WorldWideScience

Sample records for angiogenesis related publications

  1. Publicity and public relations

    Science.gov (United States)

    Fosha, Charles E.

    1990-01-01

    This paper addresses approaches to using publicity and public relations to meet the goals of the NASA Space Grant College. Methods universities and colleges can use to publicize space activities are presented.

  2. Public relations

    International Nuclear Information System (INIS)

    1998-01-01

    The Nuclear Regulatory Authority of the Slovak Republic (NRA SR) laid the foundation of a policy of keeping the public informed about the activities and the safety of nuclear installations in the SR already in its origins by opening the NRA Information Centre. The NRA SR issues the Bulletin on NRA SR for domestic and foreign use, the bilingual Annual report on NRA activities for domestic and foreign public - detailed report for the specialists and a version for the Slovak Republic state authorities. On the occasion of the anniversary of the IAEA a special publication on the IAEA was prepared. Forty-nine contributions on NRA national and foreign activities were trans-missed to the Press Agency of the SR (TASR) over the course of 1997. In the journal Safety of Nuclear Energy the column 'Information' periodically carries the briefs on NRA activities. Four essential articles on NRA mission and responsibility in the are of peaceful uses of atomic energy were published in the Newsletter of the Slovak Information Agency (SIA). Contributions on NRA activities and international co-operation are periodically put out in the 'Slovenske elektrarne' Newsletter, the Slovak Nuclear Society Bulletin. Report on the Safety of NPPs in the Slovak Republic is annually published in the Journal European Nuclear Society - Nuclear Europe Worldscan. Some articles on NRA activities were published in the world information agency NucNet. The NRA issued in 1997 four editions of the internal Bulletin on the NRA's national and foreign activities and personnel. Three press conferences were held and six events were arranged in radio broadcasting in 1997

  3. Public Relations and Marketing.

    Science.gov (United States)

    Savage, Daniel D.

    1987-01-01

    Urges community colleges to adopt pro-active public relations strategies. Examines the role of the public information officer in such areas as coordination of public relations and marketing activities, relations with media, and the development of a comprehensive public relations plan. (AYC)

  4. Public relations as public information

    Energy Technology Data Exchange (ETDEWEB)

    Coninx, C.

    1983-01-01

    To the man in the street, the topic of nuclear energy on the one hand is a highly emotional subject incorporating dangers hard to assess. However, on the other hand, there is in most cases little inclination to concern oneself with problems of energy economy. Public relations activities therefore frequently must motivate their adresses to accept information before they can actually inform. In this connection, the informing party must appear trustworthy and avoid that a teacher : pupil relationship is created. In addition, the changes in the socio-political environment must be taken into account. Within the industries and organizations engaged in the nuclear field there is the problem that the effects and the impact of public relations work can hardly be gaged by individually, which greatly hampers quantification of the work actually done.

  5. Her-2/neu overexpression is associated with thrombospondin-1-related angiogenesis and thrombospondin-1-unrelated lymphangiogenesis in breast cancer

    Directory of Open Access Journals (Sweden)

    Ming-Chuan Hong

    2013-11-01

    Conclusion: Our in vivo results showed that Her-2/neu affects the biological manifestations of breast cancer by increasing angiogenesis (which is TSP-1-related and lymphangiogenesis, which is TSP-1-unrelated.

  6. Strategi Komunikasi Public Relations

    OpenAIRE

    Artis, Artis

    2011-01-01

    Living man in interrelates society. Relationship among human being done by gets communication so man one by another one mutually understand and influence regard for the benefit, it that always been practiced by Public Relations( liaison) in a governance and also firm institute to reach to the effect which ices. The institute of Public Relations declares for,”Public Relations is overall effort which be passed off by design and berkesenambungan in order to creates and pet keenness and mutual un...

  7. Public acceptance and public relations

    International Nuclear Information System (INIS)

    Tanaka, Yasumasa

    1977-01-01

    A set of problems are discussed, which must be studied before the public relations are dealt with. Firstly, the trade-off between energy and health must be considered. There were several ages in which the consideration on health took preference to the energy requirement in the past. For example, the use of coal in London was prohibited by the King's proclamation in 1,306. Secondly, the selection for the acceptance of atomic power development and utilization is based on the subjective susceptibility psychologically, and cannot be concluded only by the logical reasoning. Thirdly, the strict definition of ''national consensus'' is necessary. That is, whether does it mean pleviscite or mere mood. Fourthly, whether the atomic energy is free from the danger or death biologically or not. Fifthly, is there any method for discriminating the persons who accept atomic power from the persons who do not socially. Although the probability of death caused by atomic accidents is very small (one three hundred millionth a year), many peoples hate atomic power and oppose to the construction of nuclear power plants. Four reasons for this are considered: (1) social diffusion of innovation, (2) nuclear allergy, (3) shortage of the conception of risk-benefit, and (4) heterogeneity of the public. According to the investigation of the relationship between electric power and livelihood, carried out by the policy and science research institute in Tokyo, the highly subjective decision for the acceptance of atomic power is independent of the objective knowledge on atomic power. (Iwakiri, K.)

  8. Public relations and ethics

    Directory of Open Access Journals (Sweden)

    Bajić Milan

    2010-01-01

    Full Text Available The aim of this paper is the analysis of different forms of PR implementation and research its relation with ethics in practice. 'Public relations' is the every-day term that represents the job that is widely used in all aspects of life and work in today's society. Public relations represent a specific form of communication that has a particular application in society. Public relations involve focusing on a public aspect of organization with the aim of building a positive attitude and image. Image of public relations as a profession is often unfairly negative, and the reason for this is unprofessional and unethical relation of individuals towards their profession. In practice ethics in public relations is often considered to be an oxymoron. Ethical thinking of experts in public relations goes from Biblical attitude 'all you want people to do to you, do even so to them' (Matthew 7:12to professional loyalty to organization they work for. Because of unethical appearance it is important to set the rules, in the form of codex by which the public relations professionals will set their behaviors. .

  9. Public Relations vs. Propaganda

    Directory of Open Access Journals (Sweden)

    Alexandru BASTIAN

    2006-10-01

    Full Text Available The paper aims at presenting the characteristics, methods and aplications of two related activities – Public Relations and propaganda. Although different from the piont of wiev of purpose and results (the practice of Public Relations aims at establishing and maintaining mutual lines of communications, understanding, acceptance, and cooperation between an organization and its publics, through transparency and honesty, while propaganda insists on a message that is intended primarily to serve the interests of the messenger. in order to influence public opinion and to manipulate other people’s beliefs by any means necessary, the two activities also present quite a lot of similarities.

  10. Functions of public relations

    Directory of Open Access Journals (Sweden)

    Baranov G. V.

    2016-09-01

    Full Text Available the article reveals the importance of communication with the public in the implementation of human rights and the ideals of mankind; characterized by the specificity of public relations in the information culture of belief; PR functions are explained on the criterion of optimization of activity of social interactions on the basis of cultural ideals.

  11. Argumentation and Public Relations.

    Science.gov (United States)

    Stovall, Richard L.

    Issue management oriented public relations provides an excellent pedagogical device for anyone interested in the application of argumentation. This can be illustrated by a case study in which a commercial metals company was wrongly accused of improperly disposing of toxic waste at a particular site. To counter the bad publicity that followed the…

  12. Public Relations Strategies for Scholastic Publication Staffs.

    Science.gov (United States)

    Konkle, Bruce E.

    2000-01-01

    Discusses the importance to scholastic publications staffs of four public relations strategies: meticulous research, systematic planning, strengthening communication efforts, and evaluation. Notes internal and external factors crucial to good public relations. Lists activities to consider. (SR)

  13. STRATEGI KOMUNIKASI PUBLIC RELATIONS

    Directory of Open Access Journals (Sweden)

    Artis Artis

    2011-11-01

    Full Text Available Living man in interrelates society. Relationship among human being done by gets communication so man one by another one mutually understand and influence regard for the benefit, it that always been practiced by Public Relations( liaison in a governance and also firm institute to reach to the effect which ices. The institute of Public Relations declares for,”Public Relations is overall effort which be passed off by design and berkesenambungan in order to creates and pet keenness and mutual understanding among an organization with whole its member “. In this case, Public Relations in give distribution on manajement's strategy there is two: First, Doing task as part of Public Relations's strategy and involvement in comprehensive process and gives benefit for management an organization. Both of, Public Relations gets role in management strategy in bring off activity to reach to the effect good one gets internal character and also external one correspond to that desirable by good institute on level governance and firm.

  14. Offentlighed og Public Relations

    Directory of Open Access Journals (Sweden)

    Lars Heltoft

    1993-09-01

    Full Text Available Lars Heltoft, der er en af grundlæggerne af Public Relationsuddannelsen på Roskilde Universitetscenter, kaster i artiklen et kritisk blik på den akademiske forskning i feltet public relations. Selv i nyere udgaver af PR-forskningen - af mange anset for "progressive", f.eks. James Grunings og Jon Whites arbejder - ser Lars Heltoft tydelige spor af PR- professionens selvforståelse og legitimationsbehov. Resultatet er, at den "offentlighed", der burde være kernen i den videnskabelige beskæftigelse med public relations, "forsvinder i den blå luft". Han argumenterer for, at Habermas´ forestilling om "offentlighed" stadig institutionaliserer mulig- heden for kritisk diskurs inden for feltet, samtidig med at han i sproghand- lingsteoretisk perspektiv problematiserer Habermas´ legitimationsbegreb, fordi det undtager private virksomheder og organisationer.

  15. microRNAs related to angiogenesis are dysregulated in endometrioid endometrial cancer.

    Science.gov (United States)

    Ramón, Luis A; Braza-Boïls, Aitana; Gilabert, Juan; Chirivella, Melitina; España, Francisco; Estellés, Amparo; Gilabert-Estellés, Juan

    2012-10-01

    Which is the role of microRNAs (miRNAs) related to several angiogenesis regulators such as VEGF-A (Vascular endothelial growth factor-A) and TSP-1 (Thrombospondin-1) in endometrial cancer? A dysregulated expression of miRNAs related to angiogenesis and an increase in the VEGF-A levels were observed in endometrial cancer in comparison with control. The different expression of miRNAs could modulate the expression of angiogenic and antiangiogenic factors, which may play an important role in the pathogenesis of endometrial cancer. Dysregulated miRNA expression has been previously evaluated in endometrial adenocarcinoma. To the best of our knowledge, there are no studies on the relationship between angiogenic factors and miRNAs in endometrial cancer. Case-control study: 41 patients with histologically proven endometrioid endometrial cancer and 56 women without endometrial cancer. RNAs isolated from tissue samples were analyzed using the GeneChip miRNA 2.0 Array platform (Affymetrix). TaqMan qRT-PCR was used to assess the expression of the selected miRNAs related to angiogenesis (miR-15b, -16, -17-5p, -20a, -21, -125a, -200b, -210, -214*, -221, -222 and -424), and VEGF-A and TSP-1 mRNAs were assessed by qRT-PCR using SYBR Green. Protein levels were quantified by ELISAs. Compared with the miRNAs in the control endometrium, eight miRNAs (miR-15b, -17-5p, -20a, -125a, -214*, -221, -222 and -424) were significantly down-regulated and two miRNAs (miR-200b and -210) were significantly up-regulated in the cancerous endometrium. A significant increase in VEGF-A mRNA and protein expression and in TSP-1 protein levels (P Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica (Instituto de Salud Carlos III, Fondo de Investigación Sanitaria, PI080185, PI0110091) and Red RECAVA (RD06/0014/0004), by Consellería de Sanidad (AP-141/11) and Consellería de Educación (PROMETEO/2011/027), Generalitat Valenciana, by Beca Fibrinolisis 2009 and Becario 2010

  16. Nuclear public relations campaign

    Energy Technology Data Exchange (ETDEWEB)

    1983-01-01

    A two-day hearing to investigate DOE's participation in a $30 million nuclear public relations program at a time when the country is asked to decrease spending and in conjunction with similar efforts by the nuclear industry focused on the issue of whether ratepayers or shareholders should finance the effort. Shelby Brewer, Assistant Secretary for Nuclear Energy, defended the expenditures as a response to public demand for information and the need to correct misinformation. The testimony of 14 other witnesses includes the views of citizen and professional groups, utilities, and government agencies. Their testimony is followed by additional material submitted for the record. (DCK)

  17. Public relations strategy

    International Nuclear Information System (INIS)

    Kukovica, T.; Mele, I.

    1996-01-01

    NIMBY (Not In My Back Yard) syndrome has become a major problem in the field of environmental planning. Also in Slovenia. Agency for Radwaste management was established by the Slovene government in 1991. Our main objective is to provide the final disposal of radioactive waste in Slovenia. Overcoming the NIMBY syndrome is therefore the primary aim of Agency's PR (public relations) strategy. Agency's public relations strategy was prepared in 1993. After very unpleasant experience with NIMBY syndrome in local community where one of the potential locations for low and intermediate level repository was identified the strategy was renewed in 1994. It is divided into two parts: information and education. The first one includes providing information to the media, surveys of press clippings, interviews, press conferences, public opinion polls and publishing articles. Agency's first task in the field of education was to prepare different materials like: leaflets, Agency's newspaper and videos. Materials were distributed to various target publics. There is also a special program of lectures for youngsters. All those activities and projects have been successfully realized within the last year. Plans of PR activities for this year are focused on informing the local community about remediation of temporary storage of radioactive waste near village Zavratec. Other new projects are also under preparation like: new leaflets, presentation on Internet, journalist's guide to rad waste management, most frequently asked questions and answers. (author)

  18. Public Relations in the Public Sector

    DEFF Research Database (Denmark)

    Valentini, Chiara

    2013-01-01

    of the Excellence Project in Public Relations and thus applies a research instrument similar to that used in other international scholarly investigations in public relations. The population comprises civil servants working in information and communication activities for Italian public administrations. Findings...... relations. Research limitations: Due to a lack of information on the exact number of public communication officers working in the Italian public administration and a too small number of respondents in one of the respondent groups, it is not possible to draw inferences or general conclusions from...... knowledge on strategic public relations and public communication by offering a specific analysis of the strategic management of information and communication programs in the Italian public administration....

  19. Public relations effectiveness in public health institutions.

    Science.gov (United States)

    Springston, Jeffrey K; Weaver Lariscy, Ruth Ann

    2005-01-01

    This article explores public relations effectiveness in public health institutions. First, the two major elements that comprise public relations effectiveness are discussed: reputation management and stakeholder relations. The factors that define effective reputation management are examined, as are the roles of issues and crisis management in building and maintaining reputation. The article also examines the major facets of stakeholder relations, including an inventory of stakeholder linkages and key audiences, such as the media. Finally, methods of evaluating public relations effectiveness at both the program level and the institutional level are explored.

  20. Tumour angiogenesis pathways: related clinical issues and implications for nuclear medicine imaging

    International Nuclear Information System (INIS)

    Wiele, Christophe van de; De Winter, Olivier; Dierckx, Rudi Andre; Oltenfreiter, Ruth; Slegers, Guido; Signore, Alberto

    2002-01-01

    Tumour angiogenesis is essential for growth, invasion and metastasis. Retrospective studies suggest that it is an independent prognostic factor that merits prospective validation. Furthermore, as tumour blood vessels show many differences from normal vessels and are not genetically unstable, they form a key area for therapy development. However, as anti-angiogenic therapy is primarily cytostatic and not cytotoxic, novel tailor-made specific end-points for treatment monitoring are required. In this regard, suitable molecular parameters for imaging tumour angiogenesis by means of nuclear medicine are being explored. Here we review current knowledge on the multiple pathways controlling tumour angiogenesis and try to assess which are the most clinically relevant for nuclear medicine imaging. Parameters that may influence the imaging potential of radiopharmaceuticals for angiogenesis imaging such as molecular weight and structure, their targeted location within the tumour and their usefulness in terms of specificity and constancy of the targeted molecular pathway are discussed. (orig.)

  1. Public Relations Sebagai Tools Marketing

    OpenAIRE

    Mukhriz, Dewi Wulandari

    2015-01-01

    This study, entitled "Public Relations As Marketing Tools In Increasing image in Hotel Inna Dharma Deli". The purpose of this study was to determine the influence of public relations activities as marketing tools to the image at the Hotel Inna Dharma Deli. A correlational study aimed to see how far the variable public relations activities as marketing tools affect the company's image variables. The theories used is communications, public relations, marketing, marketing public relations, an...

  2. Abnormalities in alternative splicing of angiogenesis-related genes and their role in HIV-related cancers

    Directory of Open Access Journals (Sweden)

    Mthembu NN

    2017-03-01

    Full Text Available Nonkululeko N Mthembu,1 Zukile Mbita,2 Rodney Hull,1 Zodwa Dlamini1 1Research, Innovation and Engagements, Mangosuthu University of Technology, Durban, 2Department of Biochemistry, Microbiology and Biotechnology, University of Limpopo, Sovenga, South Africa Abstract: Alternative splicing of mRNA leads to an increase in proteome biodiversity by allowing the generation of multiple mRNAs, coding for multiple protein isoforms of various structural and functional properties from a single primary pre-mRNA transcript. The protein isoforms produced are tightly regulated in normal development but are mostly deregulated in various cancers. In HIV-infected individuals with AIDS, there is an increase in aberrant alternative splicing, resulting in an increase in HIV/AIDS-related cancers, such as Kaposi’s sarcoma, non-Hodgkin’s lymphoma, and cervical cancer. This aberrant splicing leads to abnormal production of protein and is caused by mutations in cis-acting elements or trans-acting factors in angiogenesis-related genes. Restoring the normal regulation of alternative splicing of angiogenic genes would alter the expression of protein isoforms and may confer normal cell physiology in patients with these cancers. This review highlights the abnormalities in alternative splicing of angiogenesis-related genes and their implication in HIV/AIDS-related cancers. This allows us to gain an insight into the pathogenesis of HIV/AIDS-related cancer and in turn elucidate the therapeutic potential of alternatively spliced genes in HIV/AIDS-related malignancies. Keywords: vascular endothelial growth factor, oncogenic viruses, hypoxia induced factor 1, Kaposi’s sarcoma, non-Hodgkin’s lymphoma, therapies targeting alternative splicing

  3. Expression of angiogenesis-related genes in canine cortisol-secreting adrenocortical tumors.

    Science.gov (United States)

    Kool, M M J; Galac, S; Kooistra, H S; Mol, J A

    2014-04-01

    The aim of this study was to evaluate the expression of angiogenesis-related genes in canine cortisol-secreting adrenocortical tumors (ATs). Quantitative RT-PCR analysis revealed mRNA encoding for vascular endothelial growth factor, vascular endothelial growth factor receptors 1 and 2, angiopoietin 1 and 2 (ANGPT1 and ANGPT2), the splice variant ANGPT2443, the ANGPT-receptor Tie2, and basic fibroblast growth factor in 38 canine cortisol-secreting ATs (26 carcinomas and 12 adenomas) and 15 normal adrenals. The relative expression of both ANGPT2 and ANGPT2443 was higher in adenomas (P = 0.020 for ANGPT2 and P = 0.002 for ANGPT2443) and carcinomas (P = 0.003 for ANGPT2 and P cortisol-producing adrenocortical carcinoma cell line, we were able to demonstrate that the ANGPT2 expression was stimulated by cyclic adenosine monophosphate and progesterone but not by cortisol. In conclusion, canine cortisol-secreting ATs have enhanced ANGPT2 expression with a concomitant shift toward a proangiogenic state. On the basis of this information, treatment modalities may be developed that interfere with ANGPT2 expression, including inhibition of the cyclic adenosine monophosphate/protein kinase A pathway, or of the effect of ANGPT2, by using specific ANGPT2 inhibitors. Copyright © 2014 Elsevier Inc. All rights reserved.

  4. From Public Relations to Corporate Public Diplomacy

    DEFF Research Database (Denmark)

    Mogensen, Kirsten

    2017-01-01

    -win solutions supported by the general public. While existing research suggests that an important function of public relations is to create a perception of legitimacy and that the hope of economic and commercial public diplomacy is to create a perception of attractiveness among the public in foreign countries......This paper illustrates several factors that make corporate public diplomacy a fundamentally different approach to activities that aim at legitimacy alone. A case study of a suspended Chinese hydropower project (i.e., the Myitsone Dam) in northern Myanmar is presented to address the functional...... differences and their implications for corporate practice. In particular, it illustrates how public resistance can prevent the success of direct foreign investments despite favorable agreements with host governments; also, it shows that corporate public diplomacy can be used to develop sustainable win...

  5. Mediators of ocular angiogenesis

    Indian Academy of Sciences (India)

    2016-08-26

    Aug 26, 2016 ... Keywords. ocular angiogenesis; corneal neovascularization; retinal neovascularization; diabetic retinopathy; age-related macular degeneration; retinopathy of prematurity; VEGF; PEDF; Flt-1; Flk-1; endostatin; angiopoietin; erythropoietin; Tie2; inflammation; complement; gene therapy; TLR-3; Robo4.

  6. Angiogenesis Inhibitors

    Science.gov (United States)

    ... Peer Review and Funding Outcomes Step 4: Award Negotiation & Issuance Manage Your Award Grants Management Contacts Monitoring ... revealed the potential for complications that reflect the importance of angiogenesis in many normal body processes, such ...

  7. How public relations works: theoretical roots and public relations perspectives

    NARCIS (Netherlands)

    Ihlen, Ø.; van Ruler, B.

    2007-01-01

    Public relations is often studied from a managerial, instrumental perspective or a psychological, behavioral perspective. To understand the role of public relations in building trust or mistrust and to develop - or destroy - a license to operate, it needs also to be studied as a social phenomenon.

  8. Perempuan Dalam Dunia Public Relations

    Directory of Open Access Journals (Sweden)

    Novi Kurnia

    2004-03-01

    Full Text Available Literature review shows that women gain more access to job in public relations. Observation in Yogyakarta shows that women are not easily top position in corporation due to understatement of the role of public relations in organizational structure. Discrimination against women is minimal except on family allowance.

  9. Public Relations as Promotional Activity

    Directory of Open Access Journals (Sweden)

    Almira CURRI-MEMETI

    2011-11-01

    Full Text Available Public relations give opportunity to the organization to present its image and personality to its own “public”- users, supporters, sponsors, donors, local community and other public.It is about transferring the message to the public, but that is a twoway street. You must communicate with your public, but at the same time you must give opportunity to the public to communicate easier with you. The real public relations include dialog – you should listen to the others, to see things through their perspective. This elaborate is made with the purpose to be useful for every organization, not for the sensational promotion of its achievements, but to become more critical towards its work. Seeing the organization in the way that the other see it, you can become better and sure that you are giving to your users the best service possible.

  10. Transpupillary thermotherapy-induced modification of angiogenesis- and coagulation-related gene expression in the rat posterior fundus.

    Science.gov (United States)

    Ito, Yoko N; Ito, Mitsuteru; Takita, Hiroyasu; Yoneya, Shin; Peyman, Gholam A; Gehlbach, Peter L; Mori, Keisuke

    2006-07-20

    To study gene expression changes in the rat retina and choroid following transpupillary thermotherapy (TTT) and to identify molecular mechanisms that may enhance treatment of choroidal neovascularization, complicating age-related macular degeneration. One fundus of Brown Norway rats was treated with an 810 nm diode laser while the contralateral fundus received no treatment. The mRNA was extracted and processed for cDNA microarray analysis. Genes with increased expression were validated by semiquantitative reverse transcription polymerase chain reaction (PCR) and quantitative real-time PCR (qRT-PCR). Of the 14,815 cDNA elements on the array, 12 genes were up-regulated in TTT treated eyes. Upregulation of eight of these 12 genes could be verified by semiquantitative RT-PCR. The eight verified genes were EPCR, IL-1beta, MCP-1, TSP-1, Fgl, Asns, MT-2, and NMDMC, which included 4 angiogenesis- and coagulation-related genes. This study demonstrates upregulation of angiogenesis- and coagulation-related genes following TTT. The response profile and its temporal relationships provide insight into the molecular mechanisms that lead to vascular occlusion and antiangiogenesis induced by TTT.

  11. Knockdown of aberrantly expressed nuclear localized decorin attenuates tumour angiogenesis related mediators in oral cancer progression model in vitro.

    Science.gov (United States)

    Dil, Nyla; Banerjee, Abhijit G

    2012-06-08

    Oral cancer accounts for roughly 3% of cancer cases in the world with about 350,000 newly reported cases annually and a 5-year survival rate of only 50%. Majority of oral cancers are squamous cell carcinomas that originate in the oral mucosal epithelial linings. We have previously shown that in human malignant squamous cells carcinoma (SCC-25) as well as in dysplastic oral keratinocytes (DOK), a small leucine-rich multifunctional proteoglycan decorin is aberrantly expressed and localized in the nucleus where it interacts with nuclear epidermal growth factor receptor (EGFR). Post-transcriptional silencing of nuclear decorin significantly reduced IL-8 and IL8-dependent migration and invasion in these dysplastic and malignant oral epithelia. The objective of this study was to further examine the effects of nuclear decorin silencing on angiogenesis and angiogenesis related mediators in this oral cancer progression cell line model. We have used multiplex PCR, western blotting, and in vitro endothelial tube formation assay to study angiogenesis and related pathways in nuclear decorin silenced (stable knockdown) DOK and SCC-25 cells. Nuclear decorin knockdown resulted in significant down regulation of IL-8 expression, however IL-10, and TGF-β expression was not affected in either DOK or SCC25 cells as measured by multiplex RT PCR. IL-8 receptor CXCR 1 and 2 expression was slightly lower in nuclear decorin silenced cells indicating a contributing mechanism in previously shown reduced IL-8 mediated migration and invasion phenotype in these cells. IL-8 is known to induce Matrix metalloproteinase 9 (MMP9) which not only plays a role in tumour migration and invasion but also induces angiogenic switch. We found MMP9 to be significantly reduced in nuclear decorin silenced dysplastic and malignant oral epithelia. Other potent angiogenic mediators, VEGF189 and ANG-1 were either significantly reduced or completely abrogated in these cells. Angiogenesis as measured by endothelial

  12. RELATIONS WITH THE PUBLIC VERSUS PUBLIC RELATIONS IN LOCAL PUBLIC ADMINISTRATION

    Directory of Open Access Journals (Sweden)

    Bente Florina Maria

    2010-12-01

    Full Text Available Concomitant with the evolution of society, public relations are socially expressed only together with the explicit articulation of public categories and public organizations, once the individual becomes a citizen whose satisfaction is at the core of the public systems preoccupations, ignoring times long gone when the ordinary citizen and the majority of the public administration representatives couldnt tell apart the concept of public relations from that of relations with the public.

  13. New Media and Public Relations

    Directory of Open Access Journals (Sweden)

    Renata Demeterffy Lančić

    2010-12-01

    Full Text Available This article examines the importance of new communication technologies in terms of the development of a pluralistic public sphere and public relations (PR as one type of communication. In ageneral social context, where the media have lost their primary importance, there is an increasing need for an independent and free communication system. New communication technologies, primarily enabled by the advancement of the Internet, create new development opportunities to communicate to the public. Blogs, web forums, web pages, online-magazines, e-mail lists, chat rooms, social networks, etc. are new forms of public communication, where citizens have equal opportunity to participate in the public sphere, where communication becomes a re-exchange of opinion. Such networks have the potential to be public hearings, a fundamental basis of democracy. These types of media are particularly important in the fi eld of public relations because they improve communication and infl uence social change. The article highlights the signifi cant impact of new communication technologies on public relations and suggests the possibilities of manipulation that result from them. Unlike traditional methods, the new methods are far more subtle. The article concludes that the only possibility to protect computer users is via proper education.

  14. Angiogenesis, Cancer, and Vascular Aging

    Directory of Open Access Journals (Sweden)

    Junji Moriya

    2017-10-01

    Full Text Available Several lines of evidence have revealed that the angiogenic response to ischemic injury declines with age, which might account for the increased morbidity and mortality of cardiovascular disease (CVD among the elderly. While impairment of angiogenesis with aging leads to delayed wound healing or exacerbation of atherosclerotic ischemic diseases, it also inhibits the progression of cancer. Age-related changes of angiogenesis have been considered to at least partly result from vascular aging or endothelial cell senescence. There is considerable evidence supporting the hypothesis that vascular cell senescence contributes to the pathogenesis of age-related CVD, suggesting that vascular aging could be an important therapeutic target. Since therapeutic angiogenesis is now regarded as a promising concept for patients with ischemic CVD, it has become even more important to understand the detailed molecular mechanisms underlying impairment of angiogenesis in older patients. To improve the usefulness of therapeutic angiogenesis, approaches are needed that can compensate for impaired angiogenic capacity in the elderly while not promoting the development or progression of malignancy. In this review, we briefly outline the mechanisms of angiogenesis and vascular aging, followed by a description of how vascular aging leads to impairment of angiogenesis. We also examine potential therapeutic approaches that could enhance angiogenesis and/or vascular function in the elderly, as well as discussing the possibility of anti-senescence therapy or reversal of endothelial cell senescence.

  15. Public relations activities in BNFL

    Energy Technology Data Exchange (ETDEWEB)

    Phillips, B. [British Nuclear Fuels plc, Cheshire (United Kingdom)

    1993-12-31

    British Nuclear Fuels plc (BNFL) is a major industrial company employing 15,000 people and supporting another 50,000 jobs in British industry through it`s isnvestment program. BNFL is frequently in the news, mainly because of the Sellafield reprocessing plant in West Cumbria. The company`s public relation policy is described in this report.

  16. Anti-Urokinase Receptor Antisense Oligonucleotide (uPAR-aODN) to Prevent and Cure Long-Term Space Exploration-Related Retinal Pathological Angiogenesis

    Science.gov (United States)

    Lazzarano, Stefano; Lulli, Matteo; Fibbi, Gabriella; Margheri, Francesca; Papucci, Laura; Serrati, Simona; Witort, Ewa; Chilla, Anastasia; Lapucci, Andrea; Donnini, Martino; Quaglierini, Paolo; Romiti, Alice; Specogna, Rebecca; Del Rosso, Mario; Capaccioli, Sergio

    2008-06-01

    Angiogenesis underlies a variety of physiological processes and its possible deregulation during long term space exploration needs to be investigated. Angiogenesis is a multistep process of new blood capillary formation, where degradation of the extracellular matrix (ECM) by proteolytic enzymes, including uPA (urokinase plasminogen activator) and opening the way to migration of endothelial cells (EC), is critical. Plasminogen activation system regulates angiogenesis by both uPA-driven ECM degradation and uPA receptor (uPAR). Microgravity and low dose irradiations promote tissue neoangiogeenesis and neovascularization is often common occurence in ophthalmologic pathologies. We have designed and patented the uPAR antisense oligonucleotide (aODN) and evaluated its antiangiogenetic activity by EC cellular migration and capillary morphogenesis assays. The uPAR aODN treatment caused a 75% inhibition of human microvascular EC migration and a complete inhibition of capillary morphogenesis, suggesting its therapeutic application to prevent neoangiogenesis-related ophthalmologic pathologies during space exploration.

  17. Effect of Angiogenesis-Related Cytokines on Rotator Cuff Disease: The Search for Sensitive Biomarkers of Early Tendon Degeneration

    Directory of Open Access Journals (Sweden)

    Yulia A. Savitskaya

    2011-01-01

    Full Text Available Background Hallmarks of the pathogenesis of rotator cuff disease (RCD include an abnormal immune response, angiogenesis, and altered variables of vascularity. Degenerative changes enhance production of pro-inflammatory, anti-inflammatory, and vascular angiogenesis-related cytokines (ARC that play a pivotal role in the immune response to arthroscopic surgery and participate in the pathogenesis of RCD. The purpose of this study was to evaluate the ARC profile, ie, interleukin (IL: IL-1β, IL-6, IL-8, IL-10, vascular endothelial growth factor (VEGF, basic fibroblast growth factor (bFGF, and angiogenin (ANG, in human peripheral blood serum and correlate this with early degenerative changes in patients with RCD. Methods Blood specimens were obtained from 200 patients with RCD and 200 patients seen in the orthopedic clinic for nonrotator cuff disorders. Angiogenesis imaging assays was performed using power Doppler ultrasound to evaluate variables of vascularity in the rotator cuff tendons. Expression of ARC was measured by commercial Bio-Plex Precision Pro Human Cytokine Assays. Results Baseline concentrations of IL-1β, IL-8, and VEGF was significantly higher in RCD patients than in controls. Significantly higher serum VEGF levels were found in 85% of patients with RCD, and correlated with advanced stage of disease (r = 0.75; P < 0.0005, average microvascular density (r = 0.68, P < 0.005, and visual analog score (r = 0.75, P < 0.0002 in RCD patients. ANG and IL-10 levels were significantly lower in RCD patients versus controls. IL-1β and ANG levels were significantly correlated with degenerative tendon grade in RCD patients. No difference in IL-6 and bFGF levels was observed between RCD patients and controls. Patients with degenerative changes had markedly lower ANG levels compared with controls. Power Doppler ultrasound showed high blood vessel density in patients with tendon rupture. Conclusion The pathogenesis of RCD is associated with an

  18. Angiogenesis-related protein expression in bevacizumab-treated metastatic colorectal cancer: NOTCH1 detrimental to overall survival

    International Nuclear Information System (INIS)

    Paiva, Tadeu Ferreira Jr.; Jesus, Victor Hugo Fonseca de; Marques, Raul Amorim; Costa, Alexandre André Balieiro Anastácio da; Macedo, Mariana Petaccia de; Peresi, Patricia Maria; Damascena, Aline; Rossi, Benedito Mauro; Begnami, Maria Dirlei; Lima, Vladmir Cláudio Cordeiro de

    2015-01-01

    The development of targeted therapies has undoubtedly broadened therapeutic options for patients with colorectal cancer (CRC). The use of bevacizumab to reduce angiogenesis has been associated with improved clinical outcomes. However, an urgent need for prognostic/predictive biomarkers for anti-angiogenic therapies still exists. Clinical data of 105 CRC patients treated with bevacizumab in conjunction with chemotherapy were analyzed. The expression of vascular endothelial growth factor (VEGF) receptors, NOTCH1 receptor and its ligand DLL4 were determined by immunohistochemistry. Tumor samples were arranged on a tissue microarray. The association between protein expression and clinicopathological characteristics and outcomes was determined. Bevacizumab was administered as a first-line of treatment in 70.5 % of our cases. The median progression-free survival (PFS) was 10.2 months. The median overall survival (OS) of the total cohort was 24.4 months. Bevacizumab, as the first-line of treatment, and the presence of liver metastasis were independently associated with objective response rate. Membrane VEGFR1 and VEGFR3 expressions were associated with the presence of lung metastasis; interestingly, VEGFR3 was associated with less liver metastasis. NOTCH1 expression was associated with lymph node metastasis. There was a trend toward association between improved PFS and lower NOTCH1 expression (p = 0.06). Improved OS was significantly associated with lower NOTCH1 expression (p = 0.01). In a multivariate analysis, ECOG (Eastern Cooperative Oncology Group) performance status, liver metastasis, histological grade, and NOTCH1 expression were independently associated with OS. Our findings illustrated the expression profile of angiogenesis-related proteins and their association with clinicopathological characteristics and outcomes. NOTCH1 expression is a detrimental prognostic factor in metastatic CRC patients treated with chemotherapy plus bevacizumab. The online version of

  19. Public Relations In Nigerian Public Libraries: A Critical Assessment ...

    African Journals Online (AJOL)

    This paper critically assesses public relations in public libraries in Nigeria. A simple random sampling method was used to select 751 staff and 1161 users from 14 chosen public libraries. The result shows that about 60% of staff in public libraries were unaware of the importance of public relation in the delivery of effective ...

  20. On research in Public Relations

    Directory of Open Access Journals (Sweden)

    Dr. Sarelly Martínez Mendoza

    2007-01-01

    Full Text Available The investigation constitutes one of the forms to improve the public relations continuously (RRPP. For that reason, this article bets to retake the investigation processes to consolidate the discipline, and explains the types of investigation at great length (basic, introspective and applied that is used in RRPP. Also it reflects on the approaches of investigation (pursuits of a created atmosphere, audits of public relations, audits in communication, ethnographies and the studies of case, the techniques (analysis of content, focal analyses of the speech, focus groups or survey, and the instruments (questionnaires, tests or experiments, that they must be used in this discipline. Part of the principle of which the investigation, in all its phases, is the transforming element of the public relations. Today it is not possible to start up successful program of RRPP but leans continuously in the investigation. The investigation marks the viability of a RRPP program. The intuition, the inspiration and the improvisation, as only elements of support, must stay in the past, and must be replaced by the scientific research.

  1. Rally as a Political Public Relations Strategy for Public Acceptance ...

    African Journals Online (AJOL)

    This study examines the assessment of the use of rally as a political public relations strategy for public acceptance of a political party during the 2015 presidential elections in Lagos State. Public relations uses tactical methods of communication to build relations between an organisation and its internal and external publics.

  2. Public relations activities at JAPC

    International Nuclear Information System (INIS)

    Kamiyabu, Kumi

    2011-01-01

    The Japan Atomic Power Company (JAPC) is the only electric power company in Japan solely engaged in nuclear energy. In order to fulfill our role as a pioneer in nuclear power generation, various projects have been undertaken, including the construction of the first commercial nuclear power plant in Japan and the construction, operation and decommissioning of power plants in Tokaimura in Ibaraki prefecture and in Tsuruga city in Fukui prefecture. JAPC is an electric nuclear power generation company which sells electricity directly to the electric companies. Since JAPC doesn't have retail customers, it has limited opportunities to come in contact with local residents. It is essential to gain the confidence and understanding of nuclear power by local residents in order to promote our projects and to manage our nuclear power plants. Under these circumstances, JAPC has steadily developed public relations in local areas and surrounding neighborhoods through an action policy of two-way communication. In this presentation, the two-way communication public relations policy will be explained. I would like to describe the achievements of the two-way communication policy by referring to the results of public opinion surveys conducted in Ibaraki and Fukui prefectures. (author)

  3. Endoglin inhibition leads to intussusceptive angiogenesis via activation of factors related to COUP-TFII signaling pathway.

    Directory of Open Access Journals (Sweden)

    Ruslan Hlushchuk

    Full Text Available Angiogenesis is a highly coordinated, extremely complex process orchestrated by multiple signaling molecules and blood flow conditions. While sprouting mode of angiogenesis is very well investigated, the molecular mechanisms underlying intussusception, the second mode of angiogenesis, remain largely unclear. In the current study two molecules involved in vascular growth and differentiation, namely endoglin (ENG/CD105 and chicken ovalbumin upstream promoter transcription factor II (COUP-TFII were examined to unravel their specific roles in angiogenesis. Down- respectively up-regulation of both molecules tightly correlates with intussusceptive microvascular growth. Upon ENG inhibition in chicken embryo model, formation of irregular capillary meshwork accompanied by increased expression of COUP-TFII could be observed. This dynamic expression pattern of ENG and COUP-TFII during vascular development and remodeling correlated with formation of pillars and progression of intussusceptive angiogenesis. Similar findings could be observed in mammalian model of acute rat Thy1.1 glomerulonephritis, which was induced by intravenous injection of anti-Thy1 antibody and has shown upregulation of COUP-TFII in initial phase of intussusception, while ENG expression was not disturbed compared to the controls but decreased over the time of pillar formation. In this study, we have shown that ENG inhibition and at the same time up-regulation of COUP-TFII expression promotes intussusceptive angiogenesis.

  4. Using Crisis Simulations in Public Relations Education

    Science.gov (United States)

    Veil, Shari R.

    2010-01-01

    Objectives: Students will demonstrate research, decision making, team building, and public speaking skills, while applying issues management and crisis communication concepts in a realistic setting. Courses: Introduction to Public Relations, Public Relations Cases, Crisis Communication.

  5. Oxalomalate reduces expression and secretion of vascular endothelial growth factor in the retinal pigment epithelium and inhibits angiogenesis: Implications for age-related macular degeneration

    Directory of Open Access Journals (Sweden)

    Sung Hwan Kim

    2016-12-01

    Full Text Available Clinical and experimental observations indicate a critical role for vascular endothelial growth factor (VEGF, secreted by the retinal pigment epithelium (RPE, in pathological angiogenesis and the development of choroidal neovascularization (CNV in age-related macular degeneration (AMD. RPE-mediated VEGF expression, leading to angiogenesis, is a major signaling mechanism underlying ocular neovascular disease. Inhibiting this signaling pathway with a therapeutic molecule is a promising anti-angiogenic strategy to treat this disease with potentially fewer side effects. Oxalomalate (OMA is a competitive inhibitor of NADP+-dependent isocitrate dehydrogenase (IDH, which plays an important role in cellular signaling pathways regulated by reactive oxygen species (ROS. Here, we have investigated the inhibitory effect of OMA on the expression of VEGF, and the associated underlying mechanism of action, using in vitro and in vivo RPE cell models of AMD. We found that OMA reduced the expression and secretion of VEGF in RPE cells, and consequently inhibited CNV formation. This function of OMA was linked to its capacity to activate the pVHL-mediated HIF-1α degradation in these cells, partly via a ROS-dependent ATM signaling axis, through inhibition of IDH enzymes. These findings reveal a novel role for OMA in inhibiting RPE-derived VEGF expression and angiogenesis, and suggest unique therapeutic strategies for treating pathological angiogenesis and AMD development.

  6. Angiogenesis in vestibular schwannomas

    DEFF Research Database (Denmark)

    Møller, Martin Nue; Werther, Kim; Nalla, Amarnadh

    2010-01-01

    targets the angiogenic process by investigation of tumor expression of MMP-2, MMP-9, and tissue inhibitors of metalloproteinase (TIMP)-1. A possible correlation with gender, patient age, symptom duration, tumor size, and the absolute and relative growth rate is explored.......Vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) are potent mediators of tumor angiogenesis. It has been demonstrated that vestibular schwannoma VEGF expression correlates with tumor growth pattern, whereas knowledge on the expression of MMPs is lacking. This study...

  7. miR-126 Regulation of Angiogenesis in Age-Related Macular Degeneration in CNV Mouse Model

    Directory of Open Access Journals (Sweden)

    Lei Wang

    2016-06-01

    Full Text Available miR-126 has recently been implicated in modulating angiogenic factors in vascular development. Understandings its biological significance might enable development of therapeutic interventions for diseases like age-related macular degeneration (AMD. We aimed to determine the role of miR-126 in AMD using a laser-induced choroidal neovascularization (CNV mouse model. CNV was induced by laser photocoagulation in C57BL/6 mice. The CNV mice were transfected with scrambled miR or miR-126 mimic. The expression of miR-126, vascular endothelial growth factor-A (VEGF-A, Kinase insert domain receptor (KDR and Sprouty-related EVH1 domain-containing protein 1 (SPRED-1 in ocular tissues were analyzed by qPCR and Western blot. The overexpression effects of miR-126 were also proven on human microvascular endothelial cells (HMECs. miR-126 showed a significant decrease in CNV mice (p < 0.05. Both mRNA and protein levels of VEGF-A, KDR and SPRED-1 were upregulated with CNV; these changes were ameliorated by restoration of miR-126 (p < 0.05. CNV was reduced after miR-126 transfection. Transfection of miR-126 reduced the HMECs 2D-capillary-like tube formation (p < 0.01 and migration (p < 0.01. miR-126 has been shown to be a negative modulator of angiogenesis in the eye. All together these results high lights the therapeutic potential of miR-126 suggests that it may contribute as a putative therapeutic target for AMD in humans.

  8. Fighting bias through public relations

    Energy Technology Data Exchange (ETDEWEB)

    Denny, R.; Russell, V.

    1994-08-01

    Traditionally, the role of public relations (PR) has been twofold: to demonstrate social responsibility or corporate citizenship, and to respond to crisis. In periods of stability and increasing cost accountability, PR activities are vulnerable to budgets cuts. But should they be What can and should PR be in an era of [open quotes]customer focus[close quotes] and how can the effect of PR activities be measured Utility companies and their customers (especially residential) often speak in different languages. What the company views as a valuable addition to quality of service, the residential customer might either view as irrelevant or threatening, or not [open quote]see[close quote] at all. Miscommunication between utilities and their customers goes deeper than generalized distrust of institutions because it is grounded in American cultural beliefs about utilities, big business, and free markets. Reducing the negative effect of these beliefs is possible through PR activities. Thus, rather than being a peripherial part of the marketing plan, PR is critical to achieving company goals-the translocator in the dialogue between company and customer.

  9. Targeting Vascular Endothelial Growth Factor Receptor 2 and Protein Kinase D1 Related Pathways by a Multiple Kinase Inhibitor in Angiogenesis and Inflammation Related Processes In Vitro

    Science.gov (United States)

    Varga, Attila; Gyulavári, Pál; Greff, Zoltán; Futosi, Krisztina; Németh, Tamás; Simon-Szabó, Laura; Kerekes, Krisztina; Szántai-Kis, Csaba; Brauswetter, Diána; Kokas, Márton; Borbély, Gábor; Erdei, Anna; Mócsai, Attila; Kéri, György; Vántus, Tibor

    2015-01-01

    Emerging evidence suggests that the vascular endothelial growth factor receptor 2 (VEGFR2) and protein kinase D1 (PKD1) signaling axis plays a critical role in normal and pathological angiogenesis and inflammation related processes. Despite all efforts, the currently available therapeutic interventions are limited. Prior studies have also proved that a multiple target inhibitor can be more efficient compared to a single target one. Therefore, development of novel inflammatory pathway-specific inhibitors would be of great value. To test this possibility, we screened our molecular library using recombinant kinase assays and identified the previously described compound VCC251801 with strong inhibitory effect on both VEGFR2 and PKD1. We further analyzed the effect of VCC251801 in the endothelium-derived EA.hy926 cell line and in different inflammatory cell types. In EA.hy926 cells, VCC251801 potently inhibited the intracellular activation and signaling of VEGFR2 and PKD1 which inhibition eventually resulted in diminished cell proliferation. In this model, our compound was also an efficient inhibitor of in vitro angiogenesis by interfering with endothelial cell migration and tube formation processes. Our results from functional assays in inflammatory cellular models such as neutrophils and mast cells suggested an anti-inflammatory effect of VCC251801. The neutrophil study showed that VCC251801 specifically blocked the immobilized immune-complex and the adhesion dependent TNF-α -fibrinogen stimulated neutrophil activation. Furthermore, similar results were found in mast cell degranulation assay where VCC251801 caused significant reduction of mast cell response. In summary, we described a novel function of a multiple kinase inhibitor which strongly inhibits the VEGFR2-PKD1 signaling and might be a novel inhibitor of pathological inflammatory pathways. PMID:25874616

  10. Targeting vascular endothelial growth factor receptor 2 and protein kinase D1 related pathways by a multiple kinase inhibitor in angiogenesis and inflammation related processes in vitro.

    Directory of Open Access Journals (Sweden)

    Attila Varga

    Full Text Available Emerging evidence suggests that the vascular endothelial growth factor receptor 2 (VEGFR2 and protein kinase D1 (PKD1 signaling axis plays a critical role in normal and pathological angiogenesis and inflammation related processes. Despite all efforts, the currently available therapeutic interventions are limited. Prior studies have also proved that a multiple target inhibitor can be more efficient compared to a single target one. Therefore, development of novel inflammatory pathway-specific inhibitors would be of great value. To test this possibility, we screened our molecular library using recombinant kinase assays and identified the previously described compound VCC251801 with strong inhibitory effect on both VEGFR2 and PKD1. We further analyzed the effect of VCC251801 in the endothelium-derived EA.hy926 cell line and in different inflammatory cell types. In EA.hy926 cells, VCC251801 potently inhibited the intracellular activation and signaling of VEGFR2 and PKD1 which inhibition eventually resulted in diminished cell proliferation. In this model, our compound was also an efficient inhibitor of in vitro angiogenesis by interfering with endothelial cell migration and tube formation processes. Our results from functional assays in inflammatory cellular models such as neutrophils and mast cells suggested an anti-inflammatory effect of VCC251801. The neutrophil study showed that VCC251801 specifically blocked the immobilized immune-complex and the adhesion dependent TNF-α -fibrinogen stimulated neutrophil activation. Furthermore, similar results were found in mast cell degranulation assay where VCC251801 caused significant reduction of mast cell response. In summary, we described a novel function of a multiple kinase inhibitor which strongly inhibits the VEGFR2-PKD1 signaling and might be a novel inhibitor of pathological inflammatory pathways.

  11. Public relations in Europe: A kaleidoscopic picture

    NARCIS (Netherlands)

    van Ruler, A.A.; Vercic, D.; Flodin, B.; Buetschi, G.

    2001-01-01

    Focuses on the Delphi research project, a part of the European Public Relations Body of Knowledge project, which questions the existence of a European authenticity of public relations. Description of the study design; Discussion on public relations as a professional management function; Conclusions.

  12. Mediators of ocular angiogenesis

    Indian Academy of Sciences (India)

    . Pathologic angiogenesis in the eye can lead to severe visual impairment. In our review, we discuss the roles of both pro-angiogenic and anti-angiogenic molecular players in corneal angiogenesis, proliferative diabetic retinopathy, exudative ...

  13. Kaempferol targets estrogen-related receptor α and suppresses the angiogenesis of human retinal endothelial cells under high glucose conditions.

    Science.gov (United States)

    Wu, Yan; Zhang, Qinmei; Zhang, Rui

    2017-12-01

    Diabetic retinopathy (DR) is the most common complication of diabetes and a major cause of new-onset blindness in the developed world. The present study aimed to examine the effect of kaempferol on high glucose-induced human retinal endothelial cells (HRECs) in vitro . The expression levels of various mRNAs and proteins were measured by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blotting, respectively. The target of kaempferol was determined using a luciferase reporter assay. In addition, HREC proliferation, migration and cell sprouting were determined using Cell Counting kit-8, wound scratch and tube formation assays, respectively. RT-qPCR and western blotting results showed that treatment with 30 mM glucose for 12, 24 and 48 h increased the expression level of estrogen-related receptor α (ERRα) mRNA and protein. The luciferase reporter assay demonstrated that kaempferol inhibited ERRα activity in HRECs. Compared with 5 mM normal glucose treatment, high (30 mM) glucose significantly promoted the proliferation, migration and tube formation of HRECs, which was antagonized by 10 and 30 µM kaempferol in a dose-dependent manner. Treatment with 30 mM glucose also increased the expression of vascular endothelial growth factor (VEGF) mRNA and protein, and the expression levels of VEGF mRNA and protein were suppressed by kaempferol (10 and 30 µM). Kaempferol (30 µM) treatment also increased the expression levels of thrombospondin 1 (TSP-1) and a disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS-1) mRNA; however, TSP-1 and ADAMTS-1 levels did not differ between high glucose and normal (5 mM) glucose conditions. The results of this study suggest that kaempferol targets ERRα and suppresses the angiogenesis of HRECs under high glucose conditions. Kaempferol may be a potential drug for use in controlling the progression of DR; however, in vivo studies are required to evaluate its efficacy and safety.

  14. Public Relations: Roles, Entry Requirements and Professionalism

    Directory of Open Access Journals (Sweden)

    Kadek Dwi Cahaya Putra

    2013-12-01

    Full Text Available Abstract: This paper attempts to describe that there is a chance for non-Public Relations graduates to work as or at the Public Relations industry. Studies have shown that Public Relations practitioners are mostly from generalist background (not Public Relations and even come into the job by chance. A Public Relations is a very sociable person, possess a mix of functional, managerial and negotiating abilities as well as analytical and well-developed communication and understand people and human psychology. With working roles of Expert Prescriber, Communication Facilitator, Problem Solving Facilitator and Communication Technician, a Public Relations needs to be well prepared by learning foreign language, joining personality improvement course, developing networking and understanding computer and communication technology. Areas of where a Public relations works are in-house (organization/company, consultancy and freelance practitioner having various titles showing their main function in the organization such as public affairs, event manager, community relations manager, marketing communication executive, employee relations manager, corporate communications manager, media coordinator. As there is an increased challenge of Public Relations’s professionalism, a true practitioner is best prepared by educational institutions with lecturers having sound education and practice combined with extensive link-and -match research and industrial-practical placement for the graduates.

  15. Functional inhibition of UQCRB suppresses angiogenesis in zebrafish

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Yoon Sun; Jung, Hye Jin [Chemical Genomics National Research Laboratory, Department of Biotechnology, Translational Research Center for Protein Function Control, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749 (Korea, Republic of); Seok, Seung Hyeok [Department of Microbiology and Immunology, Institute for Experimental Animals, Seoul National University College of Medicine, Seoul 110-799 (Korea, Republic of); Payumo, Alexander Y.; Chen, James K. [Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305 (United States); Kwon, Ho Jeong, E-mail: kwonhj@yonsei.ac.kr [Chemical Genomics National Research Laboratory, Department of Biotechnology, Translational Research Center for Protein Function Control, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749 (Korea, Republic of)

    2013-04-19

    Highlights: ► This is the first functional characterization of UQCRB in vivo model. ► Angiogenesis is inhibited with UQCRB loss of function in zebrafish. ► UQCRB is introduced as a prognostic marker for mitochondria- and angiogenesis-related diseases. -- Abstract: As a subunit of mitochondrial complex III, UQCRB plays an important role in complex III stability, electron transport, and cellular oxygen sensing. Herein, we report UQCRB function regarding angiogenesis in vivo with the zebrafish (Danio rerio). UQCRB knockdown inhibited angiogenesis in zebrafish leading to the suppression of VEGF expression. Moreover, the UQCRB-targeting small molecule terpestacin also inhibited angiogenesis and VEGF levels in zebrafish, supporting the role of UQCRB in angiogenesis. Collectively, UQCRB loss of function by either genetic and pharmacological means inhibited angiogenesis, indicating that UQCRB plays a key role in this process and can be a prognostic marker of angiogenesis- and mitochondria-related diseases.

