WorldWideScience

Sample records for angiogenesis related publications

  1. Publicity and public relations

    Science.gov (United States)

    Fosha, Charles E.

    1990-01-01

    This paper addresses approaches to using publicity and public relations to meet the goals of the NASA Space Grant College. Methods universities and colleges can use to publicize space activities are presented.

  2. Age-related macular degeneration: beyond anti-angiogenesis.

    Science.gov (United States)

    Kent, David L

    2014-01-06

    Recently, anti-vascular endothelial growth factor therapies for neovascular age-related macular degeneration have been developed. These agents, originally developed for their anti-angiogenic mechanism of action, probably also work through an anti-permeability effect in preventing or reducing the amount of leakage from submacular neovascular tissue. Other treatment modalities include laser photocoagulation, photodynamic therapy with verteporfin, and submacular surgery. In reality, these latter treatments can be similarly categorized as anti-angiogenic because their sole aim is destroying or removing choroidal neovascularization (CNV). At the cellular level, CNV resembles stereotypical tissue repair that consists of several matricellular components in addition to neovascularization. In the retina, the clinical term CNV is a misnomer since the term may more appropriately be referred to as aberrant submacular repair. Furthermore, CNV raises a therapeutic conundrum: To complete or correct any reparative process in the body, angiogenesis becomes an essential component. Anti-angiogenic therapy, in all its guises, arrests repair and causes the hypoxic environment to persist, thus fueling pro-angiogenesis and further development of CNV as a component of aberrant repair. However, we realize that anti-vascular endothelial growth factor therapy preserves vision in patients with age-related macular degeneration, albeit temporarily and therefore, repeated treatment is needed. More importantly, however, anti-angiogenic therapy demonstrates that we can at the very least tolerate neovascular tissue beneath the macula and preserve vision in contrast to our historical approach of total vascular destruction. In this clinical scenario, it may be possible to look beyond anti-angiogenesis if our goal is facilitating submacular repair without destroying the neurosensory retina. Thus, in this situation of neovascular tolerance, it may be timely to consider treatments that facilitate

  3. Public Relations and Marketing.

    Science.gov (United States)

    Savage, Daniel D.

    1987-01-01

    Urges community colleges to adopt pro-active public relations strategies. Examines the role of the public information officer in such areas as coordination of public relations and marketing activities, relations with media, and the development of a comprehensive public relations plan. (AYC)

  4. Angiogenesis-Related Pathways in the Pathogenesis of Ovarian Cancer

    Directory of Open Access Journals (Sweden)

    Aristotle Bamias

    2013-07-01

    Full Text Available Ovarian Cancer represents the most fatal type of gynecological malignancies. A number of processes are involved in the pathogenesis of ovarian cancer, especially within the tumor microenvironment. Angiogenesis represents a hallmark phenomenon in cancer, and it is responsible for tumor spread and metastasis in ovarian cancer, among other tumor types, as it leads to new blood vessel formation. In recent years angiogenesis has been given considerable attention in order to identify targets for developing effective anti-tumor therapies. Growth factors have been identified to play key roles in driving angiogenesis and, thus, the formation of new blood vessels that assist in “feeding” cancer. Such molecules include the vascular endothelial growth factor (VEGF, the platelet derived growth factor (PDGF, the fibroblast growth factor (FGF, and the angiopoietin/Tie2 receptor complex. These proteins are key players in complex molecular pathways within the tumor cell and they have been in the spotlight of the development of anti-angiogenic molecules that may act as stand-alone therapeutics, or in concert with standard treatment regimes such as chemotherapy. The pathways involved in angiogenesis and molecules that have been developed in order to combat angiogenesis are described in this paper.

  5. Community and Public Relations.

    Science.gov (United States)

    Sweet, Harold W.

    This brief presentation describes public relations projects of Dubuque schools to popularize athletics. Among the activities cited which are used to promote community interest in sports events are public school-private school informal matches, talks, swim-a-thons, travel and adventure nights, class banquets with popular speakers, booster clubs,…

  6. Skeletal Muscle Angiogenesis and Its Relation to Insulin Sensitivity

    DEFF Research Database (Denmark)

    Lindqvist, Anna Maria Charlotte K

    in skeletal muscle capillarization (17.0±2.0%; EDL and 20.1±2.4%; soleus muscle) and whole-body insulin sensitivity increased by 24.0±5.0%. In study II obese Zucker rats were transfected with a VEGF-A overexpression vector. The rats were then subjected to 30 days of swim training (over a period of 6 weeks...... mediator of angiogenesis) are reduced in insulin resistant individuals. Exercise training can improve skeletal muscle capillarization and the angiogenic potential and physical activity has also been proven to enhance muscle insulin sensitivity. Increased skeletal muscle capillarization is associated......). After the intervention period, insulin sensitivity was measured as in study I. VEGF-A transfection caused a normalization of the VEGF levels in the muscle. VEGF transfection in combination with training resulted in an increased capillarization (20.7±4.3%) and insulin-stimulated glucose uptake (124...

  7. Teaching Mediated Public Relations.

    Science.gov (United States)

    Kent, Michael L.

    2001-01-01

    Discusses approaches to teaching a mediated public relations course, emphasizing the World Wide Web. Outlines five course objectives, assignments and activities, evaluation, texts, and lecture topics. Argues that students mastering these course objectives will understand ethical issues relating to media use, using mediated technology in public…

  8. Offentlighed og Public Relations

    Directory of Open Access Journals (Sweden)

    Lars Heltoft

    1993-09-01

    Full Text Available Lars Heltoft, der er en af grundlæggerne af Public Relationsuddannelsen på Roskilde Universitetscenter, kaster i artiklen et kritisk blik på den akademiske forskning i feltet public relations. Selv i nyere udgaver af PR-forskningen - af mange anset for "progressive", f.eks. James Grunings og Jon Whites arbejder - ser Lars Heltoft tydelige spor af PR- professionens selvforståelse og legitimationsbehov. Resultatet er, at den "offentlighed", der burde være kernen i den videnskabelige beskæftigelse med public relations, "forsvinder i den blå luft". Han argumenterer for, at Habermas´ forestilling om "offentlighed" stadig institutionaliserer mulig- heden for kritisk diskurs inden for feltet, samtidig med at han i sproghand- lingsteoretisk perspektiv problematiserer Habermas´ legitimationsbegreb, fordi det undtager private virksomheder og organisationer.

  9. Public Relations in the Public Sector

    DEFF Research Database (Denmark)

    Valentini, Chiara

    2013-01-01

    of the Excellence Project in Public Relations and thus applies a research instrument similar to that used in other international scholarly investigations in public relations. The population comprises civil servants working in information and communication activities for Italian public administrations. Findings...... relations. Research limitations: Due to a lack of information on the exact number of public communication officers working in the Italian public administration and a too small number of respondents in one of the respondent groups, it is not possible to draw inferences or general conclusions from...... knowledge on strategic public relations and public communication by offering a specific analysis of the strategic management of information and communication programs in the Italian public administration....

  10. Public relations effectiveness in public health institutions.

    Science.gov (United States)

    Springston, Jeffrey K; Weaver Lariscy, Ruth Ann

    2005-01-01

    This article explores public relations effectiveness in public health institutions. First, the two major elements that comprise public relations effectiveness are discussed: reputation management and stakeholder relations. The factors that define effective reputation management are examined, as are the roles of issues and crisis management in building and maintaining reputation. The article also examines the major facets of stakeholder relations, including an inventory of stakeholder linkages and key audiences, such as the media. Finally, methods of evaluating public relations effectiveness at both the program level and the institutional level are explored.

  11. PubAngioGen: a database and knowledge for angiogenesis and related diseases.

    Science.gov (United States)

    Li, Peng; Liu, Yongrui; Wang, Huan; He, Yuan; Wang, Xue; He, Yundong; Lv, Fang; Chen, Huaqing; Pang, Xiufeng; Liu, Mingyao; Shi, Tieliu; Yi, Zhengfang

    2015-01-01

    Angiogenesis is the process of generating new blood vessels based on existing ones, which is involved in many diseases including cancers, cardiovascular diseases and diabetes mellitus. Recently, great efforts have been made to explore the mechanisms of angiogenesis in various diseases and many angiogenic factors have been discovered as therapeutic targets in anti- or pro-angiogenic drug development. However, the resulted information is sparsely distributed and no systematical summarization has been made. In order to integrate these related results and facilitate the researches for the community, we conducted manual text-mining from published literature and built a database named as PubAngioGen (http://www.megabionet.org/aspd/). Our online application displays a comprehensive network for exploring the connection between angiogenesis and diseases at multilevels including protein-protein interaction, drug-target, disease-gene and signaling pathways among various cells and animal models recorded through text-mining. To enlarge the scope of the PubAngioGen application, our database also links to other common resources including STRING, DrugBank and OMIM databases, which will facilitate understanding the underlying molecular mechanisms of angiogenesis and drug development in clinical therapy.

  12. Quantitative proteomic analysis of mice corneal tissues reveals angiogenesis-related proteins involved in corneal neovascularization.

    Science.gov (United States)

    Shen, Minqian; Tao, Yimin; Feng, Yifan; Liu, Xing; Yuan, Fei; Zhou, Hu

    2016-07-01

    Corneal neovascularization (CNV) was induced in Balb/c mice by alkali burns in the central area of the cornea with a diameter of 2.5mm. After fourteen days, the cornea from one eye was collected for histological staining for CNV examination, while the cornea from the other eye of the same mouse was harvested for proteomic analysis. The label-free quantitative proteomic approach was applied to analyze five normal corneal tissues (normal group mice n=5) and five corresponding neovascularized corneal tissues (model group mice n=5). A total of 2124 proteins were identified, and 1682 proteins were quantified from these corneal tissues. Among these quantified proteins, 290 proteins were significantly changed between normal and alkali burned corneal tissues. Of these significantly changed proteins, 35 were reported or predicted as angiogenesis-related proteins. Then, these 35 proteins were analyzed using Ingenuity Pathway Analysis Software, resulting in 26 proteins enriched and connected to each other in the protein-protein interaction network, such as Lcn-2, αB-crystallin and Serpinf1 (PEDF). These three significantly changed proteins were selected for further Western blotting validation. Consistent with the quantitative proteomic results, Western blotting showed that Lcn-2 and αB-crystallin were significantly up-regulated in CNV model, while PEDF was down-regulated. This study provided increased understanding of angiogenesis-related proteins involved in corneal vascular development, which will be useful in the ophthalmic clinic of specifically target angiogenesis.

  13. Breaking Public Relations' Glass Ceiling.

    Science.gov (United States)

    Dozier, David M.

    1988-01-01

    Suggests that public relations practitioners, especially women practitioners, ought to incorporate program research into daily practice. Considers the shift in public relations from a male-majority to female-majority and the challenges which this shift poses for all public relations practitioners and educators. (MS)

  14. How public relations works: theoretical roots and public relations perspectives

    NARCIS (Netherlands)

    Ihlen, Ø.; van Ruler, B.

    2007-01-01

    Public relations is often studied from a managerial, instrumental perspective or a psychological, behavioral perspective. To understand the role of public relations in building trust or mistrust and to develop - or destroy - a license to operate, it needs also to be studied as a social phenomenon. T

  15. Corporate Culture and Public Relations

    OpenAIRE

    Korolko, Valentyn; Nekrasova, Oksana

    2009-01-01

    Analyzing American publications dealing with the concept of excellent public relations, the authors trace the development of organizational culture and its connection with societal culture, as well as an alyze theoretical and methodological issues of corporate culture and its impact on public relations in an organization. Special attention is paid to some ways in which professional PR departments can be come the source of progressive counter cultures inside the organization capable of changin...

  16. Two Courses in Public Relations.

    Science.gov (United States)

    Phifer, Gregg; Gee, Gerry

    At Florida State University in Tallahassee, 30 students a year are enrolled in the public relations major, beginning with the junior year, so that at any one time there are approximately 60 majors, all of whom have at least a B average. The basic course--PUR 3000, Introduction to Public Relations--enrolls over 150 students a semester in two…

  17. Internationalizing the Public Relations Curriculum.

    Science.gov (United States)

    Taylor, Maureen

    2001-01-01

    Discusses broadening public relations to an international level by incorporating the topics of culture, international practices, and culturally sensitive theory development. Discusses rationale, design, and execution of an undergraduate course in international public relations. Suggests ways to incorporate assignments addressing international…

  18. Evidence that tumor necrosis factor-related apoptosis inducing ligand (TRAIL) inhibits angiogenesis by inducing vascular endothelial cell apoptosis

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Pei-Lin, E-mail: pchen@dal.ca [Department of Pathology, Dalhousie University, Halifax, Nova Scotia (Canada); Easton, Alexander S., E-mail: alexander.easton@dal.ca [Department of Pathology, Dalhousie University, Halifax, Nova Scotia (Canada); Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia (Canada); Division of Neurosurgery, Department of Surgery, Dalhousie University, Halifax, Nova Scotia (Canada)

    2010-01-01

    Tumor necrosis factor (TNF) and its related ligands TNF-related apoptosis inducing ligand (TRAIL) and Fas ligand (FasL) play roles in the regulation of vascular responses, but their effect on the formation of new blood vessels (angiogenesis) is unclear. Therefore, we have examined the effects of these ligands on angiogenesis modeled with primary cultures of human umbilical vein endothelial cells (HUVEC). To examine angiogenesis in the context of the central nervous system, we have also modeled cerebral angiogenesis with the human brain endothelial cell line hCMEC/D3. Parameters studied were bromodeoxyuridine (BrdU) incorporation and cell number (MTT) assay (to assess endothelial proliferation), scratch assay (migration) and networks on Matrigel (tube formation). In our hands, neither TRAIL nor FasL (1, 10, and 100 ng/ml) had an effect on parameters of angiogenesis in the HUVEC model. In hCMEC/D3 cells by contrast, TRAIL inhibited all parameters (10-100 ng/ml, 24 h). This was due to apoptosis, since its action was blocked by the pan-caspase inhibitor zVADfmk (5 x 10{sup -5} mol/l) and TRAIL increased caspase-3 activity 1 h after application. However FasL (100 ng/ml) increased BrdU uptake without other effects. We conclude that TRAIL has different effects on in vitro angiogenesis depending on which model is used, but that FasL is generally ineffective when applied in vitro. The data suggest that TRAIL primarily influences angiogenesis by the induction of vascular endothelial apoptosis, leading to vessel regression.

  19. Impact of Endothelial Microparticles on Coagulation, Inflammation, and Angiogenesis in Age-Related Vascular Diseases

    Directory of Open Access Journals (Sweden)

    Margaret Markiewicz

    2013-01-01

    Full Text Available Endothelial microparticles (EMPs are complex vesicular structures that originate from plasma membranes of activated or apoptotic endothelial cells. EMPs play a significant role in vascular function by altering the processes of inflammation, coagulation, and angiogenesis, and they are key players in the pathogenesis of several vascular diseases. Circulating EMPs are increased in many age-related vascular diseases such as coronary artery disease, peripheral vascular disease, cerebral ischemia, and congestive heart failure. Their elevation in plasma has been considered as both a biomarker and bioactive effector of vascular damage and a target for vascular diseases. This review focuses on the pleiotropic roles of EMPs and the mechanisms that trigger their formation, particularly the involvement of decreased estrogen levels, thrombin, and PAI-1 as major factors that induce EMPs in age-related vascular diseases.

  20. New Media and Public Relations

    OpenAIRE

    Renata Demeterffy Lančić

    2010-01-01

    This article examines the importance of new communication technologies in terms of the development of a pluralistic public sphere and public relations (PR) as one type of communication. In ageneral social context, where the media have lost their primary importance, there is an increasing need for an independent and free communication system. New communication technologies, primarily enabled by the advancement of the Internet, create new development opportunities to communicate to the public. ...

  1. RELATIONS WITH THE PUBLIC VERSUS PUBLIC RELATIONS IN LOCAL PUBLIC ADMINISTRATION

    Directory of Open Access Journals (Sweden)

    Bente Florina Maria

    2010-12-01

    Full Text Available Concomitant with the evolution of society, public relations are socially expressed only together with the explicit articulation of public categories and public organizations, once the individual becomes a citizen whose satisfaction is at the core of the public systems preoccupations, ignoring times long gone when the ordinary citizen and the majority of the public administration representatives couldnt tell apart the concept of public relations from that of relations with the public.

  2. RELATIONS WITH THE PUBLIC VERSUS PUBLIC RELATIONS IN LOCAL PUBLIC ADMINISTRATION

    OpenAIRE

    Bente Florina Maria

    2010-01-01

    Concomitant with the evolution of society, public relations are socially expressed only together with the explicit articulation of public categories and public organizations, once the individual becomes a citizen whose satisfaction is at the core of the public system's preoccupations, ignoring times long gone when the ordinary citizen and the majority of the public administration representatives couldn't tell apart the concept of public relations from that of relations with the public.

  3. Public Relations Writing "Is" Different.

    Science.gov (United States)

    Detweiler, John S.

    Because public relations (PR) writing is different from the writing required in journalism, broadcasting, and advertising, PR practitioners require a background in editing, graphics, planning, campaigning, special events, public opinion, and evaluation beyond that required of a newswriter. Responses to a survey of 38 PR educators across the nation…

  4. Proliferation, angiogenesis and differentiation related markers in compact and follicular-compact thyroid carcinomas in dogs

    Science.gov (United States)

    Pessina, P.; Castillo, V.A.; César, D.; Sartore, I.; Meikle, A.

    2016-01-01

    Immunohistochemical markers (IGF-1, IGF-1R, VEGF, FGF-2, RARα and RXR) were evaluated in healthy canine thyroid glands (n=8) and in follicular-compact (n=8) and compact thyroid carcinomas (n=8). IGF-1, IGF-1R and VEGF expression was higher in fibroblasts and endothelial cells of compact carcinoma than in healthy glands (P < 0.05). Compared to follicular-compact carcinoma, compact carcinoma had higher IGF-1R expression in fibroblasts, and higher FGF-2 expression in endothelial cells (P < 0.05). RARα expression was higher in endothelial cells of compact carcinoma than in those of other groups (P < 0.05). The upregulation of these proliferation- and angiogenesis-related factors in endothelial cells and/or fibroblasts and not in follicular cells of compact carcinoma compared to healthy glands supports the relevance of stromal cells in cancer progression. PMID:28116249

  5. New Media and Public Relations

    Directory of Open Access Journals (Sweden)

    Renata Demeterffy Lančić

    2010-12-01

    Full Text Available This article examines the importance of new communication technologies in terms of the development of a pluralistic public sphere and public relations (PR as one type of communication. In ageneral social context, where the media have lost their primary importance, there is an increasing need for an independent and free communication system. New communication technologies, primarily enabled by the advancement of the Internet, create new development opportunities to communicate to the public. Blogs, web forums, web pages, online-magazines, e-mail lists, chat rooms, social networks, etc. are new forms of public communication, where citizens have equal opportunity to participate in the public sphere, where communication becomes a re-exchange of opinion. Such networks have the potential to be public hearings, a fundamental basis of democracy. These types of media are particularly important in the fi eld of public relations because they improve communication and infl uence social change. The article highlights the signifi cant impact of new communication technologies on public relations and suggests the possibilities of manipulation that result from them. Unlike traditional methods, the new methods are far more subtle. The article concludes that the only possibility to protect computer users is via proper education.

  6. Low Concentration of S100A8/9 Promotes Angiogenesis-Related Activity of Vascular Endothelial Cells: Bridges among Inflammation, Angiogenesis, and Tumorigenesis?

    Directory of Open Access Journals (Sweden)

    Changyou Li

    2012-01-01

    Full Text Available Previous studies showed that several members of the S100A family are involved in neovascularization and tumor development. This study checked whether low concentrations of S100A8 or S100A9 has any effect on the behaviour of vascular endothelial cells. A human umbilical vascular endothelial cell (HUVEC line was used to measure vascular endothelial cell bioactivity related to angiogenesis, such as cell proliferation, migration, and vessel formation. In the low concentration range up to 10 μg/mL, either each alone or in combination, S100A8 and S100A9 proteins promoted proliferation of HUVEC cells in a dose-dependent manner. The presence of both proteins in culture showed additive effects over each single protein. Both proteins enhanced HUVEC cells to migrate across the transwell membrane and to form tube-like structures on the Matrigel surface. When mixed in Matrigel and injected subcutaneously in Balb/c mice, both proteins increased vessel development in the gel plugs. Microarray assay of HUVEC cells treated with 10 μg/mL S100A8 revealed that ribosome pathway, pathogenic Escherichia coli infection pathway, apoptosis, and stress response genes were modulated by S100A8 treatment. We propose that S100A8 and S100A9 proteins from either infiltrating inflammatory cells or tumor cells play an important role in the interplay among inflammation, angiogenesis, and tumorigenesis.

  7. New technologies in public relations

    Directory of Open Access Journals (Sweden)

    Dariusz Tworzydło

    2013-12-01

    Full Text Available The article includes an analysis and presentation of selected examples of communication tools, which are used in companies to create and maintain relationships with internal and external environment. The problems related with definition of public relations were also discussed. The article presents the advantage and negative consequences of the use of modern tools of PR, as well.

  8. Identification of colorectal cancer metastasis markers by an angiogenesis-related cytokine-antibody array

    Institute of Scientific and Technical Information of China (English)

    Ana Abajo; Nerea Bitarte; Ruth Zarate; Valentina Boni; Ines Lopez; Marisol Gonzalez-Huarriz; Javier Rodriguez; Eva Bandres; Jesus Garcia-Foncillas

    2012-01-01

    AIM:To investigate the angiogenesis-related protein expression profile characterizing metastatic colorectal cancer (mCRC) with the aim of identifying prognostic markers.METHODS:The expression of 44 angiogenesissecreted factors was measured by a novel cytokine antibody array methodology.The study evaluated vascular endothelial growth factor (VEGF) and its soluble vascular endothelial growth factor receptor (sVEGFR)-1 protein levels by enzyme immunoassay (EIA) in a panel of 16 CRC cell lines.mRNA VEGF and VEGF-A isoforms were quantified by quantitative reverse-transcription polymerase chain reaction (Q-RT-PCR) and vascular endothelial growth factor receptor (VEGFR)-2 expression was analyzed by flow cytometry.RESULTS:Metastasis-derived CRC cell lines expressed a distinctive molecular profile as compared with those isolated from a primary tumor site.Metastatic CRC cell lines were characterized by higher expression of angiogenin-2 (Ang-2),macrophage chemoattractant proteins-3/4 (MCP-3/4),matrix metalloproteinase-1 (MMP-1),and the chemokines interferon γ inducible T cell α chemoattractant protein (I-TAC),monocyte chemoattractant protein 1-309,and interleukins interleukin (IL)-2 and IL-1α,as compared to primary tumor cell lines.In contrast,primary CRC cell lines expressed higher levels of interferon γ (IFN-γ),insulin-like growth factor-1 (IGF-1),IL-6,leptin,epidermal growth factor (EGF),placental growth factor (PIGF),thrombopoietin,transforming growth factor β1 (TGF-β1) and VEGF-D,as compared with the metastatic cell lines.VEGF expression does not significantly differ according to the CRC cellular origin in normoxia.Severe hypoxia induced VEGF expression up-regulation but contrary to expectations,metastatic CRC cell lines did not respond as much as primary cell lines to the hypoxic stimulus.In CRC primary-derived cell lines,we observed a twofold increase in VEGF expression between normoxia and hypoxia as compared to metastatic cell lines.CRC cell lines express a

  9. Angiogenesis related gene expression profiles of EA.hy926 cells induced by irbesartan: a possible novel therapeutic approach

    Institute of Scientific and Technical Information of China (English)

    MA Cong; LU Xue-chun; LUO Yun; CAO Jian; YANG Bo; GAO Yan; LIU Xian-feng; FAN Li

    2012-01-01

    Background Angiogenesis occurs commonly in various physiological and pathological processes.Improving blood supply through promoting angiogenesis is a novel approach for treating ischemic diseases.Angiotensin Ⅱ type 1 receptor blockers (ARBs) dominate the management of hypertension,but evidence of their role in angiogenesis is contradictory.Here we explored the angiogenic effects of ARBs through characterizing gene expression of the human umbilical vein endothelial cell line EA.hy926 exposed to irbesartan.Methods The human umbilical vein endothelial cell line EA.hy926 was grown for 72 hours after treatment with different concentrations of irbesartan.The cell proliferative capacity was assessed by CCK8 assay at 24,48 and 72 hours.Gene expression levels in EA.hy926 cells responding to irbesartan were measured under optimal proliferation conditions by microarray analysis using Affymetrix U133 plus 2.0.The differential expression of genes involved in angiogenesis was identified through cluster analysis of the resulting microarray data.Quantitative RT-PCR and Western blotting analyses were used to validate differential gene expression related to the angiogenesis process.Results In the 10-4,10-5,10-6 mol/L treatment groups,cell proliferation studies revealed significantly increased proliferation in EA.hy926 cells after 24 hours of irbesartan treatment.However,after 48 and 72 hours of treatment with different concentrations of irbesartan,there was no significant difference in cell proliferation observed in any treatment group.We selected the group stimulated with irbersartan at a concentration of 10-6 mol/L for microarray experiments.Statistical analysis of the microarray data resulted in the identification of 56 gene transcripts whose expression patterns were significantly correlated,negatively or positively,with irbesartan treatment.Cluster analysis showed that these genes were involved in angiogenesis,extracellular stimulus,binding reactions and skeletal system

  10. Inhibition of mTOR reduce Stat3 and PAI related angiogenesis in salivary gland adenoid cystic carcinoma.

    Science.gov (United States)

    Yu, Guang-Tao; Bu, Lin-Lin; Zhao, Yu-Yue; Liu, Bing; Zhang, Wen-Feng; Zhao, Yi-Fang; Zhang, Lu; Sun, Zhi-Jun

    2014-01-01

    Angiogenesis is a complex biological process, which is involved in tumorigenesis and progression. However, the molecular mechanism of underlying angiogenesis remains largely unknown. In this study, we accessed the expression of proteins related angiogenesis by immunohistochemical staining of human tissue microarray which contains 72 adenoid cystic carcinoma (AdCC), 12 pleomorphic adenoma (PMA) and 18 normal salivary gland (NSG) using digital pathological scanner and scoring system. We found that the expression of p-S6(S235/236) (a downstream molecule of mTOR), p-Stat3(T705), PAI, EGFR, and HIF-1α was significantly increased in AdCC as compared with PMA and (or) NSG (p 0.05). Correlation analysis of these proteins revealed that p-S6(S235/236) up-regulates the expression of EGFR/p-Stat3(T705) (p PAI (p PAI associated with angiogenesis (CD34) and proliferation (Ki-67). In vitro, Rapamycin suppressed the expression of p-S6(S235/236), EGFR, p-Stat3(T705), HIF-1α and PAI. Further more, target inhibition of mTOR by rapamycin effectively reduced tumor growth of SACC-83 cells line nude mice xenograft and decreased the expression of p-S6(S235/236), EGFR/p-Stat3(T705) and HIF-1α/PAI. Taken together, these data revealed that mTOR signaling pathway regulates tumor angiogenesis by EGFR/p-Stat3(T705) and HIF-1α/PAI. Inhibition of mTOR by rapamycin could effectively reduced tumor growth. It is likely that mTOR inhibitors may be a potential candidate for treatment of AdCC.

  11. Comparison of angiogenesis-related factor expression in primary tumor cultures under normal and hypoxic growth conditions

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    Brower Stacey L

    2008-07-01

    Full Text Available Abstract Background A localized hypoxic environment occurs during tumor growth necessitating an angiogenic response or tumor necrosis results. Novel cancer treatment strategies take advantage of tumor-induced vascularisation by combining standard chemotherapeutic agents with angiogenesis-inhibiting agents. This has extended the progression-free interval and prolonged survival in patients with various types of cancer. We postulated that the expression levels of angiogenesis-related proteins from various primary tumor cultures would be greater under hypoxic conditions than under normoxia. Methods Fifty cell sources, including both immortalized cell lines and primary carcinoma cells, were incubated under normoxic conditions for 48 hours. Then, cells were either transferred to a hypoxic environment (1% O2 or maintained at normoxic conditions for an additional 48 hours. Cell culture media from both conditions was collected and analyzed via an ELISA-based assay to determine expression levels of 11 angiogenesis-related factors: VEGF, PDGF-AA, PDGF-AA/BB, IL-8, bFGF/FGF-2, EGF, IP-10/CXCL10, Flt-3 ligand, TGF-β1, TGF-β2, and TGF-β3. Results A linear correlation between normoxic and hypoxic growth conditions exists for expression levels of eight of eleven angiogenesis-related proteins tested including: VEGF, IL-8, PDGF-AA, PDGF-AA/BB, TGF-β1, TGF-β2, EGF, and IP-10. For VEGF, the target of current therapies, this correlation between hypoxia and higher cytokine levels was greater in primary breast and lung carcinoma cells than in ovarian carcinoma cells or tumor cell lines. Of interest, patient cell isolates differed in the precise pattern of elevated cytokines. Conclusion As linear correlations exist between expression levels of angiogenic factors under normoxic and hypoxic conditions in vitro, we propose that explanted primary cells may be used to probe the in vivo hypoxic environment. Furthermore, differential expression levels for each sample

  12. Organizational Culture and Public Relations

    OpenAIRE

    Sezgin, Murat; Bulut, Beyza

    2013-01-01

    The organizational culture of is the total sum of the symbols and myths conveying the basic values to the employees. The cultures that belong to organizations develop in time and exert an effect on the workers of the organization in establishing interactions through the opportunities and threats of the environment. The organizational culture which forms an important system of values on the individuals and decisions also plays a role on public relations. Therefore, the individuals should be aw...

  13. Using Crisis Simulations in Public Relations Education

    Science.gov (United States)

    Veil, Shari R.

    2010-01-01

    Objectives: Students will demonstrate research, decision making, team building, and public speaking skills, while applying issues management and crisis communication concepts in a realistic setting. Courses: Introduction to Public Relations, Public Relations Cases, Crisis Communication.

  14. Effects of cloned tumstatin-related and angiogenesis-inhibitory peptides on proliferation and apoptosis of endothelial ceils

    Institute of Scientific and Technical Information of China (English)

    ZHANG Guang-mei; ZHANG Ying-mei; FU Song-bin; LIU Xing-han; FU Xue; YU Yan; ZHANG Zhi-yi

    2008-01-01

    Background Tumstatin is a recently developed endogenous vascular endothelial growth inhibitor that can be applied as an anti-angiogenesis and antineoplastic agent.The study aimed to design and synthesize the small molecular angiogenesis inhibition-related peptide (peptide 21),to replicate the structural and functional features of the active zone of angiogenesis inhibition using tumstatin and to prove that synthesized peptide 21 has a similar activity:specifically inhibiting tumor angiogenesis like tumstatin.Methods Peptide 21 was designed and synthesized using biological engineering technology.To determine its biological action,the human umbilical vein endothelial cell line ECV304,the human ovarian cancer cell line SKOV-3 and the mouse embryo-derived NIH3T3 fibroblasts were used in in vitro experiments to determine the effect of peptide 21 on proliferation of the three cell lines using the MTT test and growth curves.Transmission electron microscopy (TEM) and flow cytometry (FCM) were applied to analyze the peptide 21-induced apoptosis of the three cell lines qualitatively and quantitatively.In animal experiments,tumor models in nude mice subcutaneously grafted with SKOV-3 were used to observe the effects of peptide 21 on tumor weight,size and microvessel density (MVD).To initially investigate the role of peptide 21,the effect of peptide 21 on the expression of vascular endothelial growth factors (VEGFs) by tumor tissue was semi-quantitatively analyzed.Results The in vitro MTT test and growth curves all indicated that cloned peptide 21 could specifically inhibit ECV304 proliferation in a dose-dependent manner (P <0.01);TEM and FCM showed that peptide 21 could specifically induce ECV304 apoptosis (P <0.01).Results of in vivo experiments showed that tumors in the peptide 21 group grew more slowly.The weight and size of the tumors after 21 days of treatment were smaller than those in the control group (P <0.05),with a mean tumor inhibition rate of 67.86%;MVD of

  15. Crisis - Strategic Management in Public Relation

    OpenAIRE

    Saari Ahmad

    2012-01-01

    This is a concept paper to explore the strategic management approaches in public relations during crisis. The main objective of this article is to identify the most effective action plan for Public relation. The review of the strategic management in public relations literature reveals that the relationship between strategic management and public relations is still vague. Four stages were identified in the process of establishing the action plan for public relations and eleven strategic action...

  16. Mesenchymal stem cells from human umbilical cord express preferentially secreted factors related to neuroprotection, neurogenesis, and angiogenesis.

    Directory of Open Access Journals (Sweden)

    Jui-Yu Hsieh

    Full Text Available Mesenchymal stem cells (MSCs are promising tools for the treatment of diseases such as infarcted myocardia and strokes because of their ability to promote endogenous angiogenesis and neurogenesis via a variety of secreted factors. MSCs found in the Wharton's jelly of the human umbilical cord are easily obtained and are capable of transplantation without rejection. We isolated MSCs from Wharton's jelly and bone marrow (WJ-MSCs and BM-MSCs, respectively and compared their secretomes. It was found that WJ-MSCs expressed more genes, especially secreted factors, involved in angiogenesis and neurogenesis. Functional validation showed that WJ-MSCs induced better neural differentiation and neural cell migration via a paracrine mechanism. Moreover, WJ-MSCs afforded better neuroprotection efficacy because they preferentially enhanced neuronal growth and reduced cell apoptotic death of primary cortical cells in an oxygen-glucose deprivation (OGD culture model that mimics the acute ischemic stroke situation in humans. In terms of angiogenesis, WJ-MSCs induced better microvasculature formation and cell migration on co-cultured endothelial cells. Our results suggest that WJ-MSC, because of a unique secretome, is a better MSC source to promote in vivo neurorestoration and endothelium repair. This study provides a basis for the development of cell-based therapy and carrying out of follow-up mechanistic studies related to MSC biology.

  17. MiR-578 and miR-573 as potential players in BRCA-related breast cancer angiogenesis.

    Science.gov (United States)

    Danza, Katia; De Summa, Simona; Pinto, Rosamaria; Pilato, Brunella; Palumbo, Orazio; Merla, Giuseppe; Simone, Gianni; Tommasi, Stefania

    2015-01-01

    The involvement of microRNA (miRNAs), a new class of small RNA molecules, in governing angiogenesis has been well described. Our aim was to investigate miRNA-mediated regulation of angiogenesis in a series of familial breast cancers stratified by BRCA1/2 mutational status in BRCA carriers and BRCA non-carriers (BRCAX). Affymetrix GeneChip miRNA Arrays were used to perform miRNA expression analysis on 43 formalin-fixed paraffin-embedded (FFPE) tumour tissue familial breast cancers (22 BRCA 1/2-related and 21 BRCAX). Pathway enrichment analysis was carried out with the DIANA miRPath v2.0 web-based computational tool, and the miRWalk database was used to identify target genes of deregulated miRNAs. An independent set of 8 BRCA 1/2-related and 11 BRCAX breast tumors was used for validation by Real-Time PCR. In vitro analysis on HEK293, MCF-7 and SUM149PT cells were performed to best-clarify miR-573 and miR-578 role. A set of 16 miRNAs differentially expressed between BRCA 1/2-related and BRCAX breast tumors emerged from the profile analysis. Among these, miR-578 and miR-573 were found to be down-regulated in BRCA 1/2-related breast cancer and associated to the Focal adhesion, Vascular Endothelial Growth Factor (VEGF) and Hypoxia Inducible Factor-1 (HIF-1) signaling pathways. Our data highlight the role of miR-578 and miR-573 in controlling BRCA 1/2-related angiogenesis by targeting key regulators of Focal adhesion, VEGF and HIF-1 signaling pathways.

  18. Angiogenesis and liver fibrosis

    Institute of Scientific and Technical Information of China (English)

    Gülsüm ?zlem Elpek

    2015-01-01

    Recent data indicate that hepatic angiogenesis,regardless of the etiology, takes place in chronic liverdiseases (CLDs) that are characterized by inflammationand progressive fibrosis. Because antiangiogenictherapy has been found to be efficient inthe prevention of fibrosis in experimental models ofCLDs, it is suggested that blocking angiogenesis couldbe a promising therapeutic option in patients withadvanced fibrosis. Consequently, efforts are beingdirected to revealing the mechanisms involved inangiogenesis during the progression of liver fibrosis.Literature evidences indicate that hepatic angiogenesisand fibrosis are closely related in both clinical andexperimental conditions. Hypoxia is a major inducer ofangiogenesis together with inflammation and hepaticstellate cells. These profibrogenic cells stand at theintersection between inflammation, angiogenesis andfibrosis and play also a pivotal role in angiogenesis.This review mainly focuses to give a clear view on therelevant features that communicate angiogenesis withprogression of fibrosis in CLDs towards the-end point ofcirrhosis that may be translated into future therapies.The pathogenesis of hepatic angiogenesis associatedwith portal hypertension, viral hepatitis, non-alcoholicfatty liver disease and alcoholic liver disease are alsodiscussed to emphasize the various mechanisms involvedin angiogenesis during liver fibrogenesis.

  19. Public relations in Europe: A kaleidoscopic picture

    NARCIS (Netherlands)

    van Ruler, A.A.; Vercic, D.; Flodin, B.; Buetschi, G.

    2001-01-01

    Focuses on the Delphi research project, a part of the European Public Relations Body of Knowledge project, which questions the existence of a European authenticity of public relations. Description of the study design; Discussion on public relations as a professional management function; Conclusions.

  20. Teaching Ethics across the Public Relations Curriculum.

    Science.gov (United States)

    Hutchison, Liese L.

    2002-01-01

    Suggests ways of incorporating ethics across the undergraduate public relations curriculum. Reviews current coverage of ethics in public relations principles, writing, cases, and textbooks. Suggests other methods that teachers can use to incorporate ethical pedagogical tools in all public relations courses in an effort to develop students' ethical…

  1. Public Relations for Community/Junior Colleges.

    Science.gov (United States)

    Woodress, Fred A.

    This monograph is a practical manual on public relations (PR) for community and junior colleges, containing numerous suggestions and recommendations for establishing and operating an effective public relations effort while avoiding PR pitfalls. An overview of the history of public relations in academe, the rationale underlying today's PR programs…

  2. Targeting Vascular Endothelial Growth Factor Receptor 2 and Protein Kinase D1 Related Pathways by a Multiple Kinase Inhibitor in Angiogenesis and Inflammation Related Processes In Vitro

    OpenAIRE

    Attila Varga; Pál Gyulavári; Zoltán Greff; Krisztina Futosi; Tamás Németh; Laura Simon-Szabó; Krisztina Kerekes; Csaba Szántai-Kis; Diána Brauswetter; Márton Kokas; Gábor Borbély; Anna Erdei; Attila Mócsai; György Kéri; Tibor Vántus

    2015-01-01

    Emerging evidence suggests that the vascular endothelial growth factor receptor 2 (VEGFR2) and protein kinase D1 (PKD1) signaling axis plays a critical role in normal and pathological angiogenesis and inflammation related processes. Despite all efforts, the currently available therapeutic interventions are limited. Prior studies have also proved that a multiple target inhibitor can be more efficient compared to a single target one. Therefore, development of novel inflammatory pathway-specific...

  3. Angiogenesis-Related Biomarkers in Patients with Alcoholic Liver Disease: Their Association with Liver Disease Complications and Outcome

    Directory of Open Access Journals (Sweden)

    Beata Kasztelan-Szczerbinska

    2014-01-01

    Full Text Available Angiogenesis is believed to be implicated in the pathogenesis of alcoholic liver disease (ALD. We aimed to explore the usefulness and accuracy of plasma angiogenic biomarkers for noninvasive evaluation of the severity of liver failure and ALD outcome. One hundred and forty-seven patients with ALD were prospectively enrolled and assessed based on their (1 gender, (2 age, (3 severity of liver dysfunction according to the Child-Turcotte-Pugh and MELD scores, and (4 the presence of ALD complications. Plasma levels of vascular endothelial growth factor (VEGF-A and angiopoietins 1 and 2 (Ang1 and Ang2 were investigated using ELISAs. Multivariable logistic regression was applied in order to select independent predictors of advanced liver dysfunction and the disease complications. Significantly higher concentrations of Ang2 and VEGF-A in ALD patients as compared to controls were found. There was no difference in Ang1 levels in both groups. A positive correlation of Ang2 levels with INR (Rho 0.66; P<0.0001 and its inverse correlation with plasma albumin levels (Rho –0.62; P<0.0001 were found. High Ang2 concentrations turned out to be an independent predictor of severe liver dysfunction, as well as hepatic encephalopathy and renal impairment. Ang2 possessed the highest diagnostic and prognostic potential among three studied angiogenesis-related molecules.

  4. Public Relations Ethics in Information Management

    Directory of Open Access Journals (Sweden)

    Hrvoje Jakopović

    2013-06-01

    Full Text Available Public relations is involved in all communication between an organization and the public. In the contemporary world, PR practitioners have become the facilitators of information. Information and communication technology (ICT have imposed new rules in the field of public relations. Communication strategy and information management have become crucial parts of modern public relations. People change their habits with regard to the consumption of traditional and new media. The challenges imposed by the development of information and communication technology are also related to understanding the new information society. For that reason information ethics deals with the ethical implications of dissemination, use, development and safety of information. Public relations follow new information and communication trends, and they need to build firm ethical principles for the age of information. The author examines the ethical implications of the framing concept in public relations.

  5. PUBLIC RELATIONS AS AN INFORMATION PROCESS PHENOMENON

    Directory of Open Access Journals (Sweden)

    TKACH L. M.

    2016-06-01

    Full Text Available Formulation of the problem. If public relations as a phenomenon of information management are examined, we deal with the question of knowledge content and nature of relationship of PR with environment, ability to manage the perception and attitude of people to events in the environment; ensure priority of information over other resources. Goal. To investigate the concept of "public relations" of foreign and domestic experts; consider the typology of the public and the "laws" of public opinion; define the basic principles according to which relations with public should be built, and to identify PR activities as a kind of social communication. Conclusions. Public relations on the basis of advanced information and communication technologies create fundamentally new opportunities for information control and influence on public consciousness.

  6. Public Relations and Neo-institutional theory

    OpenAIRE

    Fredriksson, Magnus; Pallas, Josef; Wehmeier, Stefan

    2013-01-01

    This special section seeks to enrich research on the field by using neo-institutional theory to describe, explain and understand the activities, processes and dynamics of public relations. By this we open up for a wider understanding of public relations, its preconditions, its performances and its consequences for shaping the social. We argue that public relations could be analyzed as an institutionalized practice with certain set of governing mechanisms including taken-for-granted activities...

  7. Angiogenesis related genes NOS3, CD14, MMP3 and IL4R are associated to VEGF gene expression and circulating levels in healthy adults

    OpenAIRE

    Saleh, Abdelsalam; Stathopoulou, Maria G.; Dadé, Sébastien; Ndiaye, Ndeye Coumba; Azimi-Nezhad, Mohsen; Murray, Helena; Masson, Christine; Lamont, John; Fitzgerald, Peter; Visvikis-Siest, Sophie

    2015-01-01

    Background Vascular endothelial growth factor (VEGF) plays a key role in angiogenesis. The aim was to assess the genetic connections between the angiogenesis-related NOS3, CD14, MMP3, IL4R, IL4 genes and VEGF expression and plasma levels. Methods The associations between VEGF plasma levels with the polymorphisms of NOS3, CD14, MMP3, IL4R, and IL4 were assessed in 403 healthy unrelated adults. The epistatic and environmental interactions were explored, including four VEGF-related polymorphisms...

  8. Pension System Related Public Politics

    Directory of Open Access Journals (Sweden)

    LIVIU RADU

    2015-05-01

    Full Text Available This paper aims to find some answers regarding the long term sustainability of the pension system. Romania’s pension system originates from the invalidity insurances and pension system designed by the German cancellor Otto Eduard Leopold von Bismark in 1889. From a European perspective, Romania has to fill an obvious gap regarding the reformation of the national public pension system. International experience, particularly of the last 130 years, indicates that, in actuality, multiple pension systems have been put into function in most of the world’s countries and which are diferenciated by some elements (organizing and managing the system, defyning pension rights, method of forming the resources, the pension’s level rapported to the average income etc. and after the eficacity degree dependent on internal influences, social, economic and demographic environment, and last but not least by the political factor.

  9. Public relations metrics: research and evaluation

    NARCIS (Netherlands)

    van Ruler, B.; Tkalac Verčič, A.; Verčič, D.

    2008-01-01

    Responding to the increasing need in academia and the public relations profession, this volume presents the current state of knowledge in public relations measurement and evaluation. The book brings together ideas and methods that can be used throughout the world, and scholars and practitioners from

  10. Transformative Learning Approaches for Public Relations Pedagogy

    Science.gov (United States)

    Motion, Judy; Burgess, Lois

    2014-01-01

    Public relations educators are frequently challenged by students' flawed perceptions of public relations. Two contrasting case studies are presented in this paper to illustrate how socially-oriented paradigms may be applied to a real-client project to deliver a transformative learning experience. A discourse-analytic approach is applied within the…

  11. Political public relations in the European Union

    DEFF Research Database (Denmark)

    Valentini, Chiara

    2013-01-01

    This article examines the state of political public relations in the European Union by specifically focusing on reputation management and relationship management. Its arguments are based on a theoretical review of the literature of political public relations, reputation and relationship managemen...... to a political context. The nature of the analysis is exploratory rather than definitive, and specific investigations are needed to thoroughly explore and better theorize political reputation and relationship management in various political contexts.......This article examines the state of political public relations in the European Union by specifically focusing on reputation management and relationship management. Its arguments are based on a theoretical review of the literature of political public relations, reputation and relationship management......, and EU communication. The article suggests an in-depth examination of the nature of some of the EU’s major problems in political public relations, and contributes to a more nuanced understanding of the possibilities and limitations of applying reputation and relationship management constructs...

  12. Analysis of angiogenesis related factors in glioblastoma, peritumoral tissue and their derived cancer stem cells.

    Science.gov (United States)

    D'Alessio, Alessio; Proietti, Gabriella; Lama, Gina; Biamonte, Filippo; Lauriola, Libero; Moscato, Umberto; Vescovi, Angelo; Mangiola, Annunziato; Angelucci, Cristiana; Sica, Gigliola

    2016-11-29

    The formation of new blood vessels represents a crucial event under both physiological and pathological circumstances. In this study, we evaluated by immunohistochemistry, and/or Western blotting and/or quantitative real time-PCR the expression of HIF1α, HIF2α, VEGF, VEGFR1 and VEGFR2 in surgical glioblastoma multiforme (GBM) and peritumoral tissue samples obtained from 50 patients as well as in cancer stem cells (CSCs) isolated from GBM (GCSCs) and peritumoral tissue (PCSCs) of 5 patients. We also investigated the contribution of both GCSCs and PCSCs on the behavior of endothelial cells (ECs) in vitro. Immunohistochemistry demonstrated the expression of angiogenesis markers in both GBM and peritumoral tissue. In addition, in vitro tube formation assay indicated that both GCSCs and PCSCs stimulate EC proliferation as well as tube-like vessel formation. An increased migration aptitude was mainly observed when ECs were cultured in the presence of GCSCs rather than in the presence of PCSCs. These findings suggest that relevant neoangiogenetic events may occur in GBM. In particular, VEGF/VEGFR co-expression in PCSCs leads to hypothesize the involvement of an autocrine signaling. Moreover, our results suggest that both GCSCs and PCSCs own the skill of activating the "angiogenic switch" and the capability of modulating EC behavior, indicating that both cell types are either responsive to angiogenic stimuli or able to trigger angiogenic response. Together with our previous findings, this study adds a further piece to the challenging puzzle of the characterization of peritumoral tissue and of the definition of its real role in GBM pathophysiology.

