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Sample records for animal behaviour neglecting

  1. Collective behaviour across animal species.

    Science.gov (United States)

    DeLellis, Pietro; Polverino, Giovanni; Ustuner, Gozde; Abaid, Nicole; Macrì, Simone; Bollt, Erik M; Porfiri, Maurizio

    2014-01-16

    We posit a new geometric perspective to define, detect, and classify inherent patterns of collective behaviour across a variety of animal species. We show that machine learning techniques, and specifically the isometric mapping algorithm, allow the identification and interpretation of different types of collective behaviour in five social animal species. These results offer a first glimpse at the transformative potential of machine learning for ethology, similar to its impact on robotics, where it enabled robots to recognize objects and navigate the environment.

  2. Functional Assessment of Region-Specific Neglect: Are There Differential Behavioural Consequences of Peripersonal versus Extrapersonal Neglect?

    Directory of Open Access Journals (Sweden)

    T. C. W. Nijboer

    2014-01-01

    Full Text Available Background. Region-specific types of neglect (peripersonal and extrapersonal have been dissociated, yet, differential behavioural consequences are unknown. Objective. The aim of the current study was to investigate behavioural consequences at the level of basic activities of daily living of region-specific neglect, using the Catherine Bergego Scale (CBS. Methods. 118 stroke patients were screened within the first two weeks after admission to the rehabilitation center for inpatient rehabilitation. Results. Patients with peripersonal neglect and patients with neglect for both regions had significantly higher total score on the CBS compared to nonneglect patients. Total scores for patients with extrapersonal neglect were comparable to non-neglect patients. ADL impairments were found across activities (e.g., looking towards one side, forgetting body parts, colliding for both patients with peripersonal neglect and patients with neglect for both regions. Patients with extrapersonal neglect were only impaired on the item on way finding. Conclusions. When diagnosing neglect, it is relevant to distinguish the type of region-specific neglect and, where needed, to adjust the rehabilitation program accordingly. As the CBS is not developed to typically measure ADL in extrapersonal neglect, it would be of importance to add other (instrumental activities that heavily rely on processing information in farther space.

  3. Functional assessment of region-specific neglect: are there differential behavioural consequences of peripersonal versus extrapersonal neglect?

    NARCIS (Netherlands)

    Nijboer, T.C.W.; Ten Brink, A.F.; Kouwenhoven, M.; Visser-Meily, J.M.A.

    2014-01-01

    Background. Region-specific types of neglect (peripersonal and extrapersonal) have been dissociated, yet, differential behavioural consequences are unknown. Objective. The aim of the current study was to investigate behavioural consequences at the level of basic activities of daily living of region-

  4. Comparison of the Behavioural Inattention Test and the Catherine Bergego Scale in assessment of hemispatial neglect.

    Science.gov (United States)

    Luukkainen-Markkula, R; Tarkka, I M; Pitkanen, K; Sivenius, J; Hamalainen, H

    2011-01-01

    The objective of the study was to correlate visual and behavioural assessments of hemispatial neglect caused by cerebrovascular accident. We assessed 17 consecutive right-hemisphere stroke patients with hemispatial neglect: the Catherine Bergego Scale (CBS) was used to evaluate neglect in spontaneous behaviour and the conventional subtests of the Behavioural Inattention Test (BIT C) were used to assess visual neglect. The proportional severity of both visual and behavioural neglect was calculated in each individual patient. Dissociations were found between mild neglect in visual screening tasks and moderate or severe neglect in behaviour, although in most patients, neglect was equally evident in both tests. Only the line bisection subtest from the BIT correlated significantly with the CBS, yet both tests showed good internal consistency. The line bisection test and several items of the CBS were especially sensitive in detecting the combination of visual field deficit and hemispatial neglect. In conclusion, we propose that visual fields should always be assessed in patients with neglect because neglect may be exacerbated by a visual field deficit and this can cause prolonged functional disability in everyday life situations. Specific rehabilitation methods might also be needed in neglect with or without hemianopia.

  5. Virtual ethology of aquatic animal heterogeneous behaviours

    Science.gov (United States)

    Lim, ChenKim; Tan, KianLam

    2016-08-01

    In the virtual world, the simulation of flocking behaviour has been actively investigated since the 1980 through the boid models. However, ethology is a niche study of animal behaviour from the biological perspective that is rarely instil in the interest of the younger learners nowadays. The keystone of the research is to be able to disseminate the study of animal behaviours through the boid model with the aid of technology. Through the simulation, complex movement of animal behaviours are reproduced based on the extension of basic behaviours of boid algorithm. The techniques here are to (i) Analyse a high-level behavioural framework of motion in the animal behaviours and (ii) Evolves particles to other animal representations to portray more real-time examples of steering behaviours. Although the generality of the results is limited by the number of case study, it also supports the hypothesis that interactive simulation system of virtual ethology can aid the improvement of animal studies.

  6. Agent-based simulation of animal behaviour

    OpenAIRE

    Jonker, C.M.; Treur, J.

    1998-01-01

    In this paper it is shown how animal behaviour can be simulated in an agent-based manner. Different models are shown for different types of behaviour, varying from purely reactive behaviour to pro-active, social and adaptive behaviour. The compositional development method for multi-agent systems DESIRE and its software environment supports the conceptual and detailed design, and execution of these models. Experiments reported in the literature on animal behaviour have been simulated for a num...

  7. Breeding for behavioural change in farm animals

    DEFF Research Database (Denmark)

    D'Eath, R.B.; Conington, J.; Lawrence, A.B.

    2010-01-01

    In farm animal breeding, behavioural traits are rarely included in selection programmes despite their potential to improve animal production and welfare. Breeding goals have been broadened beyond production traits in most farm animal species to include health and functional traits, and opportunit...

  8. Agent-based simulation of animal behaviour

    NARCIS (Netherlands)

    Jonker, C.M.; Treur, J.

    2001-01-01

    In the biological literature on animal behaviour, in addition to real experiments and field studies, also simulation experiments are a useful source of progress. Often specific mathematical modelling techniques are adopted and directly implemented in a programming language. Modelling more complex ag

  9. Best behaviour? Ontologies and the formal description of animal behaviour

    KAUST Repository

    Gkoutos, Georgios V.

    2015-07-28

    The development of ontologies for describing animal behaviour has proved to be one of the most difficult of all scientific knowledge domains. Ranging from neurological processes to human emotions, the range and scope needed for such ontologies is highly challenging, but if data integration and computational tools such as automated reasoning are to be fully applied in this important area the underlying principles of these ontologies need to be better established and development needs detailed coordination. Whilst the state of scientific knowledge is always paramount in ontology and formal description framework design, this is a particular problem with neurobehavioural ontologies where our understanding of the relationship between behaviour and its underlying biophysical basis is currently in its infancy. In this commentary, we discuss some of the fundamental problems in designing and using behaviour ontologies, and present some of the best developed tools in this domain. © 2015 Springer Science+Business Media New York

  10. Best behaviour? Ontologies and the formal description of animal behaviour.

    Science.gov (United States)

    Gkoutos, Georgios V; Hoehndorf, Robert; Tsaprouni, Loukia; Schofield, Paul N

    2015-10-01

    The development of ontologies for describing animal behaviour has proved to be one of the most difficult of all scientific knowledge domains. Ranging from neurological processes to human emotions, the range and scope needed for such ontologies is highly challenging, but if data integration and computational tools such as automated reasoning are to be fully applied in this important area the underlying principles of these ontologies need to be better established and development needs detailed coordination. Whilst the state of scientific knowledge is always paramount in ontology and formal description framework design, this is a particular problem with neurobehavioural ontologies where our understanding of the relationship between behaviour and its underlying biophysical basis is currently in its infancy. In this commentary, we discuss some of the fundamental problems in designing and using behaviour ontologies, and present some of the best developed tools in this domain.

  11. The modelling cycle for collective animal behaviour.

    Science.gov (United States)

    Sumpter, David J T; Mann, Richard P; Perna, Andrea

    2012-12-06

    Collective animal behaviour is the study of how interactions between individuals produce group level patterns, and why these interactions have evolved. This study has proved itself uniquely interdisciplinary, involving physicists, mathematicians, engineers as well as biologists. Almost all experimental work in this area is related directly or indirectly to mathematical models, with regular movement back and forth between models, experimental data and statistical fitting. In this paper, we describe how the modelling cycle works in the study of collective animal behaviour. We classify studies as addressing questions at different levels or linking different levels, i.e. as local, local to global, global to local or global. We also describe three distinct approaches-theory-driven, data-driven and model selection-to these questions. We show, with reference to our own research on species across different taxa, how we move between these different levels of description and how these various approaches can be applied to link levels together.

  12. Neglected fungal zoonoses : hidden threats to man and animals

    NARCIS (Netherlands)

    Seyedmousavi, S; Guillot, J; Tolooe, A; Verweij, P E; de Hoog, G S

    2015-01-01

    Zoonotic fungi can be naturally transmitted between animals and humans, and in some cases cause significant public health problems. A number of mycoses associated with zoonotic transmission are among the group of the most common fungal diseases, worldwide. It is, however, notable that some fungal di

  13. Neglected fungal zoonoses: hidden threats to man and animals

    NARCIS (Netherlands)

    Seyedmousavi, S.; Guillot, J.; Tolooe, A.; Verweij, P.E.; Hoog, G.S. de

    2015-01-01

    Zoonotic fungi can be naturally transmitted between animals and humans, and in some cases cause significant public health problems. A number of mycoses associated with zoonotic transmission are among the group of the most common fungal diseases, worldwide. It is, however, notable that some fungal di

  14. Neglected fungal zoonoses: Hidden threats to man and animals

    NARCIS (Netherlands)

    S. Seyedmousavi (Seyedmojtaba); J. Guillot; A. Tolooe (Ali); P.E. Verweij (Paul); G.S. de Hoog

    2015-01-01

    textabstractZoonotic fungi can be naturally transmitted between animals and humans, and in some cases cause significant public health problems. A number of mycoses associated with zoonotic transmission are among the group of the most common fungal diseases, worldwide. It is, however, notable that so

  15. Neglected fungal zoonoses: hidden threats to man and animals.

    Science.gov (United States)

    Seyedmousavi, S; Guillot, J; Tolooe, A; Verweij, P E; de Hoog, G S

    2015-05-01

    Zoonotic fungi can be naturally transmitted between animals and humans, and in some cases cause significant public health problems. A number of mycoses associated with zoonotic transmission are among the group of the most common fungal diseases, worldwide. It is, however, notable that some fungal diseases with zoonotic potential have lacked adequate attention in international public health efforts, leading to insufficient attention on their preventive strategies. This review aims to highlight some mycoses whose zoonotic potential received less attention, including infections caused by Talaromyces (Penicillium) marneffei, Lacazia loboi, Emmonsia spp., Basidiobolus ranarum, Conidiobolus spp. and Paracoccidioides brasiliensis.

  16. Transgenerational epigenetic effects on animal behaviour.

    Science.gov (United States)

    Jensen, Per

    2013-12-01

    Over the last decade a shift in paradigm has occurred with respect to the interaction between environment and genes. It is now clear that animal genomes are regulated to a large extent as a result of input from environmental events and experiences, which cause short- and long-term modifications in epigenetic markings of DNA and histones. In this review, the evidence that such epigenetic modifications can affect the behaviour of animals is explored, and whether such acquired behaviour alterations can transfer across generation borders. First, the mechanisms by which experiences cause epigenetic modifications are examined. This includes, for example, methylation of cytosine in CpG positions and acetylation of histones, and studies showing that this can be modified by early experiences. Secondly, the evidence that specific modifications in the epigenome can be the cause of behaviour variation is reviewed. Thirdly, the extent to which this phenotypically active epigenetic variants can be inherited either through the germline or through reoccurring environmental conditions is examined. A particularly interesting observation is that epigenetic modifications are often linked to stress, and may possibly be mediated by steroid effects. Finally, the idea that transgenerationally stable epigenetic variants may serve as substrates for natural selection is explored, and it is speculated that they may even predispose for directed, non-random mutations.

  17. Association between Physical Abuse, Physical Neglect and Health Risk Behaviours among Young Adolescents: Results from the National Study

    Directory of Open Access Journals (Sweden)

    Dimitrinka Jordanova Peshevska

    2014-06-01

    CONCLUSION: The results demonstrated a relationship between physical abuse and later manifestation of health risk behaviours such as: smoking and early pregnancy. Physical neglect increased the chances for drug abuse, drink-driving, having early sex, having more sexual partners.

  18. Teachers' reporting of suspected child abuse and neglect: behaviour and determinants.

    Science.gov (United States)

    Goebbels, A F G; Nicholson, J M; Walsh, K; De Vries, H

    2008-12-01

    By reporting suspected child abuse and neglect, teachers can make an important contribution to the early detection and prevention of abuse. However, teachers are sometimes reluctant to report their suspicions. This study investigated the determinants of teachers' reporting behaviour using concepts from the Integrated Change Model. Self-report data were collected from 296 teachers employed in 15 Australian schools. Compared to their colleagues, teachers who had never suspected child abuse or neglect (non-detectors, N=57, 19%) were more likely to have a lower confidence in their skills for recognising the signs of abuse, a higher degree of perceived social support regarding reporting, less years teaching experience and lower academic qualifications. Among those who had suspected cases of child abuse or neglect (N=239, 81%), teachers who always reported their suspicions (consistent reporters, 82%) were more likely to have firm action plans about reporting and detecting signs of CAN than teachers who did not always report their suspicions (inconsistent reporters, 18%). While only a small proportion of the variance in detection and reporting status was explained, the results illustrate the utility of health promotion theory and methods for improving our understanding of these behaviours.

  19. Behavioural reaction norms : animal personality meets individual plasticity

    NARCIS (Netherlands)

    Dingemanse, Niels J.; Kazem, Anahita J. N.; Reale, Denis; Wright, Jonathan

    2010-01-01

    Recent studies in the field of behavioural ecology have revealed intriguing variation in behaviour within single populations. Increasing evidence suggests that individual animals differ in their average level of behaviour displayed across a range of contexts (animal 'personality'), and in their resp

  20. Conceptualising Animal Abuse with an Antisocial Behaviour Framework.

    Science.gov (United States)

    Gullone, Eleonora

    2011-01-26

    This paper reviews current findings in the human aggression and antisocial behaviour literature and those in the animal abuse literature with the aim of highlighting the overlap in conceptualisation. The major aim of this review is to highlight that the co-occurrence between animal abuse behaviours and aggression and violence toward humans can be logically understood through examination of the research evidence for antisocial and aggressive behaviour. From examination through this framework, it is not at all surprising that the two co-occur. Indeed, it would be surprising if they did not. Animal abuse is one expression of antisocial behaviour. What is also known from the extensive antisocial behaviour literature is that antisocial behaviours co-occur such that the presence of one form of antisocial behaviour is highly predictive of the presence of other antisocial behaviours. From such a framework, it becomes evident that animal abuse should be considered an important indicator of antisocial behaviour and violence as are other aggressive and antisocial behaviours. The implications of such a stance are that law enforcement, health and other professionals should not minimize the presence of animal abuse in their law enforcement, prevention, and treatment decisions.

  1. Animal personality as a cause and consequence of contest behaviour.

    Science.gov (United States)

    Briffa, Mark; Sneddon, Lynne U; Wilson, Alastair J

    2015-03-01

    We review the evidence for a link between consistent among-individual variation in behaviour (animal personality) and the ability to win contests over limited resources. Explorative and bold behaviours often covary with contest behaviour and outcome, although there is evidence that the structure of these 'behavioural syndromes' can change across situations. Aggression itself is typically repeatable, but also subject to high within-individual variation as a consequence of plastic responses to previous fight outcomes and opponent traits. Common proximate mechanisms (gene expression, endocrine control and metabolic rates) may underpin variation in both contest behaviour and general personality traits. Given the theoretical links between the evolution of fighting and of personality, we suggest that longitudinal studies of contest behaviour, combining behavioural and physiological data, would be a useful context for the study of animal personalities.

  2. Host behaviour-parasite feedback: an essential link between animal behaviour and disease ecology.

    Science.gov (United States)

    Ezenwa, Vanessa O; Archie, Elizabeth A; Craft, Meggan E; Hawley, Dana M; Martin, Lynn B; Moore, Janice; White, Lauren

    2016-04-13

    Animal behaviour and the ecology and evolution of parasites are inextricably linked. For this reason, animal behaviourists and disease ecologists have been interested in the intersection of their respective fields for decades. Despite this interest, most research at the behaviour-disease interface focuses either on how host behaviour affects parasites or how parasites affect behaviour, with little overlap between the two. Yet, the majority of interactions between hosts and parasites are probably reciprocal, such that host behaviour feeds back on parasites and vice versa. Explicitly considering these feedbacks is essential for understanding the complex connections between animal behaviour and parasite ecology and evolution. To illustrate this point, we discuss how host behaviour-parasite feedbacks might operate and explore the consequences of feedback for studies of animal behaviour and parasites. For example, ignoring the feedback of host social structure on parasite dynamics can limit the accuracy of predictions about parasite spread. Likewise, considering feedback in studies of parasites and animal personalities may provide unique insight about the maintenance of variation in personality types. Finally, applying the feedback concept to links between host behaviour and beneficial, rather than pathogenic, microbes may shed new light on transitions between mutualism and parasitism. More generally, accounting for host behaviour-parasite feedbacks can help identify critical gaps in our understanding of how key host behaviours and parasite traits evolve and are maintained.

  3. Remote Laboratory and Animal Behaviour: An Interactive Open Field System

    Science.gov (United States)

    Fiore, Lorenzo; Ratti, Giovannino

    2007-01-01

    Remote laboratories can provide distant learners with practical acquisitions which would otherwise remain precluded. Our proposal here is a remote laboratory on a behavioural test (open field test), with the aim of introducing learners to the observation and analysis of stereotyped behaviour in animals. A real-time video of a mouse in an…

  4. From Sensor Data to Animal Behaviour: An Oystercatcher Example

    OpenAIRE

    2012-01-01

    Animal-borne sensors enable researchers to remotely track animals, their physiological state and body movements. Accelerometers, for example, have been used in several studies to measure body movement, posture, and energy expenditure, although predominantly in marine animals. In many studies, behaviour is often inferred from expert interpretation of sensor data and not validated with direct observations of the animal. The aim of this study was to derive models that could be used to classify o...

  5. Keeper-Animal Interactions: Differences between the Behaviour of Zoo Animals Affect Stockmanship.

    Directory of Open Access Journals (Sweden)

    Samantha J Ward

    Full Text Available Stockmanship is a term used to describe the management of animals with a good stockperson someone who does this in a in a safe, effective, and low-stress manner for both the stock-keeper and animals involved. Although impacts of unfamiliar zoo visitors on animal behaviour have been extensively studied, the impact of stockmanship i.e familiar zoo keepers is a new area of research; which could reveal significant ramifications for zoo animal behaviour and welfare. It is likely that different relationships are formed dependant on the unique keeper-animal dyad (human-animal interaction, HAI. The aims of this study were to (1 investigate if unique keeper-animal dyads were formed in zoos, (2 determine whether keepers differed in their interactions towards animals regarding their attitude, animal knowledge and experience and (3 explore what factors affect keeper-animal dyads and ultimately influence animal behaviour and welfare. Eight black rhinoceros (Diceros bicornis, eleven Chapman's zebra (Equus burchellii, and twelve Sulawesi crested black macaques (Macaca nigra were studied in 6 zoos across the UK and USA. Subtle cues and commands directed by keepers towards animals were identified. The animals latency to respond and the respective behavioural response (cue-response was recorded per keeper-animal dyad (n = 93. A questionnaire was constructed following a five-point Likert Scale design to record keeper demographic information and assess the job satisfaction of keepers, their attitude towards the animals and their perceived relationship with them. There was a significant difference in the animals' latency to appropriately respond after cues and commands from different keepers, indicating unique keeper-animal dyads were formed. Stockmanship style was also different between keepers; two main components contributed equally towards this: "attitude towards the animals" and "knowledge and experience of the animals". In this novel study, data demonstrated

  6. Keeper-Animal Interactions: Differences between the Behaviour of Zoo Animals Affect Stockmanship.

    Science.gov (United States)

    Ward, Samantha J; Melfi, Vicky

    2015-01-01

    Stockmanship is a term used to describe the management of animals with a good stockperson someone who does this in a in a safe, effective, and low-stress manner for both the stock-keeper and animals involved. Although impacts of unfamiliar zoo visitors on animal behaviour have been extensively studied, the impact of stockmanship i.e familiar zoo keepers is a new area of research; which could reveal significant ramifications for zoo animal behaviour and welfare. It is likely that different relationships are formed dependant on the unique keeper-animal dyad (human-animal interaction, HAI). The aims of this study were to (1) investigate if unique keeper-animal dyads were formed in zoos, (2) determine whether keepers differed in their interactions towards animals regarding their attitude, animal knowledge and experience and (3) explore what factors affect keeper-animal dyads and ultimately influence animal behaviour and welfare. Eight black rhinoceros (Diceros bicornis), eleven Chapman's zebra (Equus burchellii), and twelve Sulawesi crested black macaques (Macaca nigra) were studied in 6 zoos across the UK and USA. Subtle cues and commands directed by keepers towards animals were identified. The animals latency to respond and the respective behavioural response (cue-response) was recorded per keeper-animal dyad (n = 93). A questionnaire was constructed following a five-point Likert Scale design to record keeper demographic information and assess the job satisfaction of keepers, their attitude towards the animals and their perceived relationship with them. There was a significant difference in the animals' latency to appropriately respond after cues and commands from different keepers, indicating unique keeper-animal dyads were formed. Stockmanship style was also different between keepers; two main components contributed equally towards this: "attitude towards the animals" and "knowledge and experience of the animals". In this novel study, data demonstrated unique dyads

  7. Veterinarians' perceptions of behaviour support in small-animal practice.

    Science.gov (United States)

    Roshier, A L; McBride, E A

    2013-03-09

    Veterinarians are professionals considered to be at the forefront of animal welfare, including behaviour medicine. However, concerns raised, both within the profession and without, highlight that the support offered is not optimal, due to deficiencies in veterinary training, which focuses on physical aspects and overlooks psychological aspects. This preliminary study explored the experiences and perceptions of six veterinarians (three male, three female, age range: 23-55 years) in two UK small-animal practices. Seventeen annual booster consultations were videoed and conversations thematically analysed for welfare topics discussed. Both veterinarians and clients completed questionnaires to gather demographic information and perspectives. All veterinarians recognised behaviour as a component of their caseload, and acknowledged that clients expected them to provide behaviour support. Veterinarians varied in their experiences of and confidence in providing behaviour support. Five felt unable to meet client expectations; four did not feel their training had prepared them sufficiently. Only one provided dedicated behaviour consultations, the others referred cases. All provided suggestions for behaviour skills needed for new veterinary graduates. The study has afforded an insight into the experiences of a small opportunistic sample of veterinarians. The data indicated important limitations regarding time available in general consultations to discuss behaviour concerns, and practitioner knowledge and skill in detection, anamnesis, assessment and provision of appropriate behaviour information. Suggestions for veterinary training in behaviour are provided.

  8. The Spatial Behaviour of Animals and Men

    Science.gov (United States)

    Brindley, T. S.

    1973-01-01

    Describes some common patterns of animal spatial behavior, and discusses spatial relationships that can be observed as an important component of human social behavior. Reports the results of a study relating to the interpersonal distances of people in bus queues in Britain. (JR)

  9. From sensor data to animal behaviour: an oystercatcher example.

    Directory of Open Access Journals (Sweden)

    Judy Shamoun-Baranes

    Full Text Available Animal-borne sensors enable researchers to remotely track animals, their physiological state and body movements. Accelerometers, for example, have been used in several studies to measure body movement, posture, and energy expenditure, although predominantly in marine animals. In many studies, behaviour is often inferred from expert interpretation of sensor data and not validated with direct observations of the animal. The aim of this study was to derive models that could be used to classify oystercatcher (Haematopus ostralegus behaviour based on sensor data. We measured the location, speed, and tri-axial acceleration of three oystercatchers using a flexible GPS tracking system and conducted simultaneous visual observations of the behaviour of these birds in their natural environment. We then used these data to develop three supervised classification trees of behaviour and finally applied one of the models to calculate time-activity budgets. The model based on accelerometer data developed to classify three behaviours (fly, terrestrial locomotion, and no movement was much more accurate (cross-validation error = 0.14 than the model based on GPS-speed alone (cross-validation error = 0.35. The most parsimonious acceleration model designed to classify eight behaviours could distinguish five: fly, forage, body care, stand, and sit (cross-validation error = 0.28; other behaviours that were observed, such as aggression or handling of prey, could not be distinguished. Model limitations and potential improvements are discussed. The workflow design presented in this study can facilitate model development, be adapted to a wide range of species, and together with the appropriate measurements, can foster the study of behaviour and habitat use of free living animals throughout their annual routine.

  10. From sensor data to animal behaviour: an oystercatcher example.

    Science.gov (United States)

    Shamoun-Baranes, Judy; Bom, Roeland; van Loon, E Emiel; Ens, Bruno J; Oosterbeek, Kees; Bouten, Willem

    2012-01-01

    Animal-borne sensors enable researchers to remotely track animals, their physiological state and body movements. Accelerometers, for example, have been used in several studies to measure body movement, posture, and energy expenditure, although predominantly in marine animals. In many studies, behaviour is often inferred from expert interpretation of sensor data and not validated with direct observations of the animal. The aim of this study was to derive models that could be used to classify oystercatcher (Haematopus ostralegus) behaviour based on sensor data. We measured the location, speed, and tri-axial acceleration of three oystercatchers using a flexible GPS tracking system and conducted simultaneous visual observations of the behaviour of these birds in their natural environment. We then used these data to develop three supervised classification trees of behaviour and finally applied one of the models to calculate time-activity budgets. The model based on accelerometer data developed to classify three behaviours (fly, terrestrial locomotion, and no movement) was much more accurate (cross-validation error = 0.14) than the model based on GPS-speed alone (cross-validation error = 0.35). The most parsimonious acceleration model designed to classify eight behaviours could distinguish five: fly, forage, body care, stand, and sit (cross-validation error = 0.28); other behaviours that were observed, such as aggression or handling of prey, could not be distinguished. Model limitations and potential improvements are discussed. The workflow design presented in this study can facilitate model development, be adapted to a wide range of species, and together with the appropriate measurements, can foster the study of behaviour and habitat use of free living animals throughout their annual routine.

  11. Neglect-like visual exploration behaviour after theta burst transcranial magnetic stimulation of the right posterior parietal cortex.

    Science.gov (United States)

    Nyffeler, Thomas; Cazzoli, Dario; Wurtz, Pascal; Lüthi, Mathias; von Wartburg, Roman; Chaves, Silvia; Déruaz, Anouk; Hess, Christian W; Müri, René M

    2008-04-01

    The right posterior parietal cortex (PPC) is critically involved in visual exploration behaviour, and damage to this area may lead to neglect of the left hemispace. We investigated whether neglect-like visual exploration behaviour could be induced in healthy subjects using theta burst repetitive transcranial magnetic stimulation (rTMS). To this end, one continuous train of theta burst rTMS was applied over the right PPC in 12 healthy subjects prior to a visual exploration task where colour photographs of real-life scenes were presented on a computer screen. In a control experiment, stimulation was also applied over the vertex. Eye movements were measured, and the distribution of visual fixations in the left and right halves of the screen was analysed. In comparison to the performance of 28 control subjects without stimulation, theta burst rTMS over the right PPC, but not the vertex, significantly decreased cumulative fixation duration in the left screen-half and significantly increased cumulative fixation duration in the right screen-half for a time period of 30 min. These results suggest that theta burst rTMS is a reliable method of inducing transient neglect-like visual exploration behaviour.

  12. Social behaviour and collective motion in plant-animal worms

    OpenAIRE

    Franks, N. R.; Worley, A.; Grant, K. A. G.; A. R. Gorman; Vizard, V.; Plackett, H.; Doran, C.; Gamble, M. L.; Stumpe, M.; Sendova-Franks, A. B.

    2016-01-01

    Social behaviour may enable organisms to occupy ecological niches that would otherwise be unavailable to them. Here we test this major evolutionary principle by demonstrating self-organizing social behaviour in the plant-animal, Symsagittifera roscoffensis. These marine aceol flat worms rely for all of their nutrition on the algae within their bodies: hence their common name. We show that individual worms interact with one another to co-ordinate their movements so that even at low densities t...

  13. [Cognitive enrichment in zoo and farm animals--implications for animal behaviour and welfare].

    Science.gov (United States)

    Meyer, Susann; Puppe, Birger; Langbein, Jan

    2010-01-01

    Animals in the wild are facing a wide variety of challenges and ever-changing environmental stimuli. For successful coping, animals use both innate behavioural programs and their cognitive skills. In contrast, zoo- and farm animals have to cope with restricted husbandry conditions, which offer only few opportunities to adequately satisfy their various needs. Consequences could be sensory and cognitive underchallenge that can cause boredom and frustration as well as behavioural disturbances. Initially intended for improvement of management and husbandry, different forms of operant behavioural training have been applied firstly in zoo- and later also in farm animals. It has been suggested that successful coping with appropriate cognitive challenges is a source of positive emotions and may lead to improved welfare. Under the term cognitive enrichment, new approaches have been developed to integrate cognitive challenges into the housing of zoo- and farm animals. The present article reviews actual research in the field. Previous results indicate that, beyond improvement of management and handling routines, such approaches can positively affect animal behaviour and welfare. The combination of explorative and appetitive behaviour with successful learning improves environmental predictability and controllability for the animals, activates reward-related brain systems and can directly affect emotional processes of appraisal. For practical implementation in farm animal husbandry, it sounds promising to link individual access to e.g. automated feeders or milking systems with previously conditioned stimuli and/or discriminatory learning tasks. First experimental approaches in pigs, dwarf goats and cattle are available and will be discussed in the present article.

  14. Review: Quantifying animal feeding behaviour with a focus on pigs.

    Science.gov (United States)

    Maselyne, Jarissa; Saeys, Wouter; Van Nuffel, Annelies

    2015-01-01

    The study of animal feeding behaviour is of interest to understand feeding, to investigate the effect of treatments and conditions or to predict illness. This paper reviews the different steps to undertake when studying animal feeding behaviour, with illustrations for group-housed pigs. First, one must be aware of the mechanisms that control feeding and the various influences that can change feeding behaviour. Satiety is shown to largely influence free feeding (ad libitum and without an operant condition) in animals, but 'free' feeding seems a very fragile process, given the many factors that can influence feeding behaviour. Second, a measurement method must be chosen that is compatible with the goal of the research. Several measurement methods exist, which lead to different experimental set-ups and measurement data. Sensors are available for lab conditions, for research on group-housed pigs and also for on-farm use. Most of these methods result in a record of feeding visits. However, these feeding visits are often found to be clustered into meals. Thus, the third step is to choose which unit of feeding behaviour to use for analysis. Depending on the situation, either meals, feeding visits, other raw data, or a combination thereof can be suitable. Meals are more appropriate for analysing short-term feeding behaviour, but this may not be true for disease detection. Further research is therefore needed. To cluster visits into meals, an appropriate analysis method has to be selected. The last part of this paper provides a review and discussion of the existing methods for meal determination. A variety of methods exist, with the most recent methods based on the influence of satiety on feeding. More thorough validation of the recent methods, including validation from a behavioural point of view and uniformity in the applied methods is therefore necessary.

  15. Animal emotions, behaviour and the promotion of positive welfare states.

    Science.gov (United States)

    Mellor, D J

    2012-01-01

    This paper presents a rationale that may significantly boost the drive to promote positive welfare states in animals. The rationale is based largely, but not exclusively, on an experimentally supported neuropsychological understanding of relationships between emotions and behaviour, an understanding that has not yet been incorporated into animal welfare science thinking. Reference is made to major elements of the neural/cognitive foundations of motivational drives that energise and direct particular behaviours and their related subjective or emotional experiences. These experiences are generated in part by sensory inputs that reflect the animal's internal functional state and by neural processing linked to the animal's perception of its external circumstances. The integrated subjective or emotional outcome of these inputs corresponds to the animal's welfare status. The internally generated subjective experiences represent motivational urges or drives that are predominantly negative and include breathlessness, thirst, hunger and pain. They are generated by, and elicit specific behaviours designed to correct, imbalances in the animal's internal functional state. Externally generated subjective experiences are said to be integral to the operation of interacting 'action-orientated systems' that give rise to particular behaviours and their negative or positive emotional contents. These action-orientated systems, described in neuropsychological terms, give rise to negative emotions that include fear, anger and panic, and positive emotions that include comfort, vitality, euphoria and playfulness. It is argued that early thinking about animal welfare management focused mainly on minimising disturbances to the internal functional states that generate associated unpleasant motivational urges or drives. This strategy produced animal welfare benefits, but at best it could only lift a poor net welfare status to a neutral one. In contrast, strategies designed to manipulate the

  16. Teamwork, pleasure and bargaining in animal social behaviour.

    Science.gov (United States)

    Roughgarden, J

    2012-07-01

    Intimate behaviour between animals is hypothesized to enable teamwork. The pleasure experienced in grooming, preening, dancing, mating and singing in synchrony is hypothesized to motivate participants to coordinate actions directed towards a shared goal that enhances each individual's fitness. This cooperative behaviour evolves as a mutual direct benefit, not as altruism. Teamwork leads to an equilibrium set of returns to the participants that may be modelled as a Nash bargaining solution instead of as the more familiar Nash equilibrium. The dynamics leading to that equilibrium may be modelled based on joint action instead of the more familiar individualistic action. Confusions by Binmore (J. Evol. Biol. 2010; 23: 1351) about this hypothesis are corrected.

  17. Behaviour of Dairy Cows, Useful Indicator in Assessing Animal Welfare

    Directory of Open Access Journals (Sweden)

    Ioana Cristina Andronie

    2012-10-01

    Full Text Available The purpose of this research was to establish the manner in which the flooring type may influence the welfare levelsin dairy cows by assessment of laminitis incidence and animals’ behaviour. 42 dairy cows were grouped based on theshelter floor surface: concrete with straw bedding, asphalted concrete with straw bedding and concrete plus shavings.The behaviour was assessed through direct observation and laminitis incidence was established by numericalassessment of locomotion prior or following milking.The results have indicated an increase of laminitis incidence by 15-25 % in B and C lot and was absent in A lot. Thelarge number of diseases was recorded on concrete floors with shavings bedding (53%. The behavioural displays ofthe cows suffering from laminitis were different from the healthy ones, as their resting behaviour outside the stallswas more prevalent (17.6% compared to 8.8% while the feeding behaviour was less present (10.1% compared to14.7%. Likewise, the socializing behaviour was more active in these animals, compared to the healthycows.

  18. Treating animal behaviour problems with sex hormones: an animal welfare issue

    OpenAIRE

    Jones, R.E.; McBride, E.A.

    2001-01-01

    In England and Germany, the methods used to modify unwanted animal behaviour in veterinary practices were investigated by questionnaire. The samples were created by a systematic section. Of the 216 questionnaires posted in each country, 66 replies from Germany (30.5%) and 76 from the UK (35.2%) were obtained and evaluated. The majority of veterinarians in both countries considered hormones effective in treating behaviour problems, but English veterinarians do so significantly more for cats an...

  19. Social behaviour and collective motion in plant-animal worms.

    Science.gov (United States)

    Franks, Nigel R; Worley, Alan; Grant, Katherine A J; Gorman, Alice R; Vizard, Victoria; Plackett, Harriet; Doran, Carolina; Gamble, Margaret L; Stumpe, Martin C; Sendova-Franks, Ana B

    2016-02-24

    Social behaviour may enable organisms to occupy ecological niches that would otherwise be unavailable to them. Here, we test this major evolutionary principle by demonstrating self-organizing social behaviour in the plant-animal, Symsagittifera roscoffensis. These marine aceol flat worms rely for all of their nutrition on the algae within their bodies: hence their common name. We show that individual worms interact with one another to coordinate their movements so that even at low densities they begin to swim in small polarized groups and at increasing densities such flotillas turn into circular mills. We use computer simulations to: (i) determine if real worms interact socially by comparing them with virtual worms that do not interact and (ii) show that the social phase transitions of the real worms can occur based only on local interactions between and among them. We hypothesize that such social behaviour helps the worms to form the dense biofilms or mats observed on certain sun-exposed sandy beaches in the upper intertidal of the East Atlantic and to become in effect a super-organismic seaweed in a habitat where macro-algal seaweeds cannot anchor themselves. Symsagittifera roscoffensis, a model organism in many other areas in biology (including stem cell regeneration), also seems to be an ideal model for understanding how individual behaviours can lead, through collective movement, to social assemblages.

  20. Landscape Utilisation, Animal Behaviour and Hendra Virus Risk.

    Science.gov (United States)

    Field, H E; Smith, C S; de Jong, C E; Melville, D; Broos, A; Kung, N; Thompson, J; Dechmann, D K N

    2016-03-01

    Hendra virus causes sporadic fatal disease in horses and humans in eastern Australia. Pteropid bats (flying-foxes) are the natural host of the virus. The mode of flying-fox to horse transmission remains unclear, but oro-nasal contact with flying-fox urine, faeces or saliva is the most plausible. We used GPS data logger technology to explore the landscape utilisation of black flying-foxes and horses to gain new insight into equine exposure risk. Flying-fox foraging was repetitious, with individuals returning night after night to the same location. There was a preference for fragmented arboreal landscape and non-native plant species, resulting in increased flying-fox activity around rural infrastructure. Our preliminary equine data logger study identified significant variation between diurnal and nocturnal grazing behaviour that, combined with the observed flying-fox foraging behaviour, could contribute to Hendra virus exposure risk. While we found no significant risk-exposing difference in individual horse movement behaviour in this study, the prospect warrants further investigation, as does the broader role of animal behaviour and landscape utilisation on the transmission dynamics of Hendra virus.

  1. The neglected neglect: auditory neglect.

    Science.gov (United States)

    Gokhale, Sankalp; Lahoti, Sourabh; Caplan, Louis R

    2013-08-01

    Whereas visual and somatosensory forms of neglect are commonly recognized by clinicians, auditory neglect is often not assessed and therefore neglected. The auditory cortical processing system can be functionally classified into 2 distinct pathways. These 2 distinct functional pathways deal with recognition of sound ("what" pathway) and the directional attributes of the sound ("where" pathway). Lesions of higher auditory pathways produce distinct clinical features. Clinical bedside evaluation of auditory neglect is often difficult because of coexisting neurological deficits and the binaural nature of auditory inputs. In addition, auditory neglect and auditory extinction may show varying degrees of overlap, which makes the assessment even harder. Shielding one ear from the other as well as separating the ear from space is therefore critical for accurate assessment of auditory neglect. This can be achieved by use of specialized auditory tests (dichotic tasks and sound localization tests) for accurate interpretation of deficits. Herein, we have reviewed auditory neglect with an emphasis on the functional anatomy, clinical evaluation, and basic principles of specialized auditory tests.

  2. Frigatebird behaviour at the ocean-atmosphere interface: integrating animal behaviour with multi-satellite data.

    Science.gov (United States)

    De Monte, Silvia; Cotté, Cedric; d'Ovidio, Francesco; Lévy, Marina; Le Corre, Matthieu; Weimerskirch, Henri

    2012-12-07

    Marine top predators such as seabirds are useful indicators of the integrated response of the marine ecosystem to environmental variability at different scales. Large-scale physical gradients constrain seabird habitat. Birds however respond behaviourally to physical heterogeneity at much smaller scales. Here, we use, for the first time, three-dimensional GPS tracking of a seabird, the great frigatebird (Fregata minor), in the Mozambique Channel. These data, which provide at the same time high-resolution vertical and horizontal positions, allow us to relate the behaviour of frigatebirds to the physical environment at the (sub-)mesoscale (10-100 km, days-weeks). Behavioural patterns are classified based on the birds' vertical displacement (e.g. fast/slow ascents and descents), and are overlaid on maps of physical properties of the ocean-atmosphere interface, obtained by a nonlinear analysis of multi-satellite data. We find that frigatebirds modify their behaviours concurrently to transport and thermal fronts. Our results suggest that the birds' co-occurrence with these structures is a consequence of their search not only for food (preferentially searched over thermal fronts) but also for upward vertical wind. This is also supported by their relationship with mesoscale patterns of wind divergence. Our multi-disciplinary method can be applied to forthcoming high-resolution animal tracking data, and aims to provide a mechanistic understanding of animals' habitat choice and of marine ecosystem responses to environmental change.

  3. The use of animal models in behavioural neuroscience research.

    Science.gov (United States)

    Bovenkerk, Bernice; Kaldewaij, Frederike

    2015-01-01

    Animal models are used in experiments in the behavioural neurosciences that aim to contribute to the prevention and treatment of cognitive and affective disorders in human beings, such as anxiety and depression. Ironically, those animals that are likely to be the best models for psychopathology are also likely to be considered the ones that are most morally problematic to use, if it seems probable that (and if indeed they are initially selected as models because) they have experiences that are similar to human experiences that we have strong reasons to avoid causing, and indeed aim to alleviate (such as pain, anxiety or sadness). In this paper, against the background of contemporary discussions in animal ethics and the philosophy of animal minds, we discuss the views that it is morally permissible to use animals in these kinds of experiments, and that it is better to use less cognitively complex animals (such as zebrafish) than more complex animals (such as dogs). First, we criticise some justifications for the claim that human beings and more complex animals have higher moral status. We argue that contemporary approaches that attribute equal moral status to all beings that are capable of conscious strivings strivings (e.g. avoiding pain and anxiety; aiming to eat and play) are based on more plausible assumptions. Second, we argue that it is problematic to assume that less cognitively complex animals have a lesser sensory and emotional experience than more complex beings across the board. In specific cases, there might be good reasons to assume that more complex beings would be harmed more by a specific physical or environmental intervention, but it might also be that they sometimes are harmed less because of a better ability to cope. Determining whether a specific experiment is justified is therefore a complex issue. Our aim in this chapter is to stimulate further reflection on these common assumptions behind the use of animal models for psychopathologies. In

  4. Bringing a Time-Depth Perspective to Collective Animal Behaviour.

    Science.gov (United States)

    Biro, Dora; Sasaki, Takao; Portugal, Steven J

    2016-07-01

    The field of collective animal behaviour examines how relatively simple, local interactions between individuals in groups combine to produce global-level outcomes. Existing mathematical models and empirical work have identified candidate mechanisms for numerous collective phenomena but have typically focused on one-off or short-term performance. We argue that feedback between collective performance and learning - giving the former the capacity to become an adaptive, and potentially cumulative, process - is a currently poorly explored but crucial mechanism in understanding collective systems. We synthesise material ranging from swarm intelligence in social insects through collective movements in vertebrates to collective decision making in animal and human groups, to propose avenues for future research to identify the potential for changes in these systems to accumulate over time.

  5. Recognizing and responding to cases of suspected animal cruelty, abuse, and neglect: what the veterinarian needs to know

    Directory of Open Access Journals (Sweden)

    Arkow P

    2015-11-01

    Full Text Available Phil Arkow National Link Coalition – The National Resource Center on The Link Between Animal Abuse and Human Violence, Stratford, NJ, USA Abstract: The identification of a “battered pets” syndrome, which put the veterinary profession on a parallel footing with its counterparts in human medicine who respond to battered children, women, and elders, expanded the veterinarian’s role as an advocate for animals’ welfare to include the recognition of, response to, and prevention of animal abuse. Professional policies and legislation in several nations have been amended to define these responsibilities and delineate appropriate responses when animal maltreatment or other forms of family violence are suspected. This article reviews these changes, discusses abuse as a matter of animal welfare and public health, and summarizes research describing animal abuse as a possible indicator and predictor of interpersonal violence. Five steps that helped build human health care’s response to child abuse, domestic violence, and elder abuse, and that are analogous to forces in contemporary veterinary practice, are described. It familiarizes practitioners with terminology used in animal cruelty investigations. It describes clinical presentations, client profiles and behaviors, and environmental conditions that may raise a practitioner’s index of suspicion of possible animal maltreatment. It reviews protocols that practitioners may employ to respond compassionately and effectively to suspected animal abuse and enhance successful law enforcement investigations and prosecutions. Such responses can unite human and veterinary medicine in a common concern for vulnerable, victimized, and at-risk populations and position veterinarians as an essential part of public health approaches to break the cycles of violence affecting animals and human members of the family and community. Keywords: animal cruelty, animal abuse, neglect, reporting, animal welfare, domestic

  6. What is the animal doing? Tools for exploring behavioural structure in animal movements.

    Science.gov (United States)

    Gurarie, Eliezer; Bracis, Chloe; Delgado, Maria; Meckley, Trevor D; Kojola, Ilpo; Wagner, C Michael

    2016-01-01

    Movement data provide a window - often our only window - into the cognitive, social and biological processes that underlie the behavioural ecology of animals in the wild. Robust methods for identifying and interpreting distinct modes of movement behaviour are of great importance, but complicated by the fact that movement data are complex, multivariate and dependent. Many different approaches to exploratory analysis of movement have been developed to answer similar questions, and practitioners are often at a loss for how to choose an appropriate tool for a specific question. We apply and compare four methodological approaches: first passage time (FPT), Bayesian partitioning of Markov models (BPMM), behavioural change point analysis (BCPA) and a fitted multistate random walk (MRW) to three simulated tracks and two animal trajectories - a sea lamprey (Petromyzon marinus) tracked for 12 h and a wolf (Canis lupus) tracked for 1 year. The simulations - in which, respectively, velocity, tortuosity and spatial bias change - highlight the sensitivity of all methods to model misspecification. Methods that do not account for autocorrelation in the movement variables lead to spurious change points, while methods that do not account for spatial bias completely miss changes in orientation. When applied to the animal data, the methods broadly agree on the structure of the movement behaviours. Important discrepancies, however, reflect differences in the assumptions and nature of the outputs. Important trade-offs are between the strength of the a priori assumptions (low in BCPA, high in MRW), complexity of output (high in the BCPA, low in the BPMM and MRW) and explanatory potential (highest in the MRW). The animal track analysis suggests some general principles for the exploratory analysis of movement data, including ways to exploit the strengths of the various methods. We argue for close and detailed exploratory analysis of movement before fitting complex movement models.

  7. On the venom system of centipedes (Chilopoda), a neglected group of venomous animals.

    Science.gov (United States)

    Undheim, Eivind A B; King, Glenn F

    2011-03-15

    Centipedes are among the oldest extant terrestrial arthropods and are an ecologically important group of soil and leaf litter predators. Despite their abundance and frequent, often painful, encounters with humans, little is known about the venom and venom apparatus of centipedes, although it is apparent that these are both quite different from other venomous lineages. The venom gland can be regarded as an invaginated cuticle and epidermis, consisting of numerous epithelial secretory units each with its own unique valve-like excretory system. The venom contains several different enzymes, but is strikingly different to most other arthropods in that metalloproteases appear to be important. Myotoxic, cardiotoxic, and neurotoxic activities have been described, most of which have been attributed to high molecular weight proteins. Neurotoxic activities are also unusual in that G-protein coupled receptors often seem to be involved, either directly as targets of neurotoxins or indirectly by activating endogenous agonists. These relatively slow responses may be complemented by the rapid effects caused by histamines present in the venom and from endogenous release of histamines induced by venom cytotoxins. The differences probably reflect the ancient and independent evolutionary history of the centipede venom system, although they may also be somewhat exaggerated by the paucity of information available on this largely neglected group.

  8. Animal social networks as substrate for cultural behavioural diversity.

    Science.gov (United States)

    Whitehead, Hal; Lusseau, David

    2012-02-07

    We used individual-based stochastic models to examine how social structure influences the diversity of socially learned behaviour within a non-human population. For continuous behavioural variables we modelled three forms of dyadic social learning, averaging the behavioural value of the two individuals, random transfer of information from one individual to the other, and directional transfer from the individual with highest behavioural value to the other. Learning had potential error. We also examined the transfer of categorical behaviour between individuals with random directionality and two forms of error, the adoption of a randomly chosen existing behavioural category or the innovation of a new type of behaviour. In populations without social structuring the diversity of culturally transmitted behaviour increased with learning error and population size. When the populations were structured socially either by making individuals members of permanent social units or by giving them overlapping ranges, behavioural diversity increased with network modularity under all scenarios, although the proportional increase varied considerably between continuous and categorical behaviour, with transmission mechanism, and population size. Although functions of the form e(c)¹(m)⁻(c)² + (c)³(Log(N)) predicted the mean increase in diversity with modularity (m) and population size (N), behavioural diversity could be highly unpredictable both between simulations with the same set of parameters, and within runs. Errors in social learning and social structuring generally promote behavioural diversity. Consequently, social learning may be considered to produce culture in populations whose social structure is sufficiently modular.

  9. Lateralized loss of biting attack-patterned reflexes following induction of contralateral sensory neglect in the cat: a possible role for the striatum in centrally elicited aggressive behaviour.

    Science.gov (United States)

    Bandler, R; Halliday, R

    1982-06-17

    A syndrome of "contralateral sensory neglect' was induced by hypothalamic knife cuts in 6 of 10 cats in which quiet biting attack behaviour could be elicited by lateral hypothalamic stimulation. The contralateral sensory neglect in the 6 affected cats was accompanied by a loss on the "neglected' side of the body of the patterned reflexes which mediate positioning of the head to bite and the jaw-opening component of biting. As a result, when these cats were stimulated in the lateral hypothalamus, although they continued to approach and even make tactile contact with the rat, they generally failed to bite it. Analysis of the histological and behavioural data suggested that damage to the nigrostriatal and/or striato/pallidonigral fibre systems provided the likely basis for both the induction of the contralateral sensory neglect and the lateralized patterned reflex loss. It was suggested, with respect to these specific patterned reflex components of the attack, that an important contribution may be made by the striatum.

  10. Animal personality and state-behaviour feedbacks: a review and guide for empiricists.

    Science.gov (United States)

    Sih, Andrew; Mathot, Kimberley J; Moirón, María; Montiglio, Pierre-Olivier; Wolf, Max; Dingemanse, Niels J

    2015-01-01

    An exciting area in behavioural ecology focuses on understanding why animals exhibit consistent among-individual differences in behaviour (animal personalities). Animal personality has been proposed to emerge as an adaptation to individual differences in state variables, leading to the question of why individuals differ consistently in state. Recent theory emphasizes the role that positive feedbacks between state and behaviour can play in producing consistent among-individual covariance between state and behaviour, hence state-dependent personality. We review the role of feedbacks in recent models of adaptive personalities, and provide guidelines for empirical testing of model assumptions and predictions. We discuss the importance of the mediating effects of ecology on these feedbacks, and provide a roadmap for including state-behaviour feedbacks in behavioural ecology research.

  11. Adding 'epi-' to behaviour genetics: implications for animal domestication.

    Science.gov (United States)

    Jensen, Per

    2015-01-01

    In this review, it is argued that greatly improved understanding of domestication may be gained from extending the field of behaviour genetics to also include epigenetics. Domestication offers an interesting framework of rapid evolutionary changes caused by well-defined selection pressures. Behaviour is an important phenotype in this context, as it represents the primary means of response to environmental challenges. An overview is provided of the evidence for genetic involvement in behavioural control and the presently used methods for finding so-called behaviour genes. This shows that evolutionary changes in behaviour are to a large extent correlated to changes in patterns of gene expression, which brings epigenetics into the focus. This area is concerned with the mechanisms controlling the timing and extent of gene expression, and a lot of focus has been placed on methylation of cytosine in promoter regions, usually associated with genetic downregulation. The review considers the available evidence that environmental input, for example stress, can modify methylation and other epigenetic marks and subsequently affect behaviour. Furthermore, several studies are reviewed, demonstrating that acquired epigenetic modifications can be inherited and cause trans-generational behaviour changes. In conclusion, epigenetics may signify a new paradigm in this respect, as it shows that genomic modifications can be caused by environmental signals, and random mutations in DNA sequence are therefore not the only sources of heritable genetic variation.

  12. Epigenesis of behavioural lateralization in humans and other animals

    NARCIS (Netherlands)

    Schaafsma, S. M.; Riedstra, B. J.; Pfannkuche, K. A.; Bouma, A.; Groothuis, T. G. G.

    2009-01-01

    Despite several decades of research, the epigenesis of behavioural and brain lateralization is still elusive, although its knowledge is important in understanding developmental plasticity, function and evolution of lateralization, and its relationship with developmental disorders. Over the last deca

  13. Monitoring Animal Behaviour and Environmental Interactions Using Wireless Sensor Networks, GPS Collars and Satellite Remote Sensing

    Directory of Open Access Journals (Sweden)

    Peter Corke

    2009-05-01

    Full Text Available Remote monitoring of animal behaviour in the environment can assist in managing both the animal and its environmental impact. GPS collars which record animal locations with high temporal frequency allow researchers to monitor both animal behaviour and interactions with the environment. These ground-based sensors can be combined with remotely-sensed satellite images to understand animal-landscape interactions. The key to combining these technologies is communication methods such as wireless sensor networks (WSNs. We explore this concept using a case-study from an extensive cattle enterprise in northern Australia and demonstrate the potential for combining GPS collars and satellite images in a WSN to monitor behavioural preferences and social behaviour of cattle.

  14. Characterization of microRNAs from Orientobilharzia turkestanicum, a neglected blood fluke of human and animal health significance.

    Science.gov (United States)

    Wang, Chun-Ren; Xu, Min-Jun; Fu, Jing-Hua; Nisbet, Alasdair J; Chang, Qiao-Cheng; Zhou, Dong-Hui; Huang, Si-Yang; Zou, Feng-Cai; Zhu, Xing-Quan

    2012-01-01

    The neglected blood flukes Orientobilharzia spp. belonging to the Platyhelminthes, infect animals in a number of countries of the world, and cause cercarial dermatitis in humans, as well as significant diseases and even death in economically-important animals. MicroRNAs (miRNAs) are now considered to be a key mechanism of gene regulation. Herein, we investigated the global miRNA expression profile of adult O. turkestanicum using next-generation sequencing technology and real-time quantitative PCR, to gain further information on the role of these molecules in host invasion and the parasitic lifestyle of this species. A total of 13.48 million high quality reads were obtained out of 13.78 million raw sequencing reads, with 828 expressed miRNAs identified. Phylogenetic analysis showed that the miRNAs of O. turkestanicum were still rapidly evolving and there was a "directed mutation" pattern compared with that of other species. Target mRNAs were successfully predicted to 518 miRNAs. These targets included energy metabolism, transcription initiation factors, signal transduction, growth factor receptors. miRNAs targeting egg proteins, including major egg antigen p40, and heat shock proteins were also found. Enrichment analysis indicated enrichment for mRNAs involved in catalytic, binding, transcription regulators and translation regulators. The present study represented the first large-scale characterization of O. turkestanicum miRNAs, which provides novel resources for better understanding the complex biology of this zoonotic parasite, which, in turn, has implications for the effective control of the disease it causes.

  15. Characterization of microRNAs from Orientobilharzia turkestanicum, a neglected blood fluke of human and animal health significance.

    Directory of Open Access Journals (Sweden)

    Chun-Ren Wang

    Full Text Available The neglected blood flukes Orientobilharzia spp. belonging to the Platyhelminthes, infect animals in a number of countries of the world, and cause cercarial dermatitis in humans, as well as significant diseases and even death in economically-important animals. MicroRNAs (miRNAs are now considered to be a key mechanism of gene regulation. Herein, we investigated the global miRNA expression profile of adult O. turkestanicum using next-generation sequencing technology and real-time quantitative PCR, to gain further information on the role of these molecules in host invasion and the parasitic lifestyle of this species. A total of 13.48 million high quality reads were obtained out of 13.78 million raw sequencing reads, with 828 expressed miRNAs identified. Phylogenetic analysis showed that the miRNAs of O. turkestanicum were still rapidly evolving and there was a "directed mutation" pattern compared with that of other species. Target mRNAs were successfully predicted to 518 miRNAs. These targets included energy metabolism, transcription initiation factors, signal transduction, growth factor receptors. miRNAs targeting egg proteins, including major egg antigen p40, and heat shock proteins were also found. Enrichment analysis indicated enrichment for mRNAs involved in catalytic, binding, transcription regulators and translation regulators. The present study represented the first large-scale characterization of O. turkestanicum miRNAs, which provides novel resources for better understanding the complex biology of this zoonotic parasite, which, in turn, has implications for the effective control of the disease it causes.

  16. Genetics and Genomics of Animal Behaviour and Welfare - Challanges and possibilities

    DEFF Research Database (Denmark)

    Jensen, Per; Buitenhuis, Bart; Kjaer, Joergen

    2008-01-01

    Traditionally, the contribution of applied ethology to animal welfare science has concentrated on understanding the reactions of animals to their housing conditions. Domestication has had small effects on fundamental aspects of animal behaviour, and therefore, the needs of present day domesticated...

  17. From Sensor Data to Animal Behaviour: An Oystercatcher Example

    NARCIS (Netherlands)

    Shamoun-Baranes, J.; Bom, R.; van Loon, E.E.; Ens, B.J.; Oosterbeek, K.; Bouten, W.

    2012-01-01

    Animal-borne sensors enable researchers to remotely track animals, their physiological state and body movements. Accelerometers, for example, have been used in several studies to measure body movement, posture, and energy expenditure, although predominantly in marine animals. In many studies, behavi

  18. From sensor data to animal behaviour: an oystercatcher example

    NARCIS (Netherlands)

    Shamoun-Baranes, J.; Bom, R.; van Loon, E.E.; Ens, B.J.; Oosterbeek, K.; Bouten, W.

    2012-01-01

    Animal-borne sensors enable researchers to remotely track animals, their physiological state and body movements. Accelerometers, for example, have been used in several studies to measure body movement, posture, and energy expenditure, although predominantly in marine animals. In many studies, behavi

  19. Animal welfare: What are the relationships between physiological and behavioural measures of adaptation?

    NARCIS (Netherlands)

    Richard, S.; Auperin, B.; Bolhuis, J.E.; Geverink, N.A.; Jones, B.C.; Lepage, O.; Mignon-Grasteau, S.; Mormede, P.; Prunet, P.; Beaumont, C.

    2007-01-01

    Assessing the behavioural adaptation of an animal to its environment is complex, notably because numerous criteria can be taken into consideration. A better understanding of the relationships between criteria, particularly between behavioural and physiological respon-ses, might help reduce the numbe

  20. Deriving Animal Behaviour from High-Frequency GPS: Tracking Cows in Open and Forested Habitat.

    Science.gov (United States)

    de Weerd, Nelleke; van Langevelde, Frank; van Oeveren, Herman; Nolet, Bart A; Kölzsch, Andrea; Prins, Herbert H T; de Boer, W Fred

    2015-01-01

    The increasing spatiotemporal accuracy of Global Navigation Satellite Systems (GNSS) tracking systems opens the possibility to infer animal behaviour from tracking data. We studied the relationship between high-frequency GNSS data and behaviour, aimed at developing an easily interpretable classification method to infer behaviour from location data. Behavioural observations were carried out during tracking of cows (Bos Taurus) fitted with high-frequency GPS (Global Positioning System) receivers. Data were obtained in an open field and forested area, and movement metrics were calculated for 1 min, 12 s and 2 s intervals. We observed four behaviour types (Foraging, Lying, Standing and Walking). We subsequently used Classification and Regression Trees to classify the simultaneously obtained GPS data as these behaviour types, based on distances and turning angles between fixes. GPS data with a 1 min interval from the open field was classified correctly for more than 70% of the samples. Data from the 12 s and 2 s interval could not be classified successfully, emphasizing that the interval should be long enough for the behaviour to be defined by its characteristic movement metrics. Data obtained in the forested area were classified with a lower accuracy (57%) than the data from the open field, due to a larger positional error of GPS locations and differences in behavioural performance influenced by the habitat type. This demonstrates the importance of understanding the relationship between behaviour and movement metrics, derived from GNSS fixes at different frequencies and in different habitats, in order to successfully infer behaviour. When spatially accurate location data can be obtained, behaviour can be inferred from high-frequency GNSS fixes by calculating simple movement metrics and using easily interpretable decision trees. This allows for the combined study of animal behaviour and habitat use based on location data, and might make it possible to detect deviations

  1. Experimental evidence for inherent Lévy search behaviour in foraging animals

    NARCIS (Netherlands)

    Kölzsch, A.; Alzate, A.; Bartumeus, F.; de Jager, M.; Weerman, E.; Hengeveld, G.M.; Naguib, M.; Nolet, B.A.; Van de Koppel, J.