  16. PUBLIC RELATIONS AS AN INFORMATION PROCESS PHENOMENON

    Directory of Open Access Journals (Sweden)

    TKACH L. M.

    2016-06-01

    Full Text Available Formulation of the problem. If public relations as a phenomenon of information management are examined, we deal with the question of knowledge content and nature of relationship of PR with environment, ability to manage the perception and attitude of people to events in the environment; ensure priority of information over other resources. Goal. To investigate the concept of "public relations" of foreign and domestic experts; consider the typology of the public and the "laws" of public opinion; define the basic principles according to which relations with public should be built, and to identify PR activities as a kind of social communication. Conclusions. Public relations on the basis of advanced information and communication technologies create fundamentally new opportunities for information control and influence on public consciousness.

  17. Public Relations Applications in Librarianship and Television

    Directory of Open Access Journals (Sweden)

    Erol Yılmaz

    1999-12-01

    Full Text Available Public relations is an indispensable management function for an organization to reach its target audiences so as to serve them better and, at the same time, to upgrade its status in society as an organization. Television, as mass communication medium, is used effectively in public relations in librarianship. Researches showed that planned public relations is not utilized in the field of librarianship in our country, and television is not made use of for this purpose.

  18. Pension System Related Public Politics

    Directory of Open Access Journals (Sweden)

    LIVIU RADU

    2015-05-01

    Full Text Available This paper aims to find some answers regarding the long term sustainability of the pension system. Romania’s pension system originates from the invalidity insurances and pension system designed by the German cancellor Otto Eduard Leopold von Bismark in 1889. From a European perspective, Romania has to fill an obvious gap regarding the reformation of the national public pension system. International experience, particularly of the last 130 years, indicates that, in actuality, multiple pension systems have been put into function in most of the world’s countries and which are diferenciated by some elements (organizing and managing the system, defyning pension rights, method of forming the resources, the pension’s level rapported to the average income etc. and after the eficacity degree dependent on internal influences, social, economic and demographic environment, and last but not least by the political factor.

  19. Public relations for a national observatory

    Science.gov (United States)

    Finley, David G.

    The National Radio Astronomy Observatory (NRAO) is a government-funded organization providing state-of-the art observational facilities to the astronomical community on a peer-reviewed basis. In this role, the NRAO must address three principal constituencies with its public-relations efforts. These are: the astronomical community; the funding and legislative bodies of the Federal Government; and the general public. To serve each of these constituencies, the Observatory has developed a set of public-relations initiatives supported by public-relations and outreach professionals as well as by management and scientific staff members. The techniques applied and the results achieved in each of these areas are described.

  20. Peran Strategis Public Relations di Perguruan Tinggi

    Directory of Open Access Journals (Sweden)

    Ike Devi Sulistyaningtyas

    2013-12-01

    Full Text Available Abstracts: Public Relations emphasizes in building and maintaining a relationship between an organization and its public. It is applied also for a higher education institution or university. Nowadays, public relations in higher education institution become an integral part of the management team. It must contribute to achieve organizational goals and demonstrate an organizational accountability identified by measurable result. Synergy and cooperation are the strategic way to reach good relationship and reputation.

  1. Public relations metrics: research and evaluation

    NARCIS (Netherlands)

    van Ruler, B.; Tkalac Verčič, A.; Verčič, D.

    2008-01-01

    Responding to the increasing need in academia and the public relations profession, this volume presents the current state of knowledge in public relations measurement and evaluation. The book brings together ideas and methods that can be used throughout the world, and scholars and practitioners from

  2. Transformative Learning Approaches for Public Relations Pedagogy

    Science.gov (United States)

    Motion, Judy; Burgess, Lois

    2014-01-01

    Public relations educators are frequently challenged by students' flawed perceptions of public relations. Two contrasting case studies are presented in this paper to illustrate how socially-oriented paradigms may be applied to a real-client project to deliver a transformative learning experience. A discourse-analytic approach is applied within the…

  3. Peritoneal fluid reduces angiogenesis-related microRNA expression in cell cultures of endometrial and endometriotic tissues from women with endometriosis.

    Directory of Open Access Journals (Sweden)

    Aitana Braza-Boïls

    Full Text Available UNLABELLED: Endometriosis, defined as the presence of endometrium outside the uterus, is one of the most frequent gynecological diseases. It has been suggested that modifications of both endometrial and peritoneal factors could be implicated in this disease. Endometriosis is a multifactorial disease in which angiogenesis and proteolysis are dysregulated. MicroRNAs (miRNAs are small non-coding RNAs that regulate the protein expression and may be the main regulators of angiogenesis. Our hypothesis is that peritoneal fluid from women with endometriosis could modify the expression of several miRNAs that regulate angiogenesis and proteolysis in the endometriosis development. The objective of this study has been to evaluate the influence of endometriotic peritoneal fluid on the expression of six miRNAs related to angiogenesis, as well as several angiogenic and proteolytic factors in endometrial and endometriotic cell cultures from women with endometriosis compared with women without endometriosis. METHODS: Endometrial and endometriotic cells were cultured and treated with endometriotic and control peritoneal fluid pools. We have studied the expression of six miRNAs (miR-16, -17-5p, -20a, -125a, -221, and -222 by RT-PCR and protein and mRNA levels of vascular endothelial growth factor-A, thrombospondin-1, urokinase plasminogen activator and plasminogen activator inhibitor-1 by ELISA and qRT-PCR respectively. RESULTS: Control and endometriotic peritoneal fluid pools induced a significant reduction of all miRNAs levels in endometrial and endometriotic cell cultures. Moreover, both peritoneal fluids induced a significant increase in VEGF-A, uPA and PAI-1 protein levels in all cell cultures without significant increase in mRNA levels. Endometrial cell cultures from patients treated with endometriotic peritoneal fluid showed lower expression of miRNAs and higher expression of VEGF-A protein levels than cultures from controls. In conclusion , this "in vitro

  4. Political public relations in the European Union

    DEFF Research Database (Denmark)

    Valentini, Chiara

    2013-01-01

    This article examines the state of political public relations in the European Union by specifically focusing on reputation management and relationship management. Its arguments are based on a theoretical review of the literature of political public relations, reputation and relationship management......, and EU communication. The article suggests an in-depth examination of the nature of some of the EU’s major problems in political public relations, and contributes to a more nuanced understanding of the possibilities and limitations of applying reputation and relationship management constructs...

  5. Public relations policy: The Electronuclear experience

    International Nuclear Information System (INIS)

    Soares, Luiz

    2000-01-01

    This presentation discusses the following topics: Historical and Cultural Aspects of Electrical Sector in Brazil; Nuclear Power and Public Acceptance in Brazil; The chances decision of Angra 3; Community Activities of the ELETRONUCLEAR Regional Programs and Emergency Planning Department whose function is to promote activities with or for the communities of Angra dos Reis region; Public Relations Actions

  6. Public Sector Industrial Relations: Recent Developments.

    Science.gov (United States)

    Beaumont, Phil; Leopold, John

    1985-01-01

    This issue reviews trends in public sector employment (particularly in the light of government policy to reduce it), wages (in a context of cash limits), and strikes and other forms of industrial action. It also considers recent developments in the structure, organization, and policy of the "actors" in public sector industrial relations.…

  7. Using public relations to market nursing service.

    Science.gov (United States)

    Camuñas, C

    1986-10-01

    Planned, skillful use of public relations in marketing nursing services can facilitate achievement of the nursing organization's goals and objectives. The local community, news media, bankers, local politicians, government officials, and social action groups all can take an active or reactive interest in nursing's activities. Public relations can provide an effective approach for achieving optimal results within the political and economic constraints of the current marketplace.

  8. Public relations work at a regional level

    Energy Technology Data Exchange (ETDEWEB)

    Kirchhoff, H.R.

    1982-04-01

    With 'Elektrizitaets-AG Mitteldeutschland (EAM)' (power corporation central Germany) - head office in Kassel and five works maintained in Kassel, Goettingen, Marburg, Dillenburg and Hanau - public relations work has a tradition. It is seen as conscious, planned and continued effort to build up the public understanding: Public relations work is intended to present the enterprise as a community with a multitude of technical, economic and social tasks, which can be carried out with optimal success only if supported by the confidence of society.

  9. Peran Public Relations dalam Komunikasi Organisasi

    Directory of Open Access Journals (Sweden)

    Aswad Ishak

    2012-01-01

    Full Text Available Organization is currently experiencing growth and remarkable development. An increasingly diverse public characters, both interal and external, require special handling in communicating to them. Communication activities of the organization is a strategic communications activities that need to be run by the organization. This communication activities involving management as important decision makers in the organization. Through public relations activities of the organization’s strategic communication can run well. Public relations must have the full support of management to be able to carry out the task.

  10. Soliton driven angiogenesis.

    Science.gov (United States)

    Bonilla, L L; Carretero, M; Terragni, F; Birnir, B

    2016-08-09

    Angiogenesis is a multiscale process by which blood vessels grow from existing ones and carry oxygen to distant organs. Angiogenesis is essential for normal organ growth and wounded tissue repair but it may also be induced by tumours to amplify their own growth. Mathematical and computational models contribute to understanding angiogenesis and developing anti-angiogenic drugs, but most work only involves numerical simulations and analysis has lagged. A recent stochastic model of tumour-induced angiogenesis including blood vessel branching, elongation, and anastomosis captures some of its intrinsic multiscale structures, yet allows one to extract a deterministic integropartial differential description of the vessel tip density. Here we find that the latter advances chemotactically towards the tumour driven by a soliton (similar to the famous Korteweg-de Vries soliton) whose shape and velocity change slowly. Analysing these collective coordinates paves the way for controlling angiogenesis through the soliton, the engine that drives this process.

  11. Retinal angiogenesis in development and disease

    Science.gov (United States)

    Gariano, Ray F.; Gardner, Thomas W.

    2004-12-01

    The retina has long been regarded as `an approachable part of the brain' for investigating neurosensory processes. Cell biologists are now capitalizing on the accessibility of the retina to investigate important aspects of developmental angiogenesis, including how it relates to neuronal and glial development, morphogenesis, oxygen sensing and progenitor cells. Pathological angiogenesis also occurs in the retina and is a major feature of leading blinding diseases, particularly diabetic retinopathy. The retina and its clinical disorders have a pivotal role in angiogenesis research and provide model systems in which to investigate neurovascular relationships and angiogenic diseases.

  12. Creative communication in public relations activities

    Directory of Open Access Journals (Sweden)

    Dalibor Jakus

    2013-12-01

    Full Text Available This article discusses several approaches to new waves of public relations. Emphasis is given to the creative impulse since many public relations professionals are less familiar with it than other forms of communication. Five criteria are suggested for structuring creative communications: 1. learning how to be a good storyteller; 2. visual communication is the content that could increasingly build strong relationships with audiences; 3. the PR practitioner’s challenge is to evaluate what people are discussing and identify the recurring issues in their marketplace; 4. recognizing that local is new global; and 5. predicate that PR is constantly changing. People who work in public relations possess the skill of offering arguments that will convince the people themselves of something. However, these skills can be offered in traditional or creative forms of expression. If we define public relations as the management of an organization’s communication with its public, then we are referring to the traditional dimension of public relations, the basis and ultimate goal of which are to cultivate relationships with the participants of the process in order to obtain support and to build trust and reputation.

  13. Ethics and professionalism in public relations

    Directory of Open Access Journals (Sweden)

    Krstić Ana

    2009-01-01

    Full Text Available The subjects of this paper are ethics and professionalism, topics closely linked in contemporary theory, and especially in practice of public relations, whose significance is increasingly coming to the spotlight of experts from this area. Several definitions, classification, the historical development and principles of theories of ethics most frequently used in ethical decision-making within a business environment, have been presented in the first chapter in the endeavor to ascertain the concept of ethics. The next chapter concerns the duties a public relations expert must pay attention to while carrying out his or her activities. Those are: duty towards oneself, towards the organization, society and profession, within which, in the case of a conflict of interest, the duty towards society (so-called social responsibility, or professional duty, must prevail. The chapter that follows concerns ethical problems in the contemporary practice of public relations: the competence of practitioners, possible conflicts of interest and the very sensitive area of media relations. The chapter on models of ethical decision-making involves concrete experts' advice on decision making which are firmly based on ethical principles. Next section concerns professionalism and professional education in public relations. Recommendations concerning topics which should be included in the university education in this area are also presented. The focus is on the following: the absence of standards that would establish who can work in public relations and under which conditions; the lack of a specified educational minimum and expertise which a practitioner should possess; the need for practitioners to be the members of professional associations, as well as to adhere to a required ethical codex. Some of the most significant world public relations associations are mentioned and at the end, and a review of the state of public relations in Serbia is given.

  14. Upregulation of collagen VIII following porcine coronary artery angioplasty is related to smooth muscle cell migration not angiogenesis.

    Science.gov (United States)

    Sinha, S; Kielty, C M; Heagerty, A M; Canfield, A E; Shuttleworth, C A

    2001-10-01

    Type VIII collagen is upregulated after vessel injury, and this collagen has been implicated in both smooth muscle cell migration and angiogenesis. This study examines the temporal and spatial pattern of expression of type VIII collagen in porcine coronary vessels at specific time points after balloon angioplasty. In situ hybridization studies demonstrated that collagen VIII messenger ribonucleic acid (mRNA) was markedly elevated in the neoadventitia at 3 days post-angioplasty. By 14 days, elevated collagen VIII message was seen mainly in the neointima and this expression decreased to background levels by 90 days. The distribution of collagen VIII protein, detected using immunohistochemistry, was similar but the up-regulation lagged behind the mRNA increase by a few days. Pre-treatment of sections with pepsin highlighted variations in the organization and appearance of extracellular collagen VIII containing structures in both injured and normal vessels. New vessel formation was evident in the neoadventitia after 3 days, but there was no colocalization of type VIII collagen immunostaining with that of von Willebrand factor (a marker of endothelial cells) in the neoadventitia. These data show that up-regulation of collagen VIII in the neoadventitia is an important early marker of the coronary arterial response to injury, and is not associated with new vessel formation.

  15. Analisis Framing dalam Riset Public Relations

    Directory of Open Access Journals (Sweden)

    NARAYANA MAHENDRA PRASTYA

    2016-12-01

    Full Text Available This paper aims to give description about how to use frame analysis in Public Relations (PR research. The author use two framing models: Entman and Pan & Kosicki. The object is organization official statement about particular issue. Frame analysis method rarely used in Public Relations research. This methods commonly use in journalism study, to analyse the news in media. Meanwhile, the key word of framing is the social construction of reality. Organization can make social construction of realty in their official statement. In acacemic term, frame analysis in PR research is useful to know how organization positioned themselves in particular situation. Other benefit is use to evaluat whether the organization frame is conformable with the public opinion or agenda setting media or not. In practical term, frame analysis give benefit for PR practitioner to create the message that can be undserstood by public, also give positive image for organization.

  16. Reduction of Endogenous Angiogenesis Inhibitors in Bruch’s Membrane of the Submacular Region in Eyes With Age-Related Macular Degeneration

    Science.gov (United States)

    Bhutto, Imran A.; Uno, Koichi; Merges, Carol; Zhang, Lei; McLeod, D. Scott; Lutty, Gerard A.

    2016-01-01

    Objectives To determine the relative levels of 3 potent inhibitors of angiogenesis (endostatin, pigment epithelium–derived factor, and thrombospondin 1) in the retinal pigment epithelium–Bruch’s membrane–choriocapillaris complex in the submacular region in aged control eyes and eyes with age-related macular degeneration (AMD). Methods Immunohistochemical analysis with antibodies against endostatin, pigment epithelium–derived factor, and thrombospondin 1 was performed on the macular region of aged control donor eyes (n=8; mean age, 79.8 years) and eyes with AMD (n=12; mean age, 83.9 years). Three independent masked observers scored the reaction product (scored from 0–7). Mean scores from the control eyes and the eyes with AMD were analyzed using 1-way analysis of variance and unpaired t test. Results In control eyes, strong immunoreactivity of all 3 inhibitors was observed in the retinal pigment epithelium–Bruch’s membrane–choriocapillaris complex. Immunoreactivity for endostatin, pigment epithelium–derived factor, and thrombospondin 1 in Bruch’s membrane was significantly lower in eyes with AMD compared with aged control eyes (analysis of variance, P=.003, P = .009, and P< .001, respectively). In the choriocapillaris, a significant reduction was observed in endostatin (analysis of variance, P=.02) and thrombospondin 1 (analysis of variance, P=.005) in eyes with AMD. Conclusions These findings suggest that endogenous angiogenesis inhibitors in the retinal pigment epithelium–Bruch’s membrane–choriocapillaris complex may provide a biochemical barrier for choroidal neovascular invasion. Clinical Relevance Decreased levels of angiogenic inhibitors at the retinal pigment epithelium–Bruch’s membrane–choriocapillaris complex in eyes with AMD make Bruch’s membrane vulnerable to choroidal neovascularization. PMID:18474778

  17. Angiogenesis and Melanoma

    Energy Technology Data Exchange (ETDEWEB)

    Ribatti, Domenico, E-mail: ribatti@anatomia.uniba.it; Annese, Tiziana; Longo, Vito [Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G. Cesare, 11, Policlinico 70124, Bari (Italy)

    2010-02-25

    Angiogenesis occurs in pathological conditions, such as tumors, where a specific critical point in tumor progression is the transition from the avascular to the vascular phase. Tumor angiogenesis depends mainly on the release by neoplastic cells of growth factors specific for endothelial cells, which are able to stimulate the growth of the host’s blood vessels. This article summarizes the literature concerning the relationship between angiogenesis and human melanoma progression. The recent applications of antiangiogenic agents which interfere with melanoma progression are also described.

  18. Study of DNA synthesis and mitotic activity of hepatocytes and its relation to angiogenesis in hepatectomised tumour bearing mice.

    Science.gov (United States)

    Andrini, Laura B; García, Marcela N; Inda, Ana María; Errecalde, Ana Lía

    2013-11-01

    Partial hepatectomy (PH) alters serum concentrations of substances involved in cellular proliferation, leading to the compensatory liver hyperplasia. Furthermore, angiogenesis is mainly stimulated by vascular endothelial growth factor (VEGF) and is a fundamental requirement either in liver regeneration or in tumours growth. This study looks at the expression of VEGF, DNA synthesis (DNAs) and mitotic activity (MA) in hepatectomised (H) and hepatectomised-tumour bearing (HTB) mice throughout a 24 h period. Adult male mice were sacrificed every 4 h from 26 to 50 h post-hepatectomy. H mice show a circadian rhythm in VEGF expression with a maximum value of 2.6 ± 0.1 at 08/46 h of day/hours posthepatectomy (HD/HPH); in DNAs, the maximum value was 3.4 ± 0.3 at 16/30 (HD/HPH) and in MA it was 2.3 ± 0.01 at 12/50 (HD/HPH). In HTB animals the peak of VEGF expression appears at 16/30 (HD/HPH) with a maximum value of 3.7 ± 0.1, the peak of DNAs was at 00/38 (HD/HPH) with a value of 4.6 ± 0.3 and the maximum value of MA of 08/46 (HD/HPH) with a value of 3.01 ± 0.3. We can conclude that the presence of the tumour induces modifications in the intensity and the temporal distribution of the circadian curves of VEGF expression, DNAs and MA of hepatectomised animals. © 2013 International Federation for Cell Biology.

  19. Role of the P38 pathway in calcium silicate cement-induced cell viability and angiogenesis-related proteins of human dental pulp cell in vitro.

    Science.gov (United States)

    Chou, Ming-Yung; Kao, Chia-Tze; Hung, Chi-Jr; Huang, Tsui-Hsien; Huang, Shu-Ching; Shie, Ming-You; Wu, Buor-Chang

    2014-06-01

    This study investigated that calcium silicate (CS) cement may influence the behavior of human dental pulp cells (hDPCs) via mitogen-activated protein kinase pathway, in particular p38. We have addressed that Si ion released from CS cement can influence osmolarity in the medium, which may stimulate hDPC viability and induce angiogenesis-related proteins through stimulation of the nitric oxide synthase and nitric oxide secretion. The hDPCs was cultured with CS cement to angiogenesis. Then, cell viability, ion concentration, osmolality, nitric oxide secretion, the von Willebrand factor, and angiopoietin-1 protein expression were examined. CS cement elicited a significant (P calcium and phosphate ions and released more Si ions in medium. The CS significantly (P < .05) increased the osmolality to 303.52 ± 3.07, 315.03 ± 5.80, and 319.95 ± 4.68 mOsm/kg for 1, 3, and 5 days, respectively. P38 was activated through phosphorylation; the phosphorylation kinase was investigated in our cell system after culture with CS cement. Moreover, expression levels for angiopoietin-1 and von Willebrand factor in hDPCs on CS cement were higher than those of the CS + p38 inhibitor (SB203580) group (P < .05) at all of the analyzed time points. This study showed that CS cement was able to activate the p38 pathway in hDPCs cultured in vitro. Moreover, Si was shown to increase osmolality required to facilitate the angiogenic differentiation of hDPCs via the p38 signaling pathway. When the p38 pathway was blocked by SB203580, the angiogenic-dependent protein secretion was decreased. These findings verified that the p38 pathway plays a key role in regulating the angiogenic behavior of hDPCs cultured on CS cement. Crown Copyright © 2014. Published by Elsevier Inc. All rights reserved.

  20. Mediators of ocular angiogenesis

    Indian Academy of Sciences (India)

    2009-12-31

    Dec 31, 2009 ... changes damage retinal endothelial cells, pericytes, neurons, glia and pigment epithelial cells and recruit inflammatory cells which produce vasoactive compounds, growth factors, coagulation factors and adhesion molecules that eventually leading to angiogenesis and tissue remodelling (Pelikanova.

  1. Plug into PR. NJLA Public Relations Handbook.

    Science.gov (United States)

    New Jersey Library Association, Trenton.

    A guide to using public relations techniques to promote both everyday services and special events at libraries, this handbook describes and suggests ways to use library displays; in-house printing; the local media, e.g., radio spots and cable television; library programs; marketing and promotion; and fundraising, including the formation of a…

  2. School Public Relations: Personnel Roles and Responsibilities

    Science.gov (United States)

    Norton, M. Scott

    2008-01-01

    This article emphasizes the paramount importance of the human resources function in the school system--specifically, in the implementation of an effective school public relations program and in the quality of leadership given by the administrators and the professional and classified staffs. The article submits that school administrators at every…

  3. Principals' Perceptions of School Public Relations

    Science.gov (United States)

    Morris, Robert C.; Chan, Tak Cheung; Patterson, Judith

    2009-01-01

    This study was designed to investigate school principals' perceptions on school public relations in five areas: community demographics, parental involvement, internal and external communications, school council issues, and community resources. Findings indicated that principals' concerns were as follows: rapid population growth, change of…

  4. Outline for an Online Public Relations Program

    Science.gov (United States)

    Schmidt, Janet

    1978-01-01

    Proven public relations strategies for winning management support for information programs and services are discussed, including seeking a higher level of visibility for the library/information center, implementing a current awareness program, and starting an orientation program for new employees. A questionnaire for obtaining user feedback and…

  5. Communications and Public Relations Officer | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Under the supervision of the Regional Director in Nairobi and in contact with the Director, Communications in Ottawa (Canada), the Communications and Public Relations Officer acts as a communications expert, increasing the visibility of the IDRC and its research partners in the Sub-Saharan Africa Region. The incumbent ...

  6. Sport, public relations and social media

    OpenAIRE

    Boyle, Raymond; Haynes, Richard

    2014-01-01

    This chapter examines the disruptive nature of social media as it alters the relationship between sports journalism and public relations. It looks at some key examples and argues that while much is changing, some aspects of the relationship between the media and sports also remain constant.

  7. Cannabidiol inhibits angiogenesis by multiple mechanisms

    Science.gov (United States)

    Solinas, M; Massi, P; Cantelmo, AR; Cattaneo, MG; Cammarota, R; Bartolini, D; Cinquina, V; Valenti, M; Vicentini, LM; Noonan, DM; Albini, A; Parolaro, D

    2012-01-01

    BACKGROUND AND PURPOSE Several studies have demonstrated anti-proliferative and pro-apoptotic actions of cannabinoids on various tumours, together with their anti-angiogenic properties. The non-psychoactive cannabinoid cannabidiol (CBD) effectively inhibits the growth of different types of tumours in vitro and in vivo and down-regulates some pro-angiogenic signals produced by glioma cells. As its anti-angiogenic properties have not been thoroughly investigated to date, and given its very favourable pharmacological and toxicological profile, here, we evaluated the ability of CBD to modulate tumour angiogenesis. EXPERIMENTAL APPROACH Firstly, we evaluated the effect of CBD on human umbilical vein endothelial cell (HUVEC) proliferation and viability – through [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay and FACS analysis – and in vitro motility – both in a classical Boyden chamber test and in a wound-healing assay. We next investigated CBD effects on different angiogenesis-related proteins released by HUVECs, using an angiogenesis array kit and an ELISA directed at MMP2. Then we evaluated its effects on in vitro angiogenesis in treated HUVECs invading a Matrigel layer and in HUVEC spheroids embedded into collagen gels, and further characterized its effects in vivo using a Matrigel sponge model of angiogenesis in C57/BL6 mice. KEY RESULTS CBD induced HUVEC cytostasis without inducing apoptosis, inhibited HUVEC migration, invasion and sprouting in vitro, and angiogenesis in vivo in Matrigel sponges. These effects were associated with the down-modulation of several angiogenesis-related molecules. CONCLUSIONS AND IMPLICATIONS This study reveals that CBD inhibits angiogenesis by multiple mechanisms. Its dual effect on both tumour and endothelial cells supports the hypothesis that CBD has potential as an effective agent in cancer therapy. PMID:22624859

  8. Studi Perbandingan Pemahaman Konsep Public relations Menurut Manajemen dan Staff public Relations Di Mirota Kampus

    OpenAIRE

    SAMODRA, FLORENSIA

    2014-01-01

    Sebuah perusahaan yang bergerak di bidang retail perlu mengkomunikasikan produk yang di jualnya. Oleh karena itu butuh komunikator yang mampu menyampaikan pesan secara kredibel kepada pelangganya. Praktisi public relations merupakan pihak yang bertugas menyampaikan pesan tersebut kepada publiknya. Praktisi public relations menjalankan fungsi manajemen komunikasi antara organisasi dengan publiknya. Agar kegiatan tersebut dapat terlaksana dengan lancer maka butuh dukungan dari pihak manajemen. ...

  9. Standards for Educational Public Relations and Communications Professionals.

    Science.gov (United States)

    Chappelow, Marsha A.

    2003-01-01

    Describes National School Public Relations Association standards for school public relations and communications professionals and program. Includes reactions and comments about new Association standards from seven superintendents and four school public-relations professionals. (PKP)

  10. Public relations jako instrument kreowania wizerunku biblioteki

    Directory of Open Access Journals (Sweden)

    Olesiak Karina

    2016-06-01

    Full Text Available PR are indispensable for creating the positive image of a library and its reliability in the eyes of its users. This article presents the role of public relations in the library, especially image-building internal and external marketing and tools and techniques of communication. The article also describes the activities shaping the image of a library, including Web 2.0 tools.

  11. Public relations ettics: a competetive advangetage

    OpenAIRE

    Šalčiūtė, Irmina

    2010-01-01

    The Public Relations (PR) more are often recognized as a strategy to convince community with something which is useful to the client. Society may find itself being manipulated by such activity. The attitude of society (and client, as a result), towards PR in length of time can influence effectiveness of PR service itself. Ethics is conceived as every individual’s subjective judgement, although ethics can give some additional objective value to PR activity. The object of this master thesis is ...

  12. Analýza public relations na FRRMS

    OpenAIRE

    Rišková, Zuzana

    2014-01-01

    RIŠKOVÁ, Z. Analysis public relations of the FRRMS. Bachelor thesis. Brno, 2014. The bachelor thesis deals with public relations activities of the Faculty of Regional Development and International Studies (FRRMS) Mendel University in Brno (MENDELU). The aim of the thesis is to analyze public relations activities, what relations has FRRMS with the public. In the theoretical part is defined the meaning of the public relations, goals, starting points, tools and forms of public relations and the ...

  13. Public relations i et overkommunikeret samfund

    Directory of Open Access Journals (Sweden)

    Jesper Højbjerg Christensen

    1993-09-01

    Full Text Available Vi har aldrig før været så overfodret med kommunikation. Jesper Højbjerg Christensen, direktør for Advice Ledelses- og Kommuni- kationsrådgivning A/S, diskuterer i artiklen som praktiker med kom- munikationsreoretisk baggrund, hvordan det kan sikres, at man inden for kommunikations- og public relations-branchen ikke bare kommunikerer som propagandamaskiner - mere og mere - men hellere går i dialog og kommunikerer mindre, og bedre. Han peger på, at vi i fremtiden, bl.a. takket være sammenhængne mellem høj uddannelse og avanceret teknologi, får mulighed for at udfolde mere symmetriske kommunikationsformer og konsensus-funderet dialog. Som sit bidrag til at udrydde forvirringen om, hvad public relation egentlig er, opstiller han - uden større tiltro til, at man kan skabe en "teori" om PR - ud fra praksis fire forskellige måder at dyrke public relations på.

  14. Public confidence, risk communication and public relations. Oeffentliches Vertrauen, Risikokommunikation und Public Relations

    Energy Technology Data Exchange (ETDEWEB)

    Bentele, G. (Univ. Bamberg, Fakultaet Sprach- und Literaturwissenschaften-Kommunikationswissenschaft (Germany))

    1992-07-27

    In information societies, by far the greatest part of the information obtained and used by the public comes via the media. At the same time, only a minute portion of information used can be verified by an individual. Therefore the confidence factor gains increasing importance. This applies, particularly, to production and service sectors, which are associated with a certain risk (for instance, nuclear energy and coal). Lately, large confidence deficits have arisen - not only entailing economic drawbacks and damaging images but jeopardizing, moreover, democratic structures. Changing structures of public communication in information societies result in changed demands on corporate communication. The author points out what is needed especially in the energy sector to preserve in the long run, or regain, public confidence. (orig.).

  15. How phototherapy affects angiogenesis

    Science.gov (United States)

    Dyson, Mary

    2007-02-01

    Angiogenesis is essential for normal growth, tissue repair and regeneration. Its stimulation accelerates repair and regeneration including wound healing where these processes are delayed. Its inhibition can reduce the rate of growth of solid tumors. Phototherapy can accelerate the resolution of acute inflammation with the result that the proliferative phase of tissue repair, when angiogenesis occurs, begins earlier than in sham-irradiated controls. Evidence that angiogenesis is enhanced in dermal repair, tendon repair and bone regeneration in rodents is presented. The cellular mechanisms that control angiogenesis involve the interaction of endothelial cells, macrophages, pericytes and other cells in response, for example, to changes in the availability of oxygen in the local environment. Pericytes and macrophages modulate endothelial cell proliferation; pericytes guide endothelial cell migration. The stimulation of endothelial cell proliferation in vitro following exposure to red (660 nm) and infrared (820 nm) radiation, 15 mW, at 2-8 J/cm2 is presented. 1J/cm2 was ineffective. 820 nm irradiation, 15 mW, at 8 J/cm2 was observed to inhibit pericyte proliferation in vitro. Indirect effects on endothelial cell and pericyte proliferation followed stimulation of soluble mediator production by macrophages following exposure to red and infrared radiation. The potential clinical significance of the results obtained is discussed and the necessity of clinical trials emphasized.

  16. Public Relations between Occupation and Profession – Attempts at Regulating Public Relations

    Directory of Open Access Journals (Sweden)

    Božo Skoko

    2012-06-01

    Full Text Available This paper is concerned with the regulation and the professionalization of occupations in public relations. It analyzes the role of professional, national associations in the professionalization process, providing an overview of these organizations in various countries around the world. The authors identify countries with no regulation (for instance, Italy, countries with some legal regulations (for instance, Brazil and countries that have adopted self-regulation models (for instance, USA and South Africa. The authors point out the advantages and drawbacks of each regulation model and their impact on the development and professionalization of the occupation. Namely, in countries in which public relations are defined by law, public relations experts have guaranteed positions in society; however, they enjoy a negative public perception. In self-regulatory models, a significant number of experts are not covered by membership in organizations. Consequently, their behavior is not governed by any set of established professional obligations. Furthermore, countries with no clear professional regulation have enabled mass engagement in public relations; however, there are no criteria for professional advancement and affirmation. The issue of regulation in transition countries has shown itself to be a relatively unarticulated concept that can be expected to acquire greater definition with further professionalization of the occupation, a key role that must be played by professional associations.

  17. Evolutionary understanding of the concept "Public relations"

    OpenAIRE

    Кам’янецька, О.В.

    2013-01-01

    The considered approaches to determination of notion of «public relations» different research and practical workers. The analyzed stages of development of communications with public and described their signs. Розглянуті підходи до визначення поняття «паблік рілейшнз» різних науковців та практиків. Проаналізовані етапи розвитку підходів до зв’язків з громадськістю та охарактеризовані їх ознаки....

  18. Student-Created Public Relations for Gifted Education.

    Science.gov (United States)

    Bisland, Amy

    2003-01-01

    This article discusses the benefits of student participation in a gifted public relations campaign, including creating public support for gifted programming and developing leadership skills. Steps for developing a formal unit of instruction on public relations are described, along with ideas for public relations activities. (Contains references.)…

  19. Interdiscursive collaboration in public relations contexts

    Directory of Open Access Journals (Sweden)

    Vijay K. Bhatia

    2013-04-01

    Full Text Available Interdiscursive collaborative construction of professional genres (Bhatia, 2004 & 2010; Bremner, 2006; Smart, 2006 within the framework of “communities of practice” (Lave & Wenger, 1991 can be viewed as a useful instrument for developing writing expertise to initiate novice writers into the conventions of corporate writing. Drawing on evidence from public relations (PR writing contexts in Hong Kong, the paper focuses on the dynamics of participation in collaborative PR practice and on the deconstruction of the collaborative process as evidenced in the deconstruction of various drafts (from brainstorming to the final product and through the perceptions of some of the key PR practitioners in the industry. The paper will have implications for our understanding of interdiscursivity in genre theory (Bhatia, 2010 and for the collaborative writing process within the academy as well as in the workplace.

  20. Vascular grading of angiogenesis

    DEFF Research Database (Denmark)

    Hansen, S; Grabau, D A; Sørensen, Flemming Brandt

    2000-01-01

    The study aimed to evaluate the prognostic value of angiogenesis by vascular grading of primary breast tumours, and to evaluate the prognostic impact of adding the vascular grade to the Nottingham Prognostic Index (NPI). The investigation included 836 patients. The median follow-up time was 11...... was moderately reproduced (kappa = 0.59). Vascular grade was significantly associated with axillary node involvement, tumour size, malignancy grade, oestrogen receptor status and histological type. In univariate analyses vascular grade significantly predicted recurrence free survival and overall survival for all...... impact for 24% of the patients, who had a shift in prognostic group, as compared to NPI, and implied a better prognostic dissemination. We concluded that the angiogenesis determined by vascular grading has independent prognostic value of clinical relevance for patients with breast cancer....

  1. Integrating Public Relations with Advertising: An Exercise for Students in the College Public Relations Campaigns Course

    Science.gov (United States)

    Moody, Reginald Ford

    2012-01-01

    Today's public relations (PR) campaigns courses give students the opportunity to research, analyze, plan, and, in many cases, execute a campaign for a real client. Even so, today's campaigns courses may leave students with a weak understanding of how PR can best partner with other tools in the communication mix, namely advertising. Educators may…

  2. Perlecan and tumor angiogenesis

    DEFF Research Database (Denmark)

    Jiang, Xinnong; Couchman, John R

    2003-01-01

    Perlecan is a major heparan sulfate proteoglycan (HSPG) of basement membranes (BMs) and connective tissues. The core protein of perlecan is divided into five domains based on sequence homology to other known proteins. Commonly, the N-terminal domain I of mammalian perlecan is substituted with thr...... have unwanted promoting effects on tumor cell proliferation and tumor angiogenesis. Understanding of these attributes at the molecular level may offer opportunities for therapeutic intervention....

  3. A Disciplinary Perspective: The Internationalization of Australian Public Relations Education

    Science.gov (United States)

    Fitch, Kate

    2013-01-01

    This article investigates the internationalization of public relations education, by examining public relations education in Australia, its relation with the public relations industry, and its growth in response to international student- and market-led demand. The discussion highlights the tensions within what is essentially an education project…

  4. Teaching International Public Relations: An Update Report among Educators

    Science.gov (United States)

    Mak, Angela Ka Ying

    2017-01-01

    Involvement in international and multicultural career-related practices is ever on the rise in a global economic and political society, especially in public relations. This article reported an update of examining the attributes of public relations educators and their institutions in teaching of international public relations (IPR) through an…

  5. Introducing Edward L. Bernays, the "Father of Public Relations."

    Science.gov (United States)

    Yeager, Robert J.

    1985-01-01

    Relates some of the public relations achievements and techniques of Edward L. Bernays. Sees modern public relations proceeding from an understanding of individuals, institutions and social groups, and their interrelationships. Considers the information dissemination, persuasion, and attitude integration functions of public relations. Lists…

  6. Prostaglandin F2alpha differentially affects mRNA expression relating to angiogenesis, vasoactivation and prostaglandins in the early and mid corpus luteum in the cow.

    Science.gov (United States)

    Shirasuna, Koumei; Sasahara, Kiemi; Matsui, Motozumi; Shimizu, Takashi; Miyamoto, Akio

    2010-08-01

    Administration of prostaglandin (PG) F(2alpha) in cattle during the mid-luteal phase (Days 8-12 of the estrous cycle) drastically reduces the plasma progesterone concentrations and the volume of the corpus luteum (CL). However, PGF(2alpha) does not induce luteolysis during the early luteal phase (up to Day 5 of the estrous cycle). To characterize the possible distinct difference in acute response to a luteolytic dose of PGF(2alpha) administration, we determined various mRNA expressions in the early and mid CL relating to angiogenesis, vasoactivation and PG-related factors at 30 min after PGF(2alpha) injection in cyclic cows. The experiments were conducted on Day 4 (early CL) and Days 10-12 (mid CL). Cows were either injected with 500 microg PGF(2alpha) analogue or saline as the control (early CL control, n=5; early CL PGF(2alpha) treated, n=5; mid CL control, n=5; mid CL PGF(2alpha) treated, n=7). Thirty min after injection of PGF(2alpha) or saline, the cows were ovariectomized transvaginally, and the CL tissues were collected from regions designated as the periphery and center of the CL. Administration of PGF(2alpha) up-regulated the mRNA expressions of angiogenic-related factors such as vascular endothelial growth factors, vasohibin, fibroblast growth factor 2 and insulin-like growth factor-II in the early CL, whereas PGF(2alpha) down-regulated these mRNA expressions in the mid CL. In the vasoactive factors, PGF(2alpha) stimulated the mRNA expressions of endothelin-1, angiotensin converting enzyme, endothelial nitric oxide synthase (NOS) and inducible NOS in the periphery area of the mid CL, but not in the early CL. However, PGF(2alpha) drastically down-regulated PGF(2alpha) receptor mRNA expression in both regions of the early and mid CL. The results indicated a clear difference in the acute action of PGF(2alpha) depending not only on the luteal phase (immature vs. mature) but also the region (periphery vs. center) within the CL at 30 min after PGF(2alpha

  7. Development and implementation of public relations strategy

    International Nuclear Information System (INIS)

    Kukovica, T.; Mele, I.; Stritar, A.; Isteni, R.

    1995-01-01

    Following the strong public opposition after the announcement of the results of possible site selections for the final low and intermediate waste repository in Slovenia in 1993, the Agency for Radwaste Management has completely revised its public information strategy. The information and education programs, that should lead to greater public acceptance, are described. At present the bulletin, leaflets, booklet, permanent exhibition and lectures in the Nuclear Training Centre are applied. (author)

  8. Nuclear energy: strategy of public relations

    International Nuclear Information System (INIS)

    Timell, S.

    1981-01-01

    A referendum was held in Sweden on 23rd March 1980, stimulated by the Three Mile Island accident in USA, to determine the future nuclear power development policy. The electricity supply background is that in 1980, 65% of power was hydro, 25% nuclear and 10% coal and oil. In terms of total power consumption, the country is heavily dependent on oil, which represents about 75%. The intensive public relations activity previous to the referendum is described, and this involved fact accumulation and assimilation, dissemination through various media, including brochures, displays, films and leaflets. In the political arena three lines developed: (1) (Conservatives); continue nuclear power, building at least 12 reactors, (2) (Social democrats and liberals); similar to (1), but more cautious, with emphasis on energy conservation, (3) (Centre parties and communists); no more nuclear power, and prevention of uranium extraction in Sweden. The voting was (1) 18.9%, (2) 39.1%, (3) 38.7%, (No decision) 3.3%. (G.C.)

  9. The usage of the public relations tools in the public relations strategy of the company "Prakse.lv"

    OpenAIRE

    Uzula, Iveta

    2012-01-01

    The bachelor thesis is done to reveal strengths and weaknesses of the public relations of the company „Prakse.lv” by exploring the public relations tools of the public relations strategy. The aim of the research is to find out the most effective public relations tools for the communicative development of the company „Prakse.lv” by exploring the public relations tools used in the public relations strategy of the company. The theorethical part of the research is based on the ex...

  10. Vaccinations: A public health triumph and a public relations tragedy.

    Science.gov (United States)

    Jacobson, Robert M

    2012-08-01

    Routine vaccination has been hailed as one of the top public health achievements of the last century. However, despite the reduced number of cases of and deaths from vaccine-preventable diseases such as pertussis and measles, outbreaks continue to occur as more parents fail to adequately vaccinate their children because of misinformation about immunizations. This article describes the challenges of making sure all children in the United States are fully immunized and what physicians need to know to effectively work with parents who may be hesitant to vaccinate their children.

  11. Intercultural Interpretations: Making Public Relations Education Culturally Relevant

    Science.gov (United States)

    Chia, Joy

    2009-01-01

    Public relations educators delivering courses to international students find that each cohort of students interprets and understands public relations theory and its application to practice according to their respective cultures. The premise of this paper is to reflect on some of the interpretations and expectations of public relations students…

  12. State of the Art of International Public Relations Education.

    Science.gov (United States)

    Wakefield, Gay; And Others

    To examine aspects of the political/economic/social/cultural environments (PESCE) affecting international public relations and their significance to the future of public relations practitioners, this paper reviews the 1980s literature regarding the current and projected trends in international public relations practice and their implications for…

  13. Challenging Assumptions of International Public Relations: When Government Is the Most Important Public.

    Science.gov (United States)

    Taylor, Maureen; Kent, Michael L.

    1999-01-01

    Explores assumptions underlying Malaysia's and the United States' public-relations practice. Finds many assumptions guiding Western theories and practices are not applicable to other countries. Examines the assumption that the practice of public relations targets a variety of key organizational publics. Advances international public-relations…

  14. Using public relations to promote health: a framing analysis of public relations strategies among health associations.

    Science.gov (United States)

    Park, Hyojung; Reber, Bryan H

    2010-01-01

    This study explored health organizations' public relations efforts to frame health issues through their press releases. Content analysis of 316 press releases from three health organizations-the American Heart Association, the American Cancer Society, and the American Diabetes Association-revealed that they used the medical research frame most frequently and emphasized societal responsibility for health issues. There were differences, however, among the organizations regarding the main frames and health issues: the American Diabetes Association was more likely to focus on the issues related to social support and education, while the American Heart Association and the American Cancer Society were more likely to address medical research and scientific news. To demonstrate their initiatives for public health, all the organizations employed the social support/educational frame most frequently. Researchers and medical doctors frequently were quoted as trusted sources in the releases.

  15. Public relations and the radiation processing industry

    Science.gov (United States)

    Coates, T. Donna

    The world's uneasiness and mistrust regarding anything nuclear has heightened in recent years due to events such as Chernobyl and Three Mile Island. Opinion polls and attitude surveys document the public's growing concern about issues such as the depletion of the ozone layer, the resulting greenhouse effect and exposure of our planet to cosmic radiation. Ultimately, such research reveals an underlying fear regarding the unseen impacts of modern technology on the environment and on human health. These concerns have obvious implications for the radiation processing industry, whose technology is nuclear based and not easily understood by the public. We have already seen organized nuclear opponents mobilize public anxiety, fear and misunderstanding in order to oppose the installation of radiation processing facilities and applications such as food irradiation. These opponents will no doubt try to strengthen resistance to our technology in the future. Opponents will attempt to convince the public that the risks to public and personal health and safety outweigh the benefits of our technology. We in the industry must head off any tendency for the public to see us as the "enemy". Our challenge is to counter public uneasiness and misunderstanding by effectively communicating the human benefits of our technology. Clearly it is a challenge we cannot afford to ignore.

  16. Public relations and the radiation processing industry

    Energy Technology Data Exchange (ETDEWEB)

    Coates, T.D. (Nordion International Inc., Kanata, Ontario (Canada))

    1990-01-01

    The world's uneasiness and mistrust regarding anything nuclear has heightened in recent years due to events such as Chernobyl and Three Mile Island. Opinion polls and attitude surveys document the public's growing concern about issues such as the depletion of the ozone layer, the resulting greenhouse effect and exposure of our planet to cosmic radiation. Ultimately, such research reveals an underlying fear regarding the unseen impacts of modern technology on the environment and on human health. These concerns have obvious implications for the radiation processing industry, whose technology is nuclear based and not easily understood by the public. We have already seen organized nuclear opponents mobilize public anxiety, fear and misunderstanding in order to oppose the installation of radiation processing facilities and applications such as food irradiation. These opponents will no doubt try to strengthen resistance to our technology in the future. Opponents will attempt to convince the public that the risks to public and personal health and safety outweigh the benefits of our technology. We in the industry must head off any tendency for the public to see us as the ''enemy''. Our challenge is to counter public uneasiness and misunderstanding by effectively communicating the human benefits of our technology. (author).

  17. Public education and media relations in psychology.

    Science.gov (United States)

    Wedding, Danny

    2017-11-01

    This article reviews psychology's attempts to influence public attitudes about both the science and the profession of psychology. The early history of the profession is reviewed, and the efforts of the American Psychological Association (APA) to shape the public's perception of psychology are discussed. The rise of social media is reviewed, and important social media outlets relevant to psychology are identified. The activities of the Society for Media Psychology and Technology (APA Division 46) are illustrated, and the presidents of the Division are identified. The work of those psychologists who are noted public intellectuals or who have received Nobel prizes or National Medal of Science awards for their research is briefly reviewed, and the public notoriety of 4 prominent media celebrities (Joy Browne, Joyce Brothers, Laura Schlessinger, and Phil McGraw) is discussed. Several controversies in the field of psychology that have influenced the public and their attitudes about psychology are also briefly reviewed. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  18. Public Relations vs. Legal Strategies in Organizational Crisis Decisions.

    Science.gov (United States)

    Fitzpatrick, Kathy R.; Rubin, Maureen Shubow

    1995-01-01

    Finds that in almost two-thirds of the cases studied, in which organizations responded to public charges of sexual harassment, legal strategy--rather than public relations strategy--was used by official spokespersons. Argues that organizations need to reconcile the often contradictory counsel of public relations and legal professionals. (SR)

  19. Influence of Public Relations and Reference Services on Academic ...

    African Journals Online (AJOL)

    in academic institutions includes among others: reference services, public relation services, lending services, user ... public. Public relations counsel the practitioner in the field, advises his library boss on his attitudes and conduct needed to achieve social objectives. .... found helpful, then national or international resources ...

  20. The role of public relations activities in hospital choice.

    Science.gov (United States)

    Tengilimoglu, Dilaver; Yesiltas, Mehmet; Kisa, Adnan; Dziegielewski, Sophia F

    2007-01-01

    Public relations activities for all organizations can have an important effect on consumer decision-making when buying goods or services. This study examines the effect that public relations activities can have regarding consumer decisions and choice. To explore exemplify this relationship a questionnaire was given to 971 patients within public, university and private hospitals in Ankara, Turkey. Study results show that public relations activities were a crucial factor in determining consumer hospital choice. The majority of respondents reported that the behaviors and attitude of personnel as public relations activities that support the hospital's reputation within the public were the primary variables in hospital choice. Health care managers can use these findings to further understand how patients make informed choices related to usage of a health care facility and to develop and/or improve public relations activities.

  1. The environment, public relations and coal

    Energy Technology Data Exchange (ETDEWEB)

    Wood, W.J. (Coal Association of Canada, Calgary, AB (Canada))

    1990-09-01

    Information is presented in note format. The presentation covers world environmental issues such as the greenhouse effect, an overview of the coal industry's role in atmospheric emissions of CO{sub 2}, and finally, the need for the coal industry to make the public aware of coal's current and future role in our economic and energy future.

  2. Public relations and public understanding in the nuclear industry in Europe

    Energy Technology Data Exchange (ETDEWEB)

    Roos, E.; Michel, A. [Belgonucleaire, Brussels (Belgium)

    1995-12-31

    Before talking about public understanding and public relations in the nuclear industry in Europe, a word about the mosaic structure of the European energy policy and public is required because a similar structure will be found in the European public understanding policy. Afterwards, we explain what communications tools are available and how the different European countries apply them.

  3. Rising stakeholder expectations and the changing role of public relations

    Energy Technology Data Exchange (ETDEWEB)

    Grossberndt, D. [BP Canada Energy Company, Calgary, AB (Canada)

    2004-07-01

    The role of public relations is changing along with growing public awareness of stakeholder's ability to intervene in the development of energy projects. Public relations and community consultation departments must work closely together to ensure that consistent messages are being delivered to the public. This presentation explained how to develop a successful public relations strategy ranging from environmental risk assessment to community consultation. It also discussed the degree to which effective and ongoing communication with stakeholders prevents opposition and negative media coverage.

  4. Diabetes and Wound Angiogenesis

    Science.gov (United States)

    Okonkwo, Uzoagu A.; DiPietro, Luisa A.

    2017-01-01

    Diabetes Mellitus Type II (DM2) is a growing international health concern with no end in sight. Complications of DM2 involve a myriad of comorbidities including the serious complications of poor wound healing, chronic ulceration, and resultant limb amputation. In skin wound healing, which has definite, orderly phases, diabetes leads to improper function at all stages. While the etiology of chronic, non-healing diabetic wounds is multi-faceted, the progression to a non-healing phenotype is closely linked to poor vascular networks. This review focuses on diabetic wound healing, paying special attention to the aberrations that have been described in the proliferative, remodeling, and maturation phases of wound angiogenesis. Additionally, this review considers therapeutics that may offer promise to better wound healing outcomes. PMID:28671607

  5. Angiogenesis and Endometriosis

    Directory of Open Access Journals (Sweden)

    Ana Luiza L. Rocha

    2013-01-01

    Full Text Available A comprehensive review was performed to survey the role of angiogenesis in the pathogenesis of endometriosis. This is a multifactorial disease in which the development and maintenance of endometriotic implants depend on their invasive capacity and angiogenic potential. The peritoneal fluid of patients with endometriosis is a complex suspension carrying inflammatory cytokines, growth factors, steroid hormones, proangiogenic factors, macrophages, and endometrial and red blood cells. These cells and their signaling products concur to promote the spreading of new blood vessels at the endometriotic lesions and surroundings, which contributes to the endometriotic implant survival. Experimental studies of several antiangiogenic agents demonstrated the regression of endometriotic lesions by reducing their blood supply. Further studies are necessary before these novel agents can be introduced into clinical practice, in particular the establishment of the safety of anti-angiogenic medications in women who are seeking to become pregnant.

  6. Angiogenesis in gliomas.

    Directory of Open Access Journals (Sweden)

    Elzbieta Czykier

    2008-02-01

    Full Text Available Brain gliomas are characterized by invasive growth and neovascularisation potential. Angiogenesis plays a major role in the progression of gliomas and its determination has a great prognostic value. The aim of the study was to assess the vascularisation of chosen brain gliomas and to estimate how it is correlated with tumour histological type, malignancy grade, location and size, and with age and sex of patients. Tumour vascularisation analysis was based on the determination of microvascular proliferation (MVP and microvessel density (MVD. Microvascular proliferation was measured with immunohistochemical methods using mouse monoclonal antibodies to detect cell proliferation antigens. The following antibodies were used Ki-67 and PCNA (DAKO. Identification of vessels was performed by CD31 antibody and anti-human von Willebrand factor (DAKO. The highest microvascular proliferation and microvascular density were observed in multiform glioblastomas and the lowest in oligodendrogliomas. Significant correlation was observed between the vascularisation and malignancy grade.

