be of the form de Sitter{sub 2}×T{sub 2} or Minkowski{sub 2}×T{sub 2}. As a first approximation to understand the effects of this anisotropic initial state, we compute the power spectrum of a massless scalar field in these backgrounds. In both cases, the spectrum converges at small scales to the isotropic scale invariant form and only present important deviations from it at the largest possible scales. We find that the decompactification scenario from M{sub 2}×T{sub 2} leads to a suppressed and slightly anisotropic power spectrum at large scales which could be related to some of the anomalies present in the current CMB data. On the other hand, the spectrum of the universe with a dS{sub 2}×T{sub 2} parent vacuum presents an enhancement in power at large scales not consistent with observations.
The Initial State of a Primordial Anisotropic Stage of Inflation
Blanco-Pillado, Jose J
2015-01-01
We investigate the possibility that the inflationary period in the early universe was preceded by a primordial stage of strong anisotropy. In particular we focus on the simplest model of this kind, where the spacetime is described by a non-singular Kasner solution that quickly evolves into an isotropic de Sitter space, the so-called Kasner-de Sitter solution. The initial Big Bang singularity is replaced, in this case, by a horizon. We show that the extension of this metric to the region behind the horizon contains a timelike singularity which will be visible by cosmological observers. This makes it impossible to have a reliable prediction of the quantum state of the cosmological perturbations in the region of interest. In this paper we consider the possibility that this Kasner-de Sitter universe is obtained as a result of a quantum tunneling process effectively substituting the region behind the horizon by an anisotropic parent vacuum state, namely a $1+1$ dimensional spacetime compactified over an internal f...
Constitutive relation of weakly anisotropic polycrystal with microstructure and initial stress
Institute of Scientific and Technical Information of China (English)
Mojia Huang; Hua Zhan; Xiuqiao Lin; Hai Tang
2007-01-01
Man (Nondestr Test Eval 15:191-214, 1999) derived the constitutive relation of a weakly-textured orthorhombic aggregate of cubic crystallites with effects of microstructure and initial stress. In this paper, a computational expression on the integration ∫SO(3)Qh× Dl m0 is given. Then, by means of the computational expression, the general constitutive relation of a weakly-textured anisotropic polycrystal with the consideration of microstructure and initial stress is derived. As special cases of our general constitutive relation, two constitutive relations are given for an isotropic polycrystal and a weakly-textured anisotropic aggregate of cubic crystallites. The acoustoelastic tensor of the reference cubic crystal is derived to determine the material constants of the polycrystal. Two examples are given for understanding the physical meaning of the texture coefficients and the constitutive relations.
Effect of initial stress on reflection at the free surface of anisotropic elastic medium
Indian Academy of Sciences (India)
M D Sharma
2007-12-01
The propagation of plane waves is considered in a general anisotropic elastic medium in the presence of initial stress. The Christoffel equations are solved into a polynomial of degree six. The roots of this polynomial represent the vertical slowness values for the six quasi-waves resulting from the presence of a discontinuity in the medium. Three of these six values are identified with the three quasi-waves traveling in the medium but away from its boundary. Reflection at the free plane surface is studied for partition of energy among the three reflected waves. For post-critical incidence, the reflected waves are inhomogeneous (evanescent) waves. Numerical examples are considered to exhibit the effects of initial stress on the phase direction, attenuation and reflection coefficients of the reflected waves. The phase velocities and energy shares of the reflected waves change significantly with initial stress as well as anisotropic symmetry. The presence of initial stress, however, has a negligible effect on the phase directions of reflected waves.
International Nuclear Information System (INIS)
Ultra-Relativistic heavy-ion physics is a promising field of high energy physics connecting two fields: nuclear physics and elementary particle physics. Experimental achievements of the last years have provided an opportunity to study the properties of a new state of matter created in heavy-ion collisions called quark-gluon plasma. The initial state of two colliding nuclei is affected by fluctuations coming from wave- functions of nucleons. These fluctuations lead to the momentum anisotropy of the hadronic matter which is observed by the detectors. The system created in the collision behaves like a fluid, so the initial state is connected to the final state via hydrodynamic evolution. In this thesis we model the evolution with relativistic viscous hydrodynamics. Our results, combined with experimental data, give non trivial constraints on the initial state, thus achieving 'reverse engineering' of the heavy-ion collisions. The observable which characterizes the momentum anisotropy is the anisotropic flow vn. We present the first measurements of the first harmonic of the anisotropic flow called directed flow v1 in Pb-Pb collisions at the LHC. We then perform the first viscous hydrodynamic modeling of directed flow and show that it is less sensitive to viscosity than higher harmonics. Comparison of these experimental data with the modeling allows to extract the values of the dipole asymmetry of the initial state, which provides constraints on the models of initial states. A prediction for directed flow v1 in Au-Au collisions is also made for RHIC. We then perform a similar modeling of the second and third harmonics of the anisotropic flow, called respectively elliptic v2 and triangular v3 flow. A combined analysis of the elliptic and triangular flow data compared with viscous hydrodynamic calculations allows us to put constraints on initial ellipticity and triangularity of the system. These constraints are then used as a filter for different models of
Geminate ion recombination in anisotropic media. Effects of initial distribution and external field
International Nuclear Information System (INIS)
Recently we presented [Chem. Phys. Lett. 142, 385 (1987)] a method for calculating the diffusion-controlled geminate escape probability of an ion pair in an anisotropic medium. The escape probability depends on both the length and the direction of the initial interion vector, and is reducible to a function of two dimensionless variables describing the overall anisotropy of the medium. In this paper the treatment is extended to include an initial distribution of interion distances and an external field. Inclusion of a field increases the number of independently variable parameters to five: two to describe the anisotropy of the medium and three to describe the intensity and direction of the applied field. It is shown that the effects of including anisotropy are not negligible for the typical case of anthracene and that the slope-to-intercept ratio of the field-dependent escape probability for a spherically averaged distribution depends on the direction of the applied field
Directory of Open Access Journals (Sweden)
Rodriguez-Gallego Carlos
2010-09-01
Full Text Available Abstract Background DNA-damage assays, quantifying the initial number of DNA double-strand breaks induced by radiation, have been proposed as a predictive test for radiation-induced toxicity. Determination of radiation-induced apoptosis in peripheral blood lymphocytes by flow cytometry analysis has also been proposed as an approach for predicting normal tissue responses following radiotherapy. The aim of the present study was to explore the association between initial DNA damage, estimated by the number of double-strand breaks induced by a given radiation dose, and the radio-induced apoptosis rates observed. Methods Peripheral blood lymphocytes were taken from 26 consecutive patients with locally advanced breast carcinoma. Radiosensitivity of lymphocytes was quantified as the initial number of DNA double-strand breaks induced per Gy and per DNA unit (200 Mbp. Radio-induced apoptosis at 1, 2 and 8 Gy was measured by flow cytometry using annexin V/propidium iodide. Results Radiation-induced apoptosis increased in order to radiation dose and data fitted to a semi logarithmic mathematical model. A positive correlation was found among radio-induced apoptosis values at different radiation doses: 1, 2 and 8 Gy (p Conclusions An inverse association was observed for the first time between these variables, both considered as predictive factors to radiation toxicity.
Stender, Michael E; Regueiro, Richard A; Klisch, Stephen M; Ferguson, Virginia L
2015-08-01
Traumatic injuries and gradual wear-and-tear of articular cartilage (AC) that can lead to osteoarthritis (OA) have been hypothesized to result from tissue damage to AC. In this study, a previous equilibrium constitutive model of AC was extended to a constitutive damage articular cartilage (CDAC) model. In particular, anisotropic collagen (COL) fibril damage and isotropic glycosaminoglycan (GAG) damage were considered in a 3D formulation. In the CDAC model, time-dependent effects, such as viscoelasticity and poroelasticity, were neglected, and thus all results represent the equilibrium response after all time-dependent effects have dissipated. The resulting CDAC model was implemented in two different finite-element models. The first simulated uniaxial tensile loading to failure, while the second simulated spherical indentation with a rigid indenter displaced into a bilayer AC sample. Uniaxial tension to failure simulations were performed for three COL fibril Lagrangian failure strain (i.e., the maximum elastic COL fibril strain) values of 15%, 30%, and 45%, while spherical indentation simulations were performed with a COL fibril Lagrangian failure strain of 15%. GAG damage parameters were held constant for all simulations. Our results indicated that the equilibrium postyield tensile response of AC and the macroscopic tissue failure strain are highly dependent on COL fibril Lagrangian failure strain. The uniaxial tensile response consisted of an initial nonlinear ramp region due to the recruitment of intact fibrils followed by a rapid decrease in tissue stress at initial COL fibril failure, as a result of COL fibril damage which continued until ultimate tissue failure. In the spherical indentation simulation, damage to both the COL fibril and GAG constituents was located only in the superficial zone (SZ) and near the articular surface with tissue thickening following unloading. Spherical indentation simulation results are in agreement with published experimental
International Nuclear Information System (INIS)
DNA-damage assays, quantifying the initial number of DNA double-strand breaks induced by radiation, have been proposed as a predictive test for radiation-induced toxicity. Determination of radiation-induced apoptosis in peripheral blood lymphocytes by flow cytometry analysis has also been proposed as an approach for predicting normal tissue responses following radiotherapy. The aim of the present study was to explore the association between initial DNA damage, estimated by the number of double-strand breaks induced by a given radiation dose, and the radio-induced apoptosis rates observed. Peripheral blood lymphocytes were taken from 26 consecutive patients with locally advanced breast carcinoma. Radiosensitivity of lymphocytes was quantified as the initial number of DNA double-strand breaks induced per Gy and per DNA unit (200 Mbp). Radio-induced apoptosis at 1, 2 and 8 Gy was measured by flow cytometry using annexin V/propidium iodide. Radiation-induced apoptosis increased in order to radiation dose and data fitted to a semi logarithmic mathematical model. A positive correlation was found among radio-induced apoptosis values at different radiation doses: 1, 2 and 8 Gy (p < 0.0001 in all cases). Mean DSB/Gy/DNA unit obtained was 1.70 ± 0.83 (range 0.63-4.08; median, 1.46). A statistically significant inverse correlation was found between initial damage to DNA and radio-induced apoptosis at 1 Gy (p = 0.034). A trend toward 2 Gy (p = 0.057) and 8 Gy (p = 0.067) was observed after 24 hours of incubation. An inverse association was observed for the first time between these variables, both considered as predictive factors to radiation toxicity
International Nuclear Information System (INIS)
As a sequel to previous works on the definition of a positive frequency part of a quantized scalar field near an initial stage of several Robertson-Walker universes with flat, open or closed 3-space and the associated pair-creation of those particles, an attempt is made to seek for the same concept in several Bianchi-type I anisotropic universes. It is shown that, if the concept may be introduced, the pair-creation of scalar particles and their spectral law are uniquely settled, as in the case of isotropic universes. (author)
Leulmi, Selma; Chauchet, Xavier; Morcrette, Melissa; Ortiz, Guillermo; Joisten, Hélène; Sabon, Philippe; Livache, Thierry; Hou, Yanxia; Carrière, Marie; Lequien, Stéphane; Dieny, Bernard
2015-09-01
Cancer cells develop resistance to chemotherapy, and the side effects encountered seriously limit the effectiveness of treatments. For these reasons, the search for alternative therapies that target cancer cells without affecting healthy tissues is currently one of the most active areas of research on cancer. The present study focuses on a recently proposed approach for cancer cell destruction based on the targeted triggering of cancer cell spontaneous death through the mechanical vibration of anisotropic magnetic micro/nanoparticles attached to the cell membranes at low frequencies (~20 Hz) and in weak magnetic fields (~30 mT). The study was conducted in vitro, on human renal cancer cells with superparamagnetic-like particles. Three types of such particles made of NiFe or magnetite were prepared and characterized (either synthetic antiferromagnetic, vortex or polycrystalline with random grain anisotropy). The triggering of the apoptosis of these cancer cells was demonstrated with NiFe vortex particles and statistically characterized by flow-cytometry studies. The death pathway via apoptosis and not necrosis was identified by the clear observation of caspase activation.
Anisotropic non-Gaussianity from Rotational Symmetry Breaking Excited Initial States
Ashoorioon, Amjad; Casadio, Roberto; Koivisto, Tomi
2016-01-01
If the initial quantum state of the primordial perturbations broke rotational invariance, that would be seen as a statistical anisotropy in the angular correlations of the cosmic microwave background radiation (CMBR) temperature fluctuations. This can be described by a general parameterisation of the initial conditions that takes into account the possible direction-dependence of both the amplitude and the phase of particle creation during inflation. The leading effect in the CMBR two-point fu...
Apoptosis and cell-cycle arrest in human and murine tumor cells are initiated by isoprenoids.
Mo, H; Elson, C E
1999-04-01
Diverse classes of phytochemicals initiate biological responses that effectively lower cancer risk. One class of phytochemicals, broadly defined as pure and mixed isoprenoids, encompasses an estimated 22,000 individual components. A representative mixed isoprenoid, gamma-tocotrienol, suppresses the growth of murine B16(F10) melanoma cells, and with greater potency, the growth of human breast adenocarcinoma (MCF-7) and human leukemic (HL-60) cells. beta-Ionone, a pure isoprenoid, suppresses the growth of B16 cells and with greater potency, the growth of MCF-7, HL-60 and human colon adenocarcinoma (Caco-2) cells. Results obtained with diverse cell lines differing in ras and p53 status showed that the isoprenoid-mediated suppression of growth is independent of mutated ras and p53 functions. beta-Ionone suppressed the growth of human colon fibroblasts (CCD-18Co) but only when present at three-fold the concentration required to suppress the growth of Caco-2 cells. The isoprenoids initiated apoptosis and, concomitantly arrested cells in the G1 phase of the cell cycle. Both suppress 3-hydroxy-3-methylglutaryl CoA reductase activity. beta-Ionone and lovastatin interfered with the posttranslational processing of lamin B, an activity essential to assembly of daughter nuclei. This interference, we postulate, renders neosynthesized DNA available to the endonuclease activities leading to apoptotic cell death. Lovastatin-imposed mevalonate starvation suppressed the glycosylation and translocation of growth factor receptors to the cell surface. As a consequence, cells were arrested in the G1 phase of the cell cycle. This rationale may apply to the isoprenoid-mediated G1-phase arrest of tumor cells. The additive and potentially synergistic actions of these isoprenoids in the suppression of tumor cell proliferation and initiation of apoptosis coupled with the mass action of the diverse isoprenoid constituents of plant products may explain, in part, the impact of fruit, vegetable
Anisotropic non-Gaussianity from Rotational Symmetry Breaking Excited Initial States
Ashoorioon, Amjad; Koivisto, Tomi
2016-01-01
If the initial quantum state of the primordial perturbations broke rotational invariance, that would be seen as a statistical anisotropy in the angular correlations of the cosmic microwave background radiation (CMBR) temperature fluctuations. This can be described by a general parameterisation of the initial conditions that takes into account the possible direction-dependence of both the amplitude and the phase of particle creation during inflation. The leading effect in the CMBR two-point function is typically a quadrupole modulation, whose coefficient is analytically constrained here to be $|B| \\lesssim 0.06$. The CMBR three-point function then acquires enhanced non-gaussianity, especially for the local configurations. In the large occupation number limit, a distinctive prediction is a modulation of the non-gaussianity around a mean value depending on the angle that short and long wavelength modes make with the preferred direction. The maximal variations with respect to the mean value occur for the configur...
Barrow, John D.; Ganguly, Chandrima
2016-06-01
We study the behaviour of Bianchi class A universes containing an ultra-stiff isotropic ghost field and a fluid with anisotropic pressures which is also ultra-stiff on the average. This allows us to investigate whether cyclic universe scenarios, like the ekpyrotic model, do indeed lead to isotropization on approach to a singularity (or bounce) in the presence of dominant ultra-stiff pressure anisotropies. We specialize to consider the closed Bianchi type IX universe, and show that when the anisotropic pressures are stiffer on average than any isotropic ultra-stiff fluid then, if they dominate on approach to the singularity, it will be anisotropic. We include an isotropic ultra-stiff ghost fluid with negative energy density in order to create a cosmological bounce at finite volume in the absence of the anisotropic fluid. When the dominant anisotropic fluid is present it leads to an anisotropic cosmological singularity rather than an isotropic bounce. The inclusion of anisotropic stresses generated by collisionless particles in an anisotropically expanding universe is therefore essential for a full analysis of the consequences of a cosmological bounce or singularity in cyclic universes.
Barrow, John D
2015-01-01
We study the behaviour of Bianchi class A universes containing an ultra-stiff isotropic ghost field and a fluid with anisotropic pressures which is also ultra-stiff on the average. This allows us to investigate whether cyclic universe scenarios, like the ekpyrotic model, do indeed lead to isotropisation on approach to a singularity (or bounce) in the presence of dominant ultra-stiff pressure anisotropies. We specialise to consider the closed Bianchi type IX universe and show that when the anisotropic pressures are stiffer on average than any isotropic ultra-stiff fluid then, if they dominate on approach to the singularity, it will be anisotropic. We include an isotropic ultra-stiff ghost fluid with negative energy density in order to create a cosmological bounce at finite volume in the absence of the anisotropic fluid. When the dominant anisotropic fluid is present it leads to an anisotropic cosmological singularity rather than an isotropic bounce. The inclusion of anisotropic stresses generated by collisionl...
Analysis of Residual DSBs in Ataxia-Telangiectasia Lymphoblast Cells Initiating Apoptosis
Directory of Open Access Journals (Sweden)
Teresa Anglada
2016-01-01
Full Text Available In order to examine the relationship between accumulation of residual DNA double-strand breaks (DSBs and cell death, we have used a control and an ATM (Ataxia-Telangiectasia Mutated defective cell line, as Ataxia-Telangiectasia (AT cells tend to accumulate residual DSBs at long times after damage infliction. After irradiation, AT cells showed checkpoint impairment and a fraction of cells displayed an abnormal centrosome number and tetraploid DNA content, and this fraction increased along with apoptosis rates. At all times analyzed, AT cells displayed a significantly higher rate of radiation-induced apoptosis than normal cells. Besides apoptosis, 70–85% of the AT viable cells (TUNEL-negative carried ≥10 γH2AX foci/cell, while only 12–27% of normal cells did. The fraction of AT and normal cells undergoing early and late apoptosis were isolated by flow cytometry and residual DSBs were concretely scored in these populations. Half of the γH2AX-positive AT cells undergoing early apoptosis carried ≥10 γH2AX foci/cell and this fraction increased to 75% in late apoptosis. The results suggest that retention of DNA damage-induced γH2AX foci is an indicative of lethal DNA damage, as cells undergoing apoptosis are those accumulating more DSBs. Scoring of residual γH2AX foci might function as a predictive tool to assess radiation-induced apoptosis.
Sendler, Matthias; Maertin, Sandrina; John, Daniel; Persike, Maria; Weiss, F Ulrich; Krüger, Burkhard; Wartmann, Thomas; Wagh, Preshit; Halangk, Walter; Schaschke, Norbert; Mayerle, Julia; Lerch, Markus M
2016-07-01
Pancreatitis is associated with premature activation of digestive proteases in the pancreas. The lysosomal hydrolase cathepsin B (CTSB) is a known activator of trypsinogen, and its deletion reduces disease severity in experimental pancreatitis. Here we studied the activation mechanism and subcellular compartment in which CTSB regulates protease activation and cellular injury. Cholecystokinin (CCK) increased the activity of CTSB, cathepsin L, trypsin, chymotrypsin, and caspase 3 in vivo and in vitro and induced redistribution of CTSB to a secretory vesicle-enriched fraction. Neither CTSB protein nor activity redistributed to the cytosol, where the CTSB inhibitors cystatin-B/C were abundantly present. Deletion of CTSB reduced and deletion of cathepsin L increased intracellular trypsin activation. CTSB deletion also abolished CCK-induced caspase 3 activation, apoptosis-inducing factor, as well as X-linked inhibitor of apoptosis protein degradation, but these depended on trypsinogen activation via CTSB. Raising the vesicular pH, but not trypsin inhibition, reduced CTSB activity. Trypsin inhibition did not affect apoptosis in hepatocytes. Deletion of CTSB affected apoptotic but not necrotic acinar cell death. In summary, CTSB in pancreatitis undergoes activation in a secretory, vesicular, and acidic compartment where it activates trypsinogen. Its deletion or inhibition regulates acinar cell apoptosis but not necrosis in two models of pancreatitis. Caspase 3-mediated apoptosis depends on intravesicular trypsinogen activation induced by CTSB, not CTSB activity directly, and this mechanism is pancreas-specific. PMID:27226576
Liu, Chun-Tao; Xin, Ying; Tong, Chun-Yan; Li, Bing; Bao, Hong-Li; Zhang, Cai-Yun; Wang, Xue-Hui
2016-06-01
The cancer stem cell (CSC) theory suggests that cancer growth and invasion is dictated by the small population of CSCs within the heterogenous tumor. The aim of the present study was to elucidate the cause for chemotherapy failure and the resistance of CSCs to apoptosis. A total of ~2.3% cluster of differentiation (CD)133+ cancer stem‑like side population (SP) cells were identified in cases of uterine cervical cancer. These CD133+ SP cells were found to potently initiate tumor growth and invasion, as they exhibit transcriptional upregulation of stemness genes, including octamer‑binding transcription factor‑4, B‑cell‑specific Moloney murine leukemia virus insertion site‑1, epithelial cell adhesion molecule, (sex determining region Y)‑box 2, Nestin and anti‑apoptotic B cell lymphoma‑2. In addition, the CD133+ SP cells showed resistance to multi‑drug treatment and apoptosis. The present study further showed that the secretion of interleukin‑4 (IL‑4) in CD133+ cervical cancer SP cells promoted cell proliferation and prevented the SP cells from apoptosis. Following the neutralization of IL‑4 with anti‑IL‑4 antibody, the CD133+ SP cells were more sensitive to drug treatment and apoptosis. Therefore, the data obtained in the present study suggested that the autocrine secretion of IL‑4 promotes increased survival and resistance to cell death in CSCs. PMID:27121303
Energy Technology Data Exchange (ETDEWEB)
Yamaguchi, Akinobu, E-mail: yamaguti@lasti.u-hyogo.ac.jp, E-mail: utsumi@lasti.u-hyogo.ac.jp; Kido, Hideki; Utsumi, Yuichi, E-mail: yamaguti@lasti.u-hyogo.ac.jp, E-mail: utsumi@lasti.u-hyogo.ac.jp [University of Hyogo, 3-1-2 Kouto, Kamigori, Ako, Hyogo 678-1205 (Japan); Ukita, Yoshiaki [University of Yamanashi, 4-3-11 Takeda, Kohfu, Yamanashi 400-8511 (Japan); Kishihara, Mitsuyoshi [Okayama Prefectural University, 111 Kuboki, Sousha, Okayama 719-1197 (Japan)
2016-02-01
We developed a process for micromachining polytetrafluoroethylene (PTFE): anisotropic pyrochemical microetching induced by synchrotron X-ray irradiation. X-ray irradiation was performed at room temperature. Upon heating, the irradiated PTFE substrates exhibited high-precision features. Both the X-ray diffraction peak and Raman signal from the irradiated areas of the substrate decreased with increasing irradiation dose. The etching mechanism is speculated as follows: X-ray irradiation caused chain scission, which decreased the number-average degree of polymerization. The melting temperature of irradiated PTFE decreased as the polymer chain length decreased, enabling the treated regions to melt at a lower temperature. The anisotropic pyrochemical etching process enabled the fabrication of PTFE microstructures with higher precision than simultaneously heating and irradiating the sample.
In-plane anisotropic deformation behavior of rolled Mg–3Al–1Zn alloy by initial {10–12} twins
International Nuclear Information System (INIS)
In-plane deformation characteristics of rolled Mg–3Al–1Zn alloy, which was previously compressed along the rolling direction, were investigated by carrying out tension and compression tests in combination with the in-situ electron backscatter diffraction technique and Schmid factor (SF) analysis. The specific crystallographic orientation of twinned regions (i.e., twin texture), caused by the {10–12} twinning during the pre-compression, gave rise to in-plane anisotropic activities of slips and twinning by affecting their SF and this led to an anisotropy in in-plane deformation characteristics of the pre-compressed material. The amount of the pre-compression was also found to be important in the deformation because it is directly related to the volume fractions of twinned and untwined regions, {10–12} twin boundary induced grain size change, and dislocation interaction related hardening. By considering the combined effects of active deformation modes in twinned and untwined regions, volume fractions of twinned and untwined regions, Hall–Petch hardening for slips and twinning, and dislocation interaction related hardening, the deformation characteristics of the pre-compressed material were successfully interpreted. In addition, the combined effect of the SF and grain size (i.e., the Hall–Petch hardening for twinning) was found to control the twinning behavior, when subjected to the condition where multiple twinning modes are possible
Some ABCA3 mutations elevate ER stress and initiate apoptosis of lung epithelial cells
Directory of Open Access Journals (Sweden)
Holzinger Andreas
2011-01-01
Full Text Available Abstract Background ABCA3 transporter (ATP-binding cassette transporter of the A subfamily is localized to the limiting membrane of lamellar bodies, organelles for assembly and storage of pulmonary surfactant in alveolar epithelial type II cells (AECII. It transports surfactant phospholipids into lamellar bodies and absence of ABCA3 function disrupts lamellar body biogenesis. Mutations of the ABCA3 gene lead to fatal neonatal surfactant deficiency and chronic interstitial lung disease (ILD of children. ABCA3 mutations can result in either functional defects of the correctly localized ABCA3 or trafficking/folding defects where mutated ABCA3 remains in the endoplasmic reticulum (ER. Methods Human alveolar epithelial A549 cells were transfected with vectors expressing wild-type ABCA3 or one of the three ABCA3 mutant forms, R43L, R280C and L101P, C-terminally tagged with YFP or hemagglutinin-tag. Localization/trafficking properties were analyzed by immunofluorescence and ABCA3 deglycosylation. Uptake of fluorescent NBD-labeled lipids into lamellar bodies was used as a functional assay. ER stress and apoptotic signaling were examined through RT-PCR based analyses of XBP1 splicing, immunoblotting or FACS analyses of stress/apoptosis proteins, Annexin V surface staining and determination of the intracellular glutathion level. Results We demonstrate that two ABCA3 mutations, which affect ABCA3 protein trafficking/folding and lead to partial (R280C or complete (L101P retention of ABCA3 in the ER compartment, can elevate ER stress and susceptibility to it and induce apoptotic markers in the cultured lung epithelial A549 cells. R43L mutation, resulting in a functional defect of the properly localized ABCA3, had no effect on intracellular stress and apoptotic signaling. Conclusion Our data suggest that expression of partially or completely ER localized ABCA3 mutant proteins can increase the apoptotic cell death of the affected cells, which are factors that
Directory of Open Access Journals (Sweden)
Chuturgoon Anil A
2011-11-01
Full Text Available Abstract Background Rheumatoid arthritis (RA is a chronic autoimmune disease, which causes synovial damage. Persistence of lymphocyte infiltrates in the rheumatoid synovium has been attributed to abnormal apoptosis. While not comprehensively investigated, perturbations in peripheral blood lymphocyte (PBL apoptosis may also be involved in perpetuation of autoimmune processes in RA. Methods We investigated total, CD4+ and CD19+ PBL apoptosis in our study cohort by monitoring the translocation of phosphatidylserine using the Annexin-V assay. To examine the role of death receptor mediated apoptosis as well as activation-induced-cell-death (AICD, PBLs were labeled with CD95/Fas and CD69 markers and enumerated by flow cytometry. Proteolytic activity of initiator and executioner caspases was determined by luminometry. DNA fragmentation assays were used to examine whether apoptotic signals were transduced to the nucleus. Quantitative PCR arrays were used to investigate apoptotic pathways associated with RA-PBLs. Since heat-shock-protein-70 (HSP70 is an inducible protein which modulates apoptotic signals, we determined HSP70 levels by intra-cellular flow cytometry and western blots. Results The RA-PBLs showed signs of elevated apoptosis whilst in circulation. These include increases in the loss of plasma membrane asymmetry, indicated by increased externalization of phosphatidylserine (especially in B-lymphocytes. RA-PBLs showed a bias to CD95/Fas mediated apoptotic pathways, but low levels of the CD69 marker suggested that this was not associated with immune activation. Although downstream markers of apoptosis such as caspase-3/7 activity, were increased, no DNA fragmentation was observed in RA-PBLs. Interestingly, elevated levels of apoptosis did not correlate with absolute lymphocyte counts in RA patients. Levels of HSP70 were highly elevated in RA-PBLs compared to controls. Conclusion The results suggest that while apoptosis may be initiated in RA
Dynamical analysis of anisotropic inflation
Karčiauskas, Mindaugas
2016-06-01
The inflaton coupling to a vector field via the f(φ)2F μνFμν term is used in several contexts in the literature, such as to generate primordial magnetic fields, to produce statistically anisotropic curvature perturbation, to support anisotropic inflation, and to circumvent the η-problem. In this work, I perform dynamical analysis of this system allowing for the most general Bianchi I initial conditions. I also confirm the stability of attractor fixed points along phase-space directions that had not been investigated before.
Volate, Suresh R.; Kawasaki, Brian T.; Hurt, Elaine M.; Milner, John A.; Kim, Young S.; White, Jeffrey; Farrar, William L.
2010-01-01
Prostate cancer (PCa) continues to represent a burgeoning medical problem in the United States. Recent studies suggest that gossypol, a bioactive phytochemical produced by cotton plants, is a promising agent against prostate cancer. The current studies were undertaken to examine the chemotherapeutic efficacy of gossypol on human prostate cancer cell lines and prostate tumor-initiating cells (pTICs). Gossypol reduced viability of three prostate cancer cell lines (LAPC4, PC3, and DU145) with an...
Energy Technology Data Exchange (ETDEWEB)
Wang, J. [The First Affiliated Hospital, Liaoning Medical University, Jinzhou (China); Key Laboratory of Cardiovascular and Cerebrovascular Drug Research, Liaoning Province, Liaoning Medical University, Jinzhou (China); Lu, M.L.; Dai, H.L.; Zhang, S.P.; Wang, H.X. [Key Laboratory of Cardiovascular and Cerebrovascular Drug Research, Liaoning Province, Liaoning Medical University, Jinzhou (China); Wei, N. [The First Affiliated Hospital, Liaoning Medical University, Jinzhou (China)
2014-12-12
This study investigated the in vitro and in vivo antiproliferative activity of esculetin against hepatocellular carcinoma, and clarified its potential molecular mechanisms. Cell viability was determined by the MTT (tetrazolium) colorimetric assay. In vivo antitumor activity of esculetin was evaluated in a hepatocellular carcinoma mouse model. Seventy-five C57BL/6J mice were implanted with Hepa1-6 cells and randomized into five groups (n=15 each) given daily intraperitoneal injections of vehicle (physiological saline), esculetin (200, 400, or 700 mg·kg{sup -1}·day{sup -1}), or 5-Fu (200 mg·kg{sup -1}·day{sup -1}) for 15 days. Esculetin significantly decreased tumor growth in mice bearing Hepa1-6 cells. Tumor weight was decreased by 20.33, 40.37, and 55.42% with increasing doses of esculetin. Esculetin significantly inhibited proliferation of HCC cells in a concentration- and time-dependent manner and with an IC{sub 50} value of 2.24 mM. It blocked the cell cycle at S phase and induced apoptosis in SMMC-7721 cells with significant elevation of caspase-3 and caspase-9 activity, but did not affect caspase-8 activity. Moreover, esculetin treatment resulted in the collapse of mitochondrial membrane potential in vitro and in vivo accompanied by increased Bax expression and decreased Bcl-2 expression at both transcriptional and translational levels. Thus, esculetin exerted in vitro and in vivo antiproliferative activity in hepatocellular carcinoma, and its mechanisms involved initiation of a mitochondrial-mediated, caspase-dependent apoptosis pathway.
Directory of Open Access Journals (Sweden)
J. Wang
2015-03-01
Full Text Available This study investigated the in vitro and in vivo antiproliferative activity of esculetin against hepatocellular carcinoma, and clarified its potential molecular mechanisms. Cell viability was determined by the MTT (tetrazolium colorimetric assay. In vivo antitumor activity of esculetin was evaluated in a hepatocellular carcinoma mouse model. Seventy-five C57BL/6J mice were implanted with Hepa1-6 cells and randomized into five groups (n=15 each given daily intraperitoneal injections of vehicle (physiological saline, esculetin (200, 400, or 700 mg·kg-1·day-1, or 5-Fu (200 mg·kg-1·day-1 for 15 days. Esculetin significantly decreased tumor growth in mice bearing Hepa1-6 cells. Tumor weight was decreased by 20.33, 40.37, and 55.42% with increasing doses of esculetin. Esculetin significantly inhibited proliferation of HCC cells in a concentration- and time-dependent manner and with an IC50 value of 2.24 mM. It blocked the cell cycle at S phase and induced apoptosis in SMMC-7721 cells with significant elevation of caspase-3 and caspase-9 activity, but did not affect caspase-8 activity. Moreover, esculetin treatment resulted in the collapse of mitochondrial membrane potential in vitro and in vivo accompanied by increased Bax expression and decreased Bcl-2 expression at both transcriptional and translational levels. Thus, esculetin exerted in vitro and in vivo antiproliferative activity in hepatocellular carcinoma, and its mechanisms involved initiation of a mitochondrial-mediated, caspase-dependent apoptosis pathway.
International Nuclear Information System (INIS)
This study investigated the in vitro and in vivo antiproliferative activity of esculetin against hepatocellular carcinoma, and clarified its potential molecular mechanisms. Cell viability was determined by the MTT (tetrazolium) colorimetric assay. In vivo antitumor activity of esculetin was evaluated in a hepatocellular carcinoma mouse model. Seventy-five C57BL/6J mice were implanted with Hepa1-6 cells and randomized into five groups (n=15 each) given daily intraperitoneal injections of vehicle (physiological saline), esculetin (200, 400, or 700 mg·kg-1·day-1), or 5-Fu (200 mg·kg-1·day-1) for 15 days. Esculetin significantly decreased tumor growth in mice bearing Hepa1-6 cells. Tumor weight was decreased by 20.33, 40.37, and 55.42% with increasing doses of esculetin. Esculetin significantly inhibited proliferation of HCC cells in a concentration- and time-dependent manner and with an IC50 value of 2.24 mM. It blocked the cell cycle at S phase and induced apoptosis in SMMC-7721 cells with significant elevation of caspase-3 and caspase-9 activity, but did not affect caspase-8 activity. Moreover, esculetin treatment resulted in the collapse of mitochondrial membrane potential in vitro and in vivo accompanied by increased Bax expression and decreased Bcl-2 expression at both transcriptional and translational levels. Thus, esculetin exerted in vitro and in vivo antiproliferative activity in hepatocellular carcinoma, and its mechanisms involved initiation of a mitochondrial-mediated, caspase-dependent apoptosis pathway
Indian Academy of Sciences (India)
Anup Saha; Santimoy Kundu; Shishir Gupta; Pramod Kumar Vaishnav
2016-06-01
The present paper is concerned with the propagation of torsional surface waves in an initially stressedanisotropic porous layer sandwiched between homogeneous and non-homogeneous half-space. We assumethe quadratic inhomogeneity in rigidity and density in the lower half-space and irregularity is taken inthe form of rectangle at the interface separating the layer from the lower half-space. The dispersionequation for torsional waves has been obtained in a closed form. Velocity equation is also obtained inthe absence of irregularity. The study reveals that the presence of irregularity, initial stress, porosity,inhomogeneity and anisotropy factor in the dispersion equation approves the significant effect of theseparameters in the propagation of torsional waves in porous medium. It has also been observed that fora uniform media, the velocity equation reduces to the classical result of Love wave.
Caspases: An apoptosis mediator
Directory of Open Access Journals (Sweden)
Tapan Kumar Palai
2015-03-01
Full Text Available The process of programmed cell death, or apoptosis, is generally characterized by distinct morphological characteristics and energy - dependent biochemical mechanisms. Apoptosis is a widely conserved phenomenon helping many processes, including normal cell turnover, proper development and functioning of the immune system, hormone dependent atrophy etc. Inappropriate apoptosis (either low level or high level leads to many developmental abnormalities like, neurodegenerative diseases, ischemic damage, autoimmune disorders and many types of cancer. To use cells for therapeutic purposes through generating cell lines, it is critical to study the cell cycle machinery and signalling pathways that controls cell death and apoptosis. Apoptotic pathways provide a fundamental protective mechanism that decreases cellular sensitivity to damaging events and allow proper developmental process in multi-cellular organisms. Major mediator of apoptosis is a family of proteins known as caspases. There are mainly fourteen types of caspases but out of them only ten caspasese have got essential role in controlling the process of apoptosis. These ten caspases have been categorized into either initiator caspases (caspase 2, 8, 9, 10 or executioner caspases (caspase 3, 6, 7. Although various types of caspases have been identified so far, the exact mechanisms of action of these groups of proteins is still to be fully understood. The aim of this review is to provide a detail overview of role of different caspases in regulating the process of apoptosis.
Anisotropic Stars II Stability
Dev, K; Dev, Krsna; Gleiser, Marcelo
2003-01-01
We investigate the stability of self-gravitating spherically symmetric anisotropic spheres under radial perturbations. We consider both the Newtonian and the full general-relativistic perturbation treatment. In the general-relativistic case, we extend the variational formalism for spheres with isotropic pressure developed by Chandrasekhar. We find that, in general, when the tangential pressure is greater than the radial pressure, the stability of the anisotropic sphere is enhanced when compared to isotropic configurations. In particular, anisotropic spheres are found to be stable for smaller values of the adiabatic index $\\gamma$.
A BEM FOR TRANSIENT HEAT CONDUCTION PROBLEM OF ANISOTROPIC FGM
Azis, Mohammad Ivan
2014-01-01
A boundary element method (BEM) for the solution of a certain class of nonlinear parabolic initial boundary value problems for a certain class of anisotropic functionally graded media is derived. The method is then used to obtain numerical values for some particular transient 2-D heat conduction problems for anisotropic functionally graded materials (FGM).
Averaging anisotropic cosmologies
International Nuclear Information System (INIS)
We examine the effects of spatial inhomogeneities on irrotational anisotropic cosmologies by looking at the average properties of anisotropic pressure-free models. Adopting the Buchert scheme, we recast the averaged scalar equations in Bianchi-type form and close the standard system by introducing a propagation formula for the average shear magnitude. We then investigate the evolution of anisotropic average vacuum models and those filled with pressureless matter. In the latter case we show that the backreaction effects can modify the familiar Kasner-like singularity and potentially remove Mixmaster-type oscillations. The presence of nonzero average shear in our equations also allows us to examine the constraints that a phase of backreaction-driven accelerated expansion might put on the anisotropy of the averaged domain. We close by assessing the status of these and other attempts to define and calculate 'average' spacetime behaviour in general relativity
Anisotropic Metamaterial Optical Fibers
Pratap, Dheeraj; Pollock, Justin G; Iyer, Ashwin K
2014-01-01
Internal physical structure can drastically modify the properties of waveguides: photonic crystal fibers are able to confine light inside a hollow air core by Bragg scattering from a periodic array of holes, while metamaterial loaded waveguides for microwaves can support propagation at frequencies well below cutoff. Anisotropic metamaterials assembled into cylindrically symmetric geometries constitute light-guiding structures that support new kinds of exotic modes. A microtube of anodized nanoporous alumina, with nanopores radially emanating from the inner wall to the outer surface, is a manifestation of such an anisotropic metamaterial optical fiber. The nanopores, when filled with a plasmonic metal such as silver or gold, greatly increase the electromagnetic anisotropy. The modal solutions in anisotropic circular waveguides can be uncommon Bessel functions with imaginary orders.
Hwu, Chyanbin
2010-01-01
As structural elements, anisotropic elastic plates find wide applications in modern technology. The plates here are considered to be subjected to not only in plane load but also transverse load. In other words, both plane and plate bending problems as well as the stretching-bending coupling problems are all explained in this book. In addition to the introduction of the theory of anisotropic elasticity, several important subjects have are discussed in this book such as interfaces, cracks, holes, inclusions, contact problems, piezoelectric materials, thermoelastic problems and boundary element a
Pérez-Nadal, Guillem
2016-01-01
We consider a non-relativistic free scalar field theory with a type of anisotropic scale invariance in which the number of coordinates "scaling like time" is generically greater than one. We propose the Cartesian product of two curved spaces, with the metric of each space parameterized by the other space, as a notion of curved background to which the theory can be extended. We study this type of geometries, and find a family of extensions of the theory to curved backgrounds in which the anisotropic scale invariance is promoted to a local, Weyl-type symmetry.
On the Newtonian anisotropic configurations
Energy Technology Data Exchange (ETDEWEB)
Shojai, F. [University of Tehran, Department of Physics, Tehran (Iran, Islamic Republic of); Institute for Research in Fundamental Sciences (IPM), Foundations of Physics Group, School of Physics, Tehran (Iran, Islamic Republic of); Fazel, M.R.; Stepanian, A. [University of Tehran, Department of Physics, Tehran (Iran, Islamic Republic of); Kohandel, M. [Alzahra University, Department of Sciences, Tehran (Iran, Islamic Republic of)
2015-06-15
In this paper we are concerned with the effects of an anisotropic pressure on the boundary conditions of the anisotropic Lane-Emden equation and the homology theorem. Some new exact solutions of this equation are derived. Then some of the theorems governing the Newtonian perfect fluid star are extended, taking the anisotropic pressure into account. (orig.)
Indian Academy of Sciences (India)
B B Bhowmik; A Rajput
2004-06-01
Anisotropic Bianchi Type-I cosmological models have been studied on the basis of Lyra's geometry. Two types of models, one with constant deceleration parameter and the other with variable deceleration parameter have been derived by considering a time-dependent displacement field.
Anisotropic Ambient Volume Shading.
Ament, Marco; Dachsbacher, Carsten
2016-01-01
We present a novel method to compute anisotropic shading for direct volume rendering to improve the perception of the orientation and shape of surface-like structures. We determine the scale-aware anisotropy of a shading point by analyzing its ambient region. We sample adjacent points with similar scalar values to perform a principal component analysis by computing the eigenvectors and eigenvalues of the covariance matrix. In particular, we estimate the tangent directions, which serve as the tangent frame for anisotropic bidirectional reflectance distribution functions. Moreover, we exploit the ratio of the eigenvalues to measure the magnitude of the anisotropy at each shading point. Altogether, this allows us to model a data-driven, smooth transition from isotropic to strongly anisotropic volume shading. In this way, the shape of volumetric features can be enhanced significantly by aligning specular highlights along the principal direction of anisotropy. Our algorithm is independent of the transfer function, which allows us to compute all shading parameters once and store them with the data set. We integrated our method in a GPU-based volume renderer, which offers interactive control of the transfer function, light source positions, and viewpoint. Our results demonstrate the benefit of anisotropic shading for visualization to achieve data-driven local illumination for improved perception compared to isotropic shading. PMID:26529745
Dynamics of Anisotropic Universes
Pérez, J
2006-01-01
We present a general study of the dynamical properties of Anisotropic Bianchi Universes in the context of Einstein General Relativity. Integrability results using Kovalevskaya exponents are reported and connected to general knowledge about Bianchi dynamics. Finally, dynamics toward singularity in Bianchi type VIII and IX universes are showed to be equivalent in some precise sence.
Fractures in anisotropic media
Shao, Siyi
Rocks may be composed of layers and contain fracture sets that cause the hydraulic, mechanical and seismic properties of a rock to be anisotropic. Coexisting fractures and layers in rock give rise to competing mechanisms of anisotropy. For example: (1) at low fracture stiffness, apparent shear-wave anisotropy induced by matrix layering can be masked or enhanced by the presence of a fracture, depending on the fracture orientation with respect to layering, and (2) compressional-wave guided modes generated by parallel fractures can also mask the presence of matrix layerings for particular fracture orientations and fracture specific stiffness. This report focuses on two anisotropic sources that are widely encountered in rock engineering: fractures (mechanical discontinuity) and matrix layering (impedance discontinuity), by investigating: (1) matrix property characterization, i.e., to determine elastic constants in anisotropic solids, (2) interface wave behavior in single-fractured anisotropic media, (3) compressional wave guided modes in parallel-fractured anisotropic media (single fracture orientation) and (4) the elastic response of orthogonal fracture networks. Elastic constants of a medium are required to understand and quantify wave propagation in anisotropic media but are affected by fractures and matrix properties. Experimental observations and analytical analysis demonstrate that behaviors of both fracture interface waves and compressional-wave guided modes for fractures in anisotropic media, are affected by fracture specific stiffness (controlled by external stresses), signal frequency and relative orientation between layerings in the matrix and fractures. A fractured layered medium exhibits: (1) fracture-dominated anisotropy when the fractures are weakly coupled; (2) isotropic behavior when fractures delay waves that are usually fast in a layered medium; and (3) matrix-dominated anisotropy when the fractures are closed and no longer delay the signal. The
Anisotropic progressive photon mapping
Liu, XiaoDan; Zheng, ChangWen
2014-01-01
Progressive photon mapping solves the memory limitation problem of traditional photon mapping. It gives the correct radiance with a large passes, but it converges slowly. We propose an anisotropic progressive photon mapping method to generate high quality images with a few passes. During the rendering process, different from standard progressive photon mapping, we store the photons on the surfaces. At the end of each pass, an anisotropic method is employed to compute the radiance of each eye ray based on the stored photons. Before move to a new pass, the photons in the scene are cleared. The experiments show that our method generates better results than the standard progressive photon mapping in both numerical and visual qualities.
Molecular anisotropic magnetoresistance
Otte, Fabian; Heinze, Stefan; Mokrousov, Yuriy
2015-01-01
Using density functional theory calculations, we demonstrate that the effect of anisotropic magnetoresistance (AMR) can be enhanced by orders of magnitude with respect to conventional bulk ferromagnets in junctions containing molecules sandwiched between ferromagnetic leads. We study ballistic transport in metal-benzene complexes contacted by $3d$ transition-metal wires. We show that the gigantic AMR can arise from spin-orbit coupling effects in the leads, drastically enhanced by orbital-symm...
Extremely Anisotropic Scintillations
Walker, Mark; Bignall, Hayley
2008-01-01
A small number of quasars exhibit interstellar scintillation on time-scales less than an hour; their scintillation patterns are all known to be anisotropic. Here we consider a totally anisotropic model in which the scintillation pattern is effectively one-dimensional. For the persistent rapid scintillators J1819+3845 and PKS1257-326 we show that this model offers a good description of the two-station time-delay measurements and the annual cycle in the scintillation time-scale. Generalising the model to finite anisotropy yields a better match to the data but the improvement is not significant and the two additional parameters which are required to describe this model are not justified by the existing data. The extreme anisotropy we infer for the scintillation patterns must be attributed to the scattering medium rather than a highly elongated source. For J1819+3845 the totally anisotropic model predicts that the particular radio flux variations seen between mid July and late August should repeat between late Au...
Experimental compaction of anisotropic granular media
Ribière, Philippe; RICHARD, Patrick; Bideau, Daniel; Delannay, Renaud
2005-01-01
We report on experiments to measure the temporal and spatial evolution of packin g arrangements of anisotropic and weakly confined granular material, using high-resolution $\\gamma$-ray adsorption. In these experiments, the particle configurations start from an initially disordered, low-packing-fraction state and under vertical solicitation s evolve to a dense state. We find that the packing fraction evolution is slowed by the grain anisotropy but, as for spherically shaped grains, can be well...
Model anisotropic quantum Hall states
Qiu, R. -Z.; Haldane, F.D.M.; Wan, Xin; Yang, Kun; Yi, Su
2012-01-01
Model quantum Hall states including Laughlin, Moore-Read and Read-Rezayi states are generalized into appropriate anisotropic form. The generalized states are exact zero-energy eigenstates of corresponding anisotropic two- or multi-body Hamiltonians, and explicitly illustrate the existence of geometric degrees of in the fractional quantum Hall effect. These generalized model quantum Hall states can provide a good description of the quantum Hall system with anisotropic interactions. Some numeri...
On the Relativistic anisotropic configurations
Shojai, F; Stepanian, A
2016-01-01
In this paper we study anisotropic spherical polytropes within the framework of general relativity. Using the anisotropic Tolman-Oppenheimer-Volkov (TOV) equations, we explore the relativistic anisotropic Lane-Emden equations. We find how the anisotropic pressure affects the boundary conditions of these equations. Also we argue that the behaviour of physical quantities near the center of star changes in the presence of anisotropy. For constant density, a class of exact solution is derived with the aid of a new ansatz and its physical properties are discussed.
Relaxation of Anisotropic Glasses
DEFF Research Database (Denmark)
Deubener, Joachim; Martin, Birgit; Wondraczek, Lothar; Yue, Yuanzheng
2004-01-01
Anisotropic glasses are obtained from uniaxial compressing and pulling of glass forming liquids above the transition temperature range. To freeze-in, at least partly the structural state of the flowing melt, cylindrical samples were subjected to a controlled cooling process under constant load...... differential scanning calorimetry (DSC) and dilatometry. The energy release and expansion-shrinkage behaviour of the glasses are investigated as a function of the applied deformation stress. Structural origins of the frozen-in birefringence induced by viscous flow are discussed and correlation between the...
Anisotropically Inflating Universes
Barrow, J D; Barrow, John D.; Hervik, Sigbjorn
2008-01-01
We show that in theories of gravity that add quadratic curvature invariants to the Einstein-Hilbert action there exist expanding vacuum cosmologies with positive cosmological constant which do not approach the de Sitter universe. Exact solutions are found which inflate anisotropically. This behaviour is driven by the Ricci curvature invariant and has no counterpart in the general relativistic limit. These examples show that the cosmic no-hair theorem does not hold in these higher-order extensions of general relativity and raises new questions about the ubiquity of inflation in the very early universe and the thermodynamics of gravitational fields.
Anisotropic Stars Exact Solutions
Dev, K; Dev, Krsna; Gleiser, Marcelo
2000-01-01
We study the effects of anisotropic pressure on the properties of spherically symmetric, gravitationally bound objects. We consider the full general relativistic treatment of this problem and obtain exact solutions for various form of equations of state connecting the radial and tangential pressures. It is shown that pressure anisotropy can have significant effects on the structure and properties of stellar objects. In particular, the maximum value of 2M/R can approach unity (2M/R < 8/9 for isotropic objects) and the surface redshift can be arbitrarily large.
Autofocus imaging: Experimental results in an anisotropic austenitic weld
Zhang, J.; Drinkwater, B. W.; Wilcox, P. D.; Hunter, A.
2012-05-01
The quality of an ultrasonic array image, especially for anisotropic material, depends on accurate information about acoustic properties. Inaccuracy of acoustic properties causes image degradation, e.g., blurring, errors in locating of reflectors and introduction of artifacts. In this paper, for an anisotropic austenitic steel weld, an autofocus imaging technique is presented. The array data from a series of beacons is captured and then used to statistically extract anisotropic weld properties by using a Monte-Carlo inversion approach. The beacon and imaging systems are realized using two separated arrays; one acts as a series of beacons and the other images these beacons. Key to the Monte-Carlo inversion scheme is a fast forward model of wave propagation in the anisotropic weld and this is based on the Dijkstra algorithm. Using this autofocus approach a measured weld map was extracted from an austenitic weld and used to reduce location errors, initially greater than 6mm, to less than 1mm.
Surface instabilities during straining of anisotropic materials
DEFF Research Database (Denmark)
Legarth, Brian Nyvang; Richelsen, Ann Bettina
2006-01-01
The development of instabilities in traction-free surfaces is investigated numerically using a unit cell model. Full finite strain analyses are conducted using isotropic as well as anisotropic yield criteria and both plane strain tension and compression are considered. In the load range of tension...... investigated, it is found that isotropic plasticity can only predict surface instabilities if non-associated plastic flow is accounted for. However, for anisotropic plasticity a surface instability is observed for associated plastic flow if the principal axes of anisotropy coincide with the directions...... of principal overall strain. For other orientations surface instabilities are seen when non-associated plastic flow is taken into account. Compared to tension, smaller compressive deformations are needed in order to initiate a surface instability....
Optics of anisotropic nanostructures
Rokushima, Katsu; Antoš, Roman; Mistrík, Jan; Višňovský, Štefan; Yamaguchi, Tomuo
2006-07-01
The analytical formalism of Rokushima and Yamakita [J. Opt. Soc. Am. 73, 901-908 (1983)] treating the Fraunhofer diffraction in planar multilayered anisotropic gratings proved to be a useful introduction to new fundamental and practical situations encountered in laterally structured periodic (both isotropic and anisotropic) multilayer media. These are employed in the spectroscopic ellipsometry for modeling surface roughness and in-depth profiles, as well as in the design of various frequency-selective elements including photonic crystals. The subject forms the basis for the solution of inverse problems in scatterometry of periodic nanostructures including magnetic and magneto-optic recording media. It has no principal limitations as for the frequencies and period to radiation wavelength ratios and may include matter wave diffraction. The aim of the paper is to make this formalism easily accessible to a broader community of students and non-specialists. Many aspects of traditional electromagnetic optics are covered as special cases from a modern and more general point of view, e.g., plane wave propagation in isotropic media, reflection and refraction at interfaces, Fabry-Perot resonator, optics of thin films and multilayers, slab dielectric waveguides, crystal optics, acousto-, electro-, and magneto-optics, diffraction gratings, etc. The formalism is illustrated on a model simulating the diffraction on a ferromagnetic wire grating.