    2015-01-01

    Recently, Lévy walks have been put forward as a new paradigm for animal search and many cases have been made for its presence in nature. However, it remains debated whether Lévy walks are an inherent behavioural strategy or emerge from the animal reacting to its habitat. Here, we demonstrate signatu

  2. High in situ repeatability of behaviour indicates animal personality in the beadlet anemone Actinia equina (Cnidaria.

    Directory of Open Access Journals (Sweden)

    Mark Briffa

    Full Text Available 'Animal personality' means that individuals differ from one another in either single behaviours or suites of related behaviours in a way that is consistent over time. It is usually assumed that such consistent individual differences in behaviour are driven by variation in how individuals respond to information about their environment, rather than by differences in external factors such as variation in microhabitat. Since behavioural variation is ubiquitous in nature we might expect 'animal personality' to be present in diverse taxa, including animals with relatively simple nervous systems. We investigated in situ startle responses in a sea anemone, Actinia equina, to determine whether personalities might be present in this example of an animal with a simple nervous system. We found very high levels of repeatability among individuals that were re-identified in the same locations over a three week sampling period. In a subset of the data, where we used tide-pool temperature measurements to control for a key element of variation in microhabitat, these high levels of repeatability remained. Although a range of other consistent differences in micro-habitat features could have contributed to consistent differences between the behaviour of individuals, these data suggest the presence of animal personality in A. equina. Rather than being restricted to certain groups, personality may be a general feature of animals and may be particularly pronounced in species with simple nervous systems.

  3. High in situ repeatability of behaviour indicates animal personality in the beadlet anemone Actinia equina (Cnidaria).

    Science.gov (United States)

    Briffa, Mark; Greenaway, Julie

    2011-01-01

    'Animal personality' means that individuals differ from one another in either single behaviours or suites of related behaviours in a way that is consistent over time. It is usually assumed that such consistent individual differences in behaviour are driven by variation in how individuals respond to information about their environment, rather than by differences in external factors such as variation in microhabitat. Since behavioural variation is ubiquitous in nature we might expect 'animal personality' to be present in diverse taxa, including animals with relatively simple nervous systems. We investigated in situ startle responses in a sea anemone, Actinia equina, to determine whether personalities might be present in this example of an animal with a simple nervous system. We found very high levels of repeatability among individuals that were re-identified in the same locations over a three week sampling period. In a subset of the data, where we used tide-pool temperature measurements to control for a key element of variation in microhabitat, these high levels of repeatability remained. Although a range of other consistent differences in micro-habitat features could have contributed to consistent differences between the behaviour of individuals, these data suggest the presence of animal personality in A. equina. Rather than being restricted to certain groups, personality may be a general feature of animals and may be particularly pronounced in species with simple nervous systems.

  4. High CO₂ and marine animal behaviour: potential mechanisms and ecological consequences.

    Science.gov (United States)

    Briffa, Mark; de la Haye, Kate; Munday, Philip L

    2012-08-01

    Exposure to pollution and environmental change can alter the behaviour of aquatic animals and here we review recent evidence that exposure to elevated CO₂ and reduced sea water pH alters the behaviour of tropical reef fish and hermit crabs. Three main routes through which behaviour might be altered are discussed; elevated metabolic load, 'info-disruption' and avoidance behaviour away from polluted locations. There is clear experimental evidence that exposure to high CO₂ disrupts the ability to find settlement sites and shelters, the ability to detect predators and the ability to detect prey and food. In marine vertebrates and marine crustaceans behavioural change appears to occur via info-disruption. In hermit crabs and other crustaceans impairment of performance capacities might also play a role. We discuss the implications for such behavioural changes in terms of potential impacts at the levels of population health and ecosystem services, and consider future directions for research.

  5. Estimating animal behaviour and residency from movement data

    DEFF Research Database (Denmark)

    Pedersen, Martin Wæver; Patterson, Toby Alexander; Thygesen, Uffe Høgsbro

    2011-01-01

    probability distribution of location and behavior at each point in time. With this, the behavioral state of the animal can be associated to regions in space, thus revealing migration corridors and residence areas. We demonstrate the inferential potential of the method by analyzing satellite-linked archival...

  6. Linking animal population dynamics to alterations in foraging behaviour

    DEFF Research Database (Denmark)

    Nabe-Nielsen, Jacob; Sibly, Richard; Tougaard, Jakob;

    was not jeopardized even when disturbances were simulated to have a relatively large and persistent effect on the behavior of individual animals. Porpoises were simulated to move away from noisy objects, preventing them from returning to the known food patches in that area. This resulted in decreasing energy reserves...... to disturbances by moving away are prevented from accessing the food in the disturbed areas and may also be prevented from dispersing among areas where food is available at different times of the year. Such disturbance effects may play a particularly large role for marine mammals that live in environments...... realistic movement patterns in scenarios where animals were not exposed to noise. Results/Conclusions The main results of the study were that the effects of disturbances were highly dependent on how fast the food recovered after being eaten, but that the long-term survival of the population...

  7. Animal-assisted therapy with children suffering from insecure attachment due to abuse and neglect: a method to lower the risk of intergenerational transmission of abuse?

    Science.gov (United States)

    Parish-Plass, Nancy

    2008-01-01

    Children suffering from insecure attachment due to severe abuse and/or neglect are often characterized by internal working models which, although perhaps adaptive within the original family situation, are inappropriate and maladaptive in other relationships and situations. Such children have a higher probability than the general population of becoming abusing or neglecting parents. Besides the usual goals of psychotherapy, an overall goal is to stop the cycle of abuse in which abused children may grow up to be abusing parents. Therapy with these children is complicated by their distrust in adults as well as difficulties in symbolization due to trauma during the preverbal stage. Animal-Assisted Therapy (AAT) provides avenues for circumventing these difficulties, as well as providing additional tools for reaching the inner world of the client. This article gives a brief background of the connection between insecure attachment and intergenerational transmission of abuse and neglect as well as a brief overview of the principles of AAT in a play therapy setting. A rationale for the use of AAT as a unique therapy technique for children having suffered from abuse and neglect is followed by a number of clinical examples illustrating AAT.

  8. Quick, Accurate, Smart: 3D Computer Vision Technology Helps Assessing Confined Animals' Behaviour.

    Science.gov (United States)

    Barnard, Shanis; Calderara, Simone; Pistocchi, Simone; Cucchiara, Rita; Podaliri-Vulpiani, Michele; Messori, Stefano; Ferri, Nicola

    2016-01-01

    Mankind directly controls the environment and lifestyles of several domestic species for purposes ranging from production and research to conservation and companionship. These environments and lifestyles may not offer these animals the best quality of life. Behaviour is a direct reflection of how the animal is coping with its environment. Behavioural indicators are thus among the preferred parameters to assess welfare. However, behavioural recording (usually from video) can be very time consuming and the accuracy and reliability of the output rely on the experience and background of the observers. The outburst of new video technology and computer image processing gives the basis for promising solutions. In this pilot study, we present a new prototype software able to automatically infer the behaviour of dogs housed in kennels from 3D visual data and through structured machine learning frameworks. Depth information acquired through 3D features, body part detection and training are the key elements that allow the machine to recognise postures, trajectories inside the kennel and patterns of movement that can be later labelled at convenience. The main innovation of the software is its ability to automatically cluster frequently observed temporal patterns of movement without any pre-set ethogram. Conversely, when common patterns are defined through training, a deviation from normal behaviour in time or between individuals could be assessed. The software accuracy in correctly detecting the dogs' behaviour was checked through a validation process. An automatic behaviour recognition system, independent from human subjectivity, could add scientific knowledge on animals' quality of life in confinement as well as saving time and resources. This 3D framework was designed to be invariant to the dog's shape and size and could be extended to farm, laboratory and zoo quadrupeds in artificial housing. The computer vision technique applied to this software is innovative in non

  9. Quick, Accurate, Smart: 3D Computer Vision Technology Helps Assessing Confined Animals' Behaviour.

    Directory of Open Access Journals (Sweden)

    Shanis Barnard

    Full Text Available Mankind directly controls the environment and lifestyles of several domestic species for purposes ranging from production and research to conservation and companionship. These environments and lifestyles may not offer these animals the best quality of life. Behaviour is a direct reflection of how the animal is coping with its environment. Behavioural indicators are thus among the preferred parameters to assess welfare. However, behavioural recording (usually from video can be very time consuming and the accuracy and reliability of the output rely on the experience and background of the observers. The outburst of new video technology and computer image processing gives the basis for promising solutions. In this pilot study, we present a new prototype software able to automatically infer the behaviour of dogs housed in kennels from 3D visual data and through structured machine learning frameworks. Depth information acquired through 3D features, body part detection and training are the key elements that allow the machine to recognise postures, trajectories inside the kennel and patterns of movement that can be later labelled at convenience. The main innovation of the software is its ability to automatically cluster frequently observed temporal patterns of movement without any pre-set ethogram. Conversely, when common patterns are defined through training, a deviation from normal behaviour in time or between individuals could be assessed. The software accuracy in correctly detecting the dogs' behaviour was checked through a validation process. An automatic behaviour recognition system, independent from human subjectivity, could add scientific knowledge on animals' quality of life in confinement as well as saving time and resources. This 3D framework was designed to be invariant to the dog's shape and size and could be extended to farm, laboratory and zoo quadrupeds in artificial housing. The computer vision technique applied to this software is

  10. [Environmental uncertainty and arousal/stress as the direct determinants of animal behaviour].

    Science.gov (United States)

    Popov, S V

    2010-01-01

    A model of direct behavioural mechanisms is suggested. The suggestion is founded on the following prerequisites: the law of optimum arousal by Yerkes-Dodson; the data on animals' purposeful striving towards the optimum; and the data on effect of stimuli uncertainty (unpredictability and/or uncontrollability) on susceptibility to the stimuli. The key postulate of the model is animals' ability to affect the environment uncertainty with their behaviour and, hence, to change their susceptibility to various stimuli and optimize their stress/arousal level. This function of behaviour had never been discussed and seems to be rather important for proximal behavioural mechanisms and for forming direct motives of behaviour. Optimization of arousal level may be viewed as "universal benefit" at the level of direct behavioural mechanisms (similar to "joint genetic fitness" at the level of evolutional mechanisms). Within the model framework it is possible to take up some sophisticated aspects of ethology such as social relations forming, "begging for punishment", "zoo stereotypy", and so on. Among verifiable predictions that can be derived from its analysis, the following ones are worthwhile: (1) the stronger of two similar social relations cannot be more stressful than the weaker one; (2) the intensity of marking activity never increases as arousal/stress level decreases; (3) stress/arousal level of an animal having been experienced "zoo stereotypy" for a long time can never be higher than that of a conspecific individual showing the behaviour for the first time; (4) the rate of "begging for punishment" behaviour of an individual should positively correlate with environmental uncertainty; (5) arousal/stress level of an individual looking for novelty can never be higher than arousal/stress level of the same individual when avoiding novelty; (6) the striving of a specimen for displaying the behaviour promoting an increase in uncertainty can be suppressed by raising the

  11. Role of etology in detecting environmental pollutants that affect changes in animal behaviour

    Directory of Open Access Journals (Sweden)

    Vučinić Marijana M.

    2005-01-01

    Full Text Available A large number of chemical pollutants originating from industrial agricultural and urban through the direct or indirect disruption of endocrine gland and hormone function. That is why these pollutants are known as endocrine-disrupting chemicals (EDC. By disrupting endocrine function, the EDC change certain forms of animal behaviour. This is why a direct link can be established between etology, as a scientific discipline that studied the role, function, ontogenetic and evolutionary development of behaviour from the aspect of the animal's adaption to living conditions, and ecotoxicology. In this mutual connection, the role of etology is to identify changes in animal behaviour which will serve as the first bioindicator of the presence of EDC in a certain environment, and before the occurrence of organic changes that could have lethal consequences.

  12. Multi-objective behavioural mechanisms are adopted by foraging animals to achieve several optimality goals simultaneously.

    Science.gov (United States)

    Wajnberg, Eric

    2012-03-01

    1. Animals foraging for resources are under a variety of selective pressures, and separate optimality models have been developed predicting the optimal reproductive strategies they should adopt. 2. In most cases, the proximate behavioural mechanisms adopted to achieve such optimality goals have been identified. This is the case, for example, for optimal patch time and sex allocation in insect parasitoids. However, behaviours modelled within this framework have mainly been studied separately, even though real animals have to optimize some behaviours simultaneously. 3. For this reason, it would be better if proximate behavioural rules were designed to attain several goals simultaneously. Despite their importance, such multi-objective proximate rules remain to be discovered. 4. Based on experiments on insect parasitoids that simultaneously examine their optimal patch time and sex allocation strategies, it is shown here that animals can adopt multi-objective behavioural mechanisms that appear consistent with the two optimal goals simultaneously. 5. Results of computer simulations demonstrate that these behavioural mechanisms are indeed consistent with optimal reproductive strategies and have thus been most likely selected over the course of the evolutionary time.

  13. Effect of drugs of abuse on social behaviour: a review of animal models.

    Science.gov (United States)

    Blanco-Gandía, Maria C; Mateos-García, Ana; García-Pardo, Maria P; Montagud-Romero, Sandra; Rodríguez-Arias, Marta; Miñarro, José; Aguilar, María A

    2015-09-01

    Social behaviour is disturbed in many substance abuse and psychiatric disorders. Given the consensus that social behaviours of lower mammals may help to understand some human emotional reactions, the aim of the present work was to provide an up-to-date review of studies on the changes in social behaviour induced by drugs of abuse. Various animal models have been used to study the relationship between drugs of abuse and social behaviour. Herein, we describe the effects of different substances of abuse on the three most commonly used animal models of social behaviour: the social play test, the social interaction test and the resident-intruder paradigm. The first is the most widely used test to assess adolescent behaviour in rodents, the second is generally used to evaluate a wide repertoire of behaviours in adulthood and the latter is specific to aggressive behaviour. Throughout the review we will explore the most relevant studies carried out to date to evaluate the effects of alcohol, cocaine, opioids, 3,4-methylenedioxymethamphetamine (MDMA), cannabinoids, nicotine and other drugs of abuse on these three paradigms, taking into account the influence of different variables, such as social history, age and type of exposure. Drugs of diverse pharmacological classes induce alterations in social behaviour, although they can be contrasting depending on several factors (drug, individual differences and environmental conditions). Ethanol and nicotine increase social interaction at low doses but reduce it at high doses. Psychostimulants, MDMA and cannabinoids reduce social interaction, whereas opiates increase it. Ethanol and psychostimulants enhance aggression, whereas MDMA, opiates, cannabinoids and nicotine reduce it. Prenatal drug exposure alters social behaviour, whereas drug withdrawal decreases sociability and enhances aggression. As a whole, this evidence has improved our understanding of the social dimension of drug addiction.

  14. Movement activity based classification of animal behaviour with an application to data from cheetah (Acinonyx jubatus.

    Directory of Open Access Journals (Sweden)

    Steffen Grünewälder

    Full Text Available We propose a new method, based on machine learning techniques, for the analysis of a combination of continuous data from dataloggers and a sampling of contemporaneous behaviour observations. This data combination provides an opportunity for biologists to study behaviour at a previously unknown level of detail and accuracy; however, continuously recorded data are of little use unless the resulting large volumes of raw data can be reliably translated into actual behaviour. We address this problem by applying a Support Vector Machine and a Hidden-Markov Model that allows us to classify an animal's behaviour using a small set of field observations to calibrate continuously recorded activity data. Such classified data can be applied quantitatively to the behaviour of animals over extended periods and at times during which observation is difficult or impossible. We demonstrate the usefulness of the method by applying it to data from six cheetah (Acinonyx jubatus in the Okavango Delta, Botswana. Cumulative activity data scores were recorded every five minutes by accelerometers embedded in GPS radio-collars for around one year on average. Direct behaviour sampling of each of the six cheetah were collected in the field for comparatively short periods. Using this approach we are able to classify each five minute activity score into a set of three key behaviour (feeding, mobile and stationary, creating a continuous behavioural sequence for the entire period for which the collars were deployed. Evaluation of our classifier with cross-validation shows the accuracy to be 83%-94%, but that the accuracy for individual classes is reduced with decreasing sample size of direct observations. We demonstrate how these processed data can be used to study behaviour identifying seasonal and gender differences in daily activity and feeding times. Results given here are unlike any that could be obtained using traditional approaches in both accuracy and detail.

  15. Movement activity based classification of animal behaviour with an application to data from cheetah (Acinonyx jubatus).

    Science.gov (United States)

    Grünewälder, Steffen; Broekhuis, Femke; Macdonald, David Whyte; Wilson, Alan Martin; McNutt, John Weldon; Shawe-Taylor, John; Hailes, Stephen

    2012-01-01

    We propose a new method, based on machine learning techniques, for the analysis of a combination of continuous data from dataloggers and a sampling of contemporaneous behaviour observations. This data combination provides an opportunity for biologists to study behaviour at a previously unknown level of detail and accuracy; however, continuously recorded data are of little use unless the resulting large volumes of raw data can be reliably translated into actual behaviour. We address this problem by applying a Support Vector Machine and a Hidden-Markov Model that allows us to classify an animal's behaviour using a small set of field observations to calibrate continuously recorded activity data. Such classified data can be applied quantitatively to the behaviour of animals over extended periods and at times during which observation is difficult or impossible. We demonstrate the usefulness of the method by applying it to data from six cheetah (Acinonyx jubatus) in the Okavango Delta, Botswana. Cumulative activity data scores were recorded every five minutes by accelerometers embedded in GPS radio-collars for around one year on average. Direct behaviour sampling of each of the six cheetah were collected in the field for comparatively short periods. Using this approach we are able to classify each five minute activity score into a set of three key behaviour (feeding, mobile and stationary), creating a continuous behavioural sequence for the entire period for which the collars were deployed. Evaluation of our classifier with cross-validation shows the accuracy to be 83%-94%, but that the accuracy for individual classes is reduced with decreasing sample size of direct observations. We demonstrate how these processed data can be used to study behaviour identifying seasonal and gender differences in daily activity and feeding times. Results given here are unlike any that could be obtained using traditional approaches in both accuracy and detail.

  16. Analysing animal behaviour in wildlife videos using face detection and tracking

    OpenAIRE

    2006-01-01

    An algorithm that categorises animal locomotive behaviour by combining detection and tracking of animal faces in wildlife videos is presented. As an example, the algorithm is applied to lion faces. The detection algorithm is based on a human face detection method, utilising Haar-like features and AdaBoost classifiers. The face tracking is implemented by applying a specific interest model that combines low-level feature tracking with the detection algorithm. By combining the two methods in a s...

  17. Friends of friends: are indirect connections in social networks important to animal behaviour?

    Science.gov (United States)

    Brent, Lauren J N

    2015-05-01

    Friend of a friend relationships, or the indirect connections between people, influence our health, well-being, financial success and reproductive output. As with humans, social behaviours in other animals often occur within a broad interconnected network of social ties. Yet studies of animal social behaviour tend to focus on associations between pairs of individuals. With the increase in popularity of social network analysis, researchers have started to look beyond the dyad to examine the role of indirect connections in animal societies. Here, I provide an overview of the new knowledge that has been uncovered by these studies. I focus on research that has addressed both the causes of social behaviours, i.e. the cognitive and genetic basis of indirect connections, as well as their consequences, i.e. the impact of indirect connections on social cohesion, information transfer, cultural practices and fitness. From these studies, it is apparent that indirect connections play an important role in animal behaviour, although future research is needed to clarify their contribution.

  18. The impact of group size on damaging behaviours, aggression, fear and stress in farm animals

    NARCIS (Netherlands)

    Rodenburg, T.B.; Koene, P.

    2007-01-01

    The aim of this review is to discuss the impact of group size on damaging behaviours, aggression, fear and stress in farm animals and to identify housing- and management options that can help to reduce problems caused by suboptimal group sizes. Increasing group size was found to increase the risk of

  19. Animal Behaviour Fieldwork: Introducing Psychology Students to the Process of Science

    Science.gov (United States)

    Dickins, Thomas E.; Donovan, Peter

    2012-01-01

    In this paper we discuss the development and running of a residential animal behaviour field trip. The trip has a number of elements that challenge and develop the students. First, this trip is open to students at levels two, three and M. This allows us to engineer a certain amount of peer assisted learning. Second, the students live together and…

  20. A Knockout Experiment: Disciplinary Divides and Experimental Skill in Animal Behaviour Genetics.

    Science.gov (United States)

    Nelson, Nicole C

    2015-07-01

    In the early 1990s, a set of new techniques for manipulating mouse DNA allowed researchers to 'knock out' specific genes and observe the effects of removing them on a live mouse. In animal behaviour genetics, questions about how to deploy these techniques to study the molecular basis of behaviour became quite controversial, with a number of key methodological issues dissecting the interdisciplinary research field along disciplinary lines. This paper examines debates that took place during the 1990s between a predominately North American group of molecular biologists and animal behaviourists around how to design, conduct, and interpret behavioural knockout experiments. Drawing from and extending Harry Collins's work on how research communities negotiate what counts as a 'well-done experiment,' I argue that the positions practitioners took on questions of experimental skill reflected not only the experimental traditions they were trained in but also their differing ontological and epistemological commitments. Different assumptions about the nature of gene action, eg., were tied to different positions in the knockout mouse debates on how to implement experimental controls. I conclude by showing that examining representations of skill in the context of a community's knowledge commitments sheds light on some of the contradictory ways in which contemporary animal behaviour geneticists talk about their own laboratory work as a highly skilled endeavour that also could be mechanised, as easy to perform and yet difficult to perform well.

  1. Conceptual framework alignment between primary literature and education in animal behaviour

    Science.gov (United States)

    Bierema, Andrea Marie-Kryger

    In 1963, Tinbergen revolutionized the study of animal behaviour in his paper On aims and methods of ethology (Zeitschrift Tierpsycholgie, 20, 410-433) by revamping the conceptual framework of the discipline. His framework suggests an integration of four questions: causation, ontogeny, survival value, and evolution. The National Research Council Committee (U.S.) on Undergraduate Biology Education to Prepare Research Scientists for the 21st Century published BIO2010: Transforming Undergraduate Education for Future Research Biologists (Washington, DC: The National Academies Press, 2003), which suggests alignment between current research and undergraduate education. Unfortunately, alignment has been rarely studied in college biology, especially for fundamental concepts. The purpose of this study, therefore, is to determine if the conceptual framework used by animal behaviour scientists, as presented in current primary literature, aligns with what students are exposed to in undergraduate biology education. After determining the most commonly listed textbooks from randomlyselected animal behaviour syllabi, four of the most popular textbooks, as well as the course descriptions provided in the collected syllabi, underwent content analysis in order to determine the extent that each of Tinbergen's four questions is being applied in education. Mainstream animal behaviour journal articles from 2013 were also assessed via content analysis in order to evaluate the current research framework. It was discovered that over 80% of the textbook text covered only two of Tinbergen's questions (survival value and causation). The other two questions, evolution and ontogeny, were rarely described in the text. A similar trend was found in journal articles. Therefore, alignment is occurring between primary literature and education, but neither aligns with the established conceptual framework of the discipline. According to course descriptions, many instructors intend to use an integrated

  2. Suicide among animals: clues from folklore that may prevent suicidal behaviour in human beings.

    Science.gov (United States)

    Preti, Antonio

    2005-10-01

    Knowing the most likely reasons for suicide might increase the chances to identify the early signs of suicide. Folkloric tales on suicide among animals are a possible source of such information, since people probably explain animal suicide using the same reasons they would apply to their kin. Modern naturalistic studies ave found little evidence of self-harming conduct among nonhuman species. Nevertheless, mythological accounts often report suicidal behaviour among animals. Claudius Aelian's De natura animalium, a classic in its genre, written in the 2nd century AD, reports 21 cases of suicide among animals. In Aelian's tales, the severing of social ties emerges as an important motive for suicide, together with incest and rage caused by adultery. Paying attention to the mechanisms leading to suicide described in ancient mythology may help us understand unusual and uncommon motives for suicide and the reasons people feel suicidal.

  3. Myiasis in pet animals in British Columbia: The potential of forensic entomology for determining duration of possible neglect

    OpenAIRE

    2004-01-01

    Results of a survey of veterinarians in British Columbia included 25 past cases of myiasis and 10 active cases. Most respondents received at least 5 to 10 cases per year, with some as high as 30 per year. This study revealed some advantages and disadvantages of using forensic entomology in living animals.

  4. Animal behaviour shapes the ecological effects of ocean acidification and warming: moving from individual to community-level responses.

    Science.gov (United States)

    Nagelkerken, Ivan; Munday, Philip L

    2016-03-01

    Biological communities are shaped by complex interactions between organisms and their environment as well as interactions with other species. Humans are rapidly changing the marine environment through increasing greenhouse gas emissions, resulting in ocean warming and acidification. The first response by animals to environmental change is predominantly through modification of their behaviour, which in turn affects species interactions and ecological processes. Yet, many climate change studies ignore animal behaviour. Furthermore, our current knowledge of how global change alters animal behaviour is mostly restricted to single species, life phases and stressors, leading to an incomplete view of how coinciding climate stressors can affect the ecological interactions that structure biological communities. Here, we first review studies on the effects of warming and acidification on the behaviour of marine animals. We demonstrate how pervasive the effects of global change are on a wide range of critical behaviours that determine the persistence of species and their success in ecological communities. We then evaluate several approaches to studying the ecological effects of warming and acidification, and identify knowledge gaps that need to be filled, to better understand how global change will affect marine populations and communities through altered animal behaviours. Our review provides a synthesis of the far-reaching consequences that behavioural changes could have for marine ecosystems in a rapidly changing environment. Without considering the pervasive effects of climate change on animal behaviour we will limit our ability to forecast the impacts of ocean change and provide insights that can aid management strategies.

  5. Neglect and Self-Neglect

    Science.gov (United States)

    ... Paveza, G. Neglect in the elderly patient. (1998). Nursing Clinics of North America. 33(3), 457-467. Rathborn-McCuan, E., & Fabian, D.R. (Eds.). (1992). Self-neglecting elders: A clinical dilemma. Westport, CT: Auburn House Home | About NCPEA | Elder ...

  6. Enantiomeric behaviour of albendazole and fenbendazole sulfoxides in domestic animals: pharmacological implications.

    Science.gov (United States)

    Capece, Bettencourt P S; Virkel, Guillermo L; Lanusse, Carlos E

    2009-09-01

    Albendazole and fenbendazole are methylcarbamate benzimidazole anthelmintics extensively used to control gastrointestinal parasites in domestic animals. These parent compounds are metabolised to albendazole sulfoxide and fenbendazole sulfoxide (oxfendazole), respectively. Both sulfoxide derivatives are anthelmintically active and are manufactured for use in animals. They metabolites have an asymmetric centre on their chemical structures and two enantiomeric forms of each sulfoxide have been identified in plasma, tissues of parasite location and within target helminths. Both the flavin-monooxygenase and cytochrome P450 systems are involved in the enantioselective biotransformation of these anthelmintic compounds in ruminant species. A relevant progress on the understanding of the relationship among enantioselective metabolism and systemic availability of each enantiomeric form has been achieved. This article reviews the current knowledge on the pharmacological implications of the enantiomeric behaviour of albendazole sulfoxide and oxfendazole in domestic animals.

  7. Mechanistic models of animal migration behaviour--their diversity, structure and use.

    Science.gov (United States)

    Bauer, Silke; Klaassen, Marcel

    2013-05-01

    1. Migration is a widespread phenomenon in the animal kingdom, including many taxonomic groups and modes of locomotion. Developing an understanding of the proximate and ultimate causes for this behaviour not only addresses fundamental ecological questions but has relevance to many other fields, for example in relation to the spread of emerging zoonotic diseases, the proliferation of invasive species, aeronautical safety as well as the conservation of migrants. 2. Theoretical methods can make important contributions to our understanding of migration, by allowing us to integrate findings on this complex behaviour, identify caveats in our understanding and to guide future empirical research efforts. Various mechanistic models exist to date, but their applications seem to be scattered and far from evenly distributed across taxonomic units. 3. Therefore, we provide an overview of the major mechanistic modelling approaches used in the study of migration behaviour and characterize their fundamental features, assumptions and limitations and discuss their typical data requirements both for model parameterization and for scrutinizing model predictions. 4. Furthermore, we review 155 studies that have used mechanistic models to study animal migration and analyse them with regard to the approaches used and the focal species, and also explore their contribution to advancing current knowledge within six broad migration ecology research themes. 5. This identifies important gaps in our present knowledge, which should be tackled in future research using existing and to-be developed theoretical approaches.

  8. Optimized Hyper Beamforming of Linear Antenna Arrays Using Collective Animal Behaviour

    Directory of Open Access Journals (Sweden)

    Gopi Ram

    2013-01-01

    Full Text Available A novel optimization technique which is developed on mimicking the collective animal behaviour (CAB is applied for the optimal design of hyper beamforming of linear antenna arrays. Hyper beamforming is based on sum and difference beam patterns of the array, each raised to the power of a hyperbeam exponent parameter. The optimized hyperbeam is achieved by optimization of current excitation weights and uniform interelement spacing. As compared to conventional hyper beamforming of linear antenna array, real coded genetic algorithm (RGA, particle swarm optimization (PSO, and differential evolution (DE applied to the hyper beam of the same array can achieve reduction in sidelobe level (SLL and same or less first null beam width (FNBW, keeping the same value of hyperbeam exponent. Again, further reductions of sidelobe level (SLL and first null beam width (FNBW have been achieved by the proposed collective animal behaviour (CAB algorithm. CAB finds near global optimal solution unlike RGA, PSO, and DE in the present problem. The above comparative optimization is illustrated through 10-, 14-, and 20-element linear antenna arrays to establish the optimization efficacy of CAB.

  9. Optimized hyper beamforming of linear antenna arrays using collective animal behaviour.

    Science.gov (United States)

    Ram, Gopi; Mandal, Durbadal; Kar, Rajib; Ghoshal, Sakti Prasad

    2013-01-01

    A novel optimization technique which is developed on mimicking the collective animal behaviour (CAB) is applied for the optimal design of hyper beamforming of linear antenna arrays. Hyper beamforming is based on sum and difference beam patterns of the array, each raised to the power of a hyperbeam exponent parameter. The optimized hyperbeam is achieved by optimization of current excitation weights and uniform interelement spacing. As compared to conventional hyper beamforming of linear antenna array, real coded genetic algorithm (RGA), particle swarm optimization (PSO), and differential evolution (DE) applied to the hyper beam of the same array can achieve reduction in sidelobe level (SLL) and same or less first null beam width (FNBW), keeping the same value of hyperbeam exponent. Again, further reductions of sidelobe level (SLL) and first null beam width (FNBW) have been achieved by the proposed collective animal behaviour (CAB) algorithm. CAB finds near global optimal solution unlike RGA, PSO, and DE in the present problem. The above comparative optimization is illustrated through 10-, 14-, and 20-element linear antenna arrays to establish the optimization efficacy of CAB.

  10. Automated long-term tracking and social behavioural phenotyping of animal colonies within a semi-natural environment.

    Science.gov (United States)

    Weissbrod, Aharon; Shapiro, Alexander; Vasserman, Genadiy; Edry, Liat; Dayan, Molly; Yitzhaky, Assif; Hertzberg, Libi; Feinerman, Ofer; Kimchi, Tali

    2013-01-01

    Social behaviour has a key role in animal survival across species, ranging from insects to primates and humans. However, the biological mechanisms driving natural interactions between multiple animals, over long-term periods, are poorly studied and remain elusive. Rigorous and objective quantification of behavioural parameters within a group poses a major challenge as it requires simultaneous monitoring of the positions of several individuals and comprehensive consideration of many complex factors. Automatic tracking and phenotyping of interacting animals could thus overcome the limitations of manual tracking methods. Here we report a broadly applicable system that automatically tracks the locations of multiple, uniquely identified animals, such as mice, within a semi-natural setting. The system combines video and radio frequency identified tracking data to obtain detailed behavioural profiles of both individuals and groups. We demonstrate the usefulness of these data in characterizing individual phenotypes, interactions between pairs and the collective social organization of groups.

  11. Flow cytometric determination of osmotic behaviour of animal erythrocytes toward their engineering for drug delivery

    Directory of Open Access Journals (Sweden)

    Kostić Ivana T.

    2015-01-01

    Full Text Available Despite the fact that the methods based on the osmotic properties of the cells are the most widely used for loading of drugs in human and animal erythrocytes, data related to the osmotic properties of erythrocytes derived from animal blood are scarce. This work was performed with an aim to investigate the possibility of use the flow cytometry as a tool for determination the osmotic behaviour of porcine and bovine erythrocytes, and thus facilitate the engineering of erythrocytes from animal blood to be drug carriers. The method of flow cytometry successfully provided the information about bovine and porcine erythrocyte osmotic fragility, and made the initial steps in assessment of erythrocyte shape in a large number of erythrocytes. Although this method is not able to confirm the swelling of pig erythrocytes, it indicated to the differences in pig erythrocytes that had basic hematological parameters inside and outside the reference values. In order to apply/use the porcine and bovine erythrocytes as drug carriers, the method of flow cytometry, confirming the presence of osmotically different fractions of red blood cells, indicated that various amounts of the encapsulated drug in porcine and bovine erythrocytes can be expected.

  12. Global positioning system and associated technologies in animal behaviour and ecological research

    Science.gov (United States)

    Tomkiewicz, Stanley M.; Fuller, Mark R.; Kie, John G.; Bates, Kirk K.

    2010-01-01

    Biologists can equip animals with global positioning system (GPS) technology to obtain accurate (less than or equal to 30 m) locations that can be combined with sensor data to study animal behaviour and ecology. We provide the background of GPS techniques that have been used to gather data for wildlife studies. We review how GPS has been integrated into functional systems with data storage, data transfer, power supplies, packaging and sensor technologies to collect temperature, activity, proximity and mortality data from terrestrial species and birds. GPS 'rapid fixing' technologies combined with sensors provide location, dive frequency and duration profiles, and underwater acoustic information for the study of marine species. We examine how these rapid fixing technologies may be applied to terrestrial and avian applications. We discuss positional data quality and the capability for high-frequency sampling associated with GPS locations. We present alternatives for storing and retrieving data by using dataloggers (biologging), radio-frequency download systems (e.g. very high frequency, spread spectrum), integration of GPS with other satellite systems (e.g. Argos, Globalstar) and potential new data recovery technologies (e.g. network nodes). GPS is one component among many rapidly evolving technologies. Therefore, we recommend that users and suppliers interact to ensure the availability of appropriate equipment to meet animal research objectives.

  13. Global positioning system and associated technologies in animal behaviour and ecological research.

    Science.gov (United States)

    Tomkiewicz, Stanley M; Fuller, Mark R; Kie, John G; Bates, Kirk K

    2010-07-27

    Biologists can equip animals with global positioning system (GPS) technology to obtain accurate (less than or equal to 30 m) locations that can be combined with sensor data to study animal behaviour and ecology. We provide the background of GPS techniques that have been used to gather data for wildlife studies. We review how GPS has been integrated into functional systems with data storage, data transfer, power supplies, packaging and sensor technologies to collect temperature, activity, proximity and mortality data from terrestrial species and birds. GPS 'rapid fixing' technologies combined with sensors provide location, dive frequency and duration profiles, and underwater acoustic information for the study of marine species. We examine how these rapid fixing technologies may be applied to terrestrial and avian applications. We discuss positional data quality and the capability for high-frequency sampling associated with GPS locations. We present alternatives for storing and retrieving data by using dataloggers (biologging), radio-frequency download systems (e.g. very high frequency, spread spectrum), integration of GPS with other satellite systems (e.g. Argos, Globalstar) and potential new data recovery technologies (e.g. network nodes). GPS is one component among many rapidly evolving technologies. Therefore, we recommend that users and suppliers interact to ensure the availability of appropriate equipment to meet animal research objectives.

  14. Neglected bacterial zoonoses.

    Science.gov (United States)

    Chikeka, I; Dumler, J S

    2015-05-01

    Bacterial zoonoses comprise a group of diseases in humans or animals acquired by direct contact with or by oral consumption of contaminated animal materials, or via arthropod vectors. Among neglected infections, bacterial zoonoses are among the most neglected given emerging data on incidence and prevalence as causes of acute febrile illness, even in areas where recognized neglected tropical diseases occur frequently. Although many other bacterial infections could also be considered in this neglected category, five distinct infections stand out because they are globally distributed, are acute febrile diseases, have high rates of morbidity and case fatality, and are reported as commonly as malaria, typhoid or dengue virus infections in carefully designed studies in which broad-spectrum diagnoses are actively sought. This review will focus attention on leptospirosis, relapsing fever borreliosis and rickettsioses, including scrub typhus, murine typhus and spotted fever group rickettsiosis. Of greatest interest is the lack of distinguishing clinical features among these infections when in humans, which confounds diagnosis where laboratory confirmation is lacking, and in regions where clinical diagnosis is often attributed to one of several perceived more common threats. As diseases such as malaria come under improved control, the real impact of these common and under-recognized infections will become evident, as will the requirement for the strategies and allocation of resources for their control.

  15. Peripheral and central neuroinflammatory changes and pain behaviours in an animal model of multiple sclerosis

    Directory of Open Access Journals (Sweden)

    Samuel Shaw Duffy

    2016-09-01

    Full Text Available Pain is a widespread and debilitating symptom of multiple sclerosis (MS, a chronic inflammatory demyelinating disease of the central nervous system. Although central neuroinflammation and demyelination have been implicated in MS-related pain, the contribution of peripheral and central mechanisms during different phases of the disease remains unclear. In this study, we used the animal model experimental autoimmune encephalomyelitis (EAE to examine both stimulus-evoked and spontaneous pain behaviours, and neuroinflammatory changes, over the course of chronic disease. We found that mechanical allodynia of the hind paw preceded the onset of clinical EAE, but was unmeasurable at clinical peak. This mechanical hypersensitivity coincided with increased microglial activation confined to the dorsal horn of the spinal cord. The development of facial mechanical allodynia also emerged in pre-clinical EAE, persisted at the clinical peak, and corresponded with pathology of the peripheral trigeminal afferent pathway. This included T cell infiltration, which arose prior to overt central lesion formation, and specific damage to myelinated neurons during the clinical peak. Measurement of spontaneous pain using the mouse grimace scale, a facial expression-based coding system, showed increased facial grimacing in mice with EAE during clinical disease. This was associated with multiple peripheral and central neuroinflammatory changes including a decrease in myelinating oligodendrocytes, increased T cell infiltration and macrophage/microglia and astrocyte activation. Overall, these findings suggest that different pathological mechanisms may underlie stimulus-evoked and spontaneous pain in EAE, and that these behaviours predominate in unique stages of the disease.

  16. Can laboratory animals violate behavioural norms? Towards a preclinical model of conduct disorder.

    Science.gov (United States)

    Macrì, Simone; Zoratto, Francesca; Chiarotti, Flavia; Laviola, Giovanni

    2017-02-03

    Conduct disorder (CD), a disturbance characterised by excess rates of aggression - often associated with callousness, lack of empathy and shallow/deficient affect - is extremely prevalent (2-10%) in the juvenile population. CD symptoms are quantitative rather than qualitative in nature whereby, rather than exhibiting abnormal behaviours, CD patients indulge in normal behaviours at abnormal rates. Although genetic and environmental factors contribute to CD aetiology, their precise contribution is yet to be determined. Experimental animal models may aid discriminating genetic vs. environmental effects and designing innovative therapeutic approaches. Here we discuss a theoretical framework potentially favouring the design of experimental models of CD. We suggest that the latter shall recapitulate the "norm violation" typical of the human disorder across the core domains involved in CD: aggression, callousness, empathy and emotionality. We first review how these domains have been operationalised in preclinical models; we then suggest that these experimental paradigms shall be combined with appropriate statistical tools to identify a subset of individuals consistently characterised by abnormal values in CD-relevant phenotypes.

  17. The Use of Acceleration to Code for Animal Behaviours; A Case Study in Free-Ranging Eurasian Beavers Castor fiber.

    Directory of Open Access Journals (Sweden)

    Patricia M Graf

    Full Text Available Recent technological innovations have led to the development of miniature, accelerometer-containing electronic loggers which can be attached to free-living animals. Accelerometers provide information on both body posture and dynamism which can be used as descriptors to define behaviour. We deployed tri-axial accelerometer loggers on 12 free-ranging Eurasian beavers Castor fiber in the county of Telemark, Norway, and on four captive beavers (two Eurasian beavers and two North American beavers C. canadensis to corroborate acceleration signals with observed behaviours. By using random forests for classifying behavioural patterns of beavers from accelerometry data, we were able to distinguish seven behaviours; standing, walking, swimming, feeding, grooming, diving and sleeping. We show how to apply the use of acceleration to determine behaviour, and emphasise the ease with which this non-invasive method can be implemented. Furthermore, we discuss the strengths and weaknesses of this, and the implementation of accelerometry on animals, illustrating limitations, suggestions and solutions. Ultimately, this approach may also serve as a template facilitating studies on other animals with similar locomotor modes and deliver new insights into hitherto unknown aspects of behavioural ecology.

  18. Neglected and endemic zoonoses

    OpenAIRE

    2009-01-01

    Endemic zoonoses are found throughout the developing world, wherever people live in close proximity to their animals, affecting not only the health of poor people but often also their livelihoods through the health of their livestock. Unlike newly emerging zoonoses that attract the attention of the developed world, these endemic zoonoses are by comparison neglected. This is, in part, a consequence of under-reporting, resulting in underestimation of their global burden, which in turn artificia...

  19. A less stressful animal model: a conditioned avoidance behaviour task for guineapigs.

    Science.gov (United States)

    Agterberg, Martijn J H; van den Broek, Marloes; Philippens, Ingrid H C H M

    2010-07-01

    In the conventional shuttle box, animals are trained to avoid electric foot-shocks. As a consequence of these stress-inducing foot-shocks the animals become anxious and are difficult to train. The aim of the present study was to avoid the stress-inducing foot-shocks and to develop a fast and reliable conditioned avoidance behaviour task for guineapigs. We examined whether narrowband noises at four different sound levels above hearing threshold could be used as conditioned stimulus (CS). The unconditioned stimulus (UCS) was a stream of air, which was used instead of the conventionally used electric foot-shocks. The animals were initially trained with a CS of 78 dB sound pressure level (SPL). In this initial training, guineapigs learned to detect a narrowband noise of 78 dB SPL. Interestingly, during the first additional training session in which three other sound levels were applied, guineapigs did not immediately generalize the learned response at 78 dB SPL to lower sound levels of 58 and 68 dB SPL. However, in this session a noise level of 88 dB SPL led immediately to a high level of responses. The response latency decreased with increasing sound level, from approximately 7 s at 58 dB SPL to approximately 3 s at 88 dB SPL. The escape latency during the UCS was approximately 0.6 s. The present results demonstrate that after reducing the level of stress guineapigs can acquire a response in only a few sessions and furthermore, although the guineapigs were less anxious, training at sound levels of 78 and 88 dB SPL was influenced by an aversive reaction by the guineapig. The results indicate that this aversive reaction of the guineapig is crucial for the training.

  20. Effects of adverse early-life events on aggression and anti-social behaviours in animals and humans.

    Science.gov (United States)

    Haller, J; Harold, G; Sandi, C; Neumann, I D

    2014-10-01

    We review the impact of early adversities on the development of violence and antisocial behaviour in humans, and present three aetiological animal models of escalated rodent aggression, each disentangling the consequences of one particular adverse early-life factor. A review of the human data, as well as those obtained with the animal models of repeated maternal separation, post-weaning social isolation and peripubertal stress, clearly shows that adverse developmental conditions strongly affect aggressive behaviour displayed in adulthood, the emotional responses to social challenges and the neuronal mechanisms activated by conflict. Although similarities between models are evident, important differences were also noted, demonstrating that the behavioural, emotional and neuronal consequences of early adversities are to a large extent dependent on aetiological factors. These findings support recent theories on human aggression, which suggest that particular developmental trajectories lead to specific forms of aggressive behaviour and brain dysfunctions. However, dissecting the roles of particular aetiological factors in humans is difficult because these occur in various combinations; in addition, the neuroscientific tools employed in humans still lack the depth of analysis of those used in animal research. We suggest that the analytical approach of the rodent models presented here may be successfully used to complement human findings and to develop integrative models of the complex relationship between early adversity, brain development and aggressive behaviour.

  1. A robust animal model of state anxiety : fear-potentiated behaviour in the elevated plus-maze

    NARCIS (Netherlands)

    Korte, SM; De Boer, SF

    2003-01-01

    Fear (i.e., decreased percentage time spent on open-arm exploration) in the elevated plus-maze can be potentiated by prior inescapable stressor exposure, but not by escapable stress. The use of fear-potentiated plus-maze behaviour has several advantages as compared to more traditional animal models

  2. Hormonal and behavioural abnormalities induced by stress in utero: an animal model for depression.

    Science.gov (United States)

    Maccari, S; Darnaudery, M; Van Reeth, O

    2001-09-01

    Prenatal stress in rats can exert profound influence on the off spring's development, inducing abnormalities such as increased "anxiety", "emotionality" or "depression-like" behaviours.Prenatal stress has long-term effects on the development of the hypothalamo-pituitary-adrenal(HPA) axis and forebrain cholinergic systems. These long-term neuroendocrinological effects are mediated, at least in part, by stress-induced maternal corticosterone increase during pregnancy and stress-induced maternal anxiety during the postnatal period. We have shown a significant phase advance in the circadian rhythms of corticosterone secretion and locomotor activity in prenatally-stressed (PNS) rats. When subjected to an abrupt shift in the light-dark(LD) cycle, PNS rats resynchronized their activity rhythm more slowly than control rats. In view of the data suggesting abnormalities in the circadian timing system in these animals, we have investigated the effects of prenatal stress on the sleep-wake cycle in adult male rats. PNS rats exhibited various changes in sleep-wake parameters, including a dramatic increase in the amount of paradoxical sleep. Taken together, our results indicate that prenatal stress can induce increased responses to stress and abnormal circadian rhythms and sleep in adult rats.Various clinical observations in humans suggest a possible pathophysiological link between depression and disturbances in circadian rhythmicity. Circadian abnormalities in depression can be related to those found in PNS rats. Interestingly, we have recently shown that the increased immobility in the forced swimming test observed in PNS rats can be corrected by chronic treatment with the antidepressant tianeptine, or with melatonin or S23478, a melatonin agonist. Those results reinforce the idea of the usefulness of PNS rats as an appropriate animal model to study human depression and support a new antidepressant-like effect of melatonin and the melatonin agonist S23478.

  3. Using photographs to study animal social cognition and behaviour: Do capuchins' responses to photos reflect reality?

    Science.gov (United States)

    Morton, F Blake; Brosnan, Sarah F; Prétôt, Laurent; Buchanan-Smith, Hannah M; O'Sullivan, Eoin; Stocker, Martina; D'Mello, Daniel; Wilson, Vanessa A D

    2016-03-01

    Behavioural responses to photos are often used to infer what animals understand about their social environment, but are rarely validated against the same stimuli in real life. If subjects' responses to photos do not reflect responses to the same live stimuli, it is difficult to conclude what happens in reality based on photo responses alone. We compared capuchins' responses to photos versus live stimuli in an identical scenario within research cubicles. Subjects had the opportunity to approach food placed in front of an alpha group member and, in a separate condition, photos depicting the same individual. Subjects' latencies to approach food when placed in front of the real alpha negatively correlated with time subjects spent in close proximity to the alpha in their main enclosure. We therefore predicted subjects' latencies to approach food in the presence of photos would positively correlate with their latencies to approach food in the presence of the real alpha inside the cubicles, but negatively correlate with time they spent in proximity to the alpha in their enclosure. Neither prediction was supported. While not necessarily surprising, we explain why these results should be an important reminder that care is needed when interpreting results from photo studies.

  4. Genetics of animal temperament: aggressive behaviour at mixing is genetically associated with the response to handling in pigs.

    Science.gov (United States)

    D'Eath, R B; Roehe, R; Turner, S P; Ison, S H; Farish, M; Jack, M C; Lawrence, A B

    2009-11-01

    described by the concept of animal temperament (also known as coping styles, personality or behavioural syndromes), but this has rarely been demonstrated at the genetic level in farm animals. These findings may have practical implications for the development of breeding programmes aimed at altering animal temperament. Breeding to reduce aggression could result in some reduction in activity at weighing. This would have consequences for animal production, because pigs which are inactive at weighing take longer to move into and out of the weigh crate, and perhaps also for animal welfare.

  5. Combined production of free-range pigs and energy crops – animal behaviour and crop damages

    DEFF Research Database (Denmark)

    Horsted, Klaus; Kongsted, Anne Grete; Jørgensen, Uffe

    2012-01-01

    to six paddocks, which, in turn, were divided into high and low-density paddocks of 700 m2 and 2200 m2, i.e. 117 and 367 m2 per pig respectively. All paddocks were divided into seven different zones representing two zones with willow, two with grass, and one each with Miscanthus, cut Miscanthus (stubs......) and a feeding area. Overall, ‘resting’ was the most frequent behaviour of all observations followed by ‘rooting’ with 54.4% and 19.3% of all behavioural observations, respectively. There were no main effects of stocking density for any of the behavioural elements. The excretory behaviour was significantly more...

  6. Animal spirits, liquidity-preference and Keynesian behavioural macroeconomics: An intertemporal framework

    OpenAIRE

    Koutsobinas, Theodore

    2011-01-01

    Abstract The utilization of a real-interest rate rule in Romer’s new-Keynesian IS-MP approach, which is consistent with new synthesis intertemporal baseline macroeconomic models, provides a contemporary alternative to the standard old-Keynesian IS-LM model and moves back the emphasis on general accounts of the macroeconomic process. Despite its merits, the IS-MP approach neglects completely the influence of the liquidity-preference typically associated in pure Keynes framework with the imp...

  7. Neural coding of basic reward terms of animal learning theory, game theory, microeconomics and behavioural ecology.

    Science.gov (United States)

    Schultz, Wolfram

    2004-04-01

    Neurons in a small number of brain structures detect rewards and reward-predicting stimuli and are active during the expectation of predictable food and liquid rewards. These neurons code the reward information according to basic terms of various behavioural theories that seek to explain reward-directed learning, approach behaviour and decision-making. The involved brain structures include groups of dopamine neurons, the striatum including the nucleus accumbens, the orbitofrontal cortex and the amygdala. The reward information is fed to brain structures involved in decision-making and organisation of behaviour, such as the dorsolateral prefrontal cortex and possibly the parietal cortex. The neural coding of basic reward terms derived from formal theories puts the neurophysiological investigation of reward mechanisms on firm conceptual grounds and provides neural correlates for the function of rewards in learning, approach behaviour and decision-making.

  8. Modulation of early stress-induced neurobiological changes: a review of behavioural and pharmacological interventions in animal models.

    Science.gov (United States)

    Harrison, E L; Baune, B T

    2014-05-13

    Childhood adversity alters the predisposition to psychiatric disorders later in life. Those with psychiatric conditions and a history of early adversity exhibit a higher incidence of treatment resistance compared with individuals with no such history. Modulation of the influence early stress exerts over neurobiology may help to prevent the development of psychiatric disorders in some cases, while attenuating the extent of treatment resistance in those with established psychiatric disorders. This review aims to critically evaluate the ability of behavioural, environmental and pharmacologic interventions to modulate neurobiological changes induced by early stress in animal models. Databases were systematically searched to locate literature relevant to this review. Early adversity was defined as stress that resulted from manipulation of the mother-infant relationship. Analysis was restricted to animal models to enable characterisation of how a given intervention altered specific neurobiological changes induced by early stress. A wide variety of changes in neurobiology due to early stress are amenable to intervention. Behavioural interventions in childhood, exercise in adolescence and administration of epigenetic-modifying drugs throughout life appear to best modulate cellar and behavioural alterations induced by childhood adversity. Other pharmacotherapies, such as endocannabinoid system modulators, anti-inflammatories and antidepressants can also influence these neurobiological and behavioural changes that result from early stress, although findings are less consistent at present and require further investigation. Further work is required to examine the influence that behavioural interventions, exercise and epigenetic-modifying drugs exert over alterations that occur following childhood stress in human studies, before possible translational into clinical practice is possible.

  9. How Growing Complexity of Consumer Choices and Drivers of Consumption Behaviour Affect Demand for Animal Source Foods.

    Science.gov (United States)

    Perry, B D; Grace, D C

    2015-12-01

    Many societies are spoiled for choice when they purchase meat and other livestock products, and around the globe food choice has grown dramatically in the last two decades. What is more, besides the cost and obvious health concerns influencing commodity section, an increasing proportion of choices is made to contribute to the achievement of certain ideals, such as natural resource management, climate change mitigation, animal welfare concerns and personal lifestyle. At the same time, human health considerations are becoming more important for consumption choices as richer societies, and increasingly the urban poor in low- and middle-income countries, face an unprecedented epidemic of over-consumption and associated diet-related non-communicable diseases. Animal source foods are considered significant contributors to this trend. This paper reviews this complicated arena, and explores the range of considerations that influence consumers' preferences for meat and other animal source foods. This paper also argues that deeper drivers of consumption behaviour of many foods may act in opposition to the articulated preferences for choices around animal source food consumption. We review how the returns to different causes are being valued, how emerging metrics are helping to manage and influence consumption behaviours, and draw conclusions regarding options which influence food choice.

  10. Does the Animal Fun program improve social-emotional and behavioural outcomes in children aged 4-6 years?

    Science.gov (United States)

    Piek, Jan P; Kane, Robert; Rigoli, Daniela; McLaren, Sue; Roberts, Clare M; Rooney, Rosanna; Jensen, Lynn; Dender, Alma; Packer, Tanya; Straker, Leon

    2015-10-01

    Animal Fun was designed to enhance motor and social development in young children. Its efficacy in improving motor skills was presented previously using a randomised controlled trial and a multivariate nested cohort design. Based on the Environmental Stress Hypothesis, it was argued that the program would also result in positive mental health outcomes, investigated in the current study. Pre-intervention scores were recorded for 511 children aged 4.83-6.17 years (M=5.42, SD=.30). Intervention and control groups were compared 6 months following intervention, and again in their first school year. Changes in teacher-rated prosocial behaviour and total difficulties were assessed using the Strengths and Difficulties Questionnaire, and data analysed using Generalised Linear Mixed Models. There was a significant improvement in prosocial behaviour of children in the intervention group six months after initial testing, which remained at 18-month follow-up. Total difficulties decreased at 6 months for the intervention group, with no change at 18 months. This effect was present only for the hyperactivity/inattention subscale. The only significant change for the control group was an increase in hyperactivity/inattention scores from pre-intervention to 18-month follow-up. The Animal Fun program appears to be effective in improving social and behavioural outcomes.

  11. A new behavioural apparatus to reduce animal numbers in multiple types of spontaneous object recognition paradigms in rats.

    Science.gov (United States)

    Ameen-Ali, K E; Eacott, M J; Easton, A

    2012-10-15

    Standard object recognition procedures assess animals' memory through their spontaneous exploration of novel objects or novel configurations of objects with other aspects of their environment. Such tasks are widely used in memory research, but also in pharmaceutical companies screening new drug treatments. However, behaviour in these tasks may be driven by influences other than novelty such as stress from handling which can subsequently influence performance. This extra-experimental variance means that large numbers of animals are required to maintain power. In addition, accumulation of data is time consuming as animals typically perform only one trial per day. The present study aimed to explore how effectively recognition memory could be tested with a new continual trials apparatus which allows for multiple trials within a session and reduced handling stress through combining features of delayed nonmatching-to-sample and spontaneous object recognition tasks. In this apparatus Lister hooded rats displayed performance significantly above chance levels in object recognition tasks (Experiments 1 and 2) and in tasks of object-location (Experiment 3) and object-in-context memory (Experiment 4) with data from only five animals or fewer per experimental group. The findings indicated that the results were comparable to those of previous reports in the literature and maintained statistical power whilst using less than a third of the number of animals typically used in spontaneous recognition paradigms. Overall, the results highlight the potential benefit of the continual trials apparatus to reduce the number of animals used in recognition memory tasks.

  12. Self-Injurious Behaviour: Limbic Dysregulation and Stress Effects in an Animal Model

    Science.gov (United States)

    Muehlmann, A. M.; Kies, S. D.; Turner, C. A.; Wolfman, S.; Lewis, M. H.; Devine, D. P.

    2012-01-01

    Background: Self-injurious behaviour (SIB) is prevalent in neurodevelopmental disorders, but its expression is highly variable within, and between diagnostic categories. This raises questions about the factors that contribute to aetiology and expression of SIB. Expression of SIB is generally described in relation to social reinforcement. However,…

  13. Dynamic performances of cattle transporting vehicle on Scandinavian roads and behavioural response of animals.

    Science.gov (United States)

    Wikner, I; Gebresenbet, G; Tolo, E

    2003-03-01

    Driving performance, air quality in the vehicle, and handling during loading and unloading are the main factors, which could affect animal welfare. During transport of animals from farms to abattoirs, animals on the vehicle are subjected to vibrations in all directions. Performances of a typical vehicle for cattle transport have been studied under field commercial conditions. During the experiment, tri-axial vibrations on the vehicle, as well as velocity, slope and position were measured. The animals were video recorded for behavioral analyses. Geographical positions, speed and slope of roads were recorded using, GPS. Measurements were made with and without animals on the vehicle. The roads in the region are narrow almost everywhere, but rather plane and of good quality. Three road types were identified: straight and plain, curvy and graveled roads. Events such as sudden stops and curves were observed and noted. Vibration levels in tri-axial directions have been measured and analysed for different speeds and road types both when the vehicle was fully loaded and unloaded. There is a significant difference between the performances of the vehicle when loaded and unloaded. Very high vibrations values have been noted during the empty driving and these values were reduced by up to 9 times when the vehicle was loaded. Less vibrations amplitudes were observed and animals were calmer on ferry transport than on road transport. It has also been noted that animals prefer to stand perpendicular to the direction of vehicle's motion during transport.

  14. Liver irradiation causes distal bystander effects in the rat brain and affects animal behaviour.

    Science.gov (United States)

    Kovalchuk, Anna; Mychasiuk, Richelle; Muhammad, Arif; Hossain, Shakhawat; Ilnytskyy, Slava; Ghose, Abhijit; Kirkby, Charles; Ghasroddashti, Esmaeel; Kovalchuk, Olga; Kolb, Bryan

    2016-01-26

    Radiation therapy can not only produce effects on targeted organs, but can also influence shielded bystander organs, such as the brain in targeted liver irradiation. The brain is sensitive to radiation exposure, and irradiation causes significant neuro-cognitive deficits, including deficits in attention, concentration, memory, and executive and visuospatial functions. The mechanisms of their occurrence are not understood, although they may be related to the bystander effects.We analyzed the induction, mechanisms, and behavioural repercussions of bystander effects in the brain upon liver irradiation in a well-established rat model.Here, we show for the first time that bystander effects occur in the prefrontal cortex and hippocampus regions upon liver irradiation, where they manifest as altered gene expression and somewhat increased levels of γH2AX. We also report that bystander effects in the brain are associated with neuroanatomical and behavioural changes, and are more pronounced in females than in males.

  15. Social behaviour of dogs encountering AIBO, an animal-like robot in a neutral and in a feeding situation.

    Science.gov (United States)

    Kubinyi, Eniko; Miklósi, Adám; Kaplan, Frédéric; Gácsi, Márta; Topál, József; Csányi, Vilmos

    2004-03-31

    The use of animal-like autonomous robots might offer new possibilities in the study of animal interactions, if the subject recognises it as a social partner. In this paper we investigate whether AIBO, a dog-like robot of the Sony Corp. can be used for this purpose. Twenty-four adult and sixteen 4-5 months old pet dogs were tested in two situations where subjects encountered one of four different test-partners: (1) a remote controlled car; (2) an AIBO robot; (3) AIBO with a puppy-scented furry cover; and (4) a 2-month-old puppy. In the neutral situation the dog could interact freely with one of the partners for 1 min in a closed arena in the presence of its owner. In the feeding situation the encounters were started while the dog was eating food. Our results show that age and context influence the social behaviour of dogs. Further, we have found that although both age groups differentiated the living and non-living test-partners for some extent, the furry AIBO evoked significantly increased responses in comparison to the car. These experiments show the first steps towards the application of robots in behavioural studies, notwithstanding that at present AIBO's limited ability to move constrains its effectiveness as social partner for dogs.

  16. Recent advances in bio-logging science: Technologies and methods for understanding animal behaviour and physiology and their environments

    Science.gov (United States)

    Evans, K.; Lea, M.-A.; Patterson, T. A.

