WorldWideScience

Sample records for angle of rest

  1. The Achilles tendon resting angle as an indirect measure of Achilles tendon length following rupture, repair, and rehabilitation

    Directory of Open Access Journals (Sweden)

    Michael R. Carmont

    2015-04-01

    Conclusion: The ATRA increases following injury, is reduced by surgery, and then increases again during initial rehabilitation. The angle also correlates with patient-reported symptoms early in the rehabilitation phase and with heel-rise height after 1 year. The ATRA might be considered a simple and effective means to evaluate Achilles tendon function 1 year after the rupture.

  2. Estimating Long GRB Jet Opening Angles and Rest-Frame Energetics

    Science.gov (United States)

    Goldstein, Adam; Connaughton, Valerie; Briggs, Michael Stephen; Burns, Eric

    2016-04-01

    We present a method to estimate the jet opening angles of long duration Gamma-Ray Bursts (GRBs) using the prompt gamma-ray energetics and a correlation between the time-integrated peak energy of the GRB prompt spectrum and the collimation-corrected energy in gamma rays. The derived jet opening angles using this method match well with the corresponding inferred jet opening angles obtained when a break in the afterglow is observed. Furthermore, using a model of the predicted long GRB redshift probability distribution observable by the Fermi Gamma-ray Burst Monitor (GBM), we estimate the probability distributions for the jet opening angle and rest-frame energetics for a large sample of GBM GRBs for which the redshifts have not been observed. Previous studies have only used a handful of GRBs to estimate these properties due to the paucity of observed afterglow jet breaks, spectroscopic redshifts, and comprehensive prompt gamma-ray observations, and we expand the number of GRBs that can be used in this analysis by more than an order of magnitude. In this analysis, we also present an inferred distribution of jet breaks which indicates that a large fraction of jet breaks are not observable with current instrumentation and observing strategies. We present simple parameterizations for the jet angle, energetics, and jet break distributions so that they may be used in future studies.

  3. Estimating Long GRB Jet Opening Angles and Rest-Frame Energetics

    Science.gov (United States)

    Goldstein, Adam; Connaughton, Valerie; Briggs, Michael; Burns, Eric

    2016-03-01

    We present a method to estimate the jet opening angles of long Gamma-Ray Bursts (GRBs) using the prompt gamma-ray energetics and a correlation between the time-integrated peak energy of the GRB prompt spectrum and the collimation-corrected energy in gamma rays. The derived jet opening angles using this method match well with the corresponding inferred jet opening angles obtained when a break in the afterglow is observed. Furthermore, using a model of the predicted long GRB redshift probability distribution observable by the Fermi Gamma-ray Burst Monitor (GBM), we estimate the probability distributions for the jet opening angle and rest-frame energetics for a large sample of GBM GRBs for which the redshifts have not been observed. Previous studies have only used a handful of GRBs to estimate these properties due to the paucity of observed afterglow jet breaks, spectroscopic redshifts, and comprehensive prompt gamma-ray observations, and we expand the number of GRBs that can be used in this analysis by more than an order of magnitude. We also present an inferred distribution of jet breaks which indicates that a large fraction of jet breaks are not observable with current instrumentation and observing strategies. A.G. is funded by the NASA Postdoctoral Program through USRA.

  4. Estimating Long GRB Jet Opening Angles and Rest-Frame Energetics

    CERN Document Server

    Goldstein, Adam; Briggs, Michael S; Burns, Eric

    2015-01-01

    We present a method to estimate the jet opening angles of long duration Gamma-Ray Bursts (GRBs) using the prompt gamma-ray energetics and an inversion of the Ghirlanda relation, which is a correlation between the time-integrated peak energy of the GRB prompt spectrum and the collimation-corrected energy in gamma rays. The derived jet opening angles using this method and detailed assumptions match well with the corresponding inferred jet opening angles obtained when a break in the afterglow is observed. Furthermore, using a model of the predicted long GRB redshift probability distribution observable by the Fermi Gamma-ray Burst Monitor (GBM), we estimate the probability distributions for the jet opening angle and rest-frame energetics for a large sample of GBM GRBs for which the redshifts have not been observed. Previous studies have only used a handful of GRBs to estimate these properties due to the paucity of observed afterglow jet breaks, spectroscopic redshifts, and comprehensive prompt gamma-ray observati...

  5. A kinematic comparison of alterations to knee and ankle angles from resting measures to active pedaling during a graded exercise protocol.

    Science.gov (United States)

    Peveler, Willard W; Shew, Brandy; Johnson, Samantha; Palmer, Thomas G

    2012-11-01

    Saddle height is one of the most researched areas of bike fit. The current accepted method for adjusting saddle height involves the use of a goniometer to adjust saddle height so that a knee angle between 25° and 35° is obtained. This measurement is taken while the cyclist maintains a static position with the pedal at the 6-o'-clock position. However, the act of pedaling is dynamic, and angles may alter during movement. The purpose of this study was to examine the alterations to knee and ankle angle occurring from static measures to active pedaling across intensities experienced by cyclists during a graded exercise protocol. Thirty-four recreational to highly trained cyclists were evaluated using 2D analysis of stationary position and 3 active levels (level 1, respiratory exchange ratio of 1.00, and max). Dependent measures were compared using repeated measures analysis of variance (p = 0.05). When examining the results, it is evident that significant alterations to pedal stroke occur from stationary measures to active pedaling and as intensity increases toward maximal. Plantar flexion increased when moving from stationary measures to active pedaling, which resulted in an increase in knee angle. Although still greater than stationary measures, less plantar flexion occurred at higher intensities when compared with lower intensity cycling. Less plantar flexion at higher intensities is most likely a result of application of a larger downward torque occurring because of greater power requirements at higher intensities. There appeared to be greater variability in angle when examining novice cyclists in relation to more experienced cyclists. Although stationary measures are where a bike fit session will begin, observation during the pedal cycle may be needed to fine-tune the riders' fit. PMID:22158094

  6. Physiology Of Prolonged Bed Rest

    Science.gov (United States)

    Greenleaf, John E.

    1991-01-01

    Report describes physiological effects of prolonged bed rest. Rest for periods of 24 hours or longer deconditions body to some extent; healing proceeds simultaneously with deconditioning. Report provides details on shifts in fluid electrolytes and loss of lean body mass, which comprises everything in body besides fat - that is, water, muscle, and bone. Based on published research.

  7. Clinical physiology of bed rest

    Science.gov (United States)

    Greenleaf, John E.

    1993-01-01

    Maintenance of optimal health in humans requires the proper balance between exercise, rest, and sleep as well as time in the upright position. About one-third of a lifetime is spent sleeping; and it is no coincidence that sleeping is performed in the horizontal position, the position in which gravitational influence on the body is minimal. Although enforced bed rest is necessary for the treatment of some ailments, in some cases it has probably been used unwisely. In addition to the lower hydrostatic pressure with the normally dependent regions of the cardiovascular system, body fuid compartments during bed rest in the horizontal body position, and virtual elimination of compression on the long bones of the skeletal system during bed rest (hypogravia), there is often reduction in energy metabolism due to the relative confinement (hypodynamia) and alteration of ambulatory circadian variations in metabolism, body temperature, and many hormonal systems. If patients are also moved to unfamiliar surroundings, they probably experience some feelings of anxiety and some sociopsychological problems. Adaptive physiological responses during bed rest are normal for that environment. They are attempts by the body to reduce unnecessary energy expenditure, to optimize its function, and to enhance its survival potential. Many of the deconditioning responses begin within the first day or two of bed rest; these early responses have prompted physicians to insist upon early resumption of the upright posture and ambulation of bedridden patients.

  8. Clustering of resting state networks.

    Directory of Open Access Journals (Sweden)

    Megan H Lee

    Full Text Available BACKGROUND: The goal of the study was to demonstrate a hierarchical structure of resting state activity in the healthy brain using a data-driven clustering algorithm. METHODOLOGY/PRINCIPAL FINDINGS: The fuzzy-c-means clustering algorithm was applied to resting state fMRI data in cortical and subcortical gray matter from two groups acquired separately, one of 17 healthy individuals and the second of 21 healthy individuals. Different numbers of clusters and different starting conditions were used. A cluster dispersion measure determined the optimal numbers of clusters. An inner product metric provided a measure of similarity between different clusters. The two cluster result found the task-negative and task-positive systems. The cluster dispersion measure was minimized with seven and eleven clusters. Each of the clusters in the seven and eleven cluster result was associated with either the task-negative or task-positive system. Applying the algorithm to find seven clusters recovered previously described resting state networks, including the default mode network, frontoparietal control network, ventral and dorsal attention networks, somatomotor, visual, and language networks. The language and ventral attention networks had significant subcortical involvement. This parcellation was consistently found in a large majority of algorithm runs under different conditions and was robust to different methods of initialization. CONCLUSIONS/SIGNIFICANCE: The clustering of resting state activity using different optimal numbers of clusters identified resting state networks comparable to previously obtained results. This work reinforces the observation that resting state networks are hierarchically organized.

  9. Perception of perspective angles

    NARCIS (Netherlands)

    Erkelens, C.J.

    2015-01-01

    We perceive perspective angles, that is, angles that have an orientation in depth, differently from what they are in physical space. Extreme examples are angles between rails of a railway line or between lane dividers of a long and straight road. In this study, subjects judged perspective angles bet

  10. Rest frame of bubble nucleation

    Energy Technology Data Exchange (ETDEWEB)

    Garriga, Jaume [Departament de Física Fondamental i Institut de Ciencies del Cosmos, Universitat de Barcelona, Martí i Franquès 1, 08028 Barcelona (Spain); Kanno, Sugumi [Institute of Cosmology, Department of Physics and Astronomy, Tufts University, Medford, Massachusetts 02155 (United States); Tanaka, Takahiro, E-mail: jaume.garriga@ub.edu, E-mail: sugumi@cosmos.phy.tufts.edu, E-mail: tanaka@yukawa.kyoto-u.ac.jp [Yukawa Institute for Theoretical Physics, Kyoto University, Kyoto 606-8502 (Japan)

    2013-06-01

    Vacuum bubbles nucleate at rest with a certain critical size and subsequently expand. But what selects the rest frame of nucleation? This question has been recently addressed in [1] in the context of Schwinger pair production in 1+1 dimensions, by using a model detector in order to probe the nucleated pairs. The analysis in [1] showed that, for a constant external electric field, the adiabatic ''in'' vacuum of charged particles is Lorentz invariant, (and in this) case pairs tend to nucleate preferentially at rest with respect to the detector. Here, we sharpen this picture by showing that the typical relative velocity between the frame of nucleation and that of the detector is at most of order Δv ∼ S{sub E}{sup −1/3} << 1. Here, S{sub E} >> 1 is the action of the instanton describing pair creation. The bound Δv coincides with the minimum uncertainty in the velocity of a non-relativistic charged particle embedded in a constant electric field. A velocity of order Δv is reached after a time interval of order Δt ∼ S{sub E}{sup −1/3}r{sub 0} << r{sub 0} past the turning point in the semiclassical trajectory, where r{sub 0} is the size of the instanton. If the interaction takes place in the vicinity of the turning point, the semiclassical description of collision does not apply. Nonetheless, we find that even in this case there is still a strong asymmetry in the momentum transferred from the nucleated particles to the detector, in the direction of expansion after the turning point. We conclude that the correlation between the rest frame of nucleation and that of the detector is exceedingly sharp.

  11. Rest requirements and rest management of personnel in shift work

    Energy Technology Data Exchange (ETDEWEB)

    Hammell, B.D. [PDG Environmental, Melbourne, FL (United States); Scheuerle, A. [Univ. of Texas, Houston, TX (United States)

    1995-12-31

    A difficulty-weighted shift assignment scheme is proposed for use in prolonged and strenuous field operations such as emergency response, site testing, and short term hazardous waste remediation projects. The purpose of the work rotation plan is to increase productivity, safety, and moral of workers. Job weighting is accomplished by assigning adjustments to the mental and physical intensity of the task, the protective equipment worn, and the climatic conditions. The plan is based on medical studies of sleep deprivation, the effects of rest adjustments, and programs to reduce sleep deprivation and normalize shift schedules.

  12. The Resting Brain of Alcoholics.

    Science.gov (United States)

    Müller-Oehring, Eva M; Jung, Young-Chul; Pfefferbaum, Adolf; Sullivan, Edith V; Schulte, Tilman

    2015-11-01

    Chronic alcohol consumption affects multiple cognitive processes supported by far-reaching cerebral networks. To identify neurofunctional mechanisms underlying selective deficits, 27 sober alcoholics and 26 age-matched controls underwent resting-state functional magnetic resonance imaging and neuropsychological testing. Functional connectivity analysis assessed the default mode network (DMN); integrative executive control (EC), salience (SA), and attention (AT) networks; primary somatosensory, auditory, and visual (VI) input networks; and subcortical reward (RW) and emotion (EM) networks. The groups showed an extensive overlap of intrinsic connectivity in all brain networks examined, suggesting overall integrity of large-scale functional networks. Despite these similar patterns, connectivity analyses identified network-specific differences of weaker within-network connectivity and expanded connectivity to regions outside the main networks in alcoholics compared with controls. For AT and VI networks, better task performance was related to expanded connectivity in alcoholism, supporting the concept of network expansion as a neural mechanism for functional compensation. For default mode, SA, RW, and EC networks, both weaker within-network and expanded outside-network connectivity correlated with poorer performance and mood. Current smoking contributed to some of these abnormalities in connectivity. The observed pattern of resting-state connectivity might reflect neural vulnerability of intrinsic networking in alcoholics and suggests a mechanism to explain signature impairments in EM, RW evaluation, and EC ability. PMID:24935777

  13. Resting state EEG correlates of memory consolidation.

    Science.gov (United States)

    Brokaw, Kate; Tishler, Ward; Manceor, Stephanie; Hamilton, Kelly; Gaulden, Andrew; Parr, Elaine; Wamsley, Erin J

    2016-04-01

    Numerous studies demonstrate that post-training sleep benefits human memory. At the same time, emerging data suggest that other resting states may similarly facilitate consolidation. In order to identify the conditions under which non-sleep resting states benefit memory, we conducted an EEG (electroencephalographic) study of verbal memory retention across 15min of eyes-closed rest. Participants (n=26) listened to a short story and then either rested with their eyes closed, or else completed a distractor task for 15min. A delayed recall test was administered immediately following the rest period. We found, first, that quiet rest enhanced memory for the short story. Improved memory was associated with a particular EEG signature of increased slow oscillatory activity (communication. Our findings suggest that EEG slow oscillations could play a significant role in memory consolidation during other resting states as well. PMID:26802698

  14. The Physiology of Bed Rest. Chapter 39

    Science.gov (United States)

    Fortney, Suzanne M.; Schneider, Victor S.; Greenleaf, John E.

    1996-01-01

    Prolonged rest in bed has been utilized by physicians and other health-care workers to immobilize and confine patients for rehabilitation and restoration of health since time immemorial. The sitting or horizontal position is sought by the body to relieve the strain of the upright or vertical postures, for example during syncopal situations, bone fractures, muscle injuries, fatigue, and probably also to reduce energy expenditure. Most health-care personnel are aware that adaptive responses occurring during bed rest proceed concomitantly with the healing process; signs and symptoms associated with the former should be differentiated from those of the latter. Not all illnesses and infirmities benefit from prolonged bed rest. Considerations in prescribing bed rest for patients-including duration, body position, mode and duration of exercise, light-dark cycles, temperature, and humidity-have not been investigated adequately. More recently, adaptive physiological responses have been measured in normal, healthy subjects in the horizontal or slightly head-down postures during prolonged bed rest as analogs for the adaptive responses of astronauts exposed to the microgravity environment of outer and bed-rest research.

  15. MR imaging features of adrenal rest tumor

    International Nuclear Information System (INIS)

    Objective: To investigate the imaging features of adrenal rest tumor. Methods: Twelve patients of adrenal rest tumor proved by surgery or clinical diagnosis were retrospectively analyzed. Among these 12 patients, 12 were examined with ultrasound, 11 with MR and 1 with CT. MR and CT were performed without and with intravenous injection of contrast material. The imaging features of adrenal rest tumor were retrospectively summarized and the relevant literatures reviewed. Results: The adrenal rest tumors were found in testis in 10 of the 12 patients, and in ovaries and broad ligament in the remaining two. The imaging features of the testicular adrenal rest tumor were summarized as following: all patients had bilateral testicular masses without change of the testicular contour. On ultrasonography, the lesions were hypoechoic, with some hyperechoic areas and appeared highly vascularized on Colour Doppler ultrasonography. The masses showed iso-density on plain CT, and avid enhancement on post-contrast CT images. The masses ranging in size from 0.7 cm×1.0 cm×2.2 cm to 2.3 cm ×2.7 cm ×2.9 cm with uniform signal intensity, lobulated margin on MRI. They exhibited iso- or slight hyperintensity on T1WI and hypointensity on T2WI relative to normal testicular parenchyma. The tumors showed intense enhancement on post-contrast MR images. No abnormality was detected with Colour Doppler ultrasonography and MR in 2 patients of adrenal rest tumor in ovaries and broad ligament. Conclusion: Combining imaging features with the typical clinical history,the diagnosis of adrenal rest tumor could be suggested pre-operatively. (authors)

  16. Effects Of Exercise During Prolonged Bed Rest

    Science.gov (United States)

    Arnaud, S.; Berry, P; Cohen, M.; Danelis, J.; Deroshia, C.; Greenleaf, J.; Harris, B.; Keil, L.; Bernauer, E.; Bond, M.; Ellis, S.; Lee, P.; Selzer, R.; Wade, C.

    1992-01-01

    Report describes experiment to investigate effects of isotonic and isokinetic leg exercises in counteracting effects of bed rest upon physical and mental conditions of subjects. Data taken on capacity for work, endurance and strength, tolerance to sitting up, equilibrium, posture, gait, atrophy, mineralization and density of bones, endocrine analyses concerning vasoactivity and fluid and electrolyte balances, intermediary metabolism of muscles, mood, and performance.

  17. The Amsterdam Resting-State Questionnaire reveals multiple phenotypes of resting-state cognition

    Directory of Open Access Journals (Sweden)

    B. Alexander eDiaz

    2013-08-01

    Full Text Available Resting-state neuroimaging is a dominant paradigm for studying brain function in health and disease. It is attractive for clinical research because of its simplicity for patients, straightforward standardization, and sensitivity to brain disorders. Importantly, non-sensory experiences like mind wandering may arise from ongoing brain activity. However, little is known about the link between ongoing brain activity and cognition, as phenotypes of resting-state cognition—and tools to quantify them—have been lacking. To facilitate rapid and structured measurements of resting-state cognition we developed a 50-item self-report survey, the Amsterdam Resting-State Questionnaire (ARSQ. Based on ARSQ data from 813 participants assessed after five minutes eyes-closed rest in their home, we identified seven dimensions of resting-state cognition using factor analysis: Discontinuity of Mind, Theory of Mind, Self, Planning, Sleepiness, Comfort, and Somatic Awareness. Further, we showed that the structure of cognition was similar during resting-state fMRI and EEG, and that the test-retest correlations were remarkably high for all dimensions. To explore whether inter-individual variation of resting-state cognition is related to health status, we correlated ARSQ-derived factor scores with psychometric scales measuring depression, anxiety, and sleep quality. Mental health correlated positively with Comfort and negatively with Discontinuity of Mind. Finally, we show that sleepiness may partially explain a resting-state EEG profile previously associated with Alzheimer’s disease. These findings indicate that the ARSQ readily provides information about cognitive phenotypes and that it is a promising tool for research on the neural correlates of resting-state cognition in health and disease.

  18. Annihilation of antiproton on deuteron at rest

    International Nuclear Information System (INIS)

    The system of Faddeev equations for amplitudes of anti pD iteraction at rest accounting for higher partial anti NN waves is derived. From its solution the total and elastic anti pD cross sections are calculated. Predictions for the missing-mass spectrum in the anti pD annihilation are made. The P-wave anti NN states give small contribution to the anti pD cross section at rest, the theoretical value of the latter being less than the experimental cross section extrapolated to the threshold. Let us emphasize that the total anti pD cross section depending weakly on the radii of anti NN interactions is sensitive to the values of the anti NN scattering lengths. Experimental data for anti pD cross sections at rest can be obtained only by extrapolation procedure. Henceforth it is very important to investigate the anti pD interactions at low but non-zero momenta where the direct comparison to the experiment is possible

  19. Tolerogenicity of resting and activated B cells

    OpenAIRE

    1994-01-01

    Antigen presentation by resting splenic B cells has been shown previously to induce T helper 1 cell (Th1) anergy. In contrast to expectations, it was found here that B cells treated with F(ab')2 goat anti-mouse immunoglobulin (IgM) for 24 or 48 h also presented antigen (Ag) to Th1 cells in a manner that induced dramatic Ag-specific proliferative inactivation. The tolerogenicity of the anti-Ig-treated B cells was consistent with the observation that these B cells were only slightly more effici...

  20. REST represses a subset of the pancreatic endocrine differentiation program

    DEFF Research Database (Denmark)

    Martin, David; Kim, Yung-Hae; Sever, Dror;

    2015-01-01

    neurons and in endocrine cells, which is necessary for their normal function. During development, REST represses a subset of genes in the neuronal differentiation program and Rest is down-regulated as neurons differentiate. Here, we investigate the role of REST in the differentiation of pancreatic...... REST is active in pancreas progenitors where it gates the activation of part of the beta cell differentiation program....

  1. Calculations of the Wigner angle

    International Nuclear Information System (INIS)

    Two new methods to determine Wigner's angle in special relativity are presented. The first one consists in calculating the angle between the compositions u-bar x ν-bar and ν-bar x u-bar of the two non-collinear velocities u-bar and ν-bar. In another method we introduce a generalization in the complex plane of Einstein's addition law of parallel velocities. (author)

  2. Rescaled range analysis of resting respiration

    Science.gov (United States)

    Hoop, Bernard; Kazemi, Homayoun; Liebovitch, Larry

    1993-01-01

    Fluctuations in resting depth of breathing (tidal volume) at constant breathing rate in the anesthetized adult rat exhibit fractal properties when analyzed by a rescaled range method characterized by a mean (±SD) exponent H=0.83±0.02 and 0.92±0.03 with and without sighs, respectively, for up to 400 breaths. Values of H determined from shuffled tidal volumes and simulated tidal volumes taken randomly from a Gaussian distribution of mean and variance approximating that of the actual data are consistent with the expected value of H=0.5 for an independent random process with finite variances. An empirical description is proposed to predict the change in H with length of time record.

  3. TaaS for Improving Quality of Restful Web Services

    OpenAIRE

    Shueh-Cheng Hu; I-Ching Chen

    2013-01-01

    In view of its critical role and popularity in the area of software architecting, Internet of things, and software as a service, a method for improving restful Web service programs' quality obviously is critical and valuable. Consequently, this article presents a service for improving the efficiency of testing restful Web service programs, the corresponding design rationale and impact are described. This kind of services will be helpful in speeding up the testing tasks of restful Web applicat...

  4. REST represses a subset of the pancreatic endocrine differentiation program.

    Science.gov (United States)

    Martin, David; Kim, Yung-Hae; Sever, Dror; Mao, Chai-An; Haefliger, Jacques-Antoine; Grapin-Botton, Anne

    2015-09-15

    To contribute to devise successful beta-cell differentiation strategies for the cure of Type 1 diabetes we sought to uncover barriers that restrict endocrine fate acquisition by studying the role of the transcriptional repressor REST in the developing pancreas. Rest expression is prevented in neurons and in endocrine cells, which is necessary for their normal function. During development, REST represses a subset of genes in the neuronal differentiation program and Rest is down-regulated as neurons differentiate. Here, we investigate the role of REST in the differentiation of pancreatic endocrine cells, which are molecularly close to neurons. We show that Rest is widely expressed in pancreas progenitors and that it is down-regulated in differentiated endocrine cells. Sustained expression of REST in Pdx1(+) progenitors impairs the differentiation of endocrine-committed Neurog3(+) progenitors, decreases beta and alpha cell mass by E18.5, and triggers diabetes in adulthood. Conditional inactivation of Rest in Pdx1(+) progenitors is not sufficient to trigger endocrine differentiation but up-regulates a subset of differentiation genes. Our results show that the transcriptional repressor REST is active in pancreas progenitors where it gates the activation of part of the beta cell differentiation program. PMID:26156633

  5. Effects of a Resting Foot Splint in Early Brain Injury Patients

    Science.gov (United States)

    Sung, Eun Jung; Hong, Ja Young; Do, Kyung Hee

    2016-01-01

    Objective To assess the effectiveness of the resting foot splint to prevent ankle contracture. Methods We performed a randomized controlled trial in 33 patients with brain injury with ankle dorsiflexor weakness (muscle power ≤grade 2). Both groups continued conventional customized physical therapy, but the patients in the foot splint group were advised to wear a resting foot splint for more than 12 hours per day for 3 weeks. The data were assessed before and 3 weeks after the study. The primary outcome was the change in ankle dorsiflexion angle after 3 weeks. Results Before the study, there were no differences between groups in gender, age, time post-injury, brain injury type, initial edema, spasticity, passive range of ankle dorsiflexion, Fugl-Meyer score (FMS), or Functional Ambulation Classification. A significant improvement in ankle dorsiflexion angle, and FMS was found after 3 weeks in both groups. The splint group showed more spasticity than the control group after 3 weeks (p=0.04). The change of ankle dorsiflexion angle, foot circumference, spasticity, and FMS after adjusting initial value and spasticity were not significantly different between the 2 groups. Conclusion Wearing a resting foot splint for 3 weeks did not affect joint mobility in patients with subacute brain injury regularly attending personalized rehabilitation programs. Further studies of larger sample sizes with well controlled in spasticity are required to evaluate the effects of the resting foot splint. PMID:26949680

  6. Disorders of the cerebellopontine angle

    International Nuclear Information System (INIS)

    Disorders of the cerebellopontine angle may present by symptoms like vertigo, hearing problems, affection of the trigeminal or facial nerve. Ipsilateral ataxia and contralateral hemiparesis develop in case of a rather large tumor in this region and display an involvement of the cerebellum and/or brainstem. However, some of these typical symptoms are not recognized by the patient. Thus, in case of a suspicion of a disorder of the cerebellopontine angle the relevant functions have to be tested clinically. In addition, electrophysiology can confirm dysfunction of these cranial nerves. Mainstay of the therapy should be the treatment of the underlying cause. Nevertheless, not seldom it is necessary to treat symptoms like vertigo or facial pain. (orig.)

  7. Restful Implementation of Catalogue Service for Geospatial Data Provenance

    Science.gov (United States)

    Jiang, L. C.; Yue, P.; Lu, X. C.

    2013-10-01

    Provenance, also known as lineage, is important in understanding the derivation history of data products. Geospatial data provenance helps data consumers to evaluate the quality and reliability of geospatial data. In a service-oriented environment, where data are often consumed or produced by distributed services, provenance could be managed by following the same service-oriented paradigm. The Open Geospatial Consortium (OGC) Catalogue Service for the Web (CSW) is used for the registration and query of geospatial data provenance by extending ebXML Registry Information Model (ebRIM). Recent advance of the REpresentational State Transfer (REST) paradigm has shown great promise for the easy integration of distributed resources. RESTful Web Service aims to provide a standard way for Web clients to communicate with servers based on REST principles. The existing approach for provenance catalogue service could be improved by adopting the RESTful design. This paper presents the design and implementation of a catalogue service for geospatial data provenance following RESTful architecture style. A middleware named REST Converter is added on the top of the legacy catalogue service to support a RESTful style interface. The REST Converter is composed of a resource request dispatcher and six resource handlers. A prototype service is developed to demonstrate the applicability of the approach.

  8. Identification of Resting State Networks Involved in Executive Function.

    Science.gov (United States)

    Connolly, Joanna; McNulty, Jonathan P; Boran, Lorraine; Roche, Richard A P; Delany, David; Bokde, Arun L W

    2016-06-01

    The structural networks in the human brain are consistent across subjects, and this is reflected also in that functional networks across subjects are relatively consistent. These findings are not only present during performance of a goal oriented task but there are also consistent functional networks during resting state. It suggests that goal oriented activation patterns may be a function of component networks identified using resting state. The current study examines the relationship between resting state networks measured and patterns of neural activation elicited during a Stroop task. The association between the Stroop-activated networks and the resting state networks was quantified using spatial linear regression. In addition, we investigated if the degree of spatial association of resting state networks with the Stroop task may predict performance on the Stroop task. The results of this investigation demonstrated that the Stroop activated network can be decomposed into a number of resting state networks, which were primarily associated with attention, executive function, visual perception, and the default mode network. The close spatial correspondence between the functional organization of the resting brain and task-evoked patterns supports the relevance of resting state networks in cognitive function. PMID:26935902

  9. Resting stage cells of diatoms in deep waters in Kumano-

    OpenAIRE

    AKIRA, ISHIKAWA; Shingo, Kitami; Ken-Ichiro, Ishii; Toru, NAKAMURA; ICHIRO, IMAI

    2011-01-01

    The abundance and species composition of viable resting stage cells of diatoms were investigated in deep waters (200,500 and 1,000 m depths) collected at neighboring stations in Kumano-Nada, central part of Japan, in April, August and October 2006. Viable resting stage cells were enumerated by the modified extinction dilution method [most probable number (MPN) method] based on incubation. Resting stage cells were detected from all samples, except at 500 m depth in August, in a range of abunda...

  10. RESTful NET

    CERN Document Server

    Flanders, Jon

    2008-01-01

    RESTful .NET is the first book that teaches Windows developers to build RESTful web services using the latest Microsoft tools. Written by Windows Communication Foundation (WFC) expert Jon Flanders, this hands-on tutorial demonstrates how you can use WCF and other components of the .NET 3.5 Framework to build, deploy and use REST-based web services in a variety of application scenarios. RESTful architecture offers a simpler approach to building web services than SOAP, SOA, and the cumbersome WS- stack. And WCF has proven to be a flexible technology for building distributed systems not necessa

  11. Opening Angles of Collapsar Jets

    OpenAIRE

    Mizuta, Akira; Ioka, Kunihito

    2013-01-01

    We investigate the jet propagation and breakout from the stellar progenitor for gamma-ray burst (GRB) collapsars by performing two-dimensional relativistic hydrodynamic simulations and analytical modeling. We find that the jet opening angle is given by $\\theta_j \\sim 1/5 \\Gamma_{0}$, and infer the initial Lorentz factor of the jet at the central engine, $\\Gamma_0$, is a few for existing observations of $\\theta_j$. The jet keeps the Lorentz factor low inside the star by converging cylindricall...

  12. Rest-to-Rest Attitude Naneuvers and Residual Vibration Reduction of a Finite Element Model of Flexible Satellite by Using Input Shaper

    Directory of Open Access Journals (Sweden)

    Setyamartana Parman

    1999-01-01

    Full Text Available A three-dimensional rest-to-rest attitude maneuver of flexible spacecraft equipped by on-off reaction jets is studied. Equations of motion of the spacecraft is developed by employing a hybrid system of coordinates and Lagrangian formulation. The finite element method is used to examine discrete elastic deformations of a particular model of satellite carrying flexible solar panels by modelling the panels as flat plate structures in bending. Results indicate that, under an unshaped input, the maneuvers induce undesirable attitude angle motions of the satellite as well as vibration of the solar panels. An input shaper is then applied to reduce the residual oscillation of its motion at several natural frequencies in order to get an expected pointing precision of the satellite. Once the shaped input is given to the satellite, the performance improves significantly.

  13. Effects of Flotation-REST on Muscle Tension Pain

    OpenAIRE

    Kjellgren, Anette; Sundequist, Ulf; Norlander, Torsten; Archer, Trevor

    2001-01-01

    The purpose of the present study was to investigate whether the floating form of the restricted environmental stimulation technique (REST) may be applied within the field of pain relief. Flotation-REST consists of a procedure whereby an individual is immersed in a tank filled with water of an extremely high salt concentration. Thirty-seven patients (14 men and 23 women) suffering from chronic pain consisting of aching muscles in the neck and back area participated in the study. They were rand...

  14. The qualitative criterion of transient angle stability

    OpenAIRE

    Lyu, R; Xue, Y.; Xue, F; Wu, Qiuwei; Yang, Guangya; Zhou, H; Ju, P.

    2015-01-01

    In almost all the literatures, the qualitative assessment of transient angle stability extracts the angle information of generators based on the swing curve. As the angle (or angle difference) of concern and the threshold value rely strongly on the engineering experience, the validity and robust of these criterions are weak. Based on the stability mechanism from the extended equal area criterion (EEAC) theory and combining with abundant simulations of real system, this paper analyzes the crit...

  15. Moderating effects of music on resting state networks

    OpenAIRE

    Kay, Benjamin P; Meng, Xiangxiang; DiFrancesco, Mark; Holland, Scott K.; Szaflarski, Jerzy P.

    2012-01-01

    Resting state networks (RSNs) are spontaneous, synchronous, low-frequency oscillations observed in the brains of subjects who are awake but at rest. A particular RSN called the default mode network (DMN) has been shown to exhibit changes associated with neurological disorders such as temporal lobe epilepsy or Alzheimer’s disease. Previous studies have also found that differing experimental conditions such as eyes-open versus eyes-closed can produce measurable changes in the DMN. These conditi...

  16. Resting states are resting traits - an fMRI study of sex differences and menstrual cycle effects in resting state cognitive control networks.

    OpenAIRE

    Helene Hjelmervik; Markus Hausmann; Berge Osnes; René Westerhausen; Karsten Specht

    2014-01-01

    To what degree resting state fMRI is stable or susceptible to internal mind states of the individual is currently an issue of debate. To address this issue, the present study focuses on sex differences and investigates whether resting state fMRI is stable in men and women or changes within relative short-term periods (i.e., across the menstrual cycle). Due to the fact that we recently reported menstrual cycle effects on cognitive control based on data collected during the same sessions, the c...

  17. Regulation and role of REST and REST4 variants in modulation of gene expression in in vivo and in vitro in epilepsy models.

    Science.gov (United States)

    Spencer, E M; Chandler, K E; Haddley, K; Howard, M R; Hughes, D; Belyaev, N D; Coulson, J M; Stewart, J P; Buckley, N J; Kipar, A; Walker, M C; Quinn, J P

    2006-10-01

    Repressor element-1 silencing transcription factor (REST) is a candidate modulator of gene expression during status epilepticus in the rodent. In such models, full-length REST and the truncated REST4 variant are induced and can potentially direct differential gene expression patterns. We have addressed the regulation of these REST variants in rodent hippocampal seizure models and correlated this with expression of the proconvulsant, substance P encoding, PPT-A gene. REST and REST4 were differentially regulated following kainic acid stimulus both in in vitro and in vivo models. REST4 was more tightly regulated than REST in both models and its transient expression correlated with that of the differential regulation of PPT-A. Consistent with this, overexpression of a truncated REST protein (HZ4, lacking the C-terminal repression domain) increased expression of the endogenous PPT-A gene. Similarly the proximal PPT-A promoter reporter gene construct was differentially regulated by the distinct REST isoforms in hippocampal cells with HZ4 being the major inducer of increased reporter expression. Furthermore, REST and REST4 proteins were differentially expressed and compartmentalized within rat hippocampal cells in vitro following noxious stimuli. This differential localization of the REST isoforms was confirmed in the CA1 region following perforant path and kainic acid induction of status epilepticus in vivo. We propose that the interplay between REST and REST4 alter the expression of proconvulsant genes, as exemplified by the PPT-A gene, and may therefore regulate the progression of epileptogenesis. PMID:16828291

  18. Effects of Bed Rest on Conduction Velocity of the Triceps Surae Stretch Reflex and Postural Control

    Science.gov (United States)

    Reschke, M. F.; Wood, S. J.; Cerisano, J. M.; Kofman, I. S.; Fisher, E. A.; Esteves, J. T.; Taylor, L. C.; DeDios, Y. E.; Harm, D. L.

    2011-01-01

    Despite rigorous exercise and nutritional management during space missions, astronauts returning from microgravity exhibit neuromuscular deficits and a significant loss in muscle mass in the postural muscles of the lower leg. Similar changes in the postural muscles occur in subjects participating in long-duration bed rest studies. These adaptive muscle changes manifest as a reduction in reflex conduction velocity during head-down bed rest. Because the stretch reflex encompasses both the peripheral (muscle spindle and nerve axon) and central (spinal synapse) components involved in adaptation to calf muscle unloading, it may be used to provide feedback on the general condition of neuromuscular function, and might be used to evaluate the effectiveness of countermeasures aimed at preserving muscle mass and function during periods of unloading. Stretch reflexes were measured on 18 control subjects who spent 60 to 90 days in continuous 6 deg head-down bed rest. Using a motorized system capable of rotating the foot around the ankle joint (dorsiflexion) through an angle of 10 degrees at a peak velocity of about 250 deg/sec, a stretch reflex was recorded from the subject's left triceps surae muscle group. Using surface electromyography, about 300 reflex responses were obtained and ensemble-averaged on 3 separate days before bed rest, 3 to 4 times in bed, and 3 times after bed rest. The averaged responses for each test day were examined for reflex latency and conduction velocity (CV) across gender. Computerized posturography was also conducted on these same subjects before and after bed rest as part of the standard measures. Peak-to-peak sway was measured during Sensory Organization Tests (SOTs) to evaluate changes in the ability to effectively use or suppress visual, vestibular, and proprioceptive information for postural control. Although no gender differences were found, a significant increase in reflex latency and a significant decrease in CV were observed during the bed

  19. Feasibility Study of a Lunar Analog Bed Rest Model

    Science.gov (United States)

    Cromwell, Ronita L.; Platts, Steven H.; Yarbough, Patrice; Buccello-Stout, Regina

    2010-01-01

    The purpose of this study was to determine the feasibility of using a 9.5deg head-up tilt bed rest model to simulate the effects of the 1/6 g load to the human body that exists on the lunar surface. The lunar analog bed rest model utilized a modified hospital bed. The modifications included mounting the mattress on a sled that rolled on bearings to provide freedom of movement. The weight of the sled was off-loaded using a counterweight system to insure that 1/6 body weight was applied along the long axis (z-axis) of the body. Force was verified through use of a force plate mounted at the foot of the bed. A seating assembly was added to the bed to permit periods of sitting. Subjects alternated between standing and sitting positions throughout the day. A total of 35% of the day was spent in the standing position and 65% was spent sitting. In an effort to achieve physiologic fluid shifts expected for a 1/6 G environment, subjects wore compression stockings and performed unloaded foot and ankle exercises. Eight subjects (3 females and 5 males) participated in this study. Subjects spent 13 days in the pre-bed rest phase, 6 days in bed rest and 3 days post bed rest. Subjects consumed a standardized diet throughout the study. To determine feasibility, measures of subject comfort, force and plasma volume were collected. Subject comfort was assessed using a Likert scale. Subjects were asked to assess level of comfort (0-100) for 11 body regions and provide an overall rating. Results indicated minimal to no discomfort as most subjects reported scores of zero. Force measures were performed for each standing position and were validated against subject s calculated 1/6 body weight (r(sup 2) = 0.993). The carbon monoxide rebreathing technique was used to assess plasma volume during pre-bed rest and on the last day of bed rest. Plasma volume results indicated a significant decrease (p = 0.001) from pre to post bed rest values. Subjects lost on average 8.3% (sd = 6.1%) during the

  20. Evaluation of blotchy pigments in the anterior chamber angle as a sign of angle closure

    Directory of Open Access Journals (Sweden)

    Harsha L Rao

    2012-01-01

    Full Text Available Background: Blotchy pigments in the anterior chamber (AC angle are considered diagnostic of primary angle closure (PAC. But there are no reports either on the prevalence of blotchy pigments in AC angles or the validity of this sign. Aims: To determine the prevalence of blotchy pigments in AC angles and to evaluate their relationship with glaucomatous optic neuropathy (GON in eyes with occludable angles. Setting and Design: Cross-sectional, comparative study. Materials and Methods: Gonioscopy was performed in 1001 eyes of 526 subjects (245 eyes of 148 consecutive, occludable angle subjects and 756 eyes of 378 non-consecutive, open angle subjects, above 35 years of age. Quadrant-wise location of blotchy pigments was documented. Statistical Analysis: Odds of blotchy pigments in occludable angles against that in open angles were evaluated. Relationship of GON with blotchy pigments in occludable angle eyes was evaluated using a multivariate model. Results: Prevalence of blotchy pigments in occludable angles was 28.6% (95% CI, 22.9-34.3 and in open angles was 4.7% (95% CI, 3.2-6.3. Blotchy pigments were more frequently seen in inferior (16% and superior quadrants (15% of occludable angles, and inferior quadrant of open angles (4%. Odds of superior quadrant blotchy pigments in occludable angles were 33 times that in open angles. GON was seen in 107 occludable angle eyes. Blotchy pigments were not significantly associated with GON (odds ratio = 0.5; P = 0.1. Conclusions: Blotchy pigments were seen in 28.6% of occludable angle eyes and 4.7% of open angles eyes. Presence of blotchy pigments in the superior quadrant is more common in occludable angles. Presence of GON in occludable angle eyes was not associated with blotchy pigments.

  1. Resting Behaviour of Broilers in Three Different Rearing Systems

    Directory of Open Access Journals (Sweden)

    Zupan, M.

    2003-09-01

    Full Text Available The highest number of broilers is reared in the intensive fattening system on the floor with litter. Besides the intensive systems some sustainable rearing ways are also brought forward (ecological, biologic-dynamic, organic, etc.. The aim of this study was to establish the possible differences in resting behaviour of broilers in three rearing systems: intensive on the floor, free range, and organic system. The results showed great varieties between intensive and less intensive systems. In the intensive system on the floor animals rested statistically highly significantly more than in other two systems. However no differences in the behaviour of broilers in the stall were noticed, ifcompared to broilers in free range and those in the organic system. Comparison of the outdoor area showed that broilers rested statistically significantly more in the organic system. The reasons for different resting behaviour could be in leg weakness, body weight, group size, health problems, age, housing system, etc. Our research did not confirm our hypothesis that the older broilers rest more.

  2. Assessment of OGC Web Processing Services for REST principles

    CERN Document Server

    Granell, Carlos; Tamayo, Alain; Huerta, Joaquín

    2012-01-01

    Recent distributed computing trends advocate the use of Representational State Transfer (REST), which aligns to the same principles than shape the Web, to alleviate the inherent complexity of the Web services standards in building service-oriented web applications. In this paper, we focus on the particular case of geospatial services interfaced by the OGC Web Processing Service (WPS) specification, geoprocessing services on top of service oriented architectures, in order to assess whether WPS-based geoprocessing services can be viewed from the architectural principles exposed in REST. Our concluding remarks suggest that the adoption of REST principles, to specially harness the built-in mechanisms of the HTTP application protocol, may be beneficial in scenarios where ad hoc composition of geoprocessing services are required, common for most non-expert users of geospatial information infrastructures.

  3. Effect of Smoking on Blood Pressure and Resting Heart Rate

    DEFF Research Database (Denmark)

    Linneberg, Allan; Jacobsen, Rikke K; Skaaby, Tea;

    2015-01-01

    BACKGROUND: -Smoking is an important cardiovascular disease risk factor, but the mechanisms linking smoking to blood pressure are poorly understood. METHODS AND RESULTS: -Data on 141,317 participants (62,666 never, 40,669 former, 37,982 current smokers) from 23 population-based studies were...... included in observational and Mendelian randomisation (MR) meta-analyses of the associations of smoking status and smoking heaviness with systolic and diastolic blood pressure (SBP, DBP), hypertension, and resting heart rate. For the MR analyses, a genetic variant rs16969968/rs1051730 was used as a proxy...... association of smoking heaviness with higher level of resting heart rate, but not with blood pressure. These findings suggest that part of the cardiovascular risk of smoking may operate through increasing resting heart rate....

  4. Expression of REST4 in human gliomas in vivo and influence of pioglitazone on REST in vitro

    Energy Technology Data Exchange (ETDEWEB)

    Ren, Huan [Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008 (China); Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078 (China); Gao, Zhangfeng [Department of Neurosurgery, Second Xiangya Hospital of Central South University, Changsha 410008 (China); Wu, Nayiyuan; Zeng, Liu; Tang, Xinyue; Chen, Xiaoping; Liu, Zhaoqian; Zhang, Wei; Wang, Liansheng [Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008 (China); Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078 (China); Li, Zhi, E-mail: lizhi489@163.com [Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008 (China); Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078 (China)

    2015-08-07

    The repressor element-1 (RE1) silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) has an irreplaceable role during the differentiation of neurons. REST has multiple splice variants which link to various types of cancer. Previous work had highlighted the role of REST in glioma, where the expression of REST is enhanced. But whether alternative splicing of REST is expressed in glioma has not been described. Here, we show that a specific isoform REST4 is expressed in glioma specimens, and will influence the mRNA level of REST in vivo. Peroxisome proliferator-activated receptor-γ (PPARγ) agonists have a role of antineoplastic in various tumor cells, which including glioma cells. Moreover, study indicated that PPARγ agonist pioglitazone can promote alternative splicing of REST pre-mRNA. In this study, we selected pioglitazone as a tool drug to explore whether the role of pioglitazone in anti-glioma is mediated by regulating REST expression or promoting alternative splicing of REST in glioma cells. Results show that pioglitazone can inhibit proliferation and induce apoptosis of glioma cell in vitro, which may be mediated by down-regulating REST mRNA level but not by inducing alternative splicing of REST pre-mRNA. Our study firstly reports the expression of REST4 in glioma tissue samples. And we recommend that pioglitazone, which can reduce the expression level of REST, represents a promising drug for therapy of glioma. - Highlights: • A specific isoform REST4 is expressed in glioma specimens in vivo. • REST4 will influence the mRNA level of REST in vivo. • Pioglitazone can inhibit proliferation and induce apoptosis of glioma cells. • The role of pioglitazone in anti-glioma may be mediated by down-regulating REST.

  5. Effects of an interatrial shunt on rest and exercise hemodynamics

    DEFF Research Database (Denmark)

    Kaye, David; Shah, Sanjiv J; Borlaug, Barry A; Gustafsson, Finn; Komtebedde, Jan; Kubo, Spencer; Magnin, Chris; Maurer, Mathew S; Feldman, Ted; Burkhoff, Daniel

    2014-01-01

    BACKGROUND: A treatment based on an interatrial shunt device has been proposed for counteracting elevated pulmonary capillary wedge pressure (PCWP) in patients with heart failure and mildly reduced or preserved ejection fraction (HFpEF). We tested the theoretical hemodynamic effects of this...... approach with the use of a previously validated cardiovascular simulation. METHODS AND RESULTS: Rest and exercise hemodynamics data from 2 previous independent studies of patients with HFpEF were simulated. The theoretical effects of a shunt between the right and left atria (diameter up to 12 mm) were...... determined. The interatrial shunt lowered PCWP by ~3 mm Hg under simulated resting conditions (from 10 to 7 mm Hg) and by ~11 mm Hg under simulated peak exercise conditions (from 28 to 17 mm Hg). Left ventricular cardiac output decreased ~0.5 L/min at rest and ~1.3 L/min at peak exercise, with corresponding...

  6. Retrospective Study of Serum Sclerostin Measurements in Bed Rest Subjects

    Science.gov (United States)

    Spatz, J. M.; Fields, E. E.; Yu, E. W.; Divieti, Pajevic P.; Bouxsein, M. L.; Sibonga, M. L.; Zwart, S. R.; Smith, S. M.

    2011-01-01

    Animal models and human studies suggest that osteocytes regulate the skeleton s response to mechanical unloading at the cellular level in part by an increase in sclerostin, an inhibitor of the anabolic Wnt pathway. However, few studies have reported changes in serum sclerostin in humans exposed to reduced mechanical loading. Thus, we determined changes in serum sclerostin and bone turnover markers in healthy adult men who participated in a controlled bed rest study. Seven healthy adult men (31 +/- 3 yrs old) underwent 90-day six-degree head down tilt bed rest at the University of Texas Medical Branch in Galveston's Institute for Translational Sciences - Clinical Research Center (ITS-CRC). Serum sclerostin, PTH, serum markers of bone turnover (bone specific alkaline phosphatase, RANKL/OPG, and osteocalcin), urinary calcium and phosphorus excretion, and 24 hour pooled urinary markers of bone resorption (NTX, DPD, PYD) were evaluated pre-bed rest (BL), bed rest day 28 (BR-28), bed rest day 60 (BR-60), and bed rest day 90 (BR-90). In addition, bone mineral density (BMD) was assessed by dual-energy X-ray absorptiometry (DXA) at BL, BR-60, and post bed rest day 5 (BR+5). Data are reported as mean +/- standard deviation. We used repeated measures ANOVA to compare baseline values to BR-28, BR-60, and BR-90. RESULTS Consistent with prior reports, BMD declined significantly (1-2% per month) at weight-bearing skeletal sites (spine, hip, femur neck, and calcaneus). Serum sclerostin levels were elevated above BL at BR-28 (+29% +/- 20%, p = 0.003), BR-60 (+42% +/- 31%, p < 0.001), and BR-90 (22% +/- 21%, p = 0.07). Serum PTH levels were reduced at BR-28 (-17% +/- 16%, p = 0.02), BR-60 (-24% +/- 14%, p = 0.03), and returned to baseline at BR-90 (-21% +/- 21%, p = 0.14). Serum bone turnover markers did not change, however urinary bone resorption markers and calcium were significantly elevated following bed rest (p < 0.01). CONCLUSION We observed an increase of serum sclerostin

  7. Pitch angle of galactic spiral arms

    International Nuclear Information System (INIS)

    One of the key parameters that characterizes spiral arms in disk galaxies is a pitch angle that measures the inclination of a spiral arm to the direction of galactic rotation. The pitch angle differs from galaxy to galaxy, which suggests that the rotation law of galactic disks determines it. In order to investigate the relation between the pitch angle of spiral arms and the shear rate of galactic differential rotation, we perform local N-body simulations of pure stellar disks. We find that the pitch angle increases with the epicycle frequency and decreases with the shear rate and obtain the fitting formula. This dependence is explained by the swing amplification mechanism.

  8. OPTIMIZATION OF TILT ANGLE FOR PHOTOVOLTAIC ARRAY

    OpenAIRE

    Ashok Kumar; N.S.Thakur,; Rahul Makade,; Maneesh Kumar Shivhar

    2011-01-01

    The performance of a solar radiation conversion system is affected by its tilt angle with the horizontal plane, thus photovoltaic array need to be tilted at the correct angle to maximize the performance of the System, This paper deals with the determination of optimum tilt angle for solar PV array in order to maximize incident solar irradiance. The model starts by calculating the monthly averaged daily solar irradiation components (direct, diffuse, ground- eflected) absorbed by the solar PV a...

  9. GBAR. Graviational behavior of antihydrogen at rest

    International Nuclear Information System (INIS)

    The GBAR project aims to perform the first test of the Equivalence Principle with antimatter by measuring the free fall of ultra-cold antihydrogen atoms. The objective is to measure the gravitational acceleration to better than a percent in a first stage, with a long term perspective to reach a much higher precision using gravitational quantum states of antihydrogen. The production of ∼20 μK atoms proceeds via sympathetic cooling of H-bar+ ions by Be+ ions. H-bar+ ions are produced via a two-step process, involving the interaction of bursts of 107 slow antiprotons from the AD (or ELENA upgrade) at CERN with a dense positronium cloud. In order to produce enough positronium, it is necessary to realize an intense source of slow positrons, a few 108 per second. This is done with a small electron linear accelerator. A few 1010 positrons are accumulated every cycle in a Penning–Malmberg trap before they are ejected onto a positron-to-positronium converter. The overall scheme of the experiment is described and the status of the installation of the prototype positron source at Saclay is shown. The accumulation scheme of positrons is given, and positronium formation results are presented. The estimated performance and efficiency of the various steps of the experiment are given.

  10. The qualitative criterion of transient angle stability

    DEFF Research Database (Denmark)

    Lyu, R.; Xue, Y.; Xue, F.;

    2015-01-01

    In almost all the literatures, the qualitative assessment of transient angle stability extracts the angle information of generators based on the swing curve. As the angle (or angle difference) of concern and the threshold value rely strongly on the engineering experience, the validity and robust of...... these criterions are weak. Based on the stability mechanism from the extended equal area criterion (EEAC) theory and combining with abundant simulations of real system, this paper analyzes the criterions in most literatures and finds that the results could be too conservative or too optimistic. It is...

  11. Democracy in the Rest of the Americas.

    Science.gov (United States)

    Breslin, Patrick

    1991-01-01

    Describes the role of nongovernmental organizations (NGOs) in the political arena, as well as in development and public welfare roles. Traces the recent history of grassroots efforts to solve social problems in Latin America. NGOs can strengthen institution building and influence national policymaking. (KS)

  12. Separation of uranium in bone rest for their dating

    International Nuclear Information System (INIS)

    The uranium (U) and thorium (Th) recovery, as fundamental part of the 'uranium serie' technique is an alternative method for dating of bone rests in Mexico. That so is how it has been possible its application for dating geological material and in this research it has been determined the age of some mammoth samples from the basin of Mexico valley. (Author)

  13. Recitations for the Rest of Us

    Science.gov (United States)

    Sisson, Cynthia

    2010-10-01

    Two-thirds of Physics Departments in the United States offer a Bachelor's degree as their highest degree. At these institutions, the ability to offer a separate recitation for introductory physics courses can be severely limited by the lack of graduate Teaching Assistants and existing teaching commitments within the department. At Louisiana State University in Shreveport a combination of course redesign and technology have been used over the last three years to add an active-learning problem solving recitation within the existing framework of introductory physics courses. One day per week of a three-day-per-week, 50 minute class period is now used for a tablet-computer based recitation, in which students work in collaborative groups on problems while the professor monitors group progress and presents exemplar student solutions to the class in real time. This talk will discuss the structural redesign to the courses, the technology tools (hardware and software) that are being used, and suggest alternative methods that do not require technology. In addition, student data relating to course outcomes in the redesigned courses will be presented for conceptual learning gains, problem solving skills, overall course success, and student-reported attitudes towards course outcomes, showing the positive results of these changes.

  14. Behavior of Tilted Angle Shear Connectors.

    Directory of Open Access Journals (Sweden)

    Koosha Khorramian

    Full Text Available According to recent researches, angle shear connectors are appropriate to transfer longitudinal shear forces across the steel-concrete interface. Angle steel profile has been used in different positions as L-shaped or C-shaped shear connectors. The application of angle shear connectors in tilted positions is of interest in this study. This study investigates the behaviour of tilted-shaped angle shear connectors under monotonic loading using experimental push out tests. Eight push-out specimens are tested to investigate the effects of different angle parameters on the ultimate load capacity of connectors. Two different tilted angles of 112.5 and 135 degrees between the angle leg and steel beam are considered. In addition, angle sizes and lengths are varied. Two different failure modes were observed consisting of concrete crushing-splitting and connector fracture. By increasing the size of connector, the maximum load increased for most cases. In general, the 135 degrees tilted angle shear connectors have a higher strength and stiffness than the 112.5 degrees type.

  15. Resting state networks and consciousness: alterations of multiple resting state network connectivity in physiological, pharmacological, and pathological consciousness States.

    Science.gov (United States)

    Heine, Lizette; Soddu, Andrea; Gómez, Francisco; Vanhaudenhuyse, Audrey; Tshibanda, Luaba; Thonnard, Marie; Charland-Verville, Vanessa; Kirsch, Murielle; Laureys, Steven; Demertzi, Athena

    2012-01-01

    In order to better understand the functional contribution of resting state activity to conscious cognition, we aimed to review increases and decreases in functional magnetic resonance imaging (fMRI) functional connectivity under physiological (sleep), pharmacological (anesthesia), and pathological altered states of consciousness, such as brain death, coma, vegetative state/unresponsive wakefulness syndrome, and minimally conscious state. The reviewed resting state networks were the DMN, left and right executive control, salience, sensorimotor, auditory, and visual networks. We highlight some methodological issues concerning resting state analyses in severely injured brains mainly in terms of hypothesis-driven seed-based correlation analysis and data-driven independent components analysis approaches. Finally, we attempt to contextualize our discussion within theoretical frameworks of conscious processes. We think that this "lesion" approach allows us to better determine the necessary conditions under which normal conscious cognition takes place. At the clinical level, we acknowledge the technical merits of the resting state paradigm. Indeed, fast and easy acquisitions are preferable to activation paradigms in clinical populations. Finally, we emphasize the need to validate the diagnostic and prognostic value of fMRI resting state measurements in non-communicating brain damaged patients. PMID:22969735

  16. Resting state activity in patients with disorders of consciousness

    Science.gov (United States)

    Soddu, Andrea; Vanhaudenhuyse, Audrey; Demertzi, Athena; Bruno, Marie-Aurélie; Tshibanda, Luaba; Di, Haibo; Boly, Mélanie; Papa, Michele; Laureys, Steven; Noirhomme, Quentin

    Summary Recent advances in the study of spontaneous brain activity have demonstrated activity patterns that emerge with no task performance or sensory stimulation; these discoveries hold promise for the study of higher-order associative network functionality. Additionally, such advances are argued to be relevant in pathological states, such as disorders of consciousness (DOC), i.e., coma, vegetative and minimally conscious states. Recent studies on resting state activity in DOC, measured with functional magnetic resonance imaging (fMRI) techniques, show that functional connectivity is disrupted in the task-negative or the default mode network. However, the two main approaches employed in the analysis of resting state functional connectivity data (i.e., hypothesis-driven seed-voxel and data-driven independent component analysis) present multiple methodological difficulties, especially in non-collaborative DOC patients. Improvements in motion artifact removal and spatial normalization are needed before fMRI resting state data can be used as proper biomarkers in severe brain injury. However, we anticipate that such developments will boost clinical resting state fMRI studies, allowing for easy and fast acquisitions and ultimately improve the diagnosis and prognosis in the absence of DOC patients’ active collaboration in data acquisition. PMID:21693087

  17. Resting state activity in patients with disorders of consciousness.

    Science.gov (United States)

    Soddu, Andrea; Vanhaudenhuyse, Audrey; Demertzi, Athena; Bruno, Marie-Aurélie; Tshibanda, Luaba; Di, Haibo; Mélanie, Boly; Papa, Michele; Laureys, Steven; Noirhomme, Quentin

    2011-01-01

    Recent advances in the study of spontaneous brain activity have demonstrated activity patterns that emerge with no task performance or sensory stimulation; these discoveries hold promise for the study of higher-order associative network functionality. Additionally, such advances are argued to be relevant in pathological states, such as disorders of consciousness (DOC), i.e., coma, vegetative and minimally conscious states. Recent studies on resting state activity in DOC, measured with functional magnetic resonance imaging (fMRI) techniques, show that functional connectivity is disrupted in the task-negative or the default mode network. However, the two main approaches employed in the analysis of resting state functional connectivity data (i.e., hypothesis-driven seed-voxel and data-driven independent component analysis) present multiple methodological difficulties, especially in non-collaborative DOC patients. Improvements in motion artifact removal and spatial normalization are needed before fMRI resting state data can be used as proper biomarkers in severe brain injury. However, we anticipate that such developments will boost clinical resting state fMRI studies, allowing for easy and fast acquisitions and ultimately improve the diagnosis and prognosis in the absence of DOC patients' active collaboration in data acquisition. PMID:21693087

  18. BIOSORPTION OF CR (VI BY RESTING CELLS OF ASPERGILLUS SP.

    Directory of Open Access Journals (Sweden)

    M. Sen , M. Ghosh Dastidar

    2007-01-01

    Full Text Available Biosorption of Cr(VI from aqueous solution was studied in a batch bioreactor using the resting cells of filamentous fungal biomass (Aspergillus sp. isolated from industrial wastewaters. The specific Cr(VI removal (mg/g of dried biomass decreased with increase in pH and increased with increase in initial Cr(VI concentration, upto 500 mg/L. By increasing biomass concentration from 2.4 to 5.2 g/L, the specific metal removal remained almost constant. The studies carried out by using the resting cells from various stages of growth indicated maximum Cr(VI removal of 34.8 mg/g using the biomass from the beginning of the stationary phase. The adsorption equilibrium constants Qº (42.9 mg/g and b (0.0091/mg were obtained from the Langmuir adsorption isotherm model.

  19. Spatiotemporal psychopathology I: No rest for the brain's resting state activity in depression? Spatiotemporal psychopathology of depressive symptoms.

    Science.gov (United States)

    Northoff, Georg

    2016-01-15

    Despite intense neurobiological investigation in psychiatric disorders like major depressive disorder (MDD), the basic disturbance that underlies the psychopathological symptoms of MDD remains, nevertheless, unclear. Neuroimaging has focused mainly on the brain's extrinsic activity, specifically task-evoked or stimulus-induced activity, as related to the various sensorimotor, affective, cognitive, and social functions. Recently, the focus has shifted to the brain's intrinsic activity, otherwise known as its resting state activity. While various abnormalities have been observed during this activity, their meaning and significance for depression, along with its various psychopathological symptoms, are yet to be defined. Based on findings in healthy brain resting state activity and its particular spatial and temporal structure - defined in a functional and physiological sense rather than anatomical and structural - I claim that the various depressive symptoms are spatiotemporal disturbances of the resting state activity and its spatiotemporal structure. This is supported by recent findings that link ruminations and increased self-focus in depression to abnormal spatial organization of resting state activity. Analogously, affective and cognitive symptoms like anhedonia, suicidal ideation, and thought disorder can be traced to an increased focus on the past, increased past-focus as basic temporal disturbance o the resting state. Based on these findings, I conclude that the various depressive symptoms must be conceived as spatiotemporal disturbances of the brain's resting state's activity and its spatiotemporal structure. Importantly, this entails a new form of psychopathology, "Spatiotemporal Psychopathology" that directly links the brain and psyche, therefore having major diagnostic and therapeutic implications for clinical practice. PMID:26048657

  20. Decreased Expression of CoREST1 and CoREST2 Together with LSD1 and HDAC1/2 during Neuronal Differentiation.

    Directory of Open Access Journals (Sweden)

    Julián Esteban Sáez

    Full Text Available CoREST (CoREST1, rcor1 transcriptional corepressor together with the histone demethylase LSD1 (KDM1A and the histone deacetylases HDAC1/2 form LSD1-CoREST-HDAC (LCH transcriptional complexes to regulate gene expression. CoREST1 belong to a family that also comprises CoREST2 (rcor2 and CoREST3 (rcor3. CoREST1 represses the expression of neuronal genes during neuronal differentiation. However, the role of paralogs CoREST2 and CoREST3 in this process is just starting to emerge. Here, we report the expression of all CoRESTs and partners LSD1 and HDAC1/2 in two models of neuronal differentiation: Nerve-Growth-Factor (NGF-induced neuronal phenotype of PC12 cells, and in vitro maturation of embryonic rat cortical neurons. In both models, a concomitant and gradual decrease of LSD1, HDAC1, HDAC2, CoREST1, and CoREST2, but not CoREST3 was observed. As required by the study, full-length rat rcor1 gene was identified using in silico analysis of available rat genome. The work was also complemented by the analysis of rat RNA-seq databases. The analysis showed that all CoRESTs, including the identified four splicing variants of rat CoREST3, display a wide expression in adult tissues. Moreover, the analysis of RNA-seq databases showed that CoREST2 displays a higher expression than CoREST1 and CoREST3 in the mature brain. Immunofluorescent assays and immunoblots of adult rat brain showed that all CoRESTs are present in both glia and neurons. Regarding functional partnership, CoREST2 and CoREST3 interact with all LSD1 splicing variants. In conclusion, neuronal differentiation is accompanied by decreased expression of all core components of LCH complexes, but not CoREST3. The combination of the differential transcriptional repressor capacity of LCH complexes and variable protein levels of its different components should result in a finely tuned gene expression during neuronal differentiation and in the adult brain.

