Identification of 253Md

International Nuclear Information System (INIS)

Kadkhodayan, B.; Czerwinski, K.R.; Kreek, S.A.; Hannink, N.J.; Gregorich, K.E.; Lee, D.M.; Nurmia, M.J.; Hoffman, D.C.; Hall, H.L.

1992-01-01

We have measured the half-life and production cross section of the new isotope 253 Md, produced via the 243 Am( 13 C,3n) reaction. Isolation of Md from other activities was accomplished using elution with ammonium α-hydroxyisobutyrate from a cation exchange resin column. Experiments were performed with different irradiation time intervals, but the chemical separation always began and ended at exactly the same length of time after the end of irradiation. All separations with the same irradation lengths were combined and analyzed for growth and decay of the 3.0-d 253 Fm daughter and 20.47-d 253 Es, granddaugther of 253 Md. The amount of 253 Es in each fraction depends on the length of each irradiation and the 253 Md half-life. An increase in the length of irradiation will cause a corresponding increase in the amount of the new isotope 253 Md and hence, in the amount of 253 Es produced, provided the length of irradiations are not very long compared to the half-life of 253 Md. In this way, the Md half-life was estimated to be about 6 minutes with a production cross section of the order of 50 nb. (orig.)

Angels or demons? You decide!

CERN Multimedia

2009-01-01

The new film Angels & Demons starring Tom Hanks and directed by Ron Howard is being premiered worldwide on 15 May, but you could see it 10 days earlier at a special preview screening as the CERN Press Office has a limited number of tickets to give away. Preview of the new CERN website to be published on 5 May. Opinion is split among CERNois when talking about Dan Brown’s book Angels & Demons. Should he be praised for bringing particle physics into the spotlight or should he be demonised for the ‘creative liberties’ he took - for example, although it would be useful for the international collaborations, CERN doesn’t actually have its own private airport and supersonic jet. But love it or hate it, with the upcoming release of the multi-million dollar Hollywood film adaptation, Angels & Demons will introduce a huge new audience to CERN. "Guess what? – CERN really exists!" said...

75 FR 3981 - National Angel Island Day, 2010

Science.gov (United States)

2010-01-26

...--from Chinese, Japanese, and Korean to Russian, German, and Urdu. These etchings remain on Angel Island... learn more about the history of Angel Island and to observe this anniversary with appropriate ceremonies...

Conceptions of warlike angels in literature of the late Second Temple period

OpenAIRE

Michalak, Aleksander Roman

2011-01-01

The work begins with a chapter that presents the various traditions concerning "angelic" warriors in the Hebrew Bible. In this context, we have investigated the two main biblical traditions: the council of gods and the Angel of Yahweh. It can be demonstrated that both these traditions were connected with martiality, which might have influenced later speculations about warlike angels. The second chapter deals with the various Second Temple beliefs concerning the principal angels, angelic hiera...

Trouble Brewing in Los Angeles. Policy Brief

Science.gov (United States)

Buck, Stuart

2010-01-01

The city of Los Angeles will face enormous budgetary pressures from the growing deficits in public pensions, both at a state and local level. In this policy brief, the author estimates that Los Angeles faces a total $152.6 billion liability for pensions that are underfunded--including $49.1 billion for the city pension systems, $2.4 billion for…

The Charismatic Entrepreneur - Personal behaviors in entrepreneurs for attracting angel investment

OpenAIRE

Roaldsnes, Tomas

2017-01-01

Does the entrepreneur’s personal behavior play a major role when attracting angel investment? To answer this question, the opinions and experiences of two angel investors, a business developer for an angel investor network and a successful entrepreneur are gathered and analyzed. The thesis builds on theories from leadership, behavioral psychology and studies on angel investment to give the reader an understanding of the different personal behaviors and their effect. The findings indicate that...

Apple (Malus domestica) MdERF2 negatively affects ethylene biosynthesis during fruit ripening by suppressing MdACS1 transcription.

Science.gov (United States)

Li, Tong; Jiang, Zhongyu; Zhang, Lichao; Tan, Dongmei; Wei, Yun; Yuan, Hui; Li, Tianlai; Wang, Aide

2016-12-01

Ripening in climacteric fruit requires the gaseous phytohormone ethylene. Although ethylene signaling has been well studied, knowledge of the transcriptional regulation of ethylene biosynthesis is still limited. Here we show that an apple (Malus domestica) ethylene response factor, MdERF2, negatively affects ethylene biosynthesis and fruit ripening by suppressing the transcription of MdACS1, a gene that is critical for biosynthesis of ripening-related ethylene. Expression of MdERF2 was suppressed by ethylene during ripening of apple fruit, and we observed that MdERF2 bound to the promoter of MdACS1 and directly suppressed its transcription. Moreover, MdERF2 suppressed the activity of the promoter of MdERF3, a transcription factor that we found to bind to the MdACS1 promoter, thereby increasing MdACS1 transcription. We determined that the MdERF2 and MdERF3 proteins directly interact, and this interaction suppresses the binding of MdERF3 to the MdACS1 promoter. Moreover, apple fruit with transiently downregulated MdERF2 expression showed higher ethylene production and faster ripening. Our results indicate that MdERF2 negatively affects ethylene biosynthesis and fruit ripening in apple by suppressing the transcription of MdACS1 via multiple mechanisms, thereby acting as an antagonist of positive ripening regulators. Our findings offer a deep understanding of the transcriptional regulation of ethylene biosynthesis during climacteric fruit ripening. © 2016 The Authors The Plant Journal © 2016 John Wiley & Sons Ltd.

Business Angels - A Subspecies of the homo oeconomicus ludens.

Science.gov (United States)

Hüsler, Laurenz; Platzer, Erich M

2014-12-01

Business Angels invest in start-up companies in their early stage. This type of investor usually has a good knowledge of the start-up's industry sector, and in addition to the funds he invests, his management experience and his network can be useful for start-ups. Business Angel involvement has shown to improve the success rate and the profitability of start-ups. The article depicts the relationship between entrepreneurs and Business Angels in four case examples.

Angels and Demons in the Book of Jubilees

NARCIS (Netherlands)

Ruiten, Jacques van; Reiterer, F.V.; Nicklas, T.; Schöpflin, K.

2007-01-01

Jacques van Ruiten, “Angels and Demons in the Book of Jubilees,” in Angels: The Concept of Celestial Beings – Origins, Development and Reception (ed. Friedrich V. Reiterer, Tobias Nicklas, and Karin Schöpflin; Deuterocanonical and Cognate Literature Yearbook 2007; Berlin and New York: de Gruyter,

40 CFR 81.17 - Metropolitan Los Angeles Air Quality Control Region.

Science.gov (United States)

2010-07-01

... Quality Control Regions § 81.17 Metropolitan Los Angeles Air Quality Control Region. The Metropolitan Los Angeles Air Quality Control Region consists of the following territorial area (including the territorial... 40 Protection of Environment 17 2010-07-01 2010-07-01 false Metropolitan Los Angeles Air Quality...

Should government support business angel networks? The tale of Danish business angels network

DEFF Research Database (Denmark)

Christensen, Jesper Lindgaard

2011-01-01

. This article discusses the possible rationale for governments to support BANs and what criteria to apply when evaluating such networks. The article is based on an in-depth observation study of the whole life cycle of a national BAN – the Danish Business Angel Network (DBAN) – and a comparison with a similar......Policies promoting informal venture capital generally and business angel networks (BANs) in particular have gained increased attention in recent years. As a consequence, BANs are now widespread across Europe. However, there continues to be a debate whether BANs should be supported with public money...... whether to provide continuing support to BANs they should evaluate not only their immediate effectiveness but also whether BANs should be considered a part of the general small business support infrastructure....

Angels and Demons in the Book of Jubilees

OpenAIRE

Ruiten, Jacques van; Reiterer, F.V.; Nicklas, T.; Schöpflin, K.

2007-01-01

Jacques van Ruiten, “Angels and Demons in the Book of Jubilees,” in Angels: The Concept of Celestial Beings – Origins, Development and Reception (ed. Friedrich V. Reiterer, Tobias Nicklas, and Karin Schöpflin; Deuterocanonical and Cognate Literature Yearbook 2007; Berlin and New York: de Gruyter, 2007), 585-609.

Angels or demons?

Science.gov (United States)

2008-06-01

A fringe meeting at this year's RCN congress, 'Angels and demons… dignity at the heart of nursing', debated the issue of the media portrayal of nurses. Nurses are often depicted at polarised ends of the continuum and the event generated ideas and discussion about how nurses can influence the media portrayal of the profession.

75 FR 47203 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-11 and MD-11F Airplanes Equipped...

Science.gov (United States)

2010-08-05

... Airworthiness Directives; McDonnell Douglas Corporation Model MD- 11 and MD-11F Airplanes Equipped With General... Sec. 39.13 by adding the following new AD: 2010-16-03 McDonnell Douglas Corporation: Amendment 39... applies to McDonnell Douglas Corporation Model MD-11 and MD-11F airplanes, certified in any category...

Md-miR156ab and Md-miR395 Target WRKY Transcription Factors to Influence Apple Resistance to Leaf Spot Disease.

Science.gov (United States)

Zhang, Qiulei; Li, Yang; Zhang, Yi; Wu, Chuanbao; Wang, Shengnan; Hao, Li; Wang, Shengyuan; Li, Tianzhong

2017-01-01

MicroRNAs (miRNAs) are key regulators of gene expression that post-transcriptionally regulate transcription factors involved in plant physiological activities. Little is known about the effects of miRNAs in disease resistance in apple ( Malus × domestica ). We globally profiled miRNAs in the apple cultivar Golden Delicious (GD) infected or not with the apple leaf spot fungus Alternaria alternaria f. sp. mali (ALT1), and identified 58 miRNAs that exhibited more than a 2-fold upregulation upon ALT1 infection. We identified a pair of miRNAs that target protein-coding genes involved in the defense response against fungal pathogens; Md-miR156ab targets a novel WRKY transcription factor, MdWRKYN1, which harbors a TIR and a WRKY domain. Md-miR395 targets another transcription factor, MdWRKY26, which contains two WRKY domains. Real-time PCR analysis showed that Md-miR156ab and Md-miR395 levels increased, while MdWRKYN1 and MdWRKY26 expression decreased in ALT1-inoculated GD leaves; furthermore, the overexpression of Md-miR156ab and Md-miR395 resulted in a significant reduction in MdWRKYN1 and MdWRKY26 expression. To investigate whether these miRNAs and their targets play a crucial role in plant defense, we overexpressed MdWRKYN1 or knocked down Md-miR156ab activity, which in both cases enhanced the disease resistance of the plants by upregulating the expression of the WRKY-regulated pathogenesis-related (PR) protein-encoding genes MdPR3-1, MdPR3-2, MdPR4, MdPR5, MdPR10-1 , and MdPR10-2 . In a similar analysis, we overexpressed MdWRKY26 or suppressed Md-miR395 activity, and found that many PR protein-encoding genes were also regulated by MdWRKY26 . In GD, ALT-induced Md-miR156ab and Md-miR395 suppress MdWRKYN1 and MdWRKY26 expression, thereby decreasing the expression of some PR genes, and resulting in susceptibility to ALT1.

75 FR 80744 - Airworthiness Directives; McDonnell Douglas Corporation Model DC-9-81 (MD-81), DC-9-82 (MD-82...

Science.gov (United States)

2010-12-23

...-1203; Directorate Identifier 2010-NM-168-AD] RIN 2120-AA64 Airworthiness Directives; McDonnell Douglas... amends Sec. 39.13 by adding the following new airworthiness directive (AD): McDonnell Douglas Corporation... Douglas Corporation Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD-83), DC-9-87 (MD-87) and MD-88...

The Los Angeles basin

International Nuclear Information System (INIS)

Rintoul, W.

1991-01-01

In the early 1890s, Edward L Doheny, a mining prospector down on his luck, observed residents of Los Angeles gathering brea from the area's tar pits for use as fuel in coal-scarce California. Realizing that this crude tar was petroleum that had congealed upon contact with the open air, Doheny explored the residential neighborhood near Westlake Park, pooled resources with Charles A Canfield, an old mining crony, and purchased a city lot for $400. This paper reports that drilling wells in the Los Angeles City field posed the problem of making oil production compatible with urban living. Residents had to deal with noise, dirt, traffic, odors, and waste disposal. At least one solution to the waste disposal problem proved unique. A homeowner with a rig in his backyard had no place for a sump in which to run waste water and mud. However, his house had a basement, and that's where the mud went

mdFoam+: Advanced molecular dynamics in OpenFOAM

Science.gov (United States)

Longshaw, S. M.; Borg, M. K.; Ramisetti, S. B.; Zhang, J.; Lockerby, D. A.; Emerson, D. R.; Reese, J. M.

2018-03-01

This paper introduces mdFoam+, which is an MPI parallelised molecular dynamics (MD) solver implemented entirely within the OpenFOAM software framework. It is open-source and released under the same GNU General Public License (GPL) as OpenFOAM. The source code is released as a publicly open software repository that includes detailed documentation and tutorial cases. Since mdFoam+ is designed entirely within the OpenFOAM C++ object-oriented framework, it inherits a number of key features. The code is designed for extensibility and flexibility, so it is aimed first and foremost as an MD research tool, in which new models and test cases can be developed and tested rapidly. Implementing mdFoam+ in OpenFOAM also enables easier development of hybrid methods that couple MD with continuum-based solvers. Setting up MD cases follows the standard OpenFOAM format, as mdFoam+ also relies upon the OpenFOAM dictionary-based directory structure. This ensures that useful pre- and post-processing capabilities provided by OpenFOAM remain available even though the fully Lagrangian nature of an MD simulation is not typical of most OpenFOAM applications. Results show that mdFoam+ compares well to another well-known MD code (e.g. LAMMPS) in terms of benchmark problems, although it also has additional functionality that does not exist in other open-source MD codes.

Coca-Cola Hispanic Education Fund: Los Angeles Program Description.

Science.gov (United States)

Coca Cola Bottling Co. of Los Angeles, CA.

The Coca-Cola Hispanic Education Fund was created in response to the high school dropout problem in Los Angeles. The Fund enables the Coca-Cola Bottling Company of Los Angeles to build upon the successful relationship it has developed in the Hispanic community and maximizes the effectiveness of existing student support programs by directing needy…

Avaliação eletroforética, cromatográfica e molecular da Hb D Los Angeles no Brasil Electrophoretical, chromatographic and molecular valuations of Hb D Los Angeles in Brazil

Directory of Open Access Journals (Sweden)

Ana R. Chinelato-Fernandes

2003-01-01

Full Text Available A variante de hemoglobina (Hb D mais comum, Hb D Los Angeles ou D Punjab, é originada de uma transversão GAA->CAA no códon 121 da globina beta; essa mutação resulta na substituição do ácido glutâmico por glutamina na proteína. É a terceira variante de hemoglobina mais freqüente da população brasileira. Como as hemoglobinas D apresentam migração similar à hemoglobina S em pH alcalino, e com a hemoglobina A em pH ácido, são necessários vários testes para o correto diagnóstico. No presente estudo objetivou-se relacionar os diferentes procedimentos laboratoriais de rotina diagnóstica, além da análise molecular, para estabelecer o perfil de Hb D Los Angeles no Brasil. Foram analisados 47 indivíduos da população brasileira com provável Hb D Los Angeles, por vários procedimentos eletroforéticos em diferentes condições de pH, além da cromatografia líquida de alta pressão, e testes moleculares para confirmação da mutação. Foram encontrados quatro tipos de combinações de hemoglobinas: 42 indivíduos portadores de hemoglobina AD Los Angeles, dois indivíduos com doença de Hb S/D Los Angeles, dois indivíduos com Hb D Los Angeles e talassemia beta e um indivíduo com Hb D Los Angeles e Hb Lepore. Os indivíduos heterozigotos para D Los Angeles são assintomáticos, entretanto, em associação com outras variantes e talassemias podem apresentar graus variáveis de manifestações clínicas. Os resultados apresentados enfatizaram a necessidade da associação de várias metodologias para a identificação da Hb D Los Angeles, além de auxiliar na elucidação de combinações raras.The most common Hb D variant, the Hb D-Los Angeles, also know as Hb D-Punjab, originates through a GAA->CAA change at the 121 codon of the beta globin gene; this mutation results in the replacement of glutamic acid for glutamine in the protein. It is the third most common hemoglobin variant in the Brazilian population. This variant has

Preparing MD-PhD students for clinical rotations: navigating the interface between PhD and MD training.

Science.gov (United States)

Goldberg, Charles; Insel, Paul A

2013-06-01

Many aspects of MD-PhD training are not optimally designed to prepare students for their future roles as translational clinician-scientists. The transition between PhD research efforts and clinical rotations is one hurdle that must be overcome. MD-PhD students have deficits in clinical skills compared with those of their MD-only colleagues at the time of this transition. Reimmersion programs (RPs) targeted to MD-PhD students have the potential to help them navigate this transition.The authors draw on their experience creating and implementing an RP that incorporates multiple types of activities (clinical exam review, objective structured clinical examination, and supervised practice in patient care settings) designed to enhance the participants' skills and readiness for clinical efforts. On the basis of this experience, they note that MD-PhD students' time away from the clinical environment negatively affects their clinical skills, causing them to feel underprepared for clinical rotations. The authors argue that participation in an RP can help students feel more comfortable speaking with and examining patients and decrease their anxiety regarding clinical encounters. The authors propose that RPs can have positive outcomes for improving the transition from PhD to clinical MD training in dual-degree programs. Identifying and addressing this and other transitions need to be considered to improve the educational experience of MD-PhD students.

First thoughts on MD priorities for 2012

CERN Document Server

Zimmermann, F; Assmann, R

2012-01-01

In 2012, 22 days of beam time will be allocated for LHC MDs. In this paper, after recalling the 2011 LHC MD experience, the MD rrequests for 2012 are reviewed. Three primary MD themes for 2012 can be identified: 1)pushing performance in 2012, 2)preparing for 2014/15, and 3)towards maximum luminosity. Example topics include emittance growth in collision or enhanced satellites for theme 1), 25 ns operation for 2), and ATS optics for 3). Structures lists of MD requests and topics for each theme as well as some initial thoughts on the MD priorities are presented. For certain topics, "start-of-fill MDs" are proposed in order to most efficiently use of the available beam time.

Professional Identity at Los Angeles College of Chiropractic.

Science.gov (United States)

Kimura, Melissa Nagare; Russell, Robb; Scaringe, John

2016-12-01

The objective of this article is to describe chiropractic professional identity as espoused by the Los Angeles College of Chiropractic. Professional identity is a construct that begins formation prior to career selection, can be considered the backbone of health care education, and has been linked to career success. Los Angeles College of Chiropractic's professional identity is shaped by a philosophy of health care that is focused on vitalism, holism, naturalism, therapeutic conservatism, critical rationalism, phenomenology, humanism, and interprofessionalism. Other distinguishing aspects include portal-of-entry professionals with broad diagnostic skills; a focus on spine care; promotion of public-health; and delivery of manual treatments. The chiropractic professional identity at the Los Angeles College of Chiropractic focuses on serving the needs of the people who entrust their health to its graduates and will continue to evolve on the basis of many factors, such as politics, social perceptions, and economic conditions.

Cancer risk among Los Angeles women with cosmetic breast implants.

Science.gov (United States)

Deapen, Dennis M; Hirsch, Elliot M; Brody, Garry S

2007-06-01

As the first generation of women who received cosmetic breast implants ages, questions remain about cancer risk. This study is an update of the Los Angeles Augmentation Mammaplasty Study and examines cancer risk among women with long-term exposure to breast implants. The authors conducted a record linkage cohort study of patients with cosmetic breast implants by abstracting from records of the private practices of 35 board-certified plastic surgeons in Los Angeles County, California. They included 3139 Caucasian women who received cosmetic breast implants between 1953 and 1980. Spanish-surnamed women, nonresidents of Los Angeles County, and patients with prior subcutaneous mastectomy or breast cancer were excluded. Cancer outcomes through 1994 were ascertained through record linkage with the Los Angeles County Cancer Surveillance Program. With a mean follow-up period of 15.5 years, 43 cases of breast cancer were observed, compared with 62.6 expected, based on Los Angeles County population-based incidence rates (standardized incidence ratio, 0.69; 95% CI, 0.50 to 0.93). Significant increases were observed for cancer of the lung and bronchus (standardized incidence ratio, 2.14; 95% CI, 1.42 to 3.09) and vulvar cancer (standardized incidence ratio, 3.47; 95% CI, 1.39 to 7.16). The breast cancer results of this study are consistent with the previous reports of the Los Angeles study as well as with several other long-term cohort studies. Lung cancer has previously been found to be increased in this cohort and also in some, but not most, other studies. The increased risk of vulva cancer has previously been observed in this cohort and just one other.

Million trees Los Angeles canopy cover and benefit assessment

Science.gov (United States)

E.G. McPherson; J.R. Simpson; Q. Xiao; C. Wu

2011-01-01

The Million Trees LA initiative intends to improve Los Angeles’s environment through planting and stewardship of 1 million trees. The purpose of this study was to measure Los Angeles’s existing tree canopy cover (TCC), determine if space exists for 1 million additional trees, and estimate future benefits from the planting. High-resolution QuickBird remote sensing data...

Tohoku Women's Hurdling Project: Science Angels (abstract)

Science.gov (United States)

Mizuki, Kotoe; Watanabe, Mayuko

2009-04-01

Tohoku University was the first National University to admit three women students in Japan in 1913. To support the university's traditional ``open-door'' policy, various projects have been promoted throughout the university since its foundation. A government plan, the Third-Stage Basic Plan for Science and Technology, aims to increase the women scientist ratio up to 25% nationwide. In order to achieve this goal, the Tohoku Women's Hurdling Project, funded by the Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT), was adopted in 2006. This project is threefold: support for child/family, improvement of facilities, and support for the next generation, which includes our Science Angels program. ``Science Angels'' are women PhD students appointed by the university president, with the mission to form a strong support system among each other and to become role-models to inspire younger students who want to become researchers. Currently, 50 women graduate students of the natural sciences are Science Angels and are encouraged to design and deliver lectures in their areas of specialty at their alma maters. Up to now, 12 lectures have been delivered and science events for children in our community have been held-all with great success.

