WorldWideScience

Sample records for angiocardiography

  1. Iopamidol in pediatric angiocardiography

    International Nuclear Information System (INIS)

    Iopamidol (ISOVUE-370) has been used extensively in adult angiocardiography, but clinical trials in pediatric patients with congenital heart disease are limited. The authors study group comprised 25 children referred for elective cardiac catheterization and cineangiocardiography. Patients were aged 3 months to 15 years (mean, 2 years) and weighted 14-62 kg (mean, 17 kg). Depending on the congenital heart lesion, the total amount of contrast agent injected ranged from 1 to 5 ml/kg. The potential benefits of iopamidol include fewer minor side effects, decreased movement or reaction of the child, and fewer direct effects of contrast agent on biochemical changes, compared with published results of using ionic contrast media. In addition, there were fewer electrocardiographic changes during iopamidol injection, and less change in the end-diastolic pressures after injection compared to results obtained with ionic contrast media. Visual rating of the cineangiograms revealed that all were of diagnostic quality, and 75% were rated as showing ''superior opacification.''

  2. Cardiovascular: radioisotopic angiocardiography

    International Nuclear Information System (INIS)

    Radioisotopic angiocardiography, performed after the intravenous injection of 99/sup m/Tc-labeled pertechnetate or albumin, is a simple, rapid, and safe procedure which permits identification and physiologic assessment of a wide variety of congenital and acquired cardiovascular lesions in infants and children. These include atrial and ventricular septal defect, tetralogy of Fallot, pulmonic stenosis, aortopulmonary window, transposition of the great vessels, valvular stenosis and/or insufficiency, myocardial lesions, and lesions of the great vessels. The simplicity of the procedure lends itself to repeated measurements to assess the effects of therapy or to follow the course of the disease. A wide spectrum of congenital and acquired cardiovascular diseases have been studied which have particular application to the pediatric age group. (auth)

  3. Radionuclide angiocardiography in cogential heart disease

    International Nuclear Information System (INIS)

    In detecting, localizing and quantitating cardiac shunts, radionuclide angiocardiography has been known to be a simple and safe method compared with oxymetry method. To ascertain the availability of the results obtained by radionuclide angiocardiography for the evaluation of patients with cardiac shunt, author compared the Qp/Qs ratios(pulmonary to systemic flow ratios) obtained by radionuclide angiocardiography with the results of oximetry method in 40 patients with left to right shunt, and also compared the results of radionuclide angiocardiography examined before and after shunt operation in 8 patients. The results were as follows: 1) Of the 161 patients examined radionuclide angiocardiography, 98 were thought to have cardiac shunts: right to left shunt in 27, left to right shunt in 71. Of the 71 patients who had left to right shunt, 40 who were examined with both radionuclide angiocardiography and oxymetry has following congenital heart disease: VSD in 21, ASD in 9 and PDA in 10. 2) Comparison of Qp/Qs ratios obtained during radionuclide angiocardiography and oxymetry revealed good correlation(linear regression analysis yielded correlation coefficient of 0.80) in 32 patients whose Qp/Qs ratio obtained during oxymetry were below 3.0, but very poor correlation in 8 patients whose Qp/Qs ratios were above 3.0 3) Radionuclide angiocardiography is a relatively safe and simple method in postoperative evaluation of patients with cardiac shunt. (Author)

  4. Radionuclide Angiocardiography in Cogenital Heart Disease

    International Nuclear Information System (INIS)

    In detecting, localizing and quantitating cardiac shunts, radionuclide angiocardiography has been known to be a simple and safe method compared with oxymetry method. To ascertain the availability of the results obtained by radionuclide angiocardiography for the evaluation of patients with cardiac shunt, author compared the Qp/Qs ratios (pulmonary to systemic flow ratios) obtained by radionuclide angiocardiography with the results of oxymetry method in 40 patients with left to right shunt, and also compared the results of radionuclide angiocardiography examined before and after shunt operation in 8 patients. The results were as follows: 1) Of the 161 patients examined radionuclide angiocardiography, 98 were thought to have cardiac shunts: right to left shunt in 27, left to right shunt in 71. Of the 71 patients who had left to right shunt, 40 who were examined with both radionuclide angiocardiography and oxymetry had following congenital heart disease: VSD in 21, ASD in 9 and PDA in 10. 2) Comparison of Qp/Qs ratios obtained during radionuclide angiocardiography and oxymetry revealed good correlation (linear regression analysis yielded correlation coefficient of 0.80) in 32 patients whose Qp/Qs ratio obtained during oxymetry were below 3.0, but very poor correlation in 8 patients whose Qp/Qs ratios were above 3.0. 3) Radionuclide angiocardiography is a relatively safe and simple method in postoperative evaluation of patients with cardiac shunt.

  5. Ultravist in children's angiocardiography and angiography

    International Nuclear Information System (INIS)

    370 children, ranging from 1 day to 18 years of age, have underwent angiocardiography (285 children), cerebral angiography (36), abdominal (27) and peripheral angiography (22) with ultravist. The tolerance is excellent, there were no significant biological effects and allergic reactions. The quality of pictures is fairly good. Conclusively the use of ultravist is demanded for children. (author)

  6. Digital angiocardiography: Data volumes, archiving and feasibility

    International Nuclear Information System (INIS)

    Important advantages in patient medical care and scientific evaluation are to be expected with digital image documentation in angiocardiography. In addition to reduced radiation exposure throughout the examination the availability of optimal image quality is guaranteed on transportable media or over telecommunication networks. Simultaneously, significantly lower costs for storage media and archiving at minimum access times ranging from seconds to minutes are becoming a reality. Since documentation times of almost all examinations and interventions can be contained on a single CD-R, the relation 'one examination - one medium' can be maintained, which is a major advantage in daily practical application. The universal readability of the CD-R allows exchanging image data within the scope of international studies with simultaneous documentation of the examination parameters. (orig.)

  7. Diagnosis of isolated dextrocardia using angiocardiography or surgery

    Institute of Scientific and Technical Information of China (English)

    马宁; 蒋世良; 黄连军; 赵世华; 徐仲英; 凌坚; 郑宏

    2004-01-01

    Background Isolated dextrocardia is a rare phenomenon and usually associated with multiple cardiac anomalies. This study was to evaluate the accuracy of diagnosis of isolated dextrocardia by using angiocardiography and to compare it with the results of surgery.Methods The clinical data of 27 cases of congenital isolated dextrocardia were collected to understand the diagnostic approaches to the major cardiac anomalies. All cases underwent angiocardiography followed by palliative or curative surgery. The diagnosis was compared by angiocardiography relying on segmental analysis with the pathological features observed in surgery.Results The results of angiocardiography of 22 patients were the same as the pathological features observed druing surgery, including one case with congenital left ventricular diverticulum was inadvertently omitted in angiocardiograhy. There were significantly dissimilar diagnoses between angiocardiograhy and post-operation in 5 patients, including anatomical corrected transposition of great arteries misinterpreted as corrected transposition of the great arteries in 1, complete transposition of great arteries misinterpreted as corrected transposition of the great arteries in 1, single ventricle misinterpreted as double-outlet right ventricle in 1, and anatomical double-outlet left ventricle misinterpreted as corrected transposition of the great arteries in 2. Misdiagnostic rate of angiocardiograhy was almost 20%.Conclusions Angiocardiography is of great significance in the diagnosis and classification of isolated dextrocardia. However, because of the intricacy of cardiac anomalies of isolated dextrocardia, atrial angiography and double oblique projection are needed to improve the accuracy of diagnosis to support surgical treatments.

  8. Pulmonary blood volume measured by RI angiocardiography

    International Nuclear Information System (INIS)

    RI angiocardiography (RACG) was performed in 81 patients with heart disease without congestive heart failure at the time, and the results were compared between the groups with mitral valve disease and other diseases. Cardiac output (CO) and pulmonary mean transit time (PMTT) were compared with the results from the dye dilution method in the same patients. PMTT directly measured by RACG was also compared with the peak to peak time (P-PT). P-PT was expressed as the distance from the right to the left peak time in radiocardiography (RCG). There were good correlations between the CO and PMTT obtained from the RI method and those of the dye dilution method (r = 0.90, r = 0.84). The ralationship between PMTT and P-PT in mitral valve disease was different from that of other diseases. The average value of PMTT was 5.2 +- 1.0 seconds, and pulmonary blood volume (PBV) was 315 +- 57 ml/m2 in the control group. The PBV values were markedly increased in patients with mitral stenosis (558 +- 132 ml/m2) and mitral regurgitation (444 +- 119 ml/m2), and were slightly increased in aortic valve disease, congenital shunt disease and cardiomyopathy. The patients with ischemic heart disease had normal PBV. In mitral valve disease, the direct method using PMTT of RACG is more accurate than the presumption method using P-PT of RCG. The determination of PBV by this method is very important to observe hemodynamic states in mitral valve disease. (J.P.N.)

  9. Diagnostic Validity of RI Angiocardiography in Cardiac Diseases

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Kwan Yop; Koh, Chang Soon; Lee, Mun Ho [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    1972-09-15

    The employment of gamma-ray scintillation camera with the use of short-lived radioisotopic pharmaceuticals, such as {sup 99m}Tc sodium pertechnetate, have enabled us to perform RI (radioisotopic) angiocardiography. Although conventional cardiac catheterization or angiocardiography using contrast media have been an important diagnostic tool, they may carry some risks or serious complications. The author investigated on RI angiocardiography in twelve normal and twenty five patients with cardiovascular diseases in an effort to evaluate its diagnostic value. The results obtained with this study are as follows; l. In normal subjects, the scintillation camera transit time of arm-to-right heart was found to be 2.1+-0.67 seconds, right heart-to-lung 1.5+-0.40 seconds and lung-to-left heart 3.5+-0.86 seconds. 2. Transformation or displacement of the heart and the great vessel are easily discriminated by RI angiocardiography. Both in the cases with tricuspid atresia and tetralogy of Fallot, ventricular septal defects are well recognized by sequential RI angiocardiography. 3. It is also helpful in determining the site and extent of obstruction, and estimating the postoperative course both in the cases with superior vena cava syndrome and pulmonary stenosis. 4. Pericarditis with effusion is readily diagnosed by RI angiocardiogram showing characteristic 'dead space' between intracardiac and intrapulmonary radioactivity. 5. It was found that the diagnostic accuracy of this study was 78.4%. It is concluded that above results obtained are useful and accurate enough for the diagnostic screening method for clinical practice.

  10. Diagnostic Validity of RI Angiocardiography in Cardiac Diseases

    International Nuclear Information System (INIS)

    The employment of gamma-ray scintillation camera with the use of short-lived radioisotopic pharmaceuticals, such as 99mTc sodium pertechnetate, have enabled us to perform RI (radioisotopic) angiocardiography. Although conventional cardiac catheterization or angiocardiography using contrast media have been an important diagnostic tool, they may carry some risks or serious complications. The author investigated on RI angiocardiography in twelve normal and twenty five patients with cardiovascular diseases in an effort to evaluate its diagnostic value. The results obtained with this study are as follows; l. In normal subjects, the scintillation camera transit time of arm-to-right heart was found to be 2.1±0.67 seconds, right heart-to-lung 1.5±0.40 seconds and lung-to-left heart 3.5±0.86 seconds. 2. Transformation or displacement of the heart and the great vessel are easily discriminated by RI angiocardiography. Both in the cases with tricuspid atresia and tetralogy of Fallot, ventricular septal defects are well recognized by sequential RI angiocardiography. 3. It is also helpful in determining the site and extent of obstruction, and estimating the postoperative course both in the cases with superior vena cava syndrome and pulmonary stenosis. 4. Pericarditis with effusion is readily diagnosed by RI angiocardiogram showing characteristic 'dead space' between intracardiac and intrapulmonary radioactivity. 5. It was found that the diagnostic accuracy of this study was 78.4%. It is concluded that above results obtained are useful and accurate enough for the diagnostic screening method for clinical practice.

  11. Radiation induced chromosomal aberrations after cardiac catheterization and angiocardiography

    International Nuclear Information System (INIS)

    The relationship between the radiation doses and the chromosomal aberrations of peripheral lymphocytes was studied in patients under-going catheterization with or without angiocardiography. The radiation doses were estimated and chromosomal aberration analyses were carried out in 17 cases. They consisted of 10 males and 7 females at the age of 4 to 26 years with an average of 14 years. Doses in the chest and gonadal regions were measured with calibrated thermoluminescent dosimeters. Peripheral blood samples were taken immediately before and after the diagnostic procedure for chromosome analyses. Results showed that the average doses in the gonad region during cardiac catheterization with and without angiocardiography were 2.4 and 0.83 kC/kg respectively, while those in the chest region were as high as 0.93 and 0.54 kC/kg respectively. The chromosome aberration rate in both groups were significantly higher (2.75-3.33%) than the control value (0.22-0.75%) which was determined before X ray examination. No statistically significant difference of chromosome aberration yield was found between the two groups with and without angiocardiography

  12. Evaluation of radioisotopic angiocardiography in patent ductus arteriosus

    International Nuclear Information System (INIS)

    Dynamic images and curves obtained from radioisotopic angiocardiography (RI-ACG) using video recording system were studied in 5 patients with patent ductus arteriosus (PDA), to disclose any characteristic findings of PDA on this radioisotopic examination. And, the examination was evaluated with referance to diagnosis and assessment of status of PDA, comparing with other radiological examinations including angiocardiography and catheterization. Both the dynamic images and the dynamic curves of RI-ACG showed some characteristic findings of PDA, which was considered to be valuable to differentiate the intracardiac left to right shunt in atrial or ventricular septal defect. It was very characteristic of PDA that dynamic images showed regional dilution and recirculation patterns in the region of the main pulmonary artery to its periphery, and dynamic curves presented shunt waves on the descending limbs of the first circulation waves of both the pulmonary and the left ventricular region of interest. The Degrees of appearance of these characteristic findings showed a tendency to well correlate with the value of the left to right shunt fraction calculated by cathetelization technique. On the other hand, RI-ACG showed useful findings to diagnose pulmonary hypertension or heart failure associated with PDA. And, RI-ACG was very useful to detect an abrupt change of the central circulation dynamics in a patient with PDA, in whom continuous murmur characteristic of PDA desappeared intermittently. (author)

  13. Assessment of poststress left ventricular ejection fraction by gated SPECT: comparison with equilibrium radionuclide angiocardiography

    International Nuclear Information System (INIS)

    We compared left ventricular (LV) ejection fraction obtained by gated SPECT with that obtained by equilibrium radionuclide angiocardiography in a large cohort of patients. Within 1 week, 514 subjects with suspected or known coronary artery disease underwent same-day stress-rest 99mTc-sestamibi gated SPECT and radionuclide angiocardiography. For both studies, data were acquired 30 min after completion of exercise and after 3 h rest. In the overall study population, a good correlation between ejection fraction measured by gated SPECT and by radionuclide angiocardiography was observed at rest (r=0.82, p<0.0001) and after stress (r=0.83, p<0.0001). In Bland-Altman analysis, the mean differences in ejection fraction (radionuclide angiocardiography minus gated SPECT) were -0.6% at rest and 1.7% after stress. In subjects with normal perfusion (n=362), a good correlation between ejection fraction measured by gated SPECT and by radionuclide angiocardiography was observed at rest (r=0.72, p<0.0001) and after stress (r=0.70, p<0.0001) and the mean differences in ejection fraction were -0.9% at rest and 1.4% after stress. Also in patients with abnormal perfusion (n=152), a good correlation between the two techniques was observed both at rest (r=0.89, p<0.0001) and after stress (r=0.90, p<0.0001) and the mean differences in ejection fraction were 0.1% at rest and 2.5% after stress. In a large study population, a good agreement was observed in the evaluation of LV ejection fraction between gated SPECT and radionuclide angiocardiography. However, in patients with perfusion abnormalities, a slight underestimation in poststress LV ejection fraction was observed using gated SPECT as compared to equilibrium radionuclide angiocardiography. (orig.)

  14. Detection of right atrial hemangiosarcoma using nonselective angiocardiography in a dog

    International Nuclear Information System (INIS)

    Cardiac hemangiosarcoma has been reported to occur most often in older, large breeds of dogs (1). Clinical signs are variable, but approximately 50% of the reported cases have signs referable to cardiac disease (2). Antemortem diagnostic aids for the detection of space occupying cardiac masses include radiography (2, 3), pneumopericardiography (4), angiocardiography (3-8), and echocardiography (1, 3, 4, 8-10). However, a definitive diagnosis of cardiac hemangiosarcoma is dependent upon pathological confirmation (10). In the following report, we discuss the use of non-selective angiocardiography as an effective diagnostic procedure in a dog with right atrial hemangiosarcoma

  15. Progressive massive fibrosis developing after brief coal dust exposure: evaluation with CT scanning and radionuclide angiocardiography.

    Science.gov (United States)

    Williams, T J; Raval, B; Ahmad, D

    1980-01-01

    Two patients are described who developed progressive massive fibrosis (PMF) after exposure to coal dust for only four and seven years, respectively, in Belgian coal mines in the post-war period. It seems likely from consideration of epidemiological data that these men were exposed to massive concentrations of coal dust during their time in the mines. In one patient in a computerized tomography scan clearly showed the extent of the PMF and brought out the degree of calcification in the center of the masses. Radionuclide angiocardiographic evaluation showed depressed right ventricular function which is probably a result of pulmonary hypertension, and also showed marked distortion of the pulmonary vascular bed. It is believed that these are the first reported instances of CT scanning and radionuclide angiocardiography in this condition. PMID:7354409

  16. Measurement of right ventricular volumes from ECG-gated steady-state krypton-81m angiocardiography

    Energy Technology Data Exchange (ETDEWEB)

    Franken, P.R.; Mols, P.; Delcourt, E.; Dobbeleir, A.; Georges, B.; Ham, H.R.

    1987-05-01

    The physical characteristics of krypton-81m makes it particularly suited for the study of right ventricular function, but its ultrashort half-life (13.3 s) precludes in vitro measurements of blood pool specific activity needed for count based determination of ventricular volumes. A combined geometric count based method was developed to measure absolute right ventricular volumes during steady state krypton-81 m angiocardiography: background corrected ventricular count rates were converted to volumes using a count to volume calibration factor calculated in an 'internal reference ROI' located in the right ventricular outflow tract. Stroke volumes calculated with this method were shown to be comparable to thermodilution determined stroke volumes and the ability of the method to monitor changes in right ventricular volumes was demonstrated during intervention studies.