  13. Public Relations for the School Librarian.

    Science.gov (United States)

    Boardman, Edna M.; And Others

    1991-01-01

    Includes seven articles that deal with public relations (PR) for school librarians. Highlights include image problems librarians face and suggestions for promoting more positive images; PR plans that focus on the past, present, and future; nontraditional ways that librarians can attract students and teachers; publicity techniques; and media center…

  14. Hiring Criteria of Public Relations Employers.

    Science.gov (United States)

    Wilcox, Dennis L.

    A poll of 90 top-level public relations executives in the San Francisco Bay area generated 65 usable responses to a questionnaire about their hiring practices and about the skills, educational background, and practical experiences that they seek in job applicants. The data from the questionnaire show that the ideal applicant for a public relations…

  15. Analisis Framing dalam Riset Public Relations

    OpenAIRE

    NARAYANA MAHENDRA PRASTYA

    2016-01-01

    This paper aims to give description about how to use frame analysis in Public Relations (PR) research. The author use two framing models: Entman and Pan & Kosicki. The object is organization official statement about particular issue. Frame analysis method rarely used in Public Relations research. This methods commonly use in journalism study, to analyse the news in media. Meanwhile, the key word of framing is the social construction of reality. Organization can make social cons...

  16. Creative communication in public relations activities

    Directory of Open Access Journals (Sweden)

    Dalibor Jakus

    2013-12-01

    Full Text Available This article discusses several approaches to new waves of public relations. Emphasis is given to the creative impulse since many public relations professionals are less familiar with it than other forms of communication. Five criteria are suggested for structuring creative communications: 1. learning how to be a good storyteller; 2. visual communication is the content that could increasingly build strong relationships with audiences; 3. the PR practitioner’s challenge is to evaluate what people are discussing and identify the recurring issues in their marketplace; 4. recognizing that local is new global; and 5. predicate that PR is constantly changing. People who work in public relations possess the skill of offering arguments that will convince the people themselves of something. However, these skills can be offered in traditional or creative forms of expression. If we define public relations as the management of an organization’s communication with its public, then we are referring to the traditional dimension of public relations, the basis and ultimate goal of which are to cultivate relationships with the participants of the process in order to obtain support and to build trust and reputation.

  17. Oxalomalate reduces expression and secretion of vascular endothelial growth factor in the retinal pigment epithelium and inhibits angiogenesis: Implications for age-related macular degeneration

    Directory of Open Access Journals (Sweden)

    Sung Hwan Kim

    2016-12-01

    Full Text Available Clinical and experimental observations indicate a critical role for vascular endothelial growth factor (VEGF, secreted by the retinal pigment epithelium (RPE, in pathological angiogenesis and the development of choroidal neovascularization (CNV in age-related macular degeneration (AMD. RPE-mediated VEGF expression, leading to angiogenesis, is a major signaling mechanism underlying ocular neovascular disease. Inhibiting this signaling pathway with a therapeutic molecule is a promising anti-angiogenic strategy to treat this disease with potentially fewer side effects. Oxalomalate (OMA is a competitive inhibitor of NADP+-dependent isocitrate dehydrogenase (IDH, which plays an important role in cellular signaling pathways regulated by reactive oxygen species (ROS. Here, we have investigated the inhibitory effect of OMA on the expression of VEGF, and the associated underlying mechanism of action, using in vitro and in vivo RPE cell models of AMD. We found that OMA reduced the expression and secretion of VEGF in RPE cells, and consequently inhibited CNV formation. This function of OMA was linked to its capacity to activate the pVHL-mediated HIF-1α degradation in these cells, partly via a ROS-dependent ATM signaling axis, through inhibition of IDH enzymes. These findings reveal a novel role for OMA in inhibiting RPE-derived VEGF expression and angiogenesis, and suggest unique therapeutic strategies for treating pathological angiogenesis and AMD development.

  18. Analisis Framing dalam Riset Public Relations

    Directory of Open Access Journals (Sweden)

    NARAYANA MAHENDRA PRASTYA

    2016-12-01

    Full Text Available This paper aims to give description about how to use frame analysis in Public Relations (PR research. The author use two framing models: Entman and Pan & Kosicki. The object is organization official statement about particular issue. Frame analysis method rarely used in Public Relations research. This methods commonly use in journalism study, to analyse the news in media. Meanwhile, the key word of framing is the social construction of reality. Organization can make social construction of realty in their official statement. In acacemic term, frame analysis in PR research is useful to know how organization positioned themselves in particular situation. Other benefit is use to evaluat whether the organization frame is conformable with the public opinion or agenda setting media or not. In practical term, frame analysis give benefit for PR practitioner to create the message that can be undserstood by public, also give positive image for organization.

  19. Effect of corporate culture on public relations activities interaction between public relations and corporate culture

    OpenAIRE

    DEMİRCİ, FETTAHOĞLU Sevgin

    2010-01-01

    Public relations units which were giving support to efforts to develop and expand a common corporate culture have evolved into units playing an effective role in decision-making mechanisms. Public relations experts should be familiar with and be capable of applying the components of corporate culture. The purpose of this paper is to emphasize the importance of public relations activities which is undeniably crucial for developing the concept of corporate culture and to expose its strengths. I...

  20. Using public relations for a dental practice.

    Science.gov (United States)

    Richards, D

    1998-07-01

    Public relations is a way of marketing a dental practice through the media and directly to potential patients without purchasing advertising time or space. Well-written press releases and follow-up phone calls targeted to the specific audience of various media outlets can result in stories that are worth more than purchased advertising. One key to successfully communicating to others through public relations is straightforward writing. The following article not only covers the variety of opportunities available to a dental practice through PR, it also serves as an excellent example of the style of writing that should be used for PR communications.

  1. miR-126 Regulation of Angiogenesis in Age-Related Macular Degeneration in CNV Mouse Model

    Directory of Open Access Journals (Sweden)

    Lei Wang

    2016-06-01

    Full Text Available miR-126 has recently been implicated in modulating angiogenic factors in vascular development. Understandings its biological significance might enable development of therapeutic interventions for diseases like age-related macular degeneration (AMD. We aimed to determine the role of miR-126 in AMD using a laser-induced choroidal neovascularization (CNV mouse model. CNV was induced by laser photocoagulation in C57BL/6 mice. The CNV mice were transfected with scrambled miR or miR-126 mimic. The expression of miR-126, vascular endothelial growth factor-A (VEGF-A, Kinase insert domain receptor (KDR and Sprouty-related EVH1 domain-containing protein 1 (SPRED-1 in ocular tissues were analyzed by qPCR and Western blot. The overexpression effects of miR-126 were also proven on human microvascular endothelial cells (HMECs. miR-126 showed a significant decrease in CNV mice (p < 0.05. Both mRNA and protein levels of VEGF-A, KDR and SPRED-1 were upregulated with CNV; these changes were ameliorated by restoration of miR-126 (p < 0.05. CNV was reduced after miR-126 transfection. Transfection of miR-126 reduced the HMECs 2D-capillary-like tube formation (p < 0.01 and migration (p < 0.01. miR-126 has been shown to be a negative modulator of angiogenesis in the eye. All together these results high lights the therapeutic potential of miR-126 suggests that it may contribute as a putative therapeutic target for AMD in humans.

  2. Angiogenesis-related genes and thalidomide teratogenesis in humans: an approach on genetic variation and review of past in vitro studies.

    Science.gov (United States)

    Kowalski, Thayne Woycinck; Fraga, Lucas Rosa; Tovo-Rodrigues, Luciana; Sanseverino, Maria Teresa Vieira; Hutz, Mara Helena; Schuler-Faccini, Lavínia; Vianna, Fernanda Sales Luiz

    2017-02-01

    Thalidomide embryopathy (TE) has affected more than 10,000 babies worldwide. The hypothesis of antiangiogenesis as the teratogenic mechanism of thalidomide has been investigated in several experimental models; but, in humans, it has only been accessed by in vitro studies. Here, we hypothesized the effect of thalidomide upon angiogenesis-related molecules or proteins, previously identified in human embryonic cells, through the in silico STRING-tool. We also investigated ten polymorphisms in angiogenesis-related genes in 38 Brazilian TE individuals and 136 non-affected Brazilians. NOS2, PTGS2, and VEGFA polymorphisms were chosen for genotyping. The STRING-tool suggested nitric oxide and β-catenin as the central angiogenesis-related molecules affected by thalidomide's antiangiogenic property. We did not identify a significant difference of allelic, genotypic or haplotypic frequencies between the groups. We could not predict a risk allele or a protective one for TE in NOS2, PTGS2, or VEGFA, although other genes should be analyzed in larger samples. The role of nitric oxide and β-catenin must be further evaluated, regarding thalidomide teratogenesis complex etiology.

  3. Plug into PR. NJLA Public Relations Handbook.

    Science.gov (United States)

    New Jersey Library Association, Trenton.

    A guide to using public relations techniques to promote both everyday services and special events at libraries, this handbook describes and suggests ways to use library displays; in-house printing; the local media, e.g., radio spots and cable television; library programs; marketing and promotion; and fundraising, including the formation of a…

  4. The Library Public Relations Recipe Book.

    Science.gov (United States)

    Moran, Irene E., Ed.

    The 17 short pieces in this guide advise librarians how to enhance the profile of their organizations through increased interest in the media and more visible involvement in the community, and how to address budgeting, planning, and evaluating a public relations program. Fourteen rules of thumb for preparing and using news releases are described…

  5. Principals' Perceptions of School Public Relations

    Science.gov (United States)

    Morris, Robert C.; Chan, Tak Cheung; Patterson, Judith

    2009-01-01

    This study was designed to investigate school principals' perceptions on school public relations in five areas: community demographics, parental involvement, internal and external communications, school council issues, and community resources. Findings indicated that principals' concerns were as follows: rapid population growth, change of…

  6. School Public Relations: Personnel Roles and Responsibilities

    Science.gov (United States)

    Norton, M. Scott

    2008-01-01

    This article emphasizes the paramount importance of the human resources function in the school system--specifically, in the implementation of an effective school public relations program and in the quality of leadership given by the administrators and the professional and classified staffs. The article submits that school administrators at every…

  7. Angiogenesis in vestibular schwannomas

    DEFF Research Database (Denmark)

    Møller, Martin Nue; Werther, Kim; Nalla, Amarnadh;

    2010-01-01

    Vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) are potent mediators of tumor angiogenesis. It has been demonstrated that vestibular schwannoma VEGF expression correlates with tumor growth pattern, whereas knowledge on the expression of MMPs is lacking. This study t...... targets the angiogenic process by investigation of tumor expression of MMP-2, MMP-9, and tissue inhibitors of metalloproteinase (TIMP)-1. A possible correlation with gender, patient age, symptom duration, tumor size, and the absolute and relative growth rate is explored....

  8. Hypoxia inducible factor-1-alpha (HIF-1α) is related to both angiogenesis and inflammation in rheumatoid arthritis

    NARCIS (Netherlands)

    Brouwer, Elisabeth; Gouw, Annette S.H.; Posthumus, Marcel D.; Van Leeuwen, Miek A.; Boerboom, Alexander L.; Bijzet, Johan; Bos, Reinhard; Limburg, Piet C.; Kallenberg, Cees G.M.; Westra, Johanna

    2009-01-01

    Objectives: Despite the important role of the transcription factor HIF-1α in angiogenesis and inflammation, only a few studies on HIF-1α expression have been performed in RA patients. The aim of the present study was to identify the layer in synovial tissue of RA patients where HIF1α is expressed an

  9. Hypoxia inducible factor-1-alpha (HIF-1 alpha) is related to both angiogenesis and inflammation in rheumatoid arthritis

    NARCIS (Netherlands)

    Brouwer, E.; Gouw, A. S. H.; Posthumus, M. D.; van Leeuwen, M. A.; Boerboom, A. L.; Bijzet, J.; Limburg, P. C.; Kallenberg, C. G. M.; Westra, J.; Bos, R

    2009-01-01

    Objectives Despite the important role of the transcription factor HIF-1 alpha in angiogenesis and inflammation, only a few studies on HIF-1 alpha expression have been performed in RA patients. The aim of the present study was to identify the layer in synovial tissue of RA patients where HIF1 alpha i

  10. Standards for Educational Public Relations and Communications Professionals.

    Science.gov (United States)

    Chappelow, Marsha A.

    2003-01-01

    Describes National School Public Relations Association standards for school public relations and communications professionals and program. Includes reactions and comments about new Association standards from seven superintendents and four school public-relations professionals. (PKP)

  11. Dickkopf‑related protein 1 induces angiogenesis by upregulating vascular endothelial growth factor in the synovial fibroblasts of patients with temporomandibular joint disorders.

    Science.gov (United States)

    Jiang, Sheng-Jun; Li, Wei; Li, Ying-Jie; Fang, Wei; Long, Xing

    2015-10-01

    Angiogenesis has an important role in the progression of temporomandibular joint disorders (TMD). The aim of the present study was to explore the association between dickkopf‑related protein 1 (DKK‑1) and angiogenesis in TMD. The expression levels of DKK‑1 and vascular endothelial growth factor (VEGF) were quantified by an ELISA assay of the synovial fluid from patients with TMD. The correlation between DKK‑1 and VEGF was analyzed by Pearson correlation test. Synovial fibroblasts were isolated from patients with TMD and were subsequently treated with recombinant human DKK‑1, anti‑DKK‑1 antibody, hypoxia inducible factor‑1α (HIF‑1α), or small interfering RNA (siRNA). The expression levels of DKK‑1, HIF‑1α, and VEGF were subsequently quantified. The present study also investigated the effects of DKK‑1 on the migration of human umbilical vein endothelial cells (HUVEC). Increased expression levels of DKK‑1 were concordant with increased expression levels of VEGF in the synovial fluid from patients with TMD. In the synovial fibroblasts, DKK‑1 increased the expression levels of VEGF, and promoted HIF‑1α nuclear localization. In addition, DKK‑1 induced HUVEC migration, and HIF‑1α siRNA inhibited DKK‑1‑induced cell migration. The results of the present study indicate that DKK‑1 is associated with angiogenesis in the synovial fluid of patients with TMD. Furthermore, HIF‑1α may be associated with DKK‑1‑induced HUVEC activation.

  12. ALK1 signalling analysis identifies angiogenesis related genes and reveals disparity between TGF-β and constitutively active receptor induced gene expression

    Directory of Open Access Journals (Sweden)

    Hafner Mathias

    2006-04-01

    Full Text Available Abstract Background TGF-β1 is an important angiogenic factor involved in the different aspects of angiogenesis and vessel maintenance. TGF-β signalling is mediated by the TβRII/ALK5 receptor complex activating the Smad2/Smad3 pathway. In endothelial cells TGF-β utilizes a second type I receptor, ALK1, activating the Smad1/Smad5 pathway. Consequently, a perturbance of ALK1, ALK5 or TβRII activity leads to vascular defects. Mutations in ALK1 cause the vascular disorder hereditary hemorrhagic telangiectasia (HHT. Methods The identification of ALK1 and not ALK5 regulated genes in endothelial cells, might help to better understand the development of HHT. Therefore, the human microvascular endothelial cell line HMEC-1 was infected with a recombinant constitutively active ALK1 adenovirus, and gene expression was studied by using gene arrays and quantitative real-time PCR analysis. Results After 24 hours, 34 genes were identified to be up-regulated by ALK1 signalling. Analysing ALK1 regulated gene expression after 4 hours revealed 13 genes to be up- and 2 to be down-regulated. Several of these genes, including IL-8, ET-1, ID1, HPTPη and TEAD4 are reported to be involved in angiogenesis. Evaluation of ALK1 regulated gene expression in different human endothelial cell types was not in complete agreement. Further on, disparity between constitutively active ALK1 and TGF-β1 induced gene expression in HMEC-1 cells and primary HUVECs was observed. Conclusion Gene array analysis identified 49 genes to be regulated by ALK1 signalling and at least 14 genes are reported to be involved in angiogenesis. There was substantial agreement between the gene array and quantitative real-time PCR data. The angiogenesis related genes might be potential HHT modifier genes. In addition, the results suggest endothelial cell type specific ALK1 and TGF-β signalling.

  13. Public relations i et overkommunikeret samfund

    Directory of Open Access Journals (Sweden)

    Jesper Højbjerg Christensen

    1993-09-01

    Full Text Available Vi har aldrig før været så overfodret med kommunikation. Jesper Højbjerg Christensen, direktør for Advice Ledelses- og Kommuni- kationsrådgivning A/S, diskuterer i artiklen som praktiker med kom- munikationsreoretisk baggrund, hvordan det kan sikres, at man inden for kommunikations- og public relations-branchen ikke bare kommunikerer som propagandamaskiner - mere og mere - men hellere går i dialog og kommunikerer mindre, og bedre. Han peger på, at vi i fremtiden, bl.a. takket være sammenhængne mellem høj uddannelse og avanceret teknologi, får mulighed for at udfolde mere symmetriske kommunikationsformer og konsensus-funderet dialog. Som sit bidrag til at udrydde forvirringen om, hvad public relation egentlig er, opstiller han - uden større tiltro til, at man kan skabe en "teori" om PR - ud fra praksis fire forskellige måder at dyrke public relations på.

  14. Dietary proteins and angiogenesis.

    Science.gov (United States)

    Medina, Miguel Ángel; Quesada, Ana R

    2014-01-17

    Both defective and persistent angiogenesis are linked to pathological situations in the adult. Compounds able to modulate angiogenesis have a potential value for the treatment of such pathologies. Several small molecules present in the diet have been shown to have modulatory effects on angiogenesis. This review presents the current state of knowledge on the potential modulatory roles of dietary proteins on angiogenesis. There is currently limited available information on the topic. Milk contains at least three proteins for which modulatory effects on angiogenesis have been previously demonstrated. On the other hand, there is some scarce information on the potential of dietary lectins, edible plant proteins and high protein diets to modulate angiogenesis.

  15. What Cultural Values Influence American Public Relations Practitioners?

    Science.gov (United States)

    Vasquez, Gabriel M.; Taylor, Maureen

    1999-01-01

    Examines the role of culture as a key variable in public relations research and practice. Finds (1) American practitioners continue to practice one-way models of public relations; and (2) public relations practitioners who have collectivistic values tend to practice two-way models of public relations. Discusses implications for theory and…

  16. Political Communication: Contributions to the Study of Public Relations.

    Science.gov (United States)

    Stacks, Don W.

    Political communication has influenced greatly the study of modern public relations. The development of modern public relations can be traced back to the Ancients of Greece. The definition of "political communication" when applied to public relations is typically corporate in nature. That is, public relations defines the role of…

  17. Public Relations: A Comprehensive Bibliography; Articles and Books on Public Relations, Communication Theory, Public Opinion, and Propaganda, 1964-1972.

    Science.gov (United States)

    Bishop, Robert L., Comp.

    This bibliography lists and sometimes annotates approximately 4,000 books, articles, and speeches about or related to public relations. The book contains sections on such subjects as advertising, agriculture, automation, banking, books, business, chemical industry, computers, consumer and consumer relations, corporate image, ecology, education,…

  18. Public Relations between Occupation and Profession – Attempts at Regulating Public Relations

    Directory of Open Access Journals (Sweden)

    Božo Skoko

    2012-06-01

    Full Text Available This paper is concerned with the regulation and the professionalization of occupations in public relations. It analyzes the role of professional, national associations in the professionalization process, providing an overview of these organizations in various countries around the world. The authors identify countries with no regulation (for instance, Italy, countries with some legal regulations (for instance, Brazil and countries that have adopted self-regulation models (for instance, USA and South Africa. The authors point out the advantages and drawbacks of each regulation model and their impact on the development and professionalization of the occupation. Namely, in countries in which public relations are defined by law, public relations experts have guaranteed positions in society; however, they enjoy a negative public perception. In self-regulatory models, a significant number of experts are not covered by membership in organizations. Consequently, their behavior is not governed by any set of established professional obligations. Furthermore, countries with no clear professional regulation have enabled mass engagement in public relations; however, there are no criteria for professional advancement and affirmation. The issue of regulation in transition countries has shown itself to be a relatively unarticulated concept that can be expected to acquire greater definition with further professionalization of the occupation, a key role that must be played by professional associations.

  19. The Academic Preparation Recommended by Public Relations Employers.

    Science.gov (United States)

    Wakefield, Gay; Cottone, Laura Perkins

    Questionnaires were mailed to 261 agencies involved in public relations and publicity services, 56 agencies involved in advertising, and public relations directors of 183 corporations and other nonagency organizations in order to determine the knowledge and skill areas important to agency and organizational public relations employers. In an effort…

  20. Student-Created Public Relations for Gifted Education.

    Science.gov (United States)

    Bisland, Amy

    2003-01-01

    This article discusses the benefits of student participation in a gifted public relations campaign, including creating public support for gifted programming and developing leadership skills. Steps for developing a formal unit of instruction on public relations are described, along with ideas for public relations activities. (Contains references.)…

  1. Public Relations Writing Needs Multi-Media Approach.

    Science.gov (United States)

    Harrison, S. L.

    1989-01-01

    Argues that the public relations and advertising disciplines are inextricably linked and should be related in a cohesive writing sequence. Emphasizes that beginning advertising and public relations students should develop their news writing skills. (MM)

  2. Global Tumor RNA Expression in Early Establishment of Experimental Tumor Growth and Related Angiogenesis following Cox-Inhibition Evaluated by Microarray Analysis

    Directory of Open Access Journals (Sweden)

    Kent Lundholm

    2007-01-01

    Full Text Available Altered expression of COX-2 and overproduction of prostaglandins, particularly prostaglandin E2, are common in malignant tumors. Consequently, non-steroidal anti-inflammatory drugs (NSAIDs attenuate tumor net growth, tumor related cachexia, improve appetite and prolong survival. We have also reported that COX-inhibition (indomethacin interfered with early onset of tumor endothelial cell growth, tumor cell proliferation and apoptosis. It is however still unclear whether such effects are restricted to metabolic alterations closely related to eicosanoid pathways and corresponding regulators, or whether a whole variety of gene products are involved both up- and downstream effects of eicosanoids. Therefore, present experiments were performed by the use of an in vivo, intravital chamber technique, where micro-tumor growth and related angiogenesis were analyzed by microarray to evaluate for changes in global RNA expression caused by indomethacin treatment. Indomethacin up-regulated 351 and down-regulated 1852 genes significantly (p < 0.01; 1066 of these genes had unknown biological function. Genes with altered expression occurred on all chromosomes. Our results demonstrate that indomethacin altered expression of a large number of genes distributed among a variety of processes in the carcinogenic progression involving angiogenesis, apoptosis, cell-cycling, cell adhesion, inflammation as well as fatty acid metabolism and proteolysis. It remains a challenge to distinguish primary key alterations from secondary adaptive changes in transcription of genes altered by cyclooxygenase inhibition.

  3. Interdiscursive collaboration in public relations contexts

    Directory of Open Access Journals (Sweden)

    Vijay K. Bhatia

    2013-04-01

    Full Text Available Interdiscursive collaborative construction of professional genres (Bhatia, 2004 & 2010; Bremner, 2006; Smart, 2006 within the framework of “communities of practice” (Lave & Wenger, 1991 can be viewed as a useful instrument for developing writing expertise to initiate novice writers into the conventions of corporate writing. Drawing on evidence from public relations (PR writing contexts in Hong Kong, the paper focuses on the dynamics of participation in collaborative PR practice and on the deconstruction of the collaborative process as evidenced in the deconstruction of various drafts (from brainstorming to the final product and through the perceptions of some of the key PR practitioners in the industry. The paper will have implications for our understanding of interdiscursivity in genre theory (Bhatia, 2010 and for the collaborative writing process within the academy as well as in the workplace.

  4. Functional inhibition of UQCRB suppresses angiogenesis in zebrafish

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Yoon Sun; Jung, Hye Jin [Chemical Genomics National Research Laboratory, Department of Biotechnology, Translational Research Center for Protein Function Control, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749 (Korea, Republic of); Seok, Seung Hyeok [Department of Microbiology and Immunology, Institute for Experimental Animals, Seoul National University College of Medicine, Seoul 110-799 (Korea, Republic of); Payumo, Alexander Y.; Chen, James K. [Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305 (United States); Kwon, Ho Jeong, E-mail: kwonhj@yonsei.ac.kr [Chemical Genomics National Research Laboratory, Department of Biotechnology, Translational Research Center for Protein Function Control, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749 (Korea, Republic of)

    2013-04-19

    Highlights: ► This is the first functional characterization of UQCRB in vivo model. ► Angiogenesis is inhibited with UQCRB loss of function in zebrafish. ► UQCRB is introduced as a prognostic marker for mitochondria- and angiogenesis-related diseases. -- Abstract: As a subunit of mitochondrial complex III, UQCRB plays an important role in complex III stability, electron transport, and cellular oxygen sensing. Herein, we report UQCRB function regarding angiogenesis in vivo with the zebrafish (Danio rerio). UQCRB knockdown inhibited angiogenesis in zebrafish leading to the suppression of VEGF expression. Moreover, the UQCRB-targeting small molecule terpestacin also inhibited angiogenesis and VEGF levels in zebrafish, supporting the role of UQCRB in angiogenesis. Collectively, UQCRB loss of function by either genetic and pharmacological means inhibited angiogenesis, indicating that UQCRB plays a key role in this process and can be a prognostic marker of angiogenesis- and mitochondria-related diseases.

  5. THE ROLE AND IMPORTANCE OF “PUBLIC INFORMATION” IN POLITICAL PUBLIC RELATIONS

    Directory of Open Access Journals (Sweden)

    Kazım Özkan ERTÜRK

    2015-04-01

    Full Text Available Public relations is the practice of managing a communication process that aims to build mutual goodwill and trust between organizations and their publics with the help of publicity, information and positive image building efforts. Public information is the public relations approach which aims for providing mutual goodwill and trust by sharing the organization-related information with target audience in complete openness and honesty. Public Information, firstly introduced by Ivy Ledbetter Lee in the United States of America during 1920’s, became prominent as a public relations model which provided an innovative viewpoint on commercial and organizational communication policies. In time, public information practices in public relations began to be utilized for building and maintaining political trust and support of target audience. In this study, application methods of public information activities as a political public relations action and their benefits provided to organization are outlined.

  6. A Disciplinary Perspective: The Internationalization of Australian Public Relations Education

    Science.gov (United States)

    Fitch, Kate

    2013-01-01

    This article investigates the internationalization of public relations education, by examining public relations education in Australia, its relation with the public relations industry, and its growth in response to international student- and market-led demand. The discussion highlights the tensions within what is essentially an education project…

  7. Peritoneal Fluid Reduces Angiogenesis-Related MicroRNA Expression in Cell Cultures of Endometrial and Endometriotic Tissues from Women with Endometriosis

    Science.gov (United States)

    Braza-Boïls, Aitana; Gilabert-Estellés, Juan; Ramón, Luis A.; Gilabert, Juan; Marí-Alexandre, Josep; Chirivella, Melitina; España, Francisco; Estellés, Amparo

    2013-01-01

    Endometriosis, defined as the presence of endometrium outside the uterus, is one of the most frequent gynecological diseases. It has been suggested that modifications of both endometrial and peritoneal factors could be implicated in this disease. Endometriosis is a multifactorial disease in which angiogenesis and proteolysis are dysregulated. MicroRNAs (miRNAs) are small non-coding RNAs that regulate the protein expression and may be the main regulators of angiogenesis. Our hypothesis is that peritoneal fluid from women with endometriosis could modify the expression of several miRNAs that regulate angiogenesis and proteolysis in the endometriosis development. The objective of this study has been to evaluate the influence of endometriotic peritoneal fluid on the expression of six miRNAs related to angiogenesis, as well as several angiogenic and proteolytic factors in endometrial and endometriotic cell cultures from women with endometriosis compared with women without endometriosis. Methods Endometrial and endometriotic cells were cultured and treated with endometriotic and control peritoneal fluid pools. We have studied the expression of six miRNAs (miR-16, -17-5p, -20a, -125a, -221, and -222) by RT-PCR and protein and mRNA levels of vascular endothelial growth factor-A, thrombospondin-1, urokinase plasminogen activator and plasminogen activator inhibitor-1 by ELISA and qRT-PCR respectively. Results Control and endometriotic peritoneal fluid pools induced a significant reduction of all miRNAs levels in endometrial and endometriotic cell cultures. Moreover, both peritoneal fluids induced a significant increase in VEGF-A, uPA and PAI-1 protein levels in all cell cultures without significant increase in mRNA levels. Endometrial cell cultures from patients treated with endometriotic peritoneal fluid showed lower expression of miRNAs and higher expression of VEGF-A protein levels than cultures from controls. In conclusion, this “in vitro” study indicates that

  8. Integrating Public Relations with Advertising: An Exercise for Students in the College Public Relations Campaigns Course

    Science.gov (United States)

    Moody, Reginald Ford

    2012-01-01

    Today's public relations (PR) campaigns courses give students the opportunity to research, analyze, plan, and, in many cases, execute a campaign for a real client. Even so, today's campaigns courses may leave students with a weak understanding of how PR can best partner with other tools in the communication mix, namely advertising. Educators may…

  9. Urokinase plasminogen activator and plasminogen activator inhibitor type-1 in nonsmall-cell lung cancer: relation to prognosis and angiogenesis

    DEFF Research Database (Denmark)

    Offersen, Birgitte Vrou; Pfeiffer, Per; Andreasen, Peter

    2007-01-01

    years. CONCLUSIONS: The present study investigated the prognostic role of the protein levels of uPA and PAI-1 in 118 tumour specimens from patients diagnosed with NSCLC. Neither of the factors were identified as prognostic markers when evaluated with survival as endpoint. However, in tumours previously...... to angiogenesis. MATERIALS AND METHODS: Frozen tumour tissue from surgical specimens from 118 previously untreated patients diagnosed with NSCLC in the period 1984-1991 were investigated. All patients were treated with surgery, and no chemo- or radiotherapy was given. UPA and PAI-1 levels were assessed using...... a sandwich ELISA method. RESULTS: Both uPA and PAI-1 were independent of classical histopathological parameters as well as of microvessel density and vascular pattern. Using death within the first 5 years as endpoint, neither of the factors were prognostic markers in univariate analysis, however...

  10. Introduction to the Paradigm Struggle in Public Relations.

    Science.gov (United States)

    Botan, Carl

    1993-01-01

    Describes the ongoing state of change in the domain of public relations, with special attention to model shifts. Defines model struggles and discusses the emergence of international public relations along with other recent trends. (HB)

  11. Public Relations a komunikace ve zdravotnictví

    OpenAIRE

    Polanecká, Šárka

    2009-01-01

    The goal of theses is to introduce the theoretical knowledge in the field of Public Relations and subsequently on the basis of marketing research to map the situation of public relations management between hospitals in the Czech Republic.

  12. Effect of angiopoietin-related protein 2 on coronary angiogenesis and myocardial function in a porcine model of acute myocardial ischemia

    Institute of Scientific and Technical Information of China (English)

    Shu Meng; Changqian Wang; Fei Wang; Renjian Zhou; Fangbao Ding; Fuxin Chen

    2008-01-01

    Our previous studies have suggested that angiopoietin-related protein 2 (Arp2) may improve rat cardiac function after acute myocardial infarction (AMI) by accelerating angiogenesis.We want to study the efficacy of the adenoviral vector-mediated gene transfer of Arp2 (Ad.Arp2) in inducing angiogenesis and in improving the myocardial perfusion and function in a porcine acute myocardial ischemic model.Methods The minipigs underwent ligation of the proximal circumflex coronary artery (LCx) and were randomly assigned to treatment with Ad.Arp2,adenoviral vectors with no transgene (Ad.Null) or PBS.Four weeks later,the animals were evaluated using echocardiography,cardiac perfusion imaging and pathologic observation.Results Four weeks after treatment,the Arp2 protein was revealed in the myocardium of Ad.Arp2 animals,but was not found in the Ad.Null or PBS animals.Also,a significant revival of myocardial perfusion was found in the ischemic area in Ad.Arp2-treated animals,whose global and regional myocardial function was greatly improved.The quantitation of new capillaries was much greater in the Ad.Arp2 group than in the Ad.Null or PBS groups.Conclusion Treatment with Ad.ARP2 offers the obvious advantage of greatly improving the blood supply and the heart function.(J Geriatr Cardiol 2008;5:230-234)

  13. Challenging Assumptions of International Public Relations: When Government Is the Most Important Public.

    Science.gov (United States)

    Taylor, Maureen; Kent, Michael L.

    1999-01-01

    Explores assumptions underlying Malaysia's and the United States' public-relations practice. Finds many assumptions guiding Western theories and practices are not applicable to other countries. Examines the assumption that the practice of public relations targets a variety of key organizational publics. Advances international public-relations…

  14. Teaching the Introductory Public Relations Course: A Communication Perspective.

    Science.gov (United States)

    Measell, James S.

    Expressing a communication perspective on teaching public relations, this booklet is designed for instructors of public relations courses. The introduction to the booklet establishes the theoretical grounding of this investigation, namely, the mutual relationship between public relations and communication. The first section explicates the…

  15. On the definition of public relations: a European view

    NARCIS (Netherlands)

    van Ruler, A.A.; Vercic, D.; Buetschi, G.; Flodin, B.

    2001-01-01

    The article confronts a U.S.-based definition of public relations as relationship management with a European view that besides a relational, argues also for a reflective paradigm that is concerned with publics and the public sphere; not only with relational (which can in principle be private), but a

  16. Reactions to the New Standards for School Public Relations Specialists.

    Science.gov (United States)

    Kowalski, Theodore J.

    2002-01-01

    Reactions by 10 individuals associated with the "Journal of School Public Relations" to new National School Public Relations Association standards for school public relations and communications professionals and programs. Includes general reactions, impact of the standards, possible ambiguity, adding or eliminating standards, and influence on…

  17. Selling the Internet: A Cultural Studies Approach to Public Relations.

    Science.gov (United States)

    Mickey, Thomas J.

    1998-01-01

    Examines the ideology of Internet public relations. Takes a cultural studies approach to modern public relations, using public relations material as representation. Presents a case study of the MassNetworks Education Partnership, which was set up in 1996 to ensure that the Internet gets into the classroom. (PA)

  18. Intercultural Interpretations: Making Public Relations Education Culturally Relevant

    Science.gov (United States)

    Chia, Joy

    2009-01-01

    Public relations educators delivering courses to international students find that each cohort of students interprets and understands public relations theory and its application to practice according to their respective cultures. The premise of this paper is to reflect on some of the interpretations and expectations of public relations students…

  19. Reactions to the New Standards for School Public Relations Specialists.

    Science.gov (United States)

    Kowalski, Theodore J.

    2002-01-01

    Reactions by 10 individuals associated with the "Journal of School Public Relations" to new National School Public Relations Association standards for school public relations and communications professionals and programs. Includes general reactions, impact of the standards, possible ambiguity, adding or eliminating standards, and…

  20. Vaccinations: A public health triumph and a public relations tragedy.

    Science.gov (United States)

    Jacobson, Robert M

    2012-08-01

    Routine vaccination has been hailed as one of the top public health achievements of the last century. However, despite the reduced number of cases of and deaths from vaccine-preventable diseases such as pertussis and measles, outbreaks continue to occur as more parents fail to adequately vaccinate their children because of misinformation about immunizations. This article describes the challenges of making sure all children in the United States are fully immunized and what physicians need to know to effectively work with parents who may be hesitant to vaccinate their children.

  1. DIFFERENT SIDES OF THE SAME COIN: MIXED VIEWS OF PUBLIC RELATIONS EDUCATORS AND PRACTITIONER ABOUT PUBLIC RELATIONS EDUCATION

    OpenAIRE

    BİR, Çisil Sohodol

    2010-01-01

    Public relations education is a topic of seemingly perpetual importance and interest for practitioners and educators alike In recent years, numerous researches have surveyed both practitioners and educators to identify appropriate ways to strengthen public relations education to prepare students for practitioner’s role. According to these research results public relations educators and practitioners disagree about the priorities they assign to qualities and goals of public relations education...

  2. Using public relations to promote health: a framing analysis of public relations strategies among health associations.

    Science.gov (United States)

    Park, Hyojung; Reber, Bryan H

    2010-01-01

    This study explored health organizations' public relations efforts to frame health issues through their press releases. Content analysis of 316 press releases from three health organizations-the American Heart Association, the American Cancer Society, and the American Diabetes Association-revealed that they used the medical research frame most frequently and emphasized societal responsibility for health issues. There were differences, however, among the organizations regarding the main frames and health issues: the American Diabetes Association was more likely to focus on the issues related to social support and education, while the American Heart Association and the American Cancer Society were more likely to address medical research and scientific news. To demonstrate their initiatives for public health, all the organizations employed the social support/educational frame most frequently. Researchers and medical doctors frequently were quoted as trusted sources in the releases.

  3. Current Developments in Public Relations and a Review of their Implications on Public Relations Curriculum in Canada.

    Science.gov (United States)

    Wills, Sandra Judith Abiola

    Intended to review the recent professional developments in public relations as they are documented in the literature and to explore the implications of these developments for public relations education in Canada at the university level, this thesis is in six chapters, as follows: (1) Introduction; (2) Defining Public Relations; (3) Current Public…

  4. Mediators of ocular angiogenesis

    Indian Academy of Sciences (India)

    Yureeda Qazi; Surekha Maddula; Balamurali K. Ambati

    2009-12-01

    Angiogenesis is the formation of new blood vessels from pre-existing vasculature. Pathologic angiogenesis in the eye can lead to severe visual impairment. In our review, we discuss the roles of both pro-angiogenic and anti-angiogenic molecular players in corneal angiogenesis, proliferative diabetic retinopathy, exudative macular degeneration and retinopathy of prematurity, highlighting novel targets that have emerged over the past decade.

  5. PR for Pennies: Low-Cost Library Public Relations.

    Science.gov (United States)

    Baeckler, Virginia Van Wynen

    This manual is designed to demystify a number of public relations techniques for those who wish to start producing their own materials with a minimum of time and money. Chapters focus on public relations; the library stereotype; words, ideas, and pictures; offset printing; creative print distribution; exhibits and posters; public speaking; and the…

  6. The role of public relations activities in hospital choice.

    Science.gov (United States)

    Tengilimoglu, Dilaver; Yesiltas, Mehmet; Kisa, Adnan; Dziegielewski, Sophia F

    2007-01-01

    Public relations activities for all organizations can have an important effect on consumer decision-making when buying goods or services. This study examines the effect that public relations activities can have regarding consumer decisions and choice. To explore exemplify this relationship a questionnaire was given to 971 patients within public, university and private hospitals in Ankara, Turkey. Study results show that public relations activities were a crucial factor in determining consumer hospital choice. The majority of respondents reported that the behaviors and attitude of personnel as public relations activities that support the hospital's reputation within the public were the primary variables in hospital choice. Health care managers can use these findings to further understand how patients make informed choices related to usage of a health care facility and to develop and/or improve public relations activities.

  7. Inducible nitric oxide synthase expression is related to angiogenesis, bcl-2 and cell proliferation in hepatocellular carcinoma

    Institute of Scientific and Technical Information of China (English)

    彭佳萍; 郑树; 孝作祥; 张苏展

    2003-01-01

    In this study, we examined the expression of inducible nitric oxide synthase (iNOS) and vascular endothelial growth factor (VEGF) by immunohistochemical staining in 76 tissue sections collected from hepatocellular carcinoma (HCC) patients undergoing hepatectomy. Microvascular density (MVD) was determined by counting endothelial cells immunostained using anti-CD34 antibody. We performed DNA-flow cytometric analyses to elucidate the impact of iNOS and VEGF expression on the cell cycle of HCC. Most of the HCC cells that invaded stroma were markedly immunostained by iNOS antibody. The iNOS stain intensity of the liver tissue close to the tumor edge was stronger than that of HCC tissue, and the strongest was the hepatocytes closer to the tumor tissue. However, iNOS expression in 10 normal hepatic samples was undetectable. VEGF positive expression ratio was 84.8% in iNOS positive expression cases, and the ratio was 35.3% in negative cases. There was significant correlation (P=0.000) between iNOS and VEGF expression. Moreover, iNOS expression was significantly associated with bcl-2 and MVD, but without p53 expression. DNA-flow cytometric analyses showed that combined expression of iNOS and VEGF had significant impact on the cell cycle in HCC. PI (Proliferating Index) and SPF (S-phase fraction) in the combined positive expression of iNOS and VEGF group was significantly higher than that in the combined negative group. The present findings suggested that iNOS expression was significantly associated with angiogenesis, bcl-2 and cell proliferation of HCC.

  8. Public Congestion Network Situations, and Related Games

    NARCIS (Netherlands)

    Kleppe, J.; Reijnierse, J.H.

    2007-01-01

    This paper analyzes congestion effects on network situations from a cooperative game theoretic perspective. In network situations players have to connect themselves to a source. Since we consider publicly available networks any group of players is allowed to use the entire network to establish their

  9. Soliton driven angiogenesis

    Science.gov (United States)

    Bonilla, L. L.; Carretero, M.; Terragni, F.; Birnir, B.

    2016-08-01

    Angiogenesis is a multiscale process by which blood vessels grow from existing ones and carry oxygen to distant organs. Angiogenesis is essential for normal organ growth and wounded tissue repair but it may also be induced by tumours to amplify their own growth. Mathematical and computational models contribute to understanding angiogenesis and developing anti-angiogenic drugs, but most work only involves numerical simulations and analysis has lagged. A recent stochastic model of tumour-induced angiogenesis including blood vessel branching, elongation, and anastomosis captures some of its intrinsic multiscale structures, yet allows one to extract a deterministic integropartial differential description of the vessel tip density. Here we find that the latter advances chemotactically towards the tumour driven by a soliton (similar to the famous Korteweg-de Vries soliton) whose shape and velocity change slowly. Analysing these collective coordinates paves the way for controlling angiogenesis through the soliton, the engine that drives this process.

  10. PERKEMBANGAN TEKNOLOGI KOMUNIKASI DALAM MENUNJANG FUNGSI PERIKLANAN DAN PUBLIC RELATION

    Directory of Open Access Journals (Sweden)

    Nurul Candrasari

    2010-03-01

    Full Text Available Society has been flooded by advertised communication atmosphere for every product to be socialized and introduced to the public. However, there are problems arising from the consumer when the product being advertised is felt only one-sided communication, because in an advertised product consumers often encounter some problems in which they cannot consider them to be their choice. That is why at the present time the world of advertising does not seem to be a choice in marketing a product to consumers. Article presents the relationship among advertisement, public relation, and communication technology in five parts, those are age sequences from agriculture to conceptual era and its relation to advertisement and public relation, developing advertisement network and public relation using new technology, difference between advertisement and public relation, and communication technology ethic supporting advertisement and public relation.

  11. High Touch: PR. Practical Approaches to Public Relations.

    Science.gov (United States)

    Keefe, Betty; And Others

    1986-01-01

    This article relates tried, tested, and successful public relations programs in use at school library media centers. A four-step process for developing a suitable public relations program (research, planning, action, and evaluation) and programs that focus on communicating with school staff, administrators, parents, and the community are…

  12. Social Media, Traditional Media and Marketing Communication of Public Relations

    DEFF Research Database (Denmark)

    Khajeheian, Datis; Mirahmadi, Fereshteh

    2015-01-01

    Public relations are undertaking more important role in the marketing communication and advertising. The present paper reports a survey conducted in three Iranian banks’ public relations departments to understand how they use different media in their marketing communications and other related...

  13. Public Relations as Scientific Branch of Information and Communication Sciences

    Directory of Open Access Journals (Sweden)

    Hrvoje Jakopović

    2012-06-01

    Full Text Available Given that the field of information and communication sciences is a young field in the social sciences, it is important to consider how technology impacts the development of this field. This is especially relevant when looking at the area of public relations. Amid changing technological developments public relations is constantly being redefined in this complex environment. This work focuses on the development of public relations as a branch of study in the field of information and communication sciences. I review the scientific methods used to evaluate the influence and effects of public relations, while discussing the different methodological approaches.

  14. Ethics of the profession of public relations--does the public relations affects on journalism in Croatia?

    Science.gov (United States)

    Tanta, Ivan; Lesinger, Gordana

    2013-09-01

    The UK's leading professional body for public relations "Chartered Institute of Public Relations" (CIPR) said that the public relations is about reputation--they are the result of what you do, what you say and what others say about you. Furthermore CIPR says that public relations are discipline whose objectives are safeguarding reputation, establishing understanding and pot pores, and the impact on the thinking and behavior of the public. Although the primary goal of public relations is to preserve and build a reputation, to tell the truth to a customer who has hired experts in this area, it seems that in its own way of development, public relations practitioners have stopped worrying about their reputation and the perception of the discipline within the public they address. All relevant professional bodies for public relations, including the Croatian Association for Public Relation (HUOJ), had set up codes of ethics and high standards according which the members and practitioners should be evaluated. Among other things stays that practitioner of public relations is required to check the reliability and accuracy of the data prior to their distribution and nurture honesty and accountability to the public interest. It seems that right this instruction of code of ethics has been often violated. In a public speech in Croatia, and therefore in the media, exist manipulation, propaganda, and all the techniques of spin, which practitioners of public relations are skillfully using in the daily transfer of information to the users and target groups. The aim of this paper is to determine what is the perception of the profession to the public. As in today's journalism increasingly present plume of public relations, we wish to comment on the part where journalism ends and begins PR and vice versa. In this paper, we analyze and compare codes of ethics ethics associations for public relations, as well as codes of ethics journalists' associations, in order to answer the question

  15. Approaches to organizing public relations functions in healthcare.

    Science.gov (United States)

    Guy, Bonnie; Williams, David R; Aldridge, Alicia; Roggenkamp, Susan D

    2007-01-01

    This article provides health care audiences with a framework for understanding different perspectives of the role and functions of public relations in healthcare organizations and the resultant alternatives for organizing and enacting public relations functions. Using an example of a current issue receiving much attention in US healthcare (improving rates of organ donation), the article provides examples of how these different perspectives influence public relations goals and objectives, definitions of 'public', activities undertaken, who undertakes them and where they fit into the organizational hierarchy.

  16. Monocyte Subpopulations in Angiogenesis

    Science.gov (United States)

    Dalton, Heather J.; Armaiz-Pena, Guillermo; Gonzalez-Villasana, Vianey; Lopez-Berestein, Gabriel; Bar-Eli, Menashe; Sood, Anil K.