Anisotropic spheres in general relativity
International Nuclear Information System (INIS)
A prescription originally conceived for perfect fluids is extended to the case of anisotropic pressures. The method is used to obtain exact analytical solutions of the Einstein equations for spherically symmetric selfgravitating distribution of anisotropic matter. The solutions are matched to the Schwarzschild exterior metric. (author). 15 refs
Review of anisotropic flow correlations in ultrarelativistic heavy-ion collisions
Zhou, You
2016-01-01
Anisotropic flow phenomena is a key probe of the existence of Quark-Gluon Plasma. Several new observable associated with correlations between anisotropic flow harmonics are developed, which are expected to be sensitive to the initial fluctuations and transport properties of the created matter in heavy ion collisions. I review recent developments of correlations of anisotropic flow harmonics. The experimental measurements, together with the comparisons to theoretical model calculations, open up new opportunities of exploring novel QCD dynamics in heavy-ion collisions.
Averaging anisotropic cosmologies
Barrow, J D; Barrow, John D.; Tsagas, Christos G.
2006-01-01
We examine the effects of spatial inhomogeneities on irrotational anisotropic cosmologies by looking at the average properties of pressure-free Bianchi-type models. Adopting the Buchert averaging scheme, we identify the kinematic backreaction effects by focussing on spacetimes with zero or isotropic spatial curvature. This allows us to close the system of the standard scalar formulae with a propagation equation for the shear magnitude. We find no change in the already known conditions for accelerated expansion. The backreaction terms are expressed as algebraic relations between the mean-square fluctuations of the models' irreducible kinematical variables. Based on these we investigate the early evolution of averaged vacuum Bianchi type $I$ universes and those filled with pressureless matter. In the latter case we show that the backreaction effects can modify the familiar Kasner-like singularity and potentially remove Mixmaster-type oscillations. We also discuss the possibility of accelerated expansion due to ...
Thermodynamics of anisotropic branes
Ávila, Daniel; Patiño, Leonardo; Trancanelli, Diego
2016-01-01
We study the thermodynamics of flavor D7-branes embedded in an anisotropic black brane solution of type IIB supergravity. The flavor branes undergo a phase transition between a `Minkowski embedding', in which they lie outside of the horizon, and a `black hole embedding', in which they fall into the horizon. This transition depends on two independent dimensionless ratios, which are formed out of the black hole temperature, its anisotropy parameter, and the mass of the flavor degrees of freedom. It happens either at a critical temperature or at a critical anisotropy. A general lesson we learn from this analysis is that the anisotropy, in this particular realization, induces similar effects as the temperature. In particular, increasing the anisotropy bends the branes more and more into the horizon. Moreover, we observe that the transition becomes smoother for higher anisotropies.
Anisotropic power-law k-inflation
Ohashi, Junko; Tsujikawa, Shinji
2013-01-01
It is known that power-law k-inflation can be realized for the Lagrangian $P=Xg(Y)$, where $X=-(\\partial \\phi)^2/2$ is the kinetic energy of a scalar field $\\phi$ and $g$ is an arbitrary function in terms of $Y=Xe^{\\lambda \\phi/M_{pl}}$ ($\\lambda$ is a constant and $M_{pl}$ is the reduced Planck mass). In the presence of a vector field coupled to the inflaton with an exponential coupling $f(\\phi) \\propto e^{\\mu \\phi/M_{pl}}$, we show that the models with the Lagrangian $P=Xg(Y)$ generally give rise to anisotropic inflationary solutions with $\\Sigma/H=constant$, where $\\Sigma$ is an anisotropic shear and $H$ is an isotropic expansion rate. Provided these anisotropic solutions exist in the regime where the ratio $\\Sigma/H$ is much smaller than 1, they are stable attractors irrespective of the forms of $g(Y)$. We apply our results to concrete models of k-inflation such as the generalized dilatonic ghost condensate/the DBI model and we numerically show that the solutions with different initial conditions converge...
Decorrelation of anisotropic flow along the longitudinal direction
Pang, Long-Gang; Petersen, Hannah; Qin, Guang-You; Roy, Victor; Wang, Xin-Nian
2016-04-01
The initial energy density distribution and fluctuations in the transverse direction lead to anisotropic flow of final hadrons through collective expansion in high-energy heavy-ion collisions. Fluctuations along the longitudinal direction, on the other hand, can result in decorrelation of anisotropic flow in different regions of pseudorapidity ( η . Decorrelation of the 2nd- and 3rd-order anisotropic flow with different η gaps for final charged hadrons in high-energy heavy-ion collisions is studied in an event-by-event (3+1)D ideal hydrodynamic model with fully fluctuating initial conditions from A Multi-Phase Transport (AMPT) model. The decorrelation of anisotropic flow of final hadrons with large η gaps is found to originate from the spatial decorrelation along the longitudinal direction in the AMPT initial conditions through hydrodynamic evolution. The decorrelation is found to consist of both a linear twist and random fluctuation of the event plane angles. The agreement between our results and recent CMS data in most centralities suggests that the string-like mechanism of initial parton production in AMPT model captures the initial longitudinal fluctuation that is responsible for the measured decorrelation of anisotropic flow in Pb+Pb collisions at LHC. Our predictions for Au+Au collisions at the highest RHIC energy show stronger longitudinal decorrelation, indicating larger longitudinal fluctuations at lower beam energies. Our study also calls into question some of the current experimental methods for measuring anisotropic flow and the quantitative extraction of transport coefficients through comparisons to hydrodynamic simulations that do not include longitudinal fluctuations.
Anisotropic Inflation with General Potentials
Shi, Jiaming; Qiu, Taotao
2015-01-01
Anomalies in recent observational data indicate that there might be some "anisotropic hair" generated in an inflation period. To obtain general information about the effects of this anisotropic hair to inflation models, we studied anisotropic inflation models that involve one vector and one scalar using several types of potentials. We determined the general relationship between the degree of anisotropy and the fraction of the vector and scalar fields, and concluded that the anisotropies behave independently of the potentials. We also generalized our study to the case of multi-directional anisotropies.
Wave velocities in a pre-stressed anisotropic elastic medium
Indian Academy of Sciences (India)
M D Sharma; Neetu Garg
2006-04-01
Modiﬁed Christoffel equations are derived for three-dimensional wave propagation in a general anisotropic medium under initial stress.The three roots of a cubic equation deﬁne the phase velocities of three quasi-waves in the medium.Analytical expressions are used to calculate the directional derivatives of phase velocities.These derivatives are,further,used to calculate the group velocities and ray directions of the three quasi-waves in a pre-stressed anisotropic medium.Effect of initial stress on wave propagation is observed through the deviations in phase velocity,group velocity and ray direction for each of the quasi-waves.The variations of these deviations with the phase direction are plotted for a numerical model of general anisotropic medium with triclinic/ monoclinic/orthorhombic symmetry.
Gradient expansion for anisotropic hydrodynamics
Florkowski, Wojciech; Spaliński, Michał
2016-01-01
We compute the gradient expansion for anisotropic hydrodynamics. The results are compared with the corresponding expansion of the underlying kinetic-theory model with the collision term treated in the relaxation time approximation. We find that a recent formulation of anisotropic hydrodynamics based on an anisotropic matching principle yields the first three terms of the gradient expansion in agreement with those obtained for the kinetic theory. This gives further support for this particular hydrodynamic model as a good approximation of the kinetic-theory approach. We further find that the gradient expansion of anisotropic hydrodynamics is an asymptotic series, and the singularities of the analytic continuation of its Borel transform indicate the presence of non-hydrodynamic modes.
Photon states in anisotropic media
Indian Academy of Sciences (India)
Deepak Kumar
2002-08-01
Quantum aspects of optical polarization are discussed for waves traveling in anisotropic dielectric media with a view to relate the dynamics of polarization with that of photon spin and its manipulation by classical polarizers.
Application of Anisotropic Texture Components
Eschner, Th.; Fundenberger, J.-J.
1997-01-01
The description of textures in terms of texture components is an established conception in quantitative texture analysis. Recent developments lead to the representation of orientation distribution functions as a weighted sum of model functions, each corresponding to one anisotropic texture component. As was shown previously, an adequate texture description is possible with only a very small number of anisotropic texture components. As a result, textures and texture changes can be described by...
Metal-induced apoptosis: mechanisms
International Nuclear Information System (INIS)
The past decade has seen an intense focus on mechanisms of apoptosis. Many important observations on the various signaling pathways mediating apoptotic cell death have been made and our understanding of the importance of apoptosis in both normal growth and development and pathophysiology has greatly increased. In addition, mechanisms of metal-induced toxicity continue to be of interest given the ubiquitous nature of these contaminants. The purpose of this review is to summarize our current understanding of the apoptotic pathways that are initiated by metals, mainly established (arsenic, cadmium, chromium, nickel, beryllium) and possible (lead, antimony, cobalt) human carcinogens. Increased understanding of metal-induced apoptosis is critical to illuminate mechanisms of metal-induced carcinogenesis, as well as the potential of metal species (arsenic) as chemotherapeutic agents
Gravity waves signatures from anisotropic preinflation
International Nuclear Information System (INIS)
We show that expanding or contracting Kasner universes are unstable due to the amplification of gravitational waves (GW). As an application of this general relativity effect, we consider a preinflationary anisotropic geometry characterized by a Kasner-like expansion, which is driven dynamically towards inflation by a scalar field. We investigate the evolution of linear metric fluctuations around this background, and calculate the amplification of the long-wavelength GW of a certain polarization during the anisotropic expansion (this effect is absent for another GW polarization, and for scalar fluctuations). These GW are superimposed to the usual tensor modes of quantum origin from inflation, and are potentially observable if the total number of inflationary e-folds exceeds the minimum required to homogenize the observable universe only by a small margin. Their contribution to the temperature anisotropy angular power spectrum decreases with the multipole l as l-p, where p depends on the slope of the initial GW power spectrum. Constraints on the long-wavelength GW can be translated into limits on the total duration of inflation and the initial GW amplitude. The instability of classical GW (and zero-vacuum fluctuations of gravitons) during Kasner-like expansion (or contraction) may have other interesting applications. In particular, if GW become nonlinear, they can significantly alter the geometry before the onset of inflation.
Longitudinal Decorrelation of Anisotropic Flows in Heavy-ion Collisions at the LHC
Pang, Long-Gang; Roy, Victor; Wang, Xin-Nian; Ma, Guo-Liang
2014-01-01
Fluctuations in the initial transverse energy-density distribution lead to anisotropic flows as observed in central high-energy heavy-ion collisions. Studies of longitudinal fluctuations of the anisotropic flows can shed further lights on the initial conditions and dynamical evolution of the hot quark-gluon matter in these collisions. Correlations between anisotropic flows with varying pseudo-rapidity gaps in Pb+Pb collisions at the LHC are investigated using both an event-by-event (3+1)-D ideal hydrodynamical model with fluctuating initial conditions and the AMPT Monte Carlo model for high-energy heavy-ion collisions. Anisotropic flows at different pseudo-rapidities are found to become significantly decorrelated with increasing pseudo-rapidity gaps due to longitudinal fluctuations in the initial states of heavy-ion collisions. The longitudinal correlation of the elliptic flow shows a strong centrality dependence while the correlation of the triangular flow is independent of the centrality. Longitudinal fluct...
Shear-free anisotropic cosmological models in {f (R)} gravity
Abebe, Amare; Momeni, Davood; Myrzakulov, Ratbay
2016-04-01
We study a class of shear-free, homogeneous but anisotropic cosmological models with imperfect matter sources in the context of f( R) gravity. We show that the anisotropic stresses are related to the electric part of the Weyl tensor in such a way that they balance each other. We also show that within the class of orthogonal f( R) models, small perturbations of shear are damped, and that the electric part of the Weyl tensor and the anisotropic stress tensor decay with the expansion as well as the heat flux of the curvature fluid. Specializing in locally rotationally symmetric spacetimes in orthonormal frames, we examine the late-time behaviour of the de Sitter universe in f( R) gravity. For the Starobinsky model of f( R), we study the evolutionary behavior of the Universe by numerically integrating the Friedmann equation, where the initial conditions for the expansion, acceleration and jerk parameters are taken from observational data.
Decorrelation of anisotropic flows along the longitudinal direction
Pang, Long-Gang; Qin, Guang-You; Roy, Victor; Wang, Xin-Nian
2015-01-01
The initial energy density distribution and fluctuation in the transverse direction lead to anisotropic flows of final hadrons through collective expansion in high-energy heavy-ion collisions. Fluctuations along the longitudinal direction, on the other hand, can result in decorrelation of anisotropic flows in different regions of pseudo rapidity ($\\eta$). Decorrelation of the $2$nd and $3$rd order anisotropic flows with different $\\eta$ gaps for final charged hadrons in high-energy heavy-ion collisions is studied in an event-by-event (3+1)D ideal hydrodynamic model with fully fluctuating initial conditions from A Multi-Phase Transport (AMPT) model. The decorrelation of anisotropic flows of final hadrons with large $\\eta$ gaps are found to originate from the spatial decorrelation along the longitudinal direction in the AMPT initial conditions through hydrodynamic evolution. The decorrelation is found to consist of both a linear twist and random fluctuation of the event-plane angles. The agreement between our r...
Continuum mechanics of anisotropic materials
Cowin, Stephen C
2013-01-01
Continuum Mechanics of Anisotropic Materials(CMAM) presents an entirely new and unique development of material anisotropy in the context of an appropriate selection and organization of continuum mechanics topics. These features will distinguish this continuum mechanics book from other books on this subject. Textbooks on continuum mechanics are widely employed in engineering education, however, none of them deal specifically with anisotropy in materials. For the audience of Biomedical, Chemical and Civil Engineering students, these materials will be dealt with more frequently and greater accuracy in their analysis will be desired. Continuum Mechanics of Anisotropic Materials' author has been a leader in the field of developing new approaches for the understanding of anisotropic materials.
Superlens from complementary anisotropic metamaterials
Li, G. X.; Tam, H. L.; Wang, F. Y.; Cheah, K. W.
2007-12-01
Metamaterials with isotropic property have been shown to possess novel optical properties such as a negative refractive index that can be used to design a superlens. Recently, it was shown that metamaterials with anisotropic property can translate the high-frequency wave vector k values from evanescence to propagating. However, electromagnetic waves traveling in single-layer anisotropic metamaterial produce diverging waves of different spatial frequency. In this work, it is shown that, using bilayer metamaterials that have complementary anisotropic property, the diverging waves are recombined to produce a subwavelength image, i.e., a superlens device can be designed. The simulation further shows that the design can be achieved using a metal/oxide multilayer, and a resolution of 30 nm can be easily obtained in the optical frequency range.
Latest developments in anisotropic hydrodynamics
Tinti, Leonardo
2015-01-01
We discuss the leading order of anisotropic hydrodynamics expansion. It has already been shown that in the (0+1) and (1+1)-dimensional cases it is consistent with the second order viscous hydrodynamics, and it provides a striking agreement with the exact solutions of the Boltzmann equation. Quite recently, a new set of equations has been proposed for the leading order of anisotropic hydrodynamics, which is consistent with the second order viscous hydrodynamics in the most general (3+1)-dimensional case, and does not require a next-to-leading treatment for describing pressure anisotropies in the transverse plane.
Anisotropic hydrodynamics: Motivation and methodology
International Nuclear Information System (INIS)
In this proceedings contribution I review recent progress in our understanding of the bulk dynamics of relativistic systems that possess potentially large local rest frame momentum-space anisotropies. In order to deal with these momentum-space anisotropies, a reorganization of relativistic viscous hydrodynamics can be made around an anisotropic background, and the resulting dynamical framework has been dubbed “anisotropic hydrodynamics”. I also discuss expectations for the degree of momentum-space anisotropy of the quark–gluon plasma generated in relativistic heavy ion collisions at RHIC and LHC from second-order viscous hydrodynamics, strong-coupling approaches, and weak-coupling approaches
Retinskaya, Ekaterina
2014-01-01
Ultra-Relativistic heavy-ion physics is a promising field of high energy physics connecting two fields: nuclear physics and elementary particle physics. Experimental achievements of the last years have provided an opportunity to study the properties of a new state of matter created in heavy-ion collisions called quark-gluon plasma. The initial state of two colliding nuclei is affected by fluctuations coming from wave- functions of nucleons. These fluctuations lead to the momentum anisotropy o...
Quantum electrodynamics of inhomogeneous anisotropic media
Energy Technology Data Exchange (ETDEWEB)
Lopez, Adrian E.R.; Lombardo, Fernando C. [Ciudad Universitaria, Departamento de Fisica Juan Jose Giambiagi, Buenos Aires (Argentina); IFIBA CONICET-UBA, Facultad de Ciencias Exactas y Naturales, Buenos Aires (Argentina)
2015-02-01
In this work we calculate the closed time path generating functional for the electromagnetic (EM) field interacting with inhomogeneous anisotropic matter. For this purpose, we first find a general expression for the electromagnetic field's influence action from the interaction of the field with a composite environment consisting in the quantum polarization degrees of freedom in each point of space, at arbitrary temperatures, connected to thermal baths. Then we evaluate the generating functional for the gauge field, in the temporal gauge, by implementing the Faddeev-Popov procedure. Finally, through the point-splitting technique, we calculate closed expressions for the energy, the Poynting vector, and the Maxwell tensor in terms of the Hadamard propagator. We show that all the quantities have contributions from the field's initial conditions and also from the matter degrees of freedom. Throughout the whole work we discuss how the gauge invariance must be treated in the formalism when the EM-field is interacting with inhomogeneous anisotropic matter. We study the electrodynamics in the temporal gauge, obtaining the EM-field's equation and a residual condition. Finally we analyze the case of the EM-field in bulk material and also discuss several general implications of our results in relation with the Casimir physics in a non-equilibrium scenario. (orig.)
Failure in imperfect anisotropic materials
DEFF Research Database (Denmark)
Legarth, Brian Nyvang
2005-01-01
The fundamental cause of crack growth, namely nucleation and growth of voids, is investigated numerically for a two phase imperfect anisotropic material. A unit cell approach is adopted from which the overall stress strain is evaluated. Failure is observed as a sudden stress drop and depending on...
Magnetic relaxation in anisotropic magnets
DEFF Research Database (Denmark)
Lindgård, Per-Anker
1971-01-01
The line shape and the kinematic and thermodynamic slowing down of the critical and paramagnetic relaxation in axially anisotropic materials are discussed. Kinematic slowing down occurs only in the longitudinal relaxation function. The thermodynamic slowing down occurs in either the transverse or...
Sphingosine in apoptosis signaling.
Cuvillier, Olivier
2002-12-30
The sphingolipid metabolites ceramide, sphingosine, and sphingosine 1-phosphate contribute to controlling cell proliferation and apoptosis. Ceramide and its catabolite sphingosine act as negative regulators of cell proliferation and promote apoptosis. Conversely, sphingosine 1-phosphate, formed by phosphorylation of sphingosine by a sphingosine kinase, has been involved in stimulating cell growth and inhibiting apoptosis. As the phosphorylation of sphingosine diminishes apoptosis, while dephosphorylation of sphingosine 1-phosphate potentiates it, the role of sphingosine as a messenger of apoptosis is of importance. Herein, the effects of sphingosine on diverse signaling pathways implicated in the apoptotic process are reviewed. PMID:12531549
Observable effects of anisotropic bubble nucleation
Blanco-Pillado, Jose J
2010-01-01
Our universe may have formed via bubble nucleation in an eternally-inflating background. Furthermore, the background may have a compact dimension--the modulus of which tunnels out of a metastable minimum during bubble nucleation--which subsequently grows to become one of our three large spatial dimensions. Then the reduced symmetry of the background is equivalent to anisotropic initial conditions in our bubble universe. We compute the inflationary spectrum in such a scenario and, as a first step toward understanding the effects of anisotropy, project it onto spherical harmonics. The resulting spectrum exhibits anomalous multipole correlations, their relative amplitude set by the present curvature parameter, which extend to arbitrarily large multipole moments. This raises the possibility of future detection, if slow-roll inflation does not last too long within our bubble. A full understanding of the observational signal must account for the effects of background anisotropy on photon free streaming, and is left...
Conductivities in an anisotropic medium
Khimphun, Sunly; Park, Chanyong
2016-01-01
In order to imitate anisotropic medium of a condensed matter system, we take into account an Einstein-Maxwell-dilaton-axion model as a dual gravity theory where the anisotropy is caused by different momentum relaxations. This gravity model allows an anisotropic charged black hole solution. On this background, we investigate how the linear responses of vector modes like electric, thermoelectric, and thermal conductivities rely on the anisotropy. We find that the electric conductivity in low frequency limit shows a Drude peak and that in the intermediate frequency regime it reveals the power law behavior. Especially, when the anisotropy increases the exponent of the power law becomes smaller. In addition, we find that there exist a critical value for the anisotropy at which the DC conductivity reaches to its maximum value.
Anisotropic Inflation and Cosmological Observations
Emami, Razieh
2015-01-01
Recent observations opened up a new window on the inflationary model building. As it was firstly reported by the WMAP data, there may be some indications of statistical anisotropy on the CMB map, although the statistical significance of these findings are under debate. Motivated by these observations, people begun considering new inflationary models which may lead to statistical anisotropy. The simplest possible way to construct anisotropic inflation is to introduce vector fields. During the course of this thesis, we study models of anisotropic inflation and their observational implications such as power spectrum, bispectrum etc. Firstly we build a new model, which contains the gauge field which breaks the conformal invariance while preserving the gauge invariance. We show that in these kind of models, there can be an attractor phase in the evolution of the system when the back-reaction of the gauge field becomes important in the evolution of the inflaton field. We then study the cosmological perturbation the...
Stealths on Anisotropic Holographic Backgrounds
Ayón-Beato, Eloy; Juárez-Aubry, María Montserrat
2015-01-01
In this paper, we are interested in exploring the existence of stealth configurations on anisotropic backgrounds playing a prominent role in the non-relativistic version of the gauge/gravity correspondence. By stealth configuration, we mean a nontrivial scalar field nonminimally coupled to gravity whose energy-momentum tensor evaluated on the anisotropic background vanishes identically. In the case of a Lifshitz spacetime with a nontrivial dynamical exponent z, we spotlight the role played by the anisotropy to establish the holographic character of the stealth configurations, i.e. the scalar field is shown to only depend on the radial holographic direction. This configuration which turns out to be massless and without integration constants is possible for a unique value of the nonminimal coupling parameter. Then, using a simple conformal argument, we map this configuration into a stealth solution defined on the so-called hyperscaling violation metric which is conformally related to the Lifshitz spacetime. Thi...
Evolution of cosmological event horizons in anisotropic universes
Kim, Hyeong-Chan
2012-01-01
We study the evolution of cosmological event horizons in anisotropic Kasner universes in the presence of a positive cosmological constant by analyzing null geodesics. At later times, the asymptotic form of cosmological horizons is the same spherical surface as the de Sitter horizon. At the early times, however, it has non-spherical shape with its eccentricity decreases with time. The horizon area increases with time respecting the second law of thermodynamics. The initial shape of the cosmological horizon takes the form of a needle or pancake surface depending on the nature of the background spacetimes. We also briefly discuss that the presence of the holographic dark energy will modify significantly the initial evolution of the anisotropic universes.
Mirage technique in anisotropic solids
Quelin, X.; Perrin, B; Perrin, Bernard; Louis, G.
1994-01-01
Theoretical and experimental analysis of heat diffusion in an anisotropic medium are presented. The solution of the 3D thermal conduction equation in an orthorhombic medium is calculated by the mean of a Fourier transforms method. Experiments were performed on an orthorhombic polydiacetylene single crystal sample. The temperature field at the sample surface was determined using the photothermal probe beam deflection technique. Then the 3 coefficients of the thermal conductivity tensor have be...
A new model for spherically symmetric anisotropic compact star
Maurya, S K; Dayanandan, Baiju; Ray, Saibal
2016-01-01
In this article we obtain a new anisotropic solution for Einstein's field equation of embedding class one metric. The solution is representing the realistic objects such as $Her~X-1$ and $RXJ~1856-37$. We perform detailed investigation of both objects by solving numerically the Einstein field equations under with anisotropic pressure. The physical features of the parameters depend on the anisotropic factor i.e. if anisotropy is zero everywhere inside the star then the density and pressures will become zero and metric turns out to be flat. We report our results and compare with the above mentioned two compact objects on a number of key aspects: the central density, the surface density onset and the critical scaling behavior, the effective mass and radius ratio, the anisotropization with isotropic initial conditions, adiabatic index and red shift. Along with this we have also made a comparison between the classical limit and theoretical model treatment of the compact objects. Finally we discuss the implications...
A new model for spherically symmetric anisotropic compact star
Maurya, S. K.; Gupta, Y. K.; Dayanandan, Baiju; Ray, Saibal
2016-05-01
In this article we obtain a new anisotropic solution for Einstein's field equations of embedding class one metric. The solution represents realistic objects such as Her X-1 and RXJ 1856-37. We perform a detailed investigation of both objects by solving numerically the Einstein field equations with anisotropic pressure. The physical features of the parameters depend on the anisotropic factor i.e. if the anisotropy is zero everywhere inside the star then the density and pressures will become zero and the metric turns out to be flat. We report our results and compare with the above mentioned two compact objects as regards a number of key aspects: the central density, the surface density onset and the critical scaling behaviour, the effective mass and radius ratio, the anisotropization with isotropic initial conditions, adiabatic index and red shift. Along with this we have also made a comparison between the classical limit and theoretical model treatment of the compact objects. Finally we discuss the implications of our findings for the stability condition in a relativistic compact star.
Derivation of anisotropic dissipative fluid dynamics from the Boltzmann equation
Molnar, E.; Niemi, H.; Rischke, D. H.
2016-01-01
Fluid-dynamical equations of motion can be derived from the Boltzmann equation in terms of an expansion around a single-particle distribution function which is in local thermodynamical equilibrium, i.e., isotropic in momentum space in the rest frame of a fluid element. However, in situations where the single-particle distribution function is highly anisotropic in momentum space, such as the initial stage of heavy-ion collisions at relativistic energies, such an expansion is bound to break dow...
Numerical modelling of tunnel construction in anisotropic foliated soft rock
Markovič, Jernej
2009-01-01
The present work focuses on the influence on tunnelling in the anisotropic foliated soft rock. The excavation initiates stress redistribution around an opening and thus causes the deformation to occur. The numerical problem of the tunnel excavation was modelled in the Plaxis 2D code using different soil constitutive models for modelling the rock mass behaviour. A parametric study was performed to obtain the model response to alteration of the rock mass parameters. The analysis was divided int...
Scalar particle creation in an anisotropic universe
International Nuclear Information System (INIS)
The problem of quantized scalar field creation in an anisotropic spatially homogeneous background universe is reexamined from a Schroedinger-picture point of view. For each mode a complete set of orthonormal wave functions, psi/subN/, is obtained using the method of Salusti and Zirilli. These wave functions are valid at all times even if there is an initial cosmological singularity and depend only on the solution of the classical equation of motion. The wave functions are fixed completely by requiring the classical solution to have positive-frequency WKB form when the universe reaches the stage of adiabatic expansion. These wave functions are eigenfunctions of a conserved number operator which has the usual particle interpretation in the adiabatic regime. An intitial state near the singularity is chosen as a superposition of the wave functions, psi/subN/, and the particle number in the adiabatic regime is calculated. For plane-wave initial states, which follow the classical behavior near the singularity, the final particle number depends only on the parameters of the initial wave packet. For an initial state which instantaneously diagonalizes the Hamiltonian, an (arbitrary) initial time must be chosen. If the mode in question is in the adiabatic regime at that time almost no particle creation occurs. If it is not adiabatic, creation occurs and becomes infinite if the initial time is taken to be that of the singularity. This creation is a consequence of the failure of particle number to be well defined in this regime. Comparisons with other particle-creation studies are made
Apoptosis of human intestinal epithelial cells after bacterial invasion.
Kim, J. M.; Eckmann, L; Savidge, T. C.; Lowe, D C; Witthöft, T; Kagnoff, M F
1998-01-01
Epithelial cells that line the human intestinal mucosa are the initial site of host invasion by bacterial pathogens. The studies herein define apoptosis as a new category of intestinal epithelial cell response to bacterial infection. Human colon epithelial cells are shown to undergo apoptosis following infection with invasive enteric pathogens, such as Salmonella or enteroinvasive Escherichia coli. In contrast to the rapid onset of apoptosis seen after bacterial infection of mouse monocyte-ma...
Crisanti, Patricia; Lecain, Eric; Omri, Boubaker
2007-01-01
Retinal degenerations are a common cause of blindness in Western countries. Despite various origins of retinal degeneration it is well recognised that. Apoptosis is the final pathway of photoreceptor neuron cell death in these diseases. So that Ivana Scovassi presents the historical development of our knowledge in: apoptosis, its difference with other forms of cell death as necrosis and analyses when and how apoptosis arises, discussing also the molecular markers in this form of cell death. T...
Cytochrome c and insect cell apoptosis
Institute of Scientific and Technical Information of China (English)
Kai-Yu Liu; Hong Yang; Jian-Xin Peng; Hua-Zhu Hong
2012-01-01
The role ofcytochrome c in insect cell apoptosis has drawn considerable attention and has been subject to considerable controversy.In Drosophila,the majority of studies have demonstrated that cytochrome c may not be involved in apoptosis,although there are conflicting reports.Cytochrome c is not released from mitochondria into the cytosol and activation of the initiator caspase Dronc or effector caspase Drice is not associated with cytochrome c during apoptosis in Drosophila SL2 cells or BG2 cells.Cytochrome c failed to induce caspase activation and promote caspase activation in Drosophila cell lysates,but remarkably caused caspase activation in extracts from human cells.Knockdown of cytochrome c does not protect cells from apoptosis and over-expression of cytochrome c also does not promote apoptosis.Structural analysis has revealed that cytochrome c is not required for Dapaf-1 complex assembly.In Lepidoptera,the involvement of cytochrome c in apoptosis has been demonstrated by the accumulating evidence.Cytochrome c release from mitochondria into cytosol has been observed in different cell lines such as Spodoptera frugiperda Sf9,Spodoptera litura S1-1 and Lymantria dispar LdFB.Silencing of cytochrome c expression significantly affected apoptosis and activation of caspase and the addition of cytochrome c to cell-free extracts results in caspase activation,suggesting the activation of caspase is dependent on cytochrome c.Although Apaf- 1 has not been identified in Lepidoptera,the inhibitor of apoptosome formation can inhibit apoptosis and caspase activation.Cytochrome c may be exclusively required for Lepidoptera apoptosis.
Multidisciplinary approach to cylindrical anisotropic metamaterials
Carbonell Olivares, Jorge; Torrent Martí, Daniel; Diaz Rubio, Ana; Sánchez-Dehesa Moreno-Cid, José
2011-01-01
Anisotropic characteristics of cylindrically corrugated microstructures are analyzed in terms of their acoustic and electromagnetic (EM) behavior paying special attention to their differences and similarities. A simple analytical model has been developed using effective medium theory to understand the anisotropic features of both types of waves in terms of radial and angular components of the wave propagation velocity. The anisotropic constituent parameters have been obtained by measuring the...
New charged anisotropic compact models
Kileba Matondo, D.; Maharaj, S. D.
2016-07-01
We find new exact solutions to the Einstein-Maxwell field equations which are relevant in the description of highly compact stellar objects. The relativistic star is charged and anisotropic with a quark equation of state. Exact solutions of the field equations are found in terms of elementary functions. It is interesting to note that we regain earlier quark models with uncharged and charged matter distributions. A physical analysis indicates that the matter distributions are well behaved and regular throughout the stellar structure. A range of stellar masses are generated for particular parameter values in the electric field. In particular the observed mass for a binary pulsar is regained.
Model for Anisotropic Directed Percolation
Nguyen, V. Lien; Canessa, Enrique
1997-01-01
We propose a simulation model to study the properties of directed percolation in two-dimensional (2D) anisotropic random media. The degree of anisotropy in the model is given by the ratio $\\mu$ between the axes of a semi-ellipse enclosing the bonds that promote percolation in one direction. At percolation, this simple model shows that the average number of bonds per site in 2D is an invariant equal to 2.8 independently of $\\mu$. This result suggests that Sinai's theorem proposed originally fo...
Anisotropic spectra of acoustic turbulence
International Nuclear Information System (INIS)
We found universal anizopropic spectra of acoustic turbulence with the linear dispersion law ω(k)=ck within the framework of generalized kinetic equation which takes into account the finite time of three-wave interactions. This anisotropic spectra can assume both scale-invariant and non-scale-invariant form. The implications for the evolution of the acoustic turbulence with nonisotropic pumping are discussed. The main result of the article is that the spectra of acoustic turbulence tend to become more isotropic. (c) 2000 The American Physical Society
Anisotropic and nonlinear optical waveguides
Someda, CG
1992-01-01
Dielectric optical waveguides have been investigated for more than two decades. In the last ten years they have had the unique position of being simultaneously the backbone of a very practical and fully developed technology, as well as an extremely exciting area of basic, forefront research. Existing waveguides can be divided into two sets: one consisting of waveguides which are already in practical use, and the second of those which are still at the laboratory stage of their evolution. This book is divided into two separate parts: the first dealing with anisotropic waveguides, an
BRDF Interpolation using Anisotropic Stencils
Czech Academy of Sciences Publication Activity Database
Vávra, Radomír; Filip, Jiří
Springfield: Society for Imaging Science and Technology , 2016 - (Imai, F.; Ortiz Segovia, M.; Urban, P.), MMRMA-356.1-MMRMA-356.6 ISSN 2470-1173. [IS&T International Symposium on Electronic Imaging 2016, Measuring, Modeling, and Reproducing Material Appearance 2016. San Francisco (US), 14.2.2016-18.2.2016] R&D Projects: GA ČR(CZ) GA14-02652S Institutional support: RVO:67985556 Keywords : BRDF * stencil * anisotropic * interpolation Subject RIV: BD - Theory of Information http://library.utia.cas.cz/separaty/2016/RO/vavra-0457068.pdf
Anisotropic hydrodynamics and the early-thermalization puzzle
Florkowski, Wojciech
2012-01-01
The framework of anisotropic hydrodynamics is used in 3+1 dimensions to analyze behavior of matter produced in ultra-relativistic heavy-ion collisions. The model predictions for the hadronic transverse-momentum spectra, directed and elliptic flows, and the HBT radii are presented. We show that the effects of the initial anisotropy of pressure may be compensated by appropriate adjustment of the initial energy density. In this way, the final hadronic observables become insensitive to the early stage dynamics and the early thermalization puzzle may be circumvented.
Epithelial Cell Apoptosis and Lung Remodeling
Institute of Scientific and Technical Information of China (English)
Kazuyoshi Kuwano
2007-01-01
Lung epithelium is the primary site of lung damage in various lung diseases. Epithelial cell apoptosis has been considered to be initial event in various lung diseases. Apoptosis signaling is classically composed of two principle pathways. One is a direct pathway from death receptor ligation to caspase cascade activation and cell death. The other pathway triggered by stresses such as drugs, radiation, infectious agents and reactive oxygen species is mediated by mitochondria. Endoplasmic reticulum has also been shown to be the organelle to mediate apoptosis.Epithelial cell death is followed by remodeling processes, which consist of epithelial and fibroblast activation,cytokine production, activation of coagulation pathway, neoangiogenesis, re-epithelialization and fibrosis.Epithelial and mesenchymal interaction plays important roles in these processes. Further understanding of apoptosis signaling and its regulation by novel strategies may lead to effective treatments against various lung diseases. We review the recent advances in the understanding of apoptosis signaling and discuss the involvement of apoptosis in lung remodeling.
International Nuclear Information System (INIS)
Many structural components, such as rolled sheets, directionally solidified superalloys and composites are made of anisotropic materials. The knowledge of limit load is useful in the design and the sizing of these components and structures. This paper presents the extension of the modified mα - method to anisotropic materials. Mura's variational principle is employed in conjunction with repeated elastic finite element analyses (FEA). The secant modulus of the discretized finite elements in the reference direction components. The modified initial elastic properties are adopted to ensure the 'elastic' stress fields satisfy the anisotropic yield surface. Using the notion of 'leap-frogging to limit state,' improved lower-bound limit loads can be obtained. The formulation is applied to two anisotropic components, and the limit load estimates are compared with those using elastic compensation method and inelastic FEA. (author)
Electromagnetism on anisotropic fractal media
Ostoja-Starzewski, Martin
2013-04-01
Basic equations of electromagnetic fields in anisotropic fractal media are obtained using a dimensional regularization approach. First, a formulation based on product measures is shown to satisfy the four basic identities of the vector calculus. This allows a generalization of the Green-Gauss and Stokes theorems as well as the charge conservation equation on anisotropic fractals. Then, pursuing the conceptual approach, we derive the Faraday and Ampère laws for such fractal media, which, along with two auxiliary null-divergence conditions, effectively give the modified Maxwell equations. Proceeding on a separate track, we employ a variational principle for electromagnetic fields, appropriately adapted to fractal media, so as to independently derive the same forms of these two laws. It is next found that the parabolic (for a conducting medium) and the hyperbolic (for a dielectric medium) equations involve modified gradient operators, while the Poynting vector has the same form as in the non-fractal case. Finally, Maxwell's electromagnetic stress tensor is reformulated for fractal systems. In all the cases, the derived equations for fractal media depend explicitly on fractal dimensions in three different directions and reduce to conventional forms for continuous media with Euclidean geometries upon setting these each of dimensions equal to unity.
Inhibitor of apoptosis proteins and apoptosis
Institute of Scientific and Technical Information of China (English)
Yunbo Wei; Tingjun Fan; Miaomiao Yu
2008-01-01
Apoptosis is a physiological cell death process that plays a critical role in development, homeostasis, and immune defense of multicellular animals. Inhibitor of apoptosis proteins (IAPs) constitute a family of proteins that possess between one and three baculovirus IAP repeats. Some of them also have a really interesting new gene finger domain, and can prevent cell death by binding and inhibiting active caspases, but are regulated by IAP antagonists. Some evidence also indicates that IAP can modulate the cell cycle and signal transduction. The three main factors, IAPs, IAP antagonists, and caspases, are involved in regulating the progress of apoptosis in many species. Many studies and assumptions have been focused on the anfractuous interactions between these three main factors to explore their real functional model in order to develop potential anticancer drugs.In this review, we describe the classification, molecular structures, and properties of IAPs and discuss the mechanisms of apoptosis. We also discuss the promising significance of clinical applications of IAPs in the diagnosis and treatment of malignancy.
Apoptosis signaling pathways and lymphocyte homeostasis
Institute of Scientific and Technical Information of China (English)
Guangwu Xu; Yufang Shi
2007-01-01
It has been almost three decades since the term "apoptosis" was first coined to describe a unique form of cell death that involves orderly, gene-dependent cell disintegration. It is now well accepted that apoptosis is an essential life process for metazoan animals and is critical for the formation and function of tissues and organs. In the adult mammalian body, apoptosis is especially important for proper functioning of the immune system. In recent years, along with the rapid advancement of molecular and cellular biology, great progress has been made in understanding the mechanisms leading to apoptosis. It is generally accepted that there are two major pathways of apoptotic cell death induction: extrinsic signaling through death receptors that leads to the formation of the death-inducing signaling complex (DISC), and intrinsic signaling mainly through mitochondria which leads to the formation of the apoptosome. Formation of the DISC or apoptosome, respectively, activates initiator and common effector caspases that execute the apoptosis process. In the immune system, both pathways operate; however, it is not known whether they are sufficient to maintain lymphocyte homeostasis. Recently, new apoptotic mechanisms including caspase-independent pathways and granzyme-initiated pathways have been shown to exist in lymphocytes. This review will summarize our understanding of the mechanisms that control the homeostasis of various lymphocyte populations.
ANISOTROPIC POLARIZATION TENSORS FOR ELLIPSES AND ELLIPSOIDS
Institute of Scientific and Technical Information of China (English)
Hyeonbae Kang; Kyoungsun Kim
2007-01-01
In this paper we present a systematic way of computing the polarization tensors,anisotropic as well as isotropic, based on the boundary integral method. We then use this method to compute the anisotropic polarization tensor for ellipses and ellipsoids. The computation reveals the pair of anisotropy and ellipses which produce the same polarization tensors.
Anisotropic weak Hardy spaces and interpolation theorems
Institute of Scientific and Technical Information of China (English)
2008-01-01
In this paper, the authors establish the anisotropic weak Hardy spaces associated with very general discrete groups of dilations. Moreover, the atomic decomposition theorem of the anisotropic weak Hardy spaces is also given. As some applications of the above results, the authors prove some interpolation theorems and obtain the boundedness of the singular integral operators on these Hardy spaces.
Characterization of anisotropic acoustic metamaterial slabs
Park, Jun Hyeong; Lee, Hyung Jin; Kim, Yoon Young
2016-01-01
In an anisotropic acoustic metamaterial, the off-diagonal components of its effective mass density tensor should be considered in order to describe the anisotropic behavior produced by arbitrarily shaped inclusions. However, few studies have been carried out to characterize anisotropic acoustic metamaterials. In this paper, we propose a method that uses the non-diagonal effective mass density tensor to determine the behavior of anisotropic acoustic metamaterials. Our method accurately evaluates the effective properties of anisotropic acoustic metamaterials by separately dealing with slabs made of single and multiple unit cells along the thickness direction. To determine the effective properties, the reflection and transmission coefficients of an acoustic metamaterial slab are calculated, and then the wave vectors inside of the slab are determined using these coefficients. The effective material properties are finally determined by utilizing the spatial dispersion relation of the anisotropic acoustic metamaterial. Since the dispersion relation of an anisotropic acoustic metamaterial is explicitly used, its effective properties can be easily determined by only using a limited number of normal and oblique plane wave incidences into a metamaterial slab, unlike existing approaches requiring a large number of wave incidences. The validity of the proposed method is verified by conducting wave simulations for anisotropic acoustic metamaterial slabs with Z-shaped elastic inclusions of tilted principal material axes.
Multidisciplinary approach to cylindrical anisotropic metamaterials
International Nuclear Information System (INIS)
Anisotropic characteristics of cylindrically corrugated microstructures are analyzed in terms of their acoustic and electromagnetic (EM) behavior paying special attention to their differences and similarities. A simple analytical model has been developed using effective medium theory to understand the anisotropic features of both types of waves in terms of radial and angular components of the wave propagation velocity. The anisotropic constituent parameters have been obtained by measuring the resonances of cylindrical cavities, as well as from numerical simulations. This permits one to characterize propagation of acoustic and EM waves and to compare the fundamental anisotropic features generated by the corrugated effective medium. Anisotropic coefficients match closely in both physics fields but other relevant parameters show significant differences in the behavior of both types of waves. (paper)
Efficient Wavefield Extrapolation In Anisotropic Media
Alkhalifah, Tariq
2014-07-03
Various examples are provided for wavefield extrapolation in anisotropic media. In one example, among others, a method includes determining an effective isotropic velocity model and extrapolating an equivalent propagation of an anisotropic, poroelastic or viscoelastic wavefield. The effective isotropic velocity model can be based upon a kinematic geometrical representation of an anisotropic, poroelastic or viscoelastic wavefield. Extrapolating the equivalent propagation can use isotopic, acoustic or elastic operators based upon the determined effective isotropic velocity model. In another example, non-transitory computer readable medium stores an application that, when executed by processing circuitry, causes the processing circuitry to determine the effective isotropic velocity model and extrapolate the equivalent propagation of an anisotropic, poroelastic or viscoelastic wavefield. In another example, a system includes processing circuitry and an application configured to cause the system to determine the effective isotropic velocity model and extrapolate the equivalent propagation of an anisotropic, poroelastic or viscoelastic wavefield.
Designing Anisotropic Inflation with Form Fields
Ito, Asuka
2015-01-01
We study inflation with anisotropic hair induced by form fields. In four dimensions, the relevant form fields are gauge (one-form) fields and two-form fields. Assuming the exponential form of potential and gauge kinetic functions, we find new exact power-law solutions endowed with anisotropic hair. We also explore the phase space of anisotropic inflation and find fixed points corresponding to the exact power-law solutions. Moreover, we perform the stability analysis around the fixed points to reveal the structure of the phase space. It turns out that one of the fixed points becomes an attractor and others (if any) are saddle points. In particular, the one corresponding to anisotropic inflation becomes an attractor when it exists. We also argue that various anisotropic inflation models can be designed by choosing coupling constants.
Designing anisotropic inflation with form fields
Ito, Asuka; Soda, Jiro
2015-12-01
We study inflation with anisotropic hair induced by form fields. In four dimensions, the relevant form fields are gauge (one-form) fields and two-form fields. Assuming the exponential form of potential and gauge kinetic functions, we find new exact power-law solutions endowed with anisotropic hair. We also explore the phase space of anisotropic inflation and find fixed points corresponding to the exact power-law solutions. Moreover, we perform the stability analysis around the fixed points to reveal the structure of the phase space. It turns out that one of the fixed points becomes an attractor and others (if any) are saddle points. In particular, the one corresponding to anisotropic inflation becomes an attractor when it exists. We also argue that various anisotropic inflation models can be designed by choosing coupling constants.
Energy Technology Data Exchange (ETDEWEB)
Koudrine, A.V. [Orenburg State Medical Academy, Orenburg (Russian Federation)
1998-07-01
It is known that apoptosis is considered to be responsible for selective deletion of cells during embryogenesis, the homeostasis of cell populations in continuously renewing tissues (i.e., serving as a counterbalance to mitosis), and tissue involution in response to chemical or physical stimuli. There are many publications on these questions. On the other hand, the intracellular processes that contribute to apoptosis are incompletely understood. Therefore, the role of apoptosis in the intracellular accumulation and outflow of minerals is of considerable importance in light of both their essential functions and toxic effects. (orig.)
DNA fragmentation in apoptosis
Institute of Scientific and Technical Information of China (English)
无
2000-01-01
Cleavage of chromosomal DNA into oligonucleosomal size fragments is an integral part of apoptosis. Elegant biochemical work identified the DNA fragmentation factor (DFF) as a major apoptotic endonuclease for DNA fragmentation in vitro. Genetic studies in mice support the importance of DFF in DNA fragmentation and possibly in apoptosis in vivo. Recent work also suggests the existence of additional endonucleases for DNA degradation. Understanding the roles of individual endonucleases in apoptosis, and how they might coordinate to degrade DNA in different tissues during normal development and homeostasis, as well as in various diseased states, will be a major research focus in the near future.
Warm anisotropic inflationary universe model
Energy Technology Data Exchange (ETDEWEB)
Sharif, M.; Saleem, Rabia [University of the Punjab, Department of Mathematics, Lahore (Pakistan)
2014-02-15
This paper is devoted to the study of warm inflation using vector fields in the background of a locally rotationally symmetric Bianchi type I model of the universe. We formulate the field equations, and slow-roll and perturbation parameters (scalar and tensor power spectra as well as their spectral indices) in the slow-roll approximation. We evaluate all these parameters in terms of the directional Hubble parameter during the intermediate and logamediate inflationary regimes by taking the dissipation factor as a function of the scalar field as well as a constant. In each case, we calculate the observational parameter of interest, i.e., the tensor-scalar ratio in terms of the inflaton. The graphical behavior of these parameters shows that the anisotropic model is also compatible with WMAP7 and the Planck observational data. (orig.)
Warm Anisotropic Inflationary Universe Model
Sharif, M
2014-01-01
This paper is devoted to study the warm inflation using vector fields in the background of locally rotationally symmetric Bianchi type I universe model. We formulate the field equations, slow-roll and perturbation parameters (scalar and tensor power spectra as well as their spectral indices) under slow-roll approximation. We evaluate all these parameters in terms of directional Hubble parameter during intermediate and logamediate inflationary regimes by taking the dissipation factor as a function of scalar field as well as a constant. In each case, we calculate the observational parameter of interest, i.e., tensor-scalar ratio in terms of inflation. The graphical behavior of these parameters shows that the anisotropic model is also compatible with WMAP7 and Planck observational data.
Yagi, Kent
2015-01-01
Certain physical quantities that characterize neutron stars and quark stars (e.g. their mass, spin angular momentum and quadrupole moment) are interrelated in a way that is approximately insensitive to their internal structure. Such approximately universal relations are useful to break degeneracies in data analysis for future radio, X-ray and gravitational wave observations. Although the pressure inside compact stars is most likely nearly isotropic, certain scenarios have been put forth that suggest otherwise, for example due to phase transitions. We here investigate whether pressure anisotropy affects the approximate universal relations and whether it prevents their use in future observations. We achieve this by numerically constructing slowly-rotating and tidally-deformed, anisotropic, compact stars in General Relativity to third order in spin. We find that anisotropy affects the universal relations only weakly; the relations become less universal by a factor of 1.5-3 relative to the isotropic case, but rem...
Gravitational Baryogenesis after Anisotropic Inflation
Fukushima, Mitsuhiro; Maeda, Kei-ichi
2016-01-01
The gravitational baryogensis may not generate a sufficient baryon asymmetry in the standard thermal history of the Universe when we take into account the gravitino problem. Hence it has been suggested that anisotropy of the Universe can enhance the generation of the baryon asymmetry through the increase of the time change of the Ricci scalar curvature. We study the gravitational baryogenesis in the presence of anisotropy, which is produced at the end of an anisotropic inflation. Although we confirm that the generated baryon asymmetry is enhanced compared with the original isotropic cosmological model, taking into account the constraint on the anisotropy by the recent CMB observations, we find that it is still difficult to obtain the observed baryon asymmetry only through the gravitational baryogenesis without suffering from the gravitino problem.
Anisotropic invariance in minisuperspace models
Chagoya, Javier; Sabido, Miguel
2016-06-01
In this paper we introduce invariance under anisotropic transformations to cosmology. This invariance is one of the key ingredients of the theory of quantum gravity at a Lifshitz point put forward by Hořava. We find that this new symmetry in the minisuperspace introduces characteristics to the model that can be relevant in the ultraviolet regime. For example, by canonical quantization we find a Schrödinger-type equation which avoids the problem of frozen time in quantum cosmology. For simple cases we obtain solutions to this quantum equation in a Kantowski–Sachs (KS) minisuperspace. At the classical level, we study KS and Friedmann–Robertson–Walker cosmologies, obtaining modifications to the solutions of general relativity that can be relevant in the early Universe.
Subsurface Stress Fields in FCC Single Crystal Anisotropic Contacts
Arakere, Nagaraj K.; Knudsen, Erik; Swanson, Gregory R.; Duke, Gregory; Ham-Battista, Gilda
2004-01-01
Single crystal superalloy turbine blades used in high pressure turbomachinery are subject to conditions of high temperature, triaxial steady and alternating stresses, fretting stresses in the blade attachment and damper contact locations, and exposure to high-pressure hydrogen. The blades are also subjected to extreme variations in temperature during start-up and shutdown transients. The most prevalent high cycle fatigue (HCF) failure modes observed in these blades during operation include crystallographic crack initiation/propagation on octahedral planes, and non-crystallographic initiation with crystallographic growth. Numerous cases of crack initiation and crack propagation at the blade leading edge tip, blade attachment regions, and damper contact locations have been documented. Understanding crack initiation/propagation under mixed-mode loading conditions is critical for establishing a systematic procedure for evaluating HCF life of single crystal turbine blades. This paper presents analytical and numerical techniques for evaluating two and three dimensional subsurface stress fields in anisotropic contacts. The subsurface stress results are required for evaluating contact fatigue life at damper contacts and dovetail attachment regions in single crystal nickel-base superalloy turbine blades. An analytical procedure is presented for evaluating the subsurface stresses in the elastic half-space, based on the adaptation of a stress function method outlined by Lekhnitskii. Numerical results are presented for cylindrical and spherical anisotropic contacts, using finite element analysis (FEA). Effects of crystal orientation on stress response and fatigue life are examined. Obtaining accurate subsurface stress results for anisotropic single crystal contact problems require extremely refined three-dimensional (3-D) finite element grids, especially in the edge of contact region. Obtaining resolved shear stresses (RSS) on the principal slip planes also involves
Apoptosis in Pneumovirus Infection
Directory of Open Access Journals (Sweden)
Reinout A. Bem
2013-01-01
Full Text Available Pneumovirus infections cause a wide spectrum of respiratory disease in humans and animals. The airway epithelium is the major site of pneumovirus replication. Apoptosis or regulated cell death, may contribute to the host anti-viral response by limiting viral replication. However, apoptosis of lung epithelial cells may also exacerbate lung injury, depending on the extent, the timing and specific location in the lungs. Differential apoptotic responses of epithelial cells versus innate immune cells (e.g., neutrophils, macrophages during pneumovirus infection can further contribute to the complex and delicate balance between host defense and disease pathogenesis. The purpose of this manuscript is to give an overview of the role of apoptosis in pneumovirus infection. We will examine clinical and experimental data concerning the various pro-apoptotic stimuli and the roles of apoptotic epithelial and innate immune cells during pneumovirus disease. Finally, we will discuss potential therapeutic interventions targeting apoptosis in the lungs.