  17. Basic studies on the estimation of the capacitance of human pulmonary 'venous' system using radionuclide angiocardiography

    International Nuclear Information System (INIS)

    To establish the methodology to assess the capacitance of human pulmonary 'venous' system, using radionuclide angiocardiography and passive leg elevation, some basic aspects of the method were investigated. The pulmonary 'venous' system consisted of pulmonary veins and the left atrium. A short segment of the volume-pressure curve in human pulmonary 'venous' system was obtained as a line connecting the 2 points. (1) Pulmonary 'venous' volume-mean pulmonary capillary wedge pressure plot (P 'V' V-PCW plot) in supine position, where P 'V' V=0.7 x PBV. Pulmonary blood volume (PBV) was obtained by radionuclide angiocardiography, while mean pulmonary capillary wedge pressure (PCW) was simultaneously recorded by a floating catheter. (2) ΔP 'V' V-ΔPCW relation where ΔP 'V' V=0.8 x ΔPBV. Increment of the pulmonary blood volume (ΔPBV) during passive elevation of legs was measured from the baseline PBV and the percentage increase in the radioactivity over the right anterior chest during the leg elevation, after correction for (a) radioactivity from chest wall origin, and for (b) attenuation of the radioactive beams by the lung and the anterior chest wall. ΔPCW was the increase in PCW during leg elevation. The present study focussed on the details of the two corrections, (a) and (b), using, in parts, mechanical models. The present study also focussed on the reproducibility of the ΔP 'V' V, ΔPCW and Cp'v' (compliance of the pulmonary 'venous' system). The coefficient of variation was ±23% in ΔP 'V' V, ±18% in ΔPCW and ±18% in Cp'v', indicating a fair degree of reproducibility. (author)

  18. Analysis of end-systolic pressure-volume relation by gated radionuclide angiocardiography

    International Nuclear Information System (INIS)

    Left ventricular end-systolic pressure-volume relation has been proved experimentally to b e an useful index of left ventricular contractility relatively independent of preload or afterload. But less clinical application has been reported because of its invasive nature, and we evaluated this relationship non-invasively using gated radionuclide angiocardiography as volume determination and cuff sphyngomanometer in the arm as pressure measurement. Gated equilibrium blood pool scintigrams were obtained at rest and during intravenous infusion of angiotensin or nitrate. Ventricular volumes were derived from ventricular activity and peripheral blood volume and activity. The peak systolic pressure (PSP) by cuff method to end-systolic volume index (ESVI) relations showed good linearity (r gt .930 in 84% of consecutive 50 cases) and were gentler in the groups with more impaired left ventricular function. Emax was related exponentially to ejection fraction (EF) and hyperbolically to end-diastolic volume index. The dead volume (VoI) was unfixed and fell into positive or negative value, and was not related to EF under control condition. PSP/ESVI in each loading condition was less variable with the alteration of blood pressure than EF. The linear relation was found between PSP/ESVI under control condition and Emax (PSP/ESVI = 0.651.Emax + 0.958, r = 0.841, p lt .001). Thus in measuring ventricular volume, gated radionuclide angiocardiography is a non-invasive method less affected by the geometry of the left ventricle. Non-invasive determination of end-systolic pressure-volume relation using the volume by radionuclide and the blood pressure by cuff method is clinically useful in the assessment of left ventricular contractility. (author)

  19. Localization of left-to-right shunts by radionuclide angiocardiography (RAC)

    International Nuclear Information System (INIS)

    A method to detect, quantify and localize left-to-right shunts by computer analysis of radionuclide angiocardiography has been developed. Thirty-eight patients were studied, 28 with left-to-right shunts and 10 without any evidence of cardiovascular disease. Twelve cases of ventricular septal defect were localized accurately, three pre-operatively and nine post-operatively with residual left-to-right shunt. Eight patients had shunts localized at the atrial level and confirmed by cardiac catheterization and surgery. In one patient valvular pulmonic stenosis was confirmed by absence of any left-to-right shunt whatsoever. Three patients appeared to have sufficiently specific streaming of the left-to-right shunt that the shunt was localized at the next downstream level. A patient in whom we diagnosed ASD went to surgery directly without the need for cardiac catheterization. Multiple studies can be done pre-operatively and post-operatively, for diagnostic purposes, or to follow the patient's progress. (author)

  20. Right and left ventricular ejection fraction at rest and during exercise assessed with radionuclide angiocardiography

    International Nuclear Information System (INIS)

    Right (RVEF) and left ventricular ejection fraction (LVEF) assessed with radionuclide angiocardiography were compared to simultaneously obtained catheterization results at rest and during exercise in patients with pulmonary hypertension and ischemic heart disease. Blood pool imaging was performed with red blood cells (RBC) labelled with 99Tcsup(m) in vivo as this method gave more stable 99Tcsup(m) levels in blood compared to 99Tcsup(m)-labelled human serum albumin and because it was more convenient than labelling RBC in vitro. RVEF measured with first pass (FP) technique and equilibrium (EQ) technique correlated well at rest, r = 0.86, and during exercise, r = 0.91. The FP technique had the best reproducibility and reference values at rest were 49+-5 per cent increasing with exercise. When 99Tcsup(m) and 133Xe were compared to assess RVEF with FP technique, the correlation was good, r = 0.88. LVEF assessed with EQ technique and a fixed end-diastolic region of interest was very reproducible at rest and during exercise; reference values at rest were 56+-8 per cent increasing with exercise. In 10 patients with pulmonary hypertension significant negative correlations were found between RVEF assessed with FP technique and pressures in pulmonary artery and right atrium. Abnormal RVEF was found in all patients with right ventricular disfunction. In 22 patients with recent myocardial infarction measurements of LVEF detected left ventricular disfunction better than did measurement of pulmonary artery diastolic pressure. During effort angina in another 10 patients all had abnormal LVEF and abnormal hemodynamics. By combining ejection fraction and stroke volume, ventricular volumes were calculated at rest and during exercise. (author)

  1. Left ventricular ejection fraction in the normal horse determined by first-pass nuclear angiocardiography

    International Nuclear Information System (INIS)

    A method to perform first-pass nuclear angiocardiography (FPNA) in the conscious, standing horse is proposed. Technetium −99m (0.75–1.0 mCi per 5 kg body weight) is injected as a bolus into the peripheral venous circulation. The passage of the radioactive bolus is recorded in listmode format using a dedicated nuclear medicine computer and a gamma camera. A semiautomatic equine cardiac computer program to calculate left ventricular ejection fraction (LVEF) is described. Effects of region-of-interest selection, background correction, portion of levophase analyzed, and sampling rate on ejection fraction values are discussed. Mean LVEF determined for a group of 13 normal horses using separate end-systolic and end-diastolic LV regions of interest for the middle three levophase beats and background correction was 71%±5%. Additional LV parameters recorded were LV ejection time, 429±78 milliseconds; LV ejection rate, −1.9±.5 midsytolic volumes per second; LV filling time, 238±33 milliseconds; and LV filling rate, 2.4±0.5 midfast filling volumes per second. LVEF determinations were repeated three times in four horses to determine reproducibility of the method. Results were independently determined for three horses by four persons to assess interobserver error in processing data. Paired FPNA and electrical conductivity (EC) studies were performed on four horses to determine correlation of the two methods (FPNA = 1.16 EC+9.16, R = 0.75). FPNA is a safe and reproducible method to measure LVEF in the horse. Additional valuable information regarding cardiac function can be easily obtained using this technique

  2. Non-invasive estimation of the human pulmonary blood volume with gamma camera and RI-angiocardiography

    International Nuclear Information System (INIS)

    A new, non-invasive method for the estimation of the human pulmonary blood volume (PBV), existing between the pulmonary artery bifurcation (PAB) and the left atrium (LA), has been developed in this laboratory, in the form of PBV = PPT sub(RCG) x 0.77 x CO, equation (6), given in Appendix. This was an extension of the classical Stewart-Hamilton method of indicator dilution, applied to radioisotope angiocardiography. Using a gamma-camera, the radio-isotope (99 m Tc-albumin) dilution curves were recorded externally at the region of PAB, LA and LV (left ventricle), among other things, in human subjects in supine position. The mean transit time (MTT) was determined for each region, and the difference in MTT, e.g., ΔMTT sub(PAB-LA), was measured. We calculated PBV between PAB and LA as PBV = ΔMTT sub(PAB-LA) x CO, equation (1) given in Appendix. Empirical time relations between ΔMTT sub(PAB-LA) and PPT sub(RCG) were examined in mechanical models and human subjects, through several steps represented by equations (2) to (5), given in Appendix, and our tentatively final formula was equation (6). The values of PBV estimated in this way were in good agreement with those of PBV measured invasively in the past, using two injection sites (PA and LA) and one sampling site (artery). (author)

  3. Non-invasive assessment of left ventricular contractility from end-systolic pressure-volume relation (E(max)) determined by gated radionuclide angiocardiography

    International Nuclear Information System (INIS)

    Left ventricular end-systolic pressure-volume relation has been shown experimentally to be an useful index of left ventricular contractility relatively independent of preload or afterload. But the clinical application has been reported less frequently because of the invasiveness in the measurement of ventricular volume and simultaneous intraventricular pressure. We evaluated this relationship using non-invasive method such as the volume determination by gated radionuclide angiocartiography and the pressure measurement by cuff sphyngomanometer in arm. In measuring ventricular volume, gated radionuclide angiocardiography is a non-invasive method less affected by the geometry of left ventricle. Using the volume by radionuclide and the blood pressure by cuff, non-invasive determination of endsystolic pressure-volume relation provides much clinical usefulness in the assessment of left ventricular contractility

  4. Right ventricular ejection fraction: Comparison of technetium-99m first pass technique and ECG-gated steady state krypton-81m angiocardiography

    International Nuclear Information System (INIS)

    Right ventricular ejection fraction (RVEF) calculated from ECG-gated steady-state 81mKr angiocardiography and from 99mTc first-pass studies were compared in 30 patients using a digital, single crystal, gamma-camera. Despite the two entirely different approaches RVEF valves obtained by the two methods were comparable (r=0.97): the mean absolute difference between the two techniques was 2.5%+/-1.5% and the largest observed absolute difference was 5%. In the absence of an accepted reference method for measuring RVEF, this close correlation provides indirect validation of both techniques. The choice of method will therefore depend on several factors, including radiotracer availability, the characteristics of the gamma-camera and the protocol of clincal investigation. (orig.)

  5. Cine MRI in functional and morphological examination of the heart after myocardial infarction. Comparison to angiocardiography, two-dimensional echocardiography, radionuclide ventriculography and enzymatical estimation of infarct size

    International Nuclear Information System (INIS)

    61 patients (17 women, 44 men, 36-83 years, 32 with anterior, 29 with posterior wall infarction) received Cine-MRI in the true long and short axis of the heart and two-dimensional echocardiography one and 4 weeks post infarction. Two-level angiocardiography (ACG) and radionuclide ventriculography (RNV) were performed 4 weeks p.i. The size of myocardial infarction was determined enzymatically with the CK integral method. Left ventricular volume indices (EDVI, ESVI, SVI), ejection fraction (EF) and infarction weight (IW) were compared. Excellent correlations existed between Cine-MRI in the long and short axis for the volume indices and EF. Between Cine-MRI in the short axis and ACG all correlations were excellent aswell. They were significantly less satisfactory between Cine-MRI and 2DE due to the inhomogeneity of echo quality. Cine-MRI and RNV produced similar EF results (r=0.884), and a comparison of IW in Cine-MRI and CK integral method also showed a good correspondence (r=0.967). (orig./MG)

  6. Evaluation of ECG gated RI angiocardiography for measurement of left ventricular function and its clinical application. Comparison with contrast cineangiography and application to pre and post treatment observation

    Energy Technology Data Exchange (ETDEWEB)

    Iida, Shun; Morishita, Takashi (Toho Univ., Tokyo (Japan). School of Medicine)

    1983-03-01

    Cardiac function was examined by the radio-isotope (RI) angiocardiography method in 57 patients with various heart diseases and 8 healthy subjects. In addition, the cardiac catheter examination was performed for comparison in 49 of the heart disease patients. After sup(99m)Tc-HSA was injected into the right antecubital vein by flush method, the electro-cardiogram was synchronized to obtain data. The data were analyzed with a computer and 9 parameters of the cardiac function were calculated: cardiac output (CO), ejection fraction (EF), pre-ejection period (PEP), left ventricular ejection time (LVET), left ventricular rapid filling time (LVRFT), left ventricular slow filling time (LVSFT), EF/LVET, EF/LVDT, and left ventricular end diastolic volume (LVEDV). When the RI method was compared with the cineangiogram, a significant correlation was found in all parameters: r = 0.728 (p < 0.01) in CO, r = 0.89 (p < 0.01) in EF, r = 0.825 (p < 0.001) in LVEDV, etc. Moreover, it is suggested that this method can be repeatedly applied to investigate the progress following an operation of the heart and the alteration of essential hypertension through drug treatment.

  7. Application of quantitative radioisotope angiocardiography (QRA) with transesophageal left atrium pacing for the assessment of the effect of sustained-release verapamil on left ventricular function

    International Nuclear Information System (INIS)

    The aim of the study was a comparative analysis of global and regional left ventricular function indices in patients with chronic coronary artery disease without myocardial infarction before and after one-month-long treatment with sustained-release verapamil (SR verapamil). The studies were performed in 20 patients with significant changes in coronarography. Left ventricular function was assessed by means of quantitative radioisotope angiocardiography (QRA) at rest, during, and directly after fast transoesophageal left atrium pacing. Before administration of the drug the left ventricular function parameters at rest were normal. At the peak and directly after the pacing the mean values decreased significantly of the global indices of ejection phase. SR verapamil at rest improved significantly the parameters of left ventricular filling phase but deteriorated the parameters of ejection phase. In conditions of transient myocardial ischaemia (during and directly after pacing) the drug decreased significantly the extent of reversible ischaemic left ventricular dysfunction. However, the regional indices of both cardiac cycle phases were not decreased during all stages of left ventricular function study in the patients before and after the treatment with SR verapamil

  8. Gold-195m, a new generator-produced short-lived radionuclide for sequential assessment of ventricular performance by first pass radionuclide angiocardiography

    International Nuclear Information System (INIS)

    The feasibility of performing rapid sequential first pass radionuclide angiocardiography using a new short-lived radiotracer, gold-195m (195/sup m/Au) half-life 30.5 seconds) was evaluated. This radionuclide emits a 262 keV gamma ray and is the daughter of mercury-195 (195/sup m/Hg) (half-life 41.6 hours). The prototype table top 195/sup m/Hg/195/sup m/Au generator produced 20 to 25 mCi of 195/sup m/Au in 2 ml of eluate (yield of 40 percent). Four dogs each had 15 to 20 sequential first pass studies performed with 195/sup m/Hg at 3 to 10 minute intervals using a computerized multicrystal gamma camera. During the left ventricular phase, 160,000 to 190,000 counts/s were acquired. The end-diastolic left ventricular region of interest contained 3000 to 6000 counts (background- and decay-corrected). Multiple reproducible values for left ventricular ejection fraction were obtained during stable conditions. During infusion of isoproterenol, rapid increase of left ventricular ejection fraction was demonstrated. Excellent agreement was observed between studies performed with technetium-99m diethylenetriaminepentaacetic acid (99/sup m/Tc-DTPA) and 195/sup m/Au. This new short-lived radiotracer makes possible rapid sequential assessments of ventricular function at greatly reduced patient exposure to radiation

  9. /sup 195m/Au, a new generator-produced short-lived radionuclide for sequential assessment of ventricular performance by first pass radionuclide angiocardiography

    International Nuclear Information System (INIS)

    The feasibility of performing rapid sequential first pass radionuclide angiocardiography using a new short-lived radiotracer, (195mAu) half-life 30.5 seconds) was evaluated. This radionuclide emits a 262 keV gamma ray and is the daughter of (195mHg) (half-life 41.6 hours). The prototype tabletop 195mHg/195mAu generator produced 20 to 25 mCi of 195mAu in 2 ml of eluate (yield of 40 percent). The breakthrough of 195mHg in the eluate was 0.02 percent of the amount of 195mHg in the generator. The eluate contained 20 microCi of 195mHg per study, resulting in an estimated human radiation dose of 0.007 rad/study to the whole body and 0.34 rad/study to the kidney. Four dogs each had 15 to 20 sequential first pass studies performed with 1195mHg at 3 to 10 minute intervals using a computerized multicrystal gamma camera. During the left ventricular phase, 160,000 to 190,000 counts/s were acquired. The end-diastolic left ventricular region of interest contained 3,000 to 6,000 counts (background- and decay-corrected). Multiple reproducible values for left ventricular ejection fraction were obtained during stable conditions. The mean (+/- standard deviation) interstudy variability was 4 +/- 2 percent. During infusion of isoproterenol, rapid increase of left ventricular ejection fraction was demonstrated. Excellent agreement was observed between studies performed with /sup 99m/Tc-DTPA) and 195mAu. The mean interstudy difference was 4 +/- 3 percent. Thus, sufficiently high yield and dose are obtained from the 195mHg/195mAu generator for reliable high count rate first pass determination of left ventricular ejection fraction. This new short-lived radiotracer makes possible rapid sequential assessments of ventricular function at greatly reduced patient exposure to radiation

  10. Caudal Anaesthesia in Cardiac Catheterization and Angiocardiography%小儿骶管麻醉用于心导管和心血管造影术

    Institute of Scientific and Technical Information of China (English)

    袁惠芬; 郝复; 徐金龙; 陈文英; 汤卫平; 康健; 肖菡

    1987-01-01

    本文报告骶管麻醉在小儿先天性心脏病心导管和心血管造影术中的应用.骶管麻醉组44例,静脉麻醉12例.结果,骶管麻醉组并发症明显低于单纯静脉麻醉.骶管麻醉不仅有助于导管操作和造影时体位固定,且有利于代谢和血流动力的稳定.%This paper reports the use of caudal anaesthesia in cardiac catheterization and angiocardiaography on children with congenital heart diseases,and the comparison between it and the intravenous anaesthesia on the basis of their angiocardiographic data.In the group of caudal anaesthesia(44 cases),1-1.75% procaine and 0.1-0.15% dicaine solution with adrenaline(1ml /Kg body weight)were given.Intermittent increments of Valium or Ketamine was administered when necessary.Intravenous anaesthesia was applied to 12 cases(Group Ⅱ)with Ketamine and α-hydroxybutyrat or Valium.Results:43.18% of the patients in Group Ⅰ did not require increments of intravenous anaesthetics,but 13 cases Ketamine was given(dosage:0.85-0.49 mg/kg/hr).Ketamine was administered unexceptionally in GroupⅡ with a dosage of 1.61-0.84 mg/kg/hr.There was significant difference between the two groups in the dosage of Ketamie(p<0.02).The caudal anaesthsia group had a much lower occurrence of complications as compared with those who received intravenous anaesthesia alone.The authors considered that caudal anaesthesia is better than intravenous anaethsia in angiocardiography in pediatric cases,for it keeps the pateint well immobulized and makes catheter manipulation easier,and also provides a stable metabolic and haemodynamic condition.