  7. The Practices and Challenges of Public Relations within Two ...

    African Journals Online (AJOL)

    Prof

    Public Relations and Marketing function together by building exchange relationships with consumers, customers, clients, distributors, and other marketing parties through areas such as sponsorships, corporate identity, image building and media relations (Kotler et al., 2005). In Ethiopia, where the public relations practice is ...

  8. Social Media, Traditional Media and Marketing Communication of Public Relations

    DEFF Research Database (Denmark)

    Khajeheian, Datis; Mirahmadi, Fereshteh

    2015-01-01

    Public relations are undertaking more important role in the marketing communication and advertising. The present paper reports a survey conducted in three Iranian banks’ public relations departments to understand how they use different media in their marketing communications and other related...

  9. Angiogenesis Inhibitors in NSCLC

    Directory of Open Access Journals (Sweden)

    Anna Manzo

    2017-09-01

    Full Text Available Angiogenesis is a complex biological process that plays a relevant role in sustaining the microenvironment, growth, and metastatic potential of several tumors, including non-small cell lung cancer (NSCLC. Bevacizumab was the first angiogenesis inhibitor approved for the treatment of patients with advanced NSCLC in combination with chemotherapy; however, it was limited to patients with non-squamous histology and first-line setting. Approval was based on the results of two phase III trials (ECOG4599 and AVAIL that demonstrated an improvement of about two months in progression-free survival (PFS in both trials, and in the ECOG4599 trial, an improvement in overall survival (OS also. Afterwards, other antiangiogenic agents, including sunitinib, sorafenib, and vandetanib have been unsuccessfully tested in first and successive lines. Recently, two new antiangiogenic agents (ramucirumab and nintedanib produced a significant survival benefit in second-line setting. In the REVEL study, ramucirumab plus docetaxel prolonged the median OS of patients with any histology NSCLC when compared with docetaxel alone (10.4 versus 9.1 months, hazard ratio (HR 0.857, p = 0.0235. In the LUME-Lung 1 study, nintedanib plus docetaxel prolonged the median PFS of patients with any tumor histology (p = 0.0019, and improved OS (12.6 versus 10.3 months in patients with adenocarcinoma. As a result, it became a new option for the second-line treatment of patients with advanced NSCLC and adenocarcinoma histology. Identifying predictive biomarkers to optimize the benefit of antiangiogenic drugs remains an ongoing challenge.

  10. Research on the crisis of public relation in library

    International Nuclear Information System (INIS)

    Liu Shanyong

    2010-01-01

    In modem society, a variety of organizations including libraries will inevitably encounter all kinds of crises. Organizations can pull through and create good impression if they deal with correctly the crisis of public relation. The article defines the crisis, the crisis of public relation, and analyzes the characteristics and types of the crises in library. Finally the article emphasizes the contents and six strategies of the crisis of public relation in library. (authors)

  11. Public relations and journalism: truth, trust, transparency and integrity

    OpenAIRE

    Davies, Frank

    2008-01-01

    Truth, trust, integrity and reputation are key concepts for understanding the relationship between journalists and public relations practitioners. This the paper: first, considers the current debate on the inter-relationship between journalism and public relations; second distinguishes varieties of public relations and journalism; third, analyses the Editorial Intelligence controversy; fourth, deconstructs aspects of "truth" and "trust" in the context of that debate; fifth, considers why the ...

  12. Public Relations and Propaganda: Restrictions on Executive Agency Activities

    National Research Council Canada - National Science Library

    Kosar, Kevin R

    2005-01-01

    Controversies recently have arisen over certain executive branch agencies' expenditures of appropriated funds on public relations activities, some of which have been characterized as propagandistic...

  13. Public Relations on Fusion in Europe

    Science.gov (United States)

    Ongena, J.; van Oost, G.; Paris, P. J.

    2000-10-01

    A summary will be presented of PR efforts on fusion energy research in Europe. A 3-D movie of a fusion research experimental reactor has been realized at the start of this year. It has been made entirely on virtual animation basis. Two versions exists, a short version of 3 min., as a video clip, and a longer version of nearly 8 min. Both could be viewed in 3D, using special projections and passive glasses or in normal VHS video projections. A new CD-ROM for individual and classroom use will be presented, discussing (i) the different energy forms, (ii) general principles of fusion, (iii) current research efforts and (iv) future prospects of fusion. This CD-ROM is now produced in English, German, French, Spanish, Italian and Portuguese Several new brochures and leaflets intended to increase the public awareness on fusion in Europe will be on display.

  14. Public relations and the Chernobyl accident

    International Nuclear Information System (INIS)

    Hill, P.; Hille, R.; Paschke, M.; Schneider, K.; Uray, I.

    1998-01-01

    In 1991-1993, a large-scale measuring programme was carried out in Germany to assess the radiation burden of the population in regions polluted due to the Chernobyl accident. The primary goal was to objectively inform the population about their actual radiation exposure, to reduce unjustified fears, and to enable countermeasures to be taken where appropriate. A comprehensive overview of the radiation situation was thus also obtained in the regions examined. Channels were sought and found in order to communicate with the more than 250 000 individuals involved in the programme as well as with scientific institutions and the public. Direct communication of the results to the persons examined by means of a certificate including a short explanation proved to be essential to create an atmosphere of trust. (P.A.)

  15. Therapeutic angiogenesis for cardiovascular disease

    Directory of Open Access Journals (Sweden)

    D'Amore Patricia A

    2001-10-01

    Full Text Available Abstract The identification of angiogenic growth factors, such as vascular endothelial growth factor and fibroblast growth factor, has fueled interest in using such factors to induce therapeutic angiogenesis. The results of numerous animal studies and clinical trials have offered promise for new treatment strategies for various ischemic diseases. Increased understanding of the cellular and molecular biology of vessel growth has, however, prompted investigators and clinicians alike to reconsider the complexity of therapeutic angiogenesis. The realization that formation of a stable vessel is a complex, multistep process may provide useful insights into the design of the next generation of angiogenesis therapy.

  16. Notary public authority in marital/partnership relations

    Directory of Open Access Journals (Sweden)

    Kovaček-Stanić Gordana

    2012-01-01

    Full Text Available In Serbian legislation notary public profession is introduced recently, enacting the Act on Public Notary 2011. Notary public has existed in Serbia before World War II, but after the War this profession ceased to exist, as it was not regulated by law. In this article author discusses issue of the public notary authority in marital/partnership relations. Public notary has authority in property relations and support. Regarding property relations, according to the Act on Notary Public, agreement on division of the community of property might be concluded in specific notarial form. In addition, nuptial agreements (pre nuptial or antenuptial might be concluded in specific notarial form. The same is applied to the partners agreements if partners live in heterosexual nonmarital cohabitation, regulated by Family Act. Regarding support, public notary has authority to issue agreements on support. It is important to stress that in Serbian family law waiving the right to support has no legal bearing.

  17. Public Relations & Media Relations (Kritik Budaya Amplop Pada Media Relations Institusi Pendidikan Di Yogyakarta

    Directory of Open Access Journals (Sweden)

    Adhianty Nurjanah

    2015-07-01

    Full Text Available This research is aims to determine how the media relations activities that have been done 10 Public Relations Higher Education, including the possibility of granting cultural envelope in media relations activities during this do. The object of this study is ten (10 Universities in Yogyakarta that consists of three (3 State University (PTN and seven (7 Colleges (PTS. Variations and types of media relations activities have been conducted by 10 universities. The reason is because the electoral college to ten (10 college is a big college in the city of Yogyakarta who own Public Relations and media relations activities that have a systematic and well-planned. In the course of media relations, Public Relations universities do culture accepting envelopes to reporters on the grounds reimburse the costs of transport and not as a "bribe" so that they publicized the news and as a means of imaging the institution. Publicist colleges feel that culture provides envelopes to reporters did not violate the code of ethics of their profession as a Public Relations, On the other hand for journalists, cultural granting envelope can interfere with the independence and constitute a violation of the code of ethics of their profession as journalists. Yet there are also journalists who will receive an envelope in their reporting activities. The discrepancies in the implementation of the code of ethics of journalism, is strongly influenced by the integrity of journalists and policies that apply to each media institution. Penelitian ini bertujuan untuk mengetahui bagaimana kegiatan media relations yang telah dilakukan 10 Public Relations / Humas Perguruan Tinggi tersebut, termasuk kemungkinan adanya budaya pemberian amplop dalam kegiatan media relations yang selama ini dilakukan. Objek penelitian ini adalah sepuluh (10 Perguruan Tinggi di Yogyakarta yang terdiri dari tiga (3 Perguruan Tinggi Negeri (PTN dan tujuh (7 Perguruan Tinggi Swasta (PTS . Beragam variasi dan jenis

  18. Ethics of the profession of public relations--does the public relations affects on journalism in Croatia?

    Science.gov (United States)

    Tanta, Ivan; Lesinger, Gordana

    2013-09-01

    The UK's leading professional body for public relations "Chartered Institute of Public Relations" (CIPR) said that the public relations is about reputation--they are the result of what you do, what you say and what others say about you. Furthermore CIPR says that public relations are discipline whose objectives are safeguarding reputation, establishing understanding and pot pores, and the impact on the thinking and behavior of the public. Although the primary goal of public relations is to preserve and build a reputation, to tell the truth to a customer who has hired experts in this area, it seems that in its own way of development, public relations practitioners have stopped worrying about their reputation and the perception of the discipline within the public they address. All relevant professional bodies for public relations, including the Croatian Association for Public Relation (HUOJ), had set up codes of ethics and high standards according which the members and practitioners should be evaluated. Among other things stays that practitioner of public relations is required to check the reliability and accuracy of the data prior to their distribution and nurture honesty and accountability to the public interest. It seems that right this instruction of code of ethics has been often violated. In a public speech in Croatia, and therefore in the media, exist manipulation, propaganda, and all the techniques of spin, which practitioners of public relations are skillfully using in the daily transfer of information to the users and target groups. The aim of this paper is to determine what is the perception of the profession to the public. As in today's journalism increasingly present plume of public relations, we wish to comment on the part where journalism ends and begins PR and vice versa. In this paper, we analyze and compare codes of ethics ethics associations for public relations, as well as codes of ethics journalists' associations, in order to answer the question

  19. Some aspects of public relation activities at Russian NPPs

    International Nuclear Information System (INIS)

    Ermakov, Sergei

    1995-01-01

    Full text: Since 1992 Rosenergoatom has managed most of the Russian NPPs. Here in this report we present its main public relations activities. 1. The leading role of the management of Rosenergoatom (Direction of Public Relations) is in relations with the public. 2. The main public relations activities are: - contact with the selected and administrative authorities of different levels, - interaction with mass media, - information of employees, - information of, and interaction with, the people of the areas close to the NPPs and especially of the nearby towns, - organising and carrying out opinion polls, - celebration campaigns at NPPs. 3. The use of NPPs' information centers and groups for PR activities: - construction and equipping of NPPs' public information centers; organising excursions, lectures, debates at NPPs; - publishing of news papers at NPPs and at NPPs' towns. 4. Public information in the regions close to the NPPs construction sites (Far East, Kostroma, Rostov, Veronezh regions). 5. Conclusions on the activities and plans for the future. (author)

  20. Approaches to organizing public relations functions in healthcare.

    Science.gov (United States)

    Guy, Bonnie; Williams, David R; Aldridge, Alicia; Roggenkamp, Susan D

    2007-01-01

    This article provides health care audiences with a framework for understanding different perspectives of the role and functions of public relations in healthcare organizations and the resultant alternatives for organizing and enacting public relations functions. Using an example of a current issue receiving much attention in US healthcare (improving rates of organ donation), the article provides examples of how these different perspectives influence public relations goals and objectives, definitions of 'public', activities undertaken, who undertakes them and where they fit into the organizational hierarchy.

  1. Angiogenesis and Its Therapeutic Opportunities

    Directory of Open Access Journals (Sweden)

    So Young Yoo

    2013-01-01

    Full Text Available Angiogenesis plays critical roles in human physiology that range from reproduction and fetal growth to wound healing and tissue repair. The sophisticated multistep process is tightly regulated in a spatial and temporal manner by “on-off switch signals” between angiogenic factors, extracellular matrix components, and endothelial cells. Uncontrolled angiogenesis may lead to several angiogenic disorders, including vascular insufficiency (myocardial or critical limb ischemia and vascular overgrowth (hemangiomas, vascularized tumors, and retinopathies. Thus, numerous therapeutic opportunities can be envisaged through the successful understanding and subsequent manipulation of angiogenesis. Here, we review the clinical implications of angiogenesis and discuss pro- and antiangiogenic agents that offer potential therapy for cancer and other angiogenic diseases.

  2. Angiogenesis Regulates Prostate Cancer Metastasis

    National Research Council Canada - National Science Library

    Pettaway, Curtis

    1999-01-01

    .... We are evaluating the relationship of the expression of the angiogenesis factors bFGF, VEGF, and IL-8 with prostate cancer growth and metastasis, using our orthotopic model of metastatic prostate cancer in nude mice...

  3. A public relations identity for the 2010s

    NARCIS (Netherlands)

    Ihlen, Ø.; Verhoeven, P.

    2012-01-01

    New voices are being heard and new questions are being asked within the field of public relations. However, in its present multifaceted state, public relations research is still struggling with recurring questions regarding academic and practical contributions. This position article presents some

  4. Emotional Intelligence and Its Link to Public Relations Education

    Science.gov (United States)

    Howard, Timothy Lent

    2011-01-01

    The purpose of this study is to examine the ethics chapters in five introduction-to-public relations textbooks and the codes of ethics of four major public relations associations contained within those chapters to determine the prevalence of language that either uses the same terms Daniel Goleman employs for his 25 competencies of emotional…

  5. Elements of Public Relations Practice in the Administration of Wukari ...

    African Journals Online (AJOL)

    This study focuses on those activities of the Wukari Traditional Council in Taraba State that are similar to modern Public Relations practice. The essence is to ascertain the authenticity of the claim that Public Relations is not alien to Africa even though its practice in the contemporary times might be quite different from the ...

  6. Negotiation as a Model for Teaching Public Relations Professionalism.

    Science.gov (United States)

    Saunders, Martha Dunagin; Perrigo, Eileen

    1998-01-01

    Shows that negotiation provides an effective model for teaching public relations professionalism. Describes how two professors in a public relations class used a negotiation model to teach students to simultaneously balance the two components of professionalism: ethical considerations and pragmatic, problem-solving measures. (SR)

  7. The Genesis of Public Relations in British Colonial Practice.

    Science.gov (United States)

    Smyth, Rosaleen

    2001-01-01

    Demonstrates how the British Colonial Office employed public relations strategies as they administered the British colony of Northern Rhodesia before, during, and after World War II. Demonstrates how civil servants in London and colonial officials implemented public relations policies, strategies, and tactics on an ad hoc basis, covering political…

  8. Testing the Contingency Theory of Accommodation in Public Relations.

    Science.gov (United States)

    Cancel, Amanda E.; Mitrook, Michael A.; Cameron, Glen T.

    1999-01-01

    Interviews 18 public-relations professionals to provide grounding and refinement of the contingency theory of accommodation in public relations. Supports a continuum from pure accommodation to pure advocacy and a matrix of variables affecting the continuum. Concludes that the practitioners' view of their communication world offers validity to the…

  9. Public attitudes towards industrial, work-related and other risks

    International Nuclear Information System (INIS)

    Prescott-Clarke, P.

    1982-01-01

    Two reports describing work sponsored by the Health and Safety Executive are presented. The first describes a study of public attitudes towards industrial, work related, nuclear industry related and other risks. The second report describes public attitudes towards the acceptability of risks. (U.K.)

  10. Selective inhibition of retinal angiogenesis by targeting PI3 kinase.

    Directory of Open Access Journals (Sweden)

    Yolanda Alvarez

    Full Text Available Ocular neovascularisation is a pathological hallmark of some forms of debilitating blindness including diabetic retinopathy, age related macular degeneration and retinopathy of prematurity. Current therapies for delaying unwanted ocular angiogenesis include laser surgery or molecular inhibition of the pro-angiogenic factor VEGF. However, targeting of angiogenic pathways other than, or in combination to VEGF, may lead to more effective and safer inhibitors of intraocular angiogenesis. In a small chemical screen using zebrafish, we identify LY294002 as an effective and selective inhibitor of both developmental and ectopic hyaloid angiogenesis in the eye. LY294002, a PI3 kinase inhibitor, exerts its anti-angiogenic effect in a dose-dependent manner, without perturbing existing vessels. Significantly, LY294002 delivered by intraocular injection, significantly inhibits ocular angiogenesis without systemic side-effects and without diminishing visual function. Thus, targeting of PI3 kinase pathways has the potential to effectively and safely treat neovascularisation in eye disease.

  11. Genetic regulation of systemic angiogenesis in the mouse lung.

    Science.gov (United States)

    Mitzner, W; Srisuma, S; Wagner, E

    2003-10-01

    The work in this study takes advantage of a new experimental model in the mouse that completely isolates the angiogenic process from the direct effects of ischemia. The model also leads to lung angiogenesis that mimics the vascular source of many lung pathologies, and allows investigation of the temporal and spatial factors that can promote or inhibit angiogenesis. This work describes the expression patterns of genes relevant to pro-angiogenic signals and conditions in response to ischemia in the lung. The most notable changes were increases in the expression of genes involved in inflammation and tissue remodeling. In particular, the results confirm a important role of ELR+ CXC chemokines as proangiogenic signals. In addition, the experimental findings in this mouse lung model show that lung ischemia, rather than hypoxia, is the essential trigger for angiogenesis. Results from this model also suggest potential approaches for determining critical pathways and potential therapeutic strategies related to the control of angiogenesis.

  12. Mass Communication, Public Communication, and Interpersonal Communication: A Global Model for International Public Relations.

    Science.gov (United States)

    Neff, Bonita Dostal

    A participatory model of public relations proposed by Dean Kruckeberg and Kenneth Starck would seek not to serve a public but to build a sense of community. In this model the advocacy focus of the publicity model is dropped and there is a movement toward relationships rather than selling products and services. Leaving behind the journalistic…

  13. Role of the p38 pathway in mineral trioxide aggregate-induced cell viability and angiogenesis-related proteins of dental pulp cell in vitro.

    Science.gov (United States)

    Huang, S-C; Wu, B-C; Kao, C-T; Huang, T-H; Hung, C-J; Shie, M-Y

    2015-03-01

    To investigate the influence of mineral trioxide aggregate (MTA) on angiogenesis of primary human dental pulp cells (hDPCs) via the MAPK pathway, in particular p38. Human dental pulp cells were cultured with MTA to angiogenesis, after which cell viability, ion concentration, osmolality, NO secretion, the von Willebrand factor (vWF) and angiopoietin-1 (Ang-1) protein expression were examined. PrestoBlue(®) was used for evaluating the proliferation of hDPCs. An enzyme-linked immunosorbent assay was employed to determine vWF and Ang-1 protein secretion in hDPCs cultured on MTA and the control. Cells cultured on the tissue culture plate without the cement were used as the control. The t-test was used to evaluate the significance of the differences between the mean values. Mineral trioxide aggregate elicited a significant (P MTA consumed calcium and phosphate ions, and released more Si ions in the medium. MTA significantly (P MTA. Expression levels for Ang-1 and vWF in hDPCs on MTA were higher than those of the MTA + p38 inhibitor (SB203580) group (P Mineral trioxide aggregate was able to activate the p38 pathway in hDPCs cultured in vitro. Moreover, Si increased the osmolality required to facilitate the angiogenic differentiation of hDPCs via the p38 signalling pathway. When the p38 pathway was blocked by SB203580, the angiogenic-dependent protein secretion decreased. These findings verify that the p38 pathway plays a key role in regulating the angiogenic behaviour of hDPCs cultured on MTA. © 2014 International Endodontic Journal. Published by John Wiley & Sons Ltd.

  14. The Global Society and Its Impact on Public Relations Theorizing

    DEFF Research Database (Denmark)

    Valentini, Chiara; Kruckeberg, Dean; Starck, Kenneth

    2016-01-01

    This article contributes to the discussion on societal changes and their impact on communication disciplines by focusing on public relations and its role in contemporary global society. The thesis is that public relations profession has been affected by contemporary societal changes that challenge...... the existing body of knowledge and its underpinning theories. To understand the role of public relations in the 21st Century global societies and pursue future public relations theorizing, the authors argue it is paramount to comprehend which factors at macro, meso, and micro levels lie beneath the substantial...... changes in today’s global society. The article presents and reflects on four major macro trends of contemporary global society and concludes with suggestions for future directions for public relations scholarship and practice that are rooted in the concept of community and the idea of being part...

  15. The Global Society and Its Impact on Public Relations Theorizing

    DEFF Research Database (Denmark)

    Valentini, Chiara; Kruckeberg, Dean; Starck, Kenneth

    2016-01-01

    This article contributes to the discussion on societal changes and their impact on communication disciplines by focusing on public relations and its role in contemporary global society. The thesis is that public relations profession has been affected by contemporary societal changes that challenge...... changes in today’s global society. The article presents and reflects on four major macro trends of contemporary global society and concludes with suggestions for future directions for public relations scholarship and practice that are rooted in the concept of community and the idea of being part...... the existing body of knowledge and its underpinning theories. To understand the role of public relations in the 21st Century global societies and pursue future public relations theorizing, the authors argue it is paramount to comprehend which factors at macro, meso, and micro levels lie beneath the substantial...

  16. Research study on public relations and public participation in the nuclear energy field

    International Nuclear Information System (INIS)

    Gunji, Ikuko; Tabata, Rimiko; Otoshi, Sachio; Kuwagaki, Reiko; Ishibashi, Yoichiro

    2006-01-01

    The purpose of this research is to clarify the effect of public relations activities in the nuclear energy field and public participation toward the improvement of the risk literacy of nuclear energy. According to the survey results of the actual public relations activities taken by nuclear energy industry, the opportunity for interactive communications between the public and the industry is insufficient. Consequently, we propose building up more opportunities for participation and collaboration of citizens and industries in order to improve interactive communications reflecting public opinions and points of view. (author)

  17. Cerebral insulin, insulin signaling pathway, and brain angiogenesis.

    Science.gov (United States)

    Zeng, Yi; Zhang, Le; Hu, Zhiping

    2016-01-01

    Insulin performs unique non-metabolic functions within the brain. Broadly speaking, two major areas of these functions are those related to brain endothelial cells and the blood-brain barrier (BBB) function, and those related to behavioral effects, like cognition in disease states (Alzheimer's disease, AD) and in health. Recent studies showed that both these functions are associated with brain angiogenesis. These findings raise interesting questions such as how they are linked to each other and whether modifying brain angiogenesis by targeting certain insulin signaling pathways could be an effective strategy to treat dementia as in AD, or even to help secure healthy longevity. The two canonical downstream pathways involved in mediating the insulin signaling pathway, the phosphoinositide-3 kinase (PI3K), and mitogen-activated protein kinase (MAPK) cascades, in the brain are supposed to be similar to those in the periphery. PI3K and MAPK pathways play important roles in angiogenesis. Both are involved in stimulating hypoxia inducible factor (HIF) in angiogenesis and could be activated by the insulin signaling pathway. This suggests that PI3K and MAPK pathways might act as cross-talk between the insulin signaling pathway and the angiogenesis pathway in brain. But the cerebral insulin, insulin signaling pathway, and the detailed mechanism in the connection of insulin signaling pathway, brain angiogenesis pathway, and healthy aging or dementias are still mostly not clear and need further studies.

  18. Angiogenesis in male breast cancer

    Directory of Open Access Journals (Sweden)

    Kanthan Rani

    2005-03-01

    Full Text Available Abstract Background Male breast cancer is a rare but aggressive and devastating disease. This disease presents at a later stage and in a more advanced fashion than its female counterpart. The immunophenotype also appears to be distinct when compared to female breast cancer. Angiogenesis plays a permissive role in the development of a solid tumor and provides an avenue for nutrient exchange and waste removal. Recent scrutiny of angiogenesis in female breast cancer has shown it to be of significant prognostic value. It was hypothesized that this holds true in invasive ductal carcinoma of the male breast. In the context of male breast cancer, we investigated the relationship of survival and other clinico-pathological variables to the microvascular density of the tumor tissue. Methods Seventy-five cases of primary male breast cancer were identified using the records of the Saskatchewan Cancer Agency over a period of 26 years. Forty-seven cases of invasive ductal carcinoma of the male breast had formalin-fixed paraffin-embedded tissue blocks that were suitable for this study. All cases were reviewed. Immunohistochemical staining was performed for the angiogenic markers (cluster designations 31 (CD31, 34 (CD34 and 105 (CD105, von Willebrand factor (VWF, and vascular endothelial growth factor (VEGF. Microvascular density (MVD was determined using average, centre, and highest microvessel counts (AMC, CMC, and HMC, respectively. Statistical analyses compared differences in the distribution of survival times and times to relapse between levels of MVD, tumor size, node status and age at diagnosis. In addition, MVD values were compared within each marker, between each marker, and were also compared to clinico-pathological data. Results Advanced age and tumor size were related to shorter survival times. There were no statistically significant differences in distributions of survival times and times to relapse between levels of MVD variables. There was no

  19. The Research Base for a Public Relations Curriculum: A National Survey of Topics "Essential" to a Public Relations Curriculum.

    Science.gov (United States)

    Kendall, Robert; Anderson, James W.

    In order to rate the importance of elements involved in a public relations curriculum, a study analyzed the responses of public relations educators from all academic associations teaching the subject as well as practitioners from all specializations. Questionnaires were sent to 544 people who rated 110 elements as not essential to essential on a…

  20. The Double-Edged Sword of Legitimacy in Public Relations

    DEFF Research Database (Denmark)

    Merkelsen, Henrik

    2011-01-01

    Purpose – This paper seeks to clarify the various aspects of legitimacy in public relations in order to establish a better understanding of the limits of professionalization. Legitimacy has always been a central concept in public relations. In order to ensure a license to operate, the conduct...... of organizations needs to be perceived as legitimate by their stakeholders and the public in general. Public relations has since its conception as a modern profession been confronted with several issues concerning the profession's own legitimacy. The overall cause for these legitimacy problems is often ascribed...... to the immaturity of the profession and professionalization is generally regarded as an appropriate cure. Design/methodology/approach – Through theorization of the connection between legitimacy, power and professionalization the paper points to two important challenges to the professionalization of public relations...

  1. Reactive oxygen species and synthetic antioxidants as angiogenesis modulators: Clinical implications.

    Science.gov (United States)

    Radomska-Leśniewska, Dorota M; Hevelke, Agata; Skopiński, Piotr; Bałan, Barbara; Jóźwiak, Jarosław; Rokicki, Dariusz; Skopińska-Różewska, Ewa; Białoszewska, Agata

    2016-04-01

    Angiogenesis is important for normal functioning of organism and its disturbances are observed in many diseases, called angiogenesis-related states. Reactive oxygen species (ROSs) play an important role in physiology, but high level of cellular ROSs is cytotoxic and mutagenic for the cells, i.e. it can lead to oxidative stress. In this review we discuss close relationship between ROSs and angiogenesis process. Substances counteracting free radicals or their action and oxidative stress are known as antioxidants. We postulate that antioxidants, by affecting angiogenesis, may modulate therapy results in the case of angiogenesis-related disease. Herein, we present some antioxidant preparations of synthetic (N-acetylcysteine, curcumin and its analogs, Probucol, oleane tripertenoid, EGCG synthetic analogs) and nature-identical (vitamin E and C) origin. Then, we analyze their angiogenic properties and their multidirectional molecular effect on angiogenesis. Most preparations reduce neovascularization and diminish the level of proangiogenic molecules, downregulating signaling pathways related to angiogenesis. Moreover, we discuss studies concerning anticancer properties of presented synthetic antioxidants and their application in several angiogenesis-related diseases. We conclude that therapy in angiogenesis-related diseases should be planned with consideration of the angiogenic status of the patient. Copyright © 2015 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.

  2. The Role of CC-Chemokines in the Regulation of Angiogenesis

    Directory of Open Access Journals (Sweden)

    Anisyah Ridiandries

    2016-11-01

    Full Text Available Angiogenesis, the formation of new blood vessels, is critical for survival and in the regenerative response to tissue injury or ischemia. However, in diseases such as cancer and atherosclerosis, inflammation can cause unregulated angiogenesis leading to excessive neovascularization, which exacerbates disease. Current anti-angiogenic therapies cause complete inhibition of both inflammatory and ischemia driven angiogenesis causing a range of side effects in patients. Specific inhibition of inflammation-driven angiogenesis would therefore be immensely valuable. Increasing evidence suggests that the CC-chemokine class promotes inflammation-driven angiogenesis, whilst there is little evidence for a role in ischemia-mediated angiogenesis. The differential regulation of angiogenesis by CC-chemokines suggests it may provide an alternate strategy to treat angiogenesis associated pathological diseases. The focus of this review is to highlight the significant role of the CC-chemokine class in inflammation, versus ischemia driven angiogenesis, and to discuss the related pathologies including atherosclerosis, cancer, and rheumatoid arthritis. We examine the pros and cons of anti-angiogenic therapies currently in clinical trials. We also reveal novel therapeutic strategies that cause broad-spectrum inhibition of the CC-chemokine class that may have future potential for the specific inhibition of inflammatory angiogenesis.

  3. Melatonin as an angiogenesis inhibitor to combat cancer: Mechanistic evidence.

    Science.gov (United States)

    Goradel, Nasser Hashemi; Asghari, Mohammad Hossein; Moloudizargari, Milad; Negahdari, Babak; Haghi-Aminjan, Hamed; Abdollahi, Mohammad

    2017-11-15

    Melatonin, a pineal indolamine, participates in different body functions and is shown to possess diverse biological activities such as anti-tumor action. Angiogenesis inhibition is one of the mechanisms by which melatonin exerts its oncostatic effects. Increased angiogenesis is a major feature of tumor progression, thus angiogenesis inhibition is a critical step in cancer therapy. Melatonin employs a variety of mechanisms to target nutrients and oxygen supply to cancer cells. At the transcriptional level, hypoxia induced factor-1α (HIF-1α) and the genes under its control, such as vascular endothelial growth factor (VEGF) are the main targets of melatonin for inhibition of angiogenesis. Melatonin prevents translocation of HIF-1α into the nucleus thereby hindering VEGF expression and also prevents the formation of HIF-1α, phospho-STAT3 and CBP/p300 complex which is involved in the expression of angiogenesis-related genes. Angiostatic properties of melatonin could be also due to its ability to inhibit VEGFR2's activation and expression. Other angiostatic mechanisms of melatonin include the inhibition of endothelial cell migration, invasion, and tube formation. In the present study, we have reviewed the molecular anti-angiogenesis pathways mediated by melatonin and the responsible mechanisms in various types of cancers both in vitro and in vivo. Copyright © 2017 Elsevier Inc. All rights reserved.

  4. Global health-related publications in otolaryngology are increasing.

    Science.gov (United States)

    Chambers, Kyle J; Creighton, Francis; Abdul-Aziz, Dunia; Cheney, Mack; Randolph, Gregory W

    2015-04-01

    Determine trends in global health-related publication in otolaryngology. A review of research databases. A search of publications available on PubMed and nine additional databases was undertaken reviewing two time periods 10 years apart for the timeframes 1998 to 2002 (early time period) and 2008 to 2012 (recent time period) using specific search terms to identify global health-related publications in otolaryngology. Publications were examined for region of origin, subspecialty, type of publication, and evidence of international collaboration. χ and t test analyses were used to identify trends. In the 1998 to 2002 time period, a total of 26 publications met inclusion criteria for the study, with a mean of 5.2 ± 2.8 publications per year. In the 2008 to 2012 time period, a total of 61 publications met inclusion criteria, with a mean of 12.3 ± 5.6 publications per year. The 235% increase in global health-related publications identified between the two study periods was statistically significant (P = .02). The absolute number of publications in which collaboration occurred between countries increased from three in the early time period to nine the recent time period. There has been a significant increase in the volume of global health-related publications in English language otolaryngology journals over the past decade, providing strong evidence of the increasing trend of global health as an academic pursuit within the field of otolaryngology. © 2014 The American Laryngological, Rhinological and Otological Society, Inc.

  5. Molecular Therapeutic Targets for Glioma Angiogenesis

    Directory of Open Access Journals (Sweden)

    Shingo Takano

    2010-01-01

    Full Text Available Due to the prominent angiogenesis that occurs in malignant glioma, antiangiogenic therapy has been attempted. There have been several molecular targets that are specific to malignant gliomas, as well as more broadly in systemic cancers. In this review, I will focus on some topics related to molecular therapeutic targets for glioma angiogenesis. First, important angiogenic factors that could be considered molecular targets are VEGF, VEGF-induced proteins on endothelial cells, tissue factor, osteopontin, v3 integrin, and thymidine phosphorylase as well as endogenous inhibitors, soluble Flt1, and thrombospondin 1. Second, hypoxic areas are also decreased by metronomic CPT11 treatment as well as temozolomide. Third, glioma-derived endothelial cells that are genetically and functionally distinct from normal endothelial cells should be targeted, for example, with SDF-1 and CXCR7 chemokine. Fourth, endothelial progenitor cells (EPCs likely contribute towards glioma angiogenesis in the brain and could be useful as a drug delivery tool. Finally, blockade of delta-like 4 (Dll4 results in a nonfunctioning vasculature and could be another important target distinct from VEGF.

  6. Trends in gas marketing: the role of public relations

    Energy Technology Data Exchange (ETDEWEB)

    Vinegrad, A.

    1978-01-01

    By effectively communicating company policies and relevant information concerning the energy situation both to the general public and to employees, public-relations efforts can make a substantial contribution to the success of marketing gas supplies in the future, according to the British Gas Corp. The public's perception of such issues as the availability of gas, assuredness of supply, cost relative to competing sources of energy, environmental impact of gas-industry operations, security of the consumer's investment in major appliances, fairness of pricing policies, quality of the gas product, and efficiency of service will significantly influence the industry's ability to retain a rasonable share of the energy market. To maintain credibility with the public, gas-industry public-relations personnel will have to explain the dimensions and complexity of industry operations while meeting the consumer's expectations for increasing levels of service.

  7. Promoting a Positive Image: Public Relations Strategies for Special Educators.

    Science.gov (United States)

    Brennan, Kathleen B.; Miller, April D.; Brennan, J. Patrick, II

    2000-01-01

    A positive public relations campaign specific to special education can stimulate teacher cooperation and principal support, improve community perceptions of special education students, and increase hiring of special education students by local businesses. A monthly calendar of suggested activities and guidelines for starting a public relations…

  8. Peran the Public Relation Mix Dalam Membangun Komunikasi Yang Efektif

    OpenAIRE

    Nurhayati, Afita

    2012-01-01

    In communication tools, the public relation mix takesimportant role in order to develop an effective communication. The role is done by developing credibility so it will increase the visibility of company or organization, and finally the positive image of the product still keep on, both goods and services in the public sight.

  9. GENDER BIAS IN THE PUBLIC RELATIONS INDUSTRY IN MALAYSIA: COMPARING PUBLIC RELATIONS PRACTITIONERS’ JOB FUNCTIONS, INCOMES, AND CAREER PROSPECTS

    Directory of Open Access Journals (Sweden)

    Yesuselvi Manickam

    2016-12-01

    Full Text Available Today, there is an increase in women working outside their home to sustain themselves economically and socially, but the working experiences can be problematic for women when gender discrimination exists in the workplace. In the early 1960s, women were entering the public relations industry at a rate faster than their male counterparts, but gender bias was a sore issue in the industry. Numerous studies have been conducted on gender bias, and the findings indicate that female public relations practitioners receive unequal treatment in their organisation. For that reason, this study investigated whether gender bias exists in the public relations industry in Klang Valley, Malaysia, and if so, what the impact was on the practitioners’ work performance. The study used an in-depth interview with five public relations practitioners from public relations agencies and corporate companies. Feminist Standpoint Theory served as a framework for this study. Results revealed that in Malaysia, gender bias is not prevalent because of cultural diversity and company policies. The priorities of these public relations agencies and organisations favor employee’s performance and competence over gender. The results also indicated that public relations practitioners are treated fairly in areas of career prospects, job functions, and remuneration.

  10. Public Relations Education at the Crossroad: Trend and Realities.

    Directory of Open Access Journals (Sweden)

    Jamilah Hj. Ahmad FIPR, PhD.

    2013-12-01

    Full Text Available Abstract: This paper explores the issues of public relations academics credentials on teaching public relations at undergraduate level. Generally, most Asian universities look to the United States education system as the ideal model in developing their own curricula, and frequently invite American professors as visiting fellows to help set up their programmes. In addition, Asian universities, including those in Malaysia and Indonesia still harbour the view that the US offers the best public relations education and practices, and therefore follow the US model regarding any matters related to curriculum, study materials, teaching modules, learning resources and the structure of exam papers. Whilst seeming efficient, as the US leads the fields of public relations, it appears to be done blindly without considering such variables as the encompassing political, economic, legal, media and cultural factors of the society adapting these curricula that should determine the roles and functions of public relations practitioners in any given country. This paper concludes that US still offers the best public relations education in comparison to any Asian universities due to lack of academic credentials.

  11. What a public-relations-model regarding radioactive waste implicates

    Energy Technology Data Exchange (ETDEWEB)

    Ohnishi, Teruaki [CRC Research Institute, Inc., Tokyo (Japan)]|[Energy Research Center Wakasa Bay, Fukui (Japan)

    1996-12-31

    The behavior of public attitude to radioactive waste with time was investigated by using a mathematical model which was developed for estimating the extent of attitude change, being based on the assumption that the change of public attitude to a certain subject is caused by the information environment mainly formed by the newsmedia. Investigations were also made on the extent the public relations activity can contribute to the change of public opinion for the radioactive waste, and on the method of assortment and execution of various types of activity which brings the maximum change of attitude under a given condition of budget.

  12. Selecting public relations personnel of hospitals by analytic network process.

    Science.gov (United States)

    Liao, Sen-Kuei; Chang, Kuei-Lun

    2009-01-01

    This study describes the use of analytic network process (ANP) in the Taiwanese hospital public relations personnel selection process. Starting with interviewing 48 practitioners and executives in north Taiwan, we collected selection criteria. Then, we retained the 12 critical criteria that were mentioned above 40 times by theses respondents, including: interpersonal skill, experience, negotiation, language, ability to follow orders, cognitive ability, adaptation to environment, adaptation to company, emotion, loyalty, attitude, and Response. Finally, we discussed with the 20 executives to take these important criteria into three perspectives to structure the hierarchy for hospital public relations personnel selection. After discussing with practitioners and executives, we find that selecting criteria are interrelated. The ANP, which incorporates interdependence relationships, is a new approach for multi-criteria decision-making. Thus, we apply ANP to select the most optimal public relations personnel of hospitals. An empirical study of public relations personnel selection problems in Taiwan hospitals is conducted to illustrate how the selection procedure works.

  13. News of Rhodesia: The Impact of a Public Relations Campaign.

    Science.gov (United States)

    Albritton, Robert B.; Manheim, Jarol B.

    1983-01-01

    Concludes that after Rhodesia hired a public relations firm to advise it, negative comment about that country declined sharply in the "New York Times," although news of violence there remained virtually the same. (FL)

  14. UNIPEDE: session of the public relations study committee

    International Nuclear Information System (INIS)

    Peter, A.

    1987-01-01

    The author gives a brief resume of the 8th public relations conference entitled 'Foerderung des Image der Elektrizitaetswirtschaft' (Improving the image of the electric power industry). The discussions were mainly centred on nuclear energy

  15. Back to the Future: International Education in Public Relations.

    Science.gov (United States)

    Sommerness, Martin D.; Beaman, Ronda

    1994-01-01

    Finds few offerings of university courses emphasizing international public relations across the United States, despite global trends underlining increased internationalization. Argues that individuals and organizations must take account of those trends to stay abreast of the changing environment. (SR)

  16. Understanding News Values: Secret to Good Public Relations.

    Science.gov (United States)

    Oates, Rita Haugh

    1981-01-01

    Explains the news values that journalists use. Shows English teachers and administrators how they can apply this knowledge of news media to improve public relations between the school and the community. (RL)

  17. Internet: A New Tool for Mass Communication and Public Relations

    Directory of Open Access Journals (Sweden)

    Erol Yılmaz

    1996-09-01

    Full Text Available The importance of the Internet as a tool for mass communication and public relations is emphasized and the use of Internet for such purposes in librarianship and infor­mation studies is explained.

  18. Evidence on the relation between public capital and Government efficiency

    OpenAIRE

    Francisca Guedes de Oliveira

    2010-01-01

    This paper intends to contribute to the literature by providing empirical evidence on the relation between public capital stock and government efficiency. We present some objective indicators fo government efficiency and explore the mentioned relation. we find a positive and significant relation between both variables that survives the introduction of controls and robustness checking.

  19. Pemanfaatan Social Media oleh Praktisi Public Relations di Yogyakarta

    OpenAIRE

    Pienrasmi, Hanindyalaila

    2017-01-01

    Social media has changes the way public relations practitioners in doing their jobs related to communicate with the public how to communicate both individually and at the corporate level. Social media become a challenge for practitioners to improve their technical and managerial abilities as a professional to deak with the development of new technology. Practitioners continue to know more about social media in order to optimize utilization and help the company to establish a better relationsh...

  20. Strategi Cyber Public Relations dalam Pembentukan Citra Institusi Pendidikan Tinggi Swasta

    OpenAIRE

    Gita Aprinta E. B.

    2016-01-01

    As a strategy public relations, cyber public relations gives the new meaning for public relations practioners, especially in buliding positive image of private university (PTS). Trough cyber public relations, communcation between PTS and it public, can be bridge quickly and easy. Moreover, cyber public relations strategy provides dynamic and personal interaction, so that public posses their personal intepretation about the PTS.

  1. To what extent can the nuclear public relations be effective?

    Energy Technology Data Exchange (ETDEWEB)

    Ohnishi, Teruaki [CRC Research Institute, Tokyo (Japan)

    1996-06-01

    The effect of public relations (PRs) on the public`s attitude to nuclear energy was assessed using a model developed under the assumption that the extent of attitude change of the public by the PRs activity is essentially the same as that by the nuclear information released by the newsmedia. The attitude change of the public was quantitatively estimated by setting variables explicitly manifesting the activities such as the circulation of exclusive publicity and the area of advertising messages in the newspaper as parameters. The public`s attitude became clear to have a nonlinear dependence on the amount of activity, the extent of its change being varied considerably with demographic classes. Under a given financial condition, the offer of PRs information to the people, as many as possible in a target region, in spite of its little force of appeal, was found to be more effective for the amelioration of public attitude than the repeated offer of the information to a limited member of the public. It also became clear that there exists the most effective media mix for the activity depending on the extent of target region and on the target class of demography, therefore, it is quite significant to determine beforehand the proper conditions for the activity to be executed, such a situation indicating the need for the introduction of nuclear PRs management. (Author).

  2. Upaya Pemulihan Citra Perum Perhutani: Studi Manajemen Public Relations

    Directory of Open Access Journals (Sweden)

    Tresna Wiwitan

    2005-06-01

    Full Text Available Regarding the significant decrease of Indonesia woodland, the management of wood resources becomes the main issue these days. The lack of professionalism attending this matter give bad publicity to Perum Perhutani who responsible to maintain wood resources. It is believed that Public Relations (PR practices played a key role to improve the negative image of Perum Perhutani. Using PR planning steps such as defining PR problems, collecting data toward public opinions, finding key informants, and implementing community relation activities, the problems were solved successfully.

  3. Leaving Public Schools for Home Schooling: Implications for School Public Relations.

    Science.gov (United States)

    McLeod, Suzanne E.; Osterman, Karen F.

    2003-01-01

    Addresses the sources of dissatisfaction from parents who had removed their children from public schools to begin home schooling. Implications for public schools' community relations and practice specifically focus on three areas of greatest concern: student grouping practices, peer relationships, and the extension of the school day via homework.…

  4. A STUDY OF SYMBOLIC RELATIONS IN PUBLIC TRANSPORT

    Directory of Open Access Journals (Sweden)

    ANDREI BALAN

    2011-04-01

    Full Text Available This paper presents an anthropological, exploratory study of the microsocial world of public transport. Our research focuses on the symbolic relations that are being established (verbally or nonverbally between urban transport travellers that do not know each other and the consequences these relations create. Modern urban configuration forces large numbers of individuals to share public space every day. When this space becomes restrictive, symbolic relations and interpersonal behaviors such as territoriality and personal space management become clearer. Due to overcrowding, public transport is the scene of one of the most restrictive public spaces in a city. The challenge was to observe and interpret daily, casual behaviors through a sociological and psychological scheme, following the methodological tradition established by Erving Goffman and the other symbolic interactionists. Finally, our study generates a number of hypotheses and explanatory models for common practices and behaviors in trams and metros regarded from a symbolic perspective.

  5. Corporate Social Capital and Public Relations : Capital Accumulation by Social Relationship and Rethinking the Definition of Public Relations

    OpenAIRE

    北見, 幸一

    2009-01-01

    This paper discusses Corporate Social Capital and Public Relations. This paper overviewed the Social Capital studies, especially early studies in sociology field, proposed the framework to evaluate Social Capital in a capital. Social Capital has the merit to reduce transaction costs, and should be clearly positioned as a component of capital of corporation. Using the concept of the Corporate Social Capital, to rethink the definition of Public Relations, this paper proposed the following defin...

  6. Institutions of Civil Society Participating in Public Relations

    Directory of Open Access Journals (Sweden)

    Olga S. Belokrylova

    2016-12-01

    Full Text Available The degree of maturity of the civil society of a country is now seen as an important indicator of the development of a socially oriented market economy. The authors explore two forms of state and civil society relations - qualitative, characterized by the diffusion of a relationship of trust in society, and quantitative, in the system of public procurement corruption identifiable pace of localization. Institutional capacity development of civil society in public relations is the simultaneous modernization of the qualitative and quantitative scope of its relationship with the state. The paper presents the mechanism of transition to a partnership model relations between the state and civil society, the most important form of which is the realization of public control, rapid formal institutionalization which has provided detection and elimination of large-scale irregularities in public procurement. Its swift formal institutionalization provided by representatives of civil society to identify and eliminate large-scale irregularities in public procurement. The experience of NGO Fund "Sodeistvie - XXI vek" to identify "blind" purchases, is offered as a tool to improve the efficiency of public control conduct free training of potential public controlles by institutions engaged in training of civil officials for the course "Management of state and municipal procurement".

  7. Private public diplomacy. The end of public hegemony over international relations

    Directory of Open Access Journals (Sweden)

    Luis Melgar

    2014-09-01

    We could be witnessing a completely new model: a private public diplomacy that would be based on a sovereign states definitive withdrawal from their monopoly on international relations in favour of the private sector.

  8. Clinicopathologic study of angiogenesis in Japanese patients with breast cancer.

    Science.gov (United States)

    Kato, T; Kimura, T; Miyakawa, R; Tanaka, S; Fujii, A; Yamamoto, K; Kameoka, S; Hamano, K; Kawakami, M; Aiba, M

    1997-01-01

    To evaluate the clinicopathologic significance of angiogenesis as a prognostic factor and the objective methods for evaluating angiogenesis, we immunohistochemically stained a representative section of breast tumors with factor VIII-related antigen staining. There were 109 patients with primary breast cancer from 1971 to 1979. The two methods of identifying angiogenesis were the average microvessel count per square millimeter (AMC) and the highest microvessel count per square millimeter (HMC). There was no relation between microvessel count (AMC or HMC) or age, menopausal status, clinical tumor size (T), histologic classification, nuclear grade, node status, histologic grade (HG), mitosis index, or lymphatic invasion (LI). There was a relation between microvessel count and blood vessel invasion (BVI) (HMC:p = 0.0007) and tumor necrosis (TN) (HMC:p = 0.0050). Univariate analysis showed that AMC or HMC was a statistically significant predictor of overall survival in all patients (p = 0.0086 and p = 0.0307, respectively). Multivariate analysis showed that AMC was an independent predictor of node status when we fitted a model with node status, BVI, and either AMC or HMC; but HMC was not independent. However, when we fitted a model including all 11 of the other indicators and AMC or HMC, the node status, HG, and LI were independent predictors, but AMC and HMC were not. Although AMC was a better method than HMC for evaluating angiogenesis, we cannot confirm angiogenesis as a significant independent prognostic factor associated with long-term survival in Japanese breast cancer patients.

  9. Strategi Public Relations dalam Mendukung Pemasaran Pembangkit Listrik Nasional (PLN

    Directory of Open Access Journals (Sweden)

    Novi Anggraeni

    2014-07-01

    Full Text Available Public relations is one of the elements that determine the viability of an organization positively. The purpose of the research; 1. Knowing the planning public relations strategies in support of marketing; 2. Knowing the kinds of public relations activities; 3. Knowing the packaging contents of the message of the communication media used; 4. Knowing the effect to be achieved; and 5. Knowing the obstacles faced. The method used descriptive qualitative. Results of the study are: 1. Judging from the background criteria for Public Relations of PT. PLN (Persero APJ Cirebon is formal education, job experience, appearance, skills, individual characteristics, and adaptation, credible communicator. 2. Kegiatan Public Relations to support the marketing of which the existence of a local radio talk show in Cirebon (Cirebon FM, a local television talk show in Cirebon (RCTV, cooperation in carrying out tasks related to corporate law. 3. Packaging persuasive message content, preparation of informative messages are intended to provide excitement and build consumer understanding. 4. The effect achieved a change in opinions, attitudes and behavior. 5. Barriers found limited use of communication media and the lack of communication superiors and subordinates

  10. Public Relations and CSR as a Part of Corporate Legitimation

    Directory of Open Access Journals (Sweden)

    Irene Buhăniță

    2015-10-01

    Full Text Available This article provides a review of public relations literature in relation with CSR, through an analysis of academic research done in 1999-2014 period and published in three main scientific journals. The content of this literature shows that researchers looked for new perspectives along the years, broadening Clark’s approach (2000 of communication management to encompass management function and relationship management as well. The findings of the study suggest that the accent on processes may address ethics or legitimation topics in public relation as well as in CSR, because of the improved relationships they can establish between organizations, stakeholders and society.

  11. EMPLOYER-EMPLOYEE RELATIONS IN THE PUBLIC SCHOOLS.

    Science.gov (United States)

    DOHERTY, ROBERT E.

    THIS VOLUME CONTAINS PAPERS PRESENTED AT THE CONFERENCE ON EMPLOYEE RELATIONS IN THE PUBLIC SCHOOLS, HELD JULY 14-15, 1966, AT CORNELL UNIVERSITY UNDER THE AUSPICES OF THE NEW YORK STATE SCHOOL OF INDUSTRIAL AND LABOR RELATIONS AND THE NEW YORK STATE EDUCATION DEPARTMENT. THE PURPOSE OF THE CONFERENCE WAS THREEFOLD--(1) TO PROVIDE A FORUM WHERE…

  12. Gender, community affairs and public relations practice in Ghanaian ...

    African Journals Online (AJOL)

    Community affairs and public relations practice in Ghanaian mines has been dominated by females. To gain adequate understanding of this phenomenon, it is prudent to explore its gendered nature. Literature from feminist theorists draws collective attention to the centrality of gender in shaping social relations, pointing out ...

  13. Teaching Culture: The Challenges and Opportunities of International Public Relations.

    Science.gov (United States)

    George, Amiso M.

    2003-01-01

    Focuses on the challenges and opportunities for international public relations practice. Looks at current United States-Arab relations issues in international crisis communication. Discusses those issues, especially the role of culture and media. Proposes strategies including a case study that teachers can use to help students become effective…

  14. Forholdet mellem public relations og marketing som ledelsesfunktioner

    Directory of Open Access Journals (Sweden)

    James E. Grunig

    1993-09-01

    Full Text Available I forsommeren 1993 tildelte Dansk Public Relations Forening årets PR- pris til mesterkommunikatøren Lars Larsen, Jysk Sengetøjslager/Larsen Rejser. I motiveringen hedder det, at Lars Larsen hædres for "en prisvær- dig Public Relations indsats, der kan motivere til en øget anvendelse af Public Relations i den danske forretningsverden". Blandt PR-foreningens medlemmer vakte pristildelingen en vis furore; et indlæg i foreningens blad PRspektiv invendte, at Lars Larsen driver "publicity" (dvs. et reklame- værktøj - "Præcis den slags PR, som vi i mange år har arbejdet på at distancere Public Relation-begrebet fra". Lars Larsen selv sagde, at han slet ikke skelner mellem Public Relations, PR og markedsføring. Et andet indlæg i bladet argumenterede for, at det ikke længere giver mening at adskille begreberne Public Relations og markedsføring, fordi grænsen mellem det offentlige og det private ude i virkeligheden er mere og mere flydende. James Grunigs artikel, der søger at afklare forholdet mellem PR og marketing teoretisk og praktisk, er derfor brændende aktuelt, ikke mindst for PR-fagets bestræbelser på at blive anerkendt som en respek- tabel profession. Den blev præsenteret som foredrag under Grunigs Dan- marksbesøg i marts 1993, er redigeret af Kim Schrøder og oversat fra engelsk af Kenja Henriksen.