    2014-01-01

    Growing understanding of the role of the tumor microenvironment in angiogenesis has brought monocyte-derived cells into focus. Monocyte subpopulations are an increasingly attractive therapeutic target in many pathologic states, including cancer. Before monocyte-directed therapies can be fully harnessed for clinical use, understanding of monocyte-driven angiogenesis in tissue development and homeostasis, as well as malignancy, is required. Here, we provide an overview of the mechanisms by which monocytic subpopulations contribute to angiogenesis in tissue and tumor development, highlight gaps in our existing knowledge, and discuss opportunities to exploit these cells for clinical benefit. PMID:24556724

  17. Public Relations Bibliography: Thirteenth Edition 1984.

    Science.gov (United States)

    Walker, Albert

    1985-01-01

    Includes titles from more than 180 periodicals published in 1984, with most of the literature continuing to center on communication, media relations, and writing techniques. Also includes books, theses, and dissertations. (PD)

  18. Promoting Vocational Education. A Public Relations Handbook for Vocational Educators.

    Science.gov (United States)

    American Vocational Association, Arlington, VA.

    This handbook for vocational educators was developed as a tool to help them in their public relations efforts. Following a brief introduction, the content is presented in twelve sections. The first discusses the roles of various professionals and groups in vocational education. Section 2 covers planning a total public relations program and…

  19. Marketing and Public Relations in ARL Libraries. SPEC Kit 240.

    Science.gov (United States)

    Smykla, Evelyn Ortiz, Comp.

    1999-01-01

    This survey was conducted to delineate the growing relationship between marketing and public relations and library funding by identifying: (1) the extent to which North American research libraries have developed organized programs in the areas of marketing and public relations; (2) who holds positions in these areas; and (3) the impact these…

  20. A public relations identity for the 2010s

    NARCIS (Netherlands)

    Ihlen, Ø.; Verhoeven, P.

    2012-01-01

    New voices are being heard and new questions are being asked within the field of public relations. However, in its present multifaceted state, public relations research is still struggling with recurring questions regarding academic and practical contributions. This position article presents some co

  1. Enforcement Dilemma: Voluntary Nature of Public Relations Codes.

    Science.gov (United States)

    Wright, Donald K.

    1993-01-01

    Argues that, although valuable, ethical codes in public relations are unenforceable. Suggests that, with or without professional codes of conduct, most people who practice public relations will choose to be ethical because they believe in themselves and want others to respect them. (SR)

  2. Moral Objectivity, Jurgen Habermas's Discourse Ethics, and Public Relations.

    Science.gov (United States)

    Leeper, Roy V.

    1996-01-01

    States that while increasing attention is being paid by people in public relations to ethical theory, the predominant ethical perspective is still situational. Analyzes the applicability of the Discourse Ethics theory of Jurgen Habermas to public relations ethics. Concludes that Discourse Ethics holds the potential of a new, more objective…

  3. The Impact of IMC on Advertising and Public Relations Education.

    Science.gov (United States)

    Griffin, W. Glenn; Pasadeos, Yorgo

    1998-01-01

    Surveys advertising and public relations faculty members with regard to IMC (Integrated Marketing Communications) and its impact on current curricula. Finds (1) areas of discontent with current course curricula; (2) evidence of "separate agendas" between advertising and public relations educators on this issue; and (3) evidence of a generation gap…

  4. Developing a Behavioral Paradigm for the Performance of Public Relations.

    Science.gov (United States)

    Sharpe, Melvin L.

    2000-01-01

    Provides and supports a definition of public relations as behavior with a mode explaining the difficulty of achieving each behavior and the cost to organizations when the behavior is not achieved. Draws from the literature on ethics, rhetorical theory, public relations management, case studies, and from observation and experience to support this…

  5. Crisis Communication Plans: Poor Predictors of Excellent Crisis Public Relations.

    Science.gov (United States)

    Marra, Francis J.

    1998-01-01

    Argues that newly developed theory in crisis public relations suggests a shift is necessary in the way practitioners view crises. Notes that the new paradigm defines excellent crisis public relations very differently from the literature of the past 20 years. (RS)

  6. A Context for Teaching Aging-Related Public Policy.

    Science.gov (United States)

    Brown, David K.

    1999-01-01

    Describes two points of view regarding age-related public programs (Medicaid, Medicare, Social Security): that of devolutionists who would curtail them and safety netters who maintain the government's role is indispensable. Uses Relative Deprivation theory as a framework for teaching public policy about aging. (SK)

  7. Emotional Intelligence and Its Link to Public Relations Education

    Science.gov (United States)

    Howard, Timothy Lent

    2011-01-01

    The purpose of this study is to examine the ethics chapters in five introduction-to-public relations textbooks and the codes of ethics of four major public relations associations contained within those chapters to determine the prevalence of language that either uses the same terms Daniel Goleman employs for his 25 competencies of emotional…

  8. The Global Society and Its Impact on Public Relations Theorizing

    DEFF Research Database (Denmark)

    Valentini, Chiara; Kruckeberg, Dean; Starck, Kenneth

    2016-01-01

    This article contributes to the discussion on societal changes and their impact on communication disciplines by focusing on public relations and its role in contemporary global society. The thesis is that public relations profession has been affected by contemporary societal changes that challenge...... the existing body of knowledge and its underpinning theories. To understand the role of public relations in the 21st Century global societies and pursue future public relations theorizing, the authors argue it is paramount to comprehend which factors at macro, meso, and micro levels lie beneath the substantial...... changes in today’s global society. The article presents and reflects on four major macro trends of contemporary global society and concludes with suggestions for future directions for public relations scholarship and practice that are rooted in the concept of community and the idea of being part...

  9. Personalised Networks of Influence in Public Relations

    DEFF Research Database (Denmark)

    Valentini, Chiara

    2010-01-01

    of influence are also tested with Italian journalists to verify whether or not other communication-related professions consider important to have personalised networks of influence and whether or not this relevance is perceived similar to that of PR practitioners. The data of this study was gleaned from...

  10. Measuring Corporate Social Responsibility Perceptions in Public Relation

    Directory of Open Access Journals (Sweden)

    Ayse Banu Bicakci

    2011-04-01

    Full Text Available This paper focuses on the relationship between Corporate Social Responsibility and Public Relations. Public Relations plays a significant role in the process of developing the concept of corporate social responsibility (CSR, the fulfillment of those responsibilities, providing the effective communication and also it serves as a bridge connecting the organisation and the publics. To manage CSR policy and communication effectively, public perception of organisations’ social responsibility should be measured. Based on this idea employee perception of their organization’s social responsibility is measured, benefiting from four factors.

  11. The Double-Edged Sword of Legitimacy in Public Relations

    DEFF Research Database (Denmark)

    Merkelsen, Henrik

    2011-01-01

    Purpose – This paper seeks to clarify the various aspects of legitimacy in public relations in order to establish a better understanding of the limits of professionalization. Legitimacy has always been a central concept in public relations. In order to ensure a license to operate, the conduct...... of organizations needs to be perceived as legitimate by their stakeholders and the public in general. Public relations has since its conception as a modern profession been confronted with several issues concerning the profession's own legitimacy. The overall cause for these legitimacy problems is often ascribed...... to the immaturity of the profession and professionalization is generally regarded as an appropriate cure. Design/methodology/approach – Through theorization of the connection between legitimacy, power and professionalization the paper points to two important challenges to the professionalization of public relations...

  12. The evolution of public relations measurement and evaluation

    OpenAIRE

    Watson, Tom

    2012-01-01

    The measurement and evaluation of public relations effectiveness has long been a major professional and research issue. In the first half of the 20th century, there were two research methods applied, opinion polls and basic media analysis. These were used to plan campaigns and monitor progress of media relations activities. In the second half of the century, as the practices of public relations expanded, greater emphasis was given to media analysis but the evidence of many practitioner studie...

  13. Public Health Ethics Related Training for Public Health Workforce: An Emerging Need in the United States

    Directory of Open Access Journals (Sweden)

    A Kanekar

    2012-04-01

    Full Text Available Background: Ethics is a discipline, which primarily deals with what is moral and immoral behavior. Public Health Ethics is translation of ethical theories and concepts into practice to address complex multidimensional public health problems. The primary purpose of this paper was to conduct a narrative literature review-addressing role of ethics in developing curriculum in programs and schools of public health, ethics-related instruction in schools and programs of public health and the role of ethics in developing a competent public health workforce. Methods: An open search of various health databases including Google scholar and Ebscohost yielded 15 articles related to use of ethics in public health practice or public health training and the salient features were reported.  Results: Results indicated a variable amount of ethics' related training in schools and programs of public health along with public health practitioner training across the nation. Bioethics, medical ethics and public health ethics were found to be subspecialties' needing separate ethical frameworks to guide decision making.Conclusions: Ethics based curricular and non-curricular training for emerging public health professionals from schools and programs of public health in the United States is extremely essential.  In the current age of public health challenges faced in the United States and globally, to have an ethically untrained public health force is arguably, immoral and unethical and jeopardizes population health.  There is an urgent need to develop innovative ethic based curriculums in academia as well as finding effective means to translate these curricular competencies into public health practice.

  14. A targeted inhibitor of the complement alternative pathway reduces RPE injury and angiogenesis in models of age-related macular degeneration.

    Science.gov (United States)

    Rohrer, Bärbel; Long, Qin; Coughlin, Beth; Renner, Brandon; Huang, Yuxiang; Kunchithapautham, Kannan; Ferreira, Viviana P; Pangburn, Michael K; Gilkeson, Gary S; Thurman, Joshua M; Tomlinson, Stephen; Holers, V Michael

    2010-01-01

    Genetic variations in complement factor H (fH), an inhibitor of the complement alternative pathway (CAP), and oxidative stress are associated with age-related macular degeneration (AMD). Recently, novel complement therapeutics have been created with the capacity to be "targeted" to sites of complement activation. One example is our recombinant form of fH, CR2-fH, which consists of the N-terminus of mouse fH that contains the CAP-inhibitory domain, linked to a complement receptor 2 (CR2) targeting fragment that binds complement activation products. CR2-fH was investigated in vivo in the mouse model of choroidal neovascularization (CNV) and in vitro in oxidatively stressed RPE cell monolayers. RPE deterioration and CNV development were found to require CAP activation, and specific CAP inhibition by CR2-fH reduced the loss of RPE integrity and angiogenesis in CNV. In both the in vivo and in vitro paradigm of RPE damage, a model requiring molecular events known to be involved in AMD, complement-dependent VEGF production, was confirmed. These data may open new avenues for AMD treatment strategies.

  15. 40 CFR 300.155 - Public information and community relations.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 27 2010-07-01 2010-07-01 false Public information and community...) SUPERFUND, EMERGENCY PLANNING, AND COMMUNITY RIGHT-TO-KNOW PROGRAMS NATIONAL OIL AND HAZARDOUS SUBSTANCES... community relations. (a) When an incident occurs, it is imperative to give the public prompt,...

  16. Teaching the Public Relations Case Studies/Campaigns Class.

    Science.gov (United States)

    Cottone, Laura Perkins

    The public relations case studies/campaigns class entails teaching students how to die and then come back to life. As students must learn to take a critical look at complex public and social issues, teachers should create an environment in which the students feel comfortable with the process of psychological reconstruction. Students must be taught…

  17. GENDER BIAS IN THE PUBLIC RELATIONS INDUSTRY IN MALAYSIA: COMPARING PUBLIC RELATIONS PRACTITIONERS’ JOB FUNCTIONS, INCOMES, AND CAREER PROSPECTS

    Directory of Open Access Journals (Sweden)

    Yesuselvi Manickam

    2016-12-01

    Full Text Available Today, there is an increase in women working outside their home to sustain themselves economically and socially, but the working experiences can be problematic for women when gender discrimination exists in the workplace. In the early 1960s, women were entering the public relations industry at a rate faster than their male counterparts, but gender bias was a sore issue in the industry. Numerous studies have been conducted on gender bias, and the findings indicate that female public relations practitioners receive unequal treatment in their organisation. For that reason, this study investigated whether gender bias exists in the public relations industry in Klang Valley, Malaysia, and if so, what the impact was on the practitioners’ work performance. The study used an in-depth interview with five public relations practitioners from public relations agencies and corporate companies. Feminist Standpoint Theory served as a framework for this study. Results revealed that in Malaysia, gender bias is not prevalent because of cultural diversity and company policies. The priorities of these public relations agencies and organisations favor employee’s performance and competence over gender. The results also indicated that public relations practitioners are treated fairly in areas of career prospects, job functions, and remuneration.

  18. Public Relations and An Argument about Problems of New Media

    Directory of Open Access Journals (Sweden)

    Ebru Ozgen

    2011-03-01

    Full Text Available The study explores the advantages and disadvantages new media, i.e. the Internet, has brought to the Public Relations discipline and in doing so emphasizes that it is vital to consider these positive and negative effects.

  19. Transmedia marketing and re-invention of public relations

    Directory of Open Access Journals (Sweden)

    Jakus Dalibor

    2016-12-01

    Full Text Available Many concepts have been developed to describe the convergence of media, public relations and storytelling formats in contemporary media systems. This article presents a theoretical reflection on “transmedia storytelling” from a perspective of integration narrative in the context of the re-invention of public relations. The rapid evolution of digital media technology and the emergence of transmedia storytelling present foresight professionals with a powerful new approach for communicating about the future. A transmedia story unfolds across multiple media platforms with each new text making a distinctive and valuable contribution to the whole. Between other, this article also outlines some of the key principles and elements of transmedia storytelling in combination with modern public relations, in order to provide a basic framework that public relations practitioner can use when designing transmedia projects.

  20. Selecting public relations personnel of hospitals by analytic network process.

    Science.gov (United States)

    Liao, Sen-Kuei; Chang, Kuei-Lun

    2009-01-01

    This study describes the use of analytic network process (ANP) in the Taiwanese hospital public relations personnel selection process. Starting with interviewing 48 practitioners and executives in north Taiwan, we collected selection criteria. Then, we retained the 12 critical criteria that were mentioned above 40 times by theses respondents, including: interpersonal skill, experience, negotiation, language, ability to follow orders, cognitive ability, adaptation to environment, adaptation to company, emotion, loyalty, attitude, and Response. Finally, we discussed with the 20 executives to take these important criteria into three perspectives to structure the hierarchy for hospital public relations personnel selection. After discussing with practitioners and executives, we find that selecting criteria are interrelated. The ANP, which incorporates interdependence relationships, is a new approach for multi-criteria decision-making. Thus, we apply ANP to select the most optimal public relations personnel of hospitals. An empirical study of public relations personnel selection problems in Taiwan hospitals is conducted to illustrate how the selection procedure works.

  1. Transmedia marketing and re-invention of public relations

    OpenAIRE

    Jakus Dalibor; Zubčić Krešimir

    2016-01-01

    Many concepts have been developed to describe the convergence of media, public relations and storytelling formats in contemporary media systems. This article presents a theoretical reflection on “transmedia storytelling” from a perspective of integration narrative in the context of the re-invention of public relations. The rapid evolution of digital media technology and the emergence of transmedia storytelling present foresight professionals with a powerful new approach for communicating abou...

  2. Evidence on the relation between public capital and government efficiency

    OpenAIRE

    Guedes de Oliveira, Francisca

    2010-01-01

    This paper intends to contribute to the literature by providing empirical evidence on the relation between public capital stock and government efficiency. We present some objective indicators fo government efficiency and explore the mentioned relation. we find a positive and significant relation between both variables that survives the introduction of controls and robustness checking.

  3. PERCEPTIONS ON THE RELATIONSHIP BETWEEN PUBLIC RELATIONS PRACTITIONERS AND JOURNALISTS

    Directory of Open Access Journals (Sweden)

    Halimahton Shaari

    2006-01-01

    Full Text Available This research examines perceptions on the relationship between public relations practitioners and journalists based on four categories of relationship: Satisfaction with contributions made to each other, interdependence, trust and ethical practices. A survey of 48 public relations practitioners and 63 journalists was conducted regarding their perceptions on each other’s profession. Public relations practitioners polled for this survey were from the various government and corporate organisations while the journalists were from the print and electronic media organisations and publishing houses. Generally, the survey indicates some differences and similarities in the perceptions of the two groups with public relations practitioners holding stronger perceptions than the journalists on the various aspects of their relationship. The data suggests that public relations practitioners believe more strongly that the information they provide to the journalists enables the latter to perform more satisfactorily compared to the journalists who think less strongly of the contribution made by the former. The public relations practitioners also seem to think that there is more of a symbiotic relationship between the two groups than the journalists.

  4. A STUDY OF SYMBOLIC RELATIONS IN PUBLIC TRANSPORT

    Directory of Open Access Journals (Sweden)

    ANDREI BALAN

    2011-04-01

    Full Text Available This paper presents an anthropological, exploratory study of the microsocial world of public transport. Our research focuses on the symbolic relations that are being established (verbally or nonverbally between urban transport travellers that do not know each other and the consequences these relations create. Modern urban configuration forces large numbers of individuals to share public space every day. When this space becomes restrictive, symbolic relations and interpersonal behaviors such as territoriality and personal space management become clearer. Due to overcrowding, public transport is the scene of one of the most restrictive public spaces in a city. The challenge was to observe and interpret daily, casual behaviors through a sociological and psychological scheme, following the methodological tradition established by Erving Goffman and the other symbolic interactionists. Finally, our study generates a number of hypotheses and explanatory models for common practices and behaviors in trams and metros regarded from a symbolic perspective.

  5. A STUDY OF SYMBOLIC RELATIONS IN PUBLIC TRANSPORT

    Directory of Open Access Journals (Sweden)

    Andrei B LAN

    2011-08-01

    Full Text Available This paper presents an anthropological, exploratory study of the microsocial world of public transport. Our research focuses on the symbolic relations that are being established (verbally or nonverbally between urban transport travellers that do not know each other and the consequences these relations create. Modern urban configuration forces large numbers of individuals to share public space every day. When this space becomes restrictive, symbolic relations and interpersonal behaviors such as territoriality and personal space management become clearer. Due to overcrowding, public transport is the scene of one of the most restrictive public spaces in a city. The challenge was to observe and interpret daily, casual behaviors through a sociological and psychological scheme, following the methodological tradition established by Erving Goffman and the other symbolic interactionists. Finally, our study generates a number of hypotheses and explanatory models for common practices and behaviors in trams and metros regarded from a symbolic perspective.

  6. Gene Therapy with Endogenous Inhibitors of Angiogenesis for Neovascular Age-Related Macular Degeneration: Beyond Anti-VEGF Therapy

    Directory of Open Access Journals (Sweden)

    Selwyn M. Prea

    2015-01-01

    Full Text Available Age-related macular degeneration (AMD is the leading cause of substantial and irreversible vision loss amongst elderly populations in industrialized countries. The advanced neovascular (or “wet” form of the disease is responsible for severe and aggressive loss of central vision. Current treatments aim to seal off leaky blood vessels via laser therapy or to suppress vessel leakage and neovascular growth through intraocular injections of antibodies that target vascular endothelial growth factor (VEGF. However, the long-term success of anti-VEGF therapy can be hampered by limitations such as low or variable efficacy, high frequency of administration (usually monthly, potentially serious side effects, and, most importantly, loss of efficacy with prolonged treatment. Gene transfer of endogenous antiangiogenic proteins is an alternative approach that has the potential to provide long-term suppression of neovascularization and/or excessive vascular leakage in the eye. Preclinical studies of gene transfer in a large animal model have provided impressive preliminary results with a number of transgenes. In addition, a clinical trial in patients suffering from advanced neovascular AMD has provided proof-of-concept for successful gene transfer. In this mini review, we summarize current theories pertaining to the application of gene therapy for neovascular AMD and the potential benefits when used in conjunction with endogenous antiangiogenic proteins.

  7. Effect of Curcumin on Angiogenesis in Aortic Ring Model of the Wistar Rat

    Directory of Open Access Journals (Sweden)

    J Baharara

    2014-08-01

    Conclusion: The results proposed that the Curcumin had dose-dependent inhibitory effects on angiogenesis in rat aortic ring Therefore, it can be introduced as an appropriate candidate in order to study angiogenesis and related diseases.

  8. Institutions of Civil Society Participating in Public Relations

    Directory of Open Access Journals (Sweden)

    Olga S. Belokrylova

    2016-12-01

    Full Text Available The degree of maturity of the civil society of a country is now seen as an important indicator of the development of a socially oriented market economy. The authors explore two forms of state and civil society relations - qualitative, characterized by the diffusion of a relationship of trust in society, and quantitative, in the system of public procurement corruption identifiable pace of localization. Institutional capacity development of civil society in public relations is the simultaneous modernization of the qualitative and quantitative scope of its relationship with the state. The paper presents the mechanism of transition to a partnership model relations between the state and civil society, the most important form of which is the realization of public control, rapid formal institutionalization which has provided detection and elimination of large-scale irregularities in public procurement. Its swift formal institutionalization provided by representatives of civil society to identify and eliminate large-scale irregularities in public procurement. The experience of NGO Fund "Sodeistvie - XXI vek" to identify "blind" purchases, is offered as a tool to improve the efficiency of public control conduct free training of potential public controlles by institutions engaged in training of civil officials for the course "Management of state and municipal procurement".

  9. ER Stress and Angiogenesis.

    Science.gov (United States)

    Binet, François; Sapieha, Przemyslaw

    2015-10-01

    Proper tissue vascularization is vital for cellular function as it delivers oxygen, nutrients, hormones, and immune cells and helps to clear cellular debris and metabolic waste products. Tissue angiogenesis occurs to satisfy energy requirements and cellular sensors of metabolic imbalance coordinate vessel growth. In this regard, the classical pathways of the unfolded protein response activated under conditions of ER stress have recently been described to generate angiomodulatory or angiostatic signals. This review elaborates on the link between angiogenesis and ER stress and discusses the implications for diseases characterized by altered vascular homeostasis, such as cancer, retinopathies, and atherosclerosis.

  10. Cancer Immunotherapy of Targeting Angiogenesis

    Institute of Scientific and Technical Information of China (English)

    JianmeiHou; LingTian; YuquanWei

    2004-01-01

    Tumor growth and metastasis are angiogenesis-dependent. Anti-angiogenic therapy may be a useful approach to cancer therapy. This review discussed tumor angiogenesis and immunotherapy of targeting tumor angiogenesis from two main aspects: (1) active vaccination to induce effective anti-angiogenesis immunity; (2) passive immunotherapy with anti-pro-angiogenic molecules relevant antibody. Evidence from the recent years suggested that anti-angiogenic therapy should be one of the most promising approaches to cancer therapy.

  11. Effect of phosphatidylinositol 3-kinase in angiogenesis-related diseases%磷脂酰肌醇3-激酶在血管新生相关性疾病中的作用

    Institute of Scientific and Technical Information of China (English)

    权伟; 张丽莙

    2011-01-01

    @@ 血管新生参与了人体多种生理与病理过程,前者如创伤愈合,后者包括肿瘤、动脉粥样硬化(atherosclerosis,AS)、类风湿性关节炎(rheumatoid arthritis,RA)等多种疾病,血管新生与这些疾病的发生发展密切相关.磷脂酰肌醇3-激酶(phosphatidylinositol 3-kinase, PI3K)作为细胞内重要的信号蛋白,可介导细胞迁移、增殖与血管新生等多种生物学行为的信号转导.%Angiogenesis is involved in the pathological processes such as wound healing, atherosclerosis,rheumatoid arthritis and tumor, in which the pathogenesis and development are closely related to the new blood vessel formation. Phosphatidylinositol 3 - kinase ( PI3 K ), one of the important intracellular signaling proteins, mediates many signal transductions in cell migration, proliferation and angiogenesis. The activity of PI3 K and its signaling pathway play a unique role in atherogenesis, unstability of atherosclerotic plaque, tumor metastasis and recurrence, etc. This review summarizes the effect of PI3 K in angiogenesis - related diseases.

  12. Teaching Culture: The Challenges and Opportunities of International Public Relations.

    Science.gov (United States)

    George, Amiso M.

    2003-01-01

    Focuses on the challenges and opportunities for international public relations practice. Looks at current United States-Arab relations issues in international crisis communication. Discusses those issues, especially the role of culture and media. Proposes strategies including a case study that teachers can use to help students become effective…

  13. Promotion Begins with PR. A Public Relations Guide.

    Science.gov (United States)

    Maine Association of Vocational Administrators.

    This manual was developed to help vocational teachers and administrators in Maine to promote vocational education using a variety of techniques and media. Practical guidelines are offered for: (1) developing a plan for promotion and public relations; (2) compiling the facts; (3) developing media relations; (4) using printed and broadcast…

  14. Forholdet mellem public relations og marketing som ledelsesfunktioner

    Directory of Open Access Journals (Sweden)

    James E. Grunig

    1993-09-01

    Full Text Available I forsommeren 1993 tildelte Dansk Public Relations Forening årets PR- pris til mesterkommunikatøren Lars Larsen, Jysk Sengetøjslager/Larsen Rejser. I motiveringen hedder det, at Lars Larsen hædres for "en prisvær- dig Public Relations indsats, der kan motivere til en øget anvendelse af Public Relations i den danske forretningsverden". Blandt PR-foreningens medlemmer vakte pristildelingen en vis furore; et indlæg i foreningens blad PRspektiv invendte, at Lars Larsen driver "publicity" (dvs. et reklame- værktøj - "Præcis den slags PR, som vi i mange år har arbejdet på at distancere Public Relation-begrebet fra". Lars Larsen selv sagde, at han slet ikke skelner mellem Public Relations, PR og markedsføring. Et andet indlæg i bladet argumenterede for, at det ikke længere giver mening at adskille begreberne Public Relations og markedsføring, fordi grænsen mellem det offentlige og det private ude i virkeligheden er mere og mere flydende. James Grunigs artikel, der søger at afklare forholdet mellem PR og marketing teoretisk og praktisk, er derfor brændende aktuelt, ikke mindst for PR-fagets bestræbelser på at blive anerkendt som en respek- tabel profession. Den blev præsenteret som foredrag under Grunigs Dan- marksbesøg i marts 1993, er redigeret af Kim Schrøder og oversat fra engelsk af Kenja Henriksen.

  15. New image of psychiatry, mass media impact and public relations.

    Science.gov (United States)

    Jakovljević, Miro; Tomić, Zoran; Maslov, Boris; Skoko, Iko

    2010-06-01

    The mass media has a powerful impact on public attitudes about mental health and psychiatry. The question of identity of psychiatry as a medical profession as well as of the future of psychiatry has been the subject of much controversial discussion. Psychiatry today has the historical opportunity to shape the future of mental health care, medicine and society. It has gained in scientific and professional status by the tremendous increase of knowledge and treatment skills. Psychiatry should build up new transdisciplinary and integrative image of a specialized profession, promote it and make it public. Good public relations are very important for the future of psychiatry.

  16. The Harvard angiogenesis story.

    Science.gov (United States)

    Miller, Joan W

    2014-01-01

    I shall discuss the work of researchers at Harvard Medical School who came together in the early 1990s. Scattered across various Harvard-affiliated hospitals and research centers, these individuals were unified by their interest in ocular neovascularization. Together and separately, they investigated models of ocular neovascularization, exploring tumor angiogenesis in eye development and disease.

  17. How phototherapy affects angiogenesis

    Science.gov (United States)

    Dyson, Mary

    2007-02-01

    Angiogenesis is essential for normal growth, tissue repair and regeneration. Its stimulation accelerates repair and regeneration including wound healing where these processes are delayed. Its inhibition can reduce the rate of growth of solid tumors. Phototherapy can accelerate the resolution of acute inflammation with the result that the proliferative phase of tissue repair, when angiogenesis occurs, begins earlier than in sham-irradiated controls. Evidence that angiogenesis is enhanced in dermal repair, tendon repair and bone regeneration in rodents is presented. The cellular mechanisms that control angiogenesis involve the interaction of endothelial cells, macrophages, pericytes and other cells in response, for example, to changes in the availability of oxygen in the local environment. Pericytes and macrophages modulate endothelial cell proliferation; pericytes guide endothelial cell migration. The stimulation of endothelial cell proliferation in vitro following exposure to red (660 nm) and infrared (820 nm) radiation, 15 mW, at 2-8 J/cm2 is presented. 1J/cm2 was ineffective. 820 nm irradiation, 15 mW, at 8 J/cm2 was observed to inhibit pericyte proliferation in vitro. Indirect effects on endothelial cell and pericyte proliferation followed stimulation of soluble mediator production by macrophages following exposure to red and infrared radiation. The potential clinical significance of the results obtained is discussed and the necessity of clinical trials emphasized.

  18. Peer relations, adolescent behavior, and public health research and practice.

    Science.gov (United States)

    Crosnoe, Robert; McNeely, Clea

    2008-01-01

    Peer relations are central to adolescent life and, therefore, are crucial to understanding adolescents' engagement in various behaviors. In recent years, public health research has increasingly devoted attention to the implications of peer relations for the kinds of adolescent behaviors that have a direct impact on health. This article advocates for a continuation of this trend. With this aim, we highlight key themes in the rich literature on the general developmental significance of adolescent-peer relations, provide an overview of how these themes have been incorporated into public health research and practice, and suggest future avenues for peer-focused public health research that can inform adolescent health promotion in the United States.

  19. Ischemia-driven angiogenesis.

    Science.gov (United States)

    Dor, Y; Keshet, E

    1997-11-01

    New blood vessels usually develop in places where they are most needed. A prime example of neovascularization representing a positive feedback response to insufficient perfusion is the development of collateral blood vessels in the ischemic myocardium and leg. The recent discoveries of hypoxia-inducible transcription and angiogenic factors have provided important mechanistic links between the metabolic consequences of ischemia and compensatory angiogenesis. Vascular endothelial growth factor (VEGF) has emerged as the key mediator of ischemia-driven angiogenesis. Environmental stresses, including hypoxia, hypoglycemia, and hypoferremia, upregulate VEGF expression at both the transcriptional and posttranscriptional levels. VEGF acts in turn on adjacent vascular beds expressing cognate receptors and induces sprouting and capillary growth toward the ischemic tissue. In addition to expanding the vasculature at sites where existing vessels have been occluded or obliterated, VEGF also functions to match the vascular density according to development and physiologic increases in oxygen consumption. Fine adjustment of the vasculature includes a step of oxygen-regulated vascular pruning mediated by VEGF in its capacity as a survival factor for newly formed vessels. Pathologic settings of ischemia-driven angiogenesis include a major component of stress-induced angiogenesis during tumor neovascularization and abnormal vessel growth associated with retinopathies. The latter represents an excessive angiogenic response to conditions of severe retinal ischemia. Further insights into the mechanism of stress-induced angiogenesis are likely to suggest new ways to augment growth of collateral vessels and to restrain unwarranted neovascularization in tumors and retinopathies. (Trends Cardiovasc Med 1997;7:289-294). © 1997, Elsevier Science Inc.

  20. The Ambivalent Relations between Bureaucracy and Public Innovation:

    DEFF Research Database (Denmark)

    Schultz Larsen, Troels

    2015-01-01

    Building on a growing body of literature on public innovation and the rediscovery of bureaucracy, this article explores the relations between innovation and bureaucracy. A framework for studying innovation in a bureaucratic context is developed and its relevance assessed through a case study...... of the successful implementation but failed diffusion of an innovation project. The case study demonstrates how a bureaucratic context represents not only barriers to innovation but also a number of complex drivers. The outline of these ambivalent relations is used to tease out the Janus face of the new spirit...... of innovation in public administration....

  1. Branding your medical practice with effective public relations.

    Science.gov (United States)

    Trent, Nancy

    2009-01-01

    Whether you think of it as your image, your standing in the community, or your reputation, your medical practice is also a brand. While many organizations, companies, products, and services are known for specific attributes that make them stand out from competitors, most use a combination of marketing disciplines to communicate who and what they are to their customers, consumers, and patients. Public relations is often considered the most powerful, cost-effective, and efficacious of the marketing disciplines, surpassing advertising, promotion, and direct mail in molding and developing brands. Your practice can benefit from a well-crafted branding public relations program.

  2. Effectively selling astronomy to the public -- fusing lessons learned from education, entertainment, advertising and public relations

    Science.gov (United States)

    Pallone, Arthur; Day, Jacque

    2010-03-01

    A great celestial story is only as effective as the teller of the tale. With passion and knowledge at the helm, we must search for ways to pass on enthusiasm to others while conveying sound science. Based on our experiences, we present an integrated approach -- one that borrows elements from education, entertainment, advertising, and public relations -- to choose an event, hook and keep the public's attention while making them want more, and provide some tips for increasing media presence.

  3. Evaluating Internal Public Relations Using the Critical Incident Technique

    NARCIS (Netherlands)

    Koning, K.H.; Jong, de M.D.T.; Vuuren, van H.A.

    2015-01-01

    Although the critical incident technique (CIT) is one of the current methods in communication audits, little is known about the way it works. The validity of the CIT in the context of internal public relations depends on 3 assumptions: that participants can describe discrete communication events, th

  4. A first look for parameters of public relations in Europe

    NARCIS (Netherlands)

    van Ruler, A.A.; Vercic, D.; Buetschi, G.; Flodin, B.

    2004-01-01

    Teaching of public relations in Europe is largely U.S. oriented. A study has been conducted to determine whether this also applies to the practical and academic approaches in this area. A Delphi panel, consisting of experts in research, education, or both from countries in Europe, identified four ch

  5. School Public Relations: Communicating to the Community. Fastback 182.

    Science.gov (United States)

    Kinder, J. A.

    To help school administrators, this handbook suggests guidelines for establishing a school public relations (PR) program and offers techniques used by schools to communicate with the community. The introductory section stresses the need for school PR, given recent political, financial, and demographic changes. The second section outlines a master…

  6. A Balanced Scorecard Approach to Public Relations Management Assessment.

    Science.gov (United States)

    Fleisher, Craig S.; Mahaffy, Darren

    1997-01-01

    Describes a new managerial approach to assessing public relations/communications (PR/C) performance using a "balanced scorecard." Reviews the current state of PR/C management assessment; illustrates the balanced scorecard framework; highlights its strengths and weaknesses; describes the process of applying the scorecard to PR/C units;…

  7. Community College Journalism Professors Should Underscore Public Relations.

    Science.gov (United States)

    Martinson, David L.

    1993-01-01

    Examines the importance of including instruction in public relations (PR) in journalism curricula. Discusses common misconceptions regarding PR, the evolution of the field, and the social science aspects and ultimate goals of PR. Indicates that it is important to provide students with a balanced introduction to PR. (MAB)

  8. Crisis Communication and Management: Surviving a Public Relations Crisis

    Science.gov (United States)

    Eramo, Eric M.

    2009-01-01

    Crisis management, or crisis communication, is never a good thing for a business to experience. It is, however, a public relations' professional moment to shine and put their honed skills to good use. A good crisis management plan is not only action during the crisis but preparation and reflection. Hiring a PR firm that deals with crisis…

  9. Broadening Research on Communication and School Public Relations

    Science.gov (United States)

    Kowalski, Theodore J.

    2005-01-01

    Effective communication and public relations are recognized as core competencies for school administration as evidenced by national standards guiding preparation and licensing in most states. Even so, surprisingly little research has been conducted by doctoral students and professors on these two subjects. This article presents a case for…

  10. Teaching Teamwork to Public Relations Students: Does It Matter?

    Science.gov (United States)

    Baker-Schena, Lori

    2011-01-01

    Purpose: The first purpose of this study was to determine the extent to which students in university capstone public relations classes who receive teamwork training demonstrate effective team behaviors, produce quality work, experience satisfaction in the teamwork process, and engender client satisfaction. The second purpose was to determine the…

  11. Digital Public Relations: E-Marketing's Big Secret

    Science.gov (United States)

    Gifford, Janet

    2010-01-01

    Online programs and courses are established presences in higher education, and so are processes such as online registration. Prospective students routinely turn to the web for information to help them decide on the most appropriate programs for their situation. Digital public relations (digital PR) is rapidly becoming one of the cornerstones of an…

  12. The Effects of Public Relations Messages about Corporate Social Responsibility.

    Science.gov (United States)

    Reeves, Byron; Ferguson-Dethorne, Mary Ann

    To determine whether public relations messages generated from three different corporate social responsibility philosophies would have different effects on attitudes and behavioral intentions toward a corporation, 147 college students participated in an experiment. The three social responsibility philosophies were defined as: a "profit" concept,…

  13. TRANSFORMATION OF THE INTERACTION OF PUBLIC RELATIONS AND PUBLIC DIPLOMACY WITH AN AUDIENCE

    Directory of Open Access Journals (Sweden)

    Natalia Aleksandrovna Kontsevaya

    2015-01-01

    Full Text Available The article considers the phenomenon of transformation of the interaction of public relations and public diplomacy with an audience. Since 1980-s, experts have noted strengthening of the role of public in the communication process of PR and Public Diplomacy. Analysis of the work in this direction has revealed changes in the communication world order, due to several factors, which caused the transformation. These factors are: globalization of society (active tourism, developing from the end of the ХХ century, communication without geographical boundaries allowing people to send and receive information outside the country, technological development (penetration of Internet, in particular social networks, in the communication process and changed attitude of the audience to information (also due to the widespread use of social networks, allowing open access to personal information for strangers. Experts evaluate positively the changes in public relations and public diplomacy that have occurred under the influence of transformation of their interaction with the audience. The analysis made in the article is based on the works of renowned experts in this field.

  14. Authors' opinions on publication in relation to annual performance assessment

    Directory of Open Access Journals (Sweden)

    Hemmelgarn Brenda R

    2010-03-01

    Full Text Available Abstract Background In the past 50 years there has been a substantial increase in the volume of published research and in the number of authors per scientific publication. There is also significant pressure exerted on researchers to produce publications. Thus, the purpose of this study was to survey corresponding authors in published medical journals to determine their opinion on publication impact in relation to performance review and promotion. Methods Cross-sectional survey of corresponding authors of original research articles published in June 2007 among 72 medical journals. Measurement outcomes included the number of publications, number of authors, authorship order and journal impact factor in relation to performance review and promotion. Results Of 687 surveys, 478 were analyzed (response rate 69.6%. Corresponding authors self-reported that number of publications (78.7%, journal impact factor (67.8% and being the first author (75.9% were most influential for their annual performance review and assessment. Only 17.6% of authors reported that the number of authors on a manuscript was important criteria for performance review and assessment. A higher percentage of Asian authors reported that the number of authors was key to performance review and promotion (41.4% versus 7.8 to 22.2%. compared to authors from other countries. Conclusions The number of publications, authorship order and journal impact factor were important factors for performance reviews and promotion at academic and non-academic institutes. The number of authors was not identified as important criteria. These factors may be contributing to the increase in the number of authors per publication.

  15. Perception of Journalists on the Role of Public Relations

    Directory of Open Access Journals (Sweden)

    Nicoleta Grasu

    2014-12-01

    Full Text Available The relations with the media are the main activity performed by the public relations specialists for maintaining a positive image of the organization they represent. This relation between public relations and journalists can become, sometimes, a conflicting one, but both of them admit that they need each other. On the on hand, communication specialists try to satisfy journalists‟ information needs, and on the other hand, the journalists satisfy PR-ists needs to put in a favorable light the organization they represent. In this study we intend to identify the opinion of journalists on public relations and spokesperson in relation to the work of the journalist and also to identify the reasons of journalists for not trust the profession of media relationist. The questionnaire was applied in the range 1 to 20 March 2014. The sampling was non-probabilistic one, the only criterion for selection of respondents being the status of journalist. The questionnaire answered 50 journalists from central and local press. In terms of the positions held by the respondents, the sample is as follows: 12% are director, 24% have editor function, 14% are editors and 34% are reporters.

  16. International Public Relations in the EU: Development Cooperation Public Opinion and Public Policies

    Directory of Open Access Journals (Sweden)

    Victor Negrescu

    2011-05-01

    Full Text Available In the context of the growing importance of the cooperation for development in the European Union and the appearance of a common growing public opinion agreement supporting this kind of initiatives, it is necessary to understand if we can talk today about a true common European consensus. Still covered on intergovernmental level and considered to be a part of the national foreign policies, EU development aid is still far from reaching the maximum of its efficiency. In this paper we try to introduce a new evaluation method of the cooperation for development policies and interpretation of the degree of communitarisation of the national policies that will enable us to appreciate the stages that have to be completed by the member countries but also by the EU to realize a completely uniform European assistance strategy and of the activities, so necessary for raising the efficiency of the funds allocated by the EU, but also in the perspective of achieving the Millennium Development Goals.

  17. Angiogenesis and the inception of pregnancy

    NARCIS (Netherlands)

    Kapiteijn, Kitty

    2006-01-01

    Vascular maladaptation prior and during implantation may lead to serious complications during pregnancy, perinatally, but also later in life (Barker hypothesis). The consequences later in life often appear to be related to endothelial dysfunction. Angiogenesis, the formation of new blood vessels fro

  18. Public relations in risk communication: risk pr. The importance of public relations for risk communication; Public Relations in der Risikokommunikation: Risiko-PR. Die Bedeutung von Public Relations fuer die Risikokommunikation

    Energy Technology Data Exchange (ETDEWEB)

    Lehmann, K.

    2001-07-01

    Risks have become a central problem of our time, as is reflected in concepts like 'society at risk' and 'anti-technological attitude', in group protest against risks and against those who cause them, and last but not least in the critical attitude of the media. Against this background, organisations must needs enter the public discussion and be able to communicate professionally and convincingly in order to ensure their own success and further existence. The book describes the basic problems of risk research and risk communications and discusses inhowfar, and how, public relations strategies and instruments can help here. [German] Risiken werden verstaerkt zum Problem unserer Zeit. Das belegen nicht nur Begriffe wie 'Risikogesellschaft' und 'Technikfeindlichkeit', die in letzter Zeit an Bedeutung gewonnen haben, sondern auch und vor allem nachhaltige Proteste von engagierten Gruppierungen gegen Risiken und deren Verursacher oder auch die kritische Berichterstattung der Medien. Vor diesem Hintergrund ist es fuer Organisationen erforderlich, in die oeffentliche Auseinandersetzung um Risiken einzusteigen und hier professionell und ueberzeugend zu kommunizieren, um den Organisationserfolg und Organisationsbestand zu sichern. Die vorliegende Arbeit beschreibt die Grundprobleme der Risikoforschung und Risikokommunikation und diskutiert, ob und inwieweit Public Relations bei der Loesung dieser Probleme helfen koennen, da insbesondere Public Relations gezielt Strategien und Instrumente nutzen, um beispielsweise den Wissensstand der Oeffentlichkeit zu verbessern und den Dialog mit relevanten Teiloeffentlichkeiten zu foerdern. (orig.)

  19. Endostatin derivative angiogenesis inhibitors

    Institute of Scientific and Technical Information of China (English)

    ZHENG Meng-jie

    2009-01-01

    Objective To throw light on the superiority of the anti-angiogenesis activity of endostatin (ES) derivatives by reviewing the recent progress in the field of ES molecular structure modification.Data sources The data used in this article were mainly from PubMed with relevant English articles published from 1971 to May 2008.The search terms were "endostatin" and "angiothesis".Study selection Articles involved in the ES molecular structure modification and the original milestone articles were selected.Results A number of ES derivatives were designed and studied to improve its clinical relevance.The modified ES with polyethylene glycol (PEG),low molecular weight heparin (LMWH) and IgG Fc domain extended the circulation half-life.Meanwhile the recombinant ESs showed more potent anti-tumor activity than native ES in mouse xenografts.Mutated ES also changed its anti-angiogenesis activity.Conclusions The anti-angiogenesis treatment remains a promising tumor therapeutic strategy.New ES derivatives would be a good choice to meet the future challenge on clinical application of ES.

  20. KSHV-Mediated Angiogenesis in Tumor Progression

    Directory of Open Access Journals (Sweden)

    Pravinkumar Purushothaman

    2016-07-01

    Full Text Available Human herpesvirus 8 (HHV-8, also known as Kaposi’s sarcoma-associated herpesvirus (KSHV, is a malignant human oncovirus belonging to the gamma herpesvirus family. HHV-8 is closely linked to the pathogenesis of Kaposi’s sarcoma (KS and two other B-cell lymphoproliferative diseases: primary effusion lymphoma (PEL and a plasmablastic variant of multicentric Castleman’s disease (MCD. KS is an invasive tumor of endothelial cells most commonly found in untreated HIV-AIDS or immuno-compromised individuals. KS tumors are highly vascularized and have abnormal, excessive neo-angiogenesis, inflammation, and proliferation of infected endothelial cells. KSHV directly induces angiogenesis in an autocrine and paracrine fashion through a complex interplay of various viral and cellular pro-angiogenic and inflammatory factors. KS is believed to originate due to a combination of KSHV’s efficient strategies for evading host immune systems and several pro-angiogenic and pro-inflammatory stimuli. In addition, KSHV infection of endothelial cells produces a wide array of viral oncoproteins with transforming capabilities that regulate multiple host-signaling pathways involved in the activation of angiogenesis. It is likely that the cellular-signaling pathways of angiogenesis and lymph-angiogenesis modulate the rate of tumorigenesis induction by KSHV. This review summarizes the current knowledge on regulating KSHV-mediated angiogenesis by integrating the findings reported thus far on the roles of host and viral genes in oncogenesis, recent developments in cell-culture/animal-model systems, and various anti-angiogenic therapies for treating KSHV-related lymphoproliferative disorders.

  1. KSHV-Mediated Angiogenesis in Tumor Progression

    Science.gov (United States)

    Purushothaman, Pravinkumar; Uppal, Timsy; Sarkar, Roni; Verma, Subhash C.

    2016-01-01

    Human herpesvirus 8 (HHV-8), also known as Kaposi’s sarcoma-associated herpesvirus (KSHV), is a malignant human oncovirus belonging to the gamma herpesvirus family. HHV-8 is closely linked to the pathogenesis of Kaposi’s sarcoma (KS) and two other B-cell lymphoproliferative diseases: primary effusion lymphoma (PEL) and a plasmablastic variant of multicentric Castleman’s disease (MCD). KS is an invasive tumor of endothelial cells most commonly found in untreated HIV-AIDS or immuno-compromised individuals. KS tumors are highly vascularized and have abnormal, excessive neo-angiogenesis, inflammation, and proliferation of infected endothelial cells. KSHV directly induces angiogenesis in an autocrine and paracrine fashion through a complex interplay of various viral and cellular pro-angiogenic and inflammatory factors. KS is believed to originate due to a combination of KSHV’s efficient strategies for evading host immune systems and several pro-angiogenic and pro-inflammatory stimuli. In addition, KSHV infection of endothelial cells produces a wide array of viral oncoproteins with transforming capabilities that regulate multiple host-signaling pathways involved in the activation of angiogenesis. It is likely that the cellular-signaling pathways of angiogenesis and lymph-angiogenesis modulate the rate of tumorigenesis induction by KSHV. This review summarizes the current knowledge on regulating KSHV-mediated angiogenesis by integrating the findings reported thus far on the roles of host and viral genes in oncogenesis, recent developments in cell-culture/animal-model systems, and various anti-angiogenic therapies for treating KSHV-related lymphoproliferative disorders. PMID:27447661

  2. Public relations as a tool of science communication with society

    Directory of Open Access Journals (Sweden)

    Andrzej H. Jasinski

    2010-01-01

    Full Text Available In the field of science, Central and East European countries (CEECs have inherited various relics from the past, among them: -bad communication between science and society, -low level of public understanding of science (PUS, -weak co-operation between the science sphere and the production sphere, -small scale of science commercialisation, -practically non-existent infrastructure of scientific and technological knowledge flows in society. At present, the market reforms in CEECs are far advanced. So now, the main direction in their developments is to build the knowledge-based economy/society. Moreover, the science sector has been divided into three separate sub-sectors: (1 Higher Education, (2 Academies of Sciences and (3 Industrial R&D. Higher education institutions together with academy of sciences¿ research institutes constitute so-called academic science. In reforming our countries towards modern market economies, academic science faces numerous challenges. Among them, there is a challenge: How to communicate better with society? There are various tools of such communication. One of them is public relations (PR. The main aim of this paper is to prove a big potential role of public relations as a communication tool between academic science and society, with a special reference to CEECs. Poland will here be a case-study. The following issues will be analyzed in the paper: 1. The role of science communication: A brief survey of literature 2. Public relations as an element of science communication 3. Polish experiences: A short evaluation 4. A desired role of public relations 5. Conclusion.