  1. Resting and Energy Reserves of Aedes albopictus Collected in Common Landscaping Vegetation in St. Augustine, Florida

    OpenAIRE

    Samson, Dayana M.; Qualls, Whitney A.; Roque, Deborah; Naranjo, Diana P.; Alimi, Temitope; Arheart, Kristopher L.; Müller, Günter C; Beier, John C.; Xue, Rui-De

    2013-01-01

    The resting behavior of Aedes albopictus was evaluated by aspirating diurnal resting mosquitoes from common landscape vegetation in residential communities in St. Augustine, FL. Energy reserves of the resting mosquitoes were analyzed to determine if there was a correlation between mosquito resting habitat and energy accumulation. Six species of plants were selected and 9 collections of resting mosquitoes were aspirated from each plant using a modified John W. Hock backpack aspirator during Ju...

  2. Development of a restful API : hateoas & driven API

    OpenAIRE

    Somoza Alonso, Fernando

    2015-01-01

    With the imminent future of the Internet of the Things which implies that everyday objects are connected between them and to the Internet, the need for the development of a software capable of managing communication devices arises. The goal of this thesis was to create a prototype of an Application Programming Interface in the Java language and implement a REST architectural style, capable of managing and authenticating different kinds of information, such as devices and users, as well as...

  3. Analysis of factors affecting angle ANB.

    Science.gov (United States)

    Hussels, W; Nanda, R S

    1984-05-01

    Cephalometric analyses based on angular and linear measurements have obvious fallacies, which have been discussed in detail by Moyers and Bookstein. However, the clinical application of such an analysis by the orthodontic profession in treatment planning is widely accepted. Variations of angle ANB are commonly used to determine relative jaw relationships in most of the cephalometric evaluations. Several authors, including points A and B influences angle ANB, as does rotational growth of the upper and lower jaws. In addition, the authors point out that growth in a vertical direction (distance N to B) and an increase of the dental height (distance A to B) may contribute to changes in angle ANB. For a Class I relation (Wits = 0 mm), a mathematical formula has been developed which enables the authors to study the geometric influence of angle ANB caused by the following four effects: (1) rotation of the jaws and/or occlusal plane relative to the anterior cranial base; (2) anteroposterior position of N relative to point B, (3) vertical growth (distance N to B); (4) increase in dental height (distance A to B). It was observed that, contrary to the common belief that an ANB angle of 2 +/- 3.0 degrees is considered normal for a skeletal Class I relation, the calculated values of angle ANB will vary widely with changes in these four controlling factors under the same skeletal Class I conditions (Wits = 0 mm). Therefore, in a case under consideration, angle ANB must be corrected for these geometric effects in order to get a proper perspective of the skeletal discrepancy. This is facilitated by comparing the measured ANB angle with the corresponding ANB angle calculated by a formula for a Class I relationship. The corresponding calculated angle ANB can be taken from the tables which are based upon the formula using the same values for SNB, omega (angle between occlusal plane and anterior cranial base), b (which is distance N to B) and a (dental height measured as perpendicular

  4. Predictive value of casual ECG-based resting heart rate compared with resting heart rate obtained from Holter recording

    DEFF Research Database (Denmark)

    Carlson, Nicholas; Dixen, Ulrik; Marott, Jacob L;

    2014-01-01

    BACKGROUND: Elevated resting heart rate (RHR) is associated with cardiovascular mortality and morbidity. Assessment of heart rate (HR) from Holter recording may afford a more precise estimate of the effect of RHR on cardiovascular risk, as compared to casual RHR. Comparative analysis was carried ...

  5. Resting-state neuronal oscillatory correlates of working memory performance.

    Directory of Open Access Journals (Sweden)

    David Heister

    Full Text Available PURPOSE: Working memory (WM represents the brain's ability to maintain information in a readily available state for short periods of time. This study examines the resting-state cortical activity patterns that are most associated with performance on a difficult working-memory task. METHODS: Magnetoencephalographic (MEG band-passed (delta/theta (1-7 Hz, alpha (8-13 Hz, beta (14-30 Hz and sensor based regional power was collected in a population of adult men (18-28 yrs, n = 24 in both an eyes-closed and eyes-open resting state. The normalized power within each resting state condition as well as the normalized change in power between eyes closed and open (zECO were correlated with performance on a WM task. The regional and band-limited measures that were most associated with performance were then combined using singular value decomposition (SVD to determine the degree to which zECO power was associated with performance on the three-back verbal WM task. RESULTS: Changes in power from eyes closed to open revealed a significant decrease in power in all band-widths that was most pronounced in the posterior brain regions (delta/theta band. zECO right posterior frontal and parietal cortex delta/theta power were found to be inversely correlated with three-back working memory performance. The SVD evaluation of the most correlated zECO metrics then provided a singular measure that was highly correlated with three-back performance (r = -0.73, p<0.0001. CONCLUSION: Our results indicate that there is an association between WM performance and changes in resting-state power (right posterior frontal and parietal delta/theta power. Moreover, an SVD of the most associated zECO measures produces a composite resting-state metric of regional neural oscillatory power that has an improved association with WM performance. To our knowledge, this is the first investigation that has found that changes in resting state electromagnetic neural patterns are highly

  6. The neural basis of unwanted thoughts during resting state

    OpenAIRE

    Kühn, Simone; Vanderhasselt, Marie-Anne; Raedt, Rudi; Gallinar, J

    2013-01-01

    Human beings are constantly engaged in thought. Sometimes thoughts occur repetitively and can become distressing. Up to now the neural bases of these intrusive or unwanted thoughts is largely unexplored. To study the neural correlates of unwanted thoughts, we acquired resting-state fMRI data of 41 female healthy subjects and assessed the self-reported amount of unwanted thoughts during measurement. We analyzed local connectivity by means of regional homogeneity (ReHo) and functional connectiv...

  7. Regional Patterns of Cortical Phase Synchrony in the Resting State.

    Science.gov (United States)

    Casimo, Kaitlyn; Darvas, Felix; Wander, Jeremiah; Ko, Andrew; Grabowski, Thomas J; Novotny, Edward; Poliakov, Andrew; Ojemann, Jeffrey G; Weaver, Kurt E

    2016-07-01

    Synchronized phase estimates between oscillating neuronal signals at the macroscale level reflect coordinated activities between neuronal assemblies. Recent electrophysiological evidence suggests the presence of significant spontaneous phase synchrony within the resting state. The purpose of this study was to investigate phase synchrony, including directional interactions, in resting state subdural electrocorticographic recordings to better characterize patterns of regional phase interactions across the lateral cortical surface during the resting state. We estimated spontaneous phase locking value (PLV) as a measure of functional connectivity, and phase slope index (PSI) as a measure of pseudo-causal phase interactions, across a broad range of canonical frequency bands and the modulation of the amplitude envelope of high gamma (amHG), a band that is believed to best reflect the physiological processes giving rise to the functional magnetic resonance imaging BOLD signal. Long-distance interactions had higher PLVs in slower frequencies (≤theta) than in higher ones (≥beta) with amHG behaving more like slow frequencies, and a general trend of increasing frequency band of significant PLVs when moving across the lateral surface along an anterior-posterior axis. Moreover, there was a strong trend of frontal-to-parietal directional phase synchronization, measured by PSI across multiple frequencies. These findings, which are likely indicative of coordinated and structured spontaneous cortical interactions, are important in the study of time scales and directional nature of resting state functional connectivity, and may ultimately contribute to a better understanding of how spontaneous synchrony is linked to variation in regional architecture across the lateral cortical surface. PMID:27019319

  8. Dirac Matrices and Feynman’s Rest of the Universe

    Directory of Open Access Journals (Sweden)

    Young S. Kim

    2012-10-01

    Full Text Available There are two sets of four-by-four matrices introduced by Dirac. The first set consists of fifteen Majorana matrices derivable from his four γ matrices. These fifteen matrices can also serve as the generators of the group SL(4, r. The second set consists of ten generators of the Sp(4 group which Dirac derived from two coupled harmonic oscillators. It is shown possible to extend the symmetry of Sp(4 to that of SL(4, r if the area of the phase space of one of the oscillators is allowed to become smaller without a lower limit. While there are no restrictions on the size of phase space in classical mechanics, Feynman’s rest of the universe makes this Sp(4-to-SL(4, r transition possible. The ten generators are for the world where quantum mechanics is valid. The remaining five generators belong to the rest of the universe. It is noted that the groups SL(4, r and Sp(4 are locally isomorphic to the Lorentz groups O(3, 3 and O(3, 2 respectively. This allows us to interpret Feynman’s rest of the universe in terms of space-time symmetry.

  9. Soundscape Ecology of Hawaiian Spinner Dolphin Resting Bays

    Science.gov (United States)

    Heenehan, Heather Leigh

    Sound is a key sensory modality for Hawaiian spinner dolphins. Like many other marine animals, these dolphins rely on sound and their acoustic environment for many aspects of their daily lives, making it is essential to understand soundscape in areas that are critical to their survival. Hawaiian spinner dolphins rest during the day in shallow coastal areas and forage offshore at night. In my dissertation I focus on the soundscape of the bays where Hawaiian spinner dolphins rest taking a soundscape ecology approach. I primarily relied on passive acoustic monitoring using four DSG-Ocean acoustic loggers in four Hawaiian spinner dolphin resting bays on the Kona Coast of Hawai'i Island. 30-second recordings were made every four minutes in each of the bays for 20 to 27 months between January 8, 2011 and March 30, 2013. I also utilized concomitant vessel-based visual surveys in the four bays to provide context for these recordings. In my first chapter I used the contributions of the dolphins to the soundscape to monitor presence in the bays and found the degree of presence varied greatly from less than 40% to nearly 90% of days monitored with dolphins present. Having established these bays as important to the animals, in my second chapter I explored the many components of their resting bay soundscape and evaluated the influence of natural and human events on the soundscape. I characterized the overall soundscape in each of the four bays, used the tsunami event of March 2011 to approximate a natural soundscape and identified all loud daytime outliers. Overall, sound levels were consistently louder at night and quieter during the daytime due to the sounds from snapping shrimp. In fact, peak Hawaiian spinner dolphin resting time co-occurs with the quietest part of the day. However, I also found that humans drastically alter this daytime soundscape with sound from offshore aquaculture, vessel sound and military mid-frequency active sonar. During one recorded mid

  10. Resting Behaviour of Broilers in Three Different Rearing Systems

    OpenAIRE

    Zupan, M.; Berk, J.; Ellendorff, F.; M. Wolf-reuter; Čop, D.; Holcman, A.; Štuhec, I.

    2003-01-01

    The highest number of broilers is reared in the intensive fattening system on the floor with litter. Besides the intensive systems some sustainable rearing ways are also brought forward (ecological, biologic-dynamic, organic, etc.). The aim of this study was to establish the possible differences in resting behaviour of broilers in three rearing systems: intensive on the floor, free range, and organic system. The results showed great varieties between intensive and less intensive systems. In t...

  11. Neuronal Avalanches in the Resting MEG of the Human Brain

    OpenAIRE

    Shriki, Oren; Alstott, Jeff; Carver, Frederick; Holroyd, Tom; Henson, Richard N. A.; Smith, Marie L.; Coppola, Richard; Bullmore, Edward,; Plenz, Dietmar

    2013-01-01

    What constitutes normal cortical dynamics in healthy human subjects is a major question in systems neuroscience. Numerous in vitro and in vivo animal studies have shown that ongoing or resting cortical dynamics are characterized by cascades of activity across many spatial scales, termed neuronal avalanches. In experiment and theory, avalanche dynamics are identified by two measures: (1) a power law in the size distribution of activity cascades with an exponent of −3/2 and (2) a branching para...

  12. A lattice determination of gA and left angle x right angle from overlap fermions

    International Nuclear Information System (INIS)

    We present results for the nucleon's axial charge gA and the first moment left angle x right angle of the unpolarized parton distribution function from a simulation of quenched overlap fermions. (orig.)

  13. Analysis of reaction Ξ- at rest by AMD-QL

    International Nuclear Information System (INIS)

    The reaction Ξ- at rest is one of the most effective reactions to produce double-hyper nucleus by use of the elementary reaction: Ξ- + p → Λ + Λ + 28.3 MeV. This work investigated the production rate of double-hyper nucleus and the dependency to the target nucleus by analyzing the reactions Ξ- at rest with the target nucleus of 9Be, 12C and 14N by AMD-QL (antisymmetric molecular dynamics-quantum mechanical Langevin method), the simulation theory of the quantum statistic mechanics for fluctuation. We applied AMD-QL to the reaction: 55 MeV p + 12C. The results showed that this method improved description of dynamic spallation process, which produced light fragments in the course of pre-equilibrium process until 200 fm/c of AMD-QL. The reaction Ξ- at rest with 9Be, 12C and 14N-target nucleus was simulated by AMD-QL + cascade. The total production rate of double-hyper nucleus increased with increasing the mass number of target nucleus. When 9Be was the target nucleus, the production rate of ΛΛ6He increased to 3.6%. (S.Y.)

  14. Compression failure of angle-ply laminates

    OpenAIRE

    Peel, Larry D

    1991-01-01

    The present work deals with modes and mechanisms of failure in compression of angleply laminates. Experimental results were obtained from 42 angle-ply IM7/8551-7a specimens with a lay-up of [ (±9) / (=F9)] 6s where 9, the off-axis angle, ranged from 0° to 90°. The results showed four failure modes, these modes being a function of off-axis angle. Failure modes include fiber compression, inplane transverse tension, inplane shear, and inplane transverse compression. Excessive inte...

  15. Gender Differences in Bed Rest: Preliminary Analysis of Vascular Function

    Science.gov (United States)

    Platts, Steven H.; Stenger, Michael B.; Martin, David S.; Freeman-Perez, Sondra A.; Phillips, Tiffany; Ribeiro, L. Christine

    2008-01-01

    Orthostatic intolerance is a recognized consequence of spaceflight. Numerous studies have shown that women are more susceptible to orthostatic intolerance following spaceflight as well as bed rest, the most commonly used ground-based analog for spaceflight. One of the possible mechanisms proposed to account for this is a difference in vascular responsiveness between genders. We hypothesized that women and men would have differing vascular responses to 90 days of 6-degree head down tilt bed rest. Additionally, we hypothesized that vessels in the upper and lower body would respond differently, as has been shown in the animal literature. Thirteen subjects were placed in bedrest for 90 days (8 men, 5 women) at the Flight Analogs Unit, UTMB. Direct arterial and venous measurements were made with ultrasound to evaluate changes in vascular structure and function. Arterial function was assessed, in the arm and leg, during a reactive hyperemia protocol and during sublingual nitroglycerin administration to gauge the contributions of endothelial dependent and independent dilator function respectively. Venous function was assessed in dorsal hand and foot veins during the administration of pharmaceuticals to assess constrictor and dilator function. Both gender and day effects are seen in arterial dilator function to reactive hyperemia, but none are seen with nitroglycerin. There are also differences in the wall thickness in the arm vs the leg during bed rest, which return toward pre-bed rest levels by day 90. More subjects are required, especially females as there is not sufficient power to properly analyze venous function. Day 90 data are most underpowered.

  16. Nonadiabatic Hannay's Angle of Spin One Half in Grassmannian Version and Invariant Angle Coherent States

    OpenAIRE

    Cherbal, Omar; Maamache, Mustapha; Drir, Mahrez

    2003-01-01

    We propose to determinate the nonadiabatic Hannay’s angle of spin one half in a varying external magnetic field, by using an averaged version of the variational principal. We also show how the evolution and this nonadiabatic Hannay’s angle is associated with the evolution of Grassmannian invariant-angle coherent states.

  17. EMERGENCE ANGLE OF FLOW OVER AN AERATOR

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Aerator is an important device for release works of hydraulic structures with high-speed flow in order to protect them from cavitation damage. This kind of protecting effect is related closely to cavity length below the aerator, while the cavity length is dominated by the emergence angle over the aerator. Therefore it is crucial to determine this angle accurately. In the present paper the affecting intensities of flow depth and the fluctuating velocity on this angle were analyzed through two introduced parameters. Furthermore, the improved expressions of emergence angle estimation, for both ramp-type and step-type aerators, were presented by means of 68 sets of experimental data from 6 projects based on error theory. The results showed that the present method has higher accuracy than the previously reported methods.

  18. Viewing angle analysis of integral imaging

    Science.gov (United States)

    Wang, Hong-Xia; Wu, Chun-Hong; Yang, Yang; Zhang, Lan

    2007-12-01

    Integral imaging (II) is a technique capable of displaying 3D images with continuous parallax in full natural color. It is becoming the most perspective technique in developing next generation three-dimensional TV (3DTV) and visualization field due to its outstanding advantages. However, most of conventional integral images are restricted by its narrow viewing angle. One reason is that the range in which a reconstructed integral image can be displayed with consistent parallax is limited. The other is that the aperture of system is finite. By far many methods , an integral imaging method to enhance the viewing angle of integral images has been proposed. Nevertheless, except Ren's MVW (Maximum Viewing Width) most of these methods involve complex hardware and modifications of optical system, which usually bring other disadvantages and make operation more difficult. At the same time the cost of these systems should be higher. In order to simplify optical systems, this paper systematically analyzes the viewing angle of traditional integral images instead of modified ones. Simultaneously for the sake of cost the research was based on computer generated integral images (CGII). With the analysis result we can know clearly how the viewing angle can be enhanced and how the image overlap or image flipping can be avoided. The result also promotes the development of optical instruments. Based on theoretical analysis, preliminary calculation was done to demonstrate how the other viewing properties which are closely related with the viewing angle, such as viewing distance, viewing zone, lens pitch, and etc. affect the viewing angle.

  19. The Role of the CoREST/REST Repressor Complex in Herpes Simplex Virus 1 Productive Infection and in Latency

    Directory of Open Access Journals (Sweden)

    Bernard Roizman

    2013-04-01

    Full Text Available REST is a key component of the HDAC1 or 2, CoREST, LSD1, REST (HCLR repressor complex. The primary function of the HCLR complex is to silence neuronal genes in non-neuronal cells. HCLR plays a role in regulating the expression of viral genes in productive infections as a donor of LDS1 for expression of α genes and as a repressor of genes expressed later in infection. In sensory neurons the HCLR complex is involved in the silencing of viral genome in the course of establishment of latency. The thesis of this article is that (a sensory neurons evolved a mechanism to respond to the presence and suppress the transmission of infectious agents from the periphery to the CNS and (b HSV evolved subservience to the HCLR with at least two objectives: to maintain a level of replication consistent with maximal person-to-person spread and to enable it to take advantage of neuronal innate immune responses to survive and be available for reactivation shielded from adaptive immune responses of the host.

  20. REST based mobile applications

    Science.gov (United States)

    Rambow, Mark; Preuss, Thomas; Berdux, Jörg; Conrad, Marc

    2008-02-01

    Simplicity is the major advantage of REST based webservices. Whereas SOAP is widespread in complex, security sensitive business-to-business aplications, REST is widely used for mashups and end-user centric applicatons. In that context we give an overview of REST and compare it to SOAP. Furthermore we apply the GeoDrawing application as an example for REST based mobile applications and emphasize on pros and cons for the use of REST in mobile application scenarios.

  1. Resting state networks and consciousness Alterations of multiple resting state network connectivity in physiological, pharmacological and pathological consciousness states

    OpenAIRE

    Heine, Lizette; Soddu, Andrea; Gomez Jaramillo, Francisco Albeiro(*); Vanhaudenhuyse, Audrey; Tshibanda, Luaba; Thonnard, Marie; Charland-Verville, Vanessa; Kirsch, Murielle; Laureys, Steven; Demertzi, Athina

    2012-01-01

    In order to better understand the functional contribution of resting state activity to conscious cognition, we aimed to review increases and decreases in fMRI functional connectivity under physiological (sleep), pharmacological (anesthesia) and pathological altered states of consciousness, such as brain death, coma, vegetative state/unresponsive wakefulness syndrome, and minimally conscious state. The reviewed RSNs were the DMN, left and right executive control, salience, sensorimotor, audito...

  2. Same day injections of Tc-99m methoxy isobutyl isonitrile (hexamibi) for myocardial tomographic imaging: Comparison between rest-stress and stress-rest injection sequences

    International Nuclear Information System (INIS)

    It has been shown that both rest and stress 99mTc-hexamibi myocardial perfusion imaging can be performed on the same day using two different doses injected within few h (the first one at rest followed by a second at stress). In order to evaluate and compare 2 sequences (rest-stress and stress-rest) of 99mTc-hexamibi injections performed the same day, 18 patients with either abnormal 201Tl myocardial scan or abnormal coronary angiography were studied with 2 99mTc-hexamibi injections protocols. The rest-stress study was performed as follows: 7 mCi 99mTc-hexamibi was injected at rest. Single photon emission computed tomography (SPECT) was performed 60 min later. Immediately after the rest study, patients were injected at peak stress with 25 mCi 99mTc-hexamibi. Tomographic imaging was repeated 1 h later. Patients were submitted to the stress-rest protocol within 3 days. Tomographic imaging was done 1 h after a 7 mCi injection at stress. This study was followed by an injection of 25 mCi 99mTc-hexamibi at rest, a tomographic study was performed 60 min later. Myocardial sections were reconstructed in horizontal long, vertical long, and short axes. Data analysis also included polar map representation. A total of 324 segments were interpreted blind by 3 observers, there was an agreement in 283/324 (87.3%) segments between the 2 protocols. However, 24 segments (7.4%) judged ischemic on rest-stress were called scars on stress-rest. In three patients, myocardial segments were judged normal on the rest image of the rest-stress protocol while they were found abnormal (false positive images) on the stress-rest sequence. Stress images from both protocols were judged similar in 17 patients. In conclusion, when using a short time interval (less than 2 h) between two 99mTc-hexamibi injections, it is preferable to do a rest-stress sequence since the rest image performed initially represents a true rest study, which is not necessarily the case with the stress-rest sequence. (orig.)

  3. Radon - an angle of view

    International Nuclear Information System (INIS)

    Apart from its radiation effects on living organism, radon induces the formation of atmospheric ions which are beneficial to man: some asthmatics can breathe more easily in an environment with elevated ion levels, the blood pH increases, the fraction of albumins is higher while the serotonin level is lower, sedimentation decreases and the leukocyte counts in peripherals diminish. The blood pressure, particularly in people suffering from hypertension, drops appreciably. The production of pituitary hormones as well as the overall sexual activity is stimulated by ions in air. Exposure to negative ions affects circulation through the skin, reduces skin temperature and improves overall resistance of the organism to infection. Negative ions also have a stimulating effect on mental activity and help against insomnia. Sites where radon is present in not too high concentrations are often famous as climatic spas. So, antiradon provisions, if exercised too thoroughly, may have adverse rather than positive consequences. All pros and cons should always be taken into account when deciding on antiradon steps. (P.A.)

  4. Precision measurements of the CKM angle gamma

    CERN Document Server

    CERN. Geneva

    2016-01-01

    The level of CP-violation permitted within the Standard Model cannot account for the matter dominated universe in which we live. Within the Standard Model the CKM matrix, which describes the quark couplings, is expected to be unitary. By making precise measurements of the CKM matrix parameters new physics models can be constrained, or with sufficient precision the effects of physics beyond the standard model might become apparent. The CKM angle gamma is the least well known angle of the unitarity triangle. It is the only angle easily accessible at tree-level, and furthermore has almost no theoretical uncertainties. Therefore it provides an invaluable Standard Model benchmark against which other new physics sensitive tests of the CP-violation can be made. I will discuss recent measurements of gamma using the the Run 1 LHCb dataset, which improve our knowledge of this key parameter.

  5. Low-dimensional dynamics of resting-state cortical activity.

    Science.gov (United States)

    Mehrkanoon, Saeid; Breakspear, Michael; Boonstra, Tjeerd W

    2014-05-01

    Endogenous brain activity supports spontaneous human thought and shapes perception and behavior. Connectivity-based analyses of endogenous, or resting-state, functional magnetic resonance imaging (fMRI) data have revealed the existence of a small number of robust networks which have a rich spatial structure. Yet the temporal information within fMRI data is limited, motivating the complementary analysis of electrophysiological recordings such as electroencephalography (EEG). Here we provide a novel method based on multivariate time-frequency interdependence to reconstruct the principal resting-state network dynamics in human EEG data. The stability of network expression across subjects is assessed using resampling techniques. We report the presence of seven robust networks, with distinct topographic organizations and high frequency (∼ 5-45 Hz) fingerprints, nested within slow temporal sequences that build up and decay over several orders of magnitude. Interestingly, all seven networks are expressed concurrently during these slow dynamics, although there is a temporal asymmetry in the pattern of their formation and dissolution. These analyses uncover the complex temporal character of endogenous cortical fluctuations and, in particular, offer an opportunity to reconstruct the low dimensional linear subspace in which they unfold. PMID:24104726

  6. An experimental test of the ability of Daphnia galeata resting egg production in Lake Biwa

    Directory of Open Access Journals (Sweden)

    Narumi K. Tsugeki

    2014-02-01

    Full Text Available The Daphnia galeata population in Lake Biwa (Japan had almost ceased producing resting eggs by the 1980s. To examine whether D. galeata had lost the ability to produce resting eggs, or if chemical contamination was inhibiting resting egg production, individuals collected in fall (November and late winter (March, were reared in the laboratory. More than 50% of these D. galeata individuals produced resting eggs irrespective of the month of collection, when reared with food supplied at a level lower than that available during the maternal generation. The results reflect that D. galeata in Lake Biwa have a high ability to produce resting eggs when appropriate stimuli are provided. As chemical substances, such as endocrine disrupters, are known to inhibit resting egg production in Daphnia and these accumulate in lake sediments, we tested whether Daphnia individuals produce resting eggs when reared in sediment-conditioned lake water. In sediment-conditioned lake water, only a few Daphnia that were collected in March produced resting eggs, while 50% of the individuals collected in November produced resting eggs. Thus, D. galeata collected from Lake Biwa are able to produce resting eggs, but genetic variation likely leads to variation in resting egg production in the presence of chemical contaminants. These results suggest that the recent decrease in the resting egg production of Daphnia populations in lake Biwa is mainly due to a decrease in the strength of the environmental queue that stimulates resting egg production rather than a genetic shift to strains that have a lower ability to produce resting eggs; yet, we cannot rule out the possibility that a chemical contamination plays a role in the decrease of resting egg production.

  7. Angle-Resolved Spectroscopy of Parametric Fluorescence

    CERN Document Server

    Hsu, Feng-kuo

    2013-01-01

    The parametric fluorescence from a nonlinear crystal forms a conical radiation pattern. We measure the angular and spectral distributions of parametric fluorescence in a beta-barium borate crystal pumped by a 405-nm diode laser employing angle-resolved imaging spectroscopy. The experimental angle-resolved spectra and the generation efficiency of parametric down conversion are compared with a plane-wave theoretical analysis. The parametric fluorescence is used as a broadband light source for the calibration of the instrument spectral response function in the wavelength range from 450 to 1000 nm.

  8. Longitudinal Changes of Angle Configuration in Primary Angle-Closure Suspects

    Science.gov (United States)

    Jiang, Yuzhen; Chang, Dolly S.; Zhu, Haogang; Khawaja, Anthony P.; Aung, Tin; Huang, Shengsong; Chen, Qianyun; Munoz, Beatriz; Grossi, Carlota M.

    2015-01-01

    Objective To determine longitudinal changes in angle configuration in the eyes of primary angle-closure suspects (PACS) treated by laser peripheral iridotomy (LPI) and in untreated fellow eyes. Design Longitudinal cohort study. Participants Primary angle-closure suspects aged 50 to 70 years were enrolled in a randomized, controlled clinical trial. Methods Each participant was treated by LPI in 1 randomly selected eye, with the fellow eye serving as a control. Angle width was assessed in a masked fashion using gonioscopy and anterior segment optical coherence tomography (AS-OCT) before and at 2 weeks, 6 months, and 18 months after LPI. Main Outcome Measures Angle width in degrees was calculated from Shaffer grades assessed under static gonioscopy. Angle configuration was also evaluated using angle opening distance (AOD250, AOD500, AOD750), trabecular-iris space area (TISA500, TISA750), and angle recess area (ARA) measured in AS-OCT images. Results No significant difference was found in baseline measures of angle configuration between treated and untreated eyes. At 2 weeks after LPI, the drainage angle on gonioscopy widened from a mean of 13.5° at baseline to a mean of 25.7° in treated eyes, which was also confirmed by significant increases in all AS-OCT angle width measures (P<0.001 for all variables). Between 2 weeks and 18 months after LPI, a significant decrease in angle width was observed over time in treated eyes (P<0.001 for all variables), although the change over the first 5.5 months was not statistically significant for angle width measured under gonioscopy (P = 0.18), AOD250 (P = 0.167) and ARA (P = 0.83). In untreated eyes, angle width consistently decreased across all follow-up visits after LPI, with a more rapid longitudinal decrease compared with treated eyes (P values for all variables ≤0.003). The annual rate of change in angle width was equivalent to 1.2°/year (95% confidence interval [CI], 0.8–1.6) in treated eyes and 1.6°/year (95% CI, 1

  9. Expanded functional coupling of subcortical nuclei with the motor resting-state network in multiple sclerosis

    DEFF Research Database (Denmark)

    Dogonowski, Anne-Marie; Siebner, Hartwig R; Sørensen, Per Soelberg;

    2013-01-01

    matched controls underwent a 20-minute resting-state fMRI session at 3 Tesla. Independent component analysis was applied to the fMRI data to identify disease-related changes in motor resting-state connectivity. RESULTS: Patients with MS showed a spatial expansion of motor resting-state connectivity in...

  10. Exercise-induced pyruvate dehydrogenase activation is not affected by 7 days of bed rest

    DEFF Research Database (Denmark)

    Kiilerich, Kristian; Jørgensen, Stine Ringholm; Biensø, Rasmus Sjørup;

    2011-01-01

    after bed rest than before, indicating glucose intolerance. There were no differences in lactate release/uptake across the exercising muscle before and after bed rest, but glucose uptake after 40min of exercise was larger (P=0.05) before bed rest than after. Muscle glycogen content tended to be higher...

  11. On Dihedral Angles of a Simplex

    OpenAIRE

    Maehara, H.

    2013-01-01

    For an $n$-simplex, let $\\alpha,\\,\\beta$ denote the maximum, and the minimum dihedral angles of the simplex, respectively. It is proved that the inequality $\\alpha\\le \\arccos(1/n)\\le \\beta$ always holds, and either side equality implies that the $n$-simplex is a regular simplex. Similar inequalities are also given for a star-simplex, which is defined as a simplex that has a vertex (apex) such that the angles between distinct edges incident to the apex are all equal. Further, an explicit formu...

  12. Status of the CDF small angle spectrometer

    International Nuclear Information System (INIS)

    During the 1987 Tevatron collider period the CDF small angle spectrometer system was partially installed and elastic scattering events were recorded in a special high-β run. The design and physics goals of this system are described and results from an analysis of the elastic scattering data are discussed

  13. The physical interpretation of mass as rest-frame frequency

    International Nuclear Information System (INIS)

    It is shown that, if one regards particles as spatially extended periodic disturbances in a classical background field, with a simple interaction in which charged particles are modulated by photons, then the angular frequency of a free-particle disturbance in its rest frame has the inertial property required of mass. Quantitative development of this picture provides a unified derivation, on the one hand, of classical equations of motion such as Newton's Second Law and the Lorentz force and, on the other, of the Dirac and Schroedinger equations for a particle in a potential. Some remarks are made on the problem of establishing the other key property of mass, namely its additivity, within this approach. 1 fig

  14. One of us: Stories from two New Zealand rest homes.

    Science.gov (United States)

    Jaye, Chrystal; Hale, Beatrice; Butler, Mary; McKechnie, Roz; Robertson, Linda; Simpson, Jean; Tordoff, June; Young, Jessica

    2015-12-01

    In this article we explore the ways in which two aged residential care facilities in New Zealand construct and present themselves through the stories told by those who live and work in them. Ethnographic field notes and interviews were analysed using an immersion/crystallization method consistent with a narrative gerontology framework. Woven into residents' stories about their lives in the facility were tales of earlier lives and identities, immigration, occupations, marriage, tragedies and medical emergencies. Care workers, nursing staff and managers talked about vocation, the ethos and values of the institution and the importance that both staff and residents felt a sense of belonging and 'being one of us.' These stories, 'talk into reality' the aged residential care facility as a particular kind of rest home, in which residents feel 'at home'. In addition, as researchers who brought our own stories to the project, we actively contributed to the construction of each institution as a certain kind of facility. PMID:26568223

  15. Experimental technique of small angle neutron scattering

    International Nuclear Information System (INIS)

    The main parts of Small Angle Neutron Scattering (SANS) spectrometer, and their function and different parameters are introduced from experimental aspect. Detailed information is also introduced for SANS spectrometer 'Membrana-2'. Based on practical experiments, the fundamental requirements and working condition for SANS experiments, including sample preparation, detector calibration, standard sample selection and data preliminary process are described. (authors)

  16. Graph theoretical analysis of resting magnetoencephalographic functional connectivity networks

    Directory of Open Access Journals (Sweden)

    Lindsay eRutter

    2013-07-01

    Full Text Available Complex networks have been observed to comprise small-world properties, believed to represent an optimal organization of local specialization and global integration of information processing at reduced wiring cost. Here, we applied magnitude squared coherence to resting magnetoencephalographic time series in reconstructed source space, acquired from controls and patients with schizophrenia, and generated frequency-dependent adjacency matrices modeling functional connectivity between virtual channels. After configuring undirected binary and weighted graphs, we found that all human networks demonstrated highly localized clustering and short characteristic path lengths. The most conservatively thresholded networks showed efficient wiring, with topographical distance between connected vertices amounting to one-third as observed in surrogate randomized topologies. Nodal degrees of the human networks conformed to a heavy-tailed exponentially truncated power-law, compatible with the existence of hubs, which included theta and alpha bilateral cerebellar tonsil, beta and gamma bilateral posterior cingulate, and bilateral thalamus across all frequencies. We conclude that all networks showed small-worldness, minimal physical connection distance, and skewed degree distributions characteristic of physically-embedded networks, and that these calculations derived from graph theoretical mathematics did not quantifiably distinguish between subject populations, independent of bandwidth. However, post-hoc measurements of edge computations at the scale of the individual vertex revealed trends of reduced gamma connectivity across the posterior medial parietal cortex in patients, an observation consistent with our prior resting activation study that found significant reduction of synthetic aperture magnetometry gamma power across similar regions. The basis of these small differences remains unclear.

  17. Plasticity of resting state brain networks in recovery from stress

    Directory of Open Access Journals (Sweden)

    Jose Miguel Soares

    2013-12-01

    Full Text Available Chronic stress has been widely reported to have deleterious impact in multiple biological systems. Specifically, structural and functional remodelling of several brain regions following prolonged stress exposure have been described; importantly, some of these changes are eventually reversible. Recently, we showed the impact of stress on resting state networks (RSNs, but nothing is known about the plasticity of RSNs after recovery from stress. Herein, we examined the plasticity of RSNs, both at functional and structural levels, by comparing the same individuals before and after recovery from the exposure to chronic stress; results were also contrasted with a control group. Here we show that the stressed individuals after recovery displayed a decreased resting functional connectivity in the default mode network (DMN, ventral attention network (VAN and sensorimotor network (SMN when compared to themselves immediately after stress; however, this functional plastic recovery was only partial as when compared with the control group, as there were still areas of increased connectivity in dorsal attention network (DAN, SMN and primary visual network (VN in participants recovered from stress. Data also shows that participants after recovery from stress displayed increased deactivations in DMN, SMN and auditory network (AN, to levels similar to those of controls, showing a normalization of the deactivation pattern in RSNs after recovery from stress. In contrast, structural changes (volumetry of the brain areas involving these networks are absent after the recovery period. These results reveal plastic phenomena in specific RSNs and a functional remodeling of the activation-deactivation pattern following recovery from chronic-stress, which is not accompanied by significant structural plasticity.

  18. Determinants of resting cerebral blood flow in sickle cell disease.

    Science.gov (United States)

    Bush, Adam M; Borzage, Matthew T; Choi, Soyoung; Václavů, Lena; Tamrazi, Benita; Nederveen, Aart J; Coates, Thomas D; Wood, John C

    2016-09-01

    Stroke is common in children with sickle cell disease and results from an imbalance in oxygen supply and demand. Cerebral blood flow (CBF) is increased in patients with sickle cell disease to compensate for their anemia, but adequacy of their oxygen delivery has not been systematically demonstrated. This study examined the physiological determinants of CBF in 37 patients with sickle cell disease, 38 ethnicity matched control subjects and 16 patients with anemia of non-sickle origin. Cerebral blood flow was measured using phase contrast MRI of the carotid and vertebral arteries. CBF increased inversely to oxygen content (r(2)  = 0.69, P Brain oxygen delivery, the product of CBF and oxygen content, was normal in all groups. Brain composition, specifically the relative amounts of grey and white matter, was the next strongest CBF predictor, presumably by influencing cerebral metabolic rate. Grey matter/white matter ratio and CBF declined monotonically until the age of 25 in all subjects, consistent with known maturational changes in brain composition. Further CBF reductions were observed with age in subjects older than 35 years of age, likely reflecting microvascular aging. On multivariate regression, CBF was independent of disease state, hemoglobin S, hemoglobin F, reticulocyte count and cell free hemoglobin, suggesting that it is regulated similarly in patients and control subjects. In conclusion, sickle cell disease patients had sufficient oxygen delivery at rest, but accomplish this only by marked increases in their resting CBF, potentially limiting their ability to further augment flow in response to stress. Am. J. Hematol. 91:912-917, 2016. © 2016 Wiley Periodicals, Inc. PMID:27263497

  19. A fringe shadow method for measuring flapping angle and torsional angle of a dragonfly wing

    Science.gov (United States)

    Zeng, Lijiang; Matsumoto, Hirokazu; Kawachi, Keiji

    1996-05-01

    A fringe shadow (FS) method was developed for measuring the flapping angle and torsional angle of a dragonfly wing during beating motion. This new method involves two sets of fringe patterns projected onto the wing from orthogonal directions. The torsional angle is determined using the length of the shadow of the wing chord that is cast by the two sets of fringe patterns. The flapping angle is determined using the shadowgraph of the wing projected by a laser. The advantages of the FS method are its capability (i) to measure the flapping angle and torsional angle of a dragonfly wing simultaneously using only one high-speed camera and (ii) to recognize the spanwise position of a section from the number of fringes, without having to use diffuse marks that are common in current methods. The resolution of the FS method can be changed easily by adjusting the fringe spacing. The measurement results for the torsional angle and flapping angle of a dragonfly wing prove the effectiveness of the FS method in studying the flight performance of dragonflies.

  20. Biomarkers of Dose and Effect of inhaled ozone in resting versus exercising human subjects: comparison with resting rats

    Science.gov (United States)

    Background: Human controlled exposure studies have generally focused on subjects exposed to ozone (O3) while exercising while exposures in rats have been done at rest. We exposed resting subjects to labeled O3 (18O3, 0.4 ppm, for 2 hr) and compared O3 dose and effects with our...

  1. Performance Evaluation of RESTful Web Services for Mobile Devices

    OpenAIRE

    Hatem Hamad; Motaz Saad; Ramzi Abed

    2010-01-01

    Smart Mobile devices and web services are becoming very popular. Mobile devices are physically constraineddevices; low processor speed, limited memory, limited battery, and slow intermit wireless connection. This implies to take inconsideration these factors when implementing web services for mobile devices. In this paper, we evaluate the RESTful webservice for mobile devices against conventional SOAP web services. The experimental results show that RESTful web servicesoutperform conventional...

  2. Effect of 14 days of bed rest on urine metabolite excretion and plasma enzyme levels

    Science.gov (United States)

    Pace, N.; Grunbaum, B. W.; Kodama, A. M.; Rahlmann, D. F.; Newsom, B. D.

    1974-01-01

    After 1 week of ambulatory base-line measurement, a group of 8 men 19-26 years of age remained continuously recumbent for 14 days. Studies were continued for 1 week following the prolonged recumbency. Urine excretion rates for a number of constituents were determined 2 days before bed rest, on day 14 of bed rest, and day 6 after bed rest. Blood plasma samples were also obtained at these times, and analyzed for several enzymes. On day 14 of bed rest significant increases were observed in urine excretion of total osmotically-active substances, magnesium, calcium, phosphate, creatinine, hydroxyproline, and 17-OH corticosteroids. A decrease occurred in urinary glucose excretion. Plasma levels of alkaline phosphatase and LDH-3 were depressed, while plasma GPT was elevated. Many of these changes persisted on day 6 after bed rest, and are interpreted as concomitants of the disuse atrophy of the musculoskeletal system that characterizes prolonged bed rest and weightlessness.

  3. Cognitive models for the concept of angle

    OpenAIRE

    Matos, José Manuel Leonardo de

    1999-01-01

    The instructional models taught in class were similar to the students' models. The teachers addressed angle as a basic-level category, discussed its submodels, clarified the boundaries, and established cognitive reference points. They gradually increased the use of complex metaphors and of several models. The study enriched the characterization of the first two levels of van Hiele theory and demonstrated the value of categorization theory in understanding how our comprehension ...

  4. Resting position of the head and malocclusion in a group of patients with cerebral palsy

    OpenAIRE

    Martinez-Mihi, Victoria; Silvestre, Francisco J.; Orellana, Lorena M.; Silvestre-Rangil, Javier

    2014-01-01

    Cerebral palsy are found as a result of these disorders, along with associated neuromuscular functional alterations that affect the resting position of the head. In this context, the resting position of the head could be responsible for several skeletal and dental occlusal disorders among patients with cerebral palsy. Objective: To assess the presence of malocclusions in patients with cerebral palsy, define the most frequent types of malocclusions, and evaluate how the resting position of the...

  5. Resting position of the head and malocclusion in a group of patients with cerebral palsyn

    OpenAIRE

    Martínez Mihi, Victoria; Silvestre Donat, Francisco Javier; Orellana, Lorena Mirtala; Silvestre Rangil, Javier

    2014-01-01

    Cerebral palsy are found as a result of these disorders, along with associated neuromuscular functional alterations that affect the resting position of the head. In this context, the resting position of the head could be responsible for several skeletal and dental occlusal disorders among patients with cerebral palsy. Objective: To assess the presence of malocclusions in patients with cerebral palsy, define the most frequent types of malocclusions, and evaluate how the resting pos...

  6. Perceptions of tilt angles of an agricultural tractor.

    Science.gov (United States)

    Görücü, Serap; Cavallo, Eugenio; Murphy, Dennis

    2014-01-01

    A tractor stability simulator has been developed to help study tractor operators' perceptions of angles when the simulator is tilted to the side. The simulator is a trailer-mounted tractor cab equipped with hydraulic lift that can tilt the tractor cabin up to 30 degrees. This paper summarizes data from 82 participants who sat in the simulator while it was tilted. Demographic variables, estimates of tilt angles, and measured tilt angles were collected. The effects of age, gender, tractor driving experience, and frequency of operation on the estimated and measured tilt angles were analyzed. The results showed that about 50% of the participants reported estimations of side tilt angles within ±5 degrees of the actual angles, and nearly the same percentage overestimated the actual side tilt angles. Only a small percentage underestimated the angles. Older, more experienced, and male participants set higher limits on the actual angle at which they felt uncomfortable and would not drive. PMID:24417527

  7. The effect of inter-set rest intervals on resistance exercise-induced muscle hypertrophy.

    Science.gov (United States)

    Henselmans, Menno; Schoenfeld, Brad J

    2014-12-01

    Due to a scarcity of longitudinal trials directly measuring changes in muscle girth, previous recommendations for inter-set rest intervals in resistance training programs designed to stimulate muscular hypertrophy were primarily based on the post-exercise endocrinological response and other mechanisms theoretically related to muscle growth. New research regarding the effects of inter-set rest interval manipulation on resistance training-induced muscular hypertrophy is reviewed here to evaluate current practices and provide directions for future research. Of the studies measuring long-term muscle hypertrophy in groups employing different rest intervals, none have found superior muscle growth in the shorter compared with the longer rest interval group and one study has found the opposite. Rest intervals less than 1 minute can result in acute increases in serum growth hormone levels and these rest intervals also decrease the serum testosterone to cortisol ratio. Long-term adaptations may abate the post-exercise endocrinological response and the relationship between the transient change in hormonal production and chronic muscular hypertrophy is highly contentious and appears to be weak. The relationship between the rest interval-mediated effect on immune system response, muscle damage, metabolic stress, or energy production capacity and muscle hypertrophy is still ambiguous and largely theoretical. In conclusion, the literature does not support the hypothesis that training for muscle hypertrophy requires shorter rest intervals than training for strength development or that predetermined rest intervals are preferable to auto-regulated rest periods in this regard. PMID:25047853

  8. I am resting but rest less well with you. The Moderating Effect of Anxious Attachment Style on Alpha Power during EEG Resting State in a Social Context

    Directory of Open Access Journals (Sweden)

    Willem J.M.I. Verbeke

    2014-07-01

    Full Text Available We took EEG recordings to measure task-free resting-state cortical brain activity in 35 participants under two conditions, alone (A or together (T. We also investigated whether psychological attachment styles shape human cortical activity differently in these two settings. The results indicate that social context matters and that participants’ cortical activity is moderated by the anxious, but not avoidant attachment style. We found enhanced alpha, beta and theta band activity in the T rather than the A resting-state condition, which was more pronounced in posterior brain regions. We further found a positive correlation between anxious attachment style and enhanced alpha power in the T versus A condition over frontal and parietal scalp regions. There was no significant correlation between the absolute powers registered in the other two frequency bands and the participants’ anxious attachment style.

  9. Influence of ROI selection on Resting Functional Connectivity: An Individualized Approach for Resting fMRI Analysis

    Directory of Open Access Journals (Sweden)

    William Seunghyun Sohn

    2015-08-01

    Full Text Available The differences in how our brain is connected are often thought to reflect the differences in our individual personalities and cognitive abilities. Individual differences in brain connectivity has long been recognized in the neuroscience community however it has yet to manifest itself in the methodology of resting state analysis. This is evident as previous studies use the same region of interest (ROIs for all subjects. In this paper we demonstrate that the use of ROIs which are standardized across individuals leads to inaccurate calculations of functional connectivity. We also show that this problem can be addressed by taking an individualized approach by using subject-specific ROIs. Finally we show that ROI selection can affect the way we interpret our data by showing different changes in functional connectivity with ageing.

  10. The constancy of the contact angle in viscous liquid motions with pinned contact lines

    Indian Academy of Sciences (India)

    P N Shankar; R Kidambi

    2005-07-01

    Consider motion initiated in a viscous liquid in a smooth walled container. The liquid is initially at rest under uniform pressure from an inert gas of negligible inertia. We show that if the contact line is pinned and the interface is single valued, the contact angle has to remain constant throughout the motion. This is true even for motions of finite amplitude. Some implications of the result are discussed.

  11. The neural basis of unwanted thoughts during resting state.

    Science.gov (United States)

    Kühn, Simone; Vanderhasselt, Marie-Anne; De Raedt, Rudi; Gallinat, Jürgen

    2014-09-01

    Human beings are constantly engaged in thought. Sometimes thoughts occur repetitively and can become distressing. Up to now the neural bases of these intrusive or unwanted thoughts is largely unexplored. To study the neural correlates of unwanted thoughts, we acquired resting-state fMRI data of 41 female healthy subjects and assessed the self-reported amount of unwanted thoughts during measurement. We analyzed local connectivity by means of regional homogeneity (ReHo) and functional connectivity of a seed region. More unwanted thoughts (state) were associated with lower ReHo in right dorsolateral prefrontal cortex (DLPFC) and higher ReHo in left striatum (putamen). Additional seed-based analysis revealed higher functional connectivity of the left striatum with left inferior frontal gyrus (IFG) in participants reporting more unwanted thoughts. The state-dependent higher connectivty in left striatum was positively correlated with rumination assessed with a dedicated questionnaire focussing on trait aspects. Unwanted thoughts are associated with activity in the fronto-striatal brain circuitry. The reduction of local connectivity in DLPFC could reflect deficiencies in thought suppression processes, whereas the hightened activity in left striatum could imply an imbalance of gating mechanisms housed in basal ganglia. Its functional connectivity to left IFG is discussed as the result of thought-related speech processes. PMID:23929943

  12. Intensive reasoning training alters patterns of brain connectivity at rest.

    Science.gov (United States)

    Mackey, Allyson P; Miller Singley, Alison T; Bunge, Silvia A

    2013-03-13

    Patterns of correlated activity among brain regions reflect functionally relevant networks that are widely assumed to be stable over time. We hypothesized that if these correlations reflect the prior history of coactivation of brain regions, then a marked shift in cognition could alter the strength of coupling between these regions. We sought to test whether intensive reasoning training in humans would result in tighter coupling among regions in the lateral frontoparietal network, as measured with resting-state fMRI (rs-fMRI). Rather than designing an artificial training program, we studied individuals who were preparing for a standardized test that places heavy demands on relational reasoning, the Law School Admissions Test (LSAT). LSAT questions require test takers to group or sequence items according to a set of complex rules. We recruited young adults who were enrolled in an LSAT course that offers 70 h of reasoning instruction (n = 25), and age- and IQ-matched controls intending to take the LSAT in the future (n = 24). rs-fMRI data were collected for all subjects during two scanning sessions separated by 90 d. An analysis of pairwise correlations between brain regions implicated in reasoning showed that fronto-parietal connections were strengthened, along with parietal-striatal connections. These findings provide strong evidence for neural plasticity at the level of large-scale networks supporting high-level cognition. PMID:23486950

  13. Multifractal analysis of resting state networks in functional MRI

    International Nuclear Information System (INIS)

    It has been know for at least one decade that functional MRI time series display long-memory properties, such as power-law scaling in the frequency spectrum. Concomitantly, multivariate model free analysis of spatial patterns, such as spatial Independent Component Analysis (sICA), has been successfully used to segment from spontaneous activity Resting-State Networks (RSN) that correspond to known brain function. As recent neuro-scientific studies suggest a link between spectral properties of brain activity and cognitive processes, a burning question emerges: can temporal scaling properties offer new markers of brain states encoded in these large scale networks? In this paper, we combine two recent methodologies: group-level canonical ICA for multi-subject segmentation of brain network, and wavelet leader-based multifractal formalism for the analysis of RSN scaling properties. We identify the brain networks that elicit self-similarity or multi-fractality and explore which spectral properties correspond specifically to known functionally relevant processes in spontaneous activity. (authors)

  14. Computerized two-lead resting ECG analysis for the detection of coronary artery stenosis

    OpenAIRE

    Eberhard Grube, Andreas Bootsveld, Seyrani Yuecel, Joseph T. Shen, Michael Imhoff

    2007-01-01

    Background: Resting electrocardiogram (ECG) shows limited sensitivity and specificity for the detection of coronary artery disease (CAD). Several methods exist to enhance sensitivity and specificity of resting ECG for diagnosis of CAD, but such methods are not better than a specialist's judgement. We compared a new computer-enhanced, resting ECG analysis device, 3DMP, to coronary angiography to evaluate the device's accuracy in detecting hemodynamically relevant CAD. Methods: A convenience sa...

  15. Combinations of resting RSA and RSA reactivity impact maladaptive mood repair and depression symptoms

    OpenAIRE

    Yaroslavsky, Ilya; Bylsma, Lauren M.; Rottenberg, Jonathan; Kovacs, Maria

    2013-01-01

    We examined whether the combined indices of respiratory sinus arrhythmia at rest (resting RSA) and in response to a sad film (RSA reactivity) predict effective and ineffective responses to reduce sadness (adaptive vs. maladaptive mood repair) in women with histories of juvenile-onset depression (n = 74) and no history of major mental disorders (n = 75). Structural equation models were used to estimate latent resting RSA, depression, and adaptive and maladaptive mood repair and to test the stu...

  16. Rest-to-Rest Attitude Naneuvers and Residual Vibration Reduction of a Finite Element Model of Flexible Satellite by Using Input Shaper

    OpenAIRE

    Setyamartana Parman; Hideo Koguchi

    1999-01-01

    A three-dimensional rest-to-rest attitude maneuver of flexible spacecraft equipped by on-off reaction jets is studied. Equations of motion of the spacecraft is developed by employing a hybrid system of coordinates and Lagrangian formulation. The finite element method is used to examine discrete elastic deformations of a particular model of satellite carrying flexible solar panels by modelling the panels as flat plate structures in bending. Results indicate that, under an unshaped input, the m...

  17. Rapid Deployment of a RESTful Service for Oceanographic Research Cruises

    Science.gov (United States)

    Fu, Linyun; Arko, Robert; Leadbetter, Adam

    2014-05-01

    The Ocean Data Interoperability Platform (ODIP) seeks to increase data sharing across scientific domains and international boundaries, by providing a forum to harmonize diverse regional data systems. ODIP participants from the US include the Rolling Deck to Repository (R2R) program, whose mission is to capture, catalog, and describe the underway/environmental sensor data from US oceanographic research vessels and submit the data to public long-term archives. R2R publishes information online as Linked Open Data, making it widely available using Semantic Web standards. Each vessel, sensor, cruise, dataset, person, organization, funding award, log, report, etc, has a Uniform Resource Identifier (URI). Complex queries that federate results from other data providers are supported, using the SPARQL query language. To facilitate interoperability, R2R uses controlled vocabularies developed collaboratively by the science community (eg. SeaDataNet device categories) and published online by the NERC Vocabulary Server (NVS). In response to user feedback, we are developing a standard programming interface (API) and Web portal for R2R's Linked Open Data. The API provides a set of simple REST-type URLs that are translated on-the-fly into SPARQL queries, and supports common output formats (eg. JSON). We will demonstrate an implementation based on the Epimorphics Linked Data API (ELDA) open-source Java package. Our experience shows that constructing a simple portal with limited schema elements in this way can significantly reduce development time and maintenance complexity.

  18. The influence of low-grade glioma on resting state oscillatory brain activity: a magnetoencephalography study

    OpenAIRE

    Bosma, I.; Stam, C.; Douw, L.; Bartolomei, F.; Heimans, J.; van Dijk; Postma, T.; Klein, M.; Reijneveld, J.

    2008-01-01

    Purpose: In the present MEG-study, power spectral analysis of oscillatory brain activity was used to compare resting state brain activity in both low-grade glioma (LGG) patients and healthy controls. We hypothesized that LGG patients show local as well as diffuse slowing of resting state brain activity compared to healthy controls and that particularly global slowing correlates with neurocognitive dysfunction. Patient and methods Resting state MEG recordings were obtained from 17 LGG patients...

  19. Experimental evaluation of the influence of various rests on task performance

    International Nuclear Information System (INIS)

    This report deals with the result of the experiment that 8 subjects had executed adding task and search task. They executed each task in 80 minutes under 5 conditions: (1) with no rest, and with 4 kinds of 20 minutes rests, in which they (2) opened eyes, (3) closed eyes, (4) closed eyes with listening classic music and (5) closed eyes with feet massage, in the middle of the task. The results of analysis of variance with the task performance in the latter half, there were significant differences between each condition with every subject in adding task, and with 6 subjects in search task. However, the orders of the task performance with each condition were not the same by each subject. It was suggested that transition of the arousal levels under the rest was related to the effects of the rest rather than the subjects' taste in rests. In the rest, the percentage of α wave of electroencephalogram and the coefficient of variation of R-R interval (time interval of heart beats) were increased than in executing task. The mean Kendall's rank correlation of coefficient with the order of increase rate of α/β wave and the task performance in the latter half was slightly negative in adding task, but was about 0.4 in search task. From these results, about six requirements for 'an effective rest' were able to be mentioned, for example, 'the devices that raises the arousal levels is carried out just before a rest end'. (author)

  20. Cancellous bone structure of iliac crest biopsies following 370 days of head-down bed rest

    DEFF Research Database (Denmark)

    Thomsen, Jesper Skovhus; Morukov, Boris V.; Vico, Laurence;

    2005-01-01

    x d(-1)) for the entire study period. Five subjects underwent 120 d of bed rest without countermeasures followed by 250 d of bed rest with the exercise regimen. Transiliac bone biopsies were obtained either at baseline and day 366, or at baseline, day 116, and day 366 at alternating sides of the...

  1. Changes in Activation of Abdominal Muscles at Selected Angles During Trunk Exercise by Using Ultrasonography

    Science.gov (United States)

    Kim, Hyun-Dong; Bae, Hyun-Woo; Kim, Jong-Gil; Han, Nami; Eom, Mi-Ja

    2015-01-01

    Objective To investigate the changes of activation of the abdominal muscles depending on exercise angles and whether the activation of rectus abdominis differs according to the location, during curl up and leg raise exercises, by measuring the thickness ratio of abdominal muscles using ultrasonography. Methods We examined 30 normal adults without musculoskeletal problems. Muscle thickness was measured in the upper rectus abdominis (URA), lower rectus abdominis (LRA), obliquus externus (EO), obliquus internus (IO), and transversus abdominis (TrA), at pre-determined angles (30°, 60°, 90°) and additionally at the resting angle (0°). Muscle thickness ratio was calculated by dividing the resting (0°) thickness for each angle, and was used as reflection of muscle activity. Results The muscle thickness ratio was significantly different depending on the angles in URA and LRA. For curl up-URA p=0 (30°90°), p=0.44 (30°90°), p=0.44 (30°>90°), respectively, by one-way ANOVA test-and for leg raise-URA p=0 (30°<60°), p=0 (60°<90°), p=0 (30°<90°) and LRA p=0.01 (30°<60°), p=0 (60°<90°), p=0 (30°<90°), respectively, by one-way ANOVA test-exercises, but not in the lateral abdominal muscles (EO, IO, and TrA). Also, there was no significant difference in the muscle thickness ratio of URA and LRA during both exercises. In the aspect of muscle activity, there was significant difference in the activation of RA muscle by selected angles, but not according to location during both exercises. Conclusion According to this study, exercise angle is thought to be an important contributing factor for strengthening of RA muscle; however, both the exercises are thought to have no property of strengthening RA muscle selectively based on the location. PMID:26798609

  2. Contact angles of liquid metals on quasicrystals

    International Nuclear Information System (INIS)

    Wetting with μm-sized Pb droplets on thin polycrystalline films of decagonal Al13Co4 is reported. The films were prepared under high vacuum conditions in order to have Pb droplets lying on a clean surface. The method used is sequential deposition and annealing of specific stackings of Al and Co layers of nanometric thicknesses. A 300 nm thick Pb slab was then deposited on top of the films and dewetting experiments were followed in situ in a scanning Auger microprobe. The contact angle between the Pb droplet and the surface of the film is measured to be 49 deg. ± 7 deg. Further investigation performed by cross section transmission electron microscopy allows us to better characterize the interface. Taking into account the rugosity of the film, it is concluded that there is partial wetting of the film, which corresponds to a smaller contact angle. The comparison with other results obtained either with pure metals or with a cubic AlCo compound leads to the conclusion that the wetting behaviour of Pb on the surface of a decagonal compound is close to that of a metal with a high melting point and not significantly different from that of a crystalline compound with a small unit cell

  3. Recovery of resting brain connectivity ensuing mild traumatic brain injury

    Directory of Open Access Journals (Sweden)

    Rose Dawn Bharath

    2015-09-01

    Full Text Available Brains reveal amplified plasticity as they recover from an injury. We aimed to define time dependent plasticity changes in patients recovering from mild traumatic brain injury (mTBI. 25 subjects with mild head injury were longitudinally evaluated within 36 hours, 3 and 6 months using resting state functional connectivity (RSFC. Region of interest (ROI based connectivity differences over time within the patient group and in comparison with a healthy control group were analyzed at p<0.005. We found 33 distinct ROI pairs that revealed significant changes in their connectivity strength with time. Within three months, the majority of the ROI pairs had decreased connectivity in mTBI population, which increased and became comparable to healthy controls at 6 months. Initial imaging within 36 hours of injury revealed hyper connectivity predominantly involving the salience network and default mode network, which reduced at 3 months when lingual, inferior frontal and fronto-parietal networks revealed hyper connectivity. At six months all the evaluated networks revealed hyper connectivity and became comparable to the healthy controls. Our findings in a fairly homogenous group of patients with mTBI evaluated during the 6 month window of recovery defines time varying brain connectivity changes as the brain recovers from an injury. A majority of these changes were seen in the frontal and parietal lobes between 3-6 months after injury. Hyper connectivity of several networks supported normal recovery in the first six months and it remains to be seen in future studies whether this can predict an early and efficient recovery of brain function.