    2013-04-01

    The deployment of an ever-evolving array of animal-borne telemetry and data logging devices is rapidly increasing our understanding of the movement, behaviour and physiology of a variety species and the complex, and often highly dynamic, environments they use and respond to. The rapid rate at which new technologies, improvements to current technologies and new analytical techniques are being developed has meant that movements, behaviour and physiological processes are being quantified at finer spatial and temporal scales than ever before. The Fourth International Symposium on Bio-logging Science, held on 14-18 March in Hobart, Australia, brought together scientists across multiple disciplines to discuss the latest innovations in technology, applications and analytical techniques in bio-logging science, building on research presented at three previous conferences. Here we present an update on the state of bio-logging research and provide some views on the future of this field of research. Papers were grouped into five theme areas: (i) Southern Ocean ecosystems; (ii) fishery and biodiversity management applications; (iii) from individuals to populations—inferences of population dynamics from individuals; (iv) conservation biology and (v) habitat modelling. Papers reflected wider uptake of newer technologies, with a greater proportion of studies utilising accelerometry and incorporating advances in statistical modelling of behaviour and habitats, especially via state space modelling methods. Environmental data collected by tags at increasing accuracies are now having wider application beyond the bio-logging community, providing important oceanographic data from regions difficult to sample using traditional methodologies. Partnerships between multiple organisations are also now enabling regional assessments of species movements, behaviour and physiology at population scales and will continue to be important for applying bio-logging technologies to species

  17. Love thy neighbour: automatic animal behavioural classification of acceleration data using the K-nearest neighbour algorithm.

    Directory of Open Access Journals (Sweden)

    Owen R Bidder

    Full Text Available Researchers hoping to elucidate the behaviour of species that aren't readily observed are able to do so using biotelemetry methods. Accelerometers in particular are proving particularly effective and have been used on terrestrial, aquatic and volant species with success. In the past, behavioural modes were detected in accelerometer data through manual inspection, but with developments in technology, modern accelerometers now record at frequencies that make this impractical. In light of this, some researchers have suggested the use of various machine learning approaches as a means to classify accelerometer data automatically. We feel uptake of this approach by the scientific community is inhibited for two reasons; 1 Most machine learning algorithms require selection of summary statistics which obscure the decision mechanisms by which classifications are arrived, and 2 they are difficult to implement without appreciable computational skill. We present a method which allows researchers to classify accelerometer data into behavioural classes automatically using a primitive machine learning algorithm, k-nearest neighbour (KNN. Raw acceleration data may be used in KNN without selection of summary statistics, and it is easily implemented using the freeware program R. The method is evaluated by detecting 5 behavioural modes in 8 species, with examples of quadrupedal, bipedal and volant species. Accuracy and Precision were found to be comparable with other, more complex methods. In order to assist in the application of this method, the script required to run KNN analysis in R is provided. We envisage that the KNN method may be coupled with methods for investigating animal position, such as GPS telemetry or dead-reckoning, in order to implement an integrated approach to movement ecology research.

  18. Man, animal or both? Problems in the interpretation of early symbolic behaviour

    Directory of Open Access Journals (Sweden)

    Simona Petru

    2012-12-01

    Full Text Available The interpretation of the first symbolic behaviour is difficult, because our Western mind restricts us. It is hard, if not impossible, to understand the way ancient people perceived the world. The Palaeolithic was the period when the modern human mind had just emerged, and people understood time and the surrounding environment differently. With the appearance of the modern mind and the evolution of new perceptions of time, rituals and funerals emerged. Early therianthropes might be a reflection of this evolution of the human mind.

  19. Neglected and endemic zoonoses.

    Science.gov (United States)

    Maudlin, Ian; Eisler, Mark Charles; Welburn, Susan Christina

    2009-09-27

    Endemic zoonoses are found throughout the developing world, wherever people live in close proximity to their animals, affecting not only the health of poor people but often also their livelihoods through the health of their livestock. Unlike newly emerging zoonoses that attract the attention of the developed world, these endemic zoonoses are by comparison neglected. This is, in part, a consequence of under-reporting, resulting in underestimation of their global burden, which in turn artificially downgrades their importance in the eyes of administrators and funding agencies. The development of cheap and effective vaccines is no guarantee that these endemic diseases will be eliminated in the near future. However, simply increasing awareness about their causes and how they may be prevented-often with very simple technologies-could reduce the incidence of many endemic zoonoses. Sustainable control of zoonoses is reliant on surveillance, but, as with other public-sector animal health services, this is rarely implemented in the developing world, not least because of the lack of sufficiently cheap diagnostics. Public-private partnerships have already provided advocacy for human disease control and could be equally effective in addressing endemic zoonoses.

  20. Behavioural defences in animals against pathogens and parasites: parallels with the pillars of medicine in humans

    OpenAIRE

    2011-01-01

    No other theme in animal biology seems to be more central than the concept of employing strategies to survive and successfully reproduce. In nature, controlling or avoiding pathogens and parasites is an essential fitness strategy because of the ever-present disease-causing organisms. The disease-control strategies discussed here are: physical avoidance and removal of pathogens and parasites; quarantine or peripheralization of conspecifics that could be carrying potential pathogens; herbal med...

  1. Animals

    Energy Technology Data Exchange (ETDEWEB)

    Skuterud, L.; Strand, P. [Norwegian Radiation Protection Authority (Norway); Howard, B.J. [Inst. of Terrestrial Ecology (United Kingdom)

    1997-10-01

    The radionuclides of most concern with respect to contamination of animals after a nuclear accident are radioiodine, radiocaesium and radiostrontium (ICRP 30, 1979). Of the other significant anthropogenic radionuclides likely to be released in most accidents, only small proportions of that ingested will be absorbed in an animals gut, and the main animal products, milk and meat, will not normally be contaminated to a significant extent. Animal products will mostly be contaminated as a result of ingestion of contaminated feed and possibly, but to a much lesser extent, from inhalation (for radioiodine only). Direct external contamination of animals is of little or no consequence in human food production. Radioiodine and radiostrontium are important with respect to contamination of milk; radiocaesium contaminates both milk and meat. The physical and chemical form of a radionuclide can influence its absorption in the animal gut. For example, following the Chernobyl accident radiocaesium incorporated into vegetation by root uptake was more readily absorbed than that associated with the original deposit. The transfer of radiocaesium and radiostrontium to animals will be presented both as transfer coefficients and aggregated transfer coefficients. For most animal meat products, only radiocaesium is important as other radionuclides do not significantly contaminate muscle. Farm animal products are the most important foodstuff determining radiocaesium intake by the average consumer in the Nordic countries. The major potential source of radioiodine and radiostrontium to humans is milk and milk products. Of the different species, the smaller animals have the highest transfer of radiocaesium from fodder to meat and milk. (EG). 68 refs.

  2. Behavioural effects of near-term acute fetal hypoxia in a small precocial animal, the spiny mouse (Acomys cahirinus).

    Science.gov (United States)

    Ireland, Zoe; Dickinson, Hayley; Fleiss, Bobbi; Hutton, Lisa C; Walker, David W

    2010-01-01

    We have previously developed a model of near-term intra-uterine hypoxia producing significant neonatal mortality (37%) in a small laboratory animal - the spiny mouse - which has precocial offspring at birth. The aim of the present study was to determine if this insult resulted in the appearance of behavioural abnormalities in those offspring which survived the hypoxic delivery. Behavioural tests assessed gait (using footprint patterns), motor coordination and balance on an accelerating rotarod, and spontaneous locomotion and exploration in an open field. We found that the near-term acute hypoxic episode produced a mild neurological deficit in the early postnatal period. In comparison to vaginally delivered controls, hypoxia pups were able to remain on the accelerating rotarod for significantly shorter durations on postnatal days 1-2, and in the open field they travelled significantly shorter distances, jumped less, and spent a greater percentage of time stationary on postnatal days 5 and 15. No changes were observed in gait. Unlike some rodent models of cerebral hypoxia-ischaemia, macroscopic examination of the brain on postnatal day 5 showed no gross cystic lesions, oedema or infarct. Future studies should be directed at identifying hypoxia-induced alterations in the function of specific brain regions, and assessing if maternal administration of neuroprotective agents can prevent against hypoxia-induced neurological deficits and brain damage that occur at birth.

  3. Perfluoroalkylated substances in edible livers of farm animals, including depuration behaviour in young sheep fed with contaminated grass.

    Science.gov (United States)

    Zafeiraki, Effrosyni; Vassiliadou, Irene; Costopoulou, Danae; Leondiadis, Leondios; Schafft, Helmut A; Hoogenboom, Ron L A P; van Leeuwen, Stefan P J

    2016-08-01

    Perfluoroalkylated substances (PFASs) present a potential health risk for consumers. In animals these compounds are known to accumulate in livers. In order to determine potential PFASs contamination in commercially available livers, samples from farmed sheep, horses, cows, pigs and chicken were collected from the Dutch market. PFOS was the only detectable PFAS and its concentration was higher in free ranging animals like cows and sheep. The detected levels of PFOS in the liver samples were very low (up to 4.5 ng g(-1) ww). To further study the kinetic behaviour in foraging animals, samples from a study in which sheep were fed with grass obtained from a river floodplain, were examined. PFOS was the only detectable PFAS in the contaminated grass pellets, showing a level of about 0.5 μg kg(-1). Young blackhead sheep were fed with either clean or contaminated grass for a period up to 112 days. A time-dependent increase in liver PFOS concentrations was observed from 2.4 to 10.9 ng g(-1) ww after 8 and 112 days respectively. A time-dependent depuration was observed in livers of animals switched to clean grass after 56 days of exposure, from 9.2 to 4.7 ng g(-1) ww after 64 and 112 days respectively. The percentage of PFOS ingested from the grass and retained in the liver was estimated to be 12% at day 56, and decreased gradually to 6% after 56 days on clean grass, showing that the decrease in levels is not only caused by an increase in liver weight. Levels detected in commercial livers but also those in the sheep study would not lead to exceedance of the current TDI for PFOS set by EFSA. Therefore, it can be assumed that they do not present a risk for human health.

  4. Prose reading in neglect.

    Science.gov (United States)

    Beschin, Nicoletta; Cisari, Carlo; Cubelli, Roberto; Della Sala, Sergio

    2014-02-01

    Prose reading has been shown to be a very sensitive measure of Unilateral Spatial Neglect. However, little is known about the relationship between prose reading and other measures of neglect and its severity, or between prose reading and single word reading. Thirty participants with a first stroke in the right hemisphere and clear symptoms of spatial neglect in everyday life were assessed with tests of prose reading (text in one column book-like, and in two columns magazine-like), single words reading, and a battery of 13 tests investigating neglect. Seventy percent of these participants omitted words at the beginning of the text (left end), showing Prose Reading Neglect (PRN). The participants showing PRN differed from those not showing PRN only for the overall severity of neglect, and had a lesion centred on the insula, putamen and superior temporal gyrus. Double dissociations emerged between PRN and single word reading neglect, suggesting different cognitive requirements between the two tests: parallel processing in single word reading vs. serial analysis in text reading. Notably, the pattern of neglected text varied dramatically across participants presenting with PRN, including dissociations between reading performance of one and two columns text. Prose reading proved a complex and unique task which should be directly investigated to predict the effects of unilateral neglect. The outcome of this study should also inform clinical assessment and advises given to patients and care-givers.

  5. Duloxetine and 8-OH-DPAT, but not fluoxetine, reduce depression-like behaviour in an animal model of chronic neuropathic pain.

    Science.gov (United States)

    Hu, Bing; Doods, Henri; Treede, Rolf-Detlef; Ceci, Angelo

    2016-04-21

    The current study assessed whether antidepressant and/or antinociceptive drugs, duloxetine, fluoxetine as well as (±)-8-hydroxy-2-[di-n-propylamino] tetralin (8-OH-DPAT), are able to reverse depression-like behaviour in animals with chronic neuropathic pain. Chronic constriction injury (CCI) of the sciatic nerve in rats was selected as neuropathic pain model. Mechanical hypersensitivity and depression-like behaviour were evaluated 4 weeks after surgery by "electronic algometer" and forced swimming test (FST), which measured the time of immobility, and active behaviours climbing and swimming. The selective noradrenergic and serotonergic uptake blocker duloxetine (20mg/kg) and the selective 5-HT1A agonist 8-OH-DPAT (0.5mg/kg) significantly reversed both mechanical hypersensitivity and depression-like behaviour in CCI animals. Duloxetine significantly reversed depression-like behaviour in CCI rats by increasing the time of climbing and swimming, while 8-OH-DPAT attenuated depression-like behaviour mainly by increasing the time of swimming. However, the selective serotonergic uptake blocker fluoxetine (20mg/kg) failed to attenuate mechanical hypersensitivity and depression-like behaviour, possibly due to confounding pro-nociceptive actions at 5-HT3 receptors. These data suggest to target noradrenergic and 5-HT1A receptors for treatment of chronic pain and its comorbidity depression.

  6. Expression profiling of a genetic animal model of depression reveals novel molecular pathways underlying depressive-like behaviours.

    Directory of Open Access Journals (Sweden)

    Ekaterini Blaveri

    Full Text Available BACKGROUND: The Flinders model is a validated genetic rat model of depression that exhibits a number of behavioural, neurochemical and pharmacological features consistent with those observed in human depression. PRINCIPAL FINDINGS: In this study we have used genome-wide microarray expression profiling of the hippocampus and prefrontal/frontal cortex of Flinders Depression Sensitive (FSL and control Flinders Depression Resistant (FRL lines to understand molecular basis for the differences between the two lines. We profiled two independent cohorts of Flinders animals derived from the same colony six months apart, each cohort statistically powered to allow independent as well as combined analysis. Using this approach, we were able to validate using real-time-PCR a core set of gene expression differences that showed statistical significance in each of the temporally distinct cohorts, representing consistently maintained features of the model. Small but statistically significant increases were confirmed for cholinergic (chrm2, chrna7 and serotonergic receptors (Htr1a, Htr2a in FSL rats consistent with known neurochemical changes in the model. Much larger gene changes were validated in a number of novel genes as exemplified by TMEM176A, which showed 35-fold enrichment in the cortex and 30-fold enrichment in hippocampus of FRL animals relative to FSL. CONCLUSIONS: These data provide significant insights into the molecular differences underlying the Flinders model, and have potential relevance to broader depression research.

  7. Animals

    Institute of Scientific and Technical Information of China (English)

    杨光

    2000-01-01

    The largest animal ever to live on the earth is the blue whale(蓝鲸)It weighs about 80 tons--more than 24 elephants. It is more than 30 metres long. A newborn baby whale weighs as much as a big elephant.

  8. ANIMALS

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Mammals(哺乳动物)Mammals are the world's most dominant(最占优势的)animal.They are extremely(非常)diverse(多种多样的)creatures(生物,动物)that include(包括)the biggest ever animal (the blue whale鲸,which eats up to 6 tons every day),the smallest(leaf-nosed bat小蹄蝠) and the laziest(sloth树獭,who spends 80% of their time sleeping).There are over 4,600 kinds of mammals and they live in very different environments(环境)—oceans(海洋),rivers,the jungle(丛林),deserts,and plains(平原).

  9. Upper Secondary and First-Year University Students' Explanations of Animal Behaviour: To What Extent Are Tinbergen's Four Questions about Causation, Ontogeny, Function and Evolution, Represented?

    Science.gov (United States)

    Pinxten, Rianne; Desclée, Mathieu; Eens, Marcel

    2016-01-01

    In 1963, the Nobel Prize-winning ethologist Niko Tinbergen proposed a framework for the scientific study of animal behaviour by outlining four questions that should be answered to have a complete understanding: causation, ontogeny, function and evolution. At present, Tinbergen's framework is still considered the best way to guide animal…

  10. Elder Abuse and Neglect

    Directory of Open Access Journals (Sweden)

    Muge Gulen

    2013-06-01

    Full Text Available Abuse and neglect are preventable societal problems that influence elderly individuals physically, spiritually and socially. Elder abuse is neglected for many years and is a growing problem all over the world. The aim of this article is to review the evaluation of elderly individuals who are exposed to abuse and neglect with systematic detailed history and physical examination and to describe individual, familial, and social measures that should be taken to prevent these abuses. [Archives Medical Review Journal 2013; 22(3.000: 393-407

  11. Advocacy and child neglect.

    Science.gov (United States)

    Krugman, Scott D

    2014-11-01

    Pediatricians have a unique opportunity to intervene in the lives of children to identify and to prevent neglect. While it remains important to care for individual patients affected by neglect, the ecological model of child neglect requires intervention at the parent, family, community, and societal levels. Pediatricians can improve the outcomes for children by advocating for policies and interventions at each level. Effective advocacy principally requires the willingness to tackle broader issues beyond individual clinical care. Working with local, state, and national organizations, pediatricians can contribute a unified voice to promote evidence-based policies and programs that improve the well-being of children.

  12. The Directive 2010/63/EU on animal experimentation may skew the conclusions of pharmacological and behavioural studies.

    Science.gov (United States)

    Macrì, Simone; Ceci, Chiara; Altabella, Luisa; Canese, Rossella; Laviola, Giovanni

    2013-01-01

    All laboratory animals shall be provided some form of environmental enrichment (EE) in the nearest future (Directive 2010/63/EU). Displacing standard housing with EE entails the possibility that data obtained under traditional housing may be reconsidered. Specifically, while EE often contrasts the abnormalities of consolidated disease models, it also indirectly demonstrates that their validity depends on housing conditions. We mimicked a situation in which the consequences of a novel pharmacological compound were addressed before and after the adoption of the Directive. We sub-chronically exposed standard- or EE-reared adolescent CD1 mice (postnatal days 23-33) to the synthetic compound JWH-018, and evaluated its short- and long-term potential cannabinoid properties on: weight gain, locomotion, analgesia, motor coordination, body temperature, brain metabolism ((1)H MRI/MRS), anxiety- and depressive-related behaviours. While several parameters are modulated by JWH-018 independently of housing, other effects are environmentally mediated. The transition from standard housing to EE shall be carefully monitored.

  13. Cognitive and neural correlates of depression-like behaviour in socially defeated mice: an animal model of depression with cognitive dysfunction.

    Science.gov (United States)

    Yu, Tao; Guo, Ming; Garza, Jacob; Rendon, Samantha; Sun, Xue-Li; Zhang, Wei; Lu, Xin-Yun

    2011-04-01

    Human depression is associated with cognitive deficits. It is critical to have valid animal models in order to investigate mechanisms and treatment strategies for these associated conditions. The goal of this study was to determine the association of cognitive dysfunction with depression-like behaviour in an animal model of depression and investigate the neural circuits underlying the behaviour. Mice that were exposed to social defeat for 14 d developed depression-like behaviour, i.e. anhedonia and social avoidance as indicated by reduced sucrose preference and decreased social interaction. The assessment of cognitive performance of defeated mice demonstrated impaired working memory in the T-maze continuous alternation task and enhanced fear memory in the contextual and cued fear-conditioning tests. In contrast, reference learning and memory in the Morris water maze test were intact in defeated mice. Neuronal activation following chronic social defeat was investigated by c-fosin-situ hybridization. Defeated mice exhibited preferential neural activity in the prefrontal cortex, cingulate cortex, hippocampal formation, septum, amygdala, and hypothalamic nuclei. Taken together, our results suggest that the chronic social defeat mouse model could serve as a valid animal model to study depression with cognitive impairments. The patterns of neuronal activation provide a neural basis for social defeat-induced changes in behaviour.

  14. Child neglect: assessment and intervention.

    Science.gov (United States)

    Hornor, Gail

    2014-01-01

    Neglect is often a neglected form of child maltreatment even though it is the most common and deadliest form of child maltreatment. Pediatric nurse practitioners (PNPs) will most likely encounter neglected children in their practice. It is crucial that PNPs recognize child neglect in a timely manner and intervene appropriately. This continuing education article will help PNPs understand and respond to child neglect. Neglect will be defined and risk factors will be discussed. Children who are neglected can experience serious and lifelong consequences. The medical assessment and plan of care for children with concerns of suspected neglect will be discussed.

  15. Neuropeptide S alters anxiety, but not depression-like behaviour in Flinders Sensitive Line rats: a genetic animal model of depression.

    Science.gov (United States)

    Wegener, Gregers; Finger, Beate C; Elfving, Betina; Keller, Kirsten; Liebenberg, Nico; Fischer, Christina W; Singewald, Nicolas; Slattery, David A; Neumann, Inga D; Mathé, Aleksander A

    2012-04-01

    Neuropeptide S (NPS) and its receptor (NPSR) have been implicated in the mediation of anxiolytic-like behaviour in rodents. However, little knowledge is available regarding the NPS system in depression-related behaviours, and whether NPS also exerts anxiolytic effects in an animal model of psychopathology. Therefore, the aim of this work was to characterize the effects of NPS on depression- and anxiety-related parameters, using male and female rats in a well-validated animal model of depression: the Flinders Sensitive Line (FSL), their controls, the Flinders Resistant Line (FRL), and Sprague-Dawley (SD) rats. We found that FSL showed greater immobility in the forced swim test (FST) than FRL, confirming their phenotype. However, NPS did not affect depression-related behaviour in any rat line. No significant differences in baseline anxiety levels between the FSL and FRL strains were observed, but FSL and FRL rats displayed less anxiety-like behaviour compared to SD rats. NPS decreased anxiety-like behaviour on the elevated plus-maze in all strains. The expression of the NPSR in the amygdala, periventricular hypothalamic nucleus, and hippocampus was equal in all male strains, although a trend towards reduced expression within the amygdala was observed in FSL rats compared to SD rats. In conclusion, NPS had a marked anxiolytic effect in FSL, FRL and SD rats, but did not modify the depression-related behaviour in any strain, in spite of the significant differences in innate level between the strains. These findings suggest that NPS specifically modifies anxiety behaviour but cannot overcome/reverse a genetically mediated depression phenotype.

  16. Attending to and neglecting people: bridging neuroscience, psychology and sociology

    Science.gov (United States)

    Hari, Riitta; Sams, Mikko; Nummenmaa, Lauri

    2016-01-01

    Human behaviour is context-dependent—based on predictions and influenced by the environment and other people. We live in a dynamic world where both the social stimuli and their context are constantly changing. Similar dynamic, natural stimuli should, in the future, be increasingly used to study social brain functions, with parallel development of appropriate signal-analysis methods. Understanding dynamic neural processes also requires accurate time-sensitive characterization of the behaviour. To go beyond the traditional stimulus–response approaches, brain activity should be recorded simultaneously from two interacting subjects to reveal why human social interaction is critically different from just reacting to each other. This theme issue on Attending to and neglecting people contains original work and review papers on person perception and social interaction. The articles cover research from neuroscience, psychology, robotics, animal interaction research and microsociology. Some of the papers are co-authored by scientists who presented their own, independent views in the recent Attention and Performance XXVI conference but were brave enough to join forces with a colleague having a different background and views. In the future, information needs to converge across disciplines to provide us a more holistic view of human behaviour, its interactive nature, as well as the temporal dynamics of our social world. PMID:27069043

  17. Attending to and neglecting people: bridging neuroscience, psychology and sociology.

    Science.gov (United States)

    Hari, Riitta; Sams, Mikko; Nummenmaa, Lauri

    2016-05-05

    Human behaviour is context-dependent-based on predictions and influenced by the environment and other people. We live in a dynamic world where both the social stimuli and their context are constantly changing. Similar dynamic, natural stimuli should, in the future, be increasingly used to study social brain functions, with parallel development of appropriate signal-analysis methods. Understanding dynamic neural processes also requires accurate time-sensitive characterization of the behaviour. To go beyond the traditional stimulus-response approaches, brain activity should be recorded simultaneously from two interacting subjects to reveal why human social interaction is critically different from just reacting to each other. This theme issue on Attending to and neglecting people contains original work and review papers on person perception and social interaction. The articles cover research from neuroscience, psychology, robotics, animal interaction research and microsociology. Some of the papers are co-authored by scientists who presented their own, independent views in the recent Attention and Performance XXVI conference but were brave enough to join forces with a colleague having a different background and views. In the future, information needs to converge across disciplines to provide us a more holistic view of human behaviour, its interactive nature, as well as the temporal dynamics of our social world.

  18. Neglected Parasitic Infections: Toxocariasis

    Centers for Disease Control (CDC) Podcasts

    2012-01-05

    This podcast is an overview of the Clinician Outreach and Communication Activity (COCA) Call: Neglected Parasitic Infections in the United States. Neglected Parasitic Infections are a group of diseases that afflict vulnerable populations and are often not well studied or diagnosed. A subject matter expert from CDC's Division of Parasitic Diseases and Malaria describes the epidemiology, diagnosis, and treatment of toxocariasis.  Created: 1/5/2012 by Center for Global Health, Division of Parasitic Diseases and Malaria (DPDM); Emergency Risk Communication Branch (ERCB)/Joint Information Center (JIC), Office of Public Health Preparedness and Response (OPHPR).   Date Released: 1/9/2012.

  19. Influence of Municipal Abattoir Conditions and Animal-related Factors on Avoidance-related Behaviour, Bleeding Times at Slaughter and the Quality of Lamb Meat.

    Science.gov (United States)

    Njisane, Yonela Z; Muchenje, Voster

    2013-10-01

    The objective of this study was to determine the effect of municipal abattoir conditions and animal factors on avoidance-related behaviour (AB) of sheep at slaughter, bleeding times (BT) and mutton quality. The behaviour of 66 castrates and 19 ewes of different age categories was observed at three stages of slaughter. Higher behaviour scores indicated higher levels of AB. Time intervals between the start of blood flow and the time the flow changed from a constant stream into drips were recorded as BT. Thirty two meat samples were obtained to measure quality variables. These were colour (L*, a* and b*), pH24, temperature, cooking loss (CL) and tenderness. Correlations were determined between BT and meat quality variables. Animal behaviour at slaughter differed with breed, gender and age group. Avoidance behaviour was higher in the Dorper breed than in both the Merino breed and their crosses. It was also higher in younger (<10 months) lambs than in older sheep. Castrates were more aggressive or in panic than ewes. Castrates had longer (72.6±0.53 s) BT than the ewes (63.6±2.82 s). Ewes had higher CL (39.8±1.04%) values than castrates (35.1±0.95%). Meat from castrates was tougher (32.6±1.95 N) than the meat from ewes (24.3±1.16 N). There were no significant correlations obtained between BT and meat quality variables. It can therefore be concluded that abattoir conditions, breed, age and gender had an effect on AB at slaughter. Gender had an effect on BT and mutton quality.

  20. Neglected vaginal pessary

    Directory of Open Access Journals (Sweden)

    Meenu Jain

    2014-02-01

    Full Text Available Vaginal pessary may be opted for management of uterine prolapse as a safe option, but to avoid complications regular follow-up is a must. We are reporting a case of neglected vaginal pessary in a 72 year old female which got embedded in vaginal mucosa and required excision of vaginal band for its removal. [Int J Reprod Contracept Obstet Gynecol 2014; 3(1.000: 291-292

  1. The long-term effects of methamphetamine exposure during pre-adolescence on depressive-like behaviour in a genetic animal model of depression.

    Science.gov (United States)

    Mouton, Moné; Harvey, Brian H; Cockeran, Marike; Brink, Christiaan B

    2016-02-01

    Methamphetamine (METH) is a psychostimulant and drug of abuse, commonly used early in life, including in childhood and adolescence. Adverse effects include psychosis, anxiety and mood disorders, as well as increased risk of developing a mental disorder later in life. The current study investigated the long-term effects of chronic METH exposure during pre-adolescence in stress-sensitive Flinders Sensitive Line (FSL) rats (genetic model of depression) and control Flinders Resistant Line (FRL) rats. METH or vehicle control was administered twice daily from post-natal day 19 (PostND19) to PostND34, followed by behavioural testing at either PostND35 (early effects) or long-lasting after withdrawal at PostND60 (early adulthood). Animals were evaluated for depressive-like behaviour, locomotor activity, social interaction and object recognition memory. METH reduced depressive-like behaviour in both FSL and FRL rats at PostND35, but enhanced this behaviour at PostND60. METH also reduced locomotor activity on PostND35 in both FSL and FRL rats, but without effect at PostND60. Furthermore, METH significantly lowered social interaction behaviour (staying together) in both FRL and FSL rats at PostND35 and PostND60, whereas self-grooming time was significantly reduced only at PostND35. METH treatment enhanced exploration of the familiar vs. novel object in the novel object recognition test (nORT) in FSL and FRL rats on PostND35 and PostND60, indicative of reduced cognitive performance. Thus, early-life METH exposure induce social and cognitive deficits. Lastly, early-life exposure to METH may result in acute antidepressant-like effects immediately after chronic exposure, whereas long-term effects after withdrawal are depressogenic. Data also supports a role for genetic predisposition as with FSL rats.

  2. Animal models of autism with a particular focus on the neural basis of changes in social behaviour: an update article.

    Science.gov (United States)

    Olexová, Lucia; Talarovičová, Alžbeta; Lewis-Evans, Ben; Borbélyová, Veronika; Kršková, Lucia

    2012-12-01

    Research on autism has been gaining more and more attention. However, its aetiology is not entirely known and several factors are thought to contribute to the development of this neurodevelopmental disorder. These potential contributing factors range from genetic heritability to environmental effects. A significant number of reviews have already been published on different aspects of autism research as well as focusing on using animal models to help expand current knowledge around its aetiology. However, the diverse range of symptoms and possible causes of autism have resulted in as equally wide variety of animal models of autism. In this update article we focus only on the animal models with neurobehavioural characteristics of social deficit related to autism and present an overview of the animal models with alterations in brain regions, neurotransmitters, or hormones that are involved in a decrease in sociability.

  3. Effect of animal-borne camera and flash on the diving behaviour of the female Antarctic fur seal ( Arctocephalus gazella)

    Science.gov (United States)

    Heaslip, Susan G.; Hooker, Sascha K.

    2008-09-01

    Studies have documented effects of drag created by data-logging units attached to seals, but the effect of visual stimuli from such units has not been investigated. We evaluated potential effects of camera attachment including near-infrared flash operation by comparing the diving behaviour of 15 female Antarctic fur seals ( Arctocephalus gazella) with cameras and 10 seals without cameras. Irrespective of the presence of the camera or flash, all seals exhibited an expected diel dive pattern with shallower, shorter dives, less time at the bottom of a dive, and slower ascent and descent rates at night following krill vertical migration. We also observed a previously unreported foraging trip dive pattern with faster ascents and descents near the end of trips. With cameras present, dive duration and bottom time increased and ascents were slower. During flash operation, dive duration increased and bottom time remained constant throughout the day contrary to the expected diel trend. Also during flash operation, bottom time was shorter at the beginning of a foraging trip and dives were deeper, with longer duration and bottom time later in the trip. We were unable to conclude whether the flash emission spectrum overlapped with the visual sensitivity of seals and Antarctic krill ( Euphausia superba) since visual sensitivity data for seals and krill at longer wavelengths were not available. It is possible that the flash was bright enough for the seals or krill to detect; however, although there was a change in diving behaviour observed during flash operation this behaviour was within the range of values normally observed for these seals and should not cause ethical concern.

  4. Mirror neuron therapy for hemispatial neglect patients

    Science.gov (United States)

    Wang, Wei; Zhang, Xin; Ji, Xiangtong; Ye, Qian; Chen, Wenli; Ni, Jun; Shen, Guangyu; Zhang, Bing; Yuan, Ti-Fei; Shan, Chunlei

    2015-01-01

    Mirror neuron system(MNS) based therapy has been employed to treat stroke induced movement disorders. However, its potential effects on patients with hemispatial neglect were uninvestigated. The present study set out to test the therapeutic efficiency of video watching of series of hand actions/movements (protocol A) in two patients with left hemispatial neglect, due to the right hemisphere stroke. The video containing dynamic landscape of natural scene or cities but not human/animals was used as the protocol B. The “ABA” training procedure for 3 weeks therefore allows us to internally control the individual differences. Before and after each week of training, the Chinese behavioral inattention test- Hongkong version (CBIT-HK) was implemented to evaluate the hemispatial neglect severity. Functional magnetic resonance imaging (fMRI) experiment was implemented in two health subjects to reveal the difference of brain activation between protocol A and B. The results showed that protocol A rather than protocol B significantly improved the CBIT-HK scores at first and third weeks, respectively. Protocol A induced more bilateral activations including right inferior parietal lobe (supramarginal gyrus), which belongs to MNS and is also critical region resulting to hemineglect. Conclusion: MNS activation can provide a novel therapy for hemispatial neglect patients. PMID:25727354

  5. More Ideas for Monitoring Biological Experiments with the BBC Computer: Absorption Spectra, Yeast Growth, Enzyme Reactions and Animal Behaviour.

    Science.gov (United States)

    Openshaw, Peter

    1988-01-01

    Presented are five ideas for A-level biology experiments using a laboratory computer interface. Topics investigated include photosynthesis, yeast growth, animal movements, pulse rates, and oxygen consumption and production by organisms. Includes instructions specific to the BBC computer system. (CW)

  6. Rapid urbanization of red foxes in Estonia: distribution, behaviour, attacks on domestic animals, and health-risks related to zoonotic diseases.

    Directory of Open Access Journals (Sweden)

    Liivi Plumer

    Full Text Available Urban areas are becoming increasingly important for wildlife as diminishing natural habitats no longer represent a suitable environment for many species. Red foxes (Vulpes vulpes are nowadays common in many cities worldwide, and in recent years they have colonized urban areas in Estonia. We used a public web-based questionnaire approach to evaluate the distribution and behaviour of Estonian urban foxes, to detect related problems and to assess health risks to humans and domestic animals. In total, 1205 responses were collected throughout the country. Foxes have colonized the majority of Estonian towns (33 out of 47 in a relatively short period of time, and have already established breeding dens in several towns. Despite their recent arrival, the behaviour of Estonian urban foxes is similar to that reported in longer-established urban fox populations: they are mostly active during night-time, often visit city centres and some also have dens in such locations. Certain characteristics of urban foxes serve as a basis for conflict with humans: foxes have entered houses and attacked domestic animals, killing cats and poultry. About 8% of reported foxes exhibited symptoms of sarcoptic mange, a disease that also infects domestic animals, especially dogs. The proportion of mange-infected foxes was higher in large urban areas. In addition to mange, a substantial fraction of red foxes in Estonia are known to be infected with the life-threatening tapeworm Echinococcus multilocularis, the causative agent of alveolar echinococcosis. Therefore, urban foxes may represent a source of serious infectious disease for pets and humans.

  7. Rapid Urbanization of Red Foxes in Estonia: Distribution, Behaviour, Attacks on Domestic Animals, and Health-Risks Related to Zoonotic Diseases

    Science.gov (United States)

    Plumer, Liivi; Davison, John; Saarma, Urmas

    2014-01-01

    Urban areas are becoming increasingly important for wildlife as diminishing natural habitats no longer represent a suitable environment for many species. Red foxes (Vulpes vulpes) are nowadays common in many cities worldwide, and in recent years they have colonized urban areas in Estonia. We used a public web-based questionnaire approach to evaluate the distribution and behaviour of Estonian urban foxes, to detect related problems and to assess health risks to humans and domestic animals. In total, 1205 responses were collected throughout the country. Foxes have colonized the majority of Estonian towns (33 out of 47) in a relatively short period of time, and have already established breeding dens in several towns. Despite their recent arrival, the behaviour of Estonian urban foxes is similar to that reported in longer-established urban fox populations: they are mostly active during night-time, often visit city centres and some also have dens in such locations. Certain characteristics of urban foxes serve as a basis for conflict with humans: foxes have entered houses and attacked domestic animals, killing cats and poultry. About 8% of reported foxes exhibited symptoms of sarcoptic mange, a disease that also infects domestic animals, especially dogs. The proportion of mange-infected foxes was higher in large urban areas. In addition to mange, a substantial fraction of red foxes in Estonia are known to be infected with the life-threatening tapeworm Echinococcus multilocularis, the causative agent of alveolar echinococcosis. Therefore, urban foxes may represent a source of serious infectious disease for pets and humans. PMID:25531399

  8. Development of automatic surveillance of animal behaviour and welfare using image analysis and machine learned segmentation technique.

    Science.gov (United States)

    Nilsson, M; Herlin, A H; Ardö, H; Guzhva, O; Åström, K; Bergsten, C

    2015-11-01

    In this paper the feasibility to extract the proportion of pigs located in different areas of a pig pen by advanced image analysis technique is explored and discussed for possible applications. For example, pigs generally locate themselves in the wet dunging area at high ambient temperatures in order to avoid heat stress, as wetting the body surface is the major path to dissipate the heat by evaporation. Thus, the portion of pigs in the dunging area and resting area, respectively, could be used as an indicator of failure of controlling the climate in the pig environment as pigs are not supposed to rest in the dunging area. The computer vision methodology utilizes a learning based segmentation approach using several features extracted from the image. The learning based approach applied is based on extended state-of-the-art features in combination with a structured prediction framework based on a logistic regression solver using elastic net regularization. In addition, the method is able to produce a probability per pixel rather than form a hard decision. This overcomes some of the limitations found in a setup using grey-scale information only. The pig pen is a difficult imaging environment because of challenging lighting conditions like shadows, poor lighting and poor contrast between pig and background. In order to test practical conditions, a pen containing nine young pigs was filmed from a top view perspective by an Axis M3006 camera with a resolution of 640 × 480 in three, 10-min sessions under different lighting conditions. The results indicate that a learning based method improves, in comparison with greyscale methods, the possibility to reliable identify proportions of pigs in different areas of the pen. Pigs with a changed behaviour (location) in the pen may indicate changed climate conditions. Changed individual behaviour may also indicate inferior health or acute illness.

  9. Interfacial behaviour between oil/water systems using ionic surfactants from regional vegetable industry and animal pet

    Energy Technology Data Exchange (ETDEWEB)

    Santos, Francisco Klebson G.; Alves, Juan V.A.; Dantas, Tereza N. Castro; Dutra Junior, Tarcilio V.; Barros Neto, Eduardo L. [Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN (Brazil)

    2008-07-01

    Interfacial tension (IFT) is one of the most important physical properties in the study of fluid-fluid interfaces. In this research the surfactants - saponified coconut oil, saponified castor oil, saponified soybean oil, saponified sunflower oil and basis soap - were synthesized in laboratory, using carboxylic acids from regional industry and animal fat (bovine fat). This study focuses on the search of a high-efficient, low-cost, and safe for the environment flooding system to be applied in enhanced oil recovery. The principal aim of this work is the obtaining of interfacial tensions between oil/water systems, using the developed ionic surfactants. Results showed that the studied surfactants are able to reduce the IFT between oil and brine. The surfactant that was more effective in reducing the IFT value was the one from animal fat. The composition, as well as the kind of the bond, as saturated or unsaturated, of the surfactants has influence in the IFT value. The ionic surfactants from regional industry and animal fat besides presenting low cost propitiate very low interfacial tensions between oil and brine, favoring the interactions with residual oil and thus increasing oil recovery. (author)

  10. Animal models of human psychopathology based on individual differences in novelty-seeking and anxiety.

    Science.gov (United States)

    Pawlak, Cornelius R; Ho, Ying-Jui; Schwarting, Rainer K W

    2008-10-01

    The role of individual factors in behavioural neuroscience is an important, but still neglected area of research. The present review aims to give, first, an outline of the most elaborated theory on animal behaviour, and second, an overview of systematic approaches of historic and present animal models of human psychopathology based on individual differences. This overview will be focused on animal models of unselected subjects (i.e. natural variance of a specific behaviour within a given population) and selected breeding for a specific behaviour. Accordingly, an outline of the personality model from Gray and McNaughton of individual behaviour in animals is given first. Then, a comprehensive overview of past and current animal models in novelty-seeking (i.e. psychomotor activation and exploration behaviour) based on systematic individual differences and its relationship to addiction is presented. Third, this will be followed by a comprehensive overview of individual differences in previous and present animal models for anxiety. Finally, critical aspects of such approaches in animal research are discussed, and suggestions are given where to go from here.

  11. Lyme borreliosis: A neglected zoonosis in Egypt.

    Science.gov (United States)

    Elhelw, Rehab A; El-Enbaawy, Mona I; Samir, Ahmed

    2014-12-01

    Borrelia burgdorferi, the causal organism of Lyme borreliosis. In Egypt, available data about the occurrence of Lyme disease are scarce and no structured studies documented the presence of Lyme borreliosis in Egyptian animals and tick reservoirs verifying its zoonotic evidence. Besides, no successful trials to isolate B. burgdorferi from clinical samples have occurred. This study was conducted to investigate B. burgdorferi infection as an emerging zoonosis neglected in Egypt. A total number of 92 animals, tick and human companion specimens were collected and subjected for culture, PCR and/or serodetection. B. burgdorferi has been detected and isolated from Egyptian animal breeds. We also detected the presence of outer surface protein A gene of B. burgdorferi by PCR as well as anti-B. burgdorferi IgM by ELISA in human contacts who were suffering from fever of unknown origin. This report represents the first systematic study on animals associated with patients suffering from febrile illness to confirm the emerging of such neglected zoonosis in Egypt.

  12. Neglected hangman fracture

    Directory of Open Access Journals (Sweden)

    Sudhir Kumar Srivastava

    2015-01-01

    Full Text Available Acute management of hangman fracture is well described; however the surgical management of neglected hangman fracture has not been described in literature. We report the surgical management of an untreated hangman′s fracture. A 30-year-old male had fallen from a tree 12 weeks back. Patient presented with cervical myelopathy and restricted neck movements. Radiographs and computed tomography (CT scan revealed fracture of pars interarticularis of axis with Grade III C2-C3 spondylolisthesis with localized kyphosis of 33°. Gentle reduction under general anesthesia (GA failed to improve the alignment. Patient was operated in three stages in a single setting. In Stage I, release of contracted anterior structures and C2-C3 discectomy was done in supine position followed by C2-C3 posterior fixation and fusion in Stage II. C2-C3 interbody bone grafting and anterior plating completed the third stage. C2-C3 interbody fusion was seen at 5 months and a CT scan at 18 months postoperative confirmed fusion and maintenance of alignment. The satisfactory outcome in our patient leads us to believe that anterior-posterior-anterior is the appropriate surgical approach for treatment of such patients.

  13. Theta burst stimulation reduces disability during the activities of daily living in spatial neglect.

    Science.gov (United States)

    Cazzoli, Dario; Müri, René M; Schumacher, Rahel; von Arx, Sebastian; Chaves, Silvia; Gutbrod, Klemens; Bohlhalter, Stephan; Bauer, Daniel; Vanbellingen, Tim; Bertschi, Manuel; Kipfer, Stefan; Rosenthal, Clive R; Kennard, Christopher; Bassetti, Claudio L; Nyffeler, Thomas

    2012-11-01

    Left-sided spatial neglect is a common neurological syndrome following right-hemispheric stroke. The presence of spatial neglect is a powerful predictor of poor rehabilitation outcome. In one influential account of spatial neglect, interhemispheric inhibition is impaired and leads to a pathological hyperactivity in the contralesional hemisphere, resulting in a biased attentional allocation towards the right hemifield. Inhibitory transcranial magnetic stimulation can reduce the hyperactivity of the contralesional, intact hemisphere and thereby improve spatial neglect symptoms. However, it is not known whether this improvement is also relevant to the activities of daily living during spontaneous behaviour. The primary aim of the present study was to investigate whether the repeated application of continuous theta burst stimulation trains could ameliorate spatial neglect on a quantitative measure of the activities of daily living during spontaneous behaviour. We applied the Catherine Bergego Scale, a standardized observation questionnaire that can validly and reliably detect the presence and severity of spatial neglect during the activities of daily living. Eight trains of continuous theta burst stimulation were applied over two consecutive days on the contralesional, left posterior parietal cortex in patients suffering from subacute left spatial neglect, in a randomized, double-blind, sham-controlled design, which also included a control group of neglect patients without stimulation. The results showed a 37% improvement in the spontaneous everyday behaviour of the neglect patients after the repeated application of continuous theta burst stimulation. Remarkably, the improvement persisted for at least 3 weeks after stimulation. The amelioration of spatial neglect symptoms in the activities of daily living was also generally accompanied by significantly better performance in the neuropsychological tests. No significant amelioration in symptoms was observed after sham

  14. Self-Neglect: Ethical Considerations.

    Science.gov (United States)

    Day, Mary Rose; Leahy-Warren, Patricia; McCarthy, Geraldine

    2016-01-01

    Self-neglect is a significant international public health issue. Estimates suggest that there may be over one million cases per year in the United States. Aging populations will put more people at risk of self-neglect. This chapter presents background literature, self-neglect definitions and policy context, risk factors, and a brief overview of research on perspectives of self-neglect from both clients and community health and social care professionals. A case study is presented from the perspective of an individual and is used to explore ethical issues therein. A person-centered assessment within a multidisciplinary team approach is required for building a therapeutic relationship with clients. Capacity is a central issue in the management of responses to self-neglect. Ethical considerations of importance for community health and social care professionals include beneficence and nonmaleficence, autonomy and capacity, and respect for people's rights and dignity. A model of ethical justification is presented to explain dilemmas, challenges, and actions. Competence of professionals, multidisciplinary team working, informed consent, privacy, confidentiality, and best interest are also critical considerations. Effective decision making by an interdisciplinary team of professionals needs to be person-centered and give due consideration to the best interest of self-neglecting clients. The purpose of this chapter is to provide an in-depth discussion and examination of ethical issues and challenges relating to self-neglecting clients.

  15. Introductory keynote. The state of the art in animal experimentation.

    Science.gov (United States)

    Alleva, Enrico; Scattoni, Maria Luisa

    2004-01-01

    This issue of Annali dell'Istituto Superiore di Sanità critically evaluates the progression in the ethical relationship between humans and animals (i.e., between biomedical researchers and laboratory animals). The main goal of this publication is in fact to provide a basis for an in-depth discussion of highly debated topics in the contemporary bioethics of animal experimentation, with particular focus on ethological issues and the question of minimal sample size and its contribution to reducing the number of experimental animals. The ethological issues addressed in this publication cover all behavioural patterns specifically moulded by the phylogenetic and ontogenetical history of a given species, a perspective that is often neglected when discussing the promotion of animal welfare.

  16. Patient neglect in 21st century health-care institutions: a community health psychology perspective.

    Science.gov (United States)

    Reader, Tom W; Gillespie, Alex; Mannell, Jenevieve

    2014-01-01

    Despite the technological and organisational advances of 21st century health-care systems, care scandals and burgeoning complaints from patients have raised concerns about patient neglect in hospitals. This article reviews the concept of patient neglect and the role of community health psychology in understanding its occurrence. Patient neglect has previously been conceptualised as a problem associated with hospital staff attitudes and behaviours, with regulation and training cited as solutions. Yet, a community health psychology perspective shows that the wider symbolic, material and relational aspects of care are crucial for understanding why patient neglect occurs and for outlining new solutions to augment existing interventions.

  17. Child neglect and psychological abuse

    Science.gov (United States)

    ... or neglect, call 911. Call the Childhelp National Child Abuse Hotline (1-800-4-A-CHILD). Know that ... can/identifying/. Accessed November 21, 2014. Read More Child abuse - physical Review Date 11/20/2014 Updated by: ...

  18. Albert's test: a neglected test of perceptual neglect.

    Science.gov (United States)

    Fullerton, K J; McSherry, D; Stout, R W

    1986-02-22

    Disorders of perception are thought to be important in predicting the outcome from stroke, but their exact significance is difficult to define because of lack of standardised terminology and diagnostic methods. In a prospective study of 205 unselected stroke patients, perceptual neglect, assessed by a standardised test battery, was found in 49% of patients with lesions of the non-dominant hemisphere and in 25% with lesions of the dominant hemisphere. One component of the test battery was a simple test described by Albert in which patients cross out lines ruled in a standard fashion on a sheet of paper; this was easy to administer and related closely to neglect diagnosed by the test battery as a whole. Results of Albert's test were a significant predictor of both mortality and functional activity six months after the stroke, independent of the influence of other clinical, neurological, laboratory, and social factors. The full test battery for perceptual neglect was of no significant additional predictive value.

  19. Zinc: the neglected nutrient.

    Science.gov (United States)

    Shambaugh, G E

    1989-03-01

    Zinc was first recognized as essential for animals at the University of Illinois School of Agriculture in 1916, when it was found that zinc-deficient baby pigs were runty, developed dermatitis on their legs, and were sterile. Zinc deficiency was first recognized in man by Dr. Ananda Prasad of Detroit 26 years ago when he measured serum and hair zinc levels in young male Egyptian dwarfs who had failed to mature and were small in stature. By simply adding zinc to their regular diet, they grew in height and became sexually mature. It is now recognized that dwarfism in males is frequent around the Mediterranean, where wheat is the staple of life and has been grown for 4,000 years on the same soil, thereby resulting in the depletion of zinc. Professor Robert Henkin first suggested that zinc deficiency might cause hearing-nerve impairment. Assay of the soft tissues of the cochlea and vestibule revealed a zinc level higher than that of any other part of the body. Previously, the eye was considered to have the highest level of zinc of any organ. To diagnose zinc deficiency clinically, we use serum zinc assays made at the Mayo Clinic Trace Element Laboratory. With zinc supplementation in patients who are marginally zinc deficient, there has been improvement in tinnitus and sensorineural hearing loss in about one-third of elderly adults. We believe zinc deficiency is one causation of presbycusis; by recognizing and correcting it, a progressive hearing loss can be arrested.

  20. Harnessing motivation to alleviate neglect.

    Science.gov (United States)

    Russell, Charlotte; Li, Korina; Malhotra, Paresh A

    2013-01-01

    The syndrome of spatial neglect results from the combination of a number of deficits in attention, with patients demonstrating both spatially lateralized and non-lateralized impairments. Previous reports have hinted that there may be a motivational component to neglect and that modulating this might alleviate some of the debilitating symptoms. Additionally, recent work on the effects of reward on attention in healthy participants has revealed improvements across a number of paradigms. As the primary deficit in neglect has been associated with attention, this evidence for reward's effects is potentially important. However, until very recently there have been few empirical studies addressing this potential therapeutic avenue. Here we review the growing body of evidence that attentional impairments in neglect can be reduced by motivation, for example in the form of preferred music or anticipated monetary reward, and discuss the implications of this for treatments for these patients. Crucially these effects of positive motivation are not observed in all patients with neglect, suggesting that the consequences of motivation may relate to individual lesion anatomy. Given the key role of dopaminergic systems in motivational processes, we suggest that motivational stimulation might act as a surrogate for dopaminergic stimulation. In addition, we consider the relationship between clinical post stroke apathy and lack of response to motivation.

  1. Harnessing motivation to alleviate neglect

    Directory of Open Access Journals (Sweden)

    Charlotte eRussell

    2013-06-01

    Full Text Available The syndrome of spatial neglect results from the combination of a number of deficits in attention, with patients demonstrating both spatially lateralised and non-lateralised impairments. Previous reports have hinted that there may be a motivational component to neglect and that modulating this might alleviate some of the debilitating symptoms. Additionally, recent work on the effects of reward on attention in healthy participants has revealed improvements across a number of paradigms. As the primary deficit in neglect has been associated with attention, this evidence for reward’s effects is potentially important. However, until very recently there have been few empirical studies addressing this potential therapeutic avenue. Here we review the growing body of evidence that attentional impairments in neglect can be reduced by motivation, for example in the form of preferred music or anticipated monetary reward, and discuss the implications of this for treatments for these patients. Crucially these effects of positive motivation are not observed in all patients with neglect, suggesting that the consequences of motivation may relate to individual lesion anatomy. Given the key role of dopaminergic systems in motivational processes, we suggest that motivational stimulation might act as a surrogate for dopaminergic stimulation. In addition, we consider the relationship between clinical post stroke apathy and lack of response to motivation.

  2. [Current situation of endemic status, prevention and control of neglected zoonotic diseases in China].

    Science.gov (United States)

    Liu, Lu; Zhu, Hong-Run; Yang, Guo-Jing

    2013-06-01

    Neglected zoonotic diseases not only threaten the health of human, especially to the livestock keepers in poverty-stricken areas but also cause great economic losses to the animal husbandry. This paper reviews the current situation of the endemic status, prevention and control of neglected zoonotic diseases existing in China including rabies, bovine tuberculosis, brucellosis, anthrax, leptospirosis, echinococcosis, cysticercosis, leishmaniasis and fascioliasis, so as to provide the basic information for better controlling, even eliminating, the neglected zoonotic diseases in China.

  3. Bienestar Animal: Comportamiento productivo y salud de las crías de cerdos alojadas en tecnología Flat Deck - Animal Well-being: Productive behaviour and health of the breeding of pigs housed in technology Flat Deck

    Directory of Open Access Journals (Sweden)

    Maikel Díaz Gutierrez

    2010-08-01

    Full Text Available ResumenCon el objetivo de evaluar comportamiento productivo y de salud de las crías de cerdos alojados en tecnología Flat Deck se realiza el trabajo Bienestar Animal: Comportamiento productivo y de salud de las crías de cerdos alojadas en tecnología Flat Deck. Para ello se utilizaron 24 bóxer de maternidad de tecnología Flat Deck, de estos 12 de origen chino y 12 de origen español con características similares. Se analizaron un total de 1433 crías mestizas (cruce de hembras Yorkland entre la tercera y cuarta paridad con machos CC-21, L-35 y Duroc. De estas, 715 corresponden a la tecnología de origen chino y 718 a la tecnología de origen español, alojadas aproximadamente a 10 crías por bóxer. Se tuvo en cuenta el tamaño de la camada al nacer (TCN y peso al nacer (PN, peso al destete(PD y ganancia media diaria (GMD; además de los indicadores de salud(enfermos y muertes por tecnología. En los indicadores evaluadosinicialmente que no son influenciados por las tecnologías no sepresentaron diferencias estadísticamente significativas (p>0,05. En los indicadores productivos por tecnología no se encontraron diferencia estadísticamente significativa, encontrándose las medias del peso al destete entre 7.08 y 7.15 y una ganancia media diaria de 219.11 y 221.09 respectivamente. No siendo así para los indicadores de salud, quien fue desfavorable para la tecnología de origen chino donde se presentaron 27 animales enfermos por encima de los enfermos en la tecnología de origen español.SummaryWith the objective of evaluating productive behaviour and of health of the breeding of pigs housed in technology Flat Deck he/she is carried out the work Animal Well-being: Productive behaviour and of health of the breeding of pigs housed in technology Flat Deck. For they were used it 24 boxers of technology maternity Flat Deck, of these 12 of Chinese origin and 12 of Spanish origin with characteristic similar. They were analyzed a total of 1433

  4. Animal welfare: an animal science approach.

    Science.gov (United States)

    Koknaroglu, H; Akunal, T

    2013-12-01

    Increasing world population and demand for animal-derived protein puts pressure on animal production to meet this demand. For this purpose animal breeding efforts were conducted to obtain the maximum yield that the genetic makeup of the animals permits. Under the influence of economics which is the driving force behind animal production, animal farming became more concentrated and controlled which resulted in rearing animals under confinement. Since more attention was given on economics and yield per animal, animal welfare and behavior were neglected. Animal welfare which can be defined as providing environmental conditions in which animals can display all their natural behaviors in nature started gaining importance in recent years. This does not necessarily mean that animals provided with good management practices would have better welfare conditions as some animals may be distressed even though they are in good environmental conditions. Consumers are willing to pay more for welfare-friendly products (e.g.: free range vs caged egg) and this will change the animal production practices in the future. Thus animal scientists will have to adapt themselves for the changing animal welfare rules and regulations that differ for farm animal species and countries. In this review paper, animal welfare is discussed from an animal science standpoint.

  5. Neglected zoonotic helminths: Hymenolepis nana, Echinococcus canadensis and Ancylostoma ceylanicum.

    Science.gov (United States)

    Thompson, R C A

    2015-05-01

    The majority of helminth parasites that are considered by WHO to be the cause of 'neglected diseases' are zoonotic. In terms of their impact on human health, the role of animal reservoirs and polyparasitism are both emerging issues in understanding the epidemiology of a number of these zoonoses. As such, Hymenolepis (Rodentolepis) nana, Echinococcus canadensis and Ancylostoma ceylanicum all qualify for consideration. They have been neglected and there is increasing evidence that all three parasite infections deserve more attention in terms of their impact on public health as well as their control.

  6. Repeated lysergic acid diethylamide in an animal model of depression: Normalisation of learning behaviour and hippocampal serotonin 5-HT2 signalling.

    Science.gov (United States)

    Buchborn, Tobias; Schröder, Helmut; Höllt, Volker; Grecksch, Gisela

    2014-06-01

    A re-balance of postsynaptic serotonin (5-HT) receptor signalling, with an increase in 5-HT1A and a decrease in 5-HT2A signalling, is a final common pathway multiple antidepressants share. Given that the 5-HT1A/2A agonist lysergic acid diethylamide (LSD), when repeatedly applied, selectively downregulates 5-HT2A, but not 5-HT1A receptors, one might expect LSD to similarly re-balance the postsynaptic 5-HT signalling. Challenging this idea, we use an animal model of depression specifically responding to repeated antidepressant treatment (olfactory bulbectomy), and test the antidepressant-like properties of repeated LSD treatment (0.13 mg/kg/d, 11 d). In line with former findings, we observe that bulbectomised rats show marked deficits in active avoidance learning. These deficits, similarly as we earlier noted with imipramine, are largely reversed by repeated LSD administration. Additionally, bulbectomised rats exhibit distinct anomalies of monoamine receptor signalling in hippocampus and/or frontal cortex; from these, only the hippocampal decrease in 5-HT2 related [(35)S]-GTP-gamma-S binding is normalised by LSD. Importantly, the sham-operated rats do not profit from LSD, and exhibit reduced hippocampal 5-HT2 signalling. As behavioural deficits after bulbectomy respond to agents classified as antidepressants only, we conclude that the effect of LSD in this model can be considered antidepressant-like, and discuss it in terms of a re-balance of hippocampal 5-HT2/5-HT1A signalling.

  7. Development of a Micorcontroller-based Instrument for Testing Behaviours of Food and Drink of Animals%微机自动控制动物饮食行为检测仪的研制

    Institute of Scientific and Technical Information of China (English)

    袁勇; 葛尔宁

    2011-01-01

    Objective To develop an instrument that detects the behaviours of food and thrink of animals during pharmacological and bromatological experiments. Methods Consists of infrared sensors, Pressure sensors and Photoelectric sensors were used for signal conversion. Reduction motors were used for channels door control. A SI-Series microcontroller was used to control the experimental setup and record the results. Results We have developed a microcontroller-based instrument that can automatically detects the behaviours of food and thrink of animals during pharmacological and bromatological experiments. Conclusion Our experimental results with 30 mice indicate that the instrument developed provides an innovative tool for detecting the behaviours of food and thrink of animals.%采用红外传感、减速马达和光电传感组合、压力传感、51系列单片微机控制和记忆等技术,研制一种检测动物饮食行为的仪器,用于药物和食品研制中的动物实验.经30例小鼠实验证明,效果良好,该仪器为测定动物饮食行为提供了一种全新的先进方法.

  8. Self-Neglect: Development and Evaluation of a Self-Neglect (SN-37) Measurement Instrument.

    Science.gov (United States)

    Day, Mary Rose; McCarthy, Geraldine

    2016-08-01

    Self-neglect (SN) is a global phenomenon, largely hidden, poorly defined, and a serious public health issue. It can be intentional or unintentional and depends on the individual's capacity. Creating a safe living environment for self-neglecting adults can present complex ethical challenges. The purpose of this research was to develop and evaluate the psychometric properties of an instrument to measure professional's perceptions of self-neglect. A descriptive cross-sectional design was used in this two-stage study. Stage 1 involved the generation of an item pool (90 items), face and content validity; and pilot testing of the instrument. In stage 2, the questionnaire was posted to a national sample of community health and social care professionals (n=566) across Ireland, with a 60% response (n=339). Exploratory factor analysis (EFA) was conducted using scale development guidelines to identify scales and subscales of the instrument. Construct validity was established using EFA. The result was a 37-item SN instrument, composed of five factors: environment, social networks, emotional and behavioural liability, health avoidance, and self-determinism which explained 55.6% of the total variance. Factor loadings were ≥0.40 for all items on each of the five subscales. Cronbach's alpha (α) for four subscales ranged from 0.83 to 0.89 and one subscale was 0.69. The SN-37 can be used not only to measure SN, but also to develop interventions in practice. Further testing of the SN-37 in primary care settings with diverse populations is recommended.

  9. Other Safety Concerns and Self-Neglect

    Science.gov (United States)

    ... Center (NAPSRC) Training Research Exploitation Resources Technical Assistance Other Safety Concerns and Self-Neglect Other safety concerns ... APS office for additional information. When To Report Other Safety Concerns and Self-Neglect? If you witness ...