Spontaneous fission of 259Md

International Nuclear Information System (INIS)

Hulet, E.K.; Wild, J.F.; Lougheed, R.W.; Baisden, P.A.; Landrum, J.H.; Dougan, R.J.; Mustafa, M.; Ghiorso, A.; Nitschke, J.M.

1979-01-01

The mass and kinetic energy distributions of fission fragments from the spontaneous fission of th newly discovered nuclide 259 Md were obtained. 259 Md was identified as the E. C. daughter of 259 No, and was found to decay entirely (> 95%) by spontaneous fission with a 95-min half-life. From the kinetic energies measured for 397 pairs of coincident fragments, a mass distribution was derived that is symmetric with sigma = 13 amu. 259 Md, together with 258 Fm and 259 Fm, form a select group of three nuclides whose mass division in spontaneous fission is highly symmetric. Unlike the total-kinetic-energy (TKE) distributions of 258 Fm and 259 Fm, which peak at approx. = to 240 MeV, this distribution for 259 Md is broad and is 50 MeV lower in energy. Analysis of the mass and energy distributions shows that events near mass symmetry also exhibit a broad TKE distribution, with one-third of the symmetric events having TKEs less than 200 MeV. The associated of low TKEs with symmetric mass division in the fission of very heavy actinides is anomalous and inconsistent with theories based upon the emergence of fragment shells near the scission point. Either three-body fragmentation or peculiar fragment shapes are assumed as the cause for the large consumption of Coulomb energy observed for a significant fraction of symmetric fissions in 259 Md. 6 figures

Los Angeles Area Permit Holder Estimated Trash Load Reduction, Los Angeles CA, 2012, US EPA Region 9

Data.gov (United States)

U.S. Environmental Protection Agency — The Los Angeles River has been designated as an impaired waterbody due to the large volume of trash it receives from the watershed. To address this problem a Total...

MdMYB9 and MdMYB11 are involved in the regulation of the JA-induced biosynthesis of anthocyanin and proanthocyanidin in apples.

Science.gov (United States)

An, Xiu-Hong; Tian, Yi; Chen, Ke-Qin; Liu, Xiao-Juan; Liu, Dan-Dan; Xie, Xing-Bin; Cheng, Cun-Gang; Cong, Pei-Hua; Hao, Yu-Jin

2015-04-01

Anthocyanin and proanthocyanidin (PA) are important secondary metabolites and beneficial to human health. Their biosynthesis is induced by jasmonate (JA) treatment and regulated by MYB transcription factors (TFs). However, which and how MYB TFs regulate this process is largely unknown in apple. In this study, MdMYB9 and MdMYB11 which were induced by methyl jasmonate (MeJA) were functionally characterized. Overexpression of MdMYB9 or MdMYB11 promoted not only anthocyanin but also PA accumulation in apple calluses, and the accumulation was further enhanced by MeJA. Subsequently, yeast two-hybrid, pull-down and bimolecular fluorescence complementation assays showed that both MYB proteins interact with MdbHLH3. Moreover, Jasmonate ZIM-domain (MdJAZ) proteins interact with MdbHLH3. Furthermore, chromatin immunoprecipitation-quantitative PCR and yeast one-hybrid assays demonstrated that both MdMYB9 and MdMYB11 bind to the promoters of ANS, ANR and LAR, whereas MdbHLH3 is recruited to the promoters of MdMYB9 and MdMYB11 and regulates their transcription. In addition, transient expression assays indicated that overexpression of MdJAZ2 inhibits the recruitment of MdbHLH3 to the promoters of MdMYB9 and MdMYB11. Our findings provide new insight into the mechanism of how MeJA regulates anthocyanin and PA accumulation in apple. © The Author 2014. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Muscular Dystrophy (MD)

Science.gov (United States)

... patients may need assisted ventilation to treat respiratory muscle weakness and a pacemaker for cardiac abnormalities. View Full Treatment Information Definition The muscular dystrophies (MD) are a group of more than 30 ...

Assessing urban forest effects and values, Los Angeles' urban forest

Science.gov (United States)

David J. Nowak; Robert E. III Hoehn; Daniel E. Crane; Lorraine Weller; Antonio. Davila

2011-01-01

An analysis of trees in Los Angeles, CA, reveals that this area has about 6 million trees with tree and shrub canopies that cover 24.9 percent of the city. The most common tree species are Italian cypress, scrub oak, laurel sumac, Mexican fan palm, and Indian laurel, Trees in Los Angeles currently store about 1.3 million tons of carbon (4.7 million tons CO2...

ProtoMD: A prototyping toolkit for multiscale molecular dynamics

Science.gov (United States)

Somogyi, Endre; Mansour, Andrew Abi; Ortoleva, Peter J.

2016-05-01

ProtoMD is a toolkit that facilitates the development of algorithms for multiscale molecular dynamics (MD) simulations. It is designed for multiscale methods which capture the dynamic transfer of information across multiple spatial scales, such as the atomic to the mesoscopic scale, via coevolving microscopic and coarse-grained (CG) variables. ProtoMD can be also be used to calibrate parameters needed in traditional CG-MD methods. The toolkit integrates 'GROMACS wrapper' to initiate MD simulations, and 'MDAnalysis' to analyze and manipulate trajectory files. It facilitates experimentation with a spectrum of coarse-grained variables, prototyping rare events (such as chemical reactions), or simulating nanocharacterization experiments such as terahertz spectroscopy, AFM, nanopore, and time-of-flight mass spectroscopy. ProtoMD is written in python and is freely available under the GNU General Public License from github.com/CTCNano/proto_md.

Harvesting graphics power for MD simulations

NARCIS (Netherlands)

van Meel, J.A.; Arnold, A.; Frenkel, D.; Portegies Zwart, S.F.; Belleman, R.G.

2008-01-01

We discuss an implementation of molecular dynamics (MD) simulations on a graphic processing unit (GPU) in the NVIDIA CUDA language. We tested our code on a modern GPU, the NVIDIA GeForce 8800 GTX. Results for two MD algorithms suitable for short-ranged and long-ranged interactions, and a

Harvesting graphics power for MD simulations

NARCIS (Netherlands)

Meel, J.A. van; Arnold, A.; Frenkel, D.; Portegies Zwart, S.F.; Belleman, R.G.

We discuss an implementation of molecular dynamics (MD) simulations on a graphic processing unit (GPU) in the NVIDIA CUDA language. We tested our code on a modern GPU, the NVIDIA GeForce 8800 GTX. Results for two MD algorithms suitable for short-ranged and long-ranged interactions, and a

Enhancement of Pork Jerky Using Co-cultures of Lactobacillus bulgaricus and Angel Yeast.

Science.gov (United States)

Zhao, Changqing; Lu, Ziyang; Huang, Jing; He, Sha; Tan, Hui; Wang, Gang; Liu, Dayu; Li, Yubin

2016-09-01

Strains of Lactobacillus bulgaricus and Angel Yeast were combined to ferment raw pork and make pork jerky. After fermentation, the jerky was dried and then tested for sensory evaluation, pH and free amino acid content. The results showed that the optimal conditions for fermentation using L. bulgaricus and Angel Yeast were: a pH of 6.5, a 1:1 (v/v) ratio of L. bulgaricus to Angel Yeast, a fermentation time of 42 h and temperature of 25 °C. The results showed that the pork jerky fermented with the combined strains was not very sour which was close to the pH of 7.0 and had a higher free amino acid content which was more than 68.3 mg/100 g compared with the pork jerky fermented by either L. bulgaricus or Angel Yeast alone. Overall, the results demonstrate that fermentation of raw pork with combined strains of L. bulgaricus and Angel Yeast improves the quality and flavor of pork jerky.

Dante o anjeloch (Dante on Angels

Directory of Open Access Journals (Sweden)

Jozef Žilinek

2007-03-01

Full Text Available Dante’s eternal Love was Bice Portinari who died in 1290. Dante saw her in Florence in 1274. She was his muse and her death was the reason to write Divine Comedy. We meet her in part of Divine Comedy calledParadise as a guide into Celestial Empire. I have ever been interested in structure of Celestial Empire and mesmerised by Dante. That was the reason to write this paper. I try to re-construct and complete Dante’s interpretation of the hierarchy of Celestial Empire with focusing on angels. Angels are also called Intellects or forms of the Heaven or substances between the Earth and Heaven or blissful Beings. I also try to find out the answer what happened to souls of people who died, especially to souls of innocent children. In memory of Michalka Režnáková (1984-1995.

Hangar con alas, Los Angeles

Directory of Open Access Journals (Sweden)

Editorial, Equipo

1961-04-01

Full Text Available Formando parte de su programa, la TWA ha construido recientemente un hangar para servicio y reparaciones de su flota aérea de naves ordinarias y de aviones de reacción en el aeropuerto internacional de Los Angeles (Estados Unidos. El proyecto de esta obra se encargó a la empresa constructora Holmes & Narver, Inc.

Combining Rosetta with molecular dynamics (MD): A benchmark of the MD-based ensemble protein design.

Science.gov (United States)

Ludwiczak, Jan; Jarmula, Adam; Dunin-Horkawicz, Stanislaw

2018-07-01

Computational protein design is a set of procedures for computing amino acid sequences that will fold into a specified structure. Rosetta Design, a commonly used software for protein design, allows for the effective identification of sequences compatible with a given backbone structure, while molecular dynamics (MD) simulations can thoroughly sample near-native conformations. We benchmarked a procedure in which Rosetta design is started on MD-derived structural ensembles and showed that such a combined approach generates 20-30% more diverse sequences than currently available methods with only a slight increase in computation time. Importantly, the increase in diversity is achieved without a loss in the quality of the designed sequences assessed by their resemblance to natural sequences. We demonstrate that the MD-based procedure is also applicable to de novo design tasks started from backbone structures without any sequence information. In addition, we implemented a protocol that can be used to assess the stability of designed models and to select the best candidates for experimental validation. In sum our results demonstrate that the MD ensemble-based flexible backbone design can be a viable method for protein design, especially for tasks that require a large pool of diverse sequences. Copyright © 2018 Elsevier Inc. All rights reserved.

A Rapid and Revolutionary Response to the Needs of Wounded Warriors

Science.gov (United States)

2011-10-01

Day, Los Angeles, CA. December 4, 2003 A62 Wilkins, JN, M.D., Kuo, J., M.D., Stewart, S., M.D., Zakari, H., M.D. : Online Videogames : Risks and...Louis, Mo., February, 2005. A64 Videogames and Virtual Reality in Mental Health: An Evidence-Based Review of Cybertherapy Presented at the American

Los Angeles-Long Beach Harbor Areas Cultural Resource Survey, Los Angeles County, California,

Science.gov (United States)

1978-04-01

into nettles and stung by red ants while the adult the Panes or White-heded Eagle Maiden. hunters danced to deerbone flute music. Intriguing sand... combat excepting those in the Philippine Islands (Fort Mills, Fort Hughes, Fort Drum and Fort Frank). It was during the World War II conflict, the...Junior Pest President, Californ a History and Landmarks Club of Los Angeles, Inglewod, February, 1941). Statoments of Mr. Ralph Bandinl, Palo Verdes. Mrs

MD2190: Q" Stabilization during injection

CERN Document Server

Schenk, Michael; Li, Kevin Shing Bruce; Malina, Lukas; Metral, Elias; Tomas Garcia, Rogelio; CERN. Geneva. ATS Department

2018-01-01

This MD is a follow-up study of MD1831, where single bunches were stabilized against impedance-driven instabilities at 6.5 TeV in the LHC with Q''. The goals are (i) to explore whether an amplitude detuning free Q'' knob can be implemented at injection energy, and (ii) whether Q'' can provide beam stability at injection, where the beams suffer mostly from electron cloud effects. Ideally, this would relax the use of the Landau octupoles and may help in preserving the beam quality by reducing dynamic aperture limitations originating from the octupoles. The MD has been split into two parts: First, optics corrections were put in place to minimize beta-beating and linear coupling introduced by the knobs. The corrections were achieved by means of orbit bumps and skew quadrupole knobs. Machine safety was then validated with loss maps. While the betatron loss maps were approved, the off-momentum maps showed a priori unexpected losses in several arcs and the MD was stopped at this point for reasons of machine protecti...

The small ubiquitin-like modifier E3 ligase MdSIZ1 promotes anthocyanin accumulation by sumoylating MdMYB1 under low-temperature conditions in apple.

Science.gov (United States)

Zhou, Li-Jie; Li, Yuan-Yuan; Zhang, Rui-Fen; Zhang, Chun-Ling; Xie, Xing-Bin; Zhao, Cheng; Hao, Yu-Jin

2017-10-01

MdMYB1 acts as a crucial component of the MYB-bHLH-WD40 complex to regulate anthocyanin biosynthesis in red-skinned apples (Malus domestica), but little is known about its post-translational regulation. Here, a small ubiquitin-like modifier E3 ligase MdSIZ1 was screened out as an MdMYB1-interacting protein with a yeast two-hybridization approach. The interaction between MdSIZ1 and MdMYB1 was further verified with pull-down and CoIP assays. Furthermore, it was found that MdSIZ1 directly sumoylated MdMYB1 proteins in vivo and in vitro, especially under moderately low temperature (17 °C) conditions, and that this sumoylation was required for MdMYB1 protein stability. Moreover, the transcription level of MdSIZ1 gene was remarkably induced by low temperature and phosphorus deficiency, and MdSIZ1 overexpression exerted a large positive influence on anthocyanin accumulation and red fruit coloration, suggesting its important role in the regulation of anthocyanin biosynthesis under stress conditions. Our findings reveal an important role for a small ubiquitin-like modifier modification of MYB transcription factors in regulation of anthocyanin biosynthesis in plants. © 2017 John Wiley & Sons Ltd.

El Proyecto Sismico "LARSE" - Trabajando Hacia un Futuro con Mas Seguridad para Los Angeles

Science.gov (United States)

Henyey, Thomas L.; Fuis, Gary S.; Benthien, Mark L.; Burdette, Thomas R.; Christofferson, Shari A.; Clayton, Robert W.; Criley, Edward E.; Davis, Paul M.; Hendley, James W.; Kohler, Monica D.; Lutter, William J.; McRaney, John K.; Murphy, Janice M.; Okaya, David A.; Ryberg, Trond; Simila, Gerald W.; Stauffer, Peter H.

1999-01-01

La region de Los Angeles contiene una red de fallas activas, incluyendo muchas fallas por empuje que son profundas y no rompen la superficie de la tierra. Estas fallas ocultas incluyen la falla anteriormente desconocida que fue responsable por la devastacion que ocurrio durante el terremoto de Northridge en enero de 1994, el terremoto mas costoso en la historia de los Estados Unidos. El Experimento Sismico en la Region de Los Angeles (Los Angeles Region Seismic Experiment, LARSE), esta localizando los peligros ocultos de los terremotos debajo de la region de Los Angeles para mejorar la construccion de las estructuras que pueden apoyar terremotos que son inevitables en el futuro, y que ayudaran a los cientificos determinar donde occurira el sacudimento mas fuerte y poderoso.

MdCOP1 Ubiquitin E3 Ligases Interact with MdMYB1 to Regulate Light-Induced Anthocyanin Biosynthesis and Red Fruit Coloration in Apple1[W][OA

Science.gov (United States)

Li, Yuan-Yuan; Mao, Ke; Zhao, Cheng; Zhao, Xian-Yan; Zhang, Hua-Lei; Shu, Huai-Rui; Hao, Yu-Jin

2012-01-01

MdMYB1 is a crucial regulator of light-induced anthocyanin biosynthesis and fruit coloration in apple (Malus domestica). In this study, it was found that MdMYB1 protein accumulated in the light but degraded via a ubiquitin-dependent pathway in the dark. Subsequently, the MdCOP1-1 and MdCOP1-2 genes were isolated from apple fruit peel and were functionally characterized in the Arabidopsis (Arabidopsis thaliana) cop1-4 mutant. Yeast (Saccharomyces cerevisiae) two-hybrid, bimolecular fluorescence complementation, and coimmunoprecipitation assays showed that MdMYB1 interacts with the MdCOP1 proteins. Furthermore, in vitro and in vivo experiments indicated that MdCOP1s are necessary for the ubiquitination and degradation of MdMYB1 protein in the dark and are therefore involved in the light-controlled stability of the MdMYB1 protein. Finally, a viral vector-based transformation approach demonstrated that MdCOP1s negatively regulate the peel coloration of apple fruits by modulating the degradation of the MdMYB1 protein. Our findings provide new insight into the mechanism by which light controls anthocyanin accumulation and red fruit coloration in apple and even other plant species. PMID:22855936

Carotenoids of Sea Angels Clione limacina and Paedoclione doliiformis from the Perspective of the Food Chain

Directory of Open Access Journals (Sweden)

Takashi Maoka

2014-03-01

Full Text Available Sea angels, Clione limacina and Paedoclione doliiformis, are small, floating sea slugs belonging to Gastropoda, and their gonads are a bright orange-red color. Sea angels feed exclusively on a small herbivorous sea snail, Limacina helicina. Carotenoids in C. limacina, P. doliiformis, and L. helicina were investigated for comparative biochemical points of view. β-Carotene, zeaxanthin, and diatoxanthin were found to be major carotenoids in L. helicina. L. helicina accumulated dietary algal carotenoids without modification. On the other hand, keto-carotenoids, such as pectenolone, 7,8-didehydroastaxanthin, and adonixanthin were identified as major carotenoids in the sea angels C. limacina and P. doliiformis. Sea angels oxidatively metabolize dietary carotenoids and accumulate them in their gonads. Carotenoids in the gonads of sea angels might protect against oxidative stress and enhance reproduction.

Carotenoids of Sea Angels Clione limacina and Paedoclione doliiformis from the Perspective of the Food Chain

Science.gov (United States)

Maoka, Takashi; Kuwahara, Takashi; Narita, Masanao

2014-01-01

Sea angels, Clione limacina and Paedoclione doliiformis, are small, floating sea slugs belonging to Gastropoda, and their gonads are a bright orange-red color. Sea angels feed exclusively on a small herbivorous sea snail, Limacina helicina. Carotenoids in C. limacina, P. doliiformis, and L. helicina were investigated for comparative biochemical points of view. β-Carotene, zeaxanthin, and diatoxanthin were found to be major carotenoids in L. helicina. L. helicina accumulated dietary algal carotenoids without modification. On the other hand, keto-carotenoids, such as pectenolone, 7,8-didehydroastaxanthin, and adonixanthin were identified as major carotenoids in the sea angels C. limacina and P. doliiformis. Sea angels oxidatively metabolize dietary carotenoids and accumulate them in their gonads. Carotenoids in the gonads of sea angels might protect against oxidative stress and enhance reproduction. PMID:24633249

Los Angeles and Its Influence on Professional and Popular Astronomy - A Hollywood Love Story, by Lewis Chilton, Past President, Optical Shop Director and Historian, Los Angeles Astronomical Society

Science.gov (United States)

Chilton, Lew

2013-01-01

The purpose of this presentation is to show through visualizations how the Los Angeles, California milieu of the early 20th century benefited the advancement of astronomy and captured the public consciousness through popular press accounts of these advancements and of the scientists who made them. The thesis of this presentation purports that a symbiosis developed between astronomers of Los Angeles-area scientific and educational institutions and a local community of interested laypersons, and was the catalyst that sparked future generations to enter the fields of astronomy, the allied sciences, education and technology. This presentation attempts to highlight the importance of continued public outreach by the professional astronomical community, for the ultimate benefit to itself, in Los Angeles and beyond.

AnGel System for the diagnosis of generators in operation; Sistema AnGeL para el diagnostico de generadores en operacion

Energy Technology Data Exchange (ETDEWEB)

De la Torre V, H. Octavio; Ramirez N, J. Tomas; Pascacio de los S, Alberth; Reyes M, Oscar A; Carrillo C, Jaime; Iturbe F, Marlene [Instituto de Investigaciones Electricas, Cuernavaca, Morelos (Mexico); Ponce de Leon V, Eugenio [Comision Federal de Electricidad (Mexico)

2005-07-01

The continuous monitoring of the electrical variables of a generator allows the knowing of the operating status of the main components of the equipment, which is helpful at the time of emitting a diagnosis of the same one. System of diagnosis for generators of operation, denominated AnGel System (acronym of Analysis of Generators in Line). The system was developed by the Management of Electrical equipment of the Instituto de Investigaciones Electricas (IIE) and implemented in the six units of generation of the Manzanillo Thermoelectric Unit. The present article includes a description of the main components and functions. The world-wide tendency in monitoring systems of the fault statistics, were key elements in defining the variable to be monitored: Partial discharges (PD), Shaft current (SC), Neutral current (NC), Tangential Magnetic (TM) flux, Voltages and currents of line (as reference to the operation point). The main processes of deterioration that are intended to be observed with each one of these variables are described with greater thoroughness in the article Sistema AnGel: Aspectos teorico-practicos para el diagnostico de generadores en operacion (AnGel System: Theoretical-practical aspects for the diagnosis of generators in operation), contained in the section of Research Activities in this same issue of the IIE bulletin. [Spanish] La monitorizacion continua de las variables electricas de un generador permite conocer el estado operativo de los principales componentes del equipo, lo que es de ayuda a la hora de emitir un diagnostico del mismo. Sistema de diagnostico para generadores de operacion, denominado Sistema AnGeL (acronimo de Analisis de Generadores en Linea). El sistema fue desarrollado por la Gerencia de Equipos Electricos del IIE e implementado en las seis unidades de generacion del Complejo Termoelectrico Manzanillo. El presente articulo incluye una descripcion de los principales componentes y funciones. La tendencia mundial en sistemas de

"Angels & Demons" - Distinguishing truth from fiction

CERN Multimedia

2005-01-01

Dan Brown's best-selling novel "Angels & Demons" was published in French on 2 March. A web page on CERN's public site is dedicated to separating truth from fiction in this novel. After the extraordinary success of Dan Brown's "Da Vinci Code", one of his earlier novels "Angels & Demons", published in 2000, has now become a best seller and has generated a flood of questions about CERN. This detective story is about a secret society, the Illuminati, who wish to destroy the Vatican with an antimatter bomb stolen from - wait for it - CERN! Inevitably, CERN has been bombarded with calls about the technologies described in the novel that are supposed to be under development in the Laboratory. The Press Office has always explained that, even if the novel appears to be very informative, it is in fact a mixture of fact and fiction. For instance, according to the novel CERN is supposed to own a plane that can cover the distance between Massachusetts in the United States and Switzerland in just over an hour! ...