  4. New discovery: Quantization of atomic and nuclear rest mass differences

    International Nuclear Information System (INIS)

    We come to the conclusion that all atomic models based on either the Newton equation and the Kepler laws, or the Maxwell equations, or the Schrodinger and Dirac equations are in reasonable agreement with experimental data. We can only suspect that these equations are grounded on the same fundamental principle(s) which is (are) not known or these equations can be transformed into each other. We proposed a new mechanism of LENR: cooperative processes in the whole system - nuclei + atoms + condensed matter - nuclear reactions in plasma - can occur at smaller threshold energies than the corresponding ones on free constituents. We were able to quantize [1] phenomenologically the first time the differences between atomic and nuclear rest masses by the formula: ΔΔ M = n1/n2 x 0.0076294 (in MeV/c2 ), ni=1,2,3,... Note that this quantization rule is justified for atoms and nuclei with different A, N and Z and the nuclei and atoms represent a coherent synchronized open systems - a complex of coupled oscillators (resonators). The cooperative resonance synchronization mechanisms are responsible for explanation of how the electron volt world can influence on the nuclear mega electron volt world. It means that we created new possibilities for inducing and controlling nuclear reactions by atomic processes grounded on the fundamental low of physics - conservation law of energy. The results of these research fields can provide new ecologically pure mobile sources of energy independent from oil, gas and coal, new substances, and technologies. For example, this discovery gives us a simple and cheep method for utilization of nuclear waste. References [1] F.A. Gareev, I.E. Zhidkova, E-print arXiv Nucl-th/0610002 2006

  5. Frequency dependent topological patterns of resting-state brain networks.

    Directory of Open Access Journals (Sweden)

    Long Qian

    Full Text Available The topological organization underlying brain networks has been extensively investigated using resting-state fMRI, focusing on the low frequency band from 0.01 to 0.1 Hz. However, the frequency specificities regarding the corresponding brain networks remain largely unclear. In the current study, a data-driven method named complementary ensemble empirical mode decomposition (CEEMD was introduced to separate the time series of each voxel into several intrinsic oscillation rhythms with distinct frequency bands. Our data indicated that the whole brain BOLD signals could be automatically divided into five specific frequency bands. After applying the CEEMD method, the topological patterns of these five temporally correlated networks were analyzed. The results showed that global topological properties, including the network weighted degree, network efficiency, mean characteristic path length and clustering coefficient, were observed to be most prominent in the ultra-low frequency bands from 0 to 0.015 Hz. Moreover, the saliency of small-world architecture demonstrated frequency-density dependency. Compared to the empirical mode decomposition method (EMD, CEEMD could effectively eliminate the mode-mixing effects. Additionally, the robustness of CEEMD was validated by the similar results derived from a split-half analysis and a conventional frequency division method using the rectangular window band-pass filter. Our findings suggest that CEEMD is a more effective method for extracting the intrinsic oscillation rhythms embedded in the BOLD signals than EMD. The application of CEEMD in fMRI data analysis will provide in-depth insight in investigations of frequency specific topological patterns of the dynamic brain networks.

  6. Recommendation System of Program Based on REST Style

    Directory of Open Access Journals (Sweden)

    Song Jin Bao

    2016-01-01

    Full Text Available With the popularity of digital TV, TV programs have been on the increase no matter in both the number and species, which brought many choice to the users. Although the digital TV has increased largely in the selectivity, it has become a fussy process that users search for programs which they are interested in. So there is need to have an efficient program recommendation system to solve the problem that is “information overload” for users. It can not only help users to get the program which they require, but also bring convenience to people’s life. The program recommendation system named MyView is planned and designed, aimed to providing an efficient information platform. The system also involves intelligent recommendation. The information guide will trigger the recommendation engine after users registering information, the engine will accord to the data in the guide information to make the personalized program recommendation. The system was deployed in the Tomcat and Apache integration servers on my localhost, so it also belongs to the Web application based on J2EE platform. AJAX is used that can achieve a good user experience to develop web presentation layer on MyView PC browser with flexible interface performance. The background of business services uses the hierarchical form. MyView System uses the CXF framework and Hibernate to equip controller and data persistence layer in the Spring container. The overall framework of the system uses the REST style, in order to extend the performance and function later. Background service layer with uniform interface, marked by the URI resource. At the same time, HTTP requestion is submitted by the AJAX to obtain services provided by resources. Finally, we can analyze and summary the features of MyView System.

  7. A comparison of the rest complex binding patterns in embryonic stem cells and epiblast stem cells.

    Directory of Open Access Journals (Sweden)

    Masahide Seki

    Full Text Available We detected and characterized the binding sites of the representative Rest complex components Rest, Sin3A, and Lsd1. We compared their binding patterns in mouse embryonic stem (ES cells and epiblast stem (EpiS cells. We found few Rest sites unique to the EpiS cells. The ES-unique site features were distinct from those of the common sites, namely, the signal intensities were weaker, and the characteristic gene function categories differed. Our analyses showed that the Rest binding sites do not always overlap with the Sin3A and Lsd1 binding sites. The Sin3A binding pattern differed remarkably between the ES and EpiS cells and was accompanied by significant changes in acetylated-histone patterns in the surrounding regions. A series of transcriptome analyses in the same cell types unexpectedly showed that the putative target gene transcript levels were not dramatically different despite dynamic changes in the Rest complex binding patterns and chromatin statuses, which suggests that Rest is not the sole determinant of repression at its targets. Nevertheless, we identified putative Rest targets with explicitly enhanced transcription upon Rest knock-down in 143 and 60 common and ES-unique Rest target genes, respectively. Among such sites, several genes are involved in ES cell proliferation. In addition, we also found that long, intergenic non-coding RNAs were apparent Rest targets and shared similar features with the protein-coding target genes. Interestingly, such non-coding target genes showed less conservation through evolution than protein-coding targets. As a result of differences in the components and targets of the Rest complex, its functional roles may differ in ES and EpiS cells.

  8. Lateral Pressure at Rest of Non-cohesive Sand

    Czech Academy of Sciences Publication Activity Database

    Koudelka, Petr

    Vol. #8. Bratislava : STU Bratislava, 2010, s. 1-11. ISBN 978-80-227-3279-6. [Danube-European conference on Geotechnical engineering /15./. Bratislava (SK), 02.06.2010-04.06.2010] R&D Projects: GA ČR(CZ) GA103/08/1617 Institutional research plan: CEZ:AV0Z20710524 Keywords : lateral/earth pressure * active/passive pressure at rest * physical experiments Subject RIV: BM - Solid Matter Physics ; Magnetism

  9. Dopamine modulates the rest period length without perturbation of its power law distribution in Drosophila melanogaster.

    Directory of Open Access Journals (Sweden)

    Taro Ueno

    Full Text Available We analyzed the effects of dopamine signaling on the temporal organization of rest and activity in Drosophila melanogaster. Locomotor behaviors were recorded using a video-monitoring system, and the amounts of movements were quantified by using an image processing program. We, first, confirmed that rest bout durations followed long-tailed (i.e., power-law distributions, whereas activity bout durations did not with a strict method described by Clauset et al. We also studied the effects of circadian rhythm and ambient temperature on rest bouts and activity bouts. The fraction of activity significantly increased during subjective day and at high temperature, but the power-law exponent of the rest bout distribution was not affected. The reduction in rest was realized by reduction in long rest bouts. The distribution of activity bouts did not change drastically under the above mentioned conditions. We then assessed the effects of dopamine. The distribution of rest bouts became less long-tailed and the time spent in activity significantly increased after the augmentation of dopamine signaling. Administration of a dopamine biosynthesis inhibitor yielded the opposite effects. However, the distribution of activity bouts did not contribute to the changes. These results suggest that the modulation of locomotor behavior by dopamine is predominantly controlled by changing the duration of rest bouts, rather than the duration of activity bouts.

  10. Neuroendocrine and Behavioral Effects of Vasopressin in Resting and Mild Stress Conditions

    NARCIS (Netherlands)

    Buwalda, B.; Nyakas, C.; Koolhaas, J.M.; Bohus, B.

    1993-01-01

    Neuroendocrine and behavioral effects of subcutaneously administered AVP (6 mug/kg b.wt.) were determined in resting conditions and after the mild stress of transportation to and placement in a novel environment. In resting conditions, systemic administration of AVP caused a rapid increase in blood

  11. Predictive modeling of spinner dolphin (Stenella longirostris resting habitat in the main Hawaiian Islands.

    Directory of Open Access Journals (Sweden)

    Lesley H Thorne

    Full Text Available Predictive habitat models can provide critical information that is necessary in many conservation applications. Using Maximum Entropy modeling, we characterized habitat relationships and generated spatial predictions of spinner dolphin (Stenella longirostris resting habitat in the main Hawaiian Islands. Spinner dolphins in Hawai'i exhibit predictable daily movements, using inshore bays as resting habitat during daylight hours and foraging in offshore waters at night. There are growing concerns regarding the effects of human activities on spinner dolphins resting in coastal areas. However, the environmental factors that define suitable resting habitat remain unclear and must be assessed and quantified in order to properly address interactions between humans and spinner dolphins. We used a series of dolphin sightings from recent surveys in the main Hawaiian Islands and a suite of environmental variables hypothesized as being important to resting habitat to model spinner dolphin resting habitat. The model performed well in predicting resting habitat and indicated that proximity to deep water foraging areas, depth, the proportion of bays with shallow depths, and rugosity were important predictors of spinner dolphin habitat. Predicted locations of suitable spinner dolphin resting habitat provided in this study indicate areas where future survey efforts should be focused and highlight potential areas of conflict with human activities. This study provides an example of a presence-only habitat model used to inform the management of a species for which patterns of habitat availability are poorly understood.

  12. Distribution of angles in hyperbolic lattices

    DEFF Research Database (Denmark)

    Risager, Morten Skarsholm; Truelsen, Jimi Lee

    2010-01-01

    We prove an effective equidistribution result about angles in a hyperbolic lattice. We use this to generalize a result from the study by Boca.......We prove an effective equidistribution result about angles in a hyperbolic lattice. We use this to generalize a result from the study by Boca....

  13. Distribution of Angles in Hyperbolic Lattices

    DEFF Research Database (Denmark)

    S. Risager, Morten; L. Truelsen, Jimi

    2008-01-01

    We prove an effective equidistribution result about angles in a hyperbolic lattice. We use this to generalize a result due to F. P. Boca.......We prove an effective equidistribution result about angles in a hyperbolic lattice. We use this to generalize a result due to F. P. Boca....

  14. Angle-independent structural colors of silicon

    DEFF Research Database (Denmark)

    Højlund-Nielsen, Emil; Weirich, Johannes; Nørregaard, Jesper;

    2014-01-01

    Structural colors are optical phenomena of physical origin, where microscale and nanoscale structures determine the reflected spectrum of light. Artificial structural colors have been realized within recent years. However, multilayer structures require substantial fabrication. Instead we considered...... one-layer surface textures of silicon.We explored four patterns of square structures in a square lattice with periods of 500, 400, 300, and 200 nm. The reflectivity and daylight-colors were measured and compared with simulations based on rigorously coupledwave analysis with excellent agreement. Based...... on the 200-nm periodic pattern, it was found that angle-independent specular colors up to 60 deg of incidence may be provided. The underlying mechanisms include (1) the suppression of diffraction and (2) a strong coupling of light to localized surface states. The strong coupling yields absorption...

  15. In Vivo measurement of human body composition. [during continuous bed rest

    Science.gov (United States)

    Pace, N.; Grunbaum, B. W.; Kodama, A. M.; Price, D. C.

    1975-01-01

    Physiological changes in human beings were studied during a 21 day bed rest regime. Results of blood analyses indicated clearly that major metabolic adjustments occurred during prolonged bed rest. However, urinary metabolic analyses showed variances attributed to specimen collection inaccuracies and the small number of test subjects.

  16. Impact of wheat flour-associated endoxylanases on arabinoxylan in dough after mixing and resting.

    Science.gov (United States)

    Dornez, Emmie; Gebruers, Kurt; Cuyvers, Sven; Delcour, Jan A; Courtin, Christophe M

    2007-08-22

    The impact of varying levels of endoxylanase activity in wheat flour on arabinoxylan (AX) in mixed and rested dough was studied using eight industrially milled wheat flour fractions with varying endoxylanase activity levels. Analysis of the levels of reducing end xylose (RX) and solubilized AX (S-AX) formed during mixing and resting and their correlation with the endoxylanase activity in the flour milling fractions showed that solubilization of AX during the mixing phase is mainly due to mechanical forces, while solubilization of AX during resting is caused by endoxylanase activity. Moreover, solubilization of AX during the dough resting phase is more outspoken than that during the mixing phase. Besides endoxylanase activity, there were significant xylosidase and arabinofuranosidase activities during the dough resting phase. The results indicate that wheat flour-associated endoxylanases can alter part of the AX in dough, thereby changing their functionality in bread making and potentially affecting dough and end product properties. PMID:17661495

  17. REST-mediated recruitment of polycomb repressor complexes in mammalian cells

    DEFF Research Database (Denmark)

    Dietrich, Nikolaj; Lerdrup, Mads; Landt, Eskild;

    2012-01-01

    Polycomb Repressive Complex (PRC) 1 and PRC2 regulate genes involved in differentiation and development. However, the mechanism for how PRC1 and PRC2 are recruited to genes in mammalian cells is unclear. Here we present evidence for an interaction between the transcription factor REST, PRC1, and...... increased gene expression. Genome-wide analysis of Polycomb binding in Rest¿/¿ and Eed¿/¿ mouse embryonic stem (mES) cells showed that Rest was required for PRC1 recruitment to a subset of Polycomb regulated neuronal genes. Furthermore, we found that PRC1 can be recruited to Rest binding sites independently...... of CpG islands and the H3K27Me3 mark. Surprisingly, PRC2 was frequently increased around Rest binding sites located in CpG-rich regions in the Rest¿/¿ mES cells, indicating a more complex interplay where Rest also can limit PRC2 recruitment. Therefore, we propose that Rest has context...

  18. Being at Rest

    OpenAIRE

    Snyder, D. M.

    2001-01-01

    As a subject, an observer is fundamentally at rest in a reference frame, and this being at rest allows for measuring the motion of physical objects. Exploring the experience of centrifugal force brings to the fore the natural inclination to see oneself at rest in a reference frame. The discrepancy between the experience of centrifugal force and its lack of fundamental significance in Newton's laws of motion points toward the importance of the observer as a subject in his or her own reference ...

  19. Wakeful rest promotes the integration of spatial memories into accurate cognitive maps.

    Science.gov (United States)

    Craig, Michael; Dewar, Michaela; Harris, Mathew A; Della Sala, Sergio; Wolbers, Thomas

    2016-02-01

    Flexible spatial navigation, e.g. the ability to take novel shortcuts, is contingent upon accurate mental representations of environments-cognitive maps. These cognitive maps critically depend on hippocampal place cells. In rodents, place cells replay recently travelled routes, especially during periods of behavioural inactivity (sleep/wakeful rest). This neural replay is hypothesised to promote not only the consolidation of specific experiences, but also their wider integration, e.g. into accurate cognitive maps. In humans, rest promotes the consolidation of specific experiences, but the effect of rest on the wider integration of memories remained unknown. In the present study, we examined the hypothesis that cognitive map formation is supported by rest-related integration of new spatial memories. We predicted that if wakeful rest supports cognitive map formation, then rest should enhance knowledge of overarching spatial relations that were never experienced directly during recent navigation. Forty young participants learned a route through a virtual environment before either resting wakefully or engaging in an unrelated perceptual task for 10 min. Participants in the wakeful rest condition performed more accurately in a delayed cognitive map test, requiring the pointing to landmarks from a range of locations. Importantly, the benefit of rest could not be explained by active rehearsal, but can be attributed to the promotion of consolidation-related activity. These findings (i) resonate with the demonstration of hippocampal replay in rodents, and (ii) provide the first evidence that wakeful rest can improve the integration of new spatial memories in humans, a function that has, hitherto, been associated with sleep. PMID:26235141

  20. Transcriptional activation of REST by Sp1 in Huntington's disease models.

    Directory of Open Access Journals (Sweden)

    Myriam Ravache

    Full Text Available In Huntington's disease (HD, mutant huntingtin (mHtt disrupts the normal transcriptional program of disease neurons by altering the function of several gene expression regulators such as Sp1. REST (Repressor Element-1 Silencing Transcription Factor, a key regulator of neuronal differentiation, is also aberrantly activated in HD by a mechanism that remains unclear. Here, we show that the level of REST mRNA is increased in HD mice and in NG108 cells differentiated into neuronal-like cells and expressing a toxic mHtt fragment. Using luciferase reporter gene assay, we delimited the REST promoter regions essential for mHtt-mediated REST upregulation and found that they contain Sp factor binding sites. We provide evidence that Sp1 and Sp3 bind REST promoter and interplay to fine-tune REST transcription. In undifferentiated NG108 cells, Sp1 and Sp3 have antagonistic effect, Sp1 acting as an activator and Sp3 as a repressor. Upon neuronal differentiation, we show that the amount and ratio of Sp1/Sp3 proteins decline, as does REST expression, and that the transcriptional role of Sp3 shifts toward a weak activator. Therefore, our results provide new molecular information to the transcriptional regulation of REST during neuronal differentiation. Importantly, specific knockdown of Sp1 abolishes REST upregulation in NG108 neuronal-like cells expressing mHtt. Our data together with earlier reports suggest that mHtt triggers a pathogenic cascade involving Sp1 activation, which leads to REST upregulation and repression of neuronal genes.

  1. Temperature Influence on Divergence Angles of Quartz Crystal Wollaston Prism

    International Nuclear Information System (INIS)

    We propose a structural angle and main refractive indices as two key factors to understand the temperature influence on the divergence angles of the Wollaston prism. The temperature influence on the divergence angles of quartz crystal Wollaston prism is studied theoretically The results show that divergence angles decrease with increasing temperature, while the divergence angle of e-light decrease more quickly than that of o-light. The testing system is established to verify the above results, and the experimental results are in agreement well with the theoretical analysis. (fundamental areas of phenomenology (including applications))

  2. The Effects of Long Duration Bed Rest on Brain Functional Connectivity and Sensorimotor Functioning

    Science.gov (United States)

    Cassady, K.; Koppelmans, V.; De Dios, Y.; Stepanyan, V.; Szecsy, D.; Gadd, N.; Wood, S.; Reuter-Lorenz, P.; Castenada, R. Riascos; Kofman, I.; Bloomberg, J.; Mulavara, A; Seidler, R.

    2016-01-01

    Long duration spaceflight has been associated with detrimental alterations in human sensorimotor functioning. Prolonged exposure to a head-down tilt (HDT) position during long duration bed rest can resemble several effects of the microgravity environment such as reduced sensory inputs, body unloading and increased cephalic fluid distribution. The question of whether microgravity affects other central nervous system functions such as brain functional connectivity and its relationship with behavior is largely unknown, but of importance to the health and performance of astronauts both during and post-flight. In the present study, we investigate the effects of prolonged exposure to HDT bed rest on resting state brain functional connectivity and its association with behavioral changes in 17 male participants. To validate that our findings were not due to confounding factors such as time or task practice, we also acquired resting state functional magnetic resonance imaging (rs-fMRI) and behavioral measurements from 14 normative control participants at four time points. Bed rest participants remained in bed with their heads tilted down six degrees below their feet for 70 consecutive days. Rs-fMRI and behavioral data were obtained at seven time points averaging around: 12 and 8 days prior to bed rest; 7, 50, and 70 days during bed rest; and 8 and 12 days after bed rest. 70 days of HDT bed rest resulted in significant increases in functional connectivity during bed rest followed by a reversal of changes in the post bed rest recovery period between motor cortical and somatosensory areas of the brain. In contrast, decreases in connectivity were observed between temporoparietal regions. Furthermore, post-hoc correlation analyses revealed a significant relationship between motor-somatosensory network connectivity and standing balance performance changes; participants that exhibited the greatest increases in connectivity strength showed the least deterioration in postural

  3. Serial thallium-201 imaging at rest in patients with unstable and stable angina pectoris: relationship of myocardial perfusion at rest to presenting clinical syndrome

    International Nuclear Information System (INIS)

    In order to determine whether there are differences in myocardial perfusion at rest among patients with various unstable and stable angina syndromes, serial thallium-201 imaging was performed at rest in 19 patients presenting with rapidly worsening exertional angina (unstable angina, group A), 12 patients with rest angina alone without exertional symptoms (unstable angina, group B), and 34 patients with chronic stable angina. No patient had an episode of angina within 4 hours of study. Nineteen of 19 (100%) patients in group A demonstrated transient defects compared to only 3 of 12 (25%) patients in group B (p less than 0.0001) and 4 of 34 (12%) stable angina patients (p less than 0.0001). The majority of zones demonstrating transient defects in group A were associated with hypokinesis of the corresponding left ventriculogram segment without associated ECG evidence of previous infarction. There were no significant differences in the frequency of persistent thallium defects, severity of angiographic coronary artery disease, or frequency of regional wall motion abnormalities of myocardial segments supplied by stenotic coronary arteries among the three groups of patients. Transient defects have been shown to reflect reduction in regional coronary blood flow to viable myocardium. Therefore, we conclude that regional resting hypoperfusion of viable myocardium is far more common in patients with exertional unstable angina symptoms than in patients with rest angina alone or chronic stable angina

  4. Impacts of tropical cyclone inflow angle on ocean surface waves

    Institute of Scientific and Technical Information of China (English)

    ZHAO Wei; HONG Xin

    2011-01-01

    The inflow angle of tropical cyclones (TC) is generally neglected in numerical studies of ocean surface waves induced by TC. In this study, the impacts of TC inflow angle on ocean surface waves were investigated using a high-resolution wave model. Six numerical experiments were conducted to examine, in detail, the effects of inflow angle on mean wave parameters and the spectrum of wave directions. A comparison of the waves simulated in these experiments shows that inflow angle significantly modifies TC-induced ocean surface waves. As the inflow angle increases, the asymmetric axis of the significant wave height (SWH) field shifts 30° clockwise, and the maximum SWH moves from the front-right to the rear-right quadrant. Inflow angle also affects other mean wave parameters, especially in the rear-left quadrant, such as the mean wave direction, the mean wavelength, and the peak direction. Inflow angle is a key factor in wave models for the reproduction of double-peak or multi-peak patterns in the spectrum of wave directions. Sensitivity experiments also show that the simulation with a 40° inflow angle is the closest to that of the NOAA statistical SLOSH inflow angle. This suggests that 40° can be used as the inflow angle in future TC-induced ocean surface wave simulations when SLOSH or observed inflow angles are not available.

  5. The self and its resting state in consciousness: an investigation of the vegetative state.

    Science.gov (United States)

    Huang, Zirui; Dai, Rui; Wu, Xuehai; Yang, Zhi; Liu, Dongqiang; Hu, Jin; Gao, Liang; Tang, Weijun; Mao, Ying; Jin, Yi; Wu, Xing; Liu, Bin; Zhang, Yao; Lu, Lu; Laureys, Steven; Weng, Xuchu; Northoff, Georg

    2014-05-01

    Recent studies have demonstrated resting-state abnormalities in midline regions in vegetative state/unresponsive wakefulness syndrome and minimally conscious state patients. However, the functional implications of these resting-state abnormalities remain unclear. Recent findings in healthy subjects have revealed a close overlap between the neural substrate of self-referential processing and the resting-state activity in cortical midline regions. As such, we investigated task-related neural activity during active self-referential processing and various measures of resting-state activity in 11 patients with disorders of consciousness (DOC) and 12 healthy control subjects. Overall, the results revealed that DOC patients exhibited task-specific signal changes in anterior and posterior midline regions, including the perigenual anterior cingulate cortex (PACC) and posterior cingulate cortex (PCC). However, the degree of signal change was significantly lower in DOC patients compared with that in healthy subjects. Moreover, reduced signal differentiation in the PACC predicted the degree of consciousness in DOC patients. Importantly, the same midline regions (PACC and PCC) in DOC patients also exhibited severe abnormalities in the measures of resting-state activity, that is functional connectivity and the amplitude of low-frequency fluctuations. Taken together, our results provide the first evidence of neural abnormalities in both the self-referential processing and the resting state in midline regions in DOC patients. This novel finding has important implications for clinical utility and general understanding of the relationship between the self, the resting state, and consciousness. PMID:23818102

  6. Resting lateralized activity predicts the cortical response and appraisal of emotions: an fNIRS study.

    Science.gov (United States)

    Balconi, Michela; Grippa, Elisabetta; Vanutelli, Maria Elide

    2015-12-01

    This study explored the effect of lateralized left-right resting brain activity on prefrontal cortical responsiveness to emotional cues and on the explicit appraisal (stimulus evaluation) of emotions based on their valence. Indeed subjective responses to different emotional stimuli should be predicted by brain resting activity and should be lateralized and valence-related (positive vs negative valence). A hemodynamic measure was considered (functional near-infrared spectroscopy). Indeed hemodynamic resting activity and brain response to emotional cues were registered when subjects (N = 19) viewed emotional positive vs negative stimuli (IAPS). Lateralized index response during resting state, LI (lateralized index) during emotional processing and self-assessment manikin rating were considered. Regression analysis showed the significant predictive effect of resting activity (more left or right lateralized) on both brain response and appraisal of emotional cues based on stimuli valence. Moreover, significant effects were found as a function of valence (more right response to negative stimuli; more left response to positive stimuli) during emotion processing. Therefore, resting state may be considered a predictive marker of the successive cortical responsiveness to emotions. The significance of resting condition for emotional behavior was discussed. PMID:25862673

  7. Superwide-angle acoustic propagations above the critical angles of the Snell law in liquid—solid superlattice

    International Nuclear Information System (INIS)

    In this paper, superwide-angle acoustic propagations above the critical angles of the Snell law in liquid—solid superlattice are investigated. Incident waves above the critical angles of the Snell law usually inevitably induce total reflection. However, incident waves with big oblique angles through the liquid—solid superlattice will produce a superwide angle transmission in a certain frequency range so that total reflection does not occur. Together with the simulation by finite element analysis, theoretical analysis by using transfer matrix method suggests the Bragg scattering of the Lamb waves as the physical mechanism of acoustic wave super-propagation far beyond the critical angle. Incident angle, filling fraction, and material thickness have significant influences on propagation. Superwide-angle propagation phenomenon may have potential applications in nondestructive evaluation of layered structures and controlling of energy flux. (electromagnetism, optics, acoustics, heat transfer, classical mechanics, and fluid dynamics)

  8. The effects of rehabilitation on the muscles of the trunk following prolonged bed rest

    OpenAIRE

    Hides, Julie A.; Lambrecht, Gunda; Richardson, Carolyn A.; Stanton, Warren R.; Armbrecht, Gabriele; Pruett, Casey; Damann, Volker; Felsenberg, Dieter; Belavý, Daniel L.

    2010-01-01

    Microgravity and inactivity due to prolonged bed rest have been shown to result in atrophy of spinal extensor muscles such as the multifidus, and either no atrophy or hypertrophy of flexor muscles such as the abdominal group and psoas muscle. These effects are long-lasting after bed rest and the potential effects of rehabilitation are unknown. This two-group intervention study aimed to investigate the effects of two rehabilitation programs on the recovery of lumbo-pelvic musculature following...

  9. Classification of Single Normal and Alzheimer's Disease Individuals from Cortical Sources of Resting State EEG Rhythms

    OpenAIRE

    Babiloni, Claudio; Triggiani, Antonio I.; Lizio, Roberta; Cordone, Susanna; Tattoli, Giacomo; Bevilacqua, Vitoantonio; Soricelli, Andrea; Ferri, Raffaele; Nobili, Flavio; Gesualdo, Loreto; Millán-Calenti, José C.; Buján, Ana; Tortelli, Rosanna; Cardinali, Valentina; Barulli, Maria Rosaria

    2016-01-01

    Previous studies have shown abnormal power and functional connectivity of resting state electroencephalographic (EEG) rhythms in groups of Alzheimer's disease (AD) compared to healthy elderly (Nold) subjects. Here we tested the best classification rate of 120 AD patients and 100 matched Nold subjects using EEG markers based on cortical sources of power and functional connectivity of these rhythms. EEG data were recorded during resting state eyes-closed condition. Exact low-resolution brain el...

  10. Stability of whole brain and regional network topology within and between resting and cognitive states.

    Directory of Open Access Journals (Sweden)

    Justyna K Rzucidlo

    Full Text Available BACKGROUND: Graph-theory based analyses of resting state functional Magnetic Resonance Imaging (fMRI data have been used to map the network organization of the brain. While numerous analyses of resting state brain organization exist, many questions remain unexplored. The present study examines the stability of findings based on this approach over repeated resting state and working memory state sessions within the same individuals. This allows assessment of stability of network topology within the same state for both rest and working memory, and between rest and working memory as well. METHODOLOGY/PRINCIPAL FINDINGS: fMRI scans were performed on five participants while at rest and while performing the 2-back working memory task five times each, with task state alternating while they were in the scanner. Voxel-based whole brain network analyses were performed on the resulting data along with analyses of functional connectivity in regions associated with resting state and working memory. Network topology was fairly stable across repeated sessions of the same task, but varied significantly between rest and working memory. In the whole brain analysis, local efficiency, Eloc, differed significantly between rest and working memory. Analyses of network statistics for the precuneus and dorsolateral prefrontal cortex revealed significant differences in degree as a function of task state for both regions and in local efficiency for the precuneus. Conversely, no significant differences were observed across repeated sessions of the same state. CONCLUSIONS/SIGNIFICANCE: These findings suggest that network topology is fairly stable within individuals across time for the same state, but also fluid between states. Whole brain voxel-based network analyses may prove to be a valuable tool for exploring how functional connectivity changes in response to task demands.

  11. Nuclear retention of multiply spliced HIV-1 RNA in resting CD4+ T cells.

    Directory of Open Access Journals (Sweden)

    Kara G Lassen

    2006-07-01

    Full Text Available HIV-1 latency in resting CD4+ T cells represents a major barrier to virus eradication in patients on highly active antiretroviral therapy (HAART. We describe here a novel post-transcriptional block in HIV-1 gene expression in resting CD4+ T cells from patients on HAART. This block involves the aberrant localization of multiply spliced (MS HIV-1 RNAs encoding the critical positive regulators Tat and Rev. Although these RNAs had no previously described export defect, we show that they exhibit strict nuclear localization in resting CD4+ T cells from patients on HAART. Overexpression of the transcriptional activator Tat from non-HIV vectors allowed virus production in these cells. Thus, the nuclear retention of MS HIV-1 RNA interrupts a positive feedback loop and contributes to the non-productive nature of infection of resting CD4+ T cells. To define the mechanism of nuclear retention, proteomic analysis was used to identify proteins that bind MS HIV-1 RNA. Polypyrimidine tract binding protein (PTB was identified as an HIV-1 RNA-binding protein differentially expressed in resting and activated CD4+ T cells. Overexpression of PTB in resting CD4+ T cells from patients on HAART allowed cytoplasmic accumulation of HIV-1 RNAs. PTB overexpression also induced virus production by resting CD4+ T cells. Virus culture experiments showed that overexpression of PTB in resting CD4+ T cells from patients on HAART allowed release of replication-competent virus, while preserving a resting cellular phenotype. Whether through effects on RNA export or another mechanism, the ability of PTB to reverse latency without inducing cellular activation is a result with therapeutic implications.

  12. REST controls self-renewal and tumorigenic competence of human glioblastoma cells.

    Directory of Open Access Journals (Sweden)

    Luciano Conti

    Full Text Available The Repressor Element 1 Silencing Transcription factor (REST/NRSF is a master repressor of neuronal programs in non-neuronal lineages shown to function as a central regulator of developmental programs and stem cell physiology. Aberrant REST function has been associated with a number of pathological conditions. In cancer biology, REST has been shown to play a tumor suppressor activity in epithelial cancers but an oncogenic role in brain childhood malignancies such as neuroblastoma and medulloblastoma. Here we examined REST expression in human glioblastoma multiforme (GBM specimens and its role in GBM cells carrying self-renewal and tumorigenic competence. We found REST to be expressed in GBM specimens, its presence being particularly enriched in tumor cells in the perivascular compartment. Significantly, REST is highly expressed in self-renewing tumorigenic-competent GBM cells and its knock down strongly reduces their self-renewal in vitro and tumor-initiating capacity in vivo and affects levels of miR-124 and its downstream targets. These results indicate that REST contributes to GBM maintenance by affecting its self-renewing and tumorigenic cellular component and that, hence, a better understanding of these circuitries in these cells might lead to new exploitable therapeutic targets.

  13. Restoration of the root apical meristem by the transplantation of resting center

    International Nuclear Information System (INIS)

    Three-day maize seedlings, grown in the dark at 25 deg C, were irradiated by 60Co gamma-radiation in the doses 15, 20, 25 and 30 Gy. The irradiated seedlings were divided into three groups. In group 1 seedlings the root meristem was left intact. In group 2 seedlings immediately after irradiation the cap and resting centre were removed, and in group 3 seedlings in place of the removed resting centre, the resting centre, separated from the root meristem of non-irradiated seedlings, was transplanted. It was established, that just like stem cells of animals the cells of non-irradiated resting centre are able to restore the pool of normally functioning cells in tissue after its injury

  14. Plankton Resting Stages in the Marine Sediments of the Bay of Vlorë (Albania)

    OpenAIRE

    Fernando Rubino; Salvatore Moscatello; Manuela Belmonte; Gianmarco Ingrosso; Genuario Belmonte

    2013-01-01

    In the frame of the INTERREG III CISM project, sediment cores were collected at 2 stations in the Gulf of Vlorë to study the plankton resting stage assemblages. A total of 87 morphotypes were identified and produced by Dinophyta, Ciliophora, Rotifera, and Crustacea. In 22 cases, the cyst belonged to a species absent from the plankton of the same period. The most abundant resting stages were those produced by Scrippsiella species (Dinophyta). Some calcareous cysts were identified as fossil spe...

  15. Experimental evaluation of the influence of various rests on task performance

    Energy Technology Data Exchange (ETDEWEB)

    Nagasaka, Akihiko; Hirose, Ayako [Central Research Inst. of Electric Power Industry, Tokyo (Japan)

    2000-01-01

    This report deals with the result of the experiment that 8 subjects had executed adding task and search task. They executed each task in 80 minutes under 5 conditions: (1) with no rest, and with 4 kinds of 20 minutes rests, in which they (2) opened eyes, (3) closed eyes, (4) closed eyes with listening classic music and (5) closed eyes with feet massage, in the middle of the task. The results of analysis of variance with the task performance in the latter half, there were significant differences between each condition with every subject in adding task, and with 6 subjects in search task. However, the orders of the task performance with each condition were not the same by each subject. It was suggested that transition of the arousal levels under the rest was related to the effects of the rest rather than the subjects' taste in rests. In the rest, the percentage of {alpha} wave of electroencephalogram and the coefficient of variation of R-R interval (time interval of heart beats) were increased than in executing task. The mean Kendall's rank correlation of coefficient with the order of increase rate of {alpha}/{beta} wave and the task performance in the latter half was slightly negative in adding task, but was about 0.4 in search task. From these results, about six requirements for 'an effective rest' were able to be mentioned, for example, 'the devices that raises the arousal levels is carried out just before a rest end'. (author)

  16. Implicit theories about willpower predict the activation of a rest goal following self-control exertion.

    Science.gov (United States)

    Job, Veronika; Bernecker, Katharina; Miketta, Stefanie; Friese, Malte

    2015-10-01

    Past research indicates that peoples' implicit theories about the nature of willpower moderate the ego-depletion effect. Only people who believe or were led to believe that willpower is a limited resource (limited-resource theory) showed lower self-control performance after an initial demanding task. As of yet, the underlying processes explaining this moderating effect by theories about willpower remain unknown. Here, we propose that the exertion of self-control activates the goal to preserve and replenish mental resources (rest goal) in people with a limited-resource theory. Five studies tested this hypothesis. In Study 1, individual differences in implicit theories about willpower predicted increased accessibility of a rest goal after self-control exertion. Furthermore, measured (Study 2) and manipulated (Study 3) willpower theories predicted an increased preference for rest-conducive objects. Finally, Studies 4 and 5 provide evidence that theories about willpower predict actual resting behavior: In Study 4, participants who held a limited-resource theory took a longer break following self-control exertion than participants with a nonlimited-resource theory. Longer resting time predicted decreased rest goal accessibility afterward. In Study 5, participants with an induced limited-resource theory sat longer on chairs in an ostensible product-testing task when they had engaged in a task requiring self-control beforehand. This research provides consistent support for a motivational shift toward rest after self-control exertion in people holding a limited-resource theory about willpower. PMID:26075793

  17. Winter Is Coming: Seasonal Variation in Resting Metabolic Rate of the European Badger (Meles meles)

    OpenAIRE

    McClune, David W.; Kostka, Berit; Delahay, Richard J.; Montgomery, W. Ian; Marks, Nikki J.; Scantlebury, David M

    2015-01-01

    Resting metabolic rate (RMR) is a measure of the minimum energy requirements of an animal at rest, and can give an indication of the costs of somatic maintenance. We measured RMR of free-ranging European badgers (Meles meles) to determine whether differences were related to sex, age and season. Badgers were captured in live-traps and placed individually within a metabolic chamber maintained at 20 ± 1°C. Resting metabolic rate was determined using an open-circuit respirometry system. Season wa...

  18. A magnetoencephalography analysis of resting state power spectrum of inpatients with major depressive disorder

    Institute of Scientific and Technical Information of China (English)

    汤浩

    2013-01-01

    Objective To explore the discrepancies of magne-toencephalography(MEG) spectral power between female patients with major depressive disorder and nondepressed subjects in resting state. Methods Whole head MEG recordings were obtained in 12 female patients with major

  19. Reliability analysis of the resting state can sensitively and specifically identify the presence of Parkinson disease.

    Science.gov (United States)

    Skidmore, F M; Yang, M; Baxter, L; von Deneen, K M; Collingwood, J; He, G; White, K; Korenkevych, D; Savenkov, A; Heilman, K M; Gold, M; Liu, Y

    2013-07-15

    Parkinson disease (PD) is characterized by a number of motor and behavioral abnormalities that could be considered deficits of a "no task" or "resting" state, including resting motor findings and defects in emerging from a resting state (e.g., resting tremor, elevated resting tone, abulia, akinesia, apathy). PET imaging, and recently, the MRI technique of continuous arterial spin labeling (CASL) have shown evidence of changes in metabolic patterns in individuals with PD. The purpose of this study was to learn if the presence of PD could be "predicted" based on resting fluctuations of the BOLD signal. Participants were 15 healthy controls, 14 subjects with PD, and 1 subject who presented as a control but later developed PD. The amplitude of the low frequency fluctuation (ALFF) was used as an index of brain activity level in the resting state. Participants with PD using this index showed a reliable decrease in activity in a number of regions, including the supplementary motor cortex, the mesial prefrontal cortex, the right middle frontal gyrus, and the left cerebellum (lobule VII/VIII) as well as increased activity in the right cerebellum (lobule IV/V). Using a cross validation approach we term "Reliability Mapping of Regional Differences" (RMRD) to analyze our sample, we were able to reliably distinguish participants with PD from controls with 92% sensitivity and 87% specificity. Our "pre-diagnostic" subject segregated in our analysis with the PD group. These results suggest that resting fMRI should be considered for development as a biomarker and analytical tool for evaluation of PD. PMID:21924367

  20. Exercise Effects on the Course of Gray Matter Changes Over 70 Days of Bed Rest

    Science.gov (United States)

    Koppelmans, V.; Ploutz-Snyder, L.; DeDios, Y. E.; Wood, S. J.; Reuter-Lorenz, P. A.; Kofman, I.; Bloomberg, J. J.; Mulavara, A. P.; Seidler, R. D.

    2014-01-01

    Long duration spaceflight affects posture control, locomotion, and manual control. The microgravity environment is an important causal factor for spaceflight induced sensorimotor changes through direct effects on peripheral changes that result from reduced vestibular stimulation and body unloading. Effects of microgravity on sensorimotor function have been investigated on earth using bed rest studies. Long duration bed rest serves as a space-flight analogue because it mimics microgravity in body unloading and bodily fluid shifts. It has been hypothesized that the cephalad fluid shift that has been observed in microgravity could potentially affect central nervous system function and structure, and thereby indirectly affect sensorimotor or cognitive functioning. Preliminary results of one of our ongoing studies indeed showed that 70 days of long duration head down-tilt bed rest results in focal changes in gray matter volume from pre-bed rest to various time points during bed rest. These gray matter changes that could reflect fluid shifts as well as neuroplasticity were related to decrements in motor skills such as maintenance of equilibrium. In consideration of the health and performance of crewmembers both inand post-flight we are currently conducting a study that investigates the potential preventive effects of exercise on gray matter and motor performance changes that we observed over the course of bed rest. Numerous studies have shown beneficial effects of aerobic exercise on brain structure and cognitive performance in healthy and demented subjects over a large age range. We therefore hypothesized that an exercise intervention in bed rest could potentially mitigate or prevent the effects of bed rest on the central nervous system. Here we present preliminary outcomes of our study.

  1. Impact Angle Control of Interplanetary Shock Geoeffectiveness

    CERN Document Server

    Oliveira, D M

    2015-01-01

    We use OpenGGCM global MHD simulations to study the nightside magnetospheric, magnetotail, and ionospheric responses to interplanetary (IP) fa st forward shocks. Three cases are presented in this study: two inclined oblique shocks, here after IOS-1 and IOS-2, where the latter has a Mach number twice stronger than the former. Both shocks have impact angles of 30$^o$ in relation to the Sun-Earth line. Lastly, we choose a frontal perpendicular shock, FPS, whose shock normal is along the Sun-Earth line, with the same Mach number as IOS-1. We find that, in the IOS-1 case, due to the north-south asymmetry, the magnetotail is deflected southward, leading to a mild compression. The geomagnetic activity observed in the nightside ionosphere is then weak. On the other hand, in the head-on case, the FPS compresses the magnetotail from both sides symmetrically. This compression triggers a substorm allowing a larger amount of stored energy in the magnetotail to be released to the nightside ionosphere, resulting in stronger...

  2. Analysis of Arterial Mechanics During Head-Down-Tilt Bed Rest

    Science.gov (United States)

    Elliott, Morgan B.; Martin, David S.; Westby, Christian M.; Stenger, Michael B.; Platts, Steven H.

    2014-01-01

    Carotid, brachial, and tibial arteries reacted differently to HDTBR. Previous studies have not analyzed the mechanical properties of the human brachial or anterior tibial arteries. After slight variations during bed-rest, arterial mechanical properties and IMT returned to pre-bed rest values, with the exception of tibial stiffness and PSE, which continued to be reduced post-bed rest while the DC remained elevated. The tibial artery remodeling was probably due to decreased pressure and volume. Resulting implications for longer duration spaceflight are unclear. Arterial health may be affected by microgravity, as shown by increased thoracic aorta stiffness in other ground based simulations (Aubert).

  3. Mapping of low flip angles in magnetic resonance

    Energy Technology Data Exchange (ETDEWEB)

    Balezeau, Fabien; Saint-Jalmes, Herve [LTSI, INSERM U642, Universite Rennes 1 (France); Eliat, Pierre-Antoine [PRISM, IFR 140, Universite Rennes 1 (France); Cayamo, Alejandro Bordelois, E-mail: fabien.balezeau@gmail.com [Centro De BiofIsika Medica, Universidad de Oriente, Santiago de Cuba (Cuba)

    2011-10-21

    Errors in the flip angle have to be corrected in many magnetic resonance imaging applications, especially for T1 quantification. However, the existing methods of B1 mapping fail to measure lower values of the flip angle despite the fact that these are extensively used in dynamic acquisition and 3D imaging. In this study, the nonlinearity of the radiofrequency (RF) transmit chain, especially for very low flip angles, is investigated and a simple method is proposed to accurately determine both the gain of the RF transmitter and the B1 field map for low flip angles. The method makes use of the spoiled gradient echo sequence with long repetition time (TR), such as applied in the double-angle method. It uses an image acquired with a flip angle of 90{sup 0} as a reference image that is robust to B1 inhomogeneity. The ratio of the image at flip angle alpha to the image at a flip angle of 90{sup 0} enables us to calculate the actual value of alpha. This study was carried out at 1.5 and 4.7 T, showing that the linearity of the RF supply system is highly dependent on the hardware. The method proposed here allows us to measure the flip angle from 1{sup 0} to 60{sup 0} with a maximal uncertainty of 10% and to correct T1 maps based on the variable flip angle method.

  4. Influence of small forms of active rest on intellection of students of agrarian higher institutes.

    Directory of Open Access Journals (Sweden)

    Prysjazhnuk S.I.

    2012-12-01

    Full Text Available Influence of facilities of active rest is considered on the increase of mental capacity of students. In research took part 105 students with the low level of physical preparedness. Progress of students is select the integral index of mental capacity. It is set that the most effective factors of diminishing of action of processes of fatigue and increase of mental capacity of students is the use of small forms of active rest during an educational day. It is suggested to utillize athletic pauses (minutes, micro pauses during the leadthrough of employments on theoretical disciplines. It is set that small forms of active rest in combination with a leadthrough independent health-improvement-trainings employments on physical self-perfection instrumental in the substantial improvement of the state of physical and mental capacity of student young people.

  5. Calculation of small angle multiple scattering and the application in proton beam tomography

    International Nuclear Information System (INIS)

    This paper discuss an expression for the determination of the multiple scattering angle when the energy loss is not considered, from the small angle multiple scattering. Also, it is discussed a correction for the standard formula of the multiple scattering angle presented by Rossi. The values of these correction factor were obtained for protons and alpha particles and heavy ions. These results show that the correction factor is important for protons and alpha particles, but irrelevant for heavy ions with mass number at the interval of 12 to 40 a mu. The angles of scattering angle and lateral displacement were calculated for a proton beam resting on on targets with homogeneous material such as water, which has great applicability for comparison with biological systems, wi the energy interval ranging from 180 to 250 MeV, which is the interest region for tomography with proton beams (pCT). From the results it became evident that for protons, the correction of energy in each space for gross targets must be considered. This work is part of a study which try perform a formalism for reconstruction of images obtained through a prototype of proton beam tomography

  6. Study of the advancing and receding contact angles: liquid sorption as a cause of contact angle hysteresis.

    Science.gov (United States)

    Lam, C N C; Wu, R; Li, D; Hair, M L; Neumann, A W

    2002-02-25

    Two types of experiments were used to study the behavior of both advancing and receding contact angles, namely the dynamic one-cycle contact angle (DOCA) and the dynamic cycling contact angle (DCCA) experiments. For the preliminary study, DOCA measurements of different liquids on different solids were performed using an automated axisymmetric drop shape analysis-profile (ADSA-P). From these experimental results, four patterns of receding contact angle were observed: (1) time-dependent receding contact angle; (2) constant receding contact angle; (3) 'stick/slip'; (4) no receding contact angle. For the purpose of illustration, results from four different solid surfaces are shown. These solids are: FC-732-coated surface; poly(methyl methacrylate/n-butyl methacrylate) [P(MMA/nBMA)]; poly(lactic acid) (DL-PLA); and poly(lactic/glycolic acid) 50/50 (DL-PLGA 50/50). Since most of the surfaces in our studies exhibit time dependence in the receding contact angle, a more extended study was conducted using only FC-732-coated surfaces to better understand the possible causes of decreasing receding contact angle and contact angle hysteresis. Contact angle measurements of 21 liquids from two homologous series (i.e. n-alkanes and 1-alcohols) and octamethylcyclotetrasiloxane (OCMTS) on FC-732-coated surfaces were performed. It is apparent that the contact angle hysteresis decreases with the chain length of the liquid. It was found that the receding contact angle equals the advancing angle when the alkane molecules are infinitely large. These results strongly suggest that the chain length and size of the liquid molecule could contribute to contact angle hysteresis phenomena. Furthermore, DCCA measurements of six liquids from the two homologous series on FC-732-coated surfaces were performed. With these experimental results, one can construe that the time dependence of contact angle hysteresis on relatively smooth and homogeneous surfaces is mainly caused by liquid retention

  7. VIBRATIONS OF A DEEP HEAVY FOUNDATION RESTING ON WEIGHTY MULTILAYER SOILS

    OpenAIRE

    Ter-Martirosyan Zaven Grigor'evich; Jaro Mokhammed Nazeem

    2012-01-01

    The authors present analytical and numerical solutions to the problem of vibrations of deep foundations caused by dynamic loads, if the foundations rest on multilayer soils. It is proven that the friction force that influences the foundation, the weighty nature of the bedding, and the visco-elastic properties of soils affect the amplitude and the frequency of vibrations. The authors present an approach to the calculation of vibrations of deep foundations resting on multilayer soils. The pr...

  8. Numerical aperture characteristics of angle-ended plastic optical fiber

    Science.gov (United States)

    Gao, Cheng; Farrell, Gerard

    2003-03-01

    With the increasing information rates demanded in consumer, automotive and aeronautical applications, a low cost and high performance physical transmission medium is required. Compared with Silica Optical Fiber, Plastic Optical Fiber (POF) offers an economic solution for a range of high-capacity, short-haul applications in industrial and military environments. Recently, a new type of POF, the perfluorinated graded-index plastic optical fiber (PF GI-POF), has been introduced that has low losses and high bandwidth at the communication wavelengths 850 nm and 1300nm. POF is normally terminated perpendicular to the fiber axis. We propose an angle-ended POF, which is terminated at non-perpendicular angles to the fiber axis. The aim of the research is to investigate the numerical aperture (NA) characteristics of angle-ended POF along the major axis of the elliptical endface. A theoretical model indicates that the NA of the angle-ended POF will increase nonlinearly with tilt-angle and the acceptance cone will be deflected with the angle of the deflection increasing nonlinearly with tilt-angle. We present results for the measured NA and the measured deflection angle using the far-field radiation method. Results are presented for 13 angle-ended SI-POF tilt-angles. We also present results for theoretical value of NA and deflection angle as a function of tilt-angle. The agreement between the measured and theoretical value is good up to tilt-angles of about 15 degrees, beyond which deviation occurs.

  9. Stop and revive? The effectiveness of nap and active rest breaks for reducing driver sleepiness.

    Science.gov (United States)

    Watling, Christopher N; Smith, Simon S; Horswill, Mark S

    2014-11-01

    The purpose of this study was to compare the effects of two commonly utilized sleepiness countermeasures: a nap break and an active rest break. The effects of the countermeasures were evaluated by physiological (EEG), subjective, and driving performance measures. Participants completed 2 h of simulated driving, followed by a 15-min nap break or a 15-min active rest break, then completed the final hour of simulated driving. The nap break reduced EEG and subjective sleepiness. The active rest break did not reduce EEG sleepiness, with sleepiness levels eventually increasing, and resulted in an immediate reduction of subjective sleepiness. No difference was found between the two breaks for the driving performance measure. The immediate reduction of subjective sleepiness after the active rest break could leave drivers with erroneous perceptions of their sleepiness, particularly with increases of physiological sleepiness after the break. PMID:24961384

  10. Profiling of REST-dependent microRNAs reveals dynamic modes of expression

    Directory of Open Access Journals (Sweden)

    Zhengliang eGao

    2012-05-01

    Full Text Available Multipotent neural stem cells (NSCs possess the ability to self-renew and differentiate into both neurons and glia. However, the detailed mechanisms underlying NSC fate decisions are not well understood. Recent work suggest that the interaction between cell-type specific transcription factors and microRNAs (miRNAs is important as resident neural stem/progenitor cells give rise to functionally mature neurons. Recently, we demonstrated that the transcriptional repressor REST (RE1-silencing transcription factor is essential to prevent precocious neuronal differentiation and maintain NSC self-renewal in the adult hippocampus. Here we show that REST is required for orchestrating the expression of distinct subsets of miRNAs in primary mouse NSC cultures, a physiologically relevant cell type. Using miRNA array profiling, we identified known REST-regulated miRNA genes, as well as previously uncharacterized REST-dependent miRNAs. Interestingly, REST-regulated miRNAs undergo dynamic expression changes under differentiation conditions over time, but not under proliferation conditions. These results suggest that REST functions in a context-dependent manner through its target miRNAs for mediating neuronal production.

  11. STUDY ON MIXIS POTENTIAL OF ROTIFER RESTING EGGS (BRACHIONUS PLICATILIS) WITH DIFFERENT COLLECTION TIMES AND DIFFERENT PRESERVATION PERIODS

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The present study investigated the possible changes in the mixis potential of rotifer resting eggs produced by a single stock of Brachionus plicatilis and collected and preserved annually from 1985-1998. Several clones derived from each batch of resting eggs were cultured under the same conditions for 21 days. The percentage of clones appearing resting eggs and the average yield of resting eggs produced from each clone were recorded and statistically analyzed to find the differences between the mixis potential of those resting egg batches. Results showed that different batches of resting eggs had different mictic levels among their descendent clones; but no regular relationship was found between the mixis potential of resting eggs and their collection times/preservation periods. Several internal and external factors that might affect the mixis potential of resting eggs were discussed.

  12. Progress in clinical research and application of resting state functional brain imaging

    International Nuclear Information System (INIS)

    Resting state functional brain imaging experimental design is free of stimulus task and offers various parametric maps through different data-driven post processing methods with endogenous BOLD signal changes as the source of imaging. Mechanism of resting state brain activities could be extensively studied with improved patient compliance and clinical application compared with task related functional brain imaging. Also resting state functional brain imaging can be used as a method of data acquisition, with implicit neuronal activity as a kind of experimental design, to reveal characteristic brain activities of epileptic patient. Even resting state functional brain imaging data processing method can be used to analyze task related functional MRI data, opening new horizons of task related functional MRI study. (authors)

  13. Topsoil as affected by dung deposition under resting places of red howler monkey (Alouatta seniculus)

    OpenAIRE

    Pouvelle, Sandrine; Feer, François; Ponge, Jean-François

    2008-01-01

    The short-term influence of dung deposition and the further redistribution of dung by dung beetles were studied under a resting place of the red howler monkey (Alouatta seniculus) living in tropical rainforests of South America. Monkey dung was experimentally clumped on the field in a place used by troops of howler monkeys for resting in the Nouragues Reserve Station, French Guiana. Dung-treated plots were sampled serially over three weeks and compared with controls located in their immediate...

  14. Proteome profiles of longissimus and biceps femoris porcine muscles related to exercise and resting

    DEFF Research Database (Denmark)

    F.W.Te Pas, Marinus; Keuning, Els; Van der Wiel, Dick J.M.; Young, Jette F; Oksbjerg, Niels; Kruijt, Leo

    2011-01-01

    Exercise affects muscle metabolism and composition in the untrained muscles. The proteome of muscle tissue will be affected by exercise and resting. This is of economic importance for pork quality where transportation relates to exercise of untrained muscles. Rest reverses exercise effects. The...... objective of this research was to develop potential protein biomarkers that predict the optimal resting time after exercise related to optimal pork quality. Ten litters of four female pigs were within litter allocated to the four treatment groups: exercise by running on a treadmill for 27 minutes followed...... by rest for 0, 1, or 3 h; control pigs without exercise. Proteome profiles and biochemical traits measuring energy metabolism and meat quality traits expected to be related to exercise were determined in the Longissimus and the Biceps femoris of the pigs. The results indicated associations between...

  15. Personality cannot be predicted from the power of resting state EEG

    Directory of Open Access Journals (Sweden)

    Kristjan Korjus

    2015-02-01

    Full Text Available In the present study we asked whether it is possible to decode personality traits from resting state EEG data. EEG was recorded from a large sample of subjects (n=289 who had answered questionnaires measuring personality trait scores of the 5 dimensions as well as the 10 subordinate aspects of the Big Five. Machine learning algorithms were used to build a classifier to predict each personality trait from power spectra of the resting state EEG data. The results indicate that the five dimensions as well as their subordinate aspects could not be predicted from the resting state EEG data. Finally, to demonstrate that this result is not due to systematic algorithmic or implementation mistakes the same methods were used to successfully classify whether the subject had eyes open or closed. These results indicate that the extraction of personality traits from the power spectra of resting state EEG is extremely noisy, if possible at all.

  16. EVALUATION OF NECK SHAFT ANGLE OF FEMUR ON DRY BONES

    OpenAIRE

    Radha; Ravi Shankar; Naveen; Roopa

    2015-01-01

    BACKGROUND: Evaluation of the neck shaft angle of femur helps to understand clinical relevance in bio mechanics of the hip joint. It helps for the better treatment of different pathological conditions of hip and femur and also to design prosthesis. Femoral neck shaft angle is important to convey the information regarding the race to ...

  17. Effects of proposed physical ballast tank treatments on aquatic invertebrate resting eggs.

    Science.gov (United States)

    Raikow, David F; Reid, David F; Blatchley, Ernest R; Jacobs, Gregory; Landrum, Peter F

    2007-04-01

    Adaptations in aquatic invertebrate resting eggs that confer protection from natural catastrophic events also could confer protection from treatments applied to ballast water for biological invasion vector management. To evaluate the potential efficacy of physical ballast water treatment methods, the present study examined the acute toxicity of heat (flash and holding methods), ultraviolet (UV) radiation (254 nm), and deoxygenation (acute and chronic) on resting eggs of the freshwater cladoceran Daphnia mendotae and the marine brine shrimp Artemia sp. Both D. mendotae and Artemia sp. were similarly sensitive to flash exposures of heat (100% mortality at 70 degrees C), but D. mendotae were much more sensitive to prolonged exposures. Exposure to 4,000 mJ/cm2 of UV radiation resulted in mortality rates of 59% in Artemia sp. and 91% in D. mendotae. Deoxygenation to an oxygen concentration of 1 mg/L was maximally toxic to both species. Deoxygenation suppressed hatching of D. mendotae resting eggs at oxygen concentrations of less than 5.5 mg/L and of Artemia sp. resting eggs at concentrations of less than 1 mg/L. Results suggest that UV radiation and deoxygenation are not viable treatment methods with respect to invertebrate resting eggs because of the impracticality of producing sufficient UV doses and the suppression of hatching at low oxygen concentrations. Results also suggest that the treatment temperatures required to kill resting eggs are much higher than those reported to be effective against other invertebrate life stages and species. The results, however, do not preclude the effectiveness of these treatments against other organisms or life stages. Nevertheless, if ballast tank treatment systems employing the tested methods are intended to include mitigation of viable resting eggs, then physical removal of large resting eggs and ephippia via filtration would be a necessary initial step. PMID:17447556

  18. A study of images of Projective Angles of pulmonary veins

    Energy Technology Data Exchange (ETDEWEB)

    Wang Jue [Beijing Anzhen Hospital, Beijing (China); Zhaoqi, Zhang [Beijing Anzhen Hospital, Beijing (China)], E-mail: zhaoqi5000@vip.sohu.com; Yu Wei; Miao Cuilian; Yan Zixu; Zhao Yike [Beijing Anzhen Hospital, Beijing (China)

    2009-09-15

    Aims: In images of magnetic resonance and computed tomography (CT) there are visible angles between pulmonary veins and the coronary, transversal or sagittal section of body. In this study these angles are measured and defined as Projective Angles of pulmonary veins. Several possible influential factors and characters of distribution are studied and analyzed for a better understanding of this imaging anatomic character of pulmonary veins. And it could be the anatomic base of adjusting correctly the angle of the central X-ray of the angiography of pulmonary veins undergoing the catheter ablation of atrial fibrillation (AF). Method: Images of contrast enhanced magnetic resonance angiography (CEMRA) and contrast enhanced computer tomography (CECT) of the left atrium and pulmonary veins of 137 health objects and patients with atrial fibrillation (AF) are processed with the technique of post-processing, and Projective Angles to the coronary and transversal sections are measured and analyzed statistically. Result: Project Angles of pulmonary veins are one of real and steady imaging anatomic characteristics of pulmonary veins. The statistical distribution of variables is relatively concentrated, with a fairly good representation of average value. It is possible to improve the angle of the central X-ray according to the average value in the selective angiography of pulmonary veins undergoing the catheter ablation of AF.

  19. EVALUATION OF NECK SHAFT ANGLE OF FEMUR ON DRY BONES

    Directory of Open Access Journals (Sweden)

    Radha

    2015-04-01

    Full Text Available BACKGROUND: Evaluation of the neck shaft angle of femur helps to understand clinical relevance in bio mechanics of the hip joint. It helps for the better treatment of different pathological conditions of hip and femur and also to design prosthesis. Femoral neck shaft angle is important to convey the information regarding the race to which they belong. Hence the present study was under taken to determine the neck shaft angle of femur in humans. OBJECTIVE: 1. To correct the different types of deformity and to have a normal good walking Mechanism. 2. To know the recent methodology and attempt to evaluate the range of normal Angles of femora and their sex differences. METHODS: ANTHROPOMETRIC: 100 Adult dry bones were studied and analyzed . The neck shaft angle of femur was measured by tracing outlines of contours of all femora. RESULTS: The neck shaft angle of the femur have revealed that there is no much difference in between males and females. There was slightly higher 0.2° in females. INTERPRETATION & CONCLUSION: There was no significant gender difference in neck shaft angle. The Knowledge of knowing the neck shaft angle helps to understand the Biomechanics of the hip joint and also for better treatment of pathological condition of hip and femur.

  20. Contact pressure distribution and support angle optimization of kiln tyre

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    According to the shearing force character and the deformation coordination condition of shell at the station of supports, the mathematical models to calculate contact angle and contact pressure distribution between tyre and shell were set up, the formulae of bending moment and bending stress of tyre were obtained. Taking the maximum of tyre fatigue life as the optimal objective, the optimization model of tyre support angle was built. The computational results show that when tyre support angle is 30°, tyre life is far less than that when tyre support angle is optimal, which is 35.6°, and it is unsuitable to stipulate tyre support angle to be 30° in traditional design. The larger the load, the less the nominal stress amplitude increment of tyre, the more favorable the tyre fatigue life when tyre support angle is optimal.

  1. Adrenergic regulation of lipolysis in situ at rest and during exercise.

    OpenAIRE

    Arner, P; Kriegholm, E; Engfeldt, P; Bolinder, J

    1990-01-01

    The adrenergic regulation of lipolysis was investigated in situ at rest and during standardized bicycle exercise in nonobese healthy subjects, using microdialysis of the extracellular space in subcutaneous adipose tissue. The glycerol concentration was about two times greater in adipose tissue than in venous blood. At rest, the glycerol concentration in adipose tissue was rapidly increased by 100% (P less than 0.01) after the addition of phentolamine to the ingoing perfusate, whereas addition...