Anisotropic microstructure near the sun
International Nuclear Information System (INIS)
Radio scattering observations provide a means of measuring a two-dimensional projection of the three-dimensional spatial spectrum of electron density, i.e., in the plane perpendicular to the line of sight. Earlier observations have shown that the microstructure at scales of the order of 10 km becomes highly field-aligned inside of 10 R· [Armstrong et al., 1990]. Earlier work has also shown that density fluctuations at scales larger than 1000 km have a Kolmogorov spectrum, whereas the smaller scale structure has a flatter spectrum and is considerably enhanced above the Kolmogorov ''background'' [Coles et al., 1991]. Here we present new observations made during 1990 and 1992. These confirm the earlier work, which was restricted to one source on a few days, but they suggest that the anisotropy changes abruptly near 6 R· which was not clear in the earlier data. The axial ratio measurements are shown on Figure 1 below. The new observations were made with a more uniform sampling of the spatial plane. They show that contours of constant correlation are elliptical. This is apparently inconsistent with the spatial correlation of the ISEE-3 magnetic field which shows a 'Maltese Cross' shape [Matthaeus et al., 1990]. However this inconsistency may be only apparent: the magnetic field and density correlations need not have the same shape; the scale of the magnetic field correlations is at least 4 orders of magnitude larger; they are much further from the sun; and they are point measurements whereas ours are path-integrated. We also made two simultaneous measurements, at 10 R·, of the anisotropy on scales of 200 to 4000 km. Significant anisotropy was seen on the smaller scales, but the larger scale structure was essentially isotropic. This suggests that the process responsible for the anisotropic microstructure is independent of the larger scale isotropic turbulence. It is then tempting to speculate that the damping of this anisotropic process inside of 6 R· contributes to
The Anisotropic Geometrodynamics For Cosmology
Siparov, Sergey V.
2009-05-01
The classical geometrodynamics (GRT) and its modern features based on the use of the Fridman-Robertson-Walker type metrics are still unable to explain several important issues of extragalactic observations like flat rotation curves of the spiral galaxies, Tully-Fisher law, globular clusters behavior in comparisson to that of the stars belonging to the galactic plane etc. The chalenging problem of the Universe expansion acceleration stemming from the supernovae observations demands the existence of the repulsion forces which brings one to the choice between the cosmological constant and some quintessence. The popular objects of discussion are now still dark (matter and energy), nevertheless, they are supposed to correspond to more than 95% of the Universe which seems to be far from satisfactory. According to the equivalence principle we can not experimentally distinguish between the inertial forces and the gravitational ones. Since there exist the inertial forces depending on velocity (Coriolis), it seems plausible to explore the velocity dependent gravitational forces. From the mathematical point of view it means that we should use the anisotropic metric. It immediately turns out that the expression for the Einstein-Hilbert action changes in a natural way - contrary to the cases of f(R)-theories, additional scalar fields, arbitrary MOND functions etc.. We use the linear approximation for the metric and derive the generalized geodesics and the equation for the gravity force that contains not only the Newton-Einstein term. The relation between the obtained results and those of Lense-Thirring approach are discussed. The resulting anisotropic geometrodynamics includes all the results of the GRT and is used to give the explanation to the problems mentioned above. One of the impressive consequences is the possibility to explain the observed Hubble red shift not by the Doppler effect as usually but by the gravitational red shift originating from the metric anisotropy.
Dental apoptosis: caspases behind
Czech Academy of Sciences Publication Activity Database
Matalová, Eva; Fleischmannová, Jana; Míšek, Ivan; Sharpe, P. T.; Tucker, A. S.
Ljubljana: ECDO, 2007, s. 26-26. [Euroconference on Apoptosis /15./ and Training Course on Concepts and Methods in Programmed Cell Death /4./. Portorož (SI), 26.10.2007-31.10.2007] R&D Projects: GA MŠk OC B23.001; GA AV ČR KJB500450503 Institutional research plan: CEZ:AV0Z50450515 Keywords : dental apoptosis Subject RIV: FF - HEENT, Dentistry
Subsurface Stress Fields In Single Crystal (Anisotropic) Contacts
Arakere, Nagaraj K.; Knudsen, Erik C.; Duke, Greg; Battista, Gilda; Swanson, Greg
2004-01-01
Single crystal superalloy turbine blades used in high pressure turbomachinery are subject to conditions of high temperature, triaxial steady and alternating stresses, fretting stresses in the blade attachment and damper contact locations, and exposure to high-pressure hydrogen. The blades are also subjected to extreme variations in temperature during start-up and shutdown transients. The most prevalent HCF failure modes observed in these blades during operation include crystallographic crack initiation/propagation on octahedral planes, and noncrystallographic initiation with crystallographic growth. Numerous cases of crack initiation and crack propagation at the blade leading edge tip, blade attachment regions, and damper contact locations have been documented. Understanding crack initiation/propagation under mixed-mode loading conditions is critical for establishing a systematic procedure for evaluating HCF life of single crystal turbine blades. This paper presents analytical and numerical techniques for evaluating two and three dimensional subsurface stress fields in anisotropic contacts. The subsurface stress results are required for evaluating contact fatigue life at damper contacts and dovetail attachment regions in single crystal nickel-base superalloy turbine blades. An analytical procedure is , presented, for evaluating the subsurface stresses in the elastic half-space, using a complex potential method outlined by Lekhnitskii. Numerical results are presented for cylindrical and spherical anisotropic contacts, using finite element analysis. Effects of crystal orientation on stress response and fatigue life are examined.
Derivation of anisotropic dissipative fluid dynamics from the Boltzmann equation
Molnár, Etele; Niemi, Harri; Rischke, Dirk H.
2016-06-01
Fluid-dynamical equations of motion can be derived from the Boltzmann equation in terms of an expansion around a single-particle distribution function which is in local thermodynamical equilibrium, i.e., isotropic in momentum space in the rest frame of a fluid element. However, in situations where the single-particle distribution function is highly anisotropic in momentum space, such as the initial stage of heavy-ion collisions at relativistic energies, such an expansion is bound to break down. Nevertheless, one can still derive a fluid-dynamical theory, called anisotropic dissipative fluid dynamics, in terms of an expansion around a single-particle distribution function, f^0 k, which incorporates (at least parts of) the momentum anisotropy via a suitable parametrization. We construct such an expansion in terms of polynomials in energy and momentum in the direction of the anisotropy and of irreducible tensors in the two-dimensional momentum subspace orthogonal to both the fluid velocity and the direction of the anisotropy. From the Boltzmann equation we then derive the set of equations of motion for the irreducible moments of the deviation of the single-particle distribution function from f^0 k. Truncating this set via the 14-moment approximation, we obtain the equations of motion of anisotropic dissipative fluid dynamics.
Anisotropic flow and flow fluctuations at the large hadron collider
Zhou, You
One of the fundamental questions in the phenomenology of Quantum Chromodynamics (QCD) is what the properties of matter are at the extreme densities and temperatures where quarks and gluons are in a new state of matter, the so-called Quark Gluon Plasma (QGP). Collisions of high-energy heavy-ions at the CERN Large Hadron Collider (LHC), allow us to create and study the properties of such a system in the laboratory. Anisotropic flow (vn) is strong evidence for the existence of QGP, and has been described as one of the most important observations measured in the ultra-relativistic heavy-ion collisions. In this thesis, the anisotropic flow of not only charged particles but also identified particles are presented. In addition, the investigations of correlations and fluctuations of both flow angle (symmetry plane) and magnitude were discussed. The main goal of this thesis is to understand the nature of anisotropic flow and its response to the initial geometry of the created system as well as its fluctuations.
Phenomenological Anisotropic Study of Surface Finish in Pack Rolling
Institute of Scientific and Technical Information of China (English)
无
2003-01-01
A phenomenological anisotropic model has been presented for the surface roughness modeling of pack rolling. The model is an assembly of grains in different orientations and sizes. The grain size is assumed to be in log-normal distribution. To model the macro anisotropic mechanical behavior of the grains induced by the slip deformation, the grains are assumed as isolated anisotropic units. The units have different mechanic behavior, and depend on the crystallographic orientations and the external loading as well as the interaction of the adjunctive grains. In the paper,the material properties of the grains are assumed as uniform distributions. The roughness of the contact surfaces depends on the distribution types and the scatters of the distributions. It is found that the initial roughness of the contact surfaces has a little influence on the surface roughness when the rolling deformation is large. The comparison between the phenomenological model and crystallographic model shows that the phenomenological model can also give out a reasonable result, while it only takes much less CPU time. The agreement between the single sheet model and the pack rolling model shows that in a certain degree the pack rolling model can be replaced by the single sheet model to decrease the CPU time.
Fabrication of anisotropic multifunctional colloidal carriers
Jerri, Huda A.
The field of colloidal assembly has grown tremendously in recent years, although the direct or template-assisted methods used to fabricate complex colloidal constructions from monodisperse micro- and nanoparticles have been generally demonstrated on model materials. In this work, novel core particle syntheses, particle functionalizations and bottom-up assembly techniques are presented to create functional colloidal devices. Using particle lithography, high-information colloidal vectors have been developed and modified with imaging and targeting agents. Localized nanoscale patches have been reliably positioned on microparticles to serve as foundations for further chemical or physical modifications. Site-specific placement of RGD targeting ligands has been achieved in these lithographed patches. Preferential uptake of these targeted vectors by RGD-specific 3T3 fibroblasts was verified using confocal laser scanning microscopy. A transition was made from the functionalization of model imaging core particles to the lithography of colloidal cartridges, in an effort to construct colloidal syringes with specialized, programmable release profiles. A variety of functional, pH-sensitive fluorescent cores were engineered to respond to solution conditions. When triggered, the diverse composite core microparticles and reservoir microcapsules released embedded fluorescent moieties such as dye molecules, and fluorophore-conjugated nanoparticles. The microcapsules, created using layer-by-layer polyelectrolyte deposition on sacrificial templates, were selectively modified with a robust coating. The pH-responsive anisotropic reservoir microcapsules were extremely stable in solution, and exhibited a "Lazarus" functionality of rehydrating to their original state following desiccation. A snapshot of focused-release of core constituents through the lone opening in colloidal monotremes has been obtained by anisotropically-functionalizing degradable cores with barrier shells. Additionally
Metformin induces apoptosis of pancreatic cancer cells
Institute of Scientific and Technical Information of China (English)
无
2008-01-01
AIM: To assess the role and mechanism of mefformin in inducing apoptosis of pancreatic cancer cells. METHODS: The human pancreatic cancer cell lines ASPC-1, BxPc-3, PANC-1 and SW1990 were exposed to mefformin. The inhibition of cell proliferation and colony formation via apoptosis induction and S phase arrest in pancreatic cancer cell lines of mefformin was tested.RESULTS: In each pancreatic cancer cell line tested, metformin inhibited cell proliferation in a dose dependent manner in MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium assays). Flow cytometric analysis showed that metformin reduced the number of cells in G1 and increased the percentage of cells in S phase as well as the apoptotic fraction. Enzymelinked immunosorbent assay (EUSA) showed that metformin induced apaptosis in all pancreatic cancer cell lines. In Western blot studies, metformin induced oly-ADP-ribose polymerase(PARP) cleavage (an indicator of aspase activation) in all pancreatic cancer cell lines. The general caspase inhibitor (VAD-fmk) completely abolished metformin-induced PARP cleavage and apoptosis in ASPC-1 BxPc-3 and PANC-1, the caspase-8 specific inhibitor (IETD-fmk) and the caspase-9 specific inhibitor (LEHD-fmk) only partially abrogated metformin-induced apoptosis and PARP cleavage in BxPc-3 and PANC-1 cells. We also observed that metformin treatment ramatically reduced epidermal growth factor receptor (EGFR) and phosphorylated mitogen activated protein kinase (P-MAPK) in both a time- and dose-dependent manner in all cell lines tested.CONCLUSION: Metformin significantly inhibits cell proliferation and apoptosis in all pancreatic cell lines. And the metformin-induced apoptosis is associated with PARP leavage, activation of caspase-3, -8, and -9 in a time- and dose-dependent manner. Hence, both caspase-8 and -9-initiated apoptotic signaling pathways contribute to metforrnin-induced apoptosis in pancreatic cell lines.
A new algorithm for anisotropic solutions
Indian Academy of Sciences (India)
M Chaisi; S D Maharaj
2006-02-01
We establish a new algorithm that generates a new solution to the Einstein field equations, with an anisotropic matter distribution, from a seed isotropic solution. The new solution is expressed in terms of integrals of an isotropic gravitational potential; and the integration can be completed exactly for particular isotropic seed metrics. A good feature of our approach is that the anisotropic solutions necessarily have an isotropic limit. We find two examples of anisotropic solutions which generalise the isothermal sphere and the Schwarzschild interior sphere. Both examples are expressed in closed form involving elementary functions only.
Anisotropic inflation in Gauss-Bonnet gravity
Lahiri, Sayantani
2016-01-01
We study anisotropic inflation with Gauss-Bonnet correction in presence of a massless vector field. In this scenario, exact anisotropic power-law inflation is realized when the inflaton potential, gauge coupling function and the Gauss-Bonnet coupling are exponential functions. We show that anisotropy becomes proportional to two slow-roll parameters of the theory and hence gets enhanced in presence of quadratic curvature corrections. The stability analysis reveals that anisotropic power-law solutions remain stable over a substantially large parameter region.
Variably saturated flow described with the anisotropic Lattice Boltzmann methods
Ginzburg, I.
2006-01-01
This paper addresses the numerical solution of highly nonlinear parabolic equations with Lattice Boltzmann techniques. They are first developed for generic advection and anisotropic dispersion equations (AADE). Collision configurations handle the anisotropic diffusion forms by using either anisotropic eigenvalue sets or anisotropic equilibrium functions. The coordinate transformation from the orthorhombic (rectangular) discretization grid to the cuboid computational grid is equivalen...
Self-catalyzed anisotropic growth of GaN spirals
Patsha, Avinash; Sahoo, Prasana; Dhara, S.; Tyagi, A. K.
2012-06-01
GaN spirals with homogeneous size are grown using chemical-vapor-deposition technique in a self catalytic process. Raman and photoluminescence (PL) studies reveal wurtzite GaN phase. Nucleation of GaN sphere takes place with the agglomeration Ga clusters and simultaneous reaction with NH3. A growth mechanism involving diffusion limited aggregation process initiating supersaturation and subsequent neck formation along with possible role of thermodynamic fluctuation in different crystalline facets of GaN, is described for the anisotropic spiral structures. Temperature dependent PL spectra show strong excitonic emissions along with the presence of free-to-bound transition.
Spatial interpolation approach based on IDW with anisotropic spatial structures
Li, Jia; Duan, Ping; Sheng, Yehua; Lv, Haiyang
2015-12-01
In many interpolation methods, with its simple interpolation principle, Inverse distance weighted (IDW) interpolation is one of the most common interpolation method. There are anisotropic spatial structures with actual geographical spatial phenomenon. When the IDW interpolation is used, anisotropic spatial structures should be considered. Geostatistical theory has a characteristics of exploring anisotropic spatial structures. In this paper, spatial interpolation approach based on IDW with anisotropic spatial structures is proposed. The DEM data is tested in this paper to prove reliability of the IDW interpolation considering anisotropic spatial structures. Experimental results show that IDW interpolation considering anisotropic spatial structures can improve interpolation precision when sampling data has anisotropic spatial structures feature.
Theory of Compton scattering by anisotropic electrons
Poutanen, Juri; Vurm, Indrek
2010-01-01
Compton scattering plays an important role in various astrophysical objects such as accreting black holes and neutron stars, pulsars, and relativistic jets, clusters of galaxies as well as the early Universe. In most of the calculations it is assumed that the electrons have isotropic angular distribution in some frame. However, there are situations where the anisotropy may be significant due to the bulk motions, or anisotropic cooling by synchrotron radiation, or anisotropic source of seed so...
Phase space analysis in anisotropic optical systems
Rivera, Ana Leonor; Chumakov, Sergey M.; Wolf, Kurt Bernardo
1995-01-01
From the minimal action principle follows the Hamilton equations of evolution for geometric optical rays in anisotropic media. As in classical mechanics of velocity-dependent potentials, the velocity and the canonical momentum are not parallel, but differ by an anisotropy vector potential, similar to that of linear electromagnetism. Descartes' well known diagram for refraction is generalized and a factorization theorem holds for interfaces between two anisotropic media.
Anisotropic rectangular metric for polygonal surface remeshing
Pellenard, Bertrand
2013-06-18
We propose a new method for anisotropic polygonal surface remeshing. Our algorithm takes as input a surface triangle mesh. An anisotropic rectangular metric, defined at each triangle facet of the input mesh, is derived from both a user-specified normal-based tolerance error and the requirement to favor rectangle-shaped polygons. Our algorithm uses a greedy optimization procedure that adds, deletes and relocates generators so as to match two criteria related to partitioning and conformity.
Rainbow metric from quantum gravity: anisotropic cosmology
Assanioussi, Mehdi; Dapor, Andrea
2016-01-01
In this paper we present a construction of effective cosmological models which describe the propagation of a massive quantum scalar field on a quantum anisotropic cosmological spacetime. Each obtained effective model is represented by a rainbow metric in which particles of distinct momenta propagate on different classical geometries. Our analysis shows that upon certain assumptions and conditions on the parameters determining such anisotropic models, we surprisingly obtain a unique deformatio...
Anisotropic cosmological solutions in massive vector theories
Heisenberg, Lavinia; Kase, Ryotaro; Tsujikawa, Shinji
2016-01-01
In beyond-generalized Proca theories including the extension to theories higher than second order, we study the role of a spatial component $v$ of a massive vector field on the anisotropic cosmological background. We show that, as in the case of the isotropic cosmological background, there is no additional ghostly degrees of freedom associated with the Ostrogradski instability. In second-order generalized Proca theories we find the existence of anisotropic solutions on which the ratio between...
Anisotropic Stars: Exact Solutions and Stability
Dev, Krsna; Gleiser, Marcelo
2004-01-01
I report on recent work concerning the existence and stability of self-gravitating spheres with anisotropic pressure. After presenting new exact solutions, Chandrasekhar's variational formalism for radial perturbations is generalized to anisotropic objects and applied to investigate their stability. It is shown that anisotropy can not only support stars of mass M and radius R with 2M/R > 8/9 and arbitrarily large surface redshifts, but that stable configurations exist for values of the adiaba...
Anisotropic surface tension of buckled fluid membrane
Noguchi, Hiroshi
2011-01-01
Solid sheets and fluid membranes exhibit buckling under lateral compression. Here, it is revealed that fluid membranes have anisotropic buckling surface tension contrary to solid sheets. Surprisingly, the surface tension perpendicular to the buckling direction shows stronger dependence than that parallel to it. Our theoretical predictions are supported by numerical simulations of a meshless membrane model. This anisotropic tension can be used to measure the membrane bending rigidity. It is al...
Highly anisotropic elements for acoustic pentamode applications.
Layman, Christopher N; Naify, Christina J; Martin, Theodore P; Calvo, David C; Orris, Gregory J
2013-07-12
Pentamode metamaterials are a class of acoustic metafluids that are characterized by a divergence free modified stress tensor. Such materials have an unconventional anisotropic stiffness and isotropic mass density, which allow themselves to mimic other fluid domains. Here we present a pentamode design formed by an oblique honeycomb lattice and producing customizable anisotropic properties. It is shown that anisotropy in the stiffness can exceed 3 orders of magnitude, and that it can be realistically tailored for transformation acoustic applications. PMID:23889408
Anisotropic fluid spheres in general relativity
International Nuclear Information System (INIS)
A procedure is developed to find static solutions for anisotropic fluid spheres from known static solutions for perfect fluid spheres. The method is used to obtain four exact analytical solutions of Einstein's equations for spherically symmetric self-gravitating distribution of anisotropic matter. The solutions are matched to the Schwarzschild exterior metric. The physical features of one of the solutions are briefly discussed. Many previously known perfect fluid solutions are derived as particular cases. (author)
On the anisotropic elastic properties of hydroxyapatite.
Katz, J. L.; Ukraincik, K.
1971-01-01
Experimental measurements of the isotropic elastic moduli on polycrystalline specimens of hydroxyapatite and fluorapatite are compared with elastic constants measured directly from single crystals of fluorapatite in order to derive a set of pseudo single crystal elastic constants for hydroxyapatite. The stiffness coefficients thus derived are given. The anisotropic and isotropic elastic properties are then computed and compared with similar properties derived from experimental observations of the anisotropic behavior of bone.
Soft particles with anisotropic interactions
Schurtenberger, Peter
Responsive colloids such as thermo- or pH-sensitive microgels are ideal model systems to investigate the relationship between the nature of interparticle interactions and the plethora of self-assembled structures that can form in colloidal suspensions. They allow for a variation of the form, strength and range of the interaction potential almost at will. While microgels have extensively been used as model systems to investigate various condensed matter problems such as glass formation, jamming or crystallization, they can also be used to study systems with anisotropic interactions. Here we show results from a systematic investigation of the influence of softness and anisotropy on the structural and dynamic properties of strongly interacting suspensions. We focus first on ionic microgels. Due to their large number of internal counterions they possess very large polarisabilities, and we can thus use external electrical ac fields to generate large dipolar contributions to the interparticle interaction potential. This leads to a number of new crystal phases, and we can trigger crystal-crystal phase transitions through the appropriate choice of the field strength. We then show that this approach can be extended to more complex particle shapes in an attempt to copy nature's well documented success in fabricating complex nanostructures such as virus shells via self assembly. European Research Council (ERC-339678-COMPASS).
Transport theory in anisotropic media
International Nuclear Information System (INIS)
A theory of particle scattering in anisotropic media is developed. That is, a medium in which the microstructure causes the mean free paths of the particles to become dependent on their direction of motion with respect to some fixed axis. The equation which results is similar to the normal, one-speed Boltzmann transport equation but has cross-sections which are functions of direction. This equation is solved for arbitrary cross-sectional dependence on direction in plane geometry. Four distinct problems are considered: (1) the particle distribution arising from a plane source in an infinite medium, (2) the albedo problem and Milne problem for a half-space and the corresponding 'thick slab' transmission problem, (3) solution of the integral form of the Boltzmann equation for a special case of cross-sectional dependence which leads to results similar to the well-known rod model and (4) the energy spectrum of particles slowing down from a high energy source by elastic collisions. In each of these four problems the influence of the cross-section is seen to be significant in comparison with the conventional constant cross-section results, to which they revert in this limit. Some suggestions about physical applications of the results are made. (author)
Anisotropic diffusion-limited aggregation.
Popescu, M N; Hentschel, H G E; Family, F
2004-06-01
Using stochastic conformal mappings, we study the effects of anisotropic perturbations on diffusion-limited aggregation (DLA) in two dimensions. The harmonic measure of the growth probability for DLA can be conformally mapped onto a constant measure on a unit circle. Here we map m preferred directions for growth to a distribution on the unit circle, which is a periodic function with m peaks in [-pi,pi) such that the angular width sigma of the peak defines the "strength" of anisotropy kappa= sigma(-1) along any of the m chosen directions. The two parameters (m,kappa) map out a parameter space of perturbations that allows a continuous transition from DLA (for small enough kappa ) to m needlelike fingers as kappa--> infinity. We show that at fixed m the effective fractal dimension of the clusters D(m,kappa) obtained from mass-radius scaling decreases with increasing kappa from D(DLA) approximately 1.71 to a value bounded from below by D(min) = 3 / 2. Scaling arguments suggest a specific form for the dependence of the fractal dimension D(m,kappa) on kappa for large kappa which compares favorably with numerical results. PMID:15244564
Anisotropic pressure and hyperons in neutron stars
Sulaksono, A
2014-01-01
We study the effects of anisotropic pressure on properties of the neutron stars with hyperons inside its core within the framework of extended relativistic mean field. It is found that the main effects of anisotropic pressure on neutron star matter is to increase the stiffness of the equation of state, which compensates for the softening of the EOS due to the hyperons. The maximum mass and redshift predictions of anisotropic neutron star with hyperonic core are quite compatible with the result of recent observational constraints if we use the parameter of anisotropic pressure model $h \\le 0.8$[1] and $\\Lambda \\le -1.15$ [2]. The radius of the corresponding neutron star at $M$=1.4 $M_\\odot$ is more than 13 km, while the effect of anisotropic pressure on the minimum mass of neutron star is insignificant. Furthermore, due to the anisotropic pressure in the neutron star, the maximum mass limit of higher than 2.1 $M_\\odot$ cannot rule out the presence of hyperons in the neutron star core.
Florkowski, Wojciech; Ryblewski, Radoslaw
2010-01-01
We introduce a new framework of highly-anisotropic hydrodynamics that includes dissipation effects. Dissipation is defined by the form of the entropy source that depends on the pressure anisotropy and vanishes for the isotropic fluid. With a simple ansatz for the entropy source obeying general physical requirements, we are led to a non-linear equation describing the time evolution of the anisotropy in purely-longitudinal boost-invariant systems. Matter that is initially highly anisotropic app...
International Nuclear Information System (INIS)
Equitoxic doses (10% clonogenic survival) of UV radiation (UVR) from the three waveband regions, i.e. UVA1 (340-400 nm), UVB (290-320 nm) and UVC (200-290 nm), were shown to induce immediate or delayed apoptosis in L5178Y-R murine lymphoma cells. Membrane and DNA damage were shown to be the most probable initiators of UVA1-induced immediate or UVR-induced delayed apoptosis, respectively. These UV-induced apoptotic processes appeared to utilize two different ''core'' biochemical mechanisms; however, one core mechanism could be initiated at two distinct sites (e.g. membrane or DNA) and result in disparate kinetics. In an attempt to resolve this mechanistic issue, the dependence on macromolecular synthesis of each UV-induced apoptotic mechanism was investigated. In the absence of UVR, inhibition of either transcription (actinomycin D) or translation (cycloheximide) induced apoptosis in a concentration-and time-dependent manner. These results suggest that an apoptotic mechanism exists that does not require macromolecular synthesis postinsult (constitutive). The UVR data demonstrate that UVA-1 induced immediate apoptosis utilizes this constitutive mechanism (preprogrammed), while UVR-induced delayed apoptosis utilizes the well-known inducible mechanism (programmed). Therefore, there are two different core biochemical mechanisms of apoptotic death available to each cell: preprogrammed (constitutive) and programmed (inducible) cell death. (Author)
Apoptosis: una muerte silenciosa
Isis Casadelvalle Pérez
2006-01-01
La apoptosis o muerte celular programada es un tipo de muerte presente en todas las células eucarióticas. Es un proceso ordenado y esencial del desarrollo normal y de mantenimiento de la homeostasis de un organismo. En el presente trabajo se resumen las principales características fisiológicas, bioquímicas y moleculares de la muerte por apoptosis, evento que ocurre de forma apagada o silenciosa, o sea, sin daño celular aparente diferenciándose claramente del proceso de necrosis celular. En es...
Wang, Jing; Hu, Xiao-Song; Shi, Jie-Ping
2003-07-01
Over the last decade, considerable progress has been made in the study of sphingolipids with the development of biological techniques. Sphingolipids play important roles in diverse physiological process, including cytoskeleton migration, angiogenesis, embryonic development and signal transduction. Except for this, the lastest evidence has suggested that sphingolipids and their metabolite (ceramide, sphingosine, sphingosine 1-phosphate) can induce apoptosis in a wide variety of tumor cell lines such as LoVo HT29, Bel7402, A549, CNE2 cells. This paper is attempted to review the recent advances of investigation into the relationship between sphingolipids and apoptosis. PMID:14628466
Interpolation, embeddings and traces of anisotropic fractional Sobolev spaces with temporal weights
Meyries, Martin; Schnaubelt, Roland
2012-01-01
We investigate the properties of a class of weighted vector-valued $L_p$-spaces and the corresponding (an)isotropic Sobolev-Slobodetskii spaces. These spaces arise naturally in the context of maximal $L_p$-regularity for parabolic initial-boundary value problems. Our main tools are operators with a bounded $\\calH^\\infty$-calculus, interpolation theory, and operator sums.
Anisotropic Pressures at Ultra-stiff Singularities and the Stability of Cyclic Universes
Barrow, John D
2010-01-01
We show that the inclusion of simple anisotropic pressures stops the isotropic Friedmann universe being a stable attractor as an initial or final singularity is approached when pressures can exceed the energy density. This shows that the situation with isotropic pressures, studied earlier in the context of cyclic and ekpyrotic cosmologies, is not generic, and Kasner-like behaviour occurs when simple pressure anisotropies are present. We find all the asymptotic behaviours and determine the dynamics when the anisotropic principal pressures are proportional to the density. We expect distortions and anisotropies to be significantly amplified through a simple cosmological bounce in cyclic or ekpyrotic cosmologies when ultra-stiff pressures are present.
Damage spreading in 2-dimensional isotropic and anisotropic Bak-Sneppen models
Bakar, B.; Tirnakli, U.
2008-03-01
We implement the damage spreading technique on 2-dimensional isotropic and anisotropic Bak-Sneppen models. Our extensive numerical simulations show that there exists a power-law sensitivity to the initial conditions at the statistically stationary state (self-organized critical state). Corresponding growth exponent α for the Hamming distance and the dynamical exponent z are calculated. These values allow us to observe a clear data collapse of the finite size scaling for both versions of the Bak-Sneppen model. Moreover, it is shown that the growth exponent of the distance in the isotropic and anisotropic Bak-Sneppen models is strongly affected by the choice of the transient time.
Formation of lopsided and bar structures in non-stationary gravitating systems: II-anisotropic case
International Nuclear Information System (INIS)
In the present study, growth rates of non-stationary model of radially gravitating disk with an anisotropic velocity diagram is constructed. We have focused on two oscillation modes i.e. lopsided and bar-like modes. Critical diagrams of the initial virial ratio and rotation parameter are obtained for these two perturbation oscillation modes. A comparative analysis shows that lopsided mode again dominate the bar-like mode, like its isotropic case, against all the values of rotation parameter for anisotropic non-stationary model. (author)
Surface and defect morphologies in anisotropic elastic and piezoelectric solids
Energy Technology Data Exchange (ETDEWEB)
Gao, Huajian; Barnett, D.M. [Stanford Univ., CA (United States)
1996-12-31
The authors investigate issues related to the equilibrium and stability of surface and line defect morphologies in both piezoelectric and anisotropic elastic solids. Following their previous efforts which established that mechanical stresses in purely elastic solids can promote instability of an initially flat surface with respect to surface roughening, they show that the (initially flat) interface between two dissimilar piezoelectric solids can be unstable when subjected to coupled electromechanical loading. Quite recent cross-sectional observations of electrodeposited thin films by Japanese and British researchers provide experimental confirmation of these predictions. The authors also investigate the occurrence of equilibrium arrangements (zero Peach-Koehler force arrangements) of line defects (dislocations) in anisotropic elastic crystals in the absence of externally applied stresses. Contrary to prevailing opinion, equilibrium arrangements of dislocations under no externally applied stresses appear to be the rule rather than the exception. The existence of such {open_quotes}zero stress arrangements{close_quotes} is fundamental to developing micromechanical models of plastically deforming solids.
Directory of Open Access Journals (Sweden)
C. Haanen
1995-01-01
Full Text Available During the last few decades it has been recognized that cell death is not the consequence of accidental injury, but is the expression of a cell suicide programme. Kerr et al. (1972 introduced the term apoptosis. This form of cell death is under the influence of hormones, growth factors and cytokines, which depending upon the receptors present on the target cells, may activate a genetically controlled cell elimination process. During apoptosis the cell membrane remains intact and the cell breaks into apoptotic bodies, which are phagocytosed. Apoptosis, in contrast to necrosis, is not harmful to the host and does not induce any inflammatory reaction. The principal event that leads to inflammatory disease is cell damage, induced by chemical/physical injury, anoxia or starvation. Cell damage means leakage of cell contents into the adjacent tissues, resulting in the capillary transmigration of granulocytes to the injured tissue. The accumulation of neutrophils and release of enzymes and oxygen radicals enhances the inflammatory reaction. Until now there has been little research into the factors controlling the accumulation and the tissue load of granulocytes and their histotoxic products in inflammatory processes. Neutrophil apoptosis may represent an important event in the control of intlamtnation. It has been assumed that granulocytes disintegrate to apoptotic bodies before their fragments are removed by local macrophages. Removal of neutrophils from the inflammatory site without release of granule contents is of paramount importance for cessation of inflammation. In conclusion, apoptotic cell death plays an important role in inflammatory processes and in the resolution of inflammatory reactions. The facts known at present should stimulate further research into the role of neutrophil, eosinophil and macrophage apoptosis in inflammatory diseases.
Anisotropic thermal conductivity of magnetic fluids
Institute of Scientific and Technical Information of China (English)
Xiaopeng Fang; Yimin Xuan; Qiang Li
2009-01-01
Considering the forces acting on the particles and the motion of the particles, this study uses a numerical simulation to investigate the three-dimensional microstructure of the magnetic fluids in the presence of an external magnetic field. A method is proposed for predicting the anisotropic thermal conductivity of magnetic fluids. By introducing an anisotropic structure parameter which characterizes the non-uniform distribution of particles suspended in the magnetic fluids, the traditional Maxwell formula is modified and extended to calculate anisotropic thermal conductivity of the magnetic fluids. The results show that in the presence of an external magnetic field the magnetic nanoparticles form chainlike clusters along the direction of the external magnetic field, which leads to the fact that the thermal conduc-tivity of the magnetic fluid along the chain direction is bigger than that along other directions. The thermal conductivity of the magnetic fluids presents an anisotropic feature. With the increase of the magnetic field strength the chainlike clusters in the magnetic fluid appear to be more obvious, so that the anisotropic feature of heat conduction in the fluids becomes more evident.
Effective medium theory for anisotropic metamaterials
Zhang, Xiujuan
2015-01-20
Materials with anisotropic material parameters can be utilized to fabricate many fascinating devices, such as hyperlenses, metasolids, and one-way waveguides. In this study, we analyze the effects of geometric anisotropy on a two-dimensional metamaterial composed of a rectangular array of elliptic cylinders and derive an effective medium theory for such a metamaterial. We find that it is possible to obtain a closed-form analytical solution for the anisotropic effective medium parameters, provided the aspect ratio of the lattice and the eccentricity of the elliptic cylinder satisfy certain conditions. The derived effective medium theory not only recovers the well-known Maxwell-Garnett results in the quasi-static regime, but is also valid beyond the long-wavelength limit, where the wavelength in the host medium is comparable to the size of the lattice so that previous anisotropic effective medium theories fail. Such an advance greatly broadens the applicable realm of the effective medium theory and introduces many possibilities in the design of structures with desired anisotropic material characteristics. A real sample of a recently theoretically proposed anisotropic medium, with a near-zero index to control the flux, is achieved using the derived effective medium theory, and control of the electromagnetic waves in the sample is clearly demonstrated.
Shear-free Anisotropic Cosmological Models in f(R) Gravity
Abebe, Amare; Myrzakulov, Ratbay
2015-01-01
We study a class of shear-free, homogeneous but anisotropic cosmological models with imperfect matter sources in the context of f(R) gravity. We show that the anisotropic stresses are related to the electric part of the Weyl tensor in such a way that they balance each other. We also show that within the class of orthogonal f(R) models, small perturbations of shear are damped, and that the electric part of the Weyl tensor and the anisotropic stress tensor decay with the expansion as well as the heat flux of the curvature fluid. Specializing in locally rotationally symmetric spacetimes in orthonormal frames, we examine the late-time behaviour of the de Sitter universe in $f(R)$ gravity. For the Starobinsky model of f(R), we study the evolutionary behavior of the Universe by numerically integrating the Friedmann equation, where the initial conditions for the expansion, acceleration and jerk parameters are taken from observational data.
General Expression of Elastic Tensor for Anisotropic Materials
Institute of Scientific and Technical Information of China (English)
HUANG Bo
2005-01-01
In order to formulate a general expression of elastic tensor for anisotropic materials, a method of tensor derivative is used for determining relationship between fourth-order elastic tensor and second-order structure tensor that has satisfied material symmetrical conditions. From this general expression of elastic tensor, specific expressions of elastic tensor for different anisotropic materials, such as isotropic materials, transverse isotropic materials and orthogonal-anisotropic materials, can be deduced. This expression underlies the scalar description of anisotropic factors, which are used for classifying and analyzing anisotropic materials. Cubic crystals are analyzed macroscopically by means of the general expression and anisotropic factor.
Wnt signaling control of bone cell apoptosis
Institute of Scientific and Technical Information of China (English)
Peter V N Bodine
2008-01-01
Wnts are a large family of growth factors that mediate essential biological processes like embryogenesis, morphogenesis and organogenesis. These proteins also play a role in oncogenesis, and they regulate apoptosis in many tissues. Wnts bind to a membrane receptor complex comprised of a frizzled (FZD) G-protein-coupled receptor and a low-density , lipoprotein (LDL) receptor-related protein (LRP). The formation of this ligand-receptor complex initiates a number of signaling cascades that include the canonical/beta-catenin pathway as well as several noncanonical pathways. In recent years, canonical Wnt signaling has been reported to play a significant role in the control of bone formation. Clinical studies have found that mutations in LRP-5 are associated with reduced bone mineral density (BMD) and fractures. Investigations of knockout and transgenic mouse models of Wnt pathway components have shown that canonical Wnt signaling modulates most aspects of osteoblast physiology including proliferation, differentiation, function and apoptosis. Transgenic mice expressing a gain of function mutant of LRP-5 in bone, or mice lacking the Wnt antagonist secreted frizzled-related protein-1, exhibit elevated BMD and suppressed osteoblast apoptosis. In addition, preclinical studies with pharmacologic compounds such as those that inhibit glycogen synthase kinase-3p support the importance of the canonical Wnt pathway in modulation of bone formation and osteoblast apoptosis.
Quasiparticle anisotropic hydrodynamics for central collisions
Alqahtani, Mubarak; Strickland, Michael
2016-01-01
We use quasiparticle anisotropic hydrodynamics to study an azimuthally-symmetric boost-invariant quark-gluon plasma including the effects of both shear and bulk viscosities. In quasiparticle anisotropic hydrodynamics, a single finite-temperature quasiparticle mass is introduced and fit to the lattice data in order to implement a realistic equation of state. We compare results obtained using the quasiparticle method with the standard method of imposing the equation of state in anisotropic hydrodynamics and viscous hydrodynamics. Using these three methods, we extract the primordial particle spectra, total number of charged particles, and average transverse momentum for various values of the shear viscosity to entropy density ratio eta/s. We find that the three methods agree well for small shear viscosity to entropy density ratio, eta/s, but differ at large eta/s. We find, in particular, that when using standard viscous hydrodynamics, the bulk-viscous correction can drive the primordial particle spectra negative...
Theory of Compton scattering by anisotropic electrons
Poutanen, Juri
2010-01-01
Compton scattering plays an important role in various astrophysical objects such as accreting black holes and neutron stars, pulsars, and relativistic jets, clusters of galaxies as well as the early Universe. In most of the calculations it is assumed that the electrons have isotropic angular distribution in some frame. However, there are situations where the anisotropy may be significant due to the bulk motions, or anisotropic cooling by synchrotron radiation, or anisotropic source of seed soft photons. We develop here an analytical theory of Compton scattering by anisotropic distribution of electrons that can simplify significantly the calculations. Assuming that the electron angular distribution can be represented by a second order polynomial over cosine of some angle (dipole and quadrupole anisotropy), we integrate the exact Klein-Nishina cross-section over the angles. Exact analytical and approximate formulae valid for any photon and electron energies are derived for the redistribution functions describin...
Anisotropic pseudopotential for polarized dilute quantum gases
International Nuclear Information System (INIS)
An anisotropic pseudopotential arising in the context of collisions of two particles polarized by an external field is rigorously derived and its properties are investigated. Such a low-energy pseudopotential may be useful in describing collective properties of dilute quantum gases, such as molecules polarized by an electric field or metastable 3P2 atoms polarized by a magnetic field. The pseudopotential is expressed in terms of the reactance (K) matrix and derivatives of the Dirac δ function. In most applications, it may be represented as a sum of a traditional spherically symmetric contact term and an anisotropic part. The former contribution may be parametrized by a generalized scattering length. The anisotropic part of the pseudopotential may be characterized by the off-diagonal scattering length for dipolar interactions and off-diagonal scattering volume for quadrupolar interactions. The two-body matrix element of the pseudopotential in a basis of plane waves is also derived
Anisotropic inflation in the Finsler spacetime
International Nuclear Information System (INIS)
We suggest the universe is Finslerian in the stage of inflation. The Finslerian background spacetime breaks rotational symmetry and induces parity violation. The primordial power spectrum is given for the quantum fluctuation of the inflation field. It depends not only on the magnitude of the wavenumber but also on the preferred direction. We derive the gravitational field equations in the perturbed Finslerian background spacetime, and we obtain a conserved quantity outside the Hubble horizon. The angular correlation coefficients are presented in our anisotropic inflation model. The parity violation feature of Finslerian background spacetime requires that the anisotropic effect only appears in the angular correlation coefficients if l' = l + 1. The numerical results of the angular correlation coefficients are given describing the anisotropic effect. (orig.)
Obtuse triangle suppression in anisotropic meshes
Sun, Feng
2011-12-01
Anisotropic triangle meshes are used for efficient approximation of surfaces and flow data in finite element analysis, and in these applications it is desirable to have as few obtuse triangles as possible to reduce the discretization error. We present a variational approach to suppressing obtuse triangles in anisotropic meshes. Specifically, we introduce a hexagonal Minkowski metric, which is sensitive to triangle orientation, to give a new formulation of the centroidal Voronoi tessellation (CVT) method. Furthermore, we prove several relevant properties of the CVT method with the newly introduced metric. Experiments show that our algorithm produces anisotropic meshes with much fewer obtuse triangles than using existing methods while maintaining mesh anisotropy. © 2011 Elsevier B.V. All rights reserved.
Micromechanics and dislocation theory in anisotropic elasticity
Lazar, Markus
2016-01-01
In this work, dislocation master-equations valid for anisotropic materials are derived in terms of kernel functions using the framework of micromechanics. The second derivative of the anisotropic Green tensor is calculated in the sense of generalized functions and decomposed into a sum of a $1/R^3$-term plus a Dirac $\\delta$-term. The first term is the so-called "Barnett-term" and the latter is important for the definition of the Green tensor as fundamental solution of the Navier equation. In addition, all dislocation master-equations are specified for Somigliana dislocations with application to 3D crack modeling. Also the interior Eshelby tensor for a spherical inclusion in an anisotropic material is derived as line integral over the unit circle.
Asymmetric Composite Nanoparticles with Anisotropic Surface Functionalities
Directory of Open Access Journals (Sweden)
Donglu Shi
2009-01-01
Full Text Available Asymmetric inorganic/organic composite nanoparticles with anisotropic surface functionalities represent a new approach for creating smart materials, requiring the selective introduction of chemical groups to dual components of composite, respectively. Here, we report the synthesis of snowman-like asymmetric silica/polystyrene heterostructure with anisotropic functionalities via a chemical method, creating nanostructure possibly offering two-sided biologic accessibility through the chemical groups. Carboxyl group was introduced to polystyrene component of the snowman-like composites by miniemulsion polymerization of monomer on local surface of silica particles. Moreover, amino group was then grafted to remained silica surface through facile surface modification of the composite nanoparticles. The asymmetric shape of these composites was confirmed by TEM characterization. Moreover, characteristics of anisotropic surface functionalities were indicated by Zeta potential measurement and confocal laser microscopy after being labeled with fluorescent dyes. This structure could find potential use as carriers for biological applications.
Anisotropic inflation in the Finsler spacetime
Energy Technology Data Exchange (ETDEWEB)
Li, Xin [Chongqing University, Department of Physics, Chongqing (China); Institute of Theoretical Physics, Chinese Academy of Sciences, State Key Laboratory of Theoretical Physics, Beijing (China); Wang, Sai [Institute of Theoretical Physics, Chinese Academy of Sciences, State Key Laboratory of Theoretical Physics, Beijing (China); Chang, Zhe [Institute of Theoretical Physics, Chinese Academy of Sciences, State Key Laboratory of Theoretical Physics, Beijing (China); Institute of High Energy Physics, Chinese Academy of Sciences, Beijing (China)
2015-06-15
We suggest the universe is Finslerian in the stage of inflation. The Finslerian background spacetime breaks rotational symmetry and induces parity violation. The primordial power spectrum is given for the quantum fluctuation of the inflation field. It depends not only on the magnitude of the wavenumber but also on the preferred direction. We derive the gravitational field equations in the perturbed Finslerian background spacetime, and we obtain a conserved quantity outside the Hubble horizon. The angular correlation coefficients are presented in our anisotropic inflation model. The parity violation feature of Finslerian background spacetime requires that the anisotropic effect only appears in the angular correlation coefficients if l' = l + 1. The numerical results of the angular correlation coefficients are given describing the anisotropic effect. (orig.)
Linjiang, QIN; Changfu, YANG
2016-03-01
The rocks in the crust and the upper mantle of the Earth are believed to exhibit electrical anisotropy to some extent. It is beneficial to further understand and recognize the propagation of the electromagnetic waves in the Earth by investigating the magnetotelluric (which is one of the main geophysical techniques to probe the deep structures in the Earth) responses of the media with anisotropic conductivity structures. In the present study, we examine the magnetotelluric fields over an idealized 2-D model consisting of two segments with axially anisotropic conductivity structures overlying a perfect conductor basement by a quasi-static analytic approach. The resulting analytic solution could not only contribute to the electromagnetic induction theory in the anisotropic Earth but also serve as at least an initial standard solution which could be used to validate the reliability and accuracy of the numerical algorithms developed for modeling the magnetotelluric responses of the 2-D media with much more general anisotropic conductivity.
Qin, Linjiang; Yang, Changfu
2016-06-01
The rocks in the crust and the upper mantle of the Earth are believed to exhibit electrical anisotropy to some extent. It is beneficial to further understand and recognize the propagation of the electromagnetic waves in the Earth by investigating the magnetotelluric (which is one of the main geophysical techniques to probe the deep structures in the Earth) responses of the media with anisotropic conductivity structures. In this study, we examine the magnetotelluric fields over an idealized 2-D model consisting of two segments with axially anisotropic conductivity structures overlying a perfect conductor basement by a quasi-static analytic approach. The resulting analytic solution could not only contribute to the electromagnetic induction theory in the anisotropic Earth but also serve as at least an initial standard solution which could be used to validate the reliability and accuracy of the numerical algorithms developed for modelling the magnetotelluric responses of the 2-D media with much more general anisotropic conductivity.
Bouncing Anisotropic Universes with Varying Constants
Barrow, John D
2013-01-01
We examine the evolution of a closed, homogeneous and anisotropic cosmology subject to a variation of the fine structure 'constant', \\alpha, within the context of the theory introduced by Bekenstein, Sandvik, Barrow and Magueijo, which generalises Maxwell's equations and general relativity. The variation of \\alpha permits an effective ghost scalar field, whose negative energy density becomes dominant at small length scales, leading to a bouncing cosmology. A thermodynamically motivated coupling which describes energy exchange between the effective ghost field and the radiation field leads to an expanding, isotropizing sequence of bounces. In the absence of entropy production we also find solutions with stable anisotropic oscillations around a static universe.
One-Dimensional Anisotropic Band Gap Structure
Institute of Scientific and Technical Information of China (English)
无
2000-01-01
The band gap structure of one-dimensional anisotropic photonic crystal has been studied by means of the transfer matrix formalism. From the analytic expressions and numeric calculations we see some general characteristics of the band gap structure of anisotropic photonic crystals, each band separates into two branches and the two branches react to polarization sensitively. In the practical case of oblique incidence, gaps move towards high frequency when the angle of incidence increases. Under some special conditions, the two branches become degenerate again.
Anisotropic Stars: Exact Solutions and Stability
Dev, K; Dev, Krsna; Gleiser, Marcelo
2004-01-01
I report on recent work concerning the existence and stability of self-gravitating spheres with anisotropic pressure. After presenting new exact solutions, Chandrasekhar's variational formalism for radial perturbations is generalized to anisotropic objects and applied to investigate their stability. It is shown that anisotropy can not only support stars of mass M and radius R with 2M/R > 8/9 and arbitrarily large surface redshifts, but that stable configurations exist for values of the adiabatic index smaller than the corresponding isotropic value.
Evolution of multidimensional flat anisotropic cosmological models
International Nuclear Information System (INIS)
We study the dynamics of a flat multidimensional anisotropic cosmological model filled with an anisotropic fluidlike medium. By an appropriate choice of variables, the dynamical equations reduce to a two-dimensional dynamical system. We present a detailed analysis of the time evolution of this system and the conditions of the existence of spacetime singularities. We investigate the conditions under which violent, exponential, and power-law inflation is possible. We show that dimensional reduction cannot proceed by anti-inflation (rapid contraction of internal space). Our model indicates that it is very difficult to achieve dimensional reduction by classical means
CAVITATION BIFURCATION FOR COMPRESSIBLE ANISOTROPIC HYPERELASTIC MATERIALS
Institute of Scientific and Technical Information of China (English)
ChengChangjun; RenJiusheng
2004-01-01
The effect of material anisotropy on the bifurcation for void tormation in anisotropic compressible hyperelastic materials is examined. Numerical solutions are obtained in an anisotropic sphere, whose material is transversely isotropic in the radial direction. It is shown that the bifurcation may occur either to the right or to the left, depending on the degree of material anisotropy. The deformation and stress contribution in the sphere before cavitation are different from those after cavitation. The stability of solutions is discussed through a comparison of energy.
Relativistic Solutions of Anisotropic Compact Objects
Paul, Bikash Chandra
2016-01-01
We present a class of new relativistic solutions with anisotropic fluid for compact stars in hydrostatic equilibrium. The interior space-time geometry considered here for compact objects are described by parameters namely, $\\lambda$, $k$, $A$, $R$ and $n$. The values of the geometrical parameters are determined here for obtaining a class of physically viable stellar models. The energy-density, radial pressure and tangential pressure are finite and positive inside the anisotropic stars. Considering some stars of known mass we present stellar models which describe compact astrophysical objects with nuclear density.
Anisotropic nanomaterials preparation, properties, and applications
Li, Quan
2015-01-01
In this book anisotropic one-dimensional and two-dimensional nanoscale building blocks and their assembly into fascinating and qualitatively new functional structures embracing both hard and soft components are explained. Contributions from leading experts regarding important aspects like synthesis, assembly, properties and applications of the above materials are compiled into a reference book. The anisotropy, i.e. the direction-dependent physical properties, of materials is fascinating and elegant and has sparked the quest for anisotropic materials with useful properties. With such a curiosi
Directory of Open Access Journals (Sweden)
M. A. Orlova
2013-01-01
Full Text Available Fullerene derivatives superfamily attracts a serious attention as antiviral and anticancer agents and drug delivery carriers as well. A large number of such fullerene С60 derivatives obtained to date. However, there is an obvious deficit of information about causes and mechanisms of immediately and long-term consequences of their effects in vivo which is a true obstacle on the way leading to practical medical use of them. First, this concerns their impact on the proliferation, apoptosis and necrosis regulation. Fullerene nanoparticle functionalization type, their sizes and surface nanopathology are of great importance to further promoting of either cytoprotective or cytotoxic effects. This lecture provides modern concept analysis regarding fullerenes effects on apoptosis pathway in normal and tumor cells.
Anisotropic 'hairs' in string cosmology
Kunze, Kerstin E.; Durrer, Ruth
1999-01-01
In this letter we investigate whether the isotropy problem is naturally solved in inflationary cosmologies inspired by string theory, so called pre-big-bang cosmologies. We find that, in contrast to what happens in the more common 'potential inflation' models, initial anisotropies do not decay during pre-big-bang inflation.
Mitochondrial dynamics and apoptosis
Suen, Der-Fen; Norris, Kristi L.; Youle, Richard J.
2008-01-01
In healthy cells, mitochondria continually divide and fuse to form a dynamic interconnecting network. The molecular machinery that mediates this organelle fission and fusion is necessary to maintain mitochondrial integrity, perhaps by facilitating DNA or protein quality control. This network disintegrates during apoptosis at the time of cytochrome c release and prior to caspase activation, yielding more numerous and smaller mitochondria. Recent work shows that proteins involved in mitochondri...
Apoptosis: una muerte silenciosa
Directory of Open Access Journals (Sweden)
Isis Casadelvalle Pérez
2006-01-01
Full Text Available La apoptosis o muerte celular programada es un tipo de muerte presente en todas las células eucarióticas. Es un proceso ordenado y esencial del desarrollo normal y de mantenimiento de la homeostasis de un organismo. En el presente trabajo se resumen las principales características fisiológicas, bioquímicas y moleculares de la muerte por apoptosis, evento que ocurre de forma apagada o silenciosa, o sea, sin daño celular aparente diferenciándose claramente del proceso de necrosis celular. En ese proceso se destaca la mitocondria, como organelo celular donde mediado por la activación de las caspasas se inicia el paso hacia la muerte celular programada. En el momento actual, la apoptosis ha cobrado un verdadero valor para la mejor comprensión de los procesos biológicos normales en los que este evento está involucrado y que con anterioridad no era tomado en cuenta. En este sentido, se comentan las principales técnicas de detección de muerte celular programada y se aclara que la elección de algunas de ellas depende del modelo de estudio. Tambi én se dan a conocer algunas de las patologías generales en las que este proceso representa un papel determinante y se discute acerca de cómo algunas alteraciones en los mecanismos de regulación de la apoptosis inducen la aparici ón de varias enfermedades, incluyendo aquellos desórdenes en los que ocurre acumulación celular (cáncer, alteración cardiaca, neurodegeneración y SIDA. El estudio y caracterización de este complejo mecanismo ha cambiado profundamente la comprensión de numerosas patologías en los organismos eucariotas.