  11. Radionuclide angiocardiography in the normal dog: equilibrium studies

    International Nuclear Information System (INIS)

    Equilibrium radionuclide ventriculography was applied in 27 healthy anaesthetised dogs after labelling the blood pool with 99mTc, using a gamma camera with a computer on-line. Quantitative analysis of the calibrated ventriculogram provided the following left ventricular parameters: the end diastolic volume (EDV), the ejection fraction (EF), the possible degree of regurgitation and as velocity indices the peak ejection and peak refilling rates (PER and PRR). Averaged results were: EDV 1.8ml kg-1; EF 0.59; PER 4.3 EDV s-1; PRR 3.75 EDV s-1. Visual inspection of the camera images may reveal abnormal wall motions and dilatation of heart chambers. (author)

  12. Thoraco-Omphalopagus: Importance of angiocardiography for clarification of operability

    International Nuclear Information System (INIS)

    The article reports on a case of thorako-omphalopagus with conjoinment from the sternum to the umbilical region. Radiological and especially angiocardiographic examination revealed considerable fusion and complex malformation of the hearts of Siamese twins. This specific diagnosis proved the inoperability of the otherwise largely regularly developed children who died on the sixth day of their life. (orig.)

  13. Clinical evaluation of ultravist use in patients with coronary arterial diseases and in children during angiocardiography

    International Nuclear Information System (INIS)

    Evaluation of ultravist contrast media, applied in coronary arterial diagnostics is performed. Frequency of side effects, impact of the preparation on changes in basic homodynamic indices, ECG and certain blood indices are studied. The data obtained testify to its good tolerance and safety by application to seriously diseased patients and especially in pediatric radiology. 15 refs

  14. Assessment of cardiac function by radionuclide angiocardiography in children with cardiomyopathy

    International Nuclear Information System (INIS)

    Radionuclide angiography was performed in four children, each having dilated cardiomyopathy (DCM), hypertrophic nonobstructive cardiomyopathy (HCM), hypertrophic obstructive cardiomyopathy (HOCM), or restrictive cardiomyopathy (RCM), whose ages ranged from 5 to 8 years. The peak to peak time of flow from the right to left ventricle, which was corrected by heart rate, was prolonged in all the patients. Left ventricular ejection fraction was low in the DCM patient, and high in the HOCM patient. In the DCM patient, both peak ejection rate and peak filling rate of the left ventricle were low. Two patients with either DCM or HOCM had the prolongation of percent duration to peak filling rate, as opposed to the RCM patient having short percent duration. In the RCM patient, right ventricular ejection fraction was low, and time-volume curve showed rapid filling during early diastole. Radionuclide angiography is recommended as a noninvasive method of evaluating cardiac functional characteristics for various types of myocardiopathy. (Namekawa, K.)

  15. Activation of blood clotting and fibrinolysis in angiocardiography with ionic and non-ionic contrast medium

    International Nuclear Information System (INIS)

    Purpose: To study the effects of a ionic (amidotrizoate) and a nonionic X-ray contrast medium (iopromid) during routine levocardiography and coronary angiography, we employed assays that detect reaction products of thrombin and plasmin to assess the activation of the haemostatic system. Methods: Subsequent to informed consent, 20 patients were randomly assigned to receive either amidotrizoate or iopromid during standard levocardiography and coronary angiography in a double-blind comparative study. Groups were comparable in respect of age, weight, sex and severity of the disease. No anticoagulation was provided. Coronary angiography was performed according to a standardised protocol. Consumption of contrast media and duration of the examination were comparable in both groups. Results: Thrombin generation (F.1+2) and thrombin activity (TAT) were higher with the ionic contrast medium but did not attain statistical significance. Fibrin generation and degradation as expressed by D-dimer fibrin split products was significantly increased in patients who had been receiving amidotrizoate (p<0,05, U-Test). Conclusion: The non-ionic X-ray contrast medium induced significantly less haemostatic activation in vivo than did the ionic medium amidotrizoate. These data suggest that earlier in vitro observations of more pronounced anticoagulant effects of ionic X-ray contrast media are of limited significance for the evaluation of in vivo effects of X-ray contrast media on haemostatic function. (orig.)

  16. Determination of the left ventricular volumina by computerized tomography, as compared to laevo-angiocardiography

    International Nuclear Information System (INIS)

    Cardiac CT, both prior to and after contrast medium injection, according to the current knowledge is a good and informative method of non-invasive volume measurements of the end-diastolic volume of the left ventricle, using the two-axial technique. The correlations made have shown that the evaluation model chosen will allow statistically satisfactory results to be obtained even by non-experienced analysts, and that it hence is a reliable and reproducible method. The evaluation employing planimetry consistently yields results exceeding those of cardiac catheterisation by up to 20 p.c. This difference is even higher in case of cardiomegaly or cardiac wall hypertrophy. The error sources inherent in this method still make end-systolic volume determination less satisfactory, although the results indicate possible ways of optimization. As the determination of stroke volume and output fraction is based on the end-systolic volume measurement, the error sources of this part of the method are taken into account in the evaluation. This explains the low linear correlation which, according to the current state of knowledge, would characterise the method as non-acceptable. Breaking down the case material into various groups of disease results in differently high correlations, due to the different configurations presented by the left ventricle as a consequence of various diseases. The best agreement is obtained in the group of patients suffering from cardiomyopathy. (orig./MG)

  17. A fully automated determination of the left ventricular region of interest in nuclear angiocardiography

    International Nuclear Information System (INIS)

    The precise delineation of the left ventricular projection area is an essential part in the quantitative analysis of nuclear angiocardiograms. We have devised an algorithm that permits automation of this step, based on a one-dimensional Laplace operator whose kernel is 2, 2, -2, -4, -2, 2, 2. The operator characteristically enhances 'valleys' more than edges and, therefore, favors septal and the valve plane detection. The operator is applied vertically, horizontally, and along both diagonals. Each pass is immediately followed by a local maximum search during which the image resulting from the Laplacian operator is reduced to a binary one, with zeros every where except where a local maximum was found along the path of the operator. This resultant image yields a closed 'edge' around the left ventricle, even though many structures outside the left ventricle are also delineated. However, the centroid of the ventricle is defined from functional criteria and the region of interest is defined from centroid to first edge. The method has been applied to first-pass and gated studies in anterior and 450 left anterior oblique views. In 100 successive cases the ejection fraction obtained automatically was compared to the manual result. (orig./MG)

  18. Activation of blood clotting and fibrinolysis in angiocardiography with ionic and non-ionic contrast medium; Aktivierung von Blutgerinnung und Fibrinolyse nach Angiokardiographie mit ionischem und nichtionischem Kontrastmittel

    Energy Technology Data Exchange (ETDEWEB)

    Winkler, U.H. [Gerinnungsphysiologisches Lab., Zentrum fuer Frauenheilkunde, Universitaetsklinikum Essen (Germany); Park, J.W. [Herz-Zentrum Kaiser-Wilhelm-Krankenhaus, Duisburg (Germany); Weber, S. [Schering AG, Geschaeftsbereich Deutschland, Berlin (Germany); Kothe, A. [Gerinnungsphysiologisches Lab., Zentrum fuer Frauenheilkunde, Universitaetsklinikum Essen (Germany); Schnitker, J. [Inst. fuer Angewandte Statistik GmbH, Bielefeld (Germany); Behrends-Steins, B. [Schering AG, Geschaeftsbereich Deutschland, Berlin (Germany); Albring, M. [Schering AG, Geschaeftsbereich Deutschland, Berlin (Germany)

    1997-06-01

    Purpose: To study the effects of a ionic (amidotrizoate) and a nonionic X-ray contrast medium (iopromid) during routine levocardiography and coronary angiography, we employed assays that detect reaction products of thrombin and plasmin to assess the activation of the haemostatic system. Methods: Subsequent to informed consent, 20 patients were randomly assigned to receive either amidotrizoate or iopromid during standard levocardiography and coronary angiography in a double-blind comparative study. Groups were comparable in respect of age, weight, sex and severity of the disease. No anticoagulation was provided. Coronary angiography was performed according to a standardised protocol. Consumption of contrast media and duration of the examination were comparable in both groups. Results: Thrombin generation (F.1+2) and thrombin activity (TAT) were higher with the ionic contrast medium but did not attain statistical significance. Fibrin generation and degradation as expressed by D-dimer fibrin split products was significantly increased in patients who had been receiving amidotrizoate (p<0,05, U-Test). Conclusion: The non-ionic X-ray contrast medium induced significantly less haemostatic activation in vivo than did the ionic medium amidotrizoate. These data suggest that earlier in vitro observations of more pronounced anticoagulant effects of ionic X-ray contrast media are of limited significance for the evaluation of in vivo effects of X-ray contrast media on haemostatic function. (orig.) [Deutsch] Ziel: Bestimmung der Aktivitaet des haemostatischen Systems in vivo nach Gabe von ionischem und nichtionischem Roentgenkontrastmittel in der Angiokardiographie. Material und Methoden: In eine randomisierte doppelblinde Vergleichsstudie mit den Kontrastmitteln Amidotrizoat und Iopromid wurden 20 Patienten (10 pro Gruppe) einbezogen. Bei der aus medizinischen Gruenden indizierten Angiokardiographie wurden 5 repraesentative Reaktionsprodukte der thrombin- und plasmininduzierten Blutgerinnung gemessen. Ergebnisse: Unter dem Einfluss von Amidotrizoat waren die Bildung der Prothrombinfragmente 1 und 2 sowie als Ausdruck der Thrombinaktivitaet der Thrombin-Antithrombin-III-Komplex (TAT) merklich hoeher als unter Iopromid, erreicht aber keine statistische Signifikanz (p<0,15). Die Plasmainaktivitaet, ausgedrueckt durch den Plasmin-Antiplasmin-Komplex (PAP), war nach der Angiokardiographie erhoeht. Dieser Effekt war deutlicher ausgepraegt bei Patienten, die das ionische Amidotrizoat erhalten hatten (p<0,05). Die D-dimeren Spaltprodukte und Fibrinabbauprodukte waren unter dem Einfluss von Amidotrizoat gegenueber Iopromid deutlich erhoeht (p<0,01). Die Erhoehung von Fibrinabbauprodukten und D-Dimeren sind ein direktes Mass fuer einen gesteigerten Fibrinabbau und somit indirekt auch fuer eine gesteigerte Bildung von Fibrin. Schlussfolgerung: Die Ergebnisse der hier vorgestellten Studie sind ein Hinweis dafuer, dass antikoagulatorische, die Fibrin-Polymerisierung inhibierende Effekte von ionischem Roentgenkontrastmittel, die in vitro beschrieben wurden, auf die In-vivo-Situation im haemostatischen System nicht uebertragbar sind. (orig.)

  19. Assessment of Left Ventricular Volume and Function Using Real-Time 3D Echocardiography versus Angiocardiography in Children with Tetralogy of Fallot

    OpenAIRE

    Abdel Aziz, Faten M; Abdel Dayem, Soha M; Ismail, Reem I; Hassan, Hebah; Aya M Fattouh

    2016-01-01

    Background Evaluation of left ventricular (LV) size and function is one of the important reasons for performing echocardiography. Real time three dimensional echocardiography (RT3DE) is now available for a precise non-invasive ventricular volumetry. Aim of work was to validate RT3DE as a non-invasive cardiac imaging method for measurement of LV volumes using cardiac angiography as the reference technique. Methods Prospective study on 40 consecutive patients with tetralogy of Fallot (TOF) refe...

  20. Assessment of Left Ventricular Volume and Function Using Real-Time 3D Echocardiography versus Angiocardiography in Children with Tetralogy of Fallot

    Science.gov (United States)

    Abdel Aziz, Faten M; Abdel Dayem, Soha M; Ismail, Reem I; Hassan, Hebah

    2016-01-01

    Background Evaluation of left ventricular (LV) size and function is one of the important reasons for performing echocardiography. Real time three dimensional echocardiography (RT3DE) is now available for a precise non-invasive ventricular volumetry. Aim of work was to validate RT3DE as a non-invasive cardiac imaging method for measurement of LV volumes using cardiac angiography as the reference technique. Methods Prospective study on 40 consecutive patients with tetralogy of Fallot (TOF) referred for cardiac catheterization for preoperative assessment. Biplane cineangiography, conventional 2 dimensional echocardiography (2DE) and RT3DE were performed for the patients. A control group of 18 age and sex matched children was included and 2DE and RT3DE were performed for them. Results The mean LV end diastolic volume (LVEDV) and LVEDV index (LVEDVI) measured by RT3DE of patients were lower than controls (p value = 0.004, 0.01, respectively). There was strong correlation between the mean value of the LVEDV and the LVEDVI measured by RT3DE and angiography (r = 0.97, p assessed by 2DE (50 ± 6.2%, 65 ± 4.6%, respectively, p value < 0.001) in the studied TOF cases. There was good intra- and inter-observer reliability for all measurements. Conclusion RT3DE is a noninvasive and feasible tool for measurement of LV volumes that strongly correlates with LV volumetry done by angiography in very young infants and children, and further studies needed. PMID:27358704

  1. Automatic selection of the left ventricular sampling region by nuclear angiocardiography and extraction of the ejection fraction as compared with the three-region-method by hand

    International Nuclear Information System (INIS)

    A program for automatic determination of the left ventricle contour and for automatic calculation of the ejection fraction is presented. The results are comparable to those of the tedious manual evaluation procedure. Preconditions are: A suitable statistics of counting rates and a correct projection of the left ventricle without superposition of the left atrium or the right ventricle. (WU)

  2. Determination of differences in the left ventricular ejection fraction (LVEF) by radionuclides and echocardiography pre and post treatment with anthracycline in pediatric patients with oncology diagnostic of the La Raza Medical Center

    International Nuclear Information System (INIS)

    The objective of this work was to correlate the left ventricular ejection fraction determine by radionuclide angiocardiography and echocardiography in pediatric patients under anthracycline treatment. Material and methods: 41 patients were studied with range age from 3 to 14 years, with oncology diagnostic that were treated with anthracycline. Radionuclide angiocardiography and echocardiography were performed before an after anthracycline administration to determine the changes in the Ieft ventricular ejection fraction. Results: Anthracycline treatment caused no changes in the electrocardiography, echocardiogram and radionuclide angiocardiography. Conclusions: In our study anthracycline treatment caused no changes in the electrocardiography, echocardiography and both radionuclide angiocardiography techniques, first-pass and equilibrium. A high correlation was obtaining when left ventricular ejection fraction is compared between radionuclide angiocardiography and echocardiogram. (Author)

  3. Determination of differences in the left ventricular ejection fraction (LVEF) by radionuclides and echocardiography pre and post treatment with anthracycline in pediatric patients with oncology diagnostic of the La Raza Medical Center; Determinacion de diferencias en la fraccion de eyeccion del ventriculo izquierdo (FEVI) por radionuclidos y ecocardiografia pre y post tratamiento con antraciclinas en pacientes pediatricos con diagnostico oncologico del Centro Medico La Raza

    Energy Technology Data Exchange (ETDEWEB)

    Veras R, H

    2003-07-01

    The objective of this work was to correlate the left ventricular ejection fraction determine by radionuclide angiocardiography and echocardiography in pediatric patients under anthracycline treatment. Material and methods: 41 patients were studied with range age from 3 to 14 years, with oncology diagnostic that were treated with anthracycline. Radionuclide angiocardiography and echocardiography were performed before an after anthracycline administration to determine the changes in the Ieft ventricular ejection fraction. Results: Anthracycline treatment caused no changes in the electrocardiography, echocardiogram and radionuclide angiocardiography. Conclusions: In our study anthracycline treatment caused no changes in the electrocardiography, echocardiography and both radionuclide angiocardiography techniques, first-pass and equilibrium. A high correlation was obtaining when left ventricular ejection fraction is compared between radionuclide angiocardiography and echocardiogram. (Author)

  4. Angiographic evaluation of conjoined twins

    International Nuclear Information System (INIS)

    Two sets of conjoined twins were studied by angiocardiography and cerebral angiography. Conjoined heart was demonstrated in the thoracopagus twins and surgical separation was impossible. Cerebral angiography disclosed the separate circulations in craniopagus twins and surgical separation was performed. (orig.)

  5. Measurement of right and left ventricular ejection fraction in dogs

    Energy Technology Data Exchange (ETDEWEB)

    Brynjolf, I.; Qvist, J.; Mygind, T.; Jordening, H.; Dorph, S.; Munck, O.

    1983-08-01

    Three techniques for measurement of right (RVEF) and two techniques for left (LVEF) ventricular ejection fraction were evaluated in five dogs. RVEF was measured with a first-pass radionuclide technique using erythrocytes labelled in vitro with Technetium-99m methylene disphosphonate (MDP) and compared with RVEF measured with a thermodilution technique. Thermodilution-determined RVEF was compared with RVEF values measured with cine angiocardiography. LVEF was measured with a radionuclide ECG-gated equilibrium technique and compared with cine angiocardiography. Measurements were performed before and during a continuous infusion of dopamine. There was an excellent correlation between RVEF measured with the first-pass and the thermodilution technique. LVEF measured with the ECG-gated equilibrium technique correlated well with cine angiocardiography.

  6. Fallot's tetralogy in combination with an open common atrioventricular canal

    International Nuclear Information System (INIS)

    The methods and clinics of diagnostics of Fallot tetrad (FT) combined with the opened general atrioventricular canal (AVC) of the heart are described on the basis of observation of a 6.5-year old patient and analysis of literary data. On the basis of studying clinical data, electro-, phono-, echocardiography and roentgenography, as well as heart catheterization and angiocardiography the conclusion is made that nowadays the most informative method of diagnostics of FT and AVC combination before angiocardiography is a dimer echocardiography which permits to diagnoze AVC. Angiocardiographic study proves this diagnosis and gives a precise anotomical picture of various components of this combination of heart failure

  7. Congenital heart disease

    Institute of Scientific and Technical Information of China (English)

    1992-01-01

    920654 Angiocardiography in double out-let right ventricle with emphasis on anato-mic types, diagnosis and differential dia-gnosis. LI Yiqun (李益群), et al. Dept Radiol,Cardiovasc Instit & Fuwai Hosp, CAMS, 100037.Chin J Radiol 1992; 26(6): 380-384. Based on the correlative study of angiocardic-graphy and surgical exploration in 52 cases with

  8. Cor triatriatum dextrum - an unusual variant of triatrial heart

    International Nuclear Information System (INIS)

    The present report describes a rare case of triatrial heart, cor triatriatum dextrum in a 31-year-old woman in whom the anomaly was incidentally detected by radionuclide angiocardiography. Subsequent assessment with two-dimensional echocardiography and right heart catheterization confirmed the presence of a membrane subdividing the right atrium into two distinct chambers. To the best of our knowledge, this is the only case in which this cardiac anomaly was demonstrated by radionuclide technique. (orig.)