  3. Hydrogels for therapeutic cardiovascular angiogenesis.

    Science.gov (United States)

    Rufaihah, Abdul Jalil; Seliktar, Dror

    2016-01-15

    Acute myocardial infarction (MI) caused by ischemia is the most common cause of cardiac dysfunction. While growth factor or cell therapy is promising, the retention of bioactive agents in the highly vascularized myocardium is limited and prevents sustained activation needed for adequate cellular responses. Various types of biomaterials with different physical and chemical properties have been developed to improve the localized delivery of growth factor and/or cells for therapeutic angiogenesis in ischemic tissues. Hydrogels are particularly advantageous as carrier systems because they are structurally similar to the tissue extracellular matrix (ECM), they can be processed under relatively mild conditions and can be delivered in a minimally invasive manner. Moreover, hydrogels can be designed to degrade in a timely fashion that coincides with the angiogenic process. For these reasons, hydrogels have shown great potential as pro-angiogenic matrices. This paper reviews a few of the hydrogel systems currently being applied together with growth factor delivery and/or cell therapy to promote therapeutic angiogenesis in ischemic tissues, with emphasis on myocardial applications.

  4. Salaries of New Superintendents: A Public Relations Concern for Many Public School Boards

    Science.gov (United States)

    Young, I. Phillip

    2007-01-01

    Salaries for new superintendents form a highly visible factor that has direct implications for school-community public relations. To provide a means for guiding school board members and to provide a format for justifying salaries, a model is presented that serves both purposes. Within this model, attention is afforded to specifying a relevant…

  5. Analytical and critical thinking skills in public relations

    Directory of Open Access Journals (Sweden)

    Dalibor Jakus

    2014-12-01

    Full Text Available This article presents more or less independent reasons why analytical and critical thinking skills should be essential part of public relations. Generally, it is considered that the analytical and critical thinking skills are part of public relations, as well as creative thinking, but they should be considered separately and given the codes of ethics of the profession used as initial criteria. For the purpose of the study, in this article is presented the result of the survey in which determine importance of using analytical and critical thinking skills in the implementation of PR projects. The second aim in the survey was to identify the target audience and how they react to the placed information.

  6. Machismo, public health and sexuality-related stigma in Cartagena.

    Science.gov (United States)

    Quevedo-Gómez, María Cristina; Krumeich, Anja; Abadía-Barrero, César Ernesto; Pastrana-Salcedo, Eduardo; van den Borne, Hubertus

    2012-01-01

    This paper reports on an ethnographic study in Cartagena, Colombia. Over a seven-month fieldwork period, 35 men and 35 women between 15 and 60 years of age discussed the social context of HIV/AIDS through in-depth interviews, life histories and drawing. Participants considered the transgression of traditional gender roles as prescribed by machismo a major risk factor for HIV infection. In addition, they integrated public-health concepts of risk groups with these long-standing constructions of gender roles and sexuality-related stigma to create the notion of 'AIDS carriers'. The bricolage between machismo, public health and sexuality-related stigma that participants created and consequent preventive measures (based on an avoidance of sex with people identified as 'AIDS carriers') was a dynamic process in which participants were aware that changes in this particular interpretation of risk were necessary to confront the local epidemic.

  7. A Comparative Analysis of Internal Communication and Public Relations Audits. State of the Art.

    Science.gov (United States)

    Dozier, David M.; Hellweg, Susan A.

    A review of current literature regarding the state of the art in the conduct of internal communication and public relations audits by public relations practitioners reveals that these two related measurement activities are of considerable importance to the practice of public relations. Public relations audits are concerned with exploratory…

  8. Strategic Public Relations and University Entrepreneurship in Present European Context

    Directory of Open Access Journals (Sweden)

    Andreea RĂCEANU

    2016-05-01

    Full Text Available Mostly theoretical and following a descriptive - normative logic, with a specific focus on the models of higher education institutions and practices, the present paper addresses the subject of entrepreneurship within higher education area, in relation with current European policy context regarding higher education and university entrepreneurship. It proposes a strategic public relations framework as an integrating effective approach for actual opportunities and challenges that universities deal with presently. Various theoretical approaches and concrete actions emerged, from the complex perspectives of triple helix (organic relationships and interactions between universities, industry and government to particular aims regarding the development of knowledge-based economy or to the European Union knowledge triangle initiatives (education-research-innovation. The role of universities is expected to be broader and its actions should be characterized by both responsibility and pragmatism within the context of sustainable decision making. However, mostly in practice, there are limitations and criticism regarding a convergent model of entrepreneurial university, even more in relation with issues related to ethics of teaching and research and especially for universities with social and humanistic profiles. In this context, a viable solution could come from the area of public relations, undertaken in their most advanced form: as strategic approach linking decision making processes, stakeholders’ needs and interests and assuming long term responsibility. The main aim and originality component of this paper is to propose and support such an approach presented both verbally and trough graphical modelling.

  9. Expression of lysophosphatidic acid receptor 1 and relation with cell proliferation, apoptosis, and angiogenesis on preneoplastic changes induced by cadmium chloride in the rat ventral prostate.

    Directory of Open Access Journals (Sweden)

    Riánsares Arriazu

    Full Text Available BACKGROUND: Lysophosphatidic acid (LPA is a phospholipid growth factor involved in cell proliferation, differentiation, migration, inflammation, angiogenesis, wound healing, cancer invasion, and survival. This study was directed to evaluate the immunoexpression of LPA-1, cell proliferation, apoptosis, and angiogenesis markers in preneoplastic lesions induced with cadmium chloride in rat prostate. METHODS: The following parameters were calculated in ventral prostate of normal rats and rats that received Cd in drinking water during 24 months: percentages of cells immunoreactive to LPA-1 (LILPA1, PCNA (LIPCNA, MCM7 (LIMCM7, ubiquitin (LIUBI, apoptotic cells (LIAPO, and p53 (LIp53; volume fraction of Bcl-2 (VFBcl-2; and length of microvessels per unit of volume (LVMV/mm3. Data were analyzed using Student's t-test and Pearson correlation test. RESULTS: The LILPA1 in dysplastic lesions and normal epithelium of Cd-treated rats was significantly higher than those in the control group. Markers of proliferation were significantly increased in dysplastic lesions, whereas some apoptotic markers were significantly decreased. No significant differences between groups were found in VFBcl-2. Dysplastic lesions showed a significant increase of LIp53. The length of microvessels per unit of volume was elevated in dysplastic acini. Statistically significant correlations were found only between LILPA1 and LIUBI. CONCLUSIONS: Our results suggest that LPA-1 might be implicated in dysplastic lesions induced by cadmium chloride development. More studies are needed to confirm its potential contribution to the disease.

  10. Strategi public relations dalam manajemen krisis (studi deskriptif kualitatif strategi manajemen krisis divisi public relations pt pln (persero) wilayah sumatera utara)

    OpenAIRE

    Manurung, Tia Malinda

    2014-01-01

    Penelitian ini berjudul Strategi Public Relations dalam Manajemen Krisis (Studi Deskriptif Kualitatif Strategi Manajemen Krisis Divisi Public Relations PT PLN (Persero) Wilayah Sumatera Utara). Penelitian ini bertujuan untuk mengetahui pemetaan krisis yang terjadi di PT PLN (Persero) Wilayah Sumatera Utara, untuk mengetahui strategi manajemen krisis yang dilakukan public relations PT PLN (Persero) Wilayah Sumatera Utara. Public Relations merupakan kegiatan berkesinambungan dari usaha-usaha u...

  11. Strategi Divisi Public Relations dalam Manajemen Krisis (Studi Deskriptif Kualitatif Strategi Manajemen Krisis Divisi Public Relations PT PLN (Persero) Wilayah Sumatera Utara)

    OpenAIRE

    Manurung, Tia Malinda

    2015-01-01

    Penelitian ini berjudul Strategi Public Relations dalam Manajemen Krisis (Studi Deskriptif Kualitatif Strategi Manajemen Krisis Divisi Public Relations PT PLN (Persero) Wilayah Sumatera Utara). Penelitian ini bertujuan untuk mengetahui pemetaan krisis yang terjadi di PT PLN (Persero) Wilayah Sumatera Utara, untuk mengetahui strategi manajemen krisis yang dilakukan public relations PT PLN (Persero) Wilayah Sumatera Utara. Public Relations merupakan kegiatan berkesinambungan dari usaha-usaha u...

  12. Public Relations and Technology Transfer Offices: An Assessment of US Universities' Relations with Media and Government

    Science.gov (United States)

    Haney, James M.; Cohn, Andrew

    2004-01-01

    This article discusses the importance for technology transfer offices of sound media and government relations strategies. It reports the results of a nationwide electronic survey in the USA and interviews with technology transfer managers on how they handle public relations issues in their offices. Strengths and weaknesses of their communication …

  13. THE INFLUENCE OF MARKETING PUBLIC RELATION AND SERVICE QUALITY ON CORPORATE IMAGE THROUGH PUBLIC OPINION: STUDIES AT MANDIRI BANK

    OpenAIRE

    Vera Suciyati

    2015-01-01

    This research aims to analyze the influence of marketing public relation and service quality at Bank Mandiri on corporate image through public. Convenience sampling method has been selected in order to obtain the data in this study. The analysis method that used was the path analysis. The research result had shown that: marketing public relation and service quality have significant influence simultaneously and partially on public opinion on the first structure equation. The second structure e...

  14. The importance planning of public relations in tourist organizations’ communication

    Directory of Open Access Journals (Sweden)

    Maria Carmenl IORDACHE

    2009-12-01

    Full Text Available Accomplishing efficient communication on tourist markets means efficiently developing and operating a communication system, that is designing and implementing an adequate structure of communication activities. Tourist organizations must have a communication strategy according to communication activities’ target, global objectives pursued, communication targets aimed, communication media used and contents of transmitted messages and, last but not least, resources allocated to implement communicational procedures. In order to attract consumers on a highly competitive market, there are several management-marketing instruments of which some are public relations whose role is to create a positive image of a tourist organization and, implicitly, of its products and services.

  15. Marketing and public relations in the emergency department.

    Science.gov (United States)

    Mayer, T A; Tilson, W; Hemingway, J

    1987-02-01

    This article outlines the elements of successful ED marketing, as well as providing definitions for terms used within the marketing process. In today's competition and rapidly changing environment, marketing and public relations are tools that every ED Medical Director may want to consider. Because the marketing process requires a great deal of time and effort, as well as a high degree of intellectual honesty, it should never be entered into without a strong commitment. However, marketing the ED can be among the most productive, stimulating, and gratifying experiences for the ED Medical Director, the emergency department physicians, and all ED service personnel.

  16. Models of political public relations: Testing the situation in Catalonia

    Directory of Open Access Journals (Sweden)

    Dr. Jordi Xifra Triadú

    2008-01-01

    Full Text Available The idea that political communication strategies are an application of marketing strategies to political field is today commonly shared by specialists. For them public relations is viewed like a set of techniques that serves political parties and other actors of the political scene, concentrated on media relations. This instrumental perspective is not in keeping with structural dimension of public relations in political activity and communication of his actors: political parties, pressure groups and political leaders. In this point of view, during managing periods of governance or opposition and during electoral campaigns, the most applied communication form by political parties is structured in accordance with the major public relations models: press agent model, public information model, two way asymmetrical model, and two way symmetrical model. This research prove hypothesis in Catalonia according the results of a quantitative survey focused on inside professionals who provide services for the seven main political parties in this Spanish Autonomous Community.RESUMEN:La idea de que las estrategias de comunicación política constituyen una aplicación de las estrategias del marketing al ámbito político es hoy comúnmente compartida por los analistas. Para éstos, las relaciones públicas son percibidas como un conjunto de técnicas al servicio de los partidos políticos y de otros actores de la escena política concentradas en las relaciones con la prensa. Esta perspectiva instrumental no concuerda con la dimensión estructural de las relaciones públicas en la actividad política y comunicativa de sus actores: partidos políticos, grupos de presión y líderes. Desde este punto de vista, tanto en los periodos de gestión u oposición como en los electorales, la forma comunicativa más aplicada por los partidos políticos se estructura de acuerdo con los modelos tradicionales de las relaciones públicas: agente de prensa, información p

  17. Multifunctional interleukin-1beta promotes metastasis of human lung cancer cells in SCID mice via enhanced expression of adhesion-, invasion- and angiogenesis-related molecules.

    Science.gov (United States)

    Yano, Seiji; Nokihara, Hiroshi; Yamamoto, Akihiko; Goto, Hisatsugu; Ogawa, Hirohisa; Kanematsu, Takanori; Miki, Toyokazu; Uehara, Hisanori; Saijo, Yasuo; Nukiwa, Toshihiro; Sone, Saburo

    2003-03-01

    We examined whether interleukin-1 (IL-1), a multifunctional proinflammatory cytokine, progresses or regresses metastasis of lung cancer. Exogenous IL-1beta enhanced expression of various cytokines (IL-6, IL-8, and vascular endothelial growth factor (VEGF)) and intracellular adhesion molecule-1 (ICAM-1) by A549, PC14, RERF-LC-AI, and SBC-3 cells expressing IL-1 receptors. A549 cells transduced with human IL-1beta-gene with the growth-hormone signaling-peptide sequence (A549/IL-1beta) secreted a large amount of IL-1beta protein. Overexpression of IL-1beta resulted in augmentation of expression of the cytokines, ICAM-1, and matrix metalloproteinase-2 (MMP-2). A549/IL-1beta cells intravenously inoculated into severe combined immunodeficiency (SCID) mice distributed to the lung more efficiently and developed lung metastasis much more rapidly than did control A549 cells. Treatment of SCID mice with anti-IL-1beta antibody inhibited formation of lung metastasis by A549/IL-1beta cells. Moreover, A549/IL-1beta cells inoculated in the subcutis grew more rapidly, without necrosis, than did control A549 cells, which produced smaller tumors with central necrosis, suggesting involvement of angiogenesis in addition to enhanced binding in the high metastatic potential of A549/IL-1beta cells. Histological analyses showed that more host-cell infiltration, fewer apoptotic cells, more vascularization, and higher MMP activity were observed in tumors derived from A549/IL-1beta cells, compared with tumors derived from control A549 cells. These findings suggest that IL-1beta facilitates metastasis of lung cancer via promoting multiple events, including adhesion, invasion and angiogenesis.

  18. MANAJEMEN PUBLIC RELATIONS PENDIDIKAN ISLAM (Kajian Tematik Al Qur’an dan Al Hadits

    Directory of Open Access Journals (Sweden)

    Dian Iskandar Jaelani

    2014-11-01

    Full Text Available Public Relations (PR has two senses. First, in terms of public relations as communication techniques. And second, public relations as a method of communication. The concept of Public Relations with respect to understanding through knowledge creation activities, and through these activities that impact the changes will appear. Public Relations itself is a combination of various immunization and included in the ranks of the social sciences such as political science, economics, history, psychology, sociology, communication and others.

  19. PUBLIC RELATION BASED MODEL OF INTEGRATED MARKETING COMMUNICATIONS

    Directory of Open Access Journals (Sweden)

    Ljupka Naumovska

    2016-12-01

    Full Text Available The marketing communications industry and theory are facing rapid changes in accordance with global business and society fluctuations. Global and local market conditions are constantly varying and thus creating hardly predictable environment. The most implemented tool for marketing communications – advertising, is losing its power for effective communications; customers are becoming over-advertised and resistant to traditional advertising stimuli. Advertising, as one-way communication mass media tool is no longer effective as previously, hence can no longer fulfill the role of leading marketing mix tool. Therefore, the necessity for altering the structure of the traditional marketing communication mix elements, emphasizing the role of other elements but advertising, with more personalized and interactive functions. One method for improvement of marketing communication’s mix efficiency is by reallocation the leading role of advertising with public relations. The practice of public relations tools can ensure higher level of transparency in internal and external organizational communications and thus can certify more effective marketing communication. The theoretical research is supported with qualitative research of business segment by conducting a detailed interview for the marketing communication practice.

  20. Public Relations dan Masyarakat dalam Memacu Pertumbuhan Pariwisata

    Directory of Open Access Journals (Sweden)

    Yuanita Safitri

    2015-07-01

    Full Text Available Tourism is an important determinant for a regions economic growththe higher income from tourism, the higher its gross regional domestic product. To be successful in exposing potential tourism sites, a region does not only depend on the beauty of the nature but also how to access the sites, on-site accommodation and the mutual relationship between local government and local community.The fact is many regions have difficulties in developing mutual relationship between local government and local community. It means what most important is how the tourism industry is being managed. One most important aspect of managing the tourism industry is the cooperation and communication between the local community and the government. This article aims to discuss how public relations and the local community work to stimulate tourism growth in a synergy. Using descriptive qualitative method, this article recommends a model of communication strategyin which the local community serves mainly as the tourisms public relation agents, and also serves as a reference method in evaluating a local governments communication strategies in regional tourism industry.

  1. THE INFLUENCE OF MARKETING PUBLIC RELATION AND SERVICE QUALITY ON CORPORATE IMAGE THROUGH PUBLIC OPINION: STUDIES AT MANDIRI BANK

    Directory of Open Access Journals (Sweden)

    Vera Suciyati

    2015-09-01

    Full Text Available This research aims to analyze the influence of marketing public relation and service quality at Bank Mandiri on corporate image through public. Convenience sampling method has been selected in order to obtain the data in this study. The analysis method that used was the path analysis. The research result had shown that: marketing public relation and service quality have significant influence simultaneously and partially on public opinion on the first structure equation. The second structure equation shows that: marketing public relation, service quality had significant influence simultaneously on corporate image. The service quality have not partially the quality of service have not influence significant partially on corporate, but variable marketing and public relation have  partially influential public opinion influence significant partially on corporate image.DOI: 10.15408/etk.v12i2.1916

  2. Focus on Ethics and Public Relations Practice in a University Classroom

    Science.gov (United States)

    Smudde, Peter M.

    2011-01-01

    Public relations action relies on sound decision making about how to inspire cooperation between an organization and its publics. Such thinking must uphold principles for ethical communication. Effectively combining ethics with public relations practice for students is key. A pedagogical approach to public relations ethics, hinging on selected…

  3. Angiogenesis inhibitors in the treatment of prostate cancer

    Directory of Open Access Journals (Sweden)

    Heath Elisabeth I

    2010-08-01

    Full Text Available Abstract Prostate cancer remains a significant public health problem, with limited therapeutic options in the setting of castrate-resistant metastatic disease. Angiogenesis inhibition is a relatively novel antineoplastic approach, which targets the reliance of tumor growth on the formation of new blood vessels. This strategy has been used successfully in other solid tumor types, with the FDA approval of anti-angiogenic agents in breast, lung, colon, brain, and kidney cancer. The application of anti-angiogenic therapy to prostate cancer is reviewed in this article, with attention to efficacy and toxicity results from several classes of anti-angiogenic agents. Ultimately, the fate of anti-angiogenic agents in prostate cancer rests on the eagerly anticipated results of several key phase III studies.

  4. Tumour Angiogenesis: A Growth Area—From John Hunter to Judah Folkman and Beyond

    Directory of Open Access Journals (Sweden)

    J. A. Stephenson

    2013-01-01

    Full Text Available Angiogenesis is the growth of new blood vessels in the body. Abnormal angiogenesis is recognised as a “common denominator” in many disease processes, and the development of angiogenesis inhibitors holds great hope in the ongoing battle against cancer. The field of angiogenesis has roots in the Hunterian era of the late eighteenth century but did not begin to blossom until the early 1970s when the then controversial findings and conclusions of Judah Folkman, the “father of angiogenesis,” were first published. There were only 65 publications with angiogenesis in the title in the 10 years after Folkman first proposed the idea of tumour angiogenesis, compared to over 9,000 publications from the year 2000 to 2010. In this review we will explore the voyage of discovery from the first observations of John Hunter in the eighteenth century, via the struggle faced by Folkman to prove the importance of angiogenesis, and finally how his determination has led to modern angiogenesis inhibitors being used in everyday clinical practice.

  5. 77 FR 1689 - Public Availability of Federal Labor Relations Authority FY 2011 Service Contract Inventory

    Science.gov (United States)

    2012-01-11

    ... From the Federal Register Online via the Government Publishing Office FEDERAL LABOR RELATIONS AUTHORITY Public Availability of Federal Labor Relations Authority FY 2011 Service Contract Inventory AGENCY: Federal Labor Relations Authority. ACTION: Notice of Public Availability of FY 2011 Service...

  6. 76 FR 40937 - Public Availability of National Labor Relations Board's FY 2010 Service Contract Inventory

    Science.gov (United States)

    2011-07-12

    ... From the Federal Register Online via the Government Publishing Office NATIONAL LABOR RELATIONS BOARD Public Availability of National Labor Relations Board's FY 2010 Service Contract Inventory AGENCY: National Labor Relations Board. ACTION: Notice of public availability of FY 2010 Service...

  7. 77 FR 5062 - Public Availability of National Labor Relations Board's FY 2011 Service Contract Inventory

    Science.gov (United States)

    2012-02-01

    ... From the Federal Register Online via the Government Publishing Office NATIONAL LABOR RELATIONS BOARD Public Availability of National Labor Relations Board's FY 2011 Service Contract Inventory AGENCY: National Labor Relations Board. ACTION: Notice of public availability of FY 2011 Service...

  8. 76 FR 26296 - Public Availability of Federal Labor Relations Authority FY 2010 Service Contract Inventory

    Science.gov (United States)

    2011-05-06

    ... From the Federal Register Online via the Government Publishing Office FEDERAL LABOR RELATIONS AUTHORITY Public Availability of Federal Labor Relations Authority FY 2010 Service Contract Inventory AGENCY: Federal Labor Relations Authority. ACTION: Notice of Public Availability of FY 2010 Service...

  9. The effects of communication techniques on public relation activities: A sample of hospitality business

    OpenAIRE

    Şirvan Şen Demir

    2011-01-01

    Nowadays, firms who give importance to public relations have been increasing rapidly in numbers. All modern firms either found public relations department in their body to deal with public relations operations or outsource this activity to consultants in order to communicate with target populations. Among the firms in tourism sector, hospitality companies are the ones that use public relations the most. The purpose of this study is to investigate the communication techniques in public relatio...

  10. Public Relations Research is Not as New as Some Think”: An Historical Perspective on the Evolution of Public Relations Measurement and Evaluation Practice

    OpenAIRE

    Watson, Tom

    2012-01-01

    Scott Cutlip’s ironic comment about the Publicity Bureau of Boston’s “The Barometer” media analysis card index of 1905-6 was that “public relations research is not as new as some think” (Cutlip, 1994, p. 21). It sets the scene for this investigation of the history of public relations measurement and evaluation. Cutlip identified that systematic measurement of public relations activity, which was practiced as press agentry and publicity, could be evidenced in the first decade of the twentieth ...

  11. Molecular targeting of angiogenesis for imaging and therapy

    Energy Technology Data Exchange (ETDEWEB)

    Brack, Simon S.; Neri, Dario [Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology Zurich (Switzerland); Dinkelborg, Ludger M. [Research Laboratories of Schering AG, Berlin (Germany)

    2004-09-01

    Angiogenesis, i.e. the proliferation of new blood vessels from pre-existing ones, is an underlying process in many human diseases, including cancer, blinding ocular disorders and rheumatoid arthritis. The ability to selectively target and interfere with neovascularisation would potentially be useful in the diagnosis and treatment of angiogenesis-related diseases. This review presents the authors' views on some of the most relevant markers of angiogenesis described to date, as well as on specific ligands which have been characterised in pre-clinical animal models and/or clinical studies. Furthermore, we present an overview on technologies which are likely to have an impact on the way molecular targeting of angiogenesis is performed in the future. (orig.)

  12. Angiogenesis and Its Therapeutic Opportunities

    Directory of Open Access Journals (Sweden)

    So Young Yoo

    2013-01-01

    Full Text Available Angiogenesis plays critical roles in human physiology that range from reproduction and fetal growth to wound healing and tissue repair. The sophisticated multistep process is tightly regulated in a spatial and temporal manner by “on-off switch signals” between angiogenic factors, extracellular matrix components, and endothelial cells. Uncontrolled angiogenesis may lead to several angiogenic disorders, including vascular insufficiency (myocardial or critical limb ischemia and vascular overgrowth (hemangiomas, vascularized tumors, and retinopathies. Thus, numerous therapeutic opportunities can be envisaged through the successful understanding and subsequent manipulation of angiogenesis. Here, we review the clinical implications of angiogenesis and discuss pro- and antiangiogenic agents that offer potential therapy for cancer and other angiogenic diseases.

  13. Cerebral insulin, insulin signaling pathway, and brain angiogenesis.

    Science.gov (United States)

    Zeng, Yi; Zhang, Le; Hu, Zhiping

    2016-01-01

    Insulin performs unique non-metabolic functions within the brain. Broadly speaking, two major areas of these functions are those related to brain endothelial cells and the blood-brain barrier (BBB) function, and those related to behavioral effects, like cognition in disease states (Alzheimer's disease, AD) and in health. Recent studies showed that both these functions are associated with brain angiogenesis. These findings raise interesting questions such as how they are linked to each other and whether modifying brain angiogenesis by targeting certain insulin signaling pathways could be an effective strategy to treat dementia as in AD, or even to help secure healthy longevity. The two canonical downstream pathways involved in mediating the insulin signaling pathway, the phosphoinositide-3 kinase (PI3K), and mitogen-activated protein kinase (MAPK) cascades, in the brain are supposed to be similar to those in the periphery. PI3K and MAPK pathways play important roles in angiogenesis. Both are involved in stimulating hypoxia inducible factor (HIF) in angiogenesis and could be activated by the insulin signaling pathway. This suggests that PI3K and MAPK pathways might act as cross-talk between the insulin signaling pathway and the angiogenesis pathway in brain. But the cerebral insulin, insulin signaling pathway, and the detailed mechanism in the connection of insulin signaling pathway, brain angiogenesis pathway, and healthy aging or dementias are still mostly not clear and need further studies.

  14. Angiogenesis and antiangiogenic agents in cervical cancer

    Directory of Open Access Journals (Sweden)

    Tomao F

    2014-12-01

    Full Text Available Federica Tomao,1 Anselmo Papa,2 Luigi Rossi,2 Eleonora Zaccarelli,2 Davide Caruso,2 Federica Zoratto,2 Pierluigi Benedetti Panici,1 Silverio Tomao2 1Department of Gynecology and Obstetrics, Sapienza University of Rome, Policlinico Umberto I, Rome, 2Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Oncology Unit, ICOT, Latina, Italy Abstract: Standard treatment of cervical cancer (CC consists of surgery in the early stages and of chemoradiation in locally advanced disease. Metastatic CC has a poor prognosis and is usually treated with palliative platinum-based chemotherapy. Current chemotherapeutic regimens are associated with significant adverse effects and only limited activity, making identification of active and tolerable novel targeted agents a high priority. Angiogenesis is a complex process that plays a crucial role in the development of many types of cancer. The dominant role of angiogenesis in CC seems to be directly related to human papillomavirus-related inhibition of p53 and stabilization of hypoxia-inducible factor-1α. Both of these mechanisms are able to increase expression of vascular endothelial growth factor (VEGF. Activation of VEGF promotes endothelial cell proliferation and migration, favoring formation of new blood vessels and increasing permeability of existing blood vessels. Since bevacizumab, a recombinant humanized monoclonal antibody binding to all isoforms of VEGF, has been demonstrated to significantly improve survival in gynecologic cancer, some recent clinical research has explored the possibility of using novel therapies directed toward inhibition of angiogenesis in CC too. Here we review the main results from studies concerning the use of antiangiogenic drugs that are being investigated for the treatment of CC. Keywords: cervical cancer, angiogenesis, human papillomavirus, bevacizumab, target therapies

  15. Angiogenesis in female reproductive system

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@Neovascularization, i.e. new blood vessels formation, can be divided into two different processes: vasculogenesis, whereby a primitive vascular network is established during embryogenesis from multipotential mesenchymal progenitors; and angiogenesis, which refers to the new blood vessels formation from pre-existing vessels[1,2]. Angiogenesis contributes to the most process throughout the whole life span from embryonic development to adult growth[2]. In this meaning, neovascularization is usually used to imply angiogenesis. Under physiological condi-tions, angiogenesis is a strictly regulated event and rarely happens in most adult tissues except for fracture or heal-ing of wounds[2,3]. However, a notable phenomenon is that the tissues of ovary and uterine endometrium are unique in the cycle-specific changes in vascularity that occur in each estrous/menstrual cycle. Active angiogenesis occurs in placenta to satisfy the needs of embryonic implantation and development. Defects in angiogenesis are associated with some gynecopathies including luteal phase defect, endometriosis, pregnancy loss and preeclampsia[4].

  16. Putting the "Public" First in Public Relations: An Exploratory Study of Municipal Employee Public Service Attitudes, Job Satisfaction and Communication Variables.

    Science.gov (United States)

    Jeffers, Dennis W.

    A study was conducted to determine (1) which actions municipal employees consider important to a city's overall public relations effort, (2) the attitudes of city employees toward public service activities, (3) the relationship between attitude and job satisfaction, and (4) ways to improve employee attitudes and, perhaps, public service…

  17. Angiogenesis in male breast cancer

    Directory of Open Access Journals (Sweden)

    Kanthan Rani

    2005-03-01

    Full Text Available Abstract Background Male breast cancer is a rare but aggressive and devastating disease. This disease presents at a later stage and in a more advanced fashion than its female counterpart. The immunophenotype also appears to be distinct when compared to female breast cancer. Angiogenesis plays a permissive role in the development of a solid tumor and provides an avenue for nutrient exchange and waste removal. Recent scrutiny of angiogenesis in female breast cancer has shown it to be of significant prognostic value. It was hypothesized that this holds true in invasive ductal carcinoma of the male breast. In the context of male breast cancer, we investigated the relationship of survival and other clinico-pathological variables to the microvascular density of the tumor tissue. Methods Seventy-five cases of primary male breast cancer were identified using the records of the Saskatchewan Cancer Agency over a period of 26 years. Forty-seven cases of invasive ductal carcinoma of the male breast had formalin-fixed paraffin-embedded tissue blocks that were suitable for this study. All cases were reviewed. Immunohistochemical staining was performed for the angiogenic markers (cluster designations 31 (CD31, 34 (CD34 and 105 (CD105, von Willebrand factor (VWF, and vascular endothelial growth factor (VEGF. Microvascular density (MVD was determined using average, centre, and highest microvessel counts (AMC, CMC, and HMC, respectively. Statistical analyses compared differences in the distribution of survival times and times to relapse between levels of MVD, tumor size, node status and age at diagnosis. In addition, MVD values were compared within each marker, between each marker, and were also compared to clinico-pathological data. Results Advanced age and tumor size were related to shorter survival times. There were no statistically significant differences in distributions of survival times and times to relapse between levels of MVD variables. There was no

  18. Danish Public Diplomacy - A dialogic approach to international relations between states and publics

    OpenAIRE

    Meiner-Jensen,Nicklas

    2012-01-01

    This study deals with the approach to Public Diplomacy in the Danish Foreign Ministry. Public Diplomacy is the international communication between a state and a foreign public that aims to promote the state, its policies and the relationship between the sender and the receiver. The study takes a dialogic approach to the concept that focuses on dialogue, symmetry and credibility. It is the conclusion of the study that a more reciprocal approach to Public Diplomacy is beneficial to the sender-s...

  19. Statins and angiogenesis: Is it about connections?

    Energy Technology Data Exchange (ETDEWEB)

    Khaidakov, Magomed, E-mail: mkhaidakov@uams.edu [Division of Cardiology, University of Arkansas for Medical Sciences and VA Medical Center, Little Rock, AR (United States); Wang, Wenze [Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR (United States); Khan, Junaid A.; Kang, Bum-Yong; Hermonat, Paul L. [Division of Cardiology, University of Arkansas for Medical Sciences and VA Medical Center, Little Rock, AR (United States); Mehta, Jawahar L., E-mail: Mehtajl@uams.edu [Division of Cardiology, University of Arkansas for Medical Sciences and VA Medical Center, Little Rock, AR (United States)

    2009-09-25

    Statins, inhibitors of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, have been shown to induce both angiogenic and angiostatic responses. We attempted to resolve this controversy by studying the effects of two different statins, rosuvastatin and simvastatin, in two different assay systems. In the matrigel angiogenesis assay, both statins enhanced tube formation by human umbilical vein endothelial cells (HUVECs, p < 0.01 vs. control). In the ex vivo mouse aortic ring sprouting assay, both statins virtually abolished new vessel formation (p < 0.01). As a basic difference between the two models of angiogenesis is dispersed state of endothelial cells vs. compact monolayer, we analyzed influence of statins on endothelial junction proteins. RT-PCR analysis and cytoimmunostaining of HUVECs treated with simvastatin revealed increased expression of VE-cadherin (p < 0.05). The blockade of VE-cadherin with a specific antibody reversed simvastatin-induced tube formation (p < 0.002). These data suggest that statins through VE-cadherin stimulation modulate cell-cell adhesion and diminish the ability of cells to proliferate and migrate. The observations of reduced angiogenesis in the intact vessel may relate to anti-atherosclerotic and anti-cancer effects of statins, and provide a feasible explanation for conflicting data under different experimental conditions.

  20. Molecular Therapeutic Targets for Glioma Angiogenesis

    Directory of Open Access Journals (Sweden)

    Shingo Takano

    2010-01-01

    Full Text Available Due to the prominent angiogenesis that occurs in malignant glioma, antiangiogenic therapy has been attempted. There have been several molecular targets that are specific to malignant gliomas, as well as more broadly in systemic cancers. In this review, I will focus on some topics related to molecular therapeutic targets for glioma angiogenesis. First, important angiogenic factors that could be considered molecular targets are VEGF, VEGF-induced proteins on endothelial cells, tissue factor, osteopontin, v3 integrin, and thymidine phosphorylase as well as endogenous inhibitors, soluble Flt1, and thrombospondin 1. Second, hypoxic areas are also decreased by metronomic CPT11 treatment as well as temozolomide. Third, glioma-derived endothelial cells that are genetically and functionally distinct from normal endothelial cells should be targeted, for example, with SDF-1 and CXCR7 chemokine. Fourth, endothelial progenitor cells (EPCs likely contribute towards glioma angiogenesis in the brain and could be useful as a drug delivery tool. Finally, blockade of delta-like 4 (Dll4 results in a nonfunctioning vasculature and could be another important target distinct from VEGF.

  1. Toll-Like Receptors in Angiogenesis

    Directory of Open Access Journals (Sweden)

    Karsten Grote

    2011-01-01

    Full Text Available Toll-like receptors (TLRs are known as pattern-recognition receptors related to the Toll protein of Drosophila. After recognition of pathogen-associated molecular patterns of microbial origin, the TLRs alert the immune system, and initiate innate and adaptive immune responses. The TLR system, though, is not confined solely to the leukocyte-mediated immune defense against exogenous pathogens. Besides myeloid cells, TLR expression has been reported in multiple tissues and cell types, including epithelial and endothelial cells. Moreover, despite the microbial patterns that are commonly accepted as TLR ligands, there is increasing evidence that TLRs also recognize host-derived molecules. In this regard, recent studies point to an involvement of TLRs in various chronic inflammatory disorders and cardiovascular diseases, including atherosclerosis, rheumatoid arthritis, systemic lupus erythematosus, and even cancer. A common feature of these disorders is an enhanced so-called inflammation-induced angiogenesis. However, inflammation-induced angiogenesis is not solely a key component of pathogen defense during acute infection or chronic inflammatory disorders, but also plays a critical role in repair mechanisms, e.g., wound healing and subsequent tissue regeneration. Interestingly, the latest research could coincidentally demonstrate that TLR activation promotes angiogenesis in various inflammatory settings in response to both exogenous and endogenous ligands, although the precise mode of action of TLRs in this context still remains ambiguous. The objective of this review is to present evidence for the implication of TLRs in angiogenesis during physiological and pathophysiological processes, and the potential clinical relevance for new treatment regimes involving TLR modulation.

  2. Hypoxia,angiogenesis and liver fibrogenesis in the progression of chronic liver diseases

    Institute of Scientific and Technical Information of China (English)

    Claudia; Paternostro; Ezio; David; Erica; Novo; Maurizio; Parola

    2010-01-01

    Angiogenesis is a dynamic,hypoxia-stimulated and growth factor-dependent process,and is currently referred to as the formation of new vessels from preexisting blood vessels.Experimental and clinical studies have unequivocally reported that hepatic angiogenesis,irrespective of aetiology,occurs in conditions of chronic liver diseases(CLDs) characterized by perpetuation of cell injury and death,inflammatory response and progressive fibrogenesis.Angiogenesis and related changes in liver vascular architecture,th...

  3. Analyzing Student Perceptions of Two Measures of Diversity in a Public Relations Class.

    Science.gov (United States)

    Detweiler, John S.; Hammond, Frankie A.

    A study analyzed the effects of instruction in an introduction to public relations class on student perceptions of contrasting public relations communication styles. Two standard models, the traditional scales of family communication patterns and J. E. Grunig's triangular model of public relations objectives, were adapted for the study. A content…

  4. Advertising and Public Relations in Transition from Communism: The Case of Hungary, 1989-1994.

    Science.gov (United States)

    Hiebert, Ray E.

    1994-01-01

    Discusses the gradual rise of free print media, Western-style advertising and marketing, and limited public relations in Hungary in its first four years of democracy (1990-94). Notes how Hungary's first democratically elected government failed to understand the public relations implications of a free press, made one public relations mistake after…

  5. Public Relations: The Route to Success and Influence. Public Relations for Your Library: A Tool for Effective Communications; Tooting Your Own Horn: Web-Based Public Relations for the School Media Specialist; Bookmarks as a Teaching Tool; Customers and Culture: The Who and What of Library Public Relations Efforts; Strategies for Successful Job Transition.

    Science.gov (United States)

    Lyon, Linda; Silverstein, Roberta; Fisher, Julieta Dias; Hill, Ann; Hegel, Claudette; Miller, Donna; Moyer, Mary

    2002-01-01

    This special section includes five articles that discuss public relations strategies for school librarians. Highlights include effective communication, including measuring and evaluating the success of public relations efforts; Web-based public relations; giving bookmarks to students; customers and cultural contexts; and successful job…

  6. Missing Citations, Bulking Biographies, and Unethical Collaboration: Types of Cheating among Public Relations Majors

    Science.gov (United States)

    Auger, Giselle A.

    2013-01-01

    Students cheat. For the field of public relations, which continually struggles for credibility, the issue of student cheating should be paramount, as the unethical students of today become tomorrow's practitioners. Through a survey of 170 public relations majors, this study examined the importance students place on the Public Relations Society of…

  7. Using "The West Wing" for Problem-Based Learning in Public Relations Courses

    Science.gov (United States)

    Smudde, Peter M.; Luecke, John R.

    2005-01-01

    Integrating "The West Wing" in public relations courses can effectively dramatize the concrete and abstract dimensions of public relations. In turn, students see public relations in action (albeit fictionally so) and learn much about it through structured lessons. From individual writing assignments about situations in "The West Wing," to the…

  8. 48 CFR 231.205-1 - Public relations and advertising costs.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Public relations and... PROCEDURES Contracts With Commercial Organizations 231.205-1 Public relations and advertising costs. (e) See... public relations and advertising costs also include monies paid to the Government associated with...

  9. At the Fundraising Core: Strategic Public Relations in Fundraising Practice. CASE White Paper

    Science.gov (United States)

    Satchwell, Carol M.

    2010-01-01

    This white paper reports on a study exploring the views of chief fundraising executives at private colleges and universities about the relationship between public relations and fundraising. The research focused on how fundraising executives define public relations and use public relations tactics and strategies within their institutions'…

  10. Professionalism in Public Relations Pedagogy: A Comparative Analysis of Public Relations Curricula among the United States, the United Kingdom, and South Korea

    Science.gov (United States)

    Chung, Wonjun; Choi, Jinbong

    2012-01-01

    Based on a concept of professionalism, this study analyzed and compared current public relations curricula of higher education among the United States, the United Kingdom, and South Korea. In terms of three educational orientations, results indicated that public relations education in the United States is the most balanced among theoretical,…

  11. Ginseng on Cancer: Potential Role in Modulating Inflammation-Mediated Angiogenesis.

    Science.gov (United States)

    Dai, Daisy; Zhang, Chun-Feng; Williams, Stephanie; Yuan, Chun-Su; Wang, Chong-Zhi

    2017-01-01

    Angiogenesis is a regulated process integral to many physiological and pathological situations, including carcinogenesis and tumor growth. The majority of the angiogenic processes are related to inflammation. The interplay is not only important in the case of pathogen entry but also influential in chronic inflammatory diseases, tumor growth and tissue regeneration. Modulating the interaction between inflammation and angiogenesis could be an important target for cancer treatment and wound healing alike. Ginseng has a wide range of pharmacological effects, including anti-inflammatory and angiogenesis-modulating activities. This paper presents the recent research progresses on the inhibition of angiogenesis by ginseng and its active constituents, with a particular focus on processes mediated by inflammation. The modulatory role of ginseng compounds in inflammation-mediated angiogenesis involving hypoxia and microRNAs are also discussed. With the potential to modulate the angiogenesis at the transcriptional, translational and protein signaling level via various different mechanisms, ginseng could prove to be effective in cancer therapeutics.

  12. PUBLIC RELATIONS IN PUBLIC ADMINISTRATION: ROLE AND MANAGEMENT, IN A SOCIO-POLITICAL MARKETING CONTEXT

    Directory of Open Access Journals (Sweden)

    Dorian Pocovnicu

    2014-07-01

    Full Text Available Many agree that PR and marketing are at their best when used together, when it comes to local public administration institutions there is the need for both an individual and symbiotic approach of the two. Taking into consideration that public interest organizations act within public space, PR represents a public communication strategy. Thus they present the role of generating a climate and state of social normality and, especially in democratic societies, PR plays the part of generator of communication flows between public institutions, citizens and stakeholders. In a social-political marketing context, envisaged as an aggregate of processes, with a multiple purpose, the generator which is PR must unfold coherently for each of the processes. It is our purpose in this paper to depict the PR role and management in the case of one local public administration institution (Bacau Prefect Institution, in a socio-political marketing context.

  13. The Necessity of Public Relations for Sustainable Mining Activities

    Science.gov (United States)

    Lee, Hyunbock; Ji, Sangwoo

    2015-04-01

    other hand, in the survey to determine what the greatest difficulties of the current mining activities, 54% of mining companies chose environmental regulations, 26% of mining companies chose conflicts between mine area residents and mining companies. Environmental regulations are may defined as the greatest difficulty of current mining activities. But most of environmental regulation's problems are caused by frictions with residents, because all of South Korean mines are very close to villages. So, the biggest difficulty of mining activities can be defined conflicts between residents and mining companies. Moreover, general people in South Korea including some mining engineers recognize the mining industry as a declined and pollution industry. Without clear understanding of mining activities, any mine developments and policies related to mining activities cannot be made by rational discussions. And, if their recognition is not formed in a rational way, it will be turned to extreme fear or blind hatred. Therefore, to understand mining activities correctly, the effective public relations strategy is necessary such as corporate advertisements or public advertisements.

  14. Comparison of three rapamycin dosing schedules in A/J Tsc2+/- mice and improved survival with angiogenesis inhibitor or asparaginase treatment in mice with subcutaneous tuberous sclerosis related tumors

    Directory of Open Access Journals (Sweden)

    Dabora Sandra L

    2010-02-01

    Full Text Available Abstract Background Tuberous Sclerosis Complex (TSC is an autosomal dominant tumor disorder characterized by the growth of hamartomas in various organs including the kidney, brain, skin, lungs, and heart. Rapamycin has been shown to reduce the size of kidney angiomyolipomas associated with TSC; however, tumor regression is incomplete and kidney angiomyolipomas regrow after cessation of treatment. Mouse models of TSC2 related tumors are useful for evaluating new approaches to drug therapy for TSC. Methods In cohorts of Tsc2+/- mice, we compared kidney cystadenoma severity in A/J and C57BL/6 mouse strains at both 9 and 12 months of age. We also investigated age related kidney tumor progression and compared three different rapamycin treatment schedules in cohorts of A/J Tsc2+/- mice. In addition, we used nude mice bearing Tsc2-/- subcutaneous tumors to evaluate the therapeutic utility of sunitinib, bevacizumab, vincristine, and asparaginase. Results TSC related kidney disease severity is 5-10 fold higher in A/J Tsc2+/- mice compared with C57BL/6 Tsc2+/- mice. Similar to kidney angiomyolipomas associated with TSC, the severity of kidney cystadenomas increases with age in A/J Tsc2+/- mice. When rapamycin dosing schedules were compared in A/J Tsc2+/- cohorts, we observed a 66% reduction in kidney tumor burden in mice treated daily for 4 weeks, an 82% reduction in mice treated daily for 4 weeks followed by weekly for 8 weeks, and an 81% reduction in mice treated weekly for 12 weeks. In the Tsc2-/- subcutaneous tumor mouse model, vincristine is not effective, but angiogenesis inhibitors (sunitinib and bevacizumab and asparaginase are effective as single agents. However, these drugs are not as effective as rapamycin in that they increased median survival only by 24-27%, while rapamycin increased median survival by 173%. Conclusions Our results indicate that the A/J Tsc2+/- mouse model is an improved, higher through-put mouse model for future TSC

  15. Angiogenesis in the corpus luteum

    Directory of Open Access Journals (Sweden)

    Wulff Christine

    2003-11-01

    Full Text Available Abstract The corpus luteum (CL is a site of intense angiogenesis. Within a short period, this is followed either by controlled regression of the microvascular tree in the non-fertile cycle, or maintenance and stabilisation of the new vasculature a conceptual cycle. The molecular regulation of these diverse aspects is examined. The CL provides a unique model system in which to study the cellular and molecular regulation of angiogenesis. Vascular endothelial growth factor (VEGF has been found to have a major role in the CL. By targeting its action at specific stages of the luteal phase in vivo by antagonists, profound inhibitory effects on luteal angiogenesis and function are observed.

  16. Agency relations and managed performance in public universities in Uganda

    Directory of Open Access Journals (Sweden)

    James R.K. Kagaari

    2013-01-01

    Full Text Available Orientation: This article focused on the need for improved employer-employee relationships in order for public universities in Uganda to achieve their intended objectives.Research purpose: The purpose of this article was to review the need for appropriate employer-employee relationships that will ensure quality services and service delivery in public universities in Uganda.Motivation for the study: The researchers set out to examine why managers of public universities in Uganda were continuously paying less attention to the needs of the employees.Research design, approach and method: A descriptive research design was employed and 12 respondents, purposively selected from 4 public universities, were interviewed. Data were recorded, transcribed and analysed using Nvivo software. This article is based on the perspective of agency theory, and discussed the contractual relationship between management and employees. The agency theory was deemed necessary because of its contribution to organisational literature.Main findings: There is a need to create and nurture a collegial working climate that promotes quality interactions through information sharing. This results in creating and retaining motivated and committed employees, and also helps to overcome the paradox of balancing the high demand for university education whilst offering quality services.Practical/managerial implications: Managers have to continuously monitor and accommodate employee needs and demands.Contribution/value-add: The potential value of the paper is its function as a guide for public universities to have visionary managers that will introduce new approaches to managing public universities in a competitive global environment.