Derivation of anisotropic dissipative fluid dynamics from the Boltzmann equation
Molnar, E; Rischke, D H
2016-01-01
Fluid-dynamical equations of motion can be derived from the Boltzmann equation in terms of an expansion around a single-particle distribution function which is in local thermodynamical equilibrium, i.e., isotropic in momentum space in the rest frame of a fluid element. To zeroth order this expansion yields ideal fluid dynamics, to first order Navier-Stokes theory, and to second order transient theories of dissipative fluid dynamics. However, in situations where the single-particle distribution function is highly anisotropic in momentum space, such as the initial stage of heavy-ion collisions at relativistic energies, such an expansion is bound to break down. Nevertheless, one can still derive a fluid-dynamical theory, so-called anisotropic fluid dynamics, in terms of an expansion around a single-particle distribution function which incorporates (at least parts of) the momentum anisotropy via a suitable parametrization. In this paper we derive, up to terms of second order in this expansion, the equations of mo...
Image Segmentation With Eigenfunctions of an Anisotropic Diffusion Operator.
Wang, Jingyue; Huang, Weizhang
2016-05-01
We propose the eigenvalue problem of an anisotropic diffusion operator for image segmentation. The diffusion matrix is defined based on the input image. The eigenfunctions and the projection of the input image in some eigenspace capture key features of the input image. An important property of the model is that for many input images, the first few eigenfunctions are close to being piecewise constant, which makes them useful as the basis for a variety of applications, such as image segmentation and edge detection. The eigenvalue problem is shown to be related to the algebraic eigenvalue problems resulting from several commonly used discrete spectral clustering models. The relation provides a better understanding and helps developing more efficient numerical implementation and rigorous numerical analysis for discrete spectral segmentation methods. The new continuous model is also different from energy-minimization methods such as active contour models in that no initial guess is required for in the current model. A numerical implementation based on a finite-element method with an anisotropic mesh adaptation strategy is presented. It is shown that the numerical scheme gives much more accurate results on eigenfunctions than uniform meshes. Several interesting features of the model are examined in numerical examples, and possible applications are discussed. PMID:26992021
Albedo and constant source problems for extremely anisotropic scattering
International Nuclear Information System (INIS)
The half-space albedo problem and the constant source problem have been solved for a combination of the linearly anisotropic scattering and Inoenue's scattering functions. The linear transport equation for extremely anisotropic scattering kernel can be converted into an equivalent equation with a linearly anisotropic scattering kernel and the modified FN method can be used for albedo calculations. (orig.)
Nucleation in suspensions of anisotropic colloids
Schilling, T.; Frenkel, D.
2005-01-01
We report Monte Carlo studies of liquid crystal nucleation in two types of anisotropic colloidal systems: hard rods and hard ellipsoids. In both cases we find that nucleation pathways differ strongly from the pathways in systems of spherical particles. Short hard rods show an effect of self-poisonin
Spin Wave Theory of Strongly Anisotropic Magnets
DEFF Research Database (Denmark)
Lindgård, Per-Anker
1977-01-01
A strong anisotropy gives rise to a non-spherical precession of the spins with different amplitudes in the x and y directions. The highly anharmonic exchange interaction thereby becomes effectively anisotropic. The possibility of detecting a genuine two-ion anisotropy is discussed, and comments are...
Silicon as an anisotropic mechanical material
DEFF Research Database (Denmark)
Thomsen, Erik Vilain; Reck, Kasper; Skands, Gustav Erik;
2014-01-01
While silicon is an anisotropic material it is often in literature treated as an isotropic material when it comes to plate calculations. This leads to considerable errors in the calculated deflection. To overcome this problem, we present an in-depth analysis of the bending behavior of thin...
A generalized anisotropic deformation formulation for geomaterials
Lei, Z.; Rougier, Esteban; Knight, E. E.; Munjiza, A.; Viswanathan, H.
2016-04-01
In this paper, the combined finite-discrete element method (FDEM) has been applied to analyze the deformation of anisotropic geomaterials. In the most general case geomaterials are both non-homogeneous and non-isotropic. With the aim of addressing anisotropic material problems, improved 2D FDEM formulations have been developed. These formulations feature the unified hypo-hyper elastic approach combined with a multiplicative decomposition-based selective integration for volumetric and shear deformation modes. This approach is significantly different from the co-rotational formulations typically encountered in finite element codes. Unlike the co-rotational formulation, the multiplicative decomposition-based formulation naturally decomposes deformation into translation, rotation, plastic stretches, elastic stretches, volumetric stretches, shear stretches, etc. This approach can be implemented for a whole family of finite elements from solids to shells and membranes. This novel 2D FDEM based material formulation was designed in such a way that the anisotropic properties of the solid can be specified in a cell by cell basis, therefore enabling the user to seed these anisotropic properties following any type of spatial variation, for example, following a curvilinear path. In addition, due to the selective integration, there are no problems with volumetric or shear locking with any type of finite element employed.
Institute of Scientific and Technical Information of China (English)
Vagif S. GULIYEV; Rza Ch. MUSTAFAYEV
2011-01-01
In this paper we give the conditions on the pair (ω1,ω2) which ensures the boundedness of the anisotropic maximal operator and anisotropic singular integral operators from one generalized Morrey space Mp,ω1 to another Mp,ω2,1 ＜ p ＜ oo,and from the space M1,ω1 to the weak space W M1,ω2.
3-D Isotropic and Anisotropic S-velocity Structure in the North American Upper Mantle
Yuan, H.; Marone, F.; Romanowicz, B.; Abt, D.; Fischer, K.
2008-12-01
The tectonic diversity of the North American continent has led to a number of geological, tectonic and geodynamical models, many of which can be better tested with high resolution 3-d tomographic models of the isotropic and anisotropic mantle structure of the continent. In the framework of non-linear asymptotic coupling theory (NACT), we recently developed tools to invert long period seismic waveforms combined with SKS splitting data, for both isotropic and radial and azimuthal anisotropic S-wave velocity structure in the upper mantle at the continental scale (Marone et al., 2007; Marone and Romanowicz, 2007). Striking differences in both isotropic and anisotropic velocity structure were observed: beneath the high velocity stable cratonic region a distinct two-layer anisotropic domain is present, with the bottom layer fast axis direction aligned with the absolute plate motion, and a shallower lithospheric layer with north pointing fast axis most likely showing records of past tectonic history; under the active western US the direction of tomographically inferred anisotropy is stable with depth and compatible with the absolute plate motion direction. Here we present an updated model which includes nearly five more years of data, including data from newly operative USArray stations, and a somewhat more extended frequency band. Our new model confirms our previous results, and reveals greater yet complex details of the anisotropic velocity structure beneath the western U.S.. We also show initial results of incorporating constraints on the depth to the lithosphere-asthenosphere boundary (LAB) using teleseismic receiver functions. We discuss the different anisotropic domains resolved both laterally and in depth, in the context of tectonic history of the north American continent.
Directory of Open Access Journals (Sweden)
Richard R. Meehan
2011-04-01
Full Text Available Epigenetic mechanisms assist in maintaining gene expression patterns and cellular properties in developing and adult tissues. The molecular pathology of disease states frequently includes perturbation of DNA and histone methylation patterns, which can activate apoptotic pathways associated with maintenance of genome integrity. This perspective focuses on the pathways linking DNA methyltransferases and methyl-CpG binding proteins to apoptosis, and includes new bioinformatic analyses to characterize the evolutionary origin of two G/T mismatch-specific thymine DNA glycosylases, MBD4 and TDG.
Jet quenching effects on the anisotropic flow at RHIC
Energy Technology Data Exchange (ETDEWEB)
Andrade, R.P.G. [Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Santo André, SP, 09210-170 (Brazil); Noronha, J. [Instituto de Física, Universidade de São Paulo, C.P. 66318, 05315-970 São Paulo, SP (Brazil); Denicol, Gabriel S. [Department of Physics, McGill University, 3600 University Street, Montreal, Quebec, H3A 2T8 (Canada)
2014-12-15
In this article we investigate how the energy and momentum deposited by partonic dijets in the quark–gluon plasma may perturb the geometry-induced hydrodynamic expansion of the bulk nuclear matter created in heavy ion collisions at the RHIC. The coupling between the jets and the medium is done through a source term in the energy–momentum conservation equations for ideal hydrodynamics. We concentrate our attention at mid-rapidity and solve the equations event-by-event imposing boost-invariance. For p{sub T}≳1 GeV the anisotropic flow is found to be considerably enhanced, if the dijets deposit on average more than 12 GeV in the medium (or equivalently 6 GeV for each jet of the pair), which corresponds, in our model, to an average suppression greater than 65% of the initial jet transverse energy.
Jet quenching effects on the anisotropic flow at RHIC
International Nuclear Information System (INIS)
In this article we investigate how the energy and momentum deposited by partonic dijets in the quark–gluon plasma may perturb the geometry-induced hydrodynamic expansion of the bulk nuclear matter created in heavy ion collisions at the RHIC. The coupling between the jets and the medium is done through a source term in the energy–momentum conservation equations for ideal hydrodynamics. We concentrate our attention at mid-rapidity and solve the equations event-by-event imposing boost-invariance. For pT≳1 GeV the anisotropic flow is found to be considerably enhanced, if the dijets deposit on average more than 12 GeV in the medium (or equivalently 6 GeV for each jet of the pair), which corresponds, in our model, to an average suppression greater than 65% of the initial jet transverse energy
Photothermal method for absorption measurements in anisotropic crystals
Stubenvoll, M.; Schäfer, B.; Mann, K.; Novak, O.
2016-02-01
A measurement system for quantitative determination of both surface and bulk contributions to the photo-thermal absorption has been extended to anisotropic optical media. It bases upon a highly sensitive Hartmann-Shack wavefront sensor, accomplishing precise on-line monitoring of wavefront deformations of a collimated test beam transmitted perpendicularly through the laser-irradiated side of a cuboid sample. Caused by the temperature dependence of the refractive index as well as thermal expansion, the initially plane wavefront of the test beam is distorted. Sign and magnitude depend on index change and expansion. By comparison with thermal theory, a calibration of the measurement is possible, yielding a quantitative absolute measure of bulk and surface absorption losses from the transient wavefront distortion. Results for KTP and BBO single crystals are presented.
Nuclear modification factor in an anisotropic quark-gluon plasma
Mandal, Mahatsab; Bhattacharya, Lusaka; Roy, Pradip
2011-10-01
We calculate the nuclear modification factor (RAA) of light hadrons by taking into account the initial state momentum anisotropy of the quark-gluon plasma (QGP) expected to be formed in relativistic heavy ion collisions. Such an anisotropy can result from the initial rapid longitudinal expansion of the matter. A phenomenological model for the space-time evolution of the anisotropic QGP is used to obtain the time dependence of the anisotropy parameter ξ and the hard momentum scale, phard. The result is then compared with the PHENIX experimental data to constrain the isotropization time scale, τiso for fixed initial conditions (FIC). It is shown that the extracted value of τiso lies in the range 0.5⩽τiso⩽1.5. However, using a fixed final multiplicity (FFM) condition does not lead to any firm conclusion about the extraction of the isotropization time. The present calculation is also extended to contrast with the recent measurement of nuclear modification factor by the ALICE collaboration at s=2.76 TeV. It is argued that in the present approach, the extraction of τiso at this energy is uncertain and, therefore, refinement of the model is necessary. The sensitivity of the results on the initial conditions has been discussed. We also present the nuclear modification factor at Large Hadron Collider (LHC) energies with s=5.5 TeV.
Apoptosis Resistance in Endometriosis
Directory of Open Access Journals (Sweden)
Liselotte Mettler
2011-08-01
Full Text Available Introduction: In a cytological analysis of endometriotic lesions neither granulocytes nor cytotoxic T-cells appear in an appreciable number. Based on this observation we aimed to know, whether programmed cell death plays an essential role in the destruction of dystopic endometrium. Disturbances of the physiological mechanisms of apoptosis, a persistence of endometrial tissue could explain the disease. Another aspect of this consideration is the proliferation competence of the dystopic mucous membrane. Methods: Endometriotic lesions of 15 patients were examined through a combined measurement of apoptosis activity with the TUNEL technique (terminal deoxyribosyltransferase mediated dUTP Nick End Labeling and the proliferation activity (with the help of the Ki-67-Antigens using the monoclonal antibody Ki-S5. Results: Twelve out of 15 women studied showed a positive apoptotic activity of 3-47% with a proliferation activity of 2-25% of epithelial cells. Therefore we concluded that the persistence of dystopic endometrium requires proliferative epithelial cells from middle to lower endometrial layers. Conclusion: A dystopia misalignment of the epithelia of the upper layers of the functionalism can be rapidly eliminated by apoptotic procedures.
Effect of pH on radiation-induced apoptosis
International Nuclear Information System (INIS)
Purpose/Objective: The effect of environmental pH on the radiation-induced apoptosis in tumor cells in vitro was investigated. Materials and Methods: SCK mammary adenocarcinoma cells of A/J mice were irradiated with γ-rays using a 137Cs irradiator and incubated in media of different pHs. After incubation at 37 degree sign C for 24-120 hrs., the extent of apoptosis was determined using agarose gel electrophoresis of DNA, in situ TUNEL staining, flow cytometry, and release of 3H from 3H-thymidine labeled cells. The membrane integrity, using the trypan blue exclusion method, and the clonogenicity of the cells were also determined. Results: Irradiation with 2-12 Gy of γ-rays induced apoptosis in pH 7.5 medium within 48 hrs. The radiation-induced apoptosis progressively declined as the medium pH was lowered so that little apoptosis occurred in 48 hrs. after irradiation with 12 Gy in pH 6.6 medium. However, when the cells were irradiated and incubated for 48 hrs. in pH 6.6 medium and then medium was replaced with pH 7.5 medium, apoptosis promptly occurred. Apoptosis also occurred even in pH 6.6 medium when the cells were irradiated and maintained in pH 7.5 medium for 8 hrs. or longer post-irradiation before incubation in pH 6.6 medium. Conclusion: An acidic environment markedly suppresses radiation-induced apoptosis probably by suppressing the expression of initial signals responsible for irradiation-induced apoptosis. Indications are that the signals persist in an acidic environment and trigger apoptosis when the environmental acidity is eased. Our results suggest that the acidic environment in human tumors may inhibit the apoptosis after irradiation. However, apoptosis may be triggered when reoxygenation occurs after irradiation, and thus, the intratumor environment becomes less acidic after irradiation. Not only the change in pO2 but the change in pH during the course of fractionated radiotherapy may greatly influence the outcome of the treatment
Apoptosis : Target of cancer therapy
Ferreira, CG; Epping, M; Kruyt, FAE; Giaccone, G
2002-01-01
Recent knowledge on apoptosis has made it possible to devise novel approaches, which exploit this process to treat cancer. In this review, we discuss in detail approaches to induce tumor cell apoptosis, their mechanism of action, stage of development, and possible drawbacks. Finally, the obstacles y
Cardiovascular molecular imaging of apoptosis
Energy Technology Data Exchange (ETDEWEB)
Wolters, S.L.; Reutelingsperger, C.P.M. [Maastricht University, Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht (Netherlands); Corsten, M.F.; Hofstra, L. [Maastricht University, Department of Cardiology, Cardiovascular Research Institute Maastricht, P.O. Box 616, Maastricht (Netherlands); Narula, J. [University of California Irvine, Department of Cardiology, Irvine (United States)
2007-06-15
Molecular imaging strives to visualise processes at the molecular and cellular level in vivo. Understanding these processes supports diagnosis and evaluation of therapeutic efficacy on an individual basis and thereby makes personalised medicine possible. Apoptosis is a well-organised mode of cell suicide that plays a role in cardiovascular diseases (CVD). Apoptosis is associated with loss of cardiomyocytes following myocardial infarction, atherosclerotic plaque instability, congestive heart failure and allograft rejection of the transplanted heart. Thus, apoptosis constitutes an attractive target for molecular imaging of CVD. Our current knowledge about the molecular players and mechanisms underlying apoptosis offers a rich palette of potential molecular targets for molecular imaging. However, only a few have been successfully developed so far. This review highlights aspects of the molecular machinery and biochemistry of apoptosis relevant to the development of molecular imaging probes. It surveys the role of apoptosis in four major areas of CVD and portrays the importance and future perspectives of apoptosis imaging. The annexin A5 imaging protocol is emphasised since it is the most advanced protocol to measure apoptosis in both preclinical and clinical studies. (orig.)
Nuclear Apoptosis Contributes to Sarcopenia
Alway, Stephen E.; Parco M. Siu
2008-01-01
Apoptosis results in DNA fragmentation and, subsequently, destruction of cells containing a single nucleus. Our hypothesis is that multinucleated cells such as muscle fibers can experience apoptotic-induced loss of single nuclei (nuclear apoptosis) without destruction of the entire fiber. The loss of nuclei likely contributes to atrophy and sarcopenia. Furthermore, increased chronic activity attenuates apoptotic signaling, which may reduce sarcopenia.
Bond diluted anisotropic quantum Heisenberg model
International Nuclear Information System (INIS)
Effects of the bond dilution on the critical temperatures, phase diagrams and the magnetization behaviors of the isotropic and anisotropic quantum Heisenberg model have been investigated in detail. For the isotropic case, bond percolation threshold values have been determined for several numbers of two (2D) and three (3D) dimensional lattices. In order to investigate the effect of the anisotropy in the exchange interaction on the results obtained for the isotropic model, a detailed investigation has been made on a honeycomb lattice. Some interesting results, such as second order reentrant phenomena in the phase diagrams have been found. - Highlights: • Anisotropic quantum Heisenberg model with bond dilution investigated. • Bond percolation threshold values given for 2D and 3D lattices in isotropic case. • Phase diagrams and ground state magnetizations investigated in detail. • Variation of the bond percolation threshold values with anisotropy determined
Anisotropic hydrodynamics for conformal Gubser flow
Strickland, Michael; Ryblewski, Radoslaw
2015-01-01
In this proceedings contribution, we review the exact solution of the anisotropic hydrodynamics equations for a system subject to Gubser flow. For this purpose, we use the leading-order anisotropic hydrodynamics equations which assume that the distribution function is ellipsoidally symmetric in local-rest-frame momentum. We then prove that the SO(3)_q symmetry in de Sitter space constrains the anisotropy tensor to be of spheroidal form with only one independent anisotropy parameter remaining. As a consequence, the exact solution reduces to the problem of solving two coupled non-linear differential equations. We show that, in the limit that the relaxation time goes to zero, one obtains Gubser's ideal hydrodynamic solution and, in the limit that the relaxation time goes to infinity, one obtains the exact free streaming solution obtained originally by Denicol et al. For finite relaxation time, we solve the equations numerically and compare to the exact solution of the relaxation-time-approximation Boltzmann equa...
Rainbow metric from quantum gravity: anisotropic cosmology
Assanioussi, Mehdi
2016-01-01
In this paper we present a construction of effective cosmological models which describe the propagation of a massive quantum scalar field on a quantum anisotropic cosmological spacetime. Each obtained effective model is represented by a rainbow metric in which particles of distinct momenta propagate on different classical geometries. Our analysis shows that upon certain assumptions and conditions on the parameters determining such anisotropic models, we surprisingly obtain a unique deformation parameter $\\beta$ in the modified dispersion relation of the modes. Hence inducing an isotropic deformation despite the general starting considerations. We then ensure the recovery of the dispersion relation realized in the isotropic case, studied in [arXiv:1412.6000], when some proper symmetry constraints are imposed, and we estimate the value of the deformation parameter for this case in loop quantum cosmology context.
Anisotropic fluid from nonlocal tidal effects
Culetu, Hristu
2014-01-01
The Shiromizu et al. \\cite{SMS} covariant decomposition formalism is used to find out the brane properties rooted from the 5-dimensional Witten bubble spacetime. The non-local tensor $E_{ab}$ generated by the 5-dimensional Weyl tensor gives rise at an anisotropic energy-momentum tensor on the brane with negative energy density and $p = \\rho/3$ as equation of state. The tidal acceleration is towards the brane and that is in accordance with the negative energy density on the brane. The anisotropic fluid has vanishing "bulk" viscosity but the shear viscosity coefficient is $r$- and $t$- dependent. The brane is endowed with an apparent horizon which is exactly the radial null geodesic.
Anisotropic silica mesostructures for DNA encapsulation
Indian Academy of Sciences (India)
Aparna Ganguly; Ashok K Ganguli
2013-04-01
The encapsulation of biomolecules in inert meso or nanostructures is an important step towards controlling drug delivery agents. Mesoporous silica nanoparticles (MSN) are of immense importance owing to their high surface area, large pore size, uniform particle size and chemical inertness. Reverse micellar method with CTAB as the surfactant has been used to synthesize anisotropic mesoporous silica materials. We have used the anisotropic silica nanostructures for DNA encapsulation studies and observed a loading capacity of ∼8 g mg-1 of the sample. On functionalizing the pores of silica with amine group, the amount of DNA loaded on the rods decreases which is due to a reduction in the pore size upon grafting of amine groups.
Anisotropic Long-Range Spin Systems
Defenu, Nicolò; Ruffo, Stefano
2016-01-01
We consider anisotropic long-range interacting spin systems in $d$ dimensions. The interaction between the spins decays with the distance as a power law with different exponents in different directions: we consider an exponent $d_{1}+\\sigma_1$ in $d_1$ directions and another exponent $d_{2}+\\sigma_2$ in the remaining $d_2\\equiv d-d_1$ ones. We introduce a low energy effective action with non analytic power of the momenta. As a function of the two exponents $\\sigma_1$ and $\\sigma_2$ we show the system to have three different regimes, two where it is actually anisotropic and one where the isotropy is finally restored. We determine the phase diagram and provide estimates of the critical exponents as a function of the parameters of the system, in particular considering the case of one of the two $\\sigma$'s fixed and the other varying. A discussion of the physical relevance of our results is also presented.
Anisotropic cosmology in K-essence theory
International Nuclear Information System (INIS)
We use one of the simplest forms of the K-essence theory and we apply it to the classical anisotropic Bianchi type I cosmological model, with a barotropic perfect fluid (p = γρ) modeling the usual matter content and include the particular form of potential V(φ) = constant = 2Λ. The classical solutions for any γ ≠ 1 and Λ = 0 are found in closed form, using a time transformation. We also present the solution when Λ ≠ 0 including particular values in the barotropic parameter. We present the possible isotropization of the cosmological model Bianchi I using the ratio between the anisotropic parameters and the volume of the universe and show that this tend to a constant or to zero for different cases
New formulation of leading order anisotropic hydrodynamics
Tinti, Leonardo
2014-01-01
Anisotropic hydrodynamics is a reorganization of the relativistic hydrodynamics expansion, with the leading order already containing substantial momentum-space anisotropies. The latter are a cause of concern in the traditional viscous hydrodynamics, since large momentum anisotropies generated in ultrarelativistic heavy-ion collisions are not consistent with the hypothesis of small deviations from an isotropic background, i.e., from the local equilibrium distribution. We discuss the leading order of the expansion, presenting a new formulation for the (1+1)--dimensional case, namely, for the longitudinally boost invariant and cylindrically symmetric flow. This new approach is consistent with the well established framework of Israel and Stewart in the close to equilibrium limit (where we expect viscous hydrodynamics to work well). If we consider the (0+1)--dimensional case, that is, transversally homogeneous and longitudinally boost invariant flow, {the new form of anisotropic hydrodynamics leads to better agree...
Anisotropic brane gravity with a confining potential
Heydari-Fard, M
2007-01-01
We consider an anisotropic brane world with Bianchi type I and V geometries where the mechanism of confining the matter on the brane is through the use of a confining potential. The resulting equations on the anisotropic brane are modified by an extra term that may be interpreted as the x-matter, providing a possible phenomenological explanation for the accelerated expansion of the universe. We obtain the general solution of the field equations in an exact parametric form for both Bianchi type I and V space-times. In the special case of a Bianchi type I the solutions of the field equations are obtained in an exact analytic form. Finally, we study the behavior of the observationally important parameters.
Anisotropic brane gravity with a confining potential
Energy Technology Data Exchange (ETDEWEB)
Heydari-Fard, M. [Department of Physics, Shahid Beheshti University, Evin, Tehran 19839 (Iran, Islamic Republic of)]. E-mail: m-heydarifard@sbu.ac.ir; Sepangi, H.R. [Department of Physics, Shahid Beheshti University, Evin, Tehran 19839 (Iran, Islamic Republic of)]. E-mail: hr-sepangi@sbu.ac.ir
2007-05-24
We consider an anisotropic brane world with Bianchi type I and V geometries where the mechanism of confining the matter on the brane is through the use of a confining potential. The resulting equations on the anisotropic brane are modified by an extra term that may be interpreted as the x-matter, providing a possible phenomenological explanation for the accelerated expansion of the universe. We obtain the general solution of the field equations in an exact parametric form for both Bianchi type I and V space-times. In the special case of a Bianchi type I the solutions of the field equations are obtained in an exact analytic form. Finally, we study the behavior of the observationally important parameters.
Selective optical transmission in anisotropic multilayers structure
International Nuclear Information System (INIS)
We developed a Green's function method to study theoretically a single-defect photonic crystal composed of anisotropic dielectric materials. This structure can trap light of a given frequency range and filter only a certain frequency light with a very high quality. It is shown that the defect modes appear as peaks in the transmission spectrum. Their intensities and frequency positions depend on the incidence angle and the orientation of the principal axes of layers consisting of the superlattice and the layer defect. Our structure offers a great variety of possibilities for creating and controlling the number and transmitted intensities of defect modes. It can be a good candidate for realizing a selective electromagnetic filter. In addition to this filtration process, the defective anisotropic photonic crystal can be used to switch the modes when appropriate geometry is selected. (author)
Wireless energy transfer between anisotropic metamaterials shells
International Nuclear Information System (INIS)
The behavior of strongly coupled Radial Photonic Crystals shells is investigated as a potential alternative to transfer electromagnetic energy wirelessly. These sub-wavelength resonant microstructures, which are based on anisotropic metamaterials, can produce efficient coupling phenomena due to their high quality factor. A configuration of selected constitutive parameters (permittivity and permeability) is analyzed in terms of its resonant characteristics. The coupling to loss ratio between two coupled resonators is calculated as a function of distance, the maximum (in excess of 300) is obtained when the shells are separated by three times their radius. Under practical conditions an 83% of maximum power transfer has been also estimated. -- Highlights: •Anisotropic metamaterial shells exhibit high quality factors and sub-wavelength size. •Exchange of electromagnetic energy between shells with high efficiency is analyzed. •Strong coupling is supported with high wireless transfer efficiency. •End-to-end energy transfer efficiencies higher than 83% can be predicted
Caspase Family Proteases and Apoptosis
Institute of Scientific and Technical Information of China (English)
Ting-Jun FAN; Li-Hui HAN; Ri-Shan CONG; Jin LIANG
2005-01-01
Apoptosis, or programmed cell death, is an essential physiological process that plays a critical role in development and tissue homeostasis. The progress of apoptosis is regulated in an orderly way by a series of signal cascades under certain circumstances. The caspase-cascade system plays vital roles in the induction, transduction and amplification of intracellular apoptotic signals. Caspases, closely associated with apoptosis, are aspartate-specific cysteine proteases and members of the interleukin-1β-converting enzyme family. The activation and function of caspases, involved in the delicate caspase-cascade system, are regulated by various kinds of molecules, such as the inhibitor of apoptosis protein, Bcl-2 family proteins, calpain,and Ca2+. Based on the latest research, the members of the caspase family, caspase-cascade system and caspase-regulating molecules involved in apoptosis are reviewed.
Crossing Statistics of Anisotropic Stochastic Surface
Nezhadhaghighi, M Ghasemi; Yasseri, T; Allaei, S M Vaez
2015-01-01
We use crossing statistics and its generalization to determine the anisotropic direction imposed on a stochastic fields in $(2+1)$Dimension. This approach enables us to examine not only the rotational invariance of morphology but also we can determine the Gaussianity of underlying stochastic field in various dimensions. Theoretical prediction of up-crossing statistics (crossing with positive slope at a given threshold $\\alpha$ of height fluctuation), $\
Bond diluted anisotropic quantum Heisenberg model
Akıncı, Ümit
2013-01-01
Effects of the bond dilution on the critical temperatures, phase diagrams and the magnetization behaviors of the isotropic and anisotropic quantum Heisenberg model have been investigated in detail. For the isotropic case, bond percolation threshold values have been determined for several numbers of two (2D) and three (3D) dimensional lattices. In order to investigate the effect of the anisotropy in the exchange interaction on the results obtained for the isotropic model, a detailed investigat...
Analyzing and Predicting Anisotropic Effects of BRDFs
Czech Academy of Sciences Publication Activity Database
Filip, Jiří
New York: ACM, 2015, s. 25-32. ISBN 978-1-4503-3812-7. [ACM SIGGRAPH Symposium on Applied Perception. Tubingen (DE), 13.09.2015-14.09.2015] R&D Projects: GA ČR(CZ) GA14-10911S; GA ČR(CZ) GA14-02652S Institutional support: RVO:67985556 Keywords : BRDF * anisotropic * shape * illumination * measure Subject RIV: BD - Theory of Information http://library.utia.cas.cz/separaty/2015/RO/filip-0448393.pdf
Symmetry analysis for anisotropic field theories
Energy Technology Data Exchange (ETDEWEB)
Parra, Lorena; Vergara, J. David [Instituto de Ciencias Nucleares, UNAM, Circuito Exterior s/n, Ciudad Universitaria. Delg. Coyoacan. C.P. 04510 Mexico DF (Mexico)
2012-08-24
The purpose of this paper is to study with the help of Noether's theorem the symmetries of anisotropic actions for arbitrary fields which generally depend on higher order spatial derivatives, and to find the corresponding current densities and the Noether charges. We study in particular scale invariance and consider the cases of higher derivative extensions of the scalar field, electrodynamics and Chern-Simons theory.
Highly-anisotropic hydrodynamics for central collisions
Ryblewski, Radoslaw
2016-01-01
The framework of leading-order anisotropic hydrodynamics is supplemented with realistic equation of state and self-consistent freeze-out prescription. The model is applied to central proton-nucleus collisions. The results are compared to those obtained within standard Israel-Stewart second-order viscous hydrodynamics. It is shown that the resulting hadron spectra are highly-sensitive to the hydrodynamic approach that has been used.
Relativistic Bottomonium Spectrum from Anisotropic Lattices
Liao, X.; Manke, T.
2001-01-01
We report on a first relativistic calculation of the quenched bottomonium spectrum from anisotropic lattices. Using a very fine discretisation in the temporal direction we were able to go beyond the non-relativistic approximation and perform a continuum extrapolation of our results from five different lattice spacings (0.04-0.17 fm) and two anisotropies (4 and 5). We investigate several systematic errors within the quenched approximation and compare our results with those from non-relativisti...
Dynamical 3-Space: Anisotropic Brownian Motion Experiment
Cahill R. T.
2015-01-01
In 2014 Jiapei Dai reported evidence of anisotropic Brownian motion of a toluidine blue colloid solution in water. In 2015 Felix Scholkmann analysed the Dai data and detected a sidereal time dependence, indicative of a process driving the preferred Brownian mo- tion diffusion direction to a star-based preferred direction. Here we further analyse the Dai data and extract the RA and Dec of that preferred direction, and relate the data to previous determinations from NASA Spacecr...
Acoustic anisotropic wavefields through perturbation theory
Alkhalifah, Tariq Ali
2013-09-01
Solving the anisotropic acoustic wave equation numerically using finite-difference methods introduces many problems and media restriction requirements, and it rarely contributes to the ability to resolve the anisotropy parameters. Among these restrictions are the inability to handle media with η<0 and the presence of shear-wave artifacts in the solution. Both limitations do not exist in the solution of the elliptical anisotropic acoustic wave equation. Using perturbation theory in developing the solution of the anisotropic acoustic wave equation allows direct access to the desired limitation-free solutions, that is, solutions perturbed from the elliptical anisotropic background medium. It also provides a platform for parameter estimation because of the ability to isolate the wavefield dependency on the perturbed anisotropy parameters. As a result, I derive partial differential equations that relate changes in the wavefield to perturbations in the anisotropy parameters. The solutions of the perturbation equations represented the coefficients of a Taylor-series-type expansion of the wavefield as a function of the perturbed parameter, which is in this case η or the tilt of the symmetry axis. The expansion with respect to the symmetry axis allows use of an acoustic transversely isotropic media with a vertical symmetry axis (VTI) kernel to estimate the background wavefield and the corresponding perturbation coefficients. The VTI extrapolation kernel is about one-fourth the cost of the transversely isotropic model with a tilt in the symmetry axis kernel. Thus, for a small symmetry axis tilt, the cost of migration using a first-order expansion can be reduced. The effectiveness of the approach was demonstrated on the Marmousi model.
Massively parallel computation on anisotropic meshes
Digonnet, Hugues; Silva, Luisa; Coupez, Thierry
2013-01-01
In this paper, we present developments done to obtain efficient parallel computations on supercomputers up to 8192 cores. While most massively parallel computation are shown using regular grid it is less common to see massively parallel computation using anisotropic adapted unstructured meshes. We will present here two mains components done to reach very large scale calculation up to 10 billions unknowns using a muligrid method over unstructured mesh running on 8192 cores. We firstly focus on...
Mesoscopic Phase Separation in Anisotropic Superconductors
V. I. Yukalov; Yukalova, E. P.
2005-01-01
General properties of anisotropic superconductors with mesoscopic phase separation are analysed. The main conclusions are as follows: Mesoscopic phase separation can be thermodynamically stable only in the presence of repulsive Coulomb interactions. Phase separation enables the appearance of superconductivity in a heterophase sample even if it were impossible in pure-phase matter. Phase separation is crucial for the occurrence of superconductivity in bad conductors. Critical temperature for a...
Anisotropic Friedel oscillations inside the domain wall
Energy Technology Data Exchange (ETDEWEB)
Ghanbary, R. [Department of Physics, Payame Noor University, Urmia (Iran, Islamic Republic of); Phirouznia, A. [Department of Physics, Azarbaijan Shahid Madani University, 53714-161 Tabriz (Iran, Islamic Republic of); Condensed Matter Computational Research Lab. Azarbaijan Shahid Madani University, 53714-161 Tabriz (Iran, Islamic Republic of)
2015-12-01
The influence of the non-collinear magnetic configuration on Friedel oscillations is investigated theoretically. Specifically the influence of the magnetic configuration on the induced electric charge in a Néel type domain wall (DW) has been obtained. The well-known Levy and Zhang eigenstates for a linear DW have been employed. Then the dielectric function of this magnetic system has been obtained within the random phase approximation. Results of the current work demonstrate that magnetic configuration of the system manifests itself in the electric properties such as induced charge distribution. Meanwhile the anisotropy of the induced charge distribution in the real space provides a measurable way for the determination of the DW orientation. In addition anisotropy of the dielectric function in k-space arises as a result of the anisotropy of the magnetic configuration. Therefore the orientation of the magnetic DW could also be captured by full optical measurements. - Highlights: • Dielectric function of a non-collinear magnetic structure. • Anisotropic dielectric function in k-space. • Anisotropic optical absorption. • Anisotropic Friedel oscillations in non-collinear magnetic structures.
Anisotropic cosmological solutions in massive vector theories
Heisenberg, Lavinia; Tsujikawa, Shinji
2016-01-01
In beyond-generalized Proca theories including the extension to theories higher than second order, we study the role of a spatial component $v$ of a massive vector field on the anisotropic cosmological background. We show that, as in the case of the isotropic cosmological background, there is no additional ghostly degrees of freedom associated with the Ostrogradski instability. In second-order generalized Proca theories we find the existence of anisotropic solutions on which the ratio between the anisotropic expansion rate $\\Sigma$ and the isotropic expansion rate $H$ remains nearly constant in the radiation-dominated epoch. In the regime where $\\Sigma/H$ is constant, the spatial vector component $v$ works as a dark radiation with the equation of state close to $1/3$. During the matter era, the ratio $\\Sigma/H$ decreases with the decrease of $v$. As long as the conditions $|\\Sigma| \\ll H$ and $v^2 \\ll \\phi^2$ are satisfied around the onset of late-time cosmic acceleration, where $\\phi$ is the temporal vector ...
ARTc: Anisotropic reflectivity and transmissivity calculator
Malehmir, Reza; Schmitt, Douglas R.
2016-08-01
While seismic anisotropy is known to exist within the Earth's crust and even deeper, isotropic or even highly symmetric elastic anisotropic assumptions for seismic imaging is an over-simplification which may create artifacts in the image, target mis-positioning and hence flawed interpretation. In this paper, we have developed the ARTc algorithm to solve reflectivity, transmissivity as well as velocity and particle polarization in the most general case of elastic anisotropy. This algorithm is able to provide reflectivity solution from the boundary between two anisotropic slabs with arbitrary symmetry and orientation up to triclinic. To achieve this, the algorithm solves full elastic wave equation to find polarization, slowness and amplitude of all six wave-modes generated from the incident plane-wave and welded interface. In the first step to calculate the reflectivity, the algorithm solves properties of the incident wave such as particle polarization and slowness. After calculation of the direction of generated waves, the algorithm solves their respective slowness and particle polarization. With this information, the algorithm then solves a system of equations incorporating the imposed boundary conditions to arrive at the scattered wave amplitudes, and thus reflectivity and transmissivity. Reflectivity results as well as slowness and polarization are then tested in complex computational anisotropic models to ensure their accuracy and reliability. ARTc is coded in MATLAB ® and bundled with an interactive GUI and bash script to run on single or multi-processor computers.
Anisotropic Optical Properties of Layered Germanium Sulfide
Tan, Dezhi; Wang, Feijiu; Mohamed, Nur Baizura; Mouri, Shinichiro; Sandhaya, Koirala; Zhang, Wenjing; Miyauchi, Yuhei; Ohfuchi, Mari; Matsuda, Kazunari
2016-01-01
Two-dimensional (2D) layered materials, transition metal dichalcogenides and black phosphorus, have attracted much interest from the viewpoints of fundamental physics and device applications. The establishment of new functionalities in anisotropic layered 2D materials is a challenging but rewarding frontier, owing to their remarkable optical properties and prospects for new devices. Here, we report the anisotropic optical properties of layered 2D monochalcogenide of germanium sulfide (GeS). Three Raman scattering peaks corresponding to the B3g, A1g, and A2g modes with strong polarization dependence are demonstrated in the GeS flakes, which validates polarized Raman spectroscopy as an effective method for identifying the crystal orientation of anisotropic layered GeS. Photoluminescence (PL) is observed with a peak at around 1.66 eV that originates from the direct optical transition in GeS at room temperature. Moreover, determination of the polarization dependent characteristics of the PL and absorption reveals...
Tricerri, Paolo; Dedè, Luca; Deparis, Simone; Quarteroni, Alfio; Robertson, Anne M.; Sequeira, Adélia
2015-03-01
This paper considers numerical simulations of fluid-structure interaction (FSI) problems in hemodynamics for idealized geometries of healthy cerebral arteries modeled by both nonlinear isotropic and anisotropic material constitutive laws. In particular, it focuses on an anisotropic model initially proposed for cerebral arteries to characterize the activation of collagen fibers at finite strains. In the current work, this constitutive model is implemented for the first time in the context of an FSI formulation. In this framework, we investigate the influence of the material model on the numerical results and, in the case of the anisotropic laws, the importance of the collagen fibers on the overall mechanical behavior of the tissue. With this aim, we compare our numerical results by analyzing fluid dynamic indicators, vessel wall displacement, Von Mises stress, and deformations of the collagen fibers. Specifically, for an anisotropic model with collagen fiber recruitment at finite strains, we highlight the progressive activation and deactivation processes of the fibrous component of the tissue throughout the wall thickness during the cardiac cycle. The inclusion of collagen recruitment is found to have a substantial impact on the intramural stress, which will in turn impact the biological response of the intramural cells. Hence, the methodology presented here will be particularly useful for studies of mechanobiological processes in the healthy and diseased vascular wall.
Damage spreading in 2-dimensional isotropic and anisotropic Bak-Sneppen models
Bakar, Burhan; Tirnakli, Ugur
2007-01-01
We implement the damage spreading technique on 2-dimensional isotropic and anisotropic Bak-Sneppen models. Our extensive numerical simulations show that there exists a power-law sensitivity to the initial conditions at the statistically stationary state (self-organized critical state). Corresponding growth exponent $\\alpha$ for the Hamming distance and the dynamical exponent $z$ are calculated. These values allow us to observe a clear data collapse of the finite size scaling for both versions...
Blow-up properties in the parabolic problems with anisotropic nonstandard growth conditions
Liu, Bingchen; Yang, Jie
2016-03-01
In this paper, we study the parabolic problems with anisotropic nonstandard growth nonlinearities. We first give the existence and uniqueness of weak solutions in variable Sobolev spaces. Second, we use the energy methods to show the existence of blow-up solutions with negative or positive initial energy, respectively. Both the variable exponents and the coefficients make important roles in Fujita blow-up phenomena. Moreover, asymptotic properties of the blow-up solutions are determined.
Anisotropicity of Low Energy Direct Photons in Relativistic Heavy Ion Collisions
Koide, T
2016-01-01
We investigate the behavior of low energy photons radiated by deceleration processes of two colliding nuclei in relativistic heavy ion collisions, where their angular distribution reveals information of the initial geometric configurations. Such a property is reflected in the anisotropic parameter v_{2}, showing an increasing v_{2} as energy decreases, which is qualitatively different behavior from v_{2} from hadrons produced in the collisions.
Quantitative Permeability Prediction for Anisotropic Porous Media
Sheng, Q.; Thompson, K. E.
2012-12-01
Pore-scale modeling as a predictive tool has become an integral to both research and commercial simulation in recent years. Permeability is one of the most important of the many properties that can be simulated. Traditionally, permeability is determined using Darcy's law, based on the assumption that the pressure gradient is aligned with the principal flow direction. However, a wide variety of porous media exhibit anisotropic permeability due to particle orientation or laminated structure. In these types of materials, the direction of fluid flow is not aligned with the pressure gradient (except along the principal directions). Thus, it is desirable to predict the full permeability tensor for anisotropic materials using a first-principles pore-scale approach. In this work, we present a fast method to determine the full permeability tensor and the principal directions using a novel network modeling algorithm. We also test the ability of network modeling (which is an approximate method) to detect anisotropy in various structures. Both computational fluid dynamics (CFD) methods and network modeling have emerged as effective techniques to predict rock properties. CFD models are more rigorous but computationally expensive. Network modeling involves significant approximations but can be orders-of-magnitude more efficient computationally, which is important for both speed and the ability to model larger scales. This work uses network modeling, with simulations performed on two types of anisotropic materials: laminated packings (with layers of different sized particles) and oriented packings (containing particles with preferential orientation). Pore network models are created from the porous media data, and a novel method is used to determine the permeability tensor and principal flow direction using pore network modeling. The method is verified by comparing the calculated principal directions with the known anisotropy and also by comparing permeability with values from CFD
Li, Xianping
2010-01-01
Heterogeneous anisotropic diffusion problems arise in the various areas of science and engineering including plasma physics, petroleum engineering, and image processing. Standard numerical methods can produce spurious oscillations when they are used to solve those problems. A common approach to avoid this difficulty is to design a proper numerical scheme and/or a proper mesh so that the numerical solution validates the discrete counterpart (DMP) of the maximum principle satisfied by the continuous solution. A well known mesh condition for the DMP satisfaction by the linear finite element solution of isotropic diffusion problems is the non-obtuse angle condition that requires the dihedral angles of mesh elements to be non-obtuse. In this paper, a generalization of the condition, the so-called anisotropic non-obtuse angle condition, is developed for the finite element solution of heterogeneous anisotropic diffusion problems. The new condition is essentially the same as the existing one except that the dihedral ...
Enhancement of non-resonant dielectric cloaks using anisotropic composites
Takezawa, Akihiro
2014-01-01
The effectiveness of homogenized anisotropic materials in non-resonant dielectric multilayer cloaking is studied. Because existing multilayer cloaking by isotropic materials can be regarded as homogenous anisotropic cloaking from a macroscopic view, they can be efficiently designed by handling the physical properties of anisotropic materials directly. Anisotropic properties can be realized in two-phase composites if the physical properties of the material are within appropriate bounds. The optimized anisotropic physical properties are identified by a numerical optimization technique based on a full-wave simulation using the finite element method. The cloaking performance measured by the total scattering width is improved by about 10% compared with existing multilayer cloaking by isotropic materials in eight-layer cylindrical cloaking materials. The same performance with eight-layer cloaking by isotropic materials is achieved by three-layer cloaking using anisotropic materials. Cloaking with a about 50% reduct...
Testing different formulations of leading-order anisotropic hydrodynamics
Tinti, Leonardo; Florkowski, Wojciech; Strickland, Michael
2015-01-01
A recently obtained set of the equations for leading-order (3+1)D anisotropic hydrodynamics is tested against exact solutions of the Boltzmann equation with the collisional kernel treated in the relaxation time approximation. In order to perform the detailed comparisons, the new anisotropic hydrodynamics equations are reduced to the boost-invariant and transversally homogeneous case. The agreement with the exact solutions found using the new anisotropic hydrodynamics equations is similar to that found using previous, less general, formulations of anisotropic hydrodynamics. In addition, we find that, when compared to a state-of-the-art second-order viscous hydrodynamics framework, leading-order anisotropic hydrodynamics better reproduces the exact solution for the pressure anisotropy and gives comparable results for the bulk pressure evolution. Finally, we compare the transport coefficients obtained using linearized anisotropic hydrodynamics with results obtained using second-order viscous hydrodynamics.
Testing different formulations of leading-order anisotropic hydrodynamics
Tinti, Leonardo; Ryblewski, Radoslaw; Florkowski, Wojciech; Strickland, Michael
2016-02-01
A recently obtained set of the equations for leading-order (3+1)D anisotropic hydrodynamics is tested against exact solutions of the Boltzmann equation with the collisional kernel treated in the relaxation time approximation. In order to perform detailed comparisons, the new anisotropic hydrodynamics equations are reduced to the boost-invariant and transversally homogeneous case. The agreement with the exact solutions found using the new anisotropic hydrodynamics equations is similar to that found using previous, less general formulations of anisotropic hydrodynamics. In addition, we find that, when compared to a state-of-the-art second-order viscous hydrodynamics framework, leading-order anisotropic hydrodynamics better reproduces the exact solution for the pressure anisotropy and gives comparable results for the bulk pressure evolution. Finally, we compare the transport coefficients obtained using linearized anisotropic hydrodynamics with results obtained using second-order viscous hydrodynamics.
Fronts of Stress Wave in Anisotropic Piezoelectric Media
Institute of Scientific and Technical Information of China (English)
刘颖; 刘凯欣; 高凌天
2004-01-01
The characteristic of wave fronts in anisotropic piezoelectric media is analysed by adopting the generalized characteristic theory. Analytical expressions for wave velocities and wave fronts are formulated. Apart from the ordinary characteristics, a new phenomenon, energy velocity funnel, is formed on the wave fronts of quasitransverse waves in anisotropic piezoelectric materials. A three-dimensional representation of wave fronts in anisotropic piezoelectric materials is given for a better understanding of the new phenomena.
Probing the anisotropic expansion history of the universe using CMBR
International Nuclear Information System (INIS)
We have proposed a technique to detect any anisotropic expansion in the universe from the beginning of inflation to the last scattering. Any anisotropic expansion in the universe would deform the shape of the primordial density perturbations in the universe, and a shape analysis of the super-horizon fluctuations in CMBR will detect this shape deformation. Using this analysis, we have constrainted any anisotropic expansion in the universe to be less than 35%
Testing different formulations of leading-order anisotropic hydrodynamics
Tinti, Leonardo; Ryblewski, Radoslaw; Florkowski, Wojciech; Strickland, Michael
2015-01-01
A recently obtained set of the equations for leading-order (3+1)D anisotropic hydrodynamics is tested against exact solutions of the Boltzmann equation with the collisional kernel treated in the relaxation time approximation. In order to perform the detailed comparisons, the new anisotropic hydrodynamics equations are reduced to the boost-invariant and transversally homogeneous case. The agreement with the exact solutions found using the new anisotropic hydrodynamics equations is similar to t...
Relativistic modelling of stable anisotropic super-dense star
Maurya, S K; Jasim, M K
2015-01-01
In the present article we have obtained new set of exact solutions of Einstein field equations for anisotropic fluid spheres by using the Herrera et al.[1] algorithm. The anisotropic fluid spheres so obtained join continuously to Schwarzschild exterior solution across the pressure free boundary.It is observed that most of the new anisotropic solutions are well behaved and utilized to construct the super-dense star models such as neutron star and pulsars.
APOPTOSIS IN WHOLE MOUSE OVARIES
Apoptosis in Whole Mouse Ovaries Robert M. Zucker Susan C. Jeffay and Sally D. Perreault Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, 27711.
Self-organized motion in anisotropic swarms
Institute of Scientific and Technical Information of China (English)
Tianguang CHU; Long WANG; Tongwen CHEN
2003-01-01
This paper considers an anisotropic swarm model with a class of attraction and repulsion functions. It is shown that the members of the swarm will aggregate and eventually form a cohesive cluster of finite size around the swarm center. Moreover,It is also proved that under certain conditions, the swarm system can be completely stable, i. e., every solution converges to the equilibrium points of the system. The model and results of this paper extend a recent work on isotropic swarms to more general cases and provide further insight into the effect of the interaction pattern on self-organized motion in a swarm system.
BRDF Slices: Accurate Adaptive Anisotropic Appearance Acquisition
Czech Academy of Sciences Publication Activity Database
Filip, Jiří; Vávra, Radomír; Haindl, Michal; Žid, Pavel; Krupička, Mikuláš; Havran, V.
New York: IEEE Computer Society Conference Publishing Services, 2013, s. 1468-1473. ISBN 978-0-7695-4990-3. ISSN 2160-7508. [Computer Vision and Pattern Recognition. Portland, OR (US), 23.06.2013-28.06.2013] R&D Projects: GA ČR GAP103/11/0335 Grant ostatní: EC FP7, European Reintegration Grant(BE) 239294 Institutional support: RVO:67985556 Keywords : BRDF slices * adaptive anisotropic material appearance * measurement device Subject RIV: BD - Theory of Information http://library.utia.cas.cz/separaty/2013/RO/filip-0393865.pdf
Some analytical models of anisotropic strange stars
Murad, Mohammad Hassan
2016-01-01
Over the years of the concept of local isotropy has become a too stringent condition in modeling relativistic self-gravitating objects. Taking local anisotropy into consideration, in this work, some analytical models of relativistic anisotropic charged strange stars have been developed. The Einstein-Maxwell gravitational field equations have been solved with a particular form of one of the metric potentials. The radial pressure and the energy density have been assumed to follow the usual linear equation of state of strange quark matter, the MIT bag model.
Gauge Field Optics with Anisotropic Media
Liu, Fu
2014-01-01
By considering gauge transformations on the macroscopic Maxwell's equations, a two dimensional gauge field, with its pseudo magnetic field in the real space, is identified as tilted anisotropy in the constitutive parameters. We show that optical spin Hall effect and one-way edge states become possible simply by using anisotropic media with broadband response. The proposed gauge field also allows us to design an optical isolator based on the Aharonov-Bohm effect. Our approach will be useful in spoof magneto-optics with arbitrary magnetic fields mimicked by metamaterials with subwavelength unit cells. It also serves as a generic way to design polarization-dependent devices.
Theory of Random Anisotropic Magnetic Alloys
DEFF Research Database (Denmark)
Lindgård, Per-Anker
1976-01-01
A mean-field-crystal-field theory is developed for random, multicomponent, anisotropic magnetic alloys. It is specially applicable to rare-earth alloys. A discussion is given of multicritical points and phase transitions between various states characterized by order parameters with different....... Quantitative agreement can be obtained by increasing the interaction between different alloy elements, in particular for alloys with very different axial anisotropy, e.g., Tb-Tm. A model system consisting of a singlet-singlet and singlet-doublet alloy is discussed in detail. A simple procedure to include...
Anisotropic perturbations due to dark energy
Battye, R A; Battye, Richard A.; Moss, Adam
2006-01-01
A variety of observational tests seem to suggest that the universe is anisotropic. This is incompatible with the standard dogma based on adiabatic, rotationally invariant perturbations. We point out that this is a consequence of the standard decomposition of the stress-energy tensor for the cosmological fluids, and that rotational invariance need not be assumed, if there is elastic rigidity in the dark energy. The dark energy required to achieve this might be provided by point symmetric domain wall network with $P/\\rho=-2/3$, although the concept is more general. We illustrate this with reference to a model with cubic symmetry and discuss various aspects of the model.
Anisotropic flow in striped superhydrophobic channels
Zhou, Jiajia; Schmid, Friederike; Vinogradova, Olga I
2012-01-01
We report results of dissipative particle dynamics simulations and develop a semi-analytical theory and of an anisotropic flow in a parallel-plate channel with two superhydrophobic striped walls. Our approach is valid for any local slip at the gas sectors and an arbitrary distance between the plates, ranging from a thick to a thin channel. It allows us to optimize area fractions, slip lengths, channel thickness and texture orientation to maximize a transverse flow. Our results may be useful for extracting effective slip tensors from global measurements, such as the permeability of a channel, in experiments or simulations, and may also find applications in passive microfluidic mixing.