  2. The Time Course of Task-Specific Memory Consolidation Effects in Resting State Networks

    OpenAIRE

    Sami, Saber; Edwin M Robertson; Miall, R. Chris

    2014-01-01

    Previous studies have reported functionally localized changes in resting-state brain activity following a short period of motor learning, but their relationship with memory consolidation and their dependence on the form of learning is unclear. We investigate these questions with implicit or explicit variants of the serial reaction time task (SRTT). fMRI resting-state functional connectivity was measured in human subjects before the tasks, and 0.1, 0.5, and 6 h after learning. There was signif...

  3. Elevation angle dependence of the SMA antenna focus position

    CERN Document Server

    Matsushita, S; Sakamoto, K; Hunter, T R; Patel, N A; Sridharan, T K; Wilson, R W; Matsushita, Satoki; Saito, Masao; Sakamoto, Kazushi; Hunter, Todd R.; Patel, Nimesh A.; Sridharan, Tirupati K.; Wilson, Robert W.

    2006-01-01

    We report the measurement results and compensation of the antenna elevation angle dependences of the Sub-millimeter Array (SMA) antenna characteristics. Without optimizing the subreflector (focus) positions as a function of the antenna elevation angle, antenna beam patterns show lopsided sidelobes, and antenna efficiencies show degradations. The sidelobe level increases and the antenna efficiencies decrease about 1% and a few %, respectively, for every 10 degrees change in the elevation angle at the measured frequency of 237 GHz. We therefore obtained the optimized subreflector positions for X (azimuth), Y (elevation), and Z (radio optics) focus axes at various elevation angles for all the eight SMA antennas. The X axis position does not depend on the elevation angle. The Y and Z axes positions depend on the elevation angles, and are well fitted with a simple function for each axis with including a gravity term (cosine and sine of elevation, respectively). In the optimized subreflector positions, the antenna ...

  4. Resting state alpha frequency is associated with menstrual cycle phase, estradiol and use of oral contraceptives

    OpenAIRE

    Brötzner, Christina P.; Klimesch, Wolfgang; Doppelmayr, Michael; Zauner, Andrea; Kerschbaum, Hubert H.

    2014-01-01

    Ongoing intrinsic brain activity in resting, but awake humans is dominated by alpha oscillations. In human, individual alpha frequency (IAF) is associated with cognitive performance. Noticeable, performance in cognitive and emotional tasks in women is associated with menstrual cycle phase and sex hormone levels, respectively. In the present study, we correlated frequency of alpha oscillation in resting women with menstrual cycle phase, sex hormone level, or use of oral contraceptives. Electro...

  5. Case of angina pectoris at rest and during effort due to coronary spasm and myocardial bridging

    OpenAIRE

    Teragawa, Hiroki; Fujii, Yuichi; Ueda, Tomohiro; Murata, Daiki; Nomura, Shuichi

    2015-01-01

    We present a case of a 71-year-old male who had chest symptoms at rest and during effort. He had felt chest oppression during effort for 1 year, and his chest symptoms had recently worsened. One month before admission he felt chest squeezing at rest in the early morning. He presented at our institution to evaluate his chest symptoms. Electrocardiography and echocardiography failed to show any specific changes. Because of the possibility that his chest symptoms were due to myocardial ischemia,...

  6. Replica Exchange with Solute Scaling: A more efficient version of Replica Exchange with Solute Tempering (REST2)

    OpenAIRE

    Wang, Lingle; Friesner, Richard A.; Berne, B. J.

    2011-01-01

    A small change in the Hamiltonian scaling in replica exchange with solute Tempering (REST) is found to improve its sampling efficiency greatly especially for the sampling of aqueous protein solutions in which there are large scale solute conformation changes. Like the original REST (REST1), the new version (which we call REST2) also bypasses the poor scaling with system size of the standard temperature replica exchange method (TREM), reducing the number of replicas (parallel processes) from w...

  7. The Influence of Roughness and Pyrethroid Formulations on Bed Bug (Cimex lectularius L. Resting Preferences

    Directory of Open Access Journals (Sweden)

    Benjamin A. Hottel

    2015-05-01

    Full Text Available Two-choice tests were conducted to examine the effect of surface roughness on the resting preference of bed bugs, Cimex lectularius L., on copper, basswood, and acrylic materials. The influence of pyrethroid formulation applications on resting preferences was also evaluated. Bed bugs were given the choice of resting between two sanded halves of each material tested. One half was sanded with a P60 grit sandpaper and the other with a less rough P600 grit sandpaper. A significantly higher proportion of bed bugs chose to rest on the rougher P60 grit sanded half of all materials tested. Pyrethroid applications were made to either the P60 grit half or both halves of acrylic arenas and resting preferences were again assessed. Behavioral responses of bed bugs to pyrethroid formulation applications varied depending on the bed bug strain used and the formulation applied. Bed bugs would still rest on the P60 grit half when Suspend SC formulation (0.06% deltamethrin was applied; however, an avoidance response was observed from a bed bug strain susceptible to D-Force aerosol formulations (0.06% deltamethrin. The avoidance behavior is likely attributed to one, more than one, or even an interaction of multiple spray constituents and not the active ingredient.

  8. DPARSF: a MATLAB toolbox for "pipeline" data analysis of resting-state fMRI

    Directory of Open Access Journals (Sweden)

    Chaogan Yan

    2010-05-01

    Full Text Available Resting-state functional magnetic resonance imaging (fMRI has attracted more and more attention because of its effectiveness, simplicity and non-invasiveness in exploration of the intrinsic functional architecture of the human brain. However, user-friendly toolbox for "pipeline" data analysis of resting-state fMRI is still lacking. Based on some functions in Statistical Parametric Mapping (SPM and Resting-State fMRI Data Analysis Toolkit (REST, we have developed a MATLAB toolbox called Data Processing Assistant for Resting-State fMRI (DPARSF for "pipeline" data analysis of resting-state fMRI. After the user arranges the DICOM files and click a few buttons to set parameters, DPARSF will then give all the preprocessed (slice timing, realign, normalize, smooth data and results for functional connectivity (FC, regional homogeneity (ReHo, amplitude of low-frequency fluctuation (ALFF, and fractional ALFF (fALFF. DPARSF can also create a report for excluding subjects with excessive head motion and generate a set of pictures for easily checking the effect of normalization. In addition, users can also use DPARSF to extract time courses from regions of interest.

  9. Effects of head-down-tilt bed rest on cerebral hemodynamics during orthostatic stress

    Science.gov (United States)

    Zhang, R.; Zuckerman, J. H.; Pawelczyk, J. A.; Levine, B. D.; Blomqvist, C. G. (Principal Investigator)

    1997-01-01

    Our aim was to determine whether the adaptation to simulated microgravity (microG) impairs regulation of cerebral blood flow (CBF) during orthostatic stress and contributes to orthostatic intolerance. Twelve healthy subjects (aged 24 +/- 5 yr) underwent 2 wk of -6 degrees head-down-tilt (HDT) bed rest to simulate hemodynamic changes that occur when humans are exposed to microG. CBF velocity in the middle cerebral artery (transcranial Doppler), blood pressure, cardiac output (acetylene rebreathing), and forearm blood flow were measured at each level of a ramped protocol of lower body negative pressure (LBNP; -15, -30, and -40 mmHg x 5 min, -50 mmHg x 3 min, then -10 mmHg every 3 min to presyncope) before and after bed rest. Orthostatic tolerance was assessed by using the cumulative stress index (CSI; mmHg x minutes) for the LBNP protocol. After bed rest, each individual's orthostatic tolerance was reduced, with the group CSI decreased by 24% associated with greater decreases in cardiac output and greater increases in systemic vascular resistance at each level of LBNP. Before bed rest, mean CBF velocity decreased by 14, 10, and 45% at -40 mmHg, -50 mmHg, and maximal LBNP, respectively. After bed rest, mean velocity decreased by 16% at -30 mmHg and by 21, 35, and 39% at -40 mmHg, -50 mmHg, and maximal LBNP, respectively. Compared with pre-bed rest, post-bed-rest mean velocity was less by 11, 10, and 21% at -30, -40, and -50 mmHg, respectively. However, there was no significant difference at maximal LBNP. We conclude that cerebral autoregulation during orthostatic stress is impaired by adaptation to simulated microG as evidenced by an earlier and greater fall in CBF velocity during LBNP. We speculate that impairment of cerebral autoregulation may contribute to the reduced orthostatic tolerance after bed rest.

  10. Comparison of Ocular Outcomes in Two 14-Day Bed Rest Studies

    Science.gov (United States)

    Cromwell, Ronita L.; Zanello, S. B.; Yarbough, P. O.; Tabbi, G.; Vizzeri, G.

    2012-01-01

    Reports of astronauts' visual changes have raised concern about ocular health during long-duration spaceflight. Some of these findings include globe flattening with hyperopic shifts, choroidal folds, optic disc edema, retinal nerve fiber layer (RNFL) thickening, and cotton wool spots. While the etiology remains unknown, it is hypothesized that, in predisposed individuals, hypertension in the brain may follow cephalad fluid shifts during spaceflight. This possible mechanism of ocular changes may also apply to analogous cases of idiopathic intracranial hypertension (IIH) or pseudotumor cerebri on Earth patients. Head-down t ilt (HDT) bed rest is a spaceflight analog that induces cephalad fluid shifts. Previous studies of the HDT position demonstrated body fluid shifts associated with changes in intraocular pressure (IOP) but the conditions of bed rest varied among experiments, making it difficult to compare data and draw conclusions. For these reasons, vision evaluation of bed rest subjects was implemented for NASA bed rest studies since 2010, in an attempt to monitor vision health in subjects subjected to bed rest. Vision monitoring is thus currently performed in all NASA-conducted bed rest campaigns

  11. The influence of rest period instructions on the default mode network

    Directory of Open Access Journals (Sweden)

    Christopher eBenjamin

    2010-12-01

    Full Text Available The default mode network (DMN refers to regional brain activity that is greater during rest periods than during attention-demanding tasks and many studies have reported DMN alterations in patient populations. It has also been shown that the DMN is suppressed by scanner background noise (SBN, which is the noise produced by functional magnetic resonance imaging (fMRI. However, it is unclear whether different approaches to rest in the noisy MR environment can alter the DMN and constitute a confound in studies investigating the DMN in particular patient populations (e.g., individuals with schizophrenia, Alzheimer’s disease. We examined twenty-seven healthy adult volunteers who completed an fMRI experiment with 3 different instructions for rest: (1 relax and be still, (2 attend to SBN, or (3 ignore SBN. Region of interest (ROI analyses were performed to determine the influence of rest period instructions on core regions of the DMN and DMN regions previously reported to be altered in patients with or at risk for Alzheimer’s disease or schizophrenia. The dorsal medial prefrontal cortex (dmPFC exhibited greater activity when specific resting instructions were given (i.e. attend to or ignore SBN compared to when non-specific resting instructions were given. Condition-related differences in connectivity were also observed between regions of the dmPFC and inferior parietal/posterior superior temporal cortex. We conclude that rest period instructions and SBN levels should be carefully considered for fMRI studies on the DMN, especially studies on clinical populations and groups that may have different approaches to rest, such as first-time research participants and children.

  12. Effects of a Resting Foot Splint in Early Brain Injury Patients

    OpenAIRE

    Sung, Eun Jung; Chun, Min Ho; Hong, Ja Young; Do, Kyung Hee

    2016-01-01

    Objective To assess the effectiveness of the resting foot splint to prevent ankle contracture. Methods We performed a randomized controlled trial in 33 patients with brain injury with ankle dorsiflexor weakness (muscle power ≤grade 2). Both groups continued conventional customized physical therapy, but the patients in the foot splint group were advised to wear a resting foot splint for more than 12 hours per day for 3 weeks. The data were assessed before and 3 weeks after the study. The prima...

  13. Predictive Modeling of Spinner Dolphin (Stenella longirostris) Resting Habitat in the Main Hawaiian Islands

    OpenAIRE

    Thorne, Lesley H.; Johnston, David W; Dean L. Urban; Julian Tyne; Lars Bejder; Baird, Robin W; Suzanne Yin; Susan H Rickards; Deakos, Mark H.; Mobley, Joseph R.; Pack, Adam A; Marie Chapla Hill

    2012-01-01

    Predictive habitat models can provide critical information that is necessary in many conservation applications. Using Maximum Entropy modeling, we characterized habitat relationships and generated spatial predictions of spinner dolphin (Stenella longirostris) resting habitat in the main Hawaiian Islands. Spinner dolphins in Hawai'i exhibit predictable daily movements, using inshore bays as resting habitat during daylight hours and foraging in offshore waters at night. There are growing concer...

  14. Visual Learning Alters the Spontaneous Activity of the Resting Human Brain: An fNIRS Study

    OpenAIRE

    Haijing Niu; Hao Li; Li Sun; Yongming Su; Jing Huang; Yan Song

    2014-01-01

    Resting-state functional connectivity (RSFC) has been widely used to investigate spontaneous brain activity that exhibits correlated fluctuations. RSFC has been found to be changed along the developmental course and after learning. Here, we investigated whether and how visual learning modified the resting oxygenated hemoglobin (HbO) functional brain connectivity by using functional near-infrared spectroscopy (fNIRS). We demonstrate that after five days of training on an orientation discrimina...

  15. Predictors of Postoperative Movement and Resting Pain following Total Knee Replacement

    OpenAIRE

    Rakel, Barbara A.; Blodgett, Nicole Petsas; Zimmerman, M. Bridget; Logsden-Sackett, Nyla; Clark, Charles; Noiseux, Nicolas; Callaghan, John; Herr, Keela; Geasland, Katharine; Yang, Xiaoyan; Sluka, Kathleen A

    2012-01-01

    This study determined preoperative predictors of movement and resting pain following total knee replacement (TKR). We hypothesized that younger patients with higher preoperative pain intensity, pain sensitivity, trait anxiety, pain catastrophizing, and depression would be more likely to experience higher postoperative movement pain than older patients with lower scores on these variables prior to surgery and that predictors would be similar for resting pain. Demographics, analgesic intake, an...

  16. Modulation of the COMT Val158Met polymorphism on resting-state EEG power

    OpenAIRE

    Silvia Solis-Ortiz; Mayra Gutierrez-Muñoz

    2015-01-01

    The catechol-O-methyltransferase (COMT) Val158Met polymorphism impacts cortical dopamine (DA) levels and may influence cortical electrical activity in the human brain. This study investigated whether COMT genotype influences resting-state electroencephalogram (EEG) power in the frontal, parietal and midline regions in healthy volunteers. EEG recordings were conducted in the resting-state in 13 postmenopausal healthy woman carriers of the Val/Val genotype and 11 with the Met/Met genotype. The ...

  17. Rotational Angle Measurement of Bridge Support Using Image Processing Techniques

    OpenAIRE

    Young-Soo Park; John Arbie Agbayani; Jong-Han Lee; Jong-Jae Lee

    2016-01-01

    Measuring a very small rotational angle accurately and dynamically is indeed a challenging issue, especially in the case of bridge support. Also, existing inclinometers do not have sufficient resolution and accuracy to measure a bridge’s rotational angle. In this study, a new measurement system was developed to provide a practical means for measuring dynamic rotational angle of a bridge support. It features high resolution and accuracy compared with the available systems on the market. By the...

  18. Orientation angle and the adhesion of single gecko setae

    OpenAIRE

    Hill, Ginel C.; Soto, Daniel R.; Peattie, Anne M.; Full, Robert J.; Kenny, T. W.

    2011-01-01

    We investigated the effects of orientation angle on the adhesion of single gecko setae using dual-axis microelectromechanical systems force sensors to simultaneously detect normal and shear force components. Adhesion was highly sensitive to the pitch angle between the substrate and the seta's stalk. Maximum lateral adhesive force was observed with the stalk parallel to the substrate, and adhesion decreased smoothly with increasing pitch. The roll orientation angle only needed to be roughly co...

  19. Lateral intermetatarsal angle: a useful measurement of metatarsus primus elevatus?

    Science.gov (United States)

    Bryant, A; Mahoney, B; Tinley, P

    2001-05-01

    The lateral intermetatarsal angle, a measurement of the sagittal plane angular divergence between the dorsal cortices of the first and second metatarsals of lateral weightbearing foot radiographs, was compared in 30 normal and 30 hallux limitus feet. The results suggest that the angle may be measured reliably and that although the measured angles are relatively small, a significant difference exists between the normal and hallux limitus subjects studied. Accordingly, the lateral intermetatarsal angle may prove to be a useful radiographic measurement to assist the podiatric physician in the clinical assessment of hallux limitus. PMID:11359890

  20. NEW ESTIMATES OF THE INCLINATION, POSITION ANGLE, PITCH ANGLE, AND SCALE HEIGHT OF THE WHIRLPOOL GALAXY

    Energy Technology Data Exchange (ETDEWEB)

    Hu Tao [Department of Automation, Shanghai University, 149 Yanchang Rd., Shanghai 200072 (China); Shao Zhengyi [Shanghai Astronomical Observatory, Chinese Academy of Sciences, 80 Nandan Rd., Shanghai 200030 (China); Peng Qiuhe, E-mail: thu@shu.edu.cn, E-mail: taohu.nju@gmail.com [Department of Astronomy, Nanjing University, 22 Hankou Rd., Nanjing 210093 (China)

    2013-01-10

    The inclination (i) and position angle (PA) of the Whirlpool galaxy (M51) are critical to modeling and interpreting observations. Here we make improved estimates of these parameters by fitting logarithmic spirals to the main arms. From separate fits to each major arm, we obtain i = 20. Degree-Sign 3 {+-} 2. Degree-Sign 8 and PA = 12. Degree-Sign 0 {+-} 2. Degree-Sign 5. We then use Poisson's equation for the logarithmic perturbation of the density to estimate the mean vertical scale height (H) of M51 to be 95-178 pc.

  1. Six-Degree Head-Down Tilt Bed Rest: Forty Years of Development as a Physiological Analog for Weightlessness

    Science.gov (United States)

    Smith, Jeffrey D.; Cromwell, Ronita L.; Kundrot, Craig E.; Charles, John B.

    2011-01-01

    Early on, bed rest was recognized as a method for inducing many of the physiological changes experienced by spaceflight. Head-down tilt (HDT) bed rest was first introduced as an analog for spaceflight by a Soviet team led by Genin and Kakurin. Their study was performed in 1970 (at -4 degrees) and lasted for 30 days; results were reported in the Russian Journal of Space Biology (Kosmicheskaya Biol. 1972; 6(4): 26-28 & 45-109). The goal was to test physiological countermeasures for cosmonauts who would soon begin month-long missions to the Salyut space station. HDT was chosen to produce a similar sensation of blood flow to the head reported by Soyuz cosmonauts. Over the next decade, other tilt angles were studied and comparisons with spaceflight were made, showing that HDT greater than 4 degrees was superior to horizontal bed rest for modeling acute physiological changes observed in space; but, at higher angles, subjects experienced greater discomfort without clearly improving the physiological comparison to spaceflight. A joint study performed by US and Soviet investigators, in 1979, set the goal of standardization of baseline conditions and chose 6-degrees HDT. This effectively established 6-degree HDT bed rest as the internationally-preferred analog for weightlessness and, since 1990, nearly all further studies have been conducted at 6-degrees HDT. A thorough literature review (1970-2010) revealed 534 primary scientific journal articles which reported results from using HDT as a physiological analog for spaceflight. These studies have ranged from as little as 10 minutes to the longest duration of 370 days. Long-term studies lasting four weeks or more have resulted in over 170 primary research articles. Today, the 6-degree HDT model provides a consistent, thoroughly-tested, ground-based analog for spaceflight and allows the proper scientific controls for rigorous testing of physiological countermeasures; however, all models have their strengths and limits. The 6

  2. Comparison of Ocular Outcomes in Two 14-Day Bed Rest Studies

    Science.gov (United States)

    Cromwell, R. L.; Zanello, S. B.; Yarbough, P. O.; Taibbi, G.; Vizzeri, G.

    2011-01-01

    Reports of astronauts visual changes raised concern about ocular health during long-duration spaceflight. Some of these findings included hyperopic shifts, choroidal folds, optic disc edema, retinal nerve fiber layer (RNFL) thickening, and cotton wool spots. While the etiology remains unknown, hypotheses speculate that hypertension in the brain caused by cephalad fluid shifts during spaceflight is a possible mechanism for these ocular changes. Head-down tilt (HDT) bed rest is a spaceflight analog that induces cephalad fluid shifts. In addition, previous studies of the HDT position demonstrated body fluid shifts associated with changes in intraocular pressure (IOP). For these reasons, vision monitoring of HDT bed rest subjects was implemented for NASA bed rest studies. Subjects selected for these studies were healthy adults (14 males and 5 females). Average age was 37.5 plus or minus 9.1 years, weight was 77.4 plus or minus 11.3 Kg, and height was 173.4 plus or minus 7.2 14 cm. Controlled conditions followed for all NASA bed rest studies were implemented. These conditions included factors such as eating a standardized diet, maintaining a strict sleep wake cycle, and remaining in bed for 24 hours each day. In one study, subjects maintained a horizontal (0 degree) position while in bed and were exercised six days per week with an integrated resistance and aerobic training (iRAT) program. In the other study, subjects were placed at 6 degrees HDT while in bed and did not engage in exercise. All subjects underwent pre- and post bed rest vision testing. While the battery of vision tests for each study was not identical, measures common to both studies will be presented. These measures included IOP and measures that provided an indication of optic disc swelling as derived from optical coherence tomography (OCT) testing: average retinal nerve fiber layer (RNFL) thickness (millimeters), disc area (square millimeters), rim area (square millimters), and average cup to disc (C

  3. Attenuation corrected stress myocardial SPECT: possibility of reduction in number of rest investigation

    International Nuclear Information System (INIS)

    Attenuation-corrected (AC) imaging frequently shows normal stress myocardial perfusion while non-corrected (NC) imaging shows hypoperfusion. The aim of the work was to assess whether it is necessary to continue with resting examination in this situation. 121 consecutive patients had positive finding at AC and/or NC sestamibi stress myocardial imaging using E.CAM Profile system and resting examination was carried out. AC stress imaging was normal while NC imaging showed hypoperfusion in 29 cases. In one case this finding was reversed. In this group of 30 patients with AC/NC stress discrepancies, resting examination has not revealed any additional information in 28 cases. In 2 cases NC imaging, in contrast to AC, showed stress ischaemia. In one of these 2 cases coronarography was carried out with negative result. In the other case patient refused coronarography. The resting examination did not bring any benefits in 29-30 cases out of 30 (96.7 to 100.0%) patients with AC/NC stress discrepancies. If the results of this study are considered accordingly, in our group approximately one fourth of the resting examinations (29 to 30 out of 121) could be saved. (author)

  4. Brocard angle of the standard triangle in an isotropic plane

    OpenAIRE

    Kolar-Begović, Zdenka; Kolar - Šuper, Ružica; Volenec, Vladimir

    2009-01-01

    The concept of Brocard angle of the standard triangle in an isotropic plane I2 is introduced. The relationships between Brocard angles of the allowable triangle and circum-Ceva’s triangle of its centroid and circum-Ceva’s triangle of its Feuerbach point are investigated.

  5. 46 CFR 58.01-40 - Machinery, angles of inclination.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Machinery, angles of inclination. 58.01-40 Section 58.01... AUXILIARY MACHINERY AND RELATED SYSTEMS General Requirements § 58.01-40 Machinery, angles of inclination. (a) Propulsion machinery and all auxiliary machinery essential to the propulsion and safety of the vessel must...

  6. Is functional integration of resting state brain networks an unspecific biomarker for working memory performance?

    Science.gov (United States)

    Alavash, Mohsen; Doebler, Philipp; Holling, Heinz; Thiel, Christiane M; Gießing, Carsten

    2015-03-01

    Is there one optimal topology of functional brain networks at rest from which our cognitive performance would profit? Previous studies suggest that functional integration of resting state brain networks is an important biomarker for cognitive performance. However, it is still unknown whether higher network integration is an unspecific predictor for good cognitive performance or, alternatively, whether specific network organization during rest predicts only specific cognitive abilities. Here, we investigated the relationship between network integration at rest and cognitive performance using two tasks that measured different aspects of working memory; one task assessed visual-spatial and the other numerical working memory. Network clustering, modularity and efficiency were computed to capture network integration on different levels of network organization, and to statistically compare their correlations with the performance in each working memory test. The results revealed that each working memory aspect profits from a different resting state topology, and the tests showed significantly different correlations with each of the measures of network integration. While higher global network integration and modularity predicted significantly better performance in visual-spatial working memory, both measures showed no significant correlation with numerical working memory performance. In contrast, numerical working memory was superior in subjects with highly clustered brain networks, predominantly in the intraparietal sulcus, a core brain region of the working memory network. Our findings suggest that a specific balance between local and global functional integration of resting state brain networks facilitates special aspects of cognitive performance. In the context of working memory, while visual-spatial performance is facilitated by globally integrated functional resting state brain networks, numerical working memory profits from increased capacities for local processing

  7. RESTful Web Services Cookbook

    CERN Document Server

    Allamaraju, Subbu

    2010-01-01

    While the REST design philosophy has captured the imagination of web and enterprise developers alike, using this approach to develop real web services is no picnic. This cookbook includes more than 100 recipes to help you take advantage of REST, HTTP, and the infrastructure of the Web. You'll learn ways to design RESTful web services for client and server applications that meet performance, scalability, reliability, and security goals, no matter what programming language and development framework you use. Each recipe includes one or two problem statements, with easy-to-follow, step-by-step i

  8. [Double measurement of the Böhler angle: prognostic value of radiological angles in posterior facet fractures of the calcaneus].

    Science.gov (United States)

    Chaminade, B; Zographos, S; Uthéza, G

    2001-11-01

    In 1931, Böhler proposed that measuring the radiological angle of the tuberosity could be useful in posterior facet fractures of the calcaneus to evaluate initial damage as well as reduction quality. In opposition to the 1998 SOFCOT symposium, certain authors considered that the Böhler angle has no prognostic value. Progress in pathological anatomy has helped to better understand posterior facet fractures, justifying the use of a "double measurement". The fundamental fracture line separates the posterior facet into a lowered medial fragment and a pivoted lateral fragment. The double contour of the posterior facet visualized radiographically allows measurement of a medial Böhler angle and a lateral Böhler angle. It is demonstrated that is the smaller the medial Böhler angle, the greater the subtalar degeneration. Surgical restoration of a satisfactory Böhler angle is a necessary prerequisite for a good outcome. "Double measurement" of the Böhler angle on the lateral view contributes to the prognostic value of this historical angle. PMID:11845075

  9. The effect of knee joint angle on torque control.

    Science.gov (United States)

    Sosnoff, Jacob J; Voudrie, Stefani J; Ebersole, Kyle T

    2010-01-01

    The purpose of the author's investigation was to examine the effect of knee joint angle on torque control of the quadriceps muscle group. In all, 12 healthy adults produced maximal voluntary contractions and submaximal torque (15, 30, and 45% MVC [maximal voluntary contraction]) at leg flexion angles of 15 degrees , 30 degrees , 60 degrees , and 90 degrees below the horizontal plane. As expected, MVC values changed with respect to joint angle with maximum torque output being greatest at 60 degrees and least at 15 degrees . During the submaximal tasks, participants appropriately scaled their torque output to the required targets. Absolute variability (i.e., standard deviation) of torque output was greatest at 60 degrees and 90 degrees knee flexion. However, relative variability as indexed by coefficient of variation (CV) decreased as joint angle increased, with the greatest CV occurring at 15 degrees . These results are congruent with the hypothesis that joint angle influences the control of torque. PMID:19906637

  10. EFFECT OF SWEEP ANGLE ON THE VORTICAL FLOW OVER DELTA WINGS AT AN ANGLE OF ATTACK OF 10°

    Directory of Open Access Journals (Sweden)

    JAMES BRETT

    2014-12-01

    Full Text Available CFD simulations have been used to analyse the vortical flows over sharp edged delta wings with differing sweep angles under subsonic conditions at an angle of attack of 10°. RANS simulations were validated against experimental data for a 65° sweep wing, with a flat cross-section, and the steadiness of the flow field was assessed by comparing the results against unsteady URANS and DES simulations. To assess the effect of sweep angle on the flow field, a range of sweep angles from 65° to 43° were simulated. For moderate sweep wings the primary vortex was observed to detach from the leading edge, undergoing vortex breakdown, and a weaker, replacement, "shadow" vortex was formed. The shadow vortex was observed for sweep angles of 50° and less, and resulted in reduced lift production near the wing tips loss of the stronger primary vortex.

  11. Automatic registration and alignment on a template of cardiac stress and rest reoriented SPECT images.

    Science.gov (United States)

    Declerck, J; Feldmar, J; Goris, M L; Betting, F

    1997-12-01

    Single photon emission computed tomography (SPECT) imaging with 201Tl or 99mTc agent is used to assess the location or the extent of myocardial infarction or ischemia. A method is proposed to decrease the effect of operator variability in the visual or quantitative interpretation of scintigraphic myocardial perfusion studies. To effect this, the patient's myocardial images (target cases) are registered automatically over a template image, utilizing a nonrigid transformation. The intermediate steps are: 1) Extraction of feature points in both stress and rest three-dimensional (3-D) images. The images are resampled in a polar geometry to detect edge points, which in turn are filtered by the use of a priori constraints. The remaining feature points are assumed to be points on the edges of the left ventricular myocardium. 2) Registration of stress and rest images with a global affine transformation. The matching method is an adaptation of the iterative closest point algorithm. 3) Registration and morphological matching of both stress and rest images on a template using a nonrigid local spline transformation following a global affine transformation. 4) Resampling of both stress and rest images in the geometry of the template. Optimization of the method was performed on a database of 40 pairs of stress and rest images selected to obtain a wide variation of images and abnormalities. Further testing was performed on 250 cases selected from the same database on the basis of the availability of angiographic results and patient stratification. PMID:9533574

  12. Functional connectivity dynamics: modeling the switching behavior of the resting state.

    Science.gov (United States)

    Hansen, Enrique C A; Battaglia, Demian; Spiegler, Andreas; Deco, Gustavo; Jirsa, Viktor K

    2015-01-15

    Functional connectivity (FC) sheds light on the interactions between different brain regions. Besides basic research, it is clinically relevant for applications in Alzheimer's disease, schizophrenia, presurgical planning, epilepsy, and traumatic brain injury. Simulations of whole-brain mean-field computational models with realistic connectivity determined by tractography studies enable us to reproduce with accuracy aspects of average FC in the resting state. Most computational studies, however, did not address the prominent non-stationarity in resting state FC, which may result in large intra- and inter-subject variability and thus preclude an accurate individual predictability. Here we show that this non-stationarity reveals a rich structure, characterized by rapid transitions switching between a few discrete FC states. We also show that computational models optimized to fit time-averaged FC do not reproduce these spontaneous state transitions and, thus, are not qualitatively superior to simplified linear stochastic models, which account for the effects of structure alone. We then demonstrate that a slight enhancement of the non-linearity of the network nodes is sufficient to broaden the repertoire of possible network behaviors, leading to modes of fluctuations, reminiscent of some of the most frequently observed Resting State Networks. Because of the noise-driven exploration of this repertoire, the dynamics of FC qualitatively change now and display non-stationary switching similar to empirical resting state recordings (Functional Connectivity Dynamics (FCD)). Thus FCD bear promise to serve as a better biomarker of resting state neural activity and of its pathologic alterations. PMID:25462790

  13. Systematic reviews of bed rest and advice to stay active for acute low back pain.

    Science.gov (United States)

    Waddell, G; Feder, G; Lewis, M

    1997-01-01

    BACKGROUND: In the United Kingdom (UK), 9% of adults consult their doctor annually with back pain. The treatment recommendations are based on orthopaedic teaching, but the current management is causing increasing dissatisfaction. Many general practitioners (GPs) are confused about what constitutes effective advice. AIM: To review all randomized controlled trials of bed rest and of medical advice to stay active for acute back pain. METHOD: A systematic review based on a search of MEDLINE and EMBASE from 1966 to April 1996 with complete citation tracking for randomized controlled trials of bed rest or medical advice to stay active and continue ordinary daily activities. The inclusion criteria were: primary care setting, patients with low back pain of up to 3 months duration, and patient-centred outcomes (rate of recovery from the acute attack, relief of pain, restoration of function, satisfaction with treatment, days off work and return to work, development of chronic pain and disability, recurrent attacks, and further health care use). RESULTS: Ten trials of bed rest and eight trials of advice to stay active were identified. Consistent findings showed that bed rest is not an effective treatment for acute low back pain but may delay recovery. Advice to stay active and to continue ordinary activities results in a faster return to work, less chronic disability, and fewer recurrent problems. CONCLUSION: A simple but fundamental change from the traditional prescription of bed rest to positive advice about staying active could improve clinical outcomes and reduce the personal and social impact of back pain. PMID:9474831

  14. Drop Size Dependence of the Contact Angle of Nanodroplets

    Institute of Scientific and Technical Information of China (English)

    GUO Hong-Kai; FANG Hai-Ping

    2005-01-01

    @@ The contact angle of nanosized non-polarized argon sessile droplets on a solid substrate is studied by using molecular dynamics simulations.It is found that the drop size dependence of the contact angle is sensitive to the interaction between the liquid molecules and solid molecules.The contact angle decreases with the decreasing drop size for larger interaction between the liquid molecules and the solid substrate, and vice versa.This observation is consistent with most of the previous theoretical and experimental results.

  15. An overview of the issues: physiological effects of bed rest and restricted physical activity

    Science.gov (United States)

    Convertino, V. A.; Bloomfield, S. A.; Greenleaf, J. E.

    1997-01-01

    Reduction of exercise capacity with confinement to bed rest is well recognized. Underlying physiological mechanisms include dramatic reductions in maximal stroke volume, cardiac output, and oxygen uptake. However, bed rest by itself does not appear to contribute to cardiac dysfunction. Increased muscle fatigue is associated with reduced muscle blood flow, red cell volume, capillarization and oxidative enzymes. Loss of muscle mass and bone density may be reflected by reduced muscle strength and higher risk for injury to bones and joints. The resultant deconditioning caused by bed rest can be independent of the primary disease and physically debilitating in patients who attempt to reambulate to normal active living and working. A challenge to clinicians and health care specialists has been the identification of appropriate and effective methods to restore physical capacity of patients during or after restricted physical activity associated with prolonged bed rest. The examination of physiological responses to bed rest deconditioning and exercise training in healthy subjects has provided significant information to develop effective rehabilitation treatments. The successful application of acute exercise to enhance orthostatic stability, daily endurance exercise to maintain aerobic capacity, or specific resistance exercises to maintain musculoskeletal integrity rather than the use of surgical, pharmacological, and other medical treatments for clinical conditions has been enhanced by investigation and understanding of underlying mechanisms that distinguish physical deconditioning from the disease. This symposium presents an overview of cardiovascular and musculoskeletal deconditioning associated with reduced physical work capacity following prolonged bed rest and exercise training regimens that have proven successful in ameliorating or reversing these adverse effects.

  16. Pilot crossover trial of Reiki versus rest for treating cancer-related fatigue.

    Science.gov (United States)

    Tsang, Kathy L; Carlson, Linda E; Olson, Karin

    2007-03-01

    Fatigue is an extremely common side effect experienced during cancer treatment and recovery. Limited research has investigated strategies stemming from complementary and alternative medicine to reduce cancer-related fatigue. This research examined the effects of Reiki, a type of energy touch therapy, on fatigue, pain, anxiety, and overall quality of life. This study was a counterbalanced crossover trial of 2 conditions: (1) in the Reiki condition, participants received Reiki for 5 consecutive daily sessions, followed by a 1-week washout monitoring period of no treatments, then 2 additional Reiki sessions, and finally 2 weeks of no treatments, and (2) in the rest condition, participants rested for approximately 1 hour each day for 5 consecutive days, followed by a 1-week washout monitoring period of no scheduled resting and an additional week of no treatments. In both conditions, participants completed questionnaires investigating cancer-related fatigue (Functional Assessment of Cancer Therapy Fatigue subscale [FACT-F]) and overall quality of life (Functional Assessment of Cancer Therapy, General Version [FACT-G]) before and after all Reiki or resting sessions. They also completed a visual analog scale (Edmonton Symptom Assessment System [ESAS]) assessing daily tiredness, pain, and anxiety before and after each session of Reiki or rest. Sixteen patients (13 women) participated in the trial: 8 were randomized to each order of conditions (Reiki then rest; rest then Reiki). They were screened for fatigue on the ESAS tiredness item, and those scoring greater than 3 on the 0 to 10 scale were eligible for the study. They were diagnosed with a variety of cancers, most commonly colorectal (62.5%) cancer, and had a median age of 59 years. Fatigue on the FACT-F decreased within the Reiki condition (P=.05) over the course of all 7 treatments. In addition, participants in the Reiki condition experienced significant improvements in quality of life (FACT-G) compared to those in

  17. Stable divergence angles of a magnetic dipole spiral array

    Energy Technology Data Exchange (ETDEWEB)

    Fan, X.D.; Bursill, L.A.

    1996-03-01

    An analytical model is introduced for Douady and Couder`s [1992] experiment, where phyllotactic patterns appear as a dynamical result of the interaction between magnetic dipoles. The difference equation for the divergence angle (i.e. the angle between successive radial vectors) is obtained by solving the equations of motion with a second nearest neighbour (SNN) approximation. A one dimensional map analysis as well as a comprehensive analytical proof shows that the divergence angle always converges to a single attractor regardless of the initial conditions. This attractor is approximately the Fibonacci angle ({approx} 138 deg) within variations due to a growth factor {mu} of the pattern. The system is proved to be stable with the SNN approximation. Further analysis with a third nearest neighbour approximation (TNN) shows extra linearly stable attractors may appear around the Lucas angle at {approx} 99.5 deg. 7 refs., 5 figs.

  18. [The sulcus angle of the femoral trochlea: ultrasonographic evaluation].

    Science.gov (United States)

    Martino, F; De Serio, A; Macarini, L; Colaianni, P; Solarino, M; Fracella, M R

    1995-03-01

    The sulcus angle of femoral trochlea is particularly important to evaluate the femoro-patellar joint. Our study was aimed at studying the normal trochlea, and especially the sulcus angle, with US. The right knees of 11 normal subjects were examined with US and Computed Tomography (CT) on the same section planes. The US measurements of the sulcus angle were correlated with CT results, which were considered the gold standard. The US and CT data were compared and a direct correlation was found (r = 0.832). The intraobserver difference in US measurements was r = 0.943. The mean sulcus angle value was 132 degrees, in agreement with literature data. We conclude that the US measurements of the sulcus angle are reproducible and as sensitive as CT. PMID:7754110

  19. Effects of capsinoid ingestion on energy expenditure and lipid oxidation at rest and during exercise

    Directory of Open Access Journals (Sweden)

    Staples Aaron W

    2010-08-01

    Full Text Available Abstract Background The thermogenic and metabolic properties of capsinoids appear to mimic those of the more pungent sister compound capsaicin. However, few data exist on how capsinoid ingestion affects energy expenditure in humans and no data exist on its interaction with exercise. We aimed to determine how ingestion of capsinoids affected energy expenditure, lipid oxidation and blood metabolites at rest and during moderate intensity exercise. Methods Twelve healthy young men (age = 24.3 ± 3 yr, BMI = 25.5 ± 1.7 kg·m-2 were studied on two occasions in a double-blind design following ingestion of either placebo or 10 mg of purified capsinoids at rest, after 90 min of cycling at 55% VO2 peak, and for 30 min into recovery. Subjects ingested the capsules 30 min prior to exercise. Results At rest, following ingestion of capsinoids, we observed increases in VO2 and plasma norepinephrine levels, and decreases in concentrations of serum free fatty acids, plasma glycerol and the respiratory exchange ratio (all P Conclusion The ingestion of 10 mg of capsinoids increased adrenergic activity, energy expenditure, and resulted in a shift in substrate utilization toward lipid at rest but had little effect during exercise or recovery. The changes we observed confirm previous data on the thermogenic and metabolic effects of capsinoids at rest and further promote its potential role as an adjunct weight loss aid, in addition to diet and exercise.

  20. Differential atrophy of the lower-limb musculature during prolonged bed-rest.

    Science.gov (United States)

    Belavý, Daniel L; Miokovic, Tanja; Armbrecht, Gabriele; Richardson, Carolyn A; Rittweger, Jörn; Felsenberg, Dieter

    2009-11-01

    Patients with medical, orthopaedic and surgical conditions are often assigned to bed-rest and/or immobilised in orthopaedic devices. Although such conditions lead to muscle atrophy, no studies have yet considered differential atrophy of the lower-limb musculature during inactivity to enable the development of rehabilitative exercise programmes. Bed-rest is a model used to simulate the effects of spaceflight and physical inactivity. Ten male subjects underwent 56-days of bed-rest. Magnetic resonance imaging of the lower-limbs was performed at 2-weekly intervals during bed-rest. Volume of individual muscles of the lower-limb and subsequently, rates of atrophy were calculated. Rates of atrophy differed (F = 7.4, p 0.081). Differential rates of atrophy were seen in synergistic muscles (e.g. adductor magnus > adductor longus, p = 0.009; medial gastrocnemius > lateral gastrocnemius, p = 0.002; vastii > rectus femoris, p = 0.0002). These results demonstrate that muscle imbalances can occur after extended periods of reduced postural muscle activity, potentially hampering recovery on return to full upright body position. Such deconditioned patients should be prescribed "closed-chain" simulated resistance exercises, which target the lower-limb antigravity extensor muscles which were most affected in bed-rest. PMID:19680682

  1. Automatic classification of schizophrenia using resting-state functional language network via an adaptive learning algorithm

    Science.gov (United States)

    Zhu, Maohu; Jie, Nanfeng; Jiang, Tianzi

    2014-03-01

    A reliable and precise classification of schizophrenia is significant for its diagnosis and treatment of schizophrenia. Functional magnetic resonance imaging (fMRI) is a novel tool increasingly used in schizophrenia research. Recent advances in statistical learning theory have led to applying pattern classification algorithms to access the diagnostic value of functional brain networks, discovered from resting state fMRI data. The aim of this study was to propose an adaptive learning algorithm to distinguish schizophrenia patients from normal controls using resting-state functional language network. Furthermore, here the classification of schizophrenia was regarded as a sample selection problem where a sparse subset of samples was chosen from the labeled training set. Using these selected samples, which we call informative vectors, a classifier for the clinic diagnosis of schizophrenia was established. We experimentally demonstrated that the proposed algorithm incorporating resting-state functional language network achieved 83.6% leaveone- out accuracy on resting-state fMRI data of 27 schizophrenia patients and 28 normal controls. In contrast with KNearest- Neighbor (KNN), Support Vector Machine (SVM) and l1-norm, our method yielded better classification performance. Moreover, our results suggested that a dysfunction of resting-state functional language network plays an important role in the clinic diagnosis of schizophrenia.

  2. Effect of furosemide on pulmonary blood flow distribution in resting and exercising horses

    Science.gov (United States)

    Erickson, H. H.; Bernard, S. L.; Glenny, R. W.; Fedde, M. R.; Polissar, N. L.; Basaraba, R. J.; Walther, S. M.; Gaughan, E. M.; McMurphy, R.; Hlastala, M. P.

    1999-01-01

    We determined the spatial distribution of pulmonary blood flow (PBF) with 15-micron fluorescent-labeled microspheres during rest and exercise in five Thoroughbred horses before and 4 h after furosemide administration (0.5 mg/kg iv). The primary finding of this study was that PBF redistribution occurred from rest to exercise, both with and without furosemide. However, there was less blood flow to the dorsal portion of the lung during exercise postfurosemide compared with prefurosemide. Furosemide did alter the resting perfusion distribution by increasing the flow to the ventral regions of the lung; however, that increase in flow was abated with exercise. Other findings included 1) unchanged gas exchange and cardiac output during rest and exercise after vs. before furosemide, 2) a decrease in pulmonary arterial pressure after furosemide, 3) an increase in the slope of the relationship of PBF vs. vertical height up the lung during exercise, both with and without furosemide, and 4) a decrease in blood flow to the dorsal region of the lung at rest after furosemide. Pulmonary perfusion variability within the lung may be a function of the anatomy of the pulmonary vessels that results in a predominantly fixed spatial pattern of flow distribution.

  3. Contact angles in the pseudopotential lattice Boltzmann modeling of wetting

    CERN Document Server

    Li, Q; Kang, Q J; Chen, Q

    2014-01-01

    In this paper, we aim to investigate the implementation of contact angles in the pseudopotential lattice Boltzmann modeling of wetting at a large density ratio. The pseudopotential lattice Boltzmann model [X. Shan and H. Chen, Phys. Rev. E 49, 2941 (1994)] is a popular mesoscopic model for simulating multiphase flows and interfacial dynamics. In this model, the contact angle is usually realized by a fluid-solid interaction. Two widely used fluid-solid interactions: the density-based interaction and the pseudopotential-based interaction, as well as a modified pseudopotential-based interaction formulated in the present paper, are numerically investigated and compared in terms of the achievable contact angles, the maximum and the minimum densities, and the spurious currents. It is found that the pseudopotential-based interaction works well for simulating small static (liquid) contact angles, however, is unable to reproduce static contact angles close to 180 degrees. Meanwhile, it is found that the proposed modif...

  4. Physical active rest in education of active personality of students

    OpenAIRE

    Zaycev V.P.; Manucharyan S.V.; Kramskoy S.I.

    2010-01-01

    Meaningfulness of physical recreation is rotined in education of active personality of students. Research material is literary sources on this issue. Factors which influence on an educate function of personality of students are considered. Application of physical recreation is grounded for education of active personality of students. It is marked that physical recreation in pedagogical process decides educate, educational, health and social tasks. It positively influences on education of acti...

  5. Determination of rest mass energy of the electron-an undergraduate laboratory experiment

    International Nuclear Information System (INIS)

    We present a simple Compton scattering experiment to determine the rest mass energy of the electron which is unique for graduate and undergraduate laboratories. In the present experiment, we have measured the energies of the backscattered gamma photons with an NaI(Tl) gamma ray spectrometer coupled to a 1 K multichannel analyser. In order to enhance the backscattered gamma photons, a thick aluminium target is placed over the radioactive gamma source. The rest mass energy of the electron is determined by using 203Hg, 137Cs, 54Mn and 60Co radioactive gamma sources. The measured values are found to agree with the standard value

  6. Determination of rest mass energy of the electron-an undergraduate laboratory experiment

    Energy Technology Data Exchange (ETDEWEB)

    Hosur, S B; Badiger, N M [Department of Physics, Karnatak University, Dharwad 580 003, Karnataka (India)

    2007-11-15

    We present a simple Compton scattering experiment to determine the rest mass energy of the electron which is unique for graduate and undergraduate laboratories. In the present experiment, we have measured the energies of the backscattered gamma photons with an NaI(Tl) gamma ray spectrometer coupled to a 1 K multichannel analyser. In order to enhance the backscattered gamma photons, a thick aluminium target is placed over the radioactive gamma source. The rest mass energy of the electron is determined by using {sup 203}Hg, {sup 137}Cs, {sup 54}Mn and {sup 60}Co radioactive gamma sources. The measured values are found to agree with the standard value.

  7. Sensitivity of the resting-state haemodynamic response function estimation to autonomic nervous system fluctuations.

    Science.gov (United States)

    Wu, Guo-Rong; Marinazzo, Daniele

    2016-05-13

    The haemodynamic response function (HRF) is a key component of the blood oxygen level-dependent (BOLD) signal, providing the mapping between neural activity and the signal measured with functional magnetic resonance imaging (fMRI). Most of the time the HRF is associated with task-based fMRI protocols, in which its onset is explicitly included in the design matrix. On the other hand, the HRF also mediates the relationship between spontaneous neural activity and the BOLD signal in resting-state protocols, in which no explicit stimulus is taken into account. It has been shown that resting-state brain dynamics can be characterized by looking at sparse BOLD 'events', which can be retrieved by point process analysis. These events can be then used to retrieve the HRF at rest. Crucially, cardiac activity can also induce changes in the BOLD signal, thus affecting both the number of these events and the estimation of the haemodynamic response. In this study, we compare the resting-state haemodynamic response retrieved by means of a point process analysis, taking the cardiac fluctuations into account. We find that the resting-state HRF estimation is significantly modulated in the brainstem and surrounding cortical areas. From the analysis of two high-quality datasets with different temporal and spatial resolution, and through the investigation of intersubject correlation, we suggest that spontaneous point process response durations are associated with the mean interbeat interval and low-frequency power of heart rate variability in the brainstem. PMID:27044997

  8. [Functional connectivity analysis of the brain network using resting-state FMRI].

    Science.gov (United States)

    Hayashi, Toshihiro

    2011-12-01

    Spatial patterns of spontaneous fluctuations in blood oxygenation level-dependent (BOLD) signals reflect the underlying neural architecture. The study of the brain network based on these self-organized patterns is termed resting-state functional MRI (fMRI). This review article aims at briefly reviewing a basic concept of this technology and discussing its implications for neuropsychological studies. First, the technical aspects of resting-state fMRI, including signal sources, physiological artifacts, image acquisition, and analytical methods such as seed-based correlation analysis and independent component analysis, are explained, followed by a discussion on the major resting-state networks, including the default mode network. In addition, the structure-function correlation studied using diffuse tensor imaging and resting-state fMRI is briefly discussed. Second, I have discussed the reservations and potential pitfalls of 2 major imaging methods: voxel-based lesion-symptom mapping and task fMRI. Problems encountered with voxel-based lesion-symptom mapping can be overcome by using resting-state fMRI and evaluating undamaged brain networks in patients. Regarding task fMRI in patients, I have also emphasized the importance of evaluating the baseline brain activity because the amplitude of activation in BOLD fMRI is hard to interpret as the same baseline cannot be assumed for both patient and normal groups. PMID:22147450

  9. Functional connectivity analysis of the brain network using resting-state fMRI

    International Nuclear Information System (INIS)

    Spatial patterns of spontaneous fluctuations in blood oxygenation level-dependent (BOLD) signals reflect the underlying neural architecture. The study of the brain network based on these self-organized patterns is termed resting-state functional MRI (fMRI). This review article aims at briefly reviewing a basic concept of this technology and discussing its implications for neuropsychological studies. First, the technical aspects of resting-state fMRI, including signal sources, physiological artifacts, image acquisition, and analytical methods such as seed-based correlation analysis and independent component analysis, are explained, followed by a discussion on the major resting-state networks, including the default mode network. In addition, the structure-function correlation studied using diffuse tensor imaging and resting-state fMRI is briefly discussed. Second, I have discussed the reservations and potential pitfalls of 2 major imaging methods: voxel-based lesion-symptom mapping and task fMRI. Problems encountered with voxel-based lesion-symptom mapping can be overcome by using resting-state fMRI and evaluating undamaged brain networks in patients. Regarding task fMRI in patients, I have also emphasized the importance of evaluating the baseline brain activity because the amplitude of activation in BOLD fMRI is hard to interpret as the same baseline cannot be assumed for both patient and normal groups. (author)

  10. The range of options for handling plane angle and solid angle within a system of units

    Science.gov (United States)

    Quincey, Paul

    2016-04-01

    The radian and steradian are unusual units within the SI, originally belonging to their own category of ‘supplementary units’, with this status being changed to dimensionless ‘derived units’ in 1995. Recent papers have suggested that angles could be handled in two different ways within the SI, both differing from the present system. The purpose of this paper is to provide a framework for putting such suggestions into context, outlining the range of options that is available, together with the advantages and disadvantages of these options. Although less rigorously logical than some alternatives, the present SI approach is generally supported, but with some changes to the SI brochure to make the position clearer, in particular with regard to the designation of the radian and steradian as derived units.

  11. Specific silencing of the REST target genes in insulin-secreting cells uncovers their participation in beta cell survival.

    Science.gov (United States)

    Martin, David; Allagnat, Florent; Gesina, Emilie; Caille, Dorothee; Gjinovci, Asllan; Waeber, Gerard; Meda, Paolo; Haefliger, Jacques-Antoine

    2012-01-01

    The absence of the transcriptional repressor RE-1 Silencing Transcription Factor (REST) in insulin-secreting beta cells is a major cue for the specific expression of a large number of genes. These REST target genes were largely ascribed to a function of neurotransmission in a neuronal context, whereas their role in pancreatic beta cells has been poorly explored. To identify their functional significance, we have generated transgenic mice expressing REST in beta cells (RIP-REST mice), and previously discovered that REST target genes are essential to insulin exocytosis. Herein we characterized a novel line of RIP-REST mice featuring diabetes. In diabetic RIP-REST mice, high levels of REST were associated with postnatal beta cell apoptosis, which resulted in gradual beta cell loss and sustained hyperglycemia in adults. Moreover, adenoviral REST transduction in INS-1E cells led to increased cell death under control conditions, and sensitized cells to death induced by cytokines. Screening for REST target genes identified several anti-apoptotic genes bearing the binding motif RE-1 that were downregulated upon REST expression in INS-1E cells, including Gjd2, Mapk8ip1, Irs2, Ptprn, and Cdk5r2. Decreased levels of Cdk5r2 in beta cells of RIP-REST mice further confirmed that it is controlled by REST, in vivo. Using siRNA-mediated knock-down in INS-1E cells, we showed that Cdk5r2 protects beta cells against cytokines and palmitate-induced apoptosis. Together, these data document that a set of REST target genes, including Cdk5r2, is important for beta cell survival. PMID:23029270

  12. Specific silencing of the REST target genes in insulin-secreting cells uncovers their participation in beta cell survival.

    Directory of Open Access Journals (Sweden)

    David Martin

    Full Text Available The absence of the transcriptional repressor RE-1 Silencing Transcription Factor (REST in insulin-secreting beta cells is a major cue for the specific expression of a large number of genes. These REST target genes were largely ascribed to a function of neurotransmission in a neuronal context, whereas their role in pancreatic beta cells has been poorly explored. To identify their functional significance, we have generated transgenic mice expressing REST in beta cells (RIP-REST mice, and previously discovered that REST target genes are essential to insulin exocytosis. Herein we characterized a novel line of RIP-REST mice featuring diabetes. In diabetic RIP-REST mice, high levels of REST were associated with postnatal beta cell apoptosis, which resulted in gradual beta cell loss and sustained hyperglycemia in adults. Moreover, adenoviral REST transduction in INS-1E cells led to increased cell death under control conditions, and sensitized cells to death induced by cytokines. Screening for REST target genes identified several anti-apoptotic genes bearing the binding motif RE-1 that were downregulated upon REST expression in INS-1E cells, including Gjd2, Mapk8ip1, Irs2, Ptprn, and Cdk5r2. Decreased levels of Cdk5r2 in beta cells of RIP-REST mice further confirmed that it is controlled by REST, in vivo. Using siRNA-mediated knock-down in INS-1E cells, we showed that Cdk5r2 protects beta cells against cytokines and palmitate-induced apoptosis. Together, these data document that a set of REST target genes, including Cdk5r2, is important for beta cell survival.

  13. Measurement of the angle of superficial tension by images

    Science.gov (United States)

    Yanez M., Javier; Alonso R., Sergio

    2006-02-01

    When a liquid is deposited on a surface, this one form a certain angle with respect to the surface, where depending on its value, it will conclude that so hard it is his adhesion with the surface. By means of the analysis of images we looked for to measure this angle of superficial tension. In order to make this measurement, we propose a technique by means of projective transformations and one method of regression to estimation parameters to conic fitting.

  14. Sex differences in resting state brain function of cigarette smokers and links to nicotine dependence.

    Science.gov (United States)

    Beltz, Adriene M; Berenbaum, Sheri A; Wilson, Stephen J

    2015-08-01

    Sex--a marker of biological and social individual differences--matters for drug use, particularly for cigarette smoking, which is the leading cause of preventable death in the United States. More men than women smoke, but women are less likely than men to quit. Resting state brain function, or intrinsic brain activity that occurs in the absence of a goal-directed task, is important for understanding cigarette smoking, as it has been shown to differentiate between smokers and nonsmokers. But, it is unclear whether and how sex influences the link between resting state brain function and smoking behavior. In this study, the authors demonstrate that sex is indeed associated with resting state connectivity in cigarette smokers, and that sex moderates the link between resting state connectivity and self-reported nicotine dependence. Using functional MRI and behavioral data from 50 adult daily smokers (23 women), the authors found that women had greater connectivity than men within the default mode network, and that increased connectivity within the reward network was related to increased nicotine tolerance in women but to decreased nicotine tolerance in men. Findings highlight the importance of sex-related individual differences reflected in resting state connectivity for understanding the etiology and treatment of substance use problems. PMID:26237322

  15. Effects of eugenol on resting tension of rat atria

    OpenAIRE

    R.R. Olivoto; C.E.N. Damiani; I. Kassouf Silva; Lofrano-Alves, M.S.; M. A. Oliveira; Fogaça, R.T.H.

    2014-01-01

    In cardiac and skeletal muscle, eugenol (μM range) blocks excitation-contraction coupling. In skeletal muscle, however, larger doses of eugenol (mM range) induce calcium release from the sarcoplasmic reticulum. The effects of eugenol are therefore dependent on its concentration. In this study, we evaluated the effects of eugenol on the contractility of isolated, quiescent atrial trabeculae from male Wistar rats (250-300 g; n=131) and measured atrial ATP content. Eugenol (1, 3, 5, 7, and 10 mM...

  16. Surviving Bed Rest

    Science.gov (United States)

    ... doctor will give you specific information about the duration of your bed rest. continue How Does Bed ... reading about high-risk pregnancy issues, learn about breastfeeding or how to encourage your child's development instead. ...

  17. Transitions into and out of daylight saving time compromise sleep and the rest-activity cycles

    Directory of Open Access Journals (Sweden)

    Lönnqvist Jouko

    2008-02-01

    Full Text Available Abstract Background The aim of this study was to analyze the effects of transition out of and into daylight saving time on the rest-activity cycles and sleep. Rest-activity cycles of nine healthy participants aged 20 to 40 years were measured around transitions out of and into daylight saving time on fall 2005 and spring 2006 respectively. Rest-activity cycles were measured using wrist-worn accelerometers. The participants filled in the Morningness-Eveningness and Seasonal Pattern Assessment Questionnaires before starting the study and kept a sleep diary during the study. Results Fall transition was more disturbing for the more morning type and spring transition for the more evening type of persons. Individuals having a higher global seasonality score suffered more from the transitions. Conclusion Transitions out of and into daylight saving time enhanced night-time restlessness and thereby compromised the quality of sleep.

  18. Calculation of Triggering Angle of Thyristor Rectifiers with Evolutionary Algorithms

    Directory of Open Access Journals (Sweden)

    Fahri VATANSEVER

    2015-05-01

    Full Text Available Rectifier circuits have important role in electrical energy systems. Especially in thyristor rectifiers which have capability of generating multiple voltage level, determining/calculating the optimal trigger angle and applying trigger signal at this angles are among the main process. In this study, desired level of average output voltage according to trigger angles is obtained both classically (mathematically solving of equations and using evolutionary algorithms which are genetic algorithms and differential evolutions. In this way, a software can be used in educational purposes which can calculate optimal trigger angles using both mathematically and heuristically, show results and many properties/parameters of circuit graphically and numerically is developed. Analysis/simulations performed with the designed software indicates that evolutionary algorithms can be used in this field effectively and efficiently.

  19. Effect of antiorthostatic bed rest on hepatic blood flow in man

    Science.gov (United States)

    Putcha, L.; Cintron, N. M.; Vanderploeg, J. M.; Chen, Y.; Habis, J.

    1988-01-01

    Physiological changes that occur during exposure to weightlessness may induce alterations in blood flow to the liver. Estimation of hepatic blood flow (HBF) using ground-based weightlessness simulation models may provide insight into functional changes of the liver in crewmembers during flight. In the present study, HBF, indirectly estimated by indocyanine gree (ICG) clearance, is compared in 10 subjects during the normal ambulatory condition and antiorthostatic (-6 deg) bed rest. Plasma clearance of ICG was determined following intravenous administration of a 0.5-mg/kg dose of ICG to each subject on two separate occasions: once after being seated for 1 h, and once after 24 h of head-down bed rest. After 24 h of head-down bed rest, hepatic blood flow did not change significantly from the respective control value.

  20. VO2 kinetics of constant-load exercise following bed-rest-induced deconditioning

    Science.gov (United States)

    Convertino, V. A.; Goldwater, D. J.; Sandler, H.

    1984-01-01

    Previous studies have shown that the oxygen uptake kinetics during exercise and recovery may be changed by alterations in work intensity, prior exercise, muscle group involvement, ambient conditions, posture, disease state, and level of physical conditioning. However, the effects of detraining on oxygen uptake kinetics have not been determined. The present investigation has the objective to determine the effects of deconditioning following seven days of continuous head-down bed rest on changes in steady-state oxygen uptake, O2 deficit, and recovery oxygen uptake during the performance of constant-load exercise. The obtained results may provide support for previous proposals that submaximal oxygen uptake was significantly reduced following bed rest. The major finding was that bed-rest deconditioning resulted in a reduction of total O2 transport/utilization capacity during the transient phase of upright but not supine exercise.

  1. Research of the Pressure Angle for Whole Cycloidal Gears

    Institute of Scientific and Technical Information of China (English)

    LIU Ling-tao; WANG Jian-hua

    2011-01-01

    The working profile of whole cycloidal gear is made up of epicycloid and hypocycloid entirely, according to the theory of meshing of gears and the properties of the cycloid, deals with the derivation of the pressure angle formula for the whole cycloidal gear in theory, and reveals changes of the pressure angle of whole cycloidal gear through examples, finds the application relationships between the pressure angle and other design parameters of the whole cycloidal gear, proves the possibility that the whole cycloidal gear can be used in internal parallel move gear mechanism, also provides theoretic fundament for designing internal parallel move whole cycloidal gear correctly.

  2. Executive function on the 16-day of bed rest in young healthy men

    Science.gov (United States)

    Ishizaki, Yuko; Fukuoka, Hideoki; Tanaka, Hidetaka; Ishizaki, Tatsuro; Fujii, Yuri; Hattori-Uchida, Yuko; Nakamura, Minako; Ohkawa, Kaoru; Kobayashi, Hodaka; Taniuchi, Shoichiro; Kaneko, Kazunari

    2009-05-01

    Microgravity due to prolonged bed rest may cause changes in cerebral circulation, which is related to brain function. We evaluate the effect of simulated microgravity due to a 6° head-down tilt bed rest experiment on executive function among 12 healthy young men. Four kinds of psychoneurological tests—the table tapping test, the trail making test, the pointing test and losing at rock-paper-scissors—were performed on the baseline and on day 16 of the experiment. There was no significant difference in the results between the baseline and day 16 on all tests, which indicated that executive function was not impaired by the 16-day 6° head-down tilting bed rest. However, we cannot conclude that microgravity did not affect executive function because of the possible contribution of the following factors: (1) the timing of tests, (2) the learning effect, or (3) changes in psychophysiology that were too small to affect higher brain function.