Shortening and Thickening of Metropolitan Los Angeles Measured and Inferred Using Geodesy

Science.gov (United States)

Argus, D.; Heflin, M.; Donnellan, A.; Webb, F.; Dong, D.; Hurst, K.; Jefferson, D.; Lyzenga, G.; Watkins, M.; Zumberge, J.

1999-01-01

Geodetic measurements using the Global Positioning System and other techniques show north-south shortening near Los Angeles to be fastest across the northern part of the metropolitan area, where an ESE-striking, 5- to 40-km-wide belt lying to the south of San Gabriel Mountains and to the north of downtown and West Los Angeles is shortening at 5 mm/yr.

The AINTEGUMENTA genes, MdANT1 and MdANT2, are associated with the regulation of cell production during fruit growth in apple (Malus × domestica Borkh.).

Science.gov (United States)

Dash, Madhumita; Malladi, Anish

2012-06-25

Fruit growth in apple (Malus × domestica Borkh.) is mediated by cell production and expansion. Genes involved in regulating these processes and thereby fruit growth, are not well characterized. We hypothesized that the apple homolog(s) of AINTEGUMENTA (ANT), an APETALA2-repeat containing transcription factor, regulates cell production during fruit growth in apple. Two ANT genes, MdANT1 and MdANT2, were isolated from apple and their expression was studied during multiple stages of fruit development. MdANT1 and MdANT2 expression was high during early fruit growth coincident with the period of cell production, rapidly declined during exit from cell production, and remained low during the rest of fruit development. The effects of increase in carbohydrate availability during fruit growth were characterized. Increase in carbohydrate availability enhanced fruit growth largely through an increase in cell production. Expression of MdANT1 and MdANT2 increased sharply by up to around 5-fold in response to an increase in carbohydrate availability. Expression of the ANT genes was compared across two apple genotypes, 'Gala' and 'Golden Delicious Smoothee' (GS), which differ in the extent of fruit growth, largely due to differences in cell production. In comparison to 'Gala', the larger fruit-size genotype, GS, displayed higher levels and a longer duration of MdANT1 and MdANT2 expression. Expression of the ANTs and cell cycle genes in the fruit core and cortex tissues isolated using laser capture microdissection was studied. During early fruit growth, expression of the MdANTs was higher within the cortex, the tissue that constitutes the majority of the fruit. Additionally, MdANT1 and MdANT2 expression was positively correlated with that of A- and B-type CYCLINS, B-type CYCLIN-DEPENDENT-KINASES (CDKBs) and MdDEL1. Multiple lines of evidence from this study suggest that MdANT1 and MdANT2 regulate cell production during fruit growth in apple. ANTs may coordinate the expression of

Due Diligence and the Evaluation of Teachers: A Review of the Value-Added Analysis Underlying the Effectiveness Rankings of Los Angeles Unified School District Teachers by the "Los Angeles Times"

Science.gov (United States)

Briggs, Derek; Domingue, Ben

2011-01-01

On August 14, 2010, the "Los Angeles Times" published the results of a statistical analysis of student test data to provide information about elementary schools and teachers in the Los Angeles Unified School District (LAUSD). The analysis, covering the period from 2003 to 2009, was put forward as an evaluation of the effects of schools…

ASSESSING ANGELS IN THE NURSERY: A PILOT STUDY OF CHILDHOOD MEMORIES OF BENEVOLENT CAREGIVING AS PROTECTIVE INFLUENCES.

Science.gov (United States)

Narayan, Angela J; Ippen, Chandra Ghosh; Harris, William W; Lieberman, Alicia F

2017-07-01

This pilot study provides the first empirical test of the concept of "Angels in the Nursery" by examining whether childhood memories of benevolent caregiving experiences protect against heightened levels of psychopathology in high-risk mothers. The study hypothesized that (a) elaborated childhood memories of feeling loved by a caregiver ("angel memories") would moderate adulthood posttraumatic stress disorder (PTSD) symptoms in mothers with childhood maltreatment histories, and (b) spontaneous traumatic intrusions ("ghost memories") would mediate childhood maltreatment and adulthood PTSD symptoms. Participants were 54 mothers (M = 32.79 years, SD = 8.91; 59.2% African American, 13.0% Caucasian, 5.6% Latina, 22.2% biracial/multiracial) who completed standardized assessments of childhood maltreatment and adulthood PTSD symptoms, and a novel instrument, the Angels in the Nursery Interview ("Angels Interview," Van Horn, Lieberman, & Harris, 2008). Results showed that angel memories significantly moderated childhood maltreatment and adulthood PTSD symptoms, consistent with a protective effect. Higher levels of ghost memories during the Angels Interview were significantly associated with more extensive childhood maltreatment, but did not mediate maltreatment and PTSD symptoms. Findings indicate that the Angels Interview can identify pathogenic intrusions rooted in childhood maltreatment and protective factors to promote maternal mental health and buffer the intergenerational transmission of trauma. © 2017 Michigan Association for Infant Mental Health.

Apple MdACS6 Regulates Ethylene Biosynthesis During Fruit Development Involving Ethylene-Responsive Factor.

Science.gov (United States)

Li, Tong; Tan, Dongmei; Liu, Zhi; Jiang, Zhongyu; Wei, Yun; Zhang, Lichao; Li, Xinyue; Yuan, Hui; Wang, Aide

2015-10-01

Ethylene biosynthesis in plants involves different 1-aminocyclopropane-1-carboxylic acid synthase (ACS) genes. The regulation of each ACS gene during fruit development is unclear. Here, we characterized another apple (Malus×domestica) ACS gene, MdACS6. The transcript of MdACS6 was observed not only in fruits but also in other tissues. During fruit development, MdACS6 was initiated at a much earlier stage, whereas MdACS3a and MdACS1 began to be expressed at 35 d before harvest and immediateley after harvest, respectively. Moreover, the enzyme activity of MdACS6 was significantly lower than that of MdACS3a and MdACS1, accounting for the low ethylene biosynthesis in young fruits. Overexpression of MdACS6 (MdACS6-OE) by transient assay in apple showed enhanced ethylene production, and MdACS3a was induced in MdACS6-OE fruits but not in control fruits. In MdACS6 apple fruits silenced by the virus-induced gene silencing (VIGS) system (MdACS6-AN), neither ethylene production nor MdACS3a transcript was detectable. In order to explore the mechanism through which MdACS3a was induced in MdACS6-OE fruits, we investigated the expression of apple ethylene-responsive factor (ERF) genes. The results showed that the expression of MdERF2 was induced in MdACS6-OE fruits and inhibited in MdACS6-AN fruits. Yeast one-hybrid assay showed that MdERF2 protein could bind to the promoter of MdACS3a. Moreover, down-regulation of MdERF2 in apple flesh callus led to a decrease of MdACS3a expression, demonstrating the regulation of MdERF2 on MdACS3a. The mechanism through which MdACS6 regulates the action of MdACS3a was discussed. © The Author 2015. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved. For permissions, please email: journals.permissions@oup.com.

User survey of Nanny Angel Network, a free childcare service for mothers with cancer.

Science.gov (United States)

Cohen, L; Schwartz, N; Guth, A; Kiss, A; Warner, E

2017-08-01

The purpose of the present study was to determine user satisfaction with Nanny Angel Network (nan), a free childcare service for mothers undergoing cancer treatment. All 243 living mothers who had used the nan service were invited by telephone to participate in an online research survey; 197 mothers (81%) consented to participate. The survey, sent by e-mail, consisted of 39 items divided into these categories: demographics, supports, use, satisfaction, and general comments. Of the 197 mothers who consented to receive the e-mailed survey, 104 (53%) completed it. More than 90% of the mothers were very satisfied with the help and support from their Nanny Angel. Many mothers mentioned that the Nanny Angel was most helpful during treatment and medical appointments, with 75% also mentioning that their Nanny Angel helped them to adhere to their scheduled medical appointments. However, 64% felt that they had not received enough visits from their Nanny Angel. Satisfaction with the nan childcare provider was high, but mothers wished the service had been available to them more often. Our study highlights the importance of providing childcare to mothers with inadequate support systems, so as to allow for greater adherence to treatment and medical appointments, and for more time to recover.

An Analysis Of Symbols In Dan Brown’s Novel Angels And Demons

OpenAIRE

Savrizal, Muhammad

2014-01-01

Skripsi ini yang berjudul An Analysis Of Symbols In Dan Brown’s Novel Angels And Demons merupakan sebuah analisis mengenai simbol-simbol dalam novel “Angels and Demons” dan pembagian simbol kedalam bagian-bagian tertentu serta mengidentifikasi makna makna simbol tersebut. Beberapa simbol dalam novel ini merupakan simbol Illuminati yang merupakan bagian dari proses komunikasi yang dilakukan setiap anggota didalam Illuminati untuk sesama anggota. Tujuan penulis menganalisis si...

Industria cinematografica e turismo nell’immaginario collettivo: Los Angeles tra mito e creatività / Film industry and tourism in collective imagination: Los Angeles between myth and creativity

Directory of Open Access Journals (Sweden)

Franca Miani

2016-05-01

Full Text Available Obiettivo del contributo è quello di proporre alcuni spunti di riflessione sul caso della città di celluloide più nota al mondo: Los Angeles. Più in particolare s’intende analizzare la stretta relazione che intercorre tra l’attrattività turistica della metropoli e l’industria cinematografica.  Come ben noto, Los Angeles continua da quasi un secolo a suggestionare l’immaginario collettivo in quanto mecca del cinema e patria di Hollywood, l’industria che ha creato il sogno americano. Tuttavia LA, oggi, è anche una delle prime dieci città mondiali. Rappresenta l’esempio di come l’industria creativa (e il cinema è creatività per definizione sia riuscita a realizzare un sistema economico e d’innovazione tecnologica che funziona come polo di attrazione sia per tutti coloro che intendono sviluppare nuove attività, non possibili in altre parti del mondo, sia per visitatori e turisti attirati da un insieme di fattori emozionali legati alla notorietà dei luoghi del sistema cinematografico e dello spettacolo. Sulla base dell’analisi della letteratura e facendo seguito a esperienze di studio sul campo, il contributo vuole evidenziare la stretta connessione costruita nel corso di più di un secolo tra Hollywood, il luogo, e Hollywood, l’industria, per dimostrare come il luogo di produzione rappresenti una componente unica del prodotto finale, un’autenticazione di qualità soggettive e simboliche in grado di amplificare il valore economico intrinseco e di provocare un’attrazione crescente di attività e persone verso l’area metropolitana di Los Angeles.   This paper discusses Los Angeles as the best-known celluloid city in the world, and focuses particularly on the close relationship between its attractiveness for tourists and the film industry. For almost a century Los Angeles has exerted influence over the collective imagination as the mecca of cinema and home of Hollywood, the industry that created the American dream

MD290: Q4 IP6 Quench Level

CERN Document Server

Bednarek, Mateusz Jakub; Lechner, Anton; CERN. Geneva. ATS Department

2016-01-01

The detailed program proposed for the LHC Machine Development concerning a quench induced by fast losses on the MQY.4L6 quadrupole is presented. The merit of the MD, the necessary modifications of the machine protection systems are presented together with a preliminary analysis of the MD results.

Chosen-Prefix Collisions for MD5 and Applications

NARCIS (Netherlands)

M.M.J. Stevens (Marc); A.K. Lenstra (Arjen); B. de Weger (Benne)

2012-01-01

textabstractWe present a novel, automated way to find differential paths for MD5. Its main application is in the construction of \\emph{chosen-prefix collisions}. We have shown how, at an approximate expected cost of $2^{39}$ calls to the MD5 compression function, for any two chosen

Port Angeles, Washington Tsunami Forecast Grids for MOST Model

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — The Port Angeles, Washington Forecast Model Grids provides bathymetric data strictly for tsunami inundation modeling with the Method of Splitting Tsunami (MOST)...

Los Angeles, California Tsunami Forecast Grids for MOST Model

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — The Los Angeles, California Forecast Model Grids provides bathymetric data strictly for tsunami inundation modeling with the Method of Splitting Tsunami (MOST)...

Los Angeles - Long Beach Harbors, California. Los Angeles Harbor Deepening Project. Final Phase 2. General Design Memorandum.

Science.gov (United States)

1980-01-01

land- marks are the San Pedro Breakwater and Angels Gate Lighthouse, the Termial Island Schoolhouse, and the Municipal Fish Market. Descriptions of...MILES, Chairman Navigation and Ocean Development Commission I, Marty Mercado , Secretary of the Navigation and Ocean Development Commission, do hereby...officials who have authority or responsibility in this area. STAN1&’.~LIMCara NAVIGATION AND OCEAN DEVELOPMENT COIISSION I, Marty Mercado , Secretary

"USA Today": Comparative Analysis with Two National and Two Los Angeles Daily Newspapers. Research Bulletin.

Science.gov (United States)

Ames, Steve; And Others

Sections of the newspaper "USA Today" were compared with corresponding sections of four major newspapers--the "New York Times," the "Wall Street Journal," the "Los Angeles Herald Examiner," and the "Los Angeles Times"--to determine what editorial components made "USA Today" different and…

Assessing the allelotypic effect of two aminocyclopropane carboxylic acid synthase-encoding genes MdACS1 and MdACS3a on fruit ethylene production and softening in Malus

Science.gov (United States)

Dougherty, Laura; Zhu, Yuandi; Xu, Kenong

2016-01-01

Phytohormone ethylene largely determines apple fruit shelf life and storability. Previous studies demonstrated that MdACS1 and MdACS3a, which encode 1-aminocyclopropane-1-carboxylic acid synthases (ACS), are crucial in apple fruit ethylene production. MdACS1 is well-known to be intimately involved in the climacteric ethylene burst in fruit ripening, while MdACS3a has been regarded a main regulator for ethylene production transition from system 1 (during fruit development) to system 2 (during fruit ripening). However, MdACS3a was also shown to have limited roles in initiating the ripening process lately. To better assess their roles, fruit ethylene production and softening were evaluated at five time points during a 20-day post-harvest period in 97 Malus accessions and in 34 progeny from 2 controlled crosses. Allelotyping was accomplished using an existing marker (ACS1) for MdACS1 and two markers (CAPS866 and CAPS870) developed here to specifically detect the two null alleles (ACS3a-G289V and Mdacs3a) of MdACS3a. In total, 952 Malus accessions were allelotyped with the three markers. The major findings included: The effect of MdACS1 was significant on fruit ethylene production and softening while that of MdACS3a was less detectable; allele MdACS1–2 was significantly associated with low ethylene and slow softening; under the same background of the MdACS1 allelotypes, null allele Mdacs3a (not ACS3a-G289V) could confer a significant delay of ethylene peak; alleles MdACS1–2 and Mdacs3a (excluding ACS3a-G289V) were highly enriched in M. domestica and M. hybrid when compared with those in M. sieversii. These findings are of practical implications in developing apples of low and delayed ethylene profiles by utilizing the beneficial alleles MdACS1-2 and Mdacs3a. PMID:27231553

Swiss national MD-PhD-program: an outcome analysis.

Science.gov (United States)

Kuehnle, Katrin; Winkler, David T; Meier-Abt, Peter J

2009-09-19

This study aims at a first evaluation of the outcome of the Swiss national MD-PhD program during the last 16 years. One hundred and twenty six former and current students in the Swiss national MD-PhD program were surveyed via a Web-based questionnaire in September 2007. Twenty-four questions assessed information regarding participant demographics, information on the PhD thesis and publication activity, current positions and research activity, as well as participant's opinions, attitudes and career goals. Eighty questionnaires were received from 126 MD-PhD students and graduates (63.5% response rate). The responders consisted of present students (36%), former graduates (56%), and dropouts (8%). The percentage of women in the program was 23%, and the average duration of the program was 4.2 +/- 1.4 years. Research interests were predominantly in the fields of neuroscience, immunology, molecular biology and cancer research. A considerable portion of the MD-PhD graduates had an excellent publication record stemming from their PhD research work, and 89% were planning to continue a research-orientated career. Over 50% of those MD-PhD graduates completing their thesis before 2002 had already reached an assistant or full professor position at the time of the survey. Nearly all participants considered the MD-PhD training helpful to their career and high quality standards were assigned to the acquired practical and intellectual skills. However, criticism was expressed concerning the general mentoring and the career related mentoring. Moreover, general mentoring and career related mentoring were significantly less well perceived in research groups employing more than seven PhD students at the same time. The MD-PhD students and graduates surveyed were satisfied with their education and most of them continued a research-orientated career. Regarding the overall positive evaluation, this study supports the view that MD-PhD graduates are well qualified for a successful career in

MD-11 PCA - Research flight team photo

Science.gov (United States)

1995-01-01

On Aug. 30, 1995, a the McDonnell Douglas MD-11 transport aircraft landed equipped with a computer-assisted engine control system that has the potential to increase flight safety. In landings at NASA Dryden Flight Research Center, Edwards, California, on August 29 and 30, the aircraft demonstrated software used in the aircraft's flight control computer that essentially landed the MD-11 without a need for the pilot to manipulate the flight controls significantly. In partnership with McDonnell Douglas Aerospace (MDA), with Pratt & Whitney and Honeywell helping to design the software, NASA developed this propulsion-controlled aircraft (PCA) system following a series of incidents in which hydraulic failures resulted in the loss of flight controls. This new system enables a pilot to operate and land the aircraft safely when its normal, hydraulically-activated control surfaces are disabled. This August 29, 1995, photo shows the MD-11 team. Back row, left to right: Tim Dingen, MDA pilot; John Miller, MD-11 Chief pilot (MDA); Wayne Anselmo, MD-11 Flight Test Engineer (MDA); Gordon Fullerton, PCA Project pilot; Bill Burcham, PCA Chief Engineer; Rudey Duran, PCA Controls Engineer (MDA); John Feather, PCA Controls Engineer (MDA); Daryl Townsend, Crew Chief; Henry Hernandez, aircraft mechanic; Bob Baron, PCA Project Manager; Don Hermann, aircraft mechanic; Jerry Cousins, aircraft mechanic; Eric Petersen, PCA Manager (Honeywell); Trindel Maine, PCA Data Engineer; Jeff Kahler, PCA Software Engineer (Honeywell); Steve Goldthorpe, PCA Controls Engineer (MDA). Front row, left to right: Teresa Hass, Senior Project Management Analyst; Hollie Allingham (Aguilera), Senior Project Management Analyst; Taher Zeglum, PCA Data Engineer (MDA); Drew Pappas, PCA Project Manager (MDA); John Burken, PCA Control Engineer.

Angelic and Crepuscular in Alexandru Sever’s Drama

Directory of Open Access Journals (Sweden)

Elena IANCU

2014-12-01

Full Text Available The illustration of a world, apparently drifting, the (demystification of the transcendent and of the act of creation, as idea and textual strategy, seem to Alexandru Sever (1921-2010 a means for another beginning. The impossibility of action in Înger bătrîn/ The Old Angel (1977 and the pact-making in Îngerul slut/ The Miscreated Angel (1982, imply metamorphosis in essence, supported by the dialogue with the great texts of the world, by intertextuality (the biblical text, Shakespeare's texts -Hamlet -Yorick, texts written by Göethe, Beckett, Marlowe, Dostoevsky, J. P. Sartre, Mikhail Bulgakov and others. The projection of Auschwitz, as a Siberia of the spirit, and that of Faustianism, result in a detailed analysis of the human, both as individuality and as community, in an attempt to illustrate the (inintelligible inaction, death involving catharsis in the mundane and the theatre alike.

Aeropuerto internacional de Los Angeles: Edificio "Theme"

Directory of Open Access Journals (Sweden)

Editorial, Equipo

1961-10-01

Full Text Available Recientemente, se ha terminado un nuevo edificio en el aeropuerto de Los Angeles, que constituye una estación aérea, moderna por su forma y servicios de que está dotada, en la que se ha dado cabida a todas las necesidades actuales que el servicio de aeronaves reactores requiere.

75 FR 57857 - Safety Zone; Blue Angels at Kaneohe Bay Air Show, Oahu, HI

Science.gov (United States)

2010-09-23

... DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 165 [Docket No. USCG-2010-0705] RIN 1625-AA00 Safety Zone; Blue Angels at Kaneohe Bay Air Show, Oahu, HI AGENCY: Coast Guard, DHS. ACTION...; Blue Angels at Kaneohe Bay Air Show, Oahu, HI in the Federal Register (75 FR 159). We received no...

UCLA's outreach program of science education in the Los Angeles schools.

Science.gov (United States)

Palacio-Cayetano, J; Kanowith-Klein, S; Stevens, R

1999-04-01

The UCLA School of Medicine's Interactive Multi-media Exercises (IMMEX) Project began its outreach into pre-college education in the Los Angeles area in 1993. The project provides a model in which software and technology are effectively intertwined with teaching, learning, and assessment (of both students' and teachers' performances) in the classroom. The project has evolved into a special collaboration between the medical school and Los Angeles teachers. UCLA faculty and staff work with science teachers and administrators from elementary, middle, and high schools. The program benefits ethnically and racially diverse groups of students in schools ranging from the inner city to the suburbs. The project's primary goal is to use technology to increase students' achievement and interest in science, including medicine, and thus move more students into the medical school pipeline. Evaluations from outside project evaluators (West Ed) as well as from teachers and IMMEX staff show that the project has already had a significant effect on teachers' professional development, classroom practice, and students' achievement in the Los Angeles area.