  10. Childhood neglect: The role of the paediatrician.

    Science.gov (United States)

    Keeshin, Brooks R; Dubowitz, Howard

    2013-10-01

    Neglect is a pervasive form of child maltreatment. Health care practitioners often struggle with deciding when an action (or lack of action) by a caregiver constitutes inadequate care and is neglectful. The present article discusses the epidemiology, risk factors and outcomes of neglect. In addition, assessment using objective markers, such as harm and potential harm, in the identification of neglect is described, and unique factors that impact assessing and addressing issues of neglect in the clinical setting are discussed. Practical strategies for intervening in cases of neglect are discussed, including how to engage families in which there are concerns for neglect, mandated reporting, working collaboratively with children's services, ongoing monitoring of families, and how health care professionals can effectively engage in neglect prevention and advocacy.

  11. What Is Child Abuse and Neglect?

    Science.gov (United States)

    US Department of Health and Human Services, 2006

    2006-01-01

    Each State provides its own definitions of child abuse and neglect based on minimum standards set by Federal law. This fact sheet provides the answers to the following questions: (1) How is child abuse and neglect defined in Federal law?; and (2) What are the major types of child abuse and neglect? Additional resources are listed. (Contains 2…

  12. Visual neglect in posterior cortical atrophy

    Directory of Open Access Journals (Sweden)

    Andrade Katia

    2010-08-01

    Full Text Available Abstract Background In posterior cortical atrophy (PCA, there is a progressive impairment of high-level visual functions and parietal damage, which might predict the occurrence of visual neglect. However, neglect may pass undetected if not assessed with specific tests, and might therefore be underestimated in PCA. In this prospective study, we aimed at establishing the side, the frequency and the severity of visual neglect, visual extinction, and primary visual field defects in an unselected sample of PCA patients. Methods Twenty-four right-handed PCA patients underwent a standardized battery of neglect tests. Visual fields were examined clinically by the confrontation method. Results Sixteen of the 24 patients (66% had signs of visual neglect on at least one test, and fourteen (58% also had visual extinction or hemianopia. Five patients (21% had neither neglect nor visual field defects. As expected, left-sided neglect was more severe than right-sided neglect. However, right-sided neglect resulted more frequently in this population (29% than in previous studies on focal brain lesions. Conclusion When assessed with specific visuospatial tests, visual neglect is frequent in patients with PCA. Diagnosis of neglect is important because of its negative impact on daily activities. Clinicians should consider the routine use of neglect tests to screen patients with high-level visual deficits. The relatively high frequency of right-sided neglect in neurodegenerative patients supports the hypothesis that bilateral brain damage is necessary for right-sided neglect signs to occur, perhaps because of the presence in the right hemisphere of crucial structures whose damage contributes to neglect.

  13. Child neglect identification: The health visitor's role.

    Science.gov (United States)

    Akehurst, Rachel

    2015-11-01

    Child neglect is a significant public health issue, with impact often persisting into adulthood. However, neglect is not easily identifiable and may go undetected for many years. This library-based literature review critically analyses the research to uncover effective practices to aid neglect identification. The literature identifies that professionals may observe particular risk factors in a child's life that make neglect more probable. Additionally, children who suffer neglect, and parents who neglect their children, may display signs that practitioners can be alert to. However, a number of barriers exist that make identification difficult. The literature highlights that health visitors have a significant role to play in identifying neglect. Final conclusions relate to the need for professional supervision, use of assessment tools and frameworks, multi-agency training, and timely interventions to safeguard children.

  14. Human Echinococcosis: A Neglected Disease

    Directory of Open Access Journals (Sweden)

    António Menezes da Silva

    2010-01-01

    Full Text Available Echinococcosis is among the most neglected parasitic diseases. Development of new drugs and other treatment modalities receives very little attention, if any. In most developed countries, Cystic Echinococcosis (CE is an imported disease of very low incidence and prevalence and is found almost exclusively in migrants from endemic regions. In endemic regions, predominantly settings with limited resources, patient numbers are high. Whole communities do not have access to appropriate treatment. The choice of treatment modalities is limited because of poor infrastructure and shortage of equipment and drugs. In this context, CE meets the criteria for a neglected disease. Furthermore, the terminology related to the designations around the parasite, its evolution and some therapeutic procedures is not uniform and sometimes inappropriate terms and wrong designations are used based on incorrect concepts. Although all of us know the different aspects of the disease it is pertinent to remember some important points and, above all, to clarify some aspects concerning the hydatid cyst's nomenclature in order to understand better the therapeutic options in the liver locations, particularly the different surgical approaches.

  15. Free-range pigs foraging on Jerusalem artichokes (Helianthus tuberosus L.) – Effect of feeding strategy on growth, feed conversion and animal behaviour

    DEFF Research Database (Denmark)

    Kongsted, Anne Grete; Horsted, Klaus; Hermansen, John Erik

    2013-01-01

    The nutritional contributions from free-range foraging, growth, feed conversion and behaviour were investigated in 36 growing pigs foraging on Jerusalem artichokes (JA) and fed concentrates restrictedly (30% of energy recommendations) or ad libitum. Compared to the ad libitum fed pigs, the pigs f...

  16. Antidepressant & anxiolytic activities of N-(pyridin-3-yl quinoxalin-2-carboxamide: A novel serotonin type 3 receptor antagonist in behavioural animal models

    Directory of Open Access Journals (Sweden)

    Dilip Kumar Pandey

    2016-01-01

    Interpretation & conclusions: The present findings indicate the potential antidepressant-like and anxiolytic-like effects of QCF-21 at low doses in rodent behavioural models of depression and anxiety. Further studies need to be done to understand the underlying mechanism.

  17. Towards a Definition of Serendipity in Information Behaviour

    Science.gov (United States)

    Agarwal, Naresh Kumar

    2015-01-01

    Introduction: Serendipitous or accidental discovery of information has often been neglected in information behaviour models, which tend to focus on information seeking, a more goal-directed behaviour. Method: This theoretical paper seeks to map the conceptual space of serendipity in information behaviour and to arrive at a definition. This is done…

  18. The effect of external marking on the behaviour of the common pill woodlouse Armadillidium vulgare

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    Táňa Drahokoupilová

    2012-03-01

    Full Text Available Zoologists distinguish individual animals using marking techniques. Generally they test the potential influence of marking on survival only; the influence on behaviour is usually neglected. We evaluated the influence of two external marking techniques (nail polish and queen-bee marker on the behaviour of common pill woodlouse, Armadillidium vulgare. The behaviour was examined from two points of view: (1 activity during 24 hours and (2 specific expressions of behaviour (exploring, feeding, resting and hiding over a 24 hour period. We compared behaviour among woodlice marked with nail polish and queen-bee marker with the unmarked control group during a nine-day experiment. Although we did not find any influence of marking on survival, there was an evident influence on behaviour in most cases. Generally, in the groups of marked individuals of A. vulgare there were large differences observed against the control group in the overall activity. Activity of marked individuals was significantly reduced and they preferred hiding. The influence of polish and marker on the overall frequencies of behavioural categories was evident, mainly in feeding, resting and hiding. The influence on the frequency of exploring was significant in the polish marked group only.

  19. Definition, Measuring and Prevalence of Child Neglect

    DEFF Research Database (Denmark)

    Christensen, Else

    group, although at least four per cent of all children under one year of age, is subjected to child abuse and neglect. In her study, Else Christensen has attempted to estimate the extent of the problem among children under the age of one year. Furthermose, she has made a theoetical and practical...... clarification of the concept child abuse and neglect. Excatly which signs is the health nurse to observe in order to employ the serious term child abuse and neglect?...

  20. The Predictive Nature of Pseudoneglect for Visual Neglect: Evidence from Parietal Theta Burst Stimulation.

    Directory of Open Access Journals (Sweden)

    Alice Varnava

    Full Text Available Following parietal damage most patients with visual neglect bisect horizontal lines significantly away from the true centre. Neurologically intact individuals also misbisect lines; a phenomenon referred to as 'pseudoneglect'. In this study we examined the relationship between neglect and pseudoneglect by testing how patterns of pre-existing visuospatial asymmetry predict asymmetry caused by parietal interference. Twenty-four participants completed line bisection and Landmark tasks before receiving continuous theta burst stimulation to the left or right angular gyrus. Results showed that a pre-existing pattern of left pseudoneglect (i.e. right bias, but not right pseudoneglect, predicts left neglect-like behaviour during line bisection following right parietal cTBS. This correlation is consistent with the view that neglect and pseudoneglect arise via a common or linked neural mechanism.

  1. Galvanic Vestibular Stimulation in Hemi-Spatial Neglect

    Directory of Open Access Journals (Sweden)

    David eWilkinson

    2014-01-01

    Full Text Available Hemi-spatial neglect is an attentional disorder in which the sufferer fails to acknowledge or respond to stimuli appearing in contralesional space. In recent years, it has become clear that a measurable reduction in contralesional neglect can occur during galvanic vestibular stimulation, a technique by which transmastoid, small amplitude current induces lateral, attentional shifts via asymmetric modulation of the left and right vestibular nerves. However, it remains unclear whether this reduction persists after stimulation is stopped. To estimate longevity of effect, we therefore conducted a double-blind, randomized, dose-response trial involving a group of stroke patients suffering from left-sided neglect (n=52, mean age=66 years. To determine whether repeated sessions of galvanic vestibular stimulation more effectively induce lasting relief than a single session, participants received 1, 5, or 10 sessions, each lasting 25mins, of sub-sensory, left-anodal right-cathodal noisy direct current (mean amplitude=1mA. Ninety five percent confidence intervals indicated that all three treatment arms showed a statistically significant improvement between the pre-stimulation baseline and the final day of stimulation on the primary outcome measure, the conventional tests of the Behavioural Inattention Test. More remarkably, this change (mean change=28%, SD=18 was still evident 1month later. Secondary analyses indicated an allied increase of 20% in median Barthel Index score, a measure of functional capacity, in the absence of any adverse events or instances of participant non-compliance. Together these data suggest that galvanic vestibular stimulation, a simple, cheap technique suitable for home-based administration, may produce lasting reductions in neglect that are clinically important. Further protocol optimization is now needed ahead of a larger effectiveness study.

  2. Novel insights in the rehabilitation of neglect

    NARCIS (Netherlands)

    Kessel, M.E. van; Fasotti, L.

    2013-01-01

    Visuospatial neglect due to right hemisphere damage, usually a stroke, is a major cause of disability, impairing the ability to perform a whole range of everyday life activities. Conventional and long-established methods for the rehabilitation of neglect like visual scanning training, optokinetic st

  3. Child Dental Neglect: A Short Review

    Science.gov (United States)

    Ramazani, Nahid

    2014-01-01

    Context: Child dental neglect is a terrible tragedy with a high prevalence. Dealing with this issue is important regarding psychological and physical health policies. The current review was conducted to provide health professionals insight into the different aspects of child dental neglect as reported in previous literature. Evidence Acquisition: Our review was prepared through an electronic search using Pub Med, Science Direct, Medline, Google, Cochran Library, Google Scholar and EMBASE databases. Relevant papers published since 2000 until now in English, discussing child dental neglect were retrieved. Both original and review papers were included. Eligible articles were fully read by the author. A data form was used to record useful findings. Results: Distinguishing the direct and indirect signs of dental neglect is the first step for improvement of this matter. The dental team are the main professionals who can improve parental knowledge about the consequences of child dental neglect. Victims suffer from short and long-term adverse outcomes. Collaborative attempts need to be made by different health professionals to deal with this problem. Conclusions: Child dental neglect has many long-term impacts. The main professionals who are responsible for identification, intervention and treatment of child dental neglect are dental practitioners. However, other professionals cannot ignore this task. Finally, child dental neglect, despite its derivative outcomes, may be a presentation of a broader maltreatment. PMID:25741483

  4. Trypanosomatid parasites causing neglected diseases.

    Science.gov (United States)

    Nussbaum, K; Honek, J; Cadmus, C M C v C; Efferth, T

    2010-01-01

    Parasitic diseases such as Kala azar (visceral leishmaniasis), Chagas disease human (American trypanosomiasis) and African sleeping sickness (African trypanosomiasis) are affecting more than 27 million people worldwide. They are categorized amongst the most important neglected diseases causing approximately 150,000 deaths annually. As no vaccination is available, treatment is solely dependent on chemotherapeutic drugs. This review provides a comprehensive insight into the treatment of Kala azar, Chagas disease and African sleeping sickness. In addition to established drugs, novel small molecule- based therapeutic approaches are discussed. Drugs currently used for the treatment of Kala azar include pentavalent antimonials, Amphotericin B, Miltefosine, and Paromomycin. Liposomal formulations such as AmBisome provide promising alternatives. Furthermore, antiproliferative compounds might open new avenues in Kala azar treatment. Regarding Chagas disease, chemotherapy is based on two drugs, Nifurtimox and Benznidazole. However, sequencing of T. cruzi genome in the year 2005 raises a hope for new drug targets. Proteases, sterols and sialic acids are potential promising drug targets. Suramin, Pentamidine, Melarsporol and Eflornithine are well-established drugs to treat African sleeping sickness. New treatment options include combination therapy of Eflornithine and Nifurtimox, a Chagas disease therapeutic.. However, all approved chemotherapeutic compounds for trypanosomatid diseases suffer from high toxicity. Further, increasing resistance limits their efficacy and compliance.

  5. Liver Flukes: the Malady Neglected

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Jae Hoon [Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)

    2011-06-15

    Liver fluke disease is a chronic parasitic inflammatory disease of the bile ducts. Infection occurs through ingestion of fluke-infested, fresh-water raw fish. The most well-known species that cause human infection are Clonorchis sinensis, Opisthorchis viverrini and Opisthorchis felineus. Adult flukes settle in the small intrahepatic bile ducts and then they live there for 20-30 years. The long-lived flukes cause long-lasting chronic inflammation of the bile ducts and this produces epithelial hyperplasia, periductal fibrosis and bile duct dilatation. The vast majority of patients are asymptomatic, but the patients with heavy infection suffer from lassitude and nonspecific abdominal complaints. The complications are stone formation, recurrent pyogenic cholangitis and cholangiocarcinoma. Approximately 35 million people are infected with liver flukes throughout the world and the exceptionally high incidence of cholangiocarcinoma in some endemic areas is closely related with a high prevalence of liver fluke infection. Considering the impact of this food-borne malady on public health and the severe possible clinical consequences, liver fluke infection should not be forgotten or neglected.

  6. An introduction to neglected disasters

    Directory of Open Access Journals (Sweden)

    Ben Wisner

    2009-04-01

    Full Text Available This theme issue of Jàmbá takes up the question of neglected disasters. It is an important topic because the world is changing, disasters are changing, and theory is changing. All these changes call for a re-assessment of why some human suffering and social disruption receive attention from authorities, donors, researchers and the media, while some does not. Recent progress in both development studies and disaster studies provides tools for answering this question. Development and disaster studies date in their current forms to ways of thinking that were current in academic and policy circles in the late 1950s and 1960s. At that time the world was recovering from world war and former colonies of Europe were gaining independence. It was a world in which (with some exceptions conflict was held in check in an uneasy cold war balance. It was also a world where a growing UN system held the promise of meeting humanitarian needs when they arose. That world is no more. ‘Development’ has changed.

  7. Behavioural social choice: a status report.

    Science.gov (United States)

    Regenwetter, Michel; Grofman, Bernard; Popova, Anna; Messner, William; Davis-Stober, Clintin P; Cavagnaro, Daniel R

    2009-03-27

    Behavioural social choice has been proposed as a social choice parallel to seminal developments in other decision sciences, such as behavioural decision theory, behavioural economics, behavioural finance and behavioural game theory. Behavioural paradigms compare how rational actors should make certain types of decisions with how real decision makers behave empirically. We highlight that important theoretical predictions in social choice theory change dramatically under even minute violations of standard assumptions. Empirical data violate those critical assumptions. We argue that the nature of preference distributions in electorates is ultimately an empirical question, which social choice theory has often neglected. We also emphasize important insights for research on decision making by individuals. When researchers aggregate individual choice behaviour in laboratory experiments to report summary statistics, they are implicitly applying social choice rules. Thus, they should be aware of the potential for aggregation paradoxes. We hypothesize that such problems may substantially mar the conclusions of a number of (sometimes seminal) papers in behavioural decision research.

  8. Prisms and neglect: what have we learned?

    Science.gov (United States)

    Newport, Roger; Schenk, Thomas

    2012-05-01

    Since Rossetti et al. (1998) reported that prism adaptation (PA) can lead to a substantial reduction of neglect symptoms PA has become a hot topic in neglect-research. More than 280 articles have been published in this area. Not all of those studies investigated the therapeutic potential of this technique, many studies examined the responsiveness to PA as a way to subdivide neglect into separate subsyndromes, other studies focussed on the process of PA itself in an effort to illuminate its underlying neurobiological mechanisms. In this article we will review research in all of these three areas to determine whether and to what extent research on PA in neglect patients has fulfilled its promise as a new way to improve the treatment of neglect, enhance our understanding of this complex syndrome and provide new insights into the neurobiology of sensorimotor learning.

  9. Disruptions to number bisection after brain injury: Neglecting parts of the Mental Number Line or working memory impairments?

    Science.gov (United States)

    Storer, Lauren; Demeyere, Nele

    2014-04-01

    The aim of this study was to investigate the mechanisms underlying consistent directional number bisection bias in a chronic neuropsychological sample, not selected based on behaviour or lesion definitions. Patients completed a test battery that included measures of number bisection, line bisection, verbal working memory, visual-spatial working memory, egocentric neglect and allocentric neglect. Neither the neglect nor working memory measures were found to significantly correlate with number bisection. Furthermore, when outlier patients with very distinct number bisection biases were compared to patients who did not show any number bisection difficulties, no differences were found between the two groups on any of the other behavioural measures. We conclude that number bisection difficulties are not consistently based on any single deficit, be it neglect or working memory, and biases in number bisection should not be assumed to directly reflect problems in either of these areas.

  10. Brain responses to detection of right or left somatic targets are symmetrical in unilateral Parkinson's disease: a case against the concept of "parkinsonian neglect'.

    Science.gov (United States)

    García-Larrea, L; Brousolle, E; Gravejat, M F; Chazot, G; Mauguière, F

    1996-12-01

    Signs of attentional dysfunction mimicking spatial neglect have been described both in humans with lateralised Parkinson's Disease (PD) and in animals with MPTP-related hemiparkinsonism. Such deficits have been attributed to dopamine loss in basal ganglia and cortical targets. However, in previous studies the existence of neglect was assumed from behavioural tests which needed a motor output, thus entailing interpretation ambiguities due to effects of directional hypokinesia. We recorded brain event-related potentials (ERPs) evoked by the presentation of target somatic stimuli to the affected and non-affected sides in 44 patients with unilateral or asymmetrical PD. The N2 and P3 ERP components were specifically analysed, since (a) they are triggered selectively by task-relevant, attended sensory stimuli; (b) their latency reflects stimulus evaluation time, independently from the execution of a motor response, and (c) they have proved to be abnormal in hemineglect syndromes due to focal brain lesions. Irrespective of the side (left or right) of motor symptom predominance there were no significant ERP differences to stimulation of the affected and non-affected limbs, nor was there any correlation between ERP latencies and the degree of dopamine-related motor impairment. The P3 latency was abnormally delayed in 23% of the patients, but there was no trend for abnormalities to concentrate on the affected side. This study does not confirm the existence of a significant attentional impairment toward the affected limb in lateralised PD, and suggests that previous clinical evidence of "neglect' behaviour in PD might be linked to directional hypokinesia, thus reflecting intentional, rather than attentional lateralised deficits.

  11. Current pipelines for neglected diseases.

    Directory of Open Access Journals (Sweden)

    Paolo di Procolo

    2014-09-01

    Full Text Available This paper scrutinises pipelines for Neglected Diseases (NDs, through freely accessible and at-least-weekly updated trials databases. It updates to 2012 data provided by recent publications, and integrates these analyses with information on location of trials coordinators and patients recruitment status. Additionally, it provides (i disease-specific information to better understand the rational of investments in NDs, (ii yearly data, to understand the investment trends. The search identified 650 clinical studies. Leishmaniasis, Arbovirus infection, and Dengue are the top three diseases by number of clinical studies. Disease diffusion risk seems to be the most important driver of the clinical trials target choice, whereas the role played by disease prevalence and unmet need is controversial. Number of trials is stable between 2005 and 2010, with an increase in the last two years. Patient recruitment was completed for most studies (57.6%, and Phases II and III account for 35% and 28% of trials, respectively. The primary purpose of clinical investigations is prevention (49.3%, especially for infectious diseases with mosquitoes and sand flies as the vector, and treatment (43.2%, which is the primary target for parasitic diseases Research centres and public organisations are the most important clinical studies sponsors (58.9%, followed by the pharmaceutical industry (24.1%, foundations and non-governmental organisations (9.3%. Many coordinator centres are located in less affluent countries (43.7%, whereas OECD countries and BRICS account for 34.7% and 17.5% of trials, respectively. Information was partially missing for some parameters. Notwithstanding, and despite its descriptive nature, this research has enhanced the evidence of the literature on pipelines for NDs. Future contributions may further investigate whether trials metrics are consistent with the characteristics of the interested countries and the explicative variables of trials location

  12. Current pipelines for neglected diseases.

    Science.gov (United States)

    di Procolo, Paolo; Jommi, Claudio

    2014-09-01

    This paper scrutinises pipelines for Neglected Diseases (NDs), through freely accessible and at-least-weekly updated trials databases. It updates to 2012 data provided by recent publications, and integrates these analyses with information on location of trials coordinators and patients recruitment status. Additionally, it provides (i) disease-specific information to better understand the rational of investments in NDs, (ii) yearly data, to understand the investment trends. The search identified 650 clinical studies. Leishmaniasis, Arbovirus infection, and Dengue are the top three diseases by number of clinical studies. Disease diffusion risk seems to be the most important driver of the clinical trials target choice, whereas the role played by disease prevalence and unmet need is controversial. Number of trials is stable between 2005 and 2010, with an increase in the last two years. Patient recruitment was completed for most studies (57.6%), and Phases II and III account for 35% and 28% of trials, respectively. The primary purpose of clinical investigations is prevention (49.3%), especially for infectious diseases with mosquitoes and sand flies as the vector, and treatment (43.2%), which is the primary target for parasitic diseases Research centres and public organisations are the most important clinical studies sponsors (58.9%), followed by the pharmaceutical industry (24.1%), foundations and non-governmental organisations (9.3%). Many coordinator centres are located in less affluent countries (43.7%), whereas OECD countries and BRICS account for 34.7% and 17.5% of trials, respectively. Information was partially missing for some parameters. Notwithstanding, and despite its descriptive nature, this research has enhanced the evidence of the literature on pipelines for NDs. Future contributions may further investigate whether trials metrics are consistent with the characteristics of the interested countries and the explicative variables of trials location, target

  13. Antidepressant & anxiolytic activities of N-(pyridin-3-yl) quinoxalin-2-carboxamide: A novel serotonin type 3 receptor antagonist in behavioural animal models

    Science.gov (United States)

    Pandey, Dilip Kumar; Devadoss, Thangraj; Modak, Neha; Mahesh, Radhakrishnan

    2016-01-01

    Background & objectives: Alteration in the serotonin leads to the psychological illness, such as depression, anxiety, schizophrenia, eating disorders, obsessive-compulsive disorder, panic disorders and migraines. The objective of the current study was to investigate the antidepressant and anxiolytic activities of N-(pyridin-3-yl) quinoxalin-2-carboxamide (QCF-21), a novel 5-HT3 receptor antagonist in preclinical models of depression and anxiety. Methods: Antidepressant activity was evaluated in preliminary tests such as forced swim and tail suspension tests (FST & TST). Anti-anxiety effect of QCF-21 was investigated by employing elevated plus maze (EPM), light/dark and hole board tests. Olfactory bulbectomy (OBX) in rats was used as chronic model of depression. Mechanistic test of QCF-21 was evaluated by reserpine-induced hypothermia and 5-hydroxytryptophan (5-HTP)-induced head-twitch response. Results: The dose-response study revealed an initial antidepressant-like effect of QCF-21(0.25-1 mg/kg, i.p.) in the FST and TST and anxiolytic-like effect in EPM, light and dark and hole board tests. QCF-21 potentiated the 5-HTP-induced head-twitches response in mice and reversed reserpine-induced hypothermia in rats. QCF-21 significantly reversed the behavioural anomalies post-OBX in rats. Interpretation & conclusions: The present findings indicate the potential antidepressant-like and anxiolytic-like effects of QCF-21 at low doses in rodent behavioural models of depression and anxiety. Further studies need to be done to understand the underlying mechanism. PMID:28256473

  14. Dental neglect among children in Chennai

    Directory of Open Access Journals (Sweden)

    Deepa Gurunathan

    2016-01-01

    Full Text Available Background: Child dental neglect is the failure of a parent or guardian to meet the child′s basic oral health needs such that the child enjoys adequate function and freedom from pain and infection, where reasonable resources are available to family or caregiver. Aim: The aim of the study is to evaluate the phenomenon of dental neglect among children in Chennai and to associate dental neglect with oral health status of children aged 3-12 years. Materials and Methods: This is a cross-sectional study involving 478 pairs of parents and children. Dental neglect scale and a questionnaire were used to assess the dental neglect score among parents of the children involved in the study. Oral health status of children was clinically assessed using oral hygiene index, decayed, extracted, filled teeth (def(t, pulp, ulcers, fistula, abscess (pufa, decayed, missing, filled teeth (DMFT, PUFA as per the World Health Organization criteria and pufa/PUFA index. Student′s t-test and one-way ANOVA were used appropriately for statistical analysis using SPSS software version 20.0. Results: A significant higher dental neglect score was reported among the parents who reside in the suburban location (P 3 years (P = 0.001. A significant higher DMFT (P = 0.003, deft (P = 0 < 0.001, pufa (P = 0.011, and debris index (P = 0.002 scores were seen in the higher dental neglect group. Conclusion: Child dental neglect is seen among the parents whose educational qualification was secondary, who reside in the suburban location, and who have not utilized the dental services for more than 3 years in Chennai. This dental neglect results in poorer oral health of children.

  15. Bienestar Animal: Comportamiento productivo y salud de las crías de cerdos alojadas en tecnología Flat Deck - Animal Well-being: Productive behaviour and health of the breeding of pigs housed in technology Flat Deck

    OpenAIRE

    Maikel Díaz Gutierrez; Yunier Hernández Cruz

    2010-01-01

    ResumenCon el objetivo de evaluar comportamiento productivo y de salud de las crías de cerdos alojados en tecnología Flat Deck se realiza el trabajo Bienestar Animal: Comportamiento productivo y de salud de las crías de cerdos alojadas en tecnología Flat Deck. Para ello se utilizaron 24 bóxer de maternidad de tecnología Flat Deck, de estos 12 de origen chino y 12 de origen español con características similares. Se analizaron un total de 1433 crías mestizas (cruce de hembras Yorkland entre la ...

  16. Is There a Place for Ipsilesional Eye Patching in Neglect Rehabilitation?

    Directory of Open Access Journals (Sweden)

    N. Soroker

    1994-01-01

    Full Text Available Neglect behavior of experimental animals with unilateral posterior cortical lesions improves with the placement of a second lesion in the contralesional superior colliculus or in the intercollicular commissure. Given that the retinotectal fibers are mainly crossed, it has been speculated that ipsilesional eye patching, by depriving the contralesional superior colliculus of its main facilitatory visual input, might achieve similar results, and thus be used as a remediation maneuver in patients with neglect. From six patients with severe persistent neglect, only one showed an unequivocal beneficial effect from ipsilesional eye patching. We discuss the factors which possibly underlie success and failure with this procedure, and the place for it in neglect rehabilitation.

  17. Ecological implications of behavioural syndromes.

    Science.gov (United States)

    Sih, Andrew; Cote, Julien; Evans, Mara; Fogarty, Sean; Pruitt, Jonathan

    2012-03-01

    Interspecific trait variation has long served as a conceptual foundation for our understanding of ecological patterns and dynamics. In particular, ecologists recognise the important role that animal behaviour plays in shaping ecological processes. An emerging area of interest in animal behaviour, the study of behavioural syndromes (animal personalities) considers how limited behavioural plasticity, as well as behavioural correlations affects an individual's fitness in diverse ecological contexts. In this article we explore how insights from the concept and study of behavioural syndromes provide fresh understanding of major issues in population ecology. We identify several general mechanisms for how population ecology phenomena can be influenced by a species or population's average behavioural type, by within-species variation in behavioural type, or by behavioural correlations across time or across ecological contexts. We note, in particular, the importance of behavioural type-dependent dispersal in spatial ecology. We then review recent literature and provide new syntheses for how these general mechanisms produce novel insights on five major issues in population ecology: (1) limits to species' distribution and abundance; (2) species interactions; (3) population dynamics; (4) relative responses to human-induced rapid environmental change; and (5) ecological invasions.

  18. Animal transportation networks.

    Science.gov (United States)

    Perna, Andrea; Latty, Tanya

    2014-11-01

    Many group-living animals construct transportation networks of trails, galleries and burrows by modifying the environment to facilitate faster, safer or more efficient movement. Animal transportation networks can have direct influences on the fitness of individuals, whereas the shape and structure of transportation networks can influence community dynamics by facilitating contacts between different individuals and species. In this review, we discuss three key areas in the study of animal transportation networks: the topological properties of networks, network morphogenesis and growth, and the behaviour of network users. We present a brief primer on elements of network theory, and then discuss the different ways in which animal groups deal with the fundamental trade-off between the competing network properties of travel efficiency, robustness and infrastructure cost. We consider how the behaviour of network users can impact network efficiency, and call for studies that integrate both network topology and user behaviour. We finish with a prospectus for future research.

  19. Observational measure of elder self-neglect.

    Science.gov (United States)

    Iris, Madelyn; Conrad, Kendon J; Ridings, John

    2014-01-01

    The purpose of this study was to improve measurement of elder self-neglect by testing the psychometric properties of the Elder Self-Neglect Assessment (ESNA). Social workers, case managers, and adult protective services providers from 13 Illinois agencies completed a 77-item assessment for 215 clients suffering from self neglect. Analyses used Rasch item response theory and traditional validation approaches to test for dimensionality, model fit, and additional construct validation, resulting in a 62-item assessment. The ESNA met Rasch fit criteria with good internal consistency, item reliability, and construct validity. A 25-item short form also met Rasch criteria. A hierarchy of items associated with severity of abuse was produced by frequency of occurrence. ESNA indicators of self-neglect align into two broad categories: behavioral characteristics and environmental factors, which must be accounted for in a comprehensive evaluation. Theoretical refinements developed using the empirically generated item hierarchy may help to improve assessment and intervention.

  20. Therapeutics for Rare and Neglected Diseases

    Data.gov (United States)

    Federal Laboratory Consortium — There are more than 6,500 identified rare and neglected diseases, yet only about 250 treatments are available for these conditions. The limited numbers of patients...

  1. Neglect of Solid State Chemistry Scored

    Science.gov (United States)

    Chemical and Engineering News, 1974

    1974-01-01

    At a recent symposium concerning the teaching of solid state chemistry in the classroom, many educators indicated that important areas of solid state chemistry were being neglected in college curricula. (RH)

  2. An empiricist guide to animal personality variation in ecology and evolution

    Directory of Open Access Journals (Sweden)

    Sasha R.X. Dall

    2014-02-01

    Full Text Available The study of animal personality variation promises to provide significant new insight into the way that behaviour evolves in animals, along with its ecological and evolutionary influences. We strongly advocate more empirical work in this exciting and rapidly expanding research area, but hope that new studies adopt a more hypothesis-driven and/or experimental approach than seems to be usual at the moment. Here we outline what we feel is good practice to the many empiricists that are keen on pursuing work in this field. We highlight the substantial body of theoretical work that exists for providing well-reasoned hypotheses, which new empirical studies should be designed to test. Furthermore, using a brief review of existing work on the behavioural ecology of animal personality variation in the zebra finch - one of the more widely used model systems in this field - we stress the importance of understanding the ecology of the chosen study animal, and the problems that are likely to arise by neglecting to identify or account for the structure of behavioural variation that is often likely to occur.

  3. Motivational control of sign-tracking behaviour: A theoretical framework.

    Science.gov (United States)

    Anselme, Patrick

    2016-06-01

    Learning and motivation are two psychological processes allowing animals to form and express Pavlovian associations between a conditioned stimulus (CS) and an unconditioned stimulus (UCS). However, most models have attempted to capture the mechanisms of learning while neglecting the role that motivation (or incentive salience) may actively play in the expression of behaviour. There is now a body of neurobehavioural evidence showing that incentive salience represents a major determinant of Pavlovian performance. This article presents a motivational model of sign-tracking behaviour whose aim is to explain a wide range of behavioural effects, including those related to partial reinforcement, physiological changes, competition between CSs, and individual differences in responding to a CS. In this model, associative learning is assumed to determine the ability to produce a Pavlovian conditioned response rather than to control the strength and the quality of that response. The model is in keeping with the incentive salience hypothesis and will therefore be discussed in the context of dopamine's role in the brain.

  4. Using movement behaviour to define biological seasons for woodland caribou

    Directory of Open Access Journals (Sweden)

    Tyler D. Rudolph

    2012-03-01

    Full Text Available Terrestrial mammals are strongly influenced by seasonal changes in environmental conditions. Studies of animal space use behaviour are therefore inherently seasonal in nature. We propose an individual-based quantitative method for identifying seasonal shifts in caribou movement behaviour and we demonstrate its use in determining the onset of the winter, spring dispersal, and calving seasons. Using pooled data for the population we demonstrate an alternate approach using polynomial regression with mixed effects. We then compare individual onset dates with population-based estimates and those adopted by expert consensus for our study area. Distributions of individual-based onset dates were normally distributed with prominent modes; however, there was considerable variation in individual onset times. Population-based estimates were closer to the peaks of individual estimates than were expert-based estimates, which fell outside the onetailed 90% and 95% sample quantiles of individually-fitted distributions for spring and winter, respectively. Both expertand population-based estimates were later for winter and earlier for both spring and calving than were individual-based estimates. We discuss the potential consequences of neglecting to corroborate conventionally used dates with observed seasonal trends in movement behaviour. In closing, we recommend researchers adopt an individual-based quantitative approach and a variable temporal window for data set extraction.

  5. Breeding for behavioural change in farm animails

    DEFF Research Database (Denmark)

    Sandøe, Peter; D'eath, RB; Lawrence, AB

    2009-01-01

    examples, such as breeding for good maternal behaviour, could enhance welfare, production and naturalness, although dilemmas emerge where improved welfare could result from breeding away from natural behaviour. Selection against certain behaviours may carry a risk of creating animals which are generally......In farm animal breeding, behavioural traits are rarely included in selection programmes despite their potential to improve animal production and welfare. Breeding goals have been broadened beyond production traits in most farm animal species to include health and functional traits......, and opportunities exist to increase the inclusion of behaviour in breeding indices. On a technical level, breeding for behaviour presents a number of particular challenges compared to physical traits. It is much more difficult and time-consuming to directly measure behaviour in a consistent and reliable manner...

  6. Novel insights in the rehabilitation of neglect.

    Science.gov (United States)

    Fasotti, Luciano; van Kessel, Marlies

    2013-11-15

    Visuospatial neglect due to right hemisphere damage, usually a stroke, is a major cause of disability, impairing the ability to perform a whole range of everyday life activities. Conventional and long-established methods for the rehabilitation of neglect like visual scanning training, optokinetic stimulation, or limb activation training have produced positive results, with varying degrees of generalization to (un)trained tasks, lasting from several minutes up to various months after training. Nevertheless, some promising novel approaches to the remediation of left visuospatial neglect have emerged in the last decade. These new therapy methods can be broadly classified into four categories. First, non-invasive brain stimulation techniques by means of transcranial magnetic stimulation (TMS) or transcranial direct current stimulation (tDCS), after a period of mainly diagnostic utilization, are increasingly applied as neurorehabilitative tools. Second, two classes of drugs, dopaminergic and noradrenergic, have been investigated for their potential effectiveness in rehabilitating neglect. Third, prism adaptation treatment has been shown to improve several neglect symptoms consistently, sometimes during longer periods of time. Finally, virtual reality technologies hold new opportunities for the development of effective training techniques for neglect. They provide realistic, rich, and highly controllable training environments. In this paper the degree of effectiveness and the evidence gathered to support the therapeutic claims of these new approaches is reviewed and discussed. The conclusion is that for all these approaches there still is insufficient unbiased evidence to support their effectiveness. Further neglect rehabilitation research should focus on the maintenance of therapy results over time, on a more functional evaluation of treatment effects, on the design and execution of true replication studies and on the exploration of optimal combinations of treatments.

  7. Novel insights in the rehabilitation of neglect.

    Directory of Open Access Journals (Sweden)

    Luciano eFasotti

    2013-11-01

    Full Text Available Visuospatial neglect due to right hemisphere damage, usually a stroke, is a major cause of disability, impairing the ability to perform a whole range of everyday life activities. Conventional and long-established methods for the rehabilitation of neglect like visual scanning training, optokinetic stimulation or limb activation training have produced positive results, with varying degrees of generalisation to (untrained tasks lasting from several minutes up to various months after training. Nevertheless, some promising novel approaches to the remediation of left visuo-spatial neglect have emerged in the last decade. These new therapy methods can be broadly classified into 4 categories. First, non-invasive brain stimulation techniques by means of transcranial magnetic stimulation (TMS or transcranial direct current stimulation (tDCS, after a period of mainly diagnostic utilization, are increasingly applied as neurorehabilitative tools. Second, two classes of drugs, dopaminergic and noradrenergic, have been investigated for their potential effectiveness in rehabilitating neglect. Third, prism adaptation treatment has been shown to improve several neglect symptoms consistently, sometimes during longer periods of time. Finally, virtual reality technologies hold new opportunities for the development of effective training techniques for neglect. They provide realistic, rich and highly controllable training environments. In this paper the degree of effectiveness and the evidence gathered to support the therapeutic claims of these new approaches is reviewed and discussed. The conclusion is that for all these approaches there still is insufficient unbiased evidence to support their effectiveness. Further neglect rehabilitation research should focus on the maintenance of therapy results over time, on a more functional evaluation of treatment effects, on the design and execution of true replication studies and on the exploration of optimal combinations of

  8. Meta-analysis on the effects of the physical environment, animal traits, feeder and feed characteristics on the feeding behaviour and performance of growing-finishing pigs.

    Science.gov (United States)

    Averós, X; Brossard, L; Dourmad, J Y; de Greef, K H; Edwards, S A; Meunier-Salaün, M C

    2012-08-01

    A meta-analysis, using information from 45 experiments on growing-finishing pigs published in 39 manuscripts, was carried out to determine the simultaneous effects of the physical environment (space allowance, group size, flooring conditions, temperature, presence of enrichment), pig traits (initial body weight (BW) for each studied time interval, sex, genetics), feeder characteristics (water provision within the feeder, feeder design (individual/collective), feeder places/pig, presence of feeder protection) and feed characteristics (feed allowance (ad libitum/restricted), net energy content, crude protein (CP) content), as well as their potential interactions, on the feeding behaviour and performance of growing-finishing pigs. The detrimental effect of low temperature on performance was particularly evident for restricted-fed pigs (P < 0.05). At reduced feeder space allowance, a reduction in the percentage of time spent eating was predicted when increasing initial BW, whereas the opposite was predicted for larger feeder space allowances (P < 0.001). The reduction in visit duration to the feeder in higher BW groups became gradually more important with increasing feeder space allowance (P < 0.01), whereas the increase in the ingestion rate and average daily feed intake (ADFI) with increasing initial BW became smaller with increasing feeder space (P < 0.05). The model predicted a reduction in feed conversion ratio (FCR) with increasing group size (P < 0.05) and floor space allowance (P < 0.01) and on solid floors with or without bedding (P < 0.05). In comparison with other feeders, wet/dry feeders were associated with more frequent but shorter feeder visits (P < 0.05), higher ingestion rates (P < 0.001) and higher ADFI (P < 0.10). The use of protection within individual feeders increased the time spent feeding (P < 0.001), reduced the number of visits per day (P < 0.01), the ingestion rate (P < 0.001) and FCR (P < 0.01) in comparison with other feeder types. Sex

  9. Behavioural consistency and life history of Rana dalmatina tadpoles

    OpenAIRE

    Urszán, Tamás Janós; Török, János; Hettyey, Attila; Garamszegi, László Z; Herczeg, Gábor

    2015-01-01

    The focus of evolutionary behavioural ecologists has recently turned towards understanding the causes and consequences of behavioural consistency, manifesting either as animal personality (consistency in a single behaviour) or behavioural syndrome (consistency across more behaviours). Behavioural type (mean individual behaviour) has been linked to life-history strategies, leading to the emergence of the integrated pace-of-life syndrome (POLS) theory. Using Rana dalmatina tadpoles as models, w...

  10. Disease behaviours of sows naturally infected with Taenia solium in Tanzania.

    Science.gov (United States)

    Trevisan, Chiara; Johansen, Maria Vang; Mkupasi, Ernatus Martin; Ngowi, Helena Aminel; Forkman, Björn

    2017-02-15

    Neurocysticercosis (NCC) is a disease caused by the zoonotic parasite Taenia solium lodging in the central nervous system. Both humans and pigs can get NCC. The impact of the disease in pigs has so far been little explored. The aim of this study was to describe the effect of NCC on social and feeding behaviours as well as the pattern of activity as indicators of reduced welfare in naturally infected sows. In total 13 T. solium naturally infected and 15 non-infected control sows were videotaped for 2 consecutive weeks using close circuit television cameras at research facilities at Sokoine University of Agriculture, Morogoro, Tanzania. Videos were analysed at the beginning, in the middle and at the end of the 2 week recording period. For each time point, videos were analysed during feeding, while the enrichment was provided, and by recording every half an hour the sows' behaviours performed over the course of a whole day. Sows with NCC spent significantly less time at the feeding trough, especially during the second half of the feeding period. Infected sows were also more passive e.g. lying and standing still significantly more during a whole day period and showed social isolation compared to non-infected control sows by performing behaviours more distant to their nearest neighbour. Results of this study indicated that NCC changed the behaviour of infected sows. The behavioural changes are indicative of decreased welfare. Efforts to reinforce the animal welfare aspect are needed as this has so far been neglected.

  11. Neglect's perspective on the Ponzo illusion.

    Science.gov (United States)

    Sedda, A; Ferrè, E R; Striemer, C L; Bottini, G

    2013-06-01

    Visual illusions have been used to explore implicit perception in neglect. Previous studies have highlighted differences between length and surface illusion perception in neglect, but much less is known about depth illusion perception. In the Ponzo illusion (a classic depth illusion), two converging oblique lines modulate the perceived length of two horizontal lines. In the current study, we presented modified versions of the Ponzo illusion in which only one of the converging oblique lines was presented (alternatively the right or the left one). This manipulation allowed us to explore (1) how acute patients with neglect process depth illusions, and (2) whether awareness of both converging lines is necessary for the full effect of the illusion. To examine these questions, we had participants (i.e. healthy controls, patients with neglect and right brain-damaged patients) to make a perceptual judgment regarding the perceived length of the upper versus lower horizontal line within the Ponzo frame in four conditions: (1) the classic Ponzo illusion, (2) a "modified left" Ponzo illusion with a single oblique line on the left, (3) a "modified right" Ponzo illusion with a single oblique line on the right and (4) a control condition with parallel lines. The results indicated that all participants perceived the canonical Ponzo illusion and the modified right illusion. Critically, patients with neglect did not perceive the modified left illusion. In addition, for neglect patients, there was no difference in the strength of the perceived illusion when comparing the canonical illusion with the modified right illusion. Importantly, single case analysis revealed a high degree of variability in the neglect group that seemed to be linked with the amount of damage to occipital areas. Overall our results indicate that: (1) the classic Ponzo illusion might be perceived in neglect patients based solely on perception of the right side of the stimulus configuration, and (2) differences

  12. Neuroimaging of eye position reveals spatial neglect.

    Science.gov (United States)

    Becker, Elisabeth; Karnath, Hans-Otto

    2010-03-01

    Conjugate eye deviation describes the tonic horizontal deviation of the eyes in acute stroke patients. Here we investigate whether measuring patients' eye-in-head position in clinical magnetic resonance imaging or computed tomography scans obtained at admission shows a specific relationship to spatial neglect. We investigated 124 continuously admitted subjects with unilateral, first-ever left- or right-sided stroke. To control for the possibility that the degree of eye deviation is related to lesion size rather than spatial neglect, overall lesion volume was used as a covariate in the statistical analysis. Horizontal eye-in-head deviation on clinical brain scans appeared to be associated with spatial neglect rather than with brain damage per se. In contrast to the subject groups without the disorder, the patients with spatial neglect showed an eye-in-head position that was significantly deviated towards the ipsilesional right. Evaluation of eye-in-head position on clinical scans thus may be an additional helpful tool for diagnosing spatial neglect, particularly in the very early period of the stroke.

  13. Simulating hemispatial neglect with virtual reality

    Directory of Open Access Journals (Sweden)

    Yoshizawa Makoto

    2007-07-01

    Full Text Available Abstract Background Hemispatial neglect is a cognitive disorder defined as a lack of attention for stimuli contra-lateral to the brain lesion. The assessment is traditionally done with basic pencil and paper tests and the rehabilitation programs are generally not well adapted. We propose a virtual reality system featuring an eye-tracking device for a better characterization of the neglect that will lead to new rehabilitation techniques. Methods This paper presents a comparison of eye-gaze patterns of healthy subjects, patients and healthy simulated patients on a virtual line bisection test. The task was also executed with a reduced visual field condition hoping that fewer stimuli would limit the neglect. Results We found that patients and healthy simulated patients had similar eye-gaze patterns. However, while the reduced visual field condition had no effect on the healthy simulated patients, it actually had a negative impact on the patients. We discuss the reasons for these differences and how they relate to the limitations of the neglect simulation. Conclusion We argue that with some improvements the technique could be used to determine the potential of new rehabilitation techniques and also help the rehabilitation staff or the patient's relatives to better understand the neglect condition.

  14. A common basis for visual and tactile exploration deficits in spatial neglect?

    Science.gov (United States)

    Schindler, Igor; Clavagnier, Simon; Karnath, Hans-Otto; Derex, Laurent; Perenin, Marie-Thérèse

    2006-01-01

    One of the fundamental characteristics of spatial neglect is an imbalanced visual search behaviour favouring stimuli on the right side of space while largely ignoring those on the left side. Opinions differ as to whether this reflects a general orientational bias caused by impaired supramodal body-centred reference systems, or a modality-specific search disorder. A prediction of the former model would be that exploratory activity is similarly impaired both in vision and in the absence of visual control. We addressed this hypothesis by comparing patients' visual and tactile search in the same workspace. Our results show that the centre of exploration activity in both modalities was substantially shifted towards the ipsilesional right side in the neglect group as compared to healthy and patient controls. This bias was more accentuated for visual search. We found a clear linear relationship between the visual and tactile search biases in the patient group with spatial neglect. Our finding suggests that the critical component guiding search behaviour in neglect, whether visually or tactually, is a general rightward orientation bias. In addition, we observed an increased repetition rate in both modalities which affected the whole workspace. This implies that the apparent spatial working memory deficit dissociates from the mechanisms inducing the orientation bias.

  15. One health - an ecological and evolutionary framework for tackling Neglected Zoonotic Diseases.

    Science.gov (United States)

    Webster, Joanne P; Gower, Charlotte M; Knowles, Sarah C L; Molyneux, David H; Fenton, Andy

    2016-02-01

    Understanding the complex population biology and transmission ecology of multihost parasites has been declared as one of the major challenges of biomedical sciences for the 21st century and the Neglected Zoonotic Diseases (NZDs) are perhaps the most neglected of all the Neglected Tropical Diseases (NTDs). Here we consider how multihost parasite transmission and evolutionary dynamics may affect the success of human and animal disease control programmes, particularly neglected diseases of the developing world. We review the different types of zoonotic interactions that occur, both ecological and evolutionary, their potential relevance for current human control activities, and make suggestions for the development of an empirical evidence base and theoretical framework to better understand and predict the outcome of such interactions. In particular, we consider whether preventive chemotherapy, the current mainstay of NTD control, can be successful without a One Health approach. Transmission within and between animal reservoirs and humans can have important ecological and evolutionary consequences, driving the evolution and establishment of drug resistance, as well as providing selective pressures for spill-over, host switching, hybridizations and introgressions between animal and human parasites. Our aim here is to highlight the importance of both elucidating disease ecology, including identifying key hosts and tailoring control effort accordingly, and understanding parasite evolution, such as precisely how infectious agents may respond and adapt to anthropogenic change. Both elements are essential if we are to alleviate disease risks from NZDs in humans, domestic animals and wildlife.

  16. Cortisol administration increases hippocampal activation to infant crying in males depending on childhood neglect

    NARCIS (Netherlands)

    Bos, P.A.; Montoya, E.R.; Terburg, D.; van Honk, J.

    2014-01-01

    Animal studies show that exposure to parental neglect alters stress regulation and can lead to neural hyposensitivity or hypersensitivity in response to cortisol, most pronounced in the hippocampus. Cortisol, the end product of the hypothalamic-pituitary-adrenal (HPA) axis, has also been related to

  17. Error Types and Error Positions in Neglect Dyslexia: Comparative Analyses in Neglect Patients and Healthy Controls

    Science.gov (United States)

    Weinzierl, Christiane; Kerkhoff, Georg; van Eimeren, Lucia; Keller, Ingo; Stenneken, Prisca

    2012-01-01

    Unilateral spatial neglect frequently involves a lateralised reading disorder, neglect dyslexia (ND). Reading of single words in ND is characterised by left-sided omissions and substitutions of letters. However, it is unclear whether the distribution of error types and positions within a word shows a unique pattern of ND when directly compared to…

  18. Identifying and Evaluating Elder Abuse and Neglect

    Directory of Open Access Journals (Sweden)

    Aygul Kissal

    2009-08-01

    Full Text Available Elder abuse and neglect have been put into agenda because of the increasing number of elderly people, changing family and socio-cultural structure, worsening of the economic conditions in recent years. Abuse and neglect has been considered as a critical and complex subject which affects the health of elderly people and their life quality. Health professionals are a central position to reveal, manage and prevent elder abuse. For this reason, They need to know the reason, risk-factor and findings of abuse. Health professionals who support elder-especially nurse- shouldn’t only deal with this subject but also they should be educated about diagnosing, reporting and attempting. This paper’s aim is to inform people about the evaluation of risk-factors, findings and prevention of elder abuse and neglect and to increase sensitivity. [TAF Prev Med Bull 2009; 8(4.000: 357-364

  19. Antidepressant Effect of Water Decoction of Rhizoma Acori Tatarinowii in the Behavioural Despair Animal Models of Depression%石菖蒲对行为绝望动物抑郁模型的抗抑郁作用

    Institute of Scientific and Technical Information of China (English)

    李明亚; 陈红梅

    2001-01-01

    Object:To assess the antidepressant effect of the water decoctionof Rhizoma acori tatarinowii.Methods: By using the rat forced swimming test and mouse tail suispension test models of depression, the antidepressant effect of Rhizoma acori tatarinowii was observed. Results: The water decoction of Rhizoma acori tatarinowii and Fluoxetine significantly shortened motionless time of rat forced swimming and despair time of mouse tail suspension in the two behavioural despair animal models of depression. Antidepressant effect of water decoction of Rhizoma acori tatarinowii showed cdose-dependence in the certain degree. The effect of water decoction of Bhizoma acori tatarinowii was weaker than that of Fluoxetine. There was a significant difference between every dose group of Rhizoma acori tatarinowii and saline control group. Conclusion:The water decoction of Rhizoma acori tatarinowii possessed obviously antidepressant effect in the behavioural despair animal models of depression.%目的:对石菖蒲水煎剂的抗抑郁作用进行筛选研究。方法:用小鼠尾悬挂试验和大鼠强迫游泳试验抑郁模型对石菖蒲水煎剂的抗抑郁作用进行研究。结果:在小鼠尾悬挂试验和大鼠强迫游泳试验中,石菖蒲水煎剂与氟西汀一样可以使小鼠尾悬挂的失望时间和大鼠强迫游泳的不动时间显著缩短,并呈一定的剂量依赖性,但其药理作用比氟西汀弱。石菖蒲的各剂量组与生理盐水对照组比较,统计学上有非常显著性差异。结论:石菖蒲水煎剂在行为绝望动物抑郁模型上有明显抗抑郁作用。

  20. Preserved semantic access in neglect dyslexia.

    Science.gov (United States)

    Làdavas, E; Shallice, T; Zanella, M T

    1997-03-01

    The aim of this study was to investigate the preservation of semantic access in patients with severe neglect dyslexia for words and non-words. Patients were given the following tasks: (1) reading aloud letter strings (first basic reading task), (2) making semantic decisions (categorial and inferential judgements), (3) making semantic decisions and reading the letter strings immediately afterwards (semantic-reading tasks), (4) reading letter strings again (final basic reading tasks) and (5) auditory control tasks. Of 23 patients with visual neglect, four showed neglect dyslexia for both words and non-words. Of these four patients, three showed a performance in the semantic tasks that was as good as in the auditory condition. Moreover, the reading of the patients improved dramatically in the semantic-reading tasks but this was not maintained in the final basic reading task. Non-words showed only a minor improvement. Findings are discussed in terms of an interaction between the attentional system and the different reading routes, and provide evidence that semantic routes are less affected by neglect.

  1. Pure Left Neglect for Arabic Numerals

    Science.gov (United States)

    Priftis, Konstantinos; Albanese, Silvia; Meneghello, Francesca; Pitteri, Marco

    2013-01-01

    Arabic numerals are diffused and language-free representations of number magnitude. To be effectively processed, the digits composing Arabic numerals must be spatially arrangspan>ed along a left-to-right axis. We studied one patient (AK) to show that left neglect, after right hemisphere damage, can selectively impair the computation of the spatial…

  2. The control of neglected zoonotic diseases

    DEFF Research Database (Denmark)

    Abela-Ridder, Bernadette; Welburn, Sue; Johansen, Maria Vang;

    on accelerating work to overcome the global impact of neglected tropical diseases (NTDs) and Resolution WHA66.12 on NTDs adopted by the World Health Assembly in May 2013 have enhanced visibility of zoonotic NTDs¬ – notably rabies, cysticercosis, echinococcosis, human African trypanosomiasis, foodborne...

  3. The Neglected Tools Can Work for You

    Science.gov (United States)

    Ramirez, Mac M.

    2012-01-01

    Of all the resources and techniques available to the classroom teacher of English as a second or foreign language, none are more neglected than audiovisual aids. Properly planned, constructed, and employed, such aids can help not only to improve the overall language program but also to enhance the classroom atmosphere and to ensure greater student…

  4. Pure Left Neglect for Arabic Numerals

    Science.gov (United States)

    Priftis, Konstantinos; Albanese, Silvia; Meneghello, Francesca; Pitteri, Marco

    2013-01-01

    Arabic numerals are diffused and language-free representations of number magnitude. To be effectively processed, the digits composing Arabic numerals must be spatially arranged along a left-to-right axis. We studied one patient (AK) to show that left neglect, after right hemisphere damage, can selectively impair the computation of the spatial…

  5. Altered dopamine signaling in naturally occurring maternal neglect.

    Directory of Open Access Journals (Sweden)

    Stephen C Gammie

    Full Text Available BACKGROUND: Child neglect is the most common form of child maltreatment, yet the biological basis of maternal neglect is poorly understood and a rodent model is lacking. METHODOLOGY/PRINCIPAL FINDINGS: The current study characterizes a population of mice (MaD1 which naturally exhibit maternal neglect (little or no care of offspring at an average rate of 17% per generation. We identified a set of risk factors that can predict future neglect of offspring, including decreased self-grooming and elevated activity. At the time of neglect, neglectful mothers swam significantly more in a forced swim test relative to nurturing mothers. Cross-fostered offspring raised by neglectful mothers in turn exhibit increased expression of risk factors for maternal neglect and decreased maternal care as adults, suggestive of possible epigenetic contributions to neglect. Unexpectedly, offspring from neglectful mothers elicited maternal neglect from cross-fostered nurturing mothers, suggesting that factors regulating neglect are not solely within the mother. To identify a neurological pathway underlying maternal neglect, we examined brain activity in neglectful and nurturing mice. c-Fos expression was significantly elevated in neglectful relative to nurturing mothers in the CNS, particularly within dopamine associated areas, such as the zona incerta (ZI, ventral tegmental area (VTA, and nucleus accumbens. Phosphorylated tyrosine hydroxylase (a marker for dopamine production was significantly elevated in ZI and higher in VTA (although not significantly in neglectful mice. Tyrosine hydroxylase levels were unaltered, suggesting a dysregulation of dopamine activity rather than cell number. Phosphorylation of DARPP-32, a marker for dopamine D1-like receptor activation, was elevated within nucleus accumbens and caudate-putamen in neglectful versus nurturing dams. CONCLUSIONS/SIGNIFICANCE: These findings suggest that atypical dopamine activity within the maternal brain

  6. Quo Vadis Venomics? A Roadmap to Neglected Venomous Invertebrates

    Directory of Open Access Journals (Sweden)

    Bjoern Marcus von Reumont

    2014-12-01

    Full Text Available Venomics research is being revolutionized by the increased use of sensitive -omics techniques to identify venom toxins and their transcripts in both well studied and neglected venomous taxa. The study of neglected venomous taxa is necessary both for understanding the full diversity of venom systems that have evolved in the animal kingdom, and to robustly answer fundamental questions about the biology and evolution of venoms without the distorting effect that can result from the current bias introduced by some heavily studied taxa. In this review we draw the outlines of a roadmap into the diversity of poorly studied and understood venomous and putatively venomous invertebrates, which together represent tens of thousands of unique venoms. The main groups we discuss are crustaceans, flies, centipedes, non-spider and non-scorpion arachnids, annelids, molluscs, platyhelminths, nemerteans, and echinoderms. We review what is known about the morphology of the venom systems in these groups, the composition of their venoms, and the bioactivities of the venoms to provide researchers with an entry into a large and scattered literature. We conclude with a short discussion of some important methodological aspects that have come to light with the recent use of new -omics techniques in the study of venoms.

  7. Suicidal behaviour

    NARCIS (Netherlands)

    Neeleman, J

    2001-01-01

    -Prevention of suicidal behaviour remains difficult, despite increasing knowledge of its determinants. Health service efforts hardly affect suicide rates. -Recent shifts in the epidemiology of suicidal behaviour are rising rates among the young and increasing use of violent methods. these can be lin

  8. Hookworm infection: A neglected tropical disease of mankind

    Directory of Open Access Journals (Sweden)

    Muhammed Hossain

    2016-12-01

    Full Text Available Hookworm infection, a global problem of human, is caused by both Ancylostoma duodenale and Necator americanus. These parasites are considered as important blood feeding nematodes. Hookworm is usually prevalent among the people who live with low socio-economic status. However, this tropical disease is neglected in most cases. This review was aimed at investigating the insights of hookworm infection of human considering its epidemiology, pathogenesis, clinical manifestation, diagnosis, treatment, immune mechanism, prevention, and control. This study showed how hookworm infection poses a global burden and infects 438.9 million people around the word annualy, and causes significant morbidity among the children and adult in endemic countries. Also, this review discussed how hookworm infection threatens the mankind causing serious health hazards. [J Adv Vet Anim Res 2016; 3(4.000: 297-320

  9. Theriocide: Naming Animal Killing

    Directory of Open Access Journals (Sweden)

    Piers Beirne

    2014-08-01

    Full Text Available In this essay I recommend ‘theriocide’ as the name for those diverse human actions that cause the deaths of animals. Like the killing of one human by another, theriocide may be socially acceptable or unacceptable, legal or illegal. It may be intentional or unintentional and may involve active maltreatment or passive neglect. Theriocide may occur one-on-one, in small groups or in large-scale social institutions. The numerous and sometimes intersecting sites of theriocide include intensive rearing regimes; hunting and fishing; trafficking; vivisection; militarism; pollution; and human-induced climate change. If the killing of animals by humans is as harmful to them as homicide is to humans, then the proper naming of such deaths offers a remedy, however small, to the extensive privileging of human lives over those of other animals. Inevitably, the essay leads to a shocking question: Is theriocide murder?

  10. Do Animals Have Memes?

    NARCIS (Netherlands)

    Reader, S.M.; Laland, K.N.