  15. Green tea and its anti-angiogenesis effects.

    Science.gov (United States)

    Rashidi, Bahman; Malekzadeh, Mehrnoush; Goodarzi, Mohammad; Masoudifar, Aria; Mirzaei, Hamed

    2017-05-01

    The development of new blood vessels from a pre-existing vasculature (also known as angiogenesis) is required for many physiological processes including embryogenesis and post-natal growth. However, pathological angiogenesis is also a hallmark of cancer and many ischaemic and inflammatory diseases. The pro-angiogenic members of the VEGF family (vascular endothelial growth factor family), VEGF-A, VEGF-B, VEGF-C, VEGF-D and placental growth factor (PlGF), and the related receptors, VEGFR-1, VEGFR-2 and VEGFR-3 have a central and decisive role in angiogenesis. Indeed, they are the targets for anti-angiogenic drugs currently approved. Green tea (from the Camellia sinensis plant) is one of the most popular beverages in the world. It is able to inhibit angiogenesis by different mechanisms such as microRNAs (miRNAs). Green tea and its polyphenolic substances (like catechins) show chemo-preventive and chemotherapeutic features in various types of cancer and experimental models for human cancers. The tea catechins, including (-)-epigallocatechin-3-gallate (EGCG), have multiple effects on the cellular proteome and signalome. Note that the polyphenolic compounds from green tea are able to change the miRNA expression profile associated with angiogenesis in various cancer types. This review focuses on the ability of the green tea constituents to suppress angiogenesis signaling and it summarizes the mechanisms by which EGCG might inhibit the VEGF family. We also highlighted the miRNAs affected by green tea which are involved in anti-angiogenesis. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  16. Crisis of confidence: utilities, public relations, and credibility

    Energy Technology Data Exchange (ETDEWEB)

    Sullivan, F.C.

    1977-01-01

    This book deals principally with the role of the public utility in the business sector and specifically with its patterns of communications in this turbulent era of changing public opinion. Offering the premise that time has almost run out to achieve public understanding in today's mounting energy crisis, Frank C. Sullivan diagnoses the problems, examines available communication techniques, and offers a pragmatic approach to action which will stimulate and challenge neophyte and professional alike. The book touches on the history of public relations, discusses its functions and role in utility management, and provides practical suggestions and sound advice on corporate credibility and accounting. Following a ''Rationale for Action'' the book's twenty-two chapters are grouped in four major sections: Public Relations and the Utility; Planning for Rate Increases; The Utility and its Publics, and Private vs. Public Ownership. In his epilogue, ''The Dimensions of Disbelief,'' the author sets forth his candid and provocative thesis for action and change.

  17. New image of psychiatry, mass media impact and public relations.

    Science.gov (United States)

    Jakovljević, Miro; Tomić, Zoran; Maslov, Boris; Skoko, Iko

    2010-06-01

    The mass media has a powerful impact on public attitudes about mental health and psychiatry. The question of identity of psychiatry as a medical profession as well as of the future of psychiatry has been the subject of much controversial discussion. Psychiatry today has the historical opportunity to shape the future of mental health care, medicine and society. It has gained in scientific and professional status by the tremendous increase of knowledge and treatment skills. Psychiatry should build up new transdisciplinary and integrative image of a specialized profession, promote it and make it public. Good public relations are very important for the future of psychiatry.

  18. To what extent can the nuclear public relations be effective?

    International Nuclear Information System (INIS)

    Ohnishi, Teruaki

    1996-01-01

    The effect of public relations (PRs) on the public's attitude to nuclear energy was assessed using a model developed under the assumption that the extent of attitude change of the public by the PRs activity is essentially the same as that by the nuclear information released by the newsmedia. The attitude change of the public was quantitatively estimated by setting variables explicitly manifesting the activities such as the circulation of exclusive publicity and the area of advertising messages in the newspaper as parameters. The public's attitude became clear to have a nonlinear dependence on the amount of activity, the extent of its change being varied considerably with demographic classes. Under a given financial condition, the offer of PRs information to the people, as many as possible in a target region, in spite of its little force of appeal, was found to be more effective for the amelioration of public attitude than the repeated offer of the information to a limited member of the public. It also became clear that there exists the most effective media mix for the activity depending on the extent of target region and on the target class of demography, therefore, it is quite significant to determine beforehand the proper conditions for the activity to be executed, such a situation indicating the need for the introduction of nuclear PRs management. (Author)

  19. Re-visioning public health ethics: a relational perspective.

    Science.gov (United States)

    Kenny, Nuala P; Sherwin, Susan B; Baylis, Françoise E

    2010-01-01

    Canada is in the forefront of thinking about the unique and complex issues of contemporary public health ethics. However, an inordinate focus on the urgent issues of emergency preparedness in pandemic and reliance on bioethical analysis steeped in the autonomy and individual rights tradition of health care and research do not serve adequately as the basis for an ethic of public health with its focus on populations, communities and the common good. This paper describes some concerns regarding the focus on pandemic ethics in isolation from public health ethics; identifies inadequacies in the dominant individualistic ethics framework; and summarizes nascent work on the concepts of relational autonomy, relational social justice and relational solidarity that can inform a re-visioning of public health ethics. While there is still much work to be done to further refine these principles, they can help to reclaim and centre the common and collective good at risk in pandemic and other emergency situations. Minimally, these principles require a policy-making process that is truly transparent, fair and inclusive; is sensitive and responsive to the workings of systemic inequalities; and requires public recognition of the fact that we enter any crisis with varying degrees of inequity. Public policy response to crisis must not forseeably increase existing inequities.

  20. Mechanisms of angiogenesis in neoplasia

    Directory of Open Access Journals (Sweden)

    Anna Antonina Sobocińska

    2016-12-01

    Full Text Available Mechanism of forming new capillary from basal vessels, named angiogenesis, exist under both physiological and pathological conditions. Initiation of this process requires imbalance between proangiogenic and antiangiogenic factors, which can occur for instance under hypoxic conditions. Angiogenesis is complex process which allow tumor cells to proliferate, thus providing tumor to increase its structure. This dependence is highly connected to enhanced migration of tumor cells through blood, which often ends up being an onset of metastasis. It has been proved that capillaries that form during tumor lifetime are different in case of morphology. However, it seems that antigens spread through these blood vessel are the same as antigens produced during physiological angiogenesis. In recent years angiogenesis has become one of the most important targets in therapies used in oncology. Antiangiogenic therapies have proven itself to be very spectacular and promising in treatment of renal and pancreatic cancers or multiple myeloma. Bewacizumab, Sunitinib, Cetuximab and Talidomid are examples of drugs used in such therapies. Tyrosine kinase inhibitors are group that represents most of the drugs of antiangiogenic properties. It is worth mentioning that during administration of such substances spectrum of side effects is observed. However, antiangiogenic therapy is one of the most promising targets in today’s oncology. Therefore, it is highly explainable to continue further research in this area.

  1. Are tumours angiogenesis-dependent?

    NARCIS (Netherlands)

    Verheul, H. M. W.; Voest, E. E.; Schlingemann, R. O.

    2004-01-01

    The final proof of principle that cancer patients can be effectively treated with angiogenesis inhibitors is eagerly awaited. Various preclinical in vivo experiments have proven that most tumours need new vessel formation in order to grow and to form metastases. First of all, tumours do not grow in

  2. Peer relations, adolescent behavior, and public health research and practice.

    Science.gov (United States)

    Crosnoe, Robert; McNeely, Clea

    2008-01-01

    Peer relations are central to adolescent life and, therefore, are crucial to understanding adolescents' engagement in various behaviors. In recent years, public health research has increasingly devoted attention to the implications of peer relations for the kinds of adolescent behaviors that have a direct impact on health. This article advocates for a continuation of this trend. With this aim, we highlight key themes in the rich literature on the general developmental significance of adolescent-peer relations, provide an overview of how these themes have been incorporated into public health research and practice, and suggest future avenues for peer-focused public health research that can inform adolescent health promotion in the United States.

  3. Konstruksi Prinsip Kinerja Public Relations Dalam Pandangan Syariat Islam

    Directory of Open Access Journals (Sweden)

    Mubarok Mubarok

    2016-07-01

    Full Text Available PR performance principle formulated as part of the management functions to achieve the objectives of an organization. Likewise with the influence of religious scriptures embraced by every individual involved in the communication process. One scripture that the reference human life is the Qur'an as a way of life of Muslims. Related to the practice and science of public relations it is interesting to look at dikontruksi how Islamic law principle of PR performance. The scales of the Shari'a as an integral part of the life of a Muslim will guide how he practice the principles of PR performance. Institutions are trying to get support through activities that can provoke support from the public without coercion or through a stage of conflict. Arthur W. Page mentions a number of principles that can be used in practice and as a philosophical PR in maintaining relations with the public institutions.

  4. Phases of the cutaneous angiogenesis process in experimental third-degree skin burns: histological and immunohistochemical study.

    Science.gov (United States)

    Busuioc, Cristina Jana; Mogoşanu, G D; Popescu, Florina Carmen; Lascăr, I; Pârvănescu, H; Mogoantă, L

    2013-01-01

    Skin burns represent a major problem of public health because of their frequency and because of their seriousness, too. The healing process of the burnt wound is extremely complex, as it requires a well-coordinated collaboration among different tissues and cellular strings. From the morphological point of view, the stages of the repairing process of the skin wounds include processes of inflammation, proliferation and tissular remodeling. Angiogenesis has a role of extreme importance within the healing process of third-degree skin burns. That is because the vascularization remake is necessary for feeding the tissue of granulation with nutritive substances and oxygen. The angiogenesis started relatively fast. Three days after the producing of the burn, there could be identified strings of CD34+ endothelial precursor cells at the edges and deep into the wound, all these having contact with the normal blood vessels or with those lees affected by the thermal aggression. After the lumenization of the newly-formed capillary vessels, there appeared the pericytes within their membrane. The CD34+ endothelial precursor cells (EPc), as well as the pericytes, participate at the synthesis of the base membrane of the angiogenesis vessels. The density of the angiogenesis vessels on the surface unit within the tissue of granulation grew from three to 12 days. After that, they reduced progressively while the tissue of granulation was becoming mature. The angiogenesis vessels go through a process of reshuffling and maturation at the same time with the maturation of the tissue of granulation, but these processes did not appear to be finished when the skin was completely healed, and the epidermis was totally recovered.

  5. Branding your medical practice with effective public relations.

    Science.gov (United States)

    Trent, Nancy

    2009-01-01

    Whether you think of it as your image, your standing in the community, or your reputation, your medical practice is also a brand. While many organizations, companies, products, and services are known for specific attributes that make them stand out from competitors, most use a combination of marketing disciplines to communicate who and what they are to their customers, consumers, and patients. Public relations is often considered the most powerful, cost-effective, and efficacious of the marketing disciplines, surpassing advertising, promotion, and direct mail in molding and developing brands. Your practice can benefit from a well-crafted branding public relations program.

  6. The Ambivalent Relations between Bureaucracy and Public Innovation:

    DEFF Research Database (Denmark)

    Schultz Larsen, Troels

    2015-01-01

    of the successful implementation but failed diffusion of an innovation project. The case study demonstrates how a bureaucratic context represents not only barriers to innovation but also a number of complex drivers. The outline of these ambivalent relations is used to tease out the Janus face of the new spirit......Building on a growing body of literature on public innovation and the rediscovery of bureaucracy, this article explores the relations between innovation and bureaucracy. A framework for studying innovation in a bureaucratic context is developed and its relevance assessed through a case study...... of innovation in public administration....

  7. Strategi Public Relations Hotel dalam Membentuk Citra Objek Wisata

    Directory of Open Access Journals (Sweden)

    Poppy Ruliana

    2015-01-01

    Full Text Available The purpose of this study is to determine the communication strategy of marketing through public relations approach between hotel and community. The model used in this study is a Public Relations strategy planning model of Cutlip, Center & Broom (2009. Method used in this research is descriptive qualitative approach. Data were collected by doing participatory observation, in-depth interviews, documentary studies and triangulation. Data wrere analyzed through the stages of data reduction, data presentation, conclusion and verification. Result shows that the PR strategy planning model proposed by Cutlip, Center & Broom can support this research.

  8. Public Relations in the State Institutions from Galati

    Directory of Open Access Journals (Sweden)

    Daniela Aurelia Tanase Popa

    2016-06-01

    Full Text Available The paper aims at identifying and analyzing specific public relations activities in various state institutions from Galati in order to shape a PR typological profile in this geographic area. From the methodological point of view, the paper is based on in-depth interview technique for data collection and content analysis as a method of interpretation. The purpose of this qualitative study is to investigate the professional activity of the specialist in public relations in state institutions in Galati and achieving it was made possible through a structured interview guide on three indicators: professional environment, typological profile, professional responsibility.

  9. Index of Laser Program publications and related reports, 1983

    International Nuclear Information System (INIS)

    1984-05-01

    This document provides a listing of titles and authors of publications from the LLNL Laser Program during calendar year 1983. It is presented as an aid for researchers in the field who may not otherwise have access to a full listing of laser-related work done at LLNL. The intent is to provide a brief and concise listing. Publications are classified by subject, but cross references are not supplied and those documents which logically fall in more than one category may not appear to be in the obvious location. We recognize that gaining access to the publications may be difficult, and have appended a listing of libraries that have microfiche copies of one or more years of LLNL Laser Program publications

  10. Folate Deficiency Could Restrain Decidual Angiogenesis in Pregnant Mice

    Directory of Open Access Journals (Sweden)

    Yanli Li

    2015-08-01

    Full Text Available The mechanism of birth defects induced by folate deficiency was focused on mainly in fetal development. Little is known about the effect of folate deficiency on the maternal uterus, especially on decidual angiogenesis after implantation which establishes vessel networks to support embryo development. The aim of this study was to investigate the effects of folate deficiency on decidual angiogenesis. Serum folate levels were measured by electrochemiluminescence. The status of decidual angiogenesis was examined by cluster designation 34 (CD34 immunohistochemistry and the expression of angiogenic factors, including vascular endothelial growth factor A (VEGFA, placental growth factor (PLGF, and VEGF receptor 2 (VEGFR2 were also tested. Serum levels of homocysteine (Hcy, follicle stimulating hormone (FSH, luteinizing hormone (LH, prolactin (PRL, progesterone (P4, and estradiol (E2 were detected by Enzyme-linked immunosorbent assay. The folate-deficient mice had a lower folate level and a higher Hcy level. Folate deficiency restrained decidual angiogenesis with significant abnormalities in vascular density and the enlargement and elongation of the vascular sinus. It also showed a reduction in the expressions of VEGFA, VEGFR2, and PLGF. In addition, the serum levels of P4, E2, LH, and PRL were reduced in folate-deficient mice, and the expression of progesterone receptor (PR and estrogen receptor α (ERα were abnormal. These results indicated that folate deficiency could impaire decidual angiogenesis and it may be related to the vasculotoxic properties of Hcy and the imbalance of the reproductive hormone.

  11. Environmental remediation: Addressing public concerns through effective community relations

    International Nuclear Information System (INIS)

    Davis, S.; Heywood, J.; Wood, M.B.; Arellano, M.; Pfister, S.

    1998-01-01

    The public's perception of risk drives their response to any potential environmental remediation project. Even if the actual environmental and health risks may be relatively low, public perception of high risk may doom the project to an uphill struggle characterized by heated public meetings, negative media coverage, reluctant regulators, project delays and increased costs. The ultimate Catch 22 in such a case is that the contamination remains in-place until the public drama is concluded. This paper explores the development and implementation of a Community Relations Plan for the clean up of a Manufactured Gas Plant (MGP) site owned and operated by corporate predecessors of Arizona Public Service Company (APS) near the turn of the century. The unique challenges associated with this project were that the former MGP was located in downtown Phoenix at the site of a future federal courthouse. Although the MGP site had been under investigation for some time, the clean-up schedule was driven by a tight courthouse construction schedule. Compounding these challenges were the logistics associated with conducting a large-scale cleanup in a congested, highly visible downtown location. An effective Community Relations Plan can mean the difference between the success and failure of an environmental remediation project. Elements of an effective plan are: identifying key stakeholders and involving them in the project from the beginning; providing timely information and being open and honest about the potential environmental and health risks; involving your company's community relations and media staff; and educating affected company employees. The Community Relations Plan developed for this project was designed to alleviate public concern about potential risks (perceived or real) associated with the project by keeping key stakeholders informed of all activities well in advance

  12. The public relations in the public administration of the Republic of Srpska

    Directory of Open Access Journals (Sweden)

    Vranješ Nevenko

    2016-01-01

    Full Text Available The Public administration the Republic of Srpska is finally becoming a service to the citizens and businesses as an instrument which meets their needs. Even though some inequalities still exist in communication between public and administration, there is an opinion in the world today that the public has a right to be informed about all activities of funded subjects including the state administration. The Transparency of conducting administrative activities is regulated by law and it is also a subject of reforms, especially on the way to achieve a modern administration and European integration. The aim of this paper is to describe the system of the Public Relations in the Public administration of the Republic of Srpska. The authors of the paper discuss about theoretical importance of public relations, with special emphasis on the process of the legal access to information in the Republic of Srpska and current organizational capacities of the communication with public in the state administration of the Republic of Srpska.

  13. Effectively selling astronomy to the public -- fusing lessons learned from education, entertainment, advertising and public relations

    Science.gov (United States)

    Pallone, Arthur; Day, Jacque

    2010-03-01

    A great celestial story is only as effective as the teller of the tale. With passion and knowledge at the helm, we must search for ways to pass on enthusiasm to others while conveying sound science. Based on our experiences, we present an integrated approach -- one that borrows elements from education, entertainment, advertising, and public relations -- to choose an event, hook and keep the public's attention while making them want more, and provide some tips for increasing media presence.

  14. Power station design and public relations - association with the citizen

    International Nuclear Information System (INIS)

    Eiteneyer, H.

    1977-01-01

    The series of questions concerning public relations, connected with the realization of power plant construction projects will be discussed before the background of the public requirement of electricity supply corporations. It will be explained that public relation cannot be seen as an instrument, having the purpose to inform about 'good or bad' of power plant designs and construction intentions. PR is more a constitutive element of economy policy. Transparent, clear information of the citizen about power plant projects, and power plant related procedures should be their targets. This signifies a distance from just technical presentation. PR must develop in the direction to active corporational strategy, taking psychological- and social psychological influences into consideration. Statements will be made in regard to the dialogue between power plant advocates and power plant opponents. The special responsibility of the public electricity supply corporations for an always sufficient, safe and economical supply to the consumer, will be pointed out. Better information of the public in this regard is a necessary requirement. (orig.) [de

  15. Angiogenesis, Thrombospondin-1 and Cervical Carcinogenesis

    Directory of Open Access Journals (Sweden)

    Ming-Ping Wu

    2005-06-01

    Full Text Available Angiogenesis, the growth of new vessels from existing vasculature, plays an essential role in tumor development. The process involves interaction among cancer cells, endothelial cells, and components of the extracellular matrix, and is regulated by the balance of angiogenesis activators and angiogenesis inhibitors. This review profiles some fundamental concepts of angiogenesis, the importance of angiogenesis in cervical neoplasm, and the role of thrombospondin-1 as an angiogenesis inhibitor in cervical carcinogenesis. The usefulness and limitations of microvessel density in evaluation of angiogenic status are also discussed. Recent research and evolving concepts have led to a paradigm shift in anticancer therapy, from conventional cancer-centered chemotherapy to angiogenic or “metronomic” chemotherapy and/or combined angiogenesis inhibitors. The epigenetic strategy, which views the tumor system as a whole, transcends the cancer gene-centered approach.

  16. Modelling Tumor-induced Angiogenesis: Combination of Stochastic Sprout Spacing and Sprout Progression

    Directory of Open Access Journals (Sweden)

    Hosseini F.

    2017-09-01

    Full Text Available Background: Angiogenesis initiated by cancerous cells is the process by which new blood vessels are formed to enhance oxygenation and growth of tumor. Objective: In this paper, we present a new multiscale mathematical model for the formation of a vascular network in tumor angiogenesis process. Methods: Our model couples an improved sprout spacing model as a stochastic mathematical model of sprouting along an existing parent blood vessel, with a mathematical model of sprout progression in the extracellular matrix (ECM in response to some tumor angiogenic factors (TAFs. We perform simulations of the siting of capillary sprouts on an existing blood vessel using finite difference approximation of the dynamic equations of some angiogenesis activators and inhibitors. Angiogenesis activators are chemicals secreted by hypoxic tumor cells for initiating angiogenesis, and inhibitors of the angiogenesis are chemicals that are produced around every new sprout during tumor angiogenesis to inhibit the formation of further sprouts as a feedback of sprouting in angiogenesis. Moreover, for modelling sprout progression in ECM, we use three equations for the motility of endothelial cells at the tip of the activated sprouts, the consumption of TAF and the production and uptake of Fibronectin by endothelial cells. Results: Coupling these two basic models not only does provide a better time estimation of angiogenesis process, but also it is more compatible with reality. Conclusion: This model can be used to provide basic information for angiogenesis in the related studies. Related simulations can estimate the position and number of sprouts along parent blood vessel during the initial steps of angiogenesis and models the process of sprout progression in ECM until they vascularize a tumor.

  17. Media and public relation. Part of emergency planning

    International Nuclear Information System (INIS)

    Jurkovic, I.A.; Debrecin, N.; Feretic, D.; Skanata, D.

    2000-01-01

    In the event of an emergency, media relation should be considered as one of the most important functions in emergency management. Individuals should be trained to be able to provide factual information to the media and the citizens during nuclear emergencies. Media can be also acquainted with the scope, ways and means of providing information related to nuclear emergencies during the predefined and regular media training or workshops, or as a part of regular training routine of involved organizations and institutions. This paper is through various approaches trying to present one of the possible ways that media and public relation can be treated during the emergencies and inside the developed emergency plans and procedures. It also represents an idea, based on the authors' experience, on a way in which things can be organized in the Croatian Technical Support Center when it comes to the media/public relation issue. (author)

  18. International Public Relations in the EU: Development Cooperation Public Opinion and Public Policies

    Directory of Open Access Journals (Sweden)

    Victor Negrescu

    2011-05-01

    Full Text Available In the context of the growing importance of the cooperation for development in the European Union and the appearance of a common growing public opinion agreement supporting this kind of initiatives, it is necessary to understand if we can talk today about a true common European consensus. Still covered on intergovernmental level and considered to be a part of the national foreign policies, EU development aid is still far from reaching the maximum of its efficiency. In this paper we try to introduce a new evaluation method of the cooperation for development policies and interpretation of the degree of communitarisation of the national policies that will enable us to appreciate the stages that have to be completed by the member countries but also by the EU to realize a completely uniform European assistance strategy and of the activities, so necessary for raising the efficiency of the funds allocated by the EU, but also in the perspective of achieving the Millennium Development Goals.

  19. Evaluation of poultry processing practices, related public health laws ...

    African Journals Online (AJOL)

    Background public health regulations related to poultry production and processing as provided within the Meat Law (1968), Food and Drug Act (1974) and Animal Diseases (Control) Act (1988) were also assessed for gaps that could compromise quality and safety of poultry products in Nigeria. The diseases detectable at ...

  20. Public Relations Strategies and the Implementation of the ...

    African Journals Online (AJOL)

    It is against this backdrop that this paper examines how public relations strategies can be used to achieve the millennium developments goals. The millennium Development Goals are drawn from the actions and targets contained in the Millennium Declaration that was adopted by 189 Nations signed by 147 heads of state ...

  1. Evaluating internal public relations using the critical incident technique

    NARCIS (Netherlands)

    Koning, K.H.; de Jong, Menno D.T.; van Vuuren, Hubrecht A.

    2015-01-01

    Although the critical incident technique (CIT) is one of the current methods in communication audits, little is known about the way it works. The validity of the CIT in the context of internal public relations depends on 3 assumptions: that participants can describe discrete communication events,

  2. Evaluation of poultry processing practices, related public health laws ...

    African Journals Online (AJOL)

    Evaluation of poultry processing practices, related public health laws and diseases of chickens at slaughter: A pilot study in Kaduna state. ... The PDF file you selected should load here if your Web browser has a PDF reader plug-in installed (for example, a recent version of Adobe Acrobat Reader). If you would like more ...

  3. A Balanced Scorecard Approach to Public Relations Management Assessment.

    Science.gov (United States)

    Fleisher, Craig S.; Mahaffy, Darren

    1997-01-01

    Describes a new managerial approach to assessing public relations/communications (PR/C) performance using a "balanced scorecard." Reviews the current state of PR/C management assessment; illustrates the balanced scorecard framework; highlights its strengths and weaknesses; describes the process of applying the scorecard to PR/C units;…

  4. Teaching Teamwork to Public Relations Students: Does It Matter?

    Science.gov (United States)

    Baker-Schena, Lori

    2011-01-01

    Purpose: The first purpose of this study was to determine the extent to which students in university capstone public relations classes who receive teamwork training demonstrate effective team behaviors, produce quality work, experience satisfaction in the teamwork process, and engender client satisfaction. The second purpose was to determine the…

  5. Digital Public Relations: E-Marketing's Big Secret

    Science.gov (United States)

    Gifford, Janet

    2010-01-01

    Online programs and courses are established presences in higher education, and so are processes such as online registration. Prospective students routinely turn to the web for information to help them decide on the most appropriate programs for their situation. Digital public relations (digital PR) is rapidly becoming one of the cornerstones of an…

  6. A first look for parameters of public relations in Europe

    NARCIS (Netherlands)

    van Ruler, A.A.; Vercic, D.; Buetschi, G.; Flodin, B.

    2004-01-01

    Teaching of public relations in Europe is largely U.S. oriented. A study has been conducted to determine whether this also applies to the practical and academic approaches in this area. A Delphi panel, consisting of experts in research, education, or both from countries in Europe, identified four

  7. "In-Awareness" Approach to International Public Relations.

    Science.gov (United States)

    Zaharna, R. S.

    2001-01-01

    Presents a three-tiered framework intended to expose hidden cultural assumptions and expectations that plague international public relations. Notes the country profile outlines what may be feasible within a particular country; the cultural profile speaks to what may be effective in that country; and the communication profile delineates…

  8. Public relations research: European and international perspectives and innovations

    NARCIS (Netherlands)

    Zerfass, A.; van Ruler, B.; Sriramesh, K.

    2008-01-01

    This volume is a major contribution to the trans-national debate on public relations research and communication management. It presents dominant concepts and findings from the scientific community in Germany in English language. At the same time, the compilation contains a selection of the most

  9. Beyond the Borders: Principles of International Public Relations.

    Science.gov (United States)

    Crowther, Connie

    1994-01-01

    Advice on international public relations for colleges and universities includes focusing efforts on one country or region at a time; researching the market and media outlets; involving faculty and administrators; using the local language; careful budgeting; providing photographs and copy; focusing story ideas; considering politics; and considering…

  10. Investigation on public knowledge, attitude and practices related to ...

    African Journals Online (AJOL)

    Ethiop. Vet. J., 2016, 20 (1), 67-78. Investigation on public knowledge, attitude and practices related to pet management and zoonotic canine diseases in Addis Ababa, Ethiopia ... husbandry and diseases control practices in Addis Ababa. ... meat to their dogs and 79.3% of the owners obtained the meat from local unlicensed.

  11. Public relations and marketing of Nigerian School Library Media ...

    African Journals Online (AJOL)

    Some of the channels of the public relations and marketing of information resources and services of SLMC that were discussed in the paper include: press release, letter writing, house organ, booklets, bulletin and notice boards, and electronic / text messages, social media. The study concludes that information should be ...

  12. Public Knowledge, Perceptions and Practices in Relation to ...

    African Journals Online (AJOL)

    Background: We report public knowledge, perceptions and practices on selected infectious diseases in Tanzania using a study done in Babati district, and identify policy related messages in light of health promotion strategies instituted for communicable disease control. Methods: Data were gathered through ...

  13. Public perception of global warming and related environmental ...

    African Journals Online (AJOL)

    Public perception of global warming and related environmental issues in Kano city, Nigeria. ... Conclusion The high awareness about global warming needs to be reinforced through use of media to encourage advocacy and community action towards preventing global warming and ensuring environmental sustainability.

  14. Crisis Communication and Management: Surviving a Public Relations Crisis

    Science.gov (United States)

    Eramo, Eric M.

    2009-01-01

    Crisis management, or crisis communication, is never a good thing for a business to experience. It is, however, a public relations' professional moment to shine and put their honed skills to good use. A good crisis management plan is not only action during the crisis but preparation and reflection. Hiring a PR firm that deals with crisis…

  15. The Effects of Public Relations Messages about Corporate Social Responsibility.

    Science.gov (United States)

    Reeves, Byron; Ferguson-Dethorne, Mary Ann

    To determine whether public relations messages generated from three different corporate social responsibility philosophies would have different effects on attitudes and behavioral intentions toward a corporation, 147 college students participated in an experiment. The three social responsibility philosophies were defined as: a "profit" concept,…

  16. Reputation Management: The New Face of Corporate Public Relations?

    Science.gov (United States)

    Hutton, James G.; Goodman, Michael B.; Alexander, Jill B.; Genest, Christina M.

    2001-01-01

    Presents an empirical study of the Fortune 500 companies suggesting that "reputation management" is gaining ground as a driving philosophy behind corporate public relations. Finds some interesting correlations between reputation and specific categories of spending. Concludes that if reputation management is the new face of corporate…

  17. Breast Tumor Angiogenesis and Tumor-Associated Macrophages: Histopathologist's Perspective

    Directory of Open Access Journals (Sweden)

    Ewe Seng Ch'ng

    2011-01-01

    Full Text Available Much progress has been made since the conceptualization of tumor angiogenesis—the induction of growth of new blood vessels by tumor—as a salient feature of clinically significant primary or metastatic cancers. From a practicing histopathologist's point of view, we appraise the application of this concept in breast cancer with particular reference to the evaluation of proangiogenic factors and the assessment of new microvessels in histopathological examination. Recently, much focus has also been centered on the active roles played by tumor-associated macrophages in relation to tumor angiogenesis. We review the literature; many data supporting this facet of tumor angiogenesis were derived from the breast cancer models. We scrutinize the large body of clinical evidence exploring the link between the tumor-associated macrophages and breast tumor angiogenesis and discuss particularly the methodology and limitations of incorporating such an assessment in histopathological examination.

  18. Perception of Journalists on the Role of Public Relations

    Directory of Open Access Journals (Sweden)

    Nicoleta Grasu

    2014-12-01

    Full Text Available The relations with the media are the main activity performed by the public relations specialists for maintaining a positive image of the organization they represent. This relation between public relations and journalists can become, sometimes, a conflicting one, but both of them admit that they need each other. On the on hand, communication specialists try to satisfy journalists‟ information needs, and on the other hand, the journalists satisfy PR-ists needs to put in a favorable light the organization they represent. In this study we intend to identify the opinion of journalists on public relations and spokesperson in relation to the work of the journalist and also to identify the reasons of journalists for not trust the profession of media relationist. The questionnaire was applied in the range 1 to 20 March 2014. The sampling was non-probabilistic one, the only criterion for selection of respondents being the status of journalist. The questionnaire answered 50 journalists from central and local press. In terms of the positions held by the respondents, the sample is as follows: 12% are director, 24% have editor function, 14% are editors and 34% are reporters.

  19. Malaysian public perception towards nuclear power energy-related issues

    Science.gov (United States)

    Misnon, Fauzan Amin; Hu, Yeoh Siong; Rahman, Irman Abd.; Yasir, Muhamad Samudi

    2017-01-01

    Malaysia had considered nuclear energy as an option for future electricity generation during the 9th Malaysia Development Plan. Since 2009, Malaysia had implemented a number of important preparatory steps towards this goal, including the establishment of Nuclear Power Corporation of Malaysia (MNPC) as first Nuclear Energy Programme Implementing Organization (NEPIO) in Malaysia. In light of the establishment of MNPC, the National Nuclear Policy was formulated in 2010 and a new comprehensive nuclear law to replace the existing Atomic Energy Licensing Act (Act 304) is currently in the pipeline. Internationally, public acceptance is generally used to gauge the acceptance of nuclear energy by the public whenever a government decides to engage in nuclear energy. A public survey was conducted in between 14 March 2016 to 10 May 2016 focusing on the Malaysian public acceptance and perception towards the implementation of nuclear energy in Malaysia. The methodology of this research was aim on finding an overview of the general knowledge, public-relation recommendation, perception and acceptance of Malaysian towards the nuclear power development program. The combination of information gathered from this study can be interpreted as an indication of the complexity surrounding the development of nuclear energy and its relationship with the unique background of Malaysian demography. This paper will focus mainly on energy-related section in the survey in comparison with nuclear energy.

  20. Tumor angiogenesis--a new therapeutic target in gliomas

    DEFF Research Database (Denmark)

    Lund, E L; Spang-Thomsen, M; Skovgaard-Poulsen, H

    1998-01-01

    Tumor growth is critically dependent on angiogenesis, which is sprouting of new vessels from pre-existing vasculature. This process is regulated by inducers and inhibitors released from tumor cells, endothelial cells, and macrophages. Brain tumors, especially glioblastoma multiforme, have...... significant angiogenic activity primarily by the expression of the angiogenic factor VEGF Anti-angiogenic therapy represents a new promising therapeutic modality in solid tumors. Several agents are currently under evaluation in clinical trials. The present review describes the principal inducers...... and inhibitors of angiogenesis in tumors and summarizes what is known about their mechanisms of action in relation to CNS tumors. Potential areas for clinical use are also discussed....

  1. Authors' opinions on publication in relation to annual performance assessment.

    Science.gov (United States)

    Walker, Robin L; Sykes, Lindsay; Hemmelgarn, Brenda R; Quan, Hude

    2010-03-09

    In the past 50 years there has been a substantial increase in the volume of published research and in the number of authors per scientific publication. There is also significant pressure exerted on researchers to produce publications. Thus, the purpose of this study was to survey corresponding authors in published medical journals to determine their opinion on publication impact in relation to performance review and promotion. Cross-sectional survey of corresponding authors of original research articles published in June 2007 among 72 medical journals. Measurement outcomes included the number of publications, number of authors, authorship order and journal impact factor in relation to performance review and promotion. Of 687 surveys, 478 were analyzed (response rate 69.6%). Corresponding authors self-reported that number of publications (78.7%), journal impact factor (67.8%) and being the first author (75.9%) were most influential for their annual performance review and assessment. Only 17.6% of authors reported that the number of authors on a manuscript was important criteria for performance review and assessment. A higher percentage of Asian authors reported that the number of authors was key to performance review and promotion (41.4% versus 7.8 to 22.2%). compared to authors from other countries. The number of publications, authorship order and journal impact factor were important factors for performance reviews and promotion at academic and non-academic institutes. The number of authors was not identified as important criteria. These factors may be contributing to the increase in the number of authors per publication.

  2. Authors' opinions on publication in relation to annual performance assessment

    Directory of Open Access Journals (Sweden)

    Hemmelgarn Brenda R

    2010-03-01

    Full Text Available Abstract Background In the past 50 years there has been a substantial increase in the volume of published research and in the number of authors per scientific publication. There is also significant pressure exerted on researchers to produce publications. Thus, the purpose of this study was to survey corresponding authors in published medical journals to determine their opinion on publication impact in relation to performance review and promotion. Methods Cross-sectional survey of corresponding authors of original research articles published in June 2007 among 72 medical journals. Measurement outcomes included the number of publications, number of authors, authorship order and journal impact factor in relation to performance review and promotion. Results Of 687 surveys, 478 were analyzed (response rate 69.6%. Corresponding authors self-reported that number of publications (78.7%, journal impact factor (67.8% and being the first author (75.9% were most influential for their annual performance review and assessment. Only 17.6% of authors reported that the number of authors on a manuscript was important criteria for performance review and assessment. A higher percentage of Asian authors reported that the number of authors was key to performance review and promotion (41.4% versus 7.8 to 22.2%. compared to authors from other countries. Conclusions The number of publications, authorship order and journal impact factor were important factors for performance reviews and promotion at academic and non-academic institutes. The number of authors was not identified as important criteria. These factors may be contributing to the increase in the number of authors per publication.

  3. Efforts in Public Relations on Fusion in Europe

    Science.gov (United States)

    Ongena, J.; van Oost, G.

    2001-10-01

    An overview will be given of different published materials currently in use in Europe for public relations on fusion. We will also present a CD-ROM for individual and classroom use, containing (i) a general background on different energy forms, (ii) general principles of fusion, (iii) current research efforts and (iv) future prospects of fusion. This CD-ROM is currently in English, German, French, Spanish, Portuguese and Italian. Fusion posters developed in collaboration with CPEP in Dutch, French, German, Italian, Spanish and Portuguese will be shown. Several new brochures and leaflets intended to increase the public awareness on fusion in Europe will be on display.

  4. Public relations in risk communication: risk pr. The importance of public relations for risk communication; Public Relations in der Risikokommunikation: Risiko-PR. Die Bedeutung von Public Relations fuer die Risikokommunikation

    Energy Technology Data Exchange (ETDEWEB)

    Lehmann, K.

    2001-07-01

    Risks have become a central problem of our time, as is reflected in concepts like 'society at risk' and 'anti-technological attitude', in group protest against risks and against those who cause them, and last but not least in the critical attitude of the media. Against this background, organisations must needs enter the public discussion and be able to communicate professionally and convincingly in order to ensure their own success and further existence. The book describes the basic problems of risk research and risk communications and discusses inhowfar, and how, public relations strategies and instruments can help here. [German] Risiken werden verstaerkt zum Problem unserer Zeit. Das belegen nicht nur Begriffe wie 'Risikogesellschaft' und 'Technikfeindlichkeit', die in letzter Zeit an Bedeutung gewonnen haben, sondern auch und vor allem nachhaltige Proteste von engagierten Gruppierungen gegen Risiken und deren Verursacher oder auch die kritische Berichterstattung der Medien. Vor diesem Hintergrund ist es fuer Organisationen erforderlich, in die oeffentliche Auseinandersetzung um Risiken einzusteigen und hier professionell und ueberzeugend zu kommunizieren, um den Organisationserfolg und Organisationsbestand zu sichern. Die vorliegende Arbeit beschreibt die Grundprobleme der Risikoforschung und Risikokommunikation und diskutiert, ob und inwieweit Public Relations bei der Loesung dieser Probleme helfen koennen, da insbesondere Public Relations gezielt Strategien und Instrumente nutzen, um beispielsweise den Wissensstand der Oeffentlichkeit zu verbessern und den Dialog mit relevanten Teiloeffentlichkeiten zu foerdern. (orig.)

  5. The rule on granting subsidies for public relations

    International Nuclear Information System (INIS)

    1980-01-01

    The regulation is set up under the provisions of the law concerning the proper execution of subsidy budgets and the ordinance for enforcing the law, to carry these provisions into effect. The subsidies for public relations under the ordinance for enforcing the law concerning the special account for the measures of promoting power source development are delivered according to the provisions of the regulation as well as the law concerning the proper execution of subsidy budgets and the ordinance for enforcing the law. Basic terms are defined, such as nuclear power generating facilities; facilities related to nuclear power generation; place of business, etc. The ministers and directors of departments concerned deliver the subsidies for public relations to a prefecture where nuclear power generating facilities and related facilities are established or expected to be established, to cover all or a part of expenses necessary for the popularization of knowledges on nuclear power generation. The amounts of subsidies for public relations paid to a prefecture in each fiscal year are from 6 to 18 million yen. An application for such subsidies shall be filed by an applicant prefecture to the ministers or directors of departments concerned according to the form prescribed. The terms, conditions and decision of the delivery of subsidies are stipulated, respectively. (Okada, K.)

  6. Unorthodox angiogenesis in skeletal muscle.

    Science.gov (United States)

    Egginton, S; Zhou, A L; Brown, M D; Hudlická, O

    2001-02-16

    The morphological pattern of angiogenesis occurring in mature, differentiated skeletal muscle in response to chronically increased muscle blood flow, muscle stretch or repetitious muscle contractions was examined to determine (a) whether capillary neoformation follows the generally accepted temporal paradigm, and (b) how the growth pattern is influenced by mechanical stimuli. Adult rats were treated for a maximum of 14 days either with the vasodilator prazosin, to elevate skeletal muscle blood flow, or underwent surgical removal of one ankle flexor, to induce compensatory overload in the remaining muscles, or had muscles chronically stimulated by implanted electrodes. Extensor digitorum longus and/or extensor hallucis proprius muscles were removed at intervals and processed for electron microscopy. A systematic examination of capillaries and their ultrastructure characterised the sequence of morphological changes indicative of angiogenesis, i.e., basement membrane disruption, endothelial cell (EC) sprouting and proliferation [immunogold labelling after bromodeoxyuridine (BrdU) incorporation]. Capillary growth in response to increased blood flow occurred by luminal division without sprouting or basement membrane (BM) breakage. In stretched muscles, EC proliferation and abluminal sprouting gave rise to new capillaries, with BM loss only at sprout tips. These distinct mechanisms appear to be additive as in chronically stimulated muscles (increased blood flow with repetitive stretch and shortening during muscle contractions) both forms of capillary growth occurred. Endothelial cell numbers per capillary profile, mitotic EC nuclei, and BrdU labelling confirmed cell proliferation prior to overt angiogenesis. Physiological angiogenesis within adult skeletal muscle progresses by mechanisms that do not readily conform to the consensus view of capillary growth, derived mainly from observations made during development, pathological vessel growth, or from in vitro systems. The

  7. Salaries of New Superintendents: A Public Relations Concern for Many Public School Boards

    Science.gov (United States)

    Young, I. Phillip

    2007-01-01

    Salaries for new superintendents form a highly visible factor that has direct implications for school-community public relations. To provide a means for guiding school board members and to provide a format for justifying salaries, a model is presented that serves both purposes. Within this model, attention is afforded to specifying a relevant…

  8. [Needs on information related to influenza pandemic by the public].

    Science.gov (United States)

    Hao, Ai-hua; Cai, Yan-shan; Feng, Wen-ru; Wang, Ming

    2009-11-01

    To understand the information needs on human infection with avian influenza (H5N1), A (H1N1) and influenza pandemic in different time periods and create well-targeted messages by the public, so as to develop communication with the public effectively when human infection with avian influenza (H5N1), A (H1N1) and influenza pandemic occur. Data were collected through questionnaire over telephone calls. The questionnaire was self-designed, revised after pilot testing. The effective response rate in this telephone survey was 54.33%, higher than those in Beijing and Shanghai. The respondents felt that government's propaganda during the influenza virus-active period was more helpful and instructive than those in the period when influenza was relatively inactive (chi(2) = 17.41, P = 0.000). Trust to the government by the public was higher in the influenza virus-active than in the relatively inactive period (chi(2) = 8.15, P = 0.004). As to the information needs, the respondents reflected that during the time period of relative influenza inactivity, they viewed the basic knowledge of human infection with avian influenza (H5N1) as their top priority, while in the influenza virus-active period, the feasible preventive measures was their top priority. The pandemic-related information needs in the influenza virus-active period and in the time period of relative influenza inactivity were similar, demonstrating that the respondents had no perceptual knowledge of influenza pandemic and had poor awareness on the pandemic. The respondents were not used to wear a mask to cover their mouths and noses when sneezing, but were quite knowledgeable about the following preventive measures as: avoid going out and at the crowded areas, wash hands frequently etc. Around 2% to 6% of the respondents did not have any information needs. The response rate in this telephone survey was fairly high, indicating that telephone survey was well accepted by Guangzhou residents. The public was satisfied

  9. Vascular endothelial growth factors and angiogenesis in eye disease

    NARCIS (Netherlands)

    Witmer, A. N.; Vrensen, G. F. J. M.; van Noorden, C. J. F.; Schlingemann, R. O.

    2003-01-01

    The vascular endothelial growth factor (VEGF) family of growth factors controls pathological angiogenesis and increased vascular permeability in important eye diseases such as diabetic retinopathy (DR) and age-related macular degeneration (AMD). The purpose of this review is to develop new insights

  10. Prognostic implication of apoptosis and angiogenesis in cervical uteri cancer

    International Nuclear Information System (INIS)

    Zaghloul, Mohamed S.; El Naggar, Mervat; El Deeb, Amany; Khaled, Hussein; Mokhtar, Nadia

    2000-01-01

    Purpose: A retrospective study was performed to investigate the relationship between spontaneous apoptosis and angiogenesis uterine cervix squamous cell carcinoma patients. The prognostic value of each (and both) of these biologic parameters was also tested. Methods and Materials: The pathologic materials of 40 cervical uteri squamous cell carcinoma patients were examined and immunohistochemically stained to determine the tumor angiogenesis (tumor microvascular score), using factor VIII-related antigen, and their tumor apoptotic index (AI), using the TdT-mediated dUTP nick end-labeling (TUNEL) method. Three patients were Stage I, 18 were Stage II, 15 were Stage III, and 4 were Stage IV (FIGO classification). All patients were treated with radical radiotherapy and all had follow-up for more than 2 years. Results: The mean AI was 15.1 ± 12.8, with a median of 8.3. The mean tumor microvascular score was 3 9.7 ± 14.4, with a median of 3 8. The patients' age and tumor grade did not seem to significantly affect the prognosis. On the other hand, AI and angiogenesis (tumor microvascular score) were of high prognostic significance. The 3-year disease-free survival (DFS) rate for the patients having AI above the median was 78% (confidence interval [CI] 69-87%), compared to 32% (CI 22-42%) for those having AI below the median. The DFS was 18% (CI 9-27%) for patients having an angiogenesis score above the median, while it was 86% (CI 78-94%) for those patients having a score below the median. Conclusion: Determination of both tumor microvascular score and AI can identify patients with the best prognosis of 100% DFS (with low angiogenesis score and high AI). Women with a high score and low AI had the worst prognosis (DFS = 3%, CI 1-5%). Moreover, high AI can compensate partially for the aggressive behavior of tumors showing a high rate of angiogenesis.

  11. Syndecan-4 shedding impairs macrovascular angiogenesis in diabetes mellitus

    Energy Technology Data Exchange (ETDEWEB)

    Li, Ran; Xie, Jun; Wu, Han; Li, Guannan; Chen, Jianzhou; Chen, Qinhua; Wang, Lian; Xu, Biao, E-mail: xubiao@medmail.com.cn

    2016-05-20

    Purpose: Syndecan-4 (synd4) is a ubiquitous heparan sulfate proteoglycan cell surface receptor that modulates cell proliferation, migration, mechanotransduction, and endocytosis. The extracellular domain of synd4 sheds heavily in acute inflammation, but the shedding of synd4 in chronic inflammation, such as diabetes mellitus (DM), is still undefined. We investigated the alterations of synd4 endothelial expression in DM and the influence of impaired synd4 signaling on angiogenesis in human umbilical vein endothelial cells (HUVECs), diabetic rats, synd4 null mice, and db/db mice. Material and methods: HUVECs were incubated with advanced glycation end products (AGEs). Western blot analysis was used to determine synd4 protein expression and ELISA was used to detect soluble synd4 fragments. The concentration of synd4 in the aortic endothelia of diabetic rats was detected by immunohistochemical staining. Aortic ring assays were performed to study the process of angiogenesis in the diabetic rats and in synd4 null and db/db mice. Recombinant adenoviruses containing the synd4 gene or null were constructed to enhance synd4 aortic expression in db/db mice. Results: Western blot analysis showed decreased expression of the synd4 extracellular domain in HUVECs, and ELISA detected increased soluble fragments of synd4 in the media. Synd4 endothelial expression in the aortas of diabetic rats was decreased. Aortic ring assay indicated impaired angiogenesis in synd4 null and db/db mice, which was partially reversed by synd4 overexpression in db/db mice. Conclusion: Synd4 shedding from vascular endothelial cells played an important role in the diabetes-related impairment of angiogenesis. -- Highlights: •Synd4 shedding from endothelial cells is accelerated under the stimulation of AGEs. •Extracellular domain of synd4 is diminished in the endothelium of DM rats. •Aortic rings of synd4 null mice showed impaired angiogenesis. •Overexpression of synd4 partly rescues macrovascular

  12. Analytical and critical thinking skills in public relations

    Directory of Open Access Journals (Sweden)

    Dalibor Jakus

    2014-12-01

    Full Text Available This article presents more or less independent reasons why analytical and critical thinking skills should be essential part of public relations. Generally, it is considered that the analytical and critical thinking skills are part of public relations, as well as creative thinking, but they should be considered separately and given the codes of ethics of the profession used as initial criteria. For the purpose of the study, in this article is presented the result of the survey in which determine importance of using analytical and critical thinking skills in the implementation of PR projects. The second aim in the survey was to identify the target audience and how they react to the placed information.

  13. Machismo, public health and sexuality-related stigma in Cartagena.

    Science.gov (United States)

    Quevedo-Gómez, María Cristina; Krumeich, Anja; Abadía-Barrero, César Ernesto; Pastrana-Salcedo, Eduardo; van den Borne, Hubertus

    2012-01-01

    This paper reports on an ethnographic study in Cartagena, Colombia. Over a seven-month fieldwork period, 35 men and 35 women between 15 and 60 years of age discussed the social context of HIV/AIDS through in-depth interviews, life histories and drawing. Participants considered the transgression of traditional gender roles as prescribed by machismo a major risk factor for HIV infection. In addition, they integrated public-health concepts of risk groups with these long-standing constructions of gender roles and sexuality-related stigma to create the notion of 'AIDS carriers'. The bricolage between machismo, public health and sexuality-related stigma that participants created and consequent preventive measures (based on an avoidance of sex with people identified as 'AIDS carriers') was a dynamic process in which participants were aware that changes in this particular interpretation of risk were necessary to confront the local epidemic.

  14. Public Relations ve společnosti Qlik.cz

    OpenAIRE

    Vrkočová, Pavlína Bc.

    2007-01-01

    Diplomová práce se zabývá aktivitami Public Relations ve vybrané organizaci. Teoretická část představuje stručný úvod do problematiky PR. Praktická část se zabývá definováním cílové skupiny a následně přípravou tiskové konference. V práci je také proveden výzkum, který přináší informace o možné budoucí strategii společnosti. Závěrečná kapitola je věnována zhodnocení projektu Public Relations a návrhům na zlepšení pro vybranou společnost.

  15. Public Support for Weight-Related Antidiscrimination Laws and Policies.

    Science.gov (United States)

    Hilbert, Anja; Hübner, Claudia; Schmutzer, Gabriele; Danielsdottir, Sigrun; Brähler, Elmar; Puhl, Rebecca

    2017-01-01

    Weight-related discrimination is prevalent and associated with health impairments for those who are targeted, which underscores the need of antidiscrimination legislation. This study is the first to examine public support of weight-related antidiscrimination laws or policies in Germany, compared to the US and Iceland. In a representative German population sample (N = 2,513), public support for general and employment-specific weight-related antidiscrimination policies, weight-based victimization, and weight bias internalization were measured through established self-report questionnaires. Half of the German population sample agreed with antidiscrimination policies. General antidiscrimination laws received lower support than employment-specific laws. Support for policies considering obesity a physical disability was greatest in Germany, whereas support for employment-specific antidiscrimination laws was lower in Germany than in the US and Iceland. Total support for weight-related antidiscrimination policies was significantly predicted by lower age, female gender, obese weight status, residence in West Germany, church membership, and readiness to vote in elections. German support for weight-related antidiscrimination policies is moderate. Increasing awareness about weight-related discrimination and laws prohibiting this behavior may help to promote policy acceptance. © 2017 The Author(s) Published by S. Karger GmbH, Freiburg.

  16. Public Support for Weight-Related Antidiscrimination Laws and Policies

    Directory of Open Access Journals (Sweden)

    Anja Hilbert

    2017-04-01

    Full Text Available Objective: Weight-related discrimination is prevalent and associated with health impairments for those who are targeted, which underscores the need of antidiscrimination legislation. This study is the first to examine public support of weight-related antidiscrimination laws or policies in Germany, compared to the US and Iceland. Methods: In a representative German population sample (N = 2,513, public support for general and employment-specific weight-related antidiscrimination policies, weight-based victimization, and weight bias internalization were measured through established self-report questionnaires. Results: Half of the German population sample agreed with antidiscrimination policies. General antidiscrimination laws received lower support than employment-specific laws. Support for policies considering obesity a physical disability was greatest in Germany, whereas support for employment-specific antidiscrimination laws was lower in Germany than in the US and Iceland. Total support for weight-related antidiscrimination policies was significantly predicted by lower age, female gender, obese weight status, residence in West Germany, church membership, and readiness to vote in elections. Conclusion: German support for weight-related antidiscrimination policies is moderate. Increasing awareness about weight-related discrimination and laws prohibiting this behavior may help to promote policy acceptance.

  17. Angiogenesis in life, disease and medicine

    Science.gov (United States)

    Carmeliet, Peter

    2005-12-01

    The growth of blood vessels (a process known as angiogenesis) is essential for organ growth and repair. An imbalance in this process contributes to numerous malignant, inflammatory, ischaemic, infectious and immune disorders. Recently, the first anti-angiogenic agents have been approved for the treatment of cancer and blindness. Angiogenesis research will probably change the face of medicine in the next decades, with more than 500 million people worldwide predicted to benefit from pro- or anti-angiogenesis treatments.