  17. 76 FR 62092 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2011-10-06

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... Thereof, and Related Software, DN 2846; the Commission is soliciting comments on any public interest... complainant, proposed respondents, other interested parties, and members of the public are invited to...

  18. 76 FR 19126 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2011-04-06

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... Containing Same, and Related Methods, DN 2798; the Commission is soliciting comments on any public interest..., other interested parties, and members of the public are invited to file comments, not to exceed...

  19. Is using social media "good" for the public relations profession? A critical reflection

    DEFF Research Database (Denmark)

    Valentini, Chiara

    2015-01-01

    Scholarship in public relations seems to be overly positive about social media. The dominant discourse in public relations is that using social media is “good”, because social media can help organizations in developing dialogs and relationships with publics and in engaging with them. Yet empirical...

  20. Publicity as policy: the changing role of press and public relations at the BMA, 1940s-80s.

    Science.gov (United States)

    Loughlin, Kelly

    2005-01-01

    Relationships between policy and publicity or public relations (PR) have been questioned since the emergence of professional public relations in the early-twentieth century. In the field of health and medicine organised PR activity began to flourish in the decades following World War Two. Its presence became evident in government departments, in professional associations, voluntary bodies and campaigning groups. Increasingly, policy decisions had to be publicly performed through rituals like the press conference. This chapter documents the development of press and PR activity at the British Medical Association (BMA) from the 1950s to the 1980s. The BMA provides a well-documented case, which can be used to suggest broader shifts in the association between policy and publicity.

  1. A bibliography of IRIS-related publications, 2000-2011

    Science.gov (United States)

    Muco, B.

    2012-12-01

    Citations and acknowledgements in scientific journals can be an indicator of the role an organization has on the research of that field. Since its formation and incorporation in May 1984, the IRIS Consortium (Incorporated Research Institutions for Seismology) is mentioned more and more as a valuable source of data, instruments and programs in the literature of earth sciences. As a large organization with more than 100 member domestic institutes and about 40 international affiliates, obviously IRIS has a direct impact on the earth sciences through all its programs, projects, workshops, symposia, and news¬letters and as a lively forum for exchanging ideas. In order to maintain support from National Science Foundation (NSF) and the research community, it is important to document the continued use of IRIS facilities in basic research programs. IRIS maintains a database of articles that are based on the use of IRIS facilities or which reference use of IRIS data and resources. Articles in this database have been either been provided to IRIS by the authors or selected through an annual search of a number of prominent journals. A text version of the full bibliographic database is available on the IRIS website and a version in EndNote format is also provided. To provide a more complete bibliography and a consistent evaluation of temporal tends in publications, a special annual search began in 2000 which focused on a subset of key seismology and Earth science journals: Bulletin of Seismological Society of America, Journal of Geophysical Research, Seismological Research Letters, Geophysical Research Letters, Earth and Planetary Science Letters, Physics of the Earth and Planetary Interiors, Tectonophysics, Geophysical Journal International, Nature, Science, Geology and EOS. Using different search engines as Scirus, ScienceDirect, GeoRef, OCLC First Search, EASI Search, NASA Abstract Service etc. for online journals and publishers' databases, we searched for key words (IRIS

  2. Social Media, Traditional Media and Marketing Communication of Public Relations:A Study of Banking Industry

    OpenAIRE

    Khajeheian, Datis; Mirahmadi, Fereshteh

    2015-01-01

    Public relations are undertaking more important role in the marketing communication and advertising. The present paper reports a survey conducted in three Iranian banks’ public relations departments to understand how they use different media in their marketing communications and other related functions. A classification of public relations functions including fourteen functions in three categories has taken as research framework and by using a questionnaire, eight media have been asked to ran...

  3. Ethical practice of social media in public relations

    CERN Document Server

    DiStaso, Marcia W

    2014-01-01

    Given the high rate of social media use by the public, organizations are compelled to engage with key audiences through these outlets. Social media engagement requires organizations to actively participate with public groups, and this highly-interactive exchange raises a new set of ethical concerns for communicators. In this rapidly changing communications environment, the long-term implications of social media are uncertain, and this book provides the much needed research to understand its impact on audiences and organizations.Through an examination of a broad range of ethics concepts includi

  4. Do Public Relations and Journalism’s Converging Roles Affect How They Perceive Each Other?

    DEFF Research Database (Denmark)

    Valentini, Chiara

    2014-01-01

    Media relations is historically a core activity qualifying public relations from other communication-related professions and is widely practiced in many organizations. Despite the increasing use of digital media to directly communicate with publics, journalists are still key stakeholders...... for organizations. Also communications by organizations have become more and more mediatized and at the same time more and more journalists are switching to a public relations career. Yet, if more journalists are becoming public relations practitioners and more public relations practitioners are adopting...... journalistic working practices, does this change the way these communicators perceive themselves and the other profession? The aim of this study is to provide some insights from a southern, Latin country, Italy, on how Italian public relations practitioners and journalists perceive their and the other...

  5. Changing Governance and Authority Relations in the Public Sciences

    Science.gov (United States)

    Whitley, Richard

    2011-01-01

    Major changes in the governance of higher education and the public sciences have taken place over the past 40 or so years in many OECD countries. These have affected the nature of authority relationships governing research priorities and the evaluation of results. In particular, the increasing exogeneity, formalisation and substantive nature of…

  6. Public Relations Opportunities for Schools Utilizing Innovations in Virtual Communities

    Science.gov (United States)

    O'Reilly, Frances L.; Matt, John J.

    2013-01-01

    With the dawn of the Information Age, schools, along with other organizations, must take note of the varied ways individuals and groups in society are communicating. Today, with the many forms of communication, most information is made public in real time. In a qualitative national study in the United States, respondents identified positive and…

  7. Folate Deficiency Could Restrain Decidual Angiogenesis in Pregnant Mice.

    Science.gov (United States)

    Li, Yanli; Gao, Rufei; Liu, Xueqing; Chen, Xuemei; Liao, Xinggui; Geng, Yanqing; Ding, Yubin; Wang, Yingxiong; He, Junlin

    2015-08-04

    The mechanism of birth defects induced by folate deficiency was focused on mainly in fetal development. Little is known about the effect of folate deficiency on the maternal uterus, especially on decidual angiogenesis after implantation which establishes vessel networks to support embryo development. The aim of this study was to investigate the effects of folate deficiency on decidual angiogenesis. Serum folate levels were measured by electrochemiluminescence. The status of decidual angiogenesis was examined by cluster designation 34 (CD34) immunohistochemistry and the expression of angiogenic factors, including vascular endothelial growth factor A (VEGFA), placental growth factor (PLGF), and VEGF receptor 2 (VEGFR2) were also tested. Serum levels of homocysteine (Hcy), follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), progesterone (P4), and estradiol (E2) were detected by Enzyme-linked immunosorbent assay. The folate-deficient mice had a lower folate level and a higher Hcy level. Folate deficiency restrained decidual angiogenesis with significant abnormalities in vascular density and the enlargement and elongation of the vascular sinus. It also showed a reduction in the expressions of VEGFA, VEGFR2, and PLGF. In addition, the serum levels of P4, E2, LH, and PRL were reduced in folate-deficient mice, and the expression of progesterone receptor (PR) and estrogen receptor α (ERα) were abnormal. These results indicated that folate deficiency could impaire decidual angiogenesis and it may be related to the vasculotoxic properties of Hcy and the imbalance of the reproductive hormone.

  8. Folate Deficiency Could Restrain Decidual Angiogenesis in Pregnant Mice

    Directory of Open Access Journals (Sweden)

    Yanli Li

    2015-08-01

    Full Text Available The mechanism of birth defects induced by folate deficiency was focused on mainly in fetal development. Little is known about the effect of folate deficiency on the maternal uterus, especially on decidual angiogenesis after implantation which establishes vessel networks to support embryo development. The aim of this study was to investigate the effects of folate deficiency on decidual angiogenesis. Serum folate levels were measured by electrochemiluminescence. The status of decidual angiogenesis was examined by cluster designation 34 (CD34 immunohistochemistry and the expression of angiogenic factors, including vascular endothelial growth factor A (VEGFA, placental growth factor (PLGF, and VEGF receptor 2 (VEGFR2 were also tested. Serum levels of homocysteine (Hcy, follicle stimulating hormone (FSH, luteinizing hormone (LH, prolactin (PRL, progesterone (P4, and estradiol (E2 were detected by Enzyme-linked immunosorbent assay. The folate-deficient mice had a lower folate level and a higher Hcy level. Folate deficiency restrained decidual angiogenesis with significant abnormalities in vascular density and the enlargement and elongation of the vascular sinus. It also showed a reduction in the expressions of VEGFA, VEGFR2, and PLGF. In addition, the serum levels of P4, E2, LH, and PRL were reduced in folate-deficient mice, and the expression of progesterone receptor (PR and estrogen receptor α (ERα were abnormal. These results indicated that folate deficiency could impaire decidual angiogenesis and it may be related to the vasculotoxic properties of Hcy and the imbalance of the reproductive hormone.

  9. Role of angiogenesis in the pathogenesis of oral lichen planus

    Directory of Open Access Journals (Sweden)

    Nitasha Mittal

    2012-01-01

    Full Text Available Background: The etiology of oral lichen planus (OLP is not fully understood. It is generally considered to be a T-cell mediated chronic inflammatory oral mucosal disease. There is increasing evidence that chronic inflammation is linked to the diseases associated with endothelial dysfunction and is involved in the induction of aberrant angiogenesis. Aim: Our aim was to evaluate the role of angiogenesis in the pathogenesis of OLP by immunohistochemistry, using the CD34 antibody. Materials and Methods: Forty tissue sections (7 of erosive lichen planus, 18 of reticular oral lichen planus, and 15 of normal oral mucosa, were assessed for microvessel density (MVD in five selected areas of high inflammatory infiltrate by immunohistochemistry for the expression of CD34 antibody. Results and Conclusion: The mean MVD was 44.47 in the control group (normal oral mucosa and 97.24 in the OLP group, showing that there is increased angiogenesis in the latter. Reticular OLP had mean MVD of 84.61 and erosive OLP had mean MVD of 129.71, showing relatively greater angiogenesis in erosive OLP as compared to reticular OLP. Thus, angiogenesis can be considered to play a role in both the etiopathogenesis and the progression of OLP.

  10. Oshkosh Logistic Management and Public Relations Responsibilities at NASA Langley

    Science.gov (United States)

    Beck, Danielle

    1995-01-01

    The central focus of my study for the summer of 1995 was to provide logistical support to Margaret Hunt, the logistics manager of the OSHKOSH airshow. In this capacity responsibilities included making arrangements for participants from NASA centers and SBIR companies for their stay in Wisconsin, while visiting the airshow, and managing staff for exhibits and the aerospace theater. A secondary purpose was to serve in other public service capacities by writing news releases, fact sheets, announcements, and articles for the Researcher News.

  11. 48 CFR 31.205-1 - Public relations and advertising costs.

    Science.gov (United States)

    2010-10-01

    ... advertising costs. 31.205-1 Section 31.205-1 Federal Acquisition Regulations System FEDERAL ACQUISITION... Organizations 31.205-1 Public relations and advertising costs. (a) Public relations means all functions and... such as advertising, customer relations, etc. (b) Advertising means the use of media to promote...

  12. Review of Selected Dissertations Relevant to the "Journal of School Public Relations"

    Science.gov (United States)

    Hurtado, DeAnn; McCue, Lesley

    2012-01-01

    The article provides summaries of doctoral dissertations completed between January 2008 and December 2011 addressing foci of the "Journal of School Public Relations". The five areas are public relations, communication, school and community relations, conflict management, and human resources management. The periodic summaries of these dissertations…

  13. Cultural influences on doing qualitative research in public relations in Mexico

    OpenAIRE

    Daymon, Christine; Hodges, Caroline E.M.

    2008-01-01

    Over the last decade in international public relations scholarship, there has been a significant growth in comparative research, offering illumination on the different practices, assumptions and expectations of those involved in public relations in both global and local contexts. The qualitative voice is increasingly heard because of its more nuanced insights on cultural difference. Yet there are significant challenges for researchers seeking to investigate public relations in cultures differ...

  14. Outcomes-based guidelines for the curriculation of Technikon level public relations education in South Africa.

    OpenAIRE

    2008-01-01

    The International Public Relations Association (IPRA) in their Gold Paper No.7 (1990:6) recognises two schools of thought about education and training for public relations : one that it is preparation for a technician level post and the other that it is preparation for management. These two approaches broadly represent that of public relations education in the USA and that in Europe, respectively. These two different approaches differ markedly. South African tertiary education utilises both o...

  15. The evolution of evaluation – the accelerating march towards the measurement of public relations effectiveness

    OpenAIRE

    Watson, Tom

    2011-01-01

    The measurement and evaluation of public relations effectiveness has long been a major professional and research issue (White and Blamphin 1994; Synnott and McKie 1997). Recently Watson (2008) found that it still ranked third in an international study of public relations research priorities. \\ud In the first half of the last century, there was little reference to it. The first major scholarly reference came in Cutlip and Center’s first edition of Effective Public Relations (1952) which implie...

  16. Public relations Svazu obchodu a cestovního ruchu ČR

    OpenAIRE

    Dragonová, Kateřina

    2012-01-01

    The purpose of the thesis is to analyze and evaluate strategy of public relations of the Czech Confederation of Commerce and Tourism. The theoretical part defines marketing communication in the marketing mix, brings the theoretical bases of public relations with the main focus on public relations in specific sectors. The practical part includes the overview of the Czech Confederation of Commerce and Tourism, the description of the PR tools and activities and evaluation of current PR strategy....

  17. Bidirectional regulation of angiogenesis by phytoestrogens through estrogen receptor-mediated signaling networks.

    Science.gov (United States)

    Liu, Hai-Xin; Wang, Yu; Lu, Qing; Yang, Ming-Zhu; Fan, Guan-Wei; Karas, Richard H; Gao, Xiu-Mei; Zhu, Yan

    2016-04-01

    Sex hormone estrogen is one of the most active intrinsic angiogenesis regulators; its therapeutic use has been limited due to its carcinogenic potential. Plant-derived phytoestrogens are attractive alternatives, but reports on their angiogenic activities often lack in-depth analysis and sometimes are controversial. Herein, we report a data-mining study with the existing literature, using IPA system to classify and characterize phytoestrogens based on their angiogenic properties and pharmacological consequences. We found that pro-angiogenic phytoestrogens functioned predominantly as cardiovascular protectors whereas anti-angiogenic phytoestrogens played a role in cancer prevention and therapy. This bidirectional regulation were shown to be target-selective and, for the most part, estrogen-receptor-dependent. The transactivation properties of ERα and ERβ by phytoestrogens were examined in the context of angiogenesis-related gene transcription. ERα and ERβ were shown to signal in opposite ways when complexed with the phytoestrogen for bidirectional regulation of angiogenesis. With ERα, phytoestrogen activated or inhibited transcription of some angiogenesis-related genes, resulting in the promotion of angiogenesis, whereas, with ERβ, phytoestrogen regulated transcription of angiogenesis-related genes, resulting in inhibition of angiogenesis. Therefore, the selectivity of phytoestrogen to ERα and ERβ may be critical in the balance of pro- or anti-angiogenesis process.

  18. New Exploration on Library Public Relation%图书馆公共关系新探

    Institute of Scientific and Technical Information of China (English)

    马玉英

    2012-01-01

    指出图书馆公共关系的重要性,对图书馆公共关系的概念及分类进行简要论述,提出图书馆公共关系的若干策略和需要注意的问题,阐述了危机公关的重要性。%The article points out the importance of public relation, makes brief discussion on the concept and classification of library public relation, puts forward some measures and problems of library public relation, and elaborates the importance of crisis public relation.

  19. 76 FR 383 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2011-01-04

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... 2777; the Commission is soliciting comments on any public interest issues raised by the complaint. FOR... any public interest issues raised by the complaint. Comments should address whether issuance of...

  20. 75 FR 53710 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2010-09-01

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... Marine Autopilots with GPS or IMU, DN 2752; the Commission is soliciting comments on any public interest... interested parties, and members of the public are invited to file comments, not to exceed five pages...

  1. 78 FR 7811 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2013-02-04

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... Canada. Proposed respondents, other interested parties, and members of the public are invited to file comments, not to exceed five (5) pages in length, inclusive of attachments, on any public interest...

  2. 77 FR 77091 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2012-12-31

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... Containing Same, DN 2925; the Commission is soliciting comments on any public interest issues raised by the... interested parties, and members of the public are invited to file comments, not to exceed five (5) pages...

  3. 76 FR 3924 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2011-01-21

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... public interest issues raised by the complaint. FOR FURTHER INFORMATION CONTACT: Marilyn R. Abbott... complainant, proposed respondents, other interested parties, and members of the public are invited to...

  4. 76 FR 11813 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2011-03-03

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... Devices, DN 2789; the Commission is soliciting comments on any public interest issues raised by the... public interest issues raised by the complaint. Comments should address whether issuance of an...

  5. 75 FR 48724 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2010-08-11

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... Components Thereof; DN 2747; the Commission is soliciting comments on any public interest issues raised by..., China. The complainant, proposed respondents, other interested parties, and members of the public...

  6. 78 FR 79708 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2013-12-31

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... Thereof, DN 2995; the Commission is soliciting comments on any public interest issues raised by the... respondents, other interested parties, and members of the public are invited to file comments, not to...

  7. 77 FR 59978 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2012-10-01

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... on any public interest issues raised by the complaint or complainant's filing under section 210.8(b.... Proposed respondents, other interested parties, and members of the public are invited to file comments,...

  8. 78 FR 77713 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2013-12-24

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... Phones and Tablets II, DN 2992; the Commission is soliciting comments on any public interest issues...). Proposed respondents, other interested parties, and members of the public are invited to file comments,...

  9. 78 FR 79479 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

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    2013-12-30

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... Integrated Circuits, DN 2994; the Commission is soliciting comments on any public interest issues raised by... 19 U.S.C. 1337(j). Proposed respondents, other interested parties, and members of the public...

  10. 77 FR 59003 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2012-09-25

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... Containing the Same, DN 2915 the Commission is soliciting comments on any public interest issues raised by..., inclusive of attachments, on any public interest issues raised by the complaint or section 210.8(b)...

  11. 76 FR 62842 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2011-10-11

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... Components Thereof, DN 2847; the Commission is soliciting comments on any public interest issues raised by... public interest issues raised by the complaint. Comments should address whether issuance of an...

  12. 75 FR 42783 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2010-07-22

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... and Components Thereof''; the Commission is soliciting comments on any public interest issues raised... any public interest issues raised by the complaint. Comments should address whether issuance of...

  13. 78 FR 60896 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2013-10-02

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... Containing Same, DN 2984; the Commission is soliciting comments on any public interest issues raised by the... cease and desist orders. Proposed respondents, other interested parties, and members of the public...

  14. 77 FR 72882 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2012-12-06

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... Commission is soliciting comments on any public interest issues raised by the complaint or complainant's... respondents, other interested parties, and members of the public are invited to file comments, not to...

  15. 75 FR 62140 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2010-10-07

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... Software, and Components Thereof, DN 2757; the Commission is soliciting comments on any public interest..., IL. The complainant, proposed respondents, other interested parties, and members of the public...

  16. 76 FR 18246 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2011-04-01

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... public interest issues raised by the complaint. FOR FURTHER INFORMATION CONTACT: James R. Holbein, Acting..., proposed respondents, other interested parties, and members of the public are invited to file comments,...

  17. 75 FR 57500 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2010-09-21

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... Components Thereof, DN 2755 ; the Commission is soliciting comments on any public interest issues raised by..., proposed respondents, other interested parties, and members of the public are invited to file comments,...

  18. 78 FR 64010 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2013-10-25

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... Thereof, DN 2987; the Commission is soliciting comments on any public interest issues raised by the... any public interest issues raised by the complaint or section 210.8(b) filing. Comments should...

  19. 76 FR 45294 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2011-07-28

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... Containing the Same, DN 2833; the Commission is soliciting comments on any public interest issues raised by... interested parties, and members of the public are invited to file comments, not to exceed five pages...

  20. 76 FR 39121 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2011-07-05

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... Products Containing the Same, DN 2823; the Commission is soliciting comments on any public interest issues... respondents, other interested parties, and members of the public are invited to file comments, not to...

  1. 75 FR 65652 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2010-10-26

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... public interest issues raised by the complaint. FOR FURTHER INFORMATION CONTACT: Marilyn R. Abbott..., telephone (202) 205-2000. The public version of the complaint can be accessed on the Commission's...

  2. 76 FR 18247 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2011-04-01

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U...; the Commission is soliciting comments on any public interest issues raised by the complaint. FOR... complainant, proposed respondents, other interested parties, and members of the public are invited to...

  3. 76 FR 797 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2011-01-06

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... Associated Systems, DN 2778; the Commission is soliciting comments on any public interest issues raised by.... The complainant, proposed respondents, other interested parties, and members of the public are...

  4. 76 FR 28456 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2011-05-17

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... Components Thereof, DN 2804; the Commission is soliciting comments on any public interest issues raised by... respondents, other interested parties, and members of the public are invited to file comments, not to...

  5. 76 FR 32987 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2011-06-07

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... and Products Containing Same, DN 2811; the Commission is soliciting comments on any public interest... respondents, other interested parties, and members of the public are invited to file comments, not to...

  6. 78 FR 76655 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2013-12-18

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... comments on any public interest issues raised by the complaint or complainant's filing under section 210.8... interested parties, and members of the public are invited to file comments, not to exceed five (5) pages...

  7. 76 FR 36936 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2011-06-23

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... 2821; the Commission is soliciting comments on any public interest issues raised by the complaint. FOR... interested parties, and members of the public are invited to file comments, not to exceed five pages...

  8. 78 FR 5495 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2013-01-25

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... Components Thereof, DN 2933; the Commission is soliciting comments on any public interest issues raised by.... Proposed respondents, other interested parties, and members of the public are invited to file comments,...

  9. 75 FR 66790 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2010-10-29

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... comments on any public interest issues raised by the complaint. FOR FURTHER INFORMATION CONTACT: Marilyn R... interested parties, and members of the public are invited to file comments, not to exceed five pages...

  10. 77 FR 7602 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2012-02-13

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... Haptics, DN 2875; the Commission is soliciting comments on any public interest issues raised by the... Holdings, Inc. of IL. Proposed respondents, other interested parties, and members of the public are...

  11. 75 FR 53981 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2010-09-02

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... comments on any public interest issues raised by the complaint. FOR FURTHER INFORMATION CONTACT: Marilyn R... respondents, other interested parties, and members of the public are invited to file comments, not to...

  12. 76 FR 29264 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2011-05-20

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... public interest issues raised by the complaint. FOR FURTHER INFORMATION CONTACT: James R. Holbein... interested parties, and members of the public are invited to file comments, not to exceed five pages...

  13. 77 FR 29689 - Receipt of Amended Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2012-05-18

    ... COMMISSION Receipt of Amended Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U.S... and Devices Containing Same, DN 2877; the Commission is soliciting comments on any public interest... Corporation of Taiwan. Proposed respondents, other interested parties, and members of the public are...

  14. 76 FR 51395 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2011-08-18

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... public interest issues raised by the complaint. FOR FURTHER INFORMATION CONTACT: James R. Holbein... respondents, other interested parties, and members of the public are invited to file comments, not to...

  15. 76 FR 35238 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2011-06-16

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... Products Containing Same, DN 2816; the Commission is soliciting comments on any public interest issues...-2000. The public version of the complaint can be accessed on the Commission's electronic docket...

  16. 76 FR 50756 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2011-08-16

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... comments on any public interest issues raised by the complaint. FOR FURTHER INFORMATION CONTACT: James R... complainant, proposed respondents, other interested parties, and members of the public are invited to...

  17. 76 FR 34100 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2011-06-10

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U..., other interested parties, and members of the public are invited to file comments, not to exceed five pages in length, on any public interest issues raised by the complaint. Comments should address...

  18. 76 FR 35014 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2011-06-15

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... any public interest issues raised by the complaint. FOR FURTHER INFORMATION CONTACT: James R. Holbein..., proposed respondents, other interested parties, and members of the public are invited to file comments,...

  19. 77 FR 10556 - Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2012-02-22

    ... COMMISSION Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U.S... Devices Containing Same, DN 2877; the Commission is soliciting comments on any public interest issues... interested parties, and members of the public are invited to file comments, not to exceed five (5) pages...

  20. 75 FR 54910 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2010-09-09

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... and Products Containing Same DN 2754; the Commission is soliciting comments on any public interest..., NY. The complainant, proposed respondents, other interested parties, and members of the public...

  1. 76 FR 35910 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2011-06-20

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... soliciting comments on any public interest issues raised by the complaint. FOR FURTHER INFORMATION CONTACT..., proposed respondents, other interested parties, and members of the public are invited to file comments,...

  2. Integrating Public Relations and Legal Responses during a Crisis: The Case of Odwalla, Inc.

    Science.gov (United States)

    Martinelli, Kathleen A.; Briggs, William

    1998-01-01

    Examines the crisis-communication strategies employed by Odwalla, Inc. during its juice contamination crisis, a crisis whose impact on public health and safety gave it the potential for developing into an issue that required public policy relief. Finds that public-relations response strategies dominated legal response strategies, followed by mixed…

  3. Sponsorship of physical activity programs by the sweetened beverages industry: public health or public relations?

    Science.gov (United States)

    Gómez, Luis; Jacoby, Enrique; Ibarra, Lorena; Lucumí, Diego; Hernandez, Alexandra; Parra, Diana; Florindo, Alex; Hallal, Pedro

    2011-04-01

    The growing evidence on the association between consumption of sugar-sweetened beverages, obesity and other chronic diseases has highlighted the need to implement policy actions that go beyond programs exclusively focused on individual responsibility. In order to protect their commercial goals in Latin America, the sugar-sweetened beverage industry practices intense lobbying at high government levels in several countries across the region. This strategy is accompanied by corporate social responsibility programs that fund initiatives promoting physical activity. These efforts, although appearing altruistic, are intended to improve the industry's public image and increase political influence in order to block regulations counter to their interests. If this industry wants to contribute to human well being, as it has publicly stated, it should avoid blocking legislative actions intended to regulate the marketing, advertising and sale of their products.

  4. Importance of public relations in recycling strategies: principles and case studies.

    Science.gov (United States)

    Salhofer, Stefan; Isaac, Nicole A

    2002-07-01

    The separate collection of waste, and especially of recyclables with specific collection systems, would not be possible without the involvement of the users. Apart from the physical installations such as collection containers, collection points, etc., the motivation of the users is an essential component. Motivation can be reinforced through public relations work. In addition to the underlying technical considerations, this paper describes the difference between communication in general and public relations and specifically examines public involvement in recycling. Through the use of examples, we look at the targeted users and typical media employed. Furthermore, we analyzes the development of public involvement. The examples show that public relations for recycling strategies relies to a great extent on attitudes, habits, and access to the target group. Thus, standardized procedures cannot be developed. For these reasons, public relation activities must be planned carefully and professionally and include an analysis of the target group, choice of media, and verification of success.

  5. Public Relations and Its Education: 21st Century Challenges in Definition, Role and Function.

    Science.gov (United States)

    Kruckeberg, Dean

    This paper asserts that the greatest challenge for 21st century public relations practitioners will be the identification of organizational values and their reconciliation with societal values within the context of a quickly and seemingly chaotic syncretizing popular culture. This function of public relations requires considerable practitioner…

  6. To Evolve Is To Involve: Student Choice in Introduction to Public Relations Classes.

    Science.gov (United States)

    Benigni, Vincent L.; Lariscy, Ruth Ann Weaver; Tinkham, Spencer F.

    2002-01-01

    Focuses on four consecutive quarters of the Introduction to Public Relations class at a university, which offers a public relations major for undergraduates and graduates. Sets out to assay the choices that students make, and analyze possible correlations between their decisions and factors such as choice of major, motivation and student…

  7. Cultural Differences in an Interorganizational Network: Shared Public Relations Firms among Japanese and American Companies.

    Science.gov (United States)

    Jang, Ha-Yong

    1997-01-01

    Investigates impact of national culture on interorganizational relationships among organizations. Matches 35 Japanese and American companies by their business types. Reveals that the network of shared public relations firms was loosely connected--American companies were more central. Indicates the network structure of shared public relations firms…

  8. Hippocrates and Bernays: A Medical Ethics Perspective on the Ethics of Public Relations.

    Science.gov (United States)

    Kruckeberg, Dean

    While comparisons of public relations practitioners and attorneys remain attractive among practitioners and scholars searching for evidence of public relation's emergence as a profession, practitioners would be better served by emulating physicians in their "healing" role rather than attorneys in their "advocacy" role. Public…

  9. Whose Freedom and Equity in Public Relations? The Gender Balance Argument.

    Science.gov (United States)

    Toth, Elizabeth Lance

    Unequal treatment, unequal value and unequal power are three aspects of the gender balance argument in public relations. The few models describing how public relations is practiced do not distinguish the component parts on the basis of gender. Such models do not consider the men and women in the intra-institutional processes as processors of…

  10. The New Rules of PR and Marketing: A Teaching Unit for College Public Relations Programs

    Science.gov (United States)

    Mauldin, Candice

    2011-01-01

    The purpose of this lesson plan is to introduce the importance of social media and the Internet on public relations and marketing. The lesson describes the new rules for public relations versus the old rules. It is a more in depth look at how, and why, to use blogging, social media, and the Internet for promoting a company and appealing to buyers.…

  11. Applying Classical Ethical Theories to Ethical Decision Making in Public Relations: Perrier's Product Recall.

    Science.gov (United States)

    Pratt, Cornelius B.

    1994-01-01

    Links ethical theories to the management of the product recall of the Perrier Group of America. Argues for a nonsituational theory-based eclectic approach to ethics in public relations to enable public relations practitioners, as strategic communication managers, to respond effectively to potentially unethical organizational actions. (SR)

  12. Public Relations in Catholic Secondary Schools: Nearly 40 Years of Continuous Improvement

    Science.gov (United States)

    James, John T.

    2004-01-01

    This article traces the phenomenal improvement in public relations efforts over the past 40 years made by Catholic secondary schools. The improvements were brought about by crises, a theological paradigm shift, professional lay involvement, a growing awareness and appreciation of public relations, competition, and increasing financial need. The…

  13. University Intervention into Community Issues as Dialogic Public Relations: A Case Study

    Science.gov (United States)

    Byrne, Jamie M.

    2007-01-01

    This paper examines a study of the wastewater collection and treatment issues of Little Rock and North Little Rock, Arkansas by University of Arkansas at Little Rock personnel and how it constitutes dialogic public relations. The paper defines dialogic public relations using Kent and Taylor's work and then uses their criteria to describe how this…

  14. An In-Depth Look at RACE: Creating a Public Relations Plan

    Science.gov (United States)

    Luttrell, Regina

    2013-01-01

    This article describes an activity in which students will understand, analyze, and apply the principles learned in the RACE process (research, action, communication, and evaluation). Students should have the ability to identify the four-step public relations planning process and ultimately create a public relations plan. This two-week activity is…

  15. Using Feature Films to Teach Public Relations: An Assessment Model from Nonmajor Students' Perspective

    Science.gov (United States)

    Mak, Angela Ka Ying; Hutton, James G.

    2014-01-01

    Teaching fundamental public relations courses to students from diverse backgrounds poses additional complexities in learning effectiveness. This exploratory study evaluated the effectiveness and identified the challenges of using films to teach public relations among nonmajor students. Results from an online survey and two focus groups found that…

  16. Don't Shoot the Messenger: Public Relations for Law Enforcement

    Science.gov (United States)

    Baxter, David S.

    2013-01-01

    This communication project provides an overview of public relations as seen through the communication arts. It is specifically focused to give law enforcement officers a general review of the practice of public relations, communication basics, and an understanding of the media. This course also provides the facilitator with multiple tools for…

  17. An Evaluative Measure for Outputs in Student-Run Public Relations Firms and Applied Courses

    Science.gov (United States)

    Deemer, Rebecca A.

    2012-01-01

    A valid, reliable survey instrument was created to be used by public relations student-run firms and other applied public relations courses to gauge client satisfaction. A series of focus groups and pilot tests were conducted to ascertain themes, refine questions, and then to refine the entire instrument. Six constructs to be measured, including…

  18. Understanding and Using the Relationships between Business and Professional Communication and Public Relations

    Science.gov (United States)

    Penrose, John M.

    2015-01-01

    Aspects of research and pedagogy from the public relations discipline can benefit the business and professional communication instructor seeking new dimensions for the business and professional communication classroom. Elements of public relations (PR) found in Association for Business Communication articles and journals may be incorporated in the…

  19. A Best Practices Service Learning Framework for the Public Relations Campaigns Course

    Science.gov (United States)

    Allison, Audrey Wilson

    2008-01-01

    Public relations curriculum often incorporates professional experience for progressive skill development. In the traditional public relations (PR) campaigns course, students typically research, develop, and implement a strategic campaign for a community organization as the client. Service learning is an effective pedagogical approach for the PR…

  20. How to achieve public participation in nuclear waste decisions: Public relations or transparent adversary science

    Energy Technology Data Exchange (ETDEWEB)

    Treichel, J. [Nevada Nuclear Waste Task Force, Las Vegas, NV (United States)

    1999-12-01

    The current US nuclear waste disposal program began with passage of the Nuclear Waste Policy Act of 1982 and was modified by the Nuclear Waste Policy Amendments Act of 1987. The Amendments Act made many major changes to the original Act, the most significant of which was the singling out of Yucca Mountain as the only site to be studied for a deep geologic high-level nuclear waste repository. While that decision appeared to simplify and streamline the program, it vastly increased the levels of public resistance and protest, particularly in Nevada. To counter the lack of public acceptance of its programs, the Department of Energy has embarked on countless efforts purportedly aimed at creating public participation. However, nuclear proponents portray a Yucca Mountain repository as inevitable. With this a foregone conclusion, it is apparent to the public that opportunities for meaningful participation do not exist - the only allowable change is in their attitudes. This is purely paternalism and, as such, it is an insult to concerned citizens. Intelligent citizens believe that they cannot play a meaningful role in the current program. Their participation amounts to joining a game or contest that is rigged. All rules, regulations and standards governing the Yucca Mountain project are either changing or proposed to be changed. In a game of golf, players cannot determine their handicap midway through the course. While there are jokes told about such actions in sports, a nuclear waste policy is no laughing matter. In this case, the game, or site characterization program, is now referred to by many as 'advocacy science'. With Yucca Mountain as the only site, and the frantic cries of the commercial nuclear utilities that the lack of a disposal site is a national crisis, the investigations of the site appear to watchful citizens to be aimed at proving its suitability, rather than an objective study. Risk Assessment and risk communication, while very useful when

  1. Blockade of Tumor Necrosis Factor-Alpha: A Role for Adalimumab in Neovascular Age-Related Macular Degeneration Refractory to Anti-Angiogenesis Therapy

    Directory of Open Access Journals (Sweden)

    Beatriz Fernández-Vega

    2016-03-01

    Full Text Available Aims: To report a case of wet age-related macular degeneration (wet-AMD refractory to intravitreal anti-vascular endothelial growth factor (anti-VEGF therapy in a patient who showed visual and anatomical improvement and stabilization after starting a subcutaneous treatment course with adalimumab, an anti-tumor necrosis factor-alpha (TNF-α drug, for concomitant Crohn's disease. Methods: Observational case report of a female patient. Ophthalmological evaluation was performed by slit lamp and ophthalmoscopy (posterior pole and anterior segment. Best-corrected visual acuity (BCVA was determined, and imaging was performed by fluorescein angiography, indocyanine green angiography, and optical coherence tomography (OCT. Intravitreal therapies used and treatment with anti-TNF-α were recorded. Results: A 64-year-old woman with wet-AMD was treated with fourteen intravitreal injections of ranibizumab (0.5 mg for a period of 40 months with intervals of 1-6 months. She initially showed a good visual and anatomical response to periodic anti-VEGF treatment but during check visits, anatomical and functional responses deteriorated. At the 40-month follow-up, the patient had developed Crohn's disease, and her rheumatologist started treatment with adalimumab (40 mg subcutaneously every 2 weeks. During the 25 months of treatment with adalimumab, the patient did not require any additional intravitreal anti-VEGF treatments because her BCVA, clinical, and OCT findings improved and remained stable. Conclusions: We described a case of a patient with wet-AMD refractory to anti-VEGF therapy, which clinically benefited from subcutaneous adalimumab therapy. Treatment with subcutaneous anti-TNF-α in combination with anti-VEGF therapy avoids the high cost and risks related to multiple intravitreal anti-VEGF injections with good functional and anatomic outcomes.

  2. Public Relations for Principals. "A Guidebook for the Pennsylvania Administrator."

    Science.gov (United States)

    Pennsylvania School Boards Association, Inc., Harrisburg.

    This report discusses what makes news, what people want to read, and how to write news releases or other informative bulletins and brochures. Also included are a description of principal-reporter-editor relations, some layout and typography data, and photography instructions. (JF)

  3. Cinema Spin: Exploring Film Depictions of Public Relations Practitioners

    Science.gov (United States)

    Lambert, Cheryl Ann

    2011-01-01

    Films have been used successfully to teach students about "the institutional and cultural role mass media play in creating, sustaining or changing social relations." They have also provided important lessons regarding ethical decision-making. This article presents an activity that enables students to understand the role of media and the concept of…

  4. Genetic engineering in agriculture and corporate engineering in public debate: risk, public relations, and public debate over genetically modified crops.

    Science.gov (United States)

    Patel, Rajeev; Torres, Robert J; Rosset, Peter

    2005-01-01

    Corporations have long influenced environmental and occupational health in agriculture, doing a great deal of damage, making substantial profits, and shaping public debate to make it appear that environmental misfortunes are accidents of an otherwise well-functioning system, rather than systemic. The debate over the genetically modified (GM) crops is an example. The largest producer of commercial GM seeds, Monsanto, exemplifies the industry's strategies: the invocation of poor people as beneficiaries, characterization of opposition as technophobic or anti-progress, and portrayal of their products as environmentally beneficial in the absence of or despite the evidence. This strategy is endemic to contemporary market capitalism, with its incentives to companies to externalize health and environmental costs to increase profits.

  5. Role of angiogenesis in chronic lymphocytic leukemia.

    Science.gov (United States)

    Letilovic, Tomislav; Vrhovac, Radovan; Verstovsek, Srdan; Jaksic, Branimir; Ferrajoli, Alessandra

    2006-09-01

    Angiogenesis is a physiologic process of new blood vessels formation mediated by various cytokines called angiogenic and angiostatic factors. Although its potential pathophysiologic role in solid tumors has been extensively studied for more than 3 decades, enhancement of angiogenesis in chronic lymphocytic leukemia (CLL) and other malignant hematological disorders has been recognized more recently. An increased level of angiogenesis has been documented by various experimental methods both in bone marrow and lymph nodes of patients with CLL. Although the role of angiogenesis in the pathophysiology of this disease remains to be fully elucidated, experimental data suggest that several angiogenic factors play a role in the disease progression. Biologic markers of angiogenesis were also shown to be of prognostic relevance in CLL. The current findings provide the rationale for investigating antiangiogenic agents in CLL. In the current review angiogenesis in CLL is discussed and its potential diagnostic and therapeutic applications.

  6. Angiogenesis and Anti-Angiogenic Treatments

    Directory of Open Access Journals (Sweden)

    Ersin Demirer

    2013-10-01

    Full Text Available Blood vessels in our body is developed by vasculogenesis and angiogenesis. There have been new advances in molecular pathology and tumor biology areas in recent years. Angiogenesis is modulated by the balance between angiogenic and anti-angiogenic factors. Angiogenesis plays a key role in tumor growth. Drugs inhibiting angiogenesis have been in use in various malign or non-malign diseases. Inhibition of angiogenesis in malign diseases is a very attractive subject in medicine and studies are going on about long term affects and toxicities. Inhibition of angiogenesis is not an only treatment choice alone. It is a supplemental treatment option applied with conventional chemotherapy, radiotherapy, surgery, immunotherapy and hormonal therapy. It has been used in colorectal carcinoma, renal cell carcinoma, non-small cell lung cancer, glioblastoma, heoatocellular carcinoma, pancreatic neuroendocrine tumor, tyroid medullary cancer.

  7. Monitoring angiogenesis using magnetic resonance methods

    DEFF Research Database (Denmark)

    Holm, David Alberg

    2008-01-01

    adults where it is primaily found in wound healing, pregnancy and during the menstrual cycle. This thesis focus on the negative consequences of angiogenesis in cancer. It consists of a an initial overview followed by four manuscripts. The overview gives a short introduction to the process of angiogenesis......When a tumor reaches a certain size it can no longer rely on passive perfusion for nutrition. The tumor therefore emits signaling molecules which stimulating surrounding vessels to divide and grow towards the tumor, a process known as angiogenesis. Very little angiogenesis is present in healthy...... and the involved signaling molecules. Subsequently, a short review of contrast agents and perfusion measurements is given. Finally, methods for monitoring angiogenesis using magnetic resonance imaging are reviewed. A method for monitoring early stages of angiogenesis as well as the effect of anti...

  8. Public Relations: Ketchum brands new product with innovative PR strategy.

    Science.gov (United States)

    2006-01-01

    Novartis Pharmaceuticals tapped publis relations (PR) giant Ketchum earlier this year to spearhead a marketing campaign that would make its new U.S. Food and Drug Administration-approved prescription-based medication, Enablex, stand out among the crowd in over active bladder (OAB) treatment. OAB is a disorder that affects an estimated 33 million Americans making this treatment highly in demand with consumers and highly competitive with other pharmaceutical companies.

  9. Relations of power in public schools: a case study

    Directory of Open Access Journals (Sweden)

    Maria Custódia Jorge Rocha

    2014-04-01

    Full Text Available In this paper, based on a few authors who see power as a substantive element – instituted power – and others who consider it as an action verb – instituting power (ROCHA, 2007 –, highlighting some types of power relevant in sociological and organizational research on schools, we present empirical data and institutional discourses, enabled by a case study of qualitative nature. Thus, we can say that relations of power in schools both allow the strengthening of hierarchical and asymmetrical relations of power that exist between institutional players and enable the creation of new “circles of power” that can be promptly activated or can be object of a modernization process held in a more or less generalized manner. This may be reinforced and introduced to players/students, our main target of study, as the most legitimate object, superseding all others but not canceling them. The key objective is to present school organization as a highly complex environment, especially when considered in the light of the multiple and cumulative relations of power that emerge and are materialized.

  10. Hypoxia independent drivers of melanoma angiogenesis

    Directory of Open Access Journals (Sweden)

    Svenja eMeierjohann

    2015-05-01

    Full Text Available Tumor angiogenesis is a process which is traditionally regarded as the tumor`s response to low nutrient supply occurring under hypoxic conditions. However, hypoxia is not a prerequisite for angiogenesis. The fact that even single tumor cells or small tumor cell aggregates are capable of attracting blood vessels reveals the early metastatic capability of tumor cells. This review sheds light on the hypoxia independent mechanisms of tumor angiogenesis in melanoma.

  11. The effects of communication techniques on public relation activities: A sample of hospitality business

    Directory of Open Access Journals (Sweden)

    Şirvan Şen Demir

    2011-07-01

    Full Text Available Nowadays, firms who give importance to public relations have been increasing rapidly in numbers. All modern firms either found public relations department in their body to deal with public relations operations or outsource this activity to consultants in order to communicate with target populations. Among the firms in tourism sector, hospitality companies are the ones that use public relations the most. The purpose of this study is to investigate the communication techniques in public relation and effects of these techniques on public relation activities. A literature review was conducted for research model and then questionnaire was developed from the studies in the literature. Data were collected by researchers in face-to-face interviews with 145 supervisors who are responsible for public relation activities of the hotel and were analyzed with SPSS statistical programs. Structural and convergent validity of the data have revealed with the explanatory factor analysis. It was tested using a regression analysis to determine the effects of independent variables on dependent variables. As a result, independent variables have positive effects on the dependent variables.

  12. Linking public relations processes and organizational effectiveness at a state health department.

    Science.gov (United States)

    Wise, Kurt

    2003-01-01

    This qualitative case study explored a state health department's relationships with strategic constituencies from a public relations perspective. The relationships were explored within the theoretical framework of the Excellence Theory, the dominant paradigm in public research. Findings indicate application of the Excellence Theory has the potential to increase organizational effectiveness at public health entities. With respect to the case investigated, findings indicate that the state health department could increase its organizational effectiveness through the adoption of recommendations based on the Excellence Theory.

  13. Angiogenesis dysregulation in term asphyxiated newborns treated with hypothermia.

    Directory of Open Access Journals (Sweden)

    Henna Shaikh

    Full Text Available Neonatal encephalopathy following birth asphyxia is a major predictor of long-term neurological impairment. Therapeutic hypothermia is currently the standard of care to prevent brain injury in asphyxiated newborns but is not protective in all cases. More robust and versatile treatment options are needed. Angiogenesis is a demonstrated therapeutic target in adult stroke. However, no systematic study examines the expression of angiogenesis-related markers following birth asphyxia in human newborns.This study aimed to evaluate the expression of angiogenesis-related protein markers in asphyxiated newborns developing and not developing brain injury compared to healthy control newborns.Twelve asphyxiated newborns treated with hypothermia were prospectively enrolled; six developed eventual brain injury and six did not. Four healthy control newborns were also included. We used Rules-Based Medicine multi-analyte profiling and protein array technologies to study the plasma concentration of 49 angiogenesis-related proteins. Mean protein concentrations were compared between each group of newborns.Compared to healthy newborns, asphyxiated newborns not developing brain injury showed up-regulation of pro-angiogenic proteins, including fatty acid binding protein-4, glucose-6-phosphate isomerase, neuropilin-1, and receptor tyrosine-protein kinase erbB-3; this up-regulation was not evident in asphyxiated newborns eventually developing brain injury. Also, asphyxiated newborns developing brain injury showed a decreased expression of anti-angiogenic proteins, including insulin-growth factor binding proteins -1, -4, and -6, compared to healthy newborns.These findings suggest that angiogenesis pathways are dysregulated following birth asphyxia and are putatively involved in brain injury pathology and recovery.

  14. New molecular connections in angiogenesis

    Institute of Scientific and Technical Information of China (English)

    Qiling Xu; David Wilkinson

    2010-01-01

    @@ In vertebrates, oxygen and nutrients are delivered to tissues by the circula-tion of blood through vessels, comprised of a branched network of endothelial tubes termed the vasculature. Crucial for the formation of blood vessels during development is the process of angiogenesis, in which new sprouts form from pre-existing vessels in a complex cascade of cellular events. This involves the activation of an endothelial cell in the vessel to become a highly exploratory 'tip' cell that migrates to invade the surrounding tissues, while remaining tightly connected to the fol-lowing cells that subsequently generate the tubular structures of a new vessel.