    1999-01-01

    Imitation has been put forward as a defining feature of memetic transmission. Since there is currently poor evidence for imitation in non-human animals, such definitions have been interpreted as restricting meme theory to the study of human behaviour patterns and birdsong. We believe this is a mista

  11. Pathological anxiety in animals

    NARCIS (Netherlands)

    Ohl, F.; Arndt, S.S.; Staay, van der F.J.

    2008-01-01

    selective breeding programmes in domestic and laboratory animals generally focus on physiological and/or anatomical characteristics. However, selection may have an (unintended) impact on other characteristics and may lead to dysfunctional behaviour that can affect biological functioning and, as a co

  12. Animal Behaviour: Friendship Enhances Trust in Chimpanzees.

    Science.gov (United States)

    Silk, Joan

    2016-01-25

    Individuals that participate in exchanges with delayed rewards can be exploited if their partners don't reciprocate. In humans, friendships are built on trust, and trust enhances cooperation. New evidence suggests that close social bonds also enhance trust in chimpanzees.

  13. Nutritional Status in Self-Neglecting Elderly

    Science.gov (United States)

    Oliver, S. Mathews; Kelly, P. A.; Pickens, S.; Burnett, J.; Dyer, C. B.; Smith, S. M.

    2006-01-01

    Elder self-neglect is the most common, and most compelling form of elder mistreatment. Individuals who cannot provide the basic needs for themselves may develop social, functional, and physical deficits. The CREST project has the goal of systematically characterizing these individuals, and the objective of the study reported here is to characterize aspects of their nutritional status. Self-neglect (SN) subjects referred from Adult Protective Services were recruited and consented. Control (CN) subjects were matched for age, gender, race, and socio-economic status when possible. Reported here are data on 47 SN subjects (age 77 +/- 7, mean +/- SD; body weight 76 kg +/- 26) and 40 CN subjects (77 +/- 7, 79 kg +/- 20). Blood samples were analyzed for indices of nutritional status. SN subjects had higher serum concentrations of homocysteine (p elderly population is at risk with respect to several markers of nutritional status.

  14. Child Abuse-Neglect and Forensic Odontology

    Directory of Open Access Journals (Sweden)

    Zehtiye Fusun Yasar

    2007-10-01

    Full Text Available The battered child syndrome, a behavioral deviation exposing children to harmful, non-accidental and preventable physical treatment of person or people who are responsible to look after them which prevents their physical and psycosocial development and conflicts with the cultural values of the society, is style of great importance today as an undissolved humanity problem. Child abuse is considered among the most severe forms of chidhood trauma due to its repeatability, and to its being performed by those closest to the victim. Its diagnosis is very difficult, and therefore so is its treatment. Its physical, psychological and social consequences appear in the long run. The awereness, experience and motivation of the physician are extremely important for diagnosis. Forensic deontologists have a very important role to describe the child abuse and neglect. When they examine the child they can find many evidence about abuse and neglect in oral cavity. Therefore when a child has oral injuries or dental neglect is suspected, the child will benefit from the physician's consultation with a pediatric dentist or a dentist with formal training in forensic odontology. Multidisciplinary teams for identifying and evaluating cases of child abuse and neglect present one option for collaboration. In that case physicians, dentists and child care workers working together can assist each other in the detection and of the effects of child abuse. This article is planned, to underline the seriousness and importance of the law, to clarify deficiencies of the law and to take attention of related people. [TAF Prev Med Bull 2007; 6(5.000: 389-394

  15. Child Abuse-Neglect and Forensic Odontology

    Directory of Open Access Journals (Sweden)

    Zehtiye Fusun Yasar

    2007-10-01

    Full Text Available The battered child syndrome, a behavioral deviation exposing children to harmful, non-accidental and preventable physical treatment of person or people who are responsible to look after them which prevents their physical and psycosocial development and conflicts with the cultural values of the society, is style of great importance today as an undissolved humanity problem. Child abuse is considered among the most severe forms of chidhood trauma due to its repeatability, and to its being performed by those closest to the victim. Its diagnosis is very difficult, and therefore so is its treatment. Its physical, psychological and social consequences appear in the long run. The awereness, experience and motivation of the physician are extremely important for diagnosis. Forensic deontologists have a very important role to describe the child abuse and neglect. When they examine the child they can find many evidence about abuse and neglect in oral cavity. Therefore when a child has oral injuries or dental neglect is suspected, the child will benefit from the physician's consultation with a pediatric dentist or a dentist with formal training in forensic odontology. Multidisciplinary teams for identifying and evaluating cases of child abuse and neglect present one option for collaboration. In that case physicians, dentists and child care workers working together can assist each other in the detection and of the effects of child abuse. This article is planned, to underline the seriousness and importance of the law, to clarify deficiencies of the law and to take attention of related people. [TAF Prev Med Bull. 2007; 6(5: 389-394

  16. Medicolegal aspects of child abuse and neglect.

    Science.gov (United States)

    Krugman, Richard D; Bross, Donald C

    2002-04-01

    Neurosurgeons that see children and care for those with traumatic injury are highly likely to see cases of child abuse and neglect. That fact makes it inevitable that they will encounter the legal system. It is hoped that this article has demystified the legal process and systems that one encounters in day-to-day practice. Avoiding the diagnosis of abuse because of lack of knowledge or phobia of the legal system is hazardous to the health and well-being of children.

  17. Oviposition behaviour of Phlebotomus argentipes - A laboratory-based study

    Directory of Open Access Journals (Sweden)

    Vijay Kumar

    2013-12-01

    Full Text Available The breeding habitat of sandflies is a little studied and poorly understood phenomenon. More importantly, oviposition behaviour is a largely neglected aspect of sandfly biology and this knowledge gap further undermines our understanding of the biology of sandflies. Pheromones released by the eggs play an important role in identifying good sites for oviposition by female insects. Several recent studies have examined the oviposition pheromone. The present study provides a preliminary report on the oviposition behaviour of Phlebotomus argentipes, the only vector of kala-azar (or visceral leishmaniasis on the Indian sub-continent. Sandflies prefer to oviposit their eggs on surfaces that contain organic substances, especially substances with an odour of decaying animal products and the remains of conspecific eggs. The results presented here suggest that the odour released by the organic substances of old sandfly colony remains that contain dead flies, old unhatched eggs, larval food containing vertebrate faeces, frass and other organic matter serves as an attractant for the ovipositing females of P. argentipes and hence greatly increases the number of oviposited eggs compared to eggs deposited in controlled oviposition pots. This result will be helpful in maintaining an efficient colony of P. argentipes and may be a promising tool for monitoring and controlling the target insect as part of a synergistic approach.

  18. National Child Abuse and Neglect Data System Glossary

    Science.gov (United States)

    ... Data System Glossary Listen Child Abuse and Neglect Data System Glossary Published: March 31, ... This document is the glossary for the National Child Abuse and Neglect Data System (NCANDS), including terms from ...

  19. Is there a critical lesion site for unilateral spatial neglect? A meta-analysis using activation likelihood estimation.

    Directory of Open Access Journals (Sweden)

    Pascal eMolenberghs

    2012-04-01

    Full Text Available The critical lesion site responsible for the syndrome of unilateral spatial neglect has been debated for more than a decade. Here we performed an activation likelihood estimation (ALE to provide for the first time an objective quantitative index of the consistency of lesion sites across anatomical group studies of spatial neglect. The analysis revealed several distinct regions in which damage has consistently been associated with spatial neglect symptoms. Lesioned clusters were located in several cortical and subcortical regions of the right hemisphere, including the middle and superior temporal gyrus, inferior parietal lobule, intraparietal sulcus, precuneus, middle occipital gyrus, caudate nucleus and posterior insula, as well as in the white matter pathway corresponding to the posterior part of the superior longitudinal fasciculus. Further analyses suggested that separate lesion sites are associated with impairments in different behavioural tests, such as line bisection and target cancellation. Similarly, specific subcomponents of the heterogeneous neglect syndrome, such as extinction and allocentric and personal neglect, are associated with distinct lesion sites. Future progress in delineating the neuropathological correlates of spatial neglect will depend upon the development of more refined measures of perceptual and cognitive functions than those currently available in the clinical setting.

  20. The generation of animated sequences from state transition systems.

    OpenAIRE

    Clark, Tony; Palmer, I. J.

    1995-01-01

    We address the issue of the construction of a computer animation system by composing together a collection of behaviours for the individual objects which are to be animated. The behaviours are developed using a formal notation for state transition systems. The notation is particularly flexible, allowing both a constructive and constraining aproach to behaviour representation. The behaviour necessary for animating Newton's Cradle for an arbitrary number of spheres is developed as an example of...

  1. Behavioural Modernity

    OpenAIRE

    McLean, Laura

    2015-01-01

    Behavioural Modernity explores the changing politics of representation and ethics of care in curatorial practice, necessitated by an increasing blurring of boundaries between the human, the technological, and the planetary.

  2. The Effect of Syntax on Reading in Neglect Dyslexia

    Science.gov (United States)

    Friedmann, Naama; Tzailer-Gross, Lital; Gvion, Aviah

    2011-01-01

    Individuals with text-based neglect dyslexia omit words on the neglected side of the sentence or text, usually on the left side. This study tested whether the syntactic structure of the target sentence affects reading in this type of neglect dyslexia. Because Hebrew is read from right to left, it enables testing whether the beginning of the…

  3. Defining Child Neglect Based on Child Protective Services Data

    Science.gov (United States)

    Dubowitz, H.; Pitts, S.C.; Litrownik, A.J.; Cox, C.E.; Runyan, D.; Black, M.M.

    2005-01-01

    Objectives:: To compare neglect defined by Child Protective Services official codes with neglect defined by a review of CPS narrative data, and to examine the validity of the different neglect measures using children's functioning at age 8 years. Methods:: Data are from 740 children participating in a consortium of longitudinal studies on child…

  4. 45 CFR 1357.20 - Child abuse and neglect programs.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Child abuse and neglect programs. 1357.20 Section... APPLICABLE TO TITLE IV-B § 1357.20 Child abuse and neglect programs. The State agency must assure that, with regard to any child abuse and neglect programs or projects funded under title IV-B of the Act,...

  5. Incorporating animal spatial memory in step selection functions.

    Science.gov (United States)

    Oliveira-Santos, Luiz Gustavo R; Forester, James D; Piovezan, Ubiratan; Tomas, Walfrido M; Fernandez, Fernando A S

    2016-03-01

    Memory is among the most important and neglected forces that shapes animal movement patterns. Research on the movement-memory interface is crucial to understand how animals use spatial learning to navigate across space because memory-based navigation is directly linked to animals' space use and home range behaviour; however, because memory cannot be measured directly, it is difficult to account for. Here, we incorporated spatial memory into step selection functions (SSF) to understand how resource selection and spatial memory affect space use of feral hogs (Sus scrofa). We used Biased Random Bridge kernel estimates linked to residence time as a surrogate for memory and tested four conceptually different dynamic maps of spatial memory. We applied this memory-based SSF to a data set of hog relocations to evaluate the importance of land cover type, time of day and spatial memory on the animals' space use. Our approach has shown how the incorporation of spatial memory into animal movement models can improve estimates of habitat selection. Memory-based SSF provided a feasible way to gain insight into how animals use spatial learning to guide their movement decisions. We found that while hogs selected forested areas and water bodies and avoided grasslands during the day (primarily at noon), they had a strong tendency to select previously visited areas, mainly those held in recent memory. Beyond actively updating their memory with recent experiences, hogs were able to discriminate among spatial memories encoded at different circadian phases of their activity. Even though hogs are thought to have long memory retention, they likely relied on recent experiences because the local food resources are quickly depleted and slowly renewed, yielding an uncertain spatial distribution of resources.

  6. Prevention of child abuse and neglect and improvements in child development

    DEFF Research Database (Denmark)

    Christoffersen, Mogens; DePanfilis, Diane

    2009-01-01

    . The questionnaire explored the impact of various interventions, including services geared to strengthen the child's network, but results indicated that the child displayed reduced risk of reactive symptoms only when parental behaviour improved and abuse and neglect were reduced.......The aim of the study was to evaluate the implementation of a section in the Danish Social Assistance Act which encourages local authorities to offer families services in order to support children at risk of child maltreatment. The specific purpose of the present paper is to answer the question......: Will the socio-psychological development of children known to social services be improved when abuse and neglect are reduced? A sample of 1,138 children was drawn at random from new social services cases starting in 1998. Subsequently, about 80 per cent were evaluated by local caseworkers on the basis...

  7. Behavioural lateralisation in reindeer

    Directory of Open Access Journals (Sweden)

    Yngve Espmark

    2002-06-01

    Full Text Available Reindeer (Rangifer tarandus kept in corrals or otherwise forced to clump typically start milling in response to stressing events. This behaviour is generally considered to have an antipredator effect. An inquiry on herd behaviour, to which 35 Norwegian reindeer husbandry districts responded, showed that 32 experienced that corralled rein¬deer consistently circled leftwards, whereas the remaining three reported consistently rightward circling. Regular monitoring of a reindeer herd in central Norway over a two-year period (1993-94, and experimental studies on a fraction of the same herd, revealed the following traits. Free-ranging reindeer showed no right- or left-turning preference during grazing or browsing, but when the reindeer were driven into corrals or forced to clump in the open they invariably rotated leftwards. The circling of corralled reindeer was triggered at an average group size of 20 to 25 animals, apparently independently of the age and sex of the animals. When they dug craters in the snow to reach food, the reindeer used their left foreleg significantly more often than their right. In 23 out of 35 reindeer, the right hemisphere of the brain was heavier than the left. However, in the sample as a whole, the weights of the left and right hemispheres did not differ significantly. Lateralised behaviour in reindeer is thought to be determined by natural and stress induced asymmetries in brain structure and hormonal activity. In addition, learning is probably important for passing on the behaviour between herd members and generations. Differences in lateralised behaviour between nearby herds are thought to be related primarily to different exposure to stress and learning, whereas genetical and environmental fac¬tors (e.g. diet, age structure and sex ratio are probably more important for explaining differences between distant pop¬ulations.

  8. Animal agriculture: symbiosis, culture or ethical conflict?

    OpenAIRE

    Lund, Vonne; Olsson, I Anna S

    2006-01-01

    Several writers on animal ethics defend the abolition of most or all animal agriculture, which they consider an unethical exploitation of sentient non-human animals. However, animal agriculture can also be seen as a co-evolution over thousands of years, that has affected biology and behaviour on the one hand, and quality of life of humans and domestic animals on the other. Furthermore, animals are important in sustainable agriculture. They can increase efficiency by their ability to transform...

  9. Morphology and behaviour : functional links in development and evolution Introduction

    NARCIS (Netherlands)

    Bertossa, Rinaldo C.

    2011-01-01

    Development and evolution of animal behaviour and morphology are frequently addressed independently, as reflected in the dichotomy of disciplines dedicated to their study distinguishing object of study (morphology versus behaviour) and perspective (ultimate versus proximate). Although traits are kno

  10. Example Elaboration as a Neglected Instructional Strategy

    Energy Technology Data Exchange (ETDEWEB)

    Girill, T R

    2001-07-18

    Over the last decade an unfolding cognitive-psychology research program on how learners use examples to develop effective problem solving expertise has yielded well-established empirical findings. Chi et al., Renkl, Reimann, and Neubert (in various papers) have confirmed statistically significant differences in how good and poor learners inferentially elaborate (self explain) example steps as they study. Such example elaboration is highly relevant to software documentation and training, yet largely neglected in the current literature. This paper summarizes the neglected research on example use and puts its neglect in a disciplinary perspective. The author then shows that differences in support for example elaboration in commercial software documentation reveal previously over looked usability issues. These issues involve example summaries, using goals and goal structures to reinforce example elaborations, and prompting readers to recognize the role of example parts. Secondly, I show how these same example elaboration techniques can build cognitive maturity among underperforming high school students who study technical writing. Principle based elaborations, condition elaborations, and role recognition of example steps all have their place in innovative, high school level, technical writing exercises, and all promote far transfer problem solving. Finally, I use these studies to clarify the constructivist debate over what writers and readers contribute to text meaning. I argue that writers can influence how readers elaborate on examples, and that because of the great empirical differences in example study effectiveness (and reader choices) writers should do what they can (through within text design features) to encourage readers to elaborate examples in the most successful ways. Example elaboration is a uniquely effective way to learn from worked technical examples. This paper summarizes years of research that clarifies example elaboration. I then show how example

  11. Lateral specialization in unilateral spatial neglect: a cognitive robotics model.

    Science.gov (United States)

    Conti, Daniela; Di Nuovo, Santo; Cangelosi, Angelo; Di Nuovo, Alessandro

    2016-08-01

    In this paper, we present the experimental results of an embodied cognitive robotic approach for modelling the human cognitive deficit known as unilateral spatial neglect (USN). To this end, we introduce an artificial neural network architecture designed and trained to control the spatial attentional focus of the iCub robotic platform. Like the human brain, the architecture is divided into two hemispheres and it incorporates bio-inspired plasticity mechanisms, which allow the development of the phenomenon of the specialization of the right hemisphere for spatial attention. In this study, we validate the model by replicating a previous experiment with human patients affected by the USN and numerical results show that the robot mimics the behaviours previously exhibited by humans. We also simulated recovery after the damage to compare the performance of each of the two hemispheres as additional validation of the model. Finally, we highlight some possible advantages of modelling cognitive dysfunctions of the human brain by means of robotic platforms, which can supplement traditional approaches for studying spatial impairments in humans.

  12. Somatization and somatic symptom presentation in cancer: a neglected area.

    Science.gov (United States)

    Grassi, Luigi; Caruso, Rosangela; Nanni, Maria Giulia

    2013-02-01

    Abstract The recognition of somatization process in cancer patients is a challenging and neglected area, for the extreme difficulty in differentiating and assessing the psycho(patho)logical components from those biologically determined and related to cancer and cancer treatment, as well as for the scarce usefulness of rigid categorical DSM criteria. However, several dimensions of somatization (and the interconnected concept of abnormal illness behaviour) have been shown to be diagnosable in cancer patients and to negatively influence coping and quality of life outcomes. An integration of the formal DSM-ICD nosology with a system specifically taking into account the patients' emotional responses to cancer and cancer treatment, such as the Diagnostic Criteria for Psychosomatic Research (DCPR), is suggested. More data on some specific symptom dimensions, including pain, fatigue and sexual disorders, are needed to examine their possible psychological components. More research is also needed regarding the association of somatization with personality traits (e.g. type D distressed personality, alexithymia), developmental dimensions (e.g. attachment), and cultural issues (e.g. culturally mediated attributional styles to somatic symptoms). Also, the impact and effectiveness of specific therapeutic intervention in 'somatizing' cancer patients is necessary.

  13. Evaluation of Child Abuse and Neglect

    Directory of Open Access Journals (Sweden)

    Selen Acehan

    2013-08-01

    Full Text Available Child abuse is an important public health problem that can cause serious injury, disability and even death, and have medical, legal, and social aspects. Prevention of repeated abuse at an early stage is necessary to limit long-term effects of abuse. Unfortunately, these children often do not receive the diagnosis in the emergency department, despite using emergency service. We aimed at the evaluation and management of child abuse and neglect which has a very important social dimension, in the light of the latest information. [Archives Medical Review Journal 2013; 22(4.000: 591-614

  14. Mansonelliasis, a neglected parasitic disease in Haiti.

    Science.gov (United States)

    Raccurt, Christian Pierre; Brasseur, Philippe; Boncy, Jacques

    2014-09-01

    Reported in Haiti as early as 1923, Mansonella ozzardi is still a neglected disease ignored by the health authorities of the country. This review is an update on the geographic distribution of the coastal foci of mansonelliasis in Haiti, the epidemiological profile and prevalence rates of microfilariae in people living in endemic areas, the clinical impact of the parasite on health and the efficiency of the transmission of the parasite among three Culicoides biting-midge species identified as vectors in Haiti. Additionally, interest in establishing a treatment programme to combat this parasite using a single dose of ivermectin is emphasised.

  15. Neglected giant scalp Basal cell carcinoma

    DEFF Research Database (Denmark)

    Larsen, Anne Kristine; El-Charnoubi, Waseem-Asim Ghulam; Gehl, Julie;

    2014-01-01

    SUMMARY: Rarely, basal cell carcinoma grows to a giant size, invading the underlying deep tissue and complicating the treatment and reconstruction modalities. A giant basal cell carcinoma on the scalp is in some cases treated with a combination of surgery and radiation therapy, resulting in local...... control, a satisfactory long-term cosmetic and functional result. We present a case with a neglected basal cell scalp carcinoma, treated with wide excision and postoperative radiotherapy, reconstructed with a free latissimus dorsi flap. The cosmetic result is acceptable and there is no sign of recurrence...

  16. Neglected Giant Scalp Basal Cell Carcinoma

    Directory of Open Access Journals (Sweden)

    Anne Kristine Larsen, MD

    2014-03-01

    Full Text Available Summary: Rarely, basal cell carcinoma grows to a giant size, invading the underlying deep tissue and complicating the treatment and reconstruction modalities. A giant basal cell carcinoma on the scalp is in some cases treated with a combination of surgery and radiation therapy, resulting in local control, a satisfactory long-term cosmetic and functional result. We present a case with a neglected basal cell scalp carcinoma, treated with wide excision and postoperative radiotherapy, reconstructed with a free latissimus dorsi flap. The cosmetic result is acceptable and there is no sign of recurrence 1 year postoperatively.

  17. Personal neglect-a disorder of body representation?

    Science.gov (United States)

    Baas, Ulrike; de Haan, Bianca; Grässli, Tanja; Karnath, Hans-Otto; Mueri, René; Perrig, Walter J; Wurtz, Pascal; Gutbrod, Klemens

    2011-04-01

    The cognitive mechanisms underlying personal neglect are not well known. One theory postulates that personal neglect is due to a disorder of contralesional body representation. In the present study, we have investigated whether personal neglect is best explained by impairments in the representation of the contralesional side of the body, in particular, or a dysfunction of the mental representation of the contralesional space in general. For this, 22 patients with right hemisphere cerebral lesions (7 with personal neglect, 15 without personal neglect) and 13 healthy controls have been studied using two experimental tasks measuring representation of the body and extrapersonal space. In the tasks, photographs of left and right hands as well as left and right rear-view mirrors presented from the front and the back had to be judged as left or right. Our results show that patients with personal neglect made more errors when asked to judge stimuli of left hands and left rear-view mirrors than either patients without personal neglect or healthy controls. Furthermore, regression analyses indicated that errors in interpreting left hands were the best predictor of personal neglect, while other variables such as extrapersonal neglect, somatosensory or motor impairments, or deficits in left extrapersonal space representation had no predictive value of personal neglect. These findings suggest that deficient body representation is the major mechanism underlying personal neglect.

  18. Using narratives and discourses in neglect-prevention training.

    Science.gov (United States)

    Price, Bob

    2013-06-01

    Training in neglect prevention for healthcare professionals should incorporate understanding of who is at risk, what represents neglect, how signs might be identified quickly and what should be done to rectify neglectful practice and minimise further risk. It must also cover accurate reporting in line with safeguarding vulnerable adults legislation and the evaluation of what healthcare systems have contributed to the risk of neglect. Neglect is an ambiguous term, so it is important to explore how it is understood and why sometimes it is not challenged. This article discusses various issues around neglect and suggests a new approach to training that involves the analysis of clients' and practitioners' narratives and discourses about care. Understanding these narratives and discourses can help identify situations of institutional neglect.

  19. Unilateral neglect and perceptual parsing: a large-group study.

    Science.gov (United States)

    Neppi-Mòdona, Marco; Savazzi, Silvia; Ricci, Raffaella; Genero, Rosanna; Berruti, Giuseppina; Pepi, Riccardo

    2002-01-01

    Array-centred and subarray-centred neglect were disambiguated in a group of 116 patients with left neglect by means of a modified version of the Albert test in which the central column of segments was deleted so as to create two separate sets of targets grouped by proximity. The results indicated that neglect was more frequent in array- than subarray-centred coordinates and that, in a minority of cases, neglect co-occurred in both coordinate-systems. The two types of neglect were functionally but not anatomically dissociated. Presence of visual field defects was not prevalent in one type of neglect with respect to the other. These data contribute further evidence to previous single-case and small-group studies by showing that neglect can occur in single or multiple reference frames simultaneously, in agreement with current neuropsychological, neurophysiological and computational concepts of space representation.

  20. Behaviour - The keystone in optimizing free-ranging ungulate production

    Science.gov (United States)

    Free-ranging animal behaviour is a keystone to optimizing free-ranging domestic animal production. This chapter focuses on several aspects that emanate from foraging including defining terms, concepts and the complexity that underlie managing animals and landscapes. Behaviour is investigated in li...

  1. 25 CFR 11.446 - Cruelty to animals.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Cruelty to animals. 11.446 Section 11.446 Indians BUREAU... ORDER CODE Criminal Offenses § 11.446 Cruelty to animals. A person commits a misdemeanor if he or she purposely or recklessly: (a) Subjects any animal in his or her custody to cruel neglect; or (b) Subjects...

  2. Knowledge of the animal welfare act and animal welfare regulations influences attitudes toward animal research.

    Science.gov (United States)

    Metzger, Mitchell M

    2015-01-01

    Recent public-opinion polls indicate that Americans have shown a decline in support for animal experimentation, and several reports suggest a relationship between people's knowledge of animal welfare regulations and their attitudes toward animal research. Therefore, this study was designed to assess respondent's knowledge of several provisions in the Animal Welfare Act (AWA) and Animal Welfare Regulations (AWR), and determine whether exposure to elements of this legislation would influence an individual's attitudes toward the use of animals in research. A survey was used to assess knowledge of animal research regulations and attitudes toward animal research from a sample of individuals recruited through Amazon's Mechanical Turk crowdsourcing marketplace. Results from study 1 confirmed the hypothesis that respondents had little knowledge of various federal regulations that govern animal research activities. Data from study 2 revealed that exposure to elements of the AWA and AWR influenced participants' attitudes toward the use of animals in research. These results suggest that providing information to the general public about the AWA and AWR that protect laboratory animals from abuse and neglect may help alleviate concerns about using animals in research settings.

  3. Behaviour Genetics of Pigs

    Directory of Open Access Journals (Sweden)

    Kristina Budimir

    2013-09-01

    Full Text Available The behavior of pigs can be divided into several categories, which include maternal behavior, aggressive behavior, sexual behavior, feeding behavior, and various other forms of emotional behavior. Domestication has caused many changes in the original behaviour of boar, such as in reproductive and sexual behaviour, and has lead to a general increase in social tolerance between animals. Further modifications in behaviour are also possible, as suggested by the optimization of environmental factors which affect maternal behavior. The behaviour of a sow after farrowing appeared as a consequence of natural selection for protection of piglets from predators in the wild boar population, and affects the survival of piglets and the longevity of the sow in breeding. The behavior of the sows which includes the protection of the piglets from predators appears as a consequence of natural selection in the wild boar population. Familiarity with the molecular mechanisms which determine the patterns of behavior enables understanding of behavioral problems such as aggressiveness and helps the improvement of the well-being of pigs. Research conducted on pigs has determined that there are regions on chromosomes 2, 6, 10, 14, and 15, and chromosome X which can explain the genetic aspect of appearance of some behavioral patterns in sows. The goal of this paper is to illustrate the behavioral patterns appeared in the populations of domestic breeds of pigs and their genetic aspects, which knowledge may provide some help in improving the production qualities and creating higher economic gain during production.

  4. Chronic neglect and aggression/delinquency: A longitudinal examination.

    Science.gov (United States)

    Logan-Greene, Patricia; Semanchin Jones, Annette

    2015-07-01

    Neglect is the most common form of maltreatment in the United States, yet its impact on development remains understudied, especially for chronic neglect. Chronic neglect is also one of the most costly burdens on child welfare systems. This study examines the effects of chronic neglect, including two subtypes (Failure to Provide and Lack of Supervision) on adolescent aggression and delinquency using a diverse longitudinal sample of youth. Chronic neglect and chronic failure to provide (ages 0-12) predicted aggression/delinquency (age 14) even after controlling for the effects of other maltreatment (ages 0-12). Chronic lack of supervision, however, did not. Gender significantly moderated these effects, suggesting that males are more likely to respond to neglect by becoming aggressive/delinquent. Finally, social problems (age 12) partially mediated for boys, and fully mediated for girls, the connections between chronic neglect and aggression/delinquency, bolstering theorizing that neglect impairs social functioning broadly. Implications include the need for further research on chronic neglect, especially in providing guidance for child welfare systems. Interventions for chronically neglected youth should include social skill development.

  5. The Computerized Table Setting Test for Detecting Unilateral Neglect.

    Directory of Open Access Journals (Sweden)

    Seok Jong Chung

    Full Text Available Patients with unilateral neglect fail to respond normally to stimuli on the left side. To facilitate the evaluation of unilateral spatial neglect, we developed a new application that runs on a tablet device and investigated its feasibility in stroke patients.We made the computerized table setting test (CTST to run on the tablet computer. Forty acute ischemic stroke patients (20 patients with right hemispheric infarction with neglect, 10 patients with right hemispheric infarction without neglect, and 10 patients with left hemispheric infarction and 10 healthy controls were prospectively enrolled to validate the CTST. The test requires subjects to set a table by dragging 12 dishes located below the table on the tablet screen. The horizontal deviation of the 12 dishes from the midline of the table, the selection tendency measured by the sequence of the dish selection, and the elapsed time for table setting were calculated automatically.Parameters measured by the CTST were correlated with the results of conventional neglect tests. The horizontal deviation was significantly higher in patients with right hemispheric infarction with neglect compared with the other groups. The selection tendency and elapsed time also were significantly different in patients with right hemispheric infarction with neglect compared with the left hemispheric infarction and control groups, but were similar to those with right hemispheric infarction without neglect.The CTST is feasible to administer and comparable with conventional neglect tests. This new application may be useful for the initial diagnosis and follow-up of neglect patients.

  6. Consumer behaviours

    DEFF Research Database (Denmark)

    Grønhøj, Alice

    2016-01-01

    Energy-saving programmes are increasingly targeted at children to encourage household energy conservation. A study involving the assignment of energy-saving interventions to Girl Scouts shows that a child-focused intervention can improve energy-saving behaviours among children and their parents....

  7. Rift Valley fever: A neglected zoonotic disease?

    Science.gov (United States)

    Rift Valley fever (RVF) is a serious viral disease of animals and humans in Africa and the Middle East that is transmitted by mosquitoes. First isolated in Kenya during an outbreak in 1930, subsequent outbreaks have had a significant impact on animal and human health, as well as national economies. ...

  8. Animal research

    DEFF Research Database (Denmark)

    Olsson, I.A.S.; Sandøe, Peter

    2012-01-01

    in research is analyzed from the viewpoint of three distinct ethical approaches: contractarianism, utilitarianism, and animal rights view. On a contractarian view, research on animals is only an ethical issue to the extent that other humans as parties to the social contract care about how research animals......This article presents the ethical issues in animal research using a combined approach of ethical theory and analysis of scientific findings with bearing on the ethical analysis. The article opens with a general discussion of the moral acceptability of animal use in research. The use of animals...... are faring. From the utilitarian perspective, the use of sentient animals in research that may harm them is an ethical issue, but harm done to animals can be balanced by benefit generated for humans and other animals. The animal rights view, when thoroughgoing, is abolitionist as regards the use of animals...

  9. Treatment of hemispatial neglect by means of rTMS--a review.

    Science.gov (United States)

    Cazzoli, Dario; Müri, René M; Hess, Christian W; Nyffeler, Thomas

    2010-01-01

    Hemispatial neglect - defined as the failure to attend, explore, and act upon the contralesional side of space - is a frequent and disabling neurological syndrome. Interhemispheric rivalry is considered as a major pathophysiological mechanism underlying hemispatial neglect. According to this account, the contralesional, intact hemisphere undergoes a pathological hyperactivity due to a deficient transcallosal inhibition from the damaged hemisphere. This model offers a framework for possible therapeutic interventions with repetitive transcranial magnetic stimulation (rTMS), i.e. a reduction of the pathological hyperactivity with a rTMS protocol that has lasting inhibitory effects. In the present work, we will first review evidence for the interhemispheric rivalry account coming from animals and humans. We will then describe studies showing the possibility to perturb and to restore interhemispheric balance in healthy subjects as a proof of concept for therapeutic rTMS application. Finally, we will consider studies applying rTMS as a therapeutic approach in hemispatial neglect. We conclude that rTMS is a promising approach to reduce the interhemispheric imbalance in neglect patients and to ameliorate symptoms. Newly developed protocols such as Theta Burst Stimulation (TBS) - with short stimulation times and long offline effects - seem to be particularly convenient. However, future studies should assess stimulation effects not only in clinical testing, but also on disability, considering combination with traditional therapies as well.

  10. Neglected Side Effects After Radical Prostatectomy

    DEFF Research Database (Denmark)

    Frey, Anders Ullmann; Sønksen, Jens; Fode, Mikkel

    2014-01-01

    INTRODUCTION: A series of previously neglected sexually related side effects to radical prostatectomy (RP) has been identified over the recent years. These include orgasm-associated incontinence (OAI), urinary incontinence in relation to sexual stimulation (UISS), altered perception of orgasm......, and the online Cochrane library. The PRISMA guidelines for systematic reviews were followed, and protocol as well as search strategies was registered at http://www.crd.york.ac.uk/Prospero/ (RN: CRD42012003165). MAIN OUTCOME MEASURE: The main outcome measure was incidence rates for the relevant side effects...... been shown to double the risk of OAP. PS occurs in 15-68% of RP patients. Nerve sparing and preservation of erectile function may help preserve penile length. With regard to all side effects, studies indicate that they are reduced over time. CONCLUSIONS: The sexually related side effects summarized...

  11. Sulfoximines: a neglected opportunity in medicinal chemistry.

    Science.gov (United States)

    Lücking, Ulrich

    2013-09-02

    Innovation has frequently been described as the key to drug discovery. However, in the daily routine, medicinal chemists often tend to stick to the functional groups and structural elements they know and love. Blockbuster cancer drug Velcade (bortezomib), for example, was rejected by more than 50 companies, supposedly because of its unusual boronic acid function (as often repeated: "only a moron would put boron in a drug!"). Similarly, in the discovery process of the pan-CDK inhibitor BAY 1000394, the unconventional proposal to introduce a sulfoximine group into the lead series also led to sneers and raised eyebrows, since sulfoximines have seldom been used in medicinal chemistry. However, it was the introduction of the sulfoximine group that finally allowed the fundamental issues of the project to be overcome, culminating in the identification of the clinical sulfoximine pan-CDK inhibitor BAY 1000394. This Minireview provides an overview of a widely neglected opportunity in medicinal chemistry--the sulfoximine group.

  12. [Human hantavirus diseases - still neglected zoonoses?].

    Science.gov (United States)

    Vrbovská, V; Chalupa, P; Straková, P; Hubálek, Z; Rudolf, I

    2015-10-01

    Hantavirus disease is the most common rodent-borne viral infection in the Czech Republic, with a mean annual incidence of 0.02 cases per 100 000 population and specific antibodies detected in 1% of the human population. Four hantaviruses (Puumala, Dobrava-Belgrade, Tula, and Seewis) circulate in this country, of which Puumala virus (responsible for a mild form of hemorrhagic fever with renal syndrome called nephropathia epidemica) and Dobrava-Belgrade virus (causing haemorrhagic fever with renal syndrome) have been proven to cause human disease. The aim of this study is to provide a comprehensive review of the hantaviruses occurring in the Czech Republic, based on the literature published during the past three decades, including their geographical distribution and clinical symptoms. The recent detection of Tula virus in an immunocompromised person as well as reports of Seoul virus infections in Europe highlight the possible emergence of neglected hantavirus infections in the foreseeable future.

  13. Neglected isolated fracture of the trochlea humeri

    Institute of Scientific and Technical Information of China (English)

    Ajay Pal Singh; Ish Kumar Dhammi; Anil Kumar Jain; Saurabh Jain

    2010-01-01

    A 15 years old girl was found to have isolated trochlea fracture 10 weeks after an injury caused by a fall on her left elbow. Movement of the elbow was severely restricted. Radiographs showed a half moon-shaped and anterosuperiorly displaced osteochondral fragment. Medial approach capsulotomy of the elbow and excision of the intraarticular adhesions were done to expose the isolated trochlea fracture. Headless screws were used for fixation,combined with bone grafting. The follow-up showed union and excellent functional recovery of the elbow. Isolated trochlea fracture in adults is rare and usually associated with capitellar fractures and/or elbow dislocations. A neglected trochlea fracture is rarely reported in the English language literature to the best of our knowledge. Recognition of isolated trochlea fracture is vital to apprehend the pathomechanics of the injury and to devise a suitable treatment approach.

  14. Priority setting and the 'neglected' tropical diseases.

    Science.gov (United States)

    Canning, David

    2006-06-01

    In this paper David Canning argues that interventions against 'neglected' tropical diseases should be thought of as investments in human capital and form an integral part of global poverty reduction. He argues that overall burden of disease should not be the criterion for priority setting; if the goal is to maximize health benefits from a fixed health budget then cost-effective interventions should be prioritized. Whilst many people find objectionable the assignment of a monetary value to health, a cost-benefit approach, combining health and economic benefits, would allow the health sector to present arguments to policy makers, based on the rate of return on investment. Since many health interventions in low-income countries have exceptionally high rankings in terms of cost-benefit ratios, this should result in large flows from other sectors to the health sector.

  15. Representational neglect for words as revealed by bisection tasks.

    Science.gov (United States)

    Arduino, Lisa S; Marinelli, Chiara Valeria; Pasotti, Fabrizio; Ferrè, Elisa Raffaella; Bottini, Gabriella

    2012-03-01

    In the present study, we showed that a representational disorder for words can dissociate from both representational neglect for objects and neglect dyslexia. This study involved 14 brain-damaged patients with left unilateral spatial neglect and a group of normal subjects. Patients were divided into four groups based on presence of left neglect dyslexia and representational neglect for non-verbal material, as evaluated by the Clock Drawing test. The patients were presented with bisection tasks for words and lines. The word bisection tasks (with words of five and seven letters) comprised the following: (1) representational bisection: the experimenter pronounced a word and then asked the patient to name the letter in the middle position; (2) visual bisection: same as (1) with stimuli presented visually; and (3) motor bisection: the patient was asked to cross out the letter in the middle position. The standard line bisection task was presented using lines of different length. Consistent with the literature, long lines were bisected to the right and short lines, rendered comparable in length to the words of the word bisection test, deviated to the left (crossover effect). Both patients and controls showed the same leftward bias on words in the visual and motor bisection conditions. A significant difference emerged between the groups only in the case of the representational bisection task, whereas the group exhibiting neglect dyslexia associated with representational neglect for objects showed a significant rightward bias, while the other three patient groups and the controls showed a leftward bisection bias. Neither the presence of neglect alone nor the presence of visual neglect dyslexia was sufficient to produce a specific disorder in mental imagery. These results demonstrate a specific representational neglect for words independent of both representational neglect and neglect dyslexia.

  16. Left neglect dyslexia: Perseveration and reading error types.

    Science.gov (United States)

    Ronchi, Roberta; Algeri, Lorella; Chiapella, Laura; Gallucci, Marcello; Spada, Maria Simonetta; Vallar, Giuseppe

    2016-08-01

    Right-brain-damaged patients may show a reading disorder termed neglect dyslexia. Patients with left neglect dyslexia omit letters on the left-hand-side (the beginning, when reading left-to-right) part of the letter string, substitute them with other letters, and add letters to the left of the string. The aim of this study was to investigate the pattern of association, if any, between error types in patients with left neglect dyslexia and recurrent perseveration (a productive visuo-motor deficit characterized by addition of marks) in target cancellation. Specifically, we aimed at assessing whether different productive symptoms (relative to the reading and the visuo-motor domains) could be associated in patients with left spatial neglect. Fifty-four right-brain-damaged patients took part in the study: 50 out of the 54 patients showed left spatial neglect, with 27 of them also exhibiting left neglect dyslexia. Neglect dyslexic patients who showed perseveration produced mainly substitution neglect errors in reading. Conversely, omissions were the prevailing reading error pattern in neglect dyslexic patients without perseveration. Addition reading errors were much infrequent. Different functional pathological mechanisms may underlie omission and substitution reading errors committed by right-brain-damaged patients with left neglect dyslexia. One such mechanism, involving the defective stopping of inappropriate responses, may contribute to both recurrent perseveration in target cancellation, and substitution errors in reading. Productive pathological phenomena, together with deficits of spatial attention to events taking place on the left-hand-side of space, shape the manifestations of neglect dyslexia, and, more generally, of spatial neglect.

  17. [Pain and fear in animals].

    Science.gov (United States)

    Loeffler, K

    1993-02-01

    Pain and fear are feelings of reluctance, which result in a behaviour of avoidance. They are protective mechanisms and are only partly approachable to the quantification with natural scientific methods. It will pointed to the central role of the diencephalon, limbic system and the cerebral cortex concerning the processing and valuation of mental state. The recognition of clinical symptoms and precise behavioural observations are an essential aid to assess the state of pain and fear in animals.

  18. Maori Identification, Alcohol Behaviour and Mental Health: A Review

    Science.gov (United States)

    Ebbett, Erin; Clarke, Dave

    2010-01-01

    The impact of Maori identification on alcohol behaviour and mental health and has been neglected in the psychological literature. This paper consists of a review of literature on the history of alcohol use in New Zealand and its impact on indigenous Maori, on their cultural identity and on their mental health. Previous research has been primarily…

  19. Are drawing perseverations part of the neglect syndrome?

    Science.gov (United States)

    Pia, Lorenzo; Folegatti, Alessia; Guagliardo, Marilena; Genero, Rosanna; Gindri, Patrizia

    2009-03-01

    Unilateral neglect patients typically omit to cancel contralesional targets. Moreover, they can repeatedly cancel ipsilesional stimuli exhibiting what is termed 'perseverative behavior'. Two alternative accounts of this behavior have been proposed. According to one of them, it is considered as integral to neglect and due either to a perceptual (allochiria), or a premotor (directional hypokinesia) pathological mechanism leading to the ipsilesional displacement of contralesional responses. According to the other one, perseverations are interpreted as the consequence of motor-control-disinhibition co-occurring with, although independent of, spatial neglect. We compared some crucial predictions of these two hypotheses on a group of 10 right-brain-damaged patients, eight with neglect and two without neglect, showing a perseverative behavior in both conventional and experimental cancellation tasks. In our experiment, the spatial location and the numerosity of targets were manipulated to obtain different degrees of horizontal alignment between targets on the left and on the right of the central vertical axis of the sheet. We found that ipsilesional perseverations were not influenced by left neglected targets and were not correlated to neglect severity. Additionally, perseverative errors were associated with right basal ganglia lesions rather than with presence of neglect. These findings support the view that two different pathological mechanisms might be involved in left spatial neglect and ipsilesional perseverative behavior.

  20. Animal brucellosis in Egypt.

    Science.gov (United States)

    Wareth, Gamal; Hikal, Ahmed; Refai, Mohamed; Melzer, Falk; Roesler, Uwe; Neubauer, Heinrich

    2014-11-13

    Brucellosis is a highly contagious zoonosis that affects the public health and economic performance of endemic as well as non-endemic countries. In developing nations, brucellosis is often a very common but neglected disease. The purpose of this review is to provide insight about brucellosis in animal populations in Egypt and help to understand the situation from 1986 to 2013. A total of 67 national and international scientific publications on serological investigations, isolation, and biotyping studies from 1986 to 2013 were reviewed to verify the current status of brucellosis in animal populations in Egypt. Serological investigations within the national surveillance program give indirect proof for the presence of brucellosis in cattle, buffaloes, sheep, goats, and camels in Egypt. Serologic testing for brucellosis is a well-established procedure in Egypt, but most of the corresponding studies do not follow the scientific standards. B. melitensis biovar (bv) 3, B. abortus bv 1, and B. suis bv 1 have been isolated from farm animals and Nile catfish. Brucellosis is prevalent nationwide in many farm animal species. There is an obvious discrepancy between official seroprevalence data and data from scientific publications. The need for a nationwide survey to genotype circulating Brucellae is obvious. The epidemiologic situation of brucellosis in Egypt is unresolved and needs clarification.

  1. Modelling Behaviour

    DEFF Research Database (Denmark)

    2015-01-01

    posing new challenges in all areas of the industry from material and structural to the urban scale. Contributions from invited experts, papers and case studies provide the reader with a comprehensive overview of the field, as well as perspectives from related disciplines, such as computer science....... The chapter authors were invited speakers at the 5th Symposium "Modelling Behaviour", which took place at the CITA in Copenhagen in September 2015....

  2. Parietal rTMS distorts the mental number line: simulating 'spatial' neglect in healthy subjects.

    Science.gov (United States)

    Göbel, Silke M; Calabria, Marco; Farnè, Alessandro; Rossetti, Yves

    2006-01-01

    Patients with left-sided visuospatial neglect, typically after damage to the right parietal lobe, show a systematic bias towards larger numbers when asked to bisect a numerical interval. This has been taken as further evidence for a spatial representation of numbers, perhaps akin to a mental number line with smaller numbers represented to the left and larger numbers to the right. Previously, contralateral neglect-like symptoms in physical line bisection have been induced in healthy subjects with repetitive transcranial magnetic stimulation (rTMS) over right posterior parietal lobe. Here we used rTMS over parietal and occipital sites in healthy subjects to investigate spatial representations in a number bisection task. Subjects were asked to name the midpoint of numerical intervals without calculating. On control trials subjects' behaviour was similar to performance reported in physical line bisection experiments. Subjects underestimated the midpoint of the numerical interval. Repetitive transcranial magnetic stimulation produced representational neglect-like symptoms in number bisection when applied over right posterior parietal cortex (right PPC). Repetitive TMS over right PPC shifted the perceived midpoint of the numerical interval significantly to the right while occipital TMS had no effect on bisection performance. Our study therefore provides further evidence that subjects use spatial representations, perhaps akin to a mental number line, in basic numerical processing tasks. Furthermore, we showed that the right posterior parietal cortex is crucially involved in spatial representation of numbers.

  3. Effects of attentional and cognitive variables on unilateral spatial neglect.

    Science.gov (United States)

    Ricci, Raffaella; Salatino, Adriana; Garbarini, Francesca; Ronga, Irene; Genero, Rosanna; Berti, Anna; Neppi-Mòdona, Marco

    2016-11-01

    Patients with visuospatial neglect when asked to cancel targets partially or totally omit to cancel contralesional stimuli. It has been shown that increasing the attentional demands of the cancellation task aggravates neglect contralesionally. However, some preliminary evidence also suggests that neglect might be worsened by engaging the patient in a demanding, non-spatial, cognitive activity (i.e. a mathematical task). We studied cancellation performance of 16 patients with right-hemisphere lesions, 8 with neglect, 8 without neglect, and 8 age-matched healthy control participants by means of five cancellation tasks which varied for the degree of attentional and/or high level cognitive demands (preattentive and attentive search of a visual target, searching for numbers containing the digit 3, even numbers, and multiples of 3). Results showed that attentive search of visual targets, relative to the preattentive search condition, aggravated neglect patients' performance. Moreover, searching for multiples not only worsened spatial neglect contralesionally, but also slowed down performance of patients with right-hemisphere lesions without neglect. Our findings further demonstrate the presence of specific deficits of attention in neglect. In addition, the worse performance of patients without neglect in the 'multiples of 3' task is consistent with the evidence that right-hemisphere lesions per se impair the ability to maintain attention (i.e. sustained attention). This suggests that the exacerbation of neglect during execution of a demanding, non-spatial, cognitive task might be explained by a deficit of sustained attention in addition to a selective deficit of spatial attention.

  4. Anatomical and psychometric relationships of behavioral neglect in daily living.

    Science.gov (United States)

    Rousseaux, Marc; Allart, Etienne; Bernati, Thérèse; Saj, Arnaud

    2015-04-01

    Spatial neglect has been related to both cortical (predominantly at the temporal-parietal junction) and subcortical (predominantly of the superior longitudinal fasciculus) lesions. The objectives of this observational study were to specify the anatomical relationships of behavioral neglect in activities of daily living (N-ADLs), and the anatomical and psychometric relationships of N-ADLs on one hand and components of neglect (peripersonal neglect and personal neglect) and anosognosia on the other. Forty five patients were analyzed for behavioral difficulties in daily living (on the Catherine Bergego scale) and the main components of neglect (using conventional clinical assessments) during the first months post right hemisphere stroke. Voxel-based lesion-symptom mapping was used to identify brain areas within which lesions explained the severity of bias in each assessment (non-parametric permutation test; p<0.01, one tailed). N-ADLs was associated with lesions centered on the posterior part of the superior temporal gyrus and extending to the temporo-parietal junction, temporo-occipital junction and subcortical white matter (including the superior longitudinal fasciculus). Peripersonal neglect resulted from extended cortical lesions centered on the superior temporal gyrus and the inferior parietal gyrus, with subcortical extension. Personal neglect resulted predominantly from lesions centered on the somatosensory cortex and at a lesser degree on the superior temporal sulcus. Anosognosia resulted from lesions of the posterior inferior temporal gyrus and superior temporal gyrus. In anatomic terms, N-ADLs was strongly related to peripersonal neglect, and those relationships were also shown by the psychometric analysis. In conclusions, superior temporal gyrus and superior longitudinal fasciculus lesions have a pivotal role in N-ADLs. N-ADLs is principally related (anatomically and psychometrically) to peripersonal neglect, and at a lesser degree to anosognosia and

  5. Exploring the interface between diagnostics and maps of neglected parasitic diseases.

    Science.gov (United States)

    Rinaldi, Laura; Cringoli, Giuseppe

    2014-12-01

    Although not new, the 'One Health' concept is gaining progressively more importance in parasitology. Now more than ever, veterinary and human perspectives should be closely joined in diagnosis and surveillance of neglected parasitic diseases. We argue that concerted, standardized and harmonized diagnostic and surveillance strategies are needed for the control and/or elimination of animal and human neglected parasitic infections. A key challenge is to integrate parasitological data with available geospatial methods in an accessible and user-friendly framework. We discuss the capability of new diagnostic devices (e.g. Mini-FLOTAC) and geospatial technologies supported by mobile- and electronic-based approaches as one of the research priorities of the new millennium.

  6. Animal Bites

    Science.gov (United States)

    ... or territory. Attacks by pets are more common. Animal bites rarely are life-threatening, but if they become infected, you can develop serious medical problems. To prevent animal bites and complications from bites Never pet, handle, ...

  7. Animal Farm

    Institute of Scientific and Technical Information of China (English)

    徐蓉蓉

    2015-01-01

    This essay first introduce the background of Animal Farm and a brief introduction of the author.Then it discuss three thesis about this novel and briefly discussed about it.At last it give highly review on Animal Farm.

  8. Microstructural damage of the posterior corpus callosum contributes to the clinical severity of neglect.

    Directory of Open Access Journals (Sweden)

    Marco Bozzali

    Full Text Available One theory to account for neglect symptoms in patients with right focal damage invokes a release of inhibition of the right parietal cortex over the left parieto-frontal circuits, by disconnection mechanism. This theory is supported by transcranial magnetic stimulation studies showing the existence of asymmetric inhibitory interactions between the left and right posterior parietal cortex, with a right hemispheric advantage. These inhibitory mechanisms are mediated by direct transcallosal projections located in the posterior portions of the corpus callosum. The current study, using diffusion imaging and tract-based spatial statistics (TBSS, aims at assessing, in a data-driven fashion, the contribution of structural disconnection between hemispheres in determining the presence and severity of neglect. Eleven patients with right acute stroke and 11 healthy matched controls underwent MRI at 3T, including diffusion imaging, and T1-weighted volumes. TBSS was modified to account for the presence of the lesion and used to assess the presence and extension of changes in diffusion indices of microscopic white matter integrity in the left hemisphere of patients compared to controls, and to investigate, by correlation analysis, whether this damage might account for the presence and severity of patients' neglect, as assessed by the Behavioural Inattention Test (BIT. None of the patients had any macroscopic abnormality in the left hemisphere; however, 3 cases were discarded due to image artefacts in the MRI data. Conversely, TBSS analysis revealed widespread changes in diffusion indices in most of their left hemisphere tracts, with a predominant involvement of the corpus callosum and its projections on the parietal white matter. A region of association between patients' scores at BIT and brain FA values was found in the posterior part of the corpus callosum. This study strongly supports the hypothesis of a major role of structural disconnection between the

  9. Intervention Strategies for School Counselors in Child Abuse and Neglect.

    Science.gov (United States)

    Faller, Kathleen

    School counselors and school personnel have a vital role in three areas of suspected child abuse and neglect: (1) as frontline professionals in the process of identification; (2) as persons required to report suspected abuse or neglect; and (3) as contributors to the treatment process. Signs of child maltreatment are described with reference to…

  10. Attachment Styles and Aggression in Physically Abused and Neglected Children.

    Science.gov (United States)

    Finzi, Ricky; Ram, Anca; Har-Even, Dov; Shnit, Dan; Weizman, Abraham

    2001-01-01

    Compared physically abused (n=41) and neglected (n=38) children with nonabused, nonneglected children (n=35) aged 6 to 12 years in terms of their attachment styles and their levels of aggression. Findings show that physically abused children are at risk of antisocial behavior and suspicion toward others, and neglected children are at risk of…

  11. Familial Correlates of Selected Types of Child Abuse and Neglect.

    Science.gov (United States)

    Martin, Michael J.; Walters, James

    1982-01-01

    Studied 489 cases of child abuse and neglect to determine specific patterns of family circumstance which tended to be present in families in which abandonment, physical abuse, emotional abuse, neglect, or sexual abuse had been substantiated. Findings indicated that different kinds of abuse are related to different antecedent variables. (Author)

  12. Motor Response Deficits of Unilateral Neglect: Assessment, Therapy, and Neuroanatomy.

    Science.gov (United States)

    Saevarsson, Styrmir

    2013-04-16

    The clinical impact of the motor deficits of unilateral neglect is indisputable. The diagnosis criteria are confusing and complicated, and assessment has been extended and modified gradually during the last few decades, which has led to inconsistency and confusion. Many different attempts have been made to overcome various assessment shortcomings. In this article, different examinations of previous studies and analyses are discussed in a systematic and critical way. Research databases were used to identify 254 reports, including 26 different empirical studies on motor neglect and 44 studies on premotor neglect. Most of the studies address the gross neuroanatomical location of lesions. The main findings indicate that frontal lesions are more common in motor neglect than in premotor neglect, and parietal lesions are more common in premotor neglect than in motor neglect. Few studies have evaluated therapeutic programs for the motor deficits of neglect. Unfortunately, most studies suffer from various diagnostic problems that result in inconsistent and controversial findings. Different assessment issues need to be addressed systematically in future studies in light of current findings to increase our understanding and awareness of these important neuropsychological motor deficits. Implications of and possible solutions to the current assessment shortcomings are discussed.

  13. Adolescent Neglect, Juvenile Delinquency and the Risk of Recidivism

    Science.gov (United States)

    Ryan, Joseph P.; Williams, Abigail B.; Courtney, Mark E.

    2013-01-01

    Victims of child abuse and neglect are at an increased risk of involvement with the juvenile justice and adult correctional systems. Yet, little is known about the continuation and trajectories of offending beyond initial contact with law enforcement. Neglect likely plays a critical role in continued offending as parental monitoring, parental…

  14. Reflection a neglected art in health promotion.

    Science.gov (United States)

    Fleming, Paul

    2007-10-01

    Evaluation and quality assurance have, over time, become the bedrock of health promotion practice in ensuring effectiveness and efficiency of programme planning and delivery. There has been less emphasis, however, on formal recognition of the contribution of the personal characteristics and perspectives of those who plan and deliver programmes and to the more subtle underlying effects of prevailing societal and professional norms. This paper seeks to highlight the neglect of formal reflection as a key professional skill in professional health promotion practice. It outlines key theories underpinning the development of the concepts of reflection and reflective practice. The role of reflection in critical health education as it contributes to critical consciousness raising is highlighted through its contribution to the empowerment of change agents in a societal change context. A conceptual typology of reflective practice is described which provides a flexible structure with which professionals can reflect on the role of self, the context and the process of health promotion programme planning. Its use is illustrated from the author's published work in health promotion which is related to prevention of workplace violence.

  15. Animal models

    DEFF Research Database (Denmark)

    Gøtze, Jens Peter; Krentz, Andrew

    2014-01-01

    In this issue of Cardiovascular Endocrinology, we are proud to present a broad and dedicated spectrum of reviews on animal models in cardiovascular disease. The reviews cover most aspects of animal models in science from basic differences and similarities between small animals and the human...... pathology, to biomarkers in diagnosis and prognostic evaluation, to drug testing and targeted medicine....

  16. Animal Deliberation

    NARCIS (Netherlands)

    Driessen, C.P.G.

    2014-01-01

    While much has been written on environmental politics on the one hand, and animal ethics and welfare on the other, animal politics, as the interface of the two, is underexamined. There are key political implications in the increase of animal protection laws, the rights of nature, and political parti

  17. Elder Abuse and Neglect in Turkey: A Systematic Review

    Directory of Open Access Journals (Sweden)

    Neslihan Lok

    2015-06-01

    Full Text Available Along with a growing elderly population in the world and in our country, elder abuse and neglect has been a major problem. The purpose of this study is to identify and systematically review the studies investigating elder abuse and neglect in Turkey. Evaluation of the studies on elder abuse and neglect in Turkey showed that the elderly are often abused by family members and they are often exposed to emotional, physical, economic and psychological abuse. All of the studies reviewed in this paper were descriptive cross-sectional studies investigating elder abuse and neglect. The studies reviewed presented significant results revealing the prevalence of elder abuse and neglect in Turkey. In conclusion, this systematic review revealed that research on this issue in Turkey is insufficient and there is a need for studies conducted with larger samples covering an entire city. [Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry 2015; 7(2: 149-156

  18. Effects of percutaneous needle liver biopsy on dairy cow behaviour

    DEFF Research Database (Denmark)

    Mølgaard, Lene; Damgaard, Birthe Marie; Bjerre-Harpøth, Vibeke;

    2012-01-01

    behavioural changes for up to 19 h – and particularly for behaviour previously associated with pain. Even though the exact welfare impact of percutaneous needle liver biopsies in cows is not known, and the magnitude of the behavioural changes was limited, pain always has negative effects on animal welfare...

  19. Pain in aquatic animals.

    Science.gov (United States)

    Sneddon, Lynne U

    2015-04-01

    Recent developments in the study of pain in animals have demonstrated the potential for pain perception in a variety of wholly aquatic species such as molluscs, crustaceans and fish. This allows us to gain insight into how the ecological pressures and differential life history of living in a watery medium can yield novel data that inform the comparative physiology and evolution of pain. Nociception is the simple detection of potentially painful stimuli usually accompanied by a reflex withdrawal response, and nociceptors have been found in aquatic invertebrates such as the sea slug Aplysia. It would seem adaptive to have a warning system that allows animals to avoid life-threatening injury, yet debate does still continue over the capacity for non-mammalian species to experience the discomfort or suffering that is a key component of pain rather than a nociceptive reflex. Contemporary studies over the last 10 years have demonstrated that bony fish possess nociceptors that are similar to those in mammals; that they demonstrate pain-related changes in physiology and behaviour that are reduced by painkillers; that they exhibit higher brain activity when painfully stimulated; and that pain is more important than showing fear or anti-predator behaviour in bony fish. The neurophysiological basis of nociception or pain in fish is demonstrably similar to that in mammals. Pain perception in invertebrates is more controversial as they lack the vertebrate brain, yet recent research evidence confirms that there are behavioural changes in response to potentially painful events. This review will assess the field of pain perception in aquatic species, focusing on fish and selected invertebrate groups to interpret how research findings can inform our understanding of the physiology and evolution of pain. Further, if we accept these animals may be capable of experiencing the negative experience of pain, then the wider implications of human use of these animals should be considered.