Generalized model for anisotropic compact stars
Maurya, S K; Ray, Saibal; Deb, Debabrata
2016-01-01
In the present investigation an exact generalized model for anisotropic compact stars of embedding class one is sought for under general relativistic background. The generic solutions are verified by exploring different physical aspects, viz. energy conditions, mass-radius relation, stability of the models, in connection to their validity. It is observed that the model present here for compact stars is compatible with all these physical tests and thus physically acceptable as far as the compact star candidates $RXJ~1856-37$, $SAX~J~1808.4-3658~(SS1)$ and $SAX~J~1808.4-3658~(SS2)$ are concerned.
On Radiative Fluids in Anisotropic Spacetimes
Shogin, Dmitry
2016-01-01
We apply the second-order Israel-Stewart theory of relativistic fluid- and thermodynamics to a physically realistic model of a radiative fluid in a simple anisotropic cosmological background. We investigate the asymptotic future of the resulting cosmological model and review the role of the dissipative phenomena in the early Universe. We demonstrate that the transport properties of the fluid alone, if described appropriately, do not explain the presently observed accelerated expansion of the Universe. Also, we show that, in constrast to the mathematical fluid models widely used before, the radiative fluid does approach local thermal equilibrium at late times, although very slowly, due to the cosmological expansion.
A transitioning universe with anisotropic dark energy
Yadav, Anil Kumar
2016-08-01
In this paper, we present a model of transitioning universe with minimal interaction between perfect fluid and anisotropic dark energy in Bianchi I space-time. The two sources are assumed to minimally interacted and therefore their energy momentum tensors are conserved separately. The explicit expression for average scale factor are considered in hybrid form that gives time varying deceleration parameter which describes both the early and late time physical features of universe. We also discuss the physical and geometrical properties of the model derived in this paper. The solution is interesting physically as it explain accelerating universe as well as singularity free universe.
A transitioning universe with anisotropic dark energy
Yadav, Anil Kumar
2016-01-01
In this paper, we present a model of transitioning universe with minimal interaction between perfect fluid and anisotropic dark energy in Bianchi I space-time. The two sources are assumed to minimally interacted and therefore their energy momentum tensors are conserved separately. The explicit expression for average scale factor are considered in hybrid form that gives time varying deceleration parameter which describes both the early and late time physical features of universe. We also discuss the physical and geometrical properties of the model derived in this paper. The solution is interesting physically as it explain accelerating universe as well as singularity free universe.
Wireless energy transfer between anisotropic metamaterials shells
Diaz-Rubio, Ana; Sanchez-Dehesa, Jose
2013-01-01
The behavior of strongly coupled Radial Photonic Crystals shells is investigated as a potential alternative to transfer electromagnetic energy wirelessly. These sub-wavelength resonant microstructures, which are based on anisotropic metamaterials, can produce efficient coupling phenomena due to their high quality factor. A configuration of selected constitutive parameters (permittivity and permeability) is analyzed in terms of its resonant characteristics. The coupling to loss ratio between two coupled resonators is calculated as a function of distance, the maximum (in excess of 300) is obtained when the shells are separated by three times their radius. Under practical conditions an 83% of maximum power transfer has been also estimated.
Temperature and polarization patterns in anisotropic cosmologies
International Nuclear Information System (INIS)
We study the coherent temperature and polarization patterns produced in homogeneous but anisotropic cosmological models. We show results for all Bianchi types with a Friedman-Robertson-Walker limit (i.e. Types I, V, VII0, VIIh and IX) to illustrate the range of possible behaviour. We discuss the role of spatial curvature, shear and rotation in the geodesic equations for each model and establish some basic results concerning the symmetries of the patterns produced. We also give examples of the time-evolution of these patterns in terms of the Stokes parameters I, Q and U
Conformally flat anisotropic spheres in general relativity
Herrera, L; Ospina, J F; Fuenmayor, E
2001-01-01
The condition for the vanishing of the Weyl tensor is integrated in the spherically symmetric case. Then, the resulting expression is used to find new, conformally flat, interior solutions to Einstein equations for locally anisotropic fluids. The slow evolution of these models is contrasted with the evolution of models with similar energy density or radial pressure distribution but non-vanishing Weyl tensor, thereby bringing out the different role played by the Weyl tensor, the local anisotropy of pressure and the inhomogeneity of the energy density in the collapse of relativistic spheres.
Effective Acquisition of Dense Anisotropic BRDF
Czech Academy of Sciences Publication Activity Database
Filip, Jiří; Vávra, Radomír; Havlíček, Michal
Stockholm : IEEE Computer Society, 2014, s. 2047-2052. ISBN 978-1-4799-5208-3. ISSN 1051-4651. [ICPR 2014 - The 22nd International Conference on Pattern Recognition. Stockholm (SE), 24.08.2014-28.08.2014] R&D Projects: GA ČR(CZ) GA14-10911S; GA ČR(CZ) GA14-02652S; GA ČR GAP103/11/0335 Institutional support: RVO:67985556 Keywords : BRDF * measurement * anisotropic * goniometer Subject RIV: BD - Theory of Information http://library.utia.cas.cz/separaty/2014/RO/filip-0431132.pdf
Apoptosis in cancer: therapeutic implications
Negoescu, A.
2000-01-01
This review outlines the principal limitations of the mechanisms of active cell death (ACD, apoptosis) as the basis of tumorigenesis and the rationale of almost all therapies of malignancy. The concentration of cancer therapy in the directon of ACD induction is presented as both the result of progressive understanding of the mechanisms of apoptosis and that of the favourable tumor environment for ACD signal transmission. The latter property induces the by-stand...
Invertebrate Iridovirus Modulation of Apoptosis
Institute of Scientific and Technical Information of China (English)
Trevor Williams; Nllesh S. Chitnis; Sh(a)n L. Bilimoria
2009-01-01
Programmed cell death (apoptosis) is a key host response to virus infection. Viruses that can modulate host apoptotic responses are likely to gain important opportunities for transmission. Here we review recent studies that demonstrate that particles of Invertebrate iridescent virus 6 (IIV-6) (Iridoviridae, genus Iridovirus), or an IIV-6 virion protein extract, are capable of inducing apoptosis in lepidopteran and coleopteran cells, at concentrations 1000-fold lower than that required to shut-off host macromolecular synthesis. Induction of apoptosis depends on endocytosis of one or more heat-sensitive virion component(s). Studies with a JNK inh ibitor(SP600125) indicated that the JNK signaling pathway is significantly involved in apoptosis in IIV-6 infections of Choristoneurafumiferana ceils. The genome of IIV-6 codes for an inhibitor of apoptosis iap gene (193R) that encodes a protein of 208 aa with 15% identity and 28% similarity in its amino acid sequence to IAP-3 from Cydia pomonella ganulovirus (CpGV). Transcription of IIV-6 iap did not require prior DNA or protein synthesis, indicating that it is an immediate-early class gene. Transient expression and gene knockdown studies have confirmed the functional nature of the IIV-6 iap gene. We present a tentative model for IIV-6 induction and inhibition of apoptosis in insect cells and discuss the potential applications of these findings in insect pest control.
Overlap distributions for quantum quenches in the anisotropic Heisenberg chain
Mazza, Paolo P.; Stéphan, Jean-Marie; Canovi, Elena; Alba, Vincenzo; Brockmann, Michael; Haque, Masudul
2016-01-01
The dynamics after a quantum quench is determined by the weights of the initial state in the eigenspectrum of the final Hamiltonian, i.e. by the distribution of overlaps in the energy spectrum. We present an analysis of such overlap distributions for quenches of the anisotropy parameter in the one-dimensional anisotropic spin-1/2 Heisenberg model (XXZ chain). We provide an overview of the form of the overlap distribution for quenches from various initial anisotropies to various final ones, using numerical exact diagonalization. We show that if the system is prepared in the antiferromagnetic Néel state (infinite anisotropy) and released into a non-interacting setup (zero anisotropy, XX point) only a small fraction of the final eigenstates gives contributions to the post-quench dynamics, and that these eigenstates have identical overlap magnitudes. We derive expressions for the overlaps, and present the selection rules that determine the final eigenstates having nonzero overlap. We use these results to derive concise expressions for time-dependent quantities (Loschmidt echo, longitudinal and transverse correlators) after the quench. We use perturbative analyses to understand the overlap distribution for quenches from infinite to small nonzero anisotropies, and for quenches from large to zero anisotropy.
Phenomenological aspects of an anisotropic quark-gluon plasma
International Nuclear Information System (INIS)
In this work we investigate phenomenological aspects of an anisotropic quark-gluon plasma. In the first part of this thesis, we formulate phenomenologicalmodels that take into account the momentumspace anisotropy of the system developed during the expansion of the fireball at early-times. By including the proper-time dependence of the parton hard momentum scale, phard(τ), and the plasma anisotropy parameter, ξ(τ), the proposed models allow us to interpolate from 0+1 pre-equilibrated expansion at early-times to 0+1 ideal hydrodynamics at late times. We study dilepton production as a valuable observable to experimentally determine the isotropization time of the system as well as the degree of anisotropy developed at early-times. We generalize our interpolating models to include the rapidity dependence of phard and consider its impact on forward dileptons. Next, we discuss how to constrain the onset of hydrodynamics by demanding two requirements of the solutions to the equations of motion of viscous hydrodynamics. We show this explicitly for 0+1 dimensional 2nd-order conformal viscous hydrodynamics and find that the initial conditions are non-trivially constrained. Finally, we demonstrate how to match the initial conditions for 0+1 dimensional viscous hydrodynamics from pre-equilibrated expansion. We analyze the dependence of the entropy production on the pre-equilibrium phase and discuss limitations of the standard definitions of the non-equilibrium entropy in kinetic theory. (orig.)
Phenomenological aspects of an anisotropic quark-gluon plasma
Energy Technology Data Exchange (ETDEWEB)
Martinez Guerrero, Mauricio
2010-04-30
In this work we investigate phenomenological aspects of an anisotropic quark-gluon plasma. In the first part of this thesis, we formulate phenomenologicalmodels that take into account the momentumspace anisotropy of the system developed during the expansion of the fireball at early-times. By including the proper-time dependence of the parton hard momentum scale, p{sub hard}({tau}), and the plasma anisotropy parameter, {xi}({tau}), the proposed models allow us to interpolate from 0+1 pre-equilibrated expansion at early-times to 0+1 ideal hydrodynamics at late times. We study dilepton production as a valuable observable to experimentally determine the isotropization time of the system as well as the degree of anisotropy developed at early-times. We generalize our interpolating models to include the rapidity dependence of p{sub hard} and consider its impact on forward dileptons. Next, we discuss how to constrain the onset of hydrodynamics by demanding two requirements of the solutions to the equations of motion of viscous hydrodynamics. We show this explicitly for 0+1 dimensional 2nd-order conformal viscous hydrodynamics and find that the initial conditions are non-trivially constrained. Finally, we demonstrate how to match the initial conditions for 0+1 dimensional viscous hydrodynamics from pre-equilibrated expansion. We analyze the dependence of the entropy production on the pre-equilibrium phase and discuss limitations of the standard definitions of the non-equilibrium entropy in kinetic theory. (orig.)
Aspect ratio analysis for ground states of bosons in anisotropic traps
International Nuclear Information System (INIS)
Characteristics of the initial condensate in the recent experiment on Bose-Einstein condensation (BEC) of 87Rb atoms in an anisotropic magnetic trap are discussed. Given the aspect ratio R, the quality of BEC is estimated. A simple analytical ansatz for the initial condensate wave function is proposed as a function of the aspect ratio which, in contrast to the Baym-Pethick trial wave function, can be used for any interaction strength, reproduces both the weak and the strong interaction limits, and which is in better agreement with numerical results than the latter
Study of progesterone mechanisms in radio-induced apoptosis prevention
International Nuclear Information System (INIS)
The purpose of this work was to study the modulation of radiation-induced cell death of human mammary tumoral cells by progesterone. On the one hand, we observed that progesterone protects cells against radiation-induced apoptosis and increases the proportion of surviving and proliferating damaged cells. On the other hand, a transcriptome analysis was undertaken in irradiated cells treated by progesterone, using DNA micro-arrays. This let us highlight several transcriptional dis-regulations that are likely to explain the protective effect of the hormone; in particular, we showed that progesterone regulates the expression of genes implicated in apoptosis signaling by death receptors. Knowing the crucial role of hormonal control and of apoptosis regulation in breast cancer initiation, our results may help to achieve a better understanding of the implication of progesterone in mammary carcinogenesis. (author)
Anisotropic Bianchi-I universe with phantom field and cosmological constant
Indian Academy of Sciences (India)
Bikash Chandra Paul; Dilip Paul
2008-12-01
We study an anisotropic Bianchi-I universe in the presence of a phantom field and a cosmological constant. Cosmological solutions are obtained when the kinetic energy of the phantom field is of the order of anisotropy and dominates over the potential energy of the field. The anisotropy of the universe decreases and the universe transits to an isotropic flat FRW universe accommodating the present acceleration. A class of new cosmological solutions is obtained for an anisotropic universe in case an initial anisotropy exists which is bigger than the value determined by the parameter of the kinetic part of the field. Later, an autonomous system of equations for an axially symmetric Bianchi-I universe with phantom field in an exponential potential is studied. We discuss the stability of the cosmological solutions.
International Nuclear Information System (INIS)
The behaviour of concrete, considered as isotropic for a sound material, becomes anisotropic and unilateral as soon as microcracks are initiated. Concrete also shows a different behaviour in tension than in compression. However, isotropic models, which are more simple and time costless, are still widely used for industrial applications. An anisotropic and unilateral model, with few parameters, is thus proposed in the present work, which enhances the accuracy of the description of concrete's behaviour, while remaining suitable for industrial studies. The validation of the model is based on experimental results. Numerical simulations of structures are also proposed, among which one concerns a representative volume of a confinement vessel. Finally, a non local theory is investigated to overcome the problems induced by strain localisation. (author)
BEM Analysis of Wave Propagation in a Water-Filled Borehole in an Anisotropic Solid
Institute of Scientific and Technical Information of China (English)
无
2007-01-01
This paper describes a time-domain boundary element method developed to analyze the interactions of acoustic and elastic waves near the interfaces between water and an anisotropic elastic solid. Two models are analyzed with one being the interface between two half spaces of fluid and solid and the other being a fluid region sandwiched by half space domains of anisotropic elastic solids. Both monopole and dipole point sources are used to generate an initial pressure wave in the fluid. Some snapshots of the transient wave behavior near the fluid-solid interfaces are given. The effect of the anisotropy in the solid on the pressure waveforms in the fluid is discussed. The numerical results allow detailed arrival identification and interpretation of acoustic and elastic waves propagating along the fluid-solid interfaces.
Relativistic Heavy Quark Spectrum On Anisotropic Lattices
Liao, X
2003-01-01
We report a fully relativistic quenched calculation of the heavy quark spectrum, including both charmonium and bottomonium, using anisotropic lattice QCD. We demonstrate that a fully relativistic treatment of a heavy quark system is well-suited to address the large systematic errors in non-relativistic calculations. In addition, the anisotropic lattice formulation is a very efficient framework for calculations requiring high temporal resolutions. A detailed excited charmonium spectrum is obtained, including both the exotic hybrids (with JPC = 1−+ , 0+−, 2+−) and orbitally excited mesons (with orbital angular momentum up to 3). Using three different lattice spacings (0.197, 0.131, and 0.092 fm), we perform a continuum extrapolation of the spectrum. The lowest lying exotic hybrid 1−+ lies at 4.428(41) GeV, slightly above the D**D (S + P wave) threshold of 4.287 GeV. Another two exotic hybrids 0+− and 2 +− are determined to be 4.70(17) GeV and 4.895(88)...
Anisotropic pressure and hyperons in neutron stars
International Nuclear Information System (INIS)
We study the effects of anisotropic pressure (AI-P) on properties of the neutron stars (NSs) with hyperons inside its core within the framework of extended relativistic mean field. It is found that the main effects of AI-P on NS matter is to increase the stiffness of the equation of state EOS, which compensates for the softening of the EOS due to the hyperons. The maximum mass and redshift predictions of anisotropic neutron star with hyperonic core are quite compatible with the result of recent observational constraints if we use the parameter of AI-P model h ≤ 0.8 [L. Herrera and W. Barreto, Phys. Rev. D 88 (2013) 084022.] and Λ ≤ -1.15 [D. D. Doneva and S. S. Yazadjiev, Phys. Rev. D 85 (2012) 124023.]. The radius of the corresponding NS at M = 1.4 M⊙ is more than 13 km, while the effect of AI-P on the minimum mass of NS is insignificant. Furthermore, due to the AI-P in the NS, the maximum mass limit of higher than 2.1 M⊙ cannot rule out the presence of hyperons in the NS core. (author)
Electrically Anisotropic Layered Perovskite Single Crystal
Li, Ting-You
2016-04-01
Organic-inorganic hybrid perovskites (OIHPs), which are promising materials for electronic and optoelectronic applications (1-10), have made into layered organic-inorganic hybrid perovskites (LOIHPs). These LOIHPs have been applied to thin-film transistors, solar cells and tunable wavelength phosphors (11-18). It is known that devices fabricated with single crystal exhibit the superior performance, which makes the growth of large-sized single crystals critical for future device applications (19-23). However, the difficulty in growing large-sized LOIHPs single crystal with superior electrical properties limits their practical applications. Here, we report a method to grow the centimeter-scaled LOIHP single crystal of [(HOC2H4NH3)2PbI4], demonstrating the potentials in mass production. After that, we reveal anisotropic electrical and optoelectronic properties which proved the carrier propagating along inorganic framework. The carrier mobility of in-inorganic-plane (in-plane) devices shows the average value of 45 cm2 V–1 s–1 which is about 100 times greater than the record of LOIHP devices (15), showing the importance of single crystal in device application. Moreover, the LOIHP single crystals show its ultra-short carrier lifetime of 42.7 ps and photoluminescence quantum efficiency (PLQE) of 25.4 %. We expect this report to be a start of LOIHPs for advanced applications in which the anisotropic properties are needed (24-25), and meets the demand of high-speed applications and fast-response applications.
Gravitomagnetic Instabilities in Anisotropically Expanding Fluids
Kleidis, Kostas; Kuiroukidis, Apostolos; Papadopoulos, Demetrios B.; Vlahos, Loukas
Gravitational instabilities in a magnetized Friedman-Robertson-Walker (FRW) universe, in which the magnetic field was assumed to be too weak to destroy the isotropy of the model, are known and have been studied in the past. Accordingly, it became evident that the external magnetic field disfavors the perturbations' growth, suppressing the corresponding rate by an amount proportional to its strength. However, the spatial isotropy of the FRW universe is not compatible with the presence of large-scale magnetic fields. Therefore, in this paper we use the general-relativistic version of the (linearized) perturbed magnetohydrodynamic equations with and without resistivity, to discuss a generalized Jeans criterion and the potential formation of density condensations within a class of homogeneous and anisotropically expanding, self-gravitating, magnetized fluids in curved space-time. We find that, for a wide variety of anisotropic cosmological models, gravitomagnetic instabilities can lead to subhorizontal, magnetized condensations. In the nonresistive case, the power spectrum of the unstable cosmological perturbations suggests that most of the power is concentrated on large scales (small k), very close to the horizon. On the other hand, in a resistive medium, the critical wave-numbers so obtained, exhibit a delicate dependence on resistivity, resulting in the reduction of the corresponding Jeans lengths to smaller scales (well bellow the horizon) than the nonresistive ones, while increasing the range of cosmological models which admit such an instability.
Testing anisotropic string compactifications in the lab
International Nuclear Information System (INIS)
We derive type IIB vacua which are very promising to put string theory to experimental test. These are Calabi-Yau compactifications with a 4D fibration over a 2D base. The moduli are fixed in such a way to obtain a very anisotropic configuration where the size of the 2D base is exponentially larger than the size of the 4D fibre. These provide stringy realisations of the supersymmetric large extra dimensions scenario and extensions of the ADD scenario which are characterised by TeV-scale strings and two micron-sized extra dimensions. We also study the phenomenological properties of hidden Abelian gauge bosons which mix kinetically with the ordinary photon and get a mass via the Green-Schwarz mechanism. We show that anisotropic compactifications lead naturally to dark forces for an intermediate string scale or even to a hidden CMB for the extreme case of TeV-scale strings. (Copyright copyright 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)
Finite-difference schemes for anisotropic diffusion
Energy Technology Data Exchange (ETDEWEB)
Es, Bram van, E-mail: es@cwi.nl [Centrum Wiskunde and Informatica, P.O. Box 94079, 1090GB Amsterdam (Netherlands); FOM Institute DIFFER, Dutch Institute for Fundamental Energy Research, Association EURATOM-FOM (Netherlands); Koren, Barry [Eindhoven University of Technology (Netherlands); Blank, Hugo J. de [FOM Institute DIFFER, Dutch Institute for Fundamental Energy Research, Association EURATOM-FOM (Netherlands)
2014-09-01
In fusion plasmas diffusion tensors are extremely anisotropic due to the high temperature and large magnetic field strength. This causes diffusion, heat conduction, and viscous momentum loss, to effectively be aligned with the magnetic field lines. This alignment leads to different values for the respective diffusive coefficients in the magnetic field direction and in the perpendicular direction, to the extent that heat diffusion coefficients can be up to 10{sup 12} times larger in the parallel direction than in the perpendicular direction. This anisotropy puts stringent requirements on the numerical methods used to approximate the MHD-equations since any misalignment of the grid may cause the perpendicular diffusion to be polluted by the numerical error in approximating the parallel diffusion. Currently the common approach is to apply magnetic field-aligned coordinates, an approach that automatically takes care of the directionality of the diffusive coefficients. This approach runs into problems at x-points and at points where there is magnetic re-connection, since this causes local non-alignment. It is therefore useful to consider numerical schemes that are tolerant to the misalignment of the grid with the magnetic field lines, both to improve existing methods and to help open the possibility of applying regular non-aligned grids. To investigate this, in this paper several discretization schemes are developed and applied to the anisotropic heat diffusion equation on a non-aligned grid.
On Backus average for generally anisotropic layers
Bos, Len; Slawinski, Michael A; Stanoev, Theodore
2016-01-01
In this paper, following the Backus (1962) approach, we examine expressions for elasticity parameters of a homogeneous generally anisotropic medium that is long-wave-equivalent to a stack of thin generally anisotropic layers. These expressions reduce to the results of Backus (1962) for the case of isotropic and transversely isotropic layers. In over half-a-century since the publications of Backus (1962) there have been numerous publications applying and extending that formulation. However, neither George Backus nor the authors of the present paper are aware of further examinations of mathematical underpinnings of the original formulation; hence, this paper. We prove that---within the long-wave approximation---if the thin layers obey stability conditions then so does the equivalent medium. We examine---within the Backus-average context---the approximation of the average of a product as the product of averages, and express it as a proposition in terms of an upper bound. In the presented examination we use the e...
Lysosomal sphingomyelinase is not solicited for apoptosis signaling.
Bezombes, C; Ségui, B; Cuvillier, O; Bruno, A P; Uro-Coste, E; Gouazé, V; Andrieu-Abadie, N; Carpentier, S; Laurent, G; Salvayre, R; Jaffrézou, J P; Levade, T
2001-02-01
Stress-induced activation of an acidic sphingomyelinase leading to generation of ceramide, an important lipid mediator, has been associated with apoptosis; however, the implication of this hydrolase has been questioned. The present study aimed at re-evaluating the role of this lysosomal enzyme in apoptosis initiated by different apoptotic inducers. The sensitivity of a series of acid sphingomyelinase-deficient cell lines derived from Niemann-Pick disease patients to stress-induced apoptosis was investigated. We have now shown that stress stimuli, such as anthracyclines, ionizing radiation, and Fas ligation trigger similar apoptotic hallmarks in normal and acid sphingomyelinase-deficient cell lines. Retrovirus-mediated gene correction of enzyme deficiency in Niemann-Pick cells does not modify response to apoptosis. Ceramide production is comparable in normal and Niemann-Pick cells, and increased activity of neutral sphingomyelinase is observed. Thus, our findings cast serious doubts that lysosomal sphingomyelinase activation is responsible for stress-induced apoptosis of cultured cells. PMID:11156942
Modeling and Measurements of CMUTs with Square Anisotropic Plates
DEFF Research Database (Denmark)
la Cour, Mette Funding; Christiansen, Thomas Lehrmann; Dahl-Petersen, Christian;
2013-01-01
The conventional method of modeling CMUTs use the isotropic plate equation to calculate the deflection, leading to deviations from FEM simulations including anisotropic effects of around 10% in center deflection. In this paper, the deflection is found for square plates using the full anisotropic ...
Long-Range Surface Plasmons on Highly Anisotropic Dielectric Substrates
Gumen, L.; Nagaraj; Neogi, A.; Krokhin, A.
We calculate the propagation length of surface plasmons in metal-dielectric structures with anisotropic substrates. We show that the Joule losses can be minimized by appropriate orientation of the optical axis of a birefringent substrate and that the favorable orientation of the axis depends on ω. A simple Kronig-Penney model for anisotropic plasmonic crystal is also proposed.
Anisotropic conductivity tensor imaging using magnetic induction tomography
International Nuclear Information System (INIS)
Magnetic induction tomography aims to reconstruct the electrical conductivity distribution of the human body using non-contact measurements. The potential of the method has been demonstrated by various simulation studies and a number of phantom experiments. These studies have all relied on models having isotropic distributions of conductivity, although the human body has a highly heterogeneous structure with partially anisotropic properties. Therefore, whether the conventional modeling approaches used so far are appropriate for clinical applications or not is still an open question. To investigate the problem, we performed a simulation study to investigate the feasibility of (1) imaging anisotropic perturbations within an isotropic medium and (2) imaging isotropic perturbations inside a partially anisotropic background. The first is the case for the imaging of anomalies that have anisotropic characteristics and the latter is the case e.g. in lung imaging where an anisotropic skeletal muscle tissue surrounds the lungs and the rib cage. An anisotropic solver based on the singular value decomposition was used to attain conductivity tensor images to be compared with the ones obtained from isotropic solvers. The results indicate the importance of anisotropic modeling in order to obtain satisfactory reconstructions, especially for the imaging of the anisotropic anomalies, and address the resolvability of the conductivity tensor components
Interpolation theory of anisotropic finite elements and applications
Institute of Scientific and Technical Information of China (English)
2008-01-01
Interpolation theory is the foundation of finite element methods.In this paper,after reviewing some existed interpolation theorems of anisotropic finite element methods,we present a new way to analyse the interpolation error of anisotropic elements based on Newton’s formula of polynomial interpolation as well as its applications.
Interpolation theory of anisotropic finite elements and applications
Institute of Scientific and Technical Information of China (English)
CHEN ShaoChun; XIAO LiuChao
2008-01-01
Interpolation theory is the foundation of finite element methods. In this paper, after reviewing some existed interpolation theorems of anisotropic finite element methods, we present a new way to analyse the interpolation error of anisotropic elements based on Newton's formula of polynomial interpolation as well as its applications.
Anisotropic Dark Energy and the Generalized Second Law of Thermodynamics
M. Sharif; Khanum, Farida
2011-01-01
We consider a Bianchi type $I$ model in which anisotropic dark energy is interacting with dark matter and anisotropic radiation. With this scenario, we investigate the validity of the generalized second law of thermodynamics. It is concluded that the validity of this law depends on different parameters like shear, skewness and equation of state.
Anisotropic dark energy and the generalized second law of thermodynamics
International Nuclear Information System (INIS)
We consider a Bianchi type I model in which anisotropic dark energy is interacting with dark matter and anisotropic radiation. With this scenario, we investigate the validity of the generalized second law of thermodynamics. It is concluded that the validity of this law depends on different parameters such as shear, skewness and equation of state.
Zhi Pan; Andrew Avila; Lauren Gollahon
2014-01-01
Previously, we reported that endoplasmic reticulum calcium stores were a direct target for paclitaxel initiation of apoptosis. Furthermore, the actions of paclitaxel attenuated Bcl-2 resistance to apoptosis through endoplasmic reticulum-mediated calcium release. To better understand the calcium-regulated mechanisms of paclitaxel-induced apoptosis in breast cancer cells, we investigated the role of extracellular calcium, specifically; whether influx of extracellular calcium contributed to and...
Orthonormal bases for anisotropic α-modulation spaces
DEFF Research Database (Denmark)
Rasmussen, Kenneth Niemann
2012-01-01
In this article we construct orthonormal bases for bi-variate anisotropic α-modulation spaces. The construction is based on generating a nice anisotropic α-covering and using carefully selected tensor products of univariate brushlet functions with regards to this covering. As an application, we s...... show that n-term nonlinear approximation with the orthonormal bases in certain anisotropic α-modulation spaces can be completely characterized.......In this article we construct orthonormal bases for bi-variate anisotropic α-modulation spaces. The construction is based on generating a nice anisotropic α-covering and using carefully selected tensor products of univariate brushlet functions with regards to this covering. As an application, we...
Orthonormal bases for anisotropic α-modulation spaces
DEFF Research Database (Denmark)
Rasmussen, Kenneth Niemann
In this article we construct orthonormal bases for bi-variate anisotropic α-modulation spaces. The construction is based on generating a nice anisotropic α-covering and using carefully selected tensor products of univariate brushlet functions with regards to this covering. As an application, we s...... show that n-term nonlinear approximation with the orthonormal bases in certain anisotropic α-modulation spaces can be completely characterized.......In this article we construct orthonormal bases for bi-variate anisotropic α-modulation spaces. The construction is based on generating a nice anisotropic α-covering and using carefully selected tensor products of univariate brushlet functions with regards to this covering. As an application, we...
Anisotropic Diffusion in Mesh-Free Numerical Magnetohydrodynamics
Hopkins, Philip F
2016-01-01
We extend recently-developed mesh-free Lagrangian methods for numerical magnetohydrodynamics (MHD) to arbitrary anisotropic diffusion equations, including: passive scalar diffusion, Spitzer-Braginskii conduction and viscosity, cosmic ray diffusion/streaming, anisotropic radiation transport, non-ideal MHD (Ohmic resistivity, ambipolar diffusion, the Hall effect), and turbulent 'eddy diffusion.' We study these as implemented in the code GIZMO for both new meshless finite-volume Godunov schemes (MFM/MFV) as well as smoothed-particle hydrodynamics (SPH). We show the MFM/MFV methods are accurate and stable even with noisy fields and irregular particle arrangements, and recover the correct behavior even in arbitrarily anisotropic cases. They are competitive with state-of-the-art AMR/moving-mesh methods, and can correctly treat anisotropic diffusion-driven instabilities (e.g. the MTI and HBI, Hall MRI). We also develop a new scheme for stabilizing anisotropic tensor-valued fluxes with high-order gradient estimators ...
Anisotropic phenomena in gauge/gravity duality
International Nuclear Information System (INIS)
In this thesis we use gauge/gravity duality to model anisotropic effects realised in nature. Firstly we analyse transport properties in holographic systems with a broken rotational invariance. Secondly we discuss geometries dual to IR fixed points with anisotropic scaling behaviour, which are related to quantum critical points in condensed matter systems. Gauge/gravity duality relates a gravity theory in Anti-de Sitter space to a lower dimensional strongly coupled quantum field theory in Minkowski space. Over the past decade this duality provided many insights into systems at strong coupling, e.g. quark-gluon plasma and condensed matter close to quantum critical points. One very important result computed in this framework is the value of the shear viscosity divided by the entropy density in strongly coupled theories. The quantitative result agrees very well with measurements of the ratio in quark-gluon plasma. However, for isotropic two derivative Einstein gravity it is temperature independent. We show that by breaking the rotational symmetry of a system we obtain a temperature dependent shear viscosity over entropy density. This is important to make contact with real world systems, since substances in nature display such dependence. In addition, we derive various transport properties in strongly coupled anisotropic systems using the gauge/gravity dictionary. The most notable results include an electrical conductivity with Drude behaviour in the low frequency region. This resembles conductors with broken translational invariance. However, we did not implement the breaking explicitly. Furthermore, our analysis shows that this setup models effects, resembling the piezoelectric and exoelectric effects, known from liquid crystals. In a second project we discuss a geometry with non-trivial scaling behaviour in order to model an IR fixed point of condensed matter theories. We construct the UV completion of this geometry and analyse its properties by computing the
Fadeyeva, T A; Volyar, A V
2008-01-01
We consider the propagation of a tilted high order paraxial vortex-beam through a homogeneous anisotropic medium of a uniaxial crystal. We found that the initially circularly polarized beam bearing the l-order optical vortex splits into ordinary and extraordinary beams with a complex vortex structure. After a series of dislocation reactions the vortices gather together at the axis of the partial beam with the initial circular polarization shaping the l-order optical vortex. However, only l-1 vortices gather together on the axis of the partial beam with the orthogonal circular polarization. One optical vortex is shifted along the direction perpendicular to the inclination plane of the beam. Such a vortex displacement induces the transverse shift of the partial beam. In fact, we deal with the beam quadrefringence in a uniaxial, homogeneous anisotropic medium. The first two beams is a result of the splitting of the initial tilted beam into the ordinary and extraordinary once.
Involvement of ASK1 activation in apoptosis induced by NPe6-PDT
Liu, Lei; Zhang, Zhen-zhen; Zhang, Zhigang
2010-02-01
Photodynamic therapy (PDT) employing photosensiter N-aspartyl chlorin e6 (NPe6) can induce lysosome disruption and initiate apoptotic pathway. Apoptosis signal-regulating kinase (ASK1) is an important regulator of apoptosis in response to various stresses, such as reactive oxygen species (ROS), endoplasmic reticulum (ER) stress, lipopolysaccharide (LPS) and calcium influx. In this study, we investigated the molecular mechanisms of apoptosis induced by NPe6-PDT in ASTC-a-1 cells. The results showed that the activities of ASK1 increased in response to NPe6-PDT. Over-expression of wild-type or activated mutant of ASK1 could obviously decrease cell viability and increase cell death; while inhibition of ASK1 significantly decreased cell apoptosis. These results suggested that ASK1 plays an important role in apoptosis induced by NPe6-PDT.
Anisotropic estimates for sub-elliptic operators
Institute of Scientific and Technical Information of China (English)
John; BLAND; Tom; DUCHAMP
2008-01-01
In the 1970’s,Folland and Stein studied a family of subelliptic scalar operators L_λwhich arise naturally in the(?)_b-complex.They introduced weighted Sobolev spaces as the natural spaces for this complex,and then obtained sharp estimates for(?)b in these spaces using integral kernels and approximate inverses.In the 1990’s,Rumin introduced a differential complex for compact contact manifolds,showed that the Folland-Stein operators are central to the analysis for the corresponding Laplace operator,and derived the necessary estimates for the Laplacian from the Folland Stein analysis. In this paper,we give a self-contained derivation of sharp estimates in the anisotropic Folland-Stein spaces for the operators studied by Rumin using integration by parts and a modified approach to bootstrapping.
Surface phonon polaritons on anisotropic piezoelectric superlattices
Chao, Yuanxi; Sheng, Jiteng; Sedlacek, Jonathon A.; Shaffer, James P.
2016-01-01
A theoretical study of surface phonon polaritons (SPhPs) on periodically poled lithium niobate and periodically poled lithium tantalate surfaces is presented. We calculate the dielectric response for six different superlattice orientations and the associated SPhP dispersion relations. Our study of SPhPs accounts for the anisotropic nature of the dielectric response of the semi-infinite piezoelectric superlattices. We find that two different types of SPhPs can be supported. The first type consists of real surface dipole oscillations coupled to photons. The second type consists of virtual surface dipole oscillations driven by the incident photons. The dependence of the SPhPs on temperature and superlattice geometry is addressed. The use of these metamaterial excitations is discussed in the context of hybrid quantum systems.
Anisotropic plasmas from axion and dilaton deformations
Donos, Aristomenis; Sosa-Rodriguez, Omar
2016-01-01
We construct black hole solutions of type IIB supergravity that are holographically dual to anisotropic plasmas arising from deformations of an infinite class of four-dimensional CFTs. The CFTs are dual to $AdS_5\\times X_5$, where $X_5$ is an Einstein manifold, and the deformations involve the type IIB axion and dilaton, with non-trivial periodic dependence on one of the spatial directions of the CFT. At low temperatures the solutions approach smooth domain wall solutions with the same $AdS_5\\times X_5$ solution appearing in the far IR. For sufficiently large deformations an intermediate scaling regime appears which is governed by a Lifshitz-like scaling solution. We calculate the DC thermal conductivity and some components of the shear viscosity tensor.
Anisotropic magnetism in field-structured composites
International Nuclear Information System (INIS)
Magnetic field-structured composites (FSCs) are made by structuring magnetic particle suspensions in uniaxial or biaxial (e.g., rotating) magnetic fields, while polymerizing the suspending resin. A uniaxial field produces chainlike particle structures, and a biaxial field produces sheetlike particle structures. In either case, these anisotropic structures affect the measured magnetic hysteresis loops, with the magnetic remanence and susceptibility increased significantly along the axis of the structuring field, and decreased slightly orthogonal to the structuring field, relative to the unstructured particle composite. The coercivity is essentially unaffected by structuring. We present data for FSCs of magnetically soft particles, and demonstrate that the altered magnetism can be accounted for by considering the large local fields that occur in FSCs. FSCs of magnetically hard particles show unexpectedly large anisotropies in the remanence, and this is due to the local field effects in combination with the large crystalline anisotropy of this material. (c) 2000 The American Physical Society
Anisotropic star on pseudo-spheroidal spacetime
Ratanpal, B. S.; Thomas, V. O.; Pandya, D. M.
2016-02-01
A new class of exact solutions of Einstein's field equations representing anisotropic distribution of matter on pseudo-spheroidal spacetime is obtained. The parameters appearing in the model are restricted through physical requirements of the model. It is found that the models given in the present work is compatible with observational data of a wide variety of compact objects like 4U 1820-30, PSR J1903+327, 4U 1608-52, Vela X-1, PSR J1614-2230, SMC X-4, Cen X-3. A particular model of pulsar PSR J1614-2230 is studied in detail and found that it satisfies all physical requirements needed for physically acceptable model.
Recent developments in anisotropic heterogeneous shell theory
Grigorenko, Alexander Ya; Grigorenko, Yaroslav M; Vlaikov, Georgii G
2016-01-01
This volume focuses on the relevant general theory and presents some first applications, namely those based on classical shell theory. After a brief introduction, during which the history and state-of-the-art are discussed, the first chapter presents the mechanics of anisotropic heterogeneous shells, covering all relevant assumptions and the basic relations of 3D elasticity, classical and refined shell models. The second chapter examines the numerical techniques that are used, namely discrete orthogonalization, spline-collocation and Fourier series, while the third highlights applications based on classical theory, in particular, the stress-strain state of shallow shells, non-circular shells, shells of revolution, and free vibrations of conical shells. The book concludes with a summary and an outlook bridging the gap to the second volume.
Hypergratings: nanophotonics in planar anisotropic metamaterials.
Thongrattanasiri, Sukosin; Podolskiy, Viktor A
2009-04-01
We present a technique capable of producing subwavelength focal spots in planar nonresonant structures not limited to the near-field of the source. The approach combines the diffraction gratings that generate the high-wave-vector-number modes and planar slabs of homogeneous anisotropic metamaterials that propagate these waves and combine them at the subwavelength focal spots. In a sense, the technique combines the benefits of Fresnel lens, near-field zone plates, hyperlens, and superlens and at the same time resolves their fundamental limitations. Several realizations of the proposed technique for visible, near-IR, and mid-IR frequencies are proposed, and their performance is analyzed theoretically and numerically. Generalizations of the developed approach for subdiffractional imaging and on-chip photonics are suggested. PMID:19340161
Penta-quark in Anisotropic Lattice QCD
Ishii, N; Iida, H; Oka, M; Okiharu, F; Suganuma, H
2005-01-01
Penta-quark (5Q) baryons are studied using anisotropic lattice QCD for high-precision measurement of temporal correlators. A non-NK-type interpolating field is employed to study the 5Q states with J^P=1/2^{\\pm} and I=0. In J^P=1/2^+ channel, the lowest-lying state is found at m_{5Q} \\simeq 2.25 GeV, which is too massive to be identified as the Theta^+(1540). In J^P=1/2^- channel, the lowest-lying state is found at m_{5Q} \\simeq 1.75 GeV. To distinguish a compact 5Q resonance state from an NK scattering state, a new method with ``hybrid boundary condition (HBC)'' is proposed. As a result of the HBC analysis, the observed state in the negative-parity channel turns out to be an $NK$ scattering state.
Adiabatic theory for anisotropic cold molecule collisions
International Nuclear Information System (INIS)
We developed an adiabatic theory for cold anisotropic collisions between slow atoms and cold molecules. It enables us to investigate the importance of the couplings between the projection states of the rotational motion of the atom about the molecular axis of the diatom. We tested our theory using the recent results from the Penning ionization reaction experiment 4He(1s2s 3S) + HD(1s2) → 4He(1s2) + HD+(1s) + e− [Lavert-Ofir et al., Nat. Chem. 6, 332 (2014)] and demonstrated that the couplings have strong effect on positions of shape resonances. The theory we derived provides cross sections which are in a very good agreement with the experimental findings
Adiabatic theory for anisotropic cold molecule collisions.
Pawlak, Mariusz; Shagam, Yuval; Narevicius, Edvardas; Moiseyev, Nimrod
2015-08-21
We developed an adiabatic theory for cold anisotropic collisions between slow atoms and cold molecules. It enables us to investigate the importance of the couplings between the projection states of the rotational motion of the atom about the molecular axis of the diatom. We tested our theory using the recent results from the Penning ionization reaction experiment (4)He(1s2s (3)S) + HD(1s(2)) → (4)He(1s(2)) + HD(+)(1s) + e(-) [Lavert-Ofir et al., Nat. Chem. 6, 332 (2014)] and demonstrated that the couplings have strong effect on positions of shape resonances. The theory we derived provides cross sections which are in a very good agreement with the experimental findings. PMID:26298122
Adiabatic theory for anisotropic cold molecule collisions
Energy Technology Data Exchange (ETDEWEB)
Pawlak, Mariusz [Schulich Faculty of Chemistry, Technion–Israel Institute of Technology, Haifa 32000 (Israel); Faculty of Chemistry, Nicolaus Copernicus University in Toruń, Gagarina 7, 87-100 Toruń (Poland); Shagam, Yuval; Narevicius, Edvardas [Department of Chemical Physics, Weizmann Institute of Science, Rehovot 76100 (Israel); Moiseyev, Nimrod [Schulich Faculty of Chemistry, Technion–Israel Institute of Technology, Haifa 32000 (Israel); Faculty of Physics, Technion–Israel Institute of Technology, Haifa 32000 (Israel)
2015-08-21
We developed an adiabatic theory for cold anisotropic collisions between slow atoms and cold molecules. It enables us to investigate the importance of the couplings between the projection states of the rotational motion of the atom about the molecular axis of the diatom. We tested our theory using the recent results from the Penning ionization reaction experiment {sup 4}He(1s2s {sup 3}S) + HD(1s{sup 2}) → {sup 4}He(1s{sup 2}) + HD{sup +}(1s) + e{sup −} [Lavert-Ofir et al., Nat. Chem. 6, 332 (2014)] and demonstrated that the couplings have strong effect on positions of shape resonances. The theory we derived provides cross sections which are in a very good agreement with the experimental findings.
Anisotropic Shock Propagation in Single Crystals
Energy Technology Data Exchange (ETDEWEB)
Eggert, J; Hicks, D; Celliers, P; Bradley, D; Cox, J; Unites, W; Collins, G; McWilliams, R; Jeanloz, R; Bruygoo, S; Loubeyre, P
2005-05-26
Most single-crystal shock experiments have been performed in high-symmetry directions while the nature of shock propagation in low-symmetry directions remains relatively unstudied. It is well known that small-amplitude, linear acoustic waves propagating in low-symmetry directions can focus and/or form caustics (Wolfe, 1995). In this report we provide evidence for similar focusing behavior in nonlinear (shock) waves propagating in single crystals of silicon and diamond. Using intense lasers, we have driven non-planar (divergent geometry) shock waves through single-crystals of silicon or diamond and into an isotropic backing plate. On recovery of the backing plates we observe a depression showing evidence of anisotropic plastic strain with well-defined crystallographic registration. We observe 4-, 2-, and 3-fold symmetric impressions for [100], [110], and [111] oriented crystals respectively.
Long-range interaction of anisotropic systems
Zhang, J. Y.
2015-02-01
The first-order electrostatic interaction energy between two far-apart anisotropic atoms depends not only on the distance between them but also on their relative orientation, according to Rayleigh-Schrödinger perturbation theory. Using the first-order interaction energy and the continuum model, we study the long-range interaction between a pair of parallel pristine graphene sheets at zero temperature. The asymptotic form of the obtained potential density, &epsi:(D) &prop: ?D ?3 ?O(D?4), is consistent with the random phase approximation and Lifshitz theory. Accordingly, neglectance of the anisotropy, especially the nonzero first-order interaction energy, is the reason why the widely used Lennard-Jones potential approach and dispersion corrections in density functional theory give a wrong asymptotic form ε(D) &prop: ?D?4. © EPLA, 2015.
Anisotropic thermal conductivity in sheared polypropylene
Energy Technology Data Exchange (ETDEWEB)
Dai, Shao Cong; Tanner, Roger I. [The University of Sydney, Rheology Research Group, School of Aerospace, Mechanical and Mechatronic Engineering, Sydney, NSW (Australia)
2006-01-01
We discuss the anisotropy of the thermal conductivity tensor in polymer flow in this paper. Isotactic polypropylene (iPP) specimens were deformed by injection moulding at high shear rates and by steady shear at low shear rates, and were then quenched. The thermal conductivities parallel and perpendicular to the shear direction were measured using modulated differential scanning calorimetry (MDSC) in accordance with the ASTM E1952-01. The measured results showed that the thermal conductivity of the sheared polymer was anisotropic with an increase in the shear direction. The thermal conductivity can be regarded as varying either with the strain or the stress, as suggested by Van den Brule (1989). In addition to the Van den Brule mechanism, crystallization during flow also changes the thermal conductivity and this effect may often be dominant. Suggestions for procedures in processing computations, based on both effects, are given. (orig.)
Anisotropic dynamic mass density for fluidsolid composites
Wu, Ying
2012-10-01
By taking the low frequency limit of multiple-scattering theory, we obtain the dynamic effective mass density of fluidsolid composites with a two-dimensional rectangular lattice structure. The anisotropic mass density can be described by an angle-dependent dipole solution, to the leading-order of solid concentration. The angular dependence vanishes for the square lattice, but at high solid concentrations there is a structure-dependent factor that contributes to the leading-order solution. In all cases, Woods formula is found to be accurately valid for the effective bulk modulus, independent of the structures. Numerical evaluations from the solutions are shown to be in excellent agreement with finite-element simulations. © 2012 Elsevier B.V.
Electrodynamic features of anisotropic hard superconductors
Voloshin, I F; Fisher, L M; Aksenov, A V; Yampolskij, V A
2001-01-01
The low-frequency electromagnetic response of the superconducting plates, which are characterized by strong anisotropy of the current-carrying capacity in the sample plane, is experimentally and theoretically studied. The measurements are carried out on the polycrystalline textured plates of the Y-123 system as well as on the monocrystal. It is shown that the form of curves describing the dependence of the q relative losses on the h sub 0 alternate field amplitudes is highly sensitive to the h sub 0 vector orientation in the sample plane. The q(h sub 0) dependence by the h sub 0 orientation along one of the main directions of the current anisotropic critical density symmetry the q(h sub 0) dependence is characterized by the single dimensional maximum. Two dimensional maxima are observed on the q(h sub 0) curve by the h sub 0 significant deviation from the main directions
Anisotropic de Gennes Narrowing in Confined Fluids.
Nygård, Kim; Buitenhuis, Johan; Kagias, Matias; Jefimovs, Konstantins; Zontone, Federico; Chushkin, Yuriy
2016-04-22
The collective diffusion of dense fluids in spatial confinement is studied by combining high-energy (21 keV) x-ray photon correlation spectroscopy and small-angle x-ray scattering from colloid-filled microfluidic channels. We find the structural relaxation in confinement to be slower compared to the bulk. The collective dynamics is wave vector dependent, akin to the de Gennes narrowing typically observed in bulk fluids. However, in stark contrast to the bulk, the structure factor and de Gennes narrowing in confinement are anisotropic. These experimental observations are essential in order to develop a microscopic theoretical description of collective diffusion of dense fluids in confined geometries. PMID:27152823
Current collection in an anisotropic plasma
Li, Wei-Wei
1990-01-01
A general method is given to derive the current-potential relations in anisotropic plasmas. Orbit limit current is assumed. The collector is a conductive sphere or an infinite cylinder. Any distribution which is an arbitrary function of the velocity vector can be considered as a superposition of many mono-energetic beams whose current-potential relations are known. The results for two typical pitch angle distributions are derived and discussed in detail. The general properties of the current potential relations are very similar to that of a Maxwellian plasma except for an effective temperature which varies with the angle between the magnetic field and the charging surface. The conclusions are meaningful to generalized geometries.
Current collection in an anisotropic collisionless plasma
Li, Wei-Wei
1992-01-01
A general method is given to derive the current-potential relations in anisotropic plasmas. Orbit limit current is assumed. The collector is a conductive sphere or an infinite cylinder. Any distribution which is an arbitrary function of the velocity vector can be considered as a superposition of many mono-energetic beams whose current-potential relations are known. The results for two typical pitch angle distributions are derived and discussed in detail. The general properties of the current potential relations are very similar to that of a Maxwellian plasma except for an effective temperature which varies with the angle between the magnetic field and the charging surface. The conclusions are meaningful to generalized geometries.
Anisotropic photon migration in human skeletal muscle
International Nuclear Information System (INIS)
It is demonstrated in the short head of the human biceps brachii of 16 healthy subjects (12 males and 4 females) that near infrared photon migration is anisotropic. The probability for a photon to travel along the direction of the muscle fibres is higher (∼0.4) than that of travelling along a perpendicular axis (∼0.3) while in the adipose tissue the probability is the same (∼0.33) in all directions. Considering that the muscle fibre orientation is different depending on the type of muscle considered, and that inside a given skeletal muscle the orientation may change, the present findings in part might explain the intrasubject variability observed in the physiological parameters measured by near infrared spectroscopy techniques. In other words, the observed regional differences might not only be physiological differences but also optical artefacts. (note)
Translation correlations in anisotropically scattering media
Judkewitz, Benjamin; Horstmeyer, Roarke; Vellekoop, Ivo M.; Papadopoulos, Ioannis N.; Yang, Changhuei
2015-08-01
Controlling light propagation across scattering media by wavefront shaping holds great promise for a wide range of communications and imaging applications. But, finding the right shape for the wavefront is a challenge when the mapping between input and output scattered wavefronts (that is, the transmission matrix) is not known. Correlations in transmission matrices, especially the so-called memory effect, have been exploited to address this limitation. However, the traditional memory effect applies to thin scattering layers at a distance from the target, which precludes its use within thick scattering media, such as fog and biological tissue. Here, we theoretically predict and experimentally verify new transmission matrix correlations within thick anisotropically scattering media, with important implications for biomedical imaging and adaptive optics.
A model for anisotropic strange stars
Deb, Debabrata; Ray, Saibal; Rahaman, Farook; Guha, B K
2016-01-01
We attempt to find a singularity free interior solution for a neutral and static stellar model. We consider that (i) the star is made up of anisotropic fluid and (ii) the MIT bag model can be used. The total system is defined by assuming the density profile given by Mak and Harko \\cite{Mak2002}, which satisfies all the physical conditions of a stellar system and is stable by nature. We find that those stellar systems which obey such a non-linear density function must have maximum anisotropy at the surface. We also perform several tests for physical features of the proposed model and show that these are mostly acceptable within certain range. As a special mention, from our investigation we find that the maximum mass and radius of the quark star are $11.811 km$ and $3.53 {M}_{\\odot}$ respectively.
Anisotropic Absorption of Pure Spin Currents.
Baker, A A; Figueroa, A I; Love, C J; Cavill, S A; Hesjedal, T; van der Laan, G
2016-01-29
Spin transfer in magnetic multilayers offers the possibility of ultrafast, low-power device operation. We report a study of spin pumping in spin valves, demonstrating that a strong anisotropy of spin pumping from the source layer can be induced by an angular dependence of the total Gilbert damping parameter, α, in the spin sink layer. Using lab- and synchrotron-based ferromagnetic resonance, we show that an in-plane variation of damping in a crystalline Co_{50}Fe_{50} layer leads to an anisotropic α in a polycrystalline Ni_{81}Fe_{19} layer. This anisotropy is suppressed above the spin diffusion length in Cr, which is found to be 8 nm, and is independent of static exchange coupling in the spin valve. These results offer a valuable insight into the transmission and absorption of spin currents, and a mechanism by which enhanced spin torques and angular control may be realized for next-generation spintronic devices. PMID:26871353
Effective orthorhombic anisotropic models for wavefield extrapolation
Ibanez-Jacome, W.