  3. Modeling the flow characteristics during start-up of natural circulation systems from rest state

    International Nuclear Information System (INIS)

    Most of the advanced reactor designs propose to use natural circulation for core heat removal either during normal operational states and/or during off-normal operational states because of simplicity and higher reliability of natural circulation. However, these systems do have their own set of challenges with respect to assessment of their reliability. Simulation of start-up from rest and performance evaluation using conventional models are the key issues in assessing their reliability. In view of their wide importance to nuclear safety, the performance of these systems during start-up from rest is addressed in the present study. (author)

  4. Infinite Relational Modeling of Functional Connectivity in Resting State fMRI

    DEFF Research Database (Denmark)

    Mørup, Morten; Madsen, Kristoffer H.; Dogonowski, Anne Marie;

    2010-01-01

    Functional magnetic resonance imaging (fMRI) can be applied to study the functional connectivity of the neural elements which form complex network at a whole brain level. Most analyses of functional resting state networks (RSN) have been based on the analysis of correlation between the temporal...... dynamics of various regions of the brain. While these models can identify coherently behaving groups in terms of correlation they give little insight into how these groups interact. In this paper we take a different view on the analysis of functional resting state networks. Starting from the definition of...

  5. Measurement of critical contact angle in a microgravity space experiment

    Energy Technology Data Exchange (ETDEWEB)

    Concus, P.; Finn, R.; Weislogel, M.

    1999-06-01

    Mathematical theory predicts that small changes in container shape or in contact angle can give rise to large shifts of liquid in a microgravity environment. This phenomenon was investigated in the Interface Configuration Experiment on board the NASA USML-2 Space Shuttle flight. The experiment's double proboscis containers were designed to strike a balance between conflicting requirements of sizable volume of liquid shift (for ease of observation) and abruptness of the shift (for accurate determination of critical contact angle). The experimental results support the classical concept of macroscopic contact angle and demonstrate the role of hysteresis in impeding orientation toward equilibrium.

  6. Measurement of critical contact angle in a microgravity space experiment

    Energy Technology Data Exchange (ETDEWEB)

    Concus, P. [California Univ., Berkeley, CA (United States). Lawrence Berkeley Lab.; Finn, R. [Department of Mathematics, Stanford University, CA (United States); Weislogel, M. [NASA Lewis Research Center, Cleveland, OH (United States)

    2000-03-01

    Mathematical theory predicts that small changes in container shape or in contact angle can give rise to large shifts of liquid in a microgravity environment. This phenomenon was investigated in the interface configuration experiment on board the NASA USML-2 Space Shuttle flight. The experiment's ''double proboscis'' containers were designed to strike a balance between conflicting requirements of sizable volume of liquid shift (for ease of observation) and abruptness of the shift (for accurate determination of critical contact angle). The experimental results support the classical concept of macroscopic contact angle and demonstrate the role of hysteresis in impeding orientation toward equilibrium. (orig.)

  7. The influence of mosquito resting behaviour and associated microclimate for malaria risk

    Directory of Open Access Journals (Sweden)

    Thomas Matthew B

    2011-07-01

    Full Text Available Abstract Background The majority of the mosquito and parasite life-history traits that combine to determine malaria transmission intensity are temperature sensitive. In most cases, the process-based models used to estimate malaria risk and inform control and prevention strategies utilize measures of mean outdoor temperature. Evidence suggests, however, that certain malaria vectors can spend large parts of their adult life resting indoors. Presentation of hypothesis If significant proportions of mosquitoes are resting indoors and indoor conditions differ markedly from ambient conditions, simple use of outdoor temperatures will not provide reliable estimates of malaria transmission intensity. To date, few studies have quantified the differential effects of indoor vs outdoor temperatures explicitly, reflecting a lack of proper understanding of mosquito resting behaviour and associated microclimate. Testing the hypothesis Published records from 8 village sites in East Africa revealed temperatures to be warmer indoors than outdoors and to generally show less daily variation. Exploring the effects of these temperatures on malaria parasite development rate suggested indoor-resting mosquitoes could transmit malaria between 0.3 and 22.5 days earlier than outdoor-resting mosquitoes. These differences translate to increases in transmission risk ranging from 5 to approaching 3,000%, relative to predictions based on outdoor temperatures. The pattern appears robust for low- and highland areas, with differences increasing with altitude. Implications of the hypothesis Differences in indoor vs outdoor environments lead to large differences in the limits and the intensity of malaria transmission. This finding highlights a need to better understand mosquito resting behaviour and the associated microclimate, and to broaden assessments of transmission ecology and risk to consider the potentially important role of endophily.

  8. Bed rest and immunity

    Science.gov (United States)

    Sonnenfeld, Gerald; Aviles, Hernan; Butel, Janet S.; Shearer, William T.; Niesel, David; Pandya, Utpal; Allen, Christopher; Ochs, Hans D.; Blancher, Antoine; Abbal, Michel

    2007-02-01

    Space flight has been shown to result in altered immune responses. The current study was designed to investigate this possibility by using the bed rest model of some space flight conditions. A large number of women are included as subjects in the study. The hypothesis being tested is: 60 days head-down tilt bed rest of humans will affect the immune system and resistance to infection. Blood, urine and saliva samples will be obtained from bed rest subjects prior to, at intervals during, and after completion of 60 days of head-down tilt bed rest. Leukocyte blastogenesis, cytokine production and virus reactivation will be assessed. The ability of the subjects to respond appropriately to immunization with the neoantigen bacteriophage φX-174 will also be determined. Bed rest is being carried out at MEDES, Toulouse France, and the University of Texas Medical Branch, Galveston, TX. The studies to be carried out in France will also allow assessment of the effects of muscle/bone exercise and nutritional countermeasures on the immune system in addition to the effects of bed rest.

  9. Disrutpted resting-state functional architecture of the brain after 45-day simulated microgravity

    Directory of Open Access Journals (Sweden)

    Yuan eZhou

    2014-06-01

    Full Text Available Long-term spaceflight induces both physiological and psychological changes in astronauts. To understand the neural mechanisms underlying these physiological and psychological changes, it is critical to investigate the effects of microgravity on the functional architecture of the brain. In this study, we used resting-state functional MRI (rs-fMRI to study whether the functional architecture of the brain is altered after 45 days of -6° head-down tilt (HDT bed rest, which is a reliable model for the simulation of microgravity. Sixteen healthy male volunteers underwent rs-fMRI scans before and after 45 days of -6° HDT bed rest. Specifically, we used a commonly employed graph-based measure of network organization, i.e., degree centrality (DC, to perform a full-brain exploration of the regions that were influenced by simulated microgravity. We subsequently examined the functional connectivities of these regions using a seed-based resting-state functional connectivity (RSFC analysis. We found decreased DC in two regions, the left anterior insula (aINS and the anterior part of the middle cingulate cortex (MCC; also called the dorsal anterior cingulate cortex in many studies, in the male volunteers after 45 days of -6° HDT bed rest. Furthermore, seed-based RSFC analyses revealed that a functional network anchored in the aINS and MCC was particularly influenced by simulated microgravity. These results provide evidence that simulated microgravity alters the resting-state functional architecture of the brains of males and suggest that the processing of salience information, which is primarily subserved by the aINS–MCC functional network, is particularly influenced by spaceflight. The current findings provide a new perspective for understanding the relationships between microgravity, cognitive function, autonomic neural function and central neural activity.

  10. Control of Angular Intervals for Angle-Multiplexed Holographic Memory

    Science.gov (United States)

    Kinoshita, Nobuhiro; Muroi, Tetsuhiko; Ishii, Norihiko; Kamijo, Koji; Shimidzu, Naoki

    2009-03-01

    In angle-multiplexed holographic memory, the full width at half maximum of the Bragg selectivity curves is dependent on the angle formed between the medium and incident laser beams. This indicates the possibility of high density and high multiplexing number by varying the angular intervals between adjacent holograms. We propose an angular interval scheduling for closely stacking holograms into medium even when the angle range is limited. We obtained bit error rates of the order of 10-4 under the following conditions: medium thickness of 1 mm, laser beam wavelength of 532 nm, and angular multiplexing number of 300.

  11. Use of resting myocardial scintigraphy during chest pain to exclude diagnosis of acute myocardial infarction

    Energy Technology Data Exchange (ETDEWEB)

    Barbirato, Gustavo Borges; Azevedo, Jader Cunha de; Felix, Renata Christian Martins; Correa, Patricia Lavatori; Volschan, Andre; Viegas, Monica; Pimenta, Lucia; Dohmann, Hans Fernando Rocha; Mesquita, Evandro Tinoco; Mesquita, Claudio Tinoco [Centro de Estudos do Hospital Pro-Cardiaco (Procep), Rio de Janeiro, RJ (Brazil)

    2009-04-15

    Background: Images of myocardial perfusion taken during an episode of chest pain have been used for patients in the emergency department. Objective: To evaluate the operating characteristics of {sup 99m}Tc-Tetrofosmin scintigraphy during an episode of chest pain to exclude the diagnosis of cute myocardial infarction. Methods: One hundred and eight patients admitted with chest pain, or up to four hours after the end of symptoms and non diagnostic electrocardiogram, underwent resting scintigraphy and measurement of troponin I concentrations. Patients with a history of myocardial infarction (MI) were not excluded (24 patients). Troponin I concentrations were determined at admission and 6 hours later. Nuclear physicians performed a blind analysis of the images, and myocardial infarction was confirmed whenever troponin I level increase was three times that of the control. Results: Resting perfusion image was abnormal in all 6 patients with MI. Only 1 patient had a normal image and increased troponin levels. Fifty-five patients had positive images without MI, and 46 patients had normal images and troponin levels. The prevalence of the disease was 6.5%. The sensitivity and specificity of the resting images during an episode of chest pain to diagnose MI was 85.7% and 45.5%, respectively. The negative predictive value was 97.7%. Conclusion: Patients undergoing chest pain protocol with SPECT showed an excellent negative predictive value to exclude diagnosis of myocardial infarction. These results suggest that resting perfusion image is an important tool at the chest pain unit. (author)

  12. Biophysical optimality of the golden angle in phyllotaxis

    Science.gov (United States)

    Okabe, Takuya

    2015-10-01

    Plant leaves are arranged around a stem axis in a regular pattern characterized by common fractions, a phenomenon known as phyllotaxis or phyllotaxy. As plants grow, these fractions often transition according to simple rules related to Fibonacci sequences. This mathematical regularity originates from leaf primordia at the shoot tip (shoot apical meristem), which successively arise at fixed intervals of a divergence angle, typically the golden angle of 137.5°. Algebraic and numerical interpretations have been proposed to explain the golden angle observed in phyllotaxis. However, it remains unknown whether phyllotaxis has adaptive value, even though two centuries have passed since the phenomenon was discovered. Here, I propose a new adaptive mechanism explaining the presence of the golden angle. This angle is the optimal solution to minimize the energy cost of phyllotaxis transition. This model accounts for not only the high precision of the golden angle but also the occurrences of other angles observed in nature. The model also effectively explains the observed diversity of rational and irrational numbers in phyllotaxis.

  13. RESEARCH OF BASIFACIAL CONTOURING SCULPTURE BY MANDIBULAR ANGLE OSTECTOMY

    Institute of Scientific and Technical Information of China (English)

    FANG Jian-lin; DAI Chuan-chang; ZHU Guo-xian; ZHANG Ying; JIN Yu-qing; WANG Wei; QI Chuan-liang

    2006-01-01

    Objective Mandibular angle ostectomy is usually applied to the facial contouring sculpture.We evaluated the various techniques in order to enhance the precision and avoid unnecessary damage. Methods Before operation the area and quantity resected bone were designed according to facial measurement, mandible pantomography and orthophoria and lateral localized radiograph of skull. The Incises of mandibular angle ostectomy included intraoral, retroauricular or intraoral associated with retroauricular. Howerer, the sagittal resection of mandible outer table was necessary in all intraoral incise. Results Single mandibular angle ostectomy was not satisfactory for the patients having mandible hypertrophy with over-width basifacial contouring. Mandibular angle ostectomy combined with the sagittal resection of outer table of mandibular angle were required. Good symmetry and ap pearance were gained in 206 cases. One case had facial paralysis. Two patients occured mandibular fracture during the operation. Three cases complicated angled deformity at mandible body. Conclusion Reduction mandibuloplasty should be selected depends on varied types of mandibular angle hypertrophy before operation.

  14. The Metabolic Cost of a High Intensity Exercise Program During Bed Rest

    Science.gov (United States)

    Hackney, Kyle; Everett, Meghan; Guined, Jamie; Cunningham, Daid

    2012-01-01

    Background: Given that disuse-related skeletal muscle atrophy may be exacerbated by an imbalance between energy intake and output, the amount of energy required to complete exercise countermeasures is an important consideration in the well being of subject health during bed rest and spaceflight. Objective: To evaluate the energy cost of a high intensity exercise program performed during short duration bed rest. Methods: 9 subjects (8 male and 1 female; 34.5 +/- 8.2 years) underwent 14 days of bed rest and exercise countermeasures. Exercise energy expenditure and excess post exercise oxygen consumption (EPOC) were collected once in each of 5 different exercise protocols (30 second, 2 minute and 4 minute intervals, continuous aerobic and a variety of resistance exercises) during bed rest. Body mass, basal metabolic rate (BMR), upper and lower leg muscle, subcutaneous, and intramuscular adipose tissue (IMAT) volumes were assessed before and at the end of bed rest. Results: There were no significant differences in body mass (pre: 75.1 +/- 10.5 kg; post: 75.2 +/- 10.1 kg), BMR (pre: 1649 +/- 216 kcal; post: 1657 +/- 177 kcal), muscle subcutaneous, or IMAT volumes (Table 2) after 14 days of bed rest and exercise. Body mass was maintained with an average daily intake of 2710 +/- 262 kcal (36.2 +/- 2.1 kcal/kg/day), while average daily energy expenditure was 2579 +/-311 kcal (34.5 +/- 3.6 kcal/kg/day). Exercise energy expenditure was significantly greater as a result of continuous aerobic exercise than all other exercise protocols.

  15. Isolation by sugar flotation has no direct effect on the hatching success of zooplankton resting eggs

    Directory of Open Access Journals (Sweden)

    Dunja Lukic

    2016-03-01

    Full Text Available Zooplankton in temporary waters produces resting stages to survive recurrent dry periods. Branchiopod crustaceans (i.e., cladocerans, large branchiopods overcome these periods in the form of resting eggs buried in the sediment. Examining the diversity in the resting egg banks allows for a more accurate estimation of biodiversity of aquatic ecosystems than looking only at the active communities. The isolation of resting eggs from the sediment may be achieved by the sugar flotation method, which usually results in higher density and diversity than untreated samples (i.e., incubated in the sediment. We tested the effect of sugar isolation and centrifugation on the hatching success of resting eggs already isolated from sediment in order to reveal any direct effects on hatching success. We used four different branchiopod species, Daphnia magna, Moina brachiata, Branchinecta orientalis, and Triops cancriformis. Although we hypothesised that osmotic stress caused by sugar and centrifuging influence the hatching success either positively (e.g., faster activation as a response to osmotic changes or negatively (destroyed by centrifugation, we found no significant difference either in the timing or rate of hatching between centrifuged and non-centrifuged eggs. Once the eggs are exposed to light and/or oxygen availability by being removed from the sediment, the centrifugation process does not have any additional effect on their hatching. Regardless of treatment, we found a significant difference in the hatching timing in the two major groups, with large branchiopods hatching earlier than cladocerans. We found that the sugar flotation method itself does not influence the hatching fraction of branchiopod resting eggs (implying no adverse effect on their viability and its success in enhancing hatching can be attributed to its efficiency in removing eggs from the sediment.

  16. Viewing angle switching of patterned vertical alignment liquid crystal display

    International Nuclear Information System (INIS)

    Viewing angle control of a patterned vertical alignment (PVA) liquid crystal display using only one panel is investigated. In conventional PVA modes, a vertically aligned liquid crystal (LC) director tilts down in four directions making 45 deg. with respect to crossed polarizers to exhibit a wide viewing angle. In the viewing angle control device, one pixel was divided into two sub-pixels such that the LC director in the main pixel is controlled to be tilted down in multiple directions making an angle with the polarizer, playing the role of main display with the wide viewing angle, while the LC director in the sub-pixel is controlled to be tilted down to the polarizer axis, playing the role of sub-pixel to the viewing angle control for the narrow viewing angle. Using sub-pixel control, light leakage or any type of information such as characters and image can be generated in oblique viewing directions without distorting the image quality in the normal direction, which will prevent others from peeping at the displayed image by overlapping the displayed image with the made image

  17. Consequences of manganese intoxication on the circadian rest-activity rhythms in the rat.

    Science.gov (United States)

    Bouabid, Safa; Fifel, Karim; Benazzouz, Abdelhamid; Lakhdar-Ghazal, Nouria

    2016-09-01

    Manganese (Mn) intoxication is associated with neurological dysfunctions collectively known as Parkinsonism or Manganism. Like in Parkinson's disease, Manganism is associated with motor disturbances, together with non-motor symptoms including cognitive and neuropsychiatric deficits. Although sleep dysfunctions are commonly reported among workers exposed to Mn, their underlying pathophysiology remains unknown. In this study, we investigated the rest-activity rhythms in rats treated daily with MnCl2 (10mg/kg, i.p) for 5weeks. Locomotor activity was assessed under a light-dark (LD) cycle, constant darkness (DD) and during adjustment to 6h shifts of the LD cycle. In LD conditions, Mn-treated rats exhibited a more fragmented and less stable rest-activity rhythm in addition to a reduction in the total 24-h amount of locomotor activity as well as in the activity confined to the active dark phase of the LD. Consequently, a significant decrease in the amplitude of the rest-activity rhythm was observed. These disturbances were displayed during and after Mn treatment. Furthermore, after the 6-h phase advance of the LD cycle, Mn-treated rats failed to re-adjust accurately their behavioral activity to the new shifted LD cycle. Upon release from LD into DD, Mn-treated rats expressed a normal and stable free-running period of their rest-activity rhythm (23.92±0.07h in Mn group vs. 24.01±0.04h in control rats). However, their rest-activity rhythm remained highly fragmented and less stable. Our results provide the first evidence that chronic Mn intoxication leads to impairment of rest-activity rhythms in addition to the motor and non-motor disturbances reported in Manganism. PMID:27316552

  18. Production of vanillic acid from vanillin by resting cells of Serratia marcescens.

    OpenAIRE

    Perestelo, F.; Dalcón, M A; G. De La Fuente

    1989-01-01

    Resting-cell suspensions of Serratia marcescens were able to convert, quantitatively, 0.3% vanillin to vanillic acid. The vanillic acid-producing activity reached a maximum after 28 h of incubation with 0.01% vanillin as an inducer.

  19. The metabolic and hemodynamic effects of prolonged bed rest in normal subjects

    Science.gov (United States)

    Chobanian, A. V.; Lille, R. D.; Tercyak, A.; Blevins, P.

    1974-01-01

    Investigation in six normal subjects of the effects of chronic bed rest on the interrelationships between cardiovascular hemodynamics, catecholamine metabolism, vascular reactivity, renin and aldosterone activity, and electrolyte and fluid balance. Negative sodium and potassium balances and reductions in plasma volume were observed in all subjects, but plasma renin activity and aldosterone secretory rate showed no significant change. Other findings included the observation that major decreases in sodium balance and plasma volume occurred in the early bed rest period and did not correlate closely with the degree of orthostatic intolerance.

  20. Increasing efficacy of graminicides with a forward angled spray

    DEFF Research Database (Denmark)

    Jensen, Peter Kryger

    2012-01-01

    Control of annual grass species with vertically oriented leaves in agricultural crops by application of foliar acting herbicides with conventional hydraulic sprayers can be increased using forward angled nozzles. Changing the spray angle from the normally predominantly vertical spray towards...... efficacy on L. perenne at early growth stages using nozzles with different spray quality, at different driving speeds and in different wind conditions. Similarly graminicide efficacy was increased when nozzles were angled 60° forward controlling A. myosuroides. Experiments investigating control of the two...

  1. Mixing angle of doubly heavy baryons in QCD

    International Nuclear Information System (INIS)

    We calculate the mixing angles between the spin-1/2, Ξbc-Ξbc′ and Ωbc-Ωbc′ states of doubly heavy baryons within the QCD sum rules method. It is found that the mixing angles are large and have the values φΞbc=16°±5° and φΩbc=18°±6°, respectively. The mixing angles are slightly smaller compared to the predictions of the non-relativistic quark model, φΞbc=25.5° and φΩbc=25.9°.

  2. Unexpected increases in rotifer resting egg abundances during the period of contamination of Lake Orta

    Directory of Open Access Journals (Sweden)

    Roberta Piscia

    2016-04-01

    Full Text Available Despite their ecological importance and rapid response to environmental changes, rotifers are rarely included in palaeolimnological studies. Here, we describe changes in abundance (ABD and morphotype (MTs diversity of rotifer resting eggs in the sediments of deep subalpine Lake Orta, Italy, covering a period prior to (pre- 1926, during long-term ammonia and metal pollution from a rayon factory, and subsequent recovery of water quality. Following the pollution and bacterial oxidation of the ammonia, Lake Orta became the largest and deepest acid lake in Europe. Recovery of water quality followed both a ban on the discharge of industrial wastes, and a liming intervention in 1989 and 1990. We sectioned a sediment core collected from the deepest part of the lake (ORTA 07/2A to provide a high  time resolution, given the ca. 3-4 y cm-1 of sediment accumulation. Rotifer resting egg (RRE abundance and morphotypes were examined from the sediments and compared to limnological variables indicating the pollution. Rotifer resting egg abundance significantly increased with lake contamination (r=0.609 and -0.624 for copper and pH, respectively; P<0.001; n=27. A lake-water copper concentration threshold of ca. 40 µg L-1discriminated among pre-, during-, and post- pollution compositions of the rotifer morphotype assemblages. Diversity and morphotype richness increased during the recovery from copper pollution and with complete restoration from acidity, while abundance increased during pollution. The persistence of presumably viable Brachionus resting eggs and of hatched egg cases during the heavy pollution phase suggests that, unlike most other organisms, which were extirpated by the pollution of the lake, rotifers survived producing resting eggs, which secured future generations.

  3. Shrinkage and trajectory of the flat jet with inclination angle

    Institute of Scientific and Technical Information of China (English)

    Shufeng Ye; Yusheng Xie; Hongzhi Guo; Ye Huang; Shantong Jin

    2003-01-01

    The performance of the flat jet with an inclination angle was investigated by a water model. A mathematical model for theshrinkage and the trajectory of the flat jet with an inclination angle was derived theoretically and verified by experimental data of thewater model. The experimental results indicate that the inclination angle (α) has no influence on the shrinkage of the flat jet, theshrinkage of the flat jet along the width direction decreases with the increasing of the initial velocity at the exit (u0) and the initialthickness of the flat jet (t0). Enough bigger initial exit velocity (u0) and initial thickness can suppress the shrinkage of the flat jetalong the width direction and keep the flat jet stabilized. In addition, the trajectory of the flat jet with an inclination angle is parabolicand must be taking into consideration when to determine the striking distance.

  4. Propagation of photons in resting and moving media

    CERN Document Server

    Zalesny, J

    2001-01-01

    The propagation of photon in a dielectric may be described with the help of the scalar and vector potentials of the medium. The main novelty of the paper is that the concept of the vector potential (which is connected with the velocity of the medium) can be extended to relativistic velocities of the medium. The position-dependent photon wave function was used to describe the propagation of the photon. The new concepts of the velocity of photon as particle and the photon mass in the dielectric medium were proposed.

  5. The Use of Horizontal and Vertical Angles in Terrestrial Navigation

    OpenAIRE

    Lušić, Zvonimir

    2013-01-01

    The methods of determining a ship’s position in terrestrial navigation by using vertical and horizontal angles are nowadays rarely used. The reason is the relative complexity of the procedure and the lack of accuracy of some methods. Different methods of using horizontal and vertical angles to obtain the line of position (LOP) will be presented in this paper, as well as the occurring errors and recommendations for use. In this paper, the sextant will be considered a basic...

  6. On Ruby's solid angle formula and some of its generalizations

    CERN Document Server

    Friot, Samuel

    2014-01-01

    Using the Mellin-Barnes representation, we show that Ruby's solid angle formula and some of its generalizations may be expressed in a compact way in terms of the Appell F4 and Lauricella Fc functions.

  7. On Ruby's solid angle formula and some of its generalizations

    Science.gov (United States)

    Friot, Samuel

    2015-02-01

    Using the Mellin-Barnes representation, we show that Ruby's solid angle formula and some of its generalizations may be expressed in a compact way in terms of the Appell F4 and Lauricella FC functions.

  8. Setting of angles on machine tools speeded by magnetic protractor

    Science.gov (United States)

    Vale, L. B.

    1964-01-01

    An adjustable protractor facilitates transference of angles to remote machine tools. It has a magnetic base incorporating a beam which can be adjusted until its shadow coincides with an image on the screen of a projector.

  9. Structural analysis of osseous rests exposed to heating

    International Nuclear Information System (INIS)

    Heat exposed human remains present physical and chemical changes that, when analysed, may provide important indications about the type of heating they were exposed. This information, jointly with that of the archaeological context, allows us to know about the cultural practices of the past from a methodological perspective that actually, has not been explored sufficiently. The present investigation applies a series of structural parameters of bone in the evaluation of skeletal sample from the archaeological site of Calakmul, which exhibits signs of thermal exposure. Results on the Pre hispanic specimens are compared to those obtained from an experimental series of animal bone, which was submitted to different types of heat with the objective to contribute with new data on the forms of heating and their role in ancient Maya society. (Author)

  10. The Rest of the Story: Finding Meaning in Stylistic Variation

    Science.gov (United States)

    Argamon, Shlomo; Koppel, Moshe

    The computational analysis of the style of natural language texts, computational stylistics, seeks to develop automated methods to (1) effectively distinguish texts with one stylistic character from those of another, and (2) give a meaningful representation of the differences between textual styles. Such methods have many potential applications in areas including criminal and national security forensics, customer relations management, spam/scam filtering, and scholarly research. In this chapter, we propose a framework for research in computational stylistics, based on a functional model of the communicative act. We illustrate the utility of this framework via several case studies.

  11. Intensive reasoning training alters patterns of brain connectivity at rest

    OpenAIRE

    Mackey, AP; Singley, ATM; Bunge, SA

    2013-01-01

    Patterns of correlated activity among brain regions reflect functionally relevant networks that are widely assumed to be stable over time. We hypothesized that if these correlations reflect the prior history of coactivation of brain regions, then a marked shift in cognition could alter the strength of coupling between these regions. We sought to test whether intensive reasoning training in humans would result in tighter coupling among regions in the lateral frontoparietal network, as measured...

  12. Evaluation of Distributed SOAP and RESTful MobileWeb Services

    OpenAIRE

    AlShahwan, F; Moessner, K.; Carrez, F

    2010-01-01

    Even mobile Web Services are still provided using servers that usually reside in the core networks. Main reason for not providing large and complex Web Services from resource limited mobile devices is not only the volatility of wireless connections and mobility of mobile hosts, but also, the often limited processing power. Offloading of some of the processing tasks is one step towards achieving optimal mobile Web Service provision. This paper presents two frameworks for providing distributed ...

  13. Winning Facebook - and the Rest of the World?

    DEFF Research Database (Denmark)

    Hoff, Jens Villiam; Hansen, Kasper Møller; Schwartz, Sander Andreas;

    2014-01-01

    This article presents a study of nine leading candidates’ communication on Facebook during the parliament election campaign in Denmark in fall 2011. It relates their communication to the historical use of social media in Denmark by politicians, to Danish candidate campaign communication in general...... conclude that certain types of content may win Facebook, but the election itself is still largely won through TV....

  14. The Rest of the Elephant: Perspectives on the Mass Media.

    Science.gov (United States)

    Stevens, John D.; Porter, William E.

    This book presents an analytical introduction to the study of the mass media. Aspects of media that have received little attention--audiences, economics, working processes and ethics--are treated in the four sections of the book. Section one covers symbiosis between the medium and the audience. Section two discusses the way in which business and…

  15. The Rest-Frame Extreme Ultraviolet Spectral Properties of QSOs

    OpenAIRE

    Telfer, R. C.; Zheng, W.; Kriss, G. A.; Davidsen, A. F.

    2001-01-01

    We use a sample of 332 Hubble Space Telescope spectra of 184 QSOs with z > 0.33 to study the typical ultraviolet spectral properties of QSOs, with emphasis on the ionizing continuum. Our sample is nearly twice as large as that of Zheng et al. (1997) and provides much better spectral coverage in the extreme ultraviolet (EUV). The overall composite continuum can be described by a power law with index alpha_EUV = -1.76 +/- 0.12 (f_nu ~ nu^alpha) between 500 and 1200 Angstroms. The corresponding ...

  16. First statistics of the isopistonic angle for long baseline interferometry

    Science.gov (United States)

    Ziad, A.; Elhalkouj, T.; Petrov, R. G.; Borgnino, J.; Lazrek, M.; Benkhaldoun, Z.; Martin, F.; Elazhari, Y.

    2016-06-01

    To reach a suitable limiting magnitude with a multi-aperture interferometer, we need to cophase the different telescopes using a reference source. The latter should be located in the same isopistonic domain as the science source. We developed a direct analytical expression of deducing the isopistonic angle from atmospheric optical parameters as seeing, isoplanatic angle and outer scale. All of these atmospheric turbulence parameters are measured by the Generalized Seeing Monitor (GSM). The first statistics of the isopistonic angle obtained from the GSM data are presented and comparison between the major sites over the world are discussed (La Silla, Cerro Pachon, Paranal, San Pedro, Mt Palomar, Mauna Kea, La Palma, Oukaïmeden, Maydanak, Dome C). Implications of these isopistonic angle statistics on large interferometers cophasing in terms of sky coverage and limiting magnitude are discussed.

  17. On humanoids, avatars and the rest of us

    DEFF Research Database (Denmark)

    Søndergaard, Dorte Marie

    swex/gender in the enactment of that imitation. Examples involve avatars from computer games, robots, mainly androids and geminoids and perhaps most importantly the Spaces between imaginaries and their materializations within this broad field of Technologies. Late in the paper, I will include figures...

  18. Accurate rest frequencies of methanol maser and dark cloud lines

    CERN Document Server

    Müller, H S P; Maeder, H

    2004-01-01

    We report accurate laboratory measurements of selected methanol transition frequencies between 0.834 and 230 GHz in order to facilitate astronomical velocity analyses. New data have been obtained between 10 and 27 GHz and between 60 and 119 GHz. Emphasis has been put on known or potential interstellar maser lines as well as on transitions suitable for the investigation of cold dark clouds. Because of the narrow line widths (<0.5 kms-1) of maser lines and lines detected in dark molecular clouds, accurate frequencies are needed for comparison of the velocities of different methanol lines with each other as well as with lines from other species. In particular, frequencies for a comprehensive set of transitions are given which, because of their low level energies (< 20 cm-1 or 30 K) are potentially detectable in cold clouds. Global Hamiltonian fits generally do not yet yield the required accuracy. Additionally, we report transition frequencies for other lines that may be used to test and to improve existing...

  19. Massless particles plus matter in the rest-frame instant form of dynamics

    International Nuclear Information System (INIS)

    After introducing the parametrized Minkowski theory describing a positive-energy scalar massless particle, we study the rest-frame instant form of dynamics of such a particle in the presence of another massive one (to avoid the front form of dynamics). Then we describe massless particles with Grassmann-valued helicity and their quantization.

  20. Affective mentalizing and brain activity at rest in the behavioral variant of frontotemporal dementia

    Directory of Open Access Journals (Sweden)

    Silvia P. Caminiti

    2015-01-01

    Conclusions: Some of the observed effects may reflect specific compensatory mechanisms for the atrophic changes involving regions in charge of affective mentalizing. The analysis of specific resting-state networks thus highlights an intermediate level of analysis between abnormal brain structure and impaired behavioral performance in bvFTD, reflecting both dysfunction and compensation mechanisms.

  1. Determination of refractive index of various materials on Brewster angle

    CERN Document Server

    Tikhonov, Eugene A

    2015-01-01

    Studied experimentally the origin of the non-zero reflection of p-polarized radiation (TM) of Brewster's angle. The results have shown the residual reflected light in the vicinity of Brewster angle occurs due to inaccessibility 100% polarization degree the incident linearly-polarized radiation and installation of the zero azimuthal angle. These factors create the s-component of the radiation reflected from the examined surface indeed. A smooth change of reflected light polarization in the vicinity of Brewster angle in the sequence p-s-p appears due to the changing power proportion of reflected p-, and s-components but not is the result of the atomically thin transitional layer at the border of the material/environment according to Drude model. Metrological aspects of refractive index measurement by Brewster angle are investigated: due to the above-mentioned factors, as well as due to the contribution of the reflected scattered light caused by on residual roughness of the optical surface. Advantages of Brewste...

  2. Restful Implementation of Catalogue Service for Geospatial Data Provenance

    OpenAIRE

    Jiang, L. C.; Yue, P.; Lu, X. C.

    2013-01-01

    Provenance, also known as lineage, is important in understanding the derivation history of data products. Geospatial data provenance helps data consumers to evaluate the quality and reliability of geospatial data. In a service-oriented environment, where data are often consumed or produced by distributed services, provenance could be managed by following the same service-oriented paradigm. The Open Geospatial Consortium (OGC) Catalogue Service for the Web (CSW) is used for the regist...

  3. CONDITIONS OF DRIVER"S WORK AND REST

    OpenAIRE

    N Galkina

    2005-01-01

    Driver"s efficiency, his ability to perform physical and mental work connected with driving skillfully maintain specified speed and overcome fatigue are naturally changing during the working day. To research driver"s efficient work under various road conditions, it is necessary to predict the change of driver"s efficiency phases under different ratios and absolute values of physical activity and data traffic.

  4. Parameterization of ion channeling half-angles and minimum yields

    Science.gov (United States)

    Doyle, Barney L.

    2016-03-01

    A MS Excel program has been written that calculates ion channeling half-angles and minimum yields in cubic bcc, fcc and diamond lattice crystals. All of the tables and graphs in the three Ion Beam Analysis Handbooks that previously had to be manually looked up and read from were programed into Excel in handy lookup tables, or parameterized, for the case of the graphs, using rather simple exponential functions with different power functions of the arguments. The program then offers an extremely convenient way to calculate axial and planar half-angles, minimum yields, effects on half-angles and minimum yields of amorphous overlayers. The program can calculate these half-angles and minimum yields for axes and [h k l] planes up to (5 5 5). The program is open source and available at

  5. Comparison of different passive knee extension torque-angle assessments

    International Nuclear Information System (INIS)

    Previous studies have used isokinetic dynamometry to assess joint torques and angles during passive extension of the knee, often without reporting upon methodological errors and reliability outcomes. In addition, the reliability of the techniques used to measure passive knee extension torque-angle and the extent to which reliability may be affected by the position of the subjects is also unclear. Therefore, we conducted an analysis of the intra- and inter-session reliability of two methods of assessing passive knee extension: (A) a 2D kinematic analysis coupled to a custom-made device that enabled the direct measurement of resistance to stretch and (B) an isokinetic dynamometer used in two testing positions (with the non-tested thigh either flexed at 45° or in the neutral position). The intra-class correlation coefficients (ICCs) of torque, the slope of the torque-angle curve, and the parameters of the mathematical model that were fit to the torque-angle data for the above conditions were measured in sixteen healthy male subjects (age: 21.4 ± 2.1 yr; BMI: 22.6 ± 3.3 kg m−2; tibial length: 37.4 ± 3.4 cm). The results found were: (1) methods A and B led to distinctly different torque-angle responses; (2) passive torque-angle relationship and stretch tolerance were influenced by the position of the non-tested thigh; and (3) ICCs obtained for torque were higher than for the slope and for the mathematical parameters that were fit to the torque-angle curve. In conclusion, the measurement method that is used and the positioning of subjects can influence the passive knee extension torque-angle outcome. (paper)

  6. Multimodal analysis of cortical chemoarchitecture and macroscale fMRI resting-state functional connectivity.

    Science.gov (United States)

    van den Heuvel, Martijn P; Scholtens, Lianne H; Turk, Elise; Mantini, Dante; Vanduffel, Wim; Feldman Barrett, Lisa

    2016-09-01

    The cerebral cortex is well known to display a large variation in excitatory and inhibitory chemoarchitecture, but the effect of this variation on global scale functional neural communication and synchronization patterns remains less well understood. Here, we provide evidence of the chemoarchitecture of cortical regions to be associated with large-scale region-to-region resting-state functional connectivity. We assessed the excitatory versus inhibitory chemoarchitecture of cortical areas as an ExIn ratio between receptor density mappings of excitatory (AMPA, M1 ) and inhibitory (GABAA , M2 ) receptors, computed on the basis of data collated from pioneering studies of autoradiography mappings as present in literature of the human (2 datasets) and macaque (1 dataset) cortex. Cortical variation in ExIn ratio significantly correlated with total level of functional connectivity as derived from resting-state functional connectivity recordings of cortical areas across all three datasets (human I: P = 0.0004; human II: P = 0.0008; macaque: P = 0.0007), suggesting cortical areas with an overall more excitatory character to show higher levels of intrinsic functional connectivity during resting-state. Our findings are indicative of the microscale chemoarchitecture of cortical regions to be related to resting-state fMRI connectivity patterns at the global system's level of connectome organization. Hum Brain Mapp 37:3103-3113, 2016. © 2016 Wiley Periodicals, Inc. PMID:27207489

  7. Change Creation: The Rest of the Planning Story.

    Science.gov (United States)

    Lick, Dale W.; Kaufman, Roger

    2001-01-01

    Introduces a new, comprehensive planning and change concept for universities, "change creation," that encompasses both strategic planning and a transition process for the organization from "what is" to "what should be." After exploring change, why it often fails, and the tenets of change creation, presents its steps. A few are: leadership team…

  8. Increased power of resting-state gamma oscillations in autism spectrum disorder detected by routine electroencephalography

    NARCIS (Netherlands)

    van Diessen, Eric; Senders, Joeky; Jansen, Floor E.; Boersma, Maria; Bruining, Hilgo

    2015-01-01

    Experimental studies suggest that increased resting-state power of gamma oscillations is associated with autism spectrum disorder (ASD). To extend the clinical applicability of this finding, we retrospectively investigated routine electroencephalography (EEG) recordings of 19 patients with ASD and 1

  9. Organization of the safe working conditions and rest of citizens on the factors of noise pollution

    OpenAIRE

    Sankov, P.

    2016-01-01

    Goal. Scientific studies and analysis capabilities of enhance life safety in residential and industrial areas of modern cities using mobile systems gardening. Methods. Using a systematic approach in analytical studies, literature, modern urban planning development  specialists ecology  and life for the purpose of safe working conditions and rest of citizens on noise pollution factor using landscaping reconstruction of modern cities. Results. In this work, the technique of safe working conditi...

  10. Reduction of blade passage tone by angle modulation

    Science.gov (United States)

    Fiagbedzi, Y. A.

    1982-05-01

    Blade staggering has been used in both centrifugal and axial flow fans to reduce discrete tones. Impeller hub resilience, causing fan torsional oscillations, appears to be equivalent to blade staggering in that both lead to angle modulation of the blade passage sound. By using Jacobi-Anger expansions, the sound reductions resulting from the angle modulation effects of these two equivalent techniques are predicted. Excellent agreement is found with published data.

  11. Measurement of Strabismic Angle Using the Distance Krimsky Test

    OpenAIRE

    Joo, Kwang Sic; Koo, Hyun; Moon, Nam Ju

    2013-01-01

    Purpose To evaluate the correlation of the distance Krimsky test and the alternate prism cover test (APCT) for the distance deviation in patients with horizontal strabismus. Methods Forty patients with horizontal strabismus (20 esotropia and 20 exotropia) were included in this study. Patients with a variable angle of deviation, vertical angle over 5 prism diopters, impaired binocular vision, or poor cooperation were excluded. We instructed the patient to look a target 6 meters away, and appli...

  12. Neoclassical Pitch-Angle Scattering of Runaway Electrons

    CERN Document Server

    Liu, Jian; Qin, Hong

    2015-01-01

    It is discovered that the tokamak field geometry generates a pitch-angle scattering effect for runaway electrons. This neoclassical pitch-angle scattering is much stronger than the collisional scattering and invalidates the gyro-center model for runaway electrons. As a result, the energy limit of runaway electrons is found to be larger than the prediction of the gyro-center model and to depend heavily on the background magnetic field.

  13. Advanced conduction angle control of permanent magnet brushless motor drives

    OpenAIRE

    Gan, J.; Chan, CC; Jiang, JZ; Chau, KT

    1998-01-01

    A novel advanced conduction angle control scheme for permanent magnet brushless motor drives is presented in this paper. The originality of this scheme is to employ the transformer EMF in stator windings to counteract the rotational EMF by controlling the advanced conduction angle when the motor drive operates above the base speed. Hence the constant-power operation region can be extended considerably, even though the current regulator is in saturation. The attractive feature of the proposed ...

  14. Ethnic differences in thermoregulatory responses during resting, passive and active heating: application of Werner's adaptation model.

    Science.gov (United States)

    Lee, Joo-Young; Wakabayashi, Hitoshi; Wijayanto, Titis; Hashiguchi, Nobuko; Saat, Mohamed; Tochihara, Yutaka

    2011-12-01

    For the coherent understanding of heat acclimatization in tropical natives, we compared ethnic differences between tropical and temperate natives during resting, passive and active heating conditions. Experimental protocols included: (1) a resting condition (an air temperature of 28°C with 50% RH), (2) a passive heating condition (28°C with 50% RH; leg immersion in a hot tub at a water temperature of 42°C), and (3) an active heating condition (32°C with 70% RH; a bicycle exercise). Morphologically and physically matched tropical natives (ten Malaysian males, MY) and temperate natives (ten Japanese males, JP) participated in all three trials. The results saw that: tropical natives had a higher resting rectal temperature and lower hand and foot temperatures at rest, smaller rise of rectal temperature and greater temperature rise in bodily extremities, and a lower sensation of thirst during passive and active heating than the matched temperate natives. It is suggested that tropical natives' homeostasis during heating is effectively controlled with the improved stability in internal body temperature and the increased capability of vascular circulation in extremities, with a lower thirst sensation. The enhanced stability of internal body temperature and the extended thermoregulatory capability of vascular circulation in the extremities of tropical natives can be interpreted as an interactive change to accomplish a thermal dynamic equilibrium in hot environments. These heat adaptive traits were explained by Wilder's law of initial value and Werner's process and controller adaptation model. PMID:21437607

  15. Computerized two-lead resting ECG analysis for the detection of coronary artery stenosis after coronary revascularization

    OpenAIRE

    Grube, Eberhard; Bootsveld, Andreas; Buellesfeld, Lutz; Yuecel, Seyrani; Shen, Joseph T; Imhoff, Michael

    2008-01-01

    Background: Resting electrocardiogram (ECG) shows limited sensitivity and specificity for the detection of coronary artery disease (CAD), where patients with a history of coronary revascularization may pose special challenges. Several methods exist to enhance sensitivity and specificity of resting ECG for diagnosis of CAD, but such methods are not better than a specialist's judgement. We compared a new computer-enhanced, resting ECG analysis device, 3DMP, to coronary angiography to evaluate t...

  16. Static and Dynamic Contact Angles of Immersed Ferrofluid Droplets

    Science.gov (United States)

    Chatterjee, Souvick; Bhowmik, Dipanwita; Mukhopadhyay, Achintya; Ganguly, Ranjan

    2013-11-01

    Ferrofluid plug driven micro-pumps are useful for manipulating micro-volume of liquids by providing remote actuation using a localized magnetic field gradient. Inside a microchannel, the ferrofluid experiences combined actions of different relevant body forces. While the pressure, viscous and magnetic forces can be estimated using established techniques, the surface tension force requires information about the contact angle between the ferrofluid and glass capillary wall. We address this phenomenon through experimental characterization of static and dynamic contact angles of oil based ferrofluid (EFH3) droplets on glass surface immersed in pure or surfacted distilled water. The equilibrium static contact angle is found to significantly reduce in presence of a magnetic field. Dynamic contact angles are measured through high-speed imaging as the ferrofluid droplets slide along an inclined glass surface. Variation of contact angle hysteresis, which falls outside the Hoffmann Tanner equation for this case, is also investigated as a function of contact line velocity. A strong dependence is found between the contact angle hysteresis and the wetting time. Findings of the work is useful for designing ferrofluid plug-driven microfluidic plugs for different lab-on-a-chip applications.

  17. Jet opening angles and gamma-ray brightness of AGN

    CERN Document Server

    Pushkarev, A B; Lister, M L; Savolainen, T

    2009-01-01

    We have investigated the differences in apparent opening angles between the parsec-scale jets of the active galactic nuclei (AGN) detected by the Fermi Large Area Telescope (LAT) during its first three months of operations and those of non-LAT-detected AGN. We used 15.4 GHz VLBA observations of sources from the 2 cm VLBA MOJAVE program, a subset of which comprise the statistically complete flux density limited MOJAVE sample. We determined the apparent opening angles by analyzing transverse jet profiles from the data in the image plane and by applying a model fitting technique to the data in the (u,v) plane. Both methods provided comparable opening angle estimates. The apparent opening angles of gamma-ray bright blazars are preferentially larger than those of gamma-ray weak sources. At the same time, we have found the two groups to have similar intrinsic opening angle distributions. This suggests that the jets in gamma-ray bright AGN are oriented at preferentially smaller angles to the line of sight resulting ...

  18. Investigating the impact of optical selection effects on observed rest frame prompt GRB properties

    CERN Document Server

    Turpin, Damien; Dezalay, Jean-Pascal; Atteia, Jean-Luc; Klotz, Alain; Dornic, Damien

    2016-01-01

    Measuring gamma-ray burst (GRB) properties in their rest-frame is crucial to understand the physics at work in gamma-ray bursts. This can only be done for GRBs with known redshift. Since redshifts are usually measured from the optical spectrum of the afterglow, correlations between prompt and afterglow emissions may introduce biases in the distribution of rest-frame properties of the prompt emission. Our analysis is based on a sample of 90 GRBs with good optical follow-up and well measured prompt emission. 76 of them have a measure of redshift and 14 have no redshift. We estimate their optical brightness with their R magnitude measured two hours after the trigger and compare the rest frame prompt properties of different classes of GRB afterglow brightness. We find that the optical brightness of GRBs in our sample is mainly driven by their intrinsic afterglow luminosity. We show that GRBs with low and high afterglow optical fluxes have similar Epi , Eiso , Liso , indicating that the rest-frame distributions co...

  19. Combined effects of the in-plane orientation angle and the loading angle on the dynamic enhancement of honeycombs under mixed shear-compression loading

    Science.gov (United States)

    Tounsi, R.; Markiewicz, E.; Haugou, G.; Chaari, F.; Zouari, B.

    2016-05-01

    The combined effect of the loading angle (ψ) and the in-plane orientation angle (β) on the dynamic enhancement of aluminium alloy honeycombs is investigated. Experimental results are analysed on the crushing surfaces (initial peak and average crushing forces). A significant effect of the loading angle is reported. The dynamic enhancement rate depends on the loading angle until a critical loading angle (ψcritical). Beyond, a negative dynamic enhancement rate is observed. Concerning the in-plane orientation angle β effect, it depends on the loading angle ψ under quasi-static conditions. Under dynamic conditions, a significant effect is reported independently of the loading angle ψ. Therefore, the dynamic enhancement rate depends on the combined effects of ψ and β angles. A global analysis of the buckling mechanisms allowed us to explain the combined effect of ψ and β angles on the initial peak force. The collapse mechanisms analysis explain the negative dynamic enhancement rate for large loading angles.

  20. Influence of caffeine on information processing stages in well rested and fatigued subjects.

    NARCIS (Netherlands)

    L.M. Lorist; J. Snel; A. Kok

    1994-01-01

    Examined the effects of caffeine on different information processing stages using choice reaction time (RT) tasks. A 200-mg dose at the beginning and a maintenance dose of 50 mg caffeine or lactose half-way through the session were administered to 15 well-rested and 15 fatigued university students (

  1. INFLUENCE OF CAFFEINE ON SELECTIVE ATTENTION IN WELL-RESTED AND FATIGUED SUBJECTS

    NARCIS (Netherlands)

    LORIST, MM; SNEL, J; KOK, A; MULDER, G

    1994-01-01

    Effects of caffeine were studied in a visual focused selective search task in well-rested and fatigued subjects. A dose of 200 + 50 mg caffeine or placebo, dissolved in decaffeinated coffee, was administered in a double-blind and deceptive fashion. The task was to detect a target letter on one diago

  2. REST mediates androgen receptor actions on gene repression and predicts early recurrence of prostate cancer

    DEFF Research Database (Denmark)

    Svensson, Charlotte; Ceder, Jens; Iglesias Gato, Diego;

    2014-01-01

    The androgen receptor (AR) is a key regulator of prostate tumorgenesis through actions that are not fully understood. We identified the repressor element (RE)-1 silencing transcription factor (REST) as a mediator of AR actions on gene repression. Chromatin immunoprecipitation showed that AR binds...

  3. Hypnotic modulation of resting state fMRI default mode and extrinsic network connectivity.

    Science.gov (United States)

    Demertzi, A; Soddu, A; Faymonville, M-E; Bahri, M A; Gosseries, O; Vanhaudenhuyse, A; Phillips, C; Maquet, P; Noirhomme, Q; Luxen, A; Laureys, S

    2011-01-01

    Resting state fMRI (functional magnetic resonance imaging) acquisitions are characterized by low-frequency spontaneous activity in a default mode network (encompassing medial brain areas and linked to self-related processes) and an anticorrelated "extrinsic" system (encompassing lateral frontoparietal areas and modulated via external sensory stimulation). In order to better determine the functional contribution of these networks to conscious awareness, we here sought to transiently modulate their relationship by means of hypnosis. We used independent component analysis (ICA) on resting state fMRI acquisitions during normal wakefulness, under hypnotic state, and during a control condition of autobiographical mental imagery. As compared to mental imagery, hypnosis-induced modulation of resting state fMRI networks resulted in a reduced "extrinsic" lateral frontoparietal cortical connectivity, possibly reflecting a decreased sensory awareness. The default mode network showed an increased connectivity in bilateral angular and middle frontal gyri, whereas its posterior midline and parahippocampal structures decreased their connectivity during hypnosis, supposedly related to an altered "self" awareness and posthypnotic amnesia. In our view, fMRI resting state studies of physiological (e.g., sleep or hypnosis), pharmacological (e.g., sedation or anesthesia), and pathological modulation (e.g., coma or related states) of "intrinsic" default mode and anticorrelated "extrinsic" sensory networks, and their interaction with other cerebral networks, will further improve our understanding of the neural correlates of subjective awareness. PMID:21854971

  4. Multiscale entropy analysis of resting-state magnetoencephalogram with tensor factorisations in Alzheimer's disease

    DEFF Research Database (Denmark)

    Escudero, Javier; Evrim, Acar Ataman; Fernández, Alberto;

    2015-01-01

    dynamics. We consider the "refined composite multiscale entropy" (rcMSE), which computes entropy "profiles" showing levels of physiological complexity over temporal scales for individual signals. We compute the rcMSE of resting-state magnetoencephalogram (MEG) recordings from 36 patients with Alzheimer...

  5. Resting-State Retinotopic Organization in the Absence of Retinal Input and Visual Experience.

    Science.gov (United States)

    Bock, Andrew S; Binda, Paola; Benson, Noah C; Bridge, Holly; Watkins, Kate E; Fine, Ione

    2015-09-01

    Early visual areas have neuronal receptive fields that form a sampling mosaic of visual space, resulting in a series of retinotopic maps in which the same region of space is represented in multiple visual areas. It is not clear to what extent the development and maintenance of this retinotopic organization in humans depend on retinal waves and/or visual experience. We examined the corticocortical receptive field organization of resting-state BOLD data in normally sighted, early blind, and anophthalmic (in which both eyes fail to develop) individuals and found that resting-state correlations between V1 and V2/V3 were retinotopically organized for all subject groups. These results show that the gross retinotopic pattern of resting-state connectivity across V1-V3 requires neither retinal waves nor visual experience to develop and persist into adulthood. Significance statement: Evidence from resting-state BOLD data suggests that the connections between early visual areas develop and are maintained even in the absence of retinal waves and visual experience. PMID:26354906

  6. Resting-state, functional MRI on regional homogeneity changes of brain in the heavy smokers

    International Nuclear Information System (INIS)

    Objective: To explore the mechanism of self-awareness in the heavy smokers (HS) by using regional homogeneity (ReHo) combined with resting-state functional MRI (fMRI). Methods: Thirty HS and 31 healthy non-smokers (NS) matched for age and sex underwent a 3.0 T resting-state fMRI. The data were post-processed by SPM 5 and then the ReHo values were calculated by REST software. The ReHo values between the two groups were compared by two-sample t-test. The brain map with significant difference of ReHo value was obtained. Results: Compared with that in NS group, the regions with decreased ReHo value included the bilateral precuneus, superior frontal gyrus,medial prefrontal cortex, right angular gyrus, inferior frontal gyrus, inferior occipital gyrus, cerebellum, and left middle frontal gyrus in HS group. The regions of increased ReHo value included the bilateral insula, parahippocampal gyrus, white matter of parietal lobe, pons, left inferior parietal lobule, lingual gyrus, thalamus, inferior orbital gyrus, white matter of temporal-frontal lobe, and cerebellum. The difference was more obvious in the left hemisphere. Conclusions: In HS, abnormal ReHo on a resting state which reflects network of smoking addiction. This method may be helpful in understanding the mechanism of self-awareness in HS. (authors)

  7. Optical and X-ray Rest-frame Light Curves of the BAT6 sample

    CERN Document Server

    Melandri, A; Rogantini, D; Salvaterra, R; Sbarufatti, B; Bernardini, M G; Campana, S; D'Avanzo, P; D'Elia, V; Fugazza, D; Ghirlanda, G; Ghisellini, G; Nava, L; Vergani, S D; Tagliaferri, G

    2014-01-01

    We present the rest-frame light curves in the optical and X-ray bands of an unbiased and complete sample of Swift long Gamma-Ray Bursts (GRBs), namely the BAT6 sample. The unbiased BAT6 sample (consisting of 58 events) has the highest level of completeness in redshift ($\\sim$ 95%), allowing us to compute the rest-frame X-ray and optical light curves for 55 and 47 objects, respectively. We compute the X-ray and optical luminosities accounting for any possible source of absorption (Galactic and intrinsic) that could affect the observed fluxes in these two bands. We compare the behaviour observed in the X-ray and in the optical bands to assess the relative contribution of the emission during the prompt and afterglow phases. We unarguably demonstrate that the GRBs rest-frame optical luminosity distribution is not bimodal, being rather clustered around the mean value Log(L$_{R}$) = 29.9 $\\pm$ 0.8 when estimated at a rest frame time of 12 hr. This is in contrast with what found in previous works and confirms that t...

  8. Alterations of multiple resting state network connectivity in physiological, pharmacological and pathological consciousness states.

    Directory of Open Access Journals (Sweden)

    LizetteHeine

    2012-08-01

    Full Text Available In order to better understand the functional contribution of resting state activity to conscious cognition, we aimed to review increases and decreases in fMRI functional connectivity under physiological (sleep, pharmacological (anesthesia and pathological altered states of consciousness, such as brain death, coma, vegetative state/unresponsive wakefulness syndrome, and minimally conscious state. The reviewed RSNs were the DMN, left and right executive control, salience, sensorimotor, auditory and visual networks. We highlight some methodological issues concerning resting state analyses in severely injured brains mainly in terms of hypothesis-driven seed-based correlation analysis and data-driven independent components analysis approaches. Finally, we attempt to contextualize our discussion within theoretical frameworks of conscious processes. We think that this “lesion” approach allows us to better determine the necessary conditions under which normal conscious cognition takes place. At the clinical level, we acknowledge the technical merits of the resting state paradigm. Indeed, fast and easy acquisitions are preferable to activation paradigms in clinical populations. Finally, we emphasize the need to validate the diagnostic and prognostic value of fMRI resting state measurements in non-communicating brain damaged patients.

  9. Evolution of the jet opening angle distribution in holographic plasma

    CERN Document Server

    Rajagopal, Krishna; van der Schee, Wilke

    2016-01-01

    We use holography to analyze the evolution of an ensemble of jets, with an initial probability distribution for their energy and opening angle as %for jets in proton-proton (pp) collisions, as they propagate through an expanding cooling droplet of strongly coupled plasma as in heavy ion collisions. We identify two competing effects: (i) each individual jet widens as it propagates; (ii) the opening angle distribution for jets emerging from the plasma within any specified range of energies has been pushed toward smaller angles, comparing to pp jets with the same energies. The second effect arises because small-angle jets suffer less energy loss and because jets with a higher initial energy are less probable in the ensemble. We illustrate both effects in a simple two-parameter model, and find that their consequence in sum is that the opening angle distribution for jets in any range of energies contains fewer narrow and wide jets. Either effect can dominate in the mean opening angle, for not unreasonable values o...

  10. Effect of scanner acoustic background noise on strict resting-state fMRI

    Directory of Open Access Journals (Sweden)

    C. Rondinoni

    2013-04-01

    Full Text Available Functional MRI (fMRI resting-state experiments are aimed at identifying brain networks that support basal brain function. Although most investigators consider a ‘resting-state' fMRI experiment with no specific external stimulation, subjects are unavoidably under heavy acoustic noise produced by the equipment. In the present study, we evaluated the influence of auditory input on the resting-state networks (RSNs. Twenty-two healthy subjects were scanned using two similar echo-planar imaging sequences in the same 3T MRI scanner: a default pulse sequence and a reduced “silent” pulse sequence. Experimental sessions consisted of two consecutive 7-min runs with noise conditions (default or silent counterbalanced across subjects. A self-organizing group independent component analysis was applied to fMRI data in order to recognize the RSNs. The insula, left middle frontal gyrus and right precentral and left inferior parietal lobules showed significant differences in the voxel-wise comparison between RSNs depending on noise condition. In the presence of low-level noise, these areas Granger-cause oscillations in RSNs with cognitive implications (dorsal attention and entorhinal, while during high noise acquisition, these connectivities are reduced or inverted. Applying low noise MR acquisitions in research may allow the detection of subtle differences of the RSNs, with implications in experimental planning for resting-state studies, data analysis, and ergonomic factors.

  11. Visual Learning Alters the Spontaneous Activity of the Resting Human Brain: An fNIRS Study

    Directory of Open Access Journals (Sweden)

    Haijing Niu

    2014-01-01

    Full Text Available Resting-state functional connectivity (RSFC has been widely used to investigate spontaneous brain activity that exhibits correlated fluctuations. RSFC has been found to be changed along the developmental course and after learning. Here, we investigated whether and how visual learning modified the resting oxygenated hemoglobin (HbO functional brain connectivity by using functional near-infrared spectroscopy (fNIRS. We demonstrate that after five days of training on an orientation discrimination task constrained to the right visual field, resting HbO functional connectivity and directed mutual interaction between high-level visual cortex and frontal/central areas involved in the top-down control were significantly modified. Moreover, these changes, which correlated with the degree of perceptual learning, were not limited to the trained left visual cortex. We conclude that the resting oxygenated hemoglobin functional connectivity could be used as a predictor of visual learning, supporting the involvement of high-level visual cortex and the involvement of frontal/central cortex during visual perceptual learning.

  12. Effect of scanner acoustic background noise on strict resting-state fMRI

    Directory of Open Access Journals (Sweden)

    C. Rondinoni

    2013-12-01

    Full Text Available Functional MRI (fMRI resting-state experiments are aimed at identifying brain networks that support basal brain function. Although most investigators consider a ‘resting-state' fMRI experiment with no specific external stimulation, subjects are unavoidably under heavy acoustic noise produced by the equipment. In the present study, we evaluated the influence of auditory input on the resting-state networks (RSNs. Twenty-two healthy subjects were scanned using two similar echo-planar imaging sequences in the same 3T MRI scanner: a default pulse sequence and a reduced “silent” pulse sequence. Experimental sessions consisted of two consecutive 7-min runs with noise conditions (default or silent counterbalanced across subjects. A self-organizing group independent component analysis was applied to fMRI data in order to recognize the RSNs. The insula, left middle frontal gyrus and right precentral and left inferior parietal lobules showed significant differences in the voxel-wise comparison between RSNs depending on noise condition. In the presence of low-level noise, these areas Granger-cause oscillations in RSNs with cognitive implications (dorsal attention and entorhinal, while during high noise acquisition, these connectivities are reduced or inverted. Applying low noise MR acquisitions in research may allow the detection of subtle differences of the RSNs, with implications in experimental planning for resting-state studies, data analysis, and ergonomic factors.

  13. Effect of 5 weeks horizontal bed rest on human muscle thickness and architecture of weight bearing and non-weight bearing muscles

    OpenAIRE

    de Boer, Maarten D.; Seynnes, Olivier; Prampero, Pietro di; Pišot, Rado; Mekjavić, Igor B.; Biolo, Gianni; Narici, Marco

    2013-01-01

    The aim of the present study was to investigate the changes in thickness, fascicle length (L f) and pennation angle of the antigravity gastrocnemiusmedialis (GM) and vastus lateralis (VL) muscles, and the non-antigravity tibialis anterior (TA) and biceps brachii (BB) muscles measured by ultrasonography in ten healthy males (aged 22.3 +/- 2.2 years) in response to 5 weeks of horizontal bed rest (BR). After BR, muscle thickness decreased by 12.2 +/- 8.8% (P < 0.05) and 8.0 +/- 9.1% (P < 0.005) ...