  20. Development and Psychometric Evaluation of the Child Neglect Questionnaire.

    Science.gov (United States)

    Stewart, Chris; Kirisci, Levent; Long, Abigail L; Giancola, Peter R

    2015-11-01

    Neglect poses a significant risk for children throughout their development and is often linked with serious consequences that reach into adulthood. The Child Neglect Questionnaire (CNQ) fills existing gaps by incorporating multiple perspectives from both parents and the child, as well as measuring the complex phenomenon of neglect multidimensionally. Furthermore, this measure addresses the need for an instrument specifically developed for late childhood (ages 10-12), as much of the extant evidence and corresponding measures focus on young children and their mothers. A panel of three psychologists, using Cicchetti's model of child neglect as a theoretical guide, began by selecting items from an existing database. Results of exploratory and confirmatory factor analyses and item response theory demonstrated the unidimensionality of physical, emotional, educational, and supervision neglect as well as a second-order construct of child neglect. Analyses controlling for risk status due to father's substance use disorder, socioeconomic status, and child's ethnicity demonstrated that father's and mother's (parental) neglect, particularly in the child's versions, had sound concurrent and predictive validity. Concurrently, at age 10-12, the child's version of both parents' neglect correlated with their parenting behaviors evaluated by other available measures. Prospectively, from 10-12 years of age to 11-13 years of age, parental neglect predicted child's drug use frequency with coexisting psychological dysregulation, psychiatric symptoms, antisocial behavior, non-normative sexual behavior, involvement with deviant peers and leisure activities thus demonstrating sound predictive validity. Also, internal consistency and inter-rater reliability were excellent. The CNQ, particularly the child's version, may thus be useful for detecting children at high risk for parental neglect.

  1. Entry, Descent, Landing Animation (Animation)

    Science.gov (United States)

    2005-01-01

    [figure removed for brevity, see original site] Click on the image for Entry, Descent, Landing animation This animation illustrates the path the Stardust return capsule will follow once it enters Earth's atmosphere.

  2. Collective behaviour and swarm intelligence in slime moulds.

    Science.gov (United States)

    Reid, Chris R; Latty, Tanya

    2016-08-29

    The study of collective behaviour aims to understand how individual-level behaviours can lead to complex group-level patterns. Collective behaviour has primarily been studied in animal groups such as colonies of insects, flocks of birds and schools of fish. Although less studied, collective behaviour also occurs in microorganisms. Here, we argue that slime moulds are powerful model systems for solving several outstanding questions in collective behaviour. In particular, slime mould may hold the key to linking individual-level mechanisms to colony-level behaviours. Using well-established principles of collective animal behaviour as a framework, we discuss the extent to which slime mould collectives are comparable to animal groups, and we highlight some potentially fruitful areas for future research.

  3. (Un)awareness of unilateral spatial neglect: a quantitative evaluation of performance in visuo-spatial tasks.

    Science.gov (United States)

    Ronchi, Roberta; Bolognini, Nadia; Gallucci, Marcello; Chiapella, Laura; Algeri, Lorella; Spada, Maria Simonetta; Vallar, Giuseppe

    2014-12-01

    Right-brain-damaged patients with unilateral spatial neglect are usually unaware (anosognosic) about their spatial deficits. However, in the scientific literature there is a lack of systematic and quantitative evaluation of this kind of unawareness, despite the negative impact of anosognosia on rehabilitation programs. This study investigated anosognosia for neglect-related impairments at different clinical tasks, by means of a quantitative assessment. Patients were tested in two different conditions (before and after execution of each task), in order to evaluate changes in the level of awareness of neglect-related behaviours triggered by task execution. Twenty-nine right-brain-damaged patients (17 with left spatial neglect) and 27 neurologically unimpaired controls entered the study. Anosognosia for spatial deficits is not pervasive, with different tasks evoking different degrees of awareness about neglect symptoms. Indeed, patients showed a largely preserved awareness about their performance in complex visuo-motor spatial and reading tasks; conversely, they were impaired in evaluating their spatial difficulties in line bisection and drawing from memory, showing over-estimation of their performance. The selectivity of the patients' unawareness of specific manifestations of spatial neglect is further supported by their preserved awareness of performance at a linguistic task, and by the absence of anosognosia for hemiplegia. This evidence indicates that discrete processes are involved in the aware monitoring of cognitive and motor performance, which can be selectively compromised by brain damage. Awareness of spatial difficulties is supported by a number of distinct components, and influenced by the specific skills required to perform a given task.

  4. Reviewing dengue: still a neglected tropical disease?

    Directory of Open Access Journals (Sweden)

    Olaf Horstick

    2015-04-01

    Full Text Available Dengue is currently listed as a "neglected tropical disease" (NTD. But is dengue still an NTD or not? Classifying dengue as an NTD may carry advantages, but is it justified? This review considers the criteria for the definition of an NTD, the current diverse lists of NTDs by different stakeholders, and the commonalities and differences of dengue with other NTDs. We also review the current research gaps and research activities and the adequacy of funding for dengue research and development (R&D (2003-2013. NTD definitions have been developed to a higher precision since the early 2000s, with the following main features: NTDs are characterised as a poverty related, b endemic to the tropics and subtropics, c lacking public health attention, d having poor research funding and shortcomings in R&D, e usually associated with high morbidity but low mortality, and f often having no specific treatment available. Dengue meets most of these criteria, but not all. Although dengue predominantly affects resource-limited countries, it does not necessarily only target the poor and marginalised in those countries. Dengue increasingly attracts public health attention, and in some affected countries it is now a high profile disease. Research funding for dengue has increased exponentially in the past two decades, in particular in the area of dengue vaccine development. However, despite advances in dengue research, dengue epidemics are increasing in frequency and magnitude, and dengue is expanding to new areas. Specific treatment and a highly effective vaccine remain elusive. Major research gaps exist in the area of integrated surveillance and vector control. Hence, although dengue differs from many of the NTDs, it still meets important criteria commonly used for NTDs. The current need for increased R&D spending, shared by dengue and other NTDs, is perhaps the key reason why dengue should continue to be considered an NTD.

  5. Neglected tropical diseases outside the tropics.

    Directory of Open Access Journals (Sweden)

    Francesca F Norman

    Full Text Available BACKGROUND: The neglected tropical diseases (NTDs cause significant morbidity and mortality worldwide. Due to the growth in international travel and immigration, NTDs may be diagnosed in countries of the western world, but there has been no specific focus in the literature on imported NTDs. METHODS: Retrospective study of a cohort of immigrants and travelers diagnosed with one of the 13 core NTDs at a Tropical Medicine Referral Unit in Spain during the period April 1989-December 2007. Area of origin or travel was recorded and analyzed. RESULTS: There were 6168 patients (2634 immigrants, 3277 travelers and 257 VFR travelers in the cohort. NTDs occurred more frequently in immigrants, followed by VFR travelers and then by other travelers (p<0.001 for trend. The main NTDs diagnosed in immigrants were onchocerciasis (n = 240, 9.1% acquired mainly in sub-Saharan Africa, Chagas disease (n = 95, 3.6% in immigrants from South America, and ascariasis (n = 86, 3.3% found mainly in immigrants from sub-Saharan Africa. Most frequent NTDs in travelers were: schistosomiasis (n = 43, 1.3%, onchocerciasis (n = 17, 0.5% and ascariasis (n = 16, 0.5%, and all were mainly acquired in sub-Saharan Africa. The main NTDs diagnosed in VFR travelers were onchocerciasis (n = 14, 5.4%, and schistosomiasis (n = 2, 0.8%. CONCLUSIONS: The concept of imported NTDs is emerging as these infections acquire a more public profile. Specific issues such as the possibility of non-vectorial transmission outside endemic areas and how some eradication programmes in endemic countries may have an impact even in non-tropical western countries are addressed. Recognising NTDs even outside tropical settings would allow specific prevention and control measures to be implemented and may create unique opportunities for research in future.

  6. Conservation physiology of animal migration.

    Science.gov (United States)

    Lennox, Robert J; Chapman, Jacqueline M; Souliere, Christopher M; Tudorache, Christian; Wikelski, Martin; Metcalfe, Julian D; Cooke, Steven J

    2016-01-01

    Migration is a widespread phenomenon among many taxa. This complex behaviour enables animals to exploit many temporally productive and spatially discrete habitats to accrue various fitness benefits (e.g. growth, reproduction, predator avoidance). Human activities and global environmental change represent potential threats to migrating animals (from individuals to species), and research is underway to understand mechanisms that control migration and how migration responds to modern challenges. Focusing on behavioural and physiological aspects of migration can help to provide better understanding, management and conservation of migratory populations. Here, we highlight different physiological, behavioural and biomechanical aspects of animal migration that will help us to understand how migratory animals interact with current and future anthropogenic threats. We are in the early stages of a changing planet, and our understanding of how physiology is linked to the persistence of migratory animals is still developing; therefore, we regard the following questions as being central to the conservation physiology of animal migrations. Will climate change influence the energetic costs of migration? Will shifting temperatures change the annual clocks of migrating animals? Will anthropogenic influences have an effect on orientation during migration? Will increased anthropogenic alteration of migration stopover sites/migration corridors affect the stress physiology of migrating animals? Can physiological knowledge be used to identify strategies for facilitating the movement of animals? Our synthesis reveals that given the inherent challenges of migration, additional stressors derived from altered environments (e.g. climate change, physical habitat alteration, light pollution) or interaction with human infrastructure (e.g. wind or hydrokinetic turbines, dams) or activities (e.g. fisheries) could lead to long-term changes to migratory phenotypes. However, uncertainty remains

  7. Identification & Registration of Marine Animals (IRMA)

    NARCIS (Netherlands)

    Benders, F.P.A.; Zwan, T. van der; Verboom, W.C.

    2005-01-01

    Knowledge about habitats and behaviour of marine animals has become more important following an increased concern that acoustic sources may have an influence on marine life. Databases containing the habitats and behaviour are being filled all over the world. However, at present marine mammal watcher

  8. Modelling Behaviour

    DEFF Research Database (Denmark)

    2015-01-01

    This book reflects and expands on the current trend in the building industry to understand, simulate and ultimately design buildings by taking into consideration the interlinked elements and forces that act on them. This approach overcomes the traditional, exclusive focus on building tasks, while....... The chapter authors were invited speakers at the 5th Symposium "Modelling Behaviour", which took place at the CITA in Copenhagen in September 2015....... posing new challenges in all areas of the industry from material and structural to the urban scale. Contributions from invited experts, papers and case studies provide the reader with a comprehensive overview of the field, as well as perspectives from related disciplines, such as computer science...

  9. Factors Affecting the Clinical Measurement of Visuo-Spatial Neglect

    Directory of Open Access Journals (Sweden)

    L. Pizzamiglio

    1992-01-01

    Full Text Available The present study examined a battery of tests to evaluate unilateral spatial neglect; the tests included different tasks involving several modalities of spatial exploration mapping perceptual, motor, attentional and personal or extrapersonal space dimensions. The subjects, 121 right-brain-damaged patients with unilateral neglect, were studied in seven laboratories in four European countries. Relationships among the various tests were examined by correlations, a cluster analysis and by an analysis of individual cases. Different sensitivity was found among various tests for detecting neglect performances. Both the cluster analysis and the single case analysis clearly showed a segregation between personal and extrapersonal neglect. Analysis of the large cluster, including a variety of tests of extra personal neglect, together with the study of single cases, suggests the possibility of differentiating the various manifestations of spatial neglect which can be interpreted on the basis of the descriptions of other individual cases previously reported in the literature. Finally, the present study indicated the relative stability of neglect following the acute phase and its independence from age.

  10. Linking behavioural syndromes and cognition: a behavioural ecology perspective.

    Science.gov (United States)

    Sih, Andrew; Del Giudice, Marco

    2012-10-01

    With the exception of a few model species, individual differences in cognition remain relatively unstudied in non-human animals. One intriguing possibility is that variation in cognition is functionally related to variation in personality. Here, we review some examples and present hypotheses on relationships between personality (or behavioural syndromes) and individual differences in cognitive style. Our hypotheses are based largely on a connection between fast-slow behavioural types (BTs; e.g. boldness, aggressiveness, exploration tendency) and cognitive speed-accuracy trade-offs. We also discuss connections between BTs, cognition and ecologically important aspects of decision-making, including sampling, impulsivity, risk sensitivity and choosiness. Finally, we introduce the notion of cognition syndromes, and apply ideas from theories on adaptive behavioural syndromes to generate predictions on cognition syndromes.

  11. Natural selection and animal personality

    NARCIS (Netherlands)

    Dingemanse, NJ; Reale, D

    2005-01-01

    Recent progress has been made on the study of personality in animals, both from a mechanistic and a functional perspective. While we start knowing more about the proximal mechanisms responsible for the consistent differences in behaviour between individuals in a population, little is known yet about

  12. Animal Shelter

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Beijing activist Zhang Luping gives up a lucrative business career to provide a home for stray and abandoned pets "I have never been married, but I have I hundreds of children," said Zhang Luping, founder of the Beijing Human and Animal Environment Education Center (the Animal Center). "God sent me to this planet and gave me the mission of taking care of helpless and homeless dogs and cats. I will never let Him down." The Animal Center, one of a few non-

  13. Statistical learning as a tool for rehabilitation in spatial neglect.

    Directory of Open Access Journals (Sweden)

    Albulena eShaqiri

    2013-05-01

    Full Text Available We propose that neglect includes a disorder of representational updating. Representational updating refers to our ability to build mental models and adapt those models to changing experience. This updating ability depends on the processes of priming, working memory, and statistical learning. These processes in turn interact with our capabilities for sustained attention and precise temporal processing. We review evidence showing that all these non-spatial abilities are impaired in neglect, and we discuss how recognition of such deficits can lead to novel approaches for rehabilitating neglect.

  14. Integrated dataset of screening hits against multiple neglected disease pathogens.

    Directory of Open Access Journals (Sweden)

    Solomon Nwaka

    2011-12-01

    Full Text Available New chemical entities are desperately needed that overcome the limitations of existing drugs for neglected diseases. Screening a diverse library of 10,000 drug-like compounds against 7 neglected disease pathogens resulted in an integrated dataset of 744 hits. We discuss the prioritization of these hits for each pathogen and the strong correlation observed between compounds active against more than two pathogens and mammalian cell toxicity. Our work suggests that the efficiency of early drug discovery for neglected diseases can be enhanced through a collaborative, multi-pathogen approach.

  15. Missed cases of multiple forms of child abuse and neglect.

    Science.gov (United States)

    Koc, Feyza; Oral, Resmiye; Butteris, Regina

    2014-01-01

    Child abuse and neglect is a public health problem and usually associated with family dysfunction due to multiple psychosocial, individual, and environmental factors. The diagnosis of child abuse may be difficult and require a high index of suspicion on the part of the practitioners encountering the child and the family. System-related factors may also enable abuse or prevent the early recognition of abuse. Child abuse and neglect that goes undiagnosed may give rise to chronic abuse and increased morbidity-mortality. In this report, we present two siblings who missed early diagnosis and we emphasize the importance of systems issues to allow early recognition of child abuse and neglect.

  16. Animal ethics

    DEFF Research Database (Denmark)

    Palmer, Clare; Sandøe, Peter

    2011-01-01

    This chapter describes and discusses different views concerning our duties towards animals. First, we explain why it is necessary to engage in thinking about animal ethics and why it is not enough to rely on feelings alone. Secondly, we present and discuss five different kinds of views about...... the nature of our duties to animals. They are: contractarianism, utilitarianism, the animal rights view, contextual views, and a respect for nature view. Finally, we briefly consider whether it is possible to combine elements from the presented views, and how to make up one’s mind....

  17. Animated Asphalt

    DEFF Research Database (Denmark)

    Paldam, Camilla Skovbjerg

    2015-01-01

    “animation”, defined as “an innate (and learnable) ability of our bodies to discover life in inanimate images” (Belting 2012, 188). In this essay I investigate the animation of pictures in dialogue with Mitchell, both by addressing general questions such as: how is animation of otherwise static pictures...... to be understood? How does animation differ in different media? And in particular by focusing on and questioning the gender positions inherent in Mitchell’s theory. Animation has an erotic component of seduction and desire, and what pictures want, becomes for Mitchell, what women want. There is of course no simple...

  18. The Relationship between Bullying and Animal Abuse Behaviors in Adolescents: The Importance of Witnessing Animal Abuse

    Science.gov (United States)

    Gullone, Eleonora; Robertson, Nerida

    2008-01-01

    Children's abuse of animals may be predictive of aggression towards humans. This study assessed concurrent engagement in animal abuse and bullying behaviour in 241 adolescents aged 12 to 16 years. A total of 20.6% of youths reported abusing animals at least "sometimes" and 17.8% reported bullying others on at least one occasion in the past year.…

  19. Have agricultural economists neglected poverty issues?

    Science.gov (United States)

    Thiesenhusen, W C

    1991-01-01

    Agricultural economists concerned with development issues devote effort to researching agriculture's inputs to produce a surplus and transfer it to nonagriculture, to provide markets for urban-based industry, to maintain a labor reservoir, to assist in capital formation, and to accumulate foreign exchange. Little attention is focused on broader and more sweeping economic problems. Discussion is directed toward answering some questions about why agricultural economists neglect rural poverty. Also, attention is given to why the extent of rural poverty imperils development, in what location should poverty be addressed, what are the issues in the agricultural growth and inequality debate as it affects rural poverty, and whether there are any new or promising ways to combat rural poverty. The extent of poverty is measured by the World Bank as 20% of world population, or 1 billion people, Rural poverty accounts for 60% of the hungry poor in Latin America, 80% in Asia, and 90% in Africa. 11 items are used to define the rural poor, such as a heterogeneous population of primarily small-scale farmers, the landless, nomads, pastoralists, and fisherfolk. 5 reasons are given why economists avoid rural poverty, including the difficulty in modeling the complex problems of rural poverty and the political considerations of free market vs. socialist economies. Other reasons involve land reform which reduces labor needs and a commitment to commercial farming rather than small-scale, labor-intensive farming; the rural agricultural poor's contributions to development are underrated. East Asian countries have been successful in linking growth, distribution, and amelioration of poverty among the peasantry. Environmental degradation may be encouraged by inequalities and unequal access to resources. The example is given of Brazil which has promoted migration to cities due to commercialization of rural agriculture and created urban poverty instead of dealing directly with rural poverty by

  20. Animal welfare: the EU policy and consumers' perspectives

    OpenAIRE

    2011-01-01

    The awareness of animal welfare and animal well-being is growing all over Europe and the world. The concerns are related to the applied policy regimes, economic sustainability of the production methods, food quality and safety, consumers’ health and behaviour and their willingness to pay for animal products obtained in animal-friendly conditions. The paper aims to analyse the consumers’ awareness and its effect on consumers’ purchasing behaviour in Bulgaria. The data were collected under the ...

  1. Neglected diseases of neglected populations: Thinking to reshape the determinants of health in Latin America and the Caribbean

    Directory of Open Access Journals (Sweden)

    Ault Steven K

    2005-11-01

    Full Text Available Abstract Background People living in poverty throughout the developing world are heavily burdened with neglected communicable diseases and often marginalized by the health sector. These diseases are currently referred to as Neglected Diseases of Neglected Populations. The neglected diseases create social and financial burdens to the individual, the family, the community, and the nation. Discussion Numerous studies of successful individual interventions to manage communicable disease determinants in various types of communities have been published, but few have applied multiple interventions in an integrated, coordinated manner. We have identified a series of successful interventions and developed three hypothetical scenarios where such interventions could be applied in an integrated, multi-disease, inter-programmatic, and/or inter-sectoral approach for prevention and control of neglected diseases in three different populations: a slum, an indigenous community, and a city with a mix of populations. Summary The objective of this paper is to identify new opportunities to address neglected diseases, improve community health and promote sustainable development in neglected populations by highlighting examples of key risk and protective factors for neglected diseases which can be managed and implemented through multi-disease-based, integrated, inter-programmatic, and/or inter-sectoral approaches. Based on a literature review, analysis and development of scenarios we visualize how multiple interventions could manage multiple disease problems and propose these as possible strategies to be tested. We seek to stimulate intra- and inter-sectoral dialogue which will help in the construction of new strategies for neglected diseases (particularly for the parasitic diseases which could benefit the poor and marginalized based on the principle of sustainability and understanding of key determinants of health, and lead to the establishment of pilot projects and

  2. Kindergarten Animation

    Science.gov (United States)

    Hinshaw, Craig

    2012-01-01

    Animation is one of the last lessons that come to mind when thinking of kindergarten art. The necessary understanding of sequencing, attention to small, often detailed drawings, and the use of technology all seem more suitable to upper elementary. With today's emphasis on condensing and integrating curriculum, consider developing animation lessons…

  3. Animal Detectives

    Science.gov (United States)

    Mulvey, Bridget; Warnock, Carly

    2015-01-01

    During a two-week inquiry-based 5E learning cycle unit, children made observations and inferences to guide their explorations of animal traits and habitats (Bybee 2014). The children became "animal detectives" by studying a live-feed webcam and digital images of wolves in their natural habitat, reading books and online sources about…

  4. Animal ethics

    DEFF Research Database (Denmark)

    Palmer, Clare; Sandøe, Peter

    2011-01-01

    This chapter describes and discusses different views concerning our duties towards animals. First, we explain why it is necessary to engage in thinking about animal ethics and why it is not enough to rely on feelings alone. Secondly, we present and discuss five different kinds of views about...

  5. National Child Abuse and Neglect Data System (NCANDS) Child File

    Data.gov (United States)

    U.S. Department of Health & Human Services — The National Child Abuse and Neglect Data System (NCANDS) Child File data set consists of child-specific data of all reports of maltreatment to State child...

  6. Brazil's neglected tropical diseases: an overview and a report card.

    Science.gov (United States)

    Hotez, Peter J; Fujiwara, Ricardo T

    2014-08-01

    Today, the nation of Brazil leads the Western Hemisphere in terms of the number of its citizens living with neglected tropical diseases (NTDs). These diseases continue to trap Brazil's "bottom 20 million" in extreme poverty.

  7. Perceptual asymmetries and handedness: A neglected link?

    Directory of Open Access Journals (Sweden)

    Daniele eMarzoli

    2014-02-01

    Full Text Available Healthy individuals tend to weigh in more the left than the right side of visual space in a variety of contexts, ranging from pseudoneglect to perceptual asymmetries for faces. Among the common explanations proposed for the attentional and perceptual advantages of the left visual field, a link with the prevalence of right-handedness in humans has never been suggested, although some evidence seems to converge in favor of a bias of spatial attention towards the region most likely coincident with another person’s right hand during a face-to-face interaction. Such a bias might imply an increased efficiency in monitoring both communicative and aggressive acts, the right limb being more used than the left in both types of behaviour. Although attentional and perceptual asymmetries could be linked to right-handedness at the level of phylogeny because of the evolutionarily advantage of directing attention towards the region where others’ dominant hand usually operates, it is also legitimate to question whether, at the ontogenetic level, frequent exposure to right-handed individuals may foster leftward biases. These views are discussed in the light of extant literature, and a number of tests are proposed in order to assess our hypotheses.

  8. Right-hemisphere (spatial?) acalculia and the influence of neglect

    OpenAIRE

    Silvia eBenavides-Varela; Marco ePitteri; Konstantinos ePriftis; Laura ePassarini; Francesca eMeneghello; Carlo eSemenza

    2014-01-01

    The present study aimed at exploring basic number and calculation abilities in right-hemisphere damaged patients (RHD), focusing primarily on one-digit orally presented tasks, which do not require explicit visuo-spatial abilities. Twenty-four non mentally-deteriorated RHD patients [12 with clinical neglect (RHDN+), 12 without clinical neglect (RHDN−)], and 12 healthy controls were included in the study. Participants were administered an ad hoc numerical battery assessing abilities such as cou...

  9. Neglected diseases amid wealth in the United States and Europe.

    Science.gov (United States)

    Hotez, Peter

    2009-01-01

    Neglected tropical diseases are not exclusive to low-income countries. In the United States, such infections account for a sizable but largely hidden disease burden among minority populations living in poverty and among people of African descent in particular. Similar infections also occur in Europe. As efforts to control neglected tropical diseases expand throughout Africa, parallel efforts should also target poor and forgotten people in wealthy nations.

  10. Noma: neglected, forgotten and a human rights issue.

    Science.gov (United States)

    Leila Srour, M; Marck, Klaas W; Baratti-Mayer, Denise

    2015-05-01

    Noma, an orofacial gangrene and opportunistic infection, affects primarily malnourished children living in extreme poverty. Neglected, forgotten, unknown by most health workers, noma results in death, disfigurement and disability of some of the world's most vulnerable children. Noma is a biological indicator of multiple human rights violations, including the right to food. International support and national attention in countries with noma are lacking. The end of neglect of noma can lead to the elimination of this horrific childhood disease.

  11. Walking and wheelchair navigation in patients with left visual neglect.

    Science.gov (United States)

    Turton, Ailie J; Dewar, Sophie J; Lievesley, Alex; O'Leary, Kelly; Gabb, Jude; Gilchrist, Iain D

    2009-04-01

    Patients with neglect veer to one side when walking or driving a wheelchair, however there is a contradiction in the literature about the direction of this deviation. The study investigated the navigational trajectory of a sample of neglect patients of mixed mobility status in an ecological setting. Fifteen patients with left-sided neglect after right hemisphere stroke were recorded walking or driving a powered wheelchair along a stretch of corridor. Their position in the corridor and the number of collisions was recorded. The results showed that the patients' path was dependent on their mobility status: wheelchair patients with neglect consistently deviated to the left of the centre of the corridor and walking patients with neglect consistently deviated to the right. A further two ambulant patients with neglect were recorded both walking and using the wheelchair to determine whether the differences were task or patient dependent. These two patients also exhibited leftward deviation when driving the wheelchair, but a rightward deviation when walking. These results suggest that the direction of the deviation is task dependent. Further work will be required to identify what features of the two modes of navigation lead to this dissociation.

  12. Combining language and space: sentence bisection in unilateral spatial neglect.

    Science.gov (United States)

    Veronelli, Laura; Guasti, Maria T; Arduino, Lisa S; Vallar, Giuseppe

    2014-10-01

    In line bisection right-brain-damaged patients with left spatial neglect show a rightward deviation, with respect to the line's physical center. In word bisection ortho-phonological features of the stimulus' final (right-sided) part modulate performance of both patients and healthy participants (Veronelli, Vallar, Marinelli, Primativo, & Arduino, 2014). We investigated the role of linguistic factors in sentence bisection, in patients with and without neglect, and control participants. The effects of information in the right-sided part of the sentence (Experiment #1), and of lexical and syntactic violations (Experiment #2) were assessed. Neglect patients showed an overall rightward bias, larger than those of patients without neglect and controls. The neglect patients' bias was modulated by stimulus type, decreasing from lines, to letter strings and to all types of sentences. In sum, in visuo-manual sentence bisection a basic linguistic mechanism, such as sentence readability, brings about a more leftward appreciation of the stimulus, reducing the neglect patients' rightward bias.

  13. Electrophysiological responses to affective stimuli in neglectful mothers.

    Science.gov (United States)

    León, Inmaculada; Rodrigo, María José; Quiñones, Ileana; Hernández, Juan Andrés; Lage, Agustín; Padrón, Iván; Bobes, María Antonieta

    2014-01-01

    Results illustrating an atypical neural processing in the early and late differentiation of infant faces have been obtained with neglectful mothers. The present study explores whether a different pattern of response is observed when using non-infant affective pictures. We examined the event-related evoked potentials and induced delta, theta and alpha activity in 14 neglectful mothers and 14 control mothers elicited while categorizing positive, negative and neutral pictures from the International Affective Picture System. Self-reports of anhedonia and empathy were also recorded. Early posterior negativity, P200 and late positive potential components were modulated by the emotional content of pictures in both groups. However, the LPP waveform had a more delayed and more attenuated maximum in neglectful mothers than in control mothers. Oscillatory responses indicated lower power increases for neglectful mothers than for control mothers in delta (1-4 Hz), theta (4-8 Hz) and lower alpha (8-10 Hz) bands at frontal sites, and a more consistent increase for neglectful mothers in theta and lower alpha bands at occipital sites, especially for negative pictures. These findings help us to better understand the limits of emotional insensitivity in neglectful mothers.

  14. Electrophysiological responses to affective stimuli in neglectful mothers.

    Directory of Open Access Journals (Sweden)

    Inmaculada León

    Full Text Available Results illustrating an atypical neural processing in the early and late differentiation of infant faces have been obtained with neglectful mothers. The present study explores whether a different pattern of response is observed when using non-infant affective pictures. We examined the event-related evoked potentials and induced delta, theta and alpha activity in 14 neglectful mothers and 14 control mothers elicited while categorizing positive, negative and neutral pictures from the International Affective Picture System. Self-reports of anhedonia and empathy were also recorded. Early posterior negativity, P200 and late positive potential components were modulated by the emotional content of pictures in both groups. However, the LPP waveform had a more delayed and more attenuated maximum in neglectful mothers than in control mothers. Oscillatory responses indicated lower power increases for neglectful mothers than for control mothers in delta (1-4 Hz, theta (4-8 Hz and lower alpha (8-10 Hz bands at frontal sites, and a more consistent increase for neglectful mothers in theta and lower alpha bands at occipital sites, especially for negative pictures. These findings help us to better understand the limits of emotional insensitivity in neglectful mothers.

  15. Neglect subtypes, race, and poverty: individual, family, and service characteristics.

    Science.gov (United States)

    Jonson-Reid, Melissa; Drake, Brett; Zhou, Pan

    2013-02-01

    Recent child maltreatment research has highlighted the very different context of poverty for Black and White children. Neglect is the most common form of maltreatment and strongly associated with poverty. Neglect is, however, not a unitary construct. We lack an understanding of whether reporting of and responding to different types of neglect may vary by poverty, race, or the intersection of the two. Administrative census, child welfare, welfare, health, and education data were used to examine how family and community poverty factors associate with various subtypes of neglect and subsequent case dispositions for Black and White children. Black children reported to child welfare reside in far poorer communities than Whites, even after taking into account family income (Aid to Families with Dependent Children [AFDC]/Temporary Aid to Needy Families [TANF]). Black children were more commonly reported and substantiated for severe and basic needs neglect. Community poverty indicators had a different relationship to report disposition for Black as compared to White children after controlling for neglect subtypes, child and family characteristics. Implications for practice and policy are discussed.

  16. [Cells of coelomic liquid and cells of different tissues of sea star Asterias rubens L. isolated from intact and post-traumatic animals: behaviour and proliferation under cultivation in vitro].

    Science.gov (United States)

    Sharlaimova, N S; Pinaev, G P; Petukhova, O A

    2010-01-01

    Proposed sources of coelomocytes in Asteroidea after traumatic injures are coelomic epithelium, axial organ or Tidemann's bodies. To study the involvement of cell division in the process, proliferation of cells from different tissues of starfish Asterias rubens L. has been studied after bromdeoxyuridine incorporation in vivo. To study the differentiation of coelomocytes in vitro a method for isolation and cultivation of different tissue cells has been worked out and cell behaviour and proliferation in culture has been analyzed. The reliable BrdU incorporation has been found in coelomic epithelium cells in vivo. Coelomocytes and coelomic epithelium cells behaviour in culture dependent on the post-trauma period after which the cells were loaded into the culture whereas no difference was revealed for axial organ and Tidemann's bodies cells. Two-month cultivation of coelomic epithelium cells resulted in formation of colony-like accumulations of the cells with high nuclear-cytoplasm ratio which of colony-like accumulation of the cells with high nuclear-cytoplasm ratio which incorporated BrdU. Thus, coelomic epithelium cells seem to be more promising object for the study of A. rubens cell differentiation in vitro.

  17. Animal experimentation.

    Science.gov (United States)

    Kolar, Roman

    2006-01-01

    Millions of animals are used every year in often times extremely painful and distressing scientific procedures. Legislation of animal experimentation in modern societies is based on the supposition that this is ethically acceptable when certain more or less defined formal (e.g. logistical, technical) demands and ethical principles are met. The main parameters in this context correspond to the "3Rs" concept as defined by Russel and Burch in 1959, i.e. that all efforts to replace, reduce and refine experiments must be undertaken. The licensing of animal experiments normally requires an ethical evaluation process, often times undertaken by ethics committees. The serious problems in putting this idea into practice include inter alia unclear conditions and standards for ethical decisions, insufficient management of experiments undertaken for specific (e.g. regulatory) purposes, and conflicts of interest of ethics committees' members. There is an ongoing societal debate about ethical issues of animal use in science. Existing EU legislation on animal experimentation for cosmetics testing is an example of both the public will for setting clear limits to animal experiments and the need to further critically examine other fields and aspects of animal experimentation.

  18. Wild Animals

    Institute of Scientific and Technical Information of China (English)

    宁静

    2005-01-01

    Many of us think that all wild animals are dangerous. In fact, very few of them will eat a man if he leaves them alone. If you meet a tiger, I'm sure you will run away, but even a tiger doesn't like meeting a man if it isn't hungry. Tigers only kill and eat man when they are too old to catch their food, such as sheep and other small animals. Some animals get frightened when they only smell a man. Some of themst and and look at a man for a short time before they run away.

  19. Behavioural syndromes differ predictably between 12 populations of three-spined stickleback

    NARCIS (Netherlands)

    Dingemanse, Niels J.; Wright, Jonathan; Kazem, Anahita J. N.; Thomas, Dawn K.; Hickling, Rachael; Dawnay, Nick

    2007-01-01

    1. Animals often differ in suites of correlated behaviours, comparable with how humans differ in personality. Constraints on the architecture of behaviour have been invoked to explain why such 'behavioural syndromes' exist. From an adaptationist viewpoint, however, behavioural syndromes should evolv

  20. Human sparganosis, a neglected food borne zoonosis.

    Science.gov (United States)

    Liu, Quan; Li, Ming-Wei; Wang, Ze-Dong; Zhao, Guang-Hui; Zhu, Xing-Quan

    2015-10-01

    Human sparganosis is a food borne zoonosis caused by the plerocercoid larvae (spargana) of various diphyllobothroid tapeworms of the genus Spirometra. Human infections are acquired by ingesting the raw or undercooked meat of snakes or frogs, drinking untreated water, or using raw flesh in traditional poultices. More than 1600 cases of sparganosis have been documented worldwide, mostly in east and southeast Asia. Sporadic cases have been reported in South America, Europe, and Africa, and several cases have been described in travellers returning from endemic regions. Epidemiological data suggest that the increased effect of sparganosis on human health is because of greater consumption of raw meat of freshwater frogs and snakes. This Review provides information about the Spirometra parasites and their lifecycles, summarises clinical features, diagnosis, and treatment of human sparganosis, and describes geographical distribution and infection characteristics of Spirometra parasites in host animals.

  1. Animal Bites

    Science.gov (United States)

    ... to 15 to 20 of every 100 following dog or human bites. Treatment If your child is bleeding from ... dangerous than those from tame, immunized (against rabies) dogs and cats. The health of the animal also is important, so if ...

  2. Identifying prototypical components in behaviour using clustering algorithms.

    Directory of Open Access Journals (Sweden)

    Elke Braun

    Full Text Available Quantitative analysis of animal behaviour is a requirement to understand the task solving strategies of animals and the underlying control mechanisms. The identification of repeatedly occurring behavioural components is thereby a key element of a structured quantitative description. However, the complexity of most behaviours makes the identification of such behavioural components a challenging problem. We propose an automatic and objective approach for determining and evaluating prototypical behavioural components. Behavioural prototypes are identified using clustering algorithms and finally evaluated with respect to their ability to represent the whole behavioural data set. The prototypes allow for a meaningful segmentation of behavioural sequences. We applied our clustering approach to identify prototypical movements of the head of blowflies during cruising flight. The results confirm the previously established saccadic gaze strategy by the set of prototypes being divided into either predominantly translational or rotational movements, respectively. The prototypes reveal additional details about the saccadic and intersaccadic flight sections that could not be unravelled so far. Successful application of the proposed approach to behavioural data shows its ability to automatically identify prototypical behavioural components within a large and noisy database and to evaluate these with respect to their quality and stability. Hence, this approach might be applied to a broad range of behavioural and neural data obtained from different animals and in different contexts.

  3. The Odour, the Animal and the Plant

    Directory of Open Access Journals (Sweden)

    Deidre Tronson

    2001-01-01

    Full Text Available A review of the literature is presented that gives a background to the human sense of smell, then the importance of learnt and innate olfactory cues in animal behaviour. Some possible roles for natural products chemists interested in the interaction between animals and plants are discussed.

  4. Natural selection can favour 'irrational' behaviour

    OpenAIRE

    McNamara, J. M.; Trimmer, P. C.; Houston, A. I.

    2014-01-01

    Understanding decisions is the fundamental aim of the behavioural sciences. The theory of rational choice is based on axiomatic principles such as transitivity and independence of irrelevant alternatives (IIA). Empirical studies have demonstrated that the behaviour of humans and other animals often seems irrational; there can be a lack of transitivity in choice and seemingly irrelevant alternatives can alter decisions. These violations of transitivity and IIA undermine rational choice theory....

  5. Animal Housing: The Secret Life of Students' Pets Is Not Always a Walk in the Park.

    Science.gov (United States)

    Hoover, Eric

    2003-01-01

    Animals owned by college students are particularly vulnerable to neglect, mistreatment, and abandonment, given the fact that pets are usually prohibited from college dorms and student apartments. Some students, however, persist in keeping pets on campus. (SLD)

  6. Global aspirations, local realities: the role of social science research in controlling neglected tropical diseases.

    Science.gov (United States)

    Bardosh, Kevin

    2014-01-01

    Neglected Tropical Diseases (NTDs) are both drivers and manifestations of poverty and social inequality. Increased advocacy efforts since the mid-2000s have led to ambitious new control and elimination targets set for 2020 by the World Health Organisation. While these global aspirations represent significant policy momentum, there are multifaceted challenges in controlling infectious diseases in resource-poor local contexts that need to be acknowledged, understood and engaged. However a number of recent publications have emphasised the "neglected" status of applied social science research on NTDs. In light of the 2020 targets, this paper explores the social science/NTD literature and unpacks some of the ways in which social inquiry can help support effective and sustainable interventions. Five priority areas are discussed, including on policy processes, health systems capacity, compliance and resistance to interventions, education and behaviour change, and community participation. The paper shows that despite the multifaceted value of having anthropological and sociological perspectives integrated into NTD programmes, contemporary efforts underutilise this potential. This is reflective of the dominance of top-down information flows and technocratic approaches in global health. To counter this tendency, social research needs to be more than an afterthought; integrating social inquiry into the planning, monitoring and evaluating process will help ensure that flexibility and adaptability to local realities are built into interventions. More emphasis on social science perspectives can also help link NTD control to broader social determinants of health, especially important given the major social and economic inequalities that continue to underpin transmission in endemic countries.

  7. The Case for Live Attenuated Vaccines against the Neglected Zoonotic Diseases Brucellosis and Bovine Tuberculosis

    Science.gov (United States)

    Pandey, Aseem; Cabello, Ana; Akoolo, Lavoisier; Rice-Ficht, Allison; Arenas-Gamboa, Angela; McMurray, David; Ficht, Thomas A.; de Figueiredo, Paul

    2016-01-01

    Vaccination of humans and animals with live attenuated organisms has proven to be an effective means of combatting some important infectious diseases. In fact, the 20th century witnessed tremendous improvements in human and animal health worldwide as a consequence of large-scale vaccination programs with live attenuated vaccines (LAVs). Here, we use the neglected zoonotic diseases brucellosis and bovine tuberculosis (BTb) caused by Brucella spp. and Mycobacterium bovis (M. bovis), respectively, as comparative models to outline the merits of LAV platforms with emphasis on molecular strategies that have been pursued to generate LAVs with enhanced vaccine safety and efficacy profiles. Finally, we discuss the prospects of LAV platforms in the fight against brucellosis and BTb and outline new avenues for future research towards developing effective vaccines using LAV platforms. PMID:27537413

  8. Homocysteine and Cognitive Performance in Elders with Self-Neglect

    Science.gov (United States)

    Burnett, J.; Smith, S.M.; Aung, K.; Dyer, C.

    2009-01-01

    Elevated plasma homocysteine has been associated with altered cognitive performance in older adults. Elders referred to Adult Protective Services (APS) for self-neglect have been reported to have elevated plasma homocysteine levels and to suffer from cognitive impairment. This study assesses the association, if any, between plasma homocysteine and cognitive performance among elders with self-neglect. Methods: Sixty-five community-living adults, 65 years of age and older, reported to Adult Protective Services for self-neglect and 55 matched controls (matched for age, ethnicity, gender and socio-economic status) consented and participated in this study. The research team conducted in-home comprehensive geriatric assessments which included the mini-mental state exam (MMSE), the 15-item geriatric depression scale (GDS), the Wolf-Klein Clock Drawing Tests (CDT) and a comprehensive nutritional biochemistry panel, which included plasma homocysteine. Student s t tests and Pearson correlations were conducted to assess for bivariate associations. Results: Elders with self-neglect had significantly higher plasma homocysteine levels (M=12.68umol/L, sd=4.4) compared to the controls (M=10.40umol/L, sd=3.61;t=3.21, df=127, p=.002). There were no statistically significant associations between cognitive performance and plasma homocysteine in the self-neglect group, however there was a significant correlation between plasma homocysteine and the CDT among the controls (r=-.296, p=.022). Conclusion: Mean plasma homocysteine levels were significantly higher in elders with self-neglect, however, they do not appear to be related to cognitive performance, indicating that cognitive impairment in elder self-neglect involve mechanisms other than hyperhomocysteinemia. These findings warrant further investigation

  9. Behaviour of domestic violence in the elderly.

    Directory of Open Access Journals (Sweden)

    Yanelis Emilia Tabio Henry

    2013-07-01

    Full Text Available The elder abuse is a destructive behaviour to an older person, which according to its intensity or frequency can produce damaging of physical, psychological, financial, sexual carelessness, neglect of duty and its dimension. A descriptive investigation was made, with the objective to describe the behaviour of domestic violence in older persons of Community Mental Health Center in Jatibonico Municipality during the period: January first until December 31, 2011. The sample was formed by 32 abused elderly. The predominant groups were: ages between 70 – 79 years. (75.0%, the female sex (59.3%, those with marital links (65.6% dissatisfaction with their lives like a psychological symptom (53,2% psychological abused (50,0% and children as principles aggressors. The adult persons studied were a victim of any kind of domestic abused and as a consequence was presented second psychological manifestations.

  10. Foraging currencies, metabolism and behavioural routines.

    Science.gov (United States)

    Houston, Alasdair I; McNamara, John M

    2014-01-01

    A fundamental issue in foraging theory is whether it is possible to find a simple currency that characterizes foraging behaviour. If such a currency exists, then it is tempting to argue that the selective forces that have shaped the evolution of foraging behaviour have been understood. We review previous work on currencies for the foraging behaviour of an animal that maximizes total energy gained. In many circumstances, it is optimal to maximize a suitably modified form of efficiency. We show how energy gain, predation and damage can be combined in a single currency based on reproductive value. We draw attention to the idea that hard work may have an adverse effect on an animal's condition. We develop a model of optimal foraging over a day when a forager's state consists of its energy reserves and its condition. Optimal foraging behaviour in our model depends on energy reserves, condition and time of day. The pattern of optimal behaviour depends strongly on assumptions about the probability that the forager is killed by a predator. If condition is important, no simple currency characterizes foraging behaviour, but behaviour can be understood in terms of the maximization of reproductive value. It may be optimal to adopt a foraging option that results in a rate of energy expenditure that is less than the rate associated with maximizing efficiency.

  11. Development of and access to products for neglected diseases.

    Directory of Open Access Journals (Sweden)

    Joshua Cohen

    Full Text Available INTRODUCTION: Prior research on neglected disease drug development suggested inadequate funding was responsible for relatively few new approvals. In response, significantly more resources have been allocated towards development of drugs targeting neglected diseases. Our objective was to reassess drug development between 1975 and 1999, evaluate progress in neglected disease drug development since 2000, and explain how increased numbers of approvals are a necessary but insufficient condition to improving access. METHODS: To assess numbers of approvals targeting neglected diseases, we employed two distinct methodologies: First, to revisit numbers published in Trouiller et al. (2002 we used their method to count marketed new chemical entities (NCEs between 1975 and 1999. Second, using the G-Finder report as a benchmark, we identified which diseases are currently considered "neglected" to tally approvals in the 1975-1999 and 2000-2009 periods. Searching PharmaProjects and IMS R&D Focus databases as well as websites from numerous drug regulatory agencies, we identified new drug approvals and indications. Also, we examined the World Health Organization's (WHO Essential Drug List (EDL to see which drugs and indications were on the list. FINDINGS: Upon recount, using Trouiller et al. methodology, we found that between 1975 and 1999 more NCEs (n = 32 targeting tropical diseases and tuberculosis were approved than reported in Trouiller et al. (n = 16. Using the G-Finder method of defining neglected diseases, we found 46 new drug approvals between 1975 and 1999. WHO included 85% of these drugs on the EDL. In the period 2000 to May 2009, despite much greater funding, only 26 new drugs and vaccines for neglected diseases were marketed. Of these, WHO placed 50% on the EDL. CONCLUSIONS: Product approvals for neglected diseases have increased, though progress has been uneven, with malaria appearing to benefit most in the short run from increased funding, while

  12. Neglected Basal Cell Carcinomas in the 21st Century

    Directory of Open Access Journals (Sweden)

    Erika Varga

    2011-01-01

    Full Text Available Although tumors on the surface of the skin are considered to be easily recognizable, neglected advanced skin neoplasms are encountered even in the 21st century. There can be numerous causes of the delay in the diagnosis: fear of the diagnosis and the treatment, becoming accustomed to a slowly growing tumor, old age, a low social milieu, and an inadequate hygienic culture are among the factors leading some people not to seek medical advice. The treatment of such advanced neoplasms is usually challenging. The therapy of neglected cases demands an individual multidisciplinary approach and teamwork. Basal cell carcinoma (BCC, the most common cutaneous tumor, usually develops in the elderly, grows slowly, and has an extremely low metastatic potential; these factors are suggesting that BCCs might well be the “ideal candidates” for neglected tumors. Five neglected advanced cases of BCC were diagnosed in our dermatological institute between 2000 and 2009. The clinical characteristics and treatment modalities of these neoplasms are discussed, together with the possible causes of the neglect.

  13. The impact of neglect on initial adaptation to school.

    Science.gov (United States)

    Manly, Jody Todd; Lynch, Michael; Oshri, Assaf; Herzog, Margaret; Wortel, Sanne N

    2013-08-01

    This study examined the impact of child neglect during the first 4 years of life on adaptation to school during kindergarten and first grade in the context of neighborhood poverty (NP). Processes related to the development of school competencies were examined, including the mediational role of cognitive functioning and ego-resiliency (ER) in shaping children's school outcomes. A total of 170 low-income urban children were followed prospectively for 2 years (ages 4-6). Results indicated that neglected children had significantly lower scores on kindergarten classroom behavior and first-grade academic performance than nonneglected children. Children's cognitive performance at age 4, controlling for maternal intelligence quotient, mediated the relation between severity of neglect and children's behavior in kindergarten as well as their academic performance in first grade. Moreover, severity of neglect was related to children's ER at age 4. However, additional ecological adversity in the form of NP moderated the link between ER and classroom behavior, such that at lower levels of poverty, ER mediated the relation between severity of neglect and school adaptation. Conversely, when NP was extreme, the effects of ER were attenuated and ER ceased to predict behavioral performance in kindergarten. The implications of these findings for prevention and intervention are discussed.

  14. Animated symbols

    DEFF Research Database (Denmark)

    Frølunde, Lisbeth

    2008-01-01

    This paper is based on data about animation film production by 18-year-old students in a Danish upper secondary school. The optic is the on-going potential for learning and development of reflection. The purpose is to clarify what might support young people's reflection on media. I propose...... an analytic working model called Animated Symbols concerning critical reflection in a dialogic learning process. The model shows dialogue as interactions that involve two types of transformation: inner ‘learning processes' and outer signs and symbols. The classroom-based research study is part of a Ph...

  15. [Neglected ipsilateral simultaneous ruptures of patellar and quadriceps tendon].

    Science.gov (United States)

    Karahasanoğlu, İlker; Yoloğlu, Osman; Kerimoğlu, Servet; Turhan, Ahmet Uğur

    2015-01-01

    Neglected patellar and quadriceps tendon rupture is a rare injury, but ipsilateral simultaneous patellar and quadriceps tendon rupture was not described in the literature to our knowledge. In this article, we report a 40-year-old healthy male patient with neglected ipsilateral patellar and quadriceps tendon ruptures treated by peroneus longus tendon autograft. Patient had received some conservative and surgical treatments for patellar fracture before applying to our clinic. After our treatment using peroneus longus autograft and interference nails, patient was immobilized for six weeks in cylindrical cast. Flexion exercises and full weight bearing were started after cast removal. Patient had no complaint at postoperative second year. Patient was a neglected case. Surgical repair and early rehabilitation enabled us to achieve a satisfactory outcome.

  16. Non-invasive brain stimulation in neglect rehabilitation: An update.

    Directory of Open Access Journals (Sweden)

    René Martin Müri

    2013-06-01

    Full Text Available Here, we review the effects of non-invasive brain stimulation (NIBS such as transcranial magnetic stimulation (TMS or transcranial direct current stimulation (tDCS in the rehabilitation of neglect. We found 12 studies including 172 patients (10 TMS studies and 2 tDCS studies fulfilling our search criteria. Activity of daily living (ADL measures such as the Barthel Index or more specifically for neglect, the Catherine Bergego Scale were the outcome measure in 3 studies. Five studies were randomized controlled trials with a follow-up time after intervention of up to 6 weeks. One TMS study fulfilled criteria for Class I and one for Class III evidence.The studies are heterogeneous concerning their methodology, outcome measures, and stimulation parameters making firm comparisons and conclusions difficult. Overall, there are however promising results for theta burst stimulation, suggesting that TMS is a powerful add-on therapy in the rehabilitation of neglect patients.

  17. Non-invasive brain stimulation in neglect rehabilitation: an update.

    Science.gov (United States)

    Müri, René Martin; Cazzoli, Dario; Nef, Tobias; Mosimann, Urs P; Hopfner, Simone; Nyffeler, Thomas

    2013-01-01

    Here, we review the effects of non-invasive brain stimulation such as transcranial magnetic stimulation (TMS) or transcranial direct current stimulation (tDCS) in the rehabilitation of neglect. We found 12 studies including 172 patients (10 TMS studies and 2 tDCS studies) fulfilling our search criteria. Activity of daily living measures such as the Barthel Index or, more specifically for neglect, the Catherine Bergego Scale were the outcome measure in three studies. Five studies were randomized controlled trials with a follow-up time after intervention of up to 6 weeks. One TMS study fulfilled criteria for Class I and one for Class III evidence. The studies are heterogeneous concerning their methodology, outcome measures, and stimulation parameters making firm comparisons and conclusions difficult. Overall, there are however promising results for theta-burst stimulation, suggesting that TMS is a powerful add-on therapy in the rehabilitation of neglect patients.

  18. ETHICAL, SOCIO-PSYCHOLOGICAL AND MEDICAL ASPECTS OF CHILD NEGLECT

    Directory of Open Access Journals (Sweden)

    Smaranda Diaconescu

    2015-11-01

    Full Text Available Child neglect was and continues to be a matter of both professional and public interest, thoroughly debated by child protection researchers and specialists, sociologists, psychologists and social workers, specialists in education and health. Drawing on some examples encountered in current medical practice, we tried to identify the causal factors of child neglect from a medical point of view and the attitude that healthcare professionals should adopt towards such situations. The correct and efficient management of medical neglect cases requires an assessment of the child’s needs, the identification of the parents’ resources and guidance of their efforts so as to properly cater to the child’s needs for the purpose of ensuring the optimum health of the latter.

  19. Altruistic defence behaviours in aphids

    Directory of Open Access Journals (Sweden)

    Brodeur Jacques

    2010-01-01

    Full Text Available Abstract Background Altruistic anti-predatory behaviours pose an evolutionary problem because they are costly to the actor and beneficial to the recipients. Altruistic behaviours can evolve through indirect fitness benefits when directed toward kin. The altruistic nature of anti-predatory behaviours is often difficult to establish because the actor can obtain direct fitness benefits, or the behaviour could result from selfish coercion by others, especially in eusocial animals. Non-eusocial parthenogenetically reproducing aphids form colonies of clone-mates, which are ideal to test the altruistic nature of anti-predatory defence behaviours. Many aphids release cornicle secretions when attacked by natural enemies such as parasitoids. These secretions contain an alarm pheromone that alerts neighbours (clone-mates of danger, thereby providing indirect fitness benefits to the actor. However, contact with cornicle secretions also hampers an attacker and could provide direct fitness to the actor. Results We tested the hypothesis that cornicle secretions are altruistic by assessing direct and indirect fitness consequences of smearing cornicle secretions onto an attacker, and by manipulating the number of clone-mates that could benefit from the behaviour. We observed parasitoids, Aphidius rhopalosiphi, foraging singly in patches of the cereal aphid Sitobion avenae of varied patch size (2, 6, and 12 aphids. Aphids that smeared parasitoids did not benefit from a reduced probability of parasitism, or increase the parasitoids' handling time. Smeared parasitoids, however, spent proportionately more time grooming and less time foraging, which resulted in a decreased host-encounter and oviposition rate within the host patch. In addition, individual smearing rate increased with the number of clone-mates in the colony. Conclusions Cornicle secretions of aphids were altruistic against parasitoids, as they provided no direct fitness benefits to secretion

  20. Animal house

    OpenAIRE

    Turka, Laurence A.

    2008-01-01

    While the JCI was originally conceived as a journal that would integrate various scientific approaches to the examination of human physiology and pathophysiology, we now find many of its pages filled with animal models of human disease. Is this a good thing?

  1. Animated Symbols

    DEFF Research Database (Denmark)

    Frolunde, Lisbeth

    ' processer af fem udvalgte elever er gennemgået i forhold til tre opdelinger: filmskabere, filmskabelse processen og film. Den teoretiske tilgang er pragmatisme, social semiotik og diskursanalyse. Modellen "Animating Symbols" er udviklet og diskuteret som forsøg på at forstå reflektion og design som en slags...

  2. Maternal separation fails to render animals more susceptible to methamphetamine-induced conditioned place preference.

    Science.gov (United States)

    Faure, Jacqueline; Stein, Dan J; Daniels, William

    2009-12-01

    The maternal separation (MS) paradigm is an animal model that has been successfully used to study the long term effects of child abuse and neglect. Experiments showed that animals subjected to trauma and stress early in life display behavioural, endocrinological and growth factor abnormalities at a later stage in life, results that mirrored clinical conditions. It is apparent that adverse events early in life may affect the development and maturation of the brain negatively. The purpose of the present study was to investigate whether the abnormal brain development occurring in separated animals would also enhance the development of a preference for psychostimulant drug usage. Rats were subjected to maternal deprivation and further exposed to methamphetamine-induced conditioned place preference (CPP) which primarily measures drug reward (ventral striatum) learning and memory. Apomorphine-induced locomotor activity was also assessed to investigate the effects of methamphetamine on the dorsal (primarily locomotor activity) striatal dopaminergic system. We found that four consecutive injections of methamphetamine resulted in CPP behaviour 24 h after the 4th injection. A further four injections yielded similar CPP results and this effect lasted for at least 7 days until the third CPP assessment. These animals also had decreased ACTH and corticosterone secretions, but the prolactin levels were increased. Prior exposure to maternal separation did not have any effect on the CPP test. The ACTH and corticosterone secretions were also similarly reduced. However maternal separation decreased the release of prolactin and this reduction was not evident in the separated group that received methamphetamine. There was no significant difference in the apomorphine-induced locomotor activity of normally reared animals whether they received methamphetamine or saline. Interestingly there was a significant difference in locomotor activity between the two groups of animals that were

  3. Neglected Distal Humeral Epiphyseal Injury - Two Case Reports

    Directory of Open Access Journals (Sweden)

    Dr. Pankaj Kumar

    2008-07-01

    Full Text Available Distal humeral epiphyseal separation is an uncommon injury in children, which can be missed or misdiagnosed at initial presentation. Awareness of this injury and appropriate radiological assessment helps in proper management. Neglected cases because of inappropriate diagnosis can result in cubitus varus deformity. Full range of movements of elbow can be achieved if properly diagnosed and managed. We present two cases of neglected distal humeral epiphyseal injury in children that resulted in cubitus varus deformity in one case. Full range of movements was achieved in both cases after proper management.

  4. System Dynamics and Modified Cumulant Neglect Closure Schemes

    DEFF Research Database (Denmark)

    Köylüoglu, H. Ugur; Nielsen, Søren R.K.

    Dealing with multipeaked problems, the goal of the paper is to improve the quality of the approximations for the expectations appearing in the differential equations written for the statistical moments of the state vector, guided by insight in the system dynamics. For systems with polynomial non......-linearities, modifications in the cumulant neglect closure scheme are suggested. The methodology is illustrated using the two wells oscillator. An error analysis is performed to compare the modified and ordinary cumulant neglect closure schemes applied at the second and fourth order levels with the exact results available....

  5. Biotecnologia animal

    Directory of Open Access Journals (Sweden)

    Luiz Lehmann Coutinho

    2010-01-01

    Full Text Available A biotecnologia animal tem fornecido novas ferramentas para os programas de melhoramento e, dessa forma, contribuído para melhorar a eficiência da produção dos produtos de origem animal. No entanto, os avanços têm sido mais lentos do que antecipados, especialmente em razão da dificuldade na identificação dos genes responsáveis pelas características fenotípicas de interesse zootécnico. Três estratégias principais têm sido utilizadas para identificar esses genes - mapeamento de QTL, genes candidatos e sequenciamento de DNA e mRNA - e cada uma tem suas vantagens e limitações. O mapeamento de QTL permite determinar as regiões genômicas que contêm genes, mas o intervalo de confiança do QTL pode ser grande e conter muitos genes. A estratégia de genes candidatos é limitada por causa do conhecimento ainda restrito das funções de todos os genes. Os sequenciamentos de genomas e de sequências expressas podem auxiliar na identificação da posição de genes e de vias metabólicas associadas à característica de interesse. A integração dessas estratégias por meio do desenvolvimento de programas de bioinformática permitirá a identificação de novos genes de interesse zootécnico. Assim, os programas de melhoramento genético se beneficiarão pela inclusão da informação obtida diretamente do DNA na avaliação do mérito genético dos plantéis disponíveis.Animal biotechnology is providing new tools for animal breeding and genetics and thus contributing to advances in production efficiency and quality of animal products. However, the progress is slower than anticipated, mainly because of the difficulty involved in identifying genes that control phenotypic characteristics of importance to the animal industry. Three main strategies: QTL mapping, candidate genes and DNA and mRNA sequencing have been used to identify genes of economic interest to animal breeding and each has advantages and disadvantages. QTL mapping allows

  6. The neglected zoonoses--the case for integrated control and advocacy.

    Science.gov (United States)

    Welburn, S C; Beange, I; Ducrotoy, M J; Okello, A L

    2015-05-01

    The neglected zoonotic diseases (NZDs) have been all but eradicated in wealthier countries, but remain major causes of ill-health and mortality across Africa, Asia, and Latin America. This neglect is, in part, a consequence of under-reporting, resulting in an underestimation of their global burden that downgrades their relevance to policy-makers and funding agencies. Increasing awareness about the causes of NZDs and how they can be prevented could reduce the incidence of many endemic zoonoses. Addressing NZDs by targeting the animal reservoir can deliver a double benefit, as enhanced animal health means a reduced risk of infection for humans, as well as improved livelihoods through increased animal productivity. Advocacy for NZD control is increasing, but with it comes a growing awareness that NZD control demands activities both in the short term and over a long period of time. Moreover, despite the promise of cheap, effective vaccines or other control tools, these endemic diseases will not be sustainably controlled in the near future without long-term financial commitment, particularly as disease incidence decreases and other health priorities take hold. NZD intervention costs can seem high when compared with the public health benefits alone, but these costs are easily outweighed when a full cross-sector analysis is carried out and monetary/non-monetary benefits--particularly regarding the livestock sector--are taken into account. Public-private partnerships have recently provided advocacy for human disease control, and could prove equally effective in addressing endemic zoonoses through harnessing social impact investments. Evidence of the disease burdens imposed on communities by the NZDs and demonstration of the cost-effectiveness of integrated control can strengthen the case for a One Health approach to endemic zoonotic disease control.

  7. Animal Locomotion

    CERN Document Server

    Taylor, Graham K; Tropea, Cameron

    2010-01-01

    This book provides a wide-ranging snapshot of the state-of-the-art in experimental research on the physics of swimming and flying animals. The resulting picture reflects not only upon the questions that are of interest in current pure and applied research, but also upon the experimental techniques that are available to answer them. Doubtless, many new questions will present themselves as the scope and performance of our experimental toolbox develops over the coming years.