2014-07-18
Wavefield extrapolation in orthorhombic anisotropic media incorporates complicated but realistic models to reproduce wave propagation phenomena in the Earth\\'s subsurface. Compared with the representations used for simpler symmetries, such as transversely isotropic or isotropic, orthorhombic models require an extended and more elaborated formulation that also involves more expensive computational processes. The acoustic assumption yields more efficient description of the orthorhombic wave equation that also provides a simplified representation for the orthorhombic dispersion relation. However, such representation is hampered by the sixth-order nature of the acoustic wave equation, as it also encompasses the contribution of shear waves. To reduce the computational cost of wavefield extrapolation in such media, we generate effective isotropic inhomogeneous models that are capable of reproducing the firstarrival kinematic aspects of the orthorhombic wavefield. First, in order to compute traveltimes in vertical orthorhombic media, we develop a stable, efficient and accurate algorithm based on the fast marching method. The derived orthorhombic acoustic dispersion relation, unlike the isotropic or transversely isotropic ones, is represented by a sixth order polynomial equation with the fastest solution corresponding to outgoing P waves in acoustic media. The effective velocity models are then computed by evaluating the traveltime gradients of the orthorhombic traveltime solution, and using them to explicitly evaluate the corresponding inhomogeneous isotropic velocity field. The inverted effective velocity fields are source dependent and produce equivalent first-arrival kinematic descriptions of wave propagation in orthorhombic media. We extrapolate wavefields in these isotropic effective velocity models using the more efficient isotropic operator, and the results compare well, especially kinematically, with those obtained from the more expensive anisotropic extrapolator.
Monitoring apoptosis in real time.
Green, Allan M; Steinmetz, Neil D
2002-01-01
Many therapeutically active anticancer treatments exert their effect by the induction of apoptosis and necrosis. Serial biopsies in breast cancer patients have suggested that response to therapy correlates with early posttreatment increases in tumor apoptotic index. Radiolabeled technetium Tc 99m-recombinant human (rh) annexin V provides a noninvasive technique for imaging treatment-induced cell death. Annexin V is a naturally occurring human protein that binds avidly to membrane-associated phosphatidylserine (PS). PS is normally found only on the inner leaflet of the cell membrane double layer, but it is actively transported to the outer layer as an early event in apoptosis and becomes available for annexin binding. Annexin also gains access to PS as a result of the membrane fragmentation associated with necrosis. In vitro studies of apoptosis using fluorescein annexin have shown good correlation with assessments of apoptosis documented by nuclear DNA degradation and caspase activation. In vivo localization of intravenously administered Tc 99m-annexin V has been demonstrated in numerous preclinical models of apoptosis, including anti-Fas-mediated hepatic apoptosis, rejection of allogeneic heterotopic cardiac allografts, cyclophosphamide treatment of murine lymphoma, cyclophosphamide-induced apoptosis in bone marrow, and leukocyte apoptosis associated with abscess formation. Scintigraphic studies in humans using Tc 99m-rh annexin V have demonstrated the feasibility of imaging cell death in acute myocardial infarction, in tumors with a high apoptotic index, and in response to anti-tumor chemotherapy of non-small cell lung cancer, small-cell lung cancer, breast cancer, lymphoma, and sarcoma. Increased localization of Tc 99m-rh annexin V within 1 to 3 days of chemotherapy has been noted in some, but not all, subjects with these tumors. To date, most subjects showing increased Tc 99m-rh annexin V uptake after the first course of chemotherapy have shown objective
Cardiomyocytic apoptosis and heart failure
Institute of Scientific and Technical Information of China (English)
Quanzhou Feng
2008-01-01
Heart failure is a major disease seriously threatening human health.Once left ventricular dysfunction develops,cardiac function usually deteriorates and progresses to congestive heart failure in several months or years even if no factors which accelerate the deterioration repeatedly exist.Mechanism through which cardiac function continually deteriorates is still unclear.Cardiomyocytic apoptosis can occur in acute stage of ischemic heart diseases and the compensated stage of cardiac dysfunction.In this review,we summarize recent advances in understanding the role of cardiomyocytic apoptosis in heart failure.
Mode-coupling effects in anisotropic flow in heavy-ion collisions
Qian, Jing; Liu, Jia
2016-01-01
Higher-order anisotropic flows in heavy-ion collisions are affected by nonlinear mode coupling effects. It has been suggested that the associated nonlinear hydrodynamic response coefficients probe the transport properties and are largely insensitive to the spectrum of initial density fluctuations of the medium created in these collisions. To test this suggestion, we explore nonlinear mode coupling effects in event-by-event viscous fluid dynamics, using two different models for the fluctuating initial density profiles, and compare the nonlinear coupling coefficients between the initial eccentricity vectors before hydrodynamic expansion and the final flow vectors after the expansion. We find significant sensitivity of the mode coupling coefficients to the initial fluctuation spectrum, strong sensitivity to the specific shear viscosity at freeze-out, but only weak dependence on the shear viscosity during hydrodynamic evolution.
Mode-coupling effects in anisotropic flow in heavy-ion collisions
Qian, Jing; Heinz, Ulrich; Liu, Jia
2016-06-01
Higher-order anisotropic flows in heavy-ion collisions are affected by nonlinear mode coupling effects. It has been suggested that the associated nonlinear hydrodynamic response coefficients probe the transport properties and are largely insensitive to the spectrum of initial density fluctuations of the medium created in these collisions. To test this suggestion, we explore nonlinear mode coupling effects in event-by-event viscous fluid dynamics, using two different models for the fluctuating initial density profiles, and compare the nonlinear coupling coefficients between the initial eccentricity vectors before hydrodynamic expansion and the final flow vectors after the expansion. For several mode coupling coefficients we find significant sensitivity to the initial fluctuation spectrum. They all exhibit strong sensitivity to the specific shear viscosity at freeze-out, but only weak dependence on the shear viscosity during hydrodynamic evolution.
Pietruszka, Mariusz
2011-07-01
This paper presents a generalization of the Lockhart equation for plant cell/organ expansion in the anisotropic case. The intent is to take into account the temporal and spatial variation in the cell wall mechanical properties by considering the wall 'extensibility' (Φ), a time- and space-dependent parameter. A dynamic linear differential equation of a second-order tensor is introduced by describing the anisotropic growth process with some key biochemical aspects included. The distortion and expansion of plant cell walls initiated by expansins, a class of proteins known to enhance cell wall 'extensibility', is also described. In this approach, expansin proteins are treated as active agents participating in isotropic/anisotropic growth. Two-parameter models and an equation for describing α- and β-expansin proteins are proposed by delineating the extension of isolated wall samples, allowing turgor-driven polymer creep, where expansins weaken the non-covalent binding between wall polysaccharides. We observe that the calculated halftime (t(1/2) = εΦ(0) log 2) of stress relaxation due to expansin action can be described in mechanical terms. PMID:21227964
Imaging Anisotropic Nanoplasma Dynamics in Superfluid Helium Droplets
Bacellar, Camila; Chatterley, Adam; Lackner, Florian; Pemmaraju, Sri; Tanyag, Rico; Bernando, Charles; Verma, Deepak; O'Connell, Sean; Osipiv, Timur; Ray, Dipanwita; Ferguson, Kenneth; Gorkhover, Tais; Swiggers, Michele; Bucher, Maximilian; Vilesov, Andrey; Bostedt, Christoph; Gessner, Oliver
2016-05-01
The dynamics of strong-field induced nanoplasmas inside superfluid helium droplets are studied using single-shot, single-particle femtosecond time-resolved X-ray coherent diffractive imaging (CDI) at the Linac Coherent Light Source (LCLS). Intense (~ 1015 W/ cm2, ~ 50 fs) 800 nm laser pulses are employed to initiate nanoplasma formation in sub-micron (200 nm - 600 nm) sized helium droplets. The dynamics of the nanoplasma formation and subsequent droplet evolution are probed by x-rays pulses (~ 100 fs, 600 eV) that are delayed with respect to the near-infrared (NIR) pulses by 10's of femtoseconds to hundreds of picoseconds. Pump-probe time-delay dependent effects in the CDI patterns reveal distinct dynamics evolving on multiple timescales. Very fast (electronic dynamics, while slower (>= 1 ps) dynamics are likely associated with structural changes correlated to nuclear motion including droplet disintegration. In particular, the CDI images exhibit strong indications for anisotropic dynamics governed by the NIR polarization axis, providing previously inaccessible insight into the mechanisms of nanoplasma formation and evolution.
Enhancement of non-resonant dielectric cloaks using anisotropic composites
International Nuclear Information System (INIS)
Cloaking techniques conceal objects by controlling the flow of electromagnetic waves to minimize scattering. Herein, the effectiveness of homogenized anisotropic materials in non-resonant dielectric multilayer cloaking is studied. Because existing multilayer cloaking by isotropic materials can be regarded as homogenous anisotropic cloaking from a macroscopic view, anisotropic materials can be efficiently designed through optimization of their physical properties. Anisotropic properties can be realized in two-phase composites if the physical properties of the material are within appropriate bounds. The optimized anisotropic physical properties are identified by a numerical optimization technique based on a full-wave simulation using the finite element method. The cloaking performance measured by the total scattering width is improved by about 2.8% and 25% in eight- and three-layer cylindrical cloaking materials, respectively, compared with multilayer cloaking by isotropic materials. In all cloaking examples, the optimized microstructures of the two-phase composites are identified as the simple lamination of two materials, which maximizes the anisotropy. The same performance as published for eight-layer cloaking by isotropic materials is achieved by three-layer cloaking using the anisotropic material. Cloaking with an approximately 50% reduction of total scattering width is achieved even in an octagonal object. Since the cloaking effect can be realized using just a few layers of the laminated anisotropic dielectric composite, this may have an advantage in the mass production of cloaking devices
Enhancement of non-resonant dielectric cloaks using anisotropic composites
Energy Technology Data Exchange (ETDEWEB)
Takezawa, Akihiro, E-mail: akihiro@hiroshima-u.ac.jp; Kitamura, Mitsuru [Division of Mechanical Systems and Applied Mechanics, Institute of Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashi-Hiroshima, Hiroshima (Japan)
2014-01-15
Cloaking techniques conceal objects by controlling the flow of electromagnetic waves to minimize scattering. Herein, the effectiveness of homogenized anisotropic materials in non-resonant dielectric multilayer cloaking is studied. Because existing multilayer cloaking by isotropic materials can be regarded as homogenous anisotropic cloaking from a macroscopic view, anisotropic materials can be efficiently designed through optimization of their physical properties. Anisotropic properties can be realized in two-phase composites if the physical properties of the material are within appropriate bounds. The optimized anisotropic physical properties are identified by a numerical optimization technique based on a full-wave simulation using the finite element method. The cloaking performance measured by the total scattering width is improved by about 2.8% and 25% in eight- and three-layer cylindrical cloaking materials, respectively, compared with multilayer cloaking by isotropic materials. In all cloaking examples, the optimized microstructures of the two-phase composites are identified as the simple lamination of two materials, which maximizes the anisotropy. The same performance as published for eight-layer cloaking by isotropic materials is achieved by three-layer cloaking using the anisotropic material. Cloaking with an approximately 50% reduction of total scattering width is achieved even in an octagonal object. Since the cloaking effect can be realized using just a few layers of the laminated anisotropic dielectric composite, this may have an advantage in the mass production of cloaking devices.
Enhancement of non-resonant dielectric cloaks using anisotropic composites
Directory of Open Access Journals (Sweden)
Akihiro Takezawa
2014-01-01
Full Text Available Cloaking techniques conceal objects by controlling the flow of electromagnetic waves to minimize scattering. Herein, the effectiveness of homogenized anisotropic materials in non-resonant dielectric multilayer cloaking is studied. Because existing multilayer cloaking by isotropic materials can be regarded as homogenous anisotropic cloaking from a macroscopic view, anisotropic materials can be efficiently designed through optimization of their physical properties. Anisotropic properties can be realized in two-phase composites if the physical properties of the material are within appropriate bounds. The optimized anisotropic physical properties are identified by a numerical optimization technique based on a full-wave simulation using the finite element method. The cloaking performance measured by the total scattering width is improved by about 2.8% and 25% in eight- and three-layer cylindrical cloaking materials, respectively, compared with multilayer cloaking by isotropic materials. In all cloaking examples, the optimized microstructures of the two-phase composites are identified as the simple lamination of two materials, which maximizes the anisotropy. The same performance as published for eight-layer cloaking by isotropic materials is achieved by three-layer cloaking using the anisotropic material. Cloaking with an approximately 50% reduction of total scattering width is achieved even in an octagonal object. Since the cloaking effect can be realized using just a few layers of the laminated anisotropic dielectric composite, this may have an advantage in the mass production of cloaking devices.
Enhancement of non-resonant dielectric cloaks using anisotropic composites
Takezawa, Akihiro; Kitamura, Mitsuru
2014-01-01
Cloaking techniques conceal objects by controlling the flow of electromagnetic waves to minimize scattering. Herein, the effectiveness of homogenized anisotropic materials in non-resonant dielectric multilayer cloaking is studied. Because existing multilayer cloaking by isotropic materials can be regarded as homogenous anisotropic cloaking from a macroscopic view, anisotropic materials can be efficiently designed through optimization of their physical properties. Anisotropic properties can be realized in two-phase composites if the physical properties of the material are within appropriate bounds. The optimized anisotropic physical properties are identified by a numerical optimization technique based on a full-wave simulation using the finite element method. The cloaking performance measured by the total scattering width is improved by about 2.8% and 25% in eight- and three-layer cylindrical cloaking materials, respectively, compared with multilayer cloaking by isotropic materials. In all cloaking examples, the optimized microstructures of the two-phase composites are identified as the simple lamination of two materials, which maximizes the anisotropy. The same performance as published for eight-layer cloaking by isotropic materials is achieved by three-layer cloaking using the anisotropic material. Cloaking with an approximately 50% reduction of total scattering width is achieved even in an octagonal object. Since the cloaking effect can be realized using just a few layers of the laminated anisotropic dielectric composite, this may have an advantage in the mass production of cloaking devices.
Fabrication of anisotropic microparticles by laser ablation and laser heating
Energy Technology Data Exchange (ETDEWEB)
Fukuda, Kozue; Higuchi, Takeshi; Aita, Tadahiro, E-mail: aita@yz.yamagata-u.ac.jp
2015-02-01
Laser ablation and laser heating were used as micro-cutting and micro-bonding tools for fabrication of anisotropic microparticles. By using the techniques, two kinds of anisotropic microparticles to which a polymer film or magnetic particles was attached on their one hemisphere were fabricated from transparent spherical acrylic polymer particles of about 10 μm. In the fabrication of the anisotropic particles to which a polymer film attached, a mono-particle layer of the acrylic polymer particles formed on water surface was transferred on to a target plate coated with a polymer film and the plate was heated so that the particles strongly adhered to the polymer film. The plate was irradiated by 1064 nm or 532 nm pulse light from a Q-switched YAG laser to cause the ablation of the target. The ablation blew off the polymer film together with the acrylic polymer particles from the target plate, which gave the anisotropic particles. Anisotropic particles to which magnetic particles attached on their one hemisphere were fabricated by laser heating. A magnetic particle layer formed on water surface was transferred onto a quartz plate and then the monoparticle layer of the acrylic polymer particles was transferred onto the magnetic particle layer. The magnetic particles were heated by irradiation of 808 nm light from a CW diode laser, which caused the adhesion of the magnetic particles to the polymer particles. Rotation of the obtained magnetically anisotropic particles under rotating magnetic field was demonstrated. - Highlights: • Laser ablation and laser heating were used for fabrication of anisotropic particles. • Anisotropic microparticles having a polymer film or magnetic particles on their one hemisphere were fabricated. • The magnetically anisotropic microparticles rotated under a rotating magnetic field.
Fabrication of anisotropic microparticles by laser ablation and laser heating
International Nuclear Information System (INIS)
Laser ablation and laser heating were used as micro-cutting and micro-bonding tools for fabrication of anisotropic microparticles. By using the techniques, two kinds of anisotropic microparticles to which a polymer film or magnetic particles was attached on their one hemisphere were fabricated from transparent spherical acrylic polymer particles of about 10 μm. In the fabrication of the anisotropic particles to which a polymer film attached, a mono-particle layer of the acrylic polymer particles formed on water surface was transferred on to a target plate coated with a polymer film and the plate was heated so that the particles strongly adhered to the polymer film. The plate was irradiated by 1064 nm or 532 nm pulse light from a Q-switched YAG laser to cause the ablation of the target. The ablation blew off the polymer film together with the acrylic polymer particles from the target plate, which gave the anisotropic particles. Anisotropic particles to which magnetic particles attached on their one hemisphere were fabricated by laser heating. A magnetic particle layer formed on water surface was transferred onto a quartz plate and then the monoparticle layer of the acrylic polymer particles was transferred onto the magnetic particle layer. The magnetic particles were heated by irradiation of 808 nm light from a CW diode laser, which caused the adhesion of the magnetic particles to the polymer particles. Rotation of the obtained magnetically anisotropic particles under rotating magnetic field was demonstrated. - Highlights: • Laser ablation and laser heating were used for fabrication of anisotropic particles. • Anisotropic microparticles having a polymer film or magnetic particles on their one hemisphere were fabricated. • The magnetically anisotropic microparticles rotated under a rotating magnetic field
Glutathione peroxidase-1 protects from CD95-induced apoptosis.
Gouaze, Valerie; Andrieu-Abadie, Nathalie; Cuvillier, Olivier; Malagarie-Cazenave, Sophie; Frisach, Marie-Francoise; Mirault, Marc-Edouard; Levade, Thierry
2002-11-01
Through the induction of apoptosis, CD95 plays a crucial role in the immune response and the elimination of cancer cells. Ligation of CD95 receptor activates a complex signaling network that appears to implicate the generation of reactive oxygen species (ROS). This study investigated the place of ROS production in CD95-mediated apoptosis and the role of the antioxidant enzyme glutathione peroxidase-1 (GPx1). Anti-CD95 antibodies triggered an early generation of ROS in human breast cancer T47D cells that was blocked by overexpression of GPx1 and inhibition of initiator caspase activation. Enforced expression of GPx1 also resulted in inhibition of CD95-induced effector caspase activation, DNA fragmentation, and apoptotic cell death. Resistance to CD95-mediated apoptosis was not due to an increased expression of anti-apoptotic molecules and could be reversed by glutathione-depleting agents. In addition, whereas the anti-apoptotic protein Bcl-xL prevented CD95-induced apoptosis in MCF-7 cells, it did not inhibit the early ROS production. Moreover, Bcl-xL but not GPx1 overexpression could suppress the staurosporine-induced late generation of ROS and subsequent cell death. Altogether, these findings suggest that GPx1 functions upstream of the mitochondrial events to inhibit the early ROS production and apoptosis induced by CD95 ligation. Finally, transgenic mice overexpressing GPx1 were partially protected from the lethal effect of anti-CD95, underlying the importance of peroxide formation (and GPx1) in CD95-triggered apoptosis. PMID:12221075
Wellbore stability analysis in carbonate reservoir considering anisotropic behaviour
Alves, José; Guevara, Nestor; Coelho, Lucia; Baud, Patrick
2010-05-01
Carbonate reservoirs represent a major part of the world oil and gas reserves. In particular, recent discoveries in the pre-salt offshore Brazil place big challenges to exploration and production under high temperatures and pressures (HTHP). During production, the extraction of hydrocarbons reduces pore pressure and thus causes an increase in the effective stress and mechanical compaction in the reservoir. The compactive deformation and failure may be spatially extensive or localized to the vicinity of the wellbore, but in either case the consequences can be economically severe involving surface subsidence, well failure and various production problems. The analysis of wellbore stability and more generally of deformation and failure in carbonate environments hinges upon a relevant constitutive modeling of carbonate rocks over a wide range of porosities, in particular, observed microstructure of samples suggests anisotropic behaviour. In this study, we performed a wellbore stability analysis for a lateral wellbore junction in three dimensions. The complex geometry for the wellbore junction was modeled with tetrahedral finite elements considering a rate independent elastic-plastic isotropic material that presented linear behavior during elastic strain and associated flow rule. A finite element model simulating drilling and production phases were done for field conditions from a deep water reservoir in Campos basin, offshore Brazil. In this context, several scenarios were studied considering true 3D orientation for both in situ stresses and geometry of the wellbore junction itself. We discussed the impact of constitutive modeling, considering anisotropic ductile damage and pressure sensitiveness on the wellbore stability. Parameter values for the analysis were based based on experimental data on two micritic porous carbonates. Series of conventional triaxial experiments were performed at room temperature in dry and wet conditions on samples of Comiso and Tavel
Prediction of Brittle Failure for TBM Tunnels in Anisotropic Rock: A Case Study from Northern Norway
Dammyr, Øyvind
2016-06-01
Prediction of spalling and rock burst is especially important for hard rock TBM tunneling, because failure can have larger impact than in a drill and blast tunnel and ultimately threaten excavation feasibility. The majority of research on brittle failure has focused on rock types with isotropic behavior. This paper gives a review of existing theory and its application before a 3.5-m-diameter TBM tunnel in foliated granitic gneiss is used as a case to study brittle failure characteristics of anisotropic rock. Important aspects that should be considered in order to predict brittle failure in anisotropic rock are highlighted. Foliation is responsible for considerable strength anisotropy and is believed to influence the preferred side of v-shaped notch development in the investigated tunnel. Prediction methods such as the semi- empirical criterion, the Hoek- Brown brittle parameters, and the non-linear damage initiation and spalling limit method give reliable results; but only as long as the angle between compression axis and foliation in uniaxial compressive tests is relevant, dependent on the relation between tunnel trend/plunge, strike/dip of foliation, and tunnel boundary stresses. It is further demonstrated that local in situ stress variations, for example, due to the presence of discontinuities, can have profound impact on failure predictions. Other carefully documented case studies into the brittle failure nature of rock, in particular anisotropic rock, are encouraged in order to expand the existing and relatively small database. This will be valuable for future TBM planning and construction stages in highly stressed brittle anisotropic rock.
Anisotropic Cosmological Model with Variable G and Lambda
Tripathy, S K; Routray, T R
2015-01-01
Anisotropic Bianchi-III cosmological model is investigated with variable gravitational and cosmological constants in the framework of Einstein's general relativity. The shear scalar is considered to be proportional to the expansion scalar. The dynamics of the anisotropic universe with variable G and Lambda are discussed. Without assuming any specific forms for Lambda and the metric potentials, we have tried to extract the time variation of G and Lambda from the anisotropic model. The extracted G and Lambda are in conformity with the present day observation. Basing upon the observational limits, the behaviour and range of the effective equation of state parameter are discussed.
Renormalized anisotropic exchange for representing heat assisted magnetic recording media
Energy Technology Data Exchange (ETDEWEB)
Jiao, Yipeng; Liu, Zengyuan; Victora, R. H., E-mail: victora@umn.edu [MINT Center, Electrical and Computer Engineering, University of Minnesota, Minneapolis, Minnesota 55455 (United States)
2015-05-07
Anisotropic exchange has been incorporated in a description of magnetic recording media near the Curie temperature, as would be found during heat assisted magnetic recording. The new parameters were found using a cost function that minimized the difference between atomistic properties and those of renormalized spin blocks. Interestingly, the anisotropic exchange description at 1.5 nm discretization yields very similar switching and magnetization behavior to that found at 1.2 nm (and below) discretization for the previous isotropic exchange. This suggests that the increased accuracy of anisotropic exchange may also reduce the computational cost during simulation.
Metastability threshold for anisotropic bootstrap percolation in three dimensions
van Enter, Aernout
2011-01-01
In this paper we analyze several anisotropic bootstrap percolation models in three dimensions. We present the order of magnitude for the metastability threshold for a fairly general class of models. In our proofs we use an adaptation of the technique of dimensional reduction. We find that the order of the metastability threshold is generally determined by the "easiest growth direction" in the model. In contrast to the anisotropic bootstrap percolation in two dimensions, in three dimensions the order of the metatstability threshold for anisotropic bootstrap percolation can be equal to that of isotropic bootstrap percolation.
Thermal conductivity measurement of anisotropic material using photothermal deflection method
International Nuclear Information System (INIS)
A complete theoretical treatment of photothermal deflection spectroscopy has been performed for the measurement of thermal conductivities in an anisotropic medium. An analytical solution of three-dimensional heat conduction was obtained by using 2D Fourier Transforms for an anisotropic material irradiated by a laser beam. Thermal conductivity was determined by using the phase angle of deflection at relative positions between the heating and probe beams. Excellent agreement between theoretical and experimental photothermal deflections was obtained. Also, the thermal conductivity in an arbitrary measurement direction for anisotropic materials (Pyrolytic graphite) was measured
Critical exponents of the anisotropic Bak-Sneppen model
Maslov, Sergei; Rios, Paolo De Los; Marsili, Matteo; Zhang, Yi-Cheng
1998-01-01
We analyze the behavior of spatially anisotropic Bak-Sneppen model. We demonstrate that a nontrivial relation between critical exponents tau and mu=d/D, recently derived for the isotropic Bak-Sneppen model, holds for its anisotropic version as well. For one-dimensional anisotropic Bak-Sneppen model we derive a novel exact equation for the distribution of avalanche spatial sizes, and extract the value gamma=2 for one of the critical exponents of the model. Other critical exponents are then det...
Q-factor and absorption enhancement for plasmonic anisotropic nanoparticles
Liu, Wei; Miroshnichenko, Andrey E
2016-01-01
We investigate the scattering and absorption properties of anisotropic metal-dielectric core-shell nanoparticles. It is revealed that the radially anisotropic dielectric layer can accelerate the evanescent decay of the localized resonant surface modes, leading to Q-factor and absorption rate enhancement. Moreover, the absorption cross section can be maximized to reach the single resonance absorption limit. We further show that such artificial anisotropic cladding materials can be realized by isotropic layered structures, which may inspire many applications based on scattering and absorption of plasmonic nanoparticles.
Development of laser ablation plasma by anisotropic self-radiation
Directory of Open Access Journals (Sweden)
Ohnishi Naofumi
2013-11-01
Full Text Available We have proposed a method for reproducing an accurate solution of low-density ablation plasma by properly treating anisotropic radiation. Monte-Carlo method is employed for estimating Eddington tensor with limited number of photon samples in each fluid time step. Radiation field from ablation plasma is significantly affected by the anisotropic Eddington tensor. Electron temperature around the ablation surface changes with the radiation field and is responsible for the observed emission. An accurate prediction of the light emission from the laser ablation plasma requires a careful estimation of the anisotropic radiation field.
Renormalized anisotropic exchange for representing heat assisted magnetic recording media
International Nuclear Information System (INIS)
Anisotropic exchange has been incorporated in a description of magnetic recording media near the Curie temperature, as would be found during heat assisted magnetic recording. The new parameters were found using a cost function that minimized the difference between atomistic properties and those of renormalized spin blocks. Interestingly, the anisotropic exchange description at 1.5 nm discretization yields very similar switching and magnetization behavior to that found at 1.2 nm (and below) discretization for the previous isotropic exchange. This suggests that the increased accuracy of anisotropic exchange may also reduce the computational cost during simulation
Prediction on instability in planar anisotropic sheet metal forming processes
International Nuclear Information System (INIS)
In this paper instability of planar anisotropic sheet metal during a few forming processes is investigated for the time. For this reason components of the constitutive tangent tensor for planar anisotropic sheets are developed. By using the above tensor location of necking is predicted. Direction of the shear band is also predicted using the acoustic tensor. A finite element program is prepared based on large deformations of planar anisotropic sheet metals. In this program rotations of principal directions of anisotropy are also taken in to account. Results obtained from the presented model are in good agreement with experimental observations
Quantization of the radiation field in an anisotropic dielectric medium
Institute of Scientific and Technical Information of China (English)
Li Wei; Liu Shi-Bing; Yang Wei
2009-01-01
There are both loss and dispersion characteristics for most dielectric media. In quantum theory the loss in medium is generally described by Langevin force in the Langevin noise (LN) scheme by which the quantization of the radiation field in various homogeneous absorbing dielectrics can be successfully actualized. However, it is invalid for the anisotropic dispersion medium. This paper extends the LN theory to an anisotropic dispersion medium and presented the quantization of the radiation field as well as the transformation relation between the homogeneous and anisotropic dispersion media.
Apoptosis detection in histological sections
Czech Academy of Sciences Publication Activity Database
Matalová, Eva; Dubská, Lenka; Míšek, Ivan
2003-01-01
Roč. 72, č. 7 (2003), s. 18-19. ISSN 0001-7213. [Congress of the European Association of Veterinary Anatomists/24./. 21.07.2002-25.07.2002, Brno] R&D Projects: GA ČR GP204/02/P112 Institutional research plan: CEZ:AV0Z5045916 Keywords : apoptosis Subject RIV: FF - HEENT, Dentistry
Institute of Scientific and Technical Information of China (English)
Ding Yi; Chang Cunqing; Xie Lan; Chen Zhimin; Ai Hua
2014-01-01
Background Intense exercise can cause injury and apoptosis,but few studies have reported its effect on the central nervous system (CNS).The initial reason for hippocampus injury is the excitotoxicity of glutamate and calcium overload.Intracellular free Ca2+ ([Ca2+]i) overload may trigger the apoptosis pathway and neuron damage.The aim of this study was to investigate whether intense exercise could cause hippocampus apoptosis and neuron damage and then to determine which pathway was activated by this apoptosis.Methods We used one bout of swimming exhaustion rats as models.Intracellular [Ca2+]i was measured to estimate the calcium overload by Fura-2/AM immediately after exhaustion; glial fibrillary acidic protein (GFAP) and synaptophysin (SYP)immunofluorescence were performed for estimating astrocyte activation and synapse plasticity 24 hours after exhaustion.Apoptosis cells were displayed using dUTP nick end labelling (TUNEL) stain; endoplasmic reticulum (ER) stress-induced apoptosis pathway and mitochondrial apoptosis pathway were synchronously detected by Western blotting.Results An increasing level of intracellular [Ca2+]i (P ＜0.01) was found in the hippocampus immediately after exhaustion.GFAP and SYP immunofluorescence showed that the astrocytes are activated,and the synapse plasticity collapsed significantly 24 hours after exhaustion.TUNEL stain showed that the number of apoptosis cells were notably raised (P ＜0.01); Western blotting of the apoptosis pathway showed increasing levels of caspase-3 cleavage (P ＜0.01),Bax (P ＜0.01),caspase-12 cleavage (P ＜0.01),C/EBP-homologous protein (CHOP) (P ＜0.01),and phospho-Junaminoterminal kinases (p-JNK; P ＜0.01) and decreasing level of Bcl-2 (P ＜0.01).Our results proved that exhaustion can induce hippocampus injury and apoptosis by [Ca2+]i overload,with collapsed synaptic plasticity as the injury pattern and ER stress-induced apoptosis as the activated pathway.Conclusion Intense exercise can cause
Induction of apoptosis in purified animal and plant nuclei by Xenopus egg extracts
Institute of Scientific and Technical Information of China (English)
JIANGZHENGFAN; SHANZHU; 等
1999-01-01
We have developed a cell-free system that can trigger the nuclei purified from mouse liver and suspensioncultured carrot cells to undergo apoptosis as defined by the formation of apoptotic bodies and nucleosomal DNA fragments.The effects of different divalent cations and cycloheximide on DNA cleavage in this system were assessed.The fact that nuclei of plant cells can be induced to undergo apoptosis in a cell-free animal system suggests that animals and plants share a common signal transduction pathway triggering in the initiation stage of apoptosis.
Protocol for Apoptosis Assay by Flow Cytometry Using Annexin V Staining Method
Lakshmanan, Imayavaramban; Batra, Surinder K
2016-01-01
This assay is used to count the number of cells that have undergone apoptosis. Apoptosis will be detected by initially staining the cells with Annexin V and propidium Iodide solution followed by flow cytometry analysis. It is based on the principle that normal cells are hydrophobic in nature as they express phosphatidyl serine in the inner membrane (side facing the cytoplasm) and when the cells undergo apoptosis, the inner membrane flips to become the outer membrane, thus exposing phosphatidyl serine. The exposed phosphatidyl serine is detected by Annexin V, and propidium iodide stains the necrotic cells, which have leaky DNA content that help to differentiate the apoptotic and necrotic cells.
Neem oil limonoids induces p53-independent apoptosis and autophagy
Srivastava, Pragya; Yadav, Neelu; Lella, Ravi; Schneider, Andrea; Jones, Anthony; Marlowe, Timothy; Lovett, Gabrielle; O’Loughlin, Kieran; Minderman, Hans; Gogada, Raghu; Chandra, Dhyan
2012-01-01
Azadirachta indica, commonly known as neem, has a wide range of medicinal properties. Neem extracts and its purified products have been examined for induction of apoptosis in multiple cancer cell types; however, its underlying mechanisms remain undefined. We show that neem oil (i.e., neem), which contains majority of neem limonoids including azadirachtin, induced apoptotic and autophagic cell death. Gene silencing demonstrated that caspase cascade was initiated by the activation of caspase-9,...
Involvement of FAN in TNF-induced apoptosis
Ségui, Bruno; Cuvillier, Olivier; Adam-Klages, Sabine; Garcia, Virginie; Malagarie-Cazenave, Sophie; Lévêque, Sophie; Caspar-Bauguil, Sylvie; Coudert, Jérôme,; Salvayre, Robert; Krönke, Martin; Levade, Thierry
2001-01-01
TNF-α is a pleiotropic cytokine activating several signaling pathways initiated at distinct intracellular domains of the TNF receptors. Although the C-terminal region is believed to be responsible for apoptosis induction, the functions of more membrane-proximal domains, including the domain that couples to neutral sphingomyelinase activation, are not yet fully elucidated. The roles of this region and of the associated adapter protein FAN (factor associated with neutral SMase activation) in th...
HBXIP functions as a cofactor of survivin in apoptosis suppression
Marusawa, Hiroyuki; Matsuzawa, Shu-ichi; Welsh, Kate; Zou, Hua; Armstrong, Robert; Tamm, Ingo; John C. Reed
2003-01-01
Survivin is an anti-apoptotic protein that is overexpressed in most human cancers. We show that survivin forms complexes with a cellular protein, hepatitis B X-interacting protein (HBXIP), which was originally recognized for its association with the X protein of hepatitis B virus (HBX). Survivin–HBXIP complexes, but neither survivin nor HBXIP individually, bind pro-caspase-9, preventing its recruitment to Apaf1, and thereby selectively suppressing apoptosis initiated via the mitochondria/cyto...
Neem oil limonoids induces p53-independent apoptosis and autophagy.
Srivastava, Pragya; Yadav, Neelu; Lella, Ravi; Schneider, Andrea; Jones, Anthony; Marlowe, Timothy; Lovett, Gabrielle; O'Loughlin, Kieran; Minderman, Hans; Gogada, Raghu; Chandra, Dhyan
2012-11-01
Azadirachta indica, commonly known as neem, has a wide range of medicinal properties. Neem extracts and its purified products have been examined for induction of apoptosis in multiple cancer cell types; however, its underlying mechanisms remain undefined. We show that neem oil (i.e., neem), which contains majority of neem limonoids including azadirachtin, induced apoptotic and autophagic cell death. Gene silencing demonstrated that caspase cascade was initiated by the activation of caspase-9, whereas caspase-8 was also activated late during neem-induced apoptosis. Pretreatment of cancer cells with pan caspase inhibitor, z-VAD inhibited activities of both initiator caspases (e.g., caspase-8 and -9) and executioner caspase-3. Neem induced the release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria, suggesting the involvement of both caspase-dependent and AIF-mediated apoptosis. p21 deficiency caused an increase in caspase activities at lower doses of neem, whereas p53 deficiency did not modulate neem-induced caspase activation. Additionally, neem treatment resulted in the accumulation of LC3-II in cancer cells, suggesting the involvement of autophagy in neem-induced cancer cell death. Low doses of autophagy inhibitors (i.e., 3-methyladenine and LY294002) did not prevent accumulation of neem-induced LC3-II in cancer cells. Silencing of ATG5 or Beclin-1 further enhanced neem-induced cell death. Phosphoinositide 3-kinase (PI3K) or autophagy inhibitors increased neem-induced caspase-3 activation and inhibition of caspases enhanced neem-induced autophagy. Together, for the first time, we demonstrate that neem induces caspase-dependent and AIF-mediated apoptosis, and autophagy in cancer cells. PMID:22915764
Anisotropic nature of radially strained metal tubes
Strickland, Julie N.
Metal pipes are sometimes swaged by a metal cone to enlarge them, which increases the strain in the material. The amount of strain is important because it affects the burst and collapse strength. Burst strength is the amount of internal pressure that a pipe can withstand before failure, while collapse strength is the amount of external pressure that a pipe can withstand before failure. If the burst or collapse strengths are exceeded, the pipe may fracture, causing critical failure. Such an event could cost the owners and their customers millions of dollars in clean up, repair, and lost time, in addition to the potential environmental damage. Therefore, a reliable way of estimating the burst and collapse strength of strained pipe is desired and valuable. The sponsor currently rates strained pipes using the properties of raw steel, because those properties are easily measured (for example, yield strength). In the past, the engineers assumed that the metal would be work-hardened when swaged, so that yield strength would increase. However, swaging introduces anisotropic strain, which may decrease the yield strength. This study measured the yield strength of strained material in the transverse and axial direction and compared them to raw material, to determine the amount of anisotropy. This information will be used to more accurately determine burst and collapse ratings for strained pipes. More accurate ratings mean safer products, which will minimize risk for the sponsor's customers. Since the strained metal has a higher yield strength than the raw material, using the raw yield strength to calculate burst and collapse ratings is a conservative method. The metal has even higher yield strength after strain aging, which indicates that the stresses are relieved. Even with the 12% anisotropy in the strained and 9% anisotropy in the strain aged specimens, the raw yield strengths are lower and therefore more conservative. I recommend that the sponsor continue using the raw
Reinterpreting aircraft measurements in anisotropic scaling turbulence
Directory of Open Access Journals (Sweden)
S. J. Hovde
2009-07-01
Full Text Available Due to both systematic and turbulent induced vertical fluctuations, the interpretation of atmospheric aircraft measurements requires a theory of turbulence. Until now virtually all the relevant theories have been isotropic or "quasi isotropic" in the sense that their exponents are the same in all directions. However almost all the available data on the vertical structure shows that it is scaling but with exponents different from the horizontal: the turbulence is scaling but anisotropic. In this paper, we show how such turbulence can lead to spurious breaks in the scaling and to the spurious appearance of the vertical scaling exponent at large horizontal lags.
We demonstrate this using 16 legs of Gulfstream 4 aircraft near the top of the troposphere following isobars each between 500 and 3200 km in length. First we show that over wide ranges of scale, the horizontal spectra of the aircraft altitude are nearly k^{-5/3}. In addition, we show that the altitude and pressure fluctuations along these fractal trajectories have a high degree of coherence with the measured wind (especially with its longitudinal component. There is also a strong phase relation between the altitude, pressure and wind fluctuations; for scales less than ≈40 km (on average the wind fluctuations lead the pressure and altitude, whereas for larger scales, the pressure fluctuations leads the wind. At the same transition scale, there is a break in the wind spectrum which we argue is caused by the aircraft starting to accurately follow isobars at the larger scales. In comparison, the temperature and humidity have low coherencies and phases and there are no apparent scale breaks, reinforcing the hypothesis that it is the aircraft trajectory that is causally linked to the scale breaks in the wind measurements.
Using spectra and structure functions for the wind, we then estimate their exponents (β, H at small (5/3, 1/3 and large scales (2
DNA Damage, Apoptosis and Langerhans cells – Activators of UV-induced Immune Tolerance
Timares, Laura; Katiyar, Santosh; Elmets, Craig A.
2008-01-01
Solar ultraviolet radiation (UVR) is highly mutagenic but is only partially absorbed by the outer stratum corneum of the epidermis. UVR can penetrate into the deeper layers of the epidermis, depending on melanin content, where it induces DNA damage and apoptosis in epidermal cells, including those in the germinative basal layer. The cellular decision to initiate either the cellular repair processes or undergo apoptosis has evolved to balance the acute need to maintain skin barrier function wi...
Reinterpreting aircraft measurements in anisotropic scaling turbulence
Directory of Open Access Journals (Sweden)
S. Lovejoy
2009-02-01
Full Text Available Due to unavoidable vertical fluctuations, the interpretation of atmospheric aircraft measurements requires a theory of turbulence. Until now virtually all the relevant theories have been isotropic. However almost all the available data on the vertical structure shows that it is scaling but with exponents different from the horizontal: the turbulence is anisotropic not isotropic. In this paper, we show how this can lead to spurious breaks in the scaling and to the spurious appearance of the vertical scaling exponent at large horizontal lags.
We demonstrate this using 16 legs of Gulfstream 4 tropospheric data following isobars each between 500 and 3200 km in length. First we show that the horizontal spectra of the aircraft altitude are nearly k^{−5/3} (although smoothed by aircraft intertia at scales <3 km. In addition, we show that the altitude and pressure fluctuations along these fractal trajectories have a high degree of coherence with the measured wind (especially with its longitudinal component. There is also a strong phase relation between the altitude, pressure and wind fluctuations with all of these effects occurring over the entire range of scales so that the trajectories influence the wind measurements over large ranges of scale. In comparison, the temperature and humidity have no apparent scale breaks and the corresponding coherencies and phases are low reinforcing the hypothesis that it is the aircraft trajectory that is causally linked to the scale breaks in the wind measurements.
Using spectra and structure functions we then estimate the small and large scale exponents finding that they are close to the Kolmogorov values (5/3, 1/3 and the vertical values (2.4, 0.73 respectively (for the spectral and real space scaling exponents (β, H the latter are close to those estimated by drop sondes (2.4, 0.75 in the vertical direction. In addition, for each leg we estimate the energy flux, the sphero
Carbonized-leaf Membrane with Anisotropic Surfaces for Sodium-ion Battery.
Li, Hongbian; Shen, Fei; Luo, Wei; Dai, Jiaqi; Han, Xiaogang; Chen, Yanan; Yao, Yonggang; Zhu, Hongli; Fu, Kun; Hitz, Emily; Hu, Liangbing
2016-01-27
A simple one-step thermal pyrolysis route has been developed to prepare carbon membrane from a natural leaf. The carbonized leaf membrane possesses anisotropic surfaces and internal hierarchical porosity, exhibiting a high specific capacity of 360 mAh/g and a high initial Coulombic efficiency of 74.8% as a binder-free, current-collector-free anode for rechargeable sodium ion batteries. Moreover, large-area carbon membranes with low contact resistance are fabricated by simply stacking and carbonizing leaves, a promising strategy toward large-scale sodium-ion battery developments. PMID:26727650
Microstructure evolution of hot-deformed Nd-Fe-B anisotropic magnets
Energy Technology Data Exchange (ETDEWEB)
Liu, J., E-mail: liu.jun@nims.go.jp; Hono, K. [Elements Strategy Initiative Center for Magnetic Materials, National Institute for Materials Science, Tsukuba 305-0047 (Japan); Graduate School of Pure and Applied Sciences, University of Tsukuba, Tsukuba 305-8577 (Japan); Sepehri-Amin, H.; Ohkubo, T. [Elements Strategy Initiative Center for Magnetic Materials, National Institute for Materials Science, Tsukuba 305-0047 (Japan); Hioki, K.; Hattori, A. [Daido Steel Co. Ltd., Nagoya 457-8545 (Japan)
2014-05-07
The microstructural evolution of hot-deformed Nd-Fe-B magnets in each stage of hot-deformation process was studied using transmission electron microscopy and three dimensional atom probe (3DAP). The anisotropic growth of initially isotropic grains in rapidly solidified alloy occurs by annealing without pressing. 3DAP analyses showed a higher concentration of rare-earth elements in the intergranular phase parallel to the flat surface of platelet shaped Nd{sub 2}Fe{sub 14}B grains compared to that in the intergranular phase at the side of platelets.
Thermalization of anisotropic quark–gluon plasma produced by decays of color flux tubes
International Nuclear Information System (INIS)
Kinetic equations are used to study the thermalization of an anisotropic quark–gluon plasma produced by decays of color flux tubes possibly created during the very early stages of relativistic heavy-ion collisions. The decay rates of the initial color tubes are given by the Schwinger formula, while the collision terms are taken in the relaxation time approximation. By connecting the relaxation time with viscosity we analyze production and thermalization processes in the plasma characterized by different values of the ratio of the shear viscosity to entropy density
SH wave scattering problems in unbounded solid containing anisotropic inclusions
International Nuclear Information System (INIS)
A Volume Integral Equation Method (VIEM) is developed for the effective analysis of elastic wave scattering problems in unbounded solids containing general anisotropic inclusions. It should be noted that this newly developed numerical method does not require Green's function for anisotropic inclusions to solve this class of problems since only Green's function for the unbounded isotropic matrix is necessary for the analysis. This new method can also be applied to general two-dimensional elastodynamic and elastostatic problems with arbitrary shapes and number of anisotropic inclusions and voids or cracks. The detailed analysis of SH wave scattering problems are developed for unbounded isotropic matrix containing orthotropic cylindrical inclusions. Through the analysis of plane elastodynamic and elastostatic problems in unbounded isotropic matrix with orthotropic inclusions, it will be established that this new method is very accurate and effective for solving plane elastic problems in unbounded solids containing general anisotropic inclusions and voids or cracks.
Weibel instability driven by spatially anisotropic density structures
Tomita, Sara
2016-01-01
Observations of afterglows of gamma-ray bursts suggest (GRBs) that post-shock magnetic fields are strongly amplified to about 100 times the shock-compressed value. The Weibel instability appears to play an important role in generating of the magnetic field. However, recent simulations of collisionless shocks in homogeneous plasmas show that the magnetic field generated by the Weibel instability rapidly decays. There must be some density fluctuations in interstellar and circumstellar media. The density fluctuations are anisotropically compressed in the downstream region of relativistic shocks. In this paper, we study the Weibel instability in electron--positron plasmas with the spatially anisotropic density distributions by means of two-dimensional particle-in-cell simulations. We find that large magnetic fields are maintained for a longer time by the Weibel instability driven by the spatially anisotropic density structure. Particles anisotropically escape from the high density region, so that the temperature ...
Hyperbolic metamaterial based on anisotropic Mie-type resonance.
Lan, Chuwen; Bi, Ke; Li, Bo; Cui, Xiaohan; Zhou, Ji; Zhao, Qian
2013-12-01
A hyperbolic metamaterial (MM) based on anisotropic Mie-type resonance is theoretically and experimentally demonstrated in microwave range. Based on the shape-dependent Mie-type resonance, metamaterials with indefinite permeability or permittivity parameters are designed by tailoring the isotropic particle into an anisotropic one. The flat lens consisting of anisotropic dielectric resonators has been designed, fabricated and tested. The experimental observation of refocusing and a plane wave with ominidirectional radiation directly verify the predicted properties, which confirm the potential application in negative index material and superlens. This work will also help to develop all-dielectric anisotropic MM devices such as 3D spatial power combination, cloak, and electromagnetic wave converter, etc. PMID:24514510
Anisotropic thermal conduction in galaxy clusters with MHD in Gadget
Arth, Alexander; Beck, Alexander M; Petkova, Margarita; Lesch, Harald
2014-01-01
We present an implementation of thermal conduction including the anisotropic effects of magnetic fields for SPH. The anisotropic thermal conduction is mainly proceeding parallel to magnetic fields and suppressed perpendicular to the fields. We derive the SPH formalism for the anisotropic heat transport and solve the corresponding equation with an implicit conjugate gradient scheme. We discuss several issues of unphysical heat transport in the cases of extreme ansiotropies or unmagnetized regions and present possible numerical workarounds. We implement our algorithm into the GADGET code and study its behaviour in several test cases. In general, we reproduce the analytical solutions of our idealised test problems, and obtain good results in cosmological simulations of galaxy cluster formations. Within galaxy clusters, the anisotropic conduction produces a net heat transport similar to an isotropic Spitzer conduction model with an efficiency of one per cent. In contrast to isotropic conduction our new formalism ...
Heavy Quark Diffusion in Strongly Coupled Anisotropic Plasmas
Giataganas, Dimitrios
2013-01-01
We study the Langevin diffusion of a relativistic heavy quark in anisotropic strongly coupled theories in the local limit. Firstly, we use the axion space-dependent deformed anisotropic N=4 sYM, where the geometry anisotropy is always prolate, while the pressure anisotropy may be prolate or oblate. For motion along the anisotropic direction we find that the effective temperature for the quark can be larger than the heat bath temperature, in contrast to what happens in the isotropic theory. The longitudinal and transverse Langevin diffusion coefficients depend strongly on the anisotropy, the direction of motion and the transverse direction considered. We analyze the anisotropy effects to the coefficients and compare them to each other and to them of the isotropic theory. To examine the dependence of the coefficients on the type of the geometry, we consider another bottom-up anisotropic model. Changing the geometry from prolate to oblate, certain diffusion coefficients interchange their behaviors. In both aniso...
Simple recurrence matrix relations for multilayer anisotropic thin films.
Cojocaru, E
2000-01-01
Generalized Abelès relations for one anisotropic thin film [E. Cojocaru, Appl. Opt. 36, 2825-2829 (1997)] are developed for light propagation from an isotropic medium of incidence (with refractive index n(0)) within a multilayer anisotropic thin film coated onto an anisotropic substrate. An immersion model is used for which it is assumed that each layer is imaginatively embedded between isotropic gaps of zero thickness and refractive index n(0). This model leads to simple expressions for the resultant transmitted and reflected electric field amplitudes at interfaces. They parallel the Abelès recurrence relations for layered isotropic media. These matrix relations include multiple reflections while they deal with total fields. They can be applied directly to complex stacks of isotropic and anisotropic thin films. PMID:18337882
Modelling of anisotropic compact star of emending class one
Bhar, Piyali; Manna, Tuhina
2016-01-01
In the present article, we have constructed static anisotropic compact star models of Einstein field equations for the spherical symmetric metric of embedding class one. By assuming the particular form of metric function $\
Rational points of bounded height on compactifications of anisotropic tori
Batyrev, V V; Batyrev, Victor V; Tschinkel, Yuri
1994-01-01
We investigate the analytic properties of the zeta-function associated with heights on equivariant compactifications of anisotropic tori over number fields. This allows to verify conjectures about the distribution of rational points of bounded height.
Anisotropic plasma with flows in tokamak: Steady state and stability
International Nuclear Information System (INIS)
An adequate description of equilibrium and stability of anisotropic plasma with macroscopic flows in tokamaks is presented. The Chew-Goldberger-Low (CGL) approximation is consistently used to analyze anisotropic plasma dynamics. The admissible structure of a stationary flow is found to be the same as in the ideal magnetohydrodynamics with isotropic pressure (MHD), which means an allowance for the same relabeling symmetry as in ideal MHD systems with toroidally nested magnetic surfaces. A generalization of the Grad-Shafranov equation for the case of anisotropic plasma with flows confined in the axisymmetric magnetic field is derived. A variational principle was obtained, which allows for a stability analysis of anisotropic pressure plasma with flows, and takes into account the conservation laws resulting from the relabeling symmetry. This principle covers the previous stability criteria for static CGL plasma and for ideal MHD flows in isotropic plasma as well. copyright 1996 American Institute of Physics
Conformal Ricci and Matter Collineations for Anisotropic Fluid
Sharif, M
2007-01-01
We study the consequences of timelike and spaccelike conformal Ricci and conformal matter collineations for anisotropic fluid in the context of General Relativity. Necessary and sufficient conditions are derived for a spacetime with anisotropic fluid to admit conformal Ricci and conformal matter collineations parallel to u^a and x^a. These conditions for timelike and spacelike conformal Ricci and conformal matter collineations for anisotropic fluid reduce to the conditions of perfect fluid when the heat flux and the traceless anisotropic stress tensor vanish. Further, for $\\alpha=0$ (the conformal factor), we recover the earlier results of Ricci collineations and matter collineations in each case of timelike and spacelike conformal Ricci collineations and conformal matter collineations for the perfect fluid. Thus our results give the generalization of the results already available in the literature. It is worth noticing that the conditions of conformal matter collineations can be derived from the conditions o...
Numerical study of the thermal degradation of isotropic and anisotropic polymeric materials
Energy Technology Data Exchange (ETDEWEB)
Soler, E. [Departamento de Lenguajes y Ciencias de la Computacion, ETSI Informatica, Universidad de Malaga, 29071 Malaga (Spain); Ramos, J.I. [Room I-320-D, ETS Ingenieros Industriales, Universidad de Malaga, Plaza El Ejido, s/n, 29013 Malaga (Spain)
2005-08-01
The thermal degradation of two-dimensional isotropic, orthotropic and anisotropic polymeric materials is studied numerically by means of a second-order accurate (in both space and time) linearly implicit finite difference formulation which results in linear algebraic equations at each time step. It is shown that, for both isotropic and orthotropic composites, the monomer mass diffusion tensor plays a role in initiating the polymerization kinetics, the formation of a polymerization kernel and the initial front propagation, whereas the later stages of the polymerization are nearly independent of the monomer mass diffusion tensor. In anisotropic polymeric composites, it has been found that the monomer mass diffusion tensor plays a paramount role in determining the initial stages of the polymerization and the subsequent propagation of the polymerization front, the direction and speed of propagation of which are found to be related to the principal directions of both the monomer mass and the heat diffusion tensors. It is also shown that the polymerization time and temperatures depend strongly on the anisotropy of the mass and heat diffusion tensors. (authors)
Degenerate anisotropic elliptic problems and magnetized plasma simulations
Brull, Stéphane; Deluzet, Fabrice
2010-01-01
This paper is devoted to the numerical approximation of a degenerate anisotropic elliptic problem. The numerical method is designed for arbitrary space-dependent anisotropy directions and does not require any specially adapted coordinate system. It is also designed to be equally accurate in the strongly and the mildly anisotropic cases. The method is applied to the Euler-Lorentz system, in the drift-fluid limit. This system provides a model for magnetized plasmas.