  9. The application of angiography in conjoined twins

    International Nuclear Information System (INIS)

    Objective: To report a case of conjoined twins with peripheral angiography together with cardioangiographic technique. Methods: Left ventriculogram, right ventriculogram, descending aortogram and selected celiac arteriogram were separately performed for both babies of the conjoined twin. Results: Angiocardiography showed the anatomy of cardiac and abdominal vessels of the thoraco-omphalopagus conjoined twin clearly and confirmed by the separation operation. Conclusions: The angiographic examination is difficult but very helpful for successful operation of the conjoined twin. (authors)

  10. Assessment of ventricular function with first-pass radionuclide angiography using technetium 99m hexakis-2-methoxyisobutylisonitrile: A European multicentre study

    International Nuclear Information System (INIS)

    In the context of a multicentre study on the use of technetium 99m hexakis-2-methoxyisobutylisonitrile (99mTc-Sestamibi), we evaluated the accuracy of the ventricular function assessed at rest by means of first-pass radionuclide angiocardiography acquired during the injection of the tracer for myocardial perfursion scintigraphy. The results were compared with first-pass studies performed using reference tracers sodium pertechnetate Tc 99m or technetium 99m diethylene triamine penta-acetic acid or with gated radionuclide angiocardiography. A total of 66 patients of the 105 enrolled in the study could be evaluated. The comparison of the first-pass studies was possible in 33 subjects with regard to the left ventricular ejection fraction, yielding r=0.909 (P-6), and in 22 cases with regard to the right ventricular ejection fraction, yielding r=0.712 (P99mTc-Sestamibi and the equilibrium gated radionuclide angiocardiography was possible for the left ventricular ejection fraction in 26 cases, with r = 0.937 (P-6), and for the right ventricular ejection fraction in 15 subjects, with r=0.783 (P99mTc-Sestamibi for perfusion myocardial scintigraphy can be considered reliable and accurate, when compared with the usually employed techniques. This result confirms the feasibility of a combined evaluation of perfusion and function at rest and during stress testing, which represents one of the most interesting advantages offered by the use of 99mTc-Sestamibi. (orig.)

  11. Assessment of ventricular function with first-pass radionuclide angiography using technetium 99m hexakis-2-methoxyisobutylisonitrile: A European multicentre study

    Energy Technology Data Exchange (ETDEWEB)

    Bisi, G.; Sciagra, R. (Florence Univ. (Italy). Dipt. di Fisiopatologia Clinica); Buell, U. (Technische Hochschule Aachen (Germany, F.R.). Medizinische Fakultaet); Britton, K.E. (Saint Bartholomew' s Hospital, London (UK). Dept. of Nuclear Medicine); Eilles, C. (Luitpoldkrankenhaus, Wuerzburg (Germany, F.R.)); Eissner, D.; Hahn, K. (Mainz Univ. (Germany, F.R.). Klinikum); Hoeffken, H.; Joseph, K. (Marburg Univ. (Germany, F.R.). Klinikum); McKillop, J.H. (Royal Infirmary, Glasgow (UK). Dept. of Medicine); Larock, M.P.; Rigo, P. (Centre Hospitalier Universitaire Sart-Tilman, Tilman (Belgium). Service de Medecine Nucleaire); Mueller, S.P.; Reiners, C. (Essen Univ. (Gesamthochschule) (Germany, F.R.). Klinikum)

    1991-03-01

    In the context of a multicentre study on the use of technetium 99m hexakis-2-methoxyisobutylisonitrile ({sup 99m}Tc-Sestamibi), we evaluated the accuracy of the ventricular function assessed at rest by means of first-pass radionuclide angiocardiography acquired during the injection of the tracer for myocardial perfursion scintigraphy. The results were compared with first-pass studies performed using reference tracers sodium pertechnetate Tc 99m or technetium 99m diethylene triamine penta-acetic acid or with gated radionuclide angiocardiography. A total of 66 patients of the 105 enrolled in the study could be evaluated. The comparison of the first-pass studies was possible in 33 subjects with regard to the left ventricular ejection fraction, yielding r=0.909 (P<10{sup -6}), and in 22 cases with regard to the right ventricular ejection fraction, yielding r=0.712 (P<0.001). The comparison between the first-pass study using {sup 99m}Tc-Sestamibi and the equilibrium gated radionuclide angiocardiography was possible for the left ventricular ejection fraction in 26 cases, with r = 0.937 (P<10{sup -6}), and for the right ventricular ejection fraction in 15 subjects, with r=0.783 (P<0.001). In conclusion, the assessment of ventricular function performed by acquiring a first-pass radionuclide angiocardiograph during the injection of {sup 99m}Tc-Sestamibi for perfusion myocardial scintigraphy can be considered reliable and accurate, when compared with the usually employed techniques. This result confirms the feasibility of a combined evaluation of perfusion and function at rest and during stress testing, which represents one of the most interesting advantages offered by the use of {sup 99m}Tc-Sestamibi. (orig.).

  12. The Digitron for densitometric assessment of the ventricular ejection fraction and valvular regurgitation

    International Nuclear Information System (INIS)

    The right and left ventricular ejection fractions are important parameters in the assessment of cardiac functions. In cases of valvular insufficiency, objective determination of the degree of regurgitation is of great significance. Video-angiocardiography for dynamic measurement of contrast medium clearing out is a technique well established for years now for determining the ejection fraction and the regurgitation fraction. Digital subtraction techniques are available for detecting disturbing impacts, so that densitometric measurement of the ejection fraction and the regurgitation fraction may well become a routine diagnostic tool, provided the digital image recording system is applied with the required digital substraction software. (orig.)

  13. Congenital hepatic arteriovenous fistula with intrahepatic portosystemic shunt and aortic stenosis in a dog

    International Nuclear Information System (INIS)

    Examination of a 2-month-old male golden retriever presented to the hospital revealed malnutrition, ascites, cardiac murmur and hyperammonemia. Identification of subaortic stenosis and hepatic arteriovenous fistula was made through ultrasonography and angiocardiography. In addition, intrasurgical mesenteric portography showed an intrahepatic portosystemic shunt. The dog did not show portal hypertension and secondary multiple extrahepatic portosystemic shunts. Surgical correction was attempted after medical treatment. The hepatic artery branch which was connected to the hepatic arteriovenous fistula was separated, and completely ligated using silk ligature. However, the separation of the intrahepatic shunt blood vessel was unsuccessful and the dog died 15 hr postoperatively

  14. Value and limits of the computed tomography of the heart

    International Nuclear Information System (INIS)

    In cardiac diagnosis we can observe an increasing replacement of the conventional invasive examination methods by less invasive or non invasive procedures. Non invasive examination methods are sufficient in the diagnostic work-up of ventricular function in coronary heart disease and cardiomyopathie, cardiac tumours and thrombi, calcifications, assessment of the bypass perfusion, pericardial disease, positional anomalies of the heart and the morphological changes caused by congenital cardiovascular defects. Invasive angiocardiography remains essential in the diagnosis of coronary artery stenoses, abnormal bypass perfusion, septal defects and in congenital cardiovascular defects in combination with intracardiac measurements of pressure and oxygenation. (orig.)

  15. A deconvolution program for processing radiotracer dilution curves

    International Nuclear Information System (INIS)

    The authors present a computer program for deconvolution of noisy signals. The unknown signal is modelled as a stochastic process and the solution is given by the 'maximum a posteriori estimator'. This is computed by two algorithms: the first uses the Kalman filter; the second the conjugate gradient technique which permits introduction of a positivity constraint. The program has proved to give accurate results in simulation studies. It has been applied to the deconvolution analysis of radionuclide angiocardiography time-activity curves. This improves the reliability of the results in left-to-right cardiac shunt quantitation. (Auth.)

  16. Diagnosis of common congenital heart anomalies in the dog using survey and nonselective contrast radiography

    International Nuclear Information System (INIS)

    The most common canine congenital heart anomalies include patient ductus arteriosus, ventricular septal defects, tetralogy of Fallot, pulmonic stenosis, and aortic stenosis. Survey radiography and nonselective (venous) angiography can allow the practicing veterinarian to confirm the diagnosis in many of these patients. Typical radiographic findings using these diagnostic procedures are reviewed. Nonselective angiocardiography is a relatively easy, rapid, and noninvasive procedure which can be performed using conventional equipment. The major disadvantage of this special procedure is that the superimposition of opacified structures can make the identification of some left-to-right shunts difficult. Dilution of contrast medium can occur if a rapid bolus injection is not made

  17. Radiological diagnosis of total anomalous pulmonary venous connection with right superior vena cava

    International Nuclear Information System (INIS)

    Objective: To evaluate radiographic diagnosis in total anomalous pulmonary venous connection with right superior vena cava (RSVC-TAPVC) and analyze the variant of its pulmonary venous connection and the influence on surgical operation. Methods: In 11 patients who were diagnosed by angiocardiography and confirmed by surgical operation, all chest radiographs were studied retrospectively and compared with their angiocardiography and surgical results. The variant of pulmonary venous connection was analyzed and the influence on surgical operation was also discussed. Results: 6 patients showed 'right hemi-snowman sign' in posteroanterior view and 3 showed a pre-tracheal density on the lateral view or other sign caused by drainage vein. 6 of 9 angio-cardiographs showed pulmonary or drainage venous stenosis. There were 2, 4 and 3 cases respectively whose right pulmonary veins connected with common pulmonary or drainage veins in one, two, and three branches. 2 of 3 died cases were caused by mistaken ligation of right superior pulmonary vein during the operation. Conclusion: About 82% cases of the RSVC-TAPVC can be diagnosed by chest radiograph because of the 'right hemi-snowmen sign' and other supplementary signs. In about 78% cases, the right pulmonary veins join right drainage (or connecting) vein in two or more branches at separate levels and this variant has surgical implications

  18. Pre-operative evaluation with MR in tetralogy of Fallot and pulmonary atresia with ventricular septal defect

    International Nuclear Information System (INIS)

    To assess whether MR imaging could replace angiography in pre-operative evaluation of patients with tetralogy of Fallot and pulmonary atresia with ventricular septal defect (VSD), especially since the surgical correction was done earlier than was previously the rule. Fourteen patients with tetralogy of Fallot (n=10) or pulmonary atresia with VSD (n=4), mean age 7.5±4.4 months, were evaluated with angiocardiography and MR before definitive surgical correction. There was good diagnostic agreement between the two modalities when evaluating right ventricular outflow obstruction; 86% for valvular and 93% for supra valvular stenosis, but the agreement was somewhat lower for the sub valvular obstruction (57%). Surgery findings, however, were in favour of MR in 5 patients concerning the sub valvular right ventricular outflow tract obstruction. MR images identified all stenoses in the right and left pulmonary arteries, but overlooked one stenosis in the main pulmonary artery. MR could evaluate patency in all palliative shunts. Even in this young age group, MR imaging offers a good alternative to angiocardiography for the pre-operative evaluation of the right ventricular outflow tract, the main pulmonary artery and the proximal right and left pulmonary arteries, before definitive surgical correction of tetralogy of Fallot and pulmonary atresia with VSD

  19. Cardiovascular nuclear medicine in infancy and childhood

    International Nuclear Information System (INIS)

    Radionuclide angiocardiography and lung scanning in the diagnosis of congenital heart disease in infants and children are introduced and discussed. Recently developed radionuclide angiocardiography is a safe and useful method in the detection and quantification of intracardiac shunts, together with for the measurement of transit times, left ventricular ejection fraction and cardiac output. Lung scanning is useful in the evaluation of pulmonary blood flow distribution in the congenital heart disease such as ventricular septal defect (VSD), tetralogy of Fallot (TOF), etc. To decide the limitation of operative indication for VSD with severe pulmonary hypertension, the ratio of pulmonary blood flow distribution in upper to lower lung filed above 1.2, the right to left shunt ratio above 0.25, and deranged blood flow distribution on bilateral lungs are useful as the criteria. In the follow up study after intracardiac repair of TOF, lung scanning reflects the residua and sequalae such as pulmonary stenosis, pulmonary insufficiency, pulmonary hypertension, peripheral pulmonary stenosis and anomalous dilatation of the right ventricular outflow tract. (author)

  20. Pre-operative evaluation with MR in tetralogy of Fallot and pulmonary atresia with ventricular septal defect

    Energy Technology Data Exchange (ETDEWEB)

    Holmqvist, C.; Hochbergs, P. [Univ. Hospital, Lund (Sweden). Dept of Diagnostic Radiology; Bjoerkhem, G. [Univ. Hospital, Lund (Sweden). Dept of Paediatrics; Brockstedt, S.; Laurin, S. [Univ. Hospital, Lund (Sweden). Dept of Diagnostic Radiology

    2000-01-01

    To assess whether MR imaging could replace angiography in pre-operative evaluation of patients with tetralogy of Fallot and pulmonary atresia with ventricular septal defect (VSD), especially since the surgical correction was done earlier than was previously the rule. Fourteen patients with tetralogy of Fallot (n=10) or pulmonary atresia with VSD (n=4), mean age 7.5{+-}4.4 months, were evaluated with angiocardiography and MR before definitive surgical correction. There was good diagnostic agreement between the two modalities when evaluating right ventricular outflow obstruction; 86% for valvular and 93% for supra valvular stenosis, but the agreement was somewhat lower for the sub valvular obstruction (57%). Surgery findings, however, were in favour of MR in 5 patients concerning the sub valvular right ventricular outflow tract obstruction. MR images identified all stenoses in the right and left pulmonary arteries, but overlooked one stenosis in the main pulmonary artery. MR could evaluate patency in all palliative shunts. Even in this young age group, MR imaging offers a good alternative to angiocardiography for the pre-operative evaluation of the right ventricular outflow tract, the main pulmonary artery and the proximal right and left pulmonary arteries, before definitive surgical correction of tetralogy of Fallot and pulmonary atresia with VSD.

  1. The effect of nitroglycerin on response to tracheal intubation. Assessment by radionuclide angiography

    International Nuclear Information System (INIS)

    The effect of intravenous (IV) nitroglycerin (NTG) on perioperative myocardial ischemia as detected by single pass radionuclide angiocardiography was studied in 20 patients scheduled for elective coronary artery bypass grafting (CABG). Ten patients, selected at random, received IV NTG 1 microgram.kg-1.min-1 (NTG group) and 10 others, IV saline (control group). Anesthetic induction consisted of midazolam 0.2 mg.kg-1, vecuronium 0.1 mg.kg-1, and 50% N2O in O2. ECG leads I, II, and V5 were monitored for ST segment changes. Single pass radionuclide angiocardiography (RNA) was performed at 5 times: prior to induction, prior to tracheal intubation, and at 1, 3.5, and 6 min following intubation. The presence of new regional wall motion abnormalities (RWMA) was determined from each RNA study as compared with the preinduction measurement. Apart from one patient in the control group who developed a new ''v'' wave after intubation, there was no evidence of ischemia by pulmonary capillary wedge pressure. No ECG evidence of ischemia was detected in any patient. Despite this, new regional wall motion abnormalities were observed in 3 patients in the control group and 1 patient in the NTG group. Blood pressure and heart rate responses of patients with new RWMA were not significantly different from other patients. The low incidence of ischemia in this population precludes a definitive statement regarding the efficacy of IV NTG, but the lower incidence of RWMA in the NTG group suggests a protective effect

  2. Assessment of regional left ventricular function by Dual Source Computed Tomography: Interobserver variability and validation to laevocardiography

    Energy Technology Data Exchange (ETDEWEB)

    Pflederer, T. [Department of Internal Medicine 2 (Cardiology), University of Erlangen (Germany)], E-mail: tobiaspflederer@web.de; Ho, K.T. [Department of Cardiology, Tan Tock Seng Hospital (Singapore)], E-mail: contact@ttsh.com.sg; Anger, T. [Department of Internal Medicine 2 (Cardiology), University of Erlangen (Germany)], E-mail: thomas.anger@uk-erlangen.de; Kraehner, R. [Department of Internal Medicine 2 (Cardiology), University of Erlangen (Germany)], E-mail: robert.kraehner@uk-erlangen.de; Ropers, D. [Department of Internal Medicine 2 (Cardiology), University of Erlangen (Germany)], E-mail: dieter.ropers@uk-erlangen.de; Muschiol, G. [Department of Internal Medicine 2 (Cardiology), University of Erlangen (Germany)], E-mail: gerd.muschiol@uk-erlangen.de; Renz, A. [Department of Internal Medicine 2 (Cardiology), University of Erlangen (Germany)], E-mail: alexandra.renz@uk-erlangen.de; Daniel, W.G. [Department of Internal Medicine 2 (Cardiology), University of Erlangen (Germany)], E-mail: werner.daniel@uk-erlangen.de; Achenbach, S. [Department of Internal Medicine 2 (Cardiology), University of Erlangen (Germany)], E-mail: stephan.achenbach@uk-erlangen.de

    2009-10-15

    Objective: Assessment of left ventricular function is possible in contrast-enhanced cardiac CT data sets. However, rapid ventricular motion especially in systole can lead to artifacts. Dual Source Computed Tomography (DSCT) has high temporal resolution which effectively limits motion artifact. We therefore assessed the accuracy of DSCT to detect regional left ventricular wall motion abnormalities in comparison to invasive cine angiocardiography. Methods: We analyzed DSCT data sets of 50 patients (39 male, 11 female, mean age: 61 {+-} 10 years) which were acquired after intravenous injection of 55-70 mL contrast agent (rotation time: 330 ms, collimation: 2 mm x 64 mm x 0.6 mm, 120 kV, 380 mAs, ECG-correlated tube current modulation). 10 data sets consisting of transaxial slices with a slice thickness of 1.5 mm, an increment of 1.0 mm and a matrix of 256 x 256 pixels were reconstructed at 10 time instants during the cardiac cycle (0-90% in 10% increments). The data sets were analyzed visually by two independent readers, using standard left ventricular planes, concerning regional wall motion abnormalities. DSCT was verified in a blinded fashion against cine ventriculography performed during cardiac catheterization (RAO and LAO projection), using a 7-segment model. Analysis was performed on a per-patient (presence of at least one hypo-, a- or dyskinetic segment) and on a per-segment basis. Results: Concerning the presence of a wall motion abnormality, the two observers agreed in 340/350 segments (97%) and 48/50 patients (96%). In invasive cine angiocardiography, 22 of 50 patients displayed at least one segment with abnormal contraction. To detect these patients, DSCT showed a sensitivity of 95% (21/22), specificity of 96% (27/28), positive predictive value of 95% and negative predictive value of 96%. Out of a total of 350 left ventricular segments, 66 segments had abnormal contraction in cine angiocardiography (34 hypokinetic, 26 akinetic, 6 dyskinetic). For detection

  3. Comparison of high temporal resolution left ventricular volume curves before and after mitral valve replacement

    International Nuclear Information System (INIS)

    A patient with severe mitral insufficiency was studied preoperatively by conventional cardiac catheterization, including left ventricular contrast angiography, and also by ECG-gated scintigraphic angiocardiography. Following mitral valve replacement the patient was again studied both by cardiac catheterization and by the scintigraphic procedure. A comparison of preoperative left ventricular volume curves derived from a frame-by-frame analysis of the contrast angiogram, and from the scintigraphic procedure, showed good agreement. A major feature of both preoperative volume curves was a large, early diastolic filling rate. The postoperative scintigraphic volume curve exhibited a marked reduction in early filling rate and a much reduced end-diastolic volume. This study suggests that the scintigraphic procedure is capable of closely following diastolic and systolic changes in left ventricular volume

  4. X-ray examination in diagnosis of hepatic segment deficiency of inferior cava

    Energy Technology Data Exchange (ETDEWEB)

    Kiseleva, I.P.; Podzolkov, V.P.; Ivanitskij, A.V.; Mal' sagov, G.U. (Akademiya Meditsinskikh Nauk SSSR, Moscow. Inst. Serdechno-Sosudistoj Khirurgii; Tsentral' nyj Inst. Usovershenstvovaniya Vrachej, Moscow (USSR))

    Data on clinical and X-ray examination of 29 patients aged 2 weeks to 66 years with vena cava inferior hepatic segment deficiency are presented. The blood outflow from the lower part of the body was effected through the azygos vein in 17 patients, and through the hemiazygos one in 12 patients. The data obtained were in all cases correlated with the results of intracardiac research methods (the right and left heart cavities catherization and angiocardiography), with intraoperative and autopsy findings. An anomaly was found to prevail in patients (89.6%) with different types of abnormal heart position in the thoracic cavity. Along with examination of the cardiovascular system, the abdominal organs study was carried out: standard roentgenoscopy and radiography, both aiming to detect the liver position, gastrointestinal tract examination, and cholecystography.