  14. Utility of resting fMRI and connectivity in patients with brain tumor

    Directory of Open Access Journals (Sweden)

    Sandhya Manglore

    2013-01-01

    Full Text Available Background: Resting state (task independent Functional Magnetic Resonance Imaging (fMRI has opened a new avenue in cognitive studies and has found practical clinical applications. Materials and Methods: Resting fMRI analysis was performed in six patients with brain tumor in the motor cortex. For comparison, task-related mapping of the motor cortex was done. Connectivity analysis to study the connections and strength of the connections between the primary motor cortex, premotor cortex, and primary somatosensory cortex on the affected side was also performed and compared with the contralateral normal side and the controls. Results: Resting fMRI in patients with brain tumor in the motor cortex mapped the motor cortex in a task-free state and the results were comparable to the motor task paradigm. Decreased connectivity on the tumor-affected side was observed, as compared to the unaffected side. Conclusion: Resting fMRI and connectivity analysis are useful in the presurgical evaluation of patients with brain tumors and may help in uncooperative or pediatric patients. They can also prognosticate the postoperative outcome. This method also has significant applications due to the ease of image acquisition.

  15. Consistency of network modules in resting-state FMRI connectome data.

    Directory of Open Access Journals (Sweden)

    Malaak N Moussa

    Full Text Available At rest, spontaneous brain activity measured by fMRI is summarized by a number of distinct resting state networks (RSNs following similar temporal time courses. Such networks have been consistently identified across subjects using spatial ICA (independent component analysis. Moreover, graph theory-based network analyses have also been applied to resting-state fMRI data, identifying similar RSNs, although typically at a coarser spatial resolution. In this work, we examined resting-state fMRI networks from 194 subjects at a voxel-level resolution, and examined the consistency of RSNs across subjects using a metric called scaled inclusivity (SI, which summarizes consistency of modular partitions across networks. Our SI analyses indicated that some RSNs are robust across subjects, comparable to the corresponding RSNs identified by ICA. We also found that some commonly reported RSNs are less consistent across subjects. This is the first direct comparison of RSNs between ICAs and graph-based network analyses at a comparable resolution.

  16. Clinical evaluation of lung rest/stress perfusion scintigraphy in patients with severe emphysema

    International Nuclear Information System (INIS)

    Volume lung reduction surgery (LVRS) improves lung function and physical tolerance for selected patients with severe pulmonary emphysema by making conditions for developing of the vital parenchyma so far compressed by the emphysema blisters. The aim of this study was to establish the comparative functional information obtained from REST/STRESS lung perfusion tomoscintigraphies for identification of non functional lung tissue. Eleven patients (8 males and 3 females at age 41-60) were examined by two lung perfusions SPECT scintigraphies after intravenous application of 222 MBq 99mTc-MAA: 1. after 30 min. lying rest and 2. 48 hours later after 6 min. walk test. Comparing the two scintigraphies the following changes in perfusion performance have been established at STRESS examination: increased at six patients (significant at three and slight also at three) and decreased at two. There was no difference between REST and STRESS examinations at 3 patients. Comparative REST/STRESS lung perfusion scintigraphy is important method for screening severe pulmonary patients for LVRS. (author)

  17. A generic implementation of replica exchange with solute tempering (REST2) algorithm in NAMD for complex biophysical simulations

    Science.gov (United States)

    Jo, Sunhwan; Jiang, Wei

    2015-12-01

    Replica Exchange with Solute Tempering (REST2) is a powerful sampling enhancement algorithm of molecular dynamics (MD) in that it needs significantly smaller number of replicas but achieves higher sampling efficiency relative to standard temperature exchange algorithm. In this paper, we extend the applicability of REST2 for quantitative biophysical simulations through a robust and generic implementation in greatly scalable MD software NAMD. The rescaling procedure of force field parameters controlling REST2 "hot region" is implemented into NAMD at the source code level. A user can conveniently select hot region through VMD and write the selection information into a PDB file. The rescaling keyword/parameter is written in NAMD Tcl script interface that enables an on-the-fly simulation parameter change. Our implementation of REST2 is within communication-enabled Tcl script built on top of Charm++, thus communication overhead of an exchange attempt is vanishingly small. Such a generic implementation facilitates seamless cooperation between REST2 and other modules of NAMD to provide enhanced sampling for complex biomolecular simulations. Three challenging applications including native REST2 simulation for peptide folding-unfolding transition, free energy perturbation/REST2 for absolute binding affinity of protein-ligand complex and umbrella sampling/REST2 Hamiltonian exchange for free energy landscape calculation were carried out on IBM Blue Gene/Q supercomputer to demonstrate efficacy of REST2 based on the present implementation.

  18. Recognizing mild cognitive impairment based on network connectivity analysis of resting EEG with zero reference

    International Nuclear Information System (INIS)

    The diagnosis of mild cognitive impairment (MCI) is very helpful for early therapeutic interventions of Alzheimer's disease (AD). MCI has been proven to be correlated with disorders in multiple brain areas. In this paper, we used information from resting brain networks at different EEG frequency bands to reliably recognize MCI. Because EEG network analysis is influenced by the reference that is used, we also evaluate the effect of the reference choices on the resting scalp EEG network-based MCI differentiation. The conducted study reveals two aspects: (1) the network-based MCI differentiation is superior to the previously reported classification that uses coherence in the EEG; and (2) the used EEG reference influences the differentiation performance, and the zero approximation technique (reference electrode standardization technique, REST) can construct a more accurate scalp EEG network, which results in a higher differentiation accuracy for MCI. This study indicates that the resting scalp EEG-based network analysis could be valuable for MCI recognition in the future. (paper)

  19. TET3 Is Recruited by REST for Context-Specific Hydroxymethylation and Induction of Gene Expression

    Directory of Open Access Journals (Sweden)

    Arshan Perera

    2015-04-01

    Full Text Available Ten-eleven translocation hydroxylases (TET1-3 oxidize 5-methylcytosine (5mC to 5-hydroxymethylcytosine (5hmC. In neurons, increased 5hmC levels within gene bodies correlate positively with gene expression. The mechanisms controlling TET activity and 5hmC levels are poorly understood. In particular, it is not known how the neuronal TET3 isoform lacking a DNA-binding domain is targeted to the DNA. To identify factors binding to TET3, we screened for proteins that co-precipitate with TET3 from mouse retina and identified the transcriptional repressor REST as a highly enriched TET3-specific interactor. REST was able to enhance TET3 hydroxylase activity after co-expression and overexpression of TET3-activated transcription of REST target genes. Moreover, we found that TET3 also interacts with NSD3 and two other H3K36 methyltransferases and is able to induce H3K36 trimethylation. We propose a mechanism for transcriptional activation in neurons that involves REST-guided targeting of TET3 to the DNA for directed 5hmC generation and NSD3-mediated H3K36 trimethylation.

  20. Angle-Resolved Plasmonic Properties of Single Gold Nanorod Dimers

    Institute of Scientific and Technical Information of China (English)

    Jian Wu; Xuxing Lu; Qiannan Zhu; Junwei Zhao; Qishun Shen; Li Zhan; Weihai Ni

    2014-01-01

    Through wet-chemical assembly methods, gold nanorods were placed close to each other and formed a dimer with a gap distance*1 nm, and hence degenerated plasmonic dipole modes of individual nanorods coupled together to produce hybridized bonding and antibonding resonance modes. Previous studies using a condenser for illumination result in averaged signals over all excitation angles. By exciting an individual dimer obliquely at different angles, we demonstrate that these two new resonance modes are highly tunable and sensitive to the angle between the excitation polarization and the dimer orientation, which follows cos2u dependence. Moreover, for dimer structures with various structure angles, the resonance wavelengths as well as the refractive index sensitivities were found independent of the structure angle. Cal-culated angle-resolved plasmonic properties are in good agreement with the measurements. The assembled nanostructures investigated here are important for fundamental researches as well as potential applications when they are used as building blocks in plasmon-based optical and optoelectronic devices.

  1. Tendon vibration attenuates superficial venous vessel response of the resting limb during static arm exercise

    Directory of Open Access Journals (Sweden)

    Ooue Anna

    2012-11-01

    Full Text Available Abstract Background The superficial vein of the resting limb constricts sympathetically during exercise. Central command is the one of the neural mechanisms that controls the cardiovascular response to exercise. However, it is not clear whether central command contributes to venous vessel response during exercise. Tendon vibration during static elbow flexion causes primary muscle spindle afferents, such that a lower central command is required to achieve a given force without altering muscle force. The purpose of this study was therefore to investigate whether a reduction in central command during static exercise with tendon vibration influences the superficial venous vessel response in the resting limb. Methods Eleven subjects performed static elbow flexion at 35% of maximal voluntary contraction with (EX + VIB and without (EX vibration of the biceps brachii tendon. The heart rate, mean arterial pressure, and rating of perceived exertion (RPE in overall and exercising muscle were measured. The cross-sectional area (CSAvein and blood velocity of the basilic vein in the resting upper arm were assessed by ultrasound, and blood flow (BFvein was calculated using both variables. Results Muscle tension during exercise was similar between EX and EX + VIB. However, RPEs at EX + VIB were lower than those at EX (P P vein in the resting limb at EX decreased during exercise from baseline (P vein at EX + VIB did not change during exercise. CSAvein during exercise at EX was smaller than that at EX + VIB (P vein did not change during the protocol under either condition. The decreases in circulatory response and RPEs during EX + VIB, despite identical muscle tension, showed that activation of central command was less during EX + VIB than during EX. Abolishment of the decrease in CSAvein during exercise at EX + VIB may thus have been caused by a lower level of central command at EX + VIB rather than EX. Conclusion Diminished central command induced by tendon

  2. Computerized two-lead resting ECG analysis for the detection of coronary artery stenosis

    Directory of Open Access Journals (Sweden)

    Eberhard Grube, Andreas Bootsveld, Seyrani Yuecel, Joseph T. Shen, Michael Imhoff

    2007-01-01

    Full Text Available Background: Resting electrocardiogram (ECG shows limited sensitivity and specificity for the detection of coronary artery disease (CAD. Several methods exist to enhance sensitivity and specificity of resting ECG for diagnosis of CAD, but such methods are not better than a specialist's judgement. We compared a new computer-enhanced, resting ECG analysis device, 3DMP, to coronary angiography to evaluate the device's accuracy in detecting hemodynamically relevant CAD. Methods: A convenience sample of 423 patients without prior coronary revascularization was evaluated with 3DMP before coronary angiography. 3DMP's sensitivity and specificity in detecting hemodynamically relevant coronary stenosis as diagnosed with coronary angiography were calculated as well as odds ratios for the 3DMP severity score and coronary artery disease risk factors. Results: 3DMP identified 179 of 201 patients with hemodynamically relevant stenosis (sensitivity 89.1%, specificity 81.1%. The positive and negative predictive values for identification of coronary stenosis as diagnosed in coronary angiograms were 79% and 90% respectively. CAD risk factors in a logistic regression model had markedly lower predictive power for the presence of coronary stenosis in patients than did 3DMP severity score (odds ratio 3.35 [2.24-5.01] vs. 34.87 [20.00-60.79]. Logistic regression combining severity score with risk factors did not add significantly to the prediction quality (odds ratio 36.73 [20.92-64.51]. Conclusions: 3DMP's computer-based, mathematically derived analysis of resting two-lead ECG data provides detection of hemodynamically relevant CAD with high sensitivity and specificity that appears to be at least as good as those reported for other resting and/or stress ECG methods currently used in clinical practice.

  3. Neural correlates of verbal creativity: Differences in resting-state functional connectivity associated with expertise in creative writing

    OpenAIRE

    Martin Lotze; Simon Eickhoff

    2014-01-01

    Neural characteristics of verbal creativity as assessed by word generation tasks have been recently identified, but differences in resting-state functional connectivity (rFC) between experts and non-experts in creative writing have not been reported yet. Previous electroencephalography (EEG) coherence measures during rest demonstrated a decreased cooperation between brain areas in association with creative thinking ability. Here, we used resting-state functional magnetic resonance imaging to ...

  4. Neural correlates of verbal creativity: differences in resting-state functional connectivity associated with expertise in creative writing

    OpenAIRE

    Lotze, Martin; Erhard, Katharina; Neumann, Nicola; Simon B. Eickhoff; Langner, Robert

    2014-01-01

    Neural characteristics of verbal creativity as assessed by word generation tasks have been recently identified, but differences in resting-state functional connectivity (rFC) between experts and non-experts in creative writing have not been reported yet. Previous electroencephalography (EEG) coherence measures during rest demonstrated a decreased cooperation between brain areas in association with creative thinking ability. Here, we used resting-state functional magnetic resonance imaging to ...

  5. Ergonomic Evaluation of the Angle of Abduction in Laptops Environment

    Directory of Open Access Journals (Sweden)

    Imtiaz Ali Khan

    2016-01-01

    Full Text Available Laptops in 21st century are an integral part of every professional in vivid fields. Off late there has been emergence of several ergonomic injuries such as repetitive strain injuries (RSIs due to extensive usage of laptops, which can be closely linked with applied force and postures. This study investigated the effect of various angles of keyboard on the applied force and motor action plus response time while performing five distinct tasks. On the basis of literature two different laptops were selected for performing different tasks. For each case the three levels of platform angle were considered as 0°, 5°, and 10°. Male subjects were selected to perform five distinct tasks for each platform angle for both laptops. The force applied (in milli-volts and the motor action plus response time (milli-seconds were recorded using an oscilloscope. The data collected were analyzed through ANOVA using MINITAB software. The abduction angle with the least mean response time and applied force were considered as the best from ergonomics viewpoint. The ANOVA results showed that the angle of abduction for both laptops (small and large do have significant effect on applied force but not on motor action plus response time. The analysis of results indicate that 10° angle of abduction in case of small laptops should be applied to minimize musculoskeletal disorder and repetitive strain injuries. Research relevance: This work suggests that those responsible for the function and operation of laptops would have to redesign the system to reduce injuries, as far as musculoskeletal disorder, repetitive strain injuries and other related problems are concerned. The present work can be quite useful for the system designers of tomorrow.

  6. Functional connectivity of the dorsal and median raphe nuclei at rest.

    Science.gov (United States)

    Beliveau, Vincent; Svarer, Claus; Frokjaer, Vibe G; Knudsen, Gitte M; Greve, Douglas N; Fisher, Patrick M

    2015-08-01

    Serotonin (5-HT) is a neurotransmitter critically involved in a broad range of brain functions and implicated in the pathophysiology of neuropsychiatric illnesses including major depression, anxiety and sleep disorders. Despite being widely distributed throughout the brain, there is limited knowledge on the contribution of 5-HT to intrinsic brain activity. The dorsal raphe (DR) and median raphe (MR) nuclei are the source of most serotonergic neurons projecting throughout the brain and thus provide a compelling target for a seed-based probe of resting-state activity related to 5-HT. Here we implemented a novel multimodal neuroimaging approach for investigating resting-state functional connectivity (FC) between DR and MR and cortical, subcortical and cerebellar target areas. Using [(11)C]DASB positron emission tomography (PET) images of the brain serotonin transporter (5-HTT) combined with structural MRI from 49 healthy volunteers, we delineated DR and MR and performed a seed-based resting-state FC analysis. The DR and MR seeds produced largely similar FC maps: significant positive FC with brain regions involved in cognitive and emotion processing including anterior cingulate, amygdala, insula, hippocampus, thalamus, basal ganglia and cerebellum. Significant negative FC was observed within pre- and postcentral gyri for the DR but not for the MR seed. We observed a significant association between DR and MR FC and regional 5-HTT binding. Our results provide evidence for a resting-state network related to DR and MR and comprising regions receiving serotonergic innervation and centrally involved in 5-HT related behaviors including emotion, cognition and reward processing. These findings provide a novel advance in estimating resting-state FC related to 5-HT signaling, which can benefit our understanding of its role in behavior and neuropsychiatric illnesses. PMID:25963733

  7. Loss of resting bradycardia with detraining is associated with intrinsic heart rate changes

    Directory of Open Access Journals (Sweden)

    Evangelista F.S.

    2005-01-01

    Full Text Available The mechanisms underlying the loss of resting bradycardia with detraining were studied in rats. The relative contribution of autonomic and non-autonomic mechanisms was studied in 26 male Wistar rats (180-220 g randomly assigned to four groups: sedentary (S, N = 6, trained (T, N = 8, detrained for 1 week (D1, N = 6, and detrained for 2 weeks (D2, N = 6. T, D1 and D2 were treadmill trained 5 days/week for 60 min with a gradual increase towards 50% peak VO2. After the last training session, D1 and D2 were detrained for 1 and 2 weeks, respectively. The effect of the autonomic nervous system in causing training-induced resting bradycardia and in restoring heart rate (HR to pre-exercise training level (PET with detraining was examined indirectly after cardiac muscarinic and adrenergic receptor blockade. T rats significantly increased peak VO2 by 15 or 23.5% when compared to PET and S rats, respectively. Detraining reduced peak VO2 in both D1 and D2 rats by 22% compared to T rats, indicating loss of aerobic capacity. Resting HR was significantly lower in T and D1 rats than in S rats (313 ± 6.67 and 321 ± 6.01 vs 342 ± 12.2 bpm and was associated with a significantly decreased intrinsic HR (368 ± 6.1 and 362 ± 7.3 vs 390 ± 8 bpm. Two weeks of detraining reversed the resting HR near PET (335 ± 6.01 bpm due to an increased intrinsic HR in D2 rats compared with T and D1 rats (376 ± 8.8 bpm. The present study provides the first evidence of intrinsic HR-mediated loss of resting bradycardia with detraining in rats.

  8. Standardised Resting Time Prior to Blood Sampling and Diurnal Variation Associated with Risk of Patient Misclassification

    DEFF Research Database (Denmark)

    Andersen, Ida B.; Brasen, Claus L.; Christensen, Henry; Nøhr-Jensen, Lene; Nielsen, Dorthe E.; Brandslund, Ivan; Madsen, Jonna S.

    2015-01-01

    impact of resting time prior to blood sampling and diurnal variation on biochemical components, including albumin, thyrotropin (TSH), total calcium and sodium in plasma. METHODS: All patients referred to an outpatient clinic for blood sampling were included in the period Nov 2011 until June 2014 (opening......: Significant diurnal variation was found for albumin (n = 15,544; p<2×10-16), TSH (n = 20,019; p<2×10-16), calcium (n = 13,588; p = 2.8×10-12) and sodium (n = 51,917; p<2×10-16). Further significant influence for resting time was found for albumin (p = 2.6×10-4), TSH (p = 0.004), calcium (p = 8.9×10-7) and...... sodium (p = 8.7×10-16). Only TSH and albumin were clinically significantly influenced by diurnal variation. Resting time had no clinically significant effect. CONCLUSIONS: We found no need for resting 15 minutes prior to blood sampling. However, diurnal variation was found to have a significant and...

  9. Doppler angle correction in the measurement of intrarenal parameters

    Directory of Open Access Journals (Sweden)

    Mennitt K

    2011-03-01

    Full Text Available Jing Gao¹, Keith Hentel¹, Qiang Zhu², Teng Ma², George Shih¹, Kevin Mennitt¹, Robert Min¹¹Department of Radiology, New York Presbyterian Hospital, Weill Cornell Medical College, NY, USA; ²Division of Diagnostic Ultrasound, Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, ChinaBackground: The aim of this study was to assess differences in intrarenal artery Doppler parameters measured without and with Doppler angle correction.Methods: We retrospectively reviewed color duplex sonography in 30 normally functioning kidneys (20 native kidneys in 10 subjects and 10 transplanted kidneys in 10 subjects performed between January 26, 2010 and July 26, 2010. There were 10 age-matched men and10 age-matched women (mean 39.8 ± 12.2, range 21–60 years in this study. Depending on whether the Doppler angle was corrected in the spectral Doppler measurement, Doppler parameters including peak systolic velocity (PSV, end-diastolic velocity (EDV, and resistive index (RI measured at the interlobar artery of the kidney were divided into two groups, ie, initial Doppler parameters measured without Doppler angle correction (Group 1 and remeasured Doppler parameters with Doppler angle correction (Group 2. Values for PSV, EDV, and RI measured without Doppler angle correction were compared with those measured with Doppler angle correction, and were analyzed statistically with a paired-samples t-test.Results: There were statistical differences in PSV and EDV at the interlobar artery in the upper, mid, and lower poles of the kidney between Group 1 and Group 2 (all P < 0.001. PSV and EDV in Group 1 were significantly lower than in Group 2. RI in Group 1 was the same as that in Group 2 in the upper, mid, and lower poles of the kidneys.Conclusion: Doppler angle correction plays an important role in the accurate measurement of intrarenal blood flow velocity. The true flow velocity converted from the maximum Doppler velocity shift

  10. Patterns and perceptions of migration, is Scotland distinct from the rest of the UK?

    OpenAIRE

    McCollum, David; Findlay, Allan; Bell, David; Bijak, Jakub

    2013-01-01

    The forthcoming referendum on the constitutional future of Scotland has inevitably been the focus of considerable public debate. The issue of migration has not featured strongly in these discussions. However there are grounds for believing that Scotland is ‘different’ from the rest of the UK in terms of migration patterns and in relation to public attitudes towards immigration. This briefing introduces some of the issues that are being addressed by an ESRC Centre for Population Change study i...

  11. Effect of temperature on body temperature and resting metabolic rate in pups of Eothenomys miletus

    OpenAIRE

    Zhu, Wan-long; Mu, Yuan; Zhang, Lin; Wang, Zheng-Kun

    2013-01-01

    In order to investigate the ability of ambient temperature and thermoregulation in Eothenomys miletus, body temperature and resting metabolic rate (RMR) were measured during postnatal development (1-49 day) when E. miletus exposed different ambient temperature. The result showed that: body temperature and RMR of pups in E. miletus increased according to the increase of ambient temperature during 1 day to 7 day, showed character of poikilotherms; body temperature of pups were lower in low tem...

  12. Scoliosis angle

    International Nuclear Information System (INIS)

    The most commonly used methods of assessing the scoliotic deviation measure angles that are not clearly defined in relation to the anatomy of the patient. In order to give an anatomic basis for such measurements it is proposed to define the scoliotic deviation as the deviation the vertebral column makes with the sagittal plane. Both the Cobb and the Ferguson angles may be based on this definition. The present methods of measurement are then attempts to measure these angles. If the plane of these angles is parallel to the film, the measurement will be correct. Errors in the measurements may be incurred by the projection. A hypothetical projection, called a 'rectified orthogonal projection', is presented, which correctly represents all scoliotic angles in accordance with these principles. It can be constructed in practice with the aid of a computer and by performing measurements on two projections of the vertebral column; a scoliotic curve can be represented independent of the kyphosis and lordosis. (Auth.)

  13. The Resting Motor Threshold - Restless or Resting?

    DEFF Research Database (Denmark)

    Karabanov, Anke Ninija; Raffin, Estelle Emeline; Siebner, Hartwig Roman

    2015-01-01

    Background The resting motor threshold (RMT) is used to individually adjust the intensity of transcranial magnetic stimulation (TMS) intensity and is assumed to be stable. Here we challenge this notion by showing that RMT expresses acute context-dependent fluctuations. Method In twelve participan...... captured online by threshold hunting. These fluctuations need to be considered when RMT is used to individually adjust TMS intensity for plasticity-inducing protocols....

  14. Origin of Hinge-Like Mechanism in Single-Layer Black Phosphorus: the Angle-Angle Cross Interaction

    OpenAIRE

    Jiang, Jin-Wu

    2016-01-01

    The single-layer black phosphorus is characteristic for its puckered configuration that possesses the hinge-like mechanism, which leads to the highly anisotropic in-plane Poisson's ratios and the negative out-of-plane Poisson's ratio. We reveal that the hinge-like mechanism can be attributed to the angle-angle cross interaction, which, combined with the bond stretching and angle bending interactions, is able to provide a good description of the mechanical properties in the single-layer black ...

  15. Rest-frame UV versus optical morphologies of galaxies using Sersic profile fitting: the importance of morphological K-correction

    CERN Document Server

    Rawat, Abhishek; De Mello, Duilia

    2009-01-01

    We show a comparison of the rest-frame UV morphologies of a sample of 162 intermediate redshift (median redshift 1.02) galaxies with their rest-frame optical morphologies. We select our sample from the deepest near-UV image obtained with the Hubble Space Telescope (HST) using the WFPC2 (F300W) as part of the parallel observations of the Hubble Ultra Deep Field campaign overlapping with the HST/ACS GOODS dataset. We perform single component Sersic fits in both WFPC2/F300W (rest-frame UV) and ACS/F850LP (rest-frame optical) bands and deduce that the Sersic index $n$ is estimated to be smaller in the rest-frame UV compared to the rest-frame optical, leading to an overestimation of the number of merger candidates by ~40-100% compared to the rest-frame optical depending upon the cutoff in $n$ employed for identifying merger candidates. This effect seems to be dominated by galaxies with low values of n(F300W) = 0.8) objects are higher by a factor of ~2.8 compared to the rest-fram e optical. This indicates that the ...

  16. Activation of resting human T cells requires prolonged stimulation of protein kinase C.

    OpenAIRE

    Berry, N; Ase, K; Kishimoto, A.; Nishizuka, Y

    1990-01-01

    Purified resting human T cells can be induced to express the alpha subunit of the interleukin 2 receptor and to proliferate by treatment with 12-O-tetradecanoylphorbol-13-acetate plus ionomycin but not with 1,2-dioctanoylglycerol plus ionomycin. Determination of the translocation of protein kinase C showed that 12-O-tetradecanoylphorbol-13-acetate plus ionomycin caused a prolonged membrane association of the enzyme for more than 4 hr, whereas 1,2-dioctanoylglycerol plus ionomycin induced a tr...

  17. Unexpected increases in rotifer resting egg abundances during the period of contamination of Lake Orta

    OpenAIRE

    Piscia, Roberta; Tabozzi, Simone; Roberta BETTINETTI; Liisa NEVALAINEN; Manca, Marina M.

    2016-01-01

    Despite their ecological importance and rapid response to environmental changes, rotifers are rarely included in palaeolimnological studies. Here, we describe changes in abundance (ABD) and morphotype (MTs) diversity of rotifer resting eggs in the sediments of deep subalpine Lake Orta, Italy, covering a period prior to (pre-) 1926, during long-term ammonia and metal pollution from a rayon factory, and subsequent recovery of water quality. Following the pollution and bacterial oxidation of the...

  18. Test-retest reliability of graph metrics of resting state MRI functional brain networks: A review.

    Science.gov (United States)

    Andellini, Martina; Cannatà, Vittorio; Gazzellini, Simone; Bernardi, Bruno; Napolitano, Antonio

    2015-09-30

    The employment of graph theory to analyze spontaneous fluctuations in resting state BOLD fMRI data has become a dominant theme in brain imaging studies and neuroscience. Analysis of resting state functional brain networks based on graph theory has proven to be a powerful tool to quantitatively characterize functional architecture of the brain and it has provided a new platform to explore the overall structure of local and global functional connectivity in the brain. Due to its increased use and possible expansion to clinical use, it is essential that the reliability of such a technique is very strongly assessed. In this review, we explore the outcome of recent studies in network reliability which apply graph theory to analyze connectome resting state networks. Therefore, we investigate which preprocessing steps may affect reproducibility the most. In order to investigate network reliability, we compared the test-retest (TRT) reliability of functional data of published neuroimaging studies with different preprocessing steps. In particular we tested influence of global signal regression, correlation metric choice, binary versus weighted link definition, frequency band selection and length of time-series. Statistical analysis shows that only frequency band selection and length of time-series seem to affect TRT reliability. Our results highlight the importance of the choice of the preprocessing steps to achieve more reproducible measurements. PMID:26072249

  19. Plankton Resting Stages in the Marine Sediments of the Bay of Vlorë (Albania

    Directory of Open Access Journals (Sweden)

    Fernando Rubino

    2013-01-01

    Full Text Available In the frame of the INTERREG III CISM project, sediment cores were collected at 2 stations in the Gulf of Vlorë to study the plankton resting stage assemblages. A total of 87 morphotypes were identified and produced by Dinophyta, Ciliophora, Rotifera, and Crustacea. In 22 cases, the cyst belonged to a species absent from the plankton of the same period. The most abundant resting stages were those produced by Scrippsiella species (Dinophyta. Some calcareous cysts were identified as fossil species associated with Pleistocene to Pliocene sediment, although they were also found in surface sediments and some of them successfully germinated, thus proving their modern status. Total abundance generally decreased with sediment depth at station 40, while station 45 showed distinct maxima at 3 and 8 cm below the sediment surface. The depth of peak abundance in the sediment varied with species. This paper presents the first study of the plankton resting stages in the Bay of Vlorë. The study confirmed the utility of this type of investigation for a more correct evaluation of species diversity. In addition, the varying distribution with sediment depth suggests that this field could be of some importance in determining the history of species assemblages.

  20. Combined effects of air temperature, wind, and radiation on the resting metabolism of avian raptors

    International Nuclear Information System (INIS)

    American kestrels, Falco sparverius; red-tailed hawks, Buteo jamaicensis; and golden eagles, Aquila chrysaetos, were perched in a wind tunnel and subjected to various combinations of air temperature, wind, and radiation. Oxygen consumption was measured under the various combinations of environmental variables, and multiple regression equations were developed to predict resting metabolism as a function of body mass, air temperature, wind speed, and radiation load

  1. Dataset of gene cloning and gel filtration chromatography of R-est6.

    Science.gov (United States)

    Soni, Surabhi; Odaneth, Annamma A; Lali, Arvind M; Chandrayan, Sanjeev K

    2016-06-01

    The data presented in this article are connected to the research article entitled "Expression, purification and biochemical characterization of a family 6 carboxylesterase from Methylococcus capsulatus (bath)" (Soni et al., 2016 [1]). The family 6 carboxylesterases are the smallest and display broad substrate specificity. The 1 kb gene encoding, a family 6 carboxylesterase - R-est6, was amplified from the genome of M. capsulatus (bath strain), and showed in the agarose gel. The corresponding purified protein, after overexpression in Escherichia coli, was biochemically studied in the research article (Soni et al., 2016 [1]). R-est6 has hydrophobic patches on the surface so, it is expected to show oligimeric forms. Here, we have confirmed the presence of oligomers by gel filtration chromatography data and the proteins belonging to the different peaks are shown on a SDS-PAGE. PMID:27222859

  2. Numerical study of hub taper angle on podded propeller performance

    International Nuclear Information System (INIS)

    Presently, the majority of podded propulsion systems are of the pulling type, because this type provides better hydrodynamic efficiency than the pushing type. There are several possible explanations for the better overall performance of a puller type podded propulsor. One is related to the difference in hub shape. Puller and pusher propellers have opposite hub taper angles, hence different hub and blade root shape. These differences cause changes in the flow condition and possibly influence the overall performance. The current study focuses on the variation in performance of pusher and puller propellers with the same blade sections, but different hub taper angles. A hyperboloidal low order source doublet steady/unsteady time domain panel method code was modified and used to evaluate effects of hub taper angle on the open water propulsive performance of some fixed pitch screw propellers used in podded propulsion systems. The modified code was first validated against measurements of two model propellers in terms of average propulsive performance and good agreement was found. Major findings include significant effects of hub taper angle on propulsive performance of tapered hub propellers and noticeable effects of hub taper angle on sectional pressure distributions of tapered hub propeller blades. (author)

  3. Numerical study of hub taper angle on podded propeller performance

    Energy Technology Data Exchange (ETDEWEB)

    Islam, M.F.; Veitch, B.; Bose, N. [Memorial Univ. of Newfoundland, Faculty of Engineering and Applied Science, St. John' s, Newfoundland (Canada)]. E-mail: Mohammed.Islam@nrc-cnrc.gc.ca; Liu, P. [National Research Council of Canada, Inst. for Ocean Technology (IOT), St. John' s, Newfoundland (Canada)

    2005-07-01

    Presently, the majority of podded propulsion systems are of the pulling type, because this type provides better hydrodynamic efficiency than the pushing type. There are several possible explanations for the better overall performance of a puller type podded propulsor. One is related to the difference in hub shape. Puller and pusher propellers have opposite hub taper angles, hence different hub and blade root shape. These differences cause changes in the flow condition and possibly influence the overall performance. The current study focuses on the variation in performance of pusher and puller propellers with the same blade sections, but different hub taper angles. A hyperboloidal low order source doublet steady/unsteady time domain panel method code was modified and used to evaluate effects of hub taper angle on the open water propulsive performance of some fixed pitch screw propellers used in podded propulsion systems. The modified code was first validated against measurements of two model propellers in terms of average propulsive performance and good agreement was found. Major findings include significant effects of hub taper angle on propulsive performance of tapered hub propellers and noticeable effects of hub taper angle on sectional pressure distributions of tapered hub propeller blades. (author)

  4. Multi angle view of lung using optical coherence tomography (OCT)

    Science.gov (United States)

    Golabchi, Ali; DiMarzio, Charles A.; Gouldstone, Andrew

    2012-03-01

    Lung imaging, visualization and measurement of alveolar volume has great importance in determining lung health. However, the heterogeneity of lung tissue complicates this task. In this paper multi angle Optical Coherence Tomography (OCT) is used to overcome this problem. One of the limitations of utilizing OCT in lung is the speckle noise and artifacts that originate from the refraction at the tissue-air interface inside the lung. Multi angle view of lung using OCT is incoherent summation of multiple angle-diverse images. Utilizing image registration of multi angle OCT scans of the lung helps reduce the speckle noise and refraction artifacts. This technique helps extract more information from the images which improves visualization and the ability to measure the geometry of alveoli. The other diculty of utilizing OCT is interpreting the images due to the low numerical aperture (NA) on the OCT. The multi angle view of the lung increases NA, which increase the imaging resolution through synthetic aperture imaging. In this paper in ated excised lung tissue and lung phantom are presented.

  5. Reduction of recruitment of Acartia pacifica nauplii from benthic resting eggs due to organochlorine pesticides

    Institute of Scientific and Technical Information of China (English)

    JIANG Xiao-dong; WANG Gui-zhong; LI Shao-jing

    2006-01-01

    Many estuarine and coastal planktonic copepods depend on the hatching of benthic resting eggs for recruitment of nauplii to the water column population. The potential effects of two organochlorine pesticides, hexchloriobinzene (HCH) and dichlorodiphenyltrichloroethane (DDT), on the recruitment of Acartia pacifica nauplii from benthic resting eggs in the seabed of Xiamen Bay were experimentally investigated. The abundance of A. pacifica nauplii hatched from the sediment significantly decreased with the increase of pesticide concentration. Trimmed Spearman-Karber analysis gave sediment 96-h LC50 values were84.81 ng/g for HCH, and 157.94 ng/g for DDT. The median AI (AI50) was -0.77, which suggested that the combined effect of HCH and DDT showed a weak effect than individual effects. There was a positive relationship between mortality and exposure time in DDT treatment, while the relationship was not significant in HCH treatment. The results suggest that organochlorine pesticides can reduce recruitment ofA. pacifica nauplii from benthic resting eggs to planktonic population.

  6. Epidemiological characterization of primary open-angle glaucoma

    Directory of Open Access Journals (Sweden)

    Leonor Rosario Díaz Alfonso

    2010-11-01

    Full Text Available Background: The primary open-angle glaucoma is a problem for public health all over the world. It is a silent and slowly progressive disease leading to blindness. In most patients this can be prevented if the risk factors leading to the disease are detected in time. Objective: To describe some epidemiological factors of patients with primary open-angle glaucoma. Methods: Clinical, epidemiological, prospective and longitudinal study in patients with primary open-angle glaucoma who attended the glaucoma consultation of the Provincial General University Hospital "Dr. Gustavo Aldereguía Lima" of Cienfuegos, from January to February 2009. The following variables were analyzed: age, sex, family and personal medical history, toxic habits and time of diagnosis of the disease. Results: There was prevalence of primary open-angle glaucoma (87, 5% mostly in females (53, 6% and patients over 61 years old as well as in white skinned patients (52 and 62% respectively. Hypertension was the leading entity referred to as pathological personal and family antecedent (62 and 42% respectively. Glaucoma and myopia predominated as previous eye history. The most frequent toxic habits were the consumption of more than 2 cups of coffee a day (53% and smoking (32%. The largest amount of patients had more than 5 years evolution of the disease. Conclusions: Primary open-angle glaucoma occurred mainly in female patients and those with a history

  7. Scattering-angle based filtering of the waveform inversion gradients

    KAUST Repository

    Alkhalifah, Tariq Ali

    2014-11-22

    Full waveform inversion (FWI) requires a hierarchical approach to maneuver the complex non-linearity associated with the problem of velocity update. In anisotropic media, the non-linearity becomes far more complex with the potential trade-off between the multiparameter description of the model. A gradient filter helps us in accessing the parts of the gradient that are suitable to combat the potential non-linearity and parameter trade-off. The filter is based on representing the gradient in the time-lag normalized domain, in which the low scattering angle of the gradient update is initially muted out in the FWI implementation, in what we may refer to as a scattering angle continuation process. The result is a low wavelength update dominated by the transmission part of the update gradient. In this case, even 10 Hz data can produce vertically near-zero wavenumber updates suitable for a background correction of the model. Relaxing the filtering at a later stage in the FWI implementation allows for smaller scattering angles to contribute higher-resolution information to the model. The benefits of the extended domain based filtering of the gradient is not only it\\'s ability in providing low wavenumber gradients guided by the scattering angle, but also in its potential to provide gradients free of unphysical energy that may correspond to unrealistic scattering angles.

  8. CoREST1 promotes tumor formation and tumor stroma interactions in a mouse model of breast cancer.

    Directory of Open Access Journals (Sweden)

    Sohini Mazumdar

    Full Text Available Regulators of chromatin structure and gene expression contribute to tumor formation and progression. The co-repressor CoREST1 regulates the localization and activity of associated histone modifying enzymes including lysine specific demethylase 1 (LSD1 and histone deacetylase 1 (HDAC1. Although several CoREST1 associated proteins have been reported to enhance breast cancer progression, the role of CoREST1 in breast cancer is currently unclear. Here we report that knockdown of CoREST1 in the basal-type breast cancer cell line, MDA-MB-231, led to significantly reduced incidence and diminished size of tumors compared to controls in mouse xenograft studies. Notably, CoREST1-depleted cells gave rise to tumors with a marked decrease in angiogenesis. CoREST1 knockdown led to a decrease in secreted angiogenic and inflammatory factors, and mRNA analysis suggests that CoREST1 promotes expression of genes related to angiogenesis and inflammation including VEGF-A and CCL2. CoREST1 knockdown decreased the ability of MDA-MB-231 conditioned media to promote endothelial cell tube formation and migration. Further, tumors derived from CoREST1-depleted cells had reduced macrophage infiltration and the secretome of CoREST1 knockdown cells was deficient in promoting macrophage migration and macrophage-mediated angiogenesis. Taken together, these findings reveal that the epigenetic regulator CoREST1 promotes tumorigenesis in a breast cancer model at least in part through regulation of gene expression patterns in tumor cells that have profound non-cell autonomous effects on endothelial and inflammatory cells in the tumor microenvironment.

  9. Automated measurement of diagnostic angles for hip dysplasia

    Science.gov (United States)

    de Raedt, Sepp; Mechlenburg, Inger; Stilling, Maiken; Rømer, Lone; Søballe, Kjeld; de Bruijne, Marleen

    2013-03-01

    A fully automatic method for measuring diagnostic angles of hip dysplasia is presented. The method consists of the automatic segmentation of CT images and detection of anatomical landmarks on the femur and acetabulum. The standard angles used in the diagnosis of hip dysplasia are subsequently automatically calculated. Previous work in automating the measuring of angles required the manual segmentation or delineation of the articular joint surface. In the current work automatic segmentation is established using graph-cuts with a cost function based on a sheetness score to detect the sheet-like structure of the bone. Anatomical landmarks are subsequently detected using heuristics based on ray-tracing and the distance to the approximated acetabulur joint surface. Standard diagnositic angles are finally calculated and presented for interpretation. Experiments using 26 patients, showed a good agreement with gold standard manual measurements by an expert radiologist as performed in daily practice. The mean difference for the five angles was between -1:1 and 2:0 degrees with a concordance correlation coefficient between 0:87 and 0:93. The standard deviation varied between 2:3 and 4:1 degrees. These values correspond to values found in evaluating interobserver and intraobserver variation for manual measurements. The method can be used in clinical practice to replace the current manual measurements performed by radiologists. In the future, the method will be integrated into an intraoperative surgical guidance system.

  10. Communicability Angle and the Spatial Efficiency of Networks

    CERN Document Server

    Estrada, Ernesto

    2014-01-01

    We introduce the concept of communicability angle between a pair of nodes in a graph. We provide strong analytical and empirical evidence that the average communicability angle for a given network accounts for its spatial efficiency on the basis of the communications among the nodes in a network. We determine characteristics of the spatial efficiency of more than a hundred real-world complex networks that represent complex systems arising in a diverse set of scenarios. In particular, we find that the communicability angle correlates very well with the experimentally measured the relative packing efficiency of proteins that are represented as residue networks. We finally show how we can modulate the spatial efficiency of a network by tuning the weights of the edges of the networks. This allows us to predict effects of external stresses on the spatial efficiency of a network as well as to design strategies to improve important parameters in real-world complex systems.

  11. Prospective Evaluation of the Optimal Duration of Bed Rest After Vascular Interventions Using a 3-French Introducer Sheath

    International Nuclear Information System (INIS)

    PurposeTo assess optimal bed-rest duration after vascular intervention by way of the common femoral artery using 3F introducer sheaths.Materials and MethodsEligibility criteria for this single-center, prospective study included clinically necessary angiography, no coagulopathy or anticoagulant therapy, no hypersensitivity to contrast medium, age >20 years, and written, informed consent. Enrolled patients were assigned to one of three groups (105/group) with the duration of bed rest deceased sequentially. A sheath was inserted by way of the common femoral artery using the Seldinger technique. The first group (level 1) received 3 h of bed rest after the vascular intervention. If no bleeding or hematomas developed, the next group (level 2) received 2.5 h of bed rest. If still no bleeding or hematomas developed, the final group (level 3) received 2 h of bed rest. If any patient had bleeding or hematomas after bed rest, the study was terminated, and the bed rest of the preceding level was considered the optimal duration.ResultsA total of 105 patients were enrolled at level 1 between November 2010 and September 2011. Eight patients were excluded from analysis because cessation of bed rest was delayed. None of the remaining subjects experienced postoperative bleeding; therefore, patient enrollment at level 2 began in September 2011. However, puncture site bleeding occurred in the 52nd patient immediately after cessation of bed rest, necessitating study termination.ConclusionTo prevent bleeding, at least 3 h of postoperative bed rest is recommended for patients undergoing angiography using 3F sheaths

  12. Prospective Evaluation of the Optimal Duration of Bed Rest After Vascular Interventions Using a 3-French Introducer Sheath

    Energy Technology Data Exchange (ETDEWEB)

    Aramaki, Takeshi, E-mail: t.aramaki@scchr.jp; Moriguchi, Michihisa, E-mail: m.moriguchi@scchr.jp; Bekku, Emima, E-mail: e.bekku@scchr.jp [Shizuoka Cancer Center, Division of Interventional Radiology (Japan); Endo, Masahiro, E-mail: m.endo@scchr.jp; Asakura, Koiku, E-mail: k.asakura@scchr.jp [Shizuoka Cancer Center, Division of Diagnostic Radiology (Japan); Boku, Narikazu, E-mail: n.boku@marianna-u.ac.jp [Shizuoka Cancer Center, Division of Medical Oncology (Japan); Yoshimura, Kenichi, E-mail: keyoshim@med.kobe-u.ac.jp [Kobe University Hospital, Center for Clinical Research (Japan)

    2015-02-15

    PurposeTo assess optimal bed-rest duration after vascular intervention by way of the common femoral artery using 3F introducer sheaths.Materials and MethodsEligibility criteria for this single-center, prospective study included clinically necessary angiography, no coagulopathy or anticoagulant therapy, no hypersensitivity to contrast medium, age >20 years, and written, informed consent. Enrolled patients were assigned to one of three groups (105/group) with the duration of bed rest deceased sequentially. A sheath was inserted by way of the common femoral artery using the Seldinger technique. The first group (level 1) received 3 h of bed rest after the vascular intervention. If no bleeding or hematomas developed, the next group (level 2) received 2.5 h of bed rest. If still no bleeding or hematomas developed, the final group (level 3) received 2 h of bed rest. If any patient had bleeding or hematomas after bed rest, the study was terminated, and the bed rest of the preceding level was considered the optimal duration.ResultsA total of 105 patients were enrolled at level 1 between November 2010 and September 2011. Eight patients were excluded from analysis because cessation of bed rest was delayed. None of the remaining subjects experienced postoperative bleeding; therefore, patient enrollment at level 2 began in September 2011. However, puncture site bleeding occurred in the 52nd patient immediately after cessation of bed rest, necessitating study termination.ConclusionTo prevent bleeding, at least 3 h of postoperative bed rest is recommended for patients undergoing angiography using 3F sheaths.

  13. Influence of the vegetative rests with a different parity C:N on transition Cs 137 from soil in plants

    International Nuclear Information System (INIS)

    On sod-podsolic sandy soil in field experiment with vegetative material (the vegetative rests) and different doses of entering of nitric fertilizers radio caesium accumulation in plants depending on a source of brought nitrogen - nitrogen of fertilizers or nitrogen of the vegetative rests is studied. (authors)

  14. Ultrasound follow up of testicular adrenal rest tumors with congenital adrenal hyperplasia: Report of three cases

    International Nuclear Information System (INIS)

    While testicular adrenal rest tumor is generally a rare intratesticular tumor, it is frequent in patients with congenital adrenal hyperplasia. The tumors are diagnosed and followed up by ultrasound examination because these tumors are non-palpable and symptomless in most cases and always benign. Ultrasound imaging features change depending on how congenital adrenal hyperplasia is controlled. We herein report three cases of testicular adrenal rest tumors with different usual and unusual imaging findings and follow-up imaging. Patient 1 was a 14-year-old boy who presented with poor compliance to medication. Patient 2 and 3 were a 10-year-old and 13-year-old boy who presented with precocious puberty and short stature, respectively. Ultrasound examinations demonstrated oval hypoechoic masses and irregular speculated hyperechoic masses in the testes and different serial imaging findings

  15. Controlled trial of bowel rest and nutritional support in the management of Crohn's disease.

    OpenAIRE

    Greenberg, G R; Fleming, C R; Jeejeebhoy, K N; Rosenberg, I H; Sales, D; Tremaine, W J

    1988-01-01

    To define the role of bowel rest as an independent variable from nutritional support a prospective, randomised controlled trial was undertaken in 51 patients with active Crohn's disease unresponsive to other medical management. Nutritional support for 21 days was randomised to total parenteral nutrition and nil by mouth (n = 17), defined formula diet administered through a nasogastric tube (n = 19), or partial parenteral nutrition and oral food (n = 15). Nutrient input in the first two groups...

  16. Yaw Control At High Angles Of Attack

    Science.gov (United States)

    Murri, Daniel G.; Rao, Dhanvada M.

    1988-01-01

    Hinged, conformal forebody strakes provide control when rudders become ineffective. Device consists of symmetric pair of longitudinally hinged strakes designed to fold completely into forebody contour. Strakes rotate individually out into external flow. Asymmetric flow produced by deployed strake generates sideward force causing aircraft to yaw.

  17. Oscillations of Relative Inclination Angles in Compact Extrasolar Planetary Systems

    CERN Document Server

    Becker, Juliette C

    2015-01-01

    The Kepler Mission has detected dozens of compact planetary systems with more than four transiting planets. This sample provides a collection of close-packed planetary systems with relatively little spread in the inclination angles of the inferred orbits. A large fraction of the observational sample contains limited multiplicity, begging the question whether there is a true diversity of multi transiting systems, or if some systems merely possess high mutual inclinations, allowing them to appear as single-transiting systems in a transit-based survey. This paper begins an exploration of the effectiveness of dynamical mechanisms in exciting orbital inclination within exoplanetary systems of this class. For these tightly packed systems, we determine that the orbital inclination angles are not spread out appreciably through self-excitation. In contrast, the two Kepler multi-planet systems with additional non-transiting planets are susceptible to oscillations of their inclination angles, which means their currently...

  18. Rest life time management of Kozloduy NPPP Unit 3 and 4

    International Nuclear Information System (INIS)

    The radiation life time of reactor pressure vessel (RPV) is the most important limiting factor for the term of exploitation of the whole power unit. The main degradation mechanism of RPV metal is the neutron induced embrittlement. Processes of radiation ageing running in RPV metal lead to fracture toughness decrease and to increased probability of brittle fracture of the vessel under thermal shocks. This explains the importance of RPV integrity assessment and rest life time management

  19. Rotational Angle Measurement of Bridge Support Using Image Processing Techniques

    Directory of Open Access Journals (Sweden)

    Young-Soo Park

    2016-01-01

    Full Text Available Measuring a very small rotational angle accurately and dynamically is indeed a challenging issue, especially in the case of bridge support. Also, existing inclinometers do not have sufficient resolution and accuracy to measure a bridge’s rotational angle. In this study, a new measurement system was developed to provide a practical means for measuring dynamic rotational angle of a bridge support. It features high resolution and accuracy compared with the available systems on the market. By the combinational use of a laser pointer and a vision-based displacement measurement system, the measurement accuracy was significantly increased. The accuracy and applicability were investigated through laboratory tests. From the laboratory tests, it has been found that the developed system can be applicable to bridge support with very small rotational angle. The effectiveness of the developed system was verified through field tests on real bridges. From the full-scale implementation on two PSC girder bridges, it is observed that the proposed system can measure the rotational angle with a high accuracy and reliability.

  20. The optimal angle of Release in Shot Put

    CERN Document Server

    Lenz, Alexander

    2010-01-01

    We determine the optimal angle of release in shot put. The simplest model - mostly used in textbooks - gives a value of $45^\\circ$, while measurements of top athletes cluster around $37 - 38^\\circ$. Including simply the height of the athlete the theory prediction goes down to about $42^\\circ$ for typical parameters of top athletes. Taking further the correlations of the initial velocity of the shot, the angle of release and the height of release into account we predict values around $37 - 38^\\circ$, which coincide perfectly with the measurements.

  1. Angle of Arrival Detection with Fifth Order Phase Operators

    CERN Document Server

    Khmou, Youssef

    2015-01-01

    In this paper, a fifth order propagator operators are proposed for estimating the Angles Of Arrival (AOA) of narrowband electromagnetic waves impinging on antenna array when its number of sensors is larger than the number of radiating sources. The array response matrix is partitioned into five linearly dependent phases to construct the noise projector using five different propagators from non diagonal blocks of the spectral matrice of the received data; hence, five different estimators are proposed to estimate the angles of the sources. The simulation results proved the performance of the proposed estimators in the presence of white noise comparatively to high resolution eigen based spectra.

  2. Topsoil as Affected by Dung Deposition Under Resting Places of Red Howler Monkey (Alouatta seniculus)

    Institute of Scientific and Technical Information of China (English)

    S. POUVELLE; F. FEER; J. F. PONGE

    2008-01-01

    The short-term influence of dung deposition and the further redistribution of dung by dung beetles were studied under a resting place of the red howler monkey (Alouatta senieulus) living in tropical rainforests of South America. Monkey dung was experimentally clumped on the field in a place used by troops of howler monkeys for resting in the Nouragues Reserve Station, French Guiana. Dung-treated plots were sampled serially over three weeks and compared with controls located in their immediate vicinity. The composition of the soil matrix (top 10 cm) was studied in successive microlayers using an optical method. Under the influence of dung beetle activity, the topsoil became more homogeneous by losing its litter, its content in earthworm aeces increased in the course of time, and surface mineral deposits were penetrated by roots. The results were interpreted in the light of present knowledge on the effects of soil animal activity on plant growth and survival of seedlings.

  3. Effect of attack angle on flow characteristic of centrifugal fan

    Science.gov (United States)

    Wu, Y.; Dou, H. S.; Wei, Y. K.; Chen, X. P.; Chen, Y. N.; Cao, W. B.

    2016-05-01

    In this paper, numerical simulation is performed for the performance and internal flow of a centrifugal fan with different operating conditions using steady three-dimensional incompressible Navier-Stokes equations coupled with the RNG k-e turbulent model. The performance curves, the contours of static pressure, total pressure, radial velocity, relative streamlines and turbulence intensity at different attack angles are obtained. The distributions of static pressure and velocity on suction surface and pressure surface in the same impeller channel are compared for various attack angles. The research shows that the efficiency of the centrifugal fan is the highest when the attack angle is 8 degree. The main reason is that the vortex flow in the impeller is reduced, and the jet-wake pattern is weakened at the impeller outlet. The pressure difference between pressure side and suction side is smooth and the amplitude of the total pressure fluctuation is low along the circumferential direction. These phenomena may cause the loss reduced for the attack angle of about 8 degree.

  4. Preliteracy signatures of poor-reading abilities in resting-state EEG

    OpenAIRE

    Giuseppina Schiavone; Maurits, Natasha M.; Maassen, Ben A. M.; Aryan van der Leij

    2014-01-01

    The hereditary character of dyslexia suggests the presence of putative underlying neural anomalies already in preliterate age. Here, we investigated whether early neurophysiological correlates of future reading difficulties—a hallmark of dyslexia—could be identified in the resting-state EEG of preliterate children. The children in this study were recruited at birth and classified on the basis of parents’ performance on reading tests to be at-risk of becoming poor readers (n = 48) or not (n = ...

  5. Preliteracy signatures of poor-reading abilities in resting-state EEG

    OpenAIRE

    Schiavone, Giuseppina; Linkenkaer-Hansen, Klaus; Maurits, Natasha M.; Plakas, Anna; Maassen, Ben A. M.; Mansvelder, Huibert D.; van der Leij, Aryan; van Zuijen, Titia L.

    2014-01-01

    The hereditary character of dyslexia suggests the presence of putative underlying neural anomalies already in preliterate age. Here, we investigated whether early neurophysiological correlates of future reading difficulties—a hallmark of dyslexia—could be identified in the resting-state EEG of preliterate children. The children in this study were recruited at birth and classified on the basis of parents' performance on reading tests to be at-risk of becoming poor readers (n = 48) or not (n = ...

  6. Orientation angle and the adhesion of single gecko setae.

    Science.gov (United States)

    Hill, Ginel C; Soto, Daniel R; Peattie, Anne M; Full, Robert J; Kenny, T W

    2011-07-01

    We investigated the effects of orientation angle on the adhesion of single gecko setae using dual-axis microelectromechanical systems force sensors to simultaneously detect normal and shear force components. Adhesion was highly sensitive to the pitch angle between the substrate and the seta's stalk. Maximum lateral adhesive force was observed with the stalk parallel to the substrate, and adhesion decreased smoothly with increasing pitch. The roll orientation angle only needed to be roughly correct with the spatular tuft of the seta oriented grossly towards the substrate for high adhesion. Also, detailed measurements were made to control for the effect of normal preload forces. Higher normal preload forces caused modest enhancement of the observed lateral adhesive force, provided that adequate contact was made between the seta and the substrate. These results should be useful in the design and manufacture of gecko-inspired synthetic adhesives with anisotropic properties, an area of substantial recent research efforts. PMID:21288955

  7. Experimental investigation of synthetic aperture flow angle estimation

    DEFF Research Database (Denmark)

    Oddershede, Niels; Jensen, Jørgen Arendt

    2005-01-01

    Currently synthetic aperture flow methods can find the correct velocity magnitude, when the flow direction is known. To make a fully automatic system, the direction should also be estimated. Such an approach has been suggested by Jensen (2004) based on a search of the highest cross-correlation as a...... function of velocity and angle. This paper presents an experimental investigation of this velocity angle estimation method based on a set of synthetic aperture flow data measured using our RASMUS experimental ultrasound system. The measurements are performed for flow angles of 60, 75, and 90 deg. with...... respect to the axial direction, and for constant velocities with a peak of 0.1 m/s and 0.2 m/s. The implemented synthetic aperture imaging method uses virtual point sources in front of the transducer, and recursive imaging is used to increase the data rate. A 128 element linear array transducer is used...

  8. Analysis of a Low-Angle Annular Expander Nozzle

    Directory of Open Access Journals (Sweden)

    Kyll Schomberg

    2015-01-01

    Full Text Available An experimental and numerical analysis of a low-angle annular expander nozzle is presented to observe the variance in shock structure within the flow field. A RANS-based axisymmetric numerical model was used to evaluate flow characteristics and the model validated using experimental pressure readings and schlieren images. Results were compared with an equivalent converging-diverging nozzle to determine the capability of the wake region in varying the effective area of a low-angle design. Comparison of schlieren images confirmed that shock closure occurred in the expander nozzle, prohibiting the wake region from affecting the area ratio. The findings show that a low angle of deflection is inherently unable to influence the effective area of an annular supersonic nozzle design.

  9. Infinite Relational Modeling of Functional Connectivity in Resting State fMRI

    OpenAIRE

    Mørup, Morten; Madsen, Kristoffer H.; Dogonowski, Anne Marie; Siebner, Hartwig; Hansen, Lars Kai

    2010-01-01

    Functional magnetic resonance imaging (fMRI) can be applied to study the functional connectivity of the neural elements which form complex network at a whole brain level. Most analyses of functional resting state networks (RSN) have been based on the analysis of correlation between the temporal dynamics of various regions of the brain. While these models can identify coherently behaving groups in terms of correlation they give little insight into how these groups interact. In this paper we ta...

  10. Abnormal cerebral functional connectivity in esophageal cancer patients with theory of mind deficits in resting state

    OpenAIRE

    Yin Cao; JianBo Xiang; Nong Qian; SuPing Sun; LiJun Hu; YongGui Yuan

    2015-01-01

    Objective: To explore the function of the default mode network (DMN) in the psychopathological mechanisms of theory of mind deficits in patients with an esophageal cancer concomitant with depression in resting the state. Subjects and Methods: Twenty-five cases of esophageal cancer with theory of mind deficits (test group) that meet the diagnostic criteria of esophageal cancer and neuropsychological tests, including Beck depression inventory, reading the mind in the eyes, and Faux pas, were...

  11. Ambiguities in the deduction of rest frame fluctuation spectrums from spectrums computed in moving frames

    International Nuclear Information System (INIS)

    The problem of interpretation of power spectrums computed by Fourier analysis of data time series taken in frames moving with respect to the medium containing the fluctuations is examined. It is found that no unique connection exists between the rest frame power spectrum as a function of scale length and the derived power spectrum as a function 'frequency' computed from the time series data taken in the moving frame. This caused by a complex Doppler-shifting phenomenon that leads to a basically aliased frequency spectrum in the moving frame. Examples of nonuniqueness are given for various types of rest frame density or wave turbulence that lead to the same frequency dependence of the power spectrum computed in the moving frame. This has implications for the past interpretations of power spectrums of density or magnetic field fluctuations from satellites or interplanetary probes

  12. Determination of the mixing angle between new charmonium states

    International Nuclear Information System (INIS)

    Using the pictures for X(3872) as a mixture of charmonium and molecular D∗0D0 states; Y(3940) as a mixture of χc0 and D∗D′∗ states, and Y(4260) as a mixture of the tetra-quark state with charmonium states, the corresponding mixing angles are estimated within the QCD sum rules. We find that our predictions for the mixing angles of the X(3872), Y(4260), and Y(3940) states are considerably smaller compared to work in which the mixing angles are estimated from the condition in reproducing the mass of these states. Our conclusion is that the considered pictures for the X(3872), Y(4260), and Y(3940) states are not successful in describing these states

  13. Determination of the mixing angle between new charmonium states

    International Nuclear Information System (INIS)

    Using the pictures for X(3872) as a mixture of charmonium and molecular D*0D0 states; Y(3940) as a mixture of χc0 and D*D'* states, and Y(4260) as a mixture of the tetra-quark state with charmonium states, the corresponding mixing angles are estimated within the QCD sum rules. We find that our predictions for the mixing angles of the X(3872), Y(4260), and Y(3940) states are considerably smaller compared to work in which the mixing angles are estimated from the condition in reproducing the mass of these states. Our conclusion is that the considered pictures for the X(3872), Y(4260), and Y(3940) states are not successful in describing these states. (orig.)

  14. LONG-TERM MEASUREMENTS OF SUNSPOT MAGNETIC TILT ANGLES

    Energy Technology Data Exchange (ETDEWEB)

    Li Jing [Department of Earth and Space Sciences, University of California at Los Angeles, Los Angeles, CA 90095-1567 (United States); Ulrich, Roger K., E-mail: jli@igpp.ucla.edu [Department of Physics and Astronomy, University of California at Los Angeles, Los Angeles, CA 90095-1567 (United States)

    2012-10-20

    Tilt angles of close to 30,600 sunspots are determined using Mount Wilson daily averaged magnetograms taken from 1974 to 2012, and SOHO/MDI magnetograms taken from 1996 to 2010. Within a cycle, more than 90% of sunspots have a normal polarity alignment along the east-west direction following Hale's law. The median tilts increase with increasing latitude (Joy's law) at a rate of {approx}0.{sup 0}5 per degree of latitude. Tilt angles of spots appear largely invariant with respect to time at a given latitude, but they decrease by {approx}0.{sup 0}9 per year on average, a trend that largely reflects Joy's law following the butterfly diagram. We find an asymmetry between the hemispheres in the mean tilt angles. On average, the tilts are greater in the Southern than in the Northern Hemisphere for all latitude zones, and the differences increase with increasing latitude.

  15. LONG-TERM MEASUREMENTS OF SUNSPOT MAGNETIC TILT ANGLES

    International Nuclear Information System (INIS)

    Tilt angles of close to 30,600 sunspots are determined using Mount Wilson daily averaged magnetograms taken from 1974 to 2012, and SOHO/MDI magnetograms taken from 1996 to 2010. Within a cycle, more than 90% of sunspots have a normal polarity alignment along the east-west direction following Hale's law. The median tilts increase with increasing latitude (Joy's law) at a rate of ∼0.05 per degree of latitude. Tilt angles of spots appear largely invariant with respect to time at a given latitude, but they decrease by ∼0.09 per year on average, a trend that largely reflects Joy's law following the butterfly diagram. We find an asymmetry between the hemispheres in the mean tilt angles. On average, the tilts are greater in the Southern than in the Northern Hemisphere for all latitude zones, and the differences increase with increasing latitude.