  18. Managing the relational character of public-private partnership contracts

    Directory of Open Access Journals (Sweden)

    Cvetković Predrag

    2015-01-01

    Full Text Available A public-private partnership contract has the character of a relational contract. Relational contracts are incomplete agreements governing transactions where the contracting parties have mutually agreed that it is impossible or economically inefficient to contractually define ex ante possible difficulties and contingencies in the contract implementation, nor the difficulties and contingencies underlying the ex post control of contract performance by a third entity (court or arbitration. Considering the methodology of managing relational contracts, it is essential that the theory of relational contracts does not advocate for the establishment of relational contracts as a separate category of contracts, with specifically designated contractual instruments. This theory defines the relational contract as a category which legitimizes 'the relational mode' of a particular contract. The methodology of relational contracts is important for contracts on public-private partnership as it ensures that the contractual relationship is aligned with the changes in the immediate environment where the PPP contract operates. The aforementioned alignment has two aspects. The first one is the ex ante aspect of the alignment which is primarily aimed at preventing the detrimental effect of such alignment to the public partner's interests. Therefore, the intent to prevent such an effect shall be taken into account when defining the criteria for the selection of the most favorable private partner and the best offer. At the same time, it is essential to establish verifiable standards for measuring the private partner performance in the phase of contract implementation. For this goal to be achieved, it is crucial to specify the subject matter of the private partner's obligations, to establish the priority rank of PPP project objectives, to elaborate on the specific requirements governing the eligibility of private partners to participate in the bidding process, to specify

  19. Strategic Public Relations and University Entrepreneurship in Present European Context

    Directory of Open Access Journals (Sweden)

    Andreea RĂCEANU

    2016-05-01

    Full Text Available Mostly theoretical and following a descriptive - normative logic, with a specific focus on the models of higher education institutions and practices, the present paper addresses the subject of entrepreneurship within higher education area, in relation with current European policy context regarding higher education and university entrepreneurship. It proposes a strategic public relations framework as an integrating effective approach for actual opportunities and challenges that universities deal with presently. Various theoretical approaches and concrete actions emerged, from the complex perspectives of triple helix (organic relationships and interactions between universities, industry and government to particular aims regarding the development of knowledge-based economy or to the European Union knowledge triangle initiatives (education-research-innovation. The role of universities is expected to be broader and its actions should be characterized by both responsibility and pragmatism within the context of sustainable decision making. However, mostly in practice, there are limitations and criticism regarding a convergent model of entrepreneurial university, even more in relation with issues related to ethics of teaching and research and especially for universities with social and humanistic profiles. In this context, a viable solution could come from the area of public relations, undertaken in their most advanced form: as strategic approach linking decision making processes, stakeholders’ needs and interests and assuming long term responsibility. The main aim and originality component of this paper is to propose and support such an approach presented both verbally and trough graphical modelling.

  20. A Comparative Analysis of Internal Communication and Public Relations Audits. State of the Art.

    Science.gov (United States)

    Dozier, David M.; Hellweg, Susan A.

    A review of current literature regarding the state of the art in the conduct of internal communication and public relations audits by public relations practitioners reveals that these two related measurement activities are of considerable importance to the practice of public relations. Public relations audits are concerned with exploratory…

  1. Public relations in the State Office for Nuclear Safety

    International Nuclear Information System (INIS)

    Prochazkova, Radka

    2000-01-01

    The State Office for Nuclear Safety (SONS) is a government agency. The Office is headed by a chairperson who is appointed by the Czech Government. The Office has got its own budget and reports directly to the Czech Government. SONS was established in 1993 and continued activities of the former Czechoslovak Commission for Atomic Energy. SONS main activity is the central administration and supervision of the peaceful utilization of nuclear power and ionizing radiation and in the field of radiation protection. SONS is regulated mainly by the Atomic Act. A separate department of Public Relations was established last year in SONS especially due to the enactment of the statutory obligation of government agencies to render information. Basic P.R. communication means in the field of external communication include: Information Center; Internet; Press Releases; Publications - publishing regularly or for topical events; Seminars; Meetings; Press conferences; Editorial articles; Answering questions

  2. Angiogenesis during mandibular distraction osteogenesis.

    Science.gov (United States)

    Rowe, N M; Mehrara, B J; Luchs, J S; Dudziak, M E; Steinbrech, D S; Illei, P B; Fernandez, G J; Gittes, G K; Longaker, M T

    1999-05-01

    Recruitment of a blood supply is critical for successful bone induction and fracture healing. Despite the clinical success of distraction osteogenesis (DO), an analysis of angiogenesis during membranous bone DO has not been performed. The purpose of this study was to evaluate the temporal and spatial pattern of angiogenesis during mandibular DO. The right hemimandible of adult male rats was osteotomized, and a customized distraction device was applied. Following a 3-day latency period, distraction was begun at a rate of 0.25 mm twice daily for 6 days (3.0 mm total; 12% increase in mandibular length). Three animals each were sacrificed on days 2, 4, and 6 of distraction (D1, D2, and D3 respectively), or after 1, 2, or 4 weeks of consolidation (C1, C2, and C3 respectively). Two experienced pathologists reviewed the regenerate histology, and angiogenesis was assessed by counting the number of blood vessels per intermediate-power field (IPF). Statistical analysis was performed using analysis of variance, with p response during the early stages of distraction (D1). On average, 31.5+/-7.9 vessels were noted in each IPF examined during this time point. The number of blood vessels in the distraction regenerate decreased significantly during the later distraction time points, with approximately 14.0+/-2.0 and 14.7+/-3.5 blood vessels per IPF in sections obtained after days 4 and 6 of distraction (D2, D3) respectively. However, blood vessels at these time points took on a more mature histological pattern. During the consolidation period, the number of blood vessels noted in the regenerate decreased with 8.0+/-2.6, 9.3+/-2.1, and 4.0+/-2.0 vessels per IPF in sections obtained after 1, 2, or 4 weeks of consolidation (C1, C2, C3) respectively (p response associated with mandibular DO occurs primarily during the early stages of distraction. The authors hypothesize that as distraction continues, newly formed vessels likely undergo consolidation, thus forming more mature vessels

  3. Public relations campaign for shipping spent nuclear fuel

    International Nuclear Information System (INIS)

    Bushee, Tom

    1989-01-01

    An example of positive outcome of proper attitude of the media and public on the occasion of shipping of nuclear fuel is described. Nothing new was invented in the way of public relations issue management. But a combination of a number of proven techniques were put together and the public relations plan that was highly successful. early planning was of great help. Public officials were well informd by means of ANS organized seminars. ANS had experts from Sandia Labs (a major government research facility), General Electric (the cask supplier), the railroad we planned to use and Northern States Power Company on the program to describe what was going to happen and why it was safe. These sessions are believed to head off a major portion of the local opposition. A cooperation was established with the states of Wisconsin and Minnesota in providing shipment-specific training for emergency response personnel along the route. Safety, obviously, was the number one concern expressed by public officials. Knowing that would be the case, it was decided to provide some optional extras to go with the shipments. There was a consultant yo do a safety analysis of all the possible rail routes between the plant and storage facility. Though none was required by law, a shipment-specific emergency response plan which was prepared. Another important effort which was maintained from the beginning was sharing information among the participants. In dealing with the news media, an attemp was made to stick to a single source of information as much as possible. When dealing with the news media, one should refuse to apologize for modern technology. One should attack, at every opportunity, the idea that a r isk-freesociety is worth the price of returning to the Dark Ages. The contributions of nuclear technology are numerous and far-reaching. Its negative impacts on health and safety have been minor compared with most other major industrial technologies. Certainly there is risk in stepping out of

  4. Angiogenesis dysregulation in term asphyxiated newborns treated with hypothermia.

    Directory of Open Access Journals (Sweden)

    Henna Shaikh

    Full Text Available Neonatal encephalopathy following birth asphyxia is a major predictor of long-term neurological impairment. Therapeutic hypothermia is currently the standard of care to prevent brain injury in asphyxiated newborns but is not protective in all cases. More robust and versatile treatment options are needed. Angiogenesis is a demonstrated therapeutic target in adult stroke. However, no systematic study examines the expression of angiogenesis-related markers following birth asphyxia in human newborns.This study aimed to evaluate the expression of angiogenesis-related protein markers in asphyxiated newborns developing and not developing brain injury compared to healthy control newborns.Twelve asphyxiated newborns treated with hypothermia were prospectively enrolled; six developed eventual brain injury and six did not. Four healthy control newborns were also included. We used Rules-Based Medicine multi-analyte profiling and protein array technologies to study the plasma concentration of 49 angiogenesis-related proteins. Mean protein concentrations were compared between each group of newborns.Compared to healthy newborns, asphyxiated newborns not developing brain injury showed up-regulation of pro-angiogenic proteins, including fatty acid binding protein-4, glucose-6-phosphate isomerase, neuropilin-1, and receptor tyrosine-protein kinase erbB-3; this up-regulation was not evident in asphyxiated newborns eventually developing brain injury. Also, asphyxiated newborns developing brain injury showed a decreased expression of anti-angiogenic proteins, including insulin-growth factor binding proteins -1, -4, and -6, compared to healthy newborns.These findings suggest that angiogenesis pathways are dysregulated following birth asphyxia and are putatively involved in brain injury pathology and recovery.

  5. The Role of Government Public Relations As Facilitators Communication in Bureau of Public Relation at South Kalimantan Province

    Directory of Open Access Journals (Sweden)

    Belinda Devi Larasati Siswanto

    2016-07-01

    Full Text Available As the windows of information, communication facilitator role in Government Public Relation (GPR serve as all-in-and-out of information from or to publics. For that, this research be held to find about the communication facilitator role on GPR of South Kalimantan Provincial Government. This research intends to knowing communication facilitator role to provide information to people and otherwise. This research uses qualitative approach with descriptive case study method, the data collection through observation and depth interview with informants purposively selection. The research result showing the communication facilitator role in GPR Bureau is not optimal, caused by unavailable information who can be accessed by the public or the otherwise. Government Information which should can be accessed at government official website or at the social media not be optimized by the GPR Bureau well as the Main Information Management and Documentation Officer (IMDO whose role is held by the GPR Bureau of the information that should be accessible through the website, is not available. This contrasts with some Local Work Unit function only a Subsidiary IMDO, but they were ready to provide information to the public through a website managed

  6. The rule on granting subsidies for public relations

    International Nuclear Information System (INIS)

    1978-01-01

    These provisions are established on the basis of and to enforce the ''Law for the proper execution of the budget concerning subsidies'' and the Enforcement Ordinance for the ''Law for the proper execution of the budget concerning subsidies''. The Regulation covers the subsidies for the expenses for spreading the knowledge concerning nuclear power generation to the inhabitants in the surrounding areas of such nuclear power generating facilities, for the expenses for establishing the facilities for such popularization, and the office expenses for preparing the improvement plans on the surrounding areas of power generating facilities. Terms are explained, such as nuclear power generating facilities, the facilities related to nuclear power generation, nuclear power generating facilities, etc. and establishments. The subsidies for public relations are delivered to the prefectures where nuclear power generating facilities, etc. have been installed or are planned to be set up, and the subsidies for preparing the improvement plans are granted to the prefectures where the prescribed surrounding areas are involved. The subsidy for public relations delivered to one establishment is limited to 10 million yen in each fiscal year. Applications for the delivery of subsidies shall be filed to the directors of competent authorities-the Director General of the Science and Technology Agency or the Minister of International Trade and Industry. (Okada, K.)

  7. Promotion of public awareness relating nuclear power in young generation

    International Nuclear Information System (INIS)

    Kobayashi, Yoko

    2011-01-01

    Although nuclear power presents problems of waste, safety and non-proliferation, many people understand that it is an essential energy for addressing the global climate and reducing CO2. However, a vague negative-image to the radiation and nuclear power is deep-rooted among the public. Young generation is not an exception. It is very important to transfer many information from the experienced generation in the industry to young generations. In this paper, the research that applied the information intelligence to nuclear power, which involves of the nuclear fuel cycle, and the communication related activities for the social acceptance and improvement. (author)

  8. Marketing and public relations in the emergency department.

    Science.gov (United States)

    Mayer, T A; Tilson, W; Hemingway, J

    1987-02-01

    This article outlines the elements of successful ED marketing, as well as providing definitions for terms used within the marketing process. In today's competition and rapidly changing environment, marketing and public relations are tools that every ED Medical Director may want to consider. Because the marketing process requires a great deal of time and effort, as well as a high degree of intellectual honesty, it should never be entered into without a strong commitment. However, marketing the ED can be among the most productive, stimulating, and gratifying experiences for the ED Medical Director, the emergency department physicians, and all ED service personnel.

  9. The importance planning of public relations in tourist organizations’ communication

    Directory of Open Access Journals (Sweden)

    Maria Carmenl IORDACHE

    2009-12-01

    Full Text Available Accomplishing efficient communication on tourist markets means efficiently developing and operating a communication system, that is designing and implementing an adequate structure of communication activities. Tourist organizations must have a communication strategy according to communication activities’ target, global objectives pursued, communication targets aimed, communication media used and contents of transmitted messages and, last but not least, resources allocated to implement communicational procedures. In order to attract consumers on a highly competitive market, there are several management-marketing instruments of which some are public relations whose role is to create a positive image of a tourist organization and, implicitly, of its products and services.

  10. Models of political public relations: Testing the situation in Catalonia

    Directory of Open Access Journals (Sweden)

    Dr. Jordi Xifra Triadú

    2008-01-01

    Full Text Available The idea that political communication strategies are an application of marketing strategies to political field is today commonly shared by specialists. For them public relations is viewed like a set of techniques that serves political parties and other actors of the political scene, concentrated on media relations. This instrumental perspective is not in keeping with structural dimension of public relations in political activity and communication of his actors: political parties, pressure groups and political leaders. In this point of view, during managing periods of governance or opposition and during electoral campaigns, the most applied communication form by political parties is structured in accordance with the major public relations models: press agent model, public information model, two way asymmetrical model, and two way symmetrical model. This research prove hypothesis in Catalonia according the results of a quantitative survey focused on inside professionals who provide services for the seven main political parties in this Spanish Autonomous Community.RESUMEN:La idea de que las estrategias de comunicación política constituyen una aplicación de las estrategias del marketing al ámbito político es hoy comúnmente compartida por los analistas. Para éstos, las relaciones públicas son percibidas como un conjunto de técnicas al servicio de los partidos políticos y de otros actores de la escena política concentradas en las relaciones con la prensa. Esta perspectiva instrumental no concuerda con la dimensión estructural de las relaciones públicas en la actividad política y comunicativa de sus actores: partidos políticos, grupos de presión y líderes. Desde este punto de vista, tanto en los periodos de gestión u oposición como en los electorales, la forma comunicativa más aplicada por los partidos políticos se estructura de acuerdo con los modelos tradicionales de las relaciones públicas: agente de prensa, información p

  11. Public relation aspects of site selection in the United Kingdom

    International Nuclear Information System (INIS)

    Curtin, T.

    1996-01-01

    Following a recent review, the UK Government has confirmed that it continues to favour a policy of deep disposal of intermediate low-level waste. The Government's continuing policy stems from the recommendations of the 1976 Royal Commission on Environmental Pollution (the 'Flowers'Report) and White Papers issued in 1977 and 1982 and 1982. The paper outlines the search for a disposal site in the UK. Nirex (Nuclear Industry Radioactive Waste Executive) was set up in 1982 to research and develop disposal facilities for intermediate low-level waste and low-level waste. At that time disposal facilities were envisaged as an engineered near-surface facility for LLW and short-lived ILW, and a modified mine or purpose built cavity at greater depth for long-lived ILW. Investigation of various sites followed and is discussed in the paper. The paper reviews the lessons learned in the field of public relations and public consultation, notably that public acceptance is a key factor in site selection and development, and that transparency is essential. For example, when it was announced that Sellafield was the preferred site for the repository, local councils became involved in discussions and planning, and Nirex is becoming more and more integrated into the local community. (author)

  12. Public Diplomacy and Refugee Relations Reflections of Turkey’s Refugees Relations on the International Media

    Directory of Open Access Journals (Sweden)

    Ergün Köksoy

    2015-11-01

    Full Text Available Public diplomacy is described as a new form of relations and communications between countries and societies in the field of international relations with the process of globalisation. The subject of refugees shown among the priority issues can be solved through international cooperation and solidarity with its results affecting all countries and societies, that’s why becoming part of public diplomacy. Asylum seekers and refugee rights are guaranteed by the Universal Declaration of Human Rights and considered to be an area that the international community needs to take the roles and share responsibilities. In this aspect, it is shown as global responsibilities and part of the humanitarian sensibility of countries and societies. In one hand, asylum seekers and refugees are considered to be the subject of the problem and crisis, on the other hand, due to contributing to the human and cultural interaction between the different communities, these are specified as part of public diplomacy. This article discusses the relationship between public diplomacy and refugees relations which provides the interaction between countries and effects the prestige and perception of them. In the study, to reveal the reflections of Turkey’s Refugees Relations on the International Media, three highest-circulation newspapers (“The Guardian”, “Le Monde”, “Der Spiegel” will be choosen from three important EU countries (United Kingdom, France, Germany. These newspapers’ headlines and news content which related to Turkey and Syrian refugees are going to be analized on three-month period. As a result, Turkish public diplomacy and refugee relations and its implications on the international media in the context of Syrian refugees will be evaluated and some recommendations for the future of Turkish public diplomacy and refugee relations will be provided.

  13. Monitoring angiogenesis using magnetic resonance methods

    DEFF Research Database (Denmark)

    Peters, David Alberg

    2008-01-01

    and the involved signaling molecules. Subsequently, a short review of contrast agents and perfusion measurements is given. Finally, methods for monitoring angiogenesis using magnetic resonance imaging are reviewed. A method for monitoring early stages of angiogenesis as well as the effect of anti...

  14. Blockade of Tumor Necrosis Factor-Alpha: A Role for Adalimumab in Neovascular Age-Related Macular Degeneration Refractory to Anti-Angiogenesis Therapy

    Directory of Open Access Journals (Sweden)

    Beatriz Fernández-Vega

    2016-03-01

    Full Text Available Aims: To report a case of wet age-related macular degeneration (wet-AMD refractory to intravitreal anti-vascular endothelial growth factor (anti-VEGF therapy in a patient who showed visual and anatomical improvement and stabilization after starting a subcutaneous treatment course with adalimumab, an anti-tumor necrosis factor-alpha (TNF-α drug, for concomitant Crohn's disease. Methods: Observational case report of a female patient. Ophthalmological evaluation was performed by slit lamp and ophthalmoscopy (posterior pole and anterior segment. Best-corrected visual acuity (BCVA was determined, and imaging was performed by fluorescein angiography, indocyanine green angiography, and optical coherence tomography (OCT. Intravitreal therapies used and treatment with anti-TNF-α were recorded. Results: A 64-year-old woman with wet-AMD was treated with fourteen intravitreal injections of ranibizumab (0.5 mg for a period of 40 months with intervals of 1-6 months. She initially showed a good visual and anatomical response to periodic anti-VEGF treatment but during check visits, anatomical and functional responses deteriorated. At the 40-month follow-up, the patient had developed Crohn's disease, and her rheumatologist started treatment with adalimumab (40 mg subcutaneously every 2 weeks. During the 25 months of treatment with adalimumab, the patient did not require any additional intravitreal anti-VEGF treatments because her BCVA, clinical, and OCT findings improved and remained stable. Conclusions: We described a case of a patient with wet-AMD refractory to anti-VEGF therapy, which clinically benefited from subcutaneous adalimumab therapy. Treatment with subcutaneous anti-TNF-α in combination with anti-VEGF therapy avoids the high cost and risks related to multiple intravitreal anti-VEGF injections with good functional and anatomic outcomes.

  15. 48 CFR 31.205-1 - Public relations and advertising costs.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Public relations and... Organizations 31.205-1 Public relations and advertising costs. (a) Public relations means all functions and...; or (2) Maintaining or promoting reciprocal understanding and favorable relations with the public at...

  16. Differences in Ethical Standards: Factoring in the Cultural Expectation in Public Relations Education.

    Science.gov (United States)

    Neff, Bonita Dostal

    Focusing on ethics in public relations from a multicultural point of view brings together elements which are critical to international public relations. The Public Relations-Ethics-Multicultural (PREM) model illustrates that articles can be found in the literature on ethics, public relations, and multicultural as individual concepts. The…

  17. [Markers of angiogenesis in tumor growth].

    Science.gov (United States)

    Nefedova, N A; Kharlova, O A; Danilova, N V; Malkov, P G; Gaifullin, N M

    2016-01-01

    Angiogenesis is a process of new blood vessels formation. The role of angiogenesis in growth, invasion and metastasis of malignant tumours is nowdays universally recognized. Though, investigation of mechanisms of blood vessels formation and elaboration methods for assessment of tumour angiogenesis are still up-dated. Another important concern are different aspects of usage of immunohistochemical markers of blood vessels endothelium (CD31 and CD34) for assessment of tumour aggressiveness and prognosis. The problems of malignant lymphangiogenesis are also up-to-date. The focus is on methods of immunohistochemical visualization of forming lymphatic vessels, role of podoplanin, the most reliable marker of lymphatic vessels, in their identification, and formulization of the main criteria for lymphangiogenesis estimation, its correlation with metastatic activity and prognostic potential. Studying of angiogenesis and lymph angiogenesis in malignant tumors is important and challenging direction for researching tumour progression and invention of antiangiogenic therapy.

  18. CONCEPTUAL AND ACCOUNTING ASPECTS RELATING CONSTRUCTION CONTRACTS IN PUBLIC ENTITIES

    Directory of Open Access Journals (Sweden)

    Ţenovici Cristina Otilia

    2013-04-01

    Full Text Available Subsequent to the nature of activities performed in construction contracts, the date on which contract execution begins and the date of its completion generate two major issues in accountancy. The former issue occurs as a result of the fact that most construction contracts concluded by public sector entities do not specify the value of revenues under the contracts and accountancy therefore must find solutions for the way to allocate contract costs for the reporting periods of time when work was rendered and related expenses were recognized. The latter issue occurs when construction contracts were concluded on a commercial or non-commercial basis while recuperating partial or total costs, an issue which accounting has to settle in relation with the allocation of contract revenues and contract costs of reporting periods during which work was performed.

  19. Public Relations dan Masyarakat dalam Memacu Pertumbuhan Pariwisata

    Directory of Open Access Journals (Sweden)

    Yuanita Safitri

    2015-04-01

    Full Text Available Tourism is an important determinant for a region’s economic growth—the higher income from tourism, the higher its gross regional domestic product. To be successful in exposing potential tourism sites, a region does not only depend on the beauty of the nature but also how to access the sites, on-site accommodation and the mutual relationship between local government and local community.The fact is many regions have difficulties in developing mutual relationship between local government and local community. It means what most important is how the tourism industry is being managed. One most important aspect of managing the tourism industry is the cooperation and communication between the local community and the government. This article aims to discuss how public relations and the local community work to stimulate tourism growth in a synergy. Using descriptive qualitative method, this article recommends a model of communication strategy—in which the local community serves mainly as the tourism’s public relation agents, and also serves as a reference method in evaluating a local government’s communication strategies in regional tourism industry. 

  20. Media Sosial dan Peran Manajerial Public Relations PT PLN Persero

    Directory of Open Access Journals (Sweden)

    Narayana Mahendra Prastya

    2013-12-01

    Full Text Available Abstract: Social media affect communication technicians and managerial roles in Public Relations (PR. This study observes PR managerial role in PT PLN Persero in the policy making of social media use for the company’s internal environment. This research use interviews, document studies, and observation as data collection techniques. The results show that the role of communicating the policy is more dominant than the managerial role. Factors influencing PR managerial role are organization’s recognition on the PR role and function in the organization, the number of personnel in the PR department, and the authority overlap within the organization.   Abstrak: Media sosial memengaruhi praktek Public Relations (PR sebagai teknisi komunikasi dan manajerial. Penelitian ini membahas peran manajerial PR d PT PLN Persero dalam penyusunan kebijakan penggunaan media sosial untuk lingkungan internal perusahaan. Penelitian menggunakan metode kualitatif dengan teknik pengumpulan data wawancara, studi dokumen, dan observasi. Hasil penelitian menunjukkan bahwa Bidang Komunikasi Korporat PT PLN Persero sudah melaksanakan peran manajerial walaupun masih didominasi peran mengomunikasikan kebijakan. Peran manajerial PR dipengaruhi oleh pemahaman dan pengakuan formal organisasi terhadap peran dan fungsi PR dalam organisasi, jumlah personel di departemen PR, dan tumpang tindih kewenangan dengan bidang kerja lain dalam organisasi.

  1. PUBLIC RELATION BASED MODEL OF INTEGRATED MARKETING COMMUNICATIONS

    Directory of Open Access Journals (Sweden)

    Ljupka Naumovska

    2016-12-01

    Full Text Available The marketing communications industry and theory are facing rapid changes in accordance with global business and society fluctuations. Global and local market conditions are constantly varying and thus creating hardly predictable environment. The most implemented tool for marketing communications – advertising, is losing its power for effective communications; customers are becoming over-advertised and resistant to traditional advertising stimuli. Advertising, as one-way communication mass media tool is no longer effective as previously, hence can no longer fulfill the role of leading marketing mix tool. Therefore, the necessity for altering the structure of the traditional marketing communication mix elements, emphasizing the role of other elements but advertising, with more personalized and interactive functions. One method for improvement of marketing communication’s mix efficiency is by reallocation the leading role of advertising with public relations. The practice of public relations tools can ensure higher level of transparency in internal and external organizational communications and thus can certify more effective marketing communication. The theoretical research is supported with qualitative research of business segment by conducting a detailed interview for the marketing communication practice.

  2. MANAJEMEN PUBLIC RELATIONS PENDIDIKAN ISLAM (Kajian Tematik Al Qur’an dan Al Hadits

    Directory of Open Access Journals (Sweden)

    Dian Iskandar Jaelani

    2014-11-01

    Full Text Available Public Relations (PR has two senses. First, in terms of public relations as communication techniques. And second, public relations as a method of communication. The concept of Public Relations with respect to understanding through knowledge creation activities, and through these activities that impact the changes will appear. Public Relations itself is a combination of various immunization and included in the ranks of the social sciences such as political science, economics, history, psychology, sociology, communication and others.

  3. THE INFLUENCE OF MARKETING PUBLIC RELATION AND SERVICE QUALITY ON CORPORATE IMAGE THROUGH PUBLIC OPINION: STUDIES AT MANDIRI BANK

    Directory of Open Access Journals (Sweden)

    Vera Suciyati

    2015-09-01

    Full Text Available This research aims to analyze the influence of marketing public relation and service quality at Bank Mandiri on corporate image through public. Convenience sampling method has been selected in order to obtain the data in this study. The analysis method that used was the path analysis. The research result had shown that: marketing public relation and service quality have significant influence simultaneously and partially on public opinion on the first structure equation. The second structure equation shows that: marketing public relation, service quality had significant influence simultaneously on corporate image. The service quality have not partially the quality of service have not influence significant partially on corporate, but variable marketing and public relation have  partially influential public opinion influence significant partially on corporate image.DOI: 10.15408/etk.v12i2.1916

  4. Focus on Ethics and Public Relations Practice in a University Classroom

    Science.gov (United States)

    Smudde, Peter M.

    2011-01-01

    Public relations action relies on sound decision making about how to inspire cooperation between an organization and its publics. Such thinking must uphold principles for ethical communication. Effectively combining ethics with public relations practice for students is key. A pedagogical approach to public relations ethics, hinging on selected…

  5. Is using social media "good" for the public relations profession? A critical reflection

    DEFF Research Database (Denmark)

    Valentini, Chiara

    2015-01-01

    Scholarship in public relations seems to be overly positive about social media. The dominant discourse in public relations is that using social media is “good”, because social media can help organizations in developing dialogs and relationships with publics and in engaging with them. Yet empirical...... evidence in public relations is mostly case-dependent and limited to the realm of understanding current organizational practices, with limited understanding of the concrete value for organizations or for publics. In this paper I question the utility of social media for publics, organizations and public...... relations, and I argue that the positive view of social media held by the majority of public relations scholars is grounded on the profession’s need to reconcile the two sides of public relations identity—the rhetorical and the relational. A discussion of whether current public relations practices in social...

  6. Regulation for delivery of subsidies for public relations and safety

    International Nuclear Information System (INIS)

    1985-01-01

    The regulations provide for subsidies for the public relations activities and safety operations carried out by a local government for the local inhabitants in the vicinity of a nuclear power generation, etc. facility. This type of activity includes the dissemination of information on nuclear power, studies on securing the safety of the inhabitants and communication concerning the facility safety. The contents are as follows : limits of the subsidies, terms of subsidy allocations, the application for subsidies, determination of subsidy allocations, withdrawal of applications, the conditions to the allocations, a report on the work proceedings, a report on the results, confirmation on the sum of subsidies, withdrawal of the decision for subsidies, limitations for disposal of the properties, etc. (Kubozono, M.)

  7. Regulation for delivery of subsidies for public relations and safety

    International Nuclear Information System (INIS)

    1981-01-01

    This rule is established under the provisions of the law for the proper enforcement of subsidy budgets and the ordinance for the execution of this law, and to practice these provisions. It is applied to subsidies for the expenses of popularizing the knowledge of atomic power generation to inhabitants in the surrounding areas of atomic power generating facilities, investigation on the security of inhabitants in these areas, communication and coordination concerning the safety of such facilities during and after their installation and other expenses of establishing the facilities for public relations to inhabitants in the surrounding areas of these facilities. Basic terms are defined, such as atomic power generating facility, facility related to atomic power generation, and place of business. Subsidies are delivered to prefectures, cities, towns and villages where atomic power generating facilities are or are expected to be set up, prefectures including cities, towns and villages adjacent to those where such facilities are or are expected to be established, and prefectures which include the surrounding areas of those facilities. The limits of subsidies are stipulated in the lists attached. The terms of delivery vary according to the kinds of atomic power generating facilities and related facilities. Prefectures or cities, towns and villages which intend to apply for the delivery of subsidies shall file specified applications attached with the explanation of subsidy business outlines to the director of the ministry or agency concerned. Decision and conditions of delivery, reports on the situations and results of business and other concerned matters are defined, respectively. (Okada, K.)

  8. Retracted or Withdrawn Publications in Journals Relating to Plastic Surgery.

    Science.gov (United States)

    Hwang, Kun; Wu, XiaJing

    2018-02-23

    The aim of this study was to determine how many papers have been retracted or withdrawn, and for what reason, in journals relating to plastic surgery.PubMed and SCOPUS were used, with the search terms (retracted OR withdrawn) AND (article OR publication OR paper) AND {(plastic surgery) OR (cosmetic surgery) OR (maxillofacial surgery) OR (craniofacial surgery)}. The papers were analyzed and classified according to the reason for retraction or withdrawal, journal name, publication year, and author. In the PubMed and SCOPUS, 227 and 114 titles were found, respectively, from which 34 duplicate titles were removed. An additional 261 titles which did not include "retracted" or "withdrawn" were removed, leaving 46 papers and 6 mined papers were added. The 52 full texts (42 "retracted" and 10 "withdrawn") were analyzed.The most frequent reason for retraction or withdrawal was duplication (17, 32.7%) followed by the author's request (9, 17.3%), plagiarism (7, 13.5%), and lack of permission (5, 9.6%). Retraction was most common in Plast Reconstr Surg (6, 12%) followed by Aesthetic Plast Surg (4, 7.9%), Ann Plast Surg (2, 3.9%), J Plast Reconstr Aesthet Surg (2, 3.9%), and Surg Res (2, 3.9%). Most authors retracted a paper just once; however, 6 authors retracted a paper twice or more. The first retraction was found in 1991, and the number of retractions showed a tendency to increase over time. However, the duplication rate did not change over time (R = 0.178, P = 0.117).Journal reviewers, as well as production editors, should check for duplication, plagiarism, or permission-related problems.

  9. Persepsi Mahasiswa tentang Posisi Strategis Profesi Public Relations

    Directory of Open Access Journals (Sweden)

    Trie Damayanti

    2013-06-01

    Full Text Available Penelitian berjudul Persepsi Mahasiswa Tentang Posisi Strategis Profesi Public Relations ini bertujuan untuk mengetahui (a Bagaimana mahasiswa Jurusan Humas memaknai posisi strategis Profesi PR dalam organisasinya, (b Bagaimana mahasiswa Jurusan Humas memandang dan memaknai Ilmu Kehumasan yang dimiliki untuk diterapkan pada Profesi PR, (c Bagaimana mahasiswa Jurusan Humas memandang dan memaknai kemampuan yang harus dimiliki oleh seorang PRO. Penelitian ini menggunakan metode kualitatif dengan pendekatan fenomenologis, dengan perspektif teoretis konstruksi sosial atas realitas.Nara sumber diambil dari mahasiswa Jurusan Humas semester III, V, dan VII sebanyak enam orang. Penentuan sampel dilakukan secara purposif. Hasil penelitian menun- jukkan bahwa (1 mahasiswa memaknai posisi strategis PR dilihat dari kedekatannya dengan pengambil kebijakan seperti realitas yang memang beredar di masyarakat bahwa semakin dekat seseorang dengan pimpinan akan semakin strategis posisi tersebut; (2 mahasiswa memandang dan memaknai  Ilmu Kehumasan yang dimiliki sesuai dengan materi perkuliahan yang pernah didapat dan realitas yang berkembang di masyarakat tentang profesi ke-PRan. Ilmu Kehumasan lebih dilihat dari materi yang membutuhkan skill dan materi yang aplikatif; (3 mahasiswa memandang dan memaknai kemampuan yang harus dimiliki pada hal yang berkaitan dengan materi perkuliahan ditambah dengan bahasa asing, dan komputer seperti halnya realitas yang memandang kemampuan komputer dan penguasaan bahasa asing menjadi hal yang membuat orang dipandang lebih kompeten dibandingkan yang lain. Kesimpulan didapat bahwa pandangan mahasiswa terhadap posisi strategis Ilmu Kehumasan yang akan diterapkan, sampai dengan kemampuan yang harus dimiliki oleh seorang PRO sangat dipengaruhi oleh realitas dan pengetahuan sebelumnya pada pemahaman tentang strategi, pemaknaan pada Ilmu Kehumasan juga dipengaruhi pada pengalaman mereka pada Ilmu Kehumasan dan pengetahuan yang berkembang

  10. Mechanical and Chemical Signaling in Angiogenesis

    CERN Document Server

    2013-01-01

    This volume of Studies in Mechanobiology, Tissue Engineering and Biomaterials describes the most recent advances in angiogenesis research at all biological length scales: molecular, cellular and tissue, in both in vivo and in vitro settings.  Angiogenesis experts from diverse fields including engineering, cell and developmental biology, and chemistry have contributed chapters which focus on the mechanical and chemical signals which affect and promote blood vessel growth. Specific emphasis is given to novel methodologies and biomaterials that have been developed and applied to angiogenesis research. 

  11. The rule on granting subsidies for public relations

    International Nuclear Information System (INIS)

    1979-01-01

    The rule is defined under the law concerning subsidies and the provisions of the order for execution of the law. Basic terms are explained, such as: nuclear power generating facilities; related facilities of nuclear power generation; nuclear power generating facilities, etc.; and place of enterprise. Subsidies are granted by the head of the authorities concerned (the Director General of Science and Technology Agency or the Minister of International Trade and Industry) to popularize knowledge of nuclear power generation to inhabitants in surrounding areas of the facilities, or to support expenses of the preparation of arrangement programs, etc. Subsidies for public relations are delivered to those prefectures where nuclear power generating facilities, etc. are or are expected to be established, and subsidies for arrangement programs to those where the surrounding areas are included. Limits of the subsidies to a prefecture range from 6 million yen to 18 million yen for each fiscal year according to specified terms of the facilities concerned. Limits of subsidies for arrangement programs to place of enterprise extend from 500,000 yen to 1 million yen. Prefectures shall file an application for subsidies to the head of the authorities concerned with gists of business according to the forms attached. Receiving the application, the head shall examine it and notify to the applicant the decision of delivery and its conditions without delay in writing, when such settlement is made. Terms and conditions of delivery, payment of subsidies and others are stipulated respectively. (Okada, K.)

  12. Cancer gene therapy targeting angiogenesis: An updated Review

    Science.gov (United States)

    Liu, Ching-Chiu; Shen, Zan; Kung, Hsiang-Fu; Lin, Marie CM

    2006-01-01

    Since the relationship between angiogenesis and tumor growth was established by Folkman in 1971, scientists have made efforts exploring the possibilities in treating cancer by targeting angiogenesis. Inhibition of angiogenesis growth factors and administration of angiogenesis inhibitors are the basics of anti-angiogenesis therapy. Transfer of anti-angiogenesis genes has received attention recently not only because of the advancement of recombinant vectors, but also because of the localized and sustained expression of therapeutic gene product inside the tumor after gene transfer. This review provides the up-to-date information about the strategies and the vectors studied in the field of anti-angiogenesis cancer gene therapy. PMID:17109514

  13. Angiogenesis and Cancer Prevention by Selenium

    National Research Council Canada - National Science Library

    Lu, Junxuan

    2002-01-01

    ...) in breast cancer chemoprevention. We first established the anti- angiogenesis phenomenon of chemopreventive intake of Se with data supporting an association of reduced microvessel density and decreased vascular endothelial growth...

  14. Therapeutic Angiogenesis for Treating Cardiovascular Diseases

    Science.gov (United States)

    Deveza, Lorenzo; Choi, Jeffrey; Yang, Fan

    2012-01-01

    Cardiovascular disease is the leading cause of death worldwide and is often associated with partial or full occlusion of the blood vessel network in the affected organs. Restoring blood supply is critical for the successful treatment of cardiovascular diseases. Therapeutic angiogenesis provides a valuable tool for treating cardiovascular diseases by stimulating the growth of new blood vessels from pre-existing vessels. In this review, we discuss strategies developed for therapeutic angiogenesis using single or combinations of biological signals, cells and polymeric biomaterials. Compared to direct delivery of growth factors or cells alone, polymeric biomaterials provide a three-dimensional drug-releasing depot that is capable of facilitating temporally and spatially controlled release. Biomimetic signals can also be incorporated into polymeric scaffolds to allow environmentally-responsive or cell-triggered release of biological signals for targeted angiogenesis. Recent progress in exploiting genetically engineered stem cells and endogenous cell homing mechanisms for therapeutic angiogenesis is also discussed. PMID:22916079

  15. NADPH Oxidases, Angiogenesis, and Peripheral Artery Disease

    Directory of Open Access Journals (Sweden)

    Pradeep Manuneedhi Cholan

    2017-07-01

    Full Text Available Peripheral artery disease (PAD is caused by narrowing of arteries in the limbs, normally occurring in the lower extremities, with severe cases resulting in amputation of the foot or leg. A potential approach for treatment is to stimulate the formation of new blood vessels to restore blood flow to limb tissues. This is a process called angiogenesis and involves the proliferation, migration, and differentiation of endothelial cells. Angiogenesis can be stimulated by reactive oxygen species (ROS, with NADPH oxidases (NOX being a major source of ROS in endothelial cells. This review summarizes the recent evidence implicating NOX isoforms in their ability to regulate angiogenesis in vascular endothelial cells in vitro, and in PAD in vivo. Increasing our understanding of the involvement of the NOX isoforms in promoting therapeutic angiogenesis may lead to new treatment options to slow or reverse PAD.

  16. Excessive angiogenesis associated with psoriasis as a cause for cardiovascular ischaemia.

    Science.gov (United States)

    Malecic, Nina; Young, Helen S

    2017-04-01

    Psoriasis, a common disease affecting 2%-3% of the UK population, produces significant impairment of quality of life and is an immense burden on sufferers and their families. Psoriasis is associated with significant cardiovascular comorbidity and the metabolic syndrome. Angiogenesis, a relatively under-researched component of psoriasis, is a key factor in pathogenesis of psoriasis and also contributes to the development of atherosclerosis. Vascular endothelial growth factor (VEGF) is a well-established mediator of pathological angiogenesis which is upregulated in psoriasis. It is possible that, in patients with psoriasis, cutaneous angiogenesis may be both a marker for systemic vascular pathology and a novel therapeutic target. In this viewpoint study, the role of VEGF-mediated angiogenesis as a cause for cardiovascular events in patients with psoriasis is explored. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  17. Public Knowledge about Hepatitis B-Related Issues in Korea

    Directory of Open Access Journals (Sweden)

    C Chrusch

    1996-01-01

    Full Text Available Hepatitis B infection is endemic in many parts of the world, including Korea. Basic knowledge of the hepatitis B virus by the public is a prerequisite for the development of a successful vaccination program. A survey was conducted in rural Korea to examine public knowledge of hepatitis B etiology, symptoms, transmission, risk factors and prevention. It was found that knowledge independently correlated with education and female sex, but that overall knowledge of hepatitis B was poor. The preferred information sources in order of preference were physicians, television and public health nurses. This information may be useful in designing public health education and vaccination programs in developing populations.

  18. Clinical implications of angiogenesis in cancers

    Directory of Open Access Journals (Sweden)

    Roberta WC Pang

    2006-06-01

    Full Text Available Roberta WC Pang1, Ronnie TP Poon2 Departments of 1Medicine and 2Surgery, The University of Hong Kong, Pokfulam, Hong Kong, ChinaAbstract: Angiogenesis plays an important role in the growth and progression of cancer. The regulation of tumor angiogenesis depends on a net balance of angiogenic factors and antiangiogenic factors, which are secreted by both tumor cells and host-infiltrating cells. Numerous studies have indicated that assessment of angiogenic activity by either microvessel density or expression of angiogenic factors in cancer can provide prognostic information independent of conventional clinicopathological factors such as tumor staging. Some studies also suggested that assessment of tumor angiogenesis may predict cancer response to chemotherapy or radiotherapy. However, the most important clinical implication of tumor angiogenesis is the development of a novel strategy of anticancer therapy targeting tumor vessels instead of cancer cells. Antiangiogenic therapy aims to inhibit the growth of tumor, and current evidence suggests that it works best in combination with conventional cytotoxic chemotherapy. Recently, a monoclonal antibody against vascular endothelial growth factor, which is one of the most potent angiogenic factors, has been approved for clinical use in colorectal cancer patients after a clinical trial confirmed that combining the antibody with standard chemotherapy regimen could prolong patient survival. The clinical implications of angiogenesis in cancer are reviewed in this article.Keywords: angiogenesis, antiangiogenic therapy, cancer, prognosis

  19. Strategy of public relations in the system of management of organization

    OpenAIRE

    Tereschenko, D.

    2010-01-01

    The question of links of the strategic planning of public relations and a system approach to management of organization activity have been researched. The maintenance of stages of strategic plan of public relations in the organization's management system is opened.

  20. Issues related to public perception of radioactive waste management options

    International Nuclear Information System (INIS)

    Taylor, D.M.

    2007-01-01

    Public perceptions about radioactive waste are generally rather or even strongly negative. They are also very poorly informed. This is rather unfortunate as it is these perceptions that appear to greatly influence the Public views on nuclear energy in general. This, in turn, has had an influence on political decisions. On the other hand, in a very clear majority of the Member States of the European Union, the Public have already indicated that they would be ready to accept the important role of nuclear in their future energy mix as long as all the radioactive wastes can be safely managed. However perceptions about nuclear energy and radioactive waste should be seen in the context of the Public wider perceptions on energy and, in particular, the role in the future of different sources. It may be wrong for political decisions on nuclear energy in the future to rely to heavily on the Public perceptions. (author)

  1. The Public Employment Relations Law. What Every Board Member Should Know Series Volume 6.

    Science.gov (United States)

    Taylor, Bruce; And Others

    This booklet is designed to help school board members understand New Jersey's public employee relations law and to serve as a useful guide to the operations of the New Jersey Public Employment Relations Commission. Individual chapters focus in turn on the Public Employment Relations Commission, unfair labor practices, the scope of collective…

  2. The Role of Public Relations as A Management Function in Higher Education

    Directory of Open Access Journals (Sweden)

    Anggreni Putri

    2018-01-01

    Full Text Available Nowadays, public relations in higher education institution become an integral part of the management team. It must contribute to achieve organizational goals and demonstrate an organizational accountability identified by measurable result. Placement public relations at certain positions in management has consequences in the process of implementation of the public relations function. It happened because the management, workflow and hierarchy greatly affects work patterns as well as patterns of decision making in carrying out communication tasks performed by public relations.The goal of research to find out the role and position in public relations in management education institution (university in achieving its objectives. After identification of roles and positions performance public relations firm, the study aims to evaluate the performance of public relations as part of management.This study used a qualitative descriptive research method with the study subjects were Mahendradatta University Public Relations and internal stakeholders. Data drawn from interviews with the help of the interview guide and then processed into information that can answer the research objectives.The result of the research shows that not all public relations officers in Mahendradatta University, do their role as real public relations officers. They also do not have the same understanding about the role of a public relations officer will just place public relations in same position as marketing.

  3. At the Fundraising Core: Strategic Public Relations in Fundraising Practice. CASE White Paper

    Science.gov (United States)

    Satchwell, Carol M.

    2010-01-01

    This white paper reports on a study exploring the views of chief fundraising executives at private colleges and universities about the relationship between public relations and fundraising. The research focused on how fundraising executives define public relations and use public relations tactics and strategies within their institutions'…

  4. Missing Citations, Bulking Biographies, and Unethical Collaboration: Types of Cheating among Public Relations Majors

    Science.gov (United States)

    Auger, Giselle A.

    2013-01-01

    Students cheat. For the field of public relations, which continually struggles for credibility, the issue of student cheating should be paramount, as the unethical students of today become tomorrow's practitioners. Through a survey of 170 public relations majors, this study examined the importance students place on the Public Relations Society of…

  5. More than Just a Lack of Uniformity: Exploring the Evolution of Public Relations Master's Programs

    Science.gov (United States)

    Briones, Rowena L.; Shen, Hongmei; Parrish, Candace; Toth, Elizabeth L.; Russell, Maria

    2017-01-01

    Public relations is well known for its adaptability through continual change, and as a result, public relations master's programs have been re-conceptualized to remain rigorous and competitive. To further assess both the state and changes of these programs, 20 in-depth interviews were conducted with administrators of public relations master's…

  6. Using "The West Wing" for Problem-Based Learning in Public Relations Courses

    Science.gov (United States)

    Smudde, Peter M.; Luecke, John R.

    2005-01-01

    Integrating "The West Wing" in public relations courses can effectively dramatize the concrete and abstract dimensions of public relations. In turn, students see public relations in action (albeit fictionally so) and learn much about it through structured lessons. From individual writing assignments about situations in "The West Wing," to the…

  7. 48 CFR 231.205-1 - Public relations and advertising costs.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Public relations and... PROCEDURES Contracts With Commercial Organizations 231.205-1 Public relations and advertising costs. (e) See... public relations and advertising costs also include monies paid to the Government associated with the...

  8. Public Relations: The Route to Success and Influence. Public Relations for Your Library: A Tool for Effective Communications; Tooting Your Own Horn: Web-Based Public Relations for the School Media Specialist; Bookmarks as a Teaching Tool; Customers and Culture: The Who and What of Library Public Relations Efforts; Strategies for Successful Job Transition.

    Science.gov (United States)

    Lyon, Linda; Silverstein, Roberta; Fisher, Julieta Dias; Hill, Ann; Hegel, Claudette; Miller, Donna; Moyer, Mary

    2002-01-01

    This special section includes five articles that discuss public relations strategies for school librarians. Highlights include effective communication, including measuring and evaluating the success of public relations efforts; Web-based public relations; giving bookmarks to students; customers and cultural contexts; and successful job…

  9. U.S. Public Relations from an International Perspective: Curricular Issues and Objectives.

    Science.gov (United States)

    Pratt, Cornelius B.; Ogbondah, Chris W.

    This paper establishes a rationale for international public relations courses in the curricula of university public relations education in the U.S. and outlines the content of such courses. Disagreements between practitioners and educators on a blueprint for public relations education are documented. Developments pointing to a crucial need for…

  10. Public relations ve firmě LUMEN INTERNATIONAL a.s.

    OpenAIRE

    DICHTLOVÁ, Hana

    2012-01-01

    Goal of the thesis was to assess current significance and usage of public relations in LUMEN INTERNATIONAL a.s. company and to create plan of another development. The author analysed development and current situation of public relations in LUMEN holding. There are a few suggestions in this thesis how to improve public relations in whole LUMEN holding.

  11. Toward More Emphasis in International Public Relations Research and Education: A USA Perspective.

    Science.gov (United States)

    Neff, Bonita Dostal

    International public relations continues to be a rare experience in most public relations curriculums, but courses are found in journalism and business. The emphasis, however, is slightly different. Business departments emphasize international economic principles to be supported by public relations, whereas journalism stresses issues management…

  12. Professionalism in Public Relations Pedagogy: A Comparative Analysis of Public Relations Curricula among the United States, the United Kingdom, and South Korea

    Science.gov (United States)

    Chung, Wonjun; Choi, Jinbong

    2012-01-01

    Based on a concept of professionalism, this study analyzed and compared current public relations curricula of higher education among the United States, the United Kingdom, and South Korea. In terms of three educational orientations, results indicated that public relations education in the United States is the most balanced among theoretical,…

  13. The Necessity of Public Relations for Sustainable Mining Activities

    Science.gov (United States)

    Lee, Hyunbock; Ji, Sangwoo

    2015-04-01

    other hand, in the survey to determine what the greatest difficulties of the current mining activities, 54% of mining companies chose environmental regulations, 26% of mining companies chose conflicts between mine area residents and mining companies. Environmental regulations are may defined as the greatest difficulty of current mining activities. But most of environmental regulation's problems are caused by frictions with residents, because all of South Korean mines are very close to villages. So, the biggest difficulty of mining activities can be defined conflicts between residents and mining companies. Moreover, general people in South Korea including some mining engineers recognize the mining industry as a declined and pollution industry. Without clear understanding of mining activities, any mine developments and policies related to mining activities cannot be made by rational discussions. And, if their recognition is not formed in a rational way, it will be turned to extreme fear or blind hatred. Therefore, to understand mining activities correctly, the effective public relations strategy is necessary such as corporate advertisements or public advertisements.

  14. PUBLIC RELATIONS IN PUBLIC ADMINISTRATION: ROLE AND MANAGEMENT, IN A SOCIO-POLITICAL MARKETING CONTEXT

    Directory of Open Access Journals (Sweden)

    Dorian Pocovnicu

    2014-07-01

    Full Text Available Many agree that PR and marketing are at their best when used together, when it comes to local public administration institutions there is the need for both an individual and symbiotic approach of the two. Taking into consideration that public interest organizations act within public space, PR represents a public communication strategy. Thus they present the role of generating a climate and state of social normality and, especially in democratic societies, PR plays the part of generator of communication flows between public institutions, citizens and stakeholders. In a social-political marketing context, envisaged as an aggregate of processes, with a multiple purpose, the generator which is PR must unfold coherently for each of the processes. It is our purpose in this paper to depict the PR role and management in the case of one local public administration institution (Bacau Prefect Institution, in a socio-political marketing context.

  15. The Role of NOX4 and TRX2 in Angiogenesis and Their Potential Cross-Talk

    Directory of Open Access Journals (Sweden)

    Chaofei Chen

    2017-06-01

    Full Text Available The nicotinamide adenine dinucleotide phosphate (NADPH oxidase (NOX family is the major source of reactive oxygen species (ROS in the vascular system. In this family, NOX4, a constitutive active form of NOXs, plays an important role in angiogenesis. Thioredoxin 2 (TRX2 is a key mitochondrial redox protein that maintains normal protein function and also provides electrons to peroxiredoxin 3 (PRX3 to scavenge H2O2 in mitochondria. Angiogenesis, a process of new blood vessel formation, is involved in a variety of physiological processes and pathological conditions. It seems to be paradoxical for ROS-producing NOX4 and ROS-scavenging TRX2 to have a similar role in promoting angiogenesis. In this review, we will focus on data supporting the role of NOX4 and TRX2 in angiogenesis and their cross-talks and discuss how ROS can positively or negatively regulate angiogenesis, depending on their species, levels and locations. NOX4 and TRX2-mediated ROS signaling could be promising targets for the treatment of angiogenesis-related diseases.

  16. Oridonin inhibits tumor growth and metastasis through anti-angiogenesis by blocking the Notch signaling.

    Directory of Open Access Journals (Sweden)

    Yanmin Dong

    Full Text Available While significant progress has been made in understanding the anti-inflammatory and anti-proliferative effects of the natural diterpenoid component Oridonin on tumor cells, little is known about its effect on tumor angiogenesis or metastasis and on the underlying molecular mechanisms. In this study, Oridonin significantly suppressed human umbilical vascular endothelial cells (HUVECs proliferation, migration, and apillary-like structure formation in vitro. Using aortic ring assay and mouse corneal angiogenesis model, we found that Oridonin inhibited angiogenesis ex vivo and in vivo. In our animal experiments, Oridonin impeded tumor growth and metastasis. Immunohistochemistry analysis further revealed that the expression of CD31 and vWF protein in xenografts was remarkably decreased by the Oridonin. Furthermore, Oridonin reinforced endothelial cell-cell junction and impaired breast cancer cell transendothelial migration. Mechanistically, Oridonin not only down-regulated Jagged2 expression and Notch1 activity but also decreased the expression of their target genes. In conclusion, our results demonstrated an original role of Oridonin in inhibiting tumor angiogenesis and propose a mechanism. This study also provides new evidence supporting the central role of Notch in tumor angiogenesis and suggests that Oridonin could be a potential drug candidate for angiogenesis related diseases.