Intentional, Inadvertent, or Inevitable? James Burrill Angell and Secularization at the University of Michigan.

Science.gov (United States)

Bouman, Jeffrey Paul

The history of James Burrill Angell as the president of the University of Michigan presents a case study of the role of 19th century liberal Protestant university builders in the eventual marginalization of religion from the mainstream of U.S. higher education. Angell's tenure, which began in 1871, encompassed the period in which the modern…

Angels and IPOs: Policies for Sustainable Equity Financing of Irish Small Businesses

OpenAIRE

Mulcahy, Diane

2005-01-01

Angels and IPOs: Policies for Sustainable Equity Financing of Irish Small Businesses explores the rationale for the Irish government?s investments of more than 300 million Euro in Irish companies and the domestic venture capital industry. It challenges the conventional wisdom that there is an `equity gap? of early stage risk capital in Ireland. In the context of the equity financing cycle, it discusses the limited supply of angel capital available to Irish firms as well as the `exit gap? resu...

Modeling smog along the Los Angeles-Palm Springs trajectory

International Nuclear Information System (INIS)

Hanna, S.R.

1976-01-01

Observations of smog concentrations and wind patterns during the summer of 1973 in Los Angeles, Pomona, Riverside, Banning, and Palm Springs, California are presented which show that high oxidant concentrations at Banning and Palm Springs are often due to advection of smog from source regions in the more densely populated western part of the Los Angeles basin. At Pomona and Riverside, advection from upwind source regions combines with the effects of local emissions to cause long durations of high oxidant concentrations with peak times in the mid afternoon. An empirical model for the diurnal oxidant variation is suggested which satisfactorily simulates observed concentrations. More complex models which include chemical kinetics systems do not perform very satisfactorily at the rural stations of Banning and Palm Springs, especially at night when observed oxidant concentrations remain high

A young Russian choir at CERN

CERN Multimedia

CERN Bulletin

2010-01-01

On Thursday 8 April, a Russian choir of 39 children from Gatchina (45 km from St Petersburg) visited CERN and improvised a very nice performance in the Reception of building 33. Marina Savino from PH-UCM was the interpreter.

33 CFR 165.1319 - Safety Zone Regulations, Seafair Blue Angels Air Show Performance, Seattle, WA.

Science.gov (United States)

2010-07-01

... Blue Angels Air Show Performance, Seattle, WA. 165.1319 Section 165.1319 Navigation and Navigable... Thirteenth Coast Guard District § 165.1319 Safety Zone Regulations, Seafair Blue Angels Air Show Performance... Peninsula; thence northerly along the shore of Mercer Island to the point of origin. [Datum: NAD 1983] (c...

CALS Test Network Handbook

Science.gov (United States)

1993-03-01

Ltd Gillette Company Dorset, England Boston MA Foreign Broadcast Information Set. Giordano Associates Inc Frederick MD Long Branch NJ Formtek Inc...Associates Orem UT College Park MD InfoDesign Corp Johns Hopkins University Toronto, Ontario Laurel MD Information Spectrum Inc Joint Committee on Printing...Inc Washington DC Bel Air MD Navy Naval Research Laboratory OutSource Inc Washington DC Los Angeles CA 22 i +’ . S.. . -- -,•w• -- w,,Wmwmm mm -- m mmm

76 FR 5686 - Drawbridge Operation Regulation; Pocomoke River, Pocomoke City, MD

Science.gov (United States)

2011-02-02

... Operation Regulation; Pocomoke River, Pocomoke City, MD AGENCY: Coast Guard, DHS. ACTION: Notice of... River, mile 15.6, at Pocomoke City, MD. The deviation restricts the operation of the draw span to.... The Route 675 Bridge across Pocomoke River, mile 15.6 at Pocomoke City MD, has a vertical clearance in...

76 FR 48898 - Robert Leigh Kale, M.D., Decision and Order

Science.gov (United States)

2011-08-09

... DEPARTMENT OF JUSTICE Drug Enforcement Administration Robert Leigh Kale, M.D., Decision and Order... Enforcement Administration, issued an Order to Show Cause to Robert Leigh Kale, M.D. (Registrant), of Fort... Certificate of Registration, BK9514375, issued to Robert Leigh Kale, M.D., be, and it hereby is, revoked. I...

76 FR 20032 - Thomas E. Mitchell, M.D.; Dismissal of Proceeding

Science.gov (United States)

2011-04-11

... DEPARTMENT OF JUSTICE Drug Enforcement Administration [Docket No. 10-7] Thomas E. Mitchell, M.D... Control, Drug Enforcement Administration, issued an Order to Show Cause to Thomas E. Mitchell, M.D....100(b) and 0.104, I hereby order that the Order to Show Cause issued to Thomas E. Mitchell, M.D., be...

Predicting Los Angeles abrasion loss of rock aggregates from ...

Indian Academy of Sciences (India)

WINTEC

For this reason, to investigate the possibility of predicting the Los Angeles ... Different rocks have extensively been used as an aggregate .... men weight to the specimen volume. .... thesis is rejected and that there is a real relation between.

77 FR 7182 - Scott W. Houghton, M.D.; Decision and Order

Science.gov (United States)

2012-02-10

... DEPARTMENT OF JUSTICE Drug Enforcement Administration [Docket No. 12-09] Scott W. Houghton, M.D... CFR 0.100(b), I order that DEA Certificate of Registration BH8796077, issued to Scott W. Houghton, M.D., be, and it hereby is, revoked. I further order that any pending application of Scott W. Houghton, M.D...

Developing improved MD codes for understanding processive cellulases

International Nuclear Information System (INIS)

Crowley, M F; Nimlos, M R; Himmel, M E; Uberbacher, E C; Iii, C L Brooks; Walker, R C

2008-01-01

The mechanism of action of cellulose-degrading enzymes is illuminated through a multidisciplinary collaboration that uses molecular dynamics (MD) simulations and expands the capabilities of MD codes to allow simulations of enzymes and substrates on petascale computational facilities. There is a class of glycoside hydrolase enzymes called cellulases that are thought to decrystallize and processively depolymerize cellulose using biochemical processes that are largely not understood. Understanding the mechanisms involved and improving the efficiency of this hydrolysis process through computational models and protein engineering presents a compelling grand challenge. A detailed understanding of cellulose structure, dynamics and enzyme function at the molecular level is required to direct protein engineers to the right modifications or to understand if natural thermodynamic or kinetic limits are in play. Much can be learned about processivity by conducting carefully designed molecular dynamics (MD) simulations of the binding and catalytic domains of cellulases with various substrate configurations, solvation models and thermodynamic protocols. Most of these numerical experiments, however, will require significant modification of existing code and algorithms in order to efficiently use current (terascale) and future (petascale) hardware to the degree of parallelism necessary to simulate a system of the size proposed here. This work will develop MD codes that can efficiently use terascale and petascale systems, not just for simple classical MD simulations, but also for more advanced methods, including umbrella sampling with complex restraints and reaction coordinates, transition path sampling, steered molecular dynamics, and quantum mechanical/molecular mechanical simulations of systems the size of cellulose degrading enzymes acting on cellulose

Glyoxal contribution to aerosols over Los Angeles

Science.gov (United States)

Balcerak, Ernie

2012-01-01

Laboratory and field studies have indicated that glyoxal (chemical formula OCHCHO), an atmospheric oxidation product of isoprene and aromatic compounds, may contribute to secondary organic aerosols in the atmosphere, which can block sunlight and affect atmospheric chemistry. Some aerosols are primary aerosols, emitted directly into the atmosphere, while others are secondary, formed through chemical reactions in the atmosphere. Washenfelder et al. describe in situ glyoxal measurements from Pasadena, Calif., near Los Angeles, made during summer 2010. They used three different methods to calculate the contribution of glyoxal to secondary atmospheric aerosol and found that it is responsible for 0-0.2 microgram per cubic meter, or 0-4%, of the secondary organic aerosol mass. The researchers also compared their results to those of a previous study that calculated the glyoxal contribution to aerosol for Mexico City. Mexico City had higher levels of organic aerosol mass from glyoxal. They suggest that the lower contribution of glyoxal to aerosol concentrations for Los Angeles may be due to differences in the composition or water content of the aerosols above the two cities. (Journal of Geophysical Research-Atmospheres, doi:10.1029/2011JD016314, 2011)

Trends in MD/PhD Graduates Entering Psychiatry: Assessing the Physician-Scientist Pipeline.

Science.gov (United States)

Arbuckle, Melissa R; Luo, Sean X; Pincus, Harold Alan; Gordon, Joshua A; Chung, Joyce Y; Chavez, Mark; Oquendo, Maria A

2018-06-01

The goal of this study was to identify trends in MD/PhD graduates entering psychiatry, to compare these trends with other specialties, and to review strategies for enhancing the physician-scientist pipeline. Data on 226,588 medical students graduating from Liaison Committee on Medical Education accredited programs between 1999 and 2012 (6626 MD/PhDs) were used to evaluate the number, percentage, and proportion of MD/PhDs entering psychiatry in comparison with other specialties (neurology, neurosurgery, internal medicine, family medicine, and radiation oncology). Linear regression and multiple linear regression determined whether these values increased over time and varied by sex. Over 14 years, an average of 18 MD/PhDs (range 13-29) enrolled in psychiatry each year. The number of MD/PhDs going into psychiatry significantly increased, although these gains were modest (less than one additional MD/PhD per year). The proportion of students entering psychiatry who were MD/PhDs varied between 2.9 and 5.9 per 100 residents, with no significant change over time. There was also no change in the percentage of MD/PhDs entering psychiatry from among all MD/PhD graduates. The rate of increase in the number of MD/PhDs going into psychiatry did not differ significantly from other specialties except for family medicine, which is decreasing. The rate of MD/PhDs going into psychiatry was higher for women, suggesting closure of the sex gap in 17 years. Despite the increase in the number of MD/PhDs entering psychiatry, these numbers remain low. Expanding the cohort of physician-scientists dedicated to translational research in psychiatry will require a multipronged approach.

Characterization of an Autophagy-related Gene MdATG8i from apple

Directory of Open Access Journals (Sweden)

Ping eWang

2016-05-01

Full Text Available Nutrient deficiencies restrict apple (Malus sp. tree growth and productivity in Northwest China. The process of autophagy, a conserved degradation pathway in eukaryotic cells, has important roles in nutrient-recycling and helps improve plant performance during periods of nutrient-starvation. Little is known about the functioning of autophagy-related genes (ATGs in apple. In this study, one of the ATG8 gene family members MdATG8i was isolated from M. domestica. MdATG8i has conserved putative tubulin binding sites and ATG7 interaction domains. A 1865-bp promoter region cloned from apple genome DNA was predicated to have cis-regulatory elements responsive to light, environmental stresses and hormones. MdATG8i transcriptions were induced in response to leaf senescence, nitrogen depletion, and oxidative stress. At cellular level, MdATG8i protein was expressed in the nucleus and cytoplasm of onion epidermal cells. Yeast two-hybrid tests showed that MdATG8i could interact with MdATG7a and MdATG7b. In Arabidopsis, its heterologous expression was associated with enhanced vegetative growth, leaf senescence, and tolerance to nitrogen- and carbon-starvation. MdATG8i-overexpressing ‘Orin’ apple callus lines also displayed improved tolerance to nutrient-limited conditions. Our results demonstrate that MdATG8i protein could function in autophagy in a conserved way, as a positive regulator in the response to nutrient-starvation.

[MD PhD programs: Providing basic science education for ophthalmologists].

Science.gov (United States)

Spaniol, K; Geerling, G

2015-06-01

Enrollment in MD PhD programs offers the opportunity of a basic science education for medical students and doctors. These programs originated in the USA where structured programs have been offered for many years, but now German universities also run MD PhD programs. The MD PhD programs provided by German universities were investigated regarding entrance requirements, structure and financing modalities. An internet and telephone-based search was carried out. Out of 34 German universities 22 offered MD PhD programs. At 15 of the 22 universities a successfully completed course of studies in medicine was required for enrollment, 7 programs admitted medical students in training and 7 programs required a medical doctoral thesis, which had to be completed with at least a grade of magna cum laude in 3 cases. Financing required scholarships in many cases. Several German universities currently offer MD PhD programs; however, these differ considerably regarding entrance requirements, structure and financing. A detailed analysis investigating the success rates of these programs (e.g. successful completion and career paths of graduates) would be of benefit.

77 FR 25128 - Amended Land Management Plans for the Angeles, Cleveland, Los Padres, and San Bernardino National...

Science.gov (United States)

2012-04-27

..., Los Padres, and San Bernardino National Forests, California AGENCY: Forest Service, USDA. ACTION... amendment of the Land Management Plans for the Angeles, Cleveland, Los Padres, and San Bernardino National... Angeles, Cleveland, Los Padres, and San Bernardino National Forests, collectively, ``four forests...

3MdB: the Mexican Million Models database

Science.gov (United States)

Morisset, C.; Delgado-Inglada, G.

2014-10-01

The 3MdB is an original effort to construct a large multipurpose database of photoionization models. This is a more modern version of a previous attempt based on Cloudy3D and IDL tools. It is accessed by MySQL requests. The models are obtained using the well known and widely used Cloudy photoionization code (Ferland et al, 2013). The database is aimed to host grids of models with different references to identify each project and to facilitate the extraction of the desired data. We present here a description of the way the database is managed and some of the projects that use 3MdB. Anybody can ask for a grid to be run and stored in 3MdB, to increase the visibility of the grid and the potential side applications of it.

[Bedside implantation of a new temporary vena cava inferior filter : German results from the European ANGEL registry].

Science.gov (United States)

Baumann, S; Becher, T; Giannakopoulos, K; Jabbour, C; Fastner, C; El-Battrawy, I; Ansari, U; Lossnitzer, D; Behnes, M; Alonso, A; Kirschning, T; Dissmann, R; Kueck, O; Stern, D; Michels, G; Borggrefe, M; Akin, I

2018-04-01

Pulmonary embolism (PE) is a frequently occurring complication in critically ill patients, and the simultaneous occurrence of PE and life-threatening bleeding is a therapeutic dilemma. Inferior vena cava filters (IVCF) may represent an important therapeutic alternative in these cases. The Angel® catheter (Bio2 Medical Inc., San Antonio, TX, USA) is a novel IVCF that provides temporary protection from PE and is implanted at bedside without fluoroscopy. The European Angel® Catheter Registry is an observational, multicenter study. In our German substudy, we investigated patients from three German hospitals and four intensive care units, who underwent Angel® catheter implantation between February 2016 and December 2016. A total of 23 critically ill patients (68 ± 9 years, 43% male) were included. The main indication for implantation was a high risk for or an established PE, combined with contraindications for prophylactic or therapeutic anticoagulation due to either an increased risk of bleeding (81%) or active bleeding (13%). The Angel® catheter was successfully inserted in all patients at bedside. No PE occurred in patients with an indwelling Angel® catheter. Clots with a diameter larger the 20 mm, indicating clot migration, were detected in 5% of the patients by cavography before filter retrieval. Filter retrieval was uneventful in all of our cases, while filter dislocation occurred in 3% of the patients. The German data from the multicenter European Angel® Catheter Registry show that the Angel® catheter is a safe and effective approach for critically ill patients with a high risk for the development of PE or an established PE, when an anticoagulation therapy is contraindicated.

Multi-Device to Multi-Device (MD2MD Content-Centric Networking Based on Multi-RAT Device

Directory of Open Access Journals (Sweden)

Cheolhoon Kim

2017-11-01

Full Text Available This paper proposes a method whereby a device can transmit and receive information using a beacon, and also describes application scenarios for the proposed method. In a multi-device to multi-device (MD2MD content-centric networking (CCN environment, the main issue involves searching for and connecting to nearby devices. However, if a device can’t find another device that satisfies its requirements, the connection is delayed due to the repetition of processes. It is possible to rapidly connect to a device without repetition through the selection of the optimal device using the proposed method. Consequently, the proposed method and scenarios are advantageous in that they enable efficient content identification and delivery in a content-centric Internet of Things (IoT environment, in which multiple mobile devices coexist.

Apple F-box Protein MdMAX2 Regulates Plant Photomorphogenesis and Stress Response

Directory of Open Access Journals (Sweden)

Jian-Ping An

2016-11-01

Full Text Available MAX2 (MORE AXILLARY GROWTH2 is involved in diverse physiological processes, including photomorphogenesis, the abiotic stress response, as well as karrikin and strigolactone signaling-mediated shoot branching. In this study, MdMAX2, an F-box protein that is a homolog of Arabidopsis MAX2, was identified and characterized. Overexpression of MdMAX2 in apple calli enhanced the accumulation of anthocyanin. Ectopic expression of MdMAX2 in Arabidopsis exhibited photomorphogenesis phenotypes, including increased anthocyanin content and decreased hypocotyl length. Further study indicated that MdMAX2 might promote plant photomorphogenesis by affecting the auxin signaling as well as other plant hormones. Transcripts of MdMAX2 were noticeably up-regulated in response to NaCl and Mannitol treatments. Moreover, compared with the wild type, the MdMAX2-overexpressing apple calli and Arabidopsis exhibited increased tolerance to salt and drought stresses. Taken together, these results suggest that MdMAX2 plays a positive regulatory role in plant photomorphogenesis and stress response.

Los Angeles 1-Million tree canopy cover assessment

Science.gov (United States)

Gregory E. McPherson; James R. Simpson; Qingfu Xiao; Wu Chunxia

2008-01-01

The Million Trees LA initiative intends to chart a course for sustainable growth through planting and stewardship of trees. The purpose of this study was to measure Los Angeles's existing tree canopy cover (TCC), determine if space exists for 1 million additional trees, and estimate future benefits from the planting. High resolution QuickBird remote sensing data,...

Waiting time distribution in M/D/1 queueing systems

DEFF Research Database (Denmark)

Iversen, Villy Bæk; Staalhagen, Lars

1999-01-01

The well-known formula for the waiting time distribution of M/D/1 queueing systems is numerically unsuitable when the load is close to 1.0 and/or the results for a large waiting time are required. An algorithm for any load and waiting time is presented, based on the state probabilities of M/D/1...

75 FR 49992 - Peter W.S. Grigg, M.D.; Revocation of Registration

Science.gov (United States)

2010-08-16

... DEPARTMENT OF JUSTICE Drug Enforcement Administration Peter W.S. Grigg, M.D.; Revocation of... Order to Show Cause and Immediate Suspension of Registration to Peter W.S. Grigg, M.D. (Respondent), of... Registration, BG2107856, issued to Peter W.S. Grigg, M.D., be, and it hereby is, revoked. This Order is...

The research of the style of angel lobster eye x-ray optical system

Science.gov (United States)

Cheng, HuaQi; Liu, YuJiao; Zhang, ShaoWei; Hou, LinBao; Li, XingLong

2018-01-01

This paper has developed the theory research of wide field Angel lobster eye X-ray optical system based on the principle of entirely incidence. Combine the configuration characteristic of lobster eye, recommend the conclusion of beam of light focus on the half of radius whether point or parallel light. Designed the microchannel through the principle of real ray trace and got the relationship among different parameters about it using numerical value emulation. Got pixels and illumination pictures validated the wide field focus characteristic of Angel lobster eye by simulating the optical system.

Neighborhood Food Environment, Diet, and Obesity Among Los Angeles County Adults, 2011.

Science.gov (United States)

Mejia, Nelly; Lightstone, Amy S; Basurto-Davila, Ricardo; Morales, Douglas M; Sturm, Roland

2015-09-03

The objective of this study was to examine whether an association exists between the number and type of food outlets in a neighborhood and dietary intake and body mass index (BMI) among adults in Los Angeles County. We also assessed whether this association depends on the geographic size of the food environment. We analyzed data from the 2011 Los Angeles County Health Survey. We created buffers (from 0.25 to 3.0 miles in radius) centered in respondents' residential addresses and counted the number of food outlets by type in each buffer. Dependent variables were weekly intake of fruits and vegetables, sugar-sweetened beverages, and fast food; BMI; and being overweight (BMI ≥25.0 kg/m(2)) or obese (BMI ≥30.0 kg/m(2)). Explanatory variables were the number of outlets classified as fast-food outlets, convenience stores, small food stores, grocery stores, and supermarkets. Regressions were estimated for all sets of explanatory variables and buffer size combinations (150 total effects). Only 2 of 150 effects were significant after being adjusted for multiple comparisons. The number of fast-food restaurants in nonwalkable areas (in a 3.0-mile radius) was positively associated with fast-food consumption, and the number of convenience stores in a walkable distance (in a 0.25-mile radius) was negatively associated with obesity. Little evidence was found for associations between proximity of respondents' homes to food outlets and dietary intake or BMI among adults in Los Angeles County. A possible explanation for the null finding is that shopping patterns are weakly related to neighborhoods in Los Angeles County because of motorized transportation.

PM 10 and ozone control strategy to improve visibility in the los angeles basin

Science.gov (United States)

Farber, Robert J.; Welsing, Peter R.; Rozzi, Carlo

The greater Los Angeles metropolitan area is in violation of the United States Environmental Protection Agency (USEPA) ambient standards for both ozone and PM 10. Accompanying these violations are hazy summer conditions, with current annual median visibility in the inland portions of Los Angeles running about 13 km, and visibilities decreasing to about 3 km on the 90th percentile days (worst days). The USEPA has given the local air pollution control agency until 2010 to bring the area into compliance with these standards. Because of continued population growth, accompanying light industry, dependence on private motor vehicles, and adverse natural meteorological conditions, emission reductions costing billions of dollars will be needed between now and 2010. The combination of emission reductions which will result in the fastest ozone and PM 10 cleanup at the lowest cost are presented. Substantial emission reductions in NO x, reactive hydrocarbons, SO x, ammonia, soot and fugitive dust will result in visibility improvements in the Los Angeles area. However, enactment of this comprehensive control strategy will only improve the annual median visibility to about 20 km and the 90th percentile days to 6.5 km. Significant changes in fine mass will result in relatively small changes in perceived visibility since the human eye is unable to differentiate visual range changes even as large as 40% in an urban landscape typical of Los Angeles.