  16. Long-Term Measurements of Sunspot Magnetic Tilt Angles

    CERN Document Server

    Li, Jing

    2012-01-01

    Tilt angles of close to 30,600 sunspots are determined using Mount Wilson daily averaged magnetograms taken from 1974 to 2012, and MDI/SoHO magnetograms taken from 1996 to 2010. Within a cycle, more than 90% of sunspots have a normal polarity alignment along the east-west direction following Hale's law. The median tilts increase with increasing latitude (Joy's law) at a rate of ~0.5 degree per degree of latitude. Tilt angles of spots appear largely invariant with respect to time at a given latitude, but they decrease by ~0.9degree per year on average, a trend which largely reflects Joy's law following the butterfly diagram. We find an asymmetry between the hemispheres in the mean tilt angles. On average, the tilts are greater in the southern than in the northern hemisphere for all latitude zones, and the differences increase with increasing latitude.

  17. Determination of the mixing angle between new charmonium states

    Energy Technology Data Exchange (ETDEWEB)

    Aliev, T.M. [Middle East Technical University, Physics Department, Ankara (Turkey); Institute of Physics, Baku (Azerbaijan); Savci, M. [Middle East Technical University, Physics Department, Ankara (Turkey)

    2015-04-01

    Using the pictures for X(3872) as a mixture of charmonium and molecular D{sup *0}D{sup 0} states; Y(3940) as a mixture of χ{sub c0} and D{sup *}D{sup '*} states, and Y(4260) as a mixture of the tetra-quark state with charmonium states, the corresponding mixing angles are estimated within the QCD sum rules. We find that our predictions for the mixing angles of the X(3872), Y(4260), and Y(3940) states are considerably smaller compared to work in which the mixing angles are estimated from the condition in reproducing the mass of these states. Our conclusion is that the considered pictures for the X(3872), Y(4260), and Y(3940) states are not successful in describing these states. (orig.)

  18. Determination of the mixing angle between new charmonium states

    Energy Technology Data Exchange (ETDEWEB)

    Aliev, T. M., E-mail: taliev@metu.edu.tr [Physics Department, Middle East Technical University, 06800, Ankara (Turkey); Institute of Physics, Baku (Azerbaijan); Savcı, M., E-mail: savci@metu.edu.tr [Physics Department, Middle East Technical University, 06800, Ankara (Turkey)

    2015-04-28

    Using the pictures for X(3872) as a mixture of charmonium and molecular D{sup ∗0}D{sup 0} states; Y(3940) as a mixture of χ{sub c0} and D{sup ∗}D{sup ′∗} states, and Y(4260) as a mixture of the tetra-quark state with charmonium states, the corresponding mixing angles are estimated within the QCD sum rules. We find that our predictions for the mixing angles of the X(3872), Y(4260), and Y(3940) states are considerably smaller compared to work in which the mixing angles are estimated from the condition in reproducing the mass of these states. Our conclusion is that the considered pictures for the X(3872), Y(4260), and Y(3940) states are not successful in describing these states.

  19. Effect of external pressure on intramuscular blood flow at rest and after running

    International Nuclear Information System (INIS)

    Local blood flow in the thigh was measured with 133Xe clearance technique in eight male distance runners after compression with a foam rubber compress and a standard elastic bandage. Two degrees of compression were tested, and an initial experiment with rested subjects was followed by a similar experiment immediately after running. Maximum compression exerted a cutaneous pressure of 85 (+/- 8) mm Hg and caused an immediate cessation of intra-muscular blood flow in the compressed area. Moderate compression gave a cutaneous pressure of 40 (+/- 5) mm Hg and resulted in a reduction of blood flow by approximately 50%. During compression, there were no significant differences in the blood flow of rested subjects compared to subjects immediately after running. In acute soft tissue injuries, a maximum compression bandage should effectively reduce or eliminate the formation of an intra-muscular hematoma, and an additive effect on blood flow of ice should not be expected

  20. BIPHASIC TREATMENT OF 2ND CLASS ANGLE ANOMALIES

    Directory of Open Access Journals (Sweden)

    C. Romanec

    2011-09-01

    Full Text Available Our approach aims at presenting, based on clinical observations and complementary examinations, the effects of a treatment’s setting up during the mixed dentition period. The objectives include the identification of the optimal time of treatment of II/1, II/2 Angle malocclusions, as well as the therapeutic possibilities for the treatment of 2nd class Angle malocclusion during the period of mixed and permanent dentition. The study is based on data collected from 114 clinical cases (69 girls and 45 boys with an age span between 7 and 18 years.

  1. Angle dependence of Andreev scattering at semiconductor-superconductor interfaces

    DEFF Research Database (Denmark)

    Mortensen, Asger; Flensberg, Karsten; Jauho, Antti-Pekka

    1999-01-01

    We study the angle dependence of the Andreev scattering at a semiconductor-superconductor interface, generalizing the one-dimensional theory of Blonder, Tinkham, and Klapwijk (BTK),An increase of the momentum parallel to the interface leads to suppression of the probability of Andreev reflection ...... angle of incidence above which only normal reflection exists. For two- and three-dimensional interfaces a lower excess current compared to ballistic transport with perpendicular incidence is found. Thus, the one-dimensional BTK model overestimates the barrier strength for two- and three...

  2. RELATIONSHIP BETWEEN THE SIZE OF PONTOCEREBELLAR ANGLE TUMOR AND AUDIOLOGY

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Objective: To study the relationship between the size ofpontocerebellar angle tumor and audiology.Methods: Retrospective analysis of accoustically evoked brainstem response (ABR) waveforms and pure tone threshold in 27 subjects with tumor of pontocerebellar angle.Results: ABR wave forms and pure tone threshold were significantly affected statistically by the size of tumors,especially those tumor larger than 3 cm in diameter.Conclusion: The primary symptom of the patient was unilateral hearing loss.Early discovery of the lesion is important and ABR is a sensitive tool for early diagnose of the tumor.

  3. Structure and Inclination Angle of the Spiral Galaxy M31

    Institute of Scientific and Technical Information of China (English)

    MA Jun

    2001-01-01

    The mathematical form, the symmetry of the spiral structure, and the projection of the galactic disc on the image of the spiral galaxy M31 have been directly studied. It is found that M31 has two symmetric arms, i.e. the pitch angles of the two arms are nearly equal; these are 7.7° and 8.0°, respectively. Using the method proposed in this letter, the inclination angle of the galactic disc ofM31 is also obtained, which is 77.5° and is in good agreement with previously published results.

  4. Analysis and design of wide-angle foveated optical systems

    Science.gov (United States)

    Curatu, George

    2009-12-01

    The development of compact imaging systems capable of transmitting high-resolution images in real-time while covering a wide field-of-view (FOV) is critical in a variety of military and civilian applications: surveillance, threat detection, target acquisition, tracking, remote operation of unmanned vehicles, etc. Recently, optical foveated imaging using liquid crystal (LC) spatial light modulators (SLM) has received considerable attention as a potential approach to reducing size and complexity in fast wide-angle lenses. The fundamental concept behind optical foveated imaging is reducing the number of elements in a fast wide-angle lens by placing a phase SLM at the pupil stop to dynamically compensate aberrations left uncorrected by the optical design. In the recent years, considerable research and development has been conducted in the field of optical foveated imaging based on the LC SLM technology, and several foveated optical systems (FOS) prototypes have been built. However, most research has been focused so far on the experimental demonstration of the basic concept using off-the-shelf components, without much concern for the practicality or the optical performance of the systems. Published results quantify only the aberration correction capabilities of the FOS, often claiming diffraction-limited performance at the region of interest (ROI). However, these results have continually overlooked diffraction effects on the zero-order efficiency and the image quality. The research work presented in this dissertation covers the methods and results of a detailed theoretical research study on the diffraction analysis, image quality, design, and optimization of fast wide-angle FOSs based on the current transmissive LC SLM technology. The amplitude and phase diffraction effects caused by the pixelated aperture of the SLM are explained and quantified, revealing fundamental limitations imposed by the current transmissive LC SLM technology. As a part of this study, five

  5. Rest improves performance, nature improves happiness: Assessment of break periods on the abbreviated vigilance task.

    Science.gov (United States)

    Finkbeiner, Kristin M; Russell, Paul N; Helton, William S

    2016-05-01

    The abbreviated vigilance task can quickly generate vigilance decrements, which has been argued is due to depletion of cognitive resources needed to sustain performance. Researchers suggest inclusion of rest breaks within vigilance tasks improve overall performance (Helton & Russell, 2015; Ross, Russell, & Helton, 2014), while different types of breaks demonstrate different effects. Some literature suggests exposure to natural movements/stimuli helps restore attention (Herzog, Black, Fountaine, & Knotts, 1997; Kaplan, 1995). Participants were randomly assigned to one experimental condition: dog video breaks, robot video breaks, countdown breaks or continuous vigilance. We assessed task performance and subjective reports of stress/workload. The continuous group displayed worst performance, suggesting breaks help restore attention. The dog videos did not affect performance, however, decreased reports of distress. These results support the importance of rest breaks and acknowledge the benefit of natural stimuli for promoting wellbeing/stress relief, overall suggesting performance and wellbeing may be independent, which warrants future studies. PMID:27089530

  6. Changes in distribution of lung perfusion and ventilation at rest and during maximal exercise

    International Nuclear Information System (INIS)

    A new method for evaluation of changes in the distribution of pulmonary perfusion and ventilation during exercise was applied to normal male volunteers. Ventilation and perfusion scans were done with the subjects seated on a bicycle ergometer. The resting studies utilized krypton 81 (/sup 81m/Kr) for ventilation and technetium /sup 99m/ (/sup 99m/Tc) macroaggregate albumin intravenously for perfusion. Exercise studies were done when 80 percent of maximum predicted heart rate was maintained for five minutes and utilized /sup 81m/Kr for ventilation and a tenfold dose of /sup 99m/Tc for perfusion. Higher dose of /sup 99m/Tc would minimize the effect of radioactivity left over from the resting study. This method allowed us to assess changes in ventilation and perfusion in normal subjects induced by exercise, but may also be applicable in a variety of cardiopulmonary conditions that affect pulmonary ventilation and perfusion or both

  7. Evolution of the Jet Opening Angle Distribution in Holographic Plasma.

    Science.gov (United States)

    Rajagopal, Krishna; Sadofyev, Andrey V; van der Schee, Wilke

    2016-05-27

    We use holography to analyze the evolution of an ensemble of jets, with an initial probability distribution for their energy and opening angle as in proton-proton (pp) collisions, as they propagate through an expanding cooling droplet of strongly coupled plasma as in heavy ion collisions. We identify two competing effects: (i) each individual jet widens as it propagates and (ii) because wide-angle jets lose more energy, energy loss combined with the steeply falling perturbative spectrum serves to filter wide jets out of the ensemble at any given energy. Even though every jet widens, jets with a given energy can have a smaller mean opening angle after passage through the plasma than jets with that energy would have had in vacuum, as experimental data may indicate. PMID:27284647

  8. Contact angles of drops on curved superhydrophobic surfaces.

    Science.gov (United States)

    Viswanadam, Goutham; Chase, George G

    2012-02-01

    Superhydrophobic surfaces have contact angles that exceed 150 degrees and are known to reduce surface fouling, protect surfaces, and improve liquid-liquid separations. Electrospun sub-micron fiber mats can perform as superhydrophobic surfaces. Superhydrophobic behavior is typically measured on planar surfaces, whereas applications may require curved surfaces. This paper discuses the measurement of water contact angles of fiber mats formed on cylindrical surfaces to create superhydrophobic behavior on curved surfaces. Equations are derived that relate the radius of curvature of spherical and cylindrical surfaces and drop size to the observed contact angle on the curved surfaces. Calculations from the equations agree well with experimental observations on spherical surfaces reported in literature and on cylindrical surfaces created in our lab. PMID:22129634

  9. Measurement of the CKM angle $\\gamma$ at LHCb

    CERN Multimedia

    Gersabeck, M

    2009-01-01

    The precise measurement of the CKM unitarity triangle angle $\\gamma$ is a key goal of the LHCb physics programme. The uncertainty on $\\gamma$, the currently least-well known of the three angles, will be reduced dramatically. Complementary measurements will be made in tree-level processes, and modes where loop diagrams play an important role. The tree-level measurements will cover time-integrated as well as time- dependent measurements in both the $B^0_d$ and the $B^0_s$ sectors. The ensemble of these measurements will provide a powerful test of whether new physics phases contribute to heavy-flavour transitions.

  10. Long-Term Measurements of Sunspot Magnetic Tilt Angles

    OpenAIRE

    Li, Jing; Ulrich, Roger K.

    2012-01-01

    Tilt angles of close to 30,600 sunspots are determined using Mount Wilson daily averaged magnetograms taken from 1974 to 2012, and MDI/SoHO magnetograms taken from 1996 to 2010. Within a cycle, more than 90% of sunspots have a normal polarity alignment along the east-west direction following Hale's law. The median tilts increase with increasing latitude (Joy's law) at a rate of ~0.5 degree per degree of latitude. Tilt angles of spots appear largely invariant with respect to time at a given la...

  11. Reproducibility of resting state spinal cord networks in healthy volunteers at 7 Tesla.

    Science.gov (United States)

    Barry, Robert L; Rogers, Baxter P; Conrad, Benjamin N; Smith, Seth A; Gore, John C

    2016-06-01

    We recently reported our findings of resting state functional connectivity in the human spinal cord: in a cohort of healthy volunteers we observed robust functional connectivity between left and right ventral (motor) horns and between left and right dorsal (sensory) horns (Barry et al., 2014). Building upon these results, we now quantify the within-subject reproducibility of bilateral motor and sensory networks (intraclass correlation coefficient=0.54-0.56) and explore the impact of including frequencies up to 0.13Hz. Our results suggest that frequencies above 0.08Hz may enhance the detectability of these resting state networks, which would be beneficial for practical studies of spinal cord functional connectivity. PMID:26924285

  12. The influence of biofeedback training on trapezius activity and rest during occupational computer work

    DEFF Research Database (Denmark)

    Holtermann, A; Søgaard, K; Christensen, H; Dahl, B; Blangsted, A

    2008-01-01

    The aim of this study was to investigate effects of biofeedback training on trapezius activity and rest (gaps) during occupational computer work. A randomized controlled trial with 164 computer workers was performed. Two groups working with computer mouse more than 50% (n = 64) and less than 25% (n...... = 49) of their work time performed five sessions with unilateral electromyographical (EMG) biofeedback from the dominant trapezius during computer work. A third group working with computer mouse more than 50% of their work time (n = 51) served as controls. Bipolar EMG from the bilateral upper trapezius...... muscles during normal computer work was recorded. Changes in discomfort/pain were not recorded. The biofeedback training reduced activity (P < 0.05), and increased the frequency of short (P < 0.05) and long (P < 0.05) gaps, and the relative rest time (P < 0.05) of the trapezius during computer work. By...

  13. Discrimination and characterization of Parkinsonian rest tremors by analyzing long-term correlations and multifractal signatures

    CERN Document Server

    Livi, Lorenzo

    2015-01-01

    In this paper, we analyze 48 signals of rest tremor velocity related to 12 distinct subjects affected by Parkinson's disease. The subjects belong to two different groups, formed by four and eight subjects with, respectively, high- and low-amplitude rest tremors. Each subject is tested in four settings, given by combining the use of deep brain stimulation and L-DOPA medication. We develop two main feature-based representations of such signals, which are obtained by considering (i) the long-term correlations and multifractal properties, and (ii) the power spectra. The feature-based representations are initially utilized for the purpose of characterizing the subjects under different settings. In agreement with previous studies, we show that deep brain stimulation does not significantly characterize neither of the two groups, regardless of the adopted representation. On the other hand, the medication effect yields statistically significant differences in both high- and low-amplitude tremor groups. We successively...

  14. Neuroticism and Functional Connectomics of the Resting Adolescent Brain - Insights from a Danish Child Cohort

    DEFF Research Database (Denmark)

    Baruël Johansen, Louise

    The personality trait neuroticism is a well-known risk factor for anxiety and mood disorders that typically have their onset in childhood and adolescence. This period is characterized by ongoing structural and functional maturation of the brain, which can be traced with magnetic resonance imaging...... (MRI). Resting-state functional MRI is a widely used technique for studies of brain development due to the task-free condition. Furthermore, this imaging modality can be used to study the functional network of the brain that subserves communication between regions of the brain. Properties of this...... network can be quantified with graph theory. By using this analytical approach one can assess e.g. how efficiently information is exchanged throughout the brain. Functional network analyses of the adult brain at rest suggest that higher neuroticism scores are associated with a less efficient functional...

  15. Resting-state qEEG predicts rate of second language learning in adults.

    Science.gov (United States)

    Prat, Chantel S; Yamasaki, Brianna L; Kluender, Reina A; Stocco, Andrea

    2016-01-01

    Understanding the neurobiological basis of individual differences in second language acquisition (SLA) is important for research on bilingualism, learning, and neural plasticity. The current study used quantitative electroencephalography (qEEG) to predict SLA in college-aged individuals. Baseline, eyes-closed resting-state qEEG was used to predict language learning rate during eight weeks of French exposure using an immersive, virtual scenario software. Individual qEEG indices predicted up to 60% of the variability in SLA, whereas behavioral indices of fluid intelligence, executive functioning, and working-memory capacity were not correlated with learning rate. Specifically, power in beta and low-gamma frequency ranges over right temporoparietal regions were strongly positively correlated with SLA. These results highlight the utility of resting-state EEG for studying the neurobiological basis of SLA in a relatively construct-free, paradigm-independent manner. PMID:27164483

  16. EFFECT OF 15 DAYS ADVENTURE SPORTS PROGRAMME ON VITAL CAPACITY AND RESTING PULSE RATE

    OpenAIRE

    Sumit Kr Thapa

    2016-01-01

    The main purpose of this study was to determine the effect of Adventure Sports Programme on vital capacity and resting pulse rate. Total thirteen (N=13) subjects were taken from Bachelor of physical education students of Dibrugarh University with ages ranging between 20 to 25 years. The training programme was organised by Dibrugarh University in collaboration with Manipur Mountaineering & Trekking Association, Manipur at Lamdan, Manipur, India at 1250 metre height above sea level. For the...

  17. Alterations of Resting State Functional Connectivity in the Default Network in Adolescents with Autism Spectrum Disorders

    OpenAIRE

    Weng, Shih-Jen; Wiggins, Jillian Lee; Peltier, Scott J.; Carrasco, Melisa; Risi, Susan; Lord, Catherine; Monk, Christopher S.

    2009-01-01

    Autism spectrum disorders (ASD) are associated with disturbances of neural connectivity. Functional connectivity between neural structures is typically examined within the context of a cognitive task, but also exists in the absence of a task (i.e., “rest”). Connectivity during rest is particularly active in a set of structures called the default network, which includes the posterior cingulate cortex (PCC), retrosplenial cortex, lateral parietal cortex/angular gyrus, medial prefrontal cortex, ...

  18. Systematic reviews of bed rest and advice to stay active for acute low back pain.

    OpenAIRE

    Waddell, G; Feder, G; Lewis, M.

    1997-01-01

    BACKGROUND: In the United Kingdom (UK), 9% of adults consult their doctor annually with back pain. The treatment recommendations are based on orthopaedic teaching, but the current management is causing increasing dissatisfaction. Many general practitioners (GPs) are confused about what constitutes effective advice. AIM: To review all randomized controlled trials of bed rest and of medical advice to stay active for acute back pain. METHOD: A systematic review based on a search of MEDLINE and E...

  19. Exercise training reduces resting heart rate via downregulation of the funny channel HCN4

    OpenAIRE

    D'Sousa, Alicia; Bucchi, Annalisa; Johnsen, Anne Berit; Logantha, Sunil; Monfredi, Oliver; Yanni, Joseph; Prehar, Sukhal; Hart, George; Cartwright, Elisabeth; Wisløff, Ulrik; Dobryznski, Halina; DiFrancesco, Dario; Morris, Gwilym; Boyett, Mark

    2014-01-01

    Endurance athletes exhibit sinus bradycardia, that is a slow resting heart rate, associated with a higher incidence of sinus node (pacemaker) disease and electronic pacemaker implantation. Here we show that training-induced bradycardia is not a consequence of changes in the activity of the autonomic nervous system but is caused by intrinsic electrophysiological changes in the sinus node. We demonstrate that training-induced bradycardia persists after blockade of the autonomous nervous system ...

  20. Contact Angles and Surface Tension of Germanium-Silicon Melts

    Science.gov (United States)

    Croell, A.; Kaiser, N.; Cobb, S.; Szofran, F. R.; Volz, M.; Rose, M. Franklin (Technical Monitor)

    2001-01-01

    Precise knowledge of material parameters is more and more important for improving crystal growth processes. Two important parameters are the contact (wetting) angle and the surface tension, determining meniscus shapes and surface-tension driven flows in a variety of methods (Czochralski, EFG, floating-zone, detached Bridgman growth). The sessile drop technique allows the measurement of both parameters simultaneously and has been used to measure the contact angles and the surface tension of Ge(1-x)Si(x) (0 less than or equal to x less than or equal to 1.3) alloys on various substrate materials. Fused quartz, Sapphire, glassy carbon, graphite, SiC, carbon-based aerogel, pyrolytic boron nitride (pBN), AIN, Si3N4, and polycrystalline CVD diamond were used as substrate materials. In addition, the effect of different cleaning procedures and surface treatments on the wetting behavior were investigated. Measurements were performed both under dynamic vacuum and gas atmospheres (argon or forming gas), with temperatures up to 1100 C. In some experiments, the sample was processed for longer times, up to a week, to investigate any changes of the contact angle and/or surface tension due to slow reactions with the substrate. For pure Ge, stable contact angles were found for carbon-based substrates and for pBN, for Ge(1-x)Si(x) only for pBN. The highest wetting angles were found for pBN substrates with angles around 170deg. For the surface tension of Ge, the most reliable values resulted in gamma(T) = (591- 0.077 (T-T(sub m)) 10(exp -3)N/m. The temperature dependence of the surface tension showed similar values for Ge(1-x)Si(x), around -0.08 x 10(exp -3)N/m K, and a compositional dependence of 2.2 x 10(exp -3)N/m at%Si.

  1. Adenosine concentrations in the interstitium of resting and contracting human skeletal muscle

    DEFF Research Database (Denmark)

    Hellsten, Ylva; Maclean, D.; Rådegran, G.;

    1998-01-01

    effect remain unanswered. METHODS AND RESULTS: The interstitial adenosine concentration was determined in the vastus lateralis muscle of healthy humans via dialysis probes inserted in the muscle. The probes were perfused with buffer, and the dialysate samples were collected at rest and during graded knee...... extensor exercise. At rest, the interstitial concentration of adenosine was 220+/-100 nmol/L and femoral arterial blood flow (FaBF) was 0.19+/-0.02 L/min. When the subjects exercised lightly, at a work rate of 10 W, there was a markedly higher (1140+/-540 nmol/L; P... and demonstrates that adenosine and its precursors increase in the exercising muscle interstitium, at a rate associated with intensity of muscle contraction and the magnitude of muscle blood flow....

  2. Regulation of PDH in human arm and leg muscles at rest and during intense exercise

    DEFF Research Database (Denmark)

    Kiilerich, Kristian; Birk, Jesper Bratz; Damsgaard, Rasmus;

    2008-01-01

    To test the hypothesis that pyruvate dehydrogenase (PDH) is differentially regulated in specific human muscles, regulation of PDH was examined in triceps, deltoid, and vastus lateralis at rest and during intense exercise. To elicit considerable glycogen use, subjects performed 30 min of exhaustive...... arm cycling on two occasions and leg cycling exercise on a third day. Muscle biopsies were obtained from deltoid or triceps on the arm exercise days and from vastus lateralis on the leg cycling day. Resting PDH protein content and phosphorylation on PDH-E1 alpha sites 1 and 2 were higher (P < or = 0...... activity of the active form of PDH (PDHa) after 10 min of exercise was more marked in vastus lateralis ( approximately 246%) than in triceps ( approximately 160%), but when it was related to total PDH-E1 alpha protein content, no difference was evident. In conclusion, PDH protein content seems to be...

  3. SLEEPING AND RESTING BEHAVIOR, FACTORS AND IMPLICATIONS IN BREEDING TECHNOLOGY OF CHINCHILLA

    Directory of Open Access Journals (Sweden)

    M. BOTHA

    2013-12-01

    Full Text Available Fallowing many papers, related to different breeding systems of the Chinchilla l., wirenetting floor and bedding cage, which results that there are no significant differencesoverview the growth indices and implicit the forage intake, we where studied thebreed’s behavior to explain all these. Adopting one of the breeding systems involvessmaller or bigger investment, this being the principal aim of this paper. Knowing thatChinchilla has an inactive period of 71,02% from 24 h, they are resting 54,05% and16,97% so-called sleeping in 24 h. From our studies results that most of inactive time(rest and sleeping they are sitting on the dust bath tray, no matter the floor type. Thatexplains there are no significant differences in outputs depending on the adoptedtechnology.

  4. Demonstration of angle-dependent Casimir force between corrugations.

    Science.gov (United States)

    Banishev, A A; Wagner, J; Emig, T; Zandi, R; Mohideen, U

    2013-06-21

    The normal Casimir force between a sinusoidally corrugated gold coated plate and a sphere was measured at various angles between the corrugations using an atomic force microscope. A strong dependence on the orientation angle of the corrugation is found. The measured forces were found to deviate from the proximity force approximation and are in agreement with the theory based on the gradient expansion including correlation effects of geometry and material properties. We analyze the role of temperature. The obtained results open new opportunities for control of the Casimir effect in micromechanical systems. PMID:23829717

  5. Proliferation of epithelial rests of Malassez following auto-transplantation of third molars: a case report

    Directory of Open Access Journals (Sweden)

    Schepers Serge

    2010-10-01

    Full Text Available Abstract Introduction Auto-transplantation of third molars is frequently undertaken in order to restore a perfect occlusion and to improve mastication following a substantial loss of molars. However, little is known about the precise role of the periodontal membrane during this procedure. Therefore, we investigated if the epithelial rests of Malassez persist in the periodontal ligament of auto-transplanted teeth and, if so, whether these may show signs of a neuro-epithelial relationship. Case presentation We report a case of a 21-year-old Caucasian woman who underwent an auto-transplantation of two third molars. After two years, renewed progressive caries of the auto-transplanted teeth led to the removal of the auto-transplanted elements. The periodontal ligament was removed and studied with a light and transmission electron microscope. Conclusion In this report we examined the ultrastructure of the periodontal ligament after auto-transplantation in order to see if the periodontal ligament recovers completely from this intervention. We observed fully developed blood vessels and a re-innervation of the epithelial rests of Malassez which were proliferating following auto-transplantation. This proliferation might be critical in the remodelling of the alveolar socket in order to provide a perfect fit for the transplanted tooth. In order to minimalise the damage to the epithelial rests of Malassez, the extraction of the tooth should be as atraumatic as possible in order to provide an optimal conservation of the periodontal ligament which will be beneficial to the healing-process.

  6. Long-term survival of hydrated resting eggs from Brachionus plicatilis.

    Directory of Open Access Journals (Sweden)

    Melody S Clark

    Full Text Available BACKGROUND: Several organisms display dormancy and developmental arrest at embryonic stages. Long-term survival in the dormant form is usually associated with desiccation, orthodox plant seeds and Artemia cysts being well documented examples. Several aquatic invertebrates display dormancy during embryonic development and survive for tens or even hundreds of years in a hydrated form, raising the question of whether survival in the non-desiccated form of embryonic development depends on pathways similar to those occurring in desiccation tolerant forms. METHODOLOGY/PRINCIPAL FINDINGS: To address this question, Illumina short read sequencing was used to generate transcription profiles from the resting and amictic eggs of an aquatic invertebrate, the rotifer, Brachionus plicatilis. These two types of egg have very different life histories, with the dormant or diapausing resting eggs, the result of the sexual cycle and amictic eggs, the non-dormant products of the asexual cycle. Significant transcriptional differences were found between the two types of egg, with amictic eggs rich in genes involved in the morphological development into a juvenile rotifer. In contrast, representatives of classical "stress" proteins: a small heat shock protein, ferritin and Late Embryogenesis Abundant (LEA proteins were identified in resting eggs. More importantly however, was the identification of transcripts for messenger ribonucleoprotein particles which stabilise RNA. These inhibit translation and provide a valuable source of useful RNAs which can be rapidly activated on the exit from dormancy. Apoptotic genes were also present. Although apoptosis is inconsistent with maintenance of prolonged dormancy, an altered apoptotic pathway has been proposed for Artemia, and this may be the case with the rotifer. CONCLUSIONS: These data represent the first transcriptional profiling of molecular processes associated with dormancy in a non-desiccated form and indicate important

  7. An automated method for identifying artifact in ICA of resting-state fMRI

    Directory of Open Access Journals (Sweden)

    Kaushik eBhaganagarapu

    2013-07-01

    Full Text Available An enduring issue with data-driven analysis and filtering methods is the interpretation of results. To assist, we present an automatic method for identifaction of artifact in independent components (ICs derived from functional MRI (fMRI. The method was designed with the following features: Does not require temporal information about an fMRI paradigm; Does not require the user to train the algorithm; Requires only the fMRI images (additional acquisition of anatomical imaging not required; Is able to identify a high proportion of artifact-related ICs without removing components that are likely to be of neuronal origin; Can be applied to resting-state fMRI; Is automated, requiring minimal or no human intervention.We applied the method to a MELODIC probabilistic ICA of resting-state functional connectivity data acquired in 50 healthy control subjects, and compared the results to a blinded expert manual classification. The method identified between 26% and 72% of the components as artifact (mean 55%. 0.3% of components identified as artifact were discordant with the manual classification; retrospective examination of these ICs suggested the automated method had correctly identified these as artifact.We have developed an effective automated method which removes a substantial number of unwanted noisy components in ICA analyses of resting-state fMRI data. Source code of our implementation of the method is available.

  8. Optimization of sharp and viewing-angle-independent structural color

    CERN Document Server

    Hsu, Chia Wei; Johnson, Steven G; Soljačić, Marin

    2014-01-01

    Structural coloration produces some of the most brilliant colors in nature and has many applications. However, sharp color (narrow frequency response) and wide viewing angle (broad angular response) are competing properties and have not been achieved simultaneously in previous studies. Here, we use numerical optimization to discover geometries where the structural color is sharp, yet the hue, saturation, and brightness all remain the same over broad viewing angles (0-90$^\\circ$) under directional illumination. Our model system consists of dipole scatterers arranged into several rings; interference among the scattered waves is optimized to yield the wavelength-selective and angle-insensitive response. Such designs can be useful for display, painting, and biosensing applications.

  9. Phytoseiid mites (Acari, Mesostigmata) from the rest areas of Hungarian highways

    OpenAIRE

    Kontschán, Jenő; Karap, Anita; Kiss, Balázs

    2014-01-01

    The mesostigmatid mite family Phytoseiidae was surveyed in rest areas of Hungarian highways by examination of leaves collected from arboreal plants. All together 15 species, ca. 20 % of the Hungarian Phytoseiid fauna were recorded. Seven species were collected from the ring highway around Budapest (M0), ten species were found alongside the northwestern highway (M1), six-six species were recorded from the north-eastern and south-eastern highways (M3 and M5), and five species from t...

  10. Effects of capsinoid ingestion on energy expenditure and lipid oxidation at rest and during exercise

    OpenAIRE

    Staples Aaron W; Andrews Richard; Holwerda Andrew M; Sherriffs Scott S; Josse Andrea R; Phillips Stuart M

    2010-01-01

    Abstract Background The thermogenic and metabolic properties of capsinoids appear to mimic those of the more pungent sister compound capsaicin. However, few data exist on how capsinoid ingestion affects energy expenditure in humans and no data exist on its interaction with exercise. We aimed to determine how ingestion of capsinoids affected energy expenditure, lipid oxidation and blood metabolites at rest and during moderate intensity exercise. Methods Twelve healthy young men (age = 24.3 ± 3...

  11. Intensity of Resistance Exercise Determines Adipokine and Resting Energy Expenditure Responses in Overweight Elderly Individuals

    OpenAIRE

    Fatouros, Ioannis G.; Chatzinikolaou, Athanasios; Tournis, Symeon; Michalis G. Nikolaidis; Jamurtas, Athanasios Z.; Douroudos, Ioannis I.; Papassotiriou, Ioannis; Thomakos, Petros M.; Taxildaris, Kyriakos; Mastorakos, George; Mitrakou, Asimina

    2009-01-01

    OBJECTIVE To evaluate the time course of leptin, adiponectin, and resting energy expenditure (REE) responses in overweight elderly males after acute resistance exercise protocols of various intensity configurations. RESEARCH DESIGN AND METHODS Forty inactive men (65–82 years) were randomly assigned to one of four groups (n = 10/group): control, low-intensity resistance exercise, moderate-intensity resistance exercise, and high-intensity resistance exercise. Exercise energy cost, REE, leptin, ...

  12. Effect of prior immobilization on muscular glucose clearance in resting and running rats

    International Nuclear Information System (INIS)

    In vitro studies have shown that prior disuse impairs the glucose clearance of red skeletal muscle because of a developed insensitivity to insulin. We studied whether an impaired glucose clearance is present in vivo in 42-h immobilized muscles of resting rats and, furthermore, whether the exercise-induced increase in glucose clearance of red muscles is affected by prior immobilization. The 2-[3H]deoxy-D-glucose (2DG) bolus injection method was used to determine glucose clearance of individual muscles. At rest, glucose clearance was markedly impaired in rats with previously immobilized red muscles compared with nonimmobilized control rats. During running, glucose clearance did not differ between muscles in previously immobilized and control rats. Insulin levels were always similar in the two groups and decreased during exercise. Intracellular nonphosphorylated 2DG was present in tissues with high glucose clearances. In conclusion, 42 h of immobilization markedly impairs glucose clearance of resting red muscle fibers in vivo. Apparently, physical inactivity in particular affects steps involved in insulin-mediated action that are not part of contraction-induced glucose uptake and metabolism. Presence of intracellular 2DG shows that separate determination of phosphorylated 2DG is necessary for accurate estimates of glucose metabolism and that accumulation of phosphorylated 2DG does not accurately reflect glucose transport

  13. Mathematical simulation of gamma-radiation angle distribution measurements

    International Nuclear Information System (INIS)

    We developed mathematical model of the facility for gamma-radiation angle distribution measurement and calculated response functions for gamma-radiation intensities. We developed special software for experimental data processing, the 'Shelter' object radiation spectra unfolding and Sphere detector (ShD) angle resolution estimation. Neuronet method using for detection of the radiation directions is given. We developed software based on the neuronet algorithm, that allows obtaining reliable distribution of gamma-sources that make impact on the facility detectors at the measurement point. 10 refs.; 15 figs.; 4 tab

  14. Automatic selection of resting-state networks with functional magnetic resonance imaging

    Directory of Open Access Journals (Sweden)

    Silvia Francesca eStorti

    2013-05-01

    Full Text Available Functional magnetic resonance imaging (fMRI during a resting-state condition can reveal the co-activation of specific brain regions in distributed networks, called resting-state networks, which are selected by independent component analysis (ICA of the fMRI data. One of the major difficulties with component analysis is the automatic selection of the ICA features related to brain activity. In this study we describe a method designed to automatically select networks of potential functional relevance, specifically, those regions known to be involved in motor function, visual processing, executive functioning, auditory processing, memory, and the default-mode network. To do this, image analysis was based on probabilistic ICA as implemented in FSL software. After decomposition, the optimal number of components was selected by applying a novel algorithm which takes into account, for each component, Pearson's median coefficient of skewness of the spatial maps generated by FSL, followed by clustering, segmentation, and spectral analysis. To evaluate the performance of the approach, we investigated the resting-state networks in 25 subjects. For each subject, three resting-state scans were obtained with a Siemens Allegra 3 T scanner (NYU data set. Comparison of the visually and the automatically identified neuronal networks showed that the algorithm had high accuracy (first scan: 95%, second scan: 95%, third scan: 93% and precision (90%, 90%, 84%. The reproducibility of the networks for visual and automatic selection was very close: it was highly consistent in each subject for the default-mode network (≥ 92% and the occipital network, which includes the medial visual cortical areas (≥ 94%, and consistent for the attention network (≥ 80%, the right and/or left lateralized frontoparietal attention networks, and the temporal-motor network (≥ 80%. The automatic selection method may be used to detect neural networks and reduce subjectivity in ICA

  15. Correlation of an abnormal rest 201Tl myocardial image: Pathological findings in cardiac transplant recipients

    International Nuclear Information System (INIS)

    Rest myocardial 201Tl scintigraphy was undertaken in 15 males mean age 39 years (22-54) who had been accepted for cardiac transplantation. Complete pathological correlation was obtained in 14 after transplantation and in 1 who died before a suitable donor heart became available. The average time from scintigraphy to pathological evaluation was 42 days (9-103). All the 201Tl images were grossly abnormal and on the basis of these studies it was not possible to differentiate ischemic from idiopathic cardiomyopathy. Each of the three views of the 201Tl study was divided into three segments, therefore 135 areas were available for comparison (3 x 3 x 15). Eighty-eight of these were abnormal on scan and 78 of these were abnormal pathologically. The right ventricle was seen on all rest images but the degree of uptake bore no relationship to the measured thickness of the right ventricular wall. Structures such as the atrial wall and the enlarged papillary muscle were visualized in some patients. In two patients there was an improvement of the rest 201Tl image in delayed views and histologically these areas showed a mixture of muscle and fibrous tissue. The sensitivity of 201Tl imaging in this study was 89% and there was close correlation of the images with gross and microscopic pathological findings. (orig.)

  16. Scale-free and multifractal properties of fMRI signals during rest and task

    Directory of Open Access Journals (Sweden)

    PhilippeCIUCIU

    2012-06-01

    Full Text Available Scale-free (or 1/f spectral properties in functional MRI (fMRI signals have been evidenced for a decade as intrinsic characteristics of ongoing brain activity [46]. Recently, they were shown to fluctuate across brain networks and to be modulated between rest and task [26]: Notably, Hurst exponent, quantifying long memory, decreases during task in activating and deactivating brain regions. Such results were obtained using tools assuming Gaussianity and self-similar models, while fMRI signals may significantly depart from those two assumptions [16] and were often based on voxelwise or regionwise independent analysis, hence showing large inter-subject variability. The present article aims at contributing to the analysis of scale-free properties of fMRI signals in two respects. First, a recent statistical analysis tool, the Wavelet Leader-based Multifractal formalism (WLMF, is used [45,3]. It shows improved estimation performance, and it is framed within a richer and more versatile class of models, that of multifractal processes. Second, scale-free properties are not investigated at the voxel or region scale. Instead, resting-state brain networks are extracted using a Multi-Subject Dictionary Learning (MSDL algorithm [40]: It produces both a set of spatial components, and a set of times series, for each component and each subject, that conveys ongoing dynamics in functional networks but also in artifacts. These combined tools are applied to an fMRI dataset comprising 12-subjects with resting-state and activation runs [36]. This dataset enabled us to confirm the task-related decrease of long memory in functional networks but also in artifacts making this feature not specific to functional networks. Also, most of fMRI signals appear multifractal at rest except in non-cortical regions. Task-related modulation of multifractality appears only significant in functional networks and thus becomes the key property to disentangle functional networks from

  17. Calcium supplementation and 4-week exercise on blood parameters of athletes at rest and exhaustion.

    Science.gov (United States)

    Cinar, Vedat; Mogulkoc, Rasim; Baltaci, Abdulkerim Kasim

    2010-05-01

    In the present study, experiments were designed to investigate if supplementation with calcium during 4 weeks had an effect on blood parameters in sedentary male athletes at rest and exhaustion. Thirty healthy subjects of ages ranging from 18 to 22 years were included in the study. The subjects were separated into three groups, as follows: Group 1 consisted sedentary athletes receiving 35 mg/kg/day calcium gluconate. Group 2 included subjects equally supplemented with calcium training 90 min/day for 5 days/week. Group 3 were subject to the same exercise regime but did not receive calcium supplements. Blood parameters were determined in the experimental subjects at rest and after exhaustion. The leukocyte count (WBC) of athletes in groups 2 and 3 were significantly higher at exhaustion (p WBC of the two supplemented groups. The erythrocyte count (RBC) was increased in the supplemented athletes after training (p athletes after exhaustion while other hematological parameters remain unchanged. PMID:19652928

  18. Correlation of hemodynamic and fluorescence signals under resting state conditions in mice's barrel field cortex.

    Science.gov (United States)

    Bélanger, Samuel; Oliveira Ferreira de Souza, Bruno; Casanova, Christian; Lesage, Frédéric

    2016-03-11

    Both neurons and astrocytes are known to affect local vascular response in the brain following neuronal activity. In order to differentiate the contributions of each cell type to the hemodynamic response during stimulation and resting state, intrinsic optical signal (IOI) was recorded synchronized with fluorescence imaging of calcium concentration sensitive dye Oregon Green BAPTA-1 AM. By changing the stimulation parameters (frequency and duration), it was possible to individually promote neuronal and glial responses and to compare them to levels of oxy (HbO), deoxy (HbR) and total (HbT) hemoglobin concentrations. Finally, resting state recordings were done to investigate the possible correlation between hemoglobin fluctuation and calcium transients, based on different frequency bands associated either with neuronal or glial activity. PMID:26850574

  19. Machine learning classification of resting state functional connectivity predicts smoking status

    Directory of Open Access Journals (Sweden)

    Vani ePariyadath

    2014-06-01

    Full Text Available Machine learning-based approaches are now able to examine functional magnetic resonance imaging data in a multivariate manner and extract features predictive of group membership. We applied support vector machine-based classification to resting state functional connectivity data from nicotine-dependent smokers and healthy controls to identify brain-based features predictive of nicotine dependence. By employing a network-centered approach, we observed that within-network functional connectivity measures offered maximal information for predicting smoking status, as opposed to between-network connectivity, or the representativeness of each individual node with respect to its parent network. Further, our analysis suggests that connectivity measures within the executive control and frontoparietal networks are particularly informative in predicting smoking status. Our findings suggest that machine learning-based approaches to classifying resting state functional connectivity data offer a valuable alternative technique to understanding large-scale differences in addiction-related neurobiology.

  20. Effects of Physical Exercise on Individual Resting State EEG Alpha Peak Frequency

    Directory of Open Access Journals (Sweden)

    Boris Gutmann

    2015-01-01

    Full Text Available Previous research has shown that both acute and chronic physical exercises can induce positive effects on brain function and this is associated with improvements in cognitive performance. However, the neurophysiological mechanisms underlying the beneficial effects of exercise on cognitive processing are not well understood. This study examined the effects of an acute bout of physical exercise as well as four weeks of exercise training on the individual resting state electroencephalographic (EEG alpha peak frequency (iAPF, a neurophysiological marker of the individual’s state of arousal and attention, in healthy young adults. The subjects completed a steady state exercise (SSE protocol or an exhaustive exercise (EE protocol, respectively, on two separate days. EEG activity was recorded for 2 min before exercise, immediately after exercise, and after 10 min of rest. All assessments were repeated following four weeks of exercise training to investigate whether an improvement in physical fitness modulates the resting state iAPF and/or the iAPF response to an acute bout of SSE and EE. The iAPF was significantly increased following EE (P=0.012 but not following SSE. It is concluded that the iAPF is increased following intense exercise, indicating a higher level of arousal and preparedness for external input.

  1. Angling for ecological effects of marine protection (SW Portugal

    Directory of Open Access Journals (Sweden)

    Maria João Tavares

    2015-10-01

    Multivariate analyses of the abundance of fish caught by size class found significant effects of protection in shore angling total weight (higher values in MPA. Lack of significant effects of protection may be due to the fact that MPAs are still recent. Replication in time, within a monitoring programme, is recommended to assess the ecological effects of these conservation measures.

  2. Rest life time management of Kozloduy NPP units 3 and 4

    International Nuclear Information System (INIS)

    Unit 3 and Unit 4 of NPP Kozloduy are second-generation WWER440/230 energy reactors. Unit 3 was in operation from 1980, Unit 4 - from 1982. No surveillance specimens for monitoring of RPV metal aging are available for both KNPP Units. The reactor pressure vessels rest lifetime assessment, Plant life management and Surveillance program development for the both units are presented and analyzed in this report. (author)

  3. Tendon vibration attenuates superficial venous vessel response of the resting limb during static arm exercise

    OpenAIRE

    Ooue Anna; Sato Kohei; Hirasawa Ai; Sadamoto Tomoko

    2012-01-01

    Abstract Background The superficial vein of the resting limb constricts sympathetically during exercise. Central command is the one of the neural mechanisms that controls the cardiovascular response to exercise. However, it is not clear whether central command contributes to venous vessel response during exercise. Tendon vibration during static elbow flexion causes primary muscle spindle afferents, such that a lower central command is required to achieve a given force without altering muscle ...

  4. The Effect of Aging on Resting-State Brain Function: An fMRI Study

    Directory of Open Access Journals (Sweden)

    A. H. Batouli

    2009-11-01

    Full Text Available Background/Objective: Healthy aging may be accompanied by some types of cognitive impairment; moreover, normal aging may cause natural atrophy in the healthy human brain. The hypothesis of the healthy aging brain is the structural changes together with the functional impairment happening. The brain struggles to over-compensate for those functional age-related impairments to continue as a healthy brain in its functions. Our goal in this study was to evaluate the effects of aging on the resting-state activation network of the brain using the multi-session probabilistic independent component analysis algorithm (PICA. "nPatients and Methods: We compared the resting-state brain activities between two groups of healthy aged and young subjects, so we examined 30 right-handed subjects and finally 12 healthy aging and 11 controls were enrolled in the study. "nResults: Our results showed that during the resting-state, older brains benefit from larger areas of activation, while in young competent brains, higher activation occurs in terms of greater intensity. These results were obtained in prefrontal areas as regions with regard to memory function as well as the posterior cingulate cortex (PCC as parts of the default mode network. Meanwhile, we reached the same results after normalization of activation size with total brain volume. "nConclusion: The difference in activation patterns between the two groups shows the brain's endeavor to compensate the functional impairment.

  5. EEG Resting-State Brain Topological Reorganization as a Function of Age

    Science.gov (United States)

    Petti, Manuela; Toppi, Jlenia; Mattia, Donatella; Astolfi, Laura

    2016-01-01

    Resting state connectivity has been increasingly studied to investigate the effects of aging on the brain. A reduced organization in the communication between brain areas was demonstrated by combining a variety of different imaging technologies (fMRI, EEG, and MEG) and graph theory. In this paper, we propose a methodology to get new insights into resting state connectivity and its variations with age, by combining advanced techniques of effective connectivity estimation, graph theoretical approach, and classification by SVM method. We analyzed high density EEG signals recorded at rest from 71 healthy subjects (age: 20–63 years). Weighted and directed connectivity was computed by means of Partial Directed Coherence based on a General Linear Kalman filter approach. To keep the information collected by the estimator, weighted and directed graph indices were extracted from the resulting networks. A relation between brain network properties and age of the subject was found, indicating a tendency of the network to randomly organize increasing with age. This result is also confirmed dividing the whole population into two subgroups according to the age (young and middle-aged adults): significant differences exist in terms of network organization measures. Classification of the subjects by means of such indices returns an accuracy greater than 80%. PMID:27006652

  6. Small angle elastic scattering of electrons by noble gas atoms

    International Nuclear Information System (INIS)

    In this thesis, measurements are carried out to obtain small angle elastic differential cross sections in order to check the validity of Kramers-Kronig dispersion relations for electrons scattered by noble gas atoms. First, total cross sections are obtained for argon, krypton and xenon. Next, a parallel plate electrostatic energy analyser for the simultaneous measurement of doubly differential cross section for small angle electron scattering is described. Also absolute differential cross sections are reported. Finally the forward dispersion relation for electron-helium collisions is dealt with. (Auth.)

  7. Precise predictions of neutrino mixing angles and $CP$ phase

    CERN Document Server

    Abbas, Gauhar

    2016-01-01

    The neutrino mixing parameters are studied using renormalization-group evolution of Dirac neutrinos with recently proposed parameterization of the neutrino mixing angles referred as `high-scale mixing relations'. The correlations among all neutrino mixing and $CP$ violating parameters are investigated. The predictions for the neutrino mixing angles and the $CP$ phase are precise and could be easily tested by ongoing and future experiments. We observe that the high scale mixing unification hypothesis is incompatible with Dirac neutrinos due to updated experimental data.

  8. Investigation of Brazed Plate Heat Exchangers With Variable Chevron Angles

    Directory of Open Access Journals (Sweden)

    S. Muthuraman

    2013-08-01

    Full Text Available - Experiments to measure the condensation heat transfer coefficient and the pressure drop in brazed plate heat exchangers (BPHEs were performed with the refrigerants R410A and R22. Brazed plate heat exchangers with different chevron angles of 45°, 35°, and 20° were used. Varying the mass flux, the condensation temperature, and the vapor quality of the refrigerant, we measured the condensation heat transfer coefficient and the pressure drops. Both the heat transfer coefficient and the pressure drop increased proportionally with the mass flux and the vapor quality and inversely with the condensation temperature and the chevron angle.

  9. Triangulations of hyperbolic 3-manifolds admitting strict angle structures

    CERN Document Server

    Hodgson, Craig D; Segerman, Henry

    2011-01-01

    It is conjectured that every cusped hyperbolic 3-manifold has a decomposition into positive volume ideal hyperbolic tetrahedra (a "geometric" triangulation of the manifold). Under a mild homology assumption on the manifold we construct topological ideal triangulations which admit a strict angle structure, which is a necessary condition for the triangulation to be geometric. In particular, every knot or link complement in the 3-sphere has such a triangulation. We also give an example of a triangulation without a strict angle structure, where the obstruction is related to the homology hypothesis, and an example illustrating that the triangulations produced using our methods are not generally geometric.

  10. Testing a dual-systems model of adolescent brain development using resting-state connectivity analyses.

    Science.gov (United States)

    van Duijvenvoorde, A C K; Achterberg, M; Braams, B R; Peters, S; Crone, E A

    2016-01-01

    The current study aimed to test a dual-systems model of adolescent brain development by studying changes in intrinsic functional connectivity within and across networks typically associated with cognitive-control and affective-motivational processes. To this end, resting-state and task-related fMRI data were collected of 269 participants (ages 8-25). Resting-state analyses focused on seeds derived from task-related neural activation in the same participants: the dorsal lateral prefrontal cortex (dlPFC) from a cognitive rule-learning paradigm and the nucleus accumbens (NAcc) from a reward-paradigm. Whole-brain seed-based resting-state analyses showed an age-related increase in dlPFC connectivity with the caudate and thalamus, and an age-related decrease in connectivity with the (pre)motor cortex. nAcc connectivity showed a strengthening of connectivity with the dorsal anterior cingulate cortex (ACC) and subcortical structures such as the hippocampus, and a specific age-related decrease in connectivity with the ventral medial PFC (vmPFC). Behavioral measures from both functional paradigms correlated with resting-state connectivity strength with their respective seed. That is, age-related change in learning performance was mediated by connectivity between the dlPFC and thalamus, and age-related change in winning pleasure was mediated by connectivity between the nAcc and vmPFC. These patterns indicate (i) strengthening of connectivity between regions that support control and learning, (ii) more independent functioning of regions that support motor and control networks, and (iii) more independent functioning of regions that support motivation and valuation networks with age. These results are interpreted vis-à-vis a dual-systems model of adolescent brain development. PMID:25969399

  11. Effect of treadmill training on peak expiratory flow rate and resting pulse rate among young adult

    Directory of Open Access Journals (Sweden)

    SUKANYA BARDHAN

    2013-01-01

    Full Text Available The present was designed to find out the effect of treadmill training on peak expiratory flow rate and resting pulse rate among young adult boys. The random group design was adopted for this study. Participants were randomly assigned to experimental and control groups. For this purpose, Ten (N = 10 male students of B.A., B.C.A and B.Com from Post Graduate Government College, Sector-11, Chandigarh aged 19-25 years participate in the study. The subjects were being randomly divided into two groups: A (N = 05; Experimental and B (N = 05; Control. Paired "t" test was employed to identify significant differences between the pretest and post-test mean of the two groups through Medical Calculation Version 12.5. To test the hypotheses, the level of significance was set at 0.05. It is concluded that insignificant difference has been found between pre-test and post test (Experimental Group scores of Peak Expiratory Flow Rate (PEFR among young adult boys. No significant difference has been found between the pre-test and post-test(Control Group scores of Peak Expiratory Flow Rate (PEFR among young adult boys. No significant difference has been found between the pre-test and post-test (Experimental Group scores of Resting Pulse Rate among young adult boys. No significant difference has been found between the pre-test and post-test (Control Group scores of Resting Pulse Rate among young adult boys.

  12. Effect of smoking on the central circulation at rest and during exercise as studied by radiocardiography

    International Nuclear Information System (INIS)

    The pulmonary vessels are the first target of tobacco smoke in the circulatory system, but the functional changes occuring in the pulmonary circulation are poorly understood. Hence 46 volunteers were studied by radiocardiography under the following conditions: 1. At rest before and after smoking 2 cigarettes (15 men); 2. After repeated ergometer exercise (5 min. 100 W) with and without smoking (13 men); and 3. Control experiments under the corresponding conditions without smoking (18 subjects). A significant increase occured in heart rate, cardiac output and systolic arterial blood pressure after smoking when at rest, but an almost significant decrease in pulmonary dispersion volume, whereas the heart rate and pulmonary capillary pressure attained significantly higher values after than before smoking in the exercise tests, with a significant decrease observed in stroke volume, pulmonary blood volume and pulmonary dispersion volume. It is concluded that smoking impairs physical performance increases pulmonary capillary pressure and reduces pulmonary blood volume and probably the number of open capillaries. (orig.)

  13. Classification of schizophrenia patients based on resting-state functional network connectivity

    Directory of Open Access Journals (Sweden)

    Mohammad Reza Arbabshirani

    2013-07-01

    Full Text Available There is a growing interest in automatic classification of mental disorders based on neuroimaging data. Small training data sets (subjects and very large amount of high dimensional data make it a challenging task to design robust and accurate classifiers for heterogeneous disorders such as schizophrenia. Most previous studies considered structural MRI, diffusion tensor imaging and task-based fMRI for this purpose. However, resting-state data has been rarely used in discrimination of schizophrenia patients from healthy controls. Resting data are of great interest, since they are relatively easy to collect, and not confounded by behavioral performance on a task. Several linear and non-linear classification methods were trained using a training dataset and evaluate with a separate testing dataset. Results show that classification with high accuracy is achievable using simple non-linear discriminative methods such as k-nearest neighbors which is very promising. We compare and report detailed results of each classifier as well as statistical analysis and evaluation of each single feature. To our knowledge our effects represent the first use of resting-state functional network connectivity features to classify schizophrenia.

  14. Decreased thalamocortical functional connectivity after 36 hours of total sleep deprivation: evidence from resting state FMRI.

    Directory of Open Access Journals (Sweden)

    Yongcong Shao

    Full Text Available OBJECTIVES: The thalamus and cerebral cortex are connected via topographically organized, reciprocal connections, which hold a key function in segregating internally and externally directed awareness information. Previous task-related studies have revealed altered activities of the thalamus after total sleep deprivation (TSD. However, it is still unclear how TSD impacts on the communication between the thalamus and cerebral cortex. In this study, we examined changes of thalamocortical functional connectivity after 36 hours of total sleep deprivation by using resting state function MRI (fMRI. MATERIALS AND METHODS: Fourteen healthy volunteers were recruited and performed fMRI scans before and after 36 hours of TSD. Seed-based functional connectivity analysis was employed and differences of thalamocortical functional connectivity were tested between the rested wakefulness (RW and TSD conditions. RESULTS: We found that the right thalamus showed decreased functional connectivity with the right parahippocampal gyrus, right middle temporal gyrus and right superior frontal gyrus in the resting brain after TSD when compared with that after normal sleep. As to the left thalamus, decreased connectivity was found with the right medial frontal gyrus, bilateral middle temporal gyri and left superior frontal gyrus. CONCLUSION: These findings suggest disruptive changes of the thalamocortical functional connectivity after TSD, which may lead to the decline of the arousal level and information integration, and subsequently, influence the human cognitive functions.

  15. The rest-frame optical luminosity functions of galaxies at 2

    CERN Document Server

    Marchesini, D; Quadri, R; Rudnick, G; Franx, M; Lira, P; Wuyts, S; Gawiser, E; Christlein, D; Toft, S; Marchesini, Danilo; Dokkum, Pieter van; Quadri, Ryan; Rudnick, Gregory; Franx, Marijn; Lira, Paulina; Wuyts, Stijn; Gawiser, Eric; Christlein, Daniel; Toft, Sune

    2006-01-01

    [ABRIDGED] We present the rest-frame optical (B, V, and R-band) luminosity functions (LFs) of galaxies at 22 are consistent with those in the local LFs. The characteristic magnitudes are significantly brighter than the local values, while the measured values for Phi_star are a factor of ~5 smaller with respect to the local values. By integrating the LFs, we estimate the number and luminosity densities. We present for the first time the LF of Distant Red Galaxies (DRGs; defined here as z>2 sources with observed J-K>2.3). While DRGs and non-DRGs are characterized by similar LFs at the bright end, the faint-end slope of the non-DRG LF is much steeper than that of DRGs. Comparing the rest-frame V-band LF of non-DRGs to that inferred for Lyman break galaxies by Shapley et al. (2001), we find a significantly less steep faint-end slope. The contribution of DRGs to the global densities is 14%-25% in number and 22%-33% in luminosity. From the rest-frame U-V colors and stellar population synthesis models, we estimate t...

  16. Repetitive tactile stimulation changes resting-state functional connectivity – implications for treatment of sensorimotor decline

    Directory of Open Access Journals (Sweden)

    Frank Freyer

    2012-05-01

    Full Text Available Neurological disorders and physiological aging can lead to a decline of perceptual abilities. In contrast to the conventional therapeutic approach that comprises intensive training and practicing, passive repetitive sensory stimulation (RSS has recently gained increasing attention as an alternative to countervail the sensory decline by improving perceptual abilities without the need of active participation. A particularly effective type of high-frequency RSS, utilizing Hebbian learning principles, improves perceptual acuity as well as sensorimotor functions and has been successfully applied to treat chronic stroke patients and elderly subjects. High-frequency RSS has been shown to induce plastic changes of somatosensory cortex such as representational map reorganization, but its impact on the brain’s ongoing network activity and resting-state functional connectivity has not been investigated so far. Here, we applied high-frequency RSS in healthy human subjects and analyzed resting state Electroencephalography (EEG functional connectivity patterns before and after RSS by means of imaginary coherency (ImCoh, a frequency-specific connectivity measure which is known to reduce overestimation biases due to volume conduction and common reference. Thirty minutes of passive high-frequency RSS lead to significant ImCoh-changes of the resting state mu-rhythm in the individual upper alpha frequency band within distributed sensory and motor cortical areas. These stimulation induced distributed functional connectivity changes likely underlie the previously observed improvement in sensorimotor integration.

  17. Resting-state functional connectivity of the default mode network associated with happiness.

    Science.gov (United States)

    Luo, Yangmei; Kong, Feng; Qi, Senqing; You, Xuqun; Huang, Xiting

    2016-03-01

    Happiness refers to people's cognitive and affective evaluation of their life. Why are some people happier than others? One reason might be that unhappy people are prone to ruminate more than happy people. The default mode network (DMN) is normally active during rest and is implicated in rumination. We hypothesized that unhappiness may be associated with increased default-mode functional connectivity during rest, including the medial prefrontal cortex (MPFC), posterior cingulate cortex (PCC) and inferior parietal lobule (IPL). The hyperconnectivity of these areas may be associated with higher levels of rumination. One hundred forty-eight healthy participants underwent a resting-state fMRI scan. A group-independent component analysis identified the DMNs. Results indicated increased functional connectivity in the DMN was associated with lower levels of happiness. Specifically, relative to happy people, unhappy people exhibited greater functional connectivity in the anterior medial cortex (bilateral MPFC), posterior medial cortex regions (bilateral PCC) and posterior parietal cortex (left IPL). Moreover, the increased functional connectivity of the MPFC, PCC and IPL, correlated positively with the inclination to ruminate. These results highlight the important role of the DMN in the neural correlates of happiness, and suggest that rumination may play an important role in people's perceived happiness. PMID:26500289

  18. Effects of Heliox in Stable COPD Patients at Rest and during Exercise

    Directory of Open Access Journals (Sweden)

    Matteo Pecchiari

    2012-01-01

    Full Text Available Heliox has been administered to stable chronic obstructive pulmonary disease (COPD patients at rest and during exercise on the assumption that this low density mixture would have reduced work of breathing, dynamic hyperinflation, and, consequently, dyspnea sensation. Contrary to these expectations, beneficial effects of heliox in these patients at rest have been reported only sporadically, and the majority of the studies performed until now suggests that heliox is not a therapeutic option in spontaneously breathing resting COPD patients. On the other hand, when it is administered to COPD patients exercising at a constant work rate, heliox systematically decreases dyspnea sensation, and, often but not always, increases exercise tolerance. For these reasons, heliox has been evaluated as a non pharmacological tool to power rehabilitation programs. The conflicting results provided by the published trials probably point at a substantial heterogeneity of the COPD patients population in terms of respiratory mechanics and gas exchange. Therefore, further studies, aimed to the identification of mechanisms conditioning the response of exercising COPD patients to heliox, are warranted, before heliox administration, which is costly and cumbersome, can be routinely used in rehabilitation programs.