Degenerate anisotropic elliptic problems and magnetized plasma simulations
Brull, Stéphane; Degond, Pierre; Deluzet, Fabrice
2010-01-01
International audience This paper is devoted to the numerical approximation of a degen- erate anisotropic elliptic problem. The numerical method is designed for arbitrary space-dependent anisotropy directions and does not re- quire any specially adapted coordinate system. It is also designed to be equally accurate in the strongly and the mildly anisotropic cases. The method is applied to the Euler-Lorentz system, in the drift-fluid limit. This system provides a model for magnetized plasmas.
Spin and Orbital angular momentum propagation in anisotropic media: theory
Picón, Antonio; Benseny, Albert; Mompart, Jordi; Calvo, Gabriel F.
2011-01-01
This paper is devoted to study the propagation of light beams carrying orbital angular momentum in optically anisotropic media. We first review some properties of homogeneous anisotropic media, and describe how the paraxial formalism is modified in order to proceed with a new approach dealing with a general setting of paraxial propagation along uniaxial inhomogeneous media. This approach is suitable for describing the space-variant-optical-axis phase plates.
Anisotropic static solutions in modelling highly compact bodies
Indian Academy of Sciences (India)
M Chaisi; S D Maharaj
2006-03-01
Einstein field equations for static anisotropic spheres are solved and exact interior solutions obtained. This paper extends earlier treatments to include anisotropic models which accommodate a wider variety of physically viable energy densities. Two classes of solutions are possible. The first class contains the limiting case ∝ -2 for the energy density which arises in many astrophysical applications. In the second class the singularity at the centre of the star is not present in the energy density
Spin and orbital angular momentum propagation in anisotropic media: theory
International Nuclear Information System (INIS)
This paper is devoted to a study of the propagation of light beams carrying orbital angular momentum in optically anisotropic media. We first review some properties of homogeneous anisotropic media, and describe how the paraxial formalism is modified in order to proceed with a new approach dealing with the general setting of paraxial propagation along uniaxial inhomogeneous media. This approach is suitable for describing space-variant optical-axis phase plates
Gamma-beam propagation in the anisotropic medium
V.A. Maisheev
1997-01-01
Propagation of gamma-beam in the anisotropic medium is considered. The simpliest example of such a medium of the general type is a combination of the two linearly polarized monochromatic laser waves with different frequencies (dichromatic wave). The optical properties of this combination are described with the use of the permittivity tensor. The refractive indices and polarization characteristics of normal electromagnetic waves propagating in the anisotropic medium are found. The relations, d...
Modeling operations back extrusion billets thick-walled anisotropic
ПЛАТОНОВ В.И.; Яковлев, С. С.
2014-01-01
The mathematical model is an inverse extrusion thick-walled tube blanks of material having anisotropic mechanical properties cylindrical. Relations are given to assess the kinematics of course materials la, stress and strain states, power operation modes reverse extrusion. The results of theoretical investigations of power modes. You are the manifest effects of process parameters on the power mode of operation isothermal reverse extrusion billets of high anisotropic materials in the short-ter...
Thermal fluctuations and critical behavior in a magnetized, anisotropic plasma
Energy Technology Data Exchange (ETDEWEB)
Hazeltine, R. D.; Mahajan, S. M. [Department of Physics, University of Texas at Austin, Austin, Texas 78712 (United States)
2013-12-15
Thermal fluctuations in a magnetized, anisotropic plasma are studied by applying standard methods, based on the Einstein rule, to the known thermodynamic potential of the system. It is found in particular that magnetic fluctuations become critical when the anisotropy p{sub ∥}−p{sub ⊥} changes sign. By examining the critical region, additional insight on the equations of state for near-critical anisotropic plasma is obtained.
Highly-anisotropic elements for acoustic pentamode applications
Christopher N. Layman; Christina J. Naify; Martin, Theodore P.; Calvo, David C.; Orris, Gregory J.
2012-01-01
Pentamode metamaterials are a class of acoustic metafluids that are characterized by a divergence free modified stress tensor. Such materials have an unconventional anisotropic stiffness and isotropic mass density, which allow themselves to mimic other fluid domains. Here we present a pentamode design formed by an oblique honeycomb lattice and producing customizable anisotropic properties. It is shown that anisotropy in the stiffness can exceed three orders of magnitude, and that it can be re...
Anisotropic Metamaterials as sensing devices in acoustics and electromagnetism
Sánchez-Dehesa Moreno-Cid, José; Torrent Martí, Daniel; Carbonell Olivares, Jorge
2012-01-01
We analyze the properties of acoustic and electromagnetic metamaterials with anisotropic constitutive parameters. Particularly, we analyze the so-called Radial Wave Crystals, which are radially periodic structures verifying the Bloch theorem. This type of crystals can be designed and implemented in acoustics as well as in electromagnetism by using anisotropic metamaterials. In acoustics, we have previously predicted that they can be employed as acoustic cavities with huge quality ...
Hybrid anisotropic materials for wind power turbine blades
Golfman, Yosif
2012-01-01
Based on rapid technological developments in wind power, governments and energy corporations are aggressively investing in this natural resource. Illustrating some of the crucial new breakthroughs in structural design and application of wind energy generation machinery, Hybrid Anisotropic Materials for Wind Power Turbine Blades explores new automated, repeatable production techniques that expand the use of robotics and process controls. These practices are intended to ensure cheaper fabrication of less-defective anisotropic material composites used to manufacture power turbine blades. This boo
Electric and magnetic fields from two-dimensional anisotropic bisyncytia.
Sepulveda, N G; Wikswo, J.P.
1987-01-01
Cardiac tissue can be considered macroscopically as a bidomain, anisotropic conductor in which simple depolarization wavefronts produce complex current distributions. Since such distributions may be difficult to measure using electrical techniques, we have developed a mathematical model to determine the feasibility of magnetic localization of these currents. By applying the finite element method to an idealized two-dimensional bisyncytium with anisotropic conductivities, we have calculated th...
Effective Dirac Hamiltonian for anisotropic honeycomb lattices: Optical properties
Oliva-Leyva, M.; Naumis, Gerardo G.
2016-01-01
We derive the low-energy Hamiltonian for a honeycomb lattice with anisotropy in the hopping parameters. Taking the reported Dirac Hamiltonian for the anisotropic honeycomb lattice, we obtain its optical conductivity tensor and its transmittance for normal incidence of linearly polarized light. Also, we characterize its dichroic character due to the anisotropic optical absorption. As an application of our general findings, which reproduce the previous case of uniformly strained graphene, we study the optical properties of graphene under a nonmechanical distortion.
Modelling anisotropic damage and permeability of mortar under dynamic loads
Chen, W.; MAUREL, O.; REESS, T.; MATALLAH, M.; FERRON, A.; C. La Borderie; G. Pijaudier-Cabot
2011-01-01
This paper deals with the development of a model for concrete subjected to dynamic loads. Shock waves are generated by Pulsed Arc Electro-hydraulic Discharges (PAED) in water and applied to mortar samples. A diphasic model (liquid water and vapour) is implemented in order to describe the electrical discharge and the propagation of shock waves in water. An anisotropic damage model is devised, which takes account of the strain rate effect and the crack closure effect. Coupling between anisotrop...
Anisotropic Smoothing Improves DT-MRI-Based Muscle Fiber Tractography
Buck, Amanda K. W.; Ding, Zhaohua; Elder, Christopher P; Towse, Theodore F.; Damon, Bruce M.
2015-01-01
Purpose To assess the effect of anisotropic smoothing on fiber tracking measures, including pennation angle, fiber tract length, and fiber tract number in the medial gastrocnemius (MG) muscle in healthy subjects using diffusion-weighted magnetic resonance imaging (DW-MRI). Materials and Methods 3T DW-MRI data were used for muscle fiber tractography in the MG of healthy subjects. Anisotropic smoothing was applied at three levels (5%, 10%, 15%), and pennation angle, tract length, fiber tract nu...
Aeroelastic modal dynamics of wind turbines including anisotropic effects
Skjoldan, Peter Fisker; Hansen, Morten Hartvig; Rubak, Rune; Thomsen, Kenneth
2011-01-01
Several methods for aeroelastic modal analysis of a rotating wind turbine are developed and used to analyse the modal dynamics of two simplified models and a complex model in isotropic and anisotropic conditions. The Coleman transformation is used to enable extraction of the modal frequencies, damping, and periodic mode shapes of a rotating wind turbine by describing the rotor degrees of freedom in the inertial frame. This approach is valid only for an isotropic system. Anisotropic systems, e...
Light transport and rotational diffusion in optically anisotropic colloidal suspensions
Sandomirski, Kirill
2006-01-01
We have investigated for the first time the influence of magnetic field on rotational diffusion in anisotropic colloidal suspensions by the method of diffusing wave spectroscopy. It has been established that the change of static properties of the sample in magnetic field exceeds the influence of rotational Brawnian motion of colloidal particles.The main dependencies of magnitude and direction of a magnetic field B on anisotropic diffusion of light has been established. It has been shown that...
Holographic study on the jet quenching parameter in anisotropic systems
Wang, Luying
2016-01-01
We first calculate the jet quenching parameter of an anisotropic plasma with a U(1) chemical potential via the AdS/CFT duality. The effects of charge, anisotropy parameter and quark motion direction on the jet quenching parameter are investigated. We then discuss the situation of anisotropic black brane in the IR region. We study both the jet quenching parameters along the longitudinal direction and transverse plane.
Anisotropic universe with magnetized dark energy
Goswami, G. K.; Dewangan, R. N.; Yadav, Anil Kumar
2016-04-01
In the present work we have searched the existence of the late time acceleration of the Universe filled with cosmic fluid and uniform magnetic field as source of matter in anisotropic Heckmann-Schucking space-time. The observed acceleration of universe has been explained by introducing a positive cosmological constant Λ in the Einstein's field equation which is mathematically equivalent to vacuum energy with equation of state (EOS) parameter set equal to -1. The present values of the matter and the dark energy parameters (Ωm)0 & (Ω_{Λ})0 are estimated in view of the latest 287 high red shift (0.3 ≤ z ≤1.4) SN Ia supernova data's of observed apparent magnitude along with their possible error taken from Union 2.1 compilation. It is found that the best fit value for (Ωm)0 & (Ω_{Λ})0 are 0.2820 & 0.7177 respectively which are in good agreement with recent astrophysical observations in the latest surveys like WMAP [2001-2013], Planck [latest 2015] & BOSS. Various physical parameters such as the matter and dark energy densities, the present age of the universe and deceleration parameter have been obtained on the basis of the values of (Ωm)0 & (Ω_{Λ})0. Also we have estimated that the acceleration would have begun in the past at z = 0.71131 ˜6.2334 Gyrs before from present.
Schroedinger covariance states in anisotropic waveguides
International Nuclear Information System (INIS)
In this paper Squeezed and Covariance States based on Schroedinger inequality and their connection with other nonclassical states are considered for particular case of anisotropic waveguide in LiNiO3. Here, the problem of photon creation and generation of squeezed and Schroedinger covariance states in optical waveguides is solved in two steps: 1. Quantization of electromagnetic field is provided in the presence of dielectric waveguide using normal-mode expansion. The photon creation and annihilation operators are introduced, expanding the solution A-vector(r-vector,t) in a series in terms of the Sturm - Liouville mode-functions. 2. In terms of these operators the Hamiltonian of the field in a nonlinear waveguide is derived. For such Hamiltonian we construct the covariance states as stable (with nonzero covariance), which minimize the Schroedinger uncertainty relation. The evolutions of the three second momenta of q-circumflexj and p-circumflexj are calculated. For this Hamiltonian all three momenta are expressed in terms of one real parameters s only. It is found out how covariance, via this parameter s, depends on the waveguide profile n(x,y), on the mode-distributions u-vectorj(x,y), and on the waveguide phase mismatching Δβ. (author). 37 refs
Anisotropic optical trapping of ultracold erbium atoms
Dulieu, Olivier; Lepers, Maxence; Wyart, Jean-Francois
2014-05-01
We calculate the complex dynamic dipole polarizability of ground-state erbium, a rare-earth atom that was recently Bose-condensed. This quantity determines the trapping conditions of cold atoms in an optical trap. The polarizability is calculated with the sum-over-state formula inherent to second-order perturbation theory. The summation is performed on transition energies and transition dipole moments from ground-state erbium, which are computed using the Racah-Slater least-square fitting procedure provided by the Cowan codes. This allows us to predict several yet unobserved energy levels in the range 25000-31000 cm-1 above the ground state. Regarding the trapping potential, we find that ground-state erbium essentially behaves like a spherically-symmetric atom, in spite of its large electronic angular momentum. We find a mostly isotropic van der Waals interaction between two ground-state erbium atoms, with a coefficient C6iso= 1760 a.u.. On the contrary, the photon-scattering rate is strongly anisotropic with respect to the polarization of the trapping light. also at LERMA, UMR8112, Observatoire de Paris-Meudon, Univ. Pierre et Marie Curie, Meudon, France.
Anisotropic Expansion of the Black Hole Universe
Zhang, Tianxi
2009-01-01
Recently, Zhang proposed a new cosmological model called black hole universe. According to this model, the universe originated from a hot star-like black hole with several solar masses, and grew up through a supermassive black hole with billion solar masses to the present state of temperature and density with hundred billion-trillion solar masses due to continuously inhaling matter from its outside. The structure of the entire space is similarly hierarchical or layered and the evolution is iterative. In each of iteration a universe passes through birth, growth, and death. The entire life of a universe roughly divides into three periods with different rates of expansion: slowly growing child universe, fast expanding adult universe, and gradually dying aged universe. When one universe expands to die out, a new universe grows up from its inside. On the AAS 211th meeting, the black hole universe model was shown to be consistent with Mach's principle, observations, and Einstein's general relativity. This new cosmological model can explain the cosmic microwave background radiation, quasars, and element abundances with the well-developed physics. Dark energy is not required for the universe to accelerate. Inflation is not necessary because the black hole universe does not have the horizon problem. In this presentation, the author will explain why the expansion of the universe is anisotropic as shown by the observed anisotropy of the Hubble constant. He will also compare the significant differences between the black hole universe and the big bang cosmology.
Details of tetrahedral anisotropic mesh adaptation
Jensen, Kristian Ejlebjerg; Gorman, Gerard
2016-04-01
We have implemented tetrahedral anisotropic mesh adaptation using the local operations of coarsening, swapping, refinement and smoothing in MATLAB without the use of any for- N loops, i.e. the script is fully vectorised. In the process of doing so, we have made three observations related to details of the implementation: 1. restricting refinement to a single edge split per element not only simplifies the code, it also improves mesh quality, 2. face to edge swapping is unnecessary, and 3. optimising for the Vassilevski functional tends to give a little higher value for the mean condition number functional than optimising for the condition number functional directly. These observations have been made for a uniform and a radial shock metric field, both starting from a structured mesh in a cube. Finally, we compare two coarsening techniques and demonstrate the importance of applying smoothing in the mesh adaptation loop. The results pertain to a unit cube geometry, but we also show the effect of corners and edges by applying the implementation in a spherical geometry.
Dislocation dynamics in an anisotropic stripe pattern.
Kamaga, Carina; Ibrahim, Fatima; Dennin, Michael
2004-06-01
The dynamics of dislocations confined to grain boundaries in a striped system are studied using electroconvection in the nematic liquid crystal N4. In electroconvection, a striped pattern of convection rolls forms for sufficiently high driving voltages. We consider the case of a rapid change in the voltage that takes the system from a uniform state to a state consisting of striped domains with two different wave vectors. The domains are separated by domain walls along one axis and a grain boundary of dislocations in the perpendicular direction. The pattern evolves through dislocation motion parallel to the domain walls. We report on features of the dislocation dynamics. The kinetics of the domain motion is quantified using three measures: dislocation density, average domain wall length, and total domain wall length per area. All three quantities exhibit behavior consistent with power-law evolution in time, with the defect density decaying as t(-1/3), the average domain wall length growing as t(1/3), and the total domain wall length decaying as t(-1/5). The two different exponents are indicative of the anisotropic growth of domains in the system. PMID:15244714
Cartesian anisotropic mesh adaptation for compressible flow
International Nuclear Information System (INIS)
Simulating transient compressible flows involving shock waves presents challenges to the CFD practitioner in terms of the mesh quality required to resolve discontinuities and prevent smearing. This paper discusses a novel two-dimensional Cartesian anisotropic mesh adaptation technique implemented for compressible flow. This technique, developed for laminar flow by Ham, Lien and Strong, is efficient because it refines and coarsens cells using criteria that consider the solution in each of the cardinal directions separately. In this paper the method will be applied to compressible flow. The procedure shows promise in its ability to deliver good quality solutions while achieving computational savings. The convection scheme used is the Advective Upstream Splitting Method (Plus), and the refinement/ coarsening criteria are based on work done by Ham et al. Transient shock wave diffraction over a backward step and shock reflection over a forward step are considered as test cases because they demonstrate that the quality of the solution can be maintained as the mesh is refined and coarsened in time. The data structure is explained in relation to the computational mesh, and the object-oriented design and implementation of the code is presented. Refinement and coarsening algorithms are outlined. Computational savings over uniform and isotropic mesh approaches are shown to be significant. (author)
The role of apoptosis in pulmonary fibrosis
Directory of Open Access Journals (Sweden)
B. D. Uhal
2008-12-01
Full Text Available Apoptosis has been defined as "gene-directed cellular self-destruction" and is an active process that is tightly regulated by a number of gene products, which promote or block cell death. Apoptotic death can be triggered by a wide variety of stimuli and, importantly, not all cells necessarily undergo apoptosis in response to the same stimulus. Abnormal regulation of apoptosis has been implicated in a wide range of diseases and approaches to modifying apoptosis represent important future therapeutic strategies. Idiopathic pulmonary fibrosis (IPF is a progressive and relentless disease involving scarring of the lung, which has been recognised as the most lethal interstitial lung disease. In the lungs of IPF patients, increased epithelial apoptosis, together with decreased apoptosis of myofibroblasts, represents persistent findings (particularly in areas of collagen deposition supporting an interaction between altered apoptosis and the pathogenesis of the disease. Data from human tissues and animal models are refining current knowledge of the processes involved in this pathogenesis. This has challenged the dogma that IPF is purely a disease of unresolved inflammation by emphasising the central roles played by the alveolar epithelial cell and myofibroblasts and, as part of that role, the importance of altered apoptosis. Evidence suggests blockade of epithelial cell apoptosis can prevent subsequent collagen deposition, and induction of myofibroblast apoptosis, at least theoretically, would be expected to resolve ongoing fibrosis. These two concepts raise the prospect of therapeutic intervention aimed at modifying apoptosis and, thus, fibrosis in idiopathic pulmonary fibrosis.
Buoyant Bubbles in Intracluster Gas: Effects of Magnetic Fields and Anisotropic Viscosity
Dong, Ruobing
2009-01-01
Recent observations by Chandra and XMM-Newton indicate there are complex structures at the cores of galaxy clusters, such as cavities and filaments. One plausible model for the formation of such structures is the interaction of radio jets with the intracluster medium (ICM). To investigate this idea, we use three-dimensional magnetohydrodynamic simulations including anisotropic (Braginskii) viscosity to study the effect of magnetic fields on the evolution and morphology of buoyant bubbles in the ICM. We investigate a range of different initial magnetic field geometries and strengths, and study the resulting x-ray surface brightness distribution for comparison to observed clusters. Magnetic tension forces and viscous transport along field lines tend to suppress instabilities parallel, but not perpendicular, to field lines. Thus, the evolution of the bubble depends strongly on the initial field geometry. We find toroidal field loops initially confined to the interior of the bubble are best able reproduce the obs...
Apoptosis in irradiated murine tumors.
Stephens, L C; Ang, K K; Schultheiss, T E; Milas, L; Meyn, R E
1991-09-01
Early radiation responses of transplantable murine ovarian (OCaI) and hepatocellular (HCaI) carcinomas were examined at 6, 24, 48, 96, and 144 h after single photon doses of 25, 35, or 45 Gy. Previous studies using tumor growth delay and tumor radiocurability assays had shown OCaI tumors to be relatively radiosensitive and HCaI tumors to be radioresistant. At 6 h, approximately 20% of nuclei in OCaI tumors showed aberrations characteristic of cell death by apoptosis. This contrasted to an incidence of 3% in HCaI tumors. Mitotic activity was eliminated in OCaI tumors but was only transiently suppressed in HCaI tumors. At 24-96 h, OCaI tumors continued to display apoptosis and progressive necrosis, whereas HCaI tumors responded by exhibiting marked pleomorphism. Factors other than mitotic activity may influence tumor radiosensitivity, and one of these may be susceptibility to induction of apoptosis (programmed cell death), because this was a prominent early radiation response by the radiosensitive OCaI tumors. PMID:1886987
Modeling the anisotropic shock response of single-crystal RDX
Luscher, Darby
Explosives initiate under impacts whose energy, if distributed homogeneously throughout the material, translates to temperature increases that are insufficient to drive the rapid chemistry observed. Heterogeneous thermomechanical interactions at the meso-scale (i.e. between single-crystal and macroscale) leads to the formation of localized hot spots. Direct numerical simulations of mesoscale response can contribute to our understanding of hot spots if they include the relevant deformation mechanisms that are essential to the nonlinear thermomechanical response of explosive molecular crystals. We have developed a single-crystal model for the finite deformation thermomechanical response of cyclotrimethylene trinitramine (RDX). Because of the low symmetry of RDX, a complete description of nonlinear thermoelasticity requires a careful decomposition of free energy into components that represent the pressure-volume-temperature (PVT) response and the coupling between isochoric deformation and both deviatoric and hydrostatic stresses. An equation-of-state (EOS) based on Debye theory that defines the PVT response was constructed using experimental data and density functional theory calculations. This EOS replicates the equilibrium states of phase transformation from alpha to gamma polymorphs observed in static high-pressure experiments. Lattice thermoelastic parameters defining the coupled isochoric free energy were obtained from molecular dynamics calculations and previous experimental data. Anisotropic crystal plasticity is modeled using Orowan's expression relating slip rate to dislocation density and velocity. Details of the theory will be presented followed by discussion of simulations of flyer plate impact experiments, including recent experiments diagnosed with in situ X-ray diffraction at the Advanced Photon Source. Impact conditions explored within the experimental effort have spanned shock pressures ranging from 1-10 GPa for several crystallographic orientations
Breast ultrasound despeckling using anisotropic diffusion guided by texture descriptors.
Gómez Flores, Wilfrido; Pereira, Wagner Coelho de Albuquerque; Infantosi, Antonio Fernando Catelli
2014-11-01
Breast ultrasound (BUS) is considered the most important adjunct method to mammography for diagnosing cancer. However, this image modality suffers from an intrinsic artifact called speckle noise, which degrades spatial and contrast resolution and obscures the screened anatomy. Hence, it is necessary to reduce speckle artifacts before performing image analysis by means of computer-aided diagnosis systems, for example. In addition, the trade-off between smoothing level and preservation of lesion contour details should be addressed by speckle reduction schemes. In this scenario, we propose a BUS despeckling method based on anisotropic diffusion guided by Log-Gabor filters (ADLG). Because we assume that different breast tissues have distinct textures, in our approach we perform a multichannel decomposition of the BUS image using Log-Gabor filters. Next, the conduction coefficient of anisotropic diffusion filtering is computed using texture responses instead of intensity values as stated originally. The proposed algorithm is validated using both synthetic and real breast data sets, with 900 and 50 images, respectively. The performance measures are compared with four existing speckle reduction schemes based on anisotropic diffusion: conventional anisotropic diffusion filtering (CADF), speckle-reducing anisotropic diffusion (SRAD), texture-oriented anisotropic diffusion (TOAD), and interference-based speckle filtering followed by anisotropic diffusion (ISFAD). The validity metrics are the Pratt's figure of merit, for synthetic images, and the mean radial distance (in pixels), for real sonographies. Figure of merit and mean radial distance indices should tend toward '1' and '0', respectively, to indicate adequate edge preservation. The results suggest that ADLG outperforms the four speckle removal filters compared with respect to simulated and real BUS images. For each method--ADLG, CADF, SRAD, TOAD and ISFAD--the figure of merit median values are 0.83, 0.40, 0.39, 0
TAT-apoptin is efficiently delivered and induces apoptosis in cancer cells.
Guelen, Lars; Paterson, Hugh; Gäken, Joop; Meyers, Michelle; Farzaneh, Farzin; Tavassoli, Mahvash
2004-02-01
Apoptin has been described to induce apoptosis in various human cancer cell lines, but not in normal cells, thus making it an interesting candidate for the development of novel therapeutic strategies. Apoptin was generated and cloned into several mammalian expression vectors. Transfection or microinjection of apoptin cDNA resulted in its expression, initially in the cytoplasm with a filamentous pattern. Subsequently, apoptin entered the nucleus and efficiently induced apoptosis in several cancer cell lines. Nuclear localization was shown to be required for induction of apoptosis. Apoptin expression level was found to be an important determinant of the efficiency of induction of apoptosis. Surprisingly, expression of apoptin or GFP-apoptin cDNA induced apoptosis in some normal cells. When fused to the HIV-TAT protein transduction domain and delivered as a protein, TAT-apoptin was transduced efficiently (>90%) into normal and tumour cells. However, TAT-apoptin remained in the cytoplasm and did not kill normal 6689 and 1BR3 fibroblasts. In contrast TAT-apoptin migrated from the cytoplasm to the nucleus of Saos-2 and HSC-3 cancer cells resulting in apoptosis after 24 h. This study shows that apoptin is a powerful apoptosis-inducing protein with a potential for cancer therapy. PMID:14691460
Game and players: mitochondrial apoptosis and the therapeutic potential of ursodeoxycholic acid.
Solá, Susana; Aranha, Márcia M; Steer, Clifford J; Rodrigues, Cecília M P
2007-07-01
Apoptosis represents a universal and exquisitely efficient cellular suicide pathway essential for a variety of normal biological processes ranging from embryonic development to ageing. In fact, tissue homeostasis is dependent on the perfect balance between positive and negative signals that determines the decision between life and death. Therefore, any imbalance can result in a wide range of pathologic disorders associated with unwanted apoptosis or cell growth. During the apoptotic process, the molecular players interact closely with each other in ways relevant to accelerate or interrupt the cellular death process. In addition, two major pathways of apoptosis activation have been recognized as the "intrinsic" mitochondrial pathway and the "extrinsic" death receptor pathway. Although these pathways act independently to initiate apoptosis, a delicate balance and cross-talk between the extrinsic and intrinsic pathways is thought to occur in many cell types. Interestingly, we have shown that ursodeoxycholic acid (UDCA), an endogenous hydrophilic bile acid, is a potent inhibitor of apoptosis by either stabilizing the mitochondrial membrane or modulating the expression of specific upstream targets. Herein, we review the main effectors involved in the death machinery, describe how they interact to regulate apoptosis, and discuss the main pathways that control cell death and survival. Further, we address multiple interesting targets as well as the potential application of UDCA as a therapeutic modality for apoptosis-related disorders. PMID:17489439
Independent regulation of reovirus membrane penetration and apoptosis by the mu1 phi domain.
Directory of Open Access Journals (Sweden)
Pranav Danthi
2008-12-01
Full Text Available Apoptosis plays an important role in the pathogenesis of reovirus encephalitis. Reovirus outer-capsid protein mu1, which functions to penetrate host cell membranes during viral entry, is the primary regulator of apoptosis following reovirus infection. Ectopic expression of full-length and truncated forms of mu1 indicates that the mu1 phi domain is sufficient to elicit a cell death response. To evaluate the contribution of the mu1 phi domain to the induction of apoptosis following reovirus infection, phi mutant viruses were generated by reverse genetics and analyzed for the capacity to penetrate cell membranes and elicit apoptosis. We found that mutations in phi diminish reovirus membrane penetration efficiency by preventing conformational changes that lead to generation of key reovirus entry intermediates. Independent of effects on membrane penetration, amino acid substitutions in phi affect the apoptotic potential of reovirus, suggesting that phi initiates apoptosis subsequent to cytosolic delivery. In comparison to wild-type virus, apoptosis-defective phi mutant viruses display diminished neurovirulence following intracranial inoculation of newborn mice. These results indicate that the phi domain of mu1 plays an important regulatory role in reovirus-induced apoptosis and disease.
International Nuclear Information System (INIS)
Cancer metastasis, the process of cancer cell migration from a primary to distal location, typically leads to a poor patient prognosis. Hematogenous metastasis is initiated by intravasation of circulating tumor cells (CTCs) into the bloodstream, which are then believed to adhere to the luminal surface of the endothelium and extravasate into distal locations. Apoptotic agents such as tumor necrosis factor apoptosis-inducing ligand (TRAIL), whether in soluble ligand form or expressed on the surface of natural killer cells, have shown promise in treating CTCs to reduce the probability of metastasis. The role of hemodynamic shear forces in altering the cancer cell response to apoptotic agents has not been previously investigated. Here, we report that human colon cancer COLO 205 and prostate cancer PC-3 cells exposed to a uniform fluid shear stress in a cone-and-plate viscometer become sensitized to TRAIL-induced apoptosis. Shear-induced sensitization directly correlates with the application of fluid shear stress, and TRAIL-induced apoptosis increases in a fluid shear stress force- and time-dependent manner. In contrast, TRAIL-induced necrosis is not affected by the application fluid shear stress. Interestingly, fluid shear stress does not sensitize cancer cells to apoptosis when treated with doxorubicin, which also induces apoptosis in cancer cells. Caspase inhibition experiments reveal that shear stress-induced sensitization to TRAIL occurs via caspase-dependent apoptosis. These results suggest that physiological fluid shear forces can modulate receptor-mediated apoptosis of cancer cells in the presence of apoptotic agents. (paper)
Pulse mode of laser photodynamic treatment induced cell apoptosis.
Klimenko, Vladimir V; Knyazev, Nickolay A; Moiseenko, Fedor V; Rusanov, Anatoliy A; Bogdanov, Alexey A; Dubina, Michael V
2016-03-01
One of the factors limiting photodynamic therapy (PDT) is hypoxia in tumor cells during photodynamic action. PDT with pulse mode irradiation and appropriate irradiation parameters could be more effective in the singlet oxygen generation and tissue re-oxygenation than continuous wave (CW) mode. We theoretically demonstrate differences between the cumulative singlet oxygen concentration in PDT using pulse mode and CW mode of laser irradiation. In vitro experimental results show that photodynamic treatment with pulse mode irradiation has similar cytotoxicity to CW mode and induces mainly cell apoptosis, whereas CW mode induces necrotic cell death. We assume that the cumulative singlet oxygen concentration and the temporal distribution of singlet oxygen are important in photodynamic cytotoxicity and apoptosis initiation. We expect our research may improve irradiation protocols and photodynamic therapy efficiency. PMID:26790610
Apoptosis commitment - translating survival signals into decisions on mitochondria
Institute of Scientific and Technical Information of China (English)
James A Keeble; Andrew P Gilmore
2007-01-01
Most defective and unwanted cells die by apoptosis, an exquisitely controlled genetic programme tor removing such cells without damaging the surrounding tissue. Once a cell has committed to apoptosis, the process is remarkably efficient, and is completed within a few minutes of initiation. This point of no return for an apoptotic cell is commonly held to be the point at which the outer mitochondrial membrane is permeabilised, a process regulated by the Bcl-2 family of proteins. How these proteins regulate this decision point is central to diseases such as cancer where apoptotic control is lost. In this review, we will discuss apoptotic signalling and how a cell makes the irreversible decision to die. We will focus on one set of survival signals, those derived by cell adhesion to the extracellular matrix (ECM), and use these to highlight the complexities of apoptotic signalling. In particular, we will illustrate how multiple signalling pathways converge to determine critical cell fate decisions.
Molecular signal transduction in vascular cell apoptosis
Institute of Scientific and Technical Information of China (English)
无
2001-01-01
Apoptosis is a form of genetically programmed cell death, which plays a key role in regulation of cellularity in a variety of tissue and cell types including the cardiovascular tissues. Under both physiological and pathophysiological conditions, various biophysiological and biochemical factors, including mechanical forces, reactive oxygen and nitrogen species, cytokines, growth factors, oxidized lipoproteins, etc., may influence apoptosis of vascular cells. The Fas/Fas ligand/caspase death-signaling pathway, Bcl-2 protein family/mitochondria, the tumor suppressive gene p53, and the proto-oncogene c-myc may be activated in atherosclerotic lesions, and mediates vascular apoptosis during the development of atherosclerosis. Abnormal expression and dysfunction of these apoptosis-regulating genes may attenuate or accelerate vascular cell apoptosis and affect the integrity and stability of atherosclerotic plaques. Clarification of the molecular mechanism that regulates apoptosis may help design a new strategy for treatment of atherosclerosis and its major complication, the acute vascular syndromes.
Multiple anisotropic collisions for advection-diffusion Lattice Boltzmann schemes
Ginzburg, Irina
2013-01-01
This paper develops a symmetrized framework for the analysis of the anisotropic advection-diffusion Lattice Boltzmann schemes. Two main approaches build the anisotropic diffusion coefficients either from the anisotropic anti-symmetric collision matrix or from the anisotropic symmetric equilibrium distribution. We combine and extend existing approaches for all commonly used velocity sets, prescribe most general equilibrium and build the diffusion and numerical-diffusion forms, then derive and compare solvability conditions, examine available anisotropy and stable velocity magnitudes in the presence of advection. Besides the deterioration of accuracy, the numerical diffusion dictates the stable velocity range. Three techniques are proposed for its elimination: (i) velocity-dependent relaxation entries; (ii) their combination with the coordinate-link equilibrium correction; and (iii) equilibrium correction for all links. Two first techniques are also available for the minimal (coordinate) velocity sets. Even then, the two-relaxation-times model with the isotropic rates often gains in effective stability and accuracy. The key point is that the symmetric collision mode does not modify the modeled diffusion tensor but it controls the effective accuracy and stability, via eigenvalue combinations of the opposite parity eigenmodes. We propose to reduce the eigenvalue spectrum by properly combining different anisotropic collision elements. The stability role of the symmetric, multiple-relaxation-times component, is further investigated with the exact von Neumann stability analysis developed in diffusion-dominant limit.
Formulation of cross-anisotropic failure criterion for soils
Directory of Open Access Journals (Sweden)
Yi-fei SUN
2013-10-01
Full Text Available Inherently anisotropic soil fabric has a considerable influence on soil strength. To model this kind of inherent anisotropy, a three-dimensional anisotropic failure criterion was proposed, employing a scalar-valued anisotropic variable and a modified general three- dimensional isotropic failure criterion. The scalar-valued anisotropic variable in all sectors of the deviatoric plane was defined by correlating a normalized stress tensor with a normalized fabric tensor. Detailed comparison between the available experimental data and the corresponding model predictions in the deviatoric plane was conducted. The proposed failure criterion was shown to well predict the failure behavior in all sectors, especially in sector II with the Lode angle ranging between 60º and 120º, where the prediction was almost in accordance with test data. However, it was also observed that the proposed criterion overestimated the strength of dense Santa Monica Beach sand in sector III where the intermediate principal stress ratio b varied from approximately 0.2 to 0.8, and slightly underestimated the strength when b was between approximately 0.8 and 1. The difference between the model predictions and experimental data was due to the occurrence of shear bending, which might reduce the measured strength. Therefore, the proposed anisotropic failure criterion has a strong ability to characterize the failure behavior of various soils and potentially allows a better description of the influence of the loading direction with respect to the soil fabric.
Flux penetration into flat rectangular superconductors with anisotropic critical current
International Nuclear Information System (INIS)
Superconductors with anisotropic critical-current density jc exhibit characteristic anisotropic flux-density patterns during penetration of magnetic flux. We investigate this anisotropic flux penetration in detail by observations using the magneto-optical Faraday effect and by first-principles calculations which describe the superconductor as a nonlinear anisotropic conductor. Our samples are thin plates of DyBa2Cu3O7-δ into which anisotropic pinning is introduced by oblique irradiation with 340-MeV Xe ions creating linear defects. Excellent agreement between experiment and theory is obtained. In particular, we find that in rectangular plates with jc anisotropy equal to the side ratio, the intrinsic and shape anisotropies may compensate such that the flux pattern looks like that in an isotropic square stretched to the rectangular shape. This means the current streamlines are concentric rectangles which shrink to a point rather than to a line, and the discontinuity lines where the current bends sharply, coincide with the diagonals of the rectangle rather than forming the usual double-Y structure. copyright 1997 The American Physical Society
Marshall P. Thomas; Xing Liu; Jennifer Whangbo; Geoffrey McCrossan; Keri B. Sanborn; Emre Basar; Michael Walch; Judy Lieberman
2015-01-01
Apoptosis is a tightly coordinated cell death program that damages mitochondria, DNA, proteins, and membrane lipids. Little is known about the fate of RNA as cells die. Here, we show that mRNAs, but not noncoding RNAs, are rapidly and globally degraded during apoptosis. mRNA decay is triggered early in apoptosis, preceding membrane lipid scrambling, genomic DNA fragmentation, and apoptotic changes to translation initiation factors. mRNA decay depends on mitochondrial outer membrane permeabili...
Deretic, V; Bewley, M. A.; Marriott, H. M.; Tulone, C.; Francis, S E; Mitchell, T J; Read, R. C.; Chain, B.; Kroemer, G; Whyte, M.K.B.; Dockrell, D. H.
2011-01-01
Author Summary Tissue macrophages frequently undergo a program of cell death, termed apoptosis, following sustained ingestion and killing of bacteria. In macrophages, induction of apoptosis enhances bacterial killing when macrophages' initial killing capacity is exhausted. We have investigated the mechanism of apoptosis in macrophages exposed to pneumococci, the commonest cause of bacterial pneumonia. We show that the cell structure containing ingested bacteria, the phagolysosome, becomes per...
Bhattacharya, Poulomi; Madden, Jill A.; Sen, Nivedita; Hoyer, Patricia B.; Keating, Aileen F.
2012-01-01
4-vinylcyclohexene diepoxide (VCD) destroys ovarian primordial and small primary follicles via apoptosis. In mice, VCD exposure induces ovarian mRNA expression of glutathione S-transferase (GST) family members, including isoform mu (Gstm). Extra-ovarian GSTM negatively regulates pro-apoptotic apoptosis signal-related kinase 1 (ASK1) through protein complex formation, which dissociates during stress, thereby initiating ASK1-induced apoptosis. The present study investigated the ovarian response...
DNA degradation and Apoptosis : DNA degradation
Torriglia, Alicia; Padron, Laura
2005-01-01
Apoptosis, is a form of programmed cell death essential for the development and maintenance of multicellular organisms. DNA degradation is one of the hallmarks of apoptosis. The central component of the apoptotic machinery is a proteolytic system involving caspases and non-caspases proteases. CAD, a caspase-activated DNase, is the endonuclease responsible for DNA degradation during caspase-dependent apoptosis. The relationship between non-caspase proteases and endonucleases is less clear and ...
Apoptosis in normal oral tissues and odontogenesis
Ruchita Bali; Akhilesh Chandra; Renuka Verma
2013-01-01
Programmed cell death or apoptosis is considered a vital component of various processes including normal cell turnover, proper development and functioning of the immune system, hormone-dependent atrophy, embryonic development, and chemical-induced cell death. Inappropriate apoptosis (either too little or too much) is a factor in many human conditions including neurodegenerative diseases, ischemic damage, autoimmune disorders, and many types of cancers. The process of apoptosis is generally ch...
Apoptosis: A Review of Programmed Cell Death
Elmore, Susan
2007-01-01
The process of programmed cell death, or apoptosis, is generally characterized by distinct morphological characteristics and energy-dependent biochemical mechanisms. Apoptosis is considered a vital component of various processes including normal cell turnover, proper development and functioning of the immune system, hormone-dependent atrophy, embryonic development and chemical-induced cell death. Inappropriate apoptosis (either too little or too much) is a factor in many human conditions incl...
DEFF Research Database (Denmark)
Torp, Kristian
2009-01-01
increased. In the initial study presented here, the time it takes to pass an intersection is studied in details. Two major signal-controlled four-way intersections in the center of the city Aalborg are studied in details to estimate the congestion levels in these intersections, based on the time it takes to...
Apoptosis in cancer: from pathogenesis to treatment
Directory of Open Access Journals (Sweden)
Wong Rebecca SY
2011-09-01
Full Text Available Abstract Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions. It is also one of the most studied topics among cell biologists. An understanding of the underlying mechanism of apoptosis is important as it plays a pivotal role in the pathogenesis of many diseases. In some, the problem is due to too much apoptosis, such as in the case of degenerative diseases while in others, too little apoptosis is the culprit. Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die. The mechanism of apoptosis is complex and involves many pathways. Defects can occur at any point along these pathways, leading to malignant transformation of the affected cells, tumour metastasis and resistance to anticancer drugs. Despite being the cause of problem, apoptosis plays an important role in the treatment of cancer as it is a popular target of many treatment strategies. The abundance of literature suggests that targeting apoptosis in cancer is feasible. However, many troubling questions arise with the use of new drugs or treatment strategies that are designed to enhance apoptosis and critical tests must be passed before they can be used safely in human subjects.
The cellular decision between apoptosis and autophagy
Directory of Open Access Journals (Sweden)
Yong-Jun Fan
2013-03-01
Full Text Available Apoptosis and autophagy are important molecular processes that maintain organismal and cellular homeostasis, respectively. While apoptosis fulfills its role through dismantling damaged or unwanted cells, autophagy maintains cellular homeostasis through recycling selective intracellular organelles and molecules. Yet in some conditions, autophagy can lead to cell death. Apoptosis and autophagy can be stimulated by the same stresses. Emerging evidence indicates an interplay between the core proteins in both pathways, which underlies the molecular mechanism of the crosstalk between apoptosis and autophagy. This review summarizes recent literature on molecules that regulate both the apoptotic and autophagic processes.
Anisotropic quantum cosmological models a discrepancy between many-worlds and dBB interpretations
Alvarenga, F G; Fabris, J C; Gonçalves, S V B
2002-01-01
In the isotropic quantum cosmological perfect fluid model, the initial singularity can be avoided, while the classical behaviour is recovered asymptotically. We verify if initial anisotropies can also be suppressed in a quantum version of a classical anisotropic model where gravity is coupled to a perfect fluid. Employing a Bianchi I cosmological model, we obtain a "Schr\\"odinger-like" equation where the matter variables play de role of time. This equation has a hyperbolic signature. It can be explicitly solved and a wave packet is constructed. The expectation value of the scale factor, evaluated in the spirit of the many-worlds interpretation, reveals an isotropic Universe. On the other hand, the bohmian trajectories indicate the existence of anisotropies. This is an example where the Bohm-de Broglie and the many-worlds interpretations are not equivalent. It is argued that this inequivalence is due to the hyperbolic structure of the "Schr\\"odinger-like" equation.
Nonequilibrium current-carrying steady states in the anisotropic X Y spin chain
Lancaster, Jarrett L.
2016-05-01
Out-of-equilibrium behavior is explored in the one-dimensional anisotropic X Y model. Initially preparing the system in the isotropic X X model with a linearly varying magnetic field to create a domain-wall magnetization profile, dynamics is generated by rapidly changing the exchange interaction anisotropy and external magnetic field. Relaxation to a nonequilibrium steady state is studied analytically at the critical transverse Ising point, where correlation functions may be computed in closed form. For arbitrary values of anisotropy and external field, an effective generalized Gibbs' ensemble is shown to accurately describe observables in the long-time limit. Additionally, we find spatial oscillations in the exponentially decaying, transverse spin-spin correlation functions with wavelength set by the magnetization jump across the initial domain wall. This wavelength depends only weakly on anisotropy and magnetic field in contrast to the current, which is highly dependent on these parameters.
Wojtuszkiewicz, Anna; Schuurhuis, Gerrit J; Kessler, Floortje L; Piersma, Sander R; Knol, Jaco C; Pham, Thang V; Jansen, Gerrit; Musters, René J P; van Meerloo, Johan; Assaraf, Yehuda G; Kaspers, Gertjan J L; Zweegman, Sonja; Cloos, Jacqueline; Jimenez, Connie R
2016-04-01
Expression of apoptosis-regulating proteins (B-cell CLL/lymphoma 2 - BCL-2, Myeloid Cell Leukemia 1 - MCL-1, BCL-2 like 1 - BCL-X and BCL-2-associated X protein - BAX) in acute myeloid leukemia (AML) blasts at diagnosis is associated with disease-free survival. We previously found that the initially high apoptosis-resistance of AML cells decreased after therapy, while regaining high levels at relapse. Herein, we further explored this aspect of dynamic apoptosis regulation in AML. First, we showed that the intraindividualex vivoapoptosis-related profiles of normal lymphocytes and AML blasts within the bone marrow of AML patients were highly correlated. The expression values of apoptosis-regulating proteins were far beyond healthy control lymphocytes, which implicates the influence of microenvironmental factors. Second, we demonstrated that apoptosis-resistant primary AML blasts, as opposed to apoptosis-sensitive cells, were able to up-regulate BCL-2 expression in sensitive AML blasts in contact cultures (p= 0.0067 andp= 1.0, respectively). Using secretome proteomics, we identified novel proteins possibly engaged in apoptosis regulation. Intriguingly, this analysis revealed that major functional protein clusters engaged in global gene regulation, including mRNA splicing, protein translation, and chromatin remodeling, were more abundant (p= 4.01E-06) in secretomes of apoptosis-resistant AML. These findings were confirmed by subsequent extracellular vesicle proteomics. Finally, confocal-microscopy-based colocalization studies show that splicing factors-containing vesicles secreted by high AAI cells are taken up by low AAI cells. The current results constitute the first comprehensive analysis of proteins released by apoptosis-resistant and sensitive primary AML cells. Together, the data point to vesicle-mediated release of global gene regulatory protein clusters as a plausible novel mechanism of induction of apoptosis resistance. Deciphering the modes of communication
Selenium, apoptosis, and colorectal adenomas.
Connelly-Frost, Alexandra; Poole, Charles; Satia, Jessie A.; Kupper, Lawrence L.; Millikan, Robert C.; Sandler, Robert S.
2006-01-01
Dietary modulation of carcinogenesis-related pathwaysDietary item or component studied:seleniumPathways studied:apoptosisStudy type (in vitro, animals, humans): humansStudy design (if human):cross-sectional studyStudy size (if human):803 participantsTissue/biological material/sample size: serum, 2 colon biopsiesMode of exposure (if in vivo) (acute, chronic, root of exposure):dietary & lifestyle questionnairesImpact on pathway (including dose-response):for 50-120 μgr/l selenium Pe~0.5-0.3For ...
The Shear Viscosity in an Anisotropic Unitary Fermi Gas
Samanta, Rickmoy; Trivedi, Sandip P
2016-01-01
We consider a system consisting of a strongly interacting, ultracold unitary Fermi gas under harmonic confinement. Our analysis suggests the possibility of experimentally studying, in this system, an anisotropic shear viscosity tensor driven by the anisotropy in the trapping potential. In particular, we suggest that this experimental setup could mimic some features of anisotropic geometries that have recently been studied for strongly coupled field theories which have a gravitational dual. Results using the AdS/CFT correspondence in these theories show that in systems with a background linear potential, certain viscosity components can be made much smaller than the entropy density, parametrically violating the KSS bound. This intuition, along with results from a Boltzmann analysis that we perform, suggests that a violation of the KSS bound can perhaps occur in the unitary Fermi gas system when it is subjected to a suitable anisotropic trapping potential. We give a concrete proposal for an experimental setup w...
Computer simulations of the anisotropic Josephson junction arrays
International Nuclear Information System (INIS)
Using complementary methods, we numerically investigate the anisotropic Josephson junction arrays (AJJAs). For various anisotropic strengths (λ), the Monte Carlo simulation gives a precise measurement of specific heat, magnetization, and magnetic susceptibility; while the resistively shunted-junction dynamical simulation produces the current-voltage characteristics. The critical temperatures obtained from the two approaches are well consistent with each other. We find that, except for the anisotropic limit (λ=0), the quasi-long-range order is always established at a finite temperature. Further, the algebraically decaying spin-spin correlations in the low-temperature region are analyzed in detail. Finally, the full phase diagram of the AJJAs, which sheds some lights to the crossover of the XY model from one dimension to two, is constructed. These predictions are to be confronted with future experiments.
Computer simulations of the anisotropic Josephson junction arrays
Energy Technology Data Exchange (ETDEWEB)
Lv Jianping, E-mail: phys.lv@gmail.com [Department of Physics, China University of Mining and Technology, Xuzhou 221116 (China); Zhu Shujing [Department of Physics, Zhejiang University, Hangzhou 310027 (China)
2012-12-15
Using complementary methods, we numerically investigate the anisotropic Josephson junction arrays (AJJAs). For various anisotropic strengths ({lambda}), the Monte Carlo simulation gives a precise measurement of specific heat, magnetization, and magnetic susceptibility; while the resistively shunted-junction dynamical simulation produces the current-voltage characteristics. The critical temperatures obtained from the two approaches are well consistent with each other. We find that, except for the anisotropic limit ({lambda}=0), the quasi-long-range order is always established at a finite temperature. Further, the algebraically decaying spin-spin correlations in the low-temperature region are analyzed in detail. Finally, the full phase diagram of the AJJAs, which sheds some lights to the crossover of the XY model from one dimension to two, is constructed. These predictions are to be confronted with future experiments.
Effects of nonuniform acceptance in anisotropic flow measurements
International Nuclear Information System (INIS)
The applicability of anisotropic flow measurement techniques and their extension for detectors with nonuniform azimuthal acceptance are discussed. Considering anisotropic flow measurements with two and three (mixed harmonic) azimuthal correlations we introduce a set of observables based on the x and y components of the event flow vector. These observables provide independent measures of anisotropic flow and can be used to test the self-consistency of the analysis. Based on these observables we propose a technique that explicitly takes into account the effects of nonuniform detector acceptance. Within this approach the acceptance corrections, as well as parameters that define the method applicability, can be determined directly from experimental data. For practical purposes a brief summary of the method is provided at the end
3-D waveform tomography sensitivity kernels for anisotropic media
Djebbi, R.
2014-01-01
The complications in anisotropic multi-parameter inversion lie in the trade-off between the different anisotropy parameters. We compute the tomographic waveform sensitivity kernels for a VTI acoustic medium perturbation as a tool to investigate this ambiguity between the different parameters. We use dynamic ray tracing to efficiently handle the expensive computational cost for 3-D anisotropic models. Ray tracing provides also the ray direction information necessary for conditioning the sensitivity kernels to handle anisotropy. The NMO velocity and η parameter kernels showed a maximum sensitivity for diving waves which results in a relevant choice of those parameters in wave equation tomography. The δ parameter kernel showed zero sensitivity; therefore it can serve as a secondary parameter to fit the amplitude in the acoustic anisotropic inversion. Considering the limited penetration depth of diving waves, migration velocity analysis based kernels are introduced to fix the depth ambiguity with reflections and compute sensitivity maps in the deeper parts of the model.
Anisotropic models are unitary: A rejuvenation of standard quantum cosmology
Pal, Sridip
2016-01-01
The present work proves that the folk-lore of the pathology of non-conservation of probability in quantum anisotropic models is wrong. It is shown in full generality that all operator ordering can lead to a Hamiltonian with a self-adjoint extension as long as it is constructed to be a symmetric operator, thereby making the problem of non-unitarity in context of anisotropic homogeneous model a ghost. Moreover, it is indicated that the self-adjoint extension is not unique and this non-uniqueness is suspected not to be a feature of Anisotropic model only, in the sense that there exists operator orderings such that Hamiltonian for an isotropic homogeneous cosmological model does not have unique self-adjoint extension, albeit for isotropic model, there is a special unique extension associated with quadratic form of Hamiltonian i.e {\\it Friedrichs extension}. Details of calculations are carried out for a Bianchi III model.
Adaptive anisotropic meshing for steady convection-dominated problems
Energy Technology Data Exchange (ETDEWEB)
Nguyen, Hoa [Tulane University; Gunzburger, Max [Florida State University; Ju, Lili [University of South Carolina; Burkardt, John [Florida State University
2009-01-01
Obtaining accurate solutions for convection–diffusion equations is challenging due to the presence of layers when convection dominates the diffusion. To solve this problem, we design an adaptive meshing algorithm which optimizes the alignment of anisotropic meshes with the numerical solution. Three main ingredients are used. First, the streamline upwind Petrov–Galerkin method is used to produce a stabilized solution. Second, an adapted metric tensor is computed from the approximate solution. Third, optimized anisotropic meshes are generated from the computed metric tensor by an anisotropic centroidal Voronoi tessellation algorithm. Our algorithm is tested on a variety of two-dimensional examples and the results shows that the algorithm is robust in detecting layers and efficient in avoiding non-physical oscillations in the numerical approximation.