  8. Evaluating Multidisciplinary Child Abuse and Neglect Teams: A Research Agenda

    Science.gov (United States)

    Lalayants, Marina; Epstein, Irwin

    2005-01-01

    A review of child welfare research literature reveals that although multidisciplinary teams are increasingly used to investigate and intervene in child abuse and neglect cases, the field does not know enough about their structural variations, implementation processes, or effectiveness. Moreover, although articles advocating multidisciplinary teams…

  9. Unilateral neglect syndrome after stroke: the role of Occupational Therapy

    Directory of Open Access Journals (Sweden)

    Tamara Pereira de Oliveira

    2014-09-01

    Full Text Available Unilateral Neglect Syndrome is one of the consequences of cerebral vascular accident (CVA generally following right parietal lobe lesion, leading to the impairment of perceptive visual, spatial and attention functions. The patient affected does not realize the environmental stimuli on the contralesional hemibody. Occupational therapy plays an important role in caring for this patient, seeking the recovery of perception, attention and social engagement. This study aimed to describe and evaluate the results of occupational therapy intervention and treatment in a single Unilateral Neglect Syndrome post CVA patient. Data were obtained from a survey of the patient’s medical records and interviews of his therapist and caretaker. The analysis of the patient’s medical records and his therapist’s report showed that the patient responded satisfactorily to treatment, presenting a decrease of the left unilateral neglect at the end of the study period. The favorable outcome of the patient outlined the relevance of evaluating the effects of Occupational Therapy interventions for clinical unilateral neglect syndrome.

  10. The Neglected Situation: Assessment Performance and Interaction in Context

    Science.gov (United States)

    Maddox, Bryan

    2015-01-01

    Informed by Goffman's influential essay on "The neglected situation" this paper examines the contextual and interactive dimensions of performance in large-scale educational assessments. The paper applies Goffman's participation framework and associated theory in linguistic anthropology to examine how testing situations are framed and…

  11. Parental Psychopathology and Paternal Child Neglect in Late Childhood

    Science.gov (United States)

    Stewart, Chris; Mezzich, Ada C.; Day, Bang-Shiuh

    2006-01-01

    We aimed at determining the association of both severity of paternal and maternal substance use disorder (SUD) and psychiatric disorders with paternal child neglect severity during late childhood. The sample comprised 146 intact SUD (n=71) and non SUD (n=75) families with a 10-12 year old female or male biological offspring. The average age of…

  12. Severe Neglect and Computer-based Home Training

    DEFF Research Database (Denmark)

    Wilms, Inge Linda

    2014-01-01

    Abstract. Cognitive rehabilitation from a functional perspective often requires intensive training over a longer period of time. In the case of rehabilitation of unilateral neglect, the frequency and intensity needed is expensive and difficult to implement both for the therapists and the patients...

  13. Fat-Soluble Vitamin Status in Self-Neglecting Elderly

    Science.gov (United States)

    Kala, G.; Oliver, S. Mathews; Kelly, P. A.; Pickens, S.; Burnett, J.; Dyer, C. B.; Smith, S. M.

    2006-01-01

    Elder self-neglect is a form of elder mistreatment. The systematic characterization of self-neglecting individuals is the goal of the CREST project. Reported here is the evaluation of fat-soluble vitamin status. Self-neglect (SN) subjects were recruited and consented following referral from Adult Protective Services. Control (CN) subjects were matched for age, gender, race, and socioeconomic status, as possible. We report here on 47 SN subjects (age 77 plus or minus 7, mean plus or minus SD; body weight 76 kg plus or minus 26) and 40 CN subjects (77 y plus or minus 7, 79 kg plus or minus 20). Blood samples were analyzed for indices of fat-soluble vitamin status. Plasma retinol (p less than 0.01) was lower in SN subjects. Plasma tocopherol tended (p less than 0.06) to be lower in SN subjects, while gamma-tocopherol was unchanged. SN subjects tended to have lower serum 25-OH vitamin D (p less than 0.11), and to be vitamin D deficient (26% below 23 mmol/L). Hypercalcemia occurred more often in SN subjects (23% had values above 2.56 mmol/L), as did elevated parathyroid hormone concentrations (p less than 0.05). These data demonstrate that many nutrients are affected in the self-neglecting elderly, and that long-term deficits are evident by the nature of changes in fat soluble vitamins.

  14. Staphylococcal disease in Africa : another neglected 'tropical' disease

    NARCIS (Netherlands)

    Herrmann, Mathias; Abdullah, Salim; Alabi, Abraham; Alonso, Pedro; Friedrich, Alexander W.; Fuhr, Guenther; Germann, Anja; Kern, Winfried V.; Kremsner, Peter G.; Mandomando, Inacio; Mellmann, Alexander C.; Pluschke, Gerd; Rieg, Siegbert; Ruffing, Ulla; Schaumburg, Frieder; Tanner, Marcel; von Briesen, Hagen; von Eiff, Christof; von Mueller, Lutz; Grobusch, Martin P.; Peters, Georg

    2013-01-01

    The term 'neglected tropical diseases' predominantly refers to single-entity, mostly parasitic diseases. However, a considerable morbidity and mortality burden is carried by patients infected with Gram-positive cocci and Gram-negative bacilli that are prevalent all over the world, yet have impact in

  15. Stroke rehabilitation using noninvasive cortical stimulation: hemispatial neglect.

    Science.gov (United States)

    Mylius, Veit; Ayache, Samar S; Zouari, Hela G; Aoun-Sebaïti, Mehdi; Farhat, Wassim H; Lefaucheur, Jean-Pascal

    2012-08-01

    The rehabilitation of neuropsychological sequels of cerebral stroke such as hemispatial neglect by noninvasive cortical stimulation (NICS) attracts increasing attention from the scientific community. The NICS techniques include primarily repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS). They are based on the concept of either reactivating a hypoactive cortical region affected by the stroke (the right hemisphere in case of neglect) or reducing cortical hyperactivity of the corresponding cortical region in the contralateral hemisphere (the left hemisphere). In the studies published to date on the topic of neglect rehabilitation, rTMS was used to inhibit the left parietal cortex and tDCS to either activate the right or inhibit the left parietal cortex. Sham-controlled NICS studies assessed short-term effects, whereas long-term effects were only assessed in noncontrolled rTMS studies. Further controlled studies of large series of patients are necessary to determine the best parameters of stimulation (including the optimal cortical target location) according to each subtype of neglect presentation and to the time course of stroke recovery. To date, even if there are serious therapeutic perspectives based on imaging data and experimental studies, the evidence is not compelling enough to recommend any particular NICS protocol to treat this disabling condition in clinical practice.

  16. Drug discovery and development for neglected diseases: the DNDi model

    Directory of Open Access Journals (Sweden)

    Eric Chatelain

    2011-03-01

    Full Text Available Eric Chatelain, Jean-Robert IosetDrugs for Neglected Diseases Initiative (DNDi, Geneva, SwitzerlandAbstract: New models of drug discovery have been developed to overcome the lack of modern and effective drugs for neglected diseases such as human African trypanosomiasis (HAT; sleeping sickness, leishmaniasis, and Chagas disease, which have no financial viability for the pharmaceutical industry. With the purpose of combining the skills and research capacity in academia, pharmaceutical industry, and contract researchers, public–private partnerships or product development partnerships aim to create focused research consortia that address all aspects of drug discovery and development. These consortia not only emulate the projects within pharmaceutical and biotechnology industries, eg, identification and screening of libraries, medicinal chemistry, pharmacology and pharmacodynamics, formulation development, and manufacturing, but also use and strengthen existing capacity in disease-endemic countries, particularly for the conduct of clinical trials. The Drugs for Neglected Diseases initiative (DNDi has adopted a model closely related to that of a virtual biotechnology company for the identification and optimization of drug leads. The application of this model to the development of drug candidates for the kinetoplastid infections of HAT, Chagas disease, and leishmaniasis has already led to the identification of new candidates issued from DNDi’s own discovery pipeline. This demonstrates that the model DNDi has been implementing is working but its DNDi, neglected diseases sustainability remains to be proven.Keywords: R&D, screening, lead optimization, human African trypanosomiasis, leishmaniasis, Chagas disease, product development partnerships

  17. Prism adaptation improves postural imbalance in neglect patients

    NARCIS (Netherlands)

    Nijboer, Tanja C W; Olthoff, Liselot; Van der Stigchel, Stefan; Visser-Meily, Johanna M a

    2014-01-01

    Several studies have found a negative relation between neglect and postural imbalance. The aim of the current study was to investigate the influence of a single session of prism adaptation on balance [i.e. mediolateral and anteroposterior center of pressure (CoP)] and postural sway (i.e. mean varian

  18. In the best of families: crossing the line into neglect.

    Science.gov (United States)

    Nadworny, S W

    1994-11-01

    Home care professionals are in a good spot to identify abuse of their elderly patients; unfortunately, this is a delicate issue because so many of the caregivers are family members and the abuse arises out of unintentional neglect. What can nurses and social workers do when they identify such a situation?

  19. The Policy Context: Reversing a State of Neglect

    Science.gov (United States)

    Velleman, Richard

    2010-01-01

    This article briefly outlines the neglect of families within previous UK policy documents relating to drugs and alcohol, and discusses the significant progress that has been made in focusing on the family over the past decade. Although substance misuse causes major problems for many family members, this was not even recognized across the Western…

  20. School Psychologists Working with Children Affected by Abuse and Neglect

    Science.gov (United States)

    Dezen, Kristin A.; Gurl, Aaron; Ping, Jenn

    2010-01-01

    School psychologists encounter children regularly who have been affected by abuse and neglect. Maltreatment adversely affects the mental health status and academic achievement of youth, thereby making the topic an area of concern for school psychologists. More recently, child protection laws have been expanded to include mandatory child abuse…

  1. Does Childhood Disability Increase Risk for Child Abuse and Neglect?

    Science.gov (United States)

    Leeb, Rebecca T.; Bitsko, Rebecca H.; Merrick, Melissa T.; Armour, Brian S.

    2012-01-01

    In this article we review the empirical evidence for the presumptions that children with disabilities are at increased risk for child maltreatment, and parents with disabilities are more likely to perpetrate child abuse and neglect. Challenges to the epidemiological examination of the prevalence of child maltreatment and disabilities are…

  2. School Help Professionals' Ideas on Child Abuse and Neglect

    Science.gov (United States)

    Usakli, Hakan

    2012-01-01

    Method: In this study, a qualitative research has been carried out; there were interviews with 50 school counselors working in Sinop; they stated their ideas on child abuse and neglect. Analysis: Data collected via semi constructed interviews have been subjected to descriptive and content analysis.The participant counselors were asked three…

  3. A School Counselor's Guide to Reporting Child Abuse and Neglect

    Science.gov (United States)

    Sikes, April

    2008-01-01

    The process of reporting abuse can be challenging, traumatic, and at times, overwhelming. In order for school counselors to be effective helpers for children, it is essential that they know how to recognize and prevent child abuse and neglect. The purpose of this article is to provide professional school counselors with information they can use to…

  4. Evidence for a disturbance of the body schema in neglect.

    Science.gov (United States)

    Coslett, H B

    1998-08-01

    Subjects with left neglect often fail to use and, in some instances, recognize the left side of the body. We performed a series of investigations to determine if this deficit is, at least in part, attributable to an impairment in the "body schema," an internal three-dimensional, dynamic representation of the spatial and biomechanical properties of one's body. First, subjects were shown a series of pictures of a single hand and asked to determine if the stimulus was a right or left hand. Subjects with neglect but not other subjects with brain lesions identified pictures of left (contra-lesional) hands significantly less reliably than pictures of right hands. On the basis of evidence demonstrating that the identification of pictured hands involves the matching of the stimuli to an on-line mental representation of one's body, these data suggest that neglect may be associated with a disruption of, or failure to attend to, the body schema. Data from subsequent investigations contrasting patients with left neglect and Gerstmann's syndrome argue for a distinction between a body schema and a "body image," or conceptual representation of the body which articulates with language.

  5. Animal welfare: what has changed in the past 50 years?

    Science.gov (United States)

    2014-07-12

    The 3(rd) CABI symposium on animal welfare and behaviour was held on June 11, and featured a range of talks on 'animals as machines'. The symposium marked the 50(th) anniversary of the publication of the book 'Animal Machines' by Ruth Harrison. The book decried the conditions experienced at that time by many animals kept in intensive farming systems, and the speakers at the symposium discussed how far animal welfare had come since its publication. Georgina Mills reports.

  6. Organizational Behaviour in Construction

    DEFF Research Database (Denmark)

    Kreiner, Kristian

    2013-01-01

    Review of: Organizational Behaviour in Construction / Anthony Walker (Wiley-Blackwell,2011 336 pp)......Review of: Organizational Behaviour in Construction / Anthony Walker (Wiley-Blackwell,2011 336 pp)...

  7. A single blinded randomised controlled pilot trial of prism adaptation for improving self-care in stroke patients with neglect.

    Science.gov (United States)

    Turton, Ailie J; O'Leary, Kelly; Gabb, Judith; Woodward, Rebecca; Gilchrist, Iain D

    2010-04-01

    Prism adaptation has been shown to alleviate the symptoms of unilateral spatial neglect following stroke in single case and small group studies. The purposes of this single blinded pilot randomised controlled trial were to determine the feasibility of delivering prism adaptation treatment in a clinically valid sample and to assess its impact on self-care. Thirty seven right hemisphere stroke patients with unilateral spatial neglect were randomised into either prism adaptation (using 10 dioptre, 6 degree prisms) or sham treatment (using plain glasses) groups. Treatment was delivered each weekday for two weeks. Pointing accuracy, without vision of the finger, was recorded each day before treatment. Outcome was measured, by blinded assessors, four days and eight weeks after the end of treatment using the Catherine Bergego Scale (CBS) and the conventional neuropsychological tests from the Behavioural Inattention Test (BIT). Thirty four patients received treatment: 16 with prisms, 18 sham. Mean compliance was 99% and 97%, respectively. Over the treatment days only the prism treated group showed increased leftward bias in open loop pointing to targets on a touch screen. However, despite the group level changes in pointing behaviour no overall effect of the treatment on self-care or BIT were found.

  8. [Immunization for children travelling to the tropics: neglected vaccines].

    Science.gov (United States)

    Imbert, P; Guérin, N; Sorge, F

    2008-06-01

    Each year hundreds of thousands of children leave France to travel to developing countries where they are exposed to infectious agents that can be prevented by vaccination. During the child's pre-travel check-up, practitioners should check that all mandatory immunizations are up-to-date and provide advice on relevant vaccines in function of the epidemiological situation at the chosen destination. However various factors hinder full compliance with this approach and some vaccines are underused. Underused vaccines are referred to as neglected vaccines. In the French vaccination schedule three vaccinations can be considered as neglected. The first is the hepatitis B vaccine that has a low coverage level in France due to strong reluctance to its use despite the fact that the virus is widespread in tropical areas. The second is pneumococcal vaccine that should be administered to all infants less than 2 years of age, especially for travel to areas where pneumonia and meningitis are frequent. The third is BCG vaccine that is now at greater risk of being neglected in child travellers because its use has been downgraded from a general requirement to a recommendation only for children at risk. A serious limitation on the use of travel vaccinations is cost that can lead families to neglect some infectious risk such as hepatitis A that is a major risk for child travellers as well as for their relatives during or after the trip and typhoid fever that is essentially an imported disease. Rabies vaccine is also underused due to its cost and to poor understanding of the risk by many practitioners and families. The purpose of this article is to underline the need to improve information and access to vaccines that are all too often neglected in child travellers.

  9. Neglected infections of poverty in the United States of America.

    Directory of Open Access Journals (Sweden)

    Peter J Hotez

    Full Text Available In the United States, there is a largely hidden burden of diseases caused by a group of chronic and debilitating parasitic, bacterial, and congenital infections known as the neglected infections of poverty. Like their neglected tropical disease counterparts in developing countries, the neglected infections of poverty in the US disproportionately affect impoverished and under-represented minority populations. The major neglected infections include the helminth infections, toxocariasis, strongyloidiasis, ascariasis, and cysticercosis; the intestinal protozoan infection trichomoniasis; some zoonotic bacterial infections, including leptospirosis; the vector-borne infections Chagas disease, leishmaniasis, trench fever, and dengue fever; and the congenital infections cytomegalovirus (CMV, toxoplasmosis, and syphilis. These diseases occur predominantly in people of color living in the Mississippi Delta and elsewhere in the American South, in disadvantaged urban areas, and in the US-Mexico borderlands, as well as in certain immigrant populations and disadvantaged white populations living in Appalachia. Preliminary disease burden estimates of the neglected infections of poverty indicate that tens of thousands, or in some cases, hundreds of thousands of poor Americans harbor these chronic infections, which represent some of the greatest health disparities in the United States. Specific policy recommendations include active surveillance (including newborn screening to ascertain accurate population-based estimates of disease burden; epidemiological studies to determine the extent of autochthonous transmission of Chagas disease and other infections; mass or targeted treatments; vector control; and research and development for new control tools including improved diagnostics and accelerated development of a vaccine to prevent congenital CMV infection and congenital toxoplasmosis.

  10. Improving left spatial neglect through music scale playing.

    Science.gov (United States)

    Bernardi, Nicolò Francesco; Cioffi, Maria Cristina; Ronchi, Roberta; Maravita, Angelo; Bricolo, Emanuela; Zigiotto, Luca; Perucca, Laura; Vallar, Giuseppe

    2017-03-01

    The study assessed whether the auditory reference provided by a music scale could improve spatial exploration of a standard musical instrument keyboard in right-brain-damaged patients with left spatial neglect. As performing music scales involves the production of predictable successive pitches, the expectation of the subsequent note may facilitate patients to explore a larger extension of space in the left affected side, during the production of music scales from right to left. Eleven right-brain-damaged stroke patients with left spatial neglect, 12 patients without neglect, and 12 age-matched healthy participants played descending scales on a music keyboard. In a counterbalanced design, the participants' exploratory performance was assessed while producing scales in three feedback conditions: With congruent sound, no-sound, or random sound feedback provided by the keyboard. The number of keys played and the timing of key press were recorded. Spatial exploration by patients with left neglect was superior with congruent sound feedback, compared to both Silence and Random sound conditions. Both the congruent and incongruent sound conditions were associated with a greater deceleration in all groups. The frame provided by the music scale improves exploration of the left side of space, contralateral to the right hemisphere, damaged in patients with left neglect. Performing a scale with congruent sounds may trigger at some extent preserved auditory and spatial multisensory representations of successive sounds, thus influencing the time course of space scanning, and ultimately resulting in a more extensive spatial exploration. These findings offer new perspectives also for the rehabilitation of the disorder.

  11. The role of genes, epigenetics and ontogeny in behavioural development

    NARCIS (Netherlands)

    Rodenburg, T.B.

    2014-01-01

    This review focuses on the role of genes, epigenetics and ontogeny in behavioural devel-opment of animals. The behavioural characteristics of an individual are determined by itsgenes and by its physical and social environment. Not only the individual’s early life andcurrent environment are of import

  12. Organizational Behaviour Study Material

    OpenAIRE

    P. Sreeramana Aithal

    2016-01-01

    An overview of Organizational Behaviour – History of Organisational Behaviour and its  emergence as a disciple-emerging perspective Organizational Behaviour.  Individual process in organisation – Learning, perception and attribution- Individual differences - Basic concepts of motivation - Advanced concepts of motivation. Group process in Organisation – Group dynamics, leadership theories - Power, politics and conflict - inter- personal communication. Enhancing individu...

  13. Interacting personalities: behavioural ecology meets quantitative genetics.

    Science.gov (United States)

    Dingemanse, Niels J; Araya-Ajoy, Yimen G

    2015-02-01

    Behavioural ecologists increasingly study behavioural variation within and among individuals in conjunction, thereby integrating research on phenotypic plasticity and animal personality within a single adaptive framework. Interactions between individuals (cf. social environments) constitute a major causative factor of behavioural variation at both of these hierarchical levels. Social interactions give rise to complex 'interactive phenotypes' and group-level emergent properties. This type of phenotype has intriguing evolutionary implications, warranting a cohesive framework for its study. We detail here how a reaction-norm framework might be applied to usefully integrate social environment theory developed in behavioural ecology and quantitative genetics. The proposed emergent framework facilitates firm integration of social environments in adaptive research on phenotypic characters that vary within and among individuals.

  14. Animal Testing

    Science.gov (United States)

    Moretto, Johnny; Chauffert, Bruno; Bouyer, Florence

    The development of a new anticancer drug is a long, complex and multistep process which is supervised by regulatory authorities from the different countries all around the world [1]. Application of a new drug for admission to the market is supported by preclinical and clinical data, both including the determination of pharmacodynamics, toxicity, antitumour activity, therapeutic index, etc. As preclinical studies are associated with high cost, optimization of animal experiments is crucial for the overall development of a new anticancer agent. Moreover, in vivo efficacy studies remain a determinant panel for advancement of agents to human trials and thus, require cautious design and interpretation from experimental and ethical point of views.

  15. Animation & Neurocinematics*

    DEFF Research Database (Denmark)

    Carpe Pérez, Inmaculada Concepción

    2016-01-01

    We love movies because we like to jump from our “reality” to live a dream, a parallel universe that inspires us. We long for adventure, excitement and answers to quests… That’s the magic of cinema; it makes you believe what you see and over all, FEEL it. As Antonio Damasio said-“ we´re feeling...... machines that think”-(Damasio, A. Descartes error). Such feelings come from the interpretation of the emotions in our bodies. Emotions are our universal language, the motivation of living, the key to what makes a movie successful and truly an art piece that you will remember because moves you. Animation...

  16. Evolution of central pattern generators and rhythmic behaviours.

    Science.gov (United States)

    Katz, Paul S

    2016-01-01

    Comparisons of rhythmic movements and the central pattern generators (CPGs) that control them uncover principles about the evolution of behaviour and neural circuits. Over the course of evolutionary history, gradual evolution of behaviours and their neural circuitry within any lineage of animals has been a predominant occurrence. Small changes in gene regulation can lead to divergence of circuit organization and corresponding changes in behaviour. However, some behavioural divergence has resulted from large-scale rewiring of the neural network. Divergence of CPG circuits has also occurred without a corresponding change in behaviour. When analogous rhythmic behaviours have evolved independently, it has generally been with different neural mechanisms. Repeated evolution of particular rhythmic behaviours has occurred within some lineages due to parallel evolution or latent CPGs. Particular motor pattern generating mechanisms have also evolved independently in separate lineages. The evolution of CPGs and rhythmic behaviours shows that although most behaviours and neural circuits are highly conserved, the nature of the behaviour does not dictate the neural mechanism and that the presence of homologous neural components does not determine the behaviour. This suggests that although behaviour is generated by neural circuits, natural selection can act separately on these two levels of biological organization.

  17. Behavioural Study of Captive Sloth Bears Using Environmental Enrichment Tools

    Directory of Open Access Journals (Sweden)

    M. Veeraselvam

    2013-01-01

    Full Text Available Effects of environmental enrichment on behavioural changes were studied in five captive sloth bears kept in confined enclosure at Zoological Park, Chennai, India. Behavioural categories like active, passive, and abnormal behaviours were taken for the study. The activity budget was recorded as a single animal scan. The detailed baseline data of 150 hours, over a period of 30 days, were collected. At baseline, bears exhibited passive and more abnormal behaviours. Similarly, after application of the environmental tools like honey-log, underground food pipes, and wobbling box in the enclosure, the data were collected for 150 hours (30 days. Increased active behaviours and decreased abnormal behaviours were observed and showed highly significant changes in the abnormal behaviour as a whole when compared to the baseline level. During the postenrichment period, the data that were collected for 150 hours (30 days showed no significant differences statistically between the behavioural categories. But certain level of difference was evident from the percentage of abnormal behaviours exhibited by individual bears. Among the enrichment devices, honey-log was the most preferred enrichment tool as revealed by the percentage of time spent by individual animal. The results show that application of enrichment tool continuously may bring long term effect in stereotypic behaviour.

  18. Neural bases of personal and extrapersonal neglect in humans.

    Science.gov (United States)

    Committeri, Giorgia; Pitzalis, Sabrina; Galati, Gaspare; Patria, Fabiana; Pelle, Gina; Sabatini, Umberto; Castriota-Scanderbeg, Alessandro; Piccardi, Laura; Guariglia, Cecilia; Pizzamiglio, Luigi

    2007-02-01

    Human awareness of left space may be disrupted by cerebral lesions to the right hemisphere (hemispatial neglect). Current knowledge on the anatomical bases of this complex syndrome is based on the results of group studies that investigated primarily the best known aspect of the syndrome, which is visual neglect for near extrapersonal (or peripersonal) space. However, another component-neglect for personal space-is more often associated with, than double-dissociated from, extrapersonal neglect, especially, in chronic patients. The present investigation aimed at exploring the anatomical substrate of both extrapersonal and personal neglect by using different advanced methodological approaches to lesion-function correlation. Fifty-two right ischaemic patients were submitted to neuropsychological assessment and in-depth MRI evaluation. The borders of each patient's lesion were delimited onto its own high-resolution anatomical image and then submitted to an automated spatial normalization algorithm. Besides conventional lesion density plots and subtraction analysis, region-based statistical analyses were performed on percentage values of the lesioned tissue also using a new parcellation of the white matter (WM). Data were finally submitted to voxelwise statistical analysis using a recently proposed method (voxel-based lesion-symptom mapping). Results converged in showing that awareness of extrapersonal space is based on the integrity of a circuit of right frontal (ventral premotor cortex and middle frontal gyrus) and superior temporal regions, whereas awareness of personal space is rooted in right inferior parietal regions (supramarginal gyrus, post-central gyrus and especially the WM medial to them). Common but less crucial regions for both neglect sub-types were located in the temporo-peri-Sylvian cortex. We suggest that extrapersonal space awareness critically involves a ventral circuit recently described for the exogenous allocation and reorienting of attention in

  19. Neglecting the left side of a city square but not the left side of its clock: prevalence and characteristics of representational neglect.

    Science.gov (United States)

    Guariglia, Cecilia; Palermo, Liana; Piccardi, Laura; Iaria, Giuseppe; Incoccia, Chiara

    2013-01-01

    Representational neglect, which is characterized by the failure to report left-sided details of a mental image from memory, can occur after a right hemisphere lesion. In this study, we set out to verify the hypothesis that two distinct forms of representational neglect exist, one involving object representation and the other environmental representation. As representational neglect is considered rare, we also evaluated the prevalence and frequency of its association with perceptual neglect. We submitted a group of 96 unselected, consecutive, chronic, right brain-damaged patients to an extensive neuropsychological evaluation that included two representational neglect tests: the Familiar Square Description Test and the O'Clock Test. Representational neglect, as well as perceptual neglect, was present in about one-third of the sample. Most patients neglected the left side of imagined familiar squares but not the left side of imagined clocks. The present data show that representational neglect is not a rare disorder and also support the hypothesis that two different types of mental representations (i.e. topological and non-topological images) may be selectively damaged in representational neglect.

  20. Neglecting the left side of a city square but not the left side of its clock: prevalence and characteristics of representational neglect.

    Directory of Open Access Journals (Sweden)

    Cecilia Guariglia

    Full Text Available Representational neglect, which is characterized by the failure to report left-sided details of a mental image from memory, can occur after a right hemisphere lesion. In this study, we set out to verify the hypothesis that two distinct forms of representational neglect exist, one involving object representation and the other environmental representation. As representational neglect is considered rare, we also evaluated the prevalence and frequency of its association with perceptual neglect. We submitted a group of 96 unselected, consecutive, chronic, right brain-damaged patients to an extensive neuropsychological evaluation that included two representational neglect tests: the Familiar Square Description Test and the O'Clock Test. Representational neglect, as well as perceptual neglect, was present in about one-third of the sample. Most patients neglected the left side of imagined familiar squares but not the left side of imagined clocks. The present data show that representational neglect is not a rare disorder and also support the hypothesis that two different types of mental representations (i.e. topological and non-topological images may be selectively damaged in representational neglect.

  1. Staphylococcal disease in Africa: another neglected 'tropical' disease.

    Science.gov (United States)

    Herrmann, Mathias; Abdullah, Salim; Alabi, Abraham; Alonso, Pedro; Friedrich, Alexander W; Fuhr, Günther; Germann, Anja; Kern, Winfried V; Kremsner, Peter G; Mandomando, Inacio; Mellmann, Alexander C; Pluschke, Gerd; Rieg, Siegbert; Ruffing, Ulla; Schaumburg, Frieder; Tanner, Marcel; Peters, Georg; von Briesen, Hagen; von Eiff, Christof; von Müller, Lutz; Grobusch, Martin P

    2013-01-01

    The term 'neglected tropical diseases' predominantly refers to single-entity, mostly parasitic diseases. However, a considerable morbidity and mortality burden is carried by patients infected with Gram-positive cocci and Gram-negative bacilli that are prevalent all over the world, yet have impact in tropical and developing countries, particularly in children, with much higher incidence rates than those reported from developed countries. Staphylococcus aureus is among these pathogens. The African-German StaphNet consortium uses microbiological characterization of African S. aureus isolates, including identification of virulence factors, alongside the gathering of epidemiological and clinical data in an innovative research network between a European country (Germany) and several African partners. By creating an accessible strain repository and by implementing personnel training and capacity building, this network aims to put staphylococcal disease on the international agenda as a truly neglected condition with a major global impact on public health.

  2. Can soil respiration estimate neglect the contribution of abiotic exchange?

    Institute of Scientific and Technical Information of China (English)

    Xi CHEN; WenFeng WANG; GePing LUO; Hui YE

    2014-01-01

    This study examines the hypothesis that soil respiration can always be interpreted purely in terms of biotic processes, neglecting the contribution of abiotic exchange to CO2 fluxes in alkaline soils of arid areas that characterize 5%of the Earth’s total land surface. Analyses on flux data collected from previous studies suggested reconciling soil respiration as organic (root/microbial respiration) and inorganic (abiotic CO2 exchange) respiration, whose contributions in the total CO2 flux were determined by soil alkaline content. On the basis of utilizing mete-orological and soil data collected from the Xinjiang and Central Asia Scientific Data Sharing Platform, an incorpo-rated model indicated that inorganic respiration represents almost half of the total CO2 flux. Neglecting the abiotic module may result in overestimates of soil respiration in arid alkaline lands, which partly explains the long-sought“missing carbon sink”.

  3. Lexical Processes and Eye Movements in Neglect Dyslexia

    Directory of Open Access Journals (Sweden)

    Giuseppe di Pellegrino

    2002-01-01

    Full Text Available Neglect dyslexia is a disturbance in the allocation of spatial attention over a letter string following unilateral brain damage. Patients with this condition may fail to read letters on the contralesional side of an orthographic string. In some of these cases, reading is better with words than with non-words. This word superiority effect has received a variety of explanations that differ, among other things, with regard to the spatial distribution of attention across the letter string during reading. The primary goal of the present study was to explore the interaction between attention and lexical processes by recording eye movements in a patient (F.C. with severe left neglect dyslexia who was required to read isolated word and non-word stimuli of various length.

  4. Neglected lesser tuberosity avulsion in an adolescent elite gymnast.

    Science.gov (United States)

    Paxinos, Odysseas; Karavasili, Alexandra; Manolarakis, Manolis; Paxinos, Thrasivoulos; Papavasiliou, Athanasios

    2014-07-01

    We report the case of a 16-year-old elite gymnast who presented with recurring pain in the left shoulder after training. The athlete recalled an injury to the shoulder 2 years ago. Clinically a localized tenderness to the anterior shoulder and loss of strength and range of motion was noted. Imaging investigation suggested a neglected lesser tuberosity avulsion. The athlete was treated with open excision of the deformed tuberosity and direct repair of the subscapularis to the humeral head. Following a careful postoperative rehabilitation protocol the athlete was able to return to unrestricted gymnastics after 6 months. After surgery the athlete followed a intense rehabilitation program that allowed him to return to sports at 6 months. At 5-years follow-up, the athlete was asymptomatic and competing at an international level. Avulsion fractures of the lesser tuberosity are extremely rare injuries with significant shoulder disability if left untreated. Anatomic repair can yield excellent results, even in neglected cases.

  5. Inattention, Working Memory, and Goal Neglect in a Community Sample

    Science.gov (United States)

    Elisa, Rebecca N.; Balaguer-Ballester, Emili; Parris, Benjamin A.

    2016-01-01

    Executive function deficits have been linked to attention deficit hyperactivity disorder (ADHD), but it has been theorized that the symptom inattention is specifically related to problems with complex verbal working memory (WM). Using the Conners Adult ADHD rating scale, adults aged 18–35 were assessed for ADHD symptoms, and completed tasks designed to tap verbal and spatial aspects of WM (Experiment 1). Results showed that high inattention predicted poor performance on both simple and complex verbal WM measures. Results relating to spatial WM were inconclusive. In a follow up experiment based on the theory that those with inattention have problems receiving verbal instructions, a measure of goal neglect assessing integration of information into a task model in WM was employed (Experiment 2). Results showed that high inattention uniquely predicted performance on this task, representing the first reported association between inattention and the phenomenon of goal neglect. The results from both experiments lend support to the WM theory of inattention. PMID:27713716

  6. Hookworm infection: A neglected tropical disease of mankind

    OpenAIRE

    Muhammed Hossain; Jamal Uddin Bhuiyan

    2016-01-01

    Hookworm infection, a global problem of human, is caused by both Ancylostoma duodenale and Necator americanus. These parasites are considered as important blood feeding nematodes. Hookworm is usually prevalent among the people who live with low socio-economic status. However, this tropical disease is neglected in most cases. This review was aimed at investigating the insights of hookworm infection of human considering its epidemiology, pathogenesis, clinical manifestation, diagnosis, treatmen...

  7. Metaphorical Competence: A Neglected Component of Communicative Competence

    OpenAIRE

    Masoud Khalili Sabet; Marjaneh Tavakoli

    2016-01-01

    The ability to comprehend and use metaphors in L2 which is referred to as metaphorical competence is an important issue in second language acquisition. Metaphors are so pervasive in our life that we might not realize their presence and simply neglect them even in our first language. Different models of communicative competence have been suggested in the literature; however, the model of Bachman and Palmer (1996) is the one considered in the present study. It includes two major nodes of organi...

  8. [To overcome neglected tropical diseases by global health governance].

    Science.gov (United States)

    Yao, Jia-Wen; Zhou, Xiao-Nong

    2013-04-01

    Neglected tropical diseases (NTDs) are common infections of the poorest people of the world. The WHO publication of a roadmap that lays out the vision for ending the misery caused by NTDs has inspired the London Declaration on NTDs, which demonstrates that the global public-health agenda now embraces NTDs. This review discusses the advantages of global health governance in overcoming NTDs, and points out the potential ways of the involvement of China in global health through international collaboration.

  9. Effect of eye patching in rehabilitation of neglect

    Directory of Open Access Journals (Sweden)

    Nicola eSmania

    2013-09-01

    Full Text Available Eye patching (monocular or right hemifield has been proposed to improve visuospatial attention to the ignored field in patients with neglect. The aim of this paper is to review the literature on the effects of eye patching in hemispatial neglect after stroke in order to convey evidence-based recommendations to clinicians in stroke rehabilitation. Thirteen intervention studies were selected from the Medline, EMBASE, Scopus, Cochrane Library, CINAHL, PsychINFO, EBRSR and Health Star databases. Methodological quality was defined according to the Physiotherapy Evidence Database. Overall, seven studies used monocular eye patching, five used right hemifield patching and one compared right monocular with right hemifield patching. Seven studies compared normal viewing to monocular or hemifield patching conditions. Six studies included a period of treatment. Three studies included follow-up evaluations. As to the monocular eye patching, four studies reported positive effects of right monocular patching. One study showed an improvement in hemispatial neglect with left monocular patching. Two studies found no superiority of right versus left monocular patching. One study found no effects of right monocular patching. As to the right hemifield eye patching, one study showed improvements in neglect after right hemifield patching. Three studies found that right hemifield patching combined with another rehabilitation technique was more effective than that treatment alone. One study found no differences between right hemifield patching combined with another treatment and that treatment alone. One study found the same effect between right hemifield patching alone and another rehabilitation technique.Our results globally tend to support the usefulness of right hemifield eye patching in clinical practice. In order to define a level of evidence with the standard rehabilitation evidence rating tools, further properly powered randomized controlled trials or meta

  10. The behavioural ecology of climbing plants.

    Science.gov (United States)

    Gianoli, Ernesto

    2015-02-12

    Climbing plants require an external support to grow vertically and enhance light acquisition. Vines that find a suitable support have greater performance and fitness than those that remain prostrate. Therefore, the location of a suitable support is a key process in the life history of climbing plants. Numerous studies on climbing plant behaviour have elucidated mechanistic details of support searching and attachment. Far fewer studies have addressed the ecological significance of support-finding behaviour and the factors that affect it. Without this knowledge, little progress can be made in the understanding of the evolution of support-finding behaviour in climbers. Here I review studies addressing ecological causes and consequences of support finding and use by climbing plants. I also propose the use of behavioural ecology theoretical frameworks to study climbing plant behaviour. I show how host tree attributes may determine the probability of successful colonization for the different types of climbers, and examine the evidence of environmental and genetic control of circumnutation behaviour and phenotypic responses to support availability. Cases of oriented vine growth towards supports are highlighted. I discuss functional responses of vines to the interplay between herbivory and support availability under different abiotic environments, illustrating with one study case how results comply with a theoretical framework of behavioural ecology originally conceived for animals. I conclude stressing that climbing plants are suitable study subjects for the application of behavioural-ecological theory. Further research under this framework should aim at characterizing the different stages of the support-finding process in terms of their fit with the different climbing modes and environmental settings. In particular, cost-benefit analysis of climbing plant behaviour should be helpful to infer the selective pressures that have operated to shape current climber ecological

  11. Right-Hemisphere (Spatial? Acalculia and the Influence of Neglect

    Directory of Open Access Journals (Sweden)

    Silvia eBenavides-Varela

    2014-08-01

    Full Text Available The present study aimed at exploring basic number and calculation abilities in right-hemisphere damaged patients (RHD, focusing primarily on one-digit orally presented tasks, which do not require explicit visuo-spatial abilities. Twenty-four non mentally-deteriorated RHD patients (12 with clinical neglect (RHDN+, 12 without clinical neglect (RHDN-, and 12 healthy controls were included in the study. Participants were administered an ad hoc numerical battery assessing abilities such as counting, number magnitude comparison, writing and reading Arabic numerals and mental calculation, among others. Significant differences emerged among healthy controls and both the RHDN+ group and the RHDN- group, suggesting that the mathematical impairment of RHD patients does not necessarily correspond to the presence of left-neglect. A detailed analysis of the sub-tests of the battery evidenced expected differences among RHDN+ patients, RHDN- patients, and controls in writing and reading Arabic numerals. Crucially, differences between RHDN+ patients and controls were also found in tasks such as mental subtraction and mental multiplication. The present findings thus suggest that unilateral right hemisphere lesions may produce specific representational deficits that affect simple mental calculation, and not only the spatial arrangement of multi-digit written numbers as previously thought.

  12. Right-hemisphere (spatial?) acalculia and the influence of neglect.

    Science.gov (United States)

    Benavides-Varela, Silvia; Pitteri, Marco; Priftis, Konstantinos; Passarini, Laura; Meneghello, Francesca; Semenza, Carlo

    2014-01-01

    The present study aimed at exploring basic number and calculation abilities in right-hemisphere damaged patients (RHD), focusing primarily on one-digit orally presented tasks, which do not require explicit visuo-spatial abilities. Twenty-four non mentally-deteriorated RHD patients [12 with clinical neglect (RHDN+), 12 without clinical neglect (RHDN-)], and 12 healthy controls were included in the study. Participants were administered an ad hoc numerical battery assessing abilities such as counting, number magnitude comparison, writing and reading Arabic numerals and mental calculation, among others. Significant differences emerged among healthy controls and both the RHDN+ group and the RHDN- group, suggesting that the mathematical impairment of RHD patients does not necessarily correspond to the presence of left-neglect. A detailed analysis of the sub-tests of the battery evidenced expected differences among RHDN+ patients, RHDN- patients, and controls in writing and reading Arabic numerals. Crucially, differences between RHDN+ patients and controls were also found in tasks such as mental subtraction and mental multiplication, which do not require written visuo-spatial abilities. The present findings thus suggest that unilateral right hemisphere lesions may produce specific representational deficits that affect simple mental calculation, and not only the spatial arrangement of multi-digit written numbers as previously thought.

  13. Neglect and extinction depend greatly on task demands: A review

    Directory of Open Access Journals (Sweden)

    Mario eBonato

    2012-07-01

    Full Text Available This review illustrates how, after unilateral brain damage, the presence and severity of spatial awareness deficits for the contralesional hemispace depend greatly on the quantity of attentional resources available for performance. After a brief description of neglect and extinction, different frameworks accounting for spatial and non-spatial attentional processes will be outlined. The central part of the review will describe how the performance of brain damaged patients is negatively affected by increased task demands, which can result in the emergence of severe awareness deficits for contralesional space even in patients who perform normally on paper-and-pencil tests. Throughout the review neglect is described as a spatial syndrome that can be exacerbated in the presence and severity by both spatial and non-spatial tasks. The take-home message is that the presence and degree of contralesional neglect and extinction can be dramatically overlooked based on standard paper-and-pencil testing, where patients can easily compensate for their deficits. Only tasks where compensation is made impossible represent an appropriate approach to detect these disabling contralesional deficits of awareness that become subtle in post-acute stroke phases.

  14. Neglect of the elderly: forensic entomology cases and considerations.

    Science.gov (United States)

    Benecke, Mark; Josephi, Eberhard; Zweihoff, Ralf

    2004-12-01

    Wounds of living persons are a potential target for the same flies that live, or feed early on corpses. This can lead to complications in estimation of PMI but also allows to determine additional information that might be valuable in a trial, or during the investigations [e.g., M. Benecke, R. Lessig, Child neglect and forensic entomology, Forensic Sci. Int. 120 (2001) 155-159]. With forensic entomology, and forensic entomologists being more and more present, even lower profile cases like the neglect of elderly people (without violence being used against them; i.e., natural death) comes to our attention. Furthermore, much more people grow older than in the past years which leads to increased awareness of malpractice of caregivers in the professional, and personal environment [DPA (German Press Agency), Studie an 17000 Leichen: Jeder Siebte vor Tod falsch gepflegt (Every seventh elderly person not cared for sufficiently), German Press Agency dpa # 051402, Jan 3, Jan 5, 2003] . We briefly sketch three cases in which forensic entomology helped to better understand the circumstances of death, and the type and intensity of neglect before death.

  15. Drug discovery and development for neglected diseases: the DNDi model.

    Science.gov (United States)

    Chatelain, Eric; Ioset, Jean-Robert

    2011-03-16

    New models of drug discovery have been developed to overcome the lack of modern and effective drugs for neglected diseases such as human African trypanosomiasis (HAT; sleeping sickness), leishmaniasis, and Chagas disease, which have no financial viability for the pharmaceutical industry. With the purpose of combining the skills and research capacity in academia, pharmaceutical industry, and contract researchers, public-private partnerships or product development partnerships aim to create focused research consortia that address all aspects of drug discovery and development. These consortia not only emulate the projects within pharmaceutical and biotechnology industries, eg, identification and screening of libraries, medicinal chemistry, pharmacology and pharmacodynamics, formulation development, and manufacturing, but also use and strengthen existing capacity in disease-endemic countries, particularly for the conduct of clinical trials. The Drugs for Neglected Diseases initiative (DNDi) has adopted a model closely related to that of a virtual biotechnology company for the identification and optimization of drug leads. The application of this model to the development of drug candidates for the kinetoplastid infections of HAT, Chagas disease, and leishmaniasis has already led to the identification of new candidates issued from DNDi's own discovery pipeline. This demonstrates that the model DNDi has been implementing is working but its DNDi, neglected diseases sustainability remains to be proven.

  16. Visual neglect following stroke: current concepts and future focus.

    Science.gov (United States)

    Ting, Darren S J; Pollock, Alex; Dutton, Gordon N; Doubal, Fergus N; Ting, Daniel S W; Thompson, Michelle; Dhillon, Baljean

    2011-01-01

    Visual neglect is a common, yet frequently overlooked, neurological disorder following stroke characterized by a deficit in attention and appreciation of stimuli on the contralesional side of the body. It has a profound functional impact on affected individuals. A assessment and management of this condition are hindered, however, by the lack of professional awareness and clinical guidelines. Recent evidence suggests that the underlying deficit in visual attention is due to a disrupted internalized representation of the outer world rather than a disorder of sensory inputs. Dysfunction of the cortical domains and white-matter tracts, as well as inter-hemispheric imbalance, have been implicated in the various manifestations of visual neglect. Optimal diagnosis requires careful history-taking from the patient, family, and friends, in addition to clinical assessment with the line bisection test, the star cancellation test, and the Catherine Bergego Scale. Early recognition and prompt rehabilitation employing a multidisciplinary approach is desirable. Although no treatment has been definitively shown to be of benefit, those with promise include prism adaptation, visual scanning therapy, and virtual reality-based techniques. Further high quality research to seek optimum short- and long-term rehabilitative strategies for visual neglect is required.

  17. Bioethical Problems: Animal Welfare, Animal Rights.

    Science.gov (United States)

    March, B. E.

    1984-01-01

    Discusses various bioethical issues and problems related to animal welfare and animal rights. Areas examined include: Aristotelian views; animal welfare legislation; Darwin and evolutionary theory; animal and human behavior; and vegetarianism. A 14-point universal declaration of the rights of animals is included. (JN)

  18. Factors influencing interactions in zoos: animal-keeper relationship, animal-public interactions and solitary animals groups

    Directory of Open Access Journals (Sweden)

    Giovanni Quintavalle Pastorino

    2015-07-01

    Full Text Available Interactions that animals experience can have a significant influence on their health and welfare. These interactions can occur between animals themselves, but also between animals and keepers, and animals and the public. Human and non-human animals come into contact with each other in a variety of settings, and wherever there is contact there is the opportunity for interaction to take place. Interaction with companion animals are well known, but human–animal interaction (HAR (Hosey, 2008 also occurs in the context of farms (Hemsworth and Gonyou, 1997; Hemsworth, 2003, laboratories (Chang and Hart, 2002, zoos (Kreger and Mench, 1995 and even the wild (e.g. Cassini, 2001. This project proposes a permanent monitoring scheme to record animal-human interactions and animal-animal interactions in zoos. This will be accompanied by a survey of animal personality for welfare, husbandry, breeding programs and reintroduction purposes. The pilot project is currently based on direct monitoring of animal behaviour, use of time lapse cameras and animal personality questionnaires completed by experienced keepers. The goal of this project is to create a network between zoos to explore the aforementioned interactions to produce husbandry protocols and explore personality and behavioural traits in multiple species. We present provisional data regarding polar bear (Fasano Zoosafari, Italy, Sumatran tigers, Amur tigers and Asiatic lion (ZSL London and Whipsnade zoo interactions with humans and conspecifics. This data is collected across a broad range of environmental conditions and outlines the monitoring protocols developed to collect this data. The first year data show the great adaptability of these species to ex situ environments, low or absent negative impact of visitors’ presence and the relevance of individual personality in these interactions.

  19. Behavioural biology: an effective and relevant conservation tool.

    Science.gov (United States)

    Buchholz, Richard

    2007-08-01

    'Conservation behaviour' is a young discipline that investigates how proximate and ultimate aspects of the behaviour of an animal can be of value in preventing the loss of biodiversity. Rumours of its demise are unfounded. Conservation behaviour is quickly building a capacity to positively influence environmental decision making. The theoretical framework used by animal behaviourists is uniquely valuable to elucidating integrative solutions to human-wildlife conflicts, efforts to reintroduce endangered species and reducing the deleterious effects of ecotourism. Conservation behaviourists must join with other scientists under the multidisciplinary umbrella of conservation biology without giving up on their focus: the mechanisms, development, function and evolutionary history of individual differences in behaviour. Conservation behaviour is an increasingly relevant tool in the preservation of nature.

  20. Qualitative assessment of temporal fluctuations on buffalo behaviour

    Directory of Open Access Journals (Sweden)

    Maria Serrapica

    2014-12-01

    Full Text Available The qualitative assessment of animal behaviour (QBA is an integrative, whole-animal methodology based on the qualitative interpretation of the dynamic style in which animals interact with their environment. In other words, it describes not what the animals do, but how they do what they do. We aimed to verify whether the QBA was able to detect the behavioural fluctuations occurring in animals in response to an environmental challenge. An 8-member panel was used. The panel was briefly trained on the temporal dominance of sensations (TDS procedure and subsequently asked to observe the behaviour of 4 buffalo heifers in 4 videos lasting 2 min each and score the behavioural expression of the animals following the TDS procedure. TDS consists in presenting to the panellist the list of behavioural descriptors on a computer screen along with each video. Each video was obtained by assembling two clips concerning the same animal in two different conditions: home indoor pen (1 min and novel outdoor paddock (1 min. Two videos started with the animal in the outdoor environment and two others in the opposite order. Six behavioural descriptors were chosen from a previous work conducted on the same animals: calm, active, curious, nervous, shy and apathetic. Each assessor was asked to select the dominant descriptor, which was considered as dominant when it gained most of the attention of the observer. Each time the observer felt the behaviour changed, he/she scored the new dominant descriptor until the behaviour ended. Each video was observed 4 times by each observer (4 replications in a randomised order at 24-h intervals. For each point of time, the proportion of runs (subject × replication for which a given descriptor was assessed as dominant (dominance rate >30% was computed. Results showed a satisfactory agreement among observers and replications. The observers clearly discriminated the first from the second half of each video. Calm and apathetic were

  1. Animating Brains

    Science.gov (United States)

    Borck, Cornelius

    2016-01-01

    A recent paper famously accused the rising field of social neuroscience of using faulty statistics under the catchy title ‘Voodoo Correlations in Social Neuroscience’. This Special Issue invites us to take this claim as the starting point for a cross-cultural analysis: in which meaningful ways can recent research in the burgeoning field of functional imaging be described as, contrasted with, or simply compared to animistic practices? And what light does such a reading shed on the dynamics and effectiveness of a century of brain research into higher mental functions? Reviewing the heated debate from 2009 around recent trends in neuroimaging as a possible candidate for current instances of ‘soul catching’, the paper will then compare these forms of primarily image-based brain research with older regimes, revolving around the deciphering of the brain’s electrical activity. How has the move from a decoding paradigm to a representational regime affected the conceptualisation of self, psyche, mind and soul (if there still is such an entity)? And in what ways does modern technoscience provide new tools for animating brains? PMID:27292322

  2. Behavioural consistency and life history of Rana dalmatina tadpoles.

    Science.gov (United States)

    Urszán, Tamás János; Török, János; Hettyey, Attila; Garamszegi, László Zsolt; Herczeg, Gábor

    2015-05-01

    The focus of evolutionary behavioural ecologists has recently turned towards understanding the causes and consequences of behavioural consistency, manifesting either as animal personality (consistency in a single behaviour) or behavioural syndrome (consistency across more behaviours). Behavioural type (mean individual behaviour) has been linked to life-history strategies, leading to the emergence of the integrated pace-of-life syndrome (POLS) theory. Using Rana dalmatina tadpoles as models, we tested if behavioural consistency and POLS could be detected during the early ontogenesis of this amphibian. We targeted two ontogenetic stages and measured activity, exploration and risk-taking in a common garden experiment, assessing both individual behavioural type and intra-individual behavioural variation. We observed that activity was consistent in all tadpoles, exploration only became consistent with advancing age and risk-taking only became consistent in tadpoles that had been tested, and thus disturbed, earlier. Only previously tested tadpoles showed trends indicative of behavioural syndromes. We found an activity-age at metamorphosis POLS in the previously untested tadpoles irrespective of age. Relative growth rate correlated positively with the intra-individual variation of activity of the previously untested older tadpoles. In previously tested older tadpoles, intra-individual variation of exploration correlated negatively and intra-individual variation of risk-taking correlated positively with relative growth rate. We provide evidence for behavioural consistency and POLS in predator- and conspecific-naive tadpoles. Intra-individual behavioural variation was also correlated to life history, suggesting its relevance for the POLS theory. The strong effect of moderate disturbance related to standard behavioural testing on later behaviour draws attention to the pitfalls embedded in repeated testing.

  3. Feeding and welfare of domestic animals: A Darwinistic framework

    NARCIS (Netherlands)

    Koene, P.

    2006-01-01

    This chapter explores the natural feeding behaviour, domestic feeding, behavioural problems related to feeding in captivity and welfare of domestic animals, particularly cattle, horse and chicken. The solutions for feeding problems and poor welfare are discussed. The concept of environment of evolut

  4. Moving Child Abuse and Neglect Prevention Programs Forward: Improving Program Evaluations.

    Science.gov (United States)

    Fink, Arlene; McCloskey, Lois

    1990-01-01

    Thirteen evaluations of programs to prevent child abuse and neglect are reviewed. The evaluations were characterized by careful attention to methodologic detail but lacked definitions of abuse or neglect. Important topics are omitted, such as the consequences and costs of medical neglect. (Author/JDD)

  5. Goal Neglect and Spearman's "g": Competing Parts of a Complex Task

    Science.gov (United States)

    Duncan, John; Parr, Alice; Woolgar, Alexandra; Thompson, Russell; Bright, Peter; Cox, Sally; Bishop, Sonia; Nimmo-Smith, Ian

    2008-01-01

    In goal neglect, a person ignores some task requirement though being able to describe it. Goal neglect is closely related to general intelligence or C. Spearman's (1904) "g" (J. Duncan, H. Emslie, P. Williams, R. Johnson, & C. Freer, 1996). The authors tested the role of task complexity in neglect and the hypothesis that different task components…

  6. 25 CFR 20.516 - How are child abuse, neglect or exploitation cases to be handled?

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How are child abuse, neglect or exploitation cases to be... FINANCIAL ASSISTANCE AND SOCIAL SERVICES PROGRAMS Child Assistance Foster Care § 20.516 How are child abuse, neglect or exploitation cases to be handled? Reported child abuse, neglect or exploitation cases and...

  7. Themes from a Grounded Theory Analysis of Elder Neglect Assessment by Experts

    Science.gov (United States)

    Fulmer, Terry; Firpo, Adolfo; Guadagno, Lisa; Easter, Tara M.; Kahan, Fay; Paris, Barbara

    2003-01-01

    Purpose: This paper describes one program that has developed a screening procedure for assessing elder mistreatment, with a special focus on elder neglect. The aim is to understand how expert neglect assessment teams process and diagnose complex geriatric cases referred for suspected elder neglect. What are the key themes that must be understood…

  8. Assessment of Visuospatial Neglect in Stroke Patients Using Virtual Reality: A Pilot Study

    Science.gov (United States)

    Jannink, Michiel J. A.; Aznar, Miguel; de Kort, Alexander Cornelis; van de Vis, Wim; Veltink, Peter; van der Kooij, Herman

    2009-01-01

    One of the neuropsychological deficits that can result from a stroke is the neglect phenomenon. Neglect has traditionally been assessed with paper-and-pencil tasks, which are administered within the reaching space of a person. The purpose of this explorative study is to investigate whether it is possible to assess neglect in the extrapersonal…

  9. Behavioural present value

    OpenAIRE

    Krzysztof Piasecki

    2013-01-01

    Impact of chosen behavioural factors on imprecision of present value is discussed here. The formal model of behavioural present value is offered as a result of this discussion. Behavioural present value is described here by fuzzy set. These considerations were illustrated by means of extensive numerical case study. Finally there are shown that in proposed model the return rate is given, as a fuzzy probabilistic set.

  10. Incentives and Prosocial Behaviour

    OpenAIRE

    Bénabou, Roland; Tirole, Jean

    2004-01-01

    We build a theory of prosocial behaviour that combines heterogeneity in individual altruism and greed with concerns for social reputation or self-respect. The presence of rewards or punishments creates doubt as to the true motive for which good deeds are performed, and this ‘overjustification effect’ can result in a net crowding out of prosocial behaviour by extrinsic incentives. The model also allows us to identify settings that are conducive to multiple social norms of behaviour, and those ...

  11. Cocaine affects foraging behaviour and biogenic amine modulated behavioural reflexes in honey bees

    Directory of Open Access Journals (Sweden)

    Eirik Søvik

    2014-11-01

    Full Text Available In humans and other mammals, drugs of abuse alter the function of biogenic amine pathways in the brain leading to the subjective experience of reward and euphoria. Biogenic amine pathways are involved in reward processing across diverse animal phyla, however whether cocaine acts on these neurochemical pathways to cause similar rewarding behavioural effects in animal phyla other than mammals is unclear. Previously, it has been shown that bees are more likely to dance (a signal of perceived reward when returning from a sucrose feeder after cocaine treatment. Here we examined more broadly whether cocaine altered reward-related behaviour, and biogenic amine modulated behavioural responses in bees. Bees developed a preference for locations at which they received cocaine, and when foraging at low quality sucrose feeders increase their foraging rate in response to cocaine treatment. Cocaine also increased reflexive proboscis extension to sucrose, and sting extension to electric shock. Both of these simple reflexes are modulated by biogenic amines. This shows that systemic cocaine treatment alters behavioural responses that are modulated by biogenic amines in insects. Since insect reward responses involve both octopamine and dopamine signalling, we conclude that cocaine treatment altered diverse reward-related aspects of behaviour in bees. We discuss the implications of these results for understanding the ecology of cocaine as a plant defence compound. Our findings further validate the honey bee as a model system for understanding the behavioural impacts of cocaine, and potentially other drugs of abuse.

  12. Animal welfare: neuro-cognitive approaches

    Directory of Open Access Journals (Sweden)

    Massimo Morgante

    2010-01-01

    Full Text Available Many people maintain a naive belief that non-human animals consciously experience pain and suffering in similar ways to humans. Others tend to assume a more sceptical or agnostic attitude. Drawing on recent advances in research on animal cognition and neuroscience, the science of animal welfare is now beginning to address these issues empirically. We describe recent advances that may contribute to the main questions of animal welfare, namely whether animals are conscious and how we can assess good and bad welfare in animals. Evidence from psychology is described which demonstrate that many complex actions in humans can be carried out quite unconsciously and that human patients with certain sorts of brain damage can behave and manipulate objects properly while at the same time o consciously denying experience of them. The relevance of these findings with respect to the issue of animal consciousness is discussed. Evidence from animal cognition is described concerning the possibility that animals monitor the state of their own memories, show episodic-like knowledge and exhibit self-medication. Evidence from neuroscience concerning brain lateralization in non-human animals and its relevance to animal welfare is described. It is argued that in animals raised for economic purposes (milk and meat production differences in cognitive abilities and brain lateralization can affect adaptive behavioural, physiological and immune responses to environmental stressors.

  13. Scaling and Intermittency in Animal Behavior

    CERN Document Server

    Harnos, A; Lawrence, A B; Vattay, G

    1999-01-01

    Scale-invariant spatial or temporal patterns and Lévy flight motion have been observed in a large variety of biological systems. It has been argued that animals in general might perform Lévy flight motion with power law distribution of times between two changes of the direction of motion. Here we study the temporal behaviour of nesting gilts. The time spent by a gilt in a given form of activity has power law probability distribution without finite average. Further analysis reveals intermittent eruption of certain periodic behavioural sequences which are responsible for the scaling behaviour and indicates the existence of a critical state. We show that this behaviour is in close analogy with temporal sequences of velocity found in turbulent flows, where random and regular sequences alternate and form an intermittent sequence.

  14. Preliminary observations on behaviour of limousine and highland cattle

    Directory of Open Access Journals (Sweden)

    Jarosław Pytlewski

    2011-09-01

    Full Text Available The aim of the study was to characterise behaviour of limousine and highland cattle kept on permanent grassland on a farm in the Wielkopolska region. Investigations consisted of observations conducted on the behaviour of animals in two herds of limousine and highland cattle during the four seasons of the year. Frequency was recorded for the following activities performed by animals: food consumption, drinking of water, rumination, resting (lying down, rubbing, allolicking, fights and excretion (urine, faeces. The second stage of the study comprised detailed descriptions of behaviour of animals on the pasture. Observations were conducted on a herd composed of dams, juvenile animals (up to seven-eight months old and a bull.

  15. Self-neglect: a case study and implications for clinical practice.

    LENUS (Irish Health Repository)

    Day, Mary Rose

    2015-03-02

    Self-neglect is a worldwide and serious public health issue that can have serious adverse outcomes and is more common in older people. Cases can vary in presentation, but typically present as poor self-care, poor care of the environment and service refusal. Community nurses frequently encounter self-neglect cases and health and social care professionals play a key role in the identification, management and prevention of self-neglect. Self-neglect cases can give rise to ethical, personal and professional challenges. The aim of this article is to create a greater understanding of the concept of self-neglect among community nurses.