Developing the MD Explorer

Science.gov (United States)

Howie, Philip V.

1993-04-01

The MD Explorer is an eight-seat twin-turbine engine helicopter which is being developed using integrated product definition (IPD) team methodology. New techniques include NOTAR antitorque system for directional control, a composite fuselage, an all-composite bearingless main rotor, and digital cockpit displays. Three-dimensional CAD models are the basis of the entire Explorer design. Solid models provide vendor with design clarification, removing much of the normal drawing interpretation errors.

MD Anderson's Population Health Approaches to Cancer Prevention.

Science.gov (United States)

Foxhall, Lewis; Moreno, Mark; Hawk, Ernest

2018-02-01

Texas's size and unique population demographics present challenges to addressing the state's cancer burden. The University of Texas MD Anderson Cancer Center is one of 69 National Cancer Institute-designated cancer centers across the United States. While these centers traditionally have focused on research, education and training, and providing research-driven patient care, they are in a unique position to collaboratively advance population health through cancer control. Unlike the traditional academic model of a three-legged stool representing research, education, and patient care, MD Anderson's mission includes a fourth leg that incorporates population health approaches. MD Anderson has leveraged state- and national-level data and freely available resources to develop population-health priorities and a set of evidence-based actions across policy, public and professional education, and community-based clinical service domains to address these priorities. Population health approaches complement dissemination and implementation research and treatment, and will be increasingly needed to address the growing cancer burden in Texas and the nation.

Environmental Assessment. Proposed Air Force Space Division Housing Project, White Point, Los Angeles, California

Science.gov (United States)

1984-07-01

render any potential impactsnegligible. 5 E. Diking, Dredging and Shoreline Structures The project would have no effect on these areas of concern; see3...San Juan Capistrano Indians of Southern California [1812-1826]") and Hugo Reid’s letters I printed in the Los Angeles Star in the 1800’s ( Heizer 1968...California5 n.d. A Brief History of Fort MacArthur. Heizer , R. F. (ed.) 1968 The Indians of Los Angeles County: Hugo Reid’s Letters of 1852

Electromagnetic Transient Response Analysis of DFIG under Cascading Grid Faults Considering Phase Angel Jumps

DEFF Research Database (Denmark)

Wang, Yun; Wu, Qiuwei

2014-01-01

This paper analysis the electromagnetic transient response characteristics of DFIG under symmetrical and asymmetrical cascading grid fault conditions considering phaseangel jump of grid. On deriving the dynamic equations of the DFIG with considering multiple constraints on balanced and unbalanced...... conditions, phase angel jumps, interval of cascading fault, electromagnetic transient characteristics, the principle of the DFIG response under cascading voltage fault can be extract. The influence of grid angel jump on the transient characteristic of DFIG is analyzed and electromagnetic response...

76 FR 17673 - Bienvenido Tan, M.D.; Denial of Application

Science.gov (United States)

2011-03-30

... (alprazolam) to help him sleep. Id. at 64. R.E. opted to buy the drugs from Respondent's dispensary and... DEPARTMENT OF JUSTICE Drug Enforcement Administration [Docket No. 09-12] Bienvenido Tan, M.D... Control, Drug Enforcement Administration, issued an Order to Show Cause to Bienvenido Tan, M.D...

Angels as Mirrors of the Human: The Anthropologies of Rilke and Bonaventure through the Lenses of Hans Urs von Balthasar

Directory of Open Access Journals (Sweden)

Yves De Maeseneer

2016-07-01

Full Text Available In this article we present a theological-anthropological exploration, interpreting the figure of the angel as a mirror of our human condition. The point of departure is an analysis of Hans Urs von Balthasar’s approach to two major sources of our imagination of the angel: Bonaventure (1221−1274 and Maria Rainer Rilke (1875−1926. A comparison of his accounts of the Franciscan theologian and the Modern poet, respectively, reveals remarkable parallels in discourse, clustered around the tensions between vulnerability and openness, immanence and transcendence, and love and loss. Both Rilke and Bonaventure reject the classical angel figure as a human ideal, as it cannot integrate the paradoxes of human existence. Their alternative visions of what it means to be human, have many terms in common: heart, vulnerability, mortality, openness, abyss, suspension, transparency, receptivity, descent (kenosis, humility, poverty, etc. However, their meaning is different because Rilke does not recognize an absolute transcendence as the source of love and the vis-a-vis of the human. This immanentism leaves him no other option than the vain attempt to exorcize the angel figure altogether, while Bonaventure’s vision preserves the angel as an anthropological mirror, albeit an angel radically transfigured by God’s wounded love.

Evaluation of hydroacid complex in the forward osmosis–membrane distillation (FO–MD) system for desalination

KAUST Repository

Wang, Peng; Cui, Yue; Ge, Qingchun; Fern Tew, Tjin; Chung, Neal Tai-Shung

2015-01-01

The incorporation of membrane distillation (MD) into forward osmosis (FO) provides process sustainability to regenerate the draw solution and to produce clean water simultaneously. However, the reverse salt flux is the major hurdle in the FO-MD system because it not only reduces the effective osmotic driving force across the membrane but also increases the replenishment cost and scaling issue. For the first time, a hydroacid complex with abundant hydrophilic groups and ionic species is evaluated as the draw solutes in the hybrid FO-MD system consisting of multi-bore PVDF MD membranes for seawater/brackish desalination. In order to evaluate the practicality of the hydroacid complex in the FO-MD system, FO and MD experiments were conducted at elevated temperatures and concentrations. The hydroacid complex has displayed desired properties such as high solubility, low viscosity, excellent thermal stability and minimal reverse salt flux suitable for FO and MD operations. FO-MD desalination process was demonstrated with a highest seawater desalination flux of 6/32 LMH (FO/MD). This study may open up the prospective of employing the hydroacid complex as the draw solute in FO-MD hybrid systems for seawater /brackish desalination. © 2015 Elsevier B.V.

Evaluation of hydroacid complex in the forward osmosis–membrane distillation (FO–MD) system for desalination

KAUST Repository

Wang, Peng

2015-11-01

The incorporation of membrane distillation (MD) into forward osmosis (FO) provides process sustainability to regenerate the draw solution and to produce clean water simultaneously. However, the reverse salt flux is the major hurdle in the FO-MD system because it not only reduces the effective osmotic driving force across the membrane but also increases the replenishment cost and scaling issue. For the first time, a hydroacid complex with abundant hydrophilic groups and ionic species is evaluated as the draw solutes in the hybrid FO-MD system consisting of multi-bore PVDF MD membranes for seawater/brackish desalination. In order to evaluate the practicality of the hydroacid complex in the FO-MD system, FO and MD experiments were conducted at elevated temperatures and concentrations. The hydroacid complex has displayed desired properties such as high solubility, low viscosity, excellent thermal stability and minimal reverse salt flux suitable for FO and MD operations. FO-MD desalination process was demonstrated with a highest seawater desalination flux of 6/32 LMH (FO/MD). This study may open up the prospective of employing the hydroacid complex as the draw solute in FO-MD hybrid systems for seawater /brackish desalination. © 2015 Elsevier B.V.

Letting Los Angeles Go: Lessons from Feral Landscapes

Directory of Open Access Journals (Sweden)

Joan Woodward

2004-06-01

Full Text Available Los Angeles is home to numerous feral landscapes: designed gardens no longer receiving intentional care. These are cultivated gardens, usually composed of plants from myriad global climate types, which have been abandoned or neglected and have adapted to native rainfall or unintentional water sources such as broken irrigation systems. They are found in canyons and ridges swept by fire, along rights-of-way where properties were condemned for freeways, in once-glorious neighbourhoods fallen on hard times, and in places where speculation places properties on hold. They are found in all regions and are particularly vivid in Los Angeles, proclaimed as "Lurch City" by Cuff (2000, where disruptive urban convulsions are frequent. These sites are rich with information pertinent to conceivable futures in which supplemental resources and care may not be reliable. This article portrays selected feral landscapes, briefly describes their responses to pervasive urban forces over time, and extracts design attributes to consider when creating future resilient landscapes. Scrutiny of these landscapes' decline and tenacity reveals a telling view of a region's volatility and global context and reminds us to take into account probable neglect when shaping future landscapes.

77 FR 5201 - Drawbridge Operation Regulation; Bear Creek, Dundalk, MD

Science.gov (United States)

2012-02-02

...-AA09 Drawbridge Operation Regulation; Bear Creek, Dundalk, MD AGENCY: Coast Guard, DHS. ACTION: Notice... operation of the Baltimore County highway bridge at Wise Avenue across Bear Creek, mile 3.4, between Dundalk... Avenue across Bear Creek, mile 3.4 between Dundalk and Sparrows Point, MD. This change would require the...

Analysis of MD5 authentication in various routing protocols using simulation tools

Science.gov (United States)

Dinakaran, M.; Darshan, K. N.; Patel, Harsh

2017-11-01

Authentication being an important paradigm of security and Computer Networks require secure paths to make the flow of the data even more secure through some security protocols. So MD-5(Message Digest 5) helps in providing data integrity to the data being sent through it and authentication to the network devices. This paper gives a brief introduction to the MD-5, simulation of the networks by including MD-5 authentication using various routing protocols like OSPF, EIGRP and RIPv2. GNS3 is being used to simulate the scenarios. Analysis of the MD-5 authentication is done in the later sections of the paper.

The Criminalization of Black Angeleno Women: Institutionalized Racism and Sexism in Los Angeles, 1928-1938

OpenAIRE

Boyd, Kaitlin Therese

2012-01-01

"The Criminalization of Black Angeleno Women" illuminates what happened in early 20th century Los Angeles when African American women, particularly working poor females, came into contact with the Los Angeles Police Department, the court system and the local, mainstream media. Individually, but especially collaboratively, these institutions lead to the overrepresentation of Black, statistically and in the public mind, in the local sex trade. Essentially, this thesis traces the biases of the...

PORTRAIT IN LITERATURE AND GRAPHIC ART: THE CASE OF THE FIERY ANGEL

Directory of Open Access Journals (Sweden)

Natalia A. Drovaleva

2017-06-01

Full Text Available This essay analyzes portraits in several editions of The Fiery Angel published during This essay analyzes portraits in several editions of The Fiery Angel published during Bryusov’s lifetime and claims that the portrait was as a universal point of convergence for verbal and visual arts. The dialogue between literature and graphics in the context of the synthesis of arts sheds new light on the possibilities for interdisciplinary research. The time of the “beautiful book” was a time of great artists and illustrators who introduced the peculiarities of their own style and the manner of their artistic schools into their art. Books were commonly decorated with vignettes and famous paintings. Portraits, as well as plates in general, were of the highest quality. They were ornamental and illusory, with every minute detail finely drawn out. Yet, in the second edition of the novel Bryusov deliberately included medieval engravings and portraits. A comparative analysis of the verbal portraits in The Fiery Angel and engraved portraits in the book (Ruprecht, Heinrich, Faust, Mephistopheles, Renata, and Madiel demonstrates that both the main and the secondary characters of the novel are picturesque and multidimensional whereas the xylographic portraits rather reveal conventionality and simplicity of the medieval time. This way Bryusov was seeking to debase clichе’s, especially as regards Agrippa von Nettesheim and Faust: according to Bryusov, the character of Agrippa had already become a clichе’d image and so was the popular engraving of the scientist that he reproduced in the middle of the sixth chapter of the 1909 edition. Juxtaposing the verbal and the graphic portraits in The Fiery Angel helps us better understand the function of the verbal portrait in a Symbolist text that was determined by the author’s design, on the one hand, and by various “instruments” of different arts, on the other.

Can acceptable quality angel food cakes be made using pasteurized shell eggs? The effects of processing factors on functional properties of angel food cakes

Science.gov (United States)

Due to recent incidences of Salmonella contamination, the market for pasteurized shell eggs is rapidly growing. One objection to using pasteurized shell eggs is the belief that they will produce unacceptable baked product (e.g., angel food cakes). In the present study, shell eggs were pasteurized us...

Osmotically and thermally isolated forward osmosis-membrane distillation (fo-md) integrated module for water treatment applications

KAUST Repository

Ghaffour, Noreddine

2016-09-01

An integrated forward osmosis-membrane distillation (FO-MD) module and systems and methods incorporating the module is disclosed providing higher efficiencies and using less energy. The FO-MD module is osmotically and thermally isolated. The isolation can prevent mixing of FO draw solution/FO permeate and MD feed, and minimize dilution of FO draw solution and cooling of MD feed. The module provides MD feed solution and FO draw solution streams that flow in the same module but are separated by an isolation barrier. The osmotically and thermally isolated FO-MD integrated module, systems and methods offer higher driving forces of both FO and MD processes, higher recovery, and wider application than previously proposed hybrid FO- MD systems.

Osmotically and thermally isolated forward osmosis-membrane distillation (fo-md) integrated module for water treatment applications

KAUST Repository

Ghaffour, NorEddine; Francis, Lijo; Li, Zhenyu; Valladares, Rodrigo; Alsaadi, Ahmad S.; Ghdaib, Muhannad Abu; Amy, Gary L.

2016-01-01

An integrated forward osmosis-membrane distillation (FO-MD) module and systems and methods incorporating the module is disclosed providing higher efficiencies and using less energy. The FO-MD module is osmotically and thermally isolated. The isolation can prevent mixing of FO draw solution/FO permeate and MD feed, and minimize dilution of FO draw solution and cooling of MD feed. The module provides MD feed solution and FO draw solution streams that flow in the same module but are separated by an isolation barrier. The osmotically and thermally isolated FO-MD integrated module, systems and methods offer higher driving forces of both FO and MD processes, higher recovery, and wider application than previously proposed hybrid FO- MD systems.

33 CFR 110.70a - Northeast River, North East, Md.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Northeast River, North East, Md. 110.70a Section 110.70a Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.70a Northeast River, North East, Md. The water...

Pengaruh Brand Ambassador Terhadap Minat Beli Konsumen MD Clinic By Lazeta

Directory of Open Access Journals (Sweden)

Nurvita Septya Ningrum

2016-10-01

Full Text Available This research at MD Clinic by Lazeta which is in the beauty services that offer health care and facial, under of PT. Medina Global Care. MD Cilinic by Lazeta use the brand ambassador of introducing their products. The selection of brand ambassador motivated by positive image brought by the celebrities. Brand ambassadors chosen by the company as a symbol or a marker to represent the wishes and needs of prospective customers. MD Clinic by Lazeta choose Syahnaz as a brand ambassador for their products which is expected to to represent the product of MD Clinic by Lazeta, so the message can be understood by the consumer, who eventually would to lead the purchase intention. The purpose of this research was to investigate the influence of brand ambassadors on consumer purchase intention MD Clinic by Lazeta, Study on Business Administration Students year in 2103 Telkom University. Researchers used quantitative research methods. This research is population research, because all population is being respondent in this research. Populations of this research are 137 respondents. Collecting data in this research is conducted by using questionnaire distributed to all respondents, which all Students on Business Administration Telkom University who knows the MD Clinic by Lazeta. Data were analyzed using simple regression analysis and descriptive analysis.The results showed that the Brand Ambassador impact of consumer purchase intention on MD Clinic by Lazeta at the Students on Business Administration Telkom University years in 2013. Based on the calculation of the coefficient of determination (R2 can be seen the influence of brand ambassador variable (X on purchase intention (Y is 42.9%. While the remaining 57.1% is influenced by other factors which not examined in this research such as, pricing, marketing strategy and others.

77 FR 29692 - Segun M. Rasaki, M.D.; Decision and Order

Science.gov (United States)

2012-05-18

... CFR 1316.67. Dated: May 4, 2012. Michele M. Leonhart, Administrator. Paul E. Soeffing, Esq., for the... reinstatement.'' Stuart A. Bergman, M.D., 70 Fed. Reg. 33,193 (DEA 2005); Roger A. Rodriguez, M.D., 70 Fed. Reg...

77 FR 35021 - Kwan Bo Jin, M.D.; Decision and Order

Science.gov (United States)

2012-06-12

...] DEA registration is not appropriate.'' Anibal P. Herrera, M.D., 61 FR 65,075, 65,078 (DEA 1996); see... ``there were serious questions as to the integrity of the registrant.'' Anibal P. Herrera, M.D., 61 FR 65...

Molecular Cloning and Expression Analysis of a Hexokinase Gene, MdHXK1 in Apple

Directory of Open Access Journals (Sweden)

Jin Zhao

2016-03-01

Full Text Available A hexokinase gene named MdHXK1 (MDP0000309677 was cloned from ‘Gala’ apple (Malus × domestica Borkh.. Sequence analysis showed that the MdHXK1 gene was 1 497 bp long and encoded 499 amino acids. The predicted molecular mass of this protein was 54.05 kD, and the pI was 5.76. A phylogenetic tree indicated apple MdHXK1 exhibited the highest sequence similarity to Pyrus bretschneideri PbHXK1. Analysis of the functional domain showed that the MdHXK1 protein included two conserved kinase domains. The prediction of subcellular localization suggested that the MdHXK1 protein was mainly localized in the cytoplasm. There was an indication that MdHXK1 existed as one copy in the apple genome by Southern blotting. Silico analysis suggested that the promoter sequence contained several typical cis-acting elements, including defense, sugar signaling and phytohormone responsive elements. Quantitative real-time PCR analysis demonstrated that the MdHXK1 gene was mainly expressed in stem and flower tissues. During the development of apple fruits, the expression of the MdHXK1 gene initially increased and then decreased. The changes on Glc phosphorylation relative activity and glucose concentration showed the same trend. In addition, the expression of this gene was induced by salt stress, low temperature, and abscisic acid (ABA. Finally, we obtained and purified the fused MdHXK1 protein by recombinant prokaryotic expression. Studies have demonstrated that MdHXK1 may participate in sugar metabolism in apple fruits. Enzyme encoded by MdHXK1 is a key factor in the mediation of sugar accumulation. Recently, researchers on hexokinase at home and abroad mainly focused on model plants, such as Arabidopsis, tobacco and rice, but orchard fruit like apple were underresearched. Our research established the foundation for the further study of the functions of MdHXK1.

A pilot study of MD (psychiatry) theses-based research.

Science.gov (United States)

Srivastava, Shrikant; Agarwal, Vivek; Subramanyam, Alka; Srivastava, Mona; Sathyanarayana Rao, T S; Rao, G Prasad; Khurana, Hitesh; Singh, Archana

2018-01-01

Undertaking a research project is mandatory for MD Psychiatry trainees. The present study was undertaken to assess the type of research activity being undertaken as part of MD Psychiatry dissertation, and its contribution to national and international literature. Three medical colleges supplied the data about the topic, names of the supervisor and the candidate, collaboration, funding accrued, and publication details of MD-based research carried out between years 2000 and 2010 inclusive; 95 records were collected for the final analysis. The details of the publications provided were cross-checked on the internet, which would have taken care of missed publications as well. Most studies were single-point assessment clinical studies. Only 2 studies had been funded, 11 had collaboration with other departments within the same institute, and 5 had inter-institute collaborations. Majority of the studies were not published. Only 30 were published as full paper and 9 as abstracts. Of these 30 full publications, only 3 were published in journals having JCI impact factor values (1.4, 1.3, and 1.4, respectively). The main finding of this pilot study was that MD-based research has low contribution to the national and international literature, and those articles which are published are in low impact journals. Suggestions for modifying this state of affairs are discussed.

MD 2485: Active halo control using narrowband and colored noise excitations

CERN Document Server

Garcia Morales, Hector; Kotzian, Gerd; Maclean, Ewen Hamish; Redaelli, Stefano; Valuch, Daniel; Wagner, Joschka; CERN. Geneva. ATS Department

2018-01-01

This MD note summarizes the actions carried out during the MD 2485 on Active halo control using narrowband and colored noise excitations. The goal of the MD was to repeat some promising cases already tested in the past and introduce a new excitation type based on applying a colored noise. Although we were able to repeat some cases using a narrowband excitation, due to a problem with the waveform generator, the colored noise excitation could not be accomplished as expected. In any case, we provide some results that may be useful for future MDs.

Rhodotorula taiwanensis MD1149 produces hypoacetylated PEFA compounds with increased surface activity compared to Rhodotorula babjevae MD1169

Science.gov (United States)

Rubinfeld, Bonnee; Leif, Roald; Mulcahy, Heather; Dugan, Lawrence; Souza, Brian

2018-01-01

Biosurfactants have several desirable characteristics in the industrial sector: detergency, antimicrobial effects, skin hydration, and emulsibility. Several yeast glycolipids are currently being utilized in these capacities: sophorolipids, ustilagic acid, and mannosylerythritol lipids (MELs). An emerging class of glycolipids, termed polyol esters of fatty acids (PEFA), have recently been reported for Rhodotorula babjevae, a basidiomycetous yeast species that secretes hyperacetylated congeners of PEFA (typically with 3–6 acetylation modifications). While screening Rhodotorula species for surfactant production, we identified a new environmental isolate identified as Rhodotorula taiwanensis MD1149 that dropped the surface tension of the liquid medium, indicating that it produced a potent biosurfactant. Acid depolymerization of the purified biosurfactants, followed by gas chromatography-mass spectrometry (GC-MS) analysis revealed that the biosurfactants were composed of PEFA compounds composed mainly of mannitol and arabitol esters of 3-hydroxy fatty acid, 3-methoxy fatty acid, and fatty acids with a single double bond; chain lengths were mainly C16 and C18. Liquid chromatography-mass spectrometry (LC-MS) confirmed the predicted accurate mass of these compounds. Interestingly, PEFA compounds produced by Rhodotorula taiwanensis MD1149 were more surface active due to their hypoacetylation profile (0–4 acetylation modifications) compared to Rhodotorula babjevae MD1169. These disparate surface active properties, based on acetylation, change the hydrophilic-lipophilic balance (HLB) of these compounds, and their potential utility within industrial applications. PMID:29293588

Rhodotorula taiwanensis MD1149 produces hypoacetylated PEFA compounds with increased surface activity compared to Rhodotorula babjevae MD1169.