Critical exponents of the anisotropic Bak-Sneppen model
Energy Technology Data Exchange (ETDEWEB)
Maslov, S. [Department of Physics, Brookhaven National Laboratory, Upton, New York 11973 (United States); De Los Rios, P.; Marsili, M.; Zhang, Y. [Institut de Physique Theorique, Universite de Fribourg Perolles, Fribourg CH-1700 (Switzerland); Marsili, M. [International School for Advanced Studies (SISSA) and INFM Unit, Trieste I-34014 (Italy)
1998-12-01
We analyze the behavior of the spatially anisotropic Bak-Sneppen model. We demonstrate that a nontrivial relation between critical exponents {tau} and {mu}=d/D, recently derived for the isotropic Bak-Sneppen model, holds for its anisotropic version as well. For the one-dimensional anisotropic Bak-Sneppen model, we derive an exact equation for the distribution of avalanche spatial sizes, and extract the value {gamma}=2 for one of the critical exponents of the model. Other critical exponents are then determined from previously known exponent relations. Our results are in excellent agreement with Monte Carlo simulations of the model as well as with direct numerical integration of the new equation. {copyright} {ital 1998} {ital The American Physical Society}
Innovative anisotropic phantoms for calibration of diffusion tensor imaging sequences.
Kłodowski, Krzysztof; Krzyżak, Artur Tadeusz
2016-05-01
The paper describes a novel type of anisotropic phantoms designed for b-matrix spatial distribution diffusion tensor imaging (BSD-DTI). Cubic plate anisotropic phantom, cylinder capillary phantom and water reference phantom are described as a complete set necessary for calibration, validation and normalization of BSD-DTI. An innovative design of the phantoms basing on enclosing the anisotropic cores in glass balls filled with liquid made for the first time possible BSD calibration with usage of echo planar imaging (EPI) sequence. Susceptibility artifacts prone to occur in EPI sequences were visibly reduced in the central region of the phantoms. The phantoms were designed for usage in a clinical scanner's head coil, but can be scaled for other coil or scanner types. The phantoms can be also used for a pre-calibration of imaging of other types of phantoms having more specific applications. PMID:26707852
Gauge-invariant perturbations in anisotropic homogeneous cosmological models
International Nuclear Information System (INIS)
Perturbations in spatially flat anisotropic homogeneous cosmological models with arbitrary dimension N are classified into three types I, II, and III and gauge-invariant quantities are defined in each type. Equations for them are derived for arbitrary anisotropic flat models. It is found that density perturbations are described by two second-order differential equations, as in the treatment of Perko, Matzner, and Shepley for the pressureless fluid. The solutions are obtained for approximate Kasner-type anisotropic models and their characteristic behaviors are shown for the fluids with nonzero pressure as well as the pressureless fluid. They are consistent with the counterparts of Perko, Matzner, and Shepley for the pressureless fluid. The instability problem in a Kaluza-Klein multidimensional universe also is discussed
Thermodynamics and Instabilities of a Strongly Coupled Anisotropic Plasma
Mateos, David
2011-01-01
We extend our analysis of a IIB supergravity solution dual to a spatially anisotropic finite-temperature N=4 super Yang-Mills plasma. The solution is static, possesses an anisotropic horizon, and is completely regular. The full geometry can be viewed as a renormalization group flow from an AdS geometry in the ultraviolet to a Lifshitz-like geometry in the infrared. The anisotropy can be equivalently understood as resulting from a position-dependent theta-term or from a non-zero number density of dissolved D7-branes. The holographic stress tensor is conserved and anisotropic. The presence of a conformal anomaly plays an important role in the thermodynamics. The phase diagram exhibits homogeneous and inhomogeneous (i.e. mixed) phases. In some regions the homogeneous phase displays instabilities reminiscent of those of weakly coupled plasmas. We comment on similarities with QCD at finite baryon density and with the phenomenon of cavitation.
Stochastic Loewner evolution relates anomalous diffusion and anisotropic percolation
Credidio, Heitor F.; Moreira, André A.; Herrmann, Hans J.; Andrade, José S.
2016-04-01
We disclose the origin of anisotropic percolation perimeters in terms of the stochastic Loewner evolution (SLE) process. Precisely, our results from extensive numerical simulations indicate that the perimeters of multilayered and directed percolation clusters at criticality are the scaling limits of the Loewner evolution of an anomalous Brownian motion, being superdiffusive and subdiffusive, respectively. The connection between anomalous diffusion and fractal anisotropy is further tested by using long-range power-law correlated time series (fractional Brownian motion) as the driving functions in the evolution process. The fact that the resulting traces are distinctively anisotropic corroborates our hypothesis. Under the conceptual framework of SLE, our study therefore reveals different perspectives for mathematical and physical interpretations of non-Markovian processes in terms of anisotropic paths at criticality and vice versa.
Anisotropic spreading of liquid metal on a rough intermetallic surface
Directory of Open Access Journals (Sweden)
Liu Wen
2011-01-01
Full Text Available An anisotropic wicking of molten Sn-Pb solder over an intermetallic rough surface has been studied. The phenomenon features preferential spreading and forming of an elliptical spread domain. A theoretically formulated model was established to predict the ratio of the wicking distance along the long axis (rx to that along the short axis (ry of the final wicking pattern. The phenomenon was simultaneously experimentally observed and recorded with a hotstage microscopy technique. The anisotropic wicking is established to be caused by a non-uniform topography of surface micro structures as opposed to an isotropic wicking on an intermetallic surface with uniformly distributed surface micro features. The relative deviation between the theoretically predicted rx/ry ratio and the corresponding average experimental value is 5%. Hence, the small margin of error confirms the validity of the proposed theoretical model of anisotropic wicking.
The Derived Equivalent Circuit Model for Magnetized Anisotropic Graphene
Cao, Ying S; Ruehli, Albert E
2015-01-01
Due to the static magnetic field, the conductivity for graphene becomes a dispersive and anisotropic tensor, which complicates most modeling methodologies. In this paper, a novel equivalent circuit model is proposed for graphene with the magnetostatic bias based on the electric field integral equation (EFIE). To characterize the anisotropic property of the biased graphene, the resistive part of the unit circuit is replaced by a resistor in series with current control voltage sources (CCVSs). The CCVSs account for the off-diagonal parts of the surface conductivity tensor for the magnetized graphene. Furthermore, the definitions of the absorption cross section and the scattering cross section are revisited to make them feasible for derived circuit analysis. This proposed method is benchmarked with several numerical examples. This paper also provides a new equivalent circuit model to deal with dispersive and anisotropic materials.
Geodesic acoustic mode in anisotropic plasma with heat flux
International Nuclear Information System (INIS)
Geodesic acoustic mode (GAM) in an anisotropic tokamak plasma is investigated in fluid approximation. The collisionless anisotropic plasma is described within the 16-momentum magnetohydrodynamic (MHD) fluid closure model, which takes into account not only the pressure anisotropy but also the anisotropic heat flux. It is shown that the GAM frequency agrees better with the kinetic result than the standard Chew-Goldberger-Low (CGL) MHD model. When zeroing the anisotropy, the 16-momentum result is identical with the kinetic one to the order of 1/q2, while the CGL result agrees with the kinetic result only on the leading order. The discrepancies between the results of the CGL fluid model and the kinetic theory are well removed by considering the heat flux effect in the fluid approximation
Anisotropic fluids with two-perfect-fluid components
International Nuclear Information System (INIS)
A two-perfect-fluid model of an anisotropic fluid is presented. The energy-momentum tensor associated with the sum of two perfect fluids, one perfect and one null fluid, and two null fluids is examined. Special attention is devoted to the study of the stress tensor. The special case wherein the two perfect fluids are irrotational is studied. A relation between the Einstein equations for this particular case and the Einstein equations for a massless complex scalar field is found. The general solution of Einstein equations for an anisotropic fluid constructed with two-null-fluid components in the plane-symmetric case is discussed. The energy-momentum tensor of a cloud of strings and the energy-momentum tensor of an anisotropic fluid formed by two null fluids are compared
Analytical solutions of transport problems in anisotropic media
International Nuclear Information System (INIS)
Recently, the problem of neutron transport in anisotropic media has received new attention in connection with safety studies of water reactors and design of gas-cooled systems. In situations presenting large voided regions, as the axial streaming is dominating with respect to the transverse one, the average properties of the homogenized material should physically account for such macroscopic anisotropy. Hence, it is suggested that cell calculations produce anisotropic average cross sections, e.g., axial (σA) and transverse (σT) values. Since material anisotropy is due to leakage, as a first-step approximation, the medium can be considered isotropic with respect to scattering phenomena. Transport codes are currently being adapted to include anisotropic cross sections. An important aspect of code development is the validation of algorithms by analytical benchmarks. For that purpose, the present work is devoted to the fully analytical solution of transport problems in slab geometry
Debonding Analyses in Anisotropic Materials with Strain-Gradient Effects
DEFF Research Database (Denmark)
Legarth, Brian Nyvang
2012-01-01
A unit cell approach is adopted to numerically analyze the effect of plastic anisotropy on damage evolution in a microreinforced composite. The matrix material exhibit size effects and a visco-plastic anisotropic strain gradient plasticity model accounting for such size effects is adopted. A...... conventional cohesive law is extended such that both the average as well as the jump in plastic strain across the fiber-matrix interface are accounted for. Results are shown for both conventional isotropic and anisotropic materials as well as for higher order isotropic and anisotropic materials with and...... without debonding. Generally, the strain gradient enhanced material exhibits higher load carry capacity compared to the corresponding conventional material. A sudden stress drop occurs in the macroscopic stress-strain response curve due to fiber-matrix debonding and the results show that a change in yield...
Investigation of Porosity Evolution and Orthotropic Axes on Anisotropic Materials
Rahimi, Raheleh Mohammad
Advancement of porosities that happens in shear deformation of anisotropic materials is investigated by Dr. Kweon. As the hydrostatic stress in shear deformation is zero, in the solid mechanics' researches it is proved several times that porosity will not be expanded in shear deformation. Dr. Kweon showed that this statement can be wrong in large deformation of simple shear. He proposed anisotropic ductile fracture model to show that hydrostatic stress becomes nonzero and porosities are increased in the simple shear deformation of anisotropic materials. This study investigates the effect of the evolution of anisotropy which means the rotation of the orthotropic axes onto the porosity changes. Hill coefficient shows that how orthotropic materials indicate different ductile fracture manners in shear deformation. Also the effect of void aspect ratio on change of porosity is investigated. It has been found that the interaction among porosity, the matrix anisotropy and void aspect ratio play a crucial role in the ductile damage of porous materials.
Geodesic acoustic mode in anisotropic plasma with heat flux
Energy Technology Data Exchange (ETDEWEB)
Ren, Haijun, E-mail: hjren@ustc.edu.cn [CAS Key Laboratory of Geospace Environment and Department of Modern Physics, University of Science and Technology of China, Hefei 230026 (China)
2015-10-15
Geodesic acoustic mode (GAM) in an anisotropic tokamak plasma is investigated in fluid approximation. The collisionless anisotropic plasma is described within the 16-momentum magnetohydrodynamic (MHD) fluid closure model, which takes into account not only the pressure anisotropy but also the anisotropic heat flux. It is shown that the GAM frequency agrees better with the kinetic result than the standard Chew-Goldberger-Low (CGL) MHD model. When zeroing the anisotropy, the 16-momentum result is identical with the kinetic one to the order of 1/q{sup 2}, while the CGL result agrees with the kinetic result only on the leading order. The discrepancies between the results of the CGL fluid model and the kinetic theory are well removed by considering the heat flux effect in the fluid approximation.
Anisotropic Chemical Reactor with Correlation Spectroscopic Control of Nanoparticles Size
Directory of Open Access Journals (Sweden)
A.G. Lazarenko
2014-04-01
Full Text Available This paper proposes a new kind of chemical reactor for nanoparticles synthesis with real-time control of size by correlation spectroscopy methods. The liquid pumping in the reactor is attained by a heater and / or cooler anisotropic placing in a reactor with a bath consisting of two communicating vessels connected by two tubes with transparent portion. When driving the fluid through the transparent area of the narrowed tube particle size is measured by a sensor or sensors. To increase the speed of cyclic movement and mixing of liquid the chemical rector can be supplemented with a mechanical stirrer also anisotropic in shape.
Surface waves in ﬁbre-reinforced anisotropic elastic media
Indian Academy of Sciences (India)
P R Sengupta; Sisir Nath
2001-08-01
The aim of this paper is to investigate surface waves in anisotropic ﬁbre-reinforced solid elastic media. First, the theory of general surface waves has been derived and applied to study the particular cases of surface waves – Rayleigh, Love and Stoneley types. The wave velocity equations are found to be in agreement with the corresponding classical result when the anisotropic elastic parameters tends to zero. It is important to note that the Rayleigh type of wave velocity in the ﬁbre-reinforced elastic medium increases to a considerable amount in comparison with the Rayleigh wave velocity in isotropic materials.
Behavior of chaotic inflation in anisotropic cosmologies with nonminimal coupling
Energy Technology Data Exchange (ETDEWEB)
Futamase, T.; Rothman, T.; Matzner, R.
1989-01-15
We review the behavior of the chaotic inflationary scenario in the minimally coupled anisotropic case and in the nonminimally coupled isotropic case. In the former, anisotropy enhances inflation. In the latter, positive nonminimal coupling introduces a singularity at a critical point phi-circumflex/sub c/ in the scalar field. The exact value of phi-circumflex/sub c/ depends on the coupling parameter xi. This singularity cannot be exceeded, which precludes astrophysically sufficient inflation for xiapprox. >10/sup -2/. We extend the analysis to anisotropic Bianchi models where a second singularity phi/sub c/ appears, which further prevents inflation in these models for xiapprox. >10/sup -2/.
Electric fields inside and outside an anisotropic dielectric sphere
Institute of Scientific and Technical Information of China (English)
Li Ying-Le; Wang Ming-Jun
2009-01-01
Analytical expressions of electric fields inside and outside an anisotropic dielectric sphere are presented by transforming an anisotropic medium into an isotropic one based on the multi-scale transformation of electromagnetic theory.The theoretical expressions are consistent with those in the literature. The inside electric field, the outside electric field and the angle between their directions are derived in detail. Numerical simulations show that the direction of the outside field influences the magnitude of the inside field, while the dielectric constant tensor greatly affects its direction.
MHz Gravitational Waves from Short-term Anisotropic Inflation
Ito, Asuka
2016-01-01
We reveal the universality of short-term anisotropic inflation. As a demonstration, we study inflation with an exponential type gauge kinetic function which is ubiquitous in models obtained by dimensional reduction from higher dimensional fundamental theory. It turns out that an anisotropic inflation universally takes place in the later stage of conventional inflation. Remarkably, we find that primordial gravitational waves with a peak amplitude around $10^{-26}$ ~ $10^{-27}$ are copiously produced in high-frequency bands 10MHz~100MHz. If we could detect such gravitational waves in future, we would be able to probe higher dimensional fundamental theory.
Tunable waveguide bends with graphene-based anisotropic metamaterials
Chen, Zhao-xian
2016-01-15
We design tunable waveguide bends filled with graphene-based anisotropic metamaterials to achieve a nearly perfect bending effect. The anisotropic properties of the metamaterials can be described by the effective medium theory. The nearly perfect bending effect is demonstrated by finite element simulations of various structures with different bending curvatures and shapes. This effect is attributed to zero effective permittivity along the direction of propagation and matched effective impedance at the interfaces between the bending part and the dielectric waveguides. We envisage that the design will be applicable in the far-infrared and terahertz frequency ranges owing to the tunable dielectric responses of graphene.
Hysteresis modeling of anisotropic and isotropic nanocrystalline hard magnetic films
Cornejo, D. R.; Azevedo, A.; Rezende, S. M.
2003-05-01
In the Hauser model, the magnetic state of a system is obtained by minimizing the so-called total energy function for a statistical set of magnetic domains. In this article, this energetic model of ferromagnetic materials is used in order to calculate hysteresis loops of isotropic and anisotropic nanocrystalline SmCo films at room temperature. A qualitative very good agreement between the calculated and experimental curves is obtained, mainly in the anisotropic case. Also, it has been verified that, under suitable approximations, the free parameters of the model can tie with intrinsic characteristics of the reversal magnetization process.
Casimir force between parallel plates separated by anisotropic media
Deng, Gang; Tan, Bao-Hua; Pei, Ling; Hu, Ni; Zhu, Jin-Rong
2015-06-01
The Casimir force between two parallel plates separated by anisotropic media is investigated. We theoretically calculate the Casimir force between two parallel plates when the interspace between the plates is filled with anisotropic media. Our result shows that the anisotropy of the material between the plates can significantly affect the Casimir force, especially the direction of the force. If ignoring the anisotropy of the in-between material makes the force repulsive (attractive), by contrast taking the anisotropy into account may produce an extra attractive (repulsive) force. The physical explanation for this phenomenon is also discussed.
Electric double layer of anisotropic dielectric colloids under electric fields
Han, M.; Wu, H.; Luijten, E.
2016-07-01
Anisotropic colloidal particles constitute an important class of building blocks for self-assembly directed by electrical fields. The aggregation of these building blocks is driven by induced dipole moments, which arise from an interplay between dielectric effects and the electric double layer. For particles that are anisotropic in shape, charge distribution, and dielectric properties, calculation of the electric double layer requires coupling of the ionic dynamics to a Poisson solver. We apply recently proposed methods to solve this problem for experimentally employed colloids in static and time-dependent electric fields. This allows us to predict the effects of field strength and frequency on the colloidal properties.
The anisotropic \\lambda-deformed SU(2) model is integrable
Sfetsos, Konstantinos
2014-01-01
The all-loop anisotropic Thirring model interpolates between the WZW model and the non-Abelian T-dual of the anisotropic principal chiral model. We focus on the SU(2) case and we prove that it is classically integrable by providing its Lax pair formulation. We derive its underlying symmetry current algebra and use it to show that the Poisson brackets of the spatial part of the Lax pair, assume the Maillet form. In this way we procure the corresponding r and s matrices which provide non-trivial solutions to the modified Yang-Baxter equation.
Specular nonlinear anisotropic polarization effect along fourfold crystal symmetry axes
Bungay, A.R.; Popov, S. V.; N. I. Zheludev; Svirko, Y.P.
1995-01-01
We present what is to our knowledge the first experimental observation of the specular nonlinear anisotropic polarization effect of a pump-induced polarization-plane rotation for normal-incidence reflection from the (001) surface of a cubic crystal. In GaAs, azimuth rotation of the order of 9 × 10^-6 rad is seen for a pump intensity of 75 MW/cm^-2 at 750 nm, from which the anisotropic component of the cubic nonlinearity |Re(?xxxx ? 2?xxyy ? ?xyyx)| = 5 × 10^-9 esu is found.
Nonlinear dynamic analysis of quasi-symmetric anisotropic structures
Noor, Ahmed K.; Peters, Jeanne M.
1987-01-01
An efficient computational method for the nonlinear dynamic analysis of quasi-symmetric anisotropic structures is proposed. The application of mixed models simplifies the analytical development and improves the accuracy of the response predictions, and operator splitting allows the reduction of the analysis model of the quasi-symmetric structure to that of the corresponding symmetric structure. The preconditoned conjugate gradient provides a stable and effective technique for generating the unsymmetric response of the structure as the sum of a symmetrized response plus correction modes. The effectiveness of the strategy is demonstrated with the example of a laminated anisotropic shallow shell of quadrilateral planform subjected to uniform normal loading.
Phase Space of Anisotropic $R^n$ Cosmologies
Leon, Genly
2014-01-01
We construct general anisotropic cosmological scenarios governed by an $f(R)=R^n$ gravitational sector. Focusing then on some specific geometries, and modelling the matter content as a perfect fluid, we perform a phase-space analysis. We analyze the possibility of accelerating expansion at late times, and additionally, we determine conditions for the parameter $n$ for the existence of phantom behavior, contracting solutions as well as of cyclic cosmology. Furthermore, we analyze if the universe evolves towards the future isotropization without relying on a cosmic no-hair theorem. Our results indicate that anisotropic geometries in modified gravitational frameworks present radically different cosmological behaviors compared to the simple isotropic scenarios.
Anisotropic mass density by radially periodic fluid structures.
Torrent, Daniel; Sánchez-Dehesa, José
2010-10-22
This Letter reports physical realization of acoustic metamaterials with anisotropic mass density. These metamaterials consist of a superlattice of two fluidlike components radially periodic. Several structures are spectroscopically characterized at large wavelengths (homogenization limit) by studying the acoustic resonances existing in the circular cavity where they are embedded. This characterization method allows us to extract the diagonal components of the sound speed tensor. Analytical expressions describing the anisotropic behavior as a function of the corrugation parameter are also developed and their predictions are in agreement with measurements. PMID:21231048
Propagation of shock wave fronts in anisotrope layered media
International Nuclear Information System (INIS)
Propagation of shock waves in layered anisotropic tectonic media is associated with their fronts transformation, scattering, bifurcation and focussing. To investigate these phenomena, a technique based on joint usage of ray theory and theory of stereomechanical impact is elaborated. It is used for computer simulation of dynamical interaction of shock waves with curvilinear interfaces between anisotropic elastic media. Issues are considered which are related to the shock waves fronts surfaces bifurcations and generation of caustics connected with stress concentration and formation of zones where the stresses tend to infinity
Czech Academy of Sciences Publication Activity Database
Červený, V.; Pšenčík, Ivan
2015-01-01
Roč. 25, - (2015), s. 109-155. ISSN 2336-3827 Institutional support: RVO:67985530 Keywords : integral superposition of paraxial Gaussian beams * inhomogeneous anisotropic media * S waves in weakly anisotropic media Subject RIV: DC - Siesmology, Volcanology, Earth Structure
Development of Pore Pressure in Cohesionless Soils with Initial Shear Stresses during Cyclic Loading
DEFF Research Database (Denmark)
Ibsen, Lars Bo; Jacobsen, H. Moust
1989-01-01
A number of triaxial tests with the loading harmonically oscillating around an initial and anisotropic stress state have been performed. Hereby the influence of the initial shear stress on the development of pore pressure in a cohesionless sand specimen have been clarified. A simple theory...
Apoptosis in odontogenesis - a brief review
Nair, Bindu J
2010-01-01
Tooth formation is an excellent example of epithelial mesenchymal interaction As the developingtooth passes through the various morphologic stages it is observed that apoptosis occurs selectively incertain locations. Here a review is done to throw light into the role of apoptosis and the factorsgoverning the same during odontogenesis .
Apoptosis in odontogenesis - a brief review
Directory of Open Access Journals (Sweden)
Bindu J. Nair
2010-01-01
Full Text Available Tooth formation is an excellent example of epithelial mesenchymal interaction As the developingtooth passes through the various morphologic stages it is observed that apoptosis occurs selectively incertain locations. Here a review is done to throw light into the role of apoptosis and the factorsgoverning the same during odontogenesis .
Determinants of PDT-induced apoptosis
Kessel, David; Luo, Yu; Kim, Hyeong-Reh C.
2000-03-01
Photodynamic therapy can initiate cell death by apoptosis or necrosis. Using agents with known patterns of sub-cellular localization, we examined the correlation between sites of photodamage and the mode of cell death, using murine leukemia cells in vitro. Mitochondrial or mitochondrial/lysosomal photodamage caused the rapid release of cytochrome c. This effect was not temperature sensitive, and could be demonstrated immediately after irradiation of photosensitized cells at 10 degrees C. Subsequent warming to 37 degrees C led to a rapid apoptotic response, consistent with the known ability of cytochrome c to trigger the activation of caspase-3. In contrast, lysosomal or lysosomal/membrane photodamage resulted in the release of cathepsins and other proteolytic enzymes. A subsequent incubation at 37 degrees C resulted in mitochondrial degradation, leading to loss of cytochrome c within 30 min. The apoptotic response was both delayed and incomplete, with many dead cells not exhibiting an apoptotic morphology. The latter outcome was traced to photodamage to procaspase-3, an effect not observed with sensitizers that caused mainly mitochondrial photodamage. Studies in a cell-free system demonstrated that agents with lysosomal and/or membrane targets could bring about photoinactivation of caspase-3. These result are consistent with the proposal that photodynamic therapy can both activate and inactivate components of the apoptotic process.
Anisotropic Left-Handed and μ-Negative Slab Waveguides: Physics and Device Applications
2007-01-01
We study the properties of various anisotropic left-handed slab waveguides. The analysis is extended to anisotropic μ-negative slab waveguides. The possible existence of the plasmon modes in various anisotropic slab waveguide configurations is discussed. An FDTD program is developed to investigate the potential device applications of these anisotropic structures. A new signal detector and a two-channel harmonic separator multiplexer are designed employing the μ-negative slab waveguide.
A Morphing framework to couple non-local and local anisotropic continua
Azdoud, Yan
2013-05-01
In this article, we develop a method to couple anisotropic local continua with anisotropic non-local continua with central long-range forces. First, we describe anisotropic non-local models based on spherical harmonic descriptions. We then derive compatible classic continuum models. Finally, we apply the morphing method to these anisotropic non-local models and present three-dimensional numerical examples to validate the efficiency of the technique. © 2013 Elsevier Ltd. All rights reserved.
Ottosen, Thor-Bjørn
2008-01-01
This project is about rill erosion. The aim is to test whether rill initiation can be predicted from the shear strength of the soil as measured with a torvane on saturated soil. This approach was set forward by Rauws and Govers 1988. Rainfall simulation experiments are conducted at a plot size 2x1m, performed in May on the Marbjerg experimental field. The results are evaluated using a chain set to measure alterations of the surface roughness as a result of the erosion, visual evaluation of ph...
Anisotropic behaviour of human gallbladder walls
W.G. Li; Hill, N. A.; Ogden, R W; Smythe, A; Majeed, A.W.; Bird, N.; Luo, X. Y.
2013-01-01
Inverse estimation of biomechanical parameters of soft tissues from non-invasive measurements has clinical significance in patient-specific modelling and disease diagnosis. In this paper, we propose a fully nonlinear approach to estimate the mechanical properties of the human gallbladder wall muscles from in vivo ultrasound images. The iteration method consists of a forward approach, in which the constitutive equation is based on a modified Hozapfel–Gasser–Ogden law initially developed for ar...
Analysis of apoptosis in Caenorhabditis elegans.
Lant, Benjamin; Derry, W Brent
2014-05-01
The nematode worm Caenorhabditis elegans has provided researchers with a wealth of information on the molecular mechanisms controlling programmed cell death (apoptosis). Its genetic tractability, optical clarity, and relatively short lifespan are key advantages for rapid assessment of apoptosis in vivo. The use of forward and reverse genetics methodology, coupled with in vivo imaging, has provided deep insights into how a multicellular organism orchestrates the self-destruction of specific cells during development and in response to exogenous stresses. Strains of C. elegans carrying mutations in the core elements of the apoptotic pathway, or in tissue-specific regulators of apoptosis, can be used for genetic analyses to reveal conserved mechanisms by which apoptosis is regulated in the somatic and reproductive (germline) tissue. Here we present an introduction to the study of apoptosis in C. elegans, including current techniques for visualization, analysis, and screening. PMID:24786497
Apoptosis in normal oral tissues and odontogenesis
Directory of Open Access Journals (Sweden)
Ruchita Bali
2013-01-01
Full Text Available Programmed cell death or apoptosis is considered a vital component of various processes including normal cell turnover, proper development and functioning of the immune system, hormone-dependent atrophy, embryonic development, and chemical-induced cell death. Inappropriate apoptosis (either too little or too much is a factor in many human conditions including neurodegenerative diseases, ischemic damage, autoimmune disorders, and many types of cancers. The process of apoptosis is generally characterized by distinct morphological characteristics and energy-dependent biochemical mechanisms. An understanding of its role in the pathophysiology of oral tissues is pertinent to the development of novel therapeutic approaches. The developing tooth passes through the various morphologic stages and apoptosis is observed selectively in certain locations. This review focuses on the current knowledge of apoptosis emphasizing its role in normal oral tissues and odontogenesis.
Study of apoptosis in human liver cancers
Institute of Scientific and Technical Information of China (English)
Chang-Min Shan; Juan Li
2002-01-01
AIM: To investigate the action of apoptosis in occurrence ofliver cacinornas in vivo and the biological effect of Solanumlyratum Thumb on BEL-7404 cell line inducing apoptosis invitro.METHODS: The apoptosis in the liver carcinoma wasdetected with terminal deoxynucl neotidyl transferasemediated dUTP nick end labelling (TUNEL); the cancer cellscultured in DMED medium were treated with extract ofSolanum lyratum Thumb and observed under microscope,and their DNA was assayed by gel electrophoresis.RESULTS: In vivo apoptotic cells in the cancer adjacenttissues inceased; in vitro treatment of liver cancers withextract of Solanum lyratum Thumb could induce the cells tomanifest a typical apoptotic morphology. Their DNA wasfractured and a characteristic ladder pattem could be foundusing electrophoresis.CONCLUSION: In vivo the apoptosis of carcinomas waslower; maybe the cells divided quickly and then the cancersoccurred. In the cancer adjacent tissues, the apoptosispricked up, and in vitro Solarium lyratum Thumb couldinduce the apoptosis of BEL-7404 cells.
In vivo nuclear imaging of apoptosis
International Nuclear Information System (INIS)
Apoptosis plays a role in the pathophysiology of many kinds of diseases and in the response of treatment. Compared to the necrosis, the apoptosis a genetically controlled and energy-dependent process which removes the unwanted cells from the body; programmed cell death or cell suicide. During the apoptosis, phosphatidylserine is expressed in the cytoplasmic outer membrane in the early phase. Annexin V, an endogenous human protein (MW=35 kD), has an affinity of about 10-9 M for the phosphatidylserine exposed on the outer membrane of apoptotic cells. Annexin V can be radiolabeled with 99mTc by HYNIC or EC chelators, which can be used as an radiotracer for the in vivo imaging of apoptosis. In this article, we reviewed the apoptosis, radiolabeling of annexin V, and the experimental and clinical data using annexin V imaging
In vivo nuclear imaging of apoptosis
Energy Technology Data Exchange (ETDEWEB)
Lee, Tae Sup; Cheon, Gi Jeong [Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of)
2004-04-01
Apoptosis plays a role in the pathophysiology of many kinds of diseases and in the response of treatment. Compared to the necrosis, the apoptosis a genetically controlled and energy-dependent process which removes the unwanted cells from the body; programmed cell death or cell suicide. During the apoptosis, phosphatidylserine is expressed in the cytoplasmic outer membrane in the early phase. Annexin V, an endogenous human protein (MW=35 kD), has an affinity of about 10{sup -9} M for the phosphatidylserine exposed on the outer membrane of apoptotic cells. Annexin V can be radiolabeled with {sup 99}mTc by HYNIC or EC chelators, which can be used as an radiotracer for the in vivo imaging of apoptosis. In this article, we reviewed the apoptosis, radiolabeling of annexin V, and the experimental and clinical data using annexin V imaging.
International Nuclear Information System (INIS)
We carried out three-dimensional magnetohydrodynamic simulations to study the effects of plasma viscosity on the formation of sharp discontinuities of density and temperature distributions, cold fronts, in clusters of galaxies. By fixing the gravitational potential that confines the cool, dense plasma in a moving subcluster, we simulated its interaction with the hot, lower density plasma around the subcluster. At the initial state, the intracluster medium (ICM) is assumed to be threaded by uniform magnetic fields. The enhancement of plasma viscosity along the direction of magnetic fields is incorporated as anisotropic viscosity depending on the direction of magnetic fields. We found that the Kelvin-Helmholtz instability at the surface of the subcluster grows even in models with anisotropic viscosity, because its effects on the velocity shear across the magnetic field lines are suppressed. We also found that magnetic fields around the interface between the subcluster and ICM are amplified even in the presence of viscosity, while magnetic fields behind the subcluster are amplified up to β–1 ∼ 0.01 in models with viscosity, whereas they are amplified up to β–1 ∼ 0.1 in models without viscosity, where β is the ratio of gas pressure to magnetic pressure.
Electrospun PCL nanofibers with anisotropic mechanical properties as a biomedical scaffold
International Nuclear Information System (INIS)
To design an ideal scaffold, various factors should be considered, such as pore size and morphology, mechanical properties versus porosity, surface properties and appropriate biodegradability. Of these factors, the importance of mechanical properties on cell growth is particularly obvious in tissues such as bone, cartilage, blood vessels, tendons and muscles. Although electrospun nanofibers provide easily applicable nano-sized structures which could be used as biomedical scaffolds, the mechanical properties are poor since an increased pore size and porosity are generally accompanied by a decrease in mechanical properties. In addition, the general electrospinning has been limited to the fabrication of a variety of anisotropic mechanical properties, which are extremely important parameters for designing a musculoskeletal system. In this study, scaffolds consisting of variously oriented nanofibers were produced using an electrospinning process modified with an auxiliary electrode and a two-axis robot collecting system. Using an auxiliary electrode, a stable Taylor cone and initial spun jets were obtained. The influence of the electrode was evaluated with electric field simulation. Using the modified electrospinning process, various directions of orientation of electrospun fibers could be acquired and the fabricated oriented nanofiber webs showed a mechanically anisotropic behavior and a higher hydrophilic property compared to randomly distributed fibrous mats
Short intergranular cracks in the piecewise anisotropic continuum model of the microstructure
International Nuclear Information System (INIS)
Computational algorithms aiming at modeling and visualization of the initiation and growth of intergranular stress corrosion cracks (e.g., in the steam generator tubes) on the grain-size scale have already been proposed [6]. The main focus of the paper is given to the influence of randomly oriented neighboring grains on the microscopic stress fields at crack tips. The incompatibility strains, which develop along the boundaries of randomly oriented anisotropic grains, are shown to influence the local stress fields at crack tips significantly. Special attention has been paid to the implementation and comparison of different numerical methods estimating the local stress fields at crack tips, aiming at optimizing the computational time and the numerical accuracy of the results. The limited number of calculations indicate that the anisotropic arrangement of grains with local incompatibility strains causes on average about 10% (plane strain) and 26% (plane stress) higher J-integral values at the crack tips than expected from the calculations in the isotropic case.(author)
Electrospun PCL nanofibers with anisotropic mechanical properties as a biomedical scaffold
Energy Technology Data Exchange (ETDEWEB)
Kim, Geun Hyung [Department of Mechanical Engineering, Chosun University, 375 Seosok-dong, Dong-gu, Kwangju (Korea, Republic of)], E-mail: gkim@chosun.ac.kr
2008-06-01
To design an ideal scaffold, various factors should be considered, such as pore size and morphology, mechanical properties versus porosity, surface properties and appropriate biodegradability. Of these factors, the importance of mechanical properties on cell growth is particularly obvious in tissues such as bone, cartilage, blood vessels, tendons and muscles. Although electrospun nanofibers provide easily applicable nano-sized structures which could be used as biomedical scaffolds, the mechanical properties are poor since an increased pore size and porosity are generally accompanied by a decrease in mechanical properties. In addition, the general electrospinning has been limited to the fabrication of a variety of anisotropic mechanical properties, which are extremely important parameters for designing a musculoskeletal system. In this study, scaffolds consisting of variously oriented nanofibers were produced using an electrospinning process modified with an auxiliary electrode and a two-axis robot collecting system. Using an auxiliary electrode, a stable Taylor cone and initial spun jets were obtained. The influence of the electrode was evaluated with electric field simulation. Using the modified electrospinning process, various directions of orientation of electrospun fibers could be acquired and the fabricated oriented nanofiber webs showed a mechanically anisotropic behavior and a higher hydrophilic property compared to randomly distributed fibrous mats.
International Nuclear Information System (INIS)
Dysregulation of apoptosis is involved in a wide spectrum of disease ranging from proliferative to degenerative disorders. An emerging area of study in apoptosis is the critical contribution of the endoplasmic reticulum (ER) in both mitochondrial and ER specific apoptosis pathways. Here we show that brefeldin A and tunicamycin-mediated ER stress lead to caspase-dependent apoptosis involving caspase-2. Confocal microscopy and subcellular fractionation indicate that caspase-2 is localized to the ER, and following ER stress, the processing of caspase-2 and -9 is an early event preceding the activation of caspase-3 and -7 and the cleavage of the caspase substrate poly(ADP-ribose) polymerase (PARP). Inhibition and silencing of either caspase-2 or caspase-9 suppress ER stress-induced apoptosis, as demonstrated by annexin V binding. Similarly, transduction with an adenovirus encoding either Inhibitors of Apoptosis (IAP) protein HIAP1/c-IAP2 or HIAP2/c-IAP1 also suppresses ER stress-induced apoptosis. However, among HIAP1, HIAP2 and XIAP, only HIAP2 binds and inhibits caspase-2. Our results thus indicate a novel mechanism by which HIAP2 can regulate ER-initiated apoptosis by modulating the activity of caspase-2
Directory of Open Access Journals (Sweden)
Zhi Pan
2014-02-01
Full Text Available Previously, we reported that endoplasmic reticulum calcium stores were a direct target for paclitaxel initiation of apoptosis. Furthermore, the actions of paclitaxel attenuated Bcl-2 resistance to apoptosis through endoplasmic reticulum-mediated calcium release. To better understand the calcium-regulated mechanisms of paclitaxel-induced apoptosis in breast cancer cells, we investigated the role of extracellular calcium, specifically; whether influx of extracellular calcium contributed to and/or was necessary for paclitaxel-induced apoptosis. Our results demonstrated that paclitaxel induced extracellular calcium influx. This mobilization of extracellular calcium contributed to subsequent cytosolic calcium elevation differently, depending on dosage. Under normal extracellular calcium conditions, high dose paclitaxel induced apoptosis-promoting calcium influx, which did not occur in calcium-free conditions. In the absence of extracellular calcium an “Enhanced Calcium Efflux” mechanism in which high dose paclitaxel stimulated calcium efflux immediately, leading to dramatic cytosolic calcium decrease, was observed. In the absence of extracellular calcium, high dose paclitaxel’s stimulatory effects on capacitative calcium entry and apoptosis could not be completely restored. Thus, normal extracellular calcium concentrations are critical for high dose paclitaxel-induced apoptosis. In contrast, low dose paclitaxel mirrored controls, indicating that it occurs independent of extracellular calcium. Thus, extracellular calcium conditions only affect efficacy of high dose paclitaxel-induced apoptosis.
Lymphocyte apoptosis in murine Pneumocystis pneumonia
Directory of Open Access Journals (Sweden)
Ruan Sanbao
2009-06-01
Full Text Available Abstract Background Apoptosis of lymphocytes is important in the termination of an immune response to infection but has also been shown to have detrimental effects in animal models of systemic infection and sepsis. We sought to characterize lymphocyte apoptosis in an animal model of pneumonia due to Pneumocystis murina, an infection localized to the lungs. Methods Control mice and mice depleted of CD4+ lymphocytes were inoculated with Pneumocystis. Apoptosis of lung and spleen lymphocytes was assayed by flow cytometry and PCR assay of apoptotic proteins. Results In control mice, apoptosis of lung lymphocytes was maximal just after the infection was cleared from lung tissue and then declined. However, in CD4-depleted mice, apoptosis was also upregulated in recruited lymphocytes in spite of progressive infection. In splenic lymphocytes, apoptosis was observed early at 1 week after inoculation and then declined. Apoptosis of lung lymphocytes in control mice was associated with a decrease in mRNA for Bcl-2 and an increase in mRNA for Bim. In CD4-depleted mice, lavaged CD8+ cells did change intracellular Bcl-2 but showed increased mRNA for Bim. Conclusion Apoptosis of both pulmonary and extrapulmonary lymphocytes is part of the normal host response to Pneumocystis but is also triggered in CD4-deficient animals with progressive infection. In normal mice apoptosis of pulmonary lymphocytes may serve to terminate the immune response in lung tissue. Apoptosis of lung lymphocytes takes place via both the intrinsic and extrinsic apoptotic pathways and is associated with changes in both pro- and anti-apoptotic proteins.
Polarization conversion-based molecular sensing using anisotropic plasmonic metasurfaces
Verre, R.; Maccaferri, N.; Fleischer, K.; Svedendahl, M.; Odebo Länk, N.; Dmitriev, A.; Vavassori, P.; Shvets, I. V.; Käll, M.
2016-05-01
Anisotropic media induce changes in the polarization state of transmitted and reflected light. Here we combine this effect with the refractive index sensitivity typical of plasmonic nanoparticles to experimentally demonstrate self-referenced single wavelength refractometric sensing based on polarization conversion. We fabricated anisotropic plasmonic metasurfaces composed of gold dimers and, as a proof of principle, measured the changes in the rotation of light polarization induced by biomolecular adsorption with a surface sensitivity of 0.2 ng cm-2. We demonstrate the possibility of miniaturized sensing and we show that experimental results can be reproduced by analytical theory. Various ways to increase the sensitivity and applicability of the sensing scheme are discussed.Anisotropic media induce changes in the polarization state of transmitted and reflected light. Here we combine this effect with the refractive index sensitivity typical of plasmonic nanoparticles to experimentally demonstrate self-referenced single wavelength refractometric sensing based on polarization conversion. We fabricated anisotropic plasmonic metasurfaces composed of gold dimers and, as a proof of principle, measured the changes in the rotation of light polarization induced by biomolecular adsorption with a surface sensitivity of 0.2 ng cm-2. We demonstrate the possibility of miniaturized sensing and we show that experimental results can be reproduced by analytical theory. Various ways to increase the sensitivity and applicability of the sensing scheme are discussed. Electronic supplementary information (ESI) available. See DOI: 10.1039/c6nr01336h
Anisotropic cosmological models and generalized scalar tensor theory
Indian Academy of Sciences (India)
Subenoy Chakraborty; Batul Chandra Santra; Nabajit Chakravarty
2003-10-01
In this paper generalized scalar tensor theory has been considered in the background of anisotropic cosmological models, namely, axially symmetric Bianchi-I, Bianchi-III and Kortowski–Sachs space-time. For bulk viscous ﬂuid, both exponential and power-law solutions have been studied and some assumptions among the physical parameters and solutions have been discussed.
Plasma resonance in anisotropic layered high-Tc superconductors
DEFF Research Database (Denmark)
Sakai, Shigeki; Pedersen, Niels Falsig
1999-01-01
The plasma resonance is described theoretically by the inductive coupling model for a large stacked Josephson-junction system such as the intrinsic Josephson-junction array in anisotropic high- T-c superconductors. Eigenmodes of the plasma oscillation are analytically described and a numerical...
Spectral magnetotelluric impedances for an anisotropic layered conductor
Czech Academy of Sciences Publication Activity Database
Pek, Josef
2002-01-01
Roč. 50, č. 4 (2002), s. 619-643. ISSN 0001-5725 R&D Projects: GA ČR GA205/99/0917; GA MŠk ME 185 Institutional research plan: CEZ:AV0Z3012916 Keywords : magnetotelluric impedance * anisotropic conductor * electromagnetic induction Subject RIV: DE - Earth Magnetism, Geodesy, Geography
Mathematical model of non-isothermal creep based anisotropic damage
Галаган, Ю. Н.; Лысенко, С. В.; Львов, Г. И.
2008-01-01
А mathematical model of nonisothermic creep for anisotropic damage case is considered. Constitutive relation of creep rate and kinematic equation of damage evolution are assumed temperature dependent. A second range tensor is used for description damage. A technique based on existing experimental curves for the identification of material creep constants is presented.
Vertical Flow Lithography for Fabrication of 3D Anisotropic Particles.
Habasaki, Shohei; Lee, Won Chul; Yoshida, Shotaro; Takeuchi, Shoji
2015-12-22
A microfluidics-based method for the 3D fabrication of anisotropic particles is reported. The method uses a vertical microchannel where tunable light patterns solidify photocurable resins for stacking multiple layers of the resins, thus enabling an application of stereolithography concepts to conventional flow lithography. Multilayered, tapered, and angular compartmental microparticles are demonstrated. PMID:26551590
Highly anisotropic and robust excitons in monolayer black phosphorus.
Wang, Xiaomu; Jones, Aaron M; Seyler, Kyle L; Tran, Vy; Jia, Yichen; Zhao, Huan; Wang, Han; Yang, Li; Xu, Xiaodong; Xia, Fengnian
2015-06-01
Semi-metallic graphene and semiconducting monolayer transition-metal dichalcogenides are the most intensively studied two-dimensional materials of recent years. Lately, black phosphorus has emerged as a promising new two-dimensional material due to its widely tunable and direct bandgap, high carrier mobility and remarkable in-plane anisotropic electrical, optical and phonon properties. However, current progress is primarily limited to its thin-film form. Here, we reveal highly anisotropic and strongly bound excitons in monolayer black phosphorus using polarization-resolved photoluminescence measurements at room temperature. We show that, regardless of the excitation laser polarization, the emitted light from the monolayer is linearly polarized along the light effective mass direction and centres around 1.3 eV, a clear signature of emission from highly anisotropic bright excitons. Moreover, photoluminescence excitation spectroscopy suggests a quasiparticle bandgap of 2.2 eV, from which we estimate an exciton binding energy of ∼0.9 eV, consistent with theoretical results based on first principles. The experimental observation of highly anisotropic, bright excitons with large binding energy not only opens avenues for the future explorations of many-electron physics in this unusual two-dimensional material, but also suggests its promising future in optoelectronic devices. PMID:25915195
Three anisotropic benchmark problems for adaptive finite element methods
Czech Academy of Sciences Publication Activity Database
Šolín, Pavel; Čertík, O.; Korous, L.
2013-01-01
Roč. 219, č. 13 (2013), s. 7286-7295. ISSN 0096-3003 R&D Projects: GA AV ČR IAA100760702 Institutional support: RVO:61388998 Keywords : benchmark problem * anisotropic solution * boundary layer Subject RIV: BA - General Mathematics Impact factor: 1.600, year: 2013
A new noise erosion operator for anisotropic diffusion
Institute of Scientific and Technical Information of China (English)
蔡超; 丁名跃; 周成平; 张天序
2004-01-01
A noise erosion operator based on partial differential equation (PDE) is introduced, which has an excellent ability of noise removal and edge preservation for two-dimensional (2D) gradient data. The operator is applied to estimate a new diffusion coefficient. Experimental results demonstrate that anisotropic diffusion based on this new erosion operator can efficiently reduce noise and sharpen object boundaries.
Prestack exploding reflector modelling and migration for anisotropic media
Alkhalifah, Tariq Ali
2014-10-09
The double-square-root equation is commonly used to image data by downward continuation using one-way depth extrapolation methods. A two-way time extrapolation of the double-square-root-derived phase operator allows for up and downgoing wavefields but suffers from an essential singularity for horizontally travelling waves. This singularity is also associated with an anisotropic version of the double-square-root extrapolator. Perturbation theory allows us to separate the isotropic contribution, as well as the singularity, from the anisotropic contribution to the operator. As a result, the anisotropic residual operator is free from such singularities and can be applied as a stand alone operator to correct for anisotropy. We can apply the residual anisotropy operator even if the original prestack wavefield was obtained using, for example, reverse-time migration. The residual correction is also useful for anisotropic parameter estimation. Applications to synthetic data demonstrate the accuracy of the new prestack modelling and migration approach. It also proves useful in approximately imaging the Vertical Transverse Isotropic Marmousi model.
Influence of anisotropic piezoelectric actuators on wing aerodynamic forces
Institute of Scientific and Technical Information of China (English)
GUAN De; LI Min; LI Wei; WANG MingChun
2008-01-01
Changing the shape of an airfoil to enhance overall aircraft performance has always been s goal of aircraft designers.Using smart material to reshape the wing can improve aerodynamic performance.The influence of anisotropic effects of piezo-electric actuators on the aerodynamic characteristics of a simplified HALE wing model was investigated.Test verification was conducted.
Influence of anisotropic piezoelectric actuators on wing aerodynamic forces
Institute of Scientific and Technical Information of China (English)
2008-01-01
Changing the shape of an airfoil to enhance overall aircraft performance has always been a goal of aircraft designers. Using smart material to reshape the wing can improve aerodynamic performance. The influence of anisotropic effects of piezoelectric actuators on the aerodynamic characteristics of a simplified HALE wing model was investigated. Test verification was conducted.
Metastability Thresholds for Anisotropic Bootstrap Percolation in Three Dimensions
Van Enter, A.C.D.; Fey, A.
2012-01-01
In this paper we analyze several anisotropic bootstrap percolation models in three dimensions. We present the order of magnitude for the metastability thresholds for a fairly general class of models. In our proofs, we use an adaptation of the technique of dimensional reduction. We find that the orde
Metastability thresholds for anisotropic bootstrap percolation in three dimensions
Van Enter, A.C.D.; Fey, A.
2012-01-01
In this paper we analyze several anisotropic bootstrap percolation models in three dimensions. We present the order of magnitude for the metastability thresholds for a fairly general class of models. In our proofs, we use an adaptation of the technique of dimensional reduction. We find that the orde
Self-collimation in photonic crystals with anisotropic constituents
Institute of Scientific and Technical Information of China (English)
J. W. Haus; M. Siraj; P. Prasad; P. Markowicz
2007-01-01
@@ In a photonic crystal composed of anisotropic constituents we quantify the range of input angles and the degree of collimation of the beam inside the crystal. The optical properties of a photobleached 4-dimethylamino-N-methyl-4-stilbazolium-tosylate (DAST) crystal are used in our model to demonstrate the efficacy of the self-collimation features.
On the interpretation of time-resolved anisotropic diffraction patterns
DEFF Research Database (Denmark)
Lorenz, Ulf; Møller, Klaus Braagaard; Henriksen, Niels Engholm
2010-01-01
In this paper, we review existing systematic treatments for the interpretation of anisotropic diffraction patterns from partially aligned symmetric top molecules. Such patterns arise in the context of time-resolved diffraction experiments. We calculate diffraction patterns for ground-state Na...
Inversions for MT data in 2D symmetrical anisotropic media
Institute of Scientific and Technical Information of China (English)
YANG Chang-fu; LIN Chang-you; SUN Chong-chi; LI Qing-he
2005-01-01
In the paper, a 2D symmetrical anisotropic medium whose strike agrees with one of the horizontal principal axes is considered to develop a corresponding inversion technique. In the specified conditions, if we assume an equivalent conductivity anisotropy in both the vertical and dipping directions, i.e., σzz=σyy, the differential equations obtained are formally the same as that for TE and TM modes in the 2D isotropic geoelectrical media. The same inversion technique as that in the 2D isotropic media can be employed to obtain the anisotropic conductivities. It means that the TE and TM inversion results in the isotropic media can be respectively thought as the resistivities in the two principal directions of the symmetrically anisotropic media, which has offered a new approach and a theoretical guidance for interpreting magnetotelluric data. And the inversion technique developed here is used to test the magnetotelluric data in the area of Tianzhu and Yongdeng in Gansu Province, so that the crust anisotropic geoelectrical structures in this region can be obtained.
Comparing energy levels in isotropic and anisotropic potentials
Pikovski, Alexander
2015-01-01
Qualitative information about the quantized energy levels of a system can be of great value. We study the relationship between the bound-state energies of an anisotropic potential and those of its spherical average. It is shown that the two ground-state energies satisfy an inequality, and there is a similar inequality for the first excited states.
A new approach to electromagnetism in anisotropic spaces
Voicu-Brinzei, Nicoleta; Siparov, Sergey
2009-01-01
Anisotropy of a space naturally leads to direction dependent electromagnetic tensors and electromagnetic potentials. Starting from this idea and using variational approaches and exterior derivative formalism, we extend some of the classical equations of electromagnetism to anisotropic (Finslerian) spaces. The results differ from the ones obtained by means of the known approach in [3], [4].
Characterization of highly anisotropic three-dimensionally nanostructured surfaces
International Nuclear Information System (INIS)
Generalized ellipsometry, a non-destructive optical characterization technique, is employed to determine geometrical structure parameters and anisotropic dielectric properties of highly spatially coherent three-dimensionally nanostructured thin films grown by glancing angle deposition. The (piecewise) homogeneous biaxial layer model approach is discussed, which can be universally applied to model the optical response of sculptured thin films with different geometries and from diverse materials, and structural parameters as well as effective optical properties of the nanostructured thin films are obtained. Alternative model approaches for slanted columnar thin films, anisotropic effective medium approximations based on the Bruggeman formalism, are presented, which deliver results comparable to the homogeneous biaxial layer approach and in addition provide film constituent volume fraction parameters as well as depolarization or shape factors. Advantages of these ellipsometry models are discussed on the example of metal slanted columnar thin films, which have been conformally coated with a thin passivating oxide layer by atomic layer deposition. Furthermore, the application of an effective medium approximation approach to in-situ growth monitoring of this anisotropic thin film functionalization process is presented. It was found that structural parameters determined with the presented optical model equivalents for slanted columnar thin films agree very well with scanning electron microscope image estimates. - Highlights: • Summary of optical model strategies for sculptured thin films with arbitrary geometries • Application of the rigorous anisotropic Bruggeman effective medium applications • In-situ growth monitoring of atomic layer deposition on biaxial metal slanted columnar thin film
Generalized anisotropic strange star models for compact stars
Mauryaa, S K; Dayanandan, Baiju; Jasim, M K; Al-Jamel, Ahmed
2015-01-01
We present new anisotropic generalization of Buchdahl [1] type perfect fluid solution by using the method of earlier work [2]. In similar approach we have constructed the new pressure anisotropy factor {\\Delta} by the help both the metric potential e^{\\lambda} and e^{\
Quark–gluon plasma phenomenology from anisotropic lattice QCD
International Nuclear Information System (INIS)
The FASTSUM collaboration has been carrying out simulations of Nf = 2 + 1 QCD at nonzero temperature in the fixed-scale approach using anisotropic lattices. Here we present the status of these studies, including recent results for electrical conductivity and charge diffusion, and heavy quarkonium (charm and beauty) physics