  17. Modeling angiogenesis with micro- and nanotechnology.

    Science.gov (United States)

    Chen, Li-Jiun; Kaji, Hirokazu

    2017-12-05

    Angiogenesis plays an important role not only in the growth and regeneration of tissues in humans but also in pathological conditions such as inflammation, degenerative disease and the formation of tumors. Angiogenesis is also vital in thick engineered tissues and constructs, such as those for the heart and bone, as these can face difficulties in successful implantation if they are insufficiently vascularized or unable to connect to the host vasculature. Considerable research has been carried out on angiogenic processes using a variety of approaches. Pathological angiogenesis has been analyzed at the cellular level through investigation of cell migration and interactions, modeling tissue level interactions between engineered blood vessels and whole organs, and elucidating signaling pathways involved in different angiogenic stimuli. Approaches to regenerative angiogenesis in ischemic tissues or wound repair focus on the vascularization of tissues, which can be broadly classified into two categories: scaffolds to direct and facilitate tissue growth and targeted delivery of genes, cells, growth factors or drugs that promote the regeneration. With technological advancement, models have been designed and fabricated to recapitulate the innate microenvironment. Moreover, engineered constructs provide not only a scaffold for tissue ingrowth but a reservoir of agents that can be controllably released for therapeutic purposes. This review summarizes the current approaches for modeling pathological and regenerative angiogenesis in the context of micro-/nanotechnology and seeks to bridge these two seemingly distant aspects of angiogenesis. The ultimate aim is to provide insights and advances from various models in the realm of angiogenesis studies that can be applied to clinical situations.

  18. Angiogenesis as a prognostic indicator in pancreatic ductal adenocarcinoma.

    Science.gov (United States)

    Stipa, F; Lucandri, G; Limiti, M R; Bartolucci, P; Cavallini, M; Di Carlo, V; D'Amato, A; Ribotta, G; Stipa, S

    2002-01-01

    Angiogenesis has gained wide acceptance as a reliable prognostic factor in several solid tumors. However, to date, experience in pancreatic adenocarcinoma is limited. Specimens from 45 patients radically operated on at our departments from 1988 to 1997 were stained immunohistochemically with the antibodies anti-mutant p53, anti-bcl2, anti Ki67 and anti-CD31. All the slides were reviewed by the same pathologist without knowledge of the patients' outcome. Mutant p53, Ki67 index and vessel count were significantly related to tumoral behaviour and patients' outcome. Among patients with nodal involvement (Stage III), cumulative survival between hypovascular and hypervascular subgroups differed significantly (p = 0.03). Angiogenesis was independent from TNM in assessing the patients'prognosis at COX analysis (p = 0.02). In patients with pancreatic adenocarcinoma, angiogenesis is a reliable indicator of tumor extension, lymph node status and survival. Its evaluation as a common procedure may contribute to a further improvement in the management of these patients and to a proper selection of those who could benefit from different follow-up protocols or adjuvant treatment.

  19. Healthy public relations: the FDA's 1930s legislative campaign.

    Science.gov (United States)

    Kay, G

    2001-01-01

    In this article, I argue that the Food and Drug Administration (FDA) is an oft-overlooked government agency that acts to preserve and secure the public's health. From its early years as an agency charged with enforcement of the 1906 Pure Food and Drugs Act, the FDA not only protected the public's health but also made the public aware of its mission, using methods as diverse as displays at county fairs and at the 1933 Chicago World's Fair, radio programming, and active correspondence. The agency encouraged the public to protect itself, particularly in those arenas in which the FDA had no regulatory authority. In addition, it may have overstepped its boundaries when it actively solicited public support for a bill submitted to Congress in the early 1930s. In the dark days of the Great Depression, the FDA contended not only with limited resources and its own feelings of inadequacy in terms of what could and could not be done to protect the populace, but also with "guinea pig" books that horrified and angered many readers. By 1938, when the agency prevailed and the revisions to the 1906 Act passed Congress and were signed into law by President Franklin D. Roosevelt, the FDA had done all that a responsible public health agency should do, and more.

  20. A novel in vitro assay for human angiogenesis.

    Science.gov (United States)

    Brown, K J; Maynes, S F; Bezos, A; Maguire, D J; Ford, M D; Parish, C R

    1996-10-01

    Angiogenesis, the development of new blood vessels, is an important process in tissue development and wound healing but becomes pathologic when associated with solid tumor growth, proliferative retinopathies, and rheumatoid arthritis. To date, there has not been a physiologically relevant in vitro model for human angiogenesis that can be used to screen for enhancers and inhibitors of human angiogenesis and allow further investigation of this process. Initially, culture conditions were established for the induction of human angiogenesis in vitro using fragments of human placental blood vessel. Once the assay was validated, it was examined for its ability to detect known inhibitors and enhancers of angiogenesis. The role of endogenous acidic fibroblast growth factor (aFGF), basic fibroblast growth factor (bFGF), and vascular endothelial growth factor (VEGF) in the angiogenic response was also assessed by performing RT-PCR on both the parent vessel and microvessel outgrowths. In addition, neutralizing antibodies against the three growth factors were used to quantify the relative importance of each growth factor in the angiogenic response. A fragment of human placental blood vessel was embedded in a fibrin gel in microculture plates and was found to give rise to a complex network of microvessels during a period of 7 to 21 days in culture. The response did not require the addition of exogenous growth factors, and thus provides a convenient system for testing substances for their ability to stimulate or inhibit a human in vitro angiogenic response. The ability of the well known angiogenesis antagonist, hydrocortisone, in the presence and absence of heparin, and suramin to significantly inhibit the angiogenic response indicated that the model could be used as an efficient in vitro assay for screening inhibitors of human angiogenesis. The presence of mRNA for aFGF, bFGF, and three isoforms of VEGF, as well as their receptors, FGFR1, FGFR2, Flt-1, and KDR, in vessel

  1. Hypoxia and Angiogenesis in Endometrioid Endometrial Carcinogenesis

    Directory of Open Access Journals (Sweden)

    Nicole Horrée

    2007-01-01

    Full Text Available Background: Hypoxia-inducible factor 1α (HIF-1α plays an essential role in the adaptive response of cells to hypoxia, triggering biologic events associated with aggressive tumor behavior. Methods: Expression of HIF-1α and proteins in the HIF-1α pathway (Glut-1, CAIX, VEGF in paraffin-embedded specimens of normal (n = 17, premalignant (n = 17 and endometrioid endometrial carcinoma (n = 39 was explored by immunohistochemistry, in relation to microvessel density (MVD. Results: HIF-1α overexpression was absent in inactive endometrium but present in hyperplasia (61% and carcinoma (87%, with increasing expression in a perinecrotic fashion pointing to underlying hypoxia. No membranous expression of Glut-1 and CAIX was noticed in inactive endometrium, in contrast with expression in hyperplasia (Glut-1 0%, CAIX 61%, only focal and diffuse and carcinoma (Glut-1 94.6%, CAIX 92%, both mostly perinecrotically. Diffuse HIF-1α was accompanied by activation of downstream targets. VEGF was significantly higher expressed in hyperplasias and carcinomas compared to inactive endometrium. MVD was higher in hyperplasias and carcinomas than in normal endometrium (p < 0.001. Conclusion: HIF-1α and its downstream genes are increasingly expressed from normal through premalignant to endometrioid adenocarcinoma of the endometrium, paralleled by activation of its downstream genes and increased angiogenesis. This underlines the potential importance of hypoxia and its key regulator HIF-1α in endometrial carcinogenesis.

  2. The effects of radiation on angiogenesis.

    Science.gov (United States)

    Grabham, Peter; Sharma, Preety

    2013-10-26

    The average human body contains tens of thousands of miles of vessels that permeate every tissue down to the microscopic level. This makes the human vasculature a prime target for an agent like radiation that originates from a source and passes through the body. Exposure to radiation released during nuclear accidents and explosions, or during cancer radiotherapy, is well known to cause vascular pathologies because of the ionizing effects of electromagnetic radiations (photons) such as gamma rays. There is however, another type of less well-known radiation - charged ion particles, and these atoms stripped of electrons, have different physical properties to the photons of electromagnetic radiation. They are either found in space or created on earth by particle collider facilities, and are of significant recent interest due to their enhanced effectiveness and increasing use in cancer radiotherapy, as well as a health risk to the growing number of people spending time in the space environment. Although there is to date, relatively few studies on the effects of charged particles on the vascular system, a very different picture of the biological effects of these particles compared to photons is beginning to emerge. These under researched biological effects of ion particles have a large impact on the health consequences of exposure. In this short review, we will discuss the effects of charged particles on an important biological process of the vascular system, angiogenesis, which creates and maintains the vasculature and is highly important in tumor vasculogenesis.

  3. A bibliography of IRIS-related publications, 2000-2011

    Science.gov (United States)

    Muco, B.

    2012-12-01

    Citations and acknowledgements in scientific journals can be an indicator of the role an organization has on the research of that field. Since its formation and incorporation in May 1984, the IRIS Consortium (Incorporated Research Institutions for Seismology) is mentioned more and more as a valuable source of data, instruments and programs in the literature of earth sciences. As a large organization with more than 100 member domestic institutes and about 40 international affiliates, obviously IRIS has a direct impact on the earth sciences through all its programs, projects, workshops, symposia, and news¬letters and as a lively forum for exchanging ideas. In order to maintain support from National Science Foundation (NSF) and the research community, it is important to document the continued use of IRIS facilities in basic research programs. IRIS maintains a database of articles that are based on the use of IRIS facilities or which reference use of IRIS data and resources. Articles in this database have been either been provided to IRIS by the authors or selected through an annual search of a number of prominent journals. A text version of the full bibliographic database is available on the IRIS website and a version in EndNote format is also provided. To provide a more complete bibliography and a consistent evaluation of temporal tends in publications, a special annual search began in 2000 which focused on a subset of key seismology and Earth science journals: Bulletin of Seismological Society of America, Journal of Geophysical Research, Seismological Research Letters, Geophysical Research Letters, Earth and Planetary Science Letters, Physics of the Earth and Planetary Interiors, Tectonophysics, Geophysical Journal International, Nature, Science, Geology and EOS. Using different search engines as Scirus, ScienceDirect, GeoRef, OCLC First Search, EASI Search, NASA Abstract Service etc. for online journals and publishers' databases, we searched for key words (IRIS

  4. Angiogenesis is inhibitory for mammalian digit regeneration

    Science.gov (United States)

    Yu, Ling; Yan, Mingquan; Simkin, Jennifer; Ketcham, Paulina D.; Leininger, Eric; Han, Manjong

    2014-01-01

    Abstract The regenerating mouse digit tip is a unique model for investigating blastema formation and epimorphic regeneration in mammals. The blastema is characteristically avascular and we previously reported that blastema expression of a known anti‐angiogenic factor gene, Pedf, correlated with a successful regenerative response (Yu, L., Han, M., Yan, M., Lee, E. C., Lee, J. & Muneoka, K. (2010). BMP signaling induces digit regeneration in neonatal mice. Development, 137, 551–559). Here we show that during regeneration Vegfa transcripts are not detected in the blastema but are expressed at the onset of differentiation. Treating the amputation wound with vascular endothelial growth factor enhances angiogenesis but inhibits regeneration. We next tested bone morphogenetic protein 9 (BMP9), another known mediator of angiogenesis, and found that BMP9 is also a potent inhibitor of digit tip regeneration. BMP9 induces Vegfa expression in the digit stump suggesting that regenerative failure is mediated by enhanced angiogenesis. Finally, we show that BMP9 inhibition of regeneration is completely rescued by treatment with pigment epithelium‐derived factor. These studies show that precocious angiogenesis is inhibitory for regeneration, and provide compelling evidence that the regulation of angiogenesis is a critical factor in designing therapies aimed at stimulating mammalian regeneration. PMID:27499862

  5. Publicity as policy: the changing role of press and public relations at the BMA, 1940s-80s.

    Science.gov (United States)

    Loughlin, Kelly

    2005-01-01

    Relationships between policy and publicity or public relations (PR) have been questioned since the emergence of professional public relations in the early-twentieth century. In the field of health and medicine organised PR activity began to flourish in the decades following World War Two. Its presence became evident in government departments, in professional associations, voluntary bodies and campaigning groups. Increasingly, policy decisions had to be publicly performed through rituals like the press conference. This chapter documents the development of press and PR activity at the British Medical Association (BMA) from the 1950s to the 1980s. The BMA provides a well-documented case, which can be used to suggest broader shifts in the association between policy and publicity.

  6. Customer Relations Management sebagai Salah Satu Upaya Public Relations Perusahaan Jasa Perbankan Menciptakan Good Image

    Directory of Open Access Journals (Sweden)

    Prima Ayu Rizqi Mahanani

    2017-01-01

    Full Text Available This article deals with marketing trends in the 21st century is shifting from a transactional approach to the relational approach with focus on the fulfillment of needs, satisfaction, and pleasure affect business banking customers are very dependent on the customer. Map business services banking services fickle demands creativity public relations in providing the best service to its customers get a good image. Service concept using the service paradigm leading to cultivate the power of the customer based on the customer satisfaction-oriented, widely used by business banking services at this time. Paradigms that focus on how to provide services to the customer so that the customer was satisfied, beyond what can be given to something that is important and not to be underestimated. Skills to understand and fulfill customer expectations should be every company’s business philosophy of banking services and customer relationship management is a strategy

  7. Ethical practice of social media in public relations

    CERN Document Server

    DiStaso, Marcia W

    2014-01-01

    Given the high rate of social media use by the public, organizations are compelled to engage with key audiences through these outlets. Social media engagement requires organizations to actively participate with public groups, and this highly-interactive exchange raises a new set of ethical concerns for communicators. In this rapidly changing communications environment, the long-term implications of social media are uncertain, and this book provides the much needed research to understand its impact on audiences and organizations.Through an examination of a broad range of ethics concepts includi

  8. Building Strong Bonds with Program Sponsors--Public Relations Ideas To Make It Happen.

    Science.gov (United States)

    Stephens, Karen

    2003-01-01

    Lists public relations strategies for child care center directors seeking to cultivate relationships with their program sponsors. Suggests ways to identify a public relations message, make the sponsor part of the child care family, become part of the sponsor's family, give public recognition, and share the children's accomplishments. (JPB)

  9. 76 FR 26296 - Public Availability of Federal Labor Relations Authority FY 2010 Service Contract Inventory

    Science.gov (United States)

    2011-05-06

    ... FEDERAL LABOR RELATIONS AUTHORITY Public Availability of Federal Labor Relations Authority FY 2010 Service Contract Inventory AGENCY: Federal Labor Relations Authority. ACTION: Notice of Public... the Consolidated Appropriations Act of 2010 (Pub. L. 111-117), the Federal Labor Relations Authority...

  10. 77 FR 1689 - Public Availability of Federal Labor Relations Authority FY 2011 Service Contract Inventory

    Science.gov (United States)

    2012-01-11

    ... FEDERAL LABOR RELATIONS AUTHORITY Public Availability of Federal Labor Relations Authority FY 2011 Service Contract Inventory AGENCY: Federal Labor Relations Authority. ACTION: Notice of Public... the Consolidated Appropriations Act of 2010 (Pub. L. 111-117), the Federal Labor Relations Authority...

  11. 77 FR 5062 - Public Availability of National Labor Relations Board's FY 2011 Service Contract Inventory

    Science.gov (United States)

    2012-02-01

    ... NATIONAL LABOR RELATIONS BOARD Public Availability of National Labor Relations Board's FY 2011 Service Contract Inventory AGENCY: National Labor Relations Board. ACTION: Notice of public availability... Consolidated Appropriations Act of 2010 (Pub. L. 111-117), the National Labor Relations Board (NLRB) is...

  12. 76 FR 40937 - Public Availability of National Labor Relations Board's FY 2010 Service Contract Inventory

    Science.gov (United States)

    2011-07-12

    ... NATIONAL LABOR RELATIONS BOARD Public Availability of National Labor Relations Board's FY 2010 Service Contract Inventory AGENCY: National Labor Relations Board. ACTION: Notice of public availability... Consolidated Appropriations Act of 2010 (Pub. L. 111-117), the National Labor Relations Board (NLRB) is...

  13. Public Relations Opportunities for Schools Utilizing Innovations in Virtual Communities

    Science.gov (United States)

    O'Reilly, Frances L.; Matt, John J.

    2013-01-01

    With the dawn of the Information Age, schools, along with other organizations, must take note of the varied ways individuals and groups in society are communicating. Today, with the many forms of communication, most information is made public in real time. In a qualitative national study in the United States, respondents identified positive and…

  14. Social Media, Traditional Media and Marketing Communication of Public Relations:A Study of Banking Industry

    OpenAIRE

    Khajeheian, Datis; Mirahmadi, Fereshteh

    2015-01-01

    Public relations are undertaking more important role in the marketing communication and advertising. The present paper reports a survey conducted in three Iranian banks’ public relations departments to understand how they use different media in their marketing communications and other related functions. A classification of public relations functions including fourteen functions in three categories has taken as research framework and by using a questionnaire, eight media have been asked to ran...

  15. COX-2, VEGF and tumour angiogenesis.

    LENUS (Irish Health Repository)

    Toomey, D P

    2009-06-01

    Epidemiological evidence suggests a protective effective of regular NSAID use against developing cancer. Cyclooxygenase-2, a target of NSAIDs, is upregulated in many cancers and has been associated with increased VEGF production and angiogenesis. Angiogenesis is the formation of new vessels from existing vasculature and as an essential process for tumour development represents an important therapeutic target. Following an extensive review of the literature this article details the current knowledge on the role of COX-2 in tumorigenesis focusing on its relationship to angiogenesis and VEGF production by tumour cells. While COX-2 is clearly detrimental to prognosis and NSAIDs have a beneficial effect, the possibility of COX-2 independent effects being partly or wholly responsible for this benefit cannot be excluded.

  16. Mesoscopic and continuum modelling of angiogenesis

    KAUST Repository

    Spill, F.

    2014-03-11

    Angiogenesis is the formation of new blood vessels from pre-existing ones in response to chemical signals secreted by, for example, a wound or a tumour. In this paper, we propose a mesoscopic lattice-based model of angiogenesis, in which processes that include proliferation and cell movement are considered as stochastic events. By studying the dependence of the model on the lattice spacing and the number of cells involved, we are able to derive the deterministic continuum limit of our equations and compare it to similar existing models of angiogenesis. We further identify conditions under which the use of continuum models is justified, and others for which stochastic or discrete effects dominate. We also compare different stochastic models for the movement of endothelial tip cells which have the same macroscopic, deterministic behaviour, but lead to markedly different behaviour in terms of production of new vessel cells. © 2014 Springer-Verlag Berlin Heidelberg.

  17. Penerapan Peran Public Relations Pada Program Employee Relations Sebagai Upaya Meningkatkan Loyalitas Karyawan.(Studi Kasus tentang Penerapan Peran Public Relations Pada Program Employee Relations Oleh Divisi Human Capital Development PT. Kao Indonesia)

    OpenAIRE

    Irawan, Enjang Pera

    2018-01-01

    This study titled: Application of Public Relations Role in Employee Relations Program as an Effort to Increase Employee Loyalty. The object of this research is PT. Kao Indonesia. The background of this research is due to the employee relations program at PT. Kao Indonesia is conducted by the Division of Human Capital Development, but in It’s implementation  on daily life it’s adopt the role and tasks of Public Relations. This study aims to examine and analyze how the implementation of Public ...

  18. Do Public Relations and Journalism’s Converging Roles Affect How They Perceive Each Other?

    DEFF Research Database (Denmark)

    Valentini, Chiara

    2014-01-01

    Media relations is historically a core activity qualifying public relations from other communication-related professions and is widely practiced in many organizations. Despite the increasing use of digital media to directly communicate with publics, journalists are still key stakeholders...... for organizations. Also communications by organizations have become more and more mediatized and at the same time more and more journalists are switching to a public relations career. Yet, if more journalists are becoming public relations practitioners and more public relations practitioners are adopting...... journalistic working practices, does this change the way these communicators perceive themselves and the other profession? The aim of this study is to provide some insights from a southern, Latin country, Italy, on how Italian public relations practitioners and journalists perceive their and the other...

  19. Oshkosh Logistic Management and Public Relations Responsibilities at NASA Langley

    Science.gov (United States)

    Beck, Danielle

    1995-01-01

    The central focus of my study for the summer of 1995 was to provide logistical support to Margaret Hunt, the logistics manager of the OSHKOSH airshow. In this capacity responsibilities included making arrangements for participants from NASA centers and SBIR companies for their stay in Wisconsin, while visiting the airshow, and managing staff for exhibits and the aerospace theater. A secondary purpose was to serve in other public service capacities by writing news releases, fact sheets, announcements, and articles for the Researcher News.

  20. Adoption of Social Media for Public Relations by Museums

    OpenAIRE

    Bojana Suzić; Miroslav Karlíček; Václav Stříteský

    2016-01-01

    Conceptual evolution of the Internet and Web, substantiated through Web 2.0 and the emergence of online social networks, reinvented the way that enterprises interact with their customers. Museums, as cultural institutions with an important mission, are not unaffected by that change, however. In order to fulfil their duties and societal purpose successfully, they have to attract visitors’ attention and engage the public effectively in a highly competitive and saturated environment. The goal of...

  1. MANAJEMEN KRISIS PUBLIC RELATIONS (STUDI KASUS TENTANG PERAN PUBLIC RELATIONS BADAN PENGEMBANGAN WILAYAH SURAMADU (BPWS DALAM MENGHADAPI RESISTENSI MASYARAKAT MADURA DI KABUPATEN BANGKALAN TERHADAP KEHADIRAN LEMBAGANYA

    Directory of Open Access Journals (Sweden)

    Roos Yuliastina

    2017-03-01

    Full Text Available ABSTRAKPenelitian ini ingin mengetahui peran public relations dan metode pendekatan public relations BPWS dalam menghadapi resistensi masyarakat Madura di Kabupaten Bangkalan terhadap kehadiranlembaganya. Dengan mengkaji peran dan model pendekatannya, diharapkan dapat mengetahui jugabagaimana public relations BPWS mengatasi manajemen krisis. Karena jika perbedaan kepentinganantara BPWS dengan masyarakat Madura terus dibiarkan, bukan tidak mungkin masalah ini akanmenjadi krisis berkepanjangan yang mengancam eksistensi BPWS. Metode yang digunakan adalah metode kulitatif, metode ini lebih menekankan pada kedalamanyang diteliti (kualitas data yang telah di peroleh, bukan pada banyaknya (kuantitas data. Teknikpengumpulan data mencakup informan atau narasumber yang paham dan terlibat secara langsungdalam kasus ini. Pengumpulan datanya menggunakan data primer dan skunder. Teknik analisis datamenggunakan teknik analisis data kualitatif, untuk validitas datanya menggunakan triangulasi datadan triangulasi sumber. Hasil penelitian menunjukkan bahwa, Peran public relations dalam menghadapi resistensi masyarakatMadura di Kabupaten Bangkalan terhadap BPWS lebih berperan sebagai fasilitator komunikasi.Model pendekatan yang diterapkan adalah model public relations pengaruh personal (personalinfluence model yang di kategorikan kedalam model publik relations asimetris dua arah. Tahapantahapanmanajemen krisis untuk mengatasikasus ini, terdiridari tiga tahapan.Yaitutahapanprakrisis,meresponkrisis, dan pasca-krisis.Kata Kunci: Manajemen Krisis, Public relations BPWS, resistensi masyarakat Madura di KabupatenBangkalan.

  2. Preclinical MRI experience in imaging angiogenesis.

    Science.gov (United States)

    Neeman, M

    2000-01-01

    Magnetic resonance imaging (MRI) provides a range of non-invasive measures for visualization of tumor angiogenesis in the clinic as well as in experimental tumor models. MRI methods were developed for assessment of spatial and temporal changes in perfusion, blood volume fraction, vascular permeability, vascular function, vascular maturation, vessel diameter and tortuosity. Molecular targeted contrast agents were used for mapping specific markers of neovasculature. These approaches were applied for analysis of a number of regulatory mechanisms controlling tumor angiogenesis and for preclinical evaluation of tumor response to antiangiogenic agents.

  3. Targeted microbubbles for imaging tumor angiogenesis: assessment of whole-body biodistribution with dynamic micro-PET in mice

    DEFF Research Database (Denmark)

    Willmann, Jürgen K; Cheng, Zhen; Davis, Corrine

    2008-01-01

    To evaluate in vivo whole-body biodistribution of microbubbles (MBs) targeted to tumor angiogenesis-related vascular endothelial growth factor (VEGF) receptor 2 (VEGFR2) by using dynamic micro-positron emission tomography (PET) in living mice....

  4. How to implement a successful business-to-business public relations program

    International Nuclear Information System (INIS)

    Narup, C.; Narup, W.J.

    1991-01-01

    This paper discusses public relations as it relates to marketing of business or industrial products. While the paper is written generically, it is submitted as part of a conference for the oil, gas, and petrochemical industry. The idea of public relations is defined and goes on to discuss using public relations to introduce new products and services, generate sales, evaluate media response, develop community relationships, and carry out initial research on the product or service. The article gives case studies of good public relation campaigns and the results on the company image and business profits

  5. Effect of a public relations staff member on new patient visits in an established private practice.

    Science.gov (United States)

    Nacht, E S; Trupkin, D; Trilnik, E

    1992-01-01

    The purpose of this study is to relate the short-term effect of implementation of a public relations program (internal marketing), utilizing a public relations staff member (PRSM) in an established pediatric dental private practice. The public relations staff member performed numerous duties previously performed by many staff members. The results showed an increase in new patients for the six months studied between 22 percent to 111 percent. The number of Hispanic new patients was also compared and also increased significantly. Consideration should be given to having a public relations staff member to handle all incoming calls.

  6. Review of Selected Dissertations Relevant to the "Journal of School Public Relations"

    Science.gov (United States)

    Hurtado, DeAnn; McCue, Lesley

    2012-01-01

    The article provides summaries of doctoral dissertations completed between January 2008 and December 2011 addressing foci of the "Journal of School Public Relations". The five areas are public relations, communication, school and community relations, conflict management, and human resources management. The periodic summaries of these dissertations…

  7. The development of public relations at the Dukovany nuclear power plant

    International Nuclear Information System (INIS)

    Rerucha, F.; Urbasek, R.

    2000-01-01

    The article describes the development of mutual relations between the Dukovany NPP and the public and institutions within the region and presents evaluation of the current status and topical tasks for the benefit of a further progress in such relations. The importance is stressed of the role of the communication process, preparation and purposefulness of the forms and methods in implementing the communication policy by the NPP's Public Relations department towards individual target groups of the public. (author)

  8. Importance Of Public Relations In Natural Stone Mining And Its Contribution To The Industry

    OpenAIRE

    DEMİR, Behzat Gökçen; ÖNENÇ, Deniz İskender; GÜNGÖR, Nusret; AKBULUT, Akın

    2014-01-01

    All activities done in marble and natural stone industry has a social dimension. Mining continued serious work in all branches of international companies before the creation of a sustanaible culture of marble social dimension of public relations in the foreground is the driving force. Sustainable and professional public relations policy, marble-work capacity improves the natural stone industry. Public relations, stakeholders or the general term of communication bridge between the industry and...

  9. A Study on the Relationship between Public Relations and Brand Strategy

    OpenAIRE

    Xu, Yuanzhong (Victor)

    2005-01-01

    Brand strategy is a useful way to strengthen competitive competence of products. However, the researches on how to implement a successful brand strategy using public relations were rarely found in the existing literature. The main purpose with my dissertation is to investigate the relationship between public relations and brand strategy. In addition, I hope the dissertation can give some suggestions to Chinese companies when they want to implement a brand strategy using public relations. A ...

  10. The Role of Public Relations as A Management Function in Higher Education

    OpenAIRE

    Anggreni Putri

    2018-01-01

    Nowadays, public relations in higher education institution become an integral part of the management team. It must contribute to achieve organizational goals and demonstrate an organizational accountability identified by measurable result. Placement public relations at certain positions in management has consequences in the process of implementation of the public relations function. It happened because the management, workflow and hierarchy greatly affects work patterns as well as patterns of...

  11. School Related Factors as Predictors of Internal Efficiency of Public ...

    African Journals Online (AJOL)

    Nneka Umera-Okeke

    constructed questionnaire tagged 'School Related Factors and Internal Efficiency. Questionnaire' (SRFIEQ) was ... related factors (students/teacher, curriculum deficiency and school organizational climate) and internal efficiency .... universities are not relevant to the needs of the labour market. He stressed that the lecturers ...

  12. HIF-2alpha-dependent PAI-1 induction contributes to angiogenesis in hepatocellular carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Geis, Theresa, E-mail: geis@biochem.uni-frankfurt.de [Institute of Biochemistry I—Pathobiochemistry, Faculty of Medicine, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main (Germany); Döring, Claudia, E-mail: C.Doering@em.uni-frankfurt.de [Dr. Senckenberg Institute of Pathology, Faculty of Medicine, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main (Germany); Popp, Rüdiger, E-mail: popp@vrc.uni-frankfurt.de [Institute for Vascular Signalling, Centre for Molecular Medicine, Faculty of Medicine Medicine, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60596 Frankfurt am Main (Germany); Grossmann, Nina, E-mail: grossmann@biochem.uni-frankfurt.de [Institute of Biochemistry I—Pathobiochemistry, Faculty of Medicine, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main (Germany); Fleming, Ingrid, E-mail: fleming@vrc.uni-frankfurt.de [Institute for Vascular Signalling, Centre for Molecular Medicine, Faculty of Medicine Medicine, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60596 Frankfurt am Main (Germany); Hansmann, Martin-Leo, E-mail: m.l.hansmann@em.uni-frankfurt.de [Dr. Senckenberg Institute of Pathology, Faculty of Medicine, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main (Germany); Dehne, Nathalie, E-mail: dehne@biochem.uni-frankfurt.de [Institute of Biochemistry I—Pathobiochemistry, Faculty of Medicine, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main (Germany); Brüne, Bernhard, E-mail: b.bruene@biochem.uni-frankfurt.de [Institute of Biochemistry I—Pathobiochemistry, Faculty of Medicine, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main (Germany)

    2015-02-01

    Hypoxia promotes progression of hepatocellular carcinoma (HCC), not only affecting tumor cell proliferation and invasion, but also angiogenesis and thus, increasing the risk of metastasis. Hypoxia inducible factors (HIF)-1α and -2α cause adaptation of tumors to hypoxia, still with uncertainties towards the angiogenic switch. We created a stable knockdown of HIF-1α and HIF-2α in HepG2 cells and generated cocultures of HepG2 spheroids with embryonic bodies as an in vitro tumor model mimicking the cancer microenvironment. The naturally occuring oxygen and nutrient gradients within the cocultures allow us to question the role of distinct HIF isoforms in regulating HCC angiogenesis. In cocultures with a HIF-2α knockdown, angiogenesis was attenuated, while the knockdown of HIF-1α was without effect. Microarray analysis identified plasminogen activator inhibitor 1 (PAI-1) as a HIF-2α target gene in HepG2 cells. The knockdown of PAI-1 in HepG2 cells also lowered angiogenesis. Blocking plasmin, the downstream target of PAI-1, with aprotinin in HIF-2α knockdown (k/d) cells proved a cause–effect relation and restored angiogenesis, with no effect on control cocultures. Suggestively, HIF-2α increases PAI-1 to lower concentrations of active plasmin, thereby supporting angiogenesis. We conclude that the HIF-2α target gene PAI-1 favors the angiogenic switch in HCC. - Highlights: • HepG2 were cocultured with stem cells to mimic a cancer microenvironment in vitro. • A knockdown of HIF-2α reduces angiogenesis. • PAI-1 was identified as a HIF-2α target gene in HCC by microarray analysis. • HIF-2α induces the angiogenic switch via inhibition of plasmin.

  13. How the largest electric and gas utility companies administer public relations

    Energy Technology Data Exchange (ETDEWEB)

    Bogart, J.D.

    1979-04-12

    This article describes the findings of a survey conducted by the author in the second half of 1978 to determine the sizes of the public relations staffs of the nation's largest operating electric and gas utilities, their budgets, organizational differences, and specific functions. Common public relations issues and major public relations problems of the utilities are identified, as well as recent trends or changes in budgeting and organization. Some functional variations of public relations departments among utility companies were detected and described.

  14. Advances and challenges in skeletal muscle angiogenesis

    DEFF Research Database (Denmark)

    Olfert, I Mark; Baum, Oliver; Hellsten, Ylva

    2016-01-01

    The role of capillaries is to serve as the interface for delivery of oxygen and removal of metabolites to/from tissues. During the past decade there has been a proliferation of studies that have advanced our understanding of angiogenesis demonstrating tissue capillary supply is under strict control...

  15. Fibromodulin Enhances Angiogenesis during Cutaneous Wound Healing

    Directory of Open Access Journals (Sweden)

    Zhong Zheng, PhD

    2014-12-01

    Conclusions: Altogether, we demonstrated that in addition to reducing scar formation, FMOD also promotes angiogenesis. As blood vessels organize and regulate wound healing, its potent angiogenic properties will further expand the clinical application of FMOD for cutaneous healing of poorly vascularized wounds.

  16. Monitoring angiogenesis using magnetic resonance methods

    DEFF Research Database (Denmark)

    Holm, David Alberg

    2008-01-01

    When a tumor reaches a certain size it can no longer rely on passive perfusion for nutrition. The tumor therefore emits signaling molecules which stimulating surrounding vessels to divide and grow towards the tumor, a process known as angiogenesis. Very little angiogenesis is present in healthy a...... in a transgenic mouse model. The last manuscript presents a new method for in vivo cell labeling. This method could find use in studying the metastatic spread of cancer cells throughout the body.......-angiogenic treatment is presented in the first manuscript. In the second and third manuscript, two separate methods of quantifying perfusion, blood volume and vessel permeability are presented. The methods are used to show that drug delivery to a xenografted tumor is plausible and to show possible vascular maturation...... and the involved signaling molecules. Subsequently, a short review of contrast agents and perfusion measurements is given. Finally, methods for monitoring angiogenesis using magnetic resonance imaging are reviewed. A method for monitoring early stages of angiogenesis as well as the effect of anti...

  17. Their function on angiogenesis and cellular signalling

    Indian Academy of Sciences (India)

    Copper, although known as a micronutrient, has a pivotal role in modulating the cellular metabolism. Many studieshave reported the role of copper in angiogenesis. Copper chaperones are intracellular proteins that mediate coppertrafficking to various cell organelles. However, the role and function of copper chaperones in ...

  18. Life on the Bleeding Edge: Philosophy, Practice, and Public Relations in Charter Schools

    Science.gov (United States)

    Perreault, George

    2004-01-01

    Charter schools represent one of the most intriguing developments within public education in the past decade. Although they vary widely among themselves and differ from regular public schools in some regards, they also show many similarities. Consequently, many of the public relations strategies that work for other schools should also be useful…

  19. Integrating Public Relations and Legal Responses during a Crisis: The Case of Odwalla, Inc.

    Science.gov (United States)

    Martinelli, Kathleen A.; Briggs, William

    1998-01-01

    Examines the crisis-communication strategies employed by Odwalla, Inc. during its juice contamination crisis, a crisis whose impact on public health and safety gave it the potential for developing into an issue that required public policy relief. Finds that public-relations response strategies dominated legal response strategies, followed by mixed…

  20. Successful public relations for a better public acceptance - a case study on Sellafield

    International Nuclear Information System (INIS)

    Duncan, C.; Prestwood, J.

    1998-01-01

    The Sellafield story is not unique but it can be used as one example of what can be achieved in a community close to a nuclear site. Over the past 12 years BNFL staff at Sellafield have worked diligently to win public acceptance in the local community around Sellafield. It has been an excellent example of teamwork, involving the workforce and the local community. It has taken a great deal of effort and finance and painstaking attention to even the most trivial issues to gain the publics' trust. Today, Sellafield and its activities underpin the economy of West Cumbria. The site employs just under 7000 people directly with a further 1500 in contracting roles

  1. Successful public relations for a better public acceptance - a case study on Sellafield

    Energy Technology Data Exchange (ETDEWEB)

    Duncan, C. [British Nuclear Fuels plc, Risley (United Kingdom); Prestwood, J. [British Nuclear Fuels plc, Sellafield (United Kingdom)

    1998-12-31

    The Sellafield story is not unique but it can be used as one example of what can be achieved in a community close to a nuclear site. Over the past 12 years BNFL staff at Sellafield have worked diligently to win public acceptance in the local community around Sellafield. It has been an excellent example of teamwork, involving the workforce and the local community. It has taken a great deal of effort and finance and painstaking attention to even the most trivial issues to gain the publics` trust. Today, Sellafield and its activities underpin the economy of West Cumbria. The site employs just under 7000 people directly with a further 1500 in contracting roles.

  2. Sponsorship of physical activity programs by the sweetened beverages industry: public health or public relations?

    Science.gov (United States)

    Gómez, Luis; Jacoby, Enrique; Ibarra, Lorena; Lucumí, Diego; Hernandez, Alexandra; Parra, Diana; Florindo, Alex; Hallal, Pedro

    2011-04-01

    The growing evidence on the association between consumption of sugar-sweetened beverages, obesity and other chronic diseases has highlighted the need to implement policy actions that go beyond programs exclusively focused on individual responsibility. In order to protect their commercial goals in Latin America, the sugar-sweetened beverage industry practices intense lobbying at high government levels in several countries across the region. This strategy is accompanied by corporate social responsibility programs that fund initiatives promoting physical activity. These efforts, although appearing altruistic, are intended to improve the industry's public image and increase political influence in order to block regulations counter to their interests. If this industry wants to contribute to human well being, as it has publicly stated, it should avoid blocking legislative actions intended to regulate the marketing, advertising and sale of their products.

  3. Relation Between Higher Physical Activity and Public Transit Use

    Science.gov (United States)

    Vernez Moudon, Anne; Kang, Bumjoon; Hurvitz, Philip M.; Zhou, Chuan

    2014-01-01

    Objectives. We isolated physical activity attributable to transit use to examine issues of substitution between types of physical activity and potential confounding of transit-related walking with other walking. Methods. Physical activity and transit use data were collected in 2008 to 2009 from 693 Travel Assessment and Community study participants from King County, Washington, equipped with an accelerometer, a portable Global Positioning System, and a 7-day travel log. Physical activity was classified into transit- and non–transit-related walking and nonwalking time. Analyses compared physical activity by type between transit users and nonusers, between less and more frequent transit users, and between transit and nontransit days for transit users. Results. Transit users had more daily overall physical activity and more total walking than did nontransit users but did not differ on either non–transit-related walking or nonwalking physical activity. Most frequent transit users had more walking time than least frequent transit users. Higher physical activity levels for transit users were observed only on transit days, with 14.6 minutes (12.4 minutes when adjusted for demographics) of daily physical activity directly linked with transit use. Conclusions. Because transit use was directly related to higher physical activity, future research should examine whether substantive increases in transit access and use lead to more physical activity and related health improvements. PMID:24625142

  4. The synergy between mass-media and public management: a positive perspective for the Departments of Communication and Public Relations

    Directory of Open Access Journals (Sweden)

    Prodan (Mocanu Ana-Maria

    2012-12-01

    Full Text Available The aim of this article is to emphasize the major role the departments of communication and public relations detains in the synergy process between mass-media and public institutions, starting from a series of short-circuits which have occurred in Romanian public sector and led to the misunderstanding of messages, due to an unprofessional communication. Synergy, on its basic meaning, represents a simultaneous action oriented in the same direction, which involves several agents who have the same purposes (DEI, 1999. In the present context, I define synergy as intensifying two activities with a determinant role in the proper functioning of public management which contributes, to a large extent, on informing and educating the general public. The premises I start with are that crisis situations occur because of a faulty communication department and these could be avoided if there would be a permanent and efficient relationship between mass-media and public institutions. In other words, an efficiently organized department of communication could enhance company’s activity starting from the partnership between media and public institutions. Through collaboration, both units could present advantages to be felt at the organizational, social, economic and cultural levels.

  5. How to achieve public participation in nuclear waste decisions: Public relations or transparent adversary science

    International Nuclear Information System (INIS)

    Treichel, J.

    1999-01-01

    The current US nuclear waste disposal program began with passage of the Nuclear Waste Policy Act of 1982 and was modified by the Nuclear Waste Policy Amendments Act of 1987. The Amendments Act made many major changes to the original Act, the most significant of which was the singling out of Yucca Mountain as the only site to be studied for a deep geologic high-level nuclear waste repository. While that decision appeared to simplify and streamline the program, it vastly increased the levels of public resistance and protest, particularly in Nevada. To counter the lack of public acceptance of its programs, the Department of Energy has embarked on countless efforts purportedly aimed at creating public participation. However, nuclear proponents portray a Yucca Mountain repository as inevitable. With this a foregone conclusion, it is apparent to the public that opportunities for meaningful participation do not exist - the only allowable change is in their attitudes. This is purely paternalism and, as such, it is an insult to concerned citizens. Intelligent citizens believe that they cannot play a meaningful role in the current program. Their participation amounts to joining a game or contest that is rigged. All rules, regulations and standards governing the Yucca Mountain project are either changing or proposed to be changed. In a game of golf, players cannot determine their handicap midway through the course. While there are jokes told about such actions in sports, a nuclear waste policy is no laughing matter. In this case, the game, or site characterization program, is now referred to by many as 'advocacy science'. With Yucca Mountain as the only site, and the frantic cries of the commercial nuclear utilities that the lack of a disposal site is a national crisis, the investigations of the site appear to watchful citizens to be aimed at proving its suitability, rather than an objective study. Risk Assessment and risk communication, while very useful when applied

  6. How to achieve public participation in nuclear waste decisions: Public relations or transparent adversary science

    Energy Technology Data Exchange (ETDEWEB)

    Treichel, J. [Nevada Nuclear Waste Task Force, Las Vegas, NV (United States)

    1999-12-01

    The current US nuclear waste disposal program began with passage of the Nuclear Waste Policy Act of 1982 and was modified by the Nuclear Waste Policy Amendments Act of 1987. The Amendments Act made many major changes to the original Act, the most significant of which was the singling out of Yucca Mountain as the only site to be studied for a deep geologic high-level nuclear waste repository. While that decision appeared to simplify and streamline the program, it vastly increased the levels of public resistance and protest, particularly in Nevada. To counter the lack of public acceptance of its programs, the Department of Energy has embarked on countless efforts purportedly aimed at creating public participation. However, nuclear proponents portray a Yucca Mountain repository as inevitable. With this a foregone conclusion, it is apparent to the public that opportunities for meaningful participation do not exist - the only allowable change is in their attitudes. This is purely paternalism and, as such, it is an insult to concerned citizens. Intelligent citizens believe that they cannot play a meaningful role in the current program. Their participation amounts to joining a game or contest that is rigged. All rules, regulations and standards governing the Yucca Mountain project are either changing or proposed to be changed. In a game of golf, players cannot determine their handicap midway through the course. While there are jokes told about such actions in sports, a nuclear waste policy is no laughing matter. In this case, the game, or site characterization program, is now referred to by many as 'advocacy science'. With Yucca Mountain as the only site, and the frantic cries of the commercial nuclear utilities that the lack of a disposal site is a national crisis, the investigations of the site appear to watchful citizens to be aimed at proving its suitability, rather than an objective study. Risk Assessment and risk communication, while very useful when

  7. Implications for public health of the religiosity-longevity relation

    Directory of Open Access Journals (Sweden)

    Marcelo Saad

    Full Text Available Summary A growing body of scientific studies has demonstrated a consistently positive association between religious-spiritual (R/S involvement and beneficial effects on physical health, culminating with increased longevity. This protective effect on the mortality risk is not only statistically significant but also clinically relevant. The mechanisms involved in this association include psycho-neuro-endocrine-immune pathways, greater adherence to healthy behaviors and diverse social factors. Public health strategies could better explore this association. This can be done on an individual (health professionals adopting simple measures or institutional scale (health institutions joining religious organizations. Some evidence suggests that the benefits of R/S to health and longevity would be more present in populations from more religious regions. In this sense, the Americas (Latin and North are privileged places for the exploration of this association, compared to regions where there is certain indifference about R/S practices. Exploring this interface can improve the supply and usage of health care, especially for marginalized populations. To achieve this, health professionals, religious leaders and policy makers need to work together.

  8. Public goods in relation to competition, cooperation, and spite.

    Science.gov (United States)

    Levin, Simon A

    2014-07-22

    Public goods and common-pool resources are fundamental features of biological and social systems, and pose core challenges in achieving sustainability; for such situations, the immediate interests of individuals and the societies in which they are embedded are in potential conflict, involving game-theoretic considerations whose resolution need not serve the collective good. Evolution has often confronted such dilemmas--e.g., in bacterial biofilms--in the challenges of cancer, in nitrogen fixation and chelation, in the production of antibiotics, and in collective action problems across animal groups; there is much to learn from the Darwinian resolution of these situations for how to address problems our societies face today. Addressing these problems involves understanding the emergence of cooperative agreements, from reciprocal altruism and insurance arrangements to the social norms and more formal institutions that maintain societies. At the core are the issues of how individuals and societies discount the future and the interests of others, and the degree that individual decisions are influenced by regard for others. Ultimately, as Garrett Hardin suggested, the solution to problems of the commons is in "mutual coercion, mutually agreed upon," and hence in how groups of individuals form and how they arrive at decisions that ultimately benefit all.

  9. Implications for public health of the religiosity-longevity relation.

    Science.gov (United States)

    Saad, Marcelo; Medeiros, Roberta de

    2017-10-01

    A growing body of scientific studies has demonstrated a consistently positive association between religious-spiritual (R/S) involvement and beneficial effects on physical health, culminating with increased longevity. This protective effect on the mortality risk is not only statistically significant but also clinically relevant. The mechanisms involved in this association include psycho-neuro-endocrine-immune pathways, greater adherence to healthy behaviors and diverse social factors. Public health strategies could better explore this association. This can be done on an individual (health professionals adopting simple measures) or institutional scale (health institutions joining religious organizations). Some evidence suggests that the benefits of R/S to health and longevity would be more present in populations from more religious regions. In this sense, the Americas (Latin and North) are privileged places for the exploration of this association, compared to regions where there is certain indifference about R/S practices. Exploring this interface can improve the supply and usage of health care, especially for marginalized populations. To achieve this, health professionals, religious leaders and policy makers need to work together.

  10. Adoption of Social Media for Public Relations by Museums

    Directory of Open Access Journals (Sweden)

    Bojana Suzić

    2016-06-01

    Full Text Available Conceptual evolution of the Internet and Web, substantiated through Web 2.0 and the emergence of online social networks, reinvented the way that enterprises interact with their customers. Museums, as cultural institutions with an important mission, are not unaffected by that change, however. In order to fulfil their duties and societal purpose successfully, they have to attract visitors’ attention and engage the public effectively in a highly competitive and saturated environment. The goal of this paper is to analyze and compare the social media presence of museums in two European capitals. It focuses on museums in Prague and Berlin, and considers their general Web presence and the dynamics of activities on Facebook. In order to understand the integrative social media approach of museums in both regions, we investigated additionally Twitter and Youtube presence among museums with a Facebook account. The study reveals a lower presence of Prague museums both on the Web and in the identified social media networks, in comparison to Berlin museums. Moreover, we conclude that the presence of both regional museums on social media networks is low, while the integration and simultaneous application of more networks at the same time are negligible, both for Prague and Berlin museums.

  11. Cinema Spin: Exploring Film Depictions of Public Relations Practitioners

    Science.gov (United States)

    Lambert, Cheryl Ann

    2011-01-01

    Films have been used successfully to teach students about "the institutional and cultural role mass media play in creating, sustaining or changing social relations." They have also provided important lessons regarding ethical decision-making. This article presents an activity that enables students to understand the role of media and the concept of…

  12. Public Relations for Principals. "A Guidebook for the Pennsylvania Administrator."

    Science.gov (United States)

    Pennsylvania School Boards Association, Inc., Harrisburg.

    This report discusses what makes news, what people want to read, and how to write news releases or other informative bulletins and brochures. Also included are a description of principal-reporter-editor relations, some layout and typography data, and photography instructions. (JF)

  13. Public relation to possibility of atomic energetics development in Belarus

    International Nuclear Information System (INIS)

    Grusha, N.N.

    1996-01-01

    Results of sociological studies on the relation of various groups of population in Belarus to the problems of nuclear power development in the republic are given. The study showed that the the number of opponents and adherents of NPPs construction is practically equal. It is noted that the population is insufficiently informed on the nuclear power problem

  14. Review of Public Forestry Administrations and Related Institutions in ...

    African Journals Online (AJOL)

    The main findings of a study on forest administration and related institutional arrangements (PFA) are highlighted. The relevance and changing roles of PFA in Sub-Saharan African (SSA) countries are covered in the context of new paradigm for sustainable forest management (SFM). The current weak capacities and low ...

  15. Importance of public relations in recycling strategies: principles and case studies.

    Science.gov (United States)

    Salhofer, Stefan; Isaac, Nicole A

    2002-07-01

    The separate collection of waste, and especially of recyclables with specific collection systems, would not be possible without the involvement of the users. Apart from the physical installations such as collection containers, collection points, etc., the motivation of the users is an essential component. Motivation can be reinforced through public relations work. In addition to the underlying technical considerations, this paper describes the difference between communication in general and public relations and specifically examines public involvement in recycling. Through the use of examples, we look at the targeted users and typical media employed. Furthermore, we analyzes the development of public involvement. The examples show that public relations for recycling strategies relies to a great extent on attitudes, habits, and access to the target group. Thus, standardized procedures cannot be developed. For these reasons, public relation activities must be planned carefully and professionally and include an analysis of the target group, choice of media, and verification of success.

  16. The tetrapeptide Arg-Leu-Tyr-Glu inhibits VEGF-induced angiogenesis

    Energy Technology Data Exchange (ETDEWEB)

    Baek, Yi-Yong; Lee, Dong-Keon [Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, 200-702 (Korea, Republic of); So, Ju-Hoon; Kim, Cheol-Hee [Department of Biology, Chungnam National University, Daejeon, 305-764 (Korea, Republic of); Jeoung, Dooil [Department of Biochemistry, College of Natural Sciences, Kangwon National University, Chuncheon, Gangwon-do, 200-702 (Korea, Republic of); Lee, Hansoo [Department of Life Sciences, College of Natural Sciences, Kangwon National University, Chuncheon, Gangwon-do, 200-702 (Korea, Republic of); Choe, Jongseon [Department of Immunology, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, 200-702 (Korea, Republic of); Won, Moo-Ho [Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, 200-702 (Korea, Republic of); Ha, Kwon-Soo [Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, 200-702 (Korea, Republic of); Kwon, Young-Guen [Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, 120-752 (Korea, Republic of); Kim, Young-Myeong, E-mail: ymkim@kangwon.ac.kr [Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, 200-702 (Korea, Republic of)

    2015-08-07

    Kringle 5, derived from plasminogen, is highly capable of inhibiting angiogenesis. Here, we have designed and synthesized 10 tetrapeptides, based on the amino acid properties of the core tetrapeptide Lys-Leu-Tyr-Asp (KLYD) originating from anti-angiogenic kringle 5 of human plasminogen. Of these, Arg-Leu-Tyr-Glu (RLYE) effectively inhibited vascular endothelial growth factor (VEGF)-induced endothelial cell proliferation, migration and tube formation, with an IC{sub 50} of 0.06–0.08 nM, which was about ten-fold lower than that of the control peptide KLYD (0.79 nM), as well as suppressed developmental angiogenesis in a zebrafish model. Furthermore, this peptide effectively inhibited the cellular events that precede angiogenesis, such as ERK and eNOS phosphorylation and nitric oxide production, in endothelial cells stimulated with VEGF. Collectively, these data demonstrate that RLYE is a potent anti-angiogenic peptide that targets the VEGF signaling pathway. - Highlights: • The tetrapeptide RLYE inhibited VEGF-induced angiogenesis in vitro. • RLYE also suppressed neovascularization in a zebrafish model. • Its effect was correlated with inhibition of VEGF-induced ERK and eNOS activation. • RLYE may be used as a therapeutic drug for angiogenesis-related diseases.

  17. On the mathematical modeling of wound healing angiogenesis in skin as a reaction-transport process

    Directory of Open Access Journals (Sweden)

    Jennifer A Flegg

    2015-09-01

    Full Text Available Over the last thirty years, numerous research groups have attempted to provide mathematical descriptions of the skin wound healing process. The development of theoretical models of the interlinked processes that underlie the healing mechanism has yielded considerable insight into aspects of this critical phenomenon that remain difficult to investigate empirically. In particular, the mathematical modeling of angiogenesis, i.e. capillary sprout growth has offered new paradigms for the understanding of this highly complex and crucial step in the healing pathway. With the recent advances in imaging and cell tracking, the time is now ripe for an appraisal of the utility and importance of mathematical modeling in wound healing angiogenesis research. The purpose of this review is to pedagogically elucidate the conceptual principles that have underpinned the development of mathematical descriptions of wound healing angiogenesis, specifically those that have utilized a continuum reaction-transport framework, and highlight the contribution that such models have made towards the advancement of research in this field. We aim to draw attention to the common assumptions made when developing models of this nature, thereby bringing into focus the advantages and limitations of this approach. A deeper integration of mathematical modeling techniques into the practice of wound healing angiogenesis research promises new perspectives for advancing our knowledge in this area. To this end we detail several open problems related to the understanding of wound healing angiogenesis, and outline how these issues could be addressed through closer cross-disciplinary collaboration.