  19. Pharmacological exploration of the resting membrane potential reserve: Impact on atrial fibrillation.

    Science.gov (United States)

    van der Heyden, Marcel A G; Jespersen, Thomas

    2016-01-15

    The cardiac action potential arises and spreads throughout the myocardium as a consequence of highly organized spatial and temporal expression of ion channels conducting Na(+), Ca(2+) or K(+) currents. The cardiac Na(+) current is responsible for the initiation and progression of the action potential. Altered Na(+) current has been found implicated in a number of different arrhythmias, including atrial fibrillation. In the atrium, the resting membrane potential is more depolarized than in the ventricles, and as cardiac Na(+) channels undergo voltage-dependent inactivation close to this potential, minor changes in the membrane potential have a relatively large impact on the atrial Na(+) current. The atrial resting membrane potential is established following ionic currents through the inwardly rectifying K(+) currents IK1, IK,ACh and IK,Ca and to a lesser extent by other ion channels as well as by exchangers and pumps. This review will focus on the relative and regulated contribution of IK1, IK,ACh and IK,Ca, and on pharmacological modification of the channels underlying these currents in respect to the resting membrane potential, Na(+) channel availability and atrial electrophysiology in health and disease. PMID:26601803

  20. Sonographic evaluation of resting gallbladder volume and postprandial emptying in patients with gallstones.

    Science.gov (United States)

    Kishk, S M; Darweesh, R M; Dodds, W J; Lawson, T L; Stewart, E T; Kern, M K; Hassanein, E H

    1987-05-01

    We investigated fasting gallbladder volume and gallbladder emptying in response to a fatty meal in 20 patients with asymptomatic gallstones and compared the results with findings from healthy controls. Compared with control subjects without gallstones, the majority of patients with gallstones exhibited a higher resting gallbladder volume, less fractional emptying after a fatty meal, and a higher postmeal residual volume. These abnormalities all appeared to stem from an abnormally high resting gallbladder volume. Whether the increased gallbladder volume and decreased postprandial fractional emptying in the gallstone patients represents a primary or secondary abnormality remains to be determined. The results suggest that in some patients decreased gallbladder contractility may contribute to gallstone development or proliferation. PMID:3554918

  1. Comparison of five equations for estimating resting energy expenditure in Chinese young, normal weight healthy adults

    OpenAIRE

    Rao Zhi-yong; Wu Xiao-ting; Liang Bin-miao; Wang Mao-yun; Hu Wen

    2012-01-01

    Abstract Background Most resting energy expenditure (REE) predictive equations for adults were derived from research conducted in western populations; whether they can also be used in Chinese young people is still unclear. Therefore, we conducted this study to determine the best REE predictive equation in Chinese normal weight young adults. Methods Forty-three (21 male, 22 female) healthy college students between the age of 18 and 25 years were recruited. REE was measured by the indirect calo...

  2. Form pressure generated by self-compacting concrete : influence of thixotropy and structural behaviour at rest

    OpenAIRE

    Billberg, Peter

    2006-01-01

    Self-compacting concrete (SCC) offers rational and fast casting process since it merely has to be poured, or pumped, into the formwork without any compaction work needed. But this can be at the cost of high form pressure. However, reported results show that SCC can act thixotropically, i.e., build up a structure at rest, and this can reduce the form pressure considerably. Thus, in order to utilise the favourable possibilities to increase effectiveness without risking form collapses, the need ...

  3. Effects of Commercially Available Dietary Supplements on Resting Energy Expenditure: A Brief Report

    OpenAIRE

    Vaughan, Roger A.; Conn, Carole A.; Mermier, Christine M.

    2014-01-01

    Commercially available dietary products advertised to promote weight loss are an underresearched but heavily purchased commodity in the United States. Despite only limited evidence, interest in dietary supplements continues to increase. This work uniquely summarizes the current evidence evaluating the efficacy of several over-the-counter thermogenic products for their effects on resting energy expenditure. Currently, there is some evidence suggesting dietary products containing select ingredi...

  4. Hypnotic modulation of resting state fMRI default mode and extrinsic network connectivity

    OpenAIRE

    Demertzi, Athina; Soddu, Andrea; Faymonville, Marie-Elisabeth; Bahri, Mohamed Ali; Gosseries, Olivia; Vanhaudenhuyse, Audrey; Phillips, Christophe; Maquet, Pierre; Luxen, André; Laureys, Steven

    2011-01-01

    Resting state fMRI (functional magnetic resonance imaging) acquisitions are characterized by low-frequency spontaneous activity in a default mode network (encompassing medial brain areas and linked to self-related processes) and an anticorrelated “extrinsic” system (encompassing lateral frontoparietal areas and modulated via external sensory stimulation). In order to better determine the functional contribution of these networks to conscious awareness, we here sought to transiently modulat...

  5. Catechol-O-methyltransferase (COMT) influences the connectivity of the prefrontal cortex at rest

    OpenAIRE

    Tunbridge, Elizabeth M.; Farrell, Sarah M.; Harrison, Paul J; Mackay, Clare E

    2013-01-01

    Catechol-O-methyltransferase (COMT) modulates dopamine in the prefrontal cortex (PFC) and influences PFC dopamine-dependent cognitive task performance. A human COMT polymorphism (Val158Met) alters enzyme activity and is associated with both the activation and functional connectivity of the PFC during task performance, particularly working memory. Here, we used functional magnetic resonance imaging and a data-driven, independent components analysis (ICA) approach to compare resting state funct...

  6. Neural encoding of objects relevant for navigation and resting state correlations with navigational ability.

    Science.gov (United States)

    Wegman, Joost; Janzen, Gabriele

    2011-12-01

    Objects along a route can help us to successfully navigate through our surroundings. Previous neuroimaging research has shown that the parahippocampal gyrus (PHG) distinguishes between objects that were previously encountered at navigationally relevant locations (decision points) and irrelevant locations (nondecision points) during simple object recognition. This study aimed at unraveling how this neural marking of objects relevant for navigation is established during learning and postlearning rest. Twenty-four participants were scanned using fMRI while they were viewing a route through a virtual environment. Eye movements were measured, and brain responses were time-locked to viewing each object. The PHG showed increased responses to decision point objects compared with nondecision point objects during route learning. We compared functional connectivity between the PHG and the rest of the brain in a resting state scan postlearning with such a scan prelearning. Results show that functional connectivity between the PHG and the hippocampus is positively related to participants' self-reported navigational ability. On the other hand, connectivity with the caudate nucleus correlated negatively with navigational ability. These results are in line with a distinction between egocentric and allocentric spatial representations in the caudate nucleus and the hippocampus, respectively. Our results thus suggest a relation between navigational ability and a neural preference for a specific type of spatial representation. Together, these results show that the PHG is immediately involved in the encoding of navigationally relevant object information. Furthermore, they provide insight into the neural correlates of individual differences in spatial ability. PMID:21671733

  7. Towards an extension of 1905 relativistic dynamics with a variable rest mass measuring potential energy

    CERN Document Server

    Hidalgo-Gato, Rafael A Valls

    2012-01-01

    From a rigorous historic analysis of 1686 I. Newton and 1905 A. Einstein works where the last derived the universal mass-energy relationship, it is concluded that rest mass measures potential energy. From the same formula used to obtain that relation, it is derived the ratio Total Energy/Potential Energy is equal to the gamma relativistic factor. It is derived a formula for the variation of a body rest mass with its position in a gravity field, explaining with it the behavior of an atomic clock. It is revised the bodies free fall in a gravitational field, finding that a constant total mass is equal to the gravitational mass, while the variable rest mass is equal to the inertial mass, maintaining all an identical behavior independent of their masses. A revision of the E\\"otv\\"os experiment concludes that it is unable to detect the found difference between inertial and gravitational mass. Applying the extended 1905 relativistic dynamics to Mercury, its perihelion shift is determined; it is concluded with the co...

  8. Pharmacological modulation of pulvinar resting-state regional oscillations and network dynamics in major depression.

    Science.gov (United States)

    Tadayonnejad, Reza; Ajilore, Olusola; Mickey, Brian J; Crane, Natania A; Hsu, David T; Kumar, Anand; Zubieta, Jon-Kar; Langenecker, Scott A

    2016-06-30

    The pulvinar, the largest thalamus nucleus, has rich anatomical connections with several different cortical and subcortical regions suggesting its important involvement in high-level cognitive and emotional functions. Unfortunately, pulvinar dysfunction in psychiatric disorders particularly major depression disorder has not been thoroughly examined to date. In this study we explored the alterations in the baseline regional and network activities of the pulvinar in MDD by applying spectral analysis of resting-state oscillatory activity, functional connectivity and directed (effective) connectivity on resting-state fMRI data acquired from 20 healthy controls and 19 participants with MDD. Furthermore, we tested how pharmacological treatment with duloxetine can modulate the measured local and network variables in ten participants who completed treatment. Our results revealed a frequency-band dependent modulation of power spectrum characteristics of pulvinar regional oscillatory activity. At the network level, we found MDD is associated with aberrant causal interactions between pulvinar and several systems including default-mode and posterior insular networks. It was also shown that duloxetine treatment can correct or overcompensate the pathologic network behavior of the pulvinar. In conclusion, we suggest that pulvinar regional baseline oscillatory activity and its resting-state network dynamics are compromised in MDD and can be modulated therapeutically by pharmacological treatment. PMID:27148894

  9. Overview of Neutrino Mixing Models and Their Mixing Angle Predictions

    Energy Technology Data Exchange (ETDEWEB)

    Albright, Carl H.

    2009-11-01

    An overview of neutrino-mixing models is presented with emphasis on the types of horizontal flavor and vertical family symmetries that have been invoked. Distributions for the mixing angles of many models are displayed. Ways to differentiate among the models and to narrow the list of viable models are discussed.

  10. Method on camouflaged target recognition using the angle of ellipsometry

    Science.gov (United States)

    Zhuansun, Xiao-bo; Wu, Wen-Yuan; Huang, Yan-hua; Li, Zhao-zhao

    2015-10-01

    Using polarimetric information of the camouflaged target surface to identify camouflage has been a hot research area in camouflage detecting. The main method is to use the difference in the degree of polarization(DOP) between background and target to add the contrast ratio of them. The measurement of the DOP has some requirements on the intensity of reflected radiation. In case of low reflected radiation intensity, the difference in the DOP for different materials is not so distinguishable. In addition, the linear degree of polarization is largely under the effects of detection angle and surface roughness, so it is hard to differentiate the degree of polarization when the targets with similar surface roughness are detected at the same detection angle. By analyzing the elements affecting the reflected electromagnetic radiation amplitudes and phase on the camouflaged target surface, this article makes a research on the polarization character of reflected radiation A method on camouflaged target recognition directly or indirectly by taking the angle of ellipsometry (AOE) imaging under the linear polarized light. The function model of the angle of incidence, complex refractive index and AOE was modeled, then the model was simulated by MATLAB and the results showed it can describe the distribution properties of AOE. A new thought for the approach of identifying camouflaged target recognition by detecting polarimetric information was proposed, and it has a deep theoretical and practical significance in camouflaged target recognition.

  11. Combined surgical management of mandibular angle prominence and microgenia

    International Nuclear Information System (INIS)

    Chin play a very important role in facial aesthetics. Different deformities of volume and of position may occur at this level and it is the microgenia one of the more frequent. Treatment options include the use of silicone, alloplasty materials and autologous bone graft. Authors report the use of the bone removed from mandibular angle to increase the chin. This is the case of a white female patient aged 18 seen by the Orthognathics Multidisciplinary Staff of 'V. I. Lenin' Hospital due to its uncommon face width. The corresponding physical examination as well as the complementary ones diagnosed a bilateral prominence of mandibular angle associated with a microgenia. Surgery carried out was of remodeling type of both mandibular angles and genioplasty of height increase and a discrete advancement using the bone removed from the gonion. There were satisfactory aesthetic results without evidence of bone reabsorption. We conclude that use of autologous graft of mandibular angle is an effective treatment alternative for correction of microgenia. (author)

  12. Oscillations of relative inclination angles in compact extrasolar planetary systems

    Science.gov (United States)

    Becker, Juliette C.; Adams, Fred C.

    2016-01-01

    The Kepler mission has detected dozens of compact planetary systems with more than four transiting planets. This sample provides a collection of close-packed planetary systems with relatively little spread in the inclination angles of the inferred orbits. A large fraction of the observational sample contains limited multiplicity, begging the question whether there is a true diversity of multitransiting systems, or if some systems merely possess high mutual inclinations, allowing them to appear as single-transiting systems in a transit-based survey. This paper begins an exploration of the effectiveness of dynamical mechanisms in exciting orbital inclination within exoplanetary systems of this class. For these tightly packed systems, we determine that the orbital inclination angles are not spread out appreciably through self-excitation. In contrast, the two Kepler multiplanet systems with additional non-transiting planets are susceptible to oscillations of their inclination angles, which means their currently observed configurations could be due to planet-planet interactions alone. We also provide constraints and predictions for the expected transit duration variations for each planet. In these multiplanet compact Kepler systems, oscillations of their inclination angles are remarkably hard to excite; as a result, they tend to remain continually mutually transiting (CMT-stable). We study this issue further by augmenting the planet masses and determining the enhancement factor required for oscillations to move the systems out of transit. The oscillations of inclination found here inform the recently suggested dichotomy in the sample of Solar systems observed by Kepler.

  13. Comparison of Structural and Functional Ocular Outcomes Between 14- and 70 Day Bed Rest

    Science.gov (United States)

    Cromwell, R. L.; Taibbi, G.; Zanello, S. B.; Yarbough, P. O.; Ploutz-Snyder, R. J.; Vizzeri, G.

    2016-01-01

    Purpose: To compare structural and functional ocular outcomes in healthy human subjects undergoing 14- and/or 70-day head-down-tilt bed rest (HDTBR). We hypothesized the amount of HDTBR-induced ocular changes be affected by the HDTBR duration. Methods: The studies were conducted at the NASA Flight Analogs Research Unit, The University of Texas Medical Branch at Galveston, Galveston, TX. Participants were selected using NASA standard screening procedures. Standardized NASA screening procedures and bed rest conditions (e.g., strict sleep-wake cycle, standardized diet, continuous video monitoring) were implemented in both studies. Participants maintained a 6deg HDTBR position for 14 and/or 70 consecutive days and did not engage in exercise. Weekly ophthalmological examinations were conducted in the sitting (pre/post-bed rest only) and HDT positions. Ocular outcomes of interest included: near best-corrected visual acuity (BCVA); spherical equivalent, as determined by cycloplegic autorefraction; Goldmann applanation tonometry and iCare (Icare Finland Oy, Espoo, Finland) intraocular pressure (IOP) measurement; color vision; red dot test; modified Amsler grid test; confrontational visual field; stereoscopic color fundus photography; Spectralis OCT (Heidelberg Engineering, GmbH, Heidelberg, Germany) retinal nerve fiber layer thickness (RNFLT), peripapillary and macular retinal thicknesses. Mixed-effects linear models were used to compare pre- and post-HDTBR observations between 14- and 70-day HDTBR for our continuously scaled outcomes.

  14. Variation of the anal resting pressure induced by postexpiratory apnea effort in patients with constipation

    Directory of Open Access Journals (Sweden)

    Thaís Helena Benetti

    2011-03-01

    Full Text Available CONTEXT: Intestinal constipation - a common symptom among the general population - is more frequent in women. It may be secondary to an improper diet or organic or functional disturbances, such as dyskinesia of the pelvic floor. This is basically characterized by the absence of relaxation or paradoxical contraction of the pelvic floor and anal sphincter during evacuation. OBJECTIVE: To analyze, by manometric data, the anal pressure variation at rest, during evacuation effort by using the Valsalva maneuver and forced post-expiratory apnea in subjects with secondary constipation. METHODS: Twenty-one patients (19 females - 90.4% with a mean age of 47.5 years old (23-72 were studied. The diagnosis was performed using anorectal manometry, with a catheter containing eight channels disposed at the axial axis, measuring the proximal (1 and distal (2 portions of the anal orifice. The elevation of the pressure values in relation to the resting with the evacuation effort was present in all patients. The Agachan score was used for clinical evaluation of constipation. The variables studied were: mean anal pressure of the anal orifice for 20 seconds at rest, the effort of evacuation using Valsalva maneuver and the effort of evacuation during apnea after forced expiration, as well as the area under the curve of the manometric tracing at moments Valsalva and apnea. RESULTS: The analysis of the mean values of the anal pressure variation at rest evidenced difference between proximal and distal channels (P = 0.007, independent of the moment and tendency to differ during moments Valsalva and apnea (P = 0.06. The mean of values of the area under the manometric tracing curve showed differences between moments Valsalva and apnea (P = 0.0008, either at the proximal portion or at the distal portion of the anal orifice. CONCLUSION: The effort of evacuation associated with postexpiratory apnea, when compared with the effort associated with the Valsalva maneuver, provides

  15. Contrast-enhanced CISS imaging of cerebellopontine angle tumors

    Energy Technology Data Exchange (ETDEWEB)

    Tozaki, Mitsuhiro; Toyoda, Keiko; Hata, Yuichi; Fukuda, Yasushi; Fukuda, Kunihiko [Jikei Univ., Tokyo (Japan). School of Medicine; Katano, Shuichi

    1999-10-01

    Our purpose of this study was to evaluate the clinical usefulness of contrast-enhanced CISS-3DFT MR imaging for the diagnosis of CP angle tumors. CISS-3DFT MR imaging is expected for screening procedure of acoustic schwannoma because of excellent spatial resolution. Recently, we discovered contrast enhancement effect on CISS sequence in spite of heavily T{sub 2}-weighted images. Fourteen patients with CP angle tumors were performed on a 1.0 T MR unit. Transaxial CISS-3DFT MRI was obtained both before and after intravenous injections of Gd-DTPA. Multiplanar reconstructions (MPRs) were performed in all cases. Contrast enhancement effect of CP angle tumors, and the relationship between tumors and the adjacent cranial nerves were evaluated. Contrast enhancement effect of the tumors was present in all cases in spite of heavily T{sub 2}-weighted images of CISS sequences. In the internal auditory canal, relationship between the tumors and the cranial nerves was demonstrated in 6 cases (6/9). In the cerebellopontine cistern, all cases were demonstrated (11/11). Contrast-enhanced CISS-3DFT MR imaging with a good contrast resolution and an excellent spatial resolution is useful for the diagnosis of CP angle tumors. (author)

  16. Ultra Small-Angle Neutron Scattering Study of Porous Glass

    International Nuclear Information System (INIS)

    Compacts of silica micro-spheres prepared for different times at sintering temperatures of 640 deg. C and 740 deg. C have been studied by Ultra Small-Angle Neutron Scattering (USANS) and Scanning Electron Microscopy (SEM). Stress versus strain measurements display several breakage points related to a range of nearest neighbour coordination around each microsphere.

  17. An Analysis of the Morris Loe Angle Trisection Approximation.

    Science.gov (United States)

    Aslan, Farhad,; And Others

    1992-01-01

    Presents the Morris Loe Angle Trisection Approximation Method to introduce students to areas of mathematics where approximations are used when exact answers are difficult or impossible to obtain. Examines the accuracy of the method using the laws of sines and cosines and a BASIC computer program that is provided. (MDH)

  18. Non-linear Flight Dynamics at High Angles of Attack

    DEFF Research Database (Denmark)

    Granasy, P.; Sørensen, C.B.; Mosekilde, Erik; Thomasson, P.G.

    1998-01-01

    The methods of nonlinear dynamics are applied to the longitudinal motion of a vectored thrust aircraft, in particular the behavior at high angles of attack. Our model contains analytic nonlinear aerodynamical coefficients based on NASA windtunnel experiments on the F-18 high-alpha research vehicle...

  19. Progress Report of Small Angle Neutron Scattering on CARR

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    The project of small angle neutron scattering spectrometer (SANS) belongs to "building up the center for neutron scattering". It's one of the project "national science & technology infrastructure center". The building parts are already done in 2010. By the proposal one of

  20. Non-linear Flight Dynamics at High Angles of Attack

    DEFF Research Database (Denmark)

    Granasy, P.; Sørensen, C.B.; Mosekilde, Erik;

    1998-01-01

    The methods of nonlinear dynamics are applied to the longitudinal motion of a vectored thrust aircraft, in particular the behavior at high angles of attack. Our model contains analytic nonlinear aerodynamical coefficients based on NASA windtunnel experiments on the F-18 high-alpha research vehicl...

  1. Magnetic resonance imaging of functional connectivity in Parkinson disease in the resting brain

    International Nuclear Information System (INIS)

    Objective: To investigate functional connectivity changes in Parkinson disease in the resting brain using functional magnetic resonance imaging. Methods: Nine patients with Parkinson disease and eight age-matched healthy volunteers were entered into the study. The bilateral globus pallidus were chosen as seed points, the functional MR data acquired in the resting state were processed to investigate functional connectivity in PD patients and the results were compared with those of the controls. Results: In age-matched healthy controls, there are regions which had functional connectivity with bilateral globus pallidus, including bilateral temporal poles, bilateral hippocampus, bilateral thalami, posterior cingulate cortex, right middle occipital gyms and right superior parietal gyms. In PD patients, brain regions including bilateral cerebellum, left hippocampus, bilateral superior temporal gyri, left inferior frontal gyrus, left middle frontal gyrus, left precentral gyrus, left inferior parietal gyrus and left superior parietal gyrus, had functional connectivity with bilateral globus pallidus. Compared to healthy controls, increased functional connectivity in bilateral cerebellum, bilateral temporal lobes, left frontal lobe and left parietal lobe, and decreased functional connectivity in bilateral thalami were observed in PD patients. Conclusion: Abnormal changes of brain functional connectivity exists in Parkinson's disease in the resting state. (authors)

  2. Resting vagal control and resilience as predictors of cardiovascular allostasis in peacekeepers.

    Science.gov (United States)

    Souza, Gabriela Guerra Leal; Magalhães, Ludmila Naves; Cruz, Thiago Amorim Ribeiro Da; Mendonça-De-Souza, Ana Carolina Ferraz; Duarte, Antônio Fernando A; Fischer, Nastassja L; Souza, Wanderson F; Coutinho, Evandro Da Silva F; Vila, Jaime; Gleiser, Sonia; Figueira, Ivan; Volchan, Eliane

    2013-07-01

    The body's adaptive reaction to a stressful event, an allostatic response, involves vigorous physiological engagement with and efficient recovery from stress. Our aim was to investigate the influence of individual predispositions on cardiac responses to and recovery from a standardized psychosocial stress task (Trier Social Stress Task) in peacekeepers. We hypothesized that those individuals with higher trait resilience and those with higher resting vagal control would be more likely to present an allostatic response: a vigorous cardiac response to stress (i.e., reduction in interbeat intervals and heart rate variability (HRV)) coupled with a significant cardiac recovery in the aftermath. Fifty male military personnel with a mean age of 25.4 years (SD ± 5.99) were evaluated after returning from a peacekeeping mission. Electrocardiogram recordings were made throughout the experimental session, which consisted five conditions: basal, speech preparation, speech delivery, arithmetic task, and recovery. Mean interbeat intervals and HRV were calculated for each condition. An Ego-Resilience Scale and resting vagal control assessed individual predispositions. Stress tasks reduced interbeat intervals (tachycardia) and HRV in comparison with basal, with return to basal in the aftermath (p peacekeepers showing higher trait resilience and those with higher resting vagal control presented a more adaptive allostatic reaction characterized by vigorous cardiac response to stress (i.e., tachycardia and vagal withdrawal) and efficient cardiac recovery after stress cessation. PMID:23327672

  3. The effects of muscle exercise and bed rest on [18F]methylcholine PET/CT

    International Nuclear Information System (INIS)

    This study evaluated the impact of limited and strenuous physical exercise on [18F]methylcholine uptake in muscle. Ten consecutive patients participated, three of whom had strict bed rest, three were allowed to walk around and four performed strenuous single arm exercise by lifting a 7.5-kg weight. [18F]Methylcholine uptake was measured in the biceps and gluteus muscles on both sides. Strenuous exercise resulted in a 202% increase in [18F]methylcholine uptake in the activated biceps muscle as well as a 112% increase in muscle groups used to retain body position. This resulted in asymmetrical images that were visually less easy to interpret. In walking patients there was a more limited increase in biceps (45%) and gluteus (74%) muscle uptake, without visually recognizable differences. Strenuous exercise may result in a considerable increase in [18F]methylcholine uptake in muscle and should be avoided prior to imaging. Strict bed rest does not seem to be required. Tracer injection while resting on the scanner remains a safe approach. (orig.)

  4. The Semantic Network at Work and Rest: Differential Connectivity of Anterior Temporal Lobe Subregions

    Science.gov (United States)

    Jackson, Rebecca L.; Hoffman, Paul; Pobric, Gorana

    2016-01-01

    The anterior temporal lobe (ATL) makes a critical contribution to semantic cognition. However, the functional connectivity of the ATL and the functional network underlying semantic cognition has not been elucidated. In addition, subregions of the ATL have distinct functional properties and thus the potential differential connectivity between these subregions requires investigation. We explored these aims using both resting-state and active semantic task data in humans in combination with a dual-echo gradient echo planar imaging (EPI) paradigm designed to ensure signal throughout the ATL. In the resting-state analysis, the ventral ATL (vATL) and anterior middle temporal gyrus (MTG) were shown to connect to areas responsible for multimodal semantic cognition, including bilateral ATL, inferior frontal gyrus, medial prefrontal cortex, angular gyrus, posterior MTG, and medial temporal lobes. In contrast, the anterior superior temporal gyrus (STG)/superior temporal sulcus was connected to a distinct set of auditory and language-related areas, including bilateral STG, precentral and postcentral gyri, supplementary motor area, supramarginal gyrus, posterior temporal cortex, and inferior and middle frontal gyri. Complementary analyses of functional connectivity during an active semantic task were performed using a psychophysiological interaction (PPI) analysis. The PPI analysis highlighted the same semantic regions suggesting a core semantic network active during rest and task states. This supports the necessity for semantic cognition in internal processes occurring during rest. The PPI analysis showed additional connectivity of the vATL to regions of occipital and frontal cortex. These areas strongly overlap with regions found to be sensitive to executively demanding, controlled semantic processing. SIGNIFICANCE STATEMENT Previous studies have shown that semantic cognition depends on subregions of the anterior temporal lobe (ATL). However, the network of regions

  5. Inspiratory loading and limb blood flow in COPD: The modulating effects of resting lung hyperinflation.

    Science.gov (United States)

    Berton, Danilo C; de Castro, Marina A; Merola, Pietro; Benedetto, Igor; Castilho, Mariah; Vieira, Paulo J C; Knorst, Marli M; Neder, J Alberto

    2016-07-01

    Inspiratory resistive loading (IRL) may have deleterious cardiocirculatory effects leading to poor peripheral perfusion in severely-hyperinflated patients with COPD. Nineteen patients (13 severely-hyperinflated with inspiratory capacity/total lung capacity ratio≤0.28) underwent calf blood flow (CBF) measurements by venous occlusion plethysmography at rest and during IRL at 60% maximal inspiratory pressure. Severely-hyperinflated patients had lower resting CBF and greater calf vascular resistance (CVR) than moderately-hyperinflated patients (phyperinflated patients had markedly reduced CBF (p=0.01). Opposite to our main hypothesis, however, IRL did not further reduce CBF in these patients (p>0.05). Conversely, it significantly decreased CBF and increased CVR in moderately-hyperinflated patients; in fact, end-trial CBF and CVR did not differ between the groups (p>0.05). In conclusion, marked impairments in resting appendicular blood flow in severely-hyperinflated patients with COPD were seen only after acute IRL in less hyperinflated patients. These findings set the stage for studies investigating the effects of lung deflation on peripheral hemodynamics in patients with severe hyperinflation. PMID:26965088

  6. Effect of Air Outlet Angle on Air Distribution Performance Index

    Directory of Open Access Journals (Sweden)

    Isbeyeh W. Maid

    2013-05-01

    Full Text Available       In this paper a numerical study of velocity and temperature distribution in air conditioned space have been made. The computational model consists of the non-isothermal 3-D turbulent with (k-ε model. The numerical study is made to conduct air distribution in a room air-conditioned space with real interior dimensions (6×4×3m and to analyze the effect of changing angle of grille vanes on the flow pattern, velocity, and temperature distribution in the room under a set of different condition, and under a supply air temperature of 16˚C to examine the final result on air distribution performance index (ADPI.The results show a significant effect within the change of supply air angle, the maximum air distribution performance index (ADPI is 52% when air change per hour (ACH is equal to 10 at 16˚C inlet temperature with angle ( 15˚ down, and the minimum value of (ADPI is 20% when ACH is equal to 15 at 16˚C inlet temperature and angle ( degree. 

  7. Installation of NA62 Large Angle Veto detectors

    CERN Multimedia

    2012-01-01

    In May 2012, the NA62 collaboration has installed the first eight (out of 12) Large Angle Veto detectors for the accurate identification of photons. These subdetectors will re-use 3000 lead glass crystals with attached photomultipliers from the OPAL experiment at LEP – CERN’s former accelerator.

  8. Pitch angle distributions of energetic ions in the lobes of the distant geomagnetic tail

    International Nuclear Information System (INIS)

    Analysis of energetic (> 35 keV) ion data from the ISEE-3 spacecraft obtained during 1982-1983, when the spacecraft made a series of traversals of the distant geomagnetic tail (XGSE > - 230 RE), indicates that the pitch angle distribution of energetic ions in the distant tail lobes is usually highly anisotropic, being peaked closely perpendicular to the magnetic field direction, but with a small net flow in the antisunward direction. In this paper we present a model, based on the motion of single particles into and within the tail lobes, which accounts for these observed distributions. This model assumes that the lobe ions originate in the magnetosheath, where the energetic ion population consists of two components; a spatially uniform ''solar'' population, and a population of ''terrestrial'' origin, which decreases in strength with downtail distance. The pitch angle distribution at any point within the lobe may be constructed, assuming that the value of the distribution function along the particle trajectory is conserved. In general, those ions with a large field-aligned component to their motion enter the lobes in the deep tail, where the ''terrestrial'' source is weak, whilst those moving closely perpendicular to the field enter the lobes at positions much closer to the Earth, where the source is strong. The fluxes of these latter ions are therefore much enhanced above the rest of the pitch angle distribution, and are shown to account for the form of the observed distributions. The model also accounts for the more isotropic ion population observed in the lobe during solar particle events, when the ''terrestrial'' component of the magnetosheath source may be considered negligible in comparison to the enhanced ''solar'' component. (author)

  9. Reflectivity Model of Low Grazing Angle Radar Sea Clutter

    Institute of Scientific and Technical Information of China (English)

    FENG Sheng; CHEN Jie; CAI Tao; TU Xu-yan

    2005-01-01

    The commonly used reflectivity models of radar sea clutter are summarized. Among these models, the adjusted Barton model and the adjusted Morchin model are compared. From the analysis result, the γ-p reflectivity model is presented for low grazing angle radar sea clutter by the adjustment of the original Barton reflectivity model. The model takes into account radar frequency, grazing angle, sea condition, and polarization property. The influences of these factors on the proposed model are analyzed. The model absorbs the merits from commonly used reflectivity models for sea clutter. It introduces several researchers' opinions, and extends them. And it accounts for the reflectivity at arbitrary radar frequency from VHF to X-band, arbitrary low grazing angle, arbitrary sea condition and different polarization property. One of the main results is the proposed γ-p reflectivity model can reflect the influence of polarization on sea clutter reflectivity to some extent. The proposed γ-p reflectivity model of low-angle radar-sea clutter is validated by comparing the simulated and statistically experimental data.

  10. Multiple small-angle neutron scattering studies of anisotropic materials

    CERN Document Server

    Allen, A J; Long, G G; Ilavsky, J

    2002-01-01

    Building on previous work that considered spherical scatterers and randomly oriented spheroidal scatterers, we describe a multiple small-angle neutron scattering (MSANS) analysis for nonrandomly oriented spheroids. We illustrate this with studies of the multi-component void morphologies found in plasma-spray thermal barrier coatings. (orig.)

  11. Symmetry constraints for the emission angle dependence of HBT radii

    CERN Document Server

    Heinz, Ulrich W; Lisa, M A; Wiedemann, Urs Achim

    2002-01-01

    We discuss symmetry constraints on the azimuthal oscillations of two-particle correlation (Hanbury Brown--Twiss interferometry) radii for non-central collisions between equal spherical nuclei. We also propose a new method for correcting in a model-independent way the emission angle dependent correlation function for finite event plane resolution and angular binning effects.

  12. Identification of resting cells by dual-parameter flow cytometry of statin expression and DNA content

    Energy Technology Data Exchange (ETDEWEB)

    Pellicciari, C.; Mangiarotti, R.; Bottone, M.G.; Danova, M. [Univ. of Pavia (Italy); Wang, E. [Jewish General Hospital, Montreal, Quebec (Canada)

    1995-12-01

    Statin, a 57-kDa nuclear protein, has been recognized as a unique marker of quiescent (G{sub 0}) cells; specific monoclonal antibodies (MoAb) against statin have been produced and used to label resting cells in tissue sections and in cultured cells. We present an improved method for the identification of G{sub 0} cells by dual-parameter flow cytometry of statin expression and DNA content. The appropriate technical conditions were set up by using resting and cycling human fibroblasts as a model cell system. Several fixatives proved to be suitable for the immunocytochemical detection of statin; among them, 70% ethanol was selected because this fixation procedure is suitable for DNA staining with intercalating dyes and is routinely used for the immunolabeling of proliferation markers (such as proliferating cell nuclear antigen [PCNA] and Ki-67) and of bromodeoxyuridine (BrdUrd) incorporation. Following cell permeabilization with detergent, exposure to the antistatin antibody (S-44), and indirect fluorescein isothiocyanate immunolabeling, cells were counterstained for DNA with propidium iodide and analyzed by dual-parameter flow cytometry. In cells from several animal sources (rat thymocytes and C6 glioma cells, mouse 3T3 cells, and human MCF-7 cells), under different experimental conditions, the expression of statin was found to correlate inversely with that of PCNA and Ki-67, and with the BrdUrd labeling index. In dual-parameter flow scattergrams, G{sub 0} (statin positive) cells can be discriminated from the potentially cycling (statin negative) G{sub 1} cells, i.e., within a cell fraction having the same DNA content. This approach can be envisaged as a powerful tool both for monitoring changes in the resting cell fraction and for investigating the process of G{sub 0}-G{sub 1} transition in unperturbed and drug-treated cell populations. 48 refs., 5 figs., 1 tab.

  13. Lactobionic and cellobionic acid production profiles of the resting cells of acetic acid bacteria.

    Science.gov (United States)

    Kiryu, Takaaki; Kiso, Taro; Nakano, Hirofumi; Murakami, Hiromi

    2015-01-01

    Lactobionic acid was produced by acetic acid bacteria to oxidize lactose. Gluconobacter spp. and Gluconacetobacter spp. showed higher lactose-oxidizing activities than Acetobacter spp. Gluconobacter frateurii NBRC3285 produced the highest amount of lactobionic acid per cell, among the strains tested. This bacterium assimilated neither lactose nor lactobionic acid. At high lactose concentration (30%), resting cells of the bacterium showed sufficient oxidizing activity for efficient production of lactobionic acid. These properties may contribute to industrial production of lactobionic acid by the bacterium. The bacterium showed higher oxidizing activity on cellobiose than that on lactose and produced cellobionic acid. PMID:25965080

  14. Custom optimisation of wedge angles in prostate radiotherapy

    International Nuclear Information System (INIS)

    A method for computing optimised wedge angles will be presented along with a performance evaluation over 12 patients with early prostate cancer. The method (an optimisation algorithm) was applied to standard 3 field treatment plans for each patient. The optimisation algorithm was based on simulated anealing using an efficient dose based cost function. The algorithm has been run in three PLAN MODES: (1) where the wedge angles were fixed by the human planner and only the beam-weights were optimised; (2) where both the wedge angles and beam-weights were optimised; and (3) where both the wedge angles and beam-weights were optimised and a non-uniform dose was prescribed to the PTV. In the latter PLAN MODE, a uniform 100% dose was prescribed to all of the PTV except for that region that overlaps with the rectum where a lower (e.g. 90%) dose was prescribed. The resulting optimised plans have been compared with those of the human planner who found beam-weights by conventional forward planning. Plans were compared on the basis of dose statistics, normal-tissue-complication-probability (NTCP) and tumour-control-probability (TCP). The results show that all 3 PLAN MODES produced plans with slightly higher TCP for the same rectal NTCP, than the human planner. The best results were observed for PLAN MODE 3, where a non-uniform PTV dose was prescribed. An average increase in TCP of 0.73% (± 0.20 95% confidence interval) is predicted. Probably the most significant benefit of the algorithm in the prostate setting is the time saved (about a factor of 10) in computing optimised beam-weights and wedge angles for this simple plan

  15. CHARACTERIZATION OF POWDER FLOWABILITY USING MEASUREMENT OF ANGLE OF REPOSE

    Institute of Scientific and Technical Information of China (English)

    D.; Geldart; E.; C.; Abdullah; A.; Hassanpour; L.; C.; Nwoke; I.; Wouters

    2006-01-01

    In response to the need in industry for a quick and reproducible method of measuring the flowability of powders in processes involving transport and storage, the apparently simple idea of measuring angle of repose has been revived. The simple tester first used has evolved over a number of years into the present version which is shown to be capable of handling quite small samples of powders that are even slightly cohesive. Experimental data are presented and results shown to compare consistently with the better known Hausner ratio.

  16. Absorption of negative pions resting on nuclei of the 1p layer. Theoretical and experimental aspects

    International Nuclear Information System (INIS)

    As the probability of capture of π- resting on 12C with emission of a single proton which has been measured on the Saclay Linear Accelerator (ALS), is relatively high, it was obvious that this reaction type was based on a mechanism involving two nucleons. Due to the lack of theoretical interpretation for the emission of a single nucleon, a model has been developed in which the pion is absorbed by a correlated proton-proton pair, only one of these both protons being emitted. The first part of this research thesis addresses the calculation of absorption on a pair of nucleons with emission of these nucleons. It comprises the detailed presentation of the theoretical model, its comparison with other published calculations, and the comparison with results obtained by experiments of emission of nucleon pairs from carbon and oxygen. The second part proposes an overview of the great number of experimental results obtained by capture of π- resting on carbon. It reports the measurement of the emission of a single nucleon, the presentation of the elaborated theoretical model which has been developed to interpret this measurement. The author also compares the results of his calculation with the experimentally measured probability for the (π-p) process and the results published on the measurement of the (π-n).reaction

  17. Small angle neutron scattering and small angle X-ray scattering studies of platinum-loaded carbon foams

    Indian Academy of Sciences (India)

    P U Sastry; V K Aswal; A G Wagh

    2008-11-01

    The morphology of carbon nanofoam samples comprising platinum nanoparticles dispersed in the matrix was characterized by small angle neutron scattering (SANS) and small angle X-ray scattering (SAXS) techniques. Results show that the structure of pores of carbon matrix exhibits a mass (pore) fractal nature and the average radius of the platinum particles is about 2.5 nm. The fractal dimension as well as the size distribution parameters of platinum particles varies markedly with the platinum content and annealing temperature. Transmission electron micrographs of the samples corroborate the SANS and SAXS results.

  18. Thallium-201 peripheral perfusion scans: feasibility of single-dose, single-day, rest and stress study

    International Nuclear Information System (INIS)

    The distribution and redistribution kinetics of thallium-201 in the lower extremities were investigated to determine the relationships among the rest, stress, and delayed-stress perfusion studies. The distribution of perfusion when the tracer was administered at rest was compared with that when administered during stress, and the distribution 5 to 6 h after the stress injection. In nine of 10 subjects without peripheral vascular disease, the 5 to 6 h poststress redistribution pattern was unchanged from the stress pattern and was different from the rest pattern. However, in all patients with peripheral vascular disease, the delayed poststress perfusion distribution had greater similarity to the rest pattern and was substantially different from that noted immediately after stress. Using the time frame of this study, the stress and delayed-stress 201Tl perfusion study of the lower extremities cannot be used to represent true rest perfusion. However, because of the similarity of the delayed-stress to the true rest distribution in abnormals, it may be clinically useful in defining rest and stress alterations

  19. The Oncogenic STP Axis Promotes Triple-Negative Breast Cancer via Degradation of the REST Tumor Suppressor

    Directory of Open Access Journals (Sweden)

    Kristen L. Karlin

    2014-11-01

    Full Text Available Defining the molecular networks that drive breast cancer has led to therapeutic interventions and improved patient survival. However, the aggressive triple-negative breast cancer subtype (TNBC remains recalcitrant to targeted therapies because its molecular etiology is poorly defined. In this study, we used a forward genetic screen to discover an oncogenic network driving human TNBC. SCYL1, TEX14, and PLK1 (“STP axis” cooperatively trigger degradation of the REST tumor suppressor protein, a frequent event in human TNBC. The STP axis induces REST degradation by phosphorylating a conserved REST phospho-degron and bridging REST interaction with the ubiquitin-ligase βTRCP. Inhibition of the STP axis leads to increased REST protein levels and impairs TNBC transformation, tumor progression, and metastasis. Expression of the STP axis correlates with low REST protein levels in human TNBCs and poor clinical outcome for TNBC patients. Our findings demonstrate that the STP-REST axis is a molecular driver of human TNBC.

  20. Use of lower body negative pressure to counter symptoms of orthostatic intolerance in patients, bed rest subjects, and astronauts

    Science.gov (United States)

    Lathers, C. M.; Charles, J. B.

    1993-01-01

    This report briefly discusses some aspects of autonomic cardiovascular dysfunction as related to changes in orthostatic function in patients, bed rest subjects, and astronauts. This relationship is described in normal individuals to provide the basis for discussion of parameters that may be altered in patients, bed rest subjects, and astronauts. The relationships between disease states, age, periods of weightlessness during space flight, and autonomic dysfunction, and their contribution to changes in orthostatic tolerance are presented. The physiologic effects of lower body negative pressure are illustrated by presenting data obtained in bed rest subjects and in astronauts. Finally, the usefulness of lower body negative pressure to counter symptoms of orthostatic intolerance in patients, bed rest subjects, and astronauts is discussed.

  1. Changes of concave and convex rib-vertebral angle, angle difference and angle ratio in patients with right thoracic adolescent idiopathic scoliosis.

    Science.gov (United States)

    Canavese, Federico; Turcot, Katia; Holveck, Jerôme; Farhoumand, Agnés Dahl; Kaelin, André

    2011-01-01

    The aim of this study is to describe the radiological changes in rib-vertebral angles (RVAs), rib-vertebral angle differences (RVADs), and rib-vertebral angle ratios (RVARas) in patients with untreated right thoracic adolescent idiopathic scoliosis and to compare with the normal subjects. The concave and convex RVA from T1 to T12, the RVADs and the RVARas were measured on AP digital radiographs of 44 female patients with right convex idiopathic scoliosis and 14 normal females. Patients were divided into three groups: normal subjects (group 1), scoliotic patients with Cobb's angle equal or <30° (group 2) and scoliotic patients with Cobb's angle over 30° (group 3). Overall values (mean ± SD) of the RVAs on the concave side were 90.5° ± 17° in group 1, 90.3° ± 15.8° in group 2 and 88.8° ± 15.4° in group 3. On the convex side, values were 90.0° ± 17.3° in group 1, 86.3° ± 13.7° in group 2 and 80.7° ± 14.4° in group 3. Overall values (mean ± SD) of the RVADs at all levels were 0.5° ± 0.7° in group 1, 4.0° ± 4.8° in group 2 and 8.0° ± 4.0° in group 3. The RVARa values (mean ± SD) at all levels was 1.008° ± 0.012° in group 1, 1.041° ± 0.061° in group 2 and 1.102° ± 0.151° in group 3. RVAD and RVARa values in the scoliotic segment were greater in patients with untreated scoliosis over 30° than in patients with an untreated deformity of <30° or normal subjects. A significant effect between groups was observed for the RVA, RVAD and RVARa variables. Measurement of RVA, RVAD and RVARa should not only be performed at and around the apex of a thoracic spinal deformity, but also extended to the whole thoracic spine. PMID:20811755

  2. Resting behaviour of Anopheles stephensi type form to assess its amenability to control malaria through indoor residual spray

    Directory of Open Access Journals (Sweden)

    B.N. Nagpal, Aruna Srivastava & A.P. Dash

    2012-09-01

    Full Text Available Background & objectives: In the present study, an attempt was made to find reasons of ineffectiveness of indoorresidual spray to interrupt malaria transmission by investigating the behaviour of two variants of Anophelesstepnesi, viz. type form and mysorensis in rural areas of Rajasthan, India.Methods: Both low malarious (DDT spray from 1958 to 1976 and high malarious (DDT spray from 1958 to April2006 villages were selected for the study in Arid zone district Jodhpur, Rajasthan during March–April 2006.Resting behaviour of the species during all its movement rhythms covering 24 h period related to: (i swarming/mating; (ii pre- and post-biting rest; (iii after feed resting between hoping movements; (iv night and day timeresting and; (v diel activity movements in response to temperature changes, were carried out.Results: The results showed that household objects like cupboards, furnitures, hanging clothes, goods stacked onloft, stored clothes, cobwebs and floor were the dominant resting sites both in sprayed and unsprayed villages.About 95 and 97% of An. stephensi preferred to rest on household objects of unsprayed and sprayed villagesrespectively. There was no significant difference in resting behaviour of the species in both groups of villages(p >0.05. The pre-biting resting time was recorded as 5 to 15 min whereas post-biting resting time lasted for 15 to25 min. After biting outdoor (in courtyard – open to sky species starts entering the rooms at around 2330 hrs. Itwas observed that during III quarter (0100 to 0400 hrs maximum species entered into the room were 56% inunsprayed and 62% in sprayed villages. Statistically there was no significant difference in the entry of mosquitoes(p >0.05 in both the groups of villages.Conclusion: Before DDT era, An. stephensi was found resting at all heights of the walls inside the human dwellings.Present study revealed that An. stephensi is trying to avoid sprayable surfaces and tend to rest on

  3. Bio-transformation of Glycerol to 3-Hydroxypropionic Acid Using Resting Cells of Lactobacillus reuteri.

    Science.gov (United States)

    Ramakrishnan, Gopi Gopal; Nehru, Ganesh; Suppuram, Pandiaraj; Balasubramaniyam, Sowmiya; Gulab, Brajesh Raman; Subramanian, Ramalingam

    2015-10-01

    Lactobacillus reuteri grown in MRS broth containing 20 mM glycerol exhibits 3.7-fold up-regulation of 3-hydroxypropionic acid (3-HP) pathway genes during the stationary phase. Concomitantly, the resting cells prepared from stationary phase show enhancement in bio-conversion of glycerol, and the maximum specific productivity (q p) is found to be 0.17 g 3-HP per g CDW per hour. The regulatory elements such as catabolite repression site in the up-stream of 3-HP pathway genes are presumed for the augmentation of glycerol bio-conversion selectively in stationary phase. However, in the repression mutant, the maximum q p of 3-HP persisted in the stationary phase-derived resting cells indicating the role of further regulatory features. In the production stage, the external 3-HP concentration of 35 mM inhibits 3-HP synthesis. In addition, it has also moderated 1,3-propanediol formation, as it is a redox bio-catalysis involving NAD(+)/NADH ratio of 6.5. Repeated batch bio-transformation has been used to overcome product inhibition, and the total yield (Ypx) of 3-HP from the stationary phase-derived biomass is 3.3 times higher than that from the non-repeated mode. With the use of appropriate gene expression condition and repeated transfer of biomass, 3-HP produced in this study can be used for low-volume, high-value applications. PMID:26204968

  4. Mandibular Angle Fractures: Comparison of One Miniplate vs. Two Miniplates

    Directory of Open Access Journals (Sweden)

    Saeed Hajmohammadi

    2013-01-01

    Full Text Available Background: Monocortical miniplate fixation is an accepted and reliable method for internal fixation of mandibular angle fractures. Although placement of a second miniplate may theoretically provide more stability; however, the clinical importance of this issue remains controversial.Objectives: The present study assessed the postoperative complications and outcomes associated with the fixation of mandibular angle fractures using 1 and 2 miniplates in patients with favorable mandibular angle fractures.Patients and Methods: A prospective study of 87 patients (73 males, 14 females with favorable mandibular angle fractures was done. In the first group, a 4-hole miniplate was placed at the superior border through an intraoral approach. In group 2, patients were treated with 2 miniplates, one placed at the superior border (similar to group 1 and the other on the lateral aspect of the angle at the inferior border through an intraoral and transcutaneous approach using a trocar. Postoperative complications including malocclusion, malunion and sensory disturbances associated with surgery, additional maxillomandibular fixation (MMF by means of an arch bar and wires for a longer period (for delayed union and infection were assessed in patients of both groups up to 12 months postoperatively. The data were analyzed using the chi-square test.Results: In the single miniplate group, 25 patients showed lip numbness associated with surgery (55.6%, 22 patients required additional use of MMF (48.9% and 3 patients developed infections (6.7%. In the double miniplate group 20 patients showed lip numbness associated with surgery (47.6%, 18 patients required additional use of MMF (42.9% and 1 patient developed infection (2.4%. None of the patients in either group showed malocclusion or malunion. No significant difference was observed between the groups regarding overall complication rate.Conclusions: In this study, use of one miniplate or two miniplates for treatment of

  5. Effectiveness of Comprehensive Nursing Care Relieving Problems of Hospitalized High-Risk Pregnant Women in Bed Rest

    OpenAIRE

    Umran Yesiltepe Oskay; Anahit Coskun

    2012-01-01

    It is well known that bed rest at home or in hospital has many physical and psychosocial effects on pregnant women. Objective: This study is type of an intervention study which has been conducted to determine bed rest related physical and psychosocial problems of hospitalized high-risk pregnant women and effectiveness of a comprehensive nursing care plan in solving to those problems. Material and Method: The sample group was selected among high-risk pregnant women who were hospitalized in per...

  6. Vagal modulation of resting heart rate in rats: the role of stress, psychosocial factors and physical exercise

    OpenAIRE

    Luca eCarnevali; Andrea eSgoifo

    2014-01-01

    In humans, there are large individual differences in the levels of vagal modulation of resting heart rate. High levels are a recognized index of cardiac health, whereas low levels are considered an important risk factor for cardiovascular morbidity and mortality. Several factors are thought to contribute significantly to this inter-individual variability. While regular physical exercise seems to induce an increase in resting vagal tone, chronic life stress and psychosocial factors such as neg...

  7. Data on the impact of SSRIs and depression symptoms on the neural activities in obsessive-compulsive disorder at rest.

    Science.gov (United States)

    Chen, Yunhui; Juhas, Michal; Greenshaw, Andrew J; Hu, Qiang; Meng, Xin; Cui, Hongsheng; Ding, Yongzhuo; Kang, Lu; Zhang, Yubo; Wang, Yuhua; Cui, Guangcheng; Li, Ping

    2016-09-01

    The data provided here related to our research article (Chen et al., 2016) [1]. We provide whole-brain intrinsic functional connectivity patterns in obsessive-compulsive disorder at resting-state [1]. This article also provides supplementary information to our research article, i.e., between - group comparisons of the effect of selective serotonin reuptake inhibitors (SSRIs) and combined depression symptoms on resting-state neural activities in obsessive-compulsive disorder. The data presented here provide novel insights into the effect of SSRIs and combined depression symptoms on the neural activities at rest. PMID:27504477

  8. Free vibration analysis of magnetoelectroelastic plate resting on a Pasternak foundation

    International Nuclear Information System (INIS)

    Free vibration of a magnetoelectroelastic plate resting on a Pasternak foundation is investigated based on Mindlin theory. The in-plane electric and magnetic fields can be ignored for plates. According to the Maxwell equation and magnetoelectric boundary condition, the variation of electric and magnetic potentials along the thickness direction of the plate is determined. Using Hamilton’s principle, the governing equations of motion for the magnetoelectroelastic plate are derived. Numerical results reveal the effects of the electric and magnetic potentials, spring and shear coefficients of the Pasternak foundation on the vibration frequency. These results may be useful in the analysis and design of smart structures constructed from magnetoelectroelastic materials. (paper)

  9. Quantification of projection angle in fragment generator warhead

    Directory of Open Access Journals (Sweden)

    K.D. Dhote

    2014-06-01

    Full Text Available Tactical Ballistic Missile (TBM class target neutralization by the fragment spray of a Fragment Generator Warhead (FGW calls for quantification of fragment projection angle scatter to finalize the end game engagement logic. For conventional axi-symmetric warhead, dispersion is assumed to be normal with a standard deviation of 30. However, such information is not available in case of FGW. Hence, a set of experiments are conducted to determine the dispersion of fragments. The experiments are conducted with a specific configuration of FGW in an identical arena to quantify the scatter and then verified its applicability to other configurations having a range of L/D and C/M ratios, and contoured fragmenting discs. From the experimental study, it is concluded that the scatter in projection angle follows normal distribution with a standard deviation of 0.75° at Chi-square significance level of 0.01(χ20.99.

  10. The mean visible labial length of maxillary and mandibular anterior teeth at rest

    International Nuclear Information System (INIS)

    To determine the mean visible labial length of maxillary and mandibular anterior teeth at rest. Study Design: Cross-sectional study. Place and Duration of Study: Department of Prosthodontics, Dr. Ishrat-ul-Ebad Khan Institute of Oral Health Sciences, Karachi, from October 2012 to March 2013. Methodology: A total of 200 subjects were included. Measurements were carried out using digital caliper from the border of the lip to the incisal edges of incisor and to the cusp tip for the canines. The length of the upper lip was measured from subnasale to stomion. Statistical analyses were performed by Mann Whitney-U test and Kruskal Walli's test. Results: The age of the participant ranged between 20 and 65 years. At rest, females significantly displayed more of the maxillary central incisor (2.93 +- 1.57 mm; p=0.003), lateral incisor (1.87 +- 1.12 mm; p=0.005) and canine (0.59 +- 0.62 mm; p=0.031). With increasing age, the amount of maxillary anterior teeth visible at rest significantly decreased (p < 0.001), and increased for the mandibular teeth (p < 0.001). Subjects with shorter upper lips significantly displayed more maxillary anterior incisor structure than subjects with longer upper lip (p < 0.001). Conclusion: Females displayed significantly more labial length of the maxillary anterior teeth. The mean visible labial length of maxillary anterior teeth significantly decreased with increasing age and increased for the mandibular teeth. As the upper lip length increased, the mean visible labial length of maxillary anterior teeth significantly decreased. (author)

  11. Buckling Analysis of Rectangular Plates with Variable Thickness Resting on Elastic Foundation

    International Nuclear Information System (INIS)

    Buckling of rectangular plates of variable thickness resting in elastic foundation is analysed using a quintic spline approximation technique. The thickness of the plate varies in the direction of one edge and the variations are assumed to be linear, exponential and sinusoidal. The plate is subjected to in plane load of two opposite edges. The buckling load and the mode shapes of buckling are computed from the eigenvalue problem that arises. Detailed parametric studies are made with different boundary conditions and the results are presented through the diagram and discussed

  12. Long range stress correlations in the inherent structures of liquids at rest

    Science.gov (United States)

    Chowdhury, Sadrul; Abraham, Sneha; Hudson, Toby; Harrowell, Peter

    2016-03-01

    Simulation studies of the atomic shear stress in the local potential energy minima (inherent structures) are reported for binary liquid mixtures in 2D and 3D. These inherent structure stresses are fundamental to slow stress relaxation and high viscosity in supercooled liquids. We find that the atomic shear stress in the inherent structures (IS's) of both liquids at rest exhibits slowly decaying anisotropic correlations. We show that the stress correlations contribute significantly to the variance of the total shear stress of the IS configurations and consider the origins of the anisotropy and spatial extent of the stress correlations.

  13. Increased rate of whole body lipolysis before and after 9 days of bed rest in healthy young men born with low birth weight

    DEFF Research Database (Denmark)

    Alibegovic, Amra Ciric; Hojbjerre, Lise; Sonne, Mette;

    2010-01-01

    activity in both groups. All subjects developed peripheral insulin resistance in response to bed rest (all P hepatic insulin resistance in response to bed rest. Conclusions: Increased WBL may contribute to the development of hepatic...

  14. Impact of drive hunts on daytime resting site areas of wild boar family groups (Sus scrofa L.

    Directory of Open Access Journals (Sweden)

    Pohlmeyer, K.

    2007-06-01

    Full Text Available The population density of wild boar in Lower Saxony, Germany has increased enormously in the last decades. Therefore, it is crucial to reduce the density by hunting the wild boar, especially in zones of Classical Swine Fever disease (CSF. The drive hunt, which is an effective hunting method, forces wild boars to leave their daily resting sites. However, this hunting method increases the risk of animals spreading over a wider area, which leads to a greater risk of infecting other individuals with the CSF-virus.Behavioural data of nine radio-marked wild boar family groups (corresponding to ten observations and their habitat use was analysed by telemetry. Particular attention was given to the effects of drive hunting on the selection of daytime resting sites before and after a drive hunt. On average the daytime resting range size of the different groups covered 627 ha. The observation period lasted approximately eight weeks (four weeks before and after a drive hunt. The mean resting range area was 183 ha and it increased to 299 ha after the hunt. Six wild boar groups increased temporarily the size of their resting ranges after a hunt. Three of them moved up to 6 km outside their range. The groups left their forest stands and had to cross extensive coverless farmland. Four groups reduced their resting range size. On average, the family groups became active during the night after the drive hunts.

  15. Visualisation and identification of the interaction between STIM1s in resting cells.

    Directory of Open Access Journals (Sweden)

    Jun He

    Full Text Available Store-operated Ca(2+ channels are a major Ca(2+ entry pathway in nonexcitable cells, which drive various essential cellular functions. Recently, STIM1 and Orai proteins have been identified as the major molecular components of the Ca(2+ release-activated Ca(2+ (CRAC channel. As the key subunit of the CRAC channel, STIM1 is the ER Ca(2+ sensor and is essential for the recruitment and activation of Orai1. However, the mechanisms in transmission of information of STIM1 to Orai1 still need further investigation. Bimolecular fluorescence complementation (BiFC is one of the most advanced and powerful tools for studying and visualising protein-protein interactions in living cells. We utilised BiFC and acceptor photobleaching fluorescence resonance energy transfer (FRET experiments to visualise and determine the state of STIM1 in the living cells in resting state. Our results demonstrate that STIM1 exists in an oligomeric form in resting cells and that rather than the SAM motif, it is the C-terminus (residues 233-474 of STIM1 that is the key domain for the interaction between STIM1s. The STIM1 oligomers (BiFC-STIM1 and wild-type STIM1 colocalised and had a fibrillar distribution in resting conditions. Depletion of ER Ca(2+ stores induced BiFC-STIM1 distribution to become punctate, an effect that could be prevented or reversed by 2-APB. After depletion of the Ca(2+ stores, BiFC-STIM1 has the ability to form puncta that colocalise with wild-type STIM1 or Orai1 near the plasma membrane. Our data also indicate that the function of BiFC-STIM1 was not altered compared with that of wild-type STIM1.

  16. Incoherent photoproduction of pseudoscalar mesons off nuclei at forward angles

    CERN Document Server

    Gevorkyan, S; Gan, L; Larin, I; Khandaker, M

    2009-01-01

    Recent advances in the photon tagging facilities together with the novel, high resolution fast calorimetry made possible to perform photoproduction cross section measurements of pseudoscalar mesons on nuclei with a percent level accuracy. The extraction of the radiative decay widths, needed for testing the symmetry breaking effects in QCD, from these measurements at small angles is done by the Primakoff method. This method requires theoretical treatment of all processes participating in these reactions at the same percent level. The most updated description of general processes, including the nuclear coherent amplitude, is done in our previous paper. In this work, based on the framework of Glauber multiple scattering theory, we obtain analytical expressions for the incoherent cross section of the photoproduction of pseudoscalar mesons off nuclei accounting for the mesons absorption in nuclei and Pauli suppression at forward production angles. As illustrations of the obtained formulas, we calculate the incoher...

  17. Refractivity estimations from an angle-of-arrival spectrum

    Institute of Scientific and Technical Information of China (English)

    Zhao Xiao-Feng; Huang Si-Xun

    2011-01-01

    This paper addresses the probability of atmospheric refractivity estimation by using field measurements at an array of radio receivers in terms of angle-of-arrival spectrum. Angle-of-arrival spectrum information is simulated by the ray optics model and refractivity is expressed in the presence of an ideal tri-linear profile. The estimation of the refractivity is organized as an optimization problem and a genetic algorithm is used to search for the optimal solution from various trial refractivity profiles. Theoretical analysis demonstrates the feasibility of this method to retrieve the refractivity parameters. Simulation results indicate that this approach has a fair anti-noise ability and its accuracy performance is mainly dependent on the antenna aperture size and its positions.

  18. The Spectral Sharpness Angle of Gamma-ray Bursts

    CERN Document Server

    Yu, Hoi-Fung; Greiner, Jochen; Sari, Re'em; Bhat, P Narayana; von Kienlin, Andreas; Paciesas, William S; Preece, Robert D

    2016-01-01

    We explain the results of Yu et al. (2015b) of the novel sharpness angle measurement to a large number of spectra obtained from the Fermi gamma-ray burst monitor. The sharpness angle is compared to the values obtained from various representative emission models: blackbody, single-electron synchrotron, synchrotron emission from a Maxwellian or power-law electron distribution. It is found that more than 91% of the high temporally and spectrally resolved spectra are inconsistent with any kind of optically thin synchrotron emission model alone. It is also found that the limiting case, a single temperature Maxwellian synchrotron function, can only contribute up to 58+23 -18% of the peak flux. These results show that even the sharpest but non-realistic case, the single-electron synchrotron function, cannot explain a large fraction of the observed spectra. Since any combination of physically possible synchrotron spectra added together will always further broaden the spectrum, emission mechanisms other than optically...

  19. Dynamic contact angle of water-based titanium oxide nanofluid

    OpenAIRE

    Radiom, Milad; Yang, Chun; Chan, Weng Kong

    2013-01-01

    Abstract This paper presents an investigation into spreading dynamics and dynamic contact angle of TiO2-deionized water nanofluids. Two mechanisms of energy dissipation, (1) contact line friction and (2) wedge film viscosity, govern the dynamics of contact line motion. The primary stage of spreading has the contact line friction as the dominant dissipative mechanism. At the secondary stage of spreading, the wedge film viscosity is the dominant dissipative mechanism. A theoretical model based ...

  20. Oscillations of Relative Inclination Angles in Compact Extrasolar Planetary Systems

    OpenAIRE

    Becker, Juliette C.; Adams, Fred C.

    2015-01-01

    The Kepler Mission has detected dozens of compact planetary systems with more than four transiting planets. This sample provides a collection of close-packed planetary systems with relatively little spread in the inclination angles of the inferred orbits. A large fraction of the observational sample contains limited multiplicity, begging the question whether there is a true diversity of multi transiting systems, or if some systems merely possess high mutual inclinations, allowing them to appe...