  15. 76 FR 11266 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2011-03-01

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... Commission is soliciting comments on any public interest issues raised by the complaint. FOR FURTHER... Chandler, AZ. The complainant, proposed respondents, other interested parties, and members of the...

  16. 76 FR 25706 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2011-05-05

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... public interest issues raised by the complaint. FOR FURTHER INFORMATION CONTACT: James R. Holbein, Acting... Diego, CA. The complainant, proposed respondents, other interested parties, and members of the...

  17. 76 FR 36935 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2011-06-23

    ... COMMISSION Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest AGENCY: U... Components Thereof, DN 2819; the Commission is soliciting comments on any public interest issues raised by... County, CA. The complainant, proposed respondents, other interested parties, and members of the...

  18. The Client-Centered Approach as a Foundation for Teaching the Introductory Course in Public Relations.

    Science.gov (United States)

    Najor, Michele A.; Motschall, Melissa

    2001-01-01

    Describes how the authors use a broad-based, client-centered model to teach an introductory course in public relations, integrating writing assignments for "clients" into course topics, which include history, ethics, theory, research, program planning, publicity, crisis management, and evaluation methods. Discusses course objectives, and notes…

  19. 76 FR 57740 - Program Requirement Revisions Related to the Public Water System Supervision Programs for the...

    Science.gov (United States)

    2011-09-16

    ... AGENCY Program Requirement Revisions Related to the Public Water System Supervision Programs for the... the process of revising their respective approved Public Water System Supervision (PWSS) programs to meet the requirements of the Safe Drinking Water Act (SDWA). The State of Rhode Island has...

  20. Opportunity to Improve Public Perceptions of Arthropods and Arthropod-Related Benefits

    Science.gov (United States)

    Harris, Bethany A.; Braman, S. Kristine

    2016-01-01

    The general public may not recognize the value of conserving insects and spiders in home landscapes. We surveyed individuals to assess public perceptions of 10 arthropods--nine common insects and one common spider species--and to determine whether arthropod-related attitudes could be altered. Additionally, we collected data on survey respondent…

  1. School Public Relations: Helping an American Institution Pass Its Most Crucial Test

    Science.gov (United States)

    Boyd, Ellen

    2004-01-01

    The professional discipline of strategic public relations offers many benefits to organizations. It helps them prevent and mitigate crises. It allows them to identify and manage issues that may interfere with their goals and objectives. It also leads them in building and maintaining quality relationships with strategic publics. However, can the…

  2. Humor in High School and the Role of Teacher Leaders in School Public Relations

    Science.gov (United States)

    Kosiczky, Bonnie; Mullen, Carol A.

    2013-01-01

    How can public schools improve public relations strategies, particularly in communications between teachers and students? The purposes of this study were to investigate teacher leaders' perceptions of the use of humor in the high school classroom and discover how humor might bridge instruction to student learning and strengthen teacher-student…

  3. Engaging Communities through Vision Development: A Systems Approach to Public Relations

    Science.gov (United States)

    Chance, Patty L.

    2005-01-01

    The implementation of No Child Left Behind (NCLB) federal legislation in 2001 exemplifies extreme reaction to an escalating public unrest with educational systems over the past several decades of "educational reform." Effective public relations and communication with stakeholders is threatened during this time of increased public…

  4. Toastmaster's Inspired Pedagogical Changes: From a Speech Class into a Public Relations Course

    Science.gov (United States)

    Shadinger, David

    2016-01-01

    Action research is used to view pedagogical changes, first in a speech class and then in a public relations course over a five-year period. The course instructor gained experience as a member of a Toastmasters International club and used Toastmasters-like activities, to revise content in the courses. Ultimately, students in the public relations…

  5. The Role of a Single Angiogenesis Inhibitor in the Treatment of Recurrent Glioblastoma Multiforme: A Meta-Analysis and Systematic Review.

    Directory of Open Access Journals (Sweden)

    Yawei Wang

    Full Text Available Currently, the standard treatment for newly diagnosed glioblastoma multiforme (GBM is maximal safe surgical resection followed by radiation therapy with concurrent and adjuvant temozolomide. However, disease recurs in almost all patients, and the optimal salvage treatment for recurrent GBM remains unclear. We conducted a systematic review and meta-analysis of published clinical trials to assess the efficacy and toxicities of angiogenesis inhibitors alone as salvage treatment in these patients.Trials published between 1994 and 2015 were identified by an electronic search of public databases (MEDLINE, EMBASE, Cochrane library. Demographic data, treatment regimens, objective response rate (ORR, median progression-free survival (PFS, median overall survival (OS, 6-months PFS rate, 1-year OS and grade 3/4 toxicities were extracted. We also compared the main outcomes of interest between bevacizumab and other angiogenesis inhibitors. All analyses were performed using Comprehensive Meta Analysis software (Version 2.0.A total of 842 patients were included for analysis: 343 patients were treated with bevacizumab, 386 with other angiogenesis inhibitors and 81 with thalidomide. The pooled ORR, 6-months PFS, and 1-year OS for recurrent GBM patients receiving angiogenesis inhibitors was 20.1%, 19.5% and 29.3%, respectively. The use of single agent bevacizumab in recurrent GBM significantly improved ORR and 6-months PFS when compared to other angiogenesis inhibitors [relative risk (RR 2.93, 95% CI 1.38-6.21; p = 0.025; and RR 2.36 95% CI 1.46-3.82; p<0.001, respectively], while no significant difference in 1-year OS was found between the two groups (p = 0.07. when compared to thalidomide, bevacizumab treatment in recurrent GBM significantly improved ORR (RR 6.8, 95%CI: 2.64-17.6, p<0.001, but not for 6-months PFS (p = 0.07 and 1-year OS (p = 0.31. As for grade 3/4 toxicities, the common toxicity was hypertension with pooled incidence of 12.1%, while high

  6. 78 FR 44959 - Public Workshop Related to the International Maritime Organization's Development of a Mandatory...

    Science.gov (United States)

    2013-07-25

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOMELAND SECURITY Coast Guard Public Workshop Related to the International Maritime Organization's Development of a... International Maritime Organization (IMO Polar Code). Various safety topics will be discussed including...

  7. Bibliography of scientific publications and presentations relating to planetary quarantine: 1966 - 1971

    Science.gov (United States)

    Bradley, F. D.; Nadel, M. R.

    1973-01-01

    A bibliography, which is a compilation of citations relating to planetary quarantine, previously listed in similar publications since 1967, is presented to provide a reference for reviewing planetary quarantine research and development.

  8. Key issues of public relations of Europe: Findings from the European Communication Monitor 2007-2014

    Directory of Open Access Journals (Sweden)

    Dejan Vercic

    2014-10-01

    Full Text Available European Communication Monitor is the largest longitudinal research project in public relations practice in the world. Data collected annually from 2007 to 2014 show that practitioners perceive five issues as the most important for their work: linking business strategy and communication, coping with the digital evolution and social web, building and maintaining trust, dealing with the demand for more transparency and active audiences, and dealing with the speed and volume of information flow. Perception of the importance of various issues for the practice of public relations is largely dependent on the gender, geography (division between Northern and Western vs. Southern and Eastern Europe, and sector in which a practitioner works (corporate, government, NGO or agency. While gender and sectorial differences studied in academic public relations literature, divisions in public relations practice between North-Western and South-Eastern Europe are largely ignored.

  9. Should You Know How to Do Marketing, Advertising, & Public Relations Writing?

    Science.gov (United States)

    Sides, Charles H.

    1992-01-01

    Argues that technical writers who develop broader writing skills prove to be more valuable to their employers during periods of economic downturn. Offers an overview of the basic skills needed to write marketing, advertising, and public relations documents. (PRA)

  10. Complex role of matrix metalloproteinases in angiogenesis

    Institute of Scientific and Technical Information of China (English)

    SANGQINGXIANGAMY

    1998-01-01

    Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) play a significant role in regulating angiogenesis,the process of new blood vessel formation.Interstitial collagenase (MMP-1),72kDa gelatinase A/type IV collagenase (MMP-2),and 92 kDA gelatinase B/type IV collagenase (MMP-9) dissolve extracellular matrix (ECM) and may initiate and promote angiogenesis.TIMP-1,TIMP-2,TIMP-3,and possibly,TIMP-4 inhibit neovascularization.A new paradign is emerging that matrilysin (MMP-7),MMP-9,and metalloelastase (MMP-12) may block angiogenesis by converting plasminogen to angiostatin,which is one of the most potent angiogenesis antagonists.MMPs and TIMPs play a complex role in regulating angiogenesis.An understanding of the biochemical and cellular pathways and mechanisms of angiogenesis will provide important information to allow the control of angiogenesis,e.g.the stimulation of angiogenesis for coronary collateral circulation formation;while the inhibition for treating arthritis and cancer.

  11. A typology of health marketing research methods--combining public relations methods with organizational concern.

    Science.gov (United States)

    Rotarius, Timothy; Wan, Thomas T H; Liberman, Aaron

    2007-01-01

    Research plays a critical role throughout virtually every conduit of the health services industry. The key terms of research, public relations, and organizational interests are discussed. Combining public relations as a strategic methodology with the organizational concern as a factor, a typology of four different research methods emerges. These four health marketing research methods are: investigative, strategic, informative, and verification. The implications of these distinct and contrasting research methods are examined.

  12. Defining the public, defining sociology: hybrid science-public relations and boundary-work in early American sociology.

    Science.gov (United States)

    Evans, Michael S

    2009-01-01

    In this paper, I examine how scientific disciplines define their boundaries by defining the publics with whom they engage. The case study is an episode in the development of early American sociology. In response to the dual challenge of credibility set up by the conflict between religious Baconian science and secular positivist science, key actors engaged in specific strategies of boundary-work to create their desired "sociological public"--a hybrid form of science-public relations that appealed to hostile university scientists while excluding a supportive religious audience from participation in the production of scientific knowledge. Using this case, I offer two specific insights. First I illustrate how, in the pursuit of scientific credibility, actors engage in boundary-work to differentiate audiences, not just practitioners. Such defining of publics is constitutive of scientific disciplines in their formative stage. Second, I demonstrate how audience boundaries can be redefined through the capture of existing boundary objects. Specifically, the removal of informational content in key boundary objects creates durable boundaries that are difficult to overcome.

  13. PUBLIC RELATIONS ON THE EDUCATIONAL MARKET OF REPUBLIC OF TATARSTAN: HISTORY AND PROSPECTS

    Directory of Open Access Journals (Sweden)

    Olga Vladimirovna Kozlova

    2014-10-01

    Full Text Available Modern domestic science designed periodization of the development of public relations in Russia as a kind of professional activity. The authors traced the path of development of public relations as an academic specialty at the federal and regional levels (the experience of the Republic of Tatarstan. The chronological scope of the study: 1990 - to the present day. Characteristic features of the educational market of Tatastan are: demographic "failure", the reduction of budget places on humanitarian academic programs, high competition among universities.The purpose of the study was to examine the possibilities of using the tools of integrated marketing communications in promotion of academic program «Advertising and Public Relations» (BA in the educational market of the Republic of Tatarstan.Data for this study were collected by the experience of the Department of History and Public Relations of the Kazan National Research Technical University named after A.N. Tupolev.The Methods of the undertaking the work: theoretical analysis, sociological survey, information audit, interviews.The results of the study show the necessity to use these tools to promote academic program «Advertising and Public Relations»: advertising, public relations, special events, exhibition activities, Internet communications, direct marketing, and informal communication.

  14. A CONSOLIDATED MODEL OF ANALYSIS OF THE RELATIONS BETWEEN POLITICS AND MANAGEMENT WITHIN PUBLIC ORGANIZATIONS

    Directory of Open Access Journals (Sweden)

    Catalina Maria GEORGESCU

    2011-01-01

    Full Text Available An interdisciplinary approach which combines the theoretical, empirical andconceptual dimensions, the present study tries to offer a new workperspective on the assessment and modeling of the relation between themanagement of public organizations and the political environment. Thetheoretical research was centered on reviewing the literature on the relationbetween the management of public organizations and the politicalenvironment. The empirical research was materialized by modeling with theregression technique of several aspects integrated to the relations betweenthe management of human resources within public organizations in theeducation field and the external political environment.

  15. THE ROLE OF PUBLIC RELATIONS IN SOCIAL RESPONSIBILITY OF ROMANIAN ENTERPRISES

    Directory of Open Access Journals (Sweden)

    Nicoleta CRISTACHE

    2006-01-01

    Full Text Available The Excellence study has shown that public relations is an unique management function that helps an organisation interact with social and political components of its environment. These components make up the institutional environment of an organisation, which consist of publics that affect the ability of the organisation to accomplish its goals and that expect organisations to help them accomplish their own goals. Organisations solve problems for society, but they also create problems for society. The value of public relations, therefore, can be determined by measuring the quality of relationships it establishes with the strategic components of its institutional environment.

  16. Immunotherapy of tumor by targeting angiogenesis

    Institute of Scientific and Technical Information of China (English)

    HOU Jianmei; TIAN Ling; WEI Yuquan

    2004-01-01

    Tumor growth and metastasis are angiogenesis-dependent. Anti-angiogenic therapy represents a new strategy for the development of anti-cancer therapies. In recent years, there has been made great progress in anti-angiogenic therapy. As far as the passive immunotherapy is concerned, a recombinant humanized antibody to vascular endothelial growth factor (VEGF)-Avastin has been approved by FDA as the first angiogenesis inhibitor to treat colorectal cancer. For active specific immunotherapy, various strategies for cancer vaccines, including whole endothelial cell vaccines, dendritic cell vaccines, DNA vaccines, and peptides or protein vaccines, have been developed to break immune tolerance against important molecules associated with tumor angiogenesis and induce angiogenesis-specific immune responses. This article reviews the angiogenesis-targeted immunotherapy of tumor from the above two aspects.

  17. EFFECT OF TURKISH PUBLIC DIPLOMACY ACTIVITIES ON RELATIONS BETWEEN TURKEY AND GEORGIA

    Directory of Open Access Journals (Sweden)

    Sinem Celik

    2016-11-01

    Full Text Available The aim of this article is to analyze the impact power of Turkish public diplomacy performed towards Georgia to empower the relation between both countries. Within the scope of this article, after public diplomacy term was discussed in many aspects, some of the important activities of the actors of Turkish public diplomacy have also been mentioned. When these activities are examined, it has been observed that non-governmental organizations failed to show the desired level of asset compared to government agencies in Georgia. Besides, when Turkish public diplomacy activities are examined as a whole, it has been remarked that these activities play an effective role to gain the sympathy of the Georgian. However, it has been concluded that the impacts of these activities on Turkey- Georgia relations are limited especially due to the Russian influence on relations with each of these two countries.

  18. Imaging of angiogenesis in cardiology

    Energy Technology Data Exchange (ETDEWEB)

    Higuchi, Takahiro; Wester, Hans Juergen; Schwaiger, Markus [Nuklearmedizinische Klinik und Poliklinik der Technischen Universitaet Muenchen, Klinikum rechts der Isar, Munich (Germany)

    2007-06-15

    In the past decade, there have been major improvements in our understanding of angiogenesis at the genetic, molecular and cellular levels. Concentrated efforts in this area have led to new therapeutic approaches to ischaemic heart disease using angiogenic factors, gene therapy and progenitor cells. Despite very promising experimental results in animal studies, large clinical trials have failed to confirm the results in patients with coronary artery disease. Important questions such as selection of growth factors and donor cells, as well as the timing, dose and route of administration, have been raised and need to be answered. Molecular imaging approaches which may provide specific markers of the angiogenic process (e.g. integrin expression in endothelial cells) have been introduced and are expected to address some of these questions. Although few clinical imaging results are currently available, animal studies suggest the potential role of molecular imaging for characterisation of the angiogenetic process in vivo and for the monitoring of therapeutic effects. (orig.)

  19. Labelled drug-related public expenditure in relation to gross domestic product (GDP) in Europe: a luxury good?

    Science.gov (United States)

    Prieto, Luis

    2010-05-17

    "Labelled drug-related public expenditure" is the direct expenditure explicitly labelled as related to illicit drugs by the general government of the state. As part of the reporting exercise corresponding to 2005, the European Monitoring Centre for Drugs and Drug Addiction's network of national focal points set up in the 27 European Union (EU) Member States, Norway, and the candidates countries to the EU, were requested to identify labelled drug-related public expenditure, at the country level. This was reported by 10 countries categorised according to the functions of government, amounting to a total of EUR 2.17 billion. Overall, the highest proportion of this total came within the government functions of Health (66%), and Public Order and Safety (POS) (20%). By country, the average share of GDP was 0.023% for Health, and 0.013% for POS. However, these shares varied considerably across countries, ranging from 0.00033% in Slovakia, up to 0.053% of GDP in Ireland in the case of Health, and from 0.003% in Portugal, to 0.02% in the UK, in the case of POS; almost a 161-fold difference between the highest and the lowest countries for Health, and a 6-fold difference for POS. Why do Ireland and the UK spend so much in Health and POS, or Slovakia and Portugal so little, in GDP terms? To respond to this question and to make a comprehensive assessment of drug-related public expenditure across countries, this study compared Health and POS spending and GDP in the 10 reporting countries. Results found suggest GDP to be a major determinant of the Health and POS drug-related public expenditures of a country. Labelled drug-related public expenditure showed a positive association with the GDP across the countries considered: r = 0.81 in the case of Health, and r = 0.91 for POS. The percentage change in Health and POS expenditures due to a one percent increase in GDP (the income elasticity of demand) was estimated to be 1.78% and 1.23% respectively. Being highly income elastic

  20. Labelled drug-related public expenditure in relation to gross domestic product (GDP) in Europe: a luxury good?

    LENUS (Irish Health Repository)

    Prieto, Luis

    2010-01-01

    "Labelled drug-related public expenditure" is the direct expenditure explicitly labelled as related to illicit drugs by the general government of the state. As part of the reporting exercise corresponding to 2005, the European Monitoring Centre for Drugs and Drug Addiction\\'s network of national focal points set up in the 27 European Union (EU) Member States, Norway, and the candidates countries to the EU, were requested to identify labelled drug-related public expenditure, at the country level. This was reported by 10 countries categorised according to the functions of government, amounting to a total of EUR 2.17 billion. Overall, the highest proportion of this total came within the government functions of Health (66%), and Public Order and Safety (POS) (20%). By country, the average share of GDP was 0.023% for Health, and 0.013% for POS. However, these shares varied considerably across countries, ranging from 0.00033% in Slovakia, up to 0.053% of GDP in Ireland in the case of Health, and from 0.003% in Portugal, to 0.02% in the UK, in the case of POS; almost a 161-fold difference between the highest and the lowest countries for Health, and a 6-fold difference for POS. Why do Ireland and the UK spend so much in Health and POS, or Slovakia and Portugal so little, in GDP terms? To respond to this question and to make a comprehensive assessment of drug-related public expenditure across countries, this study compared Health and POS spending and GDP in the 10 reporting countries. Results found suggest GDP to be a major determinant of the Health and POS drug-related public expenditures of a country. Labelled drug-related public expenditure showed a positive association with the GDP across the countries considered: r = 0.81 in the case of Health, and r = 0.91 for POS. The percentage change in Health and POS expenditures due to a one percent increase in GDP (the income elasticity of demand) was estimated to be 1.78% and 1.23% respectively. Being highly income elastic

  1. The role of public relations for image creating in health services: a sample patient satisfaction survey.

    Science.gov (United States)

    Kirdar, YalçIn

    2007-01-01

    This study discusses the role of public relations for image creating in health services. Hospitals require public relations activities to distinguish them from competitors, provide bidirectional communication between the society and the hospital, and assist to create of a strong hospital image and culture. A satisfaction survey was conducted on 264 patients who have received health services at Maltepe University Hospital. The research focused on how the Hospital's examination, care, catering and physical services; doctor and nurse politeness towards patients and patient relatives, their attitudes and behaviors; examination, check-in, bedding and discharge operations; public relations activities in and out of the hospital were perceived. Another subject of the study was the degree of recommendation of patients who have been served by the hospital's health services to prospective patients seeking treatment.

  2. Angiogenesis-associated crosstalk between collagens, CXC chemokines, and thrombospondin domain-containing proteins

    OpenAIRE

    Rivera, Corban G; Bader, Joel S.; Popel, Aleksander S

    2011-01-01

    Excessive vascularization is a hallmark of many diseases including cancer, rheumatoid arthritis, diabetic nephropathy, pathologic obesity, age-related macular degeneration, and asthma. Compounds that inhibit angiogenesis represent potential therapeutics for many diseases. Karagiannis and Popel (PNAS, 2008) used a bioinformatics approach to idenify more than 100 peptides with sequence homology to known angiogenesis inhibitors. The peptides could be grouped into families by the conserved domain...

  3. 77 FR 19672 - Draft Guidances Relating to the Development of Biosimilar Products; Public Hearing; Request for...

    Science.gov (United States)

    2012-04-02

    ... guidances relating to the development of biosimilar products. The document published with an incorrect date... HUMAN SERVICES Food and Drug Administration Draft Guidances Relating to the Development of Biosimilar Products; Public Hearing; Request for Comments; Correction AGENCY: Food and Drug Administration,...

  4. Public Employee Impasse Resolution by Judicial Order: The Nebraska Court of Industrial Relations

    Science.gov (United States)

    Good, Wallace E.

    1973-01-01

    Discusses Nebraska's approach to public employee relations, the Nebraska Court of Industrial Relations. Suggests that the pattern developed in Nebraska, although it may appear somewhat more accidental than intentional, may offer a model to other States for strengthening impasse resoltuion machinery. (Author/JF)

  5. Treachery by Any Other Name: A Case Study of the Toshiba Public Relations Crisis.

    Science.gov (United States)

    Hobbs, Jeffrey D.

    1995-01-01

    Explains that the battle to protect a corporation's image is critical during a crisis. Examines Toshiba's decision to sell weapons technology to the Soviet Union. Relates how the concept of "apologia" was used for insight into Toshiba's handling of the crisis. Argues that public relations in an image crisis is a battle for…

  6. 48 CFR 1631.205-70 - FEHBP public relations and advertising costs.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true FEHBP public relations and advertising costs. 1631.205-70 Section 1631.205-70 Federal Acquisition Regulations System OFFICE OF PERSONNEL... relations and advertising costs. (a) The cost of media messages that are directed at advising current...

  7. 48 CFR 2131.205-1 - Public relations and advertising costs.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Public relations and advertising costs. 2131.205-1 Section 2131.205-1 Federal Acquisition Regulations System OFFICE OF PERSONNEL... relations and advertising costs. The provisions of FAR 31.205-1 shall be modified to include the...

  8. National Technology Standards for K-12 Schools: A Case Study of Unresolved Issues in Public Relations

    Science.gov (United States)

    Mullen, Carol A.; Kealy, William A.; Sullivan, Ashley

    2004-01-01

    This article addresses an important need--the dissemination of information relating to technology as a public relations tool--and the associated exigency for administrator and teacher technology training. Specifically, we identify the increased expectations for the performance of school leaders and teachers, as well as unresolved issues in public…

  9. Review of Selected Dissertations Addressing School Public Relations, Administrator Communication, and Conflict Resolution

    Science.gov (United States)

    Decman, John M.; Simieou, Felix, III

    2009-01-01

    This article is an extension to Kowalski's (2005) identification of possible lines of scholarly inquiry into themes related to schools and public relations. The article first cites professional accreditation standards for educational leaders as significant factors in providing a framework for increased scholarly inquiry. It then summarizes the…

  10. AN EVALUATION OF THE PROBLEMS OF TURKISH PUBLIC ADMINISTRATION FROM THE POINT OF VIEW OF PUBLIC RELATIONS

    OpenAIRE

    Yildirim, Murat

    2010-01-01

    One of the basic problems of Turkish public administration is its distrustfulness against both to the public and its own staff. Similarly, the public don’t trust the public administration which is insensitive to their own expectations, desires and necessities. This sense of distrustfulness leads both to the administration’s introvertedness and its the lack of sensivity against the public, and at the same time the alienation of the public against the administration. The weakness of the reflexe...

  11. ATTITUDE OF PLUS TWO STUDENTS TOWARDS PUBLIC EXAMINATION IN RELATION TO PARENTAL PRESSURE

    OpenAIRE

    S. Vinolin Chrysolyte; Dr. B. William Dharma Raja

    2016-01-01

    This study examines the attitude of plus two students towards public examination and its relationship with parental pressure. The sample of the study comprised of 386 plus two students from Tirunelveli district. The authors employed survey method for collecting the data and they were analysed using descriptive and inferential statistical techniques. It was found that there is a significant relation between the attitude of students towards +2 public examination and parental pressure.

  12. Private Administration – Favorable Environment for Implementing Programs and Campaigns of Public Relations?

    Directory of Open Access Journals (Sweden)

    Simona HAIDAU

    2012-11-01

    Full Text Available This paper refer to decision of the private administration organizations from the region northeast of Romania to implement programs and public relations campaigns from the socio-economic context in the current period. This decision of organizations above mentioned is strongly influenced by nature non-profit purposes they have, more precisely, to be involved in carrying out the public interest or community.

  13. Competencies Needed in Oral Communication in English among Thai Undergraduate Public Relations Students: A Substantial Gap between Expectations and Reality

    Science.gov (United States)

    Pattanapichet, Fasawang; Chinokul, Sumalee

    2011-01-01

    This article investigates the competencies needed for oral communication in English among Thai undergraduate public relations students for handling public relations job interviews and performing entry-level public relations work. To identify these competencies, the study identified and involved all of the stakeholders in the data reliability…

  14. "I Like to Plan Events": A Document Analysis of Essays Written by Applicants to a Public Relations Program

    Science.gov (United States)

    Taylor, Ronald E.

    2016-01-01

    A document analysis of 249 essays written during a 5-year period by applicants to a public relations program at a major state university in the southeast suggests that there are enduring reasons why students choose to major in public relations. Public relations is described as a major that allows for and encourages creative expression and that…

  15. Mechanical and Chemical Signaling in Angiogenesis

    CERN Document Server

    2013-01-01

    This volume of Studies in Mechanobiology, Tissue Engineering and Biomaterials describes the most recent advances in angiogenesis research at all biological length scales: molecular, cellular and tissue, in both in vivo and in vitro settings.  Angiogenesis experts from diverse fields including engineering, cell and developmental biology, and chemistry have contributed chapters which focus on the mechanical and chemical signals which affect and promote blood vessel growth. Specific emphasis is given to novel methodologies and biomaterials that have been developed and applied to angiogenesis research. 

  16. Ontology-based automatic identification of public health-related Turkish tweets.

    Science.gov (United States)

    Küçük, Emine Ela; Yapar, Kürşad; Küçük, Dilek; Küçük, Doğan

    2017-02-04

    Social media analysis, such as the analysis of tweets, is a promising research topic for tracking public health concerns including epidemics. In this paper, we present an ontology-based approach to automatically identify public health-related Turkish tweets. The system is based on a public health ontology that we have constructed through a semi-automated procedure. The ontology concepts are expanded through a linguistically motivated relaxation scheme as the last stage of ontology development, before being integrated into our system to increase its coverage. The ultimate lexical resource which includes the terms corresponding to the ontology concepts is used to filter the Twitter stream so that a plausible tweet subset, including mostly public-health related tweets, can be obtained. Experiments are carried out on two million genuine tweets and promising precision rates are obtained. Also implemented within the course of the current study is a Web-based interface, to track the results of this identification system, to be used by the related public health staff. Hence, the current social media analysis study has both technical and practical contributions to the significant domain of public health.

  17. Scientists and public involvement: a consultation on the relation between malaria, vector control and transgenic mosquitoes.

    Science.gov (United States)

    Boëte, Christophe

    2011-12-01

    Among the hopes for vector-based malaria control, the use of transgenic mosquitoes able to kill malaria parasites is seen as a potential way to interrupt malaria transmission. While this potential solution is gaining some support, the ethical and social aspects related to this high-tech method remain largely unexplored and underestimated. Related to those latter points, the aim of the present survey is to determine how scientists working on malaria and its vector mosquitoes perceive public opinion and how they evaluate public consultations on their research. This study has been performed through a questionnaire addressing questions related to the type of research, the location, the nationality and the perception of the public involvement by scientists. The results suggest that even if malaria researchers agree to interact with a non-scientific audience, they (especially the ones from the global North) remain quite reluctant to have their research project submitted in a jargon-free version to the evaluation and the prior-agreement by a group of non-specialists. The study, by interrogating the links between the scientific community and the public from the perspective of the scientists, reveals the importance of fostering structures and processes that could lead to a better involvement of a non specialist public in the actual debates linking scientific, technological and public health issues in Africa.

  18. On the interdisciplinary nature of water-related programs in American public universities

    Science.gov (United States)

    Li, F.; Du, C. L.

    2017-01-01

    This paper presents a research on the interdisciplinary nature of 167 water-related programs in 46 selected American public universities. Using keyword coding and Classification method, and the results show that water-related disciplines largely focus on environment, natural resources, engineering, ocean and agricultural studies, which are all applied disciplines. Moreover, water-related disciplines lay great emphasis on the interdisciplinary research and research platforms construction with the research fields of environment, natural resources and agricultural.

  19. LPS induces HUVEC angiogenesis in vitro through miR-146a-mediated TGF-β1 inhibition

    Science.gov (United States)

    Li, Yize; Zhu, Huayu; Wei, Xu; Li, Heng; Yu, Zhicao; Zhang, Hongmei; Liu, Wenchao

    2017-01-01

    Angiogenesis is an essential process for tissue growth and embryo development. However, inflammation, abnormal wound healing, vascular diseases, and tumor development and progression can result from inappropriate angiogenesis. Lipopolysaccharide (LPS) can activate various cells and alter endothelium function and angiogenesis. This study investigated the underlying molecular events involved in LPS-induced angiogenesis and revealed a novel strategy for controlling abnormal angiogenesis. LPS treatment promoted wound healing and tube formation in human umbilical vein endothelial cell (HUVEC) cultures and induced their expression of miR-146a. miR-146a was previously shown to regulate angiogenesis in HUVECs. Knockdown of miR-146a expression antagonized LPS-induced angiogenesis in vitro. Moreover, bioinformatic analyses predicted TGF-β1 as a target gene for miR-146a, which was confirmed by aluciferase reporter assay. Expression of miR-146a in HUVECs resulted in downregulation of TGF-β1 in HUVECs, whereas a miR-146a inhibitor upregulated the expression of TGF-β1 and TGF-β1 downstream proteins, such as phosphoraylation-Smad2 and plasminogen activator inhibitor type 1 (PAI-1). Furthermore, the TGF-β1 signaling inhibitor SB431542 impaired the ability of miR-146a knockdown to suppress LPS-induced angiogenesis. Thus, LPS-induced angiogenesis of HUVECs functions through miR-146a upregulation and TGF-β1 inhibition. This study suggests that knockdown of miR-146a could activate TGF-β1 signaling to inhibit angiogenesis as a potential therapy for angiogenesis-related diseases.

  20. Notch in Pathological Angiogenesis and Lymphangiogenesis

    Science.gov (United States)

    2013-05-01

    Branching of Dopaminergic Axons. Journal of Neuroscience, 29(38): 11973-11981. BOOK CHAPTERS 1. Uh, M.K., Kandel , J., Kitajewski, J. Evaluating Tumor Angiogenesis. 2nd ed. 980. New York: Springer, 2013. 341-51. Print.

  1. Slit-Robo signaling in ocular angiogenesis.

    Science.gov (United States)

    Chen, Haoyu; Zhang, Mingzhi; Tang, Shibo; London, Nyall R; Li, Dean Y; Zhang, Kang

    2010-01-01

    Slit-Robo signaling was firstly discovered as a major repellent pathway at the midline of the central nervous system. Intense investigation found that this pathway also plays an important role in other biological process including angiogenesis. Robo4 is the vascular endothelial cell specific member of Robo family. It was found that Slit-Robo signaling can inhibit endothelial cell migration, tube formation and vascular permeability. Slit-Robo signaling also plays an important role in embryonic and tumor angiogenesis. In animal model of ocular angiogenesis, addition of Slit inhibited laser induced choroidal neovascularization, oxygen induced retinopathy and VEGF induced retinal permeability in a Robo4 dependent manner. Recent data demonstrates that Robo1 and Robo4 form a heterodimer in endothelial cells, The role of this heterodimer in counteracting VEGF signaling is unknown. Further investigation is required to better understand Slit-Robo signaling and develop novel therapy for angiogenesis.

  2. Aberrant angiogenesis: The gateway to diabetic complications

    Directory of Open Access Journals (Sweden)

    Sunil K Kota

    2012-01-01

    Full Text Available Diabetes Mellitus is a metabolic cum vascular syndrome with resultant abnormalities in both micro- and macrovasculature. The adverse long-term effects of diabetes mellitus have been described to involve many organ systems. Apart from hyperglycemia, abnormalities of angiogenesis may cause or contribute toward many of the clinical manifestations of diabetes. These are implicated in the pathogenesis of vascular abnormalities of the retina, kidneys, and fetus, impaired wound healing, increased risk of rejection of transplanted organs, and impaired formation of coronary collaterals. A perplexing feature of the aberrant angiogenesis is that excessive and insufficient angiogenesis can occur in different organs in the same individual. The current article hereby reviews the molecular mechanisms including abnormalities in growth factors, cytokines, and metabolic derangements, clinical implications, and therapeutic options of dealing with abnormal angiogenesis in diabetes.

  3. Galectins in angiogenesis: consequences for gestation.

    Science.gov (United States)

    Blois, Sandra M; Conrad, Melanie L; Freitag, Nancy; Barrientos, Gabriela

    2015-04-01

    Members of the galectin family have been shown to exert several roles in the context of reproduction. They contribute to placentation, maternal immune regulation and facilitate angiogenesis encompassing decidualisation and placenta formation during pregnancy. In the context of neo-vascularisation, galectins have been shown to augment signalling pathways that lead to endothelial cell activation, cell proliferation, migration and tube formation in vitro in addition to angiogenesis in vivo. Angiogenesis during gestation ensures not only proper foetal growth and development, but also maternal health. Consequently, restriction of placental blood flow has major consequences for both foetus and mother, leading to pregnancy diseases. In this review we summarise both the established and the emerging roles of galectin in angiogenesis and discuss the possible implications during healthy and pathological gestation.

  4. Therapeutic Angiogenesis for Treating Cardiovascular Diseases

    Directory of Open Access Journals (Sweden)

    Lorenzo Deveza, Jeffrey Choi, Fan Yang

    2012-01-01

    Full Text Available Cardiovascular disease is the leading cause of death worldwide and is often associated with partial or full occlusion of the blood vessel network in the affected organs. Restoring blood supply is critical for the successful treatment of cardiovascular diseases. Therapeutic angiogenesis provides a valuable tool for treating cardiovascular diseases by stimulating the growth of new blood vessels from pre-existing vessels. In this review, we discuss strategies developed for therapeutic angiogenesis using single or combinations of biological signals, cells and polymeric biomaterials. Compared to direct delivery of growth factors or cells alone, polymeric biomaterials provide a three-dimensional drug-releasing depot that is capable of facilitating temporally and spatially controlled release. Biomimetic signals can also be incorporated into polymeric scaffolds to allow environmentally-responsive or cell-triggered release of biological signals for targeted angiogenesis. Recent progress in exploiting genetically engineered stem cells and endogenous cell homing mechanisms for therapeutic angiogenesis is also discussed.

  5. Semaphorin signaling in angiogenesis, lymphangiogenesis and cancer

    Institute of Scientific and Technical Information of China (English)

    Atsuko Sakurai; Colleen Doci; J Silvio Gutkind

    2012-01-01

    Angiogenesis,the formation of new blood vessels from preexisting vasculature,is essential for many physiological processes,and aberrant angiogenesis contributes to some of the most prevalent human diseases,including cancer.Angiogenesis is controlled by delicate balance between pro- and anti-angiogenic signals.While pro-angiogenic signaling has been extensively investigated,how developmentally regulated,naturally occurring anti-angiogenic molecules prevent the excessive growth of vascular and lymphatic vessels is still poorly understood.In this review,we summarize the current knowledge on how semaphorins and their receptors,plexins and neuropilins,control normal and pathological angiogenesis,with an emphasis on semaphorin-regulated anti-angiogenic signaling circuitries in vascular and lymphatic endothelial cells.This emerging body of information may afford the opportunity to develop novel anti-angiogenic therapeutic strategies.

  6. Public Relation and Marketing%公共关系与市场营销

    Institute of Scientific and Technical Information of China (English)

    付丽青

    2001-01-01

    公共关系学与市场营销学是两门分别独立的学科,两者活动既有区别又有相同处,且公共关系活动在市场营销中发挥着独特的作用。%Public Relations and Marketing are two independant subjects, which not only share similarities but also show differences in some way. And Public Relation activity Plays a districtive role in marketing

  7. Strategies and techniques of communication and public relations applied to non-profit sector

    Directory of Open Access Journals (Sweden)

    Ioana – Julieta Josan

    2010-05-01

    Full Text Available The aim of this paper is to summarize the strategies and techniques of communication and public relations applied to non-profit sector.The approach of the paper is to identify the most appropriate strategies and techniques that non-profit sector can use to accomplish its objectives, to highlight specific differences between the strategies and techniques of the profit and non-profit sectors and to identify potential communication and public relations actions in order to increase visibility among target audience, create brand awareness and to change into positive brand sentiment the target perception about the non-profit sector.

  8. FROM PUBLIC RELATIONS TO THE NEW CONCEPTS OF COMMUNICATION: TERMINOLOGICAL PROBLEMS

    Directory of Open Access Journals (Sweden)

    María Isabel Míguez González

    2013-11-01

    Full Text Available The terms public relations, communication management, corporate communication, institutional communication, business communication and organizational communication coexist in the professional field of communication without clear conceptual limits. In order to clarify this situation from an academic point of view, we reviewed the contributions about these terms made by Spanish authors, based on the oldest notion of public relations. The analysis shows significant discrepancies between different authors, who can not clearly define the scope of these concepts and their relationship to each other.

  9. SPREADING THE IDEAL OF MASS SHAREOWNERSHIP: PUBLIC RELATIONS AND THE NYSE

    Directory of Open Access Journals (Sweden)

    Janice Traflet (ed.

    2004-01-01

    Full Text Available In the 1950s, the New York Stock Exchange, led by President Keith Funston, embarked on an ambitious public relations campaign christened “Own Your Share of American Business.” This paper justaposes the “Own Your Share”campaign with earlier NYSE image-making efforts. Tracing the evolution in Exchange public relations sheds lights on how the Big Board gradually embraced mass shareownership as a worthy goal and endorsed mass merchandising as a legitimate way to achieve it.

  10. Merging public relations with health communication in the context of university alcohol prevention.

    Science.gov (United States)

    Brummette, John

    2015-01-01

    The scope of this study is to determine whether social norms marketing should be further evaluated according to its ability to serve as a public relations tactic for universities. Based on a framework of social norms theory and strategic issues management, this study uses a web-based survey with university parents (N = 173) to identify relationships among exaggerated parental misperceptions of student binge drinking, parental awareness of alcohol prevention programs, and parental perceptions of organizational legitimacy. Findings from this study are used to make the argument that health communication and public relations should be viewed as interrelated concepts in the context of university alcohol prevention.

  11. Duplicate publications and related problems in published papers on oral and maxillofacial surgery.

    Science.gov (United States)

    Le, A; Moran, C M P; Bezuhly, M; Hong, P

    2015-07-01

    As duplicate publication is unethical, our aim was to find out how common it is among published papers on oral and maxillofacial surgery. We used PubMed to identify index articles published in 2010 in the Journal of Oral and Maxillofacial Surgery, the British Journal of Oral and Maxillofacial Surgery, and the European Journal of Cranio-Maxillo-Facial Surgery, and searched for possible duplicate publications from 2008 to 2012 using the first or second and last authors' names. Suspected duplicates were categorised into "non-duplicate" (no overlap), "duplicate" (identical results and conclusions), or "salami-sliced" publications (part of the index article repeated or continued). Of the 589 index articles, 17 (3%) had some form of duplication, but specifically, we found 3 duplicate, and 15 salami-sliced publications. Most redundant articles originated from China (n=4), followed by Italy, Japan, and Germany (3 from each) and the United States and Denmark (2 each). Of the 18 redundant publications, 9 did not reference the related index article. Duplicate material is still being published, and salami-slicing is relatively common among publications on oral and maxillofacial surgery. Further research is required into the extent and impact of this finding.

  12. Use of a consultant to assist a dietetic association in its media and public relations efforts.

    Science.gov (United States)

    Visocan, B J; Lazin, B

    1989-04-01

    During 1987, the Philadelphia Dietetic Association (PDA) enlisted the aid of a public relations consultant to increase media contacts and thereby accomplish a threefold goal of (a) establishing the dietetic association and its registered dietitian members as the local nutrition experts; (b) distributing reliable, current nutrition information; and (c) marketing the PDA's DIAL-A-DIETITIAN service. Through the advice of the consultant, a media tipsheet, published monthly, was created. This publication, the Nutrition Informationist, effectively increased media contacts from two in 1986 to 19 in 1987 and resulted in a total of 8 hours of air time. Weight reduction, fad diets, and sports nutrition proved to be the most popular topics. Public service announcements (PSAs) concerning the DIAL-A-DIETITIAN program were developed by the consultant to assist the public in gaining access to local registered dietitians. Calls to that service increased 75% (from an average of 47.5 to 83.0 calls) the month following the distribution of PSAs to radio stations. The positive outcome of this collaborative effort shows that public relations consultants can be a useful resource for local dietetic associations, aiding them in their efforts to reach the media and the public and to improve their image.

  13. Awareness, attitudes, and practices related to the swine influenza pandemic among the Saudi public

    Directory of Open Access Journals (Sweden)

    Al-Jumah Mohammad A

    2010-02-01

    Full Text Available Abstract Background During an infectious disease outbreak, it is critical to learn as much as possible about the concerns, knowledge, attitudes, and behavior of the public. Such information can be crucial to the improvement of communication efforts by public health officials and clinicians. The aim of this study was to identify awareness, attitudes, and practices related to influenza A (H1N1 among the Saudi public. Methods A cross-sectional study of 1,548 adult subjects recruited from various shopping malls in Riyadh and Jeddah was conducted. All of the subjects were interviewed using a questionnaire that tested their knowledge, attitudes, and use of precautionary measures in relation to the H1N1 influenza pandemic. Results More than half (54.3%, 840/1548 of the participants showed high concern, 43.7%(677/1548 showed a low level of knowledge, and 60.8%(941/1548 had taken minimal or no precautionary measures. After adjusting for other variables, education level was the only significant predictor of the level of concern (p Conclusions High concern did not translate into a higher compliance with precautionary recommendations, possibly due to the low level of knowledge about the disease among the public. Frequent communication between physicians and the public is recommended to help dispel myths about the disease and to spread better information about the role that the public can play in limiting the spread of the disease.

  14. MACRO-PUBLIC RELATIONS: CRISIS COMMUNICATION IN THE AGE OF INTERNET

    Directory of Open Access Journals (Sweden)

    Zhongxuan Lin

    2013-12-01

    Full Text Available In order to study the crisis communication in the age of Internet, the study takes the battle between two Internet companies, Tencent and Qihoo, as a case study, but focuses more on their huge public audiences, which may be defined as a “macro-public” crowd. The study employs multiple research methods including survey, focus groups interviews and content analysis to explore their “macro-public relations” which may be driven by the spiral of silence and crowd psychology. This dynamic underground power is the reason that two companies employed similar public relations strategies in crisis communication but the results of the crisis were different. The study attempts to contribute to the knowledge base by defining and highlighting the power and function of “macro-public relations” for crisis communication in the age of Internet.

  15. Neomycin inhibits angiogenin-induced angiogenesis

    OpenAIRE

    1998-01-01

    A class of angiogenesis inhibitor has emerged from our mechanistic study of the action of angiogenin, a potent angiogenic factor. Neomycin, an aminoglycoside antibiotic, inhibits nuclear translocation of human angiogenin in human endothelial cells, an essential step for angiogenin-induced angiogenesis. The phospholipase C-inhibiting activity of neomycin appears to be involved, because U-73122, another phospholipase C inhibitor, has a similar effect. In contrast, genistein, oxophenylarsine, an...

  16. Piperine, a dietary phytochemical, inhibits angiogenesis

    OpenAIRE

    2012-01-01

    Angiogenesis plays an important role in tumor progression. Piperine, a major alkaloid constituent of black pepper, has diverse physiological actions including killing of cancer cells; however, the effect of piperine on angiogenesis is not known. Here we show that piperine inhibited the proliferation and G1/S transition of human umbilical vein endothelial cells (HUVECs) without causing cell death. Piperine also inhibited HUVEC migration and tubule formation in vitro, as well as collagen-induce...

  17. Strategic Factors in the Choice of a Model of Public Relations. Case Study: Seventh-day Adventist Church World Headquarters.

    Science.gov (United States)

    Denton, Holly M.

    A study tested a model of organizational variables that earlier research had identified as important in influencing what model(s) of public relations an organization selects. Models of public relations (as outlined by J. Grunig and Hunt in 1984) are defined as either press agentry, public information, two-way asymmetrical, or two-way symmetrical.…

  18. Right Relation and Right Recognition in Public Health Ethics: Thinking Through the Republic of Health.

    Science.gov (United States)

    Jennings, Bruce

    2016-07-01

    The further development of public health ethics will be assisted by a more direct engagement with political theory. In this way, the moral vocabulary of the liberal tradition should be supplemented-but not supplanted-by different conceptual and normative resources available from other traditions of political and social thought. This article discusses four lines of further development that the normative conceptual discourse of public health ethics might take. (i) The relational turn. The implications for public health ethics of the new 'ecological' or 'relational' interpretation that is emerging for concepts such as agency, self-identity, autonomy, liberty and justice. (ii) Governing the health commons. The framework of collective action problems is giving way to notions of democratic governance and management of common resources. (iii) The concept of membership. Membership is specified by the notions of equal respect and parity of voice and agency. (iv) The concept of mutuality. Mutuality is specified by the notions of interdependent concern and care.

  19. Children's evaluation of public and private generosity and its relation to behavior: Evidence from China.

    Science.gov (United States)

    Heyman, Gail D; Fu, Genyue; Barner, David; Zhishan, Hu; Zhou, Lixia; Lee, Kang

    2016-10-01

    This research examined children's evaluation of public and private prosocial giving and whether such evaluation would predict actual behavior. We tested children between 6 and 12 years old (N=192) in China, where children are socialized not to call positive attention to themselves. In Study 1, a significant age-related change was found; younger children evaluated public acts of prosocial giving more favorably than private acts, whereas older children showed the opposite pattern. Study 2 not only replicated the findings of Study 1 but also showed that children's evaluation of public versus private giving predicted their actual behavior in communicating about their own prosocial giving. These findings are the first to show that age-related changes in children's understanding of generosity predict reputation management behavior.