  5. Iohexol for contrast enhancement of bowel in pediatric abdominal CT

    International Nuclear Information System (INIS)

    Abdominal CT scans from 160 examinations performed on pediatric patients using iohexol 2 percent as contrast medium for bowel enhancement were evaluated retrospectively. When diluted with a beverage of the child's choice, iohexol has a neutral taste and cannot be detected, and 139 out of 142 patients drank the full amount of dilute contrast offered to them. The enhancement of bowel in the area of interest was graded as good (58%), reasonable (23%), or poor (19%). The contrast medium was prepared from leftovers from our angiocardiography studies. We conclude that the use of water-soluble contrast medium in a low concentration is a safe and cost-effective way of facilitating ingesion of sufficient amounts of the medium in oncologic pediatric patients undergoing cytotoxic and/or radiation treatment. (orig.)

  6. X-ray examination in diagnosis of hepatic segment deficiency of inferior cava

    International Nuclear Information System (INIS)

    Data on clinical and X-ray examination of 29 patients aged 2 weeks to 66 years with vena cava inferior hepatic segment deficiency are presented. The blood outflow from the lower part of the body was effected through the azygos vein in 17 patients, and through the hemiazygos one in 12 patients. The data obtained were in all cases correlated with the results of intracardiac research methods (the right and left heart cavities catherization and angiocardiography), with intraoperative and autopsy findings. An anomaly was found to prevail in patients (89.6%) with different types of abnormal heart position in the thoracic cavity. Along with examination of the cardiovascular system, the abdominal organs study was carried out: standard roentgenoscopy and radiography, both aiming to detect the liver position, gastrointestinal tract examination, and cholecystography

  7. Noninvasive measurement of pulmonary blood volume

    International Nuclear Information System (INIS)

    In noninvasive estimation of pulmonary blood volume by radionuclide-angiocardiography, a formula was derived from experiments with heart-lung model, and in vivo experiments PBV = CO x PPT x 0.77. The pulmonary blood volume estimated clinically by this formula was in good agreement with the results obtained invasively before. The compliance (δV/δP) of the pulmonary ''venous'' system was calculated by simultaneous measurement of pressure changes in lung field on leg elevation and changes in pulmonary arterial wedge pressure with Swan-Ganz catheter. The compliances which were calculated in 35 cases of heart diseases by this method were in a considerably good agreement with those which were assessed by analysis of a pulmonary arterial wedge pressure tracing. (Ueda, J.)

  8. Cardiac contractility, central haemodynamics and blood pressure regulation during semistarvation

    DEFF Research Database (Denmark)

    Stokholm, K H; Breum, L; Astrup, A

    1991-01-01

    pressure (BP) declined. The fall in BP was caused by the reduction in cardiac output as the total peripheral resistance was unchanged. Finally, the decline in total blood volume was not significant. These findings together with a reduction in heart rate indicated that a reduced sympathetic tone via......Eight obese patients were studied before and after 2 weeks of treatment by a very-low-calorie diet (VLCD). Cardiac output and central blood volume (pulmonary blood volume and left atrial volume) were determined by indicator dilution (125I-albumin) and radionuclide angiocardiography (first pass and...... equilibrium technique by [99Tcm]red blood cells). Cardiac output decreased concomitantly with the reduction in oxygen uptake as the calculated systemic arteriovenous difference of oxygen was unaltered. There were no significant decreases in left ventricular contractility indices, i.e. the ejection fraction...

  9. Computer processing of dynamic scintigraphic studies

    International Nuclear Information System (INIS)

    The methods are discussed of the computer processing of dynamic scintigraphic studies which were developed, studied or implemented by the authors within research task no. 30-02-03 in nuclear medicine within the five year plan 1981 to 85. This was mainly the method of computer processing radionuclide angiography, phase radioventriculography, regional lung ventilation, dynamic sequential scintigraphy of kidneys and radionuclide uroflowmetry. The problems are discussed of the automatic definition of fields of interest, the methodology of absolute volumes of the heart chamber in radionuclide cardiology, the design and uses are described of the multipurpose dynamic phantom of heart activity for radionuclide angiocardiography and ventriculography developed within the said research task. All methods are documented with many figures showing typical clinical (normal and pathological) and phantom measurements. (V.U.)

  10. Evidence for a possible calcium flux dependent cardiomyopathy in hyperthyroidism

    International Nuclear Information System (INIS)

    This study was designed to test the hypothesis that the impaired functional cardiac reserve to exercise in hyperthyroidism is related to alterations in the regulation of calcium transport. In 2l hyperthyroid patients, the left ventricular ejection fraction (LVEF) was measured using equilibrium gated radionuclide angiocardiography at rest and during supine dynamic exercise. After a recovery period, the patients performed a second exercise study after random administration of Verapamil, a calcium entry blocker (11 pts), or propanolol, a beta adrenergic antagonist (10 pts) for comparison. The results showed i) normal resting LVEF with no significant change during exercise before any medication, ii) resting LVEF significantly decreased after Propanolol, and no significantly changed after Verapamil, iii) during exercise, significant increase of LVEF after Verapamil, and no significant change after Propanolol. These results are consistent with previous studies showing that abnormal change in LVEF during exercise in hyperthyroidism seems independent of beta adrenergic activation, and suggest a reversible functional cardiomyopathy dependent of calcium transporting systems

  11. Do radiologists control angiographic and interventional procedures

    International Nuclear Information System (INIS)

    Academic institutions nationwide were surveyed to determine the degree to which radiologists control 13 angiographic or interventional procedures that are potential turf battles. The data reveal that academic radiologists retain virtually complete control of peripheral angioplasty, renal angioplasty, percutaneous biliary drainage, and CT- or US-guided abscess drainage. They largely dominate percutaneous nephrostomies, percutaneous ureteral stent placements, and pulmonary angiography. They have somewhat lesser but still important roles in percutaneous gastrostomy and inferior vena cava filter placement. Radiologists control kidney stone lithotripsy in only 7% of institutions but have varying degrees of involvement in another 57%. The performance of coronary angiography, pediatric angiocardiography, and coronary angioplasty is almost totally controlled by cardiologists, although radiologists maintain a significant interpretive role

  12. Comparison between scintiscanning and pulmonary angiography in the diagnosis of pulmonary embolism

    International Nuclear Information System (INIS)

    In the diagnosis of pulmonary embolism, radio-isotope scanning is specific when it reveals complete absence of focal, lobar or segmental perfusion. Diffuse reductions in perfusion cannot be considered significant except in patients with healthy heart and lungs. Radio-isotope scanning shows up well peripheral emboli. Angiography provides definite evidence when it shows up intravascular lacunae or definite vascular obstructions, the diagnosis is probable when localised hypovascularisation or asymmetric vascularisation are found. Angiocardiography and pulmonary scintiscanning are neither contrary nor comparable. Radio-isotope scanning is simpler and less dangerous perhaps and may always be carried out. When it is normal, it eliminates definitely the necessity for angiography the results of which are still morphological

  13. The role of magnetic resonance tomography in the diagnosis of congenital cardiovascular disorders in children and adolescents

    International Nuclear Information System (INIS)

    In the presence of congenital cardiovascular diseases magnetic resonance tomography may be used for children of all age groups as a method providing valuable additional clues, if the information obtained by the usual non-invasive techniques is found wanting and the degree of the disease does not warrant angiocardiography. The current uses of mganetic resonance tomography are largely restricted to the major vessels, septal anomalies that are difficult to ascertain and complex lesions associated with organ displacement. Information even superior to that of angiography may be provided by magnetic resonance tomography in carefully selected cases where probing of certain cardiac or vascular sections is impossible or the disease more widely spread to include the bronchi and pulmonary parenchyma. (orig.)

  14. Instrumentation and organisation in cardiovascular nuclear medicine

    International Nuclear Information System (INIS)

    Nuclear techniques, although generally accepted in medicine, require efficient instrumentation and close cooperation between the expert in nuclear medicine and the cardiologist. The methods most frequently applied are 201Tl scintiscanning, radionuclide angiocardiography and radionuclide ventriculography. Combined application of the latter two is particularly efficient. Tl scintiscanning is most frequently applied to determine myocardial vitality, the first-pass technique is used for morphological and the steady-state technique for functional examinations. Functional examinations of the coronary arteries are carried out directly by myocardial scintiscanning while radionuclide ventriculography yields information on the heamodynamic effect of stenosis of the coronary arteries via measurement of the ventricular function. In consequence, there is a wide range of indications in which myocardial scintiscanning and radionuclide ventriculography are equally applicable; myocardial scintiscanning has the advantage of simplicity while radionuclide ventriculography yields important supplementary information on the ventricular function. (orig.)

  15. Positron emission tomography of the heart

    International Nuclear Information System (INIS)

    Positron emission computed tomography (PCT) represents an important new tool for the noninvasive evaluation and, more importantly, quantification of myocardial performance. Most currently available techniques permit assessment of only one aspect of cardiac function, i.e., myocardial perfusion by gamma scintillation camera imaging with Thallium-201 or left ventricular function by echocardiography or radionuclide angiocardiography. With PCT it may become possible to study all three major segments of myocardial performance, i.e., regional blood flow, mechanical function and, most importantly, myocardial metabolism. Each of these segments can either be evaluated separately or in combination. This report briefly describes the principles and technological advantages of the imaging device, reviews currently available radioactive tracers and how they can be employed for the assessment of flow, function and metabolism; and, lastly, discusses possible applications of PCT for the study of cardiac physiology or its potential role in the diagnosis of cardiac disease

  16. Positron emission tomography of the heart

    Energy Technology Data Exchange (ETDEWEB)

    Schelbert, H.R.; Phelps, M.E.; Kuhl, D.E.

    1979-01-01

    Positron emission computed tomography (PCT) represents an important new tool for the noninvasive evaluation and, more importantly, quantification of myocardial performance. Most currently available techniques permit assessment of only one aspect of cardiac function, i.e., myocardial perfusion by gamma scintillation camera imaging with Thallium-201 or left ventricular function by echocardiography or radionuclide angiocardiography. With PCT it may become possible to study all three major segments of myocardial performance, i.e., regional blood flow, mechanical function and, most importantly, myocardial metabolism. Each of these segments can either be evaluated separately or in combination. This report briefly describes the principles and technological advantages of the imaging device, reviews currently available radioactive tracers and how they can be employed for the assessment of flow, function and metabolism; and, lastly, discusses possible applications of PCT for the study of cardiac physiology or its potential role in the diagnosis of cardiac disease.

  17. Non-invasive evaluation of regional function of the left ventricle

    International Nuclear Information System (INIS)

    Assessment of regional left ventricular function with first pass angiocardiography in the RAO view almost entirely depends on high image statistics, accurate border definition and background subtraction, as well as an analysis of so called functional images which regionally measure and illustrate functional change during heart action. During first bolus transit the multicrystal camera gives an average of 300,000 cts/sec allowing precise border definition because of steepness of count changes at the LV-border. A varying background adjacent to each border point and also over the LV is subtracted. Measurements of segmental hemiaxis shortening and of zonal ejection fractions in the three zones supplied by the major coronary arteries have been performed. Clinical applications comprise examinations at rest, peak exercise, after nitroglycerin administration and after bypass graft surgery. Wall motion measured by means of hemiaxis shortening (210 segments) showed good correlation with angiocardiography in 91% of segments with normokinesis, in 90% asynergic and 88% of hypokinetic segments. Functional images corrected false negativ and false positiv wall motion measurements. In patients after myocardial infarction, there was (after NTG-administration) a significant increase in hemiaxis shortening in asynergic segment, but not in dyskinesias. Exercise studies in patients with wall motion disorders showed a significantly higher increase in global ejection fraction in patients with resting EF-values and 58% than above that value. Zonal ejection fractions after bypass surgery showed an average increase of 6.4 points if complete vascularization was performed, but no zonal increase or decrease when vascularization was incomplete or the zone included a previous myocardial infarction. (orig.)

  18. Cyanotic congenital heart disease

    Energy Technology Data Exchange (ETDEWEB)

    Yeon, Kyung Mo; Yoo, Shi Joon; Han, Man Chung; Hong, Chang Yee; Lee, Yung Kyoon [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    1979-12-15

    Authors analyzed 265 cases of cyanotic congenital heart disease in which cardiac catheterization and angiocardiography were done at the Department of Radiology, Seoul National University Hospital between April 1973 and August 1979. The results are as follows; 1. Among 265 cases, 178 patients were male and 87 patients were female. 240 patients were below the age of 20 and none was over 35 year. 2. The incidence of individual lesions are as follows: tetralogy of Fallot-176; double outlet right ventricle-20; pentalogy-12; trilogy-11; corrected transposition of great arteries-10; complete transposition of great arteries-8; pulmonary atresia-7; single ventricle-6; Ebstein's anomaly-5; total anomalous pulmonary venous return-4; tricuspid atresia-3; double outlet left ventricle-1; truncus arteriosus-1; hypoplastic left ventricle-1. 3. Fallot's teralogy, pentalogy and trilogy were characteristic in their simple chest and angiocardiographic manifestations, but in a few cases of tetralogy and pentalogy it was difficult to differentiate them from double outlet right ventricle or pulmonary atresia. 4. In double outlet right ventricle and transposition of great arteries which are the pathologic spectrum resulting from abnormal conal growth, differential points were ventricular and great arterial loop patterns and their connections but it was very difficult to differentiate them from each other by single injection into one ventricle alone. 5. Ebstein's anomaly and total anomalous pulmonary venous return were so characteristic in angiocardiography was done ventriculography alone. 6. In 7 cases with double outlet right ventricle and transposition of great arteries, selective biventriculography was done and more accurate diagnosis could be made, which was quite difficult with one ventriculography alone. In 31 cases, cineangiocardiography was done and it gave more accurate information about the type and degree of pulmonary stenosis and overriding of aorta, the origin

  19. Cyanotic congenital heart disease

    International Nuclear Information System (INIS)

    Authors analyzed 265 cases of cyanotic congenital heart disease in which cardiac catheterization and angiocardiography were done at the Department of Radiology, Seoul National University Hospital between April 1973 and August 1979. The results are as follows; 1. Among 265 cases, 178 patients were male and 87 patients were female. 240 patients were below the age of 20 and none was over 35 year. 2. The incidence of individual lesions are as follows: tetralogy of Fallot-176; double outlet right ventricle-20; pentalogy-12; trilogy-11; corrected transposition of great arteries-10; complete transposition of great arteries-8; pulmonary atresia-7; single ventricle-6; Ebstein's anomaly-5; total anomalous pulmonary venous return-4; tricuspid atresia-3; double outlet left ventricle-1; truncus arteriosus-1; hypoplastic left ventricle-1. 3. Fallot's teralogy, pentalogy and trilogy were characteristic in their simple chest and angiocardiographic manifestations, but in a few cases of tetralogy and pentalogy it was difficult to differentiate them from double outlet right ventricle or pulmonary atresia. 4. In double outlet right ventricle and transposition of great arteries which are the pathologic spectrum resulting from abnormal conal growth, differential points were ventricular and great arterial loop patterns and their connections but it was very difficult to differentiate them from each other by single injection into one ventricle alone. 5. Ebstein's anomaly and total anomalous pulmonary venous return were so characteristic in angiocardiography was done ventriculography alone. 6. In 7 cases with double outlet right ventricle and transposition of great arteries, selective biventriculography was done and more accurate diagnosis could be made, which was quite difficult with one ventriculography alone. In 31 cases, cineangiocardiography was done and it gave more accurate information about the type and degree of pulmonary stenosis and overriding of aorta, the origin of great

  20. Quantitative estimation of compliance of human systemic veins by occlusion plethysmography with radionuclide. Methodology and the effect of nitroglycerin

    Energy Technology Data Exchange (ETDEWEB)

    Takatsu, Hisato; Gotoh, Kohshi; Suzuki, Takahiko; Ohsumi, Yukio; Yagi, Yasuo; Tsukamoto, Tatsuo; Terashima, Yasushi; Nagashima, Kenshi; Hirakawa, Senri (Gifu Univ. (Japan). Faculty of Medicine)

    1989-03-01

    Volume-pressure relationship and compliance of human systemic veins were estimated quantitatively and noninvasively using radionuclide. The effect of nitroglycerin (NTG) on these parameters was examined. Plethysmography with radionuclide (RN) was performed using the occlusion method on the forearm in 56 patients with various cardiac diseases after RN angiocardiography with /sup 99m/Tc-RBC. The RN counts-venous pressure curve was constructed from the changes in radioactivity from region of interest on the forearm that were considered to reflect the changes in the blood volume of the forearm, and the changes in the pressure of the forearm vein (fv) due to venous occlusion. The specific compliance of the forearm veins (Csp.fv; (1/V)center dot({Delta}V/{Delta}P)) was obtained graphically from this curve at each patient's venous pressure (Pv). Csp.fv was 0.044 mmHg/sup -1/ in class I, 0.033 mmHg/sup -1/ in class II, and 0.019 mmHg/sup -1/ in class III, of the previous NYHA classification of work tolerance. The systemic venous blood volume (Vsv) was determined by subtracting the central blood volume, measured by RN-angiocardiography, from total blood volume, measured by the indicator dilution method utilizing /sup 131/I-human serum albumin. Systemic venous compliance (Csv) was calculated from Csv=Csp.fvcenter dotVsv. The Csv was 127.2 ml-mmHg/sup -1/ in class I, 101.1ml-mmHg/sup -1/ in class II and 62.2 ml-mmHg/sup -1/ in class III. There were significant differences in Csv among the three classes. The class I Csv value was calculated to be 127.2 ml-mmHg/sup -1/ and the Csv/body weight was calculated to be 2.3 ml-mmHg/sup -1/kg/sup -1/ of body weight. The administration of NTG increased Csv significantly in all cases.