  16. Social sciences research in neglected tropical diseases 3: Investment in social science research in neglected diseases of poverty: a case study of Bill and Melinda Gates Foundation

    Directory of Open Access Journals (Sweden)

    Reidpath Daniel

    2011-01-01

    Full Text Available Abstract Background The level of funding provides a good proxy for the level of commitment or prioritisation given to a particular issue. While the need for research relevant to social, economic, cultural and behavioural aspects of neglected tropical diseases (NTD control has been acknowledged, there is limited data on the level of funding that supports NTD social science research. Method A case study was carried out in which the spending of a major independent funder, the Bill and Melinda Gates Foundation (BMGF - was analysed. A total of 67 projects funded between October 1998 and November 2008 were identified from the BMGF database. With the help of keywords within the titles of 67 grantees, they were categorised as social science or non-social science research based on available definition of social science. A descriptive analysis was conducted. Results Of 67 projects analysed, 26 projects (39% were social science related while 41 projects (61% were basic science or other translational research including drug development. A total of US$ 697 million was spent to fund the projects, of which 35% ((US$ 241 million went to social science research. Although the level of funding for social science research has generally been lower than that for non-social science research over 10 year period, social science research attracted more funding in 2004 and 2008. Conclusion The evidence presented in this case study indicates that funding on NTD social science research compared to basic and translational research is not as low as it is perceived to be. However, as there is the acute need for improved delivery and utilisation of current NTD drugs/technologies, informed by research from social science approaches, funding priorities need to reflect the need to invest significantly more in NTD social science research.

  17. The influence of the owner on the development of aggressive behaviour in dogs

    OpenAIRE

    2001-01-01

    Aggressive behaviour in dogs has become a major topic of scientific research in Northern Europe, particularly in England and France, and also in the USA. It ranks amongst the top problems presented to animal behaviour therapists. Research into the influence of owner’s interactions with their dog on the development of the dog’s behaviour in general and problem behaviour, including aggression in particular, has yielded contradictory results. While some authors could not establish significant li...

  18. Animal personality, behaviour or traits: What are we measuring?

    NARCIS (Netherlands)

    Van Oers, K.

    2008-01-01

    With the development of a new bottom-up methodology, the author aims at providing its with a tool for comparative personality research. This tool will indeed help us to identify differences between related species. However, to understand how differences within species are maintained and differences

  19. Stabilization of behaviours

    NARCIS (Netherlands)

    Geest, van der Robert

    1996-01-01

    In this paper we characterize the set of all restrictions on the behaviour of a plant that shape the characteristic polynomial of the closed-loop system. These control laws include both classical feedback laws and singular feedback laws. One of the results is the behavioural version of the Youla-Jab

  20. Isometric thermogenesis at rest and during movement: a neglected variable in energy expenditure and obesity predisposition.

    Science.gov (United States)

    Dulloo, A G; Miles-Chan, J L; Montani, J-P; Schutz, Y

    2017-02-01

    Isometric thermogenesis as applied to human energy expenditure refers to heat production resulting from increased muscle tension. While most physical activities consist of both dynamic and static (isometric) muscle actions, the isometric component is very often essential for the optimal performance of dynamic work given its role in coordinating posture during standing, walking and most physical activities of everyday life. Over the past 75 years, there has been sporadic interest into the relevance of isometric work to thermoregulatory thermogenesis and to adaptive thermogenesis pertaining to body-weight regulation. This has been in relation to (i) a role for skeletal muscle minor tremor or microvibration - nowadays referred to as 'resting muscle mechanical activity' - in maintaining body temperature in response to mild cooling; (ii) a role for slowed skeletal muscle isometric contraction-relaxation cycle as a mechanism for energy conservation in response to caloric restriction and weight loss and (iii) a role for spontaneous physical activity (which is contributed importantly by isometric work for posture maintenance and fidgeting behaviours) in adaptive thermogenesis pertaining to weight regulation. This paper reviews the evidence underlying these proposed roles for isometric work in adaptive thermogenesis and highlights the contention that variability in this neglected component of energy expenditure could contribute to human predisposition to obesity.

  1. Integrated health messaging for multiple neglected zoonoses: Approaches, challenges and opportunities in Morocco.

    Science.gov (United States)

    Ducrotoy, M J; Yahyaoui Azami, H; El Berbri, I; Bouslikhane, M; Fassi Fihri, O; Boué, F; Petavy, A F; Dakkak, A; Welburn, S; Bardosh, K L

    2015-12-01

    Integrating the control of multiple neglected zoonoses at the community-level holds great potential, but critical data is missing to inform the design and implementation of different interventions. In this paper we present an evaluation of an integrated health messaging intervention, using powerpoint presentations, for five bacterial (brucellosis and bovine tuberculosis) and dog-associated (rabies, cystic echinococcosis and leishmaniasis) zoonotic diseases in Sidi Kacem Province, northwest Morocco. Conducted by veterinary and epidemiology students between 2013 and 2014, this followed a process-based approach that encouraged sequential adaptation of images, key messages, and delivery strategies using auto-evaluation and end-user feedback. We describe the challenges and opportunities of this approach, reflecting on who was targeted, how education was conducted, and what tools and approaches were used. Our results showed that: (1) replacing words with local pictures and using "hands-on" activities improved receptivity; (2) information "overload" easily occurred when disease transmission pathways did not overlap; (3) access and receptivity at schools was greater than at the community-level; and (4) piggy-backing on high-priority diseases like rabies offered an important avenue to increase knowledge of other zoonoses. We conclude by discussing the merits of incorporating our validated education approach into the school curriculum in order to influence long-term behaviour change.

  2. Listeriosis in the far South of Brazil: neglected infection?

    Directory of Open Access Journals (Sweden)

    Dulcinea Blum-Menezes

    2013-06-01

    Full Text Available Listeriosis is an under-diagnosed and under-reported infection; however, listeriosis is not a compulsorily notifiable disease in Brazil. We provide an overview of the rates of listeriosis in the United States of America (USA, Europe, Latin America, and Brazil during the past decade. We also report a case of miscarriage caused by listeriosis in which there was no suspicion of this infection. This overview and the case we report serve as reminders of the often-neglected threat of listeriosis and its potential to cause miscarriage while highlighting the necessity of recognizing listeriosis as a compulsorily notifiable disease in Brazil.

  3. The confederate's and others' self-conversion: a neglected phenomenon.

    Science.gov (United States)

    Laurens, Stéphane; Moscovici, Serge

    2005-04-01

    The authors analyzed a neglected phenomenon: self-conversion. Rather than concentrating on the influence exerted by a confederate on a naive participant, the authors studied how the confederate is himself or herself influenced by the position that he or she defends at the request of the experimenter. This experiment is particularly revealing with respect to a fundamental aspect of the psychology of the proselytizing of minority groups: In the process of convincing others, one also convinces oneself. Exerting influence on others thus leads to self-conversion, which allows the group to reinforce its beliefs and to stand up to conformity pressures.

  4. One Health and the neglected zoonoses: turning rhetoric into reality.

    Science.gov (United States)

    Okello, Anna L; Gibbs, E Paul J; Vandersmissen, Alain; Welburn, Susan C

    2011-09-10

    Successful adoption of a One Health approach could have far-reaching impacts on poverty alleviation, health and food security, particularly in developing countries through integrated control of neglected zoonoses. However, the practical implementation of this approach presents many challenges. Anna Okello and colleagues argue that, for effective implementation, lessons learned and 'best practice' must be led by national and regional stakeholders drawn from a variety of disciplines. High-profile regional and international institutions can play an important role in the global governance of One Health by encouraging individual countries to devise appropriate tailored solutions that are workable within their own context.

  5. Reconstruction of neglected patellar tendon ruptures using the quadriceps graft.

    Science.gov (United States)

    Gomes, João Luiz Ellera; de Oliveira Alves, Jairo André; Zimmermann, José Mauro

    2014-08-01

    Several techniques using different grafts have been described for reconstruction of the patellar tendon after a neglected rupture. Retraction of the quadriceps tendon may compromise repair integrity due to progressive stretching of the graft. The authors present a surgical technique using the central one-third of the quadriceps tendon. This is supported by the fact that the resistance to traction of this segment of the quadriceps tendon equals that of a double-looped semitendinosus graft and that the harvesting of this specific graft promotes muscle inhibition, thus protecting the reconstruction during the recovery period.

  6. The wild animal as a research animal

    NARCIS (Netherlands)

    Swart, JAA

    2004-01-01

    Most discussions on animal experimentation refer to domesticated animals and regulations are tailored to this class of animals. However, wild animals are also used for research, e. g., in biological field research that is often directed to fundamental ecological-evolutionary questions or to conserva

  7. A systematic review of the epidemiology of echinococcosis in domestic and wild animals.

    Directory of Open Access Journals (Sweden)

    Belen Otero-Abad

    Full Text Available BACKGROUND: Human echinococcosis is a neglected zoonosis caused by parasites of the genus Echinococcus. The most frequent clinical forms of echinococcosis, cystic echinococcosis (CE and alveolar echinococcosis (AE, are responsible for a substantial health and economic burden, particularly to low-income societies. Quantitative epidemiology can provide important information to improve the understanding of parasite transmission and hence is an important part of efforts to control this disease. The purpose of this review is to give an insight on factors associated with echinococcosis in animal hosts by summarising significant results reported from epidemiological studies identified through a systematic search. METHODOLOGY AND PRINCIPAL FINDINGS: The systematic search was conducted mainly in electronic databases but a few additional records were obtained from other sources. Retrieved entries were examined in order to identify available peer-reviewed epidemiological studies that found significant risk factors for infection using associative statistical methods. One hundred studies met the eligibility criteria and were suitable for data extraction. Epidemiological factors associated with increased risk of E. granulosus infection in dogs included feeding with raw viscera, possibility of scavenging dead animals, lack of anthelmintic treatment and owners' poor health education and indicators of poverty. Key factors associated with E. granulosus infection in intermediate hosts were related to the hosts' age and the intensity of environmental contamination with parasite eggs. E. multilocularis transmission dynamics in animal hosts depended on the interaction of several ecological factors, such as hosts' population densities, host-prey interactions, landscape characteristics, climate conditions and human-related activities. CONCLUSIONS/SIGNIFICANCE: Results derived from epidemiological studies provide a better understanding of the behavioural, biological and

  8. Health care provision for older persons: the interplay between ageism and elder neglect.

    Science.gov (United States)

    Band-Winterstein, Tova

    2015-04-01

    The aim of this study was to explore the link between neglect and ageism in health care provision for older persons. Semistructured in-depth interviews were conducted with 30 registered nurses with at least 2 years' experience in 10 long-term care facilities in Israel. Interviews were digitally recorded and transcribed verbatim. Data analysis was performed according to the qualitative method. Three main themes emerged: ageism and neglect as the everyday routine (neglect is built into institution life on the platform of ageism); how the institutional system promotes neglect--between institutional and personal ageism (the ways institutions promote neglect in the shadow of ageism); from vision to reality--how neglect can be prevented in an ageist reality. The attempt to demonstrate the link between ageism and neglect and suggesting how to include them as interrelated phenomena in health care provision programs could promote older persons' quality of life.

  9. Behavioural aspects of terrorism.

    Science.gov (United States)

    Leistedt, Samuel J

    2013-05-10

    Behavioural and social sciences are useful in collecting and analysing intelligence data, understanding terrorism, and developing strategies to combat terrorism. This article aims to examine the psychopathological concepts of terrorism and discusses the developing roles for behavioural scientists. A systematic review was conducted of studies investigating behavioural aspects of terrorism. These studies were identified by a systematic search of databases, textbooks, and a supplementary manual search of references. Several fundamental concepts were identified that continue to influence the motives and the majority of the behaviours of those who support or engage in this kind of specific violence. Regardless of the psychological aspects and new roles for psychiatrists, the behavioural sciences will continue to be called upon to assist in developing better methods to gather and analyse intelligence, to understand terrorism, and perhaps to stem the radicalisation process.

  10. The globalisation of farm animal welfare.

    Science.gov (United States)

    Fraser, D

    2014-04-01

    Animal welfare has achieved significant global prominence for perhaps three reasons. First, several centuries of scientific research, especially in anatomy, evolutionary biology and animal behaviour, have led to a gradual narrowing of the gap that people perceive between humans and other species; this altered perception has prompted grass-roots attention to animals and their welfare, initially in Western countries but now more globally asthe influence of science has expanded. Second, scientific research on animal welfare has provided insights and methods for improving the handling, housing and management of animals; this 'animal welfare science' is increasingly seen as relevant to improving animal husbandry worldwide. Third, the development and use of explicit animal welfare standards has helped to integrate animal welfare as a component of national and international public policy, commerce and trade. To date, social debate about animal welfare has been dominated bythe industrialised nations. However, as the issue becomes increasingly global, it will be important for the non-industrialised countries to develop locally appropriate approaches to improving animal welfare, for example, by facilitating the provision of shelter, food, water and health care, and by improving basic handling, transportation and slaughter.

  11. Natural selection can favour 'irrational' behaviour.

    Science.gov (United States)

    McNamara, J M; Trimmer, P C; Houston, A I

    2014-01-01

    Understanding decisions is the fundamental aim of the behavioural sciences. The theory of rational choice is based on axiomatic principles such as transitivity and independence of irrelevant alternatives (IIA). Empirical studies have demonstrated that the behaviour of humans and other animals often seems irrational; there can be a lack of transitivity in choice and seemingly irrelevant alternatives can alter decisions. These violations of transitivity and IIA undermine rational choice theory. However, we show that an individual that is maximizing its rate of food gain can exhibit failure of transitivity and IIA. We show that such violations can be caused because a current option may disappear in the near future or a better option may reappear soon. Current food options can be indicative of food availability in the near future, and this key feature can result in apparently irrational behaviour.

  12. Modelling Virtual Camera Behaviour Through Player Gaze

    DEFF Research Database (Denmark)

    Picardi, Andrea; Burelli, Paolo; Yannakakis, Georgios N.

    2012-01-01

    In a three-dimensional virtual environment, aspects such as narrative and interaction largely depend on the placement and animation of the virtual camera. Therefore, virtual camera control plays a critical role in player experience and, thereby, in the overall quality of a computer game. Both game...... industry and game AI research focus on the devel- opment of increasingly sophisticated systems to automate the control of the virtual camera integrating artificial intel- ligence algorithms within physical simulations. However, in both industry and academia little research has been carried out...... on the relationship between virtual camera, game-play and player behaviour. We run a game user experiment to shed some light on this relationship and identify relevant dif- ferences between camera behaviours through different game sessions, playing behaviours and player gaze patterns. Re- sults show that users can...

  13. The relative importance of habitual and deliberative factors in food consumer behaviour

    DEFF Research Database (Denmark)

    Scholderer, Joachim; Olsen, Svein Ottar; Brunsø, Karen

    2006-01-01

    (total N = 4800). Extended theory of planned behaviour specifications were estimated that included habit as an exogenous variable. The results indicated that habit predicted attitude, subjective norm, and perceived control far better than these could in turn predict intention and behaviour, apparently......Rational-choice approaches to consumer behaviour neglect the influence of habitual factors. Previous research outside the food choice area has found that habitual factors tend to dominate when the target behaviour is performed often and in stable contexts, whilst deliberative factors tend...... to dominate when the target behaviour is performed rarely and in unstable contexts. In the food choice area, only little research exists that would allow a similar assessment. As part of the SEAFOODplus project, representative surveys were conducted in Belgium, Denmark, Spain, the Netherlands, and Poland...

  14. Animation of Antimicrobial Resistance

    Medline Plus

    Full Text Available ... Veterinary Home Animal & Veterinary Safety & Health Antimicrobial Resistance Animation of Antimicrobial Resistance Share Tweet Linkedin Pin it ... Veterinary Medicine is cited as the corporate author. Animation Animation of Antimicrobial Resistance (WMV - 19.2MB) 9: ...

  15. Life-history trade-offs favour the evolution of animal personalities

    NARCIS (Netherlands)

    Wolf, M.; Van Doorn, G.S.; Leimar, O.; Weissing, F.J.

    2007-01-01

    In recent years evidence has been accumulating that personalities are not only found in humans(1) but also in a wide range of other animal species(2-8). Individuals differ consistently in their behavioural tendencies and the behaviour in one context is correlated with the behaviour in multiple other

  16. Multidisciplinary Teams in Child Abuse and Neglect Programs. A Special Report from the National Center on Child Abuse and Neglect, August, 1978.

    Science.gov (United States)

    Herner and Co., Washington, DC.

    The monograph examines the rationale and scope of multidisciplinary teams in child abuse and neglect cases; and reviews operation of hospital-based, interagency, and state-mandated multidisciplinary team programs. The bulk of the document is composed of two appendixes: a directory of child abuse and neglect programs which use a multidisciplinary…

  17. Synchronous behaviour of cetaceans observed with active acoustics

    Science.gov (United States)

    Godø, Olav Rune; Sivle, Lise Doksæter; Patel, Ruben; Torkelsen, Terje

    2013-12-01

    Scientific split-beam echosounders are sensitive instruments for observing biomass densities and individual behaviour. Earlier studies have demonstrated that these instruments can be used to study diving behaviour of cetaceans. In this paper, we go into more detail about the recorded signal to see if and how acoustic split-beam data can be used to extract information about synchronous behaviour and other species related characteristics. Data of several cetacean individuals were collected by a moored echosounder pinging upwards from about 900 m in the Charlie Gibbs Fracture Zone. In this paper, we discuss methodological issues associated with using split-beam tracking of large marine animals. Further we demonstrate that target tracking of cetaceans can be used to study solo dives as well as behavioural synchrony. We also show that paired signals can easily be interpreted as false synchrony due to the size of the animals. In such cases a rough estimate of the diameter, and hence size, of the animals can be estimated. We emphasise on four examples that clarify methodological challenges including synchronous swimmers as well as large single cetaceans that might be interpreted as two synchronous swimmers. The applied technology requires that the animals remain in a narrow acoustic beam for long enough time to extract behavioural information. The technology can be improved by developing automatic tracking of cetaceans with a steerable transducer. This will substantially increase the search volume and enable tracking of cetaceans over longer periods and thus, produce more realistic information about the whale behaviour.

  18. Learning Anime Studio

    CERN Document Server

    Troftgruben, Chad

    2014-01-01

    Anime Studio is your complete animation program to help you create 2D movies, cartoons, anime, and cut out animations. You can create your own animated shorts and use Anime Studio to produce cartoon animations for film, video, or streaming over the Web, which can be enjoyed on YouTube, Vimeo, and other popular sites. Anime Studio is great for hobbyists and professionals alike, combining tools for both illustration and animation. With Anime Studio's easy-to-use interface, you will be creating an animated masterpiece in no time. This practical, step-by-step guide will provide you with a structur

  19. Empirical questions for collective-behaviour modelling

    Indian Academy of Sciences (India)

    Nicholas T Ouellette

    2015-03-01

    The collective behaviour of groups of social animals has been an active topic of study across many disciplines, and has a long history of modelling. Classical models have been successful in capturing the large-scale patterns formed by animal aggregations, but fare less well in accounting for details, particularly for groups that do not display net motion. Inspired by recent measurements of swarming insects, which are not well described by the classical modelling paradigm, I pose a set of questions that must be answered by any collective-behaviour model. By explicitly stating the choices made in response to each of these questions, models can be more easily categorized and compared, and their expected range of validity can be clarified.

  20. Influence of age and sex on line bisection: a study of normal performance with implications for visuospatial neglect.

    Science.gov (United States)

    Varnava, Alice; Halligan, Peter W

    2007-11-01

    Line bisection is an established clinical task used to diagnose visuospatial neglect. To date, few studies have considered the extent to which age and sex as background variables contribute to bisection performance. Both variables affect the neural substrates underlying cognitive processes and hence the behavioural performance of bisection. The purpose of this study was to examine the effects of age and sex on normal bisection performance, using three different line lengths to elucidate the influence of these potential contributing factors. Seventy men and 70 women, divided equally into seven age-cohorts between 14 and 80 years, bisected lines. Results indicated clear age- and sex-related differences both in the magnitude and direction of bisection deviations across the three line lengths. Differences are discussed in terms of neural changes across the adult lifespan including hemispheric differences and hormonally mediated changes.

  1. Detecting elder abuse and neglect: assessment and intervention.

    Science.gov (United States)

    Hoover, Robert M; Polson, Michol

    2014-03-15

    Elder mistreatment includes intentional or neglectful acts by a caregiver or trusted person that harm a vulnerable older person. It can occur in a variety of settings. One out of 10 older adults experiences some form of abuse or neglect by a caregiver each year, and the incidence is expected to increase. Although the U.S. Preventive Services Task Force found insufficient evidence that screening for elder abuse reduces harm, physicians in most states have professional and legal obligations to appropriately diagnose, report, and refer persons who have been abused. Screening or systematic inquiry can detect abuse. A detailed medical evaluation of patients suspected of being abused is necessary because medical and psychiatric conditions can mimic abuse. Signs of abuse may include specific patterns of injury. Interviewing patients and caregivers separately is helpful. Evaluation for possible abuse should include assessment of cognitive function. The Elder Abuse Suspicion Index is validated to screen for abuse in cognitively intact patients. A more detailed two-step process is used to screen patients with cognitive impairment. The National Center on Elder Abuse website provides detailed, state-specific reporting and resource information for family physicians.

  2. Neglected tropical diseases in Africa: a new paradigm.

    Science.gov (United States)

    Hopkins, Adrian D

    2016-03-01

    Programmes to control onchocerciasis have been ongoing for over 40 years. What was once a devastating blinding and disabling disease, particularly in West Africa, has largely been eliminated at least as a public health problem. Efforts continue to eliminate the transmission of the disease. However, as the elimination agenda has developed so have efforts to control/eliminate other neglected tropical diseases (NTDs). The African Programme for Onchocerciasis Control will close at the end of 2015. There has been considerable discussion as to what should replace it and the World Health Organization Africa Region has been consulting widely during the first part of 2015 and has established a new project framework that will be presented to a wider group of stakeholders to mobilise support with the aim of the coordination of NTD activities in the region. This will be called the Expanded Special Project for Elimination of Neglected Tropical Diseases (ESPEN). This will put the countries in the driving seat but offer technical advice, capacity building and financial support, where needed, to enable countries to implement their NTD Master Plans, and also to implement recommendations of the Regional Programme Review Group. An NTD forum will be held periodically to consult with stakeholders.

  3. Neglect dyslexia: a review of the neuropsychological literature.

    Science.gov (United States)

    Vallar, Giuseppe; Burani, Cristina; Arduino, Lisa S

    2010-10-01

    Neglect dyslexia (ND) is reviewed, based on published single-patient and group studies. ND is frequently associated with right hemispheric damage and unilateral spatial neglect (USN), and typically involves the left side of the letter string. Left-brain-damaged patients showing ND, ipsilateral (left) or contralateral (right) to the side of the left-sided hemispheric lesion, have also been reported, as well as a few patients with bilateral damage, with more frequently left than right ND. As USN, ND is temporarily ameliorated by lateralized stimulations (vestibular caloric, visual prism adaptation). ND may occur independent of USN, suggesting the damage to specific visuospatial representational/attentional systems, supporting reading. ND errors comprise omission, substitution, and, less frequently, addition of letters on one side of the stimulus, resulting in words or nonwords, also with reference to the stimulus' linguistic features. Patients with ND may show preserved lexical-morphological effects and implicit processing, up to the semantic level, of the misread string. This preserved processing is a feature of ND, shared with the USN syndrome. The mechanisms modulating error type and lexical-morphological effects are partly independent of each other. Different levels of representation of the letter string may be affected, giving rise to egocentric, stimulus-centred, and word-centred patterns of impairment. The anatomical correlates of ND include the temporo-parieto-occipital regions.

  4. Neglect and extinction in kinesthesia and thesesthesia: understanding proprioceptive inattention.

    Science.gov (United States)

    Karageorgiou, Elissaios

    2016-01-01

    This paper describes a new observation of neglect and extinction of kinesthesia and thesesthesia (movement and position imperception), jointly reflecting proprioceptive inattention, in a series of patients with parietal lesions. A prototypical case is discussed in detail and unaddressed aspects of proprioceptive inattention are discussed through findings from four additional cases. Thesesthetic and kinesthetic extinction were tested through simultaneous antidromic vertical displacement of index fingers, while having patients report on finger proprioceptive perception with eyes closed. Patients had variable degrees of proprioceptive inattention affecting a specific limb, but without pallesthetic inattention or somatoagnosia, whereas symptoms often resolved with visual feedback or active limb movements. Findings support that kinesthesia and thesesthesia (a) are subserved by near-identical brain networks, (b) relate more to tactile perception than pallesthesia in higher order cortical areas, and (c) have a somatotopic cortical organization even in association brain areas. Furthermore, proprioceptive extinction and neglect involve (i) "attention network" structures, (ii) either hemisphere, (iii) gray or subcortical white matter damage, (iv) defective vigilance mechanisms possibly through premature habituation of spatiotemporally saturated neural capacitor circuits, and (v) are not the result of somatoagnosia, while (vi) their resolution is observed through reafferent motor-sensory or visual feedback.

  5. Spatial analysis of neglected diseases in Brazil, 2007 to 2009

    Directory of Open Access Journals (Sweden)

    Joyce Mendes de Andrade Schramm

    2016-07-01

    Full Text Available This paper aims to describe a set of epidemiological information regarding the spatial distribution of selected neglected diseases in Brazil from 2007 to 2009 and health care infrastructure and socio-economic indicators 2010. An ecological study of the spatial analysis, based on the incidence of tuberculosis, visceral leishmaniasis, American cutaneous leishmaniasis, malaria and prevalence of leprosy and schistosomiasis. Maps with the spatial distribution of the prevalence and incidence rates were drawn, as well as cluster detection maps, applying spatial statistical analysis techniques. A thematic map with the total distribution of priority municipalities was developed for each disease. Malaria and schistosomiasis had the highest incidence and prevalence rates respectively. All diseases analyzed showed dependence in the spatial correlation measure. A total of 1,630 Brazilians municipalities (29% were considered by the Ministry of Health as a priority to receive control actions for at least one of the studied diseases. North and Northeast regions concentrate municipalities with at least three simultaneous diseases, which overlap with the lowest socio-economic indicators. Spatial analysis studies may contribute to a better planning and organizing health care and services, aiming to reduce the existent gap regarding scientific knowledge on neglected diseases.

  6. [Dangerous marine animals].

    Science.gov (United States)

    Antensteiner, G

    1999-01-01

    Sea-biological basic knowledge for divers is offered only in special lessons for advanced scuba divers. According to statistics, however, five per cent of the deadly diving accidents are caused by underwater organisms. This number could be reduced to a fraction, by correct behaviour during the dive and after an accident. The most frequent accidents with sea animals during water sports are not by unprovoked shark attacks, which cause six deaths world-wide per year on the average, but turn out with usually well camouflaged sea inhabitants, that do not attack humans, rather by their inadvertence coincidentally get in contact with it. The various defense instruments of the often small, inconspicuous organisms reach from teeth over poison stings, pricks, spines, scalpelles, nettle injections and chemical weapons up to poison arrows. Due to that variety of the maritime life, the most important representatives of its type are explained including severity level of the caused injury or contamination. Both, diagnostic position and therapy possibility are described as follows: 1. Porifera (sponge), 2. Hydrozoa (white weed, yellow flower head), Actinaria (sea anemones), 3. Conidae (cone shells), Tridocna (giant clam), octopoda (octopus), 4. Acanthaster planci (crown of thorns), Echinodea (sea urchins), Holothurioidea (sea cucumber), 5. Selachoidei (shark), Batoidei (Ray), Muraenidae (moray), Plotosidae (barbel eels), Synanciidae (stonefish), Scorpaenidae (scorpionfish), Pterois (lion fish), Sphyraena Spec. (barracuda), Balistidae (triggerfish), Ostracionidae (puffer).

  7. "Disgusting" Animals: Primary School Children's Attitudes and Myths of Bats and Spiders

    Science.gov (United States)

    Prokop, Pavol; Tunnicliffe, Sue Dale

    2008-01-01

    Knowledge of animals may influence children's beliefs and behaviour toward them, thus building positive attitudes toward animals is one of main goals of environmental education programmes. Although keeping animals contributes to the increase of children's positive attitudes toward wild animals, pet owners show similar negative attitudes toward…

  8. Changing Information Retrieval Behaviours

    DEFF Research Database (Denmark)

    Constantiou, Ioanna D.; Lehrer, Christiane; Hess, Thomas

    2014-01-01

    The introduction of smartphones and the accompanying profusion of mobile data services have had a profound effect on individuals' lives. One of the most influential service categories is location-based services (LBS). Based on insights from behavioural decision-making, a conceptual framework is d...... on the continuance of LBS use and indicate changes in individuals' information retrieval behaviours in everyday life. In particular, the distinct value dimension of LBS in specific contexts of use changes individuals' behaviours towards accessing location-related information....

  9. Animal models of anxiety: an ethological perspective

    Directory of Open Access Journals (Sweden)

    Rodgers R.J.

    1997-01-01

    Full Text Available In the field of anxiety research, animal models are used as screening tools in the search for compounds with therapeutic potential and as simulations for research on mechanisms underlying emotional behaviour. However, a solely pharmacological approach to the validation of such tests has resulted in distinct problems with their applicability to systems other than those involving the benzodiazepine/GABAA receptor complex. In this context, recent developments in our understanding of mammalian defensive behaviour have not only prompted the development of new models but also attempts to refine existing ones. The present review focuses on the application of ethological techniques to one of the most widely used animal models of anxiety, the elevated plus-maze paradigm. This fresh approach to an established test has revealed a hitherto unrecognized multidimensionality to plus-maze behaviour and, as it yields comprehensive behavioural profiles, has many advantages over conventional methodology. This assertion is supported by reference to recent work on the effects of diverse manipulations including psychosocial stress, benzodiazepines, GABA receptor ligands, neurosteroids, 5-HT1A receptor ligands, and panicolytic/panicogenic agents. On the basis of this review, it is suggested that other models of anxiety may well benefit from greater attention to behavioural detail

  10. Breed differences in behavioural development in kittens.

    Science.gov (United States)

    Marchei, P; Diverio, S; Falocci, N; Fatjó, J; Ruiz-de-la-Torre, J L; Manteca, X

    2009-03-23

    Differences in behaviour of pure breed cats have been suggested but not wholly investigated. Oriental/Siamese/Abyssinian (OSA) kittens (n=43) were weekly compared with Norwegian Forest (NFO) kittens (n=39) from the 4th to the 10th week of age in a repeated Open Field Test (OFT) paradigm. Heart rate (HR) and rectal temperature (RT) before and after the test, and behavioural responses during the OFT were recorded. Behaviours registered were analysed by focal animal sampling. Significant breed differences were found; cats of the northern zones (NFO) seem to develop earlier thermoregulatory abilities. Precocious opening of eyes, higher locomotion scores and longer time spent standing, observed in OSA kittens may indicate an earlier neurological development. Inter breed differences recorded for exploration and locomotion seem to indicate coping style divergences: in the OFT challenging situation OSA kittens presented higher emotional tachycardia and performed more passively, with a faster decline in exploration and locomotion scores. NFO kittens exerted a more active behaviour as they spent more time exploring the arena and in escape attempts. Notwithstanding OSA and NFO cat selection was mainly aimed to improve divergent morphological traits, some different behavioural and physiological traits seem to have been maintained or co-selected within each breed.

  11. Changing doctor prescribing behaviour

    DEFF Research Database (Denmark)

    Gill, P.S.; Mäkelä, M.; Vermeulen, K.M.;

    1999-01-01

    The aim of this overview was to identify interventions that change doctor prescribing behaviour and to derive conclusions for practice and further research. Relevant studies (indicating prescribing as a behaviour change) were located from a database of studies maintained by the Cochrane Collabora......The aim of this overview was to identify interventions that change doctor prescribing behaviour and to derive conclusions for practice and further research. Relevant studies (indicating prescribing as a behaviour change) were located from a database of studies maintained by the Cochrane...... Collaboration on Effective Professional Practice. This register is kept up to date by searching the following databases for reports of relevant research: DHSS-DATA; EMBASE; MEDLINE; SIGLE; Resource Database in Continuing Medical Education (1975-1994), along with bibliographies of related topics, hand searching...

  12. Energy Conservation Behaviour Toolkit

    NARCIS (Netherlands)

    Kalz, Marco; Börner, Dirk; Ternier, Stefaan; Specht, Marcus

    2013-01-01

    Kalz, M., Börner, D., Ternier, S., & Specht, M. (2013, 31 January). Energy Conservation Behaviour Toolkit. Presentation given at the symposium "Groene ICT en Duurzame ontwikkeling: Meters maken in het Hoger Onderwijs", Driebergen, The Netherlands.

  13. Energy efficiency and behaviour

    DEFF Research Database (Denmark)

    Carstensen, Trine Agervig; Kunnasvirta, Annika; Kiviluoto, Katariina

    The purpose of Work Package 5 Deliverable 5.1., “Case study reports on energy efficiency and behaviour” is to present examples of behavioral interventions to promote energy efficiency in cities. The case studies were collected in January – June 2014, and they represent behavioural interventions...... factors. The main addressees of D5.1. are city officials, NGO representatives, private sector actors and any other relevant actors who plan and realize behavioural energy efficiency interventions in European cities. The WP5 team will also further apply results from D5.1. with a more general model on how...... to conduct behavioural interventions, to be presented in Deliverable 5.5., the final report. This report will also provide valuable information for the WP6 general model for an Energy-Smart City. Altogether 38 behavioural interventions are analysed in this report. Each collected and analysed case study...

  14. Long term selection for reduced or increased pecking behaviour in laying hens

    DEFF Research Database (Denmark)

    Buitenhuis, A J; Kjaer, J B

    2008-01-01

    Feather pecking in laying hens is an important issue in animal welfare. Four studies in laying hens were selected which investigated increased or reduced pecking behaviour using direct or indirect measures of feather pecking behaviour. Direct comparison of the selected experiments is difficult...... selection for reduced pecking behaviour changes the immune response. Feather pecking in laying hens is an important issue in animal welfare. Four studies in laying hens were selected which investigated increased or reduced pecking behaviour using direct or indirect measures of feather pecking behaviour...... consensus as to the relation between selection on pecking behaviour and laying performance and egg quality, d) Plasma serotonin level in the blood was reduced in the lines selected against pecking behaviour in both the individual selected lines and the group selected lines and there were indications...

  15. Behaviour and meat quality of Podolian young bulls

    Directory of Open Access Journals (Sweden)

    Fabio Napolitano

    2010-01-01

    Full Text Available From April to August 2008, twelve Podolian subjects, aged about 11 months at the beginning of the experimental period, were used to evaluate the effect of rearing system (Confined vs. Freerange and season (spring vs. summer on their behaviour and meat quality. Nine sessions of behavioural observations were performed. During a 6-h period, the behaviour of a focal animal, was continuously monitored. In each session a different animal was chosen. All the animals were slaughtered at 18 months of age. Walking (P<0.001 and standing (P<0.05 were lower in summer, whereas inactivity was higher (P<0.05. Free-range bulls spent more time walking (P<0.05, feeding (P<0.001 and standing (P<0.01 and showed a lower number of agonistic (P<0.05 and non-agonistic social interaction than confined animals (P<0.01. Self- and allo-grooming were not affected by rearing system, whereas season influenced self-grooming with higher values in spring (P<0.05. Confined animals showed higher final weights (P<0.05 and a lighter meat (P<0.05, whereas no differences between groups were observed for average daily gains, carcass yield, water holding capacity and a* and b* indexes. Confinement markedly affected the behaviour of the animals, whereas free-ranging had only minor negative effects on meat lightness.

  16. Determinants of biosecurity behaviour of British cattle and sheep farmers-a behavioural economics analysis.

    Science.gov (United States)

    Toma, Luiza; Stott, Alistair W; Heffernan, Claire; Ringrose, Siân; Gunn, George J

    2013-03-01

    The paper analyses the impact of a priori determinants of biosecurity behaviour of farmers in Great Britain. We use a dataset collected through a stratified telephone survey of 900 cattle and sheep farmers in Great Britain (400 in England and a further 250 in Wales and Scotland respectively) which took place between 25 March 2010 and 18 June 2010. The survey was stratified by farm type, farm size and region. To test the influence of a priori determinants on biosecurity behaviour we used a behavioural economics method, structural equation modelling (SEM) with observed and latent variables. SEM is a statistical technique for testing and estimating causal relationships amongst variables, some of which may be latent using a combination of statistical data and qualitative causal assumptions. Thirteen latent variables were identified and extracted, expressing the behaviour and the underlying determining factors. The variables were: experience, economic factors, organic certification of farm, membership in a cattle/sheep health scheme, perceived usefulness of biosecurity information sources, knowledge about biosecurity measures, perceived importance of specific biosecurity strategies, perceived effect (on farm business in the past five years) of welfare/health regulation, perceived effect of severe outbreaks of animal diseases, attitudes towards livestock biosecurity, attitudes towards animal welfare, influence on decision to apply biosecurity measures and biosecurity behaviour. The SEM model applied on the Great Britain sample has an adequate fit according to the measures of absolute, incremental and parsimonious fit. The results suggest that farmers' perceived importance of specific biosecurity strategies, organic certification of farm, knowledge about biosecurity measures, attitudes towards animal welfare, perceived usefulness of biosecurity information sources, perceived effect on business during the past five years of severe outbreaks of animal diseases, membership

  17. Velocity dependant splash behaviour

    Science.gov (United States)

    Hamlett, C. A. E.; Shirtcliffe, N. J.; McHale, G.; Ahn, S.; Doerr, S. H.; Bryant, R.; Newton, M. I.

    2012-04-01

    Extreme soil water repellency can occur in nature via condensation of volatile organic compounds released during wildfires and can lead to increased erosion rate. Such extreme water repellent soil can be classified as superhydrophobic and shares similar chemical and topographical features to specifically designed superhydrophobic surfaces. Previous studies using high speed videography to investigate single droplet impact behaviour on artificial superhydrophobic have revealed three distinct modes of splash behaviour (rebound, pinned and fragmentation) which are dependent on the impact velocity of the droplet. In our studies, using high-speed videography, we show that such splash behaviour can be replicated on fixed 'model' water repellent soils (hydrophobic glass beads/particles). We show that the type of splash behaviour is dependent on both the size and chemical nature of the fixed particles. The particle shape also influences the splash behaviour as shown by drop impact experiments on fixed sand samples. We have also studied soil samples, as collected from the field, which shows that the type of droplet splash behaviour can lead to enhanced soil particle transport.

  18. [Animal experimentation, animal welfare and scientific research].

    Science.gov (United States)

    Tal, H

    2013-10-01

    Hundreds of thousands of laboratory animals are being used every year for scientific experiments held in Israel, mostly mice, rats, rabbits, guinea pigs, and a few sheep, cattle, pigs, cats, dogs, and even a few dozen monkeys. In addition to the animals sacrificed to promote scientific research, millions of animals slain every year for other purposes such as meat and fine leather fashion industries. While opening a front against all is an impossible and perhaps an unjustified task, the state of Israel enacted the Animal Welfare (Animal Experimentation) Law (1994). The law aims to regulate scientific animal experiments and to find the appropriate balance between the need to continue to perform animal experiments for the advancement of research and medicine, and at the same time to avoid unnecessary trials and minimize animal suffering. Among other issues the law deals with the phylogenetic scale according to which experimental animals should be selected, experiments for teaching and practicing, and experiments for the cosmetic industry. This article discusses bioethics considerations in animal experiments as well as the criticism on the scientific validity of such experiments. It further deals with the vitality of animal studies and the moral and legal obligation to prevent suffering from laboratory animals.

  19. Cheating and punishment in cooperative animal societies.

    Science.gov (United States)

    Riehl, Christina; Frederickson, Megan E

    2016-02-05

    Cheaters-genotypes that gain a selective advantage by taking the benefits of the social contributions of others while avoiding the costs of cooperating-are thought to pose a major threat to the evolutionary stability of cooperative societies. In order for cheaters to undermine cooperation, cheating must be an adaptive strategy: cheaters must have higher fitness than cooperators, and their behaviour must reduce the fitness of their cooperative partners. It is frequently suggested that cheating is not adaptive because cooperators have evolved mechanisms to punish these behaviours, thereby reducing the fitness of selfish individuals. However, a simpler hypothesis is that such societies arise precisely because cooperative strategies have been favoured over selfish ones-hence, behaviours that have been interpreted as 'cheating' may not actually result in increased fitness, even when they go unpunished. Here, we review the empirical evidence for cheating behaviours in animal societies, including cooperatively breeding vertebrates and social insects, and we ask whether such behaviours are primarily limited by punishment. Our review suggests that both cheating and punishment are probably rarer than often supposed. Uncooperative individuals typically have lower, not higher, fitness than cooperators; and when evidence suggests that cheating may be adaptive, it is often limited by frequency-dependent selection rather than by punishment. When apparently punitive behaviours do occur, it remains an open question whether they evolved in order to limit cheating, or whether they arose before the evolution of cooperation.

  20. Effect of neglecting geothermal gradient on calculated oil recovery

    Science.gov (United States)

    Safari, Mehdi; Mohammadi, Majid; Sedighi, Mehdi

    2017-03-01

    Reduced recovery rate with time is a common challenge for most of the oil producing reservoirs. Water flooding is one of the most common methods used for enhanced oil recovery. Simulating water-flooding process is sometimes carried out without considering the effect of geothermal gradient, and an average temperature is assumed for all the grid blocks. However, the gradient plays a significant role on the reservoir fluid properties. So neglecting its effect might result in a large error in the calculated oil recovery results, especially for the thick reservoirs, which in theory can show significant variations in temperature with depth. In this paper, first, advancing the waterfront during injection into a geothermal oil reservoir is discussed. Then, the performance of considering either an average temperature or gradient temperature, are considered and compared with each other. The results suggest that assuming a fixed average reservoir temperature with no geothermal gradient, can lead to a pronounced error for calculated oil recovery.

  1. Neglected parasitic infections in the United States: trichomoniasis.

    Science.gov (United States)

    Secor, W Evan; Meites, Elissa; Starr, Michelle C; Workowski, Kimberly A

    2014-05-01

    Trichomonas vaginalis is one of the most common human parasitic infections in the United States, as well as the most prevalent non-viral sexually transmitted infection. However, it has long received much less consideration than other parasitic and sexually transmitted diseases. Much of this inattention can be attributed to a poor understanding of the public health impact of trichomoniasis. Increasing recognition of the sequelae of infection, including increased risk of infection with human immunodeficiency virus and adverse outcomes of pregnancy, has led to increased interest in T. vaginalis. Recent innovations include development of diagnostic tests that could improve detection of the parasite. A number of important questions, such as the epidemiology among men and women, the true public health burden of symptomatic and asymptomatic T. vaginalis infections, and whether current treatments will be adequate to reduce the substantial health disparities and costs associated with trichomoniasis, need consideration to remedy neglect of this important disease.

  2. Artificial bias typically neglected in comparisons of uncertain atmospheric data

    Science.gov (United States)

    Pitkänen, Mikko R. A.; Mikkonen, Santtu; Lehtinen, Kari E. J.; Lipponen, Antti; Arola, Antti

    2016-09-01

    Publications in atmospheric sciences typically neglect biases caused by regression dilution (bias of the ordinary least squares line fitting) and regression to the mean (RTM) in comparisons of uncertain data. We use synthetic observations mimicking real atmospheric data to demonstrate how the biases arise from random data uncertainties of measurements, model output, or satellite retrieval products. Further, we provide examples of typical methods of data comparisons that have a tendency to pronounce the biases. The results show, that data uncertainties can significantly bias data comparisons due to regression dilution and RTM, a fact that is known in statistics but disregarded in atmospheric sciences. Thus, we argue that often these biases are widely regarded as measurement or modeling errors, for instance, while they in fact are artificial. It is essential that atmospheric and geoscience communities become aware of and consider these features in research.

  3. The untapped cell biology of neglected tropical diseases

    Science.gov (United States)

    Sullivan, William

    2016-01-01

    The World Health Organization lists a constellation of 17 tropical diseases that afflict approximately one in six individuals on the planet and, until recently, few resources have been devoted to the treatment and eradication of those diseases. They are often referred to as the diseases of the “bottom billion,” because they are most prevalent among the poorest individuals in impoverished tropical nations. However, the few studies that have been performed reveal an extraordinary world of molecular and cellular adaptations that facilitate the pathogens’ survival in hosts ranging from insects to humans. A compelling case can be made that even a modest investment toward understanding the basic molecular and cell biology of these neglected pathogens has a high probability of yielding exciting new cellular mechanisms and insights into novel ways of combating these diseases. PMID:26915691

  4. Ebola and Marburg hemorrhagic fevers: neglected tropical diseases?

    Directory of Open Access Journals (Sweden)

    Adam MacNeil

    2012-06-01

    Full Text Available Ebola hemorrhagic fever (EHF and Marburg hemorrhagic fever (MHF are rare viral diseases, endemic to central Africa. The overall burden of EHF and MHF is small in comparison to the more common protozoan, helminth, and bacterial diseases typically referred to as neglected tropical diseases (NTDs. However, EHF and MHF outbreaks typically occur in resource-limited settings, and many aspects of these outbreaks are a direct consequence of impoverished conditions. We will discuss aspects of EHF and MHF disease, in comparison to the "classic" NTDs, and examine potential ways forward in the prevention and control of EHF and MHF in sub-Saharan Africa, as well as examine the potential for application of novel vaccines or antiviral drugs for prevention or control of EHF and MHF among populations at highest risk for disease.

  5. Neglecting Primordial non-Gaussianity Threatens Future Cosmological Experiment Accuracy

    CERN Document Server

    Camera, Stefano; Fedeli, Cosimo; Moscardini, Lauro

    2014-01-01

    Future galaxy redshift surveys aim at probing the clustering of the cosmic large-scale structure with unprecedented accuracy, thus complementing cosmic microwave background experiments in the quest of delivering the most precise and accurate picture ever of our Universe. Analyses of such measurements are usually performed within the context of the so-called vanilla LCDM model - the six-parameter phenomenological model which, for instance, emerges from best fits against the recent data obtained by the Planck satellite. Here, we show that such an approach is prone to subtle systematics when the Gaussianity of primordial fluctuations is concerned. In particular, we demonstrate that, if we neglect even a tiny amount of primordial non-Gaussianity - fully consistent with current limits - we shall introduce spurious biases in the reconstruction of cosmological parameters. This is a serious issue that must be properly accounted for in the view of accurate - besides precise - cosmology.

  6. Eliminating the Neglected Tropical Diseases: Translational Science and New Technologies.

    Directory of Open Access Journals (Sweden)

    Peter J Hotez

    2016-03-01

    Full Text Available Today, the World Health Organization recognizes 17 major parasitic and related infections as the neglected tropical diseases (NTDs. Despite recent gains in the understanding of the nature and prevalence of NTDs, as well as successes in recent scaled-up preventive chemotherapy strategies and other health interventions, the NTDs continue to rank among the world's greatest global health problems. For virtually all of the NTDs (including those slated for elimination under the auspices of a 2012 London Declaration for NTDs and a 2013 World Health Assembly resolution [WHA 66.12], additional control mechanisms and tools are needed, including new NTD drugs, vaccines, diagnostics, and vector control agents and strategies. Elimination will not be possible without these new tools. Here we summarize some of the key challenges in translational science to develop and introduce these new technologies in order to ensure success in global NTD elimination efforts.

  7. Unplugging the Universe: the neglected electromagnetic consequence of decoupling

    CERN Document Server

    Diver, Declan A

    2007-01-01

    This letter concentrates on the non-equilibrium evolution of magnetic field structures at the onset of recombination, when the charged particle current densities decay as neutrals are formed. We consider the effect that a decaying magnetic flux has on the acceleration of particles via the transient induced electric field. Since the residual charged-particle number density is small as a result of decoupling, we shall consider the magnetic and electric fields essentially to be imposed, neglecting the feedback from any minority accelerated population. We find that the electromagnetic treatment of this phase transition can produce energetic electrons scattered throughout the Universe. Such particles could have a significant effect on cosmic evolution in several ways: (i) their presence could delay the effective end of the recombination era; (ii) they could give rise to plasma concentrations that could enhance early gravitational collapse of matter by opposing cosmic expansion to a greater degree than neutral matt...

  8. Neglected organization and management issues in mental health systems development.

    Science.gov (United States)

    Greenley, J R

    1992-10-01

    Fragmented and often uncoordinated public services for the more severely mentally ill are often characteristic of the current U.S. mental health system. The creation of local mental health authorities has been promoted as part of a solution, as has happened in Wisconsin at the county level and is championed in the ongoing Robert Wood Johnson Foundation funded innovative service sites for severely mentally ill adults. There are indications that these innovative mental health authorities will fall short of fulfilling their promise. Basic principles from the management and organizations literature are used to identify several organization and management issues that may have been neglected. These include resource management, attention to system goals, monitoring and feedback, and the promotion of desirable interorganizational cultures.

  9. Ebola outbreak in West Africa: a neglected tropical disease

    Institute of Scientific and Technical Information of China (English)

    Alcides; Troncoso

    2015-01-01

    Neglected tropical diseases(NTDs) are remediable injustices of our times. Poverty is the starting point, and the ultimate outcome, of NTD. Ebola is just one of many NTDs that badly need attention. Ebola exacerbates West Africa’s poverty crisis. The virus spreading in Guinea,Liberia and Sierra Leone has led to food shortages and neglect of other devastating tropical illnesses. A health crisis that was ignored for months until it was out of control is now beginning to get the attention required, if not the resources. So far, the world′s nations have contributed far less than the $ 1 billion. The U.N. estimates would need to control the epidemic before it becomes endemic. Past outbreaks of Ebola have flared up in remote, forested communities, disconnected from much of the outside world. But the outbreak in West Africa has not slowed yet, and it worsens there the chances of it spreading to other countries. Ebola draws attention to NTD. Ebola is not only a health emergency, but also it′s a poverty crisis.The current Global Ebola crisis presents a multitude of challenges in terms of our capacity to respond; the future is even less predictable. Ebola outbreak represents inequity in health as the occurrence of health differences considered unnecessary, avoidable, unfair, and unjust, thus adding a moral and ethical dimension to health inequalities. Health equity does not refer only to the fairness in the distribution of health or the provision of health care; rather, it is linked with the larger issues of fairness and justice in social arrangements.

  10. Surgical treatment of neglected clubfoot using external fixator

    Directory of Open Access Journals (Sweden)

    Rodrigo Mota Pacheco Fernandes

    Full Text Available ABSTRACT The definition of neglected clubfoot (NC includes a variable range of complex deformities of the foot that are refractory to conventional treatments or are treated inappropriately. Several etiologies may be related to this. The Ilizarov method has become established as a tool for treating these deformities. It minimizes soft-tissue damage through gradual correction of the deformity, with a high success rate in relation to achieving a plantigrade foot, with low incidence of recurrence. The indications for treatment include severe rigid deformities (Dimeglio III and IV, or adverse skin conditions. Careful clinical and radiological examination is fundamental for proper planning and installation of the external fixator. The techniques used include selection of external fixation assemblies, which can be closed when there is a connection between the leg, hindfoot and forefoot. This closed assembly may or may not be constricted, according to whether hinges are provided or whether use of the natural anatomical hinges during correction of the deformity is envisaged. An open assembly makes it possible to add flexibility to the foot through histogenesis, while allowing closed corrections of greater precision later on. Hexapod fixators are an innovation with high potential for accuracy in correcting deformities. Procedures associated with external fixation include soft-tissue release and bone procedures. These procedures enable corrections that are more anatomical, for different degrees of severity and stiffness of deformity. It can be concluded from analyzing this case series that treatment of neglected clubfoot using an external fixator has a high rate of good and excellent results, with low frequency of complications.

  11. Ebola outbreak in West Africa: a neglected tropical disease

    Directory of Open Access Journals (Sweden)

    Alcides Troncoso

    2015-04-01

    Full Text Available Neglected tropical diseases (NTDs are remediable injustices of our times. Poverty is the starting point, and the ultimate outcome, of NTD. Ebola is just one of many NTDs that badly need attention. Ebola exacerbates West Africa's poverty crisis. The virus spreading in Guinea, Liberia and Sierra Leone has led to food shortages and neglect of other devastating tropical illnesses. A health crisis that was ignored for months until it was out of control is now beginning to get the attention required, if not the resources. So far, the world´s nations have contributed far less than the $ 1 billion. The U.N. estimates would need to control the epidemic before it becomes endemic. Past outbreaks of Ebola have flared up in remote, forested communities, disconnected from much of the outside world. But the outbreak in West Africa has not slowed yet, and it worsens there the chances of it spreading to other countries. Ebola draws attention to NTD. Ebola is not only a health emergency, but also it´s a poverty crisis. The current Global Ebola crisis presents a multitude of challenges in terms of our capacity to respond; the future is even less predictable. Ebola outbreak represents inequity in health as the occurrence of health differences considered unnecessary, avoidable, unfair, and unjust, thus adding a moral and ethical dimension to health inequalities. Health equity does not refer only to the fairness in the distribution of health or the provision of health care; rather, it is linked with the larger issues of fairness and justice in social arrangements.

  12. Between and Animals

    Institute of Scientific and Technical Information of China (English)

    1994-01-01

    Animals are man’s best friends. Animals remind man of his own infancy. People and animals get on well with each other, so the world is bright and colorful. Animals are children’s close pals, too. Being on intimate terms with animals makes children more kind-hearted and sympathetic.

  13. Eusocial insects as emerging models for behavioural epigenetics.

    Science.gov (United States)

    Yan, Hua; Simola, Daniel F; Bonasio, Roberto; Liebig, Jürgen; Berger, Shelley L; Reinberg, Danny

    2014-10-01

    Understanding the molecular basis of how behavioural states are established, maintained and altered by environmental cues is an area of considerable and growing interest. Epigenetic processes, including methylation of DNA and post-translational modification of histones, dynamically modulate activity-dependent gene expression in neurons and can therefore have important regulatory roles in shaping behavioural responses to environmental cues. Several eusocial insect species - with their unique displays of behavioural plasticity due to age, morphology and social context - have emerged as models to investigate the genetic and epigenetic underpinnings of animal social behaviour. This Review summarizes recent studies in the epigenetics of social behaviour and offers perspectives on emerging trends and prospects for establishing genetic tools in eusocial insects.

  14. Humpback Dolphin (Genus Sousa) Behavioural Responses to Human Activities.

    Science.gov (United States)

    Piwetz, Sarah; Lundquist, David; Würsig, Bernd

    2015-01-01

    Humpback dolphins (genus Sousa) use shallow, near-shore waters throughout their range. This coastal distribution makes them vulnerable to recreational and commercial disturbances, especially near heavily populated and industrialized areas. Most research focusing on Sousa and human activities has emphasized direct impacts and threats, involving injury and death, with relatively little focus on indirect effects on dolphins, such as changes in behaviour that may lead to deleterious effects. Understanding behaviour is important in resolving human-wildlife conflict and is an important component of conservation. This chapter gives an overview of animal behavioural responses to human activity with examples from diverse taxa; reviews the scientific literature on behavioural responses of humpback dolphins to human activity throughout their range, including marine vessel traffic, dolphin tourism, cetacean-fishery interactions, noise pollution, and habitat alteration; and highlights information and data gaps for future humpback dolphin research to better inform behaviour-based management decisions that contribute to conservation efforts.

  15. Deployment Family Stress: Child Neglect and Maltreatment in U.S. Army Families

    Science.gov (United States)

    2013-10-01

    08-2-0189 TITLE: Deployment Family Stress: Child Neglect and Maltreatment in U.S. Army Families PRINCIPAL INVESTIGATOR: Stephen...10      4 | P a g e INTRODUCTION The Deployment Family Stress: Child Neglect and Maltreatment in the U.S. Army study...was conducted to identify the effects of child neglect within and around military installations. Data for this study was collected from clinical

  16. Patient neglect in healthcare institutions: a systematic review and conceptual model

    OpenAIRE

    Reader, Tom W; Gillespie, Alex

    2013-01-01

    Background\\ud Patient neglect is an issue of increasing public concern in Europe and North America, yet remains poorly understood. This is the first systematic review on the nature, frequency and causes of patient neglect as distinct from patient safety topics such as medical error.\\ud \\ud Method\\ud The Pubmed, Science Direct, and Medline databases were searched in order to identify research studies investigating patient neglect. Ten articles and four government reports met the inclusion crit...

  17. Do race, neglect, and childhood poverty predict physical health in adulthood? A multilevel prospective analysis

    OpenAIRE

    Nikulina, Valentina

    2013-01-01

    Childhood neglect and poverty often co-occur and both have been linked to poor physical health outcomes. In addition, Blacks have higher rates of childhood poverty and tend to have worse health than Whites. This paper examines the unique and interacting effects of childhood neglect, race, and family and neighborhood poverty on adult physical health outcomes. This prospective cohort design study uses a sample (N = 675) of court-substantiated cases of childhood neglect and matched controls foll...

  18. How does agonistic behaviour differ in albino and pigmented fish?

    Directory of Open Access Journals (Sweden)

    Ondřej Slavík

    2016-04-01

    Full Text Available In addition to hypopigmentation of the skin and red iris colouration, albino animals also display distinct physiological and behavioural alterations. However, information on the social interactions of albino animals is rare and has mostly been limited to specially bred strains of albino rodents and animals from unique environments in caves. Differentiating between the effects of albinism and domestication on behaviour in rodents can be difficult, and social behaviour in cave fish changes according to species-specific adaptations to conditions of permanent darkness. The agonistic behaviours of albino offspring of pigmented parents have yet to be described. In this study, we observed agonistic behaviour in albino and pigmented juvenile Silurus glanis catfish. We found that the total number of aggressive interactions was lower in albinos than in pigmented catfish. The distance between conspecifics was also analysed, and albinos showed a tendency towards greater separation from their same-coloured conspecifics compared with pigmented catfish. These results demonstrate that albinism can be associated with lower aggressiveness and with reduced shoaling behaviour preference, as demonstrated by a tendency towards greater separation of albinos from conspecifics.

  19. How does agonistic behaviour differ in albino and pigmented fish?

    Science.gov (United States)

    Slavík, Ondřej; Horký, Pavel; Wackermannová, Marie

    2016-01-01

    In addition to hypopigmentation of the skin and red iris colouration, albino animals also display distinct physiological and behavioural alterations. However, information on the social interactions of albino animals is rare and has mostly been limited to specially bred strains of albino rodents and animals from unique environments in caves. Differentiating between the effects of albinism and domestication on behaviour in rodents can be difficult, and social behaviour in cave fish changes according to species-specific adaptations to conditions of permanent darkness. The agonistic behaviours of albino offspring of pigmented parents have yet to be described. In this study, we observed agonistic behaviour in albino and pigmented juvenile Silurus glanis catfish. We found that the total number of aggressive interactions was lower in albinos than in pigmented catfish. The distance between conspecifics was also analysed, and albinos showed a tendency towards greater separation from their same-coloured conspecifics compared with pigmented catfish. These results demonstrate that albinism can be associated with lower aggressiveness and with reduced shoaling behaviour preference, as demonstrated by a tendency towards greater separation of albinos from conspecifics.

  20. Long-Term Efficacy of Prism Adaptation on Spatial Neglect: Preliminary Results on Different Spatial Components

    Directory of Open Access Journals (Sweden)

    Maria Luisa Rusconi

    2012-01-01

    Full Text Available This study describes the long-term effectiveness on spatial neglect recovery of a 2-week treatment based on prism adaptation (PA. Seven right-brain-damaged patients affected by chronic neglect were evaluated before, after two weeks of the PA treatment and at a follow-up (variable between 8 and 30 months after the end of PA. Neglect evaluation was performed by means of BIT (conventional and behavioral, Fluff Test, and Comb and Razor Test. The results highlight an improvement, after the PA training, in both tasks performed using the hand trained in PA treatment and in behavioral tasks not requiring a manual motor response. Such effects extend, even if not significantly, to all BIT subtests. These results support previous findings, showing that PA improves neglect also on imagery tasks with no manual component, and provide further evidence for long-lasting efficacy of PA training. Dissociations have been found with regard to PA efficacy on peripersonal, personal, and representational neglect, visuospatial agraphia and neglect dyslexia. In particular, we found no significant differences between the pre-training and post-training PA session in personal neglect measures, and a poor recovery of neglect dyslexia after PA treatment. The recruitment of a larger sample could help to confirm the effectiveness of the prismatic lenses with regard to the different clinical manifestations of spatial neglect.