  20. Clustering scientific publications based on citation relations: A systematic comparison of different methods

    CERN Document Server

    Šubelj, Lovro; Waltman, Ludo

    2015-01-01

    Clustering methods are applied regularly in the bibliometric literature to identify research areas or scientific fields. These methods are for instance used to group publications into clusters based on their relations in a citation network. In the network science literature, many clustering methods, often referred to as graph partitioning or community detection techniques, have been developed. Focusing on the problem of clustering the publications in a citation network, we present a systematic comparison of the performance of a large number of these clustering methods. Using a number of different citation networks, some of them relatively small and others very large, we extensively study the statistical properties of the results provided by different methods. In addition, we also carry out an expert-based assessment of the results produced by different methods. The expert-based assessment focuses on publications in the field of scientometrics. Our findings seem to indicate that there is a trade-off between di...

  1. Studies on tumor induced angiogenesis.

    Science.gov (United States)

    Ambrus, J L; Ambrus, C M; Forgach, P; Stadler, S; Halpern, J; Sayyid, S; Niswander, P; Toumbis, C

    1992-01-01

    Methods were developed to test angiogenic response to human tumor implants and various biologic agents in the cornea of rabbits and non-human primates (Macaca arctoides). Crude PDGF preparations were found to have significant angiogenic effect. Purified, recombinant PDGF preparations were also effective inhibitors (e.g. pentoxifylline (Px) (which also were found to release PgI2 and t-PA) inhibited human tumor implant induced angiogenesis and reduced spontaneous metastases in 3 transplantable murine tumors (Furth-Columbia Wilms' tumor in Furth-Wistar rats, C-1300 neuroblastoma in A/J mice and HM-Kim mammary carcinoma in Wistar rats) but not in the NIH adenocarcinoma in Balb/c mice. Sodium diethyldithiocarbamate (DDTC), a metal complexing agent with special affinity to copper and anti-thyroid as well as, immune stimulating activity was shown to be anti-angiogenic and to potentiate the effect of Px. The anti-fibrinolytic agents epsilon amino caproic acid (EACA) and tranaxamic acid (t-AMCHA) were anti-angiogenic. DDTC and Px were synergistic from this point of view.

  2. Effects of Message Interactivity upon Relational Maintenance Strategy in Digital Communications between Organizations and the Public

    Science.gov (United States)

    Liu, Zhan-Qing

    2012-01-01

    Digital communication between organizations and the public is strategically important in shaping mutual understanding and long term relationship. The primary focus of this project was to investigate the relationship between message interactivity and relational maintenance strategy in the email communication process on organization websites. At…

  3. Preparing Public Relations and Advertising Students for the 21st Century: A Case Study.

    Science.gov (United States)

    Carroll, Robert A.

    In 1993, the Task Force on Integrated Communications reported that public relations and advertising students would better be prepared to enter a changing communications industry through an "integrated" curriculum. This paper is a case study of how one university has attempted to meet that challenge. The work has resulted in the development of an…

  4. 77 FR 12853 - Draft Guidances Relating to the Development of Biosimilar Products; Public Hearing; Request for...

    Science.gov (United States)

    2012-03-02

    ... biosimilar product development. We agree with this approach and have begun with the three draft guidance... HUMAN SERVICES Food and Drug Administration Draft Guidances Relating to the Development of Biosimilar Products; Public Hearing; Request for Comments AGENCY: Food and Drug Administration, HHS. ACTION: Notice...

  5. The Rhetoric of Arrogance: The Public Relations Response of the Standard Oil Trust.

    Science.gov (United States)

    Boyd, Josh

    2001-01-01

    Illustrates one of the earliest American public relations debacles (ending in the dissolution of the Standard Oil Trust in 1911). Presents background on Standard Oil and offers an overview Ida Tarbell's influential "History of the Standard Oil company." Argues that Standard failed to respond to these accounts adequately, reinforcing…

  6. 78 FR 38713 - Additional Documents Available for Public Review Related to Willingness To Pay Survey for...

    Science.gov (United States)

    2013-06-27

    ... revised Supporting Statement, the Peer Review Report, the Focus Group and Cognitive Interview Report and... Review Report, the Focus Group and Cognitive Interview Report and the Description of Hydrological... AGENCY Additional Documents Available for Public Review Related to Willingness To Pay Survey...

  7. The role and importance of public relations at non-governmental organizations

    Directory of Open Access Journals (Sweden)

    Simona Duhalm

    2010-12-01

    Full Text Available Phenomenon of globalization during the twentieth century, has increased the importance of nongovernmental organizations. Their development has gained to the whole world providing an important part of social, educational, cultural and welfare services that the community felt. Voluntary and non-profit activity which it carries led, implicitly, to increasing importance in public relations sector, compared with profit business.

  8. Ethical Values, the Flow of Journalistic Information and Public Relations Persons.

    Science.gov (United States)

    Ryan, Michael; Martinson, David L.

    1984-01-01

    Reports on a study that found that public relations practitioners respond in different ways to different moral-ethical dilemmas and that they tend to think they are accountable in some situations to an authority higher than management. Concludes that subjectivism is the prevailing moral-ethical theory of practitioners. (FL)

  9. How European public relations men and women perceive the impact of their professional activities

    NARCIS (Netherlands)

    Verhoeven, P.; Aarts, N.

    2010-01-01

    Starting from the theoretical perspective of gendered discourses, a secondary analysis of the data from the European Communication Monitors of 2008 and 2009, an annual survey about trends in the profession of public relations, was conducted on gender differences. The pilot study shows that female pu

  10. Key issues of public relations of Europe: findings from the European Communication Monitor 2007-2014

    NARCIS (Netherlands)

    Verčič, D.; Verhoeven, P.; Zerfass, A.

    2014-01-01

    European Communication Monitor is the largest longitudinal research project in public relations practice in the world. Data collected annually from 2007 to 2014 show that practitioners perceive five issues as the most important for their work: linking business strategy and communication, coping with

  11. Gender Differences in Public Relations Students' Career Attitudes: A Benchmark Study.

    Science.gov (United States)

    Farmer, Betty; Waugh, Lisa

    1999-01-01

    Explores students' perceptions of gender issues in public relations. Finds that there were no statistically significant differences in male and female students' desires to perform managerial activities, but there were statistically significant differences in several areas (i.e. female students expect to earn less money starting out and to be…

  12. Advertising or public relations – which is the organizations choice in the current period?

    Directory of Open Access Journals (Sweden)

    Simona Duhalm

    2009-12-01

    Full Text Available In the current period, when the issue of efficient use of financial resources is a central, organizations seeking the best ways to both promote their self-image, and products or services they produce and sell. Between the promotional techniques by the mass communication in which organizations can appeal, the makers have to choose between advertising and public relations activities.

  13. Teaching Public Relations Management: Bringing "The Ideal" and "The Real" Closer Together.

    Science.gov (United States)

    Turk, Judy VanSlyke; Russell, Maria P.

    A study examined the technical versus managerial roles of public relations practitioners. The study investigated what it takes to be a manager, what skills and perspectives are needed by entry-level practitioners as they climb the ladder, and what actions educators should take to ensure that students learn the critical skills. Three hundred…

  14. 77 FR 3794 - Certain Mobile Devices and Related Software; Request for Statements on the Public Interest

    Science.gov (United States)

    2012-01-25

    ... From the Federal Register Online via the Government Publishing Office INTERNATIONAL TRADE COMMISSION Certain Mobile Devices and Related Software; Request for Statements on the Public Interest AGENCY: U.S. International Trade Commission. ACTION: Notice. SUMMARY: Notice is hereby given that...

  15. Discipline as a Source of Public Relations in a Christian School

    Science.gov (United States)

    Simmons, Brian S.

    2004-01-01

    Christian schools, like all private schools, face the challenge of building and maintaining the confidence of parents and other stakeholders. Their public relations efforts should be rooted in institutional mission and core values, factors that influence parents to elect this educational option. Administrators and others often overlook the fact…

  16. Students' Expectations and Motivation for Service-Learning in Public Relations

    Science.gov (United States)

    Muturi, Nancy; An, Soontae; Mwangi, Samuel

    2013-01-01

    This study is based on a survey of public relations students and examines their attitudes, expectations, and motivations for participating in curriculum-infused service-learning projects. Results indicate that prior participation does not influence attitudes or expectations, but motivation to participate in the project was significantly associated…

  17. A Countrywide Study on Factors Influencing the Public Relations Practice in Higher Education in Taiwan

    Science.gov (United States)

    Yang, Mu-Li; Chiou, Wen-Bin

    2010-01-01

    This countrywide study was conducted to determine what organizational and individual factors have a significant impact on the performance of public relations (PR) practice in higher educational institutions in Taiwan. In this study, a purposive sampling of 600 administrative staff whose jobs involved university PR was employed, and 301 effective…

  18. Integrating Service Learning into Public Relations Coursework: Applications, Implications, Challenges, and Rewards

    Science.gov (United States)

    Gleason, James P.; Violette, Jayne L.

    2012-01-01

    Drawing on a theoretical framework based on "use-inspired" applied research and service learning practice (Honnet-Porter & Poulsen, 1989), this paper argues the relationship between a service-learning approach and Public Relations coursework is a natural and highly desirable fit. Through examination of the goals of both service-learning and public…

  19. Building the Case for Educating Business Leaders on the Importance of Public Relations

    Science.gov (United States)

    Hagan, Linda M.

    2011-01-01

    An organization's well-developed strategic plan and reputation can crumble in minutes if it mishandles key communications, particularly during crises. Today's leaders need to appreciate the value of professional public relations and how it helps organizational effectiveness by building strategic relationships, maintaining a favorable reputation,…

  20. Think Bubbles and Socrates: Teaching Critical Thinking to Millennials in Public Relations Classes

    Science.gov (United States)

    Tallent, Rebecca J.; Barnes, Justin J.

    2015-01-01

    Critical thinking skills are crucial in the public relations profession, but teaching these skills to the Millennial Generation is vastly different from previous generations. How can a professor get past No Child Left Behind's dependence on test review guides and "everybody wins" in getting students to think for themselves? Using the…

  1. Through Classroom Walls: A Collaborative Public Relations Education for Creating Integrated, Digital Media Campaigns

    Science.gov (United States)

    Geyer-Semple, Victoria

    2012-01-01

    Public relations (PR) educators and professionals often encounter strife of managing the need of teaching research, writing and critical thinking skills in the classroom. In addition, educators are also tending to the needs of implementing current industry trends into the undergraduate curriculum. In today's undergraduate PR programs significant…

  2. 4-Hydroxy-7-oxo-5-heptenoic Acid Lactone Induces Angiogenesis through Several Different Molecular Pathways.

    Science.gov (United States)

    Guo, Junhong; Linetsky, Mikhail; Yu, Annabelle O; Zhang, Liang; Howell, Scott J; Folkwein, Heather J; Wang, Hua; Salomon, Robert G

    2016-12-19

    Oxidative stress and angiogenesis have been implicated not only in normal phenomena such as tissue healing and remodeling but also in many pathological processes. However, the relationships between oxidative stress and angiogenesis still remain unclear, although oxidative stress has been convincingly demonstrated to influence the progression of angiogenesis under physiological and pathological conditions. The retina is particularly susceptible to oxidative stress because of its intensive oxygenation and high abundance of polyunsaturated fatty acyls. In particular, it has high levels of docosahexanoates, whose oxidative fragmentation produces 4-hydroxy-7-oxo-5-heptenoic acid lactone (HOHA-lactone). Previously, we found that HOHA-lactone is a major precursor of 2-(ω-carboxyethyl)pyrrole (CEP) derivatives, which are tightly linked to age-related macular degeneration (AMD). CEPs promote the pathological angiogenesis of late-stage AMD. We now report additional mechanisms by which HOHA-lactone promotes angiogenesis. Using cultured ARPE-19 cells, we observed that HOHA-lactone induces secretion of vascular endothelial growth factor (VEGF), which is correlated to increases in reactive oxygen species and decreases in intracellular glutathione (GSH). Wound healing and tube formation assays provided, for the first time, in vitro evidence that HOHA-lactone induces the release of VEGF from ARPE-19 cells, which promotes angiogenesis by human umbilical vein endothelial cells (HUVEC) in culture. Thus, HOHA-lactone can stimulate vascular growth through a VEGF-dependent pathway. In addition, results from MTT and wound healing assays as well as tube formation experiments showed that GSH-conjugated metabolites of HOHA-lactone stimulate HUVEC proliferation and promote angiogenesis in vitro. Previous studies demonstrated that HOHA-lactone, through its CEP derivatives, promotes angiogenesis in a novel Toll-like receptor 2-dependent manner that is independent of the VEGF receptor or VEGF

  3. Oridonin inhibits tumor growth and metastasis through anti-angiogenesis by blocking the Notch signaling.

    Directory of Open Access Journals (Sweden)

    Yanmin Dong

    Full Text Available While significant progress has been made in understanding the anti-inflammatory and anti-proliferative effects of the natural diterpenoid component Oridonin on tumor cells, little is known about its effect on tumor angiogenesis or metastasis and on the underlying molecular mechanisms. In this study, Oridonin significantly suppressed human umbilical vascular endothelial cells (HUVECs proliferation, migration, and apillary-like structure formation in vitro. Using aortic ring assay and mouse corneal angiogenesis model, we found that Oridonin inhibited angiogenesis ex vivo and in vivo. In our animal experiments, Oridonin impeded tumor growth and metastasis. Immunohistochemistry analysis further revealed that the expression of CD31 and vWF protein in xenografts was remarkably decreased by the Oridonin. Furthermore, Oridonin reinforced endothelial cell-cell junction and impaired breast cancer cell transendothelial migration. Mechanistically, Oridonin not only down-regulated Jagged2 expression and Notch1 activity but also decreased the expression of their target genes. In conclusion, our results demonstrated an original role of Oridonin in inhibiting tumor angiogenesis and propose a mechanism. This study also provides new evidence supporting the central role of Notch in tumor angiogenesis and suggests that Oridonin could be a potential drug candidate for angiogenesis related diseases.

  4. Mechanism of Arsenic Trioxide Inhibiting Angiogenesis in Multiple Myeloma

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    In order to explore the molecular mechanism of arsenic trioxide treating multiple myeloma (MM) via inhibition of angiogenesis, the expression of brain derived neurotrophic factor (BD-NF) and its specific receptor TrkB in human MM cell line KM3 and endothelial cell line ECV304 was detected by Western blotting. The angiogenic activity was evaluated by wound migration assay and tubule formation assay in vitro. The results showed that BDNF was detected in the MM cells and TrkB in the endothelial cells. Furthermore, 100 ng/mL BDNF could significantly induced endo thelial cell tubule formation and wound migration. As2 O3 depressed the expression of BDNF and TrkB in the dose- and time-dependent manner. As2O3 inhibited BDNF-induced wound migration and capillary tube formation. It was concluded that BDNF is a novel angiogenic protein as well as VEGF and has a relation with the pathogenesis of MM. As2O3 interrupts a paracrine loop between MM cells and endothelial cells by down-regulating the TrkB expression in endothelial cells and inhibiting BDNF production in MM cells, finally resulting in inhibition of MM angiogenesis. This is probably one part of the mechanisms of the As2O3 treating MM via the inhibition of angiogenesis.

  5. Molecular mechanisms linking thrombosis and angiogenesis in cancer.

    Science.gov (United States)

    Shoji, M; Abe, K; Nawroth, P P; Rickles, F R

    1997-02-01

    In this brief review, the authors concentrate on selected issues related to the newly described role of tissue factor (TF), the major activator of mammalian blood coagulation, as a regulator of angiogenesis and of tumor growth and metastasis. Previously, TF had been considered strictly as the primary activator of the coagulation cascade; however, it has recently been demonstrated that overexpression of the TF gene in murine tumor cells leads to increased transcription of the gene for vascular permeability factor/vascular endothelial growth factor (VEGF), a proangiogenic factor, and decreased transcription of the gene for thrombospondin (TSP), an antiangiogenic factor. Conversely, underexpression of TF leads to decreased VEGF and increased TSP transcription. When grown in mice and compared with low TF-producing tumor cells, high TF-producing tumor cells stimulate angiogenesis by approximately twofold. This effect of TF appears to be independent of its clot-promoting procoagulant activity (PCA) and suggests that TF regulates the angiogenic properties of tumor cells by altering the production of growth regulatory molecules (for example, VEGF) that can act on vascular endothelial cells (VECs). There is substantial preliminary evidence that the regulation of tumor angiogenesis can be mediated by TF via both fibrin clotting-dependent and fibrin clotting-independent mechanisms. (Trends Cardiovasc Med 1997;7:52-59). © 1997, Elsevier Science Inc.

  6. Lipocalin-7 is a matricellular regulator of angiogenesis.

    Directory of Open Access Journals (Sweden)

    Leslie J Brown

    Full Text Available BACKGROUND: Matricellular proteins are extracellular regulators of cellular adhesion, signaling and performing a variety of physiological behaviors such as proliferation, migration and differentiation. Within vascular microenvironments, matricellular proteins exert both positive and negative regulatory cues to vascular endothelium. The relative balance of these matricellular cues is believed to be critical for vascular homeostasis, angiogenesis activation or angiogenesis resolution. However, our knowledge of matricellular proteins within vascular microenvironments and the mechanisms by which these proteins impact vascular function remain largely undefined. The matricellular protein lipocalin-7 (LCN7 is found throughout vascular microenvironments, and circumstantial evidence suggests that LCN7 may be an important regulator of angiogenesis. Therefore, we hypothesized that LCN7 may be an important regulator of vascular function. METHODOLOGY AND PRINCIPAL FINDINGS: To test this hypothesis, we examined the effect of LCN7 overexpression, recombinant protein and gene knockdown in a series of in vitro and in vivo models of angiogenesis. We found that overexpression of LCN7 in MB114 and SVEC murine endothelial cell lines or administration of highly purified recombinant LCN7 protein increased endothelial cell invasion. Similarly, LCN7 increased angiogenic sprouting from quiescent endothelial cell monolayers and ex vivo aortic rings. Moreover, LCN7 increased endothelial cell sensitivity to TGF-β but did not affect sensitivity to other pro-angiogenic growth factors including bFGF and VEGF. Finally, morpholino based knockdown of LCN7 in zebrafish embryos specifically inhibited angiogenic sprouting but did not affect vasculogenesis within injected embryos. CONCLUSIONS AND SIGNIFICANCE: No functional analysis has previously been performed to elucidate the function of LCN7 in vascular or other cellular processes. Collectively, our results show for the first

  7. GENDER RELATIONS AND POWER: A STUDY WITH MANAGERS-PROFESSORS AT A PUBLIC UNIVERSITY

    Directory of Open Access Journals (Sweden)

    Adílio Renê Almeida Miranda

    2015-04-01

    Full Text Available This study aimed to understand how power relations are manifested daily in women who are professors and managers – managers-professors – of a public university. We used a qualitative approach and the method of life story. The subjects of the research were five women who occupied/occupy management positions at a public university. Among the difficulties faced by them, there are power asymmetries exposed in a symbolic way, cases of moral harassment, the “glass ceiling” phenomenon and the discrimination and prejudice, mainly through discourse and humor.

  8. Einstein's opponents the public controversy about the theory of relativity in the 1920s

    CERN Document Server

    Wazeck, Milena

    2014-01-01

    This detailed account of the controversy surrounding the publication of Albert Einstein's theory of relativity explores the ferocious popular and academic opposition which at one time encircled one of the most important scientific breakthroughs of the twentieth century. Based on extensive archival research, this fascinating discourse includes a compelling and entertaining examination of the contemporary literature created by Einstein's detractors. Exploring the arguments and strategies, social contexts, and motivations of Einstein's detractors, and providing unique insights into the dynamics of scientific controversies, this book is ideal for anyone interested in the history and philosophy of physics, popular science, and the public understanding of science.

  9. Index of Laser Program publications and related reports, calendar year 1984

    Energy Technology Data Exchange (ETDEWEB)

    1985-05-01

    This document provides a listing of titles and authors of publications from the LLNL Laser program during calendar year 1984. It is presented as an aid for researchers in the field who may not otherwise have access to a full listing of laser-related work done at LLNL. The intent is to provide a brief and concise listing. Publications are classified by subject, but cross references are not supplied and those documents that logically fall in more than one category may not appear to be in the obvious location.

  10. Hypoxia and Angiogenesis in Endometrioid Endometrial Carcinogenesis

    Directory of Open Access Journals (Sweden)

    Nicole Horrée

    2007-01-01

    Full Text Available Background: Hypoxia-inducible factor 1α (HIF-1α plays an essential role in the adaptive response of cells to hypoxia, triggering biologic events associated with aggressive tumor behavior. Methods: Expression of HIF-1α and proteins in the HIF-1α pathway (Glut-1, CAIX, VEGF in paraffin-embedded specimens of normal (n = 17, premalignant (n = 17 and endometrioid endometrial carcinoma (n = 39 was explored by immunohistochemistry, in relation to microvessel density (MVD. Results: HIF-1α overexpression was absent in inactive endometrium but present in hyperplasia (61% and carcinoma (87%, with increasing expression in a perinecrotic fashion pointing to underlying hypoxia. No membranous expression of Glut-1 and CAIX was noticed in inactive endometrium, in contrast with expression in hyperplasia (Glut-1 0%, CAIX 61%, only focal and diffuse and carcinoma (Glut-1 94.6%, CAIX 92%, both mostly perinecrotically. Diffuse HIF-1α was accompanied by activation of downstream targets. VEGF was significantly higher expressed in hyperplasias and carcinomas compared to inactive endometrium. MVD was higher in hyperplasias and carcinomas than in normal endometrium (p < 0.001. Conclusion: HIF-1α and its downstream genes are increasingly expressed from normal through premalignant to endometrioid adenocarcinoma of the endometrium, paralleled by activation of its downstream genes and increased angiogenesis. This underlines the potential importance of hypoxia and its key regulator HIF-1α in endometrial carcinogenesis.

  11. Cancer gene therapy targeting angiogenesis: An updated review

    Institute of Scientific and Technical Information of China (English)

    Ching-Chiu Liu; Zan Shen; Hsiang-Fu Kung; Marie CM Lin

    2006-01-01

    Since the relationship between angiogenesis and tumor growth was established by Folkman in 1971,scientists have made efforts exploring the possibilities in treating cancer by targeting angiogenesis. Inhibition of angiogenesis growth factors and administration of angiogenesis inhibitors are the basics of antiangiogenesis therapy. Transfer of anti-angiogenesis genes has Received attention recently not only because of the advancement of recombinant vectors, but also because of the localized and sustained expression of therapeutic gene product inside the tumor after gene transfer. This review provides the up-to-date information about the strategies and the vectors studied in the field of anti-angiogenesis cancer gene therapy.

  12. Angiogenesis is inhibitory for mammalian digit regeneration.

    Science.gov (United States)

    Yu, Ling; Yan, Mingquan; Simkin, Jennifer; Ketcham, Paulina D; Leininger, Eric; Han, Manjong; Muneoka, Ken

    2014-06-01

    The regenerating mouse digit tip is a unique model for investigating blastema formation and epimorphic regeneration in mammals. The blastema is characteristically avascular and we previously reported that blastema expression of a known anti-angiogenic factor gene, Pedf, correlated with a successful regenerative response (Yu, L., Han, M., Yan, M., Lee, E. C., Lee, J. & Muneoka, K. (2010). BMP signaling induces digit regeneration in neonatal mice. Development, 137, 551-559). Here we show that during regeneration Vegfa transcripts are not detected in the blastema but are expressed at the onset of differentiation. Treating the amputation wound with vascular endothelial growth factor enhances angiogenesis but inhibits regeneration. We next tested bone morphogenetic protein 9 (BMP9), another known mediator of angiogenesis, and found that BMP9 is also a potent inhibitor of digit tip regeneration. BMP9 induces Vegfa expression in the digit stump suggesting that regenerative failure is mediated by enhanced angiogenesis. Finally, we show that BMP9 inhibition of regeneration is completely rescued by treatment with pigment epithelium-derived factor. These studies show that precocious angiogenesis is inhibitory for regeneration, and provide compelling evidence that the regulation of angiogenesis is a critical factor in designing therapies aimed at stimulating mammalian regeneration.

  13. Role of anti-angiogenesis therapy in the management of hepatocellular carcinoma: The jury is still out

    Institute of Scientific and Technical Information of China (English)

    Hong; Sun; Man-Sheng; Zhu; Wen-Rui; Wu; Xiang-De; Shi; Lei-Bo; Xu

    2014-01-01

    As the leading cause of disease-related deaths,cancer is a major public health threat worldwide.Surgical resection is still the first-line therapy for patients with early-stage cancers.However,postoperative relapse and metastasis remain the cause of 90%of deaths of patients with solid organ malignancies,including hepatocellular carcinoma(HCC).With the rapid development of molecular biology techniques in recent years,molecularly targeted therapies using monoclonal antibodies,small molecules,and vaccines have become a milestone in cancer therapeutic by significantly improv-ing the survival of cancer patients,and have opened a window of hope for patients with advanced cancer.Hypervascularization is a major characteristic of HCC.It has been reported that anti-angiogenic treatments,which inhibit blood vessel formation,are highly effective for treating HCC.However,the efficacy and safety of anti-angiogenesis therapies remain controversial.Sorafenib is an oral multikinase inhibitor with antiproliferative and anti-angiogenic effects and is the first molecular target drug approved for the treatment of advanced HCC.While sorafenib has shown promising therapeutic effects,substantial evidence of primary and acquired resistance to sorafenib has been reported.Numerous clinical trials have been conducted to evaluate a large number of molecularly targeted drugs for treating HCC,but most drugs exhibited less efficacy and/or higher toxicity compared to sorafenib.Therefore,understanding the mechanism(s)underlying sorafenib resistance of cancer cells is highlighted for efficiently treating HCC.This concise review aims to provide an overview of anti-angiogenesis therapy in the management of HCC and to discuss the common mechanisms of resistance to anti-angiogenesis therapies.

  14. Researching emotional labour among Public Relations consultants in the UK: a social phenomenological approach

    Directory of Open Access Journals (Sweden)

    Liz Yeomans

    2016-05-01

    Full Text Available ‘Social phenomenology’ (Schütz, 1970; 1978 and its concept of the ‘lifeworld’ has received limited attention in the research methods literature. Few contemporary researchers, with the exception of Aspers (2006a; 2006b; 2009 and Svensson (2007 have developed procedures for undertaking social phenomenological research in occupational settings. I developed a social phenomenological approach to explore, from an emotional labour perspective, how public relations (PR consultants experienced, practised and understood their everyday interactions with clients, colleagues and journalists (Hochschild, 1983. If emotion is understood as a relational practice, the analysis of socially-constructed discourse is essential to access emotional meaning structures within occupational cultures such as public relations. I adopted an iterative analytical process whereby I interviewed, twice, a sample of six participants. From transcript analysis I produced a ‘description of practice’ document for participants to check (Aspers, 2006a; 2009. ‘Bracketing’ (Husserl, 1963/1913 involved writing self-memos throughout the research process, and finally, a self-reflexive account. Thematic analysis of findings resulted in a rich understanding of emotion management and identity work in public relations. This paper demonstrates that an iterative and reflexive analytical process that involves participants in cocreating social reality, is a compelling approach to understand the ‘lifeworld’ of social actors in occupational settings.

  15. Clustering Scientific Publications Based on Citation Relations: A Systematic Comparison of Different Methods.

    Science.gov (United States)

    Šubelj, Lovro; van Eck, Nees Jan; Waltman, Ludo

    2016-01-01

    Clustering methods are applied regularly in the bibliometric literature to identify research areas or scientific fields. These methods are for instance used to group publications into clusters based on their relations in a citation network. In the network science literature, many clustering methods, often referred to as graph partitioning or community detection techniques, have been developed. Focusing on the problem of clustering the publications in a citation network, we present a systematic comparison of the performance of a large number of these clustering methods. Using a number of different citation networks, some of them relatively small and others very large, we extensively study the statistical properties of the results provided by different methods. In addition, we also carry out an expert-based assessment of the results produced by different methods. The expert-based assessment focuses on publications in the field of scientometrics. Our findings seem to indicate that there is a trade-off between different properties that may be considered desirable for a good clustering of publications. Overall, map equation methods appear to perform best in our analysis, suggesting that these methods deserve more attention from the bibliometric community.

  16. Targeted microbubbles for imaging tumor angiogenesis: assessment of whole-body biodistribution with dynamic micro-PET in mice

    DEFF Research Database (Denmark)

    Willmann, Jürgen K; Cheng, Zhen; Davis, Corrine;

    2008-01-01

    To evaluate in vivo whole-body biodistribution of microbubbles (MBs) targeted to tumor angiogenesis-related vascular endothelial growth factor (VEGF) receptor 2 (VEGFR2) by using dynamic micro-positron emission tomography (PET) in living mice....

  17. “Open”: the changing relation between citizens, public administration, and political authority

    Directory of Open Access Journals (Sweden)

    Ursula Maier-Rabler

    2012-01-01

    Full Text Available "Open" is not just a fancy synonym for transparent and accountable. The "Open" in Open Government, Open Data, Open Information, and Open Innovation stands for the changing relation between citizens and authorities. Many citizens no longer accept the passive stance representative democracy held for them. They take an active approach in setting up better means of collaboration by ICTs. They demand and gain access to their historically grown collective knowledge stored in government data. Not just on a local level, they actively shape the political agenda. Open Government is to be seen in the context of citizens‘ rights: the right to actively participate in the process of agenda-setting and decision-making. Research into open government needs to address the value of the changing relation between citizens, public administration, and political authority. The paper argues finally for the application of the Public Value concept to research into open government.

  18. Public Relations and Religious Diversity: A Conceptual Framework for Fostering a Spirit of Communitas

    Directory of Open Access Journals (Sweden)

    Donn James Tilson

    2011-01-01

    Full Text Available Changes in immigration law, globalization and increased ease of transportation have transformed modern societies into culturally diverse landscapes with religious diversity, in particular, presenting both opportunities and challenges. The author proposes a conceptual framework that embraces an interpretation of public relations as a social function, a covenantal model as a theoretical ground, an expanded worldview to include tolerance as an essential defining presupposition, and expanded communicative conceptual parameters that include religion in definitions of diversity and generic principles of excellent practice. An anecdotal review of faith communities in the U.S. reveals that public relations professionals and other communicators model the conceptual framework in interfaith initiatives and that the framework would serve as a helpful foundation for guiding communication professionals toward such behaviour. The study also illustrates that socially-responsible behaviour often has a foundation of faith common across various faith traditions.

  19. Public participation processes related to nuclear research installations: what are the driving factors behind participation intention?

    Science.gov (United States)

    Turcanu, Catrinel; Perko, Tanja; Laes, Erik

    2014-04-01

    This article addresses organised public participation processes related to installations for nuclear research. The aim was to determine predictors that could provide an empirical insight into the motivations underlying people's intended level of involvement. The results highlight attitude towards participation and moral norm as the strongest predictors for participation intention. Other significant predictors were time constraints, attitude towards nuclear energy, subjective and descriptive norms, and knowledge. An opposing relationship is noted between participation intention and attitude towards nuclear energy. At the same time, people who are more knowledgeable about the nuclear domain seem more willing to get involved. The analysis also revealed that financial benefits do not influence people's intended involvement in participation processes related to nuclear research installations. The results reported here are based on empirical data from a large-scale public opinion survey (N = 1020) carried out in Belgium during May-June 2011.

  20. Power and trust in organizational relations: an empirical study in Turkish public hospitals.

    Science.gov (United States)

    Bozaykut, Tuba; Gurbuz, F Gulruh

    2015-01-01

    Given the salience of the interplay between trust and power relations in organizational settings, this paper examines the perceptions of social power and its effects on trust in supervisors within the context of public hospitals. Following the theoretical background from which the study model is developed, the recent situation of hospitals within Turkish healthcare system is discussed to further elucidate the working conditions of physicians. Sample data were collected employing a structured questionnaire that was distributed to physicians working at seven different public hospitals. The statistical analyses indicate that perceptions of supervisors' social power affect subordinates' trust in supervisors. Although coercive power is found to have the greatest impact on trust in supervisors, the influence of the power base is weak. In addition, the results show that perceptions of social power differ between genders. However, the results do not support any of the hypotheses regarding the relations between trust in supervisors and the examined demographic variables.

  1. Targeting the Tumor Microenvironment: Focus on Angiogenesis

    Directory of Open Access Journals (Sweden)

    Fengjuan Fan

    2012-01-01

    Full Text Available Tumorigenesis is a complex multistep process involving not only genetic and epigenetic changes in the tumor cell but also selective supportive conditions of the deregulated tumor microenvironment. One key compartment of the microenvironment is the vascular niche. The role of angiogenesis in solid tumors but also in hematologic malignancies is now well established. Research on angiogenesis in general, and vascular endothelial growth factor in particular, is a major focus in biomedicine and has led to the clinical approval of several antiangiogenic agents including thalidomide, bevacizumab, sorafenib, sunitinib, pazopanib, temesirolimus, and everolimus. Indeed, antiangiogenic agents have significantly changed treatment strategies in solid tumors (colorectal cancer, renal cell carcinoma, and breast cancer and multiple myeloma. Here we illustrate important aspects in the interrelationship between tumor cells and the microenvironment leading to tumor progression, with focus on angiogenesis, and summarize derived targeted therapies.

  2. Targeting the tumor microenvironment: focus on angiogenesis.

    Science.gov (United States)

    Fan, Fengjuan; Schimming, Alexander; Jaeger, Dirk; Podar, Klaus

    2012-01-01

    Tumorigenesis is a complex multistep process involving not only genetic and epigenetic changes in the tumor cell but also selective supportive conditions of the deregulated tumor microenvironment. One key compartment of the microenvironment is the vascular niche. The role of angiogenesis in solid tumors but also in hematologic malignancies is now well established. Research on angiogenesis in general, and vascular endothelial growth factor in particular, is a major focus in biomedicine and has led to the clinical approval of several antiangiogenic agents including thalidomide, bevacizumab, sorafenib, sunitinib, pazopanib, temesirolimus, and everolimus. Indeed, antiangiogenic agents have significantly changed treatment strategies in solid tumors (colorectal cancer, renal cell carcinoma, and breast cancer) and multiple myeloma. Here we illustrate important aspects in the interrelationship between tumor cells and the microenvironment leading to tumor progression, with focus on angiogenesis, and summarize derived targeted therapies.

  3. Mesoscopic and continuum modelling of angiogenesis

    KAUST Repository

    Spill, F.

    2014-03-11

    Angiogenesis is the formation of new blood vessels from pre-existing ones in response to chemical signals secreted by, for example, a wound or a tumour. In this paper, we propose a mesoscopic lattice-based model of angiogenesis, in which processes that include proliferation and cell movement are considered as stochastic events. By studying the dependence of the model on the lattice spacing and the number of cells involved, we are able to derive the deterministic continuum limit of our equations and compare it to similar existing models of angiogenesis. We further identify conditions under which the use of continuum models is justified, and others for which stochastic or discrete effects dominate. We also compare different stochastic models for the movement of endothelial tip cells which have the same macroscopic, deterministic behaviour, but lead to markedly different behaviour in terms of production of new vessel cells. © 2014 Springer-Verlag Berlin Heidelberg.

  4. COX-2, VEGF and tumour angiogenesis.

    LENUS (Irish Health Repository)

    Toomey, D P

    2009-06-01

    Epidemiological evidence suggests a protective effective of regular NSAID use against developing cancer. Cyclooxygenase-2, a target of NSAIDs, is upregulated in many cancers and has been associated with increased VEGF production and angiogenesis. Angiogenesis is the formation of new vessels from existing vasculature and as an essential process for tumour development represents an important therapeutic target. Following an extensive review of the literature this article details the current knowledge on the role of COX-2 in tumorigenesis focusing on its relationship to angiogenesis and VEGF production by tumour cells. While COX-2 is clearly detrimental to prognosis and NSAIDs have a beneficial effect, the possibility of COX-2 independent effects being partly or wholly responsible for this benefit cannot be excluded.

  5. The use of technology in relationship management: a public relations perspective.

    OpenAIRE

    2008-01-01

    The statement that the stable and developed world known to us no longer exists seems to be particularly relevant to the way in which organisations conduct their business and reposition themselves in the communication age. Organisations, as the context within which public relations functions, are threatened by increased competition and changes in key elements of market relationships as a result of global information technology developments and the mobility of organisations and people. The emer...

  6. Advancing the country image construct from a public relations perspective: from model to measurement

    OpenAIRE

    Buhmann, Alexander; Ingenhoff, Diana

    2017-01-01

    Purpose – The purpose of this paper is to develop and test a new model for the measurement of the constitution and effects of the country image as a central target construct in international public relations. Design/methodology/approach – The authors combine concepts from reputation management (Eisenegger and Imhof, 2008; Ingenhoff and Sommer, 2007), national identity theory (Smith, 1987), and attitude theory (Ajzen and Fishbein, 1980) to derive a four-dimensional model, conceptualizing count...

  7. Accounts from the field: a public relations perspective on global AIDS/HIV.

    Science.gov (United States)

    Bardhan, Nilanjana R

    2002-01-01

    This study is a theoretical as well as empirical exploration of the power and cultural differentials that mark and construct various intersecting discourses, specifically media discourse, on global AIDS/HIV. It applies the language and concepts of public relations to understand how the press coverage of the pandemic is associated with the variables that impact the newsmaking process as well as the public and policy implications of macro news frames generated over time. Theoretical work in the areas of agenda setting and news framing also instruct the conceptual framework of this analysis. Narrative analysis is used as a methodology to qualitatively analyze three pools of accounts-from people either living with AIDS/HIV, involved in AIDS/HIV work, or discursively engaged in the media construction of the pandemic; from transnational wire service journalists who cover the issue at global and regional levels; and policy shapers and communicators who are active at the global level. These three communities of respondents represent important stakeholders in the AIDS/HIV issue. The findings are analyzed from a public relations standpoint. Perhaps the most important finding of this study is that the public relations approaches used to address AIDS/HIV related issues need to be grounded in context-specific research and communicative practices that bring out the lived realities of AIDS/HIV at grassroots levels. The findings also posit that those situated at critical junctions between various stakeholders need to cultivate a finely balanced understanding of the etic and emic intersections and subjectivities of global/local AIDS/HIV.

  8. On the role of research data centres in the management of publication-related research data

    Directory of Open Access Journals (Sweden)

    Sven Vlaeminck

    2014-04-01

    Full Text Available This paper summarizes the findings of an analysis of scientific infrastructure service providers (mainly from Germany but also from other European countries. These service providers are evaluated with regard to their potential services for the management of publication-related research data in the field of social sciences, especially economics. For this purpose we conducted both desk research and an online survey of 46 research data centres (RDCs, library networks and public archives; almost 48% responded to our survey. We find that almost three-quarters of all respondents generally store externally generated research data – which also applies to publication-related data. Almost 75% of all respondents also store and host the code of computation or the syntax of statistical analyses. If self-compiled software components are used to generate research outputs, only 40% of all respondents accept these software components for storing and hosting. Eight out of ten institutions also take specific action to ensure long-term data preservation. With regard to the documentation of stored and hosted research data, almost 70% of respondents claim to use the metadata schema of the Data Documentation Initiative (DDI; Dublin Core is used by 30 percent (multiple answers were permitted. Almost two-thirds also use persistent identifiers to facilitate citation of these datasets. Three in four also support researchers in creating metadata for their data. Application programming interfaces (APIs for uploading or searching datasets currently are not yet implemented by any of the respondents. Least common is the use of semantic technologies like RDF.Concluding, the paper discusses the outcome of our survey in relation to Research Data Centres (RDCs and the roles and responsibilities of publication-related data archives for journals in the fields of social sciences.

  9. PUBLIC HEALTH IMPORTANCE OF SHATKRIYAKALA IN RELATION TO NATURAL HISTORY OF DISEASE

    OpenAIRE

    Janmejaya Samal

    2013-01-01

    Kriyakala, also known as Shatkriyakala, is predominantly a concept of Ayurveda which describes different phases of disease formation in its own unique way. This concept can be comparable with natural history of disease in modern medicine. Though many authorities compare it simply with pathogenesis but a meticulous look will reveal its relation with natural history of disease. A good understanding of natural history of disease helps to frame public health intervention strategies, more speciall...

  10. Institutional comunication and cultural marketing: Peculiarities in museum communication within the framework of public relations

    OpenAIRE

    Camelia BURGHELE

    2011-01-01

    Cultural management theoreticians believe that the main target of museum communication is gaining knowledge on specific messages by as large a number of people as possible. Museum public relation practice – intensified and upgraded at the same time with the revolution of the new communication technologies – is both science and art which analyse certain tendences (in attitude, taste and informal) of anticipating their consequences for implementing certain museum offer programs to appeal to the...

  11. Public Relations for Physics Departments: Convincing the Community that Quarks are Cool

    Science.gov (United States)

    Levine, Alaina G.

    2002-03-01

    A strong public relations program can be of great importance to a physics department. Not only can effective PR improve the reputation of an individual department, but it can also serve the greater physics community by convincing the public that quarks, quantum dots, and nanostructures are cool. Building a solid reputation with the many constituents that a physics department serves can lead to greater media exposure, improved quality of student applicants, community and industrial partnerships, and even financial support. It isn’t difficult to create a strategic PR program, but it does take planning and commitment of resources. I will discuss the techniques and tactics of effective media, community, alumni, and internal relations, with special emphasis placed on establishing connections with media outlets, creating and publicizing outreach programs for the community, initiating a newsletter, organizing an external board of advisors, and developing an effective alumni relations program. The University of Arizona Physics Department serves as a case study, but other physics departments with similar communications programs will also be incorporated.

  12. [Work regulation in the context of new public versus private relations in health].

    Science.gov (United States)

    Barbosa, Nelson Bezerra

    2010-08-01

    This work discusses the management of the work relations in the context of the new systems of public vs. private relation in health, having as reference the experience of the habilitation of Social Organizations (SO), responsible for the administration of a group of hospitals in the state of São Paulo. The urgency in this kind of management supported on the legal figure of the SO has implications in the management of Human Resources in Health (HRH) through the adoption of flexibilization mechanisms which include ways of selection, hiring and dismissal, payment rules and functional progression similar to the actions adopted by the market. The establishment of this sort of administration refers to the new paradigm proposed by the managerial administrative reform which suggests the exhaustion of the bureaucratic model to promote adjustment of the public administration to the transformations originated in the new stage of internationalization of the economy and its unfolding in the work world, as well as to the new standards of requirements of performance of the public field. Aspects related to the management of HHR are approached in the two ruling modalities in the Secretaria de Estado da Saúde de São Paulo: Direct Administration Hospitals (DAH) and units organized under the SO model (SOH).

  13. Relative vulnerability of public supply wells to VOC contamination in hydrologically distinct regional aquifers

    Science.gov (United States)

    Kauffman, L.J.; Chapelle, F.H.

    2010-01-01

    A process-based methodology was used to compare the vulnerability of public supply wells tapping seven study areas in four hydrologically distinct regional aquifers to volatile organic compound (VOC) contamination. This method considers (1) contributing areas and travel times of groundwater flowpaths converging at individual supply wells, (2) the oxic and/or anoxic conditions encountered along each flowpath, and (3) the combined effects of hydrodynamic dispersion and contaminant- and oxic/anoxic-specific biodegradation. Contributing areas and travel times were assessed using particle tracks generated from calibrated regional groundwater flow models. These results were then used to estimate VOC concentrations relative to an unspecified initial concentration (C/C0) at individual public supply wells. The results show that the vulnerability of public supply wells to VOC contamination varies widely between different regional aquifers. Low-recharge rates, long travel times, and the predominantly oxic conditions characteristic of Basin and Range aquifers in the western United States leads to lower vulnerability to VOCs, particularly to petroleum hydrocarbons such as benzene and toluene. On the other hand, high recharge rates and short residence times characteristic of the glacial aquifers of the eastern United States leads to greater vulnerability to VOCs. These differences lead to distinct patterns of C/C0 values estimated for public supply wells characteristic of each aquifer, information that can be used by resource managers to develop monitoring plans based on relative vulnerability, to locate new public supply wells, or to make land-use management decisions. Journal compilation ?? 2010 National Ground Water Association. No claim to original US government works.

  14. Micro-blogging and Crisis Public Relation of Public Administration%微博与公共管理部门危机公关

    Institute of Scientific and Technical Information of China (English)

    郭慧

    2012-01-01

    在微博时代,提升公共管理部门危机公关能力,首先要充分认识公共管理部门危机传播的特点与规律,其次,要坚持公共管理部门危机公关管理的基本原则。政府公关人员要借助政务微博在危机公关管理中的“微”力。%If we want to improve the crisis public relation ability of the public administrative departments, firstly, we must be fully aware of the regularity and characteristics of crisis spread of the public administrative departments, and secondly we must adhere to the basic principles of the crisis public relation management of the public administrative departments. The governmental public relations staff should learn to use the "micro" force of the crisis public relations management in the administrative miero-blogging.

  15. Monitoring angiogenesis using magnetic resonance methods

    DEFF Research Database (Denmark)

    Holm, David Alberg

    2008-01-01

    and the involved signaling molecules. Subsequently, a short review of contrast agents and perfusion measurements is given. Finally, methods for monitoring angiogenesis using magnetic resonance imaging are reviewed. A method for monitoring early stages of angiogenesis as well as the effect of anti......-angiogenic treatment is presented in the first manuscript. In the second and third manuscript, two separate methods of quantifying perfusion, blood volume and vessel permeability are presented. The methods are used to show that drug delivery to a xenografted tumor is plausible and to show possible vascular maturation...

  16. Study on Angiogenesis Factor of Human Osteosarcoma

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Angiogenesis factor of human osteosarcoma was partially purified and its biological features were studied. The active peptide with 8000 to 10 000 u molecular weight in the conditioned medium obtained from the cultivation of human osteosarcoma cells were partially purified by ultrafiltration, chromatography and dialysis. The angiogenic effects of the fractions were assessed by proliferation assay of human umbilical vein and pig aorta thoracic endothelial cells. The results showed that the chromatography fractions of 4 to 6 could significantly promote the proliferation of the endothelial cells. It was suggested that the human osteosarcoma cells could synthesize and secrete angiogenesis factor with a molecular weight of 8000 to 10 000 u.

  17. Angiogenesis and vascular targeting: Relevance for hyperthermia

    DEFF Research Database (Denmark)

    Horsman, Michael R

    2008-01-01

    The creation of a functional blood supply from the normal tissue vasculature via the process of angiogenesis is critical for the continued growth and development of solid tumours. This importance has led to the concept of targeting the tumour vasculature as a therapeutic strategy, and two major...... types of vascular targeting agents (VTAs) have developed; those that inhibit the angiogenic process-angiogenesis inhibiting agents (AIAs)-and those that specifically damage the already established neovasculature-vascular disrupting agents (VDAs). The tumour vasculature also plays a critical role...

  18. In Vivo Models of Muscle Angiogenesis.

    Science.gov (United States)

    Egginton, Stuart

    2016-01-01

    Angiogenesis is an important determinant of tissue function, from delivery of oxygen and other substrates to removal of waste products, in health and disease (e.g., adaptive or pathological remodelling). The phenotype and functional responses of endothelial cells are conditioned by systemic humoral signals and local environmental factors, including the haemodynamic forces that act upon them. Here we describe some interventions that have been helpful in unraveling the integrative nature of the complex in vivo response, and quantitative assessment of angiogenesis in muscle.