  18. On the mathematical modeling of wound healing angiogenesis in skin as a reaction-transport process.

    Science.gov (United States)

    Flegg, Jennifer A; Menon, Shakti N; Maini, Philip K; McElwain, D L Sean

    2015-01-01

    Over the last 30 years, numerous research groups have attempted to provide mathematical descriptions of the skin wound healing process. The development of theoretical models of the interlinked processes that underlie the healing mechanism has yielded considerable insight into aspects of this critical phenomenon that remain difficult to investigate empirically. In particular, the mathematical modeling of angiogenesis, i.e., capillary sprout growth, has offered new paradigms for the understanding of this highly complex and crucial step in the healing pathway. With the recent advances in imaging and cell tracking, the time is now ripe for an appraisal of the utility and importance of mathematical modeling in wound healing angiogenesis research. The purpose of this review is to pedagogically elucidate the conceptual principles that have underpinned the development of mathematical descriptions of wound healing angiogenesis, specifically those that have utilized a continuum reaction-transport framework, and highlight the contribution that such models have made toward the advancement of research in this field. We aim to draw attention to the common assumptions made when developing models of this nature, thereby bringing into focus the advantages and limitations of this approach. A deeper integration of mathematical modeling techniques into the practice of wound healing angiogenesis research promises new perspectives for advancing our knowledge in this area. To this end we detail several open problems related to the understanding of wound healing angiogenesis, and outline how these issues could be addressed through closer cross-disciplinary collaboration.

  19. Up-regulated basigin-2 in microglia induced by hypoxia promotes retinal angiogenesis.

    Science.gov (United States)

    Yin, Jie; Xu, Wen-Qin; Ye, Ming-Xiang; Zhang, Yong; Wang, Hai-Yan; Zhang, Jian; Li, Yu; Wang, Yu-Sheng

    2017-12-01

    Retinal microglia cells contribute to vascular angiogenesis and vasculopathy induced by relative hypoxia. However, its concrete molecular mechanisms in shaping retinal angiogenesis have not been elucidated. Basigin, being involved in tumour neovasculogenesis, is explored to exert positive effects on retinal angiogenesis induced by microglia. Therefore, we set out to investigate the expression of basigin using a well-characterized mouse model of oxygen-induced retinopathy, which recapitulated hypoxia-induced aberrant neovessel growth. Our results elucidate that basigin is overexpressed in microglia, which accumulating in retinal angiogenic sprouts. In vitro, conditioned media from microglia BV2 under hypoxia treatment increase migration and tube formation of retinal capillary endothelia cells, compared with media from normoxic condition. The angiogenic capacity of BV2 is inhibited after basigin knockdown by small interfering RNAs. A new molecular mechanism for high angiogenic capacity, whereby microglia cells release basigin via up-regulation of PI3K-AKT and IGF-1 pathway to induce angiogenesis is unveiled. Collectively, our results demonstrate that basigin from hypoxic microglia plays a pivotal pro-angiogenic role, providing new insights into microglia-promoting retinal angiogenesis. © 2017 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

  20. PROFESSIONALISM AND ETHICS: IS THE TOBACCO INDUSTRY DAMAGING THE HEALTH OF THE PUBLIC RELATIONS PROFESSION?

    Directory of Open Access Journals (Sweden)

    Adnan Hussein

    2006-01-01

    Full Text Available In most parts of the world, public relations (PR is seeking recognition as a profession. The path to gaining professional status hinges on its adherence to professional ethical standards. This paper argues that it is inappropriate for public relations practitioners to represent the tobacco industry because it is against the PR ethics of upholding truth and public interest. The paper cites historical tobacco industry documents to reveal that the industry would not hesitate to use unethical means to maximise profits.

  1. Seminar 'Dying forest and public relations work'

    Energy Technology Data Exchange (ETDEWEB)

    Glueck, P.

    1986-12-01

    The article on the seminar (Vienna, November 5, 1986) is divided into the following subject areas: 1) Public-relations work for problem solution and mobilization of co-citizens, 2) statements and activities of forestry-men in connection with dying forest, 3) use of organs of publication to fight dying forest, and 4) analysis and evaluation of the public-relations work done.

  2. OPTIMALISASI FUNGSI HUMAS PEMERINTAH THE OPTIMIZATION OF GOVERNMENT PUBLIC RELATIONS FUNCTION

    OpenAIRE

    Anwar Sani

    2014-01-01

    Abstract, world democratization forces many organizations including the government in this case, of all types in many regions of the world, to consider giving more attention to the government public relations activities. The role will include contributing to good governance and respect for human rights. That would mean public relations in Indonesia, as elsewhere in Asia, will be involved in the development of public diplomacy. Aware of the problems as well as the demands of optimization and r...

  3. [North-South relations in scientific publications: editorial racism?].

    Science.gov (United States)

    Victora, Cesar G; Moreira, Carmen B

    2006-08-01

    The aim of the present study was to comment on the possible existence of editorial prejudice among the editors of scientific journals from Northern countries against Southern authors. We highlight that a study using bibliometric methods documented an important imbalance in terms of the international scientific production of health researchers from high-income countries (the "North") and those from low and middle-income countries (the "South"). In a survey of Brazilian researchers, three in every four blamed this imbalance, at least in part, on prejudice among international editors. This is supported by the fact that a very small percentage of editorial board members of international journals come from the South. Although prejudice can explain part of the imbalance, there are also specific measures that may increase the likelihood of a paper from the South being accepted in international journals. These include the need to invest in the quality of the written text, and to show empathy with editors and readers, emphasizing the contribution of the manuscript to the international literature. Finally, we discuss whether research carried out in the South should be published in national or international journals, and suggest that there are at least six dimensions to this choice. These include language and target audience; type of contribution to knowledge; generalizability; citation index; speed of publication; and open access. The rapid growth in the number of Brazilian contributions to the international health literature shows that editorial prejudice, although often present, can be effectively offset by research with solid methodology and good-quality presentation.

  4. Public Relations: Ketchum brands new product with innovative PR strategy.

    Science.gov (United States)

    2006-01-01

    Novartis Pharmaceuticals tapped publis relations (PR) giant Ketchum earlier this year to spearhead a marketing campaign that would make its new U.S. Food and Drug Administration-approved prescription-based medication, Enablex, stand out among the crowd in over active bladder (OAB) treatment. OAB is a disorder that affects an estimated 33 million Americans making this treatment highly in demand with consumers and highly competitive with other pharmaceutical companies.

  5. Relations of power in public schools: a case study

    Directory of Open Access Journals (Sweden)

    Maria Custódia Jorge Rocha

    2014-04-01

    Full Text Available In this paper, based on a few authors who see power as a substantive element – instituted power – and others who consider it as an action verb – instituting power (ROCHA, 2007 –, highlighting some types of power relevant in sociological and organizational research on schools, we present empirical data and institutional discourses, enabled by a case study of qualitative nature. Thus, we can say that relations of power in schools both allow the strengthening of hierarchical and asymmetrical relations of power that exist between institutional players and enable the creation of new “circles of power” that can be promptly activated or can be object of a modernization process held in a more or less generalized manner. This may be reinforced and introduced to players/students, our main target of study, as the most legitimate object, superseding all others but not canceling them. The key objective is to present school organization as a highly complex environment, especially when considered in the light of the multiple and cumulative relations of power that emerge and are materialized.

  6. Genetic engineering in agriculture and corporate engineering in public debate: risk, public relations, and public debate over genetically modified crops.

    Science.gov (United States)

    Patel, Rajeev; Torres, Robert J; Rosset, Peter

    2005-01-01

    Corporations have long influenced environmental and occupational health in agriculture, doing a great deal of damage, making substantial profits, and shaping public debate to make it appear that environmental misfortunes are accidents of an otherwise well-functioning system, rather than systemic. The debate over the genetically modified (GM) crops is an example. The largest producer of commercial GM seeds, Monsanto, exemplifies the industry's strategies: the invocation of poor people as beneficiaries, characterization of opposition as technophobic or anti-progress, and portrayal of their products as environmentally beneficial in the absence of or despite the evidence. This strategy is endemic to contemporary market capitalism, with its incentives to companies to externalize health and environmental costs to increase profits.

  7. 48 CFR 2131.205-1 - Public relations and advertising costs.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Public relations and... REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Contracts With Commercial Organizations 2131.205-1 Public relations and advertising costs. The provisions of FAR 31.205-1 shall be modified to include the following...

  8. University Intervention into Community Issues as Dialogic Public Relations: A Case Study

    Science.gov (United States)

    Byrne, Jamie M.

    2007-01-01

    This paper examines a study of the wastewater collection and treatment issues of Little Rock and North Little Rock, Arkansas by University of Arkansas at Little Rock personnel and how it constitutes dialogic public relations. The paper defines dialogic public relations using Kent and Taylor's work and then uses their criteria to describe how this…

  9. An In-Depth Look at RACE: Creating a Public Relations Plan

    Science.gov (United States)

    Luttrell, Regina

    2013-01-01

    This article describes an activity in which students will understand, analyze, and apply the principles learned in the RACE process (research, action, communication, and evaluation). Students should have the ability to identify the four-step public relations planning process and ultimately create a public relations plan. This two-week activity is…

  10. Understanding and Using the Relationships between Business and Professional Communication and Public Relations

    Science.gov (United States)

    Penrose, John M.

    2015-01-01

    Aspects of research and pedagogy from the public relations discipline can benefit the business and professional communication instructor seeking new dimensions for the business and professional communication classroom. Elements of public relations (PR) found in Association for Business Communication articles and journals may be incorporated in the…

  11. An Evaluative Measure for Outputs in Student-Run Public Relations Firms and Applied Courses

    Science.gov (United States)

    Deemer, Rebecca A.

    2012-01-01

    A valid, reliable survey instrument was created to be used by public relations student-run firms and other applied public relations courses to gauge client satisfaction. A series of focus groups and pilot tests were conducted to ascertain themes, refine questions, and then to refine the entire instrument. Six constructs to be measured, including…

  12. Using Feature Films to Teach Public Relations: An Assessment Model from Nonmajor Students' Perspective

    Science.gov (United States)

    Mak, Angela Ka Ying; Hutton, James G.

    2014-01-01

    Teaching fundamental public relations courses to students from diverse backgrounds poses additional complexities in learning effectiveness. This exploratory study evaluated the effectiveness and identified the challenges of using films to teach public relations among nonmajor students. Results from an online survey and two focus groups found that…

  13. 48 CFR 1631.205-70 - FEHBP public relations and advertising costs.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true FEHBP public relations and... COST PRINCIPLES AND PROCEDURES Contracts With Commercial Organizations 1631.205-70 FEHBP public relations and advertising costs. (a) The cost of media messages that are directed at advising current FEHBP...

  14. Don't Shoot the Messenger: Public Relations for Law Enforcement

    Science.gov (United States)

    Baxter, David S.

    2013-01-01

    This communication project provides an overview of public relations as seen through the communication arts. It is specifically focused to give law enforcement officers a general review of the practice of public relations, communication basics, and an understanding of the media. This course also provides the facilitator with multiple tools for…

  15. NASA in Crisis: The Space Agency's Public Relations Efforts Regarding the Hubble Space Telescope.

    Science.gov (United States)

    Kauffman, James

    1997-01-01

    Examines the National Aeronautics and Space Administration's (NASA) public relations efforts concerning the Hubble telescope. Proposes that NASA's poor public relations exacerbated problems: NASA oversold the telescope before it was deployed, failed to develop a plan for release of images, provided misleading flight reports, and reported…

  16. Progress in Research and Theory: Eleven Years of International Public Relations Articles.

    Science.gov (United States)

    Coombs, W. Timothy

    Public relations has been caught up in the drive to internationalize business. Organizations are now dealing with global constituencies on a more frequent basis, which increases the demand for international public relations. One concern raised by this development is whether or not theory and research are keeping pace with the international needs…

  17. The Uniting of a Profession: The History of Public Relations Organizations.

    Science.gov (United States)

    Schoch, Kathleen S.

    A chronological history of major public relations organizations in the United States is presented in this paper. Following an overview of the public relations profession, the paper traces the development of several sporatically formed organizations, starting with the Financial Advertising Association in 1915, and leading to the largest…

  18. Incorporating Global/Multicultural Perspectives in Public Relations Education: An Ethnographic Account.

    Science.gov (United States)

    Bardhan, Nilanjana

    This paper points out that in public relations (PR) the global network approach is fast catching on along with the trend of opening subsidiary offices and entering joint ventures and affiliations with PR agencies in various parts of the world. The paper discusses the need to build theory in the area of international public relations so that…

  19. Applying Classical Ethical Theories to Ethical Decision Making in Public Relations: Perrier's Product Recall.

    Science.gov (United States)

    Pratt, Cornelius B.

    1994-01-01

    Links ethical theories to the management of the product recall of the Perrier Group of America. Argues for a nonsituational theory-based eclectic approach to ethics in public relations to enable public relations practitioners, as strategic communication managers, to respond effectively to potentially unethical organizational actions. (SR)

  20. Journalists' and Public Relations Practitioners' News Values: Perceptions and Cross-Perceptions.

    Science.gov (United States)

    Sallot, Lynne M.; Steinfatt, Thomas M.; Salwen, Michael B.

    1998-01-01

    Contributes to research on the relationship between journalism and public relations by surveying journalists and public relations practitioners. Shows that the two groups share generally similar news values, but that journalists were largely unaware of this similarity. Finds that practitioners, expecting contributions of social good by public…

  1. The New Rules of PR and Marketing: A Teaching Unit for College Public Relations Programs

    Science.gov (United States)

    Mauldin, Candice

    2011-01-01

    The purpose of this lesson plan is to introduce the importance of social media and the Internet on public relations and marketing. The lesson describes the new rules for public relations versus the old rules. It is a more in depth look at how, and why, to use blogging, social media, and the Internet for promoting a company and appealing to buyers.…

  2. Hippocrates and Bernays: A Medical Ethics Perspective on the Ethics of Public Relations.

    Science.gov (United States)

    Kruckeberg, Dean

    While comparisons of public relations practitioners and attorneys remain attractive among practitioners and scholars searching for evidence of public relation's emergence as a profession, practitioners would be better served by emulating physicians in their "healing" role rather than attorneys in their "advocacy" role. Public…

  3. Interpreting Definitions of Public Relations: Self Assessment and a Symbolic Interactionism-Based Alternative.

    Science.gov (United States)

    Gordon, Joye C.

    1997-01-01

    Reviews several popular definitions of public relations; explicates the shared elements and assumptions inherent in these definitions. Presents an alternative conceptualization of public relations based upon Herbert Blumer's symbolic interactionism. Looks to stimulate questioning and self assessment and to introduce alternative goals, ideas, and…

  4. Ethics in Strategic Communication Campaigns: The Case for a New Approach to Public Relations.

    Science.gov (United States)

    Botan, Carl

    1997-01-01

    Uses the example of public relations to describe important distinctions between monologic and dialogic campaigns. Explains why the dominant monological approach to public relations has long been recognized as "ethically paralyzed." Suggests an ethically more viable dialogic approach. Discusses reasons the business community has been slow to adopt…

  5. A Tribute to Scott M. Cutlip: Father of Public Relations Education.

    Science.gov (United States)

    Wright, Donald K.

    1991-01-01

    Reviews the academic career of Scott Cutlip and his impact on public relations education. Considers that his work (with its emphasis on applied social and behavioral research, and ethics) made public relations an art and science that analyzes trends, predicts their consequences, and counsels organizations about planning and implementing…

  6. Pengaruh Marketing Public Relation Terhadap Loyalitas Pelanggan Pada PT. Jalur Nugraha Ekakurir (JNE Bandung

    Directory of Open Access Journals (Sweden)

    Taufiq Hidayat

    2015-10-01

    Full Text Available The purpose of this study to determine the relationship and influence of Marketing and Public Relations on customer loyalty JNE Bandung branch. The method used is quantitative research methods. The model study was conducted by the method of explanation or correlation method. The number of respondents 45 people with random sampling techniques. The coefficient of determination of the role of marketing public relations to customer loyalty 56.55% showed marked positive correlation coefficients that describe the direction of positive effects as well, by the better Marketing Public Relations (X is carried out, then the effect on customer loyalty (Y which formed. The coefficient of determination of the role of marketing public relations to customer loyalty is equal to 0.5655. The value of 56.55% indicates that customer loyalty is influenced by the role of Marketing and Public Relations, while the remaining 43.45% is determined by other factors outside of the study.

  7. How Does Car Parking Availability and Public Transport Accessibility Influence Work-Related Travel Behaviors?

    Directory of Open Access Journals (Sweden)

    Grant M. Schofield

    2010-02-01

    Full Text Available This study investigated the relationships between car parking, public transport, travel behaviors, and health outcomes for adults (n = 1,188 traveling to a worksite. Public transport was used for 12.1% of the work-related commute. Those who had higher levels of walking, no worksite car park access, lived proximal to a public transport stop, had limited automobile availability, traveled to the main business district, perceived public transport as accessible, or did not have company car access were more likely to use public transportation. Accordingly, proximal residential transit stops and restrictions for company car accessibility and parking at the worksite are needed.

  8. Halting angiogenesis by non-viral somatic gene therapy alleviates psoriasis and murine psoriasiform skin lesions

    DEFF Research Database (Denmark)

    Zibert, John Robert; Wallbrecht, Katrin; Schön, Margarete

    2011-01-01

    with epidermal expression of human TGF-ß1, we have demonstrated that antiangiogenic non-viral somatic gene therapy reduces the cutaneous microvasculature and alleviates chronic inflammatory skin disorders. Transient muscular expression of the recombinant disintegrin domain (RDD) of metargidin (also known as ADAM...... in all models. Thus, non-viral antiangiogenic gene therapy can alleviate psoriasis and may do so in other angiogenesis-related inflammatory skin disorders.......-15) by in vivo electroporation reduced cutaneous angiogenesis and vascularization in all 3 models. As demonstrated using red fluorescent protein-coupled RDD, the treatment resulted in muscular expression of the gene product and its deposition within the cutaneous hyperangiogenic connective tissue...

  9. How to reduce emissions related to consumption: which public policies?

    International Nuclear Information System (INIS)

    Fink, Meike; Gautier, Celia

    2014-05-01

    This report proposes an assessment of greenhouse gas emissions related to consumption in the world. It examines which are currently the world emission flows which come with trade exchanges (intermediate and final goods) between countries. The first part tries to highlight hidden emissions present in our imports and exports. It presents the different methods of greenhouse gas accounting, discusses the emission flows at the planet level, and the challenge of the limitation of 'carbon leaks', and discusses what makes a country a net emission importer or exporter. The second part discusses how France can reduce its consumption-based emissions, how to reach a factor 4 of reduction on these emissions, how to act against leaks and inflows of emissions through measures at the world level (international agreement, reduction of emissions by sea and air transport, reduction of industry emissions) or at the national level (relocation of polluting industries in France or Europe, promotion of short circuits, eco-design, changes in consumption modes, measures on groups of products which import emissions)

  10. WNT Signaling Is Required for Peritoneal Membrane Angiogenesis.

    Science.gov (United States)

    Padwal, Manreet Kaur; Cheng, Genyang; Liu, Limin; Boivin, Felix J; Gangji, Azim; Brimble, Kenneth Scott; Bridgewater, Darren; Margetts, Peter J

    2018-01-24

    The WNT signaling pathway is involved in wound healing and fibrosis. We evaluated the WNT signaling pathway in peritoneal membrane injury. We assessed WNT1 protein expression in the peritoneal effluents of 54 stable peritoneal dialysis (PD) patients and WNT-related gene expression in ex vivo mesothelial cell cultures from 21 PD patients. In a transforming growth factor beta (TGFB) mediated animal model of peritoneal fibrosis, we evaluated regulation of the WNT pathway and the effect of WNT inhibition on peritoneal fibrosis and angiogenesis. WNT1 and WNT2 gene expression were positively correlated with peritoneal membrane solute transport in PD patients. In the mouse peritoneum, TGFΒ-induced peritoneal fibrosis was associated with increased expression of WNT2 and WNT4. Peritoneal b-catenin protein was significantly upregulated after infection with AdTGFB along with elements of the WNT signaling pathway. Treatment with a b-catenin inhibitor (ICG-001) in mice with AdTGFB-induced peritoneal fibrosis resulted in attenuation of peritoneal angiogenesis and reduced vascular endothelial growth factor. Similar results were also observed with the WNT antagonist Dickkopf related protein (DKK) 1. In addition to this, DKK-1 blocked epithelial to mesenchymal transition and increased levels of the cell adhesion protein E-cadherin. We provide evidence that WNT signaling is active in the setting of experimental peritoneal fibrosis and WNT1 correlates with patient peritoneal membrane solute transport in PD patients. Intervention in this pathway is a possible therapy for peritoneal membrane injury.

  11. Cytokines and Angiogenesis in the Corpus Luteum

    Directory of Open Access Journals (Sweden)

    António M. Galvão

    2013-01-01

    Full Text Available In adults, physiological angiogenesis is a rare event, with few exceptions as the vasculogenesis needed for tissue growth and function in female reproductive organs. Particularly in the corpus luteum (CL, regulation of angiogenic process seems to be tightly controlled by opposite actions resultant from the balance between pro- and antiangiogenic factors. It is the extremely rapid sequence of events that determines the dramatic changes on vascular and nonvascular structures, qualifying the CL as a great model for angiogenesis studies. Using the mare CL as a model, reports on locally produced cytokines, such as tumor necrosis factor α (TNF, interferon gamma (IFNG, or Fas ligand (FASL, pointed out their role on angiogenic activity modulation throughout the luteal phase. Thus, the main purpose of this review is to highlight the interaction between immune, endothelial, and luteal steroidogenic cells, regarding vascular dynamics/changes during establishment and regression of the equine CL.

  12. Trisubstituted pyrazolopyrimidines as novel angiogenesis inhibitors.

    Directory of Open Access Journals (Sweden)

    Sabine B Weitensteiner

    Full Text Available Current inhibitors of angiogenesis comprise either therapeutic antibodies (e.g. bevacicumab binding to VEGF-A or small molecular inhibitors of receptor tyrosin kinases like e.g. sunitinib, which inhibits PDGFR and VEGFR. We have recently identified cyclin-dependent kinase 5 (Cdk5 as novel alternative and pharmacologically accessible target in the context of angiogenesis. In the present work we demonstrate that trisubstituted pyrazolo[4,3-d]pyrimidines constitute a novel class of compounds which potently inhibit angiogenesis. All seven tested compounds inhibited endothelial cell proliferation with IC(50 values between 1 and 18 µM. Interestingly, this seems not to be due to cytotoxicity, since none of them showed acute cytotoxic effects on endothelial cells at a concentration of 10 µM,. The three most potent compounds (LGR1404, LGR1406 and LGR1407 also inhibited cell migration (by 27, 51 and 31%, resp., chemotaxis (by 50, 70 and 60% in accumulative distance, resp., and tube formation (by 25, 60 and 30% of total tube length, resp. at the non-toxic concentration of 10 µM. Furthermore, angiogenesis was reduced in vivo in the CAM assay by these three compounds. A kinase selectivity profiling revealed that the compounds prevalently inhibit Cdk2, Cdk5 and Cdk9. The phenotype of the migrating cells (reduced formation of lamellipodia, loss of Rac-1 translocation to the membrane resembles the previously described effects of silencing of Cdk5 in endothelial cells. We conclude that especially LGR1406 and LGR1407 are highly attractive anti-angiogenic compounds, whose effects seem to largely depend on their Cdk5 inhibiting properties.

  13. Wars2 is a determinant of angiogenesis

    Czech Academy of Sciences Publication Activity Database

    Wang, M.; Sips, P.; Khin, E.; Rotival, M.; Sun, X.; Ahmed, R.; Widjaja, A. A.; Schafer, S.; Yusoff, P.; Choksi, P. K.; Ko, N. S. J.; Singh, M. K.; Epstein, D.; Guan, Y.; Houštěk, Josef; Mráček, Tomáš; Nůsková, Hana; Mikell, B.; Tan, J.; Pesce, F.; Kolář, František; Bottolo, L.; Mancini, M.; Hubner, N.; Pravenec, Michal; Petretto, E.; MacRae, C.; Cook, S. A.

    2016-01-01

    Roč. 7, Jul (2016), s. 12061 ISSN 2041-1723 R&D Projects: GA MŠk(CZ) LL1204; GA ČR(CZ) GB14-36804G; GA MZd(CZ) NT12370 Institutional support: RVO:67985823 Keywords : Wars2 mutant gene * angiogenesis * coronary flow * spontaneously hypertensive rat Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 12.124, year: 2016

  14. Proton pumps, angiogenesis, and metastatic breast cancer

    Science.gov (United States)

    Rojas, Jose D.; Sanka, Shankar C.; Luo, Defeng; Busch, Christian; Martinez, Gloria M.; Hendrix, Mary J. C.; Martinez-Zaguilan, Raul

    2000-04-01

    We have previously shown the relationship between metastatic potential and plasmalemmal V-H+-ATPase (pmV-ATPase) expression in tumor cells. This led us to hypothesize that pmV-ATPase activity is involved in invasion. Angiogenesis involves invasion of adjacent tissues by microvascular endothelial cells, thus we hypothesized that pmV-ATPases contribute to pHin regulation and invasion in microvascular endothelial cells.

  15. What do decision makers learn from public forums on climate-related hazards and resilience?

    Science.gov (United States)

    Weller, N.; Farooque, M.; Sittenfeld, D.

    2017-12-01

    Public engagement around climate resilience efforts can foster learning for both public audiences and decision makers. On the one hand, public audiences learn about environmental hazards and strategies to increase community resilience through effective public engagement. On the other, decision makers and scientists learn about community members' values and priorities and their relation to environmental hazards and resilience strategies. Evidence from other public engagement efforts involving decision makers suggests that decision maker involvement results in reflection by officials on their own values, capacities, and roles. However, few public engagement exercises evaluate impacts on decision makers. As part of the Science Center Public Forums project, which aims to conduct public forums in eight cities across the country on resiliency to drought, heat, extreme precipitation, and sea level rise, we sought to 1) build partnerships with local decision makers and scientists around public forums and 2) explore how decision makers and scientists interacted with the planning and undertaking of those public forums. We held workshops with decision makers and scientists to inform forum content and identify local resilience issues. We will conduct interviews with local decision makers regarding their involvement in forum planning, their reflections and takeaways from the forum itself, and their perspectives on the value of public engagement for policy making. We will present our model of engagement with decision makers, initial findings from interviews, and lessons learned from connecting decision makers and scientists to public engagement efforts.

  16. Soy and Breast Cancer: Focus on Angiogenesis

    Directory of Open Access Journals (Sweden)

    Lenka Varinska

    2015-05-01

    Full Text Available Epidemiological studies have revealed that high consumption of soy products is associated with low incidences of hormone-dependent cancers, including breast and prostate cancer. Soybeans contain large amounts of isoflavones, such as the genistein and daidzain. Previously, it has been demonstrated that genistein, one of the predominant soy isoflavones, can inhibit several steps involved in carcinogenesis. It is suggested that genistein possesses pleiotropic molecular mechanisms of action including inhibition of tyrosine kinases, DNA topoisomerase II, 5α-reductase, galectin-induced G2/M arrest, protein histidine kinase, and cyclin-dependent kinases, modulation of different signaling pathways associated with the growth of cancer cells (e.g., NF-κB, Akt, MAPK, etc. Moreover, genistein is also a potent inhibitor of angiogenesis. Uncontrolled angiogenesis is considered as a key step in cancer growth, invasion, and metastasis. Genistein was found to inhibit angiogenesis through regulation of multiple pathways, such as regulation of VEGF, MMPs, EGFR expressions and NF-κB, PI3-K/Akt, ERK1/2 signaling pathways, thereby causing strong antiangiogenic effects. This review focuses on the antiangiogenic properties of soy isoflavonoids and examines their possible underlying mechanisms.

  17. Tissue factor in cancer progression and angiogenesis.

    Science.gov (United States)

    Ruf, Wolfram; Yokota, Naho; Schaffner, Florence

    2010-04-01

    Constitutive expression of tissue factor (TF) by cancer cells triggers local and systemic activation of the coagulation cascade and is a major cause of cancer-associated thrombosis. Primary breast cancer biopsies show a marked upregulation of TF and protease activated receptor (PAR) 2, as well as increased TF cytoplasmic domain phosphorylation that is correlated with cancer relapse. TF signaling involving PAR2 and integrins has multiple effects on angiogenesis and tumor progression. The non-coagulant, alternatively spliced form of TF retains an integrin-binding site and, upon deposition into the tumor stroma, stimulates angiogenesis by ligating endothelial integrins alpha(v)beta(3) and alpha(6)beta(1). On tumor cells, full-length TF is constitutively associated with laminin-binding beta(1) integrins that support TF-VIIa-PAR2 signaling leading to upregulation of pro-angiogenic and immune modulatory cytokines and growth factors. Deficiency of PAR2, but not of the thrombin receptor PAR1, delays spontaneous breast cancer development and the angiogenic switch in mice. In addition, human xenograft breast cancer growth and angiogenesis is suppressed by selective antibody inhibition of TF-VIIa-PAR2 signaling, but not by blocking TF initiated coagulation. Thus, interruption of TF signaling represents a potential anti-angiogenic strategy that does not carry an increased risk of bleeding associated with prolonged inhibition of the TF coagulation pathway.

  18. Informing public health policy through deliberative public engagement: perceived impact on participants and citizen-government relations.

    Science.gov (United States)

    Molster, Caron; Potts, Ayla; McNamara, Beverley; Youngs, Leanne; Maxwell, Susannah; Dawkins, Hugh; O'Leary, Peter

    2013-09-01

    Deliberative public engagement has been proposed for policy development, where issues are complex and there are diverse public perspectives and low awareness of competing issues. Scholars suggest a range of potential outcomes for citizens and government agencies from involvement in such processes. Few studies have examined outcomes from the perspective of citizen participants in deliberative processes. To examine participant perceptions of their involvement in and outcomes of a deliberative engagement exercise. A case study using semistructured interviews was conducted with participants following a deliberative forum on biobanking. From their involvement in the deliberative exercise, participants described transformations in their knowledge and beliefs about the policy issues. They reported being more informed to the extent of having confidence to educate others and effectively contribute to public policy development. They had developed greater trust in government policymakers who they believed would take reasonable account of their recommendations. We conclude that the participants were satisfied with the outcomes of the deliberative public engagement process and viewed it as an effective means of citizen involvement in public policy development. Particularly for citizens who participate in deliberative processes, such processes may promote active citizenship, empower citizens to undertake representative and educative roles, and improve relations between citizens and government agencies. Actions taken by policymakers subsequent to the deliberative exercise, whereby the majority of citizen recommendations were incorporated in the policy developed, may have contributed to participants holding sustained levels of trust in the commissioning government agency.

  19. Strategi Marketing Public Relations Dalam Menarik Minat Pelanggan Di Hotel Grand Elite Pekanbaru

    OpenAIRE

    Wati, Triyani Merdeka; Wirman, Welly

    2016-01-01

    Service accomodate, eat and drink, and also the other service. With the increasing development of four stars hotel in Pekanbaru, much less affected Grand Elite Hotel to build a strategy to attract costumer interest. The problem identification in this research is on how the Marketing Public Relations strategy using publication, events, information news, and public service activity to attract costumer interest in Grand Elite Hotel Pekanbaru. This research done by the qualitatif research method ...

  20. Linking public relations processes and organizational effectiveness at a state health department.

    Science.gov (United States)

    Wise, Kurt

    2003-01-01

    This qualitative case study explored a state health department's relationships with strategic constituencies from a public relations perspective. The relationships were explored within the theoretical framework of the Excellence Theory, the dominant paradigm in public research. Findings indicate application of the Excellence Theory has the potential to increase organizational effectiveness at public health entities. With respect to the case investigated, findings indicate that the state health department could increase its organizational effectiveness through the adoption of recommendations based on the Excellence Theory.

  1. Putting All One's Eggs in One Basket: Relational Contracts and the Provision of Local Public Services

    OpenAIRE

    Claudine Desrieux; Eshien Chong; Stéphane Saussier

    2010-01-01

    The provision of local public services is increasingly being contracted out to private companies. We observe that local governments regularly choose the same private operator for a range of different services, and develop a model of relational contracts that shows how this strategy may lead to better performance at lower cost for public authorities. We test the implication of our model using an original database of the contractual choices made by 5000 French local public authorities in the ye...

  2. Therapeutic angiogenesis due to balanced single-vector delivery of VEGF and PDGF-BB

    Science.gov (United States)

    Banfi, Andrea; von Degenfeld, Georges; Gianni-Barrera, Roberto; Reginato, Silvia; Merchant, Milton J.; McDonald, Donald M.; Blau, Helen M.

    2012-01-01

    Therapeutic angiogenesis by delivery of vascular growth factors is an attractive strategy for treating debilitating occlusive vascular diseases, yet clinical trials have thus far failed to show efficacy. As a result, limb amputation remains a common outcome for muscle ischemia due to severe atherosclerotic disease, with an overall incidence of 100 per million people in the United States per year. A challenge has been that the angiogenic master regulator vascular endothelial growth factor (VEGF) induces dysfunctional vessels, if expressed outside of a narrow dosage window. We tested the hypothesis that codelivery of platelet-derived growth factor-BB (PDGF-BB), which recruits pericytes, could induce normal angiogenesis in skeletal muscle irrespective of VEGF levels. Coexpression of VEGF and PDGF-BB encoded by separate vectors in different cells or in the same cells only partially corrected aberrant angiogenesis. In marked contrast, coexpression of both factors in every cell at a fixed relative level via a single bicistronic vector led to robust, uniformly normal angiogenesis, even when VEGF expression was high and heterogeneous. Notably, in an ischemic hindlimb model, single-vector expression led to efficient growth of collateral arteries, revascularization, increased blood flow, and reduced tissue damage. Furthermore, these results were confirmed in a clinically applicable gene therapy approach by adenoviral-mediated delivery of the bicistronic vector. We conclude that coordinated expression of VEGF and PDGF-BB via a single vector constitutes a novel strategy for harnessing the potency of VEGF to induce safe and efficacious angiogenesis.—Banfi, A., von Degenfeld, G., Gianni-Barrera, R., Reginato, S., Merchant, M. J., McDonald, D. M., Blau, H. M. Therapeutic angiogenesis due to balanced single-vector delivery of VEGF and PDGF-BB. PMID:22391130

  3. Ethyl p-methoxycinnamate from Kaempferia galanga inhibits angiogenesis through tyrosine kinase

    Directory of Open Access Journals (Sweden)

    Juni Ekowati

    2015-04-01

    Full Text Available Background Many tumors express on their receptor tyrosine kinases vascular endothelial growth factor activity associated with angiogenesis. Inhibition of angiogenesis through reduction of tyrosine kinase activity is a promising strategy for cancer therapy. The present study aimed to determine the mechanism and potency of ethyl p-methoxycinnamate (EPMC isolated from Kaempferia galanga as angiogenesis inhibitor. Methods A laboratory experimental study was conducted using chorio-allantoic membranes (CAMs of nine-day old chicken eggs induced by 60ng basic fibroblast growth factor (bFGF. Ethyl p-methoxycinnamate (EPMC potency was determined at dosages of 30, 60, 90 and 120 mg and compared with celecoxib 60 mg as reference drug and one negative bFGF-induced control group. Neovascularization and endothelial cell count in CAM blood vessels were evaluated. To predict the antiangiogenic mechanism of EPMC, a docking study was performed with the Molegro Virtual Docker program on tyrosine kinase as receptor (PDB 1XKK. Results Angiogenesis stimulation by bFGF was prevented significantly (p<0.05 by EPMC at dosages of 30, 60, 90 and 120 mg and this activity was dose dependent. Molecular docking showed interaction between EPMC functional groups and tyrosine kinase amino acids at Met766, Met793, Thr854, Thr790, Gln791 and Ala743. There was an association between EPMC antiangiogenic activity and docking study results. Conclusions Ethyl p-methoxycinnamate is a potential new angiogenesis inhibitor through interaction with tyrosine kinase. EPMC could be a promising therapeutic agent for treatment of angiogenesis-related diseases.

  4. Angiogenesis in salivary gland tumors: from clinical significance to treatment.

    Science.gov (United States)

    Theocharis, Stamatios; Gribilas, George; Giaginis, Constantinos; Patsouris, Efstratios; Klijanienko, Jerzy

    2015-06-01

    Salivary gland tumors (SGTs) represent a rare cancer entity, consisting of various morphological features that complicate diagnosis. Their diversity in terms of morphology and clinical course makes defining risk factors difficult, while the molecular steps responsible for SGT development remain unclear. Angiogenesis, a hallmark of cancer development, is considered as an attractive target. This review aims to summarize the available research regarding angiogenesis in SGTs from clinical significance to treatment options. The available data suggest that microvessel density (MVD) evaluation may be capable of discriminating between benign and malignant SGTs, while the use of CD105 antibody seems to be the most suitable. Substantial evidence also suggests that MVD and VEGF expression could be used as prognostic factors in malignant SGTs. Although several agents have shown antiangiogenic activities in adenoid cystic carcinoma cells and xenograft tumors, limited effectiveness in the existing clinical trials was noted. Further studies are strongly recommended for the validation of already well-known and the identification of novel prognostic and predictive angiogenic markers. There is also a strong demand for relatively larger cohorts, homogenous samples referring to same histological SGT subtypes and including an equivalent number of low- and high-grade SGTs.

  5. Humor in High School and the Role of Teacher Leaders in School Public Relations

    Science.gov (United States)

    Kosiczky, Bonnie; Mullen, Carol A.

    2013-01-01

    How can public schools improve public relations strategies, particularly in communications between teachers and students? The purposes of this study were to investigate teacher leaders' perceptions of the use of humor in the high school classroom and discover how humor might bridge instruction to student learning and strengthen teacher-student…

  6. Engaging Communities through Vision Development: A Systems Approach to Public Relations

    Science.gov (United States)

    Chance, Patty L.

    2005-01-01

    The implementation of No Child Left Behind (NCLB) federal legislation in 2001 exemplifies extreme reaction to an escalating public unrest with educational systems over the past several decades of "educational reform." Effective public relations and communication with stakeholders is threatened during this time of increased public…

  7. The Field Experience: The Unique Aspect of a Public Relations Program.

    Science.gov (United States)

    Meussling, Vonne

    Reporting on a public relations course at Indiana State University, this paper presents specific guidelines for students to use in converting the classroom theory of creative problem solving, persuasion, promotion, publicity, and management into the actual staging of a special event and/or fund raising. The paper offers suggestions in the areas of…

  8. Toastmaster's Inspired Pedagogical Changes: From a Speech Class into a Public Relations Course

    Science.gov (United States)

    Shadinger, David

    2016-01-01

    Action research is used to view pedagogical changes, first in a speech class and then in a public relations course over a five-year period. The course instructor gained experience as a member of a Toastmasters International club and used Toastmasters-like activities, to revise content in the courses. Ultimately, students in the public relations…

  9. Opportunity to Improve Public Perceptions of Arthropods and Arthropod-Related Benefits

    Science.gov (United States)

    Harris, Bethany A.; Braman, S. Kristine

    2016-01-01

    The general public may not recognize the value of conserving insects and spiders in home landscapes. We surveyed individuals to assess public perceptions of 10 arthropods--nine common insects and one common spider species--and to determine whether arthropod-related attitudes could be altered. Additionally, we collected data on survey respondent…

  10. Local inhibition of angiogenesis by halofuginone coated silicone materials.

    Science.gov (United States)

    Jordan, Martin C; Zeplin, Philip H

    2012-05-01

    Anti-angiogenic therapy is a promising approach for the treatment of increased angiogenesis in certain diseases. We aimed to investigate the local anti-angiogenic effect of silicone implants coated with Halofuginone, an angiogenesis inhibitor that inhibits synthesis of collagen-type-I and matrix metalloproteinases. The degree of angiogenesis was observed after implantation of surface modified Halofuginone eluting silicone implants into a submuscular pocket in rats over a period of 3 months. Subsequently, key mediators of angiogenesis (TGF-beta-1, bFGF, COL1A1, MMP-2, MMP-9, VEGF and PDGF) were established by immunohistological staining and RT-PCR and statistically evaluated. In comparison to uncoated silicone implants, Halofuginone eluting silicone implants lead to a significant local decrease of angiogenesis. Halofuginone eluting hybrid surface silicone implants have a significant local anti-angiogenic effect by down-regulating the expression activity of key mediators of angiogenesis.

  11. Disruption of Angiogenesis by Anthocyanin-Rich Extracts of Hibiscus sabdariffa

    Science.gov (United States)

    Joshua, Madu; Okere, Christiana; Sylvester, O’Donnell; Yahaya, Muhammad; Precious, Omale; Dluya, Thagriki; Um, Ji-Yeon; Neksumi, Musa; Boyd, Jessica; Vincent-Tyndall, Jennifer; Choo, Dong-Won; Gutsaeva, Diana R.; Jahng, Wan Jin

    2017-01-01

    Abnormal vessel formations contribute to the progression of specific angiogenic diseases including age-related macular degeneration. Adequate vessel growth and maintenance represent the coordinated process of endothelial cell proliferation, matrix remodeling, and differentiation. However, the molecular mechanism of the proper balance between angiogenic activators and inhibitors remains elusive. In addition, quantitative analysis of vessel formation has been challenging due to complex angiogenic morphology. We hypothesized that conjugated double bond containing-natural products, including anthocyanin extracts from Hibiscus sabdariffa, may control the proper angiogenesis. The current study was designed to determine whether natural molecules from African plant library modulate angiogenesis. Further, we questioned how the proper balance of anti- or pro-angiogenic signaling can be obtained in the vascular microenvironment by treating anthocyanin or fatty acids using chick chorioallantoic membrane angiogenesis model in ovo. The angiogenic morphology was analyzed systematically by measuring twenty one angiogenic indexes using Angiogenic Analyzer software. Chick chorioallantoic model demonstrated that anthocyanin-rich extracts inhibited angiogenesis in time- and concentration-dependent manner. Molecular modeling analysis proposed that hibiscetin as a component in Hibiscus may bind to the active site of vascular endothelial growth factor receptor 2 (VEGFR2) with ΔG= −8.42 kcal/mol of binding energy. Our results provided the evidence that anthocyanin is an angiogenic modulator that can be used to treat uncontrolled neovascular-related diseases, including age-related macular degeneration. PMID:28459020

  12. Disruption of Angiogenesis by Anthocyanin-Rich Extracts of Hibiscus sabdariffa.

    Science.gov (United States)

    Joshua, Madu; Okere, Christiana; Sylvester, O'Donnell; Yahaya, Muhammad; Precious, Omale; Dluya, Thagriki; Um, Ji-Yeon; Neksumi, Musa; Boyd, Jessica; Vincent-Tyndall, Jennifer; Choo, Dong-Won; Gutsaeva, Diana R; Jahng, Wan Jin

    2017-02-01

    Abnormal vessel formations contribute to the progression of specific angiogenic diseases including age-related macular degeneration. Adequate vessel growth and maintenance represent the coordinated process of endothelial cell proliferation, matrix remodeling, and differentiation. However, the molecular mechanism of the proper balance between angiogenic activators and inhibitors remains elusive. In addition, quantitative analysis of vessel formation has been challenging due to complex angiogenic morphology. We hypothesized that conjugated double bond containing-natural products, including anthocyanin extracts from Hibiscus sabdariffa , may control the proper angiogenesis. The current study was designed to determine whether natural molecules from African plant library modulate angiogenesis. Further, we questioned how the proper balance of anti- or pro-angiogenic signaling can be obtained in the vascular microenvironment by treating anthocyanin or fatty acids using chick chorioallantoic membrane angiogenesis model in ovo. The angiogenic morphology was analyzed systematically by measuring twenty one angiogenic indexes using Angiogenic Analyzer software. Chick chorioallantoic model demonstrated that anthocyanin-rich extracts inhibited angiogenesis in time- and concentration-dependent manner. Molecular modeling analysis proposed that hibiscetin as a component in Hibiscus may bind to the active site of vascular endothelial growth factor receptor 2 (VEGFR2) with ΔG= -8.42 kcal/mol of binding energy. Our results provided the evidence that anthocyanin is an angiogenic modulator that can be used to treat uncontrolled neovascular-related diseases, including age-related macular degeneration.

  13. 76 FR 31632 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2011-06-01

    ... Step Up Ltd. of New York, NY; Papaya Holdings Ltd. of Central, Hong Kong; Quanyun Electronics Co., Ltd...; (ii) Identify any public health, safety, or welfare concerns in the United States relating to the...

  14. Geothermal technology publications and related reports: A bibliography, January 1986 through December 1987

    Energy Technology Data Exchange (ETDEWEB)

    Tolendino, C.D. (ed.)

    1988-08-01

    Sandia publications resulting from DOE programs in Geothermal Technologies, Magma Energy and Continental Scientific Drilling are listed for reference. The RandD includes borehole-related technologies, in situ processes, and wellbore diagnostics.

  15. Public Relations Efforts for the Third World: Images in the News.

    Science.gov (United States)

    Albritton, Robert B.; Manheim, Jarol B.

    1985-01-01

    Found that, after Argentina, Indonesia, Korea, the Philippines, and Turkey hired U. S. public relations consultants, their news image in the "New York Times" improved in positive coverage and portrayal as more cooperative nations. (PD)

  16. Archive of Census Related Products (ACRP): 1990 Public Use Microdata Sample Areas (PUMA) Boundary Files

    Data.gov (United States)

    National Aeronautics and Space Administration — The 1990 Public Use Microdata Sample Areas (PUMA) Boundary Files portion of the Archive of Census Related Products (ACRP) consists of 5% sample (apuma) and 1% sample...

  17. Key issues of public relations of Europe: Findings from the European Communication Monitor 2007-2014

    Directory of Open Access Journals (Sweden)

    Dejan Vercic

    2014-10-01

    Full Text Available European Communication Monitor is the largest longitudinal research project in public relations practice in the world. Data collected annually from 2007 to 2014 show that practitioners perceive five issues as the most important for their work: linking business strategy and communication, coping with the digital evolution and social web, building and maintaining trust, dealing with the demand for more transparency and active audiences, and dealing with the speed and volume of information flow. Perception of the importance of various issues for the practice of public relations is largely dependent on the gender, geography (division between Northern and Western vs. Southern and Eastern Europe, and sector in which a practitioner works (corporate, government, NGO or agency. While gender and sectorial differences studied in academic public relations literature, divisions in public relations practice between North-Western and South-Eastern Europe are largely ignored.

  18. Harnessing the Power of Media Relations and Social Media and Public Outreach

    OpenAIRE

    Farmer, Andrea; Pinkerton, Jim; Pipkin, Erin; Riggs, Nathan

    2013-01-01

    This presentation discusses strategies for launching a simple, yet effective, campaign through media relations and social media for public outreach. Key points regarding protocol and time management will be covered.

  19. Defining the public, defining sociology: hybrid science-public relations and boundary-work in early American sociology.

    Science.gov (United States)

    Evans, Michael S

    2009-01-01

    In this paper, I examine how scientific disciplines define their boundaries by defining the publics with whom they engage. The case study is an episode in the development of early American sociology. In response to the dual challenge of credibility set up by the conflict between religious Baconian science and secular positivist science, key actors engaged in specific strategies of boundary-work to create their desired "sociological public"--a hybrid form of science-public relations that appealed to hostile university scientists while excluding a supportive religious audience from participation in the production of scientific knowledge. Using this case, I offer two specific insights. First I illustrate how, in the pursuit of scientific credibility, actors engage in boundary-work to differentiate audiences, not just practitioners. Such defining of publics is constitutive of scientific disciplines in their formative stage. Second, I demonstrate how audience boundaries can be redefined through the capture of existing boundary objects. Specifically, the removal of informational content in key boundary objects creates durable boundaries that are difficult to overcome.

  20. How European public relations men and women perceive the impact of their professional activities

    OpenAIRE

    Verhoeven, P.; Aarts, N.

    2010-01-01

    Starting from the theoretical perspective of gendered discourses, a secondary analysis of the data from the European Communication Monitors of 2008 and 2009, an annual survey about trends in the profession of public relations, was conducted on gender differences. The pilot study shows that female public relations professionals in most of Europe perceive their organisational influence to have less impact than those of men on the strategic decision making and planning of their organisations. Se...

  1. A typology of health marketing research methods--combining public relations methods with organizational concern.

    Science.gov (United States)

    Rotarius, Timothy; Wan, Thomas T H; Liberman, Aaron

    2007-01-01

    Research plays a critical role throughout virtually every conduit of the health services industry. The key terms of research, public relations, and organizational interests are discussed. Combining public relations as a strategic methodology with the organizational concern as a factor, a typology of four different research methods emerges. These four health marketing research methods are: investigative, strategic, informative, and verification. The implications of these distinct and contrasting research methods are examined.

  2. Uplatnění žen v oboru public relations

    OpenAIRE

    Bražinová, Michaela

    2007-01-01

    In many books on marketing communications, public relations are said to be a field dominated by women without giving any evidence or reasons for such a conclusion. This thesis called The Exercise of Women in Public Relations is based on an assumption , that there are some specific and describable manifestations and features concerning communication and estabilishing into and manintaining relationships that predetermine women for succesfull practice within the field, but that the real position...

  3. A CONSOLIDATED MODEL OF ANALYSIS OF THE RELATIONS BETWEEN POLITICS AND MANAGEMENT WITHIN PUBLIC ORGANIZATIONS

    OpenAIRE

    Catalina Maria GEORGESCU; Tudor NISTORESCU

    2011-01-01

    An interdisciplinary approach which combines the theoretical, empirical and conceptual dimensions, the present study tries to offer a new work perspective on the assessment and modeling of the relation between the management of public organizations and the political environment. The theoretical research was centered on reviewing the literature on the relation between the management of public organizations and the political environment. The empirical research was materialized by modeling with ...

  4. A RESEARCH ON EFFECTIVENESS OF SOCIAL MEDIA PRACTICES OF HOSPITALS’ PUBLIC RELATIONS DEPARTMENTS IN TURKEY

    OpenAIRE

    SÜTÇÜ, CEM S.; ERDAL, CENGİZ

    2014-01-01

    The aim of this study is to reveal performance level of public relations departments at the hospitals in terms of customer satisfaction and effectiveness of social media practices in Turkey. Besides, this study is also supposed to exert how effective technological developments and new communication applications have been adapted to public relations practices by the health sector and how this adaptation perceived by target audiences. Therefore a research, which consists of two steps, has been ...

  5. Public relations activities of the Service Hall for Kashiwazaki-Kariwa Nuclear Power Station

    International Nuclear Information System (INIS)

    Kono, T.

    1998-01-01

    This article includes information of the Service Hall for Kashiwazaki-Kariwa Nuclear Power Station. About 30% of the total electricity production in Japan is due to 16 power stations and 52 reactors. The service hall is a kind of atomic power pavilion for public relations. In Japan, each nuclear power station has such a pavilion, which acts a a center of public relations activities for the atomic power. (S. Grainger)

  6. Contribution of Public Relations to Organizational Decision Making : Insights from the Literature

    OpenAIRE

    Mykkänen, Markus; Vos, Marita

    2015-01-01

    The purpose of this paper is to clarify the contribution of public relations practitioners to organizational decision making and, in particular, how this has been seen in peer-reviewed journals over the last 10 years. After a literature search, 38 articles originating from 26 different journals were further analyzed using thematic analysis. The period investigated ranged from the start of 2002 to October 2012. In the general literature on the roles of public relations practitio...

  7. SOCIAL MEDIA USAGE AS A PUBLIC RELATIONS APPLICATION:CHANGE.ORG ZEYTINHAYATTIR SIGNATURE CAMPAIGNRESEARCH

    OpenAIRE

    TEZCAN, Elif Tuba

    2017-01-01

    Social media is most basic common way of socializing in the field of public relations; Using social media to create a common thought on common interest or joke, they gave birth to online signature campaigns. Signature campaigns used in Public Relation have an important place in creating a social platform. That individuals can freely share their emotions and thoughts, build crowdsourcing, act towards a certain goal and support signature campaigns is a social phenomenon. Individuals can freely ...

  8. PUBLIC RELATIONS ON THE EDUCATIONAL MARKET OF REPUBLIC OF TATARSTAN: HISTORY AND PROSPECTS

    Directory of Open Access Journals (Sweden)

    Olga Vladimirovna Kozlova

    2014-10-01

    Full Text Available Modern domestic science designed periodization of the development of public relations in Russia as a kind of professional activity. The authors traced the path of development of public relations as an academic specialty at the federal and regional levels (the experience of the Republic of Tatarstan. The chronological scope of the study: 1990 - to the present day. Characteristic features of the educational market of Tatastan are: demographic "failure", the reduction of budget places on humanitarian academic programs, high competition among universities.The purpose of the study was to examine the possibilities of using the tools of integrated marketing communications in promotion of academic program «Advertising and Public Relations» (BA in the educational market of the Republic of Tatarstan.Data for this study were collected by the experience of the Department of History and Public Relations of the Kazan National Research Technical University named after A.N. Tupolev.The Methods of the undertaking the work: theoretical analysis, sociological survey, information audit, interviews.The results of the study show the necessity to use these tools to promote academic program «Advertising and Public Relations»: advertising, public relations, special events, exhibition activities, Internet communications, direct marketing, and informal communication.