Science.gov (United States)

Lyman, Mathew; Rubinfeld, Bonnee; Leif, Roald; Mulcahy, Heather; Dugan, Lawrence; Souza, Brian

2018-01-01

Biosurfactants have several desirable characteristics in the industrial sector: detergency, antimicrobial effects, skin hydration, and emulsibility. Several yeast glycolipids are currently being utilized in these capacities: sophorolipids, ustilagic acid, and mannosylerythritol lipids (MELs). An emerging class of glycolipids, termed polyol esters of fatty acids (PEFA), have recently been reported for Rhodotorula babjevae, a basidiomycetous yeast species that secretes hyperacetylated congeners of PEFA (typically with 3-6 acetylation modifications). While screening Rhodotorula species for surfactant production, we identified a new environmental isolate identified as Rhodotorula taiwanensis MD1149 that dropped the surface tension of the liquid medium, indicating that it produced a potent biosurfactant. Acid depolymerization of the purified biosurfactants, followed by gas chromatography-mass spectrometry (GC-MS) analysis revealed that the biosurfactants were composed of PEFA compounds composed mainly of mannitol and arabitol esters of 3-hydroxy fatty acid, 3-methoxy fatty acid, and fatty acids with a single double bond; chain lengths were mainly C16 and C18. Liquid chromatography-mass spectrometry (LC-MS) confirmed the predicted accurate mass of these compounds. Interestingly, PEFA compounds produced by Rhodotorula taiwanensis MD1149 were more surface active due to their hypoacetylation profile (0-4 acetylation modifications) compared to Rhodotorula babjevae MD1169. These disparate surface active properties, based on acetylation, change the hydrophilic-lipophilic balance (HLB) of these compounds, and their potential utility within industrial applications.

78 FR 47412 - Tyson D. Quy, M.D.; Decision and Order

Science.gov (United States)

2013-08-05

... Green, Jr., M.D., 59 FR 51,453 (DEA 1994); David E. Trawick, D.D.S., 53 FR 5,326 (DEA 1988). Here, the...) (ten years); Norman Alpert, M.D., 58 FR 67,420, 67,421 (DEA 1993) (seven years). Here, the conditions...

Alcohol outlet density and alcohol consumption in Los Angeles county and southern Louisiana

Directory of Open Access Journals (Sweden)

Matthias Schonlau

2008-11-01

Full Text Available The objective of this study was to assess the relationship between alcohol availability, as measured by the density of off-premise alcohol outlets, and alcohol consumption in Los Angeles county and southern Louisiana, USA. Consumption information was collected through a telephone survey of 2,881 households in Los Angeles county and pre-Katrina southern Louisiana, nested within 220 census tracts. Respondents’ addresses were geo-coded and both neighbourhood (census tracts and buffers of varying sizes and individual (network distance to the closest alcohol outlet estimates of off-sale alcohol outlet density were computed. Alcohol outlet density was not associated with the percentage of people who were drinkers in either site. Alcohol outlet density was associated with the quantity of consumption among drinkers in Louisiana but not in Los Angeles. Outlet density within a one-mile buffer of the respondent’s home was more strongly associated with alcohol consumption than outlet density in the respondent’s census tract. The conclusion is that the relationship between neighbourhood alcohol outlet density and alcohol consumption is complex and may vary due to differences in neighbourhood design and travel patterns.

Functional Characterization of the Apple RING E3 Ligase MdMIEL1 in Transgenic Arabidopsis

Directory of Open Access Journals (Sweden)

Jianping AN

2017-03-01

Full Text Available E3 ubiquitin ligases are involved in various physiological processes, and they play pivotal roles in growth and development. In this study, we identified a previously unknown gene in the apple fruit (Malus × domestica and named it MdMIEL1. The MdMIEL1 gene encoded a protein that contained a zinc-finger domain at its N-terminus and a RING-finger motif at its C-terminus. To investigate MdMIEL1 functions, we generated transgenic Arabidopsis lines expressing the MdMIEL1 gene under the control of the Cauliflower mosaic virus 35S promoter. Interestingly, ectopic expression of MdMIEL1 in Arabidopsis produced multiple phenotypes, including early germination, early flowering and a lateral root number increase relative to wild-type plants. Further analysis indicated that MdMIEL1 regulated lateral root initiation by increasing auxin accumulation in the roots. In a word, these results suggest that, MdMIEL1 as a novel RING-finger ubiquitin ligase influences plant growth and development, and highlight that MdMIEL1 regulates lateral root growth.

BayesMD: flexible biological modeling for motif discovery

DEFF Research Database (Denmark)

Tang, Man-Hung Eric; Krogh, Anders; Winther, Ole

2008-01-01

We present BayesMD, a Bayesian Motif Discovery model with several new features. Three different types of biological a priori knowledge are built into the framework in a modular fashion. A mixture of Dirichlets is used as prior over nucleotide probabilities in binding sites. It is trained on trans......We present BayesMD, a Bayesian Motif Discovery model with several new features. Three different types of biological a priori knowledge are built into the framework in a modular fashion. A mixture of Dirichlets is used as prior over nucleotide probabilities in binding sites. It is trained...

Crystal twinning of human MD-2 recognizing endotoxin cores of lipopolysaccharide

International Nuclear Information System (INIS)

Ohto, Umeharu; Satow, Yoshinori

2008-01-01

Twinned crystals of humaan MD-2 are transformed into single crystals with cryoprotectant optimization. Twinning of crystals causes overlapping of two or more reciprocal lattice points, and hence structure amplitudes for a single crystalline domain are hardly obtained from X-ray diffraction intensities. MD-2 protein forms a stable complex with Toll-like receptor 4 and recognizes bacterial lipopolysaccharide (LPS). Excessive immune responses activated by LPS cause septic shocks. Saccharide-trimmed human MD-2 crystallizes in the tetragonal form with apparent Laue symmetry of 4/mmm, and diffraction intensities from these crystals indicate crystal twinning. The crystal consists of two different domains, A and B. The c A axis of domain A coincides with the c B axis of domain B with a smaller lattice, and the a A axis corresponds to the (a B + b B ) axis. This twinning severely imposes difficulty in structure determination. Through optimization of cryoprotectant, domain A was thoroughly transformed into domain B. The crystal containing only domain B is in space group P4 1 2 1 2 with one MD-2 molecule in the asymmetric unit. The structure of this form of MD-2 as well as its complex with antiendotoxic lipid IVa was successfully determined using the multiple isomorphous replacement method

MD on UFOs at MKIs and MKQs

CERN Document Server

Baer, T; Bartmann, W; Bracco, C; Carlier, E; Dehning, B; Garrel, N; Goddard, B; Jackson, S; Jimenez, M; Kain, V; Mertens, V; Misiowiec, M; Nordt, A; Papotti, G; Uythoven, J; Wenninger, J; Zerlauth, M; Zamantzas, C; Zimmermann, F

2012-01-01

UFOs ("Unidentified Falling Objects") are expected to be one of the major known performance limitation of the LHC. In this MD, the production mechanism and the dynamics of UFOs at the injection kicker magnets (MKIs) and the tune kicker magnets (MKQs) were studied. This was done by pulsing the MKIs and MKQs on a gap in the partly filled machine. During the MD, in total 58 UFO-type beam loss patterns were observed directly after pulsing the MKIs. None were observed after pulsing the MKQs, which provides important input for possible mitigation strategies. The temporal and spatial distribution of the UFO events could be determined by using a dedicated BLM Study Buffer, the implications for the UFO dynamics are discussed.

Sustainable water recovery from oily wastewater via forward osmosis-membrane distillation (FO-MD).

Science.gov (United States)

Zhang, Sui; Wang, Peng; Fu, Xiuzhu; Chung, Tai-Shung

2014-04-01

This study proposed and investigated a hybrid forward osmosis - membrane distillation (FO-MD) system for sustainable water recovery from oily wastewater by employing lab-fabricated FO and MD hollow fiber membranes. Stable oil-in-water emulsions of different concentrations with small droplet sizes (oil droplets and partial permeation of acetic acid could be achieved. Finally, an integrated FO-MD system was developed to treat the oily wastewater containing petroleum, surfactant, NaCl and acetic acid at 60 °C in the batch mode. The water flux in FO undergoes three-stage decline due to fouling and reduction in osmotic driving force, but is quite stable in MD regardless of salt concentration. Oily wastewater with relatively high salinity could be effectively recovered by the FO-MD hybrid system while maintaining large water flux, at least 90% feed water recovery could be readily attained with only trace amounts of oil and salts, and the draw solution was re-generated for the next rounds of FO-MD run. Interestingly, significant amount of acetic acid was also retained in the permeate for further reuse as a chemical additive during the production of crude oil. The work has demonstrated that not only water but also organic additives in the wastewater could be effectively recovered by FO-MD systems for reuse or other utilizations. Copyright © 2014 Elsevier Ltd. All rights reserved.

Center of excellence for mobile sensor data-to-knowledge (MD2K).

Science.gov (United States)

Kumar, Santosh; Abowd, Gregory D; Abraham, William T; al'Absi, Mustafa; Beck, J Gayle; Chau, Duen Horng; Condie, Tyson; Conroy, David E; Ertin, Emre; Estrin, Deborah; Ganesan, Deepak; Lam, Cho; Marlin, Benjamin; Marsh, Clay B; Murphy, Susan A; Nahum-Shani, Inbal; Patrick, Kevin; Rehg, James M; Sharmin, Moushumi; Shetty, Vivek; Sim, Ida; Spring, Bonnie; Srivastava, Mani; Wetter, David W

2015-11-01

Mobile sensor data-to-knowledge (MD2K) was chosen as one of 11 Big Data Centers of Excellence by the National Institutes of Health, as part of its Big Data-to-Knowledge initiative. MD2K is developing innovative tools to streamline the collection, integration, management, visualization, analysis, and interpretation of health data generated by mobile and wearable sensors. The goal of the big data solutions being developed by MD2K is to reliably quantify physical, biological, behavioral, social, and environmental factors that contribute to health and disease risk. The research conducted by MD2K is targeted at improving health through early detection of adverse health events and by facilitating prevention. MD2K will make its tools, software, and training materials widely available and will also organize workshops and seminars to encourage their use by researchers and clinicians. © The Author 2015. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

MdHB1 down-regulation activates anthocyanin biosynthesis in the white-fleshed apple cultivar 'Granny Smith'.

Science.gov (United States)

Jiang, Yonghua; Liu, Cuihua; Yan, Dan; Wen, Xiaohong; Liu, Yanli; Wang, Haojie; Dai, Jieyu; Zhang, Yujie; Liu, Yanfei; Zhou, Bin; Ren, Xiaolin

2017-02-01

Coloration in apple (Malus×domestica) flesh is mainly caused by the accumulation of anthocyanin. Anthocyanin is biosynthesized through the flavonoid pathway and regulated by MYB, bHLH, and WD40 transcription factors (TFs). Here, we report that the HD-Zip I TF MdHB1 was also involved in the regulation of anthocyanin accumulation. MdHB1 silencing caused the accumulation of anthocyanin in 'Granny Smith' flesh, whereas its overexpression reduced the flesh content of anthocyanin in 'Ballerina' (red-fleshed apple). Moreover, flowers of transgenic tobacco (Nicotiana tabacum 'NC89') overexpressing MdHB1 showed a remarkable reduction in pigmentation. Transient promoter activation assays and yeast one-hybrid results indicated that MdHB1 indirectly inhibited expression of the anthocyanin biosynthetic genes encoding dihydroflavonol-4-reductase (DFR) and UDP-glucose:flavonoid 3-O-glycosyltransferase (UFGT). Yeast two-hybrid and bimolecular fluorescence complementation determined that MdHB1 acted as a homodimer and could interact with MYB, bHLH, and WD40 in the cytoplasm, consistent with its cytoplasmic localization by green fluorescent protein fluorescence observations. Together, these results suggest that MdHB1 constrains MdMYB10, MdbHLH3, and MdTTG1 to the cytoplasm, and then represses the transcription of MdDFR and MdUFGT indirectly. When MdHB1 is silenced, these TFs are released to activate the expression of MdDFR and MdUFGT and also anthocyanin biosynthesis, resulting in red flesh in 'Granny Smith'. © The Author 2017. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

DEMON/ANGEL - A SUITE OF PROGRAMS TO CARRY OUT DENSITY MODIFICATION

NARCIS (Netherlands)

VELLIEUX, FMDAP; HUNT, JF; ROY, S; READ, RJ

1995-01-01

The DEMON/ANGEL suite of computer programs has been developed to carry out density modification by non-crystallographic symmetry-averaging, solvent-flattening and histogram-mapping techniques. This suite consists of programs that allow molecular envelopes to be defined and modified,

Energy transition or incremental change? Green policy agendas and the adaptability of the urban energy regime in Los Angeles

International Nuclear Information System (INIS)

Monstadt, Jochen; Wolff, Annika

2015-01-01

Drawing on recent research in urban policy studies and social studies of technology, this paper examines the capability of urban energy regimes in adapting to environmental policy pressures. Focusing on the case of the City of Los Angeles, we critically analyze the transformative capacity of the city's recent energy and climate policies and the innovation patterns of its urban infrastructure regime. This case study suggests that despite considerable success in switching from coal to renewable energies, the patterns of sociotechnical change in Los Angeles still tend to supplement and sustain the existing regime. Sociotechnical change in Los Angeles tends to unfold incrementally through adjustments within the established patterns of the existing regime. - Highlights: • Theory-guided case study on the transition of the urban energy regime in Los Angeles. • Evaluation of the transformative capacity of environmental policies. • Assessment of the adaptability and innovation patterns of urban infrastructure regimes. • The policy changes have sustained the existing regime and unfold incrementally

Sexual and Gender Minority Youth in Foster Care: Assessing Disproportionality and Disparities in Los Angeles

OpenAIRE

Wilson, Bianca DM; Cooper, Khush; Kastanis, Angeliki; Nezhad, Sheila

2014-01-01

LGBTQ foster youth are twice as likely to report poor treatment and more likely to live in group homes and to have more foster care placements. Approximately 1 in 5, or 1,400 foster youth in Los Angeles County, home to the nation’s largest population of foster youth, identify as LGBTQ. The finding is twice the estimated percentage of youth not in foster care who are LGBTQ. Generally, LGBTQ foster youth mirror the racial/ethnic demographic of all foster youth in Los Angeles County. The majorit...

Diversity and Educational Challenges in Oslo and Los Angeles - A Metropolitan Perspective nr 2

Directory of Open Access Journals (Sweden)

Kamil ÖZERK

2014-07-01

Full Text Available Receiving, accommodation and education of children with immigrant background is one of the challenging issues in almost all the metropolitan areas in many countries. In our study we are exploring the impact of demographic changes on political agendas, legal frames, educational approaches, research findings and student achievement in the field of education of linguistic minorities in Oslo, Norway and Los Angeles, USA. Although there are significant historical and socio economical differences between Los Angeles and Oslo, many of the educational challenges facing the educational policy makers and the linguistic minority students are quite similar.

The hydration enthalpies of Md3+ and Lr3+

International Nuclear Information System (INIS)

Bruechle, W.; Schaedel, M.; Scherer, U.W.; Kratz, J.V.

1987-10-01

Lawrencium (3-min 260 Lr) and lighter actinides were produced in the bombardement of a 249 Bk target with 18 O ions and loaded onto a cation exchange column in 0.05 M α-hydroxy-isobutyrate solution at pH = 4.85 together with the radioactive lanthanide tracers 166 Ho, 171 Er, and 171 Tm. In elutions with 0.12 M α-hydroxy-isobutyrate solution (pH = 4.85) trivalent Lr was eluted exactly together with the Er tracer and Md close to Ho. Lr elutes much later than expected based on the known elution positions of the lighter actinides and the expected analogy to the elution positions of the homologous lanthanides. From the measured elution positions, ionic radii were calculated for Lr 3+ and Md 3+ . Semiempirical models allow the calculation of the heat of hydration from the ionic radii, resulting in ΔH hyd ≅ - 3654 kJ/mol for Md 3+ and ΔH hyd ≅ - 3689 kJ/mol for Lr 3+ . (orig.)

76 FR 81826 - Drawbridge Operation Regulation; Pocomoke River, Pocomoke City, MD

Science.gov (United States)

2011-12-29

... Operation Regulation; Pocomoke River, Pocomoke City, MD AGENCY: Coast Guard, DHS. ACTION: Notice of... River, mile 15.6, at Pocomoke City, MD. The deviation restricts the operation of the draw span to... five hours advance notice is given. The Route 675 Bridge across Pocomoke River, mile 15.6 at Pocomoke...

The molecular mechanism underlying anthocyanin metabolism in apple using the MdMYB16 and MdbHLH33 genes.

Science.gov (United States)

Xu, Haifeng; Wang, Nan; Liu, Jingxuan; Qu, Changzhi; Wang, Yicheng; Jiang, Shenghui; Lu, Ninglin; Wang, Deyun; Zhang, Zongying; Chen, Xuesen

2017-05-01

MdMYB16 forms homodimers and directly inhibits anthocyanin synthesis via its C-terminal EAR repressor. It weakened the inhibitory effect of MdMYB16 on anthocyanin synthesis when overexpressing MdbHLH33 in callus overexpressing MdMYB16. MdMYB16 could interact with MdbHLH33. Anthocyanins are strong antioxidants that play a key role in the prevention of cardiovascular disease, cancer, and diabetes. The germplasm of Malus sieversii f. neidzwetzkyana is important for the study of anthocyanin metabolism. To date, only limited studies have examined the negative regulatory mechanisms underlying anthocyanin synthesis in apple. Here, we analyzed the relationship between anthocyanin levels and MdMYB16 expression in mature Red Crisp 1-5 apple (M. domestica) fruit, generated an evolutionary tree, and identified an EAR suppression sequence and a bHLH binding motif of the MdMYB16 protein using protein sequence analyses. Overexpression of MdMYB16 or MdMYB16 without bHLH binding sequence (LBSMdMYB16) in red-fleshed callus inhibited MdUFGT and MdANS expression and anthocyanin synthesis. However, overexpression of MdMYB16 without the EAR sequence (LESMdMYB16) in red-fleshed callus had no inhibitory effect on anthocyanin. The yeast one-hybrid assay showed that MdMYB16 and LESMdMYB16 interacted the promoters of MdANS and MdUFGT, respectively. Yeast two-hybrid, pull-down, and bimolecular fluorescence complementation assays showed that MdMYB16 formed homodimers and interacted with MdbHLH33, however, the LBSMdMYB16 could not interact with MdbHLH33. We overexpressed MdbHLH33 in callus overexpressing MdMYB16 and found that it weakened the inhibitory effect of MdMYB16 on anthocyanin synthesis. Together, these results suggested that MdMYB16 and MdbHLH33 may be important part of the regulatory network controlling the anthocyanin biosynthetic pathway.

Los Angeles County Metropolitan Transportation Authority climate change adaptation pilot project report.

Science.gov (United States)

2013-08-01

This Climate Change Adaptation Pilot Project Report details the project background of the recently-completed Los Angeles County : Metropolitan Transportation Authority (Metro) Transit Climate Change Adaptation Pilot Project as well as the various wor...

Unauthorized Mexican workers in the 1990 Los Angeles County labour force.

Science.gov (United States)

Marcelli, E A; Heer, D M

1997-01-01

"By analysing how unauthorized Mexicans compare with seven other ethno-racial groups in Los Angeles County, separately and collectively, by educational attainment and time spent in the U.S., we find that unauthorized Mexicans had relatively fewer years of formal education (either in the U.S. or in Mexico) and had been in the U.S. a relatively fewer number of years than in-migrants of other ethno-racial backgrounds in 1990. These findings are then used as proxies to compare the human capital endowments of different ethno-racial groups. We next estimate the number of unauthorized Mexicans by occupation, industry and class of worker, and compare these distributions with the total labour force and with the other ethno-racial groups in Los Angeles County.... Results show that amounts of human capital are positively related to the kinds of occupations filled." (SUMMARY IN FRE AND SPA) excerpt

Rikaste klubi hindab Eesti reformikogemust / Angel Gurria ; interv. Sirje Rank

Index Scriptorium Estoniae

Gurria, Angel, 1950-

2008-01-01

Majandusliku Koostöö ja Arengu Organisatsiooni (OECD) peasekretär Angel Gurria ütleb intervjuus Äripäevale, et Eesti on oodatud rikaste riikide klubisse eelkõige oma reformikogemuse tõttu, ette heitis ta aga Eesti tööturu jäikust. Kommenteerib välisminister Urmas Paet. Lisa: Taust

Designing an Innovative Data Architecture for the Los Angeles Data Resource (LADR).

Science.gov (United States)

Mukherjee, Sukrit; Jenders, Robert A; Delta, Sebastien

2015-01-01

The Los Angeles Data Resource (LADR) is a joint project of major Los Angeles health care provider organizations. The LADR helps clinical investigators to explore the size of potential research study cohorts using operational clinical data across all participating institutions. The Charles R. Drew University of Medicine and Science (CDU) LADR team sought to develop an innovative data architecture that would aggregate de-identified clinical data from safety-net providers in the community into CDU LADR node. This in turn would be federated with the other nodes of LADR for a shared view in a way that was never available before. This led to a self-service system to assess patients matching study criteria at each medical center and to search patients by demographics, ICD-9 codes, lab results and medications.