  19. Reaching out for patients: public relations and events with real results.

    Science.gov (United States)

    Kuechel, Marie Czenko

    2010-02-01

    In today's market, the aesthetic physician needs to connect with patients using methods that are personal, educational, and that will glean the interest of prospective patients whose attention and dollars are sought by countless facial plastic surgery competitors near and far. Public relations, or reaching your prospective patient without a direct solicitation (advertising) for services, are traditional means that include media relations and charitable and social events. With the added component of social media, today the opportunities to reach out for new patients and garner real results are more varied and more affordable than ever before.

  20. Peran Public Relations melalui Kegiatan Corporate Social Responsibility (CSR Islami Berbasis Pemberdayaan Masyarakat

    Directory of Open Access Journals (Sweden)

    Prima Ayu Rizqi Mahanani

    2015-12-01

    Full Text Available Image (good image is a valuable asset to a company for participating into the carrying capacity in the face of increasingly fierce competition in this era of globalization. So it becomes a moral obligation and operations to build a good image of the company that is one of the Corporate Social Responsibility (CSR. This requires a strategic role of public relations in order to carry out CSR activities are on target and provide the benefit that aims to empower the community or the community at large. The strategic role of public relations is expected to be a strategic tool for management to achieve its goals. This paper attempts to analyze the descriptive CSR activities that have been carried out by two national companies / multinational in Indonesia and one government-owned enterprises are not just mere charity but aims to empower the people of Indonesia. With the intention of reviewing the CSR program that truly provide benefit to the independence of program beneficiaries, not become dependent, and not merely interpreted deeds alone company. So that later people perceive right to CSR which is a form of actualization of corporate responsibility and communication between the company and the public. Among prorgam CSR conducted by Telkomsel, Sinar Mas, and the Bank by making strategic empowerment activities with a primary focus on education and training, sports, health, agriculture, infrastructure, social, cultural, environmental maintenance, local business development, partnerships and small businesses. All the CSR program aimed at the development of human resources and better adapted to the real needs (real need community. Keywords: Public Relations, CSR, Empowerment

  1. Angiogenesis-associated crosstalk between collagens, CXC chemokines, and thrombospondin domain-containing proteins.

    Science.gov (United States)

    Rivera, Corban G; Bader, Joel S; Popel, Aleksander S

    2011-08-01

    Excessive vascularization is a hallmark of many diseases including cancer, rheumatoid arthritis, diabetic nephropathy, pathologic obesity, age-related macular degeneration, and asthma. Compounds that inhibit angiogenesis represent potential therapeutics for many diseases. Karagiannis and Popel [Proc. Natl. Acad. Sci. USA 105(37):13775-13780, 2008] used a bioinformatics approach to identify more than 100 peptides with sequence homology to known angiogenesis inhibitors. The peptides could be grouped into families by the conserved domain of the proteins they were derived from. The families included type IV collagen fibrils, CXC chemokine ligands, and type I thrombospondin domain-containing proteins. The relationships between these families have received relatively little attention. To investigate these relationships, we approached the problem by placing the families of proteins in the context of the human interactome including >120,000 physical interactions among proteins, genes, and transcripts. We built on a graph theoretic approach to identify proteins that may represent conduits of crosstalk between protein families. We validated these findings by statistical analysis and analysis of a time series gene expression data set taken during angiogenesis. We identified six proteins at the center of the angiogenesis-associated network including three syndecans, MMP9, CD44, and versican. These findings shed light on the complex signaling networks that govern angiogenesis phenomena.

  2. The effects of CD147 on the cell proliferation, apoptosis, invasion, and angiogenesis in glioma.

    Science.gov (United States)

    Yin, Haoyuan; Shao, Ying; Chen, Xuan

    2017-01-01

    To analyze the effects of extracellular matrix metalloproteinase inducer (CD147) on glioma proliferation, apoptosis, invasion, and angiogenesis. Tissue samples were obtained from 101 glioma cases while normal brain tissues were obtained from 30 brain injury cases. Immunohistochemical assay was performed to detect the expressions of CD147, CD34, and VEGF in tissue samples. QRT-PCR was performed to detect the relative expression of CD147 mRNA in human glioma cell lines. CD147 siRNA was transfected into glioma cell line U251. Cell proliferation, apoptosis, invasion, and angiogenesis were tested by MTT, flow cytometry, Transwell assay, and vasculogenic mimicry assay, respectively. Expressions of relative proteins were analyzed with western blot. CD147 was positively expressed with the percentage of 0, 37.5, 44.8, 67.9, and 85.7 % in normal tissues and glioma tissues with WHO grades I-IV, respectively, and the scores of MVDand VEGF were associated with the expression of CD147. CD147 was significantly upregulated in the human glioma cell lines (P CD147 suppressed cell proliferation, blocked cell cycle, induced apoptosis, inhibited cell invasion and angiogenesis in glioma cells in vitro. The expression of CD147 was significantly associated with WHO tumor grade and angiogenesis; silencing of CD147 contributed to inhibition of glioma proliferation, invasion, and angiogenesis. Our study provided firm evidence that CD 147 is a potential glioma target for anti-angiogenic therapies.

  3. HIF-2alpha-dependent PAI-1 induction contributes to angiogenesis in hepatocellular carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Geis, Theresa, E-mail: geis@biochem.uni-frankfurt.de [Institute of Biochemistry I—Pathobiochemistry, Faculty of Medicine, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main (Germany); Döring, Claudia, E-mail: C.Doering@em.uni-frankfurt.de [Dr. Senckenberg Institute of Pathology, Faculty of Medicine, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main (Germany); Popp, Rüdiger, E-mail: popp@vrc.uni-frankfurt.de [Institute for Vascular Signalling, Centre for Molecular Medicine, Faculty of Medicine Medicine, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60596 Frankfurt am Main (Germany); Grossmann, Nina, E-mail: grossmann@biochem.uni-frankfurt.de [Institute of Biochemistry I—Pathobiochemistry, Faculty of Medicine, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main (Germany); Fleming, Ingrid, E-mail: fleming@vrc.uni-frankfurt.de [Institute for Vascular Signalling, Centre for Molecular Medicine, Faculty of Medicine Medicine, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60596 Frankfurt am Main (Germany); Hansmann, Martin-Leo, E-mail: m.l.hansmann@em.uni-frankfurt.de [Dr. Senckenberg Institute of Pathology, Faculty of Medicine, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main (Germany); Dehne, Nathalie, E-mail: dehne@biochem.uni-frankfurt.de [Institute of Biochemistry I—Pathobiochemistry, Faculty of Medicine, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main (Germany); Brüne, Bernhard, E-mail: b.bruene@biochem.uni-frankfurt.de [Institute of Biochemistry I—Pathobiochemistry, Faculty of Medicine, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main (Germany)

    2015-02-01

    Hypoxia promotes progression of hepatocellular carcinoma (HCC), not only affecting tumor cell proliferation and invasion, but also angiogenesis and thus, increasing the risk of metastasis. Hypoxia inducible factors (HIF)-1α and -2α cause adaptation of tumors to hypoxia, still with uncertainties towards the angiogenic switch. We created a stable knockdown of HIF-1α and HIF-2α in HepG2 cells and generated cocultures of HepG2 spheroids with embryonic bodies as an in vitro tumor model mimicking the cancer microenvironment. The naturally occuring oxygen and nutrient gradients within the cocultures allow us to question the role of distinct HIF isoforms in regulating HCC angiogenesis. In cocultures with a HIF-2α knockdown, angiogenesis was attenuated, while the knockdown of HIF-1α was without effect. Microarray analysis identified plasminogen activator inhibitor 1 (PAI-1) as a HIF-2α target gene in HepG2 cells. The knockdown of PAI-1 in HepG2 cells also lowered angiogenesis. Blocking plasmin, the downstream target of PAI-1, with aprotinin in HIF-2α knockdown (k/d) cells proved a cause–effect relation and restored angiogenesis, with no effect on control cocultures. Suggestively, HIF-2α increases PAI-1 to lower concentrations of active plasmin, thereby supporting angiogenesis. We conclude that the HIF-2α target gene PAI-1 favors the angiogenic switch in HCC. - Highlights: • HepG2 were cocultured with stem cells to mimic a cancer microenvironment in vitro. • A knockdown of HIF-2α reduces angiogenesis. • PAI-1 was identified as a HIF-2α target gene in HCC by microarray analysis. • HIF-2α induces the angiogenic switch via inhibition of plasmin.

  4. Hypoxia inducible factor: It’s role in angiogenesis and tumor

    Directory of Open Access Journals (Sweden)

    Mozhgan Jahani

    2016-02-01

    Full Text Available Angiogenesis, as the process of new vessel formation from pre-existing vessels is dependent on a delicate equilibrium between endogenous angiogenic and antiangiogenic factors. However, under pathological conditions, this tight regulation becomes lost which can result in the formation of the different diseases such as cancer. Angiogenesis is a complex process that includes many gene products that are produced by different cells. Each of the processes influenced by specific genes that their expression can be regulated by hypoxi inducible factor-1 (HIF-1. Hypoxia, the imbalance between the oxygen in need and the oxygen available, usually occurs in tumors and ischemic cardiovascular diseases. In order to overcome this challenge, tumors regulate and control the expression of genes related to angiogenesis, cell cycle and metabolism using hypoxia-inducible factor 1 (HIF-1. HIF-1 was first recognized as a transcription factor involved in hypoxia-induced erythropoietin expression. As angiogenesis pathway molecules are being described, this factor has been characterized as a key transcription regulator for these molecules. In this review article, after discussing HIF-1 structure and characterization, the role of this important factor in angiogenesis and cancer as a pathological case and finally, the clinical applications has been evaluated. Articles related to the key words of hypoxia, HIF-1 and angiogenesis were searched from valid databases such as Springer Link, google scholar, Pubmed and Sciencedirect. Then, the articles related to the role of hypoxia and HIF-1 in activation of genes that are involved in angiogenesis and cancer were searched and selected for this study. Studies show that, HIF-1 activation of genes including vascular endothelial growth factor (VEGF, angiopoietin-1 (Ang-1 and angiopoietin-2 (Ang-2, etc., induced angiogenesis in the tumor cells. Furthermore, the activation of genes such as insulin-like growth factor 2 (IGF2

  5. Role of endogenous angiogenesis inhibitors in Down syndrome.

    Science.gov (United States)

    Ryeom, Sandra; Folkman, Judah

    2009-03-01

    New blood vessel growth via angiogenesis is a fundamental process in both physiological and pathological conditions. Physiological angiogenesis is critical during embryogenesis and placental development, whereas pathological angiogenesis plays an important role in the progression of many diseases, most notably tumor growth. Tumor angiogenesis is well accepted to be regulated by a balance of proangiogenic and antiangiogenic factors produced both by tumor cells and surrounding stromal cells. For many years, investigation of antiangiogenic therapies for cancer has focused on the proangiogenic cytokine, vascular endothelial growth factor; its receptors; or downstream signaling pathways. However, more recently with the identification of endogenous angiogenesis inhibitors, studies have turned toward understanding the role of endogenous antiangiogenic proteins in preventing disease progression. Clinical clues have suggested that specific populations may have dysregulated angiogenesis due to differential expression of endogenous angiogenesis regulators. For example, individuals with Down syndrome may possess a systemic antiangiogenic state with a significantly decreased incidence of angiogenesis-dependent diseases. Our work suggests that endogenous angiogenesis inhibitors may be the master regulators controlling progression of angiogenesis-dependent diseases such as vascular anomalies and cancer. The molecular regulation of angiogenesis is not yet fully understood; however, the Down syndrome population may give us insights toward novel therapies for controlling angiogenesis in disease.

  6. A Dialogue with Social Media Experts: Measurement and Challenges of Social Media Use in Chinese Public Relations Practice

    OpenAIRE

    Yi Luo; Hua Jiang

    2012-01-01

    With the advent and increasing popularity of new communication technologies, social media tools have been widely used in corporate organization-public communication. The extant literature on social media use in public relations practice has largely centered on the ways social media tools have transformed the practice of public relations in the United States. Limited studies have examined the role of social media in China. The present study represents one of the first to investigate the measur...

  7. Health-related behaviour among managers of Slovenian hospitals and institutes of public health

    Directory of Open Access Journals (Sweden)

    Jerneja Farkas

    2015-12-01

    Full Text Available Aim: Behavioural risk factors have a significant impact on health. We aimed to assess health-related behaviour, health status, and use of healthcare services among managers of Slovenian hospitals and institutes of public health. Methods: This was a cross-sectional study which included management (directors, scientific directors, directors’ deputies of Slovenian hospitals and institutes of public health (63 respondents; 57% women; overall mean age: 51±7 years; response rate: 74%. Data were obtained using an anonymous self-administered questionnaire. Results: About 35% of respondents were directors. More than half of the respondents were overweight or obese (52%, the majority were not sufficiently physically active (59% and overloaded with stress (87%. Hypercholesterolemia (36%, spinal disease (17%, and arterial hypertension (16% were most common chronic diseases. Whilst only few participants visited their general practitioner due their health complaints, blood pressure (76%, cholesterol (51%, and glucose (54% were measured within last year in most of the respondents. Conclusion: Our findings point to a high prevalence of overweight and obesity as well as workplace-related stress among Slovenian public health managers. Therefore, effective preventive strategies should be focused on stress management along with promotion of healthy behavioural patterns.

  8. Public attitudes towards pricing policies to change health-related behaviours: a UK focus group study

    Science.gov (United States)

    Marteau, Theresa M.; Kinmonth, Ann Louise; Cohn, Simon

    2015-01-01

    Background: Evidence supports the use of pricing interventions in achieving healthier behaviour at population level. The public acceptability of this strategy continues to be debated throughout Europe, Australasia and USA. We examined public attitudes towards, and beliefs about the acceptability of pricing policies to change health-related behaviours in the UK. The study explores what underlies ideas of acceptability, and in particular those values and beliefs that potentially compete with the evidence presented by policy-makers. Methods: Twelve focus group discussions were held in the London area using a common protocol with visual and textual stimuli. Over 300 000 words of verbatim transcript were inductively coded and analyzed, and themes extracted using a constant comparative method. Results: Attitudes towards pricing policies to change three behaviours (smoking, and excessive consumption of alcohol and food) to improve health outcomes, were unfavourable and acceptability was low. Three sets of beliefs appeared to underpin these attitudes: (i) pricing makes no difference to behaviour; (ii) government raises prices to generate income, not to achieve healthier behaviour and (iii) government is not trustworthy. These beliefs were evident in discussions of all types of health-related behaviour. Conclusions: The low acceptability of pricing interventions to achieve healthier behaviours in populations was linked among these responders to a set of beliefs indicating low trust in government. Acceptability might be increased if evidence regarding effectiveness came from trusted sources seen as independent of government and was supported by public involvement and hypothecated taxation. PMID:25983329

  9. Public Health-Related Impacts of Climate Change inCalifornia

    Energy Technology Data Exchange (ETDEWEB)

    Drechsler, D.M.; Motallebi, N.; Kleeman, M.; Cayan, D.; Hayhoe,K.; Kalkstein, L.S.; Miller, N.L.; Jin, J.; VanCuren, R.A.

    2005-12-01

    In June 2005 Governor Arnold Schwarzenegger issued Executive Order S-3-05 that set greenhouse gas emission reduction targets for California, and directed the Secretary of the California Environmental Protection Agency to report to the governor and the State legislature by January 2006 and biannually thereafter on the impacts to California of global warming, including impacts to water supply, public health, agriculture, the coastline, and forestry, and to prepare and report on mitigation and adaptation plans to combat these impacts. This report is a part of the report to the governor and legislature, and focuses on public health impacts that have been associated with climate change. Considerable evidence suggests that average ambient temperature is increasing worldwide, that temperatures will continue to increase into the future, and that global warming will result in changes to many aspects of climate, including temperature, humidity, and precipitation (McMichael and Githeko, 2001). It is expected that California will experience changes in both temperature and precipitation under current trends. Many of the changes in climate projected for California could have ramifications for public health (McMichael and Githeko, 2001), and this document summarizes the impacts judged most likely to occur in California, based on a review of available peer-reviewed scientific literature and new modeling and statistical analyses. The impacts identified as most significant to public health in California include mortality and morbidity related to temperature, air pollution, vector and water-borne diseases, and wildfires. There is considerable complexity underlying the health of a population with many contributing factors including biological, ecological, social, political, and geographical. In addition, the relationship between climate change and changes in public health is difficult to predict for the most part, although more detailed information is available on temperature-related

  10. CANSTATIN, A ENDOGENOUS INHIBITOR OF ANGIOGENESIS AND TUMOR GROWTH

    Institute of Scientific and Technical Information of China (English)

    苏影; 朱建思

    2004-01-01

    Canstatin is a novel inhibitor of angiogenesis and tumor growth, derived from the C-terminal globular non-collageneous (NCl) domain of the (2 chain of type IV collagen. It inhibits endothelial cell proliferation and migration in a dose-dependent manner, and induces endothelial cell apoptosis. In vivo experiments show that canstatin significantly inhibits solid tumor growth. The canstatin mediated inhibition of tumor is related to apoptosis. Canstatin- induced apoptosis is associated with phosphatidylinositol 3-kinase/Akt inhibition and is dependend upon signaling events transduced trough membrane death receptor.

  11. Multicultural, Intercultural Diversity--What Do We Call "It" and How Do These Terms Show Up in Public Relations Efforts?

    Science.gov (United States)

    Neff, Bonita Dostal

    Diversity should be first understood from an individual's own culture. Yet few public relations professionals have had a course in interpersonal communication. If public relations is viewed as a profession where the management of people is important, then knowledge of diversity in the workplace seems imperative. The multicultural, intercultural,…

  12. Organizing an Effective Public Relations Program for the Stroudsberg Area School District. Maxi I and Maxi II, Final Report.

    Science.gov (United States)

    Santoro, Thomas J.

    The purpose of this project was to organize an effective, comprehensive, public relations program in a medium size school district and, hopefully, increase the image of the district. The data contained in this report will demonstrate a clear need for the organization of a public relations program, the extent to which an effective, comprehensive…

  13. 38 CFR 1.486 - Disclosure of information related to infection with the human immunodeficiency virus to public...

    Science.gov (United States)

    2010-07-01

    ... related to infection with the human immunodeficiency virus to public health authorities. 1.486 Section 1... Disclosures Without Patient Consent § 1.486 Disclosure of information related to infection with the human immunodeficiency virus to public health authorities. (a) In the case of any record which is maintained...

  14. Applying Ajzen's Theory of Planned Behavior to a Study of Online Course Adoption in Public Relations Education

    Science.gov (United States)

    Knabe, Ann Peru

    2012-01-01

    This study used Icek Ajzen's Theory of Planned Behavior to research public relations faculty intentions of teaching online. All of the main predictor variables (Subjective Norms, Attitude toward the Act and Perceived Behavioral Control) were statistically significant at varying degrees in predicting intent to teach public relations online. Of the…

  15. Dressing for Battle in the New Global Economy: Putting Power, Identity, and Discourse Into Public Relations Theory.

    Science.gov (United States)

    Weaver, C. Kay

    2001-01-01

    Argues that public relations theorists need to acknowledge their generally unspoken support for corporate capitalist power and to reconsider that support in the context of the new economy. Suggests such a move would encourage consideration of whether public relations scholarship should be contributing uncritically to the development of a…

  16. [Urgent action needed to raise public awareness of age-related macular degeneration in China].

    Science.gov (United States)

    Chen, You-xin

    2009-05-01

    Age-related macular degeneration (AMD) is the leading cause of blindness in developed countries. The impact of AMD to the economics, society and the patients are huge. However, the awareness of AMD is alarmingly low. Even in developed countries, the awareness of AMD is below 30%. In terms of the risk factors of AMD, the awareness is also quite low, e.g., only 32% were aware of the causal link between smoking and AMD. Although cataract is the leading cause of the blindness in China, as the economic and social progress, as the coming of the aging society, as people pursuing higher quality of life, AMD will become a unignoring public health problem. Thus, it is urgent to take action now to increase the public awareness of AMD.

  17. Liberalization of energy markets: local policies of public-private contractual relations; Liberalisation des marches energetiques: les politiques locales de relations contractuelles public-prive

    Energy Technology Data Exchange (ETDEWEB)

    Cahn, M.; Schilken, P.

    2001-07-01

    This state-of-the-art focusses on the contractual relations between the local authorities and the private sector in the domain of energy. In the past, specialized services were supplied and internally managed by utilities and monopolies, while today the same services are ensured by private companies selected according to their efficiency and competitiveness. In France, country of centralized tradition, such practices are not really developed while they are already in UK and Germany. This study gives an overview of the advantages of these practices using some examples taken in four domains: the helps to the choice of an electricity supplier and of the quality of power, the contracts of concessions of power distribution, the supply of energy advice services by external experts, and the helps for the investment in the domain of mastery of energy demand. Nine case-forms illustrate the experience of nine European countries in these public-private energy partnerships: Basel (CH), Berlin, Hagen and Heidelberg (DE), Brent, Leicester and Waltham Forest (GB), Graz (AT) and Jablonec (CZ). (J.S.)

  18. Historia y trayectoria de las Relaciones Públicas en Brasil/ History of Public Relations in Brazil

    Directory of Open Access Journals (Sweden)

    Maria Aparecida Ferrari

    2011-05-01

    Full Text Available Durante muchas décadas la enseñanza y la práctica de las Relaciones Públicas en Brasil y demás países de América Latina utilizaron como referencia central un abordaje norteamericano y, en menor escala europea. Tal comportamiento llevó los profesionales a adoptar valores y modelos importados como referencia para nuestro comportamiento organizacional. Desde la década de 1990, con el fenómeno de la globalización y el avance de la tecnología, las Relaciones Públicas pasaron a ejercer un papel más estratégico y menos táctico. Hoy, las Relaciones Públicas son una profesión necesaria para el posicionamiento de las organizaciones en el mercado y también como responsable por las relaciones ente las organizaciones y sus stakeholders. / For many decades the teaching and practice of Public Relations in Brazil and in neighboring Latin American nations have largely relied on a North American and - to a lesser degree - a European perspective. This led our professionals to adopt values and imported models as the main reference for our organizational behavior. Beginning during the 1990’s and a result of globalization and technological development, Public Relations began to behave in a more strategic and less tactical manner. Today, Public Relations is a profession that is required for the positioning of organizations in the marketplace, which is also responsible for the relations between organizations and their stakeholders.

  19. Texas-style Fundraising and Public Relations for the International Year of Astronomy

    Science.gov (United States)

    Preston, Sandra; Barna, J. W.; Geiger, S.; Johnson, R.; Rimm, N.; Griffin, J.; Watson, K.

    2008-05-01

    McDonald Observatory can be a leader in Texas for the International Year of Astronomy (IYA09) celebration. Our strategy builds on the IYA09 program, tailoring it for the Texas audience, while also nationally promoting McDonald Observatory, UT Astronomy, the Hobby-Eberly Telescope Dark Energy Experiment (HETDEX) and our partnership in the Giant Magellan Telescope (GMT). We will also use this opportunity to make a concentrated outreach effort toward the Hispanic and Spanish-speaking communities in Texas and the nation, aligning with the IYA09 objective for improving relations with underrepresented and minority populations. Fundraising is a key ingredient to our success in 2009 and the future. With NASA Office of Space Science funding for education and public outreach being rethought, we will be focusing on new sources for fundraising, including private donations and corporate sponsorship, augmented by planned giving. We will take advantage of the timing to raise funds for special IYA09 programs, as well as for our large telescope projects HETDEX and GMT, along with our endowment and planned giving programs for education, outreach, and research. We will work with the UT McCombs School of Business on corporate sponsorship. During this time we will also go through a branding experience that will visually unify McDonald Observatory, UT Astronomy, and the education and public outreach programs. A consistent brand that can be used on the website and other media is our goal to build a stronger public presence that will aid us in our fundraising efforts. A Public Relations Internship Project produced a report to help launch this process. We are working with the UT College of Communications Advertising Department and with Hill Strategic Brand Solutions in Houston, Texas. We hope that our efforts will produce Texas-sized results!

  20. NATURE OF INTELLECTUAL PROPERTY RELATIONS AND ITS ROLE IN A PUBLIC REPRODUCTION

    Directory of Open Access Journals (Sweden)

    V. Virchenko

    2013-08-01

    Full Text Available Article is devoted to theoretical analysis of nature and structure of intellectual property relations. Types of intellectual property relations and its role in public reproduction are investigated. Peculiarities of intellectual property relations are considered. Two groups of approaches to classification of intellectual property objects are analysed: classification of objects depending on its characteristics which is based on the analysis of their most essential features, specificity of their protection, features of realisation of the property and non-property rights; classification on the basis of various minor criterions which do not reveal nature and character of objects but at the same time allow to divide them into groups according to concrete tasks of research. Necessity of defining of incorporeal objects of intellectual property which cannot be labelled as objects of copyright, industrial property or branding tools is proved. Criteria of classification of party’s to intellectual property relations are investigated. The subject structure of intellectual property relations according to the legislation of Ukraine is defined. New approaches to classification of party’s to intellectual property relations depending on their role in relations of intellectual property and their economic functions are offered, which allow to embrace as much as possible all participants of intellectual property relations, consider their role in the process of commercialisation, and draw attention to subjects which carry out regulating and mediatorial functions on the intellectual property market.

  1. Adaptive angiogenesis in placentas of heavy smokers.

    Science.gov (United States)

    Pfarrer, C; Macara, L; Leiser, R; Kingdom, J

    1999-07-24

    Smoking in pregnancy increases perinatal morbidity and mortality, suggesting impaired placental function, though placental weight is increased. We used scanning electron microscopy to show adaptive angiogenesis in term placental villi from smokers (n=4) and non-smokers (n=4). These images may aid communication of the dangers of smoking in pregnancy.

  2. Fibromodulin Enhances Angiogenesis during Cutaneous Wound Healing

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    Zhong Zheng, PhD

    2014-12-01

    Conclusions: Altogether, we demonstrated that in addition to reducing scar formation, FMOD also promotes angiogenesis. As blood vessels organize and regulate wound healing, its potent angiogenic properties will further expand the clinical application of FMOD for cutaneous healing of poorly vascularized wounds.

  3. Orchestration of angiogenesis by immune cells

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    Antonino eBruno

    2014-07-01

    Full Text Available It is widely accepted that the tumor microenvironment plays a major role in cancer and is indispensable for tumor progression. The tumor microenvironment involves many players going well beyond the malignant-transformed cells, including stromal, immune and endothelial cells. The non-malignant cells can acquire tumor-promoting functions during carcinogenesis. In particular, these cells can orchestrate the symphony of the angiogenic switch, permitting the creation of new blood vessels that allows rapid expansion and progression toward malignancy.Considerable attention within the context of tumor angiogenesis should focus not only on the endothelial cells, representing a fundamental unit, but also on immune cells and on the inflammatory tumor infiltrate. Immune cells infiltrating tumors typically show a tumor-induced polarization associated with attenuation of anti-tumor functions and generation of pro-tumor activities, among these angiogenesis. Here we propose a scenario suggesting that the angiogenic switch is an immune switch arising from the pro-angiogenic polarization of immune cells. This view links immunity, inflammation and angiogenesis to tumor progression. Here we review the data in the literature and seek to identify the conductors of this orchestra. We also suggest that interrupting the immune -> inflammation -> angiogenesis -> tumor progression process can delay or prevent tumor insurgence and malignant disease.

  4. From Aardvark to Zebra: A New Millennium Analysis of Theory Development in Public Relations Academic Journals. A Top Faculty/Student Research Paper.

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    Sallot, Lynne M.; Lyon, Lisa J.; Acosta-Alzuru, Carolina; Jones, Karyn Ogata

    In a replication and extension of a 1984 study by M. A. Ferguson to investigate the status of theory building by public relations scholars, 748 abstracts and/or articles published in "Public Relations Review,""Journal of Public Relations Research," and its predecessor "Public Relations Research Annual," since their inceptions through the year…

  5. Uncovering a new role for peroxidase enzymes as drivers of angiogenesis.

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    Panagopoulos, Vasilios; Zinonos, Irene; Leach, Damien A; Hay, Shelley J; Liapis, Vasilios; Zysk, Aneta; Ingman, Wendy V; DeNichilo, Mark O; Evdokiou, Andreas

    2015-11-01

    Peroxidases are heme-containing enzymes released by activated immune cells at sites of inflammation. To-date their functional role in human health has mainly been limited to providing a mechanism for oxidative defence against invading bacteria and other pathogenic microorganisms. Our laboratory has recently identified a new functional role for peroxidase enzymes in stimulating fibroblast migration and collagen biosynthesis, offering a new insight into the causative association between inflammation and the pro-fibrogenic events that mediate tissue repair and regeneration. Peroxidases are found at elevated levels within and near blood vessels however, their direct involvement in angiogenesis has never been reported. Here we report for the first time that myeloperoxidase (MPO) and eosinophil peroxidase (EPO) are readily internalised by human umbilical vein endothelial cells (HUVEC) where they promote cellular proliferation, migration, invasion, and stimulate angiogenesis both in vitro and in vivo. These pro-angiogenic effects were attenuated using the specific peroxidase inhibitor 4-ABAH, indicating the enzyme's catalytic activity is essential in mediating this response. Mechanistically, we provide evidence that MPO and EPO regulate endothelial FAK, Akt, p38 MAPK, ERK1/2 phosphorylation and stabilisation of HIF-2α, culminating in transcriptional regulation of key angiogenesis pathways. These findings uncover for the first time an important and previously unsuspected role for peroxidases as drivers of angiogenesis, and suggest that peroxidase inhibitors may have therapeutic potential for the treatment of angiogenesis related diseases driven by inflammation.

  6. High-grade ovarian cancer secreting effective exosomes in tumor angiogenesis.

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    Yi, Huan; Ye, Jun; Yang, Xiao-Mei; Zhang, Li-Wen; Zhang, Zhi-Gang; Chen, Ya-Ping

    2015-01-01

    Ovarian cancer, the most lethal gynecological cancer, related closely to tumor stage. High-grade ovarian cancer always results in a late diagnose and high recurrence, which reduce survival within five years. Until recently, curable therapy is still under research and anti-angiogenesis proves a promising way. Tumor-derived exosomes are essential in tumor migration and metastases such as angiogenesis is enhanced by exosomes. In our study, we have made comparison between high-grade and unlikely high-grade serous ovarian cancer cells on exosomal function of endothelial cells proliferation, migration and tube formation. Exosomes derived from high-grade ovarian cancer have a profound impact on angiogenesis with comparison to unlikely high-grade ovarian cancer. Proteomic profiles revealed some potential proteins involved in exosomal function of angiogenesis such as ATF2, MTA1, ROCK1/2 and so on. Therefore, exosomes plays an influential role in angiogenesis in ovarian serous cancer and also function more effectively in high-grade ovarian cancer cells.

  7. The tetrapeptide Arg-Leu-Tyr-Glu inhibits VEGF-induced angiogenesis

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    Baek, Yi-Yong; Lee, Dong-Keon [Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, 200-702 (Korea, Republic of); So, Ju-Hoon; Kim, Cheol-Hee [Department of Biology, Chungnam National University, Daejeon, 305-764 (Korea, Republic of); Jeoung, Dooil [Department of Biochemistry, College of Natural Sciences, Kangwon National University, Chuncheon, Gangwon-do, 200-702 (Korea, Republic of); Lee, Hansoo [Department of Life Sciences, College of Natural Sciences, Kangwon National University, Chuncheon, Gangwon-do, 200-702 (Korea, Republic of); Choe, Jongseon [Department of Immunology, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, 200-702 (Korea, Republic of); Won, Moo-Ho [Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, 200-702 (Korea, Republic of); Ha, Kwon-Soo [Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, 200-702 (Korea, Republic of); Kwon, Young-Guen [Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, 120-752 (Korea, Republic of); Kim, Young-Myeong, E-mail: ymkim@kangwon.ac.kr [Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, 200-702 (Korea, Republic of)

    2015-08-07

    Kringle 5, derived from plasminogen, is highly capable of inhibiting angiogenesis. Here, we have designed and synthesized 10 tetrapeptides, based on the amino acid properties of the core tetrapeptide Lys-Leu-Tyr-Asp (KLYD) originating from anti-angiogenic kringle 5 of human plasminogen. Of these, Arg-Leu-Tyr-Glu (RLYE) effectively inhibited vascular endothelial growth factor (VEGF)-induced endothelial cell proliferation, migration and tube formation, with an IC{sub 50} of 0.06–0.08 nM, which was about ten-fold lower than that of the control peptide KLYD (0.79 nM), as well as suppressed developmental angiogenesis in a zebrafish model. Furthermore, this peptide effectively inhibited the cellular events that precede angiogenesis, such as ERK and eNOS phosphorylation and nitric oxide production, in endothelial cells stimulated with VEGF. Collectively, these data demonstrate that RLYE is a potent anti-angiogenic peptide that targets the VEGF signaling pathway. - Highlights: • The tetrapeptide RLYE inhibited VEGF-induced angiogenesis in vitro. • RLYE also suppressed neovascularization in a zebrafish model. • Its effect was correlated with inhibition of VEGF-induced ERK and eNOS activation. • RLYE may be used as a therapeutic drug for angiogenesis-related diseases.

  8. Public opinion on nutrition-related policies to combat child obesity, Los Angeles County, 2011.

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    Simon, Paul A; Chiang, Choiyuk; Lightstone, Amy S; Shih, Margaret

    2014-06-05

    We assessed public opinion on nutrition-related policies to address child obesity: a soda tax, restrictions on advertising unhealthy foods and beverages to children, and restrictions on siting fast food restaurants and convenience stores near schools. We analyzed data from 998 adults (aged ≥18 years) in the 2011 Los Angeles County Health Survey. Support was highest for advertising restrictions (74%), intermediate for a soda tax (60%), and lowest for siting restrictions on fast food restaurants and convenience stores (44% and 37%, respectively). Support for food and beverage advertising restrictions and soda taxation is promising for future policy efforts to address child obesity.

  9. The Public Stigma of Problem Gambling: Its Nature and Relative Intensity Compared to Other Health Conditions.

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    Hing, Nerilee; Russell, Alex M T; Gainsbury, Sally M; Nuske, Elaine

    2016-09-01

    Problem gambling attracts considerable public stigma, with deleterious effects on mental health and use of healthcare services amongst those affected. However, no research has examined the extent of stigma towards problem gambling within the general population. This study aimed to examine the stigma-related dimensions of problem gambling as perceived by the general public compared to other health conditions, and determine whether the publicly perceived dimensions of problem gambling predict its stigmatisation. A sample of 2000 Australian adults was surveyed, weighted to be representative of the state population by gender, age and location. Based on vignettes, the online survey measured perceived origin, peril, concealability, course and disruptiveness of problem gambling and four other health conditions, and desired social distance from each. Problem gambling was perceived as caused mainly by stressful life circumstances, and highly disruptive, recoverable and noticeable, but not particularly perilous. Respondents stigmatised problem gambling more than sub-clinical distress and recreational gambling, but less than alcohol use disorder and schizophrenia. Predictors of stronger stigma towards problem gambling were perceptions it is caused by bad character, is perilous, non-recoverable, disruptive and noticeable, but not due to stressful life circumstances, genetic/inherited problem, or chemical imbalance in the brain. This new foundational knowledge can advance understanding and reduction of problem gambling stigma through countering inaccurate perceptions that problem gambling is caused by bad character, that people with gambling problems are likely to be violent to other people, and that people cannot recover from problem gambling.

  10. Fiscal education and public efficiency: a study of its relations based on municipal resource management

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    Erivan Ferreira Borges

    2014-12-01

    Full Text Available In this study, the theme fiscal accounting is addressed as a variable that influences the municipal public efficiency, measured through the relation between expenses on governmental functions and own tax revenues. The foundations of fiscal education are presented, based on the premises indicated by the School of Fiscal Management and the Theory of Tax Education (Sainz de Bujanda, 1967, associated with the pedagogical foundations recommended by Saviani (1980; 2008 and Chaves (2007. In methodological terms, in this study, the measuring of the citizens’ level of fiscal education was proposed by means of an electronic questionnaire, applied to a sample of 1,804 respondents. The municipal data were obtained from the database Finanças Brasil – Finbra, directly collected from the website of the Brazilian Secretary of the Treasury, and comprise information on the years 2004 till 2010. The final sample was defined for the efficiency analysis of 689 cities. Initially, the data were treated using Data Envelopment Analysis (DEA and factorial analysis with a view to defining the variables that permitted the application of the multiple regression analysis. Based on the results, the main research hypothesis that the citizens’ fiscal education level serves as an instrument of social control that influences the efficiency of public resource management and enhances the levels of transparency and accountability in the municipal public administration. Studies are recommended to confirm the findings, involving other variables not addressed in the study, such as social indicators, and using other groups the research did not reach.

  11. Institutional comunication and cultural marketing: Peculiarities in museum communication within the framework of public relations

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    Camelia BURGHELE

    2011-01-01

    Full Text Available Cultural management theoreticians believe that the main target of museum communication is gaining knowledge on specific messages by as large a number of people as possible. Museum public relation practice – intensified and upgraded at the same time with the revolution of the new communication technologies – is both science and art which analyse certain tendences (in attitude, taste and informal of anticipating their consequences for implementing certain museum offer programs to appeal to the public.As an institution with a decisive role in guarding cultural heritage and in outlining cultural identity – as it keeps the necessary instruments for this, the specialists and also the motivation through its own purposes – the museum in its dynamic, modern, enhanced shape must provide an attractive cultural product to the public, based on a anthropological approach to cultural fact.Modern museum-ology is built upon the concept that museum is a story and modern museums stimulate to a high degree participative learning, generated by a productive dialogue.

  12. Persisting problems related to race and ethnicity in public health and epidemiology research

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    Jean-Claude Moubarac

    2013-02-01

    Full Text Available A recent and comprehensive review of the use of race and ethnicity in research that address health disparities in epidemiology and public health is provided. First it is described the theoretical basis upon which race and ethnicity differ drawing from previous work in anthropology, social science and public health. Second, it is presented a review of 280 articles published in high impacts factor journals in regards to public health and epidemiology from 2009-2011. An analytical grid enabled the examination of conceptual, theoretical and methodological questions related to the use of both concepts. The majority of articles reviewed were grounded in a theoretical framework and provided interpretations from various models. However, key problems identified include a a failure from researchers to differentiate between the concepts of race and ethnicity; b an inappropriate use of racial categories to ascribe ethnicity; c a lack of transparency in the methods used to assess both concepts; and d failure to address limits associated with the construction of racial or ethnic taxonomies and their use. In conclusion, future studies examining health disparities should clearly establish the distinction between race and ethnicity, develop theoretically driven research and address specific questions about the relationships between race, ethnicity and health. One argue that one way to think about ethnicity, race and health is to dichotomize research into two sets of questions about the relationship between human diversity and health.

  13. Public Understanding and Attitudes towards Meat Chicken Production and Relations to Consumption.

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    Erian, Ihab; Phillips, Clive J C

    2017-03-09

    Little is known about public knowledge of meat chicken production and how it influences attitudes to birds' welfare and consumer behaviour. We interviewed 506 members of the public in SE Queensland; Australia; to determine how knowledge of meat chicken production and slaughter links to attitudes and consumption. Knowledge was assessed from 15 questions and low scores were supported by respondents' self-assessed report of low knowledge levels and agreement that their knowledge was insufficient to form an opinion about which chicken products to purchase. Older respondents and single people without children were most knowledgeable. There was uncertainty about whether chicken welfare was adequate, particularly in those with little knowledge. There was also evidence that a lack of empathy towards chickens related to lack of knowledge, since those that thought it acceptable that some birds are inadequately stunned at slaughter had low knowledge scores. More knowledgeable respondents ate chicken more frequently and were less likely to buy products with accredited labelling. Approximately half of the respondents thought the welfare of the chicken was more important than the cost. It is concluded that the public's knowledge has an important connection to their attitudes and consumption of chicken.

  14. Awakening the Sufferers: Reflections on Public Relations, Activism, and Subalternity in Postcolonial Controversies between Taiwan and Japan

    DEFF Research Database (Denmark)

    Sejrup, Jens

    2014-01-01

    This article is a qualitative analysis of mass-mediated projections of relationships between public relations practitioners in the shape of activist groups and organizations, and subaltern stakeholders for whom they act as public representatives. Drawing my empirical examples from Japan and Taiwan...... and analysing the public relations implications of two politically sensitive and controversial cases, I question the nature of representative relations as reflected in mainstream mass media coverage in these two societies. Doing so, I raise concerns about the critical scope of scholarly interest in activism...... and the representation of other voices in public relations studies and draw on theoretical insights from Spivak, Guha, and others in order to untangle some of the complexities inherent in the mobilization of subaltern groups, here victims of historical abuse and maltreatment. The existence of such complexities in public...

  15. Approach to the research and the situation of Public Relations in Europe. Comparative study between German and Spanish cases

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    Dra. María Isabel Míguez González

    2007-01-01

    Full Text Available With the aim of bring near to the spanish academic field the european approaches of Public Relations, this article makes a compared revision of the situation of this subject and profession in Germany and Spain. This revision shows important resemblances on the use of the term “public relations”, the confusion of this subject with other communicative activities, the professional development and the problems of the field in both countries. However, it also shows that Germany has more tradition on public relations research than Spain and, therefore, it has a more extensive corpus of theories about this subject. For this reason, since important resemblances exist in other aspects, german research on public relations could be interesting for the spanish academic field both to explain the situation of public relations in Spain and to motivate theoretical development in our country.

  16. Evaluating public relations effectiveness in a health care setting. The identification of communication assets and liabilities via a communication audit.

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    Henderson, Julie K

    2005-01-01

    The practice of public relations has experienced tremendous growth and evolution over the past 25 years, especially in the area of medical public relations. The constant changes in health care delivery have often led to increased need for communication with important publics. At the same time, practitioners in all fields of public relations have explored methods of accurately measuring the effectiveness of public relations programs. One such method of evaluation is the communication audit. This paper includes a brief overview of the communication audit concept followed by a case study based on an audit conducted for a small, multicultural non-profit health-care agency. Steps taken to conduct the audit and the methodology used are discussed. An analysis of the data is used to address two research questions regarding the efficacy of the Center's mission and vision. Suggestions for future audits are provided.

  17. Cleavage of galectin-3 by matrix metalloproteases induces angiogenesis in breast cancer

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    Nangia-Makker, Pratima; Wang, Yi; Raz, Tirza; Tait, Larry; Balan, Vitaly; Hogan, Victor; Raz, Avraham

    2012-01-01

    Galectin-3 cleavage is related to progression of human breast and prostate cancer and is partly responsible for tumor growth, angiogenesis and apoptosis resistance in mouse models. A functional polymorphism in galectin-3 gene, determining its susceptibility to cleavage by matrix metalloproteinases (MMPs)-2/-9 is related to racial disparity in breast cancer incidence in Asian and Caucasian women. The purpose of our study is to evaluate (i) if cleavage of galectin-3 could be related to angiogenesis during the progression of human breast cancer, (ii) the role of cleaved galectin-3 in induction of angiogenesis and (iii) determination of the galectin-3 domain responsible for induction of angiogenic response. Galectin-3 null breast cancer cells BT-459 were transfected with either cleavable full-length galectin-3 or its fragmented peptides. Chemotaxis, chemoinvasion, heterotypic aggregation, epithelial-endothelial cell interactions and angiogenesis were compared to noncleavable galectin-3. BT-549-H64 cells harboring cleavable galectin-3 exhibited increased chemotaxis, invasion and interactions with endothelial cells resulting in angiogenesis and 3D morphogenesis compared to BT-549-P64 cells harboring noncleavable galectin-3. BT-549-H64 cells induced increased migration and phosphorylation of focal adhesion kinase in migrating endothelial cells. Endothelial cells cocultured with BT-549 cells transfected with galectin-3 peptides indicate that amino acids 1–62 and 33–250 stimulate migration and morphogenesis of endothelial cells. Immunohistochemical analysis of blood vessel density and galectin-3 cleavage in a breast cancer progression tissue array support the in vitro findings. We conclude that the cleavage of the N terminus of galectin-3 followed by its release in the tumor microenvironment in part leads to breast cancer angiogenesis and progression. PMID:20162566

  18. Public awareness of income-related health inequalities in Ontario, Canada

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    Shankardass Ketan

    2012-05-01

    Full Text Available Abstract Introduction Continued action is needed to tackle health inequalities in Canada, as those of lower income continue to be at higher risk for a range of negative health outcomes. There is arguably a lack of political will to implement policy change in this respect. As a result, we investigated public awareness of income-related health inequalities in a generally representative sample of Ontarians in late 2010. Methods Data were collected from 2,006 Ontario adults using a telephone survey. The survey asked participants to agree or disagree with various statements asserting that there are or are not health inequalities in general and by income in Ontario, including questions pertaining to nine specific conditions for which inequalities have been described in Ontario. A multi-stage process using binary logistic regression determined whether awareness of health inequalities differed between participant subgroups. Results Almost 73% of this sample of Ontarians agreed with the general premise that not all people are equally healthy in Ontario, but fewer participants were aware of health inequalities between the rich and the poor (53%–64%, depending on the framing of the question. Awareness of income-related inequalities in specific outcomes was considerably lower, ranging from 18% for accidents to 35% for obesity. Conclusions This is the first province-wide study in Canada, and the first in Ontario, to explore public awareness on health inequalities. Given that political will is shaped by public awareness and opinion, these results suggest that greater awareness may be required to move the health equity agenda forward in Ontario. There is a need for health equity advocates, physicians and researchers to increase the effectiveness of knowledge translation activities for studies that identify and explore health inequalities.

  19. Halting angiogenesis by non-viral somatic gene therapy alleviates psoriasis and murine psoriasiform skin lesions

    DEFF Research Database (Denmark)

    Zibert, John Robert; Wallbrecht, Katrin; Schön, Margarete

    2011-01-01

    with epidermal expression of human TGF-ß1, we have demonstrated that antiangiogenic non-viral somatic gene therapy reduces the cutaneous microvasculature and alleviates chronic inflammatory skin disorders. Transient muscular expression of the recombinant disintegrin domain (RDD) of metargidin (also known as ADAM...... in all models. Thus, non-viral antiangiogenic gene therapy can alleviate psoriasis and may do so in other angiogenesis-related inflammatory skin disorders.......-15) by in vivo electroporation reduced cutaneous angiogenesis and vascularization in all 3 models. As demonstrated using red fluorescent protein-coupled RDD, the treatment resulted in muscular expression of the gene product and its deposition within the cutaneous hyperangiogenic connective tissue...

  20. Exploratory study of a crisis commander’s perspectives on the role and value of public relations in crisis management

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    Mat Tazin Saidathul Nizah

    2017-01-01

    Full Text Available This is an exploratory study into understanding the dominant coalition perspectives on role and values of public relations in crisis management in an energy company in Malaysia. In this study, the senior public relations of the energy company reports directly to the crisis commander (CC in times of crisis thus, the CC was chosen as a sample where an in-depth interview was conducted. Notably, the CC perceptions represents the dominant coalition with the power to shape organisation policies and provide directions to public relations practice in managing media and communication in crisis management. Theory of excellence within the outlook of public relations empowerment was examined. The findings of this study have significantly confirmed that the patterns of the CC perceptions on role and values of public relations in crisis management are similar to other dominant coalition literature across the globe. This phenomenon needs changes to drive public relations to strive harder to be a problem solver and a strategic thinker in crisis management. This study is a significant attempt to understand the perception of the dominant coalition on public relations in crisis management and can be replicated in other sectors in Malaysia.