  9. PERAN PUBLIC RELATIONS SEBAGAI PENDUKUNG MANAJEMEN DI RUMAH SAKIT UMUM DR. PIRNGADI KOTA MEDAN

    Directory of Open Access Journals (Sweden)

    Indah Kemala Hasibuan

    2017-08-01

    Full Text Available The research is titled "The Role of Public Relations as a Management Support Hospital General Dr. Pirngadi Medan City "and discusses the role of public relations in order to improve the image of the hospital which describes the public relations image of the hospital to maintain (maintenance of image and restore the image of the hospital (recovery of image when carrying out its role as a supporter of management. This study aims to answer the problems that have been formulated. The detailed objectives of this study was to determine achievable extent of successful public relations duties to support the management to minimize patient complaints about inpatient services Jamkesmas participants in improving the image of the hospital in General Hospital Dr. Pirngadi Medan. The study population was inpatients General Hospital Dr. Pirngadi Jamkesmas Medan which is a participant during the month of January 2009 and aged 17 to 50 years. While the number of samples used to determine the Taro Yamane and using proportional random sampling technique. To answer the problems that have been formulated, used descriptive method with quantitative approach. From the analysis found the success rate of maintaining public relations image of the hospital by providing the best services at 65.12%, and restore the image of the hospital by providing the right solution for 62.79% proving that the role of public relations as a management support works.

  10. A CONSOLIDATED MODEL OF ANALYSIS OF THE RELATIONS BETWEEN POLITICS AND MANAGEMENT WITHIN PUBLIC ORGANIZATIONS

    Directory of Open Access Journals (Sweden)

    Catalina Maria GEORGESCU

    2011-01-01

    Full Text Available An interdisciplinary approach which combines the theoretical, empirical andconceptual dimensions, the present study tries to offer a new workperspective on the assessment and modeling of the relation between themanagement of public organizations and the political environment. Thetheoretical research was centered on reviewing the literature on the relationbetween the management of public organizations and the politicalenvironment. The empirical research was materialized by modeling with theregression technique of several aspects integrated to the relations betweenthe management of human resources within public organizations in theeducation field and the external political environment.

  11. The relation between public speaking anxiety and social anxiety: a review.

    Science.gov (United States)

    Blöte, Anke W; Kint, Marcia J W; Miers, Anne C; Westenberg, P Michiel

    2009-04-01

    This article reviewed the literature on public speaking anxiety in the context of social phobia subtyping. In total, 18 empirical studies on subtype issues related to public speaking anxiety were analyzed. Results of the reviewed studies are discussed in relation to their research method, that is, whether it focused on qualitative or quantitative aspects of subtype differences and whether it used a clinical or community sample. Evidence supported the premise that public speaking anxiety is a distinct subtype, qualitatively and quantitatively different from other subtypes of social phobia. The significance of this finding for social phobia studies using speech tasks to assess participants' state anxiety and behavioral performance is discussed.

  12. Perspektif Public Relations (KajianTentang Marketing PT. Radio Suara Mandala 96,4 FM Banyuwangi

    Directory of Open Access Journals (Sweden)

    Abdi Fauji Hadiono

    2017-10-01

    Full Text Available Public relations adalah keseluruhan upaya yang dilakukan secara terencana dan berkesinambungan dalam rangka menciptakan dan memelihara niat baik (good will dan saling pengertian antara suatu organisasi dengan segenap khalayaknya. Masalah yang diteliti dalam penelitian ini adalah Marketing yang menggunakan public relationspada PT. Radio Suara Mandala 96,4 Fm Banyuwangi. Peneliti menggunakan metode penelitian kualitatif. Dalam melakukan pengumpulan data peneliti memakai metode wawancara, observasi partisipan dan dokumentasi, kemudian data yang dikumpul di olah dan dianalisa dengan menggunakan interactive model Miles dan Huberman, yang terdiri dari tiga rangkaian komponen, yaitu: Reduksi data (data reduction, penyajian data(data display, dan penarikan serta pengujian kesimpulan (drawing and verifying conclusion. Hal yang peneliti lakukan untuk menguji keabsahan data adalah, Trianggulasi Metode dilakukan dengan cara membandingkan informasi atau data  marketing di PT. Radio Suara Mandala 96,4 Fm Banyuwangi menggunakan public relations. Trianggulasi Sumber menggali kebenaran informasi data  marketing di PT. Radio Suara Mandala 96,4 Fm Banyuwangi menggunakan public relations melalui berbagai metode dan sumber perolehan data. Trianggulasi Teori Hasil akhir penelitian kualitatif berupa sebuah rumusan informasi dari data  marketing di PT. Radio Suara Mandala 96,4 FmBanyuwangi menggunakan public relations. Objek dari penelitian ini meliputi Internal PT.  Radio Suara Mandala 96.4 FM, kemudian dari pihak klien yaitu Hotel Santika dan Sisikmelik Batik Banyuwangi. Dari hasil penelitian ini di ketahui bahwa di  PT.  Radio Suara Mandala 96.4 FM, marketing yang menggunakan public relations dengan 3 kriteria, diantaranya Pembuatan Strategi marketing (penelitian, membentuk tujuan pemasaran, Penerapan Strategi marketing (mengimplementasikan rencana public relations dan Evaluasi strategi marketing (mengevaluasikan hasil menggunakan public relation

  13. EFFECT OF TURKISH PUBLIC DIPLOMACY ACTIVITIES ON RELATIONS BETWEEN TURKEY AND GEORGIA

    Directory of Open Access Journals (Sweden)

    Sinem Celik

    2016-11-01

    Full Text Available The aim of this article is to analyze the impact power of Turkish public diplomacy performed towards Georgia to empower the relation between both countries. Within the scope of this article, after public diplomacy term was discussed in many aspects, some of the important activities of the actors of Turkish public diplomacy have also been mentioned. When these activities are examined, it has been observed that non-governmental organizations failed to show the desired level of asset compared to government agencies in Georgia. Besides, when Turkish public diplomacy activities are examined as a whole, it has been remarked that these activities play an effective role to gain the sympathy of the Georgian. However, it has been concluded that the impacts of these activities on Turkey- Georgia relations are limited especially due to the Russian influence on relations with each of these two countries.

  14. Effects of Public Relations Activities on Customer Satisfaction in the University Libraries

    Directory of Open Access Journals (Sweden)

    Ayşe Gedikçi, Öndoğan

    2013-11-01

    Full Text Available Like all organizations in the process of globalization, university libraries also have focused on their customers much more in order to continue their existence and they have diversified their services in order to increase customer satisfaction. Customer satisfaction emerges as a result of integration of many interdependent components. In this study, public relations works, the most important factor affecting the customer satisfaction, are handled and it is tried to determine the effect of public relations works conducted at Selcuk University Central Library on the customer satisfaction. In the study used descriptive methods, data were obtained from all customer groups who came to the Central Library through questionnaire. It was come out that all customer groups who came to the Central Library were satisfied with public relations works related to the library's physical elements and service elements, but they were not content with public relations works conducted out of the organization in order to improve the customer relations. In consequence of the research, it was observed that the variable that customers gives more importance is the physical elements variable ( =3,86. The most intense relationship between variables is between service element with the physical elements (r=0,667, p<0,01 and public relations elements (r=0,642, p<0,0.

  15. Signaling and molecular basis of bone marrow niche angiogenesis in leukemia

    NARCIS (Netherlands)

    Shirzad, R.; Shahrabi, S.; Ahmadzadeh, A.; Kampen, K. R.; Shahjahani, M.; Saki, N.

    2016-01-01

    Angiogenesis, the process of blood vessel formation, is necessary for tissue survival in normal and pathologic conditions. Increased angiogenesis in BM niche is correlated with leukemia progression and resistance to treatment. Angiogenesis can interfere with disease progression and several

  16. Labelled drug-related public expenditure in relation to gross domestic product (GDP) in Europe: a luxury good?

    Science.gov (United States)

    Prieto, Luis

    2010-05-17

    "Labelled drug-related public expenditure" is the direct expenditure explicitly labelled as related to illicit drugs by the general government of the state. As part of the reporting exercise corresponding to 2005, the European Monitoring Centre for Drugs and Drug Addiction's network of national focal points set up in the 27 European Union (EU) Member States, Norway, and the candidates countries to the EU, were requested to identify labelled drug-related public expenditure, at the country level. This was reported by 10 countries categorised according to the functions of government, amounting to a total of EUR 2.17 billion. Overall, the highest proportion of this total came within the government functions of Health (66%), and Public Order and Safety (POS) (20%). By country, the average share of GDP was 0.023% for Health, and 0.013% for POS. However, these shares varied considerably across countries, ranging from 0.00033% in Slovakia, up to 0.053% of GDP in Ireland in the case of Health, and from 0.003% in Portugal, to 0.02% in the UK, in the case of POS; almost a 161-fold difference between the highest and the lowest countries for Health, and a 6-fold difference for POS. Why do Ireland and the UK spend so much in Health and POS, or Slovakia and Portugal so little, in GDP terms? To respond to this question and to make a comprehensive assessment of drug-related public expenditure across countries, this study compared Health and POS spending and GDP in the 10 reporting countries. Results found suggest GDP to be a major determinant of the Health and POS drug-related public expenditures of a country. Labelled drug-related public expenditure showed a positive association with the GDP across the countries considered: r = 0.81 in the case of Health, and r = 0.91 for POS. The percentage change in Health and POS expenditures due to a one percent increase in GDP (the income elasticity of demand) was estimated to be 1.78% and 1.23% respectively. Being highly income elastic

  17. Labelled drug-related public expenditure in relation to gross domestic product (GDP) in Europe: a luxury good?

    LENUS (Irish Health Repository)

    Prieto, Luis

    2010-01-01

    "Labelled drug-related public expenditure" is the direct expenditure explicitly labelled as related to illicit drugs by the general government of the state. As part of the reporting exercise corresponding to 2005, the European Monitoring Centre for Drugs and Drug Addiction\\'s network of national focal points set up in the 27 European Union (EU) Member States, Norway, and the candidates countries to the EU, were requested to identify labelled drug-related public expenditure, at the country level. This was reported by 10 countries categorised according to the functions of government, amounting to a total of EUR 2.17 billion. Overall, the highest proportion of this total came within the government functions of Health (66%), and Public Order and Safety (POS) (20%). By country, the average share of GDP was 0.023% for Health, and 0.013% for POS. However, these shares varied considerably across countries, ranging from 0.00033% in Slovakia, up to 0.053% of GDP in Ireland in the case of Health, and from 0.003% in Portugal, to 0.02% in the UK, in the case of POS; almost a 161-fold difference between the highest and the lowest countries for Health, and a 6-fold difference for POS. Why do Ireland and the UK spend so much in Health and POS, or Slovakia and Portugal so little, in GDP terms? To respond to this question and to make a comprehensive assessment of drug-related public expenditure across countries, this study compared Health and POS spending and GDP in the 10 reporting countries. Results found suggest GDP to be a major determinant of the Health and POS drug-related public expenditures of a country. Labelled drug-related public expenditure showed a positive association with the GDP across the countries considered: r = 0.81 in the case of Health, and r = 0.91 for POS. The percentage change in Health and POS expenditures due to a one percent increase in GDP (the income elasticity of demand) was estimated to be 1.78% and 1.23% respectively. Being highly income elastic

  18. The role of public relations for image creating in health services: a sample patient satisfaction survey.

    Science.gov (United States)

    Kirdar, YalçIn

    2007-01-01

    This study discusses the role of public relations for image creating in health services. Hospitals require public relations activities to distinguish them from competitors, provide bidirectional communication between the society and the hospital, and assist to create of a strong hospital image and culture. A satisfaction survey was conducted on 264 patients who have received health services at Maltepe University Hospital. The research focused on how the Hospital's examination, care, catering and physical services; doctor and nurse politeness towards patients and patient relatives, their attitudes and behaviors; examination, check-in, bedding and discharge operations; public relations activities in and out of the hospital were perceived. Another subject of the study was the degree of recommendation of patients who have been served by the hospital's health services to prospective patients seeking treatment.

  19. Intellectual Capital Disclosure at Czech Public Universities in Relation to the Stakeholder Information Need

    Directory of Open Access Journals (Sweden)

    Kateřina Kuralová

    2016-01-01

    Full Text Available The purpose of this paper is to examine the extent and quality of intellectual capital disclosure at Czech public universities in relation to information need of identified stakeholders – students. This research is based on the theoretical framework for voluntary intellectual capital disclosure, the proposed intellectual capital disclosure index, the identification of stakeholders including their information need as well as the content analysis of the universities’ annual reports has been applied. The quality of disclosed information on intangible resources in public universities in the Czech Republic is in the middle level. In the highest quality is disclosed relational capital, followed by structural and human capital. Information need of students is highest for information falling under the relational capital followed by structural capital and human capital. This study opens new approach regarding intellectual capital disclosure including suggested recommendations for Czech public universities, as there was no research related to the issue conducted in the past.

  20. The influence of nuclear risk sense to atomic industry's public relation

    International Nuclear Information System (INIS)

    Biryukova, P.; Kazakevich, Yu.

    2001-01-01

    The goal of this report is estimation of the influence of sensing of nuclear risk to atomic industry's public relation. In this report the reasons of the negative relation to nuclear energetic owing to inadequate sensing of the risk dealing with this fields have been represented. (authors)

  1. Review of Selected Dissertations Addressing School Public Relations, Administrator Communication, and Conflict Resolution

    Science.gov (United States)

    Decman, John M.; Simieou, Felix, III

    2009-01-01

    This article is an extension to Kowalski's (2005) identification of possible lines of scholarly inquiry into themes related to schools and public relations. The article first cites professional accreditation standards for educational leaders as significant factors in providing a framework for increased scholarly inquiry. It then summarizes the…

  2. 2015 Copyright © 2015, CRISA Publications alCOHOl usE RElaTED

    African Journals Online (AJOL)

    Alcohol-related violence resulting in injury is a global public health problem and. Africa is no exception. In the country of Ethiopia, there is a lack of statistical evidence regarding this issue. The aim of this study was to investigate the incidence prevalence of alcohol-related violence and injury and its associative factors.

  3. 75 FR 64710 - Joint Public Roundtable on Issues Related to the Clearing of Credit Default Swaps

    Science.gov (United States)

    2010-10-20

    ... COMMODITY FUTURES TRADING COMMISSION SECURITIES AND EXCHANGE COMMISSION [Release No. 34-63112, File No. 4-615] Joint Public Roundtable on Issues Related to the Clearing of Credit Default Swaps... certain issues related to the clearing of Credit Default Swaps in the context of the Agencies rulemaking...

  4. [Public relations in institutions and establishments of the health administration system].

    Science.gov (United States)

    Martynenko, A V

    2002-01-01

    The article is dedicated to development of directions and specific functions of the health system bodies/institutions public relations (PR) activities. Priorities are set forth depending on the form of property thereof. A complex use of approaches toward carrying out of PR activities permits optimizing work both within the system itself and relations with the society as a whole.

  5. A novel compound, NP-184, inhibits the vascular endothelial growth factor induced angiogenesis.

    Science.gov (United States)

    Lin, Kuan-Ting; Lien, Jin-Cherng; Chung, Ching-Hu; Kuo, Sheng-Chu; Huang, Tur-Fu

    2010-03-25

    Angiogenesis is observed in many diseases, such as tumor progression, diabetes and rheumatoid arthritis; it is a process that involves proliferation, migration, differentiation and tube formation of endothelial cells. Vascular endothelial growth factor (VEGF) plays an important role in angiogenesis by induction of these endothelial functions. Thus, inhibition of these critical angiogenic steps is a practical therapeutic strategy for those diseases. NP-184 is a substituted benzimidazole analogue which exhibits a potent anti-thrombotic activity. In this report, NP-184 inhibited the viability of human umbilical vascular endothelial cells (HUVEC) in a concentration-dependent manner, and caused cell apoptosis as examined by cell-cycle analysis and Annexin V staining with flow cytometry. NP-184 also concentration-dependently inhibited the HUVEC migration, tube formation on Matrigel, and rat aortic ring sprouting stimulated by VEGF. Regarding the intracellular signal transduction, NP-184 concentration-dependently interfered with the activation of AKT, ERK and the nuclear translocation of NF-kappaB. In vivo study showed that NP-184 dose-dependently reduced angiogenesis in Matrigel plug assay. These results indicate that NP-184 is a potential candidate for developing the treatment of angiogenesis related-diseases.

  6. Bee products prevent VEGF-induced angiogenesis in human umbilical vein endothelial cells

    Directory of Open Access Journals (Sweden)

    Mishima Satoshi

    2009-11-01

    Full Text Available Abstract Background Vascular endothelial growth factor (VEGF is a key regulator of pathogenic angiogenesis in diseases such as cancer and diabetic retinopathy. Bee products [royal jelly (RJ, bee pollen, and Chinese red propolis] from the honeybee, Apis mellifera, have been used as traditional health foods for centuries. The aim of this study was to investigate the anti-angiogenic effects of bee products using human umbilical vein endothelial cells (HUVECs. Methods In an in vitro tube formation assay, HUVECs and fibroblast cells were incubated for 14 days with VEGF and various concentrations of bee products [RJ, ethanol extract of bee pollen, ethanol extract of Chinese red propolis and its constituent, caffeic acid phenethyl ester (CAPE]. To clarify the mechanism of in vitro angiogenesis, HUVEC proliferation and migration were induced by VEGF with or without various concentrations of RJ, bee pollen, Chinese red propolis, and CAPE. Results RJ, bee pollen, Chinese red propolis, and CAPE significantly suppressed VEGF-induced in vitro tube formation in the descending order: CAPE > Chinese red propolis >> bee pollen > RJ. RJ and Chinese red propolis suppressed both VEGF-induced HUVEC proliferation and migration. In contrast, bee pollen and CAPE suppressed only the proliferation. Conclusion Among the bee products, Chinese red propolis and CAPE in particular showed strong suppressive effects against VEGF-induced angiogenesis. These findings indicate that Chinese red propolis and CAPE may have potential as preventive and therapeutic agents against angiogenesis-related human diseases.

  7. Mechanotransduction-modulated fibrotic microniches reveal the contribution of angiogenesis in liver fibrosis

    Science.gov (United States)

    Liu, Longwei; You, Zhifeng; Yu, Hongsheng; Zhou, Lyu; Zhao, Hui; Yan, Xiaojun; Li, Dulei; Wang, Bingjie; Zhu, Lu; Xu, Yuzhou; Xia, Tie; Shi, Yan; Huang, Chenyu; Hou, Wei; Du, Yanan

    2017-12-01

    The role of pathological angiogenesis on liver fibrogenesis is still unknown. Here, we developed fibrotic microniches (FμNs) that recapitulate the interaction of liver sinusoid endothelial cells (LSECs) and hepatic stellate cells (HSCs). We investigated how the mechanical properties of their substrates affect the formation of capillary-like structures and how they relate to the progression of angiogenesis during liver fibrosis. Differences in cell response in the FμNs were synonymous of the early and late stages of liver fibrosis. The stiffness of the early-stage FμNs was significantly elevated due to condensation of collagen fibrils induced by angiogenesis, and led to activation of HSCs by LSECs. We utilized these FμNs to understand the response to anti-angiogenic drugs, and it was evident that these drugs were effective only for early-stage liver fibrosis in vitro and in an in vivo mouse model of liver fibrosis. Late-stage liver fibrosis was not reversed following treatment with anti-angiogenic drugs but rather with inhibitors of collagen condensation. Our work reveals stage-specific angiogenesis-induced liver fibrogenesis via a previously unrevealed mechanotransduction mechanism which may offer precise intervention strategies targeting stage-specific disease progression.

  8. Availability of Health-Related Programs in Private and Public Prisons.

    Science.gov (United States)

    Baćak, Valerio; Ridgeway, Greg

    2018-01-01

    Little is known about the resources available to protect inmates' health in private prisons compared to their public counterparts. This is the first national-level study that exclusively examined the availability of health-related programs in private and public prisons in the United States. We applied propensity score weighting and doubly robust estimation to compare private prisons to comparable public prisons. Data were self-reported by prison administrators as part of the 2005 Census of State and Federal Adult Correctional Facilities. We found that private prisons offered fewer substance dependency, psychological/psychiatric, and HIV/AIDS-related programs. But the differences were progressively reduced when the comparison was limited to public prisons most similar on a variety of facility-level characteristics. The extent to which the two types of prisons differ is closely tied to the characteristics of the facilities that are compared.

  9. Gene therapy and angiogenesis in patients with coronary artery disease

    DEFF Research Database (Denmark)

    Kastrup, Jens

    2010-01-01

    -blind placebo-controlled trials could not confirm the initial high efficacy of either the growth factor protein or the gene therapy approaches observed in earlier small trials. The clinical studies so far have all been without any gene-related serious adverse events. Future trials will focus on whether...... an improvement in clinical results can be obtained with a cocktail of growth factors or by a combination of gene and stem cell therapy in patients with severe coronary artery disease, which cannot be treated effectively with current treatment strategies....... of VEGF and FGF in patients with coronary artery disease. The initial small and unblinded studies with either recombinant growth factor proteins or genes encoding growth factors were encouraging, demonstrating both clinical improvement and evidence of angiogenesis. However, subsequent larger double...

  10. Expenditure Rules Related to Government Budget (under the Public Finance Act 2009

    Directory of Open Access Journals (Sweden)

    Małgorzata Cilak

    2013-10-01

    Full Text Available The article is devoted to expenditure rules related to government budget, specified in Public Finance Act. The object of analysis is the legal con-struction and functioning of expenditure rules. The article tries to respond on a question of effectiveness of these restrictions of conduct of budgetary policy. The analysis covers the rules in articles 112a–112d and 86 of Public Finance Act.

  11. Private Administration – Favorable Environment for Implementing Programs and Campaigns of Public Relations?

    Directory of Open Access Journals (Sweden)

    Simona HAIDAU

    2012-11-01

    Full Text Available This paper refer to decision of the private administration organizations from the region northeast of Romania to implement programs and public relations campaigns from the socio-economic context in the current period. This decision of organizations above mentioned is strongly influenced by nature non-profit purposes they have, more precisely, to be involved in carrying out the public interest or community.

  12. A quantitative evaluation of the relative status of journal and conference publications in computer science.

    OpenAIRE

    Coyle, Lorcan; Freyne, Jill; Smyth, Barry; Cunningham, Padraig

    2010-01-01

    While it is universally held by computer scientists that conference publications have a higher status in computer science than in other disciplines there is little quantitative evidence in support of this position. The importance of journal publications in academic promotion makes this a big issue since an exclusive focus on journal papers will miss many significant papers published at conferences in computer science. In this paper we set out to quantify the relative importance of journ...

  13. Scientists and public involvement: a consultation on the relation between malaria, vector control and transgenic mosquitoes.

    Science.gov (United States)

    Boëte, Christophe

    2011-12-01

    Among the hopes for vector-based malaria control, the use of transgenic mosquitoes able to kill malaria parasites is seen as a potential way to interrupt malaria transmission. While this potential solution is gaining some support, the ethical and social aspects related to this high-tech method remain largely unexplored and underestimated. Related to those latter points, the aim of the present survey is to determine how scientists working on malaria and its vector mosquitoes perceive public opinion and how they evaluate public consultations on their research. This study has been performed through a questionnaire addressing questions related to the type of research, the location, the nationality and the perception of the public involvement by scientists. The results suggest that even if malaria researchers agree to interact with a non-scientific audience, they (especially the ones from the global North) remain quite reluctant to have their research project submitted in a jargon-free version to the evaluation and the prior-agreement by a group of non-specialists. The study, by interrogating the links between the scientific community and the public from the perspective of the scientists, reveals the importance of fostering structures and processes that could lead to a better involvement of a non specialist public in the actual debates linking scientific, technological and public health issues in Africa. Copyright © 2011 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.

  14. Ontology-based automatic identification of public health-related Turkish tweets.

    Science.gov (United States)

    Küçük, Emine Ela; Yapar, Kürşad; Küçük, Dilek; Küçük, Doğan

    2017-04-01

    Social media analysis, such as the analysis of tweets, is a promising research topic for tracking public health concerns including epidemics. In this paper, we present an ontology-based approach to automatically identify public health-related Turkish tweets. The system is based on a public health ontology that we have constructed through a semi-automated procedure. The ontology concepts are expanded through a linguistically motivated relaxation scheme as the last stage of ontology development, before being integrated into our system to increase its coverage. The ultimate lexical resource which includes the terms corresponding to the ontology concepts is used to filter the Twitter stream so that a plausible tweet subset, including mostly public-health related tweets, can be obtained. Experiments are carried out on two million genuine tweets and promising precision rates are obtained. Also implemented within the course of the current study is a Web-based interface, to track the results of this identification system, to be used by the related public health staff. Hence, the current social media analysis study has both technical and practical contributions to the significant domain of public health. Copyright © 2017 Elsevier Ltd. All rights reserved.

  15. Notch-1 mediates hypoxia-induced angiogenesis in rheumatoid arthritis.

    Science.gov (United States)

    Gao, Wei; Sweeney, Catherine; Connolly, Mary; Kennedy, Aisling; Ng, Chin Teck; McCormick, Jennifer; Veale, Douglas J; Fearon, Ursula

    2012-07-01

    To examine the effect of hypoxia on Notch-1 signaling pathway components and angiogenesis in inflammatory arthritis. The expression and regulation of Notch-1, its ligand delta-like protein 4 (DLL-4) and downstream signaling components (hairy-related transcription factor 1 [HRT-1], HRT-2), and hypoxia-inducible factor 1α (HIF-1α) under normoxic and hypoxic conditions (1-3%) were assessed in synovial tissue specimens from patients with inflammatory arthritis and controls and in human dermal microvascular endothelial cells (HDMECs) by immunohistology, dual immunofluorescence staining (Notch-1/factor VIII), Western blotting, and real-time polymerase chain reaction. In vivo synovial tissue oxygen levels (tissue PO2) were measured under direct visualization at arthroscopy. HDMEC activation under hypoxic conditions in the presence of Notch-1 small interfering RNA (siRNA), the γ-secretase inhibitor DAPT, or dimethyloxalylglycine (DMOG) was assessed by Matrigel tube formation assay, migration assay, invasion assay, and matrix metalloproteinase 2 (MMP-2)/MMP-9 zymography. Expression of Notch-1, its ligand DLL-4, and HRT-1 was demonstrated in synovial tissue, with the strongest expression localized to perivascular/vascular regions. Localization of Notch-1 to synovial endothelium was confirmed by dual immunofluorescence staining. Notch-1 intracellular domain (NICD) expression was significantly higher in synovial tissue from patients with tissue PO2 of PO2 of >20 mm Hg (>3% O2). Exposure of HDMECs to 3% hypoxia induced HIF-1α and NICD protein expression and DLL-4, HRT-1, and HRT-2 messenger RNA expression. DMOG directly induced NICD expression, while Notch-1 siRNA inhibited hypoxia-induced HIF-1α expression, suggesting that Notch-1/HIF-1α signaling is bidirectional. Finally, 3% hypoxia-induced angiogenesis, endothelial cell migration, endothelial cell invasion, and proMMP-2 and proMMP-9 activities were inhibited by Notch-1 siRNA and/or the γ-secretase inhibitor DAPT. Our

  16. Competencies Needed in Oral Communication in English among Thai Undergraduate Public Relations Students: A Substantial Gap between Expectations and Reality

    Science.gov (United States)

    Pattanapichet, Fasawang; Chinokul, Sumalee

    2011-01-01

    This article investigates the competencies needed for oral communication in English among Thai undergraduate public relations students for handling public relations job interviews and performing entry-level public relations work. To identify these competencies, the study identified and involved all of the stakeholders in the data reliability…

  17. "I Like to Plan Events": A Document Analysis of Essays Written by Applicants to a Public Relations Program

    Science.gov (United States)

    Taylor, Ronald E.

    2016-01-01

    A document analysis of 249 essays written during a 5-year period by applicants to a public relations program at a major state university in the southeast suggests that there are enduring reasons why students choose to major in public relations. Public relations is described as a major that allows for and encourages creative expression and that…

  18. Angiogenesis is required for successful bone induction during distraction osteogenesis.

    Science.gov (United States)

    Fang, Tony D; Salim, Ali; Xia, Wei; Nacamuli, Randall P; Guccione, Samira; Song, HanJoon M; Carano, Richard A; Filvaroff, Ellen H; Bednarski, Mark D; Giaccia, Amato J; Longaker, Michael T

    2005-07-01

    The role of angiogenesis during mechanically induced bone formation is incompletely understood. The relationship between the mechanical environment, angiogenesis, and bone formation was determined in a rat distraction osteogenesis model. Disruption of either the mechanical environment or endothelial cell proliferation blocked angiogenesis and bone formation. This study further defines the role of the mechanical environment and angiogenesis during distraction osteogenesis. Whereas successful fracture repair requires a coordinated and complex transcriptional program that integrates mechanotransductive signaling, angiogenesis, and osteogenesis, the interdependence of these processes is not fully understood. In this study, we use a system of bony regeneration known as mandibular distraction osteogenesis (DO) in which a controlled mechanical stimulus promotes bone induction after an osteotomy and gradual separation of the osteotomy edges to examine the relationship between the mechanical environment, angiogenesis, and osteogenesis. Adult Sprague-Dawley rats were treated with gradual distraction, gradual distraction plus the angiogenic inhibitor TNP-470, or acute distraction (a model of failed bony regeneration). Animals were killed at the end of distraction (day 13) or at the end of consolidation (day 41) and examined with muCT, histology, and immunohistochemistry for angiogenesis and bone formation (n = 4 per time-point per group). An additional group of animals (n = 6 per time-point per group) was processed for microarray analysis at days 5, 9, 13, 21, and 41. Either TNP-470 administration or disruption of the mechanical environment prevented normal osteogenesis and resulted in a fibrous nonunion. Subsequent analysis of the regenerate showed an absence of angiogenesis by gross histology and immunohistochemical localization of platelet endothelial cell adhesion molecule in the groups that failed to heal. Microarray analysis revealed distinct patterns of expression of

  19. The Social Value of Public Relations in the Romanian Book Sector

    Directory of Open Access Journals (Sweden)

    Raluca Moise

    2016-03-01

    Full Text Available The aim of the present article is to identify the social and cultural value of Public Relations in the Romanian book sector. Our approach overpasses the functionalist perspective of Public Relations as an organizational discipline and considers Public Relations as a discipline that institutionalizes relationships and discourses that are commonly practiced in the society by mutual and tacit agreement. We investigate the current communication practices used by three Romanian publishing houses in order to generate and to increase the symbolic value of the book. In order to analyze the uses and practices of Public Relations of generating literary sociability at the level of Romanian society, we analysed the communication management through owned new media (websites, blogs, Facebook that three of the publishing houses in Romania have developed since their foundation. We analyzed the conversational competency in the online environment, using a complex methodology: starting from three Romanian publishing houses, selected on the basis of dimension, financial capacity and consumer perception of reputation, we have analyzed the content produced on the main owned-media channels used for public communication (websites, blogs, social media pages and accounts – Facebook, Twitter between June – October 2014. We also analyzed the quality of interaction, by taking into account the number of positive reactions to a post, the number of replies and the number of comments.

  20. Merging public relations with health communication in the context of university alcohol prevention.

    Science.gov (United States)

    Brummette, John

    2015-01-01

    The scope of this study is to determine whether social norms marketing should be further evaluated according to its ability to serve as a public relations tactic for universities. Based on a framework of social norms theory and strategic issues management, this study uses a web-based survey with university parents (N = 173) to identify relationships among exaggerated parental misperceptions of student binge drinking, parental awareness of alcohol prevention programs, and parental perceptions of organizational legitimacy. Findings from this study are used to make the argument that health communication and public relations should be viewed as interrelated concepts in the context of university alcohol prevention.

  1. FROM PUBLIC RELATIONS TO THE NEW CONCEPTS OF COMMUNICATION: TERMINOLOGICAL PROBLEMS

    Directory of Open Access Journals (Sweden)

    María Isabel Míguez González

    2013-11-01

    Full Text Available The terms public relations, communication management, corporate communication, institutional communication, business communication and organizational communication coexist in the professional field of communication without clear conceptual limits. In order to clarify this situation from an academic point of view, we reviewed the contributions about these terms made by Spanish authors, based on the oldest notion of public relations. The analysis shows significant discrepancies between different authors, who can not clearly define the scope of these concepts and their relationship to each other.

  2. SPREADING THE IDEAL OF MASS SHAREOWNERSHIP: PUBLIC RELATIONS AND THE NYSE

    Directory of Open Access Journals (Sweden)

    Janice Traflet (ed.

    2004-01-01

    Full Text Available In the 1950s, the New York Stock Exchange, led by President Keith Funston, embarked on an ambitious public relations campaign christened “Own Your Share of American Business.” This paper justaposes the “Own Your Share”campaign with earlier NYSE image-making efforts. Tracing the evolution in Exchange public relations sheds lights on how the Big Board gradually embraced mass shareownership as a worthy goal and endorsed mass merchandising as a legitimate way to achieve it.

  3. Strategies and techniques of communication and public relations applied to non-profit sector

    Directory of Open Access Journals (Sweden)

    Ioana – Julieta Josan

    2010-05-01

    Full Text Available The aim of this paper is to summarize the strategies and techniques of communication and public relations applied to non-profit sector.The approach of the paper is to identify the most appropriate strategies and techniques that non-profit sector can use to accomplish its objectives, to highlight specific differences between the strategies and techniques of the profit and non-profit sectors and to identify potential communication and public relations actions in order to increase visibility among target audience, create brand awareness and to change into positive brand sentiment the target perception about the non-profit sector.

  4. Inhibitory Effect of Endostar on Specific Angiogenesis Induced by Human Hepatocellular Carcinoma

    Directory of Open Access Journals (Sweden)

    Qing Ye

    2015-01-01

    Full Text Available To investigate the effect of endostar on specific angiogenesis induced by human hepatocellular carcinoma, this research systematically elucidated the inhibitory effect on HepG2-induced angiogenesis by endostar from 50 ng/mL to 50000 ng/mL. We employed fluorescence quantitative Boyden chamber analysis, wound-healing assay, flow cytometry examination using a coculture system, quantitative analysis of tube formation, and in vivo Matrigel plug assay induced by HCC conditioned media (HCM and HepG2 compared with normal hepatocyte conditioned media (NCM and L02. Then, we found that endostar as a tumor angiogenesis inhibitor could potently inhibit human umbilical vein endothelial cell (HUVEC migration in response to HCM after four- to six-hour action, inhibit HCM-induced HUVEC migration to the lesion part in a dose-dependent manner between 50 ng/mL and 5000 ng/mL at 24 hours, and reduce HUVEC proliferation in a dose-dependent fashion. Endostar inhibited HepG2-induced tube formation of HUVECs which peaked at 50 ng/mL. In vivo Matrigel plug formation was also significantly reduced by endostar in HepG2 inducing system rather than in L02 inducing system. It could be concluded that, at cell level, endostar inhibited the angiogenesis-related biological behaviors of HUVEC in response to HCC, including migration, adhesion proliferation, and tube formation. At animal level, endostar inhibited the angiogenesis in response to HCC in Matrigel matrix.

  5. Tpl2 Inhibitors Thwart Endothelial Cell Function in Angiogenesis and Peritoneal Dissemination

    Directory of Open Access Journals (Sweden)

    Wen-Jane Lee

    2013-09-01

    Full Text Available Angiogenesis is critical in the development of cancer, which involves several angiogenic factors in its peritoneal dissemination. The role of protein tumor progression locus 2 (Tpl2 in angiogenic factor-related endothelial cell angiogenesis is still unclear. To understand the precise mechanism(s of Tpl2 inhibition in endothelial cells, this study investigated the role of Tpl2 in mediating angiogenic signals using in vitro, in vivo, and ex vivo models. Results showed that inhibition of Tpl2 inhibitor significantly reduced peritoneal dissemination in a mouse model by positron emission tomography/computed tomography imaging. Simultaneously, inhibiting Tpl2 blocked angiogenesis in tumor nodules and prevented angiogenic factor-induced proliferating cell nuclear antigen (PCNA in endothelial cells. Vascular endothelial growth factor (VEGF or chemokine (C-X-C motif ligand 1 (CXCL1 increased Tpl2 kinase activity and phosphorylation in a dose- and time-dependent manner. Furthermore, Tpl2 inhibition or ablation by siRNA prevented the angiogenic signal-induced tube formation in Matrigel plug assay or aortic ring assay. Inhibiting Tpl2 also prevented the angiogenic factor-induced chemotactic motility and migration of endothelial cells. Tpl2 inhibition by CXCL1 or epidermal growth factor in endothelial cells was associated with inactivation of CCAAT/enhancer binding protein β, nuclear factor κ light-chain enhancer of activated B cells, and activating protein 1 and suppression of VEGF expression. Thus, Tpl2 inhibitors thwart Tpl2-regulated VEGF by inactivating transcription factors involved in angiogenic factor-triggered endothelial cell angiogenesis. These results suggest that the therapeutic inhibition of Tpl2 may extend beyond cancer and include the treatment of other diseases involving pathologic angiogenesis.

  6. Duplicate publications and related problems in published papers on oral and maxillofacial surgery.

    Science.gov (United States)

    Le, A; Moran, C M P; Bezuhly, M; Hong, P

    2015-07-01

    As duplicate publication is unethical, our aim was to find out how common it is among published papers on oral and maxillofacial surgery. We used PubMed to identify index articles published in 2010 in the Journal of Oral and Maxillofacial Surgery, the British Journal of Oral and Maxillofacial Surgery, and the European Journal of Cranio-Maxillo-Facial Surgery, and searched for possible duplicate publications from 2008 to 2012 using the first or second and last authors' names. Suspected duplicates were categorised into "non-duplicate" (no overlap), "duplicate" (identical results and conclusions), or "salami-sliced" publications (part of the index article repeated or continued). Of the 589 index articles, 17 (3%) had some form of duplication, but specifically, we found 3 duplicate, and 15 salami-sliced publications. Most redundant articles originated from China (n=4), followed by Italy, Japan, and Germany (3 from each) and the United States and Denmark (2 each). Of the 18 redundant publications, 9 did not reference the related index article. Duplicate material is still being published, and salami-slicing is relatively common among publications on oral and maxillofacial surgery. Further research is required into the extent and impact of this finding. Copyright © 2015 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

  7. Work-related social skills: Definitions and interventions in public vocational rehabilitation.

    Science.gov (United States)

    Phillips, Brian N; Kaseroff, Ashley A; Fleming, Allison R; Huck, Garrett E

    2014-11-01

    Social skills play an important role in employment. This study provides a qualitative analysis of salient work related social skills and interventions for addressing social skills in public vocational rehabilitation (VR). A modified consensual qualitative research (CQR) approach was taken to understand the elements and influence of work related social skills in public VR. Thirty-five counselors, supervisors, and administrators participated in semistructured interviews to provide their perspectives of work related social skills and the interventions they use for addressing these skills. Multiple aspects of work-related social skills were described as being important for VR consumer success. The most common work related social skills across all participants were nonverbal communication and the ability to connect with others. Primary social interventions included informal social skills training (SST), systems collaboration, and creating an appropriate job match. Public rehabilitation agency staff, constantly faced with addressing work related social skills, possess many insights about salient skills and interventions that can benefit future research and practice. Agencies currently address social skills deficits by providing interventions to both person and environment. The research provides directions for future research related to identification of social skills and interventions to address related deficits. (PsycINFO Database Record (c) 2014 APA, all rights reserved).

  8. Public opinion on age-related degradation in nuclear power plants

    International Nuclear Information System (INIS)

    Matsuda, Toshihiro

    2005-01-01

    The first objective of this study is to shed light on the public opinion on age-related degradation at nuclear power plants, namely, on how the general public recognizes or views age-related degradation, which is a safety-related issue and one of the factors contributing to accidents and failures which occur at nuclear power plants. The second objective is to look into the impacts of the accident at Mihama Unit 3, which was caused by a failure to check on the piping wall thickness, on the public opinion on age-related degradation. The first survey was conducted in August 2003, followed by the second survey in October 2004, two months after the accident. The surveys found that the age-related degradation is being perceived by people as one of the risk factors that affect the safety of nuclear power plants. The characteristics of the citizens' perceptions toward age-related degradation in the form of piping cracks are that: (a) many respondents feel uneasy but a relatively few people consider that nuclear operators are technologically capable of coping with this problem; (b) many people believe that radioactivity may be released; and (c) numerous respondents consider that signs of cracks must be thoroughly detected through inspections, while on the other hand, a large percentage of the respondents attribute the accident to improper inspections/maintenance. Based on these results, the government and nuclear operators are expected to give most illuminating explanation on the current situation of and remedial measures against age-related degradation at nuclear power plants. As for the effects of the Mihama-3 accident on the public opinion on age-related degradation, it was revealed that the accident has not so significantly affected the general view for the safety of nuclear power plants, but has newly or strongly aroused people's consciousness of two of the risk factors - improper inspections/maintenance and the age-related degradation of piping. (author)

  9. MACRO-PUBLIC RELATIONS: CRISIS COMMUNICATION IN THE AGE OF INTERNET

    Directory of Open Access Journals (Sweden)

    Zhongxuan Lin

    2013-12-01

    Full Text Available In order to study the crisis communication in the age of Internet, the study takes the battle between two Internet companies, Tencent and Qihoo, as a case study, but focuses more on their huge public audiences, which may be defined as a “macro-public” crowd. The study employs multiple research methods including survey, focus groups interviews and content analysis to explore their “macro-public relations” which may be driven by the spiral of silence and crowd psychology. This dynamic underground power is the reason that two companies employed similar public relations strategies in crisis communication but the results of the crisis were different. The study attempts to contribute to the knowledge base by defining and highlighting the power and function of “macro-public relations” for crisis communication in the age of Internet.

  10. Investigation of China’s national public relations strategy under globalization : the hotspots around the national media

    OpenAIRE

    雷, 紫雯

    2014-01-01

    This study investigates on China’s national public relations strategy under the globalization by analyzing the national media. In recent years, in order to improve the global public opinion environment, and to improve its national public relations capabilities that match its economic power status, China has actively strengthened its national public relations strategies, including making the national “media go out”, and building world-class media. By researching on the localization of Chinese ...

  11. Influence of Levamisole and Other Angiogenesis Inhibitors on Angiogenesis and Endothelial Cell Morphology in Vitro

    Energy Technology Data Exchange (ETDEWEB)

    Friis, Tina; Engel, Anne-Marie; Bendiksen, Christine D.; Larsen, Line S.; Houen, Gunnar, E-mail: gh@ssi.dk [Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut, Artillerivej 5, DK-2300 Copenhagen (Denmark)

    2013-06-24

    Angiogenesis, the formation of new blood vessels from existing vessels is required for many physiological processes and for growth of solid tumors. Initiated by hypoxia, angiogenesis involves binding of angiogenic factors to endothelial cell (EC) receptors and activation of cellular signaling, differentiation, migration, proliferation, interconnection and canalization of ECs, remodeling of the extracellular matrix and stabilization of newly formed vessels. Experimentally, these processes can be studied by several in vitro and in vivo assays focusing on different steps in the process. In vitro, ECs form networks of capillary-like tubes when propagated for three days in coculture with fibroblasts. The tube formation is dependent on vascular endothelial growth factor (VEGF) and omission of VEGF from the culture medium results in the formation of clusters of undifferentiated ECs. Addition of angiogenesis inhibitors to the coculture system disrupts endothelial network formation and influences EC morphology in two distinct ways. Treatment with antibodies to VEGF, soluble VEGF receptor, the VEGF receptor tyrosine kinase inhibitor SU5614, protein tyrosine phosphatase inhibitor (PTPI) IV or levamisole results in the formation of EC clusters of variable size. This cluster morphology is a result of inhibited EC differentiation and levamisole can be inferred to influence and block VEGF signaling. Treatment with platelet factor 4, thrombospondin, rapamycin, suramin, TNP-470, salubrinal, PTPI I, PTPI II, clodronate, NSC87877 or non-steriodal anti-inflammatory drugs (NSAIDs) results in the formation of short cords of ECs, which suggests that these inhibitors have an influence on later steps in the angiogenic process, such as EC proliferation and migration. A humanized antibody to VEGF is one of a few angiogenesis inhibitors used clinically for treatment of cancer. Levamisole is approved for clinical treatment of cancer and is interesting with respect to anti-angiogenic activity

  12. Tympanomastoid cholesterol granulomas: Immunohistochemical evaluation of angiogenesis.

    Science.gov (United States)

    Iannella, Giannicola; Di Gioia, Cira; Carletti, Raffaella; Magliulo, Giuseppe

    2017-08-01

    This study investigates the immunohistochemical expression of vascular endothelial growth factor (VEGF) and CD34 in patients treated for middle ear and mastoid cholesterol granulomas to evaluate the angiogenesis and vascularization of this type of lesion. A correlation between the immunohistochemical data and the radiological and intraoperative evidence of temporal bone marrow invasion and blood source connection was performed to validate this hypothesis. Retrospective study. Immunohistochemical expression of VEGF and CD34 in a group of 16 patients surgically treated for cholesterol granuloma was examined. Middle ear cholesteatomas with normal middle ear mucosa and external auditory canal skin were used as the control groups. The radiological and intraoperative features of cholesterol granulomas were also examined. In endothelial cells, there was an increased expression of angiogenetic growth factor receptors in all the cholesterol granulomas in this study. The quantitative analysis of VEGF showed a mean value of 37.5, whereas the CD34 quantitative analysis gave a mean value of 6.8. Seven patients presented radiological or intraoperative evidence of bone marrow invasion, hematopoietic potentialities, or blood source connections that might support the bleeding theory. In all of these cases there was computed tomography or intraoperative evidence of bone erosion of the middle ear and/or temporal bone structures. The mean values of VEGF and CD34 were 41.1 and 7.7, respectively. High values of VEGF and CD34 are present in patients with cholesterol granulomas. Upregulation of VEGF and CD34 is indicative of a remarkable angiogenesis and a widespread vascular concentration in cholesterol granulomas. 3b. Laryngoscope, 127:E283-E290, 2017. © 2017 The American Laryngological, Rhinological and Otological Society, Inc.

  13. Proinflammatory mediators stimulate neutrophil-directed angiogenesis.

    LENUS (Irish Health Repository)

    McCourt, M

    2012-02-03

    BACKGROUND: Vascular endothelial growth factor (VEGF; vascular permeability factor) is one of the most potent proangiogenic cytokines, and it plays a central role in mediating the process of angiogenesis or new blood vessel formation. Neutrophils (PMNs) recently have been shown to produce VEGF. HYPOTHESIS: The acute inflammatory response is a potent stimulus for PMN-directed angiogenesis. METHODS: Neutrophils were isolated from healthy volunteers and stimulated with lipopolysaccharide (LPS), tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), and anti-human Fas monoclonal antibody. Culture supernatants were assayed for VEGF using enzyme-linked immunosorbent assays. Culture supernatants from LPS- and TNF-alpha-stimulated PMNs were then added to human umbilical vein endothelial cells and human microvessel endothelial cells and assessed for endothelial cell proliferation using 5-bromodeoxyuridine labeling. Tubule formation was also assessed on MATRIGEL basement membrane matrix. Neutrophils were lysed to measure total VEGF release, and VEGF expression was detected using Western blot analysis. RESULTS: Lipopolysaccharide and TNF-alpha stimulation resulted in significantly increased release of PMN VEGF (532+\\/-49 and 484+\\/-80 pg\\/mL, respectively; for all, presented as mean +\\/- SEM) compared with control experiments (32+\\/-4 pg\\/mL). Interleukin 6 and Fas had no effect. Culture supernatants from LPS- and TNF-alpha-stimulated PMNs also resulted in significant increases (P<.005) in macrovascular and microvascular endothelial cell proliferation and tubule formation. Adding anti-human VEGF-neutralizing polyclonal antibody to stimulated PMN supernatant inhibited these effects. Total VEGF release following cell lysis and Western blot analysis suggests that the VEGF is released from an intracellular store. CONCLUSION: Activated human PMNs are directly angiogenic by releasing VEGF, and this has important implications for inflammation, capillary leak syndrome

  14. [CT and MRI imaging in tumoral angiogenesis].

    Science.gov (United States)

    de Bazelaire, C; Calmon, R; Chapellier, M; Pluvinage, A; Frija, J; de Kerviler, E

    2010-01-01

    Angiogenesis is the process of activating dormant endothelial cells to form new vessels, after stimulation and it is essential in tumor growth. In many types of cancer, angiogenesis results from the activation of oncogenes that stimulate the production of Vascular Endothelial Growth Factor (VEGF). However, these newly formed vessels have a great number of abnormalities: increased density of fragile and hyper-permeable microvessels, arterial-venous shunts, caliber abnormalities and flow instabilities susceptible to flow direction inversion according to interstitial pressure. Anti-angiogenic treatments inhibit VEGF activity, perceived as structural and functional normalization of the microvascular pattern, such as reduced density of microvessels and restored morphology of the remaining ones. Conventional imaging techniques are not sensible to these changes, at best they show tumor size stabilization, hence the need of new techniques. Microvascularization imaging can be achieved by detecting functional disturbances to blood flow and not by showing the microvasculature per se. These techniques are based in quantifying the enhancement in tumor due to the passage of contrast agent after injection or protons labeled by a magnetic field. Through these measurements, one can derive interstitial and blood volumes as well as the tissue perfusion and capillary wall permeability. Microvascular imaging has greatly benefited from the improvements seen in CT and MRI equipment allowing large volume coverage with high spatial and temporal resolutions as from the evolutions in the methods to calculate, present and compare maps of the microcirculation and it's heterogeneity. However, software to analyze microvascularization are still rare, limiting the technique's application and validation in large scale. Nevertheless, imaging of the microcirculation is useful throughout the care of the oncological patient: it can reinforce the suspicious nature of a lesion, suggest anti

  15. Public diplomacy and cooperation with non-governmental organizations in the liberal perspective of international relations

    Directory of Open Access Journals (Sweden)

    Natalia Broś

    2017-07-01

    Full Text Available This article discusses the issue of state cooperation with non-governmental organizations in public diplomacy. This has been explored in relation to the liberal perspective in international relations, which very clearly highlights the importance of NGOs as an influential participant in world politics. The article contains an analysis of the international system, categorizes the roles and functions of NGOs in international relations. It shows concepts on contemporary understanding of power and a clear focus on reinforcing and using components of soft power, including public diplomacy, in moden international relations. Methodological aspects are deepened by an analytical layer exploring Civil Society 2.0 Program, what is an example of an effective combination of diplomatic efforts between the state and NGOs to achieve common goals.

  16. Assessing the Impact of Globalization on U.S. Public Relations.

    Science.gov (United States)

    Fitzpatrick, Kathy R.; Whillock, Rita Kirk

    1993-01-01

    Surveys American public relations practitioners and finds that the majority of those surveyed said that their practices were not yet affected by globalization. Notes a strong perception that the impact will be realized in the future. Finds also a perceived need to develop a better understanding of the international marketplace and to upgrade…

  17. Students' Use of E-Mail in an Undergraduate Public Relations Course.

    Science.gov (United States)

    Kelleher, Tom; Dodd, Julie E.

    A study examined the use of e-mail between the students in an introductory public relations class and their instructor. E-mail use was parallel to the use of face-to-face communication, with students reporting that they used office time and e-mail primarily to ask questions about quizzes, tests, and assignments. Older students and students further…

  18. Think Bubbles and Socrates: Teaching Critical Thinking to Millennials in Public Relations Classes

    Science.gov (United States)

    Tallent, Rebecca J.; Barnes, Justin J.

    2015-01-01

    Critical thinking skills are crucial in the public relations profession, but teaching these skills to the Millennial Generation is vastly different from previous generations. How can a professor get past No Child Left Behind's dependence on test review guides and "everybody wins" in getting students to think for themselves? Using the…

  19. 77 FR 3794 - Certain Mobile Devices and Related Software; Request for Statements on the Public Interest

    Science.gov (United States)

    2012-01-25

    ... INTERNATIONAL TRADE COMMISSION [Investigation No. 337-TA-750] Certain Mobile Devices and Related Software; Request for Statements on the Public Interest AGENCY: U.S. International Trade Commission. ACTION: Notice. SUMMARY: Notice is hereby given that the presiding administrative law judge has issued a Final...

  20. The Impact of Proposition 13 on Public Employee Relations: The Case of Los Angeles.

    Science.gov (United States)

    Swimmer, Gene

    1982-01-01

    The impact of Proposition 13 and subsequent state bailout legislation on public employee relations in the City and County of Los Angeles (California) has been a new collective bargaining environment. The 1979 negotiations, where a countywide strike was narrowly averted, illustrate the hardening of management attitudes and union militancy. (MLF)