  1. Quantitative estimation of compliance of human systemic veins by occlusion plethysmography with radionuclide

    International Nuclear Information System (INIS)

    Volume-pressure relationship and compliance of human systemic veins were estimated quantitatively and noninvasively using radionuclide. The effect of nitroglycerin (NTG) on these parameters was examined. Plethysmography with radionuclide (RN) was performed using the occlusion method on the forearm in 56 patients with various cardiac diseases after RN angiocardiography with 99mTc-RBC. The RN counts-venous pressure curve was constructed from (1) the changes in radioactivity from region of interest on the forearm that were considered to reflect the changes in the blood volume of the forearm, and (2) the changes in the pressure of the forearm vein (fv) due to venous occlusion. The specific compliance of the forearm veins (Csp.fv; (1/V)·(ΔV/ΔP)) was obtained graphically from this curve at each patient's venous pressure (Pv). Csp.fv was 0.044±0.012 mmHg-1 in class I (mean±SD; n=13), 0.033±0.007 mmHg-1 in class II (n=30), and 0.019±0.007 mmHg-1 in class III (n=13), of the previous NYHA classification of work tolerance. There were significant differences in Csp.fv among the three classes. The systemic venous blood volume (Vsv) was determined by subtracting the central blood volume, measured by RN-angiocardiography, from total blood volume, measured by the indicator dilution method utilizing 131I-human serum albumin. Systemic venous compliance (Csv) was calculated from Csv=Csp.fv·Vsv. The Csv was 127.2±24.8 ml·mmHg-1 (mean±SD) in class I, 101.1±24.1 ml·mmHg-1 in class II and 62.2±28.1 ml·mmHg-1 in class III. There were significant differences in Csv among the three classes. The class I Csv value was calculated to be 127.2±24.8 ml·mmHg-1 and the Csv/body weight was calculated to be 2.3±0.7 ml·mmHg-1·kg-1 of body weight. The administration of NTG increased Csv significantly in all cases. (J.P.N.)

  2. Attention for pediatric interventional radiology

    International Nuclear Information System (INIS)

    Radiological interventions possess wide utilization in the diagnosis and treatment for pediatric patients. Pediatric interventional radiology is an important branch of interventional radiology and also an important branch of pediatric radiology. Pediatric interventional radiology has grown substantially over the last 30 years, radiologists closely cooperation with surgeons and other physicians providing a new horizon in the management of pediatric diseases in western countries. It includes pediatric cardiac interventional radiology, pediatric neuro-interventional radiology, pediatric vascular interventional radiology, pediatric nonvascular interventional radiology, pediatric tumor interventional radiology and others. In the United States, every children hospital which owns two hundred beds has to have special trained interventional radiologists in radiologic department installing with advanced digital subtraction angiographic equipment. Interventional therapeutic procedures and diagnostic angiography have been proceeding more and more for the congenital and acquired diseases of children. The promising results give use uprising and interventional therapy as an alternative or a replacement or supplement to surgical operation. Pediatric interventional radiology is rather underdeveloped in China with a few special pediatric interventional radiologist, lack of digital subtraction angiography equipment. Pediatric radiologists have no enough field for interventional procedures such as pediatric neuro-interventional radiology and pediatric vascular interventional radiology. In the contrary adult interventional radiologists do have better interventional jobs in China and Pediatric cardiologists also share the same trend. They perform angiocardiography for congenital heart diseases and treat congenital heart disease with interventional procedures including balloon dilation of valves and vessels, coil embolization of collaterals, patent ducts and other arterial fistulae

  3. Arrhythmogenic right ventricular dysplasia: MR features

    International Nuclear Information System (INIS)

    Arrhythmogenic right ventricular dysplasia (ARVD) is a heart disease characterized by a total or partial fat replacement of the myocardium. A total of 30 patients were studied with a suspected diagnosis of ARVD. Clinical criteria used for evaluation of ARVD were: (a) ventricular origin arrhythmias with a left bundle branch block configuration, (b) T-wave inversion in the anterior precordial leads, (c) ventricular kinetic alterations observed using echocardiography and angiography and (d) cardiac failure when there are no pathologies attributable to other heart diseases. All patients had serial EKG and echocardiography tests. One third of patients underwent angiocardiography; 7 of 30 had Holter; 7 of 30 had exercise test just to evaluate the effectiveness of the anti-arrhythmic therapy. All patients underwent MRI examination. The following MRI criteria were used: (a) high-intensity areas indicating the fatty substitution of the myocardium, (b) ectasia of the right ventricular outflow tract, (c) dyskinetic bulges, (d) dilation of the right ventricle and (e) enlargement of the right atrium. The diagnosis of ARVD was classified as highly probable for patients manifesting at least three positive criteria, probable with two positive criteria, dubious with one and negative in the absence of all criteria. Highly probable diagnosis of ARVD was made in 8 patients, probable in 4, dubious in 7 and negative in 11. The MRI technique is very effective in the assessment of ARVD. The MRI criteria may be helpful in the diagnosis of this condition. (orig.). With 6 figs., 1 tab

  4. Dilated coronary sinus in a dog with persistent left cranial vena cava

    International Nuclear Information System (INIS)

    This paper describes the electrocardiographic, echocardiographic (two-dimensional, M-mode, contrast and Doppler) and non-selective angiocardiographic features in a 3 year old female Beagle with dilated coronary sinus due to persistent left cranial vena cava. Negative P waves in leads III and aVR and a positive P wave in lead aVL were seen, Echocardiographically, a hipoechoic circular structure was seen between the left atrium and the pericardium in the area where the coronary sinus islocated, A velocity pattern with two peaks was obtained, one systolicwith velocity = 0.44 +/- 0.05 m/sec and the other diastolic with velocity = 0.27 +/- 0.01 m/sec, By M-mode echocardiography, at level of the aorta and the left atrium, a linear structure was identified betweenthe left atrium and the pericardium; this structure was characterizedby phasic movements of the anterior wall during the cardiac cycle, Following a left cephalic vein injection of saline, bubbles were seen within the coronary sinus; when saline was injected into the right cephalic vein, bubbles were also seen within the coronary sinus and right atrium and ventricle, Non-selective angiocardiography confirmed a dilated coronary sinus with persistent left cranial vena cava, The right cranial vena cava was absent, The dog was clinically normal and the unusual vessel was an incidental finding

  5. Venous return curve and its application to assessment of the effect of cardiovascular drugs

    Energy Technology Data Exchange (ETDEWEB)

    Nagashima, Kenshi; Gotoh, Kohshi; Yagi, Yasuo (Gifu Univ. (Japan). Faculty of Medicine) (and others)

    1990-01-01

    In an effort to obtain a venous return curve, occlusion plethysmography with radionuclide was performed in the forearm of 24 patients with various heart diseases. Radionuclide angiocardiography was performed and during the equilibrium phase the region of interest was created over the forearm for repeated venous occlusions. Specific compliance in the vein of the forearm was obtained by drawing the radionuclide count-venous pressure curve from changes in venous pressure and radioactivity of the forearm. Compliance of human systemic veins was then obtained based on some hypotheses. Mean systemic pressure (Pms) was estimated. In addition, right auricular pressure and cardiac output were obtained for drawing part of the venous return curve. In a study of the effect of cardiovascular drugs on the venous return curve, Pms was found to be significantly decreased by the administration of nitroglycerin. Furthermore, systemic venous return curve moved to the leftward. In contrast, nifedipine did not have any influence on Pms in Class I of cardiovascular function; and systemic venous return curve moved clockwise by the administration of the drug. In the case of Class II or III, nifedipine caused the systemic venous return curve to move clockwise with decreasing Pms. (N.K.).

  6. Venous return curve and its application to assessment of the effect of cardiovascular drugs

    International Nuclear Information System (INIS)

    In an effort to obtain a venous return curve, occlusion plethysmography with radionuclide was performed in the forearm of 24 patients with various heart diseases. Radionuclide angiocardiography was performed and during the equilibrium phase the region of interest was created over the forearm for repeated venous occlusions. Specific compliance in the vein of the forearm was obtained by drawing the radionuclide count-venous pressure curve from changes in venous pressure and radioactivity of the forearm. Compliance of human systemic veins was then obtained based on some hypotheses. Mean systemic pressure (Pms) was estimated. In addition, right auricular pressure and cardiac output were obtained for drawing part of the venous return curve. In a study of the effect of cardiovascular drugs on the venous return curve, Pms was found to be significantly decreased by the administration of nitroglycerin. Furthermore, systemic venous return curve moved to the leftward. In contrast, nifedipine did not have any influence on Pms in Class I of cardiovascular function; and systemic venous return curve moved clockwise by the administration of the drug. In the case of Class II or III, nifedipine caused the systemic venous return curve to move clockwise with decreasing Pms. (N.K.)

  7. The value of 64-slice spiral CT angiography based on pre-contrasted raw data in diagnosing pulmonary arteriovenous fistula

    International Nuclear Information System (INIS)

    Objective: To evaluate the value of 64-slice spiral CT angiography based on pre- contrasted raw data in diagnosing pulmonary arteriovenous fistula. Methods: 64-slice spiral CT plain scan and enhanced scan was performed in 16 patients with pulmonary arteriovenous fistula, pulmonary angiography based on pre-contrast and post-contrast raw data was performed respectively, including maximum intensity projection (MIP), shaded-surface display (SSD), and volume rendering (VR). According to the results of angiocardiography and surgical findings, comparson of the three methods was made in the display of PAVF in pre-contrast and post-contrast phase images. Results: 8 of the 16 PAVF cases were single lesion, 8 cases were multi-lesions. 30 PAVF lesions were found in all the patients. MIP, SSD and VR based on pre-contrast raw data displayed PAVF lesions in 20, 14, and 22, respectively. The combination of the 3 methods based on pre-contrast raw data could show 26 PAVF lesions. MIP, SSD, and VR based on post-contrast raw data displayed PAVF lesions in 24, 18, and 30, respectively. The combination of the 3 methods based on post-contrast raw data could show 30 PAVF lesions. Conclusion: 64-slice spiral CT angiography based on pre-contrasted raw data can clearly show the position, number, and shape of PAVF lesions, which is of great value in diagnosing PAVF. (authors)

  8. Accuracy of deconvolution algorithms assessed by simulation studies: concise communication

    International Nuclear Information System (INIS)

    Deconvolution has been used to correct first-pass radionuclide angiocardiography for the time course of the delivery of radiopharmaceutical into the cardiopulmonary system. The extreme sensitivity of deconvolution to random errors in the data may account for some of the problems encountered in practice. We implemented several deconvolution algorithms that were suitable for use with the unimodal and multimodal superior vena caval and pulmonary curves found in left-to-right shunt quantification. The sensitivity of the algorithms to random errors was assessed using mathematical test problems degraded with pseudorandom noise. An algorithm that constrained the deconvolved pulmonary curve to be expressable as the non-negative sum of a set of lagged normal curves was found to have the smallest maximum error on the curves tested. Comparison with results from a previously published test problem indicated an error reduction of greater than 50% over previously used algorithms. Use of this algorithm may permit more accurate deconvolution of pulmonary time-activity curves and thereby improve shunt quantification

  9. Magnetic resonance imaging of congenital cardiac abnormalities

    International Nuclear Information System (INIS)

    Magnetic resonance imaging will not replace echocardiography as the simplest and most definitive method of establishing a noninvasive diagnosis in young patients with congenital cardiac malformations, nor will it replace radionuclide angiography for relatively noninvasive detection and quantitation of cardiac shunts. Magnetic resonance imaging is a complementary noninvasive imaging procedure that can answer some questions left in doubt by echocardiography (mainly extracardiac artery and vein assessments) or radionuclide angiography and used as a preferred follow-up imaging method in certain clinical circumstances. In addition, MRI can be a first-line modality for cardiovascular imaging in older patients in whom adequate echo windows are not available. Angiocardiography remains necessary to provide vital physiological data, i.e., chamber pressures, shunt volumes, oxygen saturations, and pulmonary vascular resistance; however, MRI could negate some follow-up catheterizations in appropriate clinical circumstances. High-resolution proton MRI tomography should ultimately permit the accurate evaluation of ventricular volumes, myocardial mass, and the assessment of regional wall motion and ejection fractions. Paramagnetic substances such as manganese ion may ultimately provide a basis for myocardial perfusion imaging. The potential for MRI evaluation of tissue characterization, noninvasive blood-flow measurements, and myocardial metabolism assessment in intriguing and awaits clinical evaluation

  10. Radionuclide assessment of left ventricular diastolic function in patients with mitral stenosis before and after percutaneous transvenous mitral commissurotomy; Use of list mode method in patients with atrial fibrillation

    Energy Technology Data Exchange (ETDEWEB)

    Nakamura, Seishi; Iwasaka, Toshiji; Kimura, Yutaka; Ohkubo, Naohiko; Matsuura, Takashi; Inada, Mitsuo; Shiraishi, Tomokuni (Kansai Medical School, Moriguchi, Osaka (Japan))

    1991-07-01

    To evaluate the effect of percutaneous transvenous mitral commissurotomy (PTMC), equilibrium radionuclide angiocardiography was performed in eight patients with mitral stenosis who had atrial fibrillation. Accurate cardiac function in patients with atrial fibrillation is difficult to assess, since the wide fluctation of cardiac cycle makes the ventricular hemodynamics variable. A new processing algorhythm was devised to make multiple gated images discriminated from a heart rate distribution histogram. We obtained about 1,000 beats data by list mode acquisition, and processed a heart rate distribution histogram. The data in the area {+-}5% of the most frequent heart rate were converted into frame mode and a representative time activity curve was derived. Mitral valve area calculated by echocardiography increased from 1.3{+-}0.5 to 2.0{+-}0.6 (cm{sup 2}) significantly (p<0.01). The mean transmitral pressure gradient measured by catheterization decreased from 12.4{+-}5.9 to 4.9{+-}3.7 (mmHg) significantly (p<0.01) and the clinical symptoms improved in all patients. The change in left ventricular ejection fraction from 43{+-}9 to 48{+-}13 (%) was not statistically significant, but peak filling rate (PFR) derived from the time activity curve increased from 1.5{+-}0.3 to 2.0{+-}0.4 (EDV/sec) significantly (p<0.01). Thus PFR is a noninvasive parameter that can evaluate the effect of PTMC. (author).

  11. Hemodynamic effects of metoprolol and nifedipine in angina pectoris measured by isotope technique

    Energy Technology Data Exchange (ETDEWEB)

    Bostroem, P.A.

    1988-01-01

    In order to evaluate the therapeutic effects of metoprolol, nifedipine, and their combination, 11 patients with secondary angina pectoris and with thallium tomographic findings indicating coronary artery disease were studied before and after these three treatment regimes in a single-blind cross-over study. The therapeutic effect was measured by standardized working test and isotope angiocardiography, which enabled evaluation of left ventricular ejection fraction, stroke volume, and phase analysis of left ventricular contraction. Treatment with metoprolol and combination therapy increased work performance. Ejection fraction did not differentiate the treatment regimes, whereas stroke volume was significantly lower at work and heart rate higher at rest and at work during nifedipine treatment compared to either metoprolol or combination treatment (p less than 0.05). Cardiac output was significantly reduced during nifedipine and metoprolol treatment during work (p less than 0.05). Phase improved after all therapeutic regimes, but reached significance only during the metoprolol treatment period at rest (p less than 0.05).