PuReMD-GPU: A reactive molecular dynamics simulation package for GPUs

International Nuclear Information System (INIS)

Kylasa, S.B.; Aktulga, H.M.; Grama, A.Y.

2014-01-01

We present an efficient and highly accurate GP-GPU implementation of our community code, PuReMD, for reactive molecular dynamics simulations using the ReaxFF force field. PuReMD and its incorporation into LAMMPS (Reax/C) is used by a large number of research groups worldwide for simulating diverse systems ranging from biomembranes to explosives (RDX) at atomistic level of detail. The sub-femtosecond time-steps associated with ReaxFF strongly motivate significant improvements to per-timestep simulation time through effective use of GPUs. This paper presents, in detail, the design and implementation of PuReMD-GPU, which enables ReaxFF simulations on GPUs, as well as various performance optimization techniques we developed to obtain high performance on state-of-the-art hardware. Comprehensive experiments on model systems (bulk water and amorphous silica) are presented to quantify the performance improvements achieved by PuReMD-GPU and to verify its accuracy. In particular, our experiments show up to 16× improvement in runtime compared to our highly optimized CPU-only single-core ReaxFF implementation. PuReMD-GPU is a unique production code, and is currently available on request from the authors

PuReMD-GPU: A reactive molecular dynamics simulation package for GPUs

Energy Technology Data Exchange (ETDEWEB)

Kylasa, S.B., E-mail: skylasa@purdue.edu [Department of Elec. and Comp. Eng., Purdue University, West Lafayette, IN 47907 (United States); Aktulga, H.M., E-mail: hmaktulga@lbl.gov [Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, MS 50F-1650, Berkeley, CA 94720 (United States); Grama, A.Y., E-mail: ayg@cs.purdue.edu [Department of Computer Science, Purdue University, West Lafayette, IN 47907 (United States)

2014-09-01

We present an efficient and highly accurate GP-GPU implementation of our community code, PuReMD, for reactive molecular dynamics simulations using the ReaxFF force field. PuReMD and its incorporation into LAMMPS (Reax/C) is used by a large number of research groups worldwide for simulating diverse systems ranging from biomembranes to explosives (RDX) at atomistic level of detail. The sub-femtosecond time-steps associated with ReaxFF strongly motivate significant improvements to per-timestep simulation time through effective use of GPUs. This paper presents, in detail, the design and implementation of PuReMD-GPU, which enables ReaxFF simulations on GPUs, as well as various performance optimization techniques we developed to obtain high performance on state-of-the-art hardware. Comprehensive experiments on model systems (bulk water and amorphous silica) are presented to quantify the performance improvements achieved by PuReMD-GPU and to verify its accuracy. In particular, our experiments show up to 16× improvement in runtime compared to our highly optimized CPU-only single-core ReaxFF implementation. PuReMD-GPU is a unique production code, and is currently available on request from the authors.

Prokofiev: The Fiery Angel.Gösta Ohlin Vocal Ensemble / David J. Fanning

Index Scriptorium Estoniae

Fanning, David J.

1991-01-01

Uuest heliplaadist "Prokofiev: The Fiery Angel.Gösta Ohlin Vocal Ensemble, Gothenburg Pro Musica Chamber Choir and Symphony Orchestra, Neeme Järvi" DG CD 431 669-2 GH2 (two discs, nas:118 minutes:DDD)

Between Gods and Humans: Angels, demons and others

OpenAIRE

Piffzmann, Fabien; Römer, Thomas

2015-01-01

The interdisciplinary symposium “Between Gods and Humans: Angels, Demons and Others” was held on 19 and 20 May 2014, within the framework of the Chair of the Hebrew Bible and its Contexts’ seminar. Astaroth, illustration by Louis Breton This symposium was an opportunity once again to bring together Biblicists, Assyriologists, Egyptologists, Hellenists, an Iranologist, and a Medievalist, who were invited by Prof. Römer to examine the question of the intermediaries that inhabit the spaces betw...

MD#2183: Calibration of the IR6 B2 diamond BLMs

CERN Document Server

Valette, Matthieu; Lindstrom, Bjorn Hans Filip

2018-01-01

In case of an asynchronous beam dump with a fully filled LHC machine, causing ~40 bunches to impact on the movable dump protection absorber (TCDQ), it is expected that all standard ionisation chamber Beam Loss Monitors (IC BLM) around the LHC dumping region in IR6 will be saturated. Diamond Beam Loss Monitors (dBLM) were therefore installed next to the TCDQ downstream of the extraction kickers. These detectors allow resolving losses at a nanosecond timescale and with a dynamic range of several orders of magnitude; thus, allowing to derive the number of nominal bunches impacting the TCDQ. After a first series of calibrations using asynchronous beam dump tests, an experiment was conducted during MD#1182 to demonstrate the possibility of resolving a nominal bunch hitting the TCDQ. During this first MD only the Beam 1 dBLM was calibrated appropriately, a second calibration MD was therefore performed in 2017 for the B2 system. Results from this MD and conclusions regarding dBLM saturation with a top energy nominal...

MD2036: UFO Dynamics Studies and UFO Fast Detection

CERN Document Server

Belanger, Philippe; Valette, Matthieu; Lindstrom, Bjorn Hans Filip; Grob, Laura Katharina; Schmidt, Rudiger; Wollmann, Daniel

2017-01-01

UFOs are one of the remaining unknown related to LHC operation. Therefore, improving the understanding of UFO dynamics and validating the developed models against direct beam measurements is of fundamental importance in view of LHC operation at 7 TeV and with HL-LHC beam intensities. If not understood, UFOs could also be a showstopper for future machines such as FCC. This MD demonstrates new methods to study the dynamic behaviour of a calibrated UFO, simulated by the interaction of wire scanners with the beam. The events created during the MD were monitored using diamond BLMs in IR7, providing bunch-by-bunch resolution measurements. The analysis presented herein shows that blown-up bunches can be used to identify the plane of movement of UFOs, that bunch profiles and bunch sizes can be measured with dBLMs with good precision, that simulation of expected losses are in good agreement with measurements for oscillating bunches and that the space resolution of the acquisition system used during the MD is about 10 ...

MdATG18a overexpression improves tolerance to nitrogen deficiency and regulates anthocyanin accumulation through increased autophagy in transgenic apple.

Science.gov (United States)

Sun, Xun; Jia, Xin; Huo, Liuqing; Che, Runmin; Gong, Xiaoqing; Wang, Ping; Ma, Fengwang

2018-02-01

Nitrogen (N) availability is an essential factor for plant growth. Recycling and remobilization of N have strong impacts on crop yield and quality under N deficiency. Autophagy is a critical nutrient-recycling process that facilitates remobilization under starvation. We previously showed that an important AuTophaGy (ATG) protein from apple, MdATG18a, has a positive role in drought tolerance. In this study, we explored its biological role in response to low-N. Overexpression of MdATG18a in both Arabidopsis and apple improved tolerance to N-depletion and caused a greater accumulation of anthocyanin. The increased anthocyanin concentration in transgenic apple was possibly due to up-regulating flavonoid biosynthetic and regulatory genes (MdCHI, MdCHS, MdANS, MdPAL, MdUFGT, and MdMYB1) and higher soluble sugars concentration. MdATG18a overexpression enhanced starch degradation with up-regulating amylase gene (MdAM1) and up-regulated sugar metabolism related genes (MdSS1, MdHXKs, MdFK1, and MdNINVs). Furthermore, MdATG18a functioned in nitrate uptake and assimilation by up-regulating nitrate reductase MdNIA2 and 3 high-affinity nitrate transporters MdNRT2.1/2.4/2.5. MdATG18a overexpression also elevated other important MdATG genes expression and autophagosomes formation under N-depletion, which play key contributions to above changes. Together, these results demonstrate that overexpression of MdATG18a enhances tolerance to N-deficiencies and plays positive roles in anthocyanin biosynthesis through greater autophagic activity. © 2017 John Wiley & Sons Ltd.

STRATEGI PEMASARAN PUBLIC RELATIONS MD ENTERTAINMENT PADA PEMASARAN FILM HABIBIE & AINUN

OpenAIRE

Trisna Adi Permana; Lilis Puspitasari

2015-01-01

Tujuan penelitian ini adalah untuk mengetahui perencanaan, implementasi serta evaluasi dari strategi Marketing Public Relations yang ditetapkan PR MD Entertainment pada film Habibie & Ainun pada tahun 2012-2013. Metode yang dilakukan adalah metode deskriptif yang bertujuan melukiskan secara sistematis fakta atau karakteristik populasi tertentu atau bidang tertentu secara faktual dan cermat. Hasil penelitian menunjukan PR MD Entertainment telah melakukan tahapan-tahapan atau Teknik...

The rhetorical function of references to angels in the Main Letters of ...

African Journals Online (AJOL)

Test

2011-06-07

Jun 7, 2011 ... (1984:245–247), Morland (1995:148–149), Kremendahl (2000:83) and ..... gender-related roles that he links to creation (cf. dia; tou`to ..... Carr, W., 1981, Angels and principalities: The background, meaning and development.

33 CFR 110.214 - Los Angeles and Long Beach harbors, California.

Science.gov (United States)

2010-07-01

... Angeles Harbor). A circular area with a radius of 400 yards (approximately 366 meters), centered in... 400 Transportation Corridor. (C) Outer Harbor: The western boundary of Commercial Anchorage B. (2... Thence along a line described as an arc, radius of 460 meters (approximately 1509 feet) centered on 33...

MD 2179: Scraping of off-momentum halo after injection

CERN Document Server

Garcia Morales, Hector; Patecki, Marcin; Wretborn, Sven Joel; CERN. Geneva. ATS Department

2018-01-01

In this MD, a beam scraping was performed using the momentum primary collimator in IR3 where dispersion is high. A second scraping was performed using a TCSG in IR7 where dispersion is almost negligible. In such a way, we aim to disentangle the contribution of off-momentum particles to halo population. These scrapings will provide useful information to better understand the usual off-momentum losses we see at the start of the ramp. The MD results would also be used to benchmark simulations of off-momentum beam losses in order to gain confidence in simulation models.

InforMD: a new initiative to raise public awareness about breast density.

Science.gov (United States)

Hugo, Honor J; Zysk, Aneta; Dasari, Pallave; Britt, Kara; Hopper, John L; Stone, Jennifer; Thompson, Erik W; Ingman, Wendy V

2018-01-01

On a mammogram, breast density (also known as mammographic density) is shown as white and bright regions and is associated with reduced sensitivity in cancer detection and increased breast cancer risk. However, many Australian women are unaware of the significance of breast density as it is not routinely reported or discussed. In order to address this lack of knowledge, Australian breast cancer researchers with expertise in mammographic density formed the InforMD alliance (INformation FORum on Mammographic Density) in 2016. The alliance is working to raise awareness of breast density with the goal of improving breast cancer diagnosis and health outcomes for women. The InforMD website (www.InforMD.org.au) was launched in October 2016, coinciding with a major nationwide public awareness campaign by the alliance during breast cancer awareness month. The website contains unbiased, accurate, updated information on breast density. The website also provides summaries of major research articles in layperson language, recent news items related to breast density, links to relevant information for health professionals, events, and feature articles. Members of the public and health professionals can also subscribe for news updates. The interactive online Forum section facilitates discussion between health professionals, scientists and members of the public. To increase online traffic to the website, Facebook (www.facebook.com/BeInforMD) and Twitter (https://twitter.com/BeInforMD_) pages were launched in December 2016. Since its launch, InforMD has generated considerable interest. The public awareness campaign reached over 7 million Australians through a combination of newspaper, TV, radio, and online news. The website has attracted 13,058 unique visitors and 30,353 page views (data as of 19/12/2017). Breast cancer researchers have a significant role to play in disseminating information to the public on breast density. A combination of mainstream and social media, together with

Diet and Obesity in Los Angeles County 2007–2012: Is there a measurable effect of the 2008 “Fast-Food Ban”?

OpenAIRE

Sturm, Roland; Hattori, Aiko

2015-01-01

We evaluate the impact of “Los Angeles Fast-Food Ban”, a zoning regulation that restricts opening/remodeling of standalone fast-food restaurants in South Los Angeles since 2008. Food retail permits issued after the ban are more often for small food/convenience stores and less often for larger restaurants not part of a chain in South Los Angeles compared to other areas; there are no significant differences in the share of new fast-food chain outlets, other chain restaurants, or large food mark...

An apple B-box protein, MdCOL11, is involved in UV-B- and temperature-induced anthocyanin biosynthesis.

Science.gov (United States)

Bai, Songling; Saito, Takanori; Honda, Chikako; Hatsuyama, Yoshimichi; Ito, Akiko; Moriguchi, Takaya

2014-11-01

Our studies showed that an apple B-box protein, MdCOL11, the homolog of AtBBX22, is involved in UV-B- and temperature-induced anthocyanin biosynthesis in apple peel. Anthocyanin is responsible for the red pigmentation in apple peel and a R2R3 MYB gene, MdMYBA/1/10, a homolog of MdMYBA, controls its accumulation. Arabidopsis PAP1 is under the control of a series of upstream factors involved in light signal transduction and photomorphogenesis, such as ELONGATED HYPOCOTYL 5 (HY5) and B-box family (BBX) proteins. In this study, we identified and characterized the homolog of Arabidopsis BBX22 in apple, designated as MdCOL11. Overexpression of MdCOL11 in Arabidopsis enhanced the accumulation of anthocyanin. In apples, MdCOL11 was differentially expressed in all tissues, with the highest expression in petals and the lowest expression in the xylem. Transcripts of MdCOL11 noticeably accumulated at the ripening stage, concomitant with increases in the expressions of anthocyanin biosynthesis-related genes. In an in vitro treatment experiment, MdCOL11 was upregulated in an ultra-violet (UV)-B- and temperature-dependent manner, together with the inductions of anthocyanin biosynthesis-related genes and anthocyanin accumulation in apple peel. Furthermore, a dual-luciferase assay indicated that (1) MdCOL11 regulated the expression of MdMYBA and (2) MdCOL11 was a target of MdHY5. Taken together, our results suggest that MdCOL11 is involved in MdHY5-mediated signal transduction and regulates anthocyanin accumulation in apple peel, which sheds new light on anthocyanin accumulation in apples.

Public Perceptions of Tsunamis and the NOAA TsunamiReady Program in Los Angeles

Science.gov (United States)

Rosati, A.

2010-12-01

After the devastating December 2004 Indian Ocean Tsunami, California and other coastal states began installing "Tsunami Warning Zone" and "Evacuation Route" signs at beaches and major access roads. The geography of the Los Angeles area may not be conducive to signage alone for communication of the tsunami risk and safety precautions. Over a year after installation, most people surveyed did not know about or recognize the tsunami signs. More alarming is that many did not believe a tsunami could occur in the area even though earthquake generated waves have reached nearby beaches as recently as September 2009! UPDATE: FEB. 2010. Fifty two percent of the 147 people surveyed did not believe they would survive a natural disaster in Los Angeles. Given the unique geography of Los Angeles, how can the city and county improve the mental health of its citizens before and after a natural disaster? This poster begins to address the issues of community self-efficacy and resiliency in the face of tsunamis. Of note for future research, the data from this survey showed that most people believed climate change would increase the occurrence of tsunamis. Also, the public understanding of water inundation was disturbingly low. As scientists, it is important to understand the big picture of our research - how it is ultimately communicated, understood, and used by the public.

Strategi Pemasaran Public Relations Md Entertainment Pada Pemasaran Film Habibie & Ainun

OpenAIRE

Permana, Trisna Adi; Puspitasari, Lilis

2015-01-01

Tujuan penelitian ini adalah untuk mengetahui perencanaan, implementasi serta evaluasi dari strategiMarketing Public Relations yang ditetapkan PR MD Entertainment pada film Habibie & Ainun pada tahun2012-2013. Metode yang dilakukan adalah metode deskriptif yang bertujuan melukiskan secara sistematisfakta atau karakteristik populasi tertentu atau bidang tertentu secara faktual dan cermat. Hasil penelitianmenunjukan PR MD Entertainment telah melakukan tahapan-tahapan atau Teknik PR pada film Ha...

Automating the Technical Library at Los Angeles' Department of Information Systems.

Science.gov (United States)

Gillette, Robert

1992-01-01

Description of the automation of the technical library of the City of Los Angeles Department of Information Services provides background information on the department and its library; lists the automation project goals and objectives; and describes the two software programs--ObjectVision and Paradox Engine--used as applications development tools…

Micropigmentation for Vitiligo

Science.gov (United States)

... E. Grimes, MD - Los Angeles, California Micropigmentation for Vitiligo Micropigmentation involves implanting small particles of natural pigment ... Keloid formation MRI complications Why choose micropigmentation for vitiligo Micropigmentation can: Help blend the color of vitiligo ...

Starting school healthy and ready to learn: using social indicators to improve school readiness in Los Angeles County.

Science.gov (United States)

Wold, Cheryl; Nicholas, Will

2007-10-01

School readiness is an important public health outcome, determined by a set of interdependent health and developmental trajectories and influenced by a child's family, school, and community environments. The same factors that influence school readiness also influence educational success and health throughout life. A California cigarette tax ballot initiative (Proposition 10) created new resources for children aged 0 to 5 years and their families statewide through county-level First 5 commissions, including First 5 LA in Los Angeles County. An opportunity to define and promote school readiness indicators was facilitated by collaborative relationships with a strong emphasis on data among First 5 LA, the Children's Planning Council, and the Los Angeles County Public Health Department, and other child-serving organizations. A workgroup developed school readiness goals and indicators based on recommendations of the National Education Goals Panel and five key domains of child well-being: 1) good health, 2) safety and survival, 3) economic well-being, 4) social and emotional well-being, and 5) education/workforce readiness. The Los Angeles County Board of Supervisors and First 5 LA Commission adopted the school readiness indicators. First 5 LA incorporated the indicators into the results-based accountability framework for its strategic plan and developed a community-oriented report designed to educate and spur school readiness-oriented action. The Los Angeles County Board of Supervisors approved a countywide consensus-building plan designed to engage key stakeholders in the use of the indicators for planning, evaluation, and community-building activities. School readiness indicators in Los Angeles County represent an important step forward for public health practice, namely, the successful blending of an expanded role for assessment with the ecological model.

Remote Sensing of Spatial Distributions of Greenhouse Gases in the Los Angeles Basin

Science.gov (United States)

Fu, Dejian; Sander, Stanley P.; Pongetti, Thomas J.; Cheung, Ross; Stutz, Jochen

2010-01-01

The Los Angeles air basin is a significant anthropogenic source of greenhouse gasses and pollutants including CO2, CH4, N2O, and CO, contributing significantly to regional and global climate change. Recent legislation in California, the California Global Warning Solutions Act (AB32), established a statewide cap for greenhouse gas emissions for 2020 based on 1990 emissions. Verifying the effectiveness of regional greenhouse gas emissions controls requires high-precision, regional-scale measurement methods combined with models that capture the principal anthropogenic and biogenic sources and sinks. We present a novel approach for monitoring the spatial distribution of greenhouse gases in the Los Angeles basin using high resolution remote sensing spectroscopy. We participated in the CalNex 2010 campaign to provide greenhouse gas distributions for comparison between top-down and bottom-up emission estimates.

Preventing the repetition: Or, what Los Angeles' experience in water management can teach Atlanta about urban water disputes

Science.gov (United States)

Feldman, David L.

2009-04-01

Southern California's water history is an epic story with larger-than-life characters and ambitions and abundant hubris. Students of water policy might reasonably ask: Does this story, while unique to greater Los Angeles, hold lessons for other metropolises experiencing water conflict caused by explosive growth? We examine this question by considering similarities between the challenges facing Atlanta, Georgia, one of the nation's fastest growing cities in the 21st century, with those of Los Angeles. We focus on junctures where important decisions regarding water were made and how these decisions continue to challenge both cities' futures. Atlanta's financial, cultural, and environmental imprint on its surrounding region share remarkable similarities with Los Angeles' influence trajectory: it is the largest city in the southeast, a principal transportation and business hub, and it is embroiled in water conflict with nearby communities and adjoining states.

Transaction Costs: Valuation Disputes, Bi-Lateral Monopoly Bargaining and Third-Party Effects in Water Rights Exchanges. The Owens Valley Transfer to Los Angeles

OpenAIRE

Gary D. Libecap

2004-01-01

Between 1905 and 1934 over 869 farmers in Owens Valley, California sold their land and associated water rights to Los Angeles, 250 miles to the southwest. This agriculture-to-urban water transfer increased Los Angeles' water supply by over 4 times, making the subsequent dramatic growth of the semi-arid city possible, generating large economic returns. The exchange took water from a marginal agricultural area and transferred it via the Los Angeles Aqueduct. No other sources of water became ava...

Angiotensin II induces kidney inflammatory injury and fibrosis through binding to myeloid differentiation protein-2 (MD2).

Science.gov (United States)

Xu, Zheng; Li, Weixin; Han, Jibo; Zou, Chunpeng; Huang, Weijian; Yu, Weihui; Shan, Xiaoou; Lum, Hazel; Li, Xiaokun; Liang, Guang

2017-03-21

Growing evidence indicates that angiotensin II (Ang II), a potent biologically active product of RAS, is a key regulator of renal inflammation and fibrosis. In this study, we tested the hypothesis that Ang II induces renal inflammatory injury and fibrosis through interaction with myeloid differentiation protein-2 (MD2), the accessory protein of toll-like receptor 4 (TLR4) of the immune system. Results indicated that in MD2 -/- mice, the Ang II-induced renal fibrosis, inflammation and kidney dysfunction were significantly reduced compared to control Ang II-infused wild-type mice. Similarly, in the presence of small molecule MD2 specific inhibitor L6H21 or siRNA-MD2, the Ang II-induced increases of pro-fibrotic and pro-inflammatory molecules were prevented in tubular NRK-52E cells. MD2 blockade also inhibited activation of NF-κB and ERK. Moreover, MD2 blockade prevented the Ang II-stimulated formation of the MD2/TLR4/MyD88 signaling complex, as well as the increased surface binding of Ang II in NRK-52E cells. In addition, Ang II directly bound recombinant MD2 protein, rather than TLR4 protein. We conclude that MD2 is a significant contributor in the Ang II-induced kidney inflammatory injury in chronic renal diseases. Furthermore, MD2 inhibition could be a new and important therapeutic strategy for preventing progression of chronic renal diseases.