  12. Hemodynamic effects of metoprolol and nifedipine in angina pectoris measured by isotope technique

    International Nuclear Information System (INIS)

    In order to evaluate the therapeutic effects of metoprolol, nifedipine, and their combination, 11 patients with secondary angina pectoris and with thallium tomographic findings indicating coronary artery disease were studied before and after these three treatment regimes in a single-blind cross-over study. The therapeutic effect was measured by standardized working test and isotope angiocardiography, which enabled evaluation of left ventricular ejection fraction, stroke volume, and phase analysis of left ventricular contraction. Treatment with metoprolol and combination therapy increased work performance. Ejection fraction did not differentiate the treatment regimes, whereas stroke volume was significantly lower at work and heart rate higher at rest and at work during nifedipine treatment compared to either metoprolol or combination treatment (p less than 0.05). Cardiac output was significantly reduced during nifedipine and metoprolol treatment during work (p less than 0.05). Phase improved after all therapeutic regimes, but reached significance only during the metoprolol treatment period at rest (p less than 0.05)

  13. Radiation doses and correlated late effects in diagnostic radiology

    International Nuclear Information System (INIS)

    Patient irradiation in diagnostic radiology was estimated from measurements of absorbed doses in different organs, assessment of the energy imparted and retrospective calculations based on literature data. Possible late biological effects, with special aspects on children, were surveyed. The dose to the lens of the eye and the possibility of shielding in carotid angiography was studied as was the absorbed dose to the thyroid gland at cardiac catheterization and angiocardiography in children. Calculations of the mean bone marrow dose and gonad doses were performed in children with chronic skeletal disease revealing large contributions from examinations of organs other than the skeleton. The dose distribution in the breast in mammography was investigated. Comparison of the energy imparted in common roentgen examinations in 1960 and 1975 showed an unexpected low decrease in spite of technical improvements. Reasons for the failing decrease are discussed. The energy imparted to children in urological examinations was reduced significantly due to introduction of high sensitivity screens and omission of dose demanding projections. Contributions to the possible late effects were estimated on the basis of the organ doses assessed. (author)

  14. Physiologic response of canine hearts to change in size of dose per fraction

    International Nuclear Information System (INIS)

    Eighty dogs were assigned randomly to three groups which received variable total doses given in either 2,3 or 4 Gy fractions. All doses were delivered in a four-week period. There were three or four dogs at each dose level. Hearts were irradiated with 5 MV x rays given through parallel opposed lateral portals. Echocardiography was used to determine the presence of pericardial effusion, cardiac contractility and wall thickness. Angiocardiography was used to determine stroke volumes and ejection fractions. Dose response curves were plotted for each of the three different size of dose per fraction groups. Isoeffective doses were determined from the dose response plots. Six months after irradiation, the dose with a 50% probability for causing measurable pericardial effusion decreased from 67.3 Gy to 49.5 Gy when the size of dose per fraction was increased from 2 Gy to 4 Gy. Other isoeffects were affected to a similar degree. Alpha/beta ratios calculated from isoeffect plots were about 3 Gy for most parameters

  15. Right ventricular ejection fraction validation of first-pass radionuclide studies by contrast angiography

    International Nuclear Information System (INIS)

    The accuracy of first-pass radionuclide angiocardiography (FPRNA) in the assessment of right ventricular ejection fraction (RVEF) using a multicrystal scintillation camera in the right anterior oblique view has not been reported. To test the validity of this technique, RVEFs derived from first-pass time-activity curves with and without background correction were compared with those obtained from contrast ventriculography in 36 patients. Background regions-of-interest tested included tricuspid valve, free wall, and horseshoe-shaped approaches. The tricuspid valve approach yielded a mean RVEF of 0.485+-0.100 (SD) which slightly underestimated the contrast mean value (0.553+-0.099, p0.05) but correlated less well (r=0.77). With the method without background correction, a much lower mean value (0.387+-0.081, p<0.01) and less correlation (r=0.77) were obt ained. Thus, FPRNA using a multicrystal camera in the right anterior oblique view is a reliable technique for measuring RVEF when a tricuspid valve or horseshoe-shaped background approach is employed, but is less accurate if the time-activity curve without background correction is applied. (author)

  16. In vivo/in vitro labeling of red blood cells with sup(99m)Tc and clinical applications

    International Nuclear Information System (INIS)

    A reliable and stabile in vivo/in vitro labeling technique of red blood cells (RBC) is described. The patients are injected 20% of the content of an unlabeled kit used for bone scintigraphy (TechneScan PYP, Byk-Mallinckrodt). 15 minutes later 3 ml blood are sampled in a heparinized syringe. The blood is incubated together with 30-40 mCi (1-1.5 GBq) sup(99m)Tc for 10 minutes in a water bath at 35-370C. After centrifugation at 500 g a dose of 15-25 mCi (0.6-1 GBq) sup(99m)Tc labeled RBC may be withdrawn in a volume of 1-1.5 ml. Mean labeling efficiency is 88%, without using the first eluat of a Tc-generator the yield is as high as 92%. Due to the small volume, the labeled RBC may be reinjected as bolus and first pass radionuclide angiocardiography can be performed. Using labeled RBC, scintigraphy of the intravasal space is possible up to 20 hours without deterioration in contrast or accumulation of radioactivity in the extravasal space or in other organs. Evaluation of heart function can be performed up to 10 hours. In addition, labeled RBC are useful in detecting unknown gastrointestinal bleeding. (orig.)

  17. Alteration of Peripheral Blood T-Reg Cells and Cytokines Production in Angiography Personnel Exposed to Scattered X-Rays

    Directory of Open Access Journals (Sweden)

    Ebrahim Torkabadi

    2007-12-01

    Full Text Available Angiocardiography is an X-ray examination of the blood vessels or chambers of the heart. Cardiologists and staff members applying this procedure are exposed to high levels of scattered radiation. In our previous study the incidence of unstable chromosomal aberrations and cytokinesis-blocked micronuclei were found to be significantly higher in exposed individuals than the age and sex matched controls. In the present study we assessed cytokine production by peripheral blood mononuclear cells of the above cases and the percentage of Treg cells. According to film dosimeter analysis, personnels received 0.25-15 mSv during the previous year (average of 3 mSv/y. Isolated PBMCs from the test and control groups were stimulated with Phorbol Myristate Acetate/ Ionomycin (PMA/I. Cytokine production was measured in the supernatants of cultured lymphocytes. The percentage of Treg cells was studied by flow cytometry. The production of IL-10 and IL-5 was significantly down-regulated in the test group compared to the control group. In contrast, IL-12 was up-regulated. Yet, no statistically significant difference was found for IFN- γ between two groups. In addition, we found higher percentage of CD4+CD25+bright Treg cells in the study group compared to the controls. Taken together, it was shown that low doses of scattered X-rays could skew cytokine profile of peripheral blood mononuclear cells in favour of inflammatory response causing the increase of Treg cells.

  18. Magnetic resonance imaging in complete type endocardial cushion defect

    International Nuclear Information System (INIS)

    Objective: To evaluate the value and limitation of magnetic resonance imaging (MRI) in complete type endocardial cushion defect (ETECD). Methods: Eight patients (male 5, female 3) were scanned by MRI with ECG-gated spin echo (SE) and gradient echo (GE) cine techniques. The diagnosis of CTECD was made by X-ray plain film, echocardiography, X-ray right cardiac catheterization and angiocardiography, as well as MRI four patients were treated with operation. Results: Every chamber of the heart was enlarged, more serious in the right atrium and ventricle, with thickening of right ventricular wall on MRI in majority of cases. The endocardial cushion disappeared, so the four chambers of the heart were directly connected with each other, and presented a cross shape. Ventricular septal membrane defect and type I atrial septal defect were depicted also. The normal structure of mitral and tricuspid valves were not intact. There were 6 cases with pulmonary hypertension, 2 cases with Tetralogy of Fallot, 4 cases with right aorta arch and descending aorta, 1 patient with dextroverted heart and another with persistent left superior vena cava connected with coronary sinus. The cine MRI could directly depict the situation of left-right or right-left shunt at atrial and ventricular levels, and regurgitation from ventricles to atria, meanwhile the valves were depicted clearly. Conclusions: MRI can clearly demonstrate all anatomic deformation and complicated hemodynamic change of CTECD, as well as other coexistent deformations

  19. Angiography of double outlet of right ventricles%右心室双出口的心血管造影诊断

    Institute of Scientific and Technical Information of China (English)

    申玉良; 侯爱军; 武艳强; 袁芳

    2012-01-01

    目的 评价心血管造影对右心室双出口的诊断价值.方法 收集11例右心室双出口患者的临床及心血管造影资料并进行回顾性分析.全部患者均行X线、心电图、超声心动图心导管及心血管造影检查.结果 所有患者的心血管造影诊断与术后诊断完全相符,符合率为100%.11例主动脉、肺动脉同时显影,两大动脉起自右心室.8例室间隔缺损,3例心内膜垫缺损.其中5例室间隔缺损位于肺动脉瓣下,同时并右冠状动脉异位开口;3例室间隔缺损位于主动脉、肺动脉之间,同时合并左右心房互换、永存左上腔静脉;2例室间隔缺损远离肺动脉和主动脉,肺动脉发育差.另1例心内膜垫缺损合并二尖瓣、三尖瓣重度关闭不全.结论 心血管造影对右心室双出口及合并畸形可做出较准确诊断.%Objective To report 11 cases of double outlet of right ventricles and to evaluate the methods of angiography.Methods Angiocardiographies of 11 patients were collected.All patients underwent X-ray film,electro-cardiography,echocardiography,cardiac catheterization and angiocardiography.Results The coincidence rate between angiography and operation was 100%.Angiographies were performed in 11 patients.Both great arteries(Aorta and Pulmonary Artery) originated from the right ventricle in all the cases.8 patients had ventricular septal defect(VSD) and 3 patients had endocardial cushion defect.Five cases of the VSDs were found under the valve of pulmonary artery and were accompanied with anomalous origin of the right coronary artery;3 cases of the VSDs were found to be between the aorta and pulmonary artery and were accompanied with position interchange of two atria and persistent left superior vena cava;2 eases of the VSDs were found being away from aorta and pulmonary artery as well as agenesis of pulmonary artery.The last case of the endocrinal cushion defect were accompanied with mitral valve insufficiency and severe

  20. New Coaxial Transseptal Needle for Creation of Atrial Septal Defects in Adult Sheep

    International Nuclear Information System (INIS)

    Objectives: To introduce a new transseptal (TS) needle assembled in our laboratory—the coaxial TS (CTS) needle—and describe our experience with it in creating experimental atrial septal defects (ASD) in adult sheep.BackgroundWith commercially available TS needles, we were not able to consistently perform TS puncture at the fossa ovalis in adult sheep.Material and MethodsTen adult sheep with a mean weight of 63.5 kg were used. The CTS needle consists of four components: a 9F Teflon catheter, a 14-gauge blunt curved-tip metal cannula, a 4F tapered catheter, and a 20-gauge open needle. A transjugular 5F pigtail catheter was used to display the septal anatomy by angiocardiography and was left in place to mark the level of the fossa ovalis. The septum was then probed by a transfemoral 5F curved-tip end-hole catheter. The CTS needle was aligned with the tip of the transjugular catheter, and the TS puncture was performed under fluoroscopic guidance. After documenting a left atrial position, a balloon angioplasty catheter was used for creation of the ASD. Results: A small patent foramen ovale was discovered by septal probing in one sheep. All sheep underwent successful TS punctures without complications. The ASD size ranged from 13 to 15 mm. In eight sheep, the ASD was in fossa ovalis. In the first two sheep where the needle was not well aligned with the marking catheter, the ASD was in the septum secundum. No damage to the atrial or other heart structures was found at necropsy. Conclusion: The CTS needle is a suitable needle for TS puncture and ASD creation in adult sheep. Proper alignment of the CTS needle with a catheter marking the fossa ovalis is essential for successful puncture.

  1. Congenital abnormalities of the aorta in children and adolescents; Angeborene Fehlbildungen der Aorta im Kindes- und Jugendalter

    Energy Technology Data Exchange (ETDEWEB)

    Eichhorn, J.G. [Universitaetskinderklinik Heidelberg, Abt. Paediatrische Kardiologie, Heidelberg (Germany); Ley, S. [Deutsches Krebsforschungszentrum (DKFZ) Heidelberg, Abt. Radiologie, Heidelberg (Germany); Radiologische Universitaetsklinik Heidelberg, Abt. Paediatrische Radiologie, Heidelberg (Germany)

    2007-11-15

    Aortic abnormalities are common cardiovascular malformations accounting for 15-20% of all congenital heart disease. Ultrafast CT and MR imaging are noninvasive, accurate and robust techniques that can be used in the diagnosis of aortic malformations. While their sensitivity in detecting vascular abnormalities seems to be as good as that of conventional catheter angiocardiography, at over 90%, they are superior in the diagnosis of potentially life-threatening complications, such as tracheal, bronchial, or esophageal compression. It has been shown that more than 80% of small children with aortic abnormalities benefit directly from the use of noninvasive imaging: either cardiac catheterization is no longer necessary or radiation doses and periods of general anesthesia for interventional catheterization procedures can be much reduced. The most important congenital abnormalities of the aorta in children and adolescents are presented with reference to examples, and the value of CT and MR angiography is documented. (orig.) [German] Fehlbildungen der Aorta gehoeren zu den haeufigen kongenitalen kardiovaskulaeren Malformationen (15-20% aller angeborenen Herzfehler). Die raeumlich und zeitlich hochaufloesenden Methoden der Computer- (CT-) und Magnetresonanztomographie (MRT) sind nichtinvasive, hochwertige und aussagekraeftige Methoden zur Diagnostik angeborener Fehlbildungen der Aorta. Sie zeigen sich in der Diagnostik der Gefaessanomalien gleichwertig zur konventionellen Angiographie mit Sensitivitaeten von mehr als 90%. In der Diagnostik assoziierter Komplikationen, wie trachealen, bronchialen oder oesophagialen Kompressionen, sind sie ueberlegen. Es konnte gezeigt werden, dass 80% der Kleinkinder mit Fehlbildungen der Aorta einen direkten Vorteil von der nichtinvasiven Bildgebung hatten: Entweder war eine Herzkatheterung fuer die Therapieplanung nicht mehr erforderlich oder die Durchleuchtungs- und Narkosezeiten bei der Katheterintervention konnten deutlich verkuerzt

  2. Evaluation of left ventricular morphology and function by cardiac computed tomographic examination

    International Nuclear Information System (INIS)

    One hundred and forty-nine adult cases of various heart diseases were examined with ungated scans covering whole left ventricular (LV) and ECG-gated scans. In gating examination, ''long-axial'' and ''short-axial'' slices were scanned and end-diastolic area (EDA), end-systolic area (ESA) and ''mean'' area (MA) were obtained in each slices. With regard to LV morphology, wall thickening in HCM and wall thinning and mural thrombus in myocardial infarction were easily visualized. LV ''mean'' volume (LVMV) was easily calculated from the sum of sliced LV volume of ungated scans. The LVMV was well correlated with end-diastolic volume (EDV) obtained by LV angiocardiography (LVG) (r = 0.91), though the former was somewhat smaller than the latter. EDV by CT obtained after the correction with MA/EDA from gating examination showed a better correlation (r = 0.95) and both EDV showed almost the same value. LV ejection fraction (EF) was calculated by exchanging ESA/EDA to ESV/EDV in ''long-axial'' and ''short-axial'' gated slices, and ''long-axial'' EF, ''short-axial'' EF and mean of both were well correlated with LVEF of LVG (r = 0.73 - 0.79). LVEF calculated from ''long-axial'' EDA and ESA by application of ''area-length'' method was also correlated with EF of LVG (r = 0.68), but these EDV and ESV were smaller than those of LVG due to shorter long-diameter of LV in CT. LV muscle volume was calculated from sum of sliced muscle volumes of ungated scans covering LV, and LV mass was easily evaluated from LV muscle volume and specific gravity of LV muscle. This LV mass was well correlated with that of LVG (r = 0.90) and the absolute values were almost the same. (J.P.N.)

  3. Comparison of nifedipine gastrointestinal therapeutic system and atenolol on antianginal efficacies and exercise hemodynamic responses in stable angina pectoris.

    Science.gov (United States)

    Wallace, W A; Wellington, K L; Chess, M A; Liang, C S

    1994-01-01

    A gastrointestinal therapeutic system (GITS) of nifedipine has been developed to provide a once-daily dosing, and predictable, relatively constant plasma concentrations. This study compared the antianginal efficacy of nifedipine GITS with a once-a-day beta-receptor blocker, atenolol. Seventeen patients with documented coronary artery disease and stable stress-induced angina pectoris were studied during a 2-week, single-blind, placebo baseline phase and a 12-week randomized, double-blind, active drug crossover efficacy phase, using the bicycle exercise test and ambulatory electrocardiographic recordings. Patients exercised significantly longer with nifedipine GITS (883 +/- 47 seconds) and atenolol (908 +/- 44 seconds) than with placebo (794 +/- 41 seconds). Nifedipine GITS reduced systolic blood pressure at all stages of exercise compared with placebo but, because heart rate tended to increase more during nifedipine therapy, there was no difference in rate-pressure products between the placebo and nifedipine GITS periods. In contrast, atenolol reduced heart rate, systolic blood pressure and rate-pressure product during exercise compared with placebo. Whereas left ventricular ejection fractions (by radionuclide angiocardiography) increased with exercise, the maximal increase was smaller with atenolol than with placebo and nifedipine. The net increase in left ventricular ejection fraction at the end of exercise was greater with nifedipine than with placebo or atenolol. Ambulatory electrocardiograms showed only a small number of ischemic events. Neither nifedipine GITS nor atenolol reduced the number of ischemic events or total duration of ST-segment deviations significantly. It is concluded that nifedipine GITS is as effective an antianginal agent as atenolol, but the hemodynamic effects of the 2 agents differ.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:8279372

  4. The Ross Procedure in Patients among the Pediatric Population, Post Ten Years of Experience

    Directory of Open Access Journals (Sweden)

    Andrey A. Ivanov

    2013-09-01

    Full Text Available The aim of the study was to analyze the results of the surgical treatment in pediatric patients who had undergone the Ross procedure.Material and Methods: The study involved 114 patients between 12 days to 18 years in age. The early and late (up to 5 years results of the treatment were studied. The examination included echocardiography, catheterization of the cardiac chambers and angiocardiography. The case distribution of patients based on diagnosis was as follows: isolated aortic valve stenosis (IAVS in 38 (33.3% patients, aortic valve insufficiency (AVI in 33 (28.9%, and combined heart defects in 56 patients (49.1%.Results: The death rate was 6.14% during the early postoperative period and 1.14% in the late postoperative period; the actuarial survival in the long-term was 98.86%. The complication rate was 51.5%. The most frequent complication was pericarditis (25.6%, whereas cardiac and respiratory failure occurred in 7.6% of the cases and cardiac arrhythmias in 6.1% of the cases. The average time spent in the intensive care unit was 3.48 ± 2.90 days; the hospitalization period on average was 24.70±10.87 days. After surgery, there was a tendency of the echocardiographic parameters to move toward normalization. The frequency of reoperation in the late period was 23.7%, the main reason for which being the conduit dysfunction in the position of the pulmonary artery (PA.Conclusion: The clinical efficacy of the Ross procedure in the treatment of aortic valve malformations in the pediatric group was confirmed. However, in some cases, the need to perform repeated operations due to the increase in the ring size and an increase in the neo-aortic insufficiency during the somatic growth process.

  5. Severity and extent of coronary artery disease and their relationship to left ventricular functional reserve in the chronic disease state

    International Nuclear Information System (INIS)

    This study evaluated the usefulness of EF, MPD and the first-third filling fraction (FF, divided by the volume accrued throughout diastole) at rest and during stress, using ergometer and first-pass radionuclide angiocardiography (RNA), to determine the severity of CAD, and to evaluate any abnormalities in the systolic and diastolic coupling in left ventricular function during stress. Seventy-four patients with significant CAD, including 41 with previous transmural MI (MI group) and 33 without MI (angina group) were the subjects of this study. EF at rest and during stress inversely correlated, and MPD on stress linearly correlated with PS in angina group with PS > 10, while no such correlations were found in MI group. A normal EF response (ΔEF ≥ 5 %) was accompanied by a greater-than-normal response in FF (ΔFF) in both groups. A lower EF response was accompanied by a smaller ΔFF in angina group, but by a larger ΔFF in MI group. The difference was statistically significant (p < 0.03), without significant differences by age, PS, peak heart rate, systolic blood pressure, and ischemia on ECG during stress. Resting EF and FF by the RNA method correlated with those by left ventriculography (LVG), respectively. It was suggested that RNA is an accurate method for determining EF and FF, while phase analysis may provide some additional information different from that provided by LVG. We concluded that EF and MPD during stress are as useful as ΔMPD with the exception of a few cases in predicting the severity of CAD, and that scar tissue within the ventricular wall in MI may play an important role in determining the ventricular diastolic mechanical property during stress. (J.P.N.)

  6. Pulmonary arterial hypertension in congenital heart disease: Correlation of radiologic index with hemodynamic data

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Young Hi [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    1984-09-15

    It is well known that pulmonary arterial hypertension in congenital heart disease is an important prognostic factor, as is pulmonary vascular resistance. So it is tempting to get certain radiologic index that could predict the presence and the degree of pulmonary arterial hypertension. A total of 152 cases of left to right shunt with pulmonary arterial hypertension and 50 cases of left to right shunt without pulmonary arterial hypertension is presented, in which cardiac catheterization and angiocardiography were done at the Department of Radiology, Seoul National University Hospital between March 1981 and February 1983. Statistical analysis of plain radiography findings with the emphasis on the correction of radiologic index with the hemodynamic data. The results are as follows: 1. The incidence of pulmonary arterial hypertension is much less in arterial septal defect than other two disease groups of left to right shunt. 2. PA/T ratio correlates well with pulmonary arterial pressure (r=0.674), especially in mild pulmonary hypertension group. No correlation in moderate pulmonary hypertension group in significant level. 3. PA/T ratio is below 38 in total cases of normal control group and in 32 cases (21.0%) among 152 cases of pulmonary arterial hypertension group. 4. The average PA/T ratio in normal pressure group of left to right shunt is 35.3, which has no significant difference from that of normal control group. 5. The average CT ratio of pulmonary arterial hypertension group is 59.0, which is larger than 49.1 of normal control group. The CT ratio shows no correlation with the pulmonary arterial pressure in statistically significant level. 6. The higher the pulmonary arterial pressure, the larger the Rp/Rs value. The Rp/Rs in atrial septal defect is 0.193 in average, the lowest value in comparison with other two disease groups.

  7. Cardiomyopathy in a Harris hawk (Parabuteo unicinctus).

    Science.gov (United States)

    Brandão, João; Reynolds, Caryn A; Beaufrère, Hugues; Serio, Jacqueline; Blair, Robert V; Gaschen, Lorrie; Johnson, James G; Del Piero, Fabio; Barker, Steven A; Nevarez, Javier G; Tully, Thomas N

    2016-07-15

    CASE DESCRIPTION An adult sexually intact female Harris hawk (Parabuteo unicinctus) housed at a wildlife hospital was evaluated because of acute collapse during an educational exhibition. CLINICAL FINDINGS Physical examination and hematologic analysis revealed no abnormalities; radiography revealed findings consistent with a previous tibiotarsal fracture. Coelioscopy with histologic examination and fungal culture of lung and air sac samples revealed anthracosis but no fungal infection. The hawk was discharged and temporarily removed from the education program; 1 month later, upon reintroduction into the program, it collapsed again. Physical examination and hematologic findings were similar to those after the first episode. Transcoelomic and transesophageal echocardiography and CT angiocardiography findings were consistent with cardiomyopathy. TREATMENT AND OUTCOME Initial cardiac treatment included furosemide (0.5 mg/kg [0.23 mg/lb], PO, q 24 h) and pimobendan (10 mg/kg [4.5 mg/lb], PO, q 12 h). After 10 days of treatment, peak and trough plasma concentrations of pimobendan were measured at 25, 196 and 715.97 ng/mL, respectively; the dosage was decreased to 0.25 mg/kg (0.11 mg/lb), PO, every 12 hours. No overt signs of toxicosis were detected. A sample was collected to reevaluate plasma pimobendan concentration after 30 days of treatment; results were not obtained prior to the patient's death but revealed a peak concentration of 16.8 ng/mL, with an undetectable trough concentration. The hawk was found dead 6 months after initial evaluation. Necropsy revealed cardiomegaly, but histologic examination did not reveal an inciting cause of cardiac dysfunction. CLINICAL RELEVANCE Cardiac disease in raptors may be underreported. Transcoelomic and transesophageal echocardiography and CT angiography provided useful information for the diagnosis of cardiac disease in the hawk of this report. PMID:27379599

  8. ENDOMYOCARDIAL FIBROSIS IN CHINA

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Purpose.To introduce the epidemical, pathological, and clinical characteristics as well as the diagnostic and therapeutical experiences of endomyocardial fibrosis(EMF) in China. Data sources.A CMBdisc search was done of the Chinese-language literature published from January 1983 through June 1997 about EMF and/or restrictive cardiomyopathy. A manual search was then done for other contributions, including abstracts, between January 1965 and June 1997.Results. Eighty-seven Chinese cases of EMF were collected in this paper. There were 49 men and 38 women, with a mean age of 28±13 years(range, 8 to 68 years). The distribution of the cases is mainly in the south of China. Combined right and left ventricular disease occurs in 48 percent of cases, with pure right ventricular involvement occurring in 42 percent and pure left ventricular involvement in the remaining 10 percent of patients who are examined postmortem. The diagnosis of EMF was confirmed in 21 cases at autopsy, and in 66 cases by echocardiography, angiocardiography, and/or endomyocardial biopsy which showed the characteristic changes. Clinically, right-sided disease is the commonest variety. Endocardiectomy and tricuspid(n=7) or mitral(n=1) valves replacement have been performed in 8 patients. There were 2 operative deaths. Six patients had a satisfactory recovery postoperatively and living well in the follow-up duration. Conclusion.EMF has been diagnosed clinically and confirmed at necropsy in a number of cases in the south of China. The etiology, incidence and epidemiology are still unknown. The pathological and clinical features are similar to those in tropical areas, but right ventricular involvement is the commonest type in our country.

  9. Routine preoperative cardiac catheterization necessary before repair of secundum and sinus venosus atrial septal defects

    International Nuclear Information System (INIS)

    Between January 1976 and July 1983, 217 patients with atrial septal defect underwent surgical repair at Children's Hospital. Thirty with a primum atrial septal defect and 26 who underwent cardiac catheterization elsewhere before being seen were excluded from analysis. Of the 161 remaining patients, 52 (31%) underwent preoperative cardiac catheterization, 38 because the physical examination was considered atypical for a secundum atrial septal defect and 14 because of a preexisting routine indication. One hundred nine (69%) underwent surgery without catheterization, with the attending cardiologist relying on clinical examination alone in 5, additional technetium radionuclide angiocardiography in 5, M-mode echocardiography in 13 and two-dimensional echocardiography in 43; both M-mode echocardiography and radionuclide angiography were performed in 24 and two-dimensional echocardiography and radionuclide angiography in 19. Since 1976, there has been a trend toward a reduction in the use of catheterization and use of one rather than two noninvasive or semiinvasive techniques for the detection of atrial defects. Of the 52 patients who underwent catheterization, the correct anatomic diagnosis was made before catheterization in 47 (90%). Two patients with a sinus venosus defect and one each with a sinus venosus defect plus partial anomalous pulmonary venous connection, partial anomalous pulmonary venous connection without an atrial septal defect and a sinoseptal defect were missed. Of 109 patients without catheterization, a correct morphologic diagnosis was made before surgery in 92 (84%). Nine patients with a sinus venosus defect, three with sinus venous defect and partial anomolous pulmonary venous connection, four with partial anomalous pulmonary venous return without an atrial septal defect and one with a secundum defect were incorrectly diagnosed.(ABSTRACT TRUNCATED AT 250 WORDS)

  10. 双源计算机断层扫描在永存动脉干诊断中的应用%Clinical application of dual-source CT in diagnosis of persistent truncus arteriosus

    Institute of Scientific and Technical Information of China (English)

    冯越; 刘铁; 翟利浩

    2012-01-01

    Objectives To explore the clinical values of dual - source computed tomography ( CT) in diagnosis of persistent truncus arteriosus(PTA). Methods Seven patients (aged 7 days to 8 years, middle age 3.4 years) diagnosed as PTA by echocardiography underwent cardiac CT with dual-source CT machine. Two- and three-dimensional images were reformated by multiple planar reformation (coronal, sagital and oblique), maximum intensity projection and volume rendering. Of the 7 patients, 4 underwent angiocardiography. Results Qualitative and classification diagnosis were made through Dual-source CT in all the 7 cases. Dual-source CT visualized 28 concomitant anomalies while echocardiography visualized 24 in all the 7 cases. Conclusions Qualitalive and classification diagnosis can be made through Dual-source CT which contributes to the strategies and improvement of operations.%目的 探讨双源计算机断层扫面(computed tomography,CT)在永存动脉干诊断中的应用价值.方法 选择7例经超声心动图诊断为永存动脉干患者,年龄7d~8岁,中位年龄3.4岁.采用双源CT,心电门控下对比增强完成心脏检查,并在图像工作站完成多平面(MPR)、最大密度投影(MIP)和三维容积漫游(VR)处理.其中有4例进行心导管检查.结果 双源CT对7例永存动脉干均作出定性诊断和分型诊断,共发现合并畸形28处.超声心动图共显示24处.结论 双源CT可以对永存动脉干患者作出准确诊断及分型,并有助于临床手术方案的制订与完善.

  11. The influence of anatomic variance in the coronary artery on cardiac function with PCI after acute inferior wall myocardial infarction

    International Nuclear Information System (INIS)

    Objective: To analyze the influence in anatomic variance of coronary artery on function of left and right ventricles after acute inferior myocardial infarction (AIMI) treated with percutaneous coronary intervention therapy (PCI). Methods: Forty-seven inferior AIMI patients were divided into 2 groups: 12 left dominant group [including equipollent case, i.e. inferior wall of left ventricle supplied by left circumflex coronary artery (LCX), right ventricle by right coronary artery (RCA)] and 35 right dominant group (both inferior wall and right ventricle were supplied by RCA). Equilibrium radionuclide angiocardiography (ERNA) and myocardial perfusion imaging (MPI) were used for comparing the influence between different coronary artery flow patterns on biventricular hemodynamics, blood supply and prognosis of PCI after 3 months. Results: Comparison of ventricular function in left and right dominant coronal artery type groups discharged 7- 10 d after PCI, there were differences in left ventricular ejection fraction (LVEF) [(63.03 ± 5.64)% vs (57.67 ± 7.35)%, P=0.012], peak ejection rate (PER) [(3.52 ± 0.66) end-diastolic volume (EDV)/s vs (2.93 ± 0.73) EDV/s, P =0.011], peak filling rate (PFR) [(2.71 ± 0.88) EDV/s vs (2.11 ± 0.45 ) EDV/s, P=0.004], left free-wall regional ejection fraction [(81.94 ± 20.75)% vs (67.25 ± 16.54)%, P = O.032], and right free-wall regional ejection fraction [(57.86 ± 11.77)% vs (67.83 ± 10.38)%, P=0.012], right ventricular ejection fraction (RVEF) [(37.89 ± 3.86)% vs (41.67 ± 4.81)%, P=0.09]. After 3 months,there was difference only in RVEF [(44.60 ± 5.29)% vs (48.00 ± 3.30)%, P=0.043], but no difference in myocardial perfusion of left ventricle (P=0.357). Conclusions: In acute stage of AIMI right dominant group, there was more severe injury of right ventricle, in convalescent stage most of the right ventricular function resumed. The sustained right ventricular function in part of the patients can be demonstrated by ERNA

  12. Activity and practice of nuclear cardiology in the Czech Republic, 2001

    International Nuclear Information System (INIS)

    Radionuclide myocardial perfusion imaging (MPI) has been on the rise in Europe and the USA. Details on nuclear cardiology in the Czech Republic are not available as yet, as it is impossible to obtain comprehensive data from official registers owing to different methods of reporting and data evaluation. A questionnaire concerning nuclear cardiology activity and practice in 2001 was sent to all nuclear medicine departments in the Czech Republic. All 48 departments completed the questionnaire. In 2001, 50 planar and 54 tomographic (SPET) scintillation cameras were used. The average age of the SPET cameras was 5 years (13% of SPET cameras were >8 years old). Out of the 48 centres, 39 (81%) provided a nuclear cardiology service; the total number of cardiological studies was 15,740 in 2001 (1.5 studies/1,000 population/year). The most frequently employed method was MPI (81.7%), the frequency of which had increased by 10% compared with 2000; 26 of the 39 (67%) departments reported that MPI activity was increasing. Nevertheless, the Czech Republic nuclear cardiology activity remained below the European average (2.2/1,000 population in 1994) and, particularly, below activity in the USA (15/1,000 in 1997). The activity was rather unevenly spread. Whereas two centres with >1,000 studies/year accounted for 20% of the total MPI studies, 16 of 39 (41%) departments exhibited low activity (99mTc-MIBI (60% of total MPI), followed by 201Tl (21%) and 99mTc-tetrofosmin (19%). ECG-gated SPET was employed by 20/39 (51%) centres, of which 11 (28%) performed it as a standard examination; 39% of the total MPI studies included this technique. Thirteen percent (5/39) of the departments used attenuation correction, and 69% (27/39) of the departments used a prone projection. Equilibrium radionuclide ventriculography, with 2,317 examinations (14.7%), ranked second among all nuclear cardiology methods, followed by first-pass angiocardiography (406 studies, 2.6%) and 18F-FDG (163 studies, 1

  13. 彩色多普勒超声心动图在老年动脉导管未闭封堵术中的价值%The value of color Doppler echocardiography in the elderly during the procedure of patent ductus arteriosus occlusion

    Institute of Scientific and Technical Information of China (English)

    侯传举; 朱鲜阳; 张端珍; 王琦光; 邓东安; 韩秀敏

    2012-01-01

    目的 探讨彩色多普勒超声心动图(CDE)在老年动脉导管未闭(PDA)封堵术中的价值.方法 封堵术前应用CDE筛选25例老年PDA适应证,彩色多普勒血流显像(CDFI)分流束血流信号估测PDA肺动脉端直径,与心血管造影对照,经统计学相关处理判断其正确性;连续波多普勒(CW)测量三尖瓣最大反流速度峰值,根据简化伯努利方程△P=4V2估算跨三尖瓣压力阶差,再加上右心房固有压力估测肺动脉压力,与心导管对照,经统计学相关处理判断其正确性;所有患者均行封堵术介入治疗,封堵术后再应用CDE判断封堵术疗效.结果 根据CDE特征筛选25例老年PDA实施封堵术全部获得成功,封堵术后CDE判断疗效满意.CDFI测量分流束血流信号估测PDA肺动脉端直径与心血管造影对照,呈正相关(r =0.71,P<0.001);CW估测肺动脉压力与心导管对照,呈正相关(r=0.63,P<0.001).结论 CDE在老年PDA封堵术中具有重要价值,封堵术前筛选适应证应用CDFI估测PDA肺动脉端直径和应用CW估测肺动脉压力是关键,封堵术后判断疗效应用CDFI观察有无过PDA残余分流很重要.%Objective To investigate the value of color Doppler echocardiography (CDE) in the closure of patent ductus arteriosus (PDA) in the elderly. Methods Before the occlusion, the indicantions for twenty-five elderly patients with PDA were screened by CDE. Using the shunt flow signal of color Doppler flow imaging (CDFI) , we estimated the pulmonary side diameter of PDA and compared with the angiocardiography and determined its accuracy through statistics. Using the continuous wave Doppler (CW), we measured peak velocity of tricuspid regurgitation and estimated crosstricuspid pressure gradient according to the simplified Bernoulli equation △P = 4V2 , together with the inherent right atrial pressure to estimate pulmonary artery pressure. Then, we compared cross-trtcuspid pressure gradient and pulmonary artery pressure

  14. Visualization techniques for multislice CT datasets of coronary arteries: correlation of axial, multiplanar, three-dimensional, and virtual endoscopic imaging with coronary angiography; Visualisierungsmodalitaeten in der Multidetektor CT-Koronarangiographie des Herzens: Korrelation von axialer, multiplanarer, dreidimensionaler und virtuell endoskopischer Bildgebung mit der invasiven Diagnostik

    Energy Technology Data Exchange (ETDEWEB)

    Herzog, C.; Ay, M.; Engelmann, K.; Abolmaali, N.; Diebold, T.; Vogl, T.J. [Frankfurt Univ. (Germany). Inst. fuer Diagnostische und Interventionelle Radiologie; Dogani, S. [Frankfurt Univ. (Germany). Klinik fuer Thorax-, Herz- und Gefaesschirurgie

    2001-04-01

    Objective: To evaluate the performance of 4 different visualization techniques for multislice CT datasets from the coronary arteries in comparison to coronary angiography. Material and Methods: 42 patients were examined prospectively using both multislice CT and angiocardiography. All CT scans were performed at collimation 4x1 mm, pitch 1.5 and a rotation time of 500 msec. Using retrospective ecg-gating, image reconstruction parameters were 1.25 mm slice thickness, 0.5 mm increment and kernel B 30. Each patient's CT dataset subsequently was explored using axial, multiplanar, three-dimensional, and virtual endoscopic visualization modes. Results: Axial scans showed the highest sensitivity in the evaluation of stenoses (66.7%), followed by virtual endoscopy (55.9%), multiplanar (48.6%), and three-dimensional reformations (33.3%). With regard to the detection of atherosclerotic plaques, axial scans (71.2%), three-dimensional reformations (70.1%), and virtual endoscopy (69.1%) displayed comparable sensitivities, whereas multiplanar reformations showed distinctly lower results (55.6%). On combining the techniques a sensitivity of 74.2% for the detection of atherosclerotic plaques, of 72.0% for the identification of high-grade stenoses, respectively, was obtained. The specificity of all four visualization modes amounted to 91.9% and above. Best results have been obtained within the RIVA (sensitivity 85.2%). (orig.) [German] Ziel: Evaluierung der Wertigkeit verschiedener Bildgebungsmodalitaeten der Multidetektor CT-Koronarographie in Korrelation mit der invasiven kardiologischen Diagnostik. Material und Methoden: Im Rahmen einer prospektiven Studie wurden 42 Patienten vergleichend mittels Multidetektor-CT und Herzkatheter untersucht. Das standardisierte Protokoll sah eine Kollimation von 4x1 mm bei einem Tischvorschub von 1,5 mm/Umdrehung und einer Rotationszeit von 500 ms vor. Die anschliessende Bildreformation erfolgte mittels retrospektivem EKG-Gating bei einer