Image fusion in craniofacial virtual reality modeling based on CT and 3dMD photogrammetry.

Science.gov (United States)

Xin, Pengfei; Yu, Hongbo; Cheng, Huanchong; Shen, Shunyao; Shen, Steve G F

2013-09-01

The aim of this study was to demonstrate the feasibility of building a craniofacial virtual reality model by image fusion of 3-dimensional (3D) CT models and 3 dMD stereophotogrammetric facial surface. A CT scan and stereophotography were performed. The 3D CT models were reconstructed by Materialise Mimics software, and the stereophotogrammetric facial surface was reconstructed by 3 dMD patient software. All 3D CT models were exported as Stereo Lithography file format, and the 3 dMD model was exported as Virtual Reality Modeling Language file format. Image registration and fusion were performed in Mimics software. Genetic algorithm was used for precise image fusion alignment with minimum error. The 3D CT models and the 3 dMD stereophotogrammetric facial surface were finally merged into a single file and displayed using Deep Exploration software. Errors between the CT soft tissue model and 3 dMD facial surface were also analyzed. Virtual model based on CT-3 dMD image fusion clearly showed the photorealistic face and bone structures. Image registration errors in virtual face are mainly located in bilateral cheeks and eyeballs, and the errors are more than 1.5 mm. However, the image fusion of whole point cloud sets of CT and 3 dMD is acceptable with a minimum error that is less than 1 mm. The ease of use and high reliability of CT-3 dMD image fusion allows the 3D virtual head to be an accurate, realistic, and widespread tool, and has a great benefit to virtual face model.

The unauthorized Mexican immigrant population and welfare in Los Angeles County: a comparative statistical analysis.

Science.gov (United States)

Marcelli, E A; Heer, D M

1998-01-01

"Using a unique 1994 Los Angeles County Household Survey of foreign-born Mexicans and the March 1994 and 1995 Current Population Surveys, we estimate the number of unauthorized Mexican immigrants (UMIs) residing in Los Angeles County, and compare their use of seven welfare programs with that of other non-U.S. citizens and U.S. citizens. Non-U.S. citizens were found to be no more likely than U.S. citizens to have used welfare, and UMIs were 11% (14%) less likely than other non-citizens (U.S.-born citizens).... We demonstrate how results differ depending on the unit of analysis employed, and on which programs constitute ¿welfare'." excerpt

StandsSIM-MD: a Management Driven forest SIMulator

Directory of Open Access Journals (Sweden)

Susana Barreiro

2016-07-01

Full Text Available Aim of the study: The existing stand level forest simulators available in Portugal were not developed with the aim of including up-to-date model versions and were limited in terms of accounting for forest management. The simulators’ platform, sIMfLOR was recently created to implement different growth models with a common philosophy. The objective was developing one easily-updatable, user-friendly, forest management and climate change sensitive simulator capable of projecting growth for the main tree species in Portugal. Area of the study: Portugal. Material and methods: The new simulator was programmed in a modular form consisting of several modules. The growth module integrates different forest growth and yield models (empirical and process-based for the main wood production tree species in Portugal (eucalypt, umbrella and maritime pines; whereas the management module drives the growth projections along the planning horizon according to a range of forest management approaches and climate (at present only available for eucalypt. Main results: The main result is the StandsSIM-MD Management Driven simulator that overcomes the limitations of the existing stand level simulators. It is a step forward when compared to the models currently available in the sIMfLOR platform covering more tree species, stand structures and stand compositions. It is focused on end-users and it is based on similar concepts regarding the generation of required inputs and generated outputs. Research highlights: -          Forest Management Driven simulations approach -          Multiple Prescriptions-Per-Stand functionality -          StandsSIM-MD can be used to support landowners decisions on stand forest management -          StandsSIM-MD simulations at regional level can be combined with optimization routines Keywords: Forest simulator, Forest Management Approaches; StandsSIM-MD; forest management.

Behavioral Criteria in Research and the Study of Racism: Performing the Jackal Function. Part I.

Science.gov (United States)

1979-01-01

Legrande Clegg Attorney at Law /Historian Los Angeles, Ca. Price Cobbs, M.D. Director, Pacific Management Systems, San Francisco, Ca. John Collier...Angeles, Ca. Joseph T. Klapper, Ph.D. C. B. S. Social Research I ill Charles Lawrence, J.D. College of Law , University of San Francisco, Ca. Lee C. Lee...beliefs of the people who use it. 7. S. Szasz 70" CHAPTER IV The Historical Background and Theoretical Model for the Study of Racist Belief-Behavior and

Heavy Metals (Cu, Pb and Cd) in Water and Angel Fish (Chelmon rostractus) from Batam Coastal, Indonesia

OpenAIRE

Ismarti Ismarti; Ramses Ramses; Suheryanto Suheryanto; Fitrah Amelia

2017-01-01

Fish play an important role in human nutrition and therefore need to be carefully and routinely monitored to ensure that there are no high levels of heavy metals being transferred to human through their consumption. This study has been carried out to determine level of heavy metals (Cu, Pb, and Cd) in water and angel fish, Chelmon rostractus collected from coast of Batam. We report levels of Cu, Cd and Pb in water and angel fish from Coast Batam using Atomic Absorption Spectroscopy (AAS). Lev...

The Work Experience of Undocumented Mexican Women Migrants in Los Angeles.

Science.gov (United States)

Simon, Rita J.; DeLey, Margo

1984-01-01

Undocumented Mexican women workers in Los Angeles were interviewed about their work experience in the United States. Most of them work in factories, not in domestic service. Most earn a salary above minimum wage but below that earned by documented women, and 80 percent believe their treatment at work equals that of other workers. (KH)

An unusual dimeric structure and assembly for TLR4 regulator RP105-MD-1

Energy Technology Data Exchange (ETDEWEB)

Yoon, Sung-il; Hong, Minsun; Wilson, Ian A [Scripps

2011-11-16

RP105-MD-1 modulates the TLR4-MD-2-mediated, innate immune response against bacterial lipopolysaccharide (LPS). The crystal structure of the bovine 1:1 RP105-MD-1 complex bound to a putative endogenous lipid at 2.9 Å resolution shares a similar overall architecture to its homolog TLR4-MD-2 but assembles into an unusual 2:2 homodimer that differs from any other known TLR-ligand assembly. The homodimer is assembled in a head-to-head orientation that juxtaposes the N-terminal leucine-rich repeats (LRRs) of the two RP105 chains, rather than the usual tail-to-tail configuration of C-terminal LRRs in ligand-activated TLR dimers, such as TLR1-TRL2, TLR2-TLR6, TLR3-TLR3 and TLR4-TLR4. Another unusual interaction is mediated by an RP105-specific asparagine-linked glycan, which wedges MD-1 into the co-receptor binding concavity on RP105. This unique mode of assembly represents a new paradigm for TLR complexes and suggests a molecular mechanism for regulating LPS responses.

Signature of the Joint Declaration by the Minor Academy of Science of Ukraine and CERN concerning participation by Ukrainian teachers and students in educational programmes at CERN

CERN Multimedia

Hoch, Michael

2011-01-01

Signature of the Joint Declaration by the Minor Academy of Science of Ukraine and CERN concerning participation by Ukrainian teachers and students in educational programmes at CERN The signatories: Dr Rolf Landua Education Group Leader Professor Stanislav Dovgyi President of the Minor Academy of Science of Ukraine On the photos: Mick Storr, Marina Savino, Rolf Landua, Stanislav Dovgyi, Tetiana Hryn'Ova

Find an Orthopaedic Foot and Ankle MD/DO

Science.gov (United States)

... All Site Content AOFAS / FootCareMD / Find a Surgeon Find a Foot & Ankle Orthopaedic Surgeon Page Content Who ... your prescribed treatment (surgical and/or non-surgical) ​ Find a Surgeon ​ Click here to find a foot ...

Molecular cloning and functional analysis of a blue light receptor gene MdCRY2 from apple (Malus domestica).

Science.gov (United States)

Li, Yuan-Yuan; Mao, Ke; Zhao, Cheng; Zhao, Xian-Yan; Zhang, Rui-Fen; Zhang, Hua-Lei; Shu, Huai-Rui; Hao, Yu-Jin

2013-04-01

MdCRY2 was isolated from apple fruit skin, and its function was analyzed in MdCRY2 transgenic Arabidopsis. The interaction between MdCRY2 and AtCOP1 was found by yeast two-hybrid and BiFC assays. Cryptochromes are blue/ultraviolet-A (UV-A) light receptors involved in regulating various aspects of plant growth and development. Investigations of the structure and functions of cryptochromes in plants have largely focused on Arabidopsis (Arabidopsis thaliana), tomato (Solanum lycopersicum), pea (Pisum sativum), and rice (Oryza sativa). However, no data on the function of CRY2 are available in woody plants. In this study, we isolated a cryptochrome gene, MdCRY2, from apple (Malus domestica). The deduced amino acid sequences of MdCRY2 contain the conserved N-terminal photolyase-related domain and the flavin adenine dinucleotide (FAD) binding domain, as well as the C-terminal DQXVP-acidic-STAES (DAS) domain. Relationship analysis indicates that MdCRY2 shows the highest similarity to the strawberry FvCRY protein. The expression of MdCRY2 is induced by blue/UV-A light, which represents a 48-h circadian rhythm. To investigate the function of MdCRY2, we overexpressed the MdCRY2 gene in a cry2 mutant and wild type (WT) Arabidopsis, assessed the phenotypes of the resulting transgenic plants, and found that MdCRY2 functions to regulate hypocotyl elongation, root growth, flower initiation, and anthocyanin accumulation. Furthermore, we examined the interaction between MdCRY2 and AtCOP1 using a yeast two-hybrid assay and a bimolecular fluorescence complementation assay. These data provide functional evidence for a role of blue/UV-A light-induced MdCRY2 in controlling photomorphogenesis in apple.

Diet and obesity in Los Angeles County 2007-2012: Is there a measurable effect of the 2008 "Fast-Food Ban"?

Science.gov (United States)

Sturm, Roland; Hattori, Aiko

2015-05-01

We evaluate the impact of the "Los Angeles Fast-Food Ban", a zoning regulation that has restricted opening/remodeling of standalone fast-food restaurants in South Los Angeles since 2008. Food retail permits issued after the ban are more often for small food/convenience stores and less often for larger restaurants not part of a chain in South Los Angeles compared to other areas; there are no significant differences in the share of new fast-food chain outlets, other chain restaurants, or large food markets. About 10% of food outlets are new since the regulation, but there is little evidence that the composition has changed differentially across areas. Data from the California Health Interview Survey show that fast-food consumption and overweight/obesity rates have increased from 2007 to 2011/2012 in all areas. The increase in the combined prevalence of overweight and obesity since the ban has been significantly larger in South Los Angeles than elsewhere. A positive development has been a drop in soft drink consumption since 2007, but that drop is of similar magnitude in all areas. Copyright © 2015 Elsevier Ltd. All rights reserved.

MD2725: 16L2 aperture measurement

CERN Document Server

Mirarchi, Daniele; Rossi, Roberto; CERN. Geneva. ATS Department

2018-01-01

Dumps induced by sudden increase of losses in the half-cell 16L2 have been a serious machine limitation during the 2017 run. The aim of this MD was to perform local aperture measurements in order to assess differences after the beam screen regeneration, compared to first measurements in 2017.

Possibilities of production of neutron-rich Md isotopes in multi-nucleon transfer reactions

Energy Technology Data Exchange (ETDEWEB)

Mun, Myeong-Hwan; Lee, Young-Ouk [Korea Atomic Energy Research Institue, Daejeon (Korea, Republic of); Adamian, G.G.; Antonenko, N.V. [Joint Institute for Nuclear Research, Dubna (Russian Federation)

2016-12-15

The possibilities of production of yet unknown neutron-rich isotopes of Md are explored in several multi-nucleon transfer reactions with actinide targets and stable and radioactive beams. The projectile-target combinations and bombarding energies are suggested to produce new neutron-rich isotopes of Md in future experiments. (orig.)

Contested Campuses: Politics, race, and the battles over public education in the Greater Los Angeles Area, 1949-1972

OpenAIRE

Kovalesky, Brian Robert

2017-01-01

In the late 1950s and early 1960s, during the height of protests and actions by civil rights activists against de facto school segregation in the Los Angeles area, the residents of a group of small cities fought to break away from the Los Angeles City Schools and create a new, independent school district. If established, the district would serve white pupils nearly exclusively, preserving and reinforcing racially segregated schools in the area. Proponents of the plan were residents of the maj...

Water at silica/liquid water interfaces investigated by DFT-MD simulations

Science.gov (United States)

Gaigeot, Marie-Pierre

This talk is dedicated to probing the microscopic structural organization of water at silica/liquid water interfaces including electrolytes by first principles DFT-based molecular dynamics simulations (DFT-MD). We will present our very recent DFT-MD simulations of electrolytic (KCl, NaCl, NaI) silica/liquid water interfaces in order to unravel the intertwined structural properties of water and electrolytes at the crystalline quartz/liquid water and amorphous silica/liquid water interfaces. DFT-MD simulations provide direct knowledge of the structural organization of water and the H-Bond network formed between the water molecules within the different water layers above the silica surface. One can furthermore extract vibrational signatures of the water molecules within the interfacial layers from the DFT-MD simulations, especially non-linear SFG (Sum Frequency generation) signatures that are active at solid/liquid interfaces. The strength of the simulated spectra is that a detailed analysis of the signatures in terms of the water/water H-Bond networks formed within the interfacial water layers and in terms of the water/silica or water/electrolytes H-Bond networks can be given. Comparisons of SFG spectra between quartz/water/electrolytes and amorphous silica/water/electrolytes interfaces allow us to definitely conclude on how the structural arrangements of liquid water at these electrolytic interfaces modulate the final spectroscopic signatures. Invited speaker.

Geomorphology and petrography of the Angeles lava flow and the Monte de la Cruz cinder cone, Barva Volcano, Costa Rica

International Nuclear Information System (INIS)

Rojas, Vanessa; Barahona, Dione; Alvarado, Guillermo E

2017-01-01

A geomorphological and pretrographic study was carried out at the lava flow Angeles and the Monte de la Cruz cone in the foothills of the Volcan Barva in Costa Rica. The 1967 aerial photographs at scale 1: 17,000 and 1: 13,000, 1992 at scale 1: 60,000 and TERRA 1997 at scale 1: 40,000 were used for the photogeological study, supplemented with the analysis of the eastern sector of the Hoja Topografica Barva (1: 50 000) of the Instituto Geografico Nacional (IGN) and other topographic maps at different scales (1: 25 000 and 1: 10 000), in addition to the digital elevation models developed through Sistemas de Informacion Geografica (SIG). The information extracted from the wells of the Sistema Nacional de Aguas Subterraneas, Riego y Avenamiento (SENARA) for underground control was reinterpreted. In the field work thicknesses were measured and an estimation of the volumes, dimensions of the cast and other associated geoforms was made. Likewise, 9 samples of rock were selected for the elaboration of thin sections and for their respective petrographic analysis, which allowed to define the main lava flow units and their possible flows. As a result of the volcanic activity of the cone, two flow units of the Angeles wash were identified, the Lower Angels unit and the Superior Angels unit. Petrographically, Angeles Inferior was reciprocated with an andesitic vesical basaltic lava with a porphyritic to slightly glomeroporphyric hypocrystalline texture, with plagioclase, clinopyroxene, orthopyroxene, olivine and opaque phenocrysts. On the other hand, Superior Angeles has been vesicular andesitic with a hypocrystalline texture, glomeroporfiritica to serial glomeroporfiritica, with plagioclase, clinopyroxene, orthopyroxene, olivine and opaque phenocrysts. Morphologically, kipukas and levees were observed. Regionally, it was observed that the Monte de la Cruz cone, along with other smaller satellite cones, are aligned N19 O W along 8.5 km, evidencing an origin associated with a

Seeking solace in West Hollywood: sexual orientation-based hate crimes in Los Angeles County.

Science.gov (United States)

Stotzer, Rebecca L

2010-01-01

Many thriving "gay communities" across the United States report high levels of sexual orientation-based hate crimes every year, raising questions about the level of safety in these gay communities and neighborhoods. This study examines hate crime data from 2002-2006 in Los Angeles County and the relationship those hate crimes have to West Hollywood, the best known gay community of Los Angeles County. Results suggest that although West Hollywood does consistently report high numbers of hate crimes, this does not reflect a greatly increased risk to any one lesbian, gay, or bisexual person. Results suggest that we need to consider other variables as predictors (such as poverty, business density, and population density) in determining safe versus unsafe space, rather than just the percentage of lesbians, gay, and bisexuals in a population.

Usefulness of multidetector-row computed tomography (MD-CT) for diagnosis and evaluation of cardiovascular anomalies in infants

International Nuclear Information System (INIS)

Kani, Hiroyuki; Narabayashi, Isamu; Tanikake, Masato; Matsuki, Mitsuru; Uesugi, Yasuo

2005-01-01

We examined the effectiveness of multidetector-row CT (MD-CT) in the diagnosis and evaluation of cardiovascular anomalies in infants. MD-CT was performed 34 times on 21 patients with cardiovascular anomalies. We performed three evaluations: 1) The assessment of the specificity of MD-CT in detecting the morphological features of cardiovascular anomalies. 2) The diameters of aortae with coronary artery (CoA), and the diameters of pulmonary artery, measured by using MD-CT were compared with those by angiography. 3) The amount of exposure to radiation was measured. 1) MD-CT can detect CoA, pulmonary arteriovenous anomalies among extracardiac anomalies in all the patients. The diagnostic accuracy for intracardiac anomalies was poor as only six of the 15 anomalies could be accurately diagnosed. 2) The diameters of aortae and pulmonary artery obtained using MD-CT showed a good correlation with those obtained using arteriography (r=0.97, 0.95). 3) The average dose-length product was 269.2 mGy·cm. And the average effective dose was 5.1 mSv. MD-CT is not suitable for the evaluation of intracardiac anomalies, but is extremely effective in the evaluation of extracardiac major vascular anomalies. On the basis of the amount of information and noninvasive nature, MD-CT should be used first before angiography. (author)

An assessment of communication skills of the MD/MS students of institute of medicine in Nepal

Directory of Open Access Journals (Sweden)

Jagdish Prasad Agrawal

2013-09-01

Full Text Available Introduction The main objective of this study was to assess the level of interpersonal communication skills of MD/MS resident doctors and to provide recommendations for the future. Methods Descriptive, cross sectional, qualitative and quantitative research design was used. 7- point Likert scale (0 to 6 MAAS-Global scoring instrument was used. The subjects of the research were the MD/MS residents from various departments of Maharajgunj Medical Campus (MMC of Institute of Medicine, Maharajgunj, Kathmandu. Out of 162 MD/MS residents, only 30 (18.5% MD/MS residents were selected for the sample size for the study from 1st, 2nd and 3rd year. One MD/MS resident was required four video recording to conduct four interviews with patients coming to the outpatient department. Results There was high degree of positive correlation between Information sharing and Management (r=0.746 whereas weak negative correlation on clarification and diagnosis (r=-0.011. Inter-rater correlation was established before hand and was satisfactory (p < 0.05. Conclusions This base line study of MD/MS residents shows that over all MD/MS residents are deficient in almost all the components of interpersonal communication skills. A communication skills training course in postgraduate medical education could improve the existing communication skills of the doctors in Nepal.

Hybrid Pressure Retarded Osmosis−Membrane Distillation (PRO−MD) Process for Osmotic Power and Clean Water Generation

KAUST Repository

Han, Gang

2015-05-20

A novel pressure retarded osmosis−membrane distillation (PRO−MD) hybrid process has been experimentally conceived for sustainable production of renewable osmotic power and clean water from various waters. The proposed PRO−MD system may possess unique advantages of high water recovery rate, huge osmotic power generation, well controlled membrane fouling, and minimal environmental impacts. Experimental results show that the PRO−MD hybrid process is promising that not only can harvest osmotic energy from freshwater but also from wastewater. When employing a 2 M NaCl MD concentrate as the draw solution, ultrahigh power densities of 31.0 W/m2 and 9.3 W/m2 have been demonstrated by the PRO subsystem using deionized water and real wastewater brine as the feeds, respectively. Simultaneously, high purity potable water with a flux of 32.5−63.1 L/(m2.h) can be produced by the MD subsystem at 40−60 °C without any detrimental effects of fouling. The energy consumption in the MD subsystem might be further reduced by applying a heat exchanger in the hybrid system and using low-grade heat or solar energy to heat up the feed solution. The newly developed PRO−MD hybrid process would provide insightful guidelines for the exploration of alternative green technologies for renewable osmotic energy and clean water production.

Overexpression of a repressor MdMYB15L negatively regulates anthocyanin and cold tolerance in red-fleshed callus.

Science.gov (United States)

Xu, Haifeng; Yang, Guanxian; Zhang, Jing; Wang, Yicheng; Zhang, Tianliang; Wang, Nan; Jiang, Shenghui; Zhang, Zongying; Chen, Xuesen

2018-04-14

The cold-induced metabolic pathway and anthocyanin biosynthesis play important roles in plant growth. In this study, we identified a bHLH binding motif in the MdMYB15L protein using protein sequence analyses. Yeast two-hybrid and pull-down assays showed that MdMYB15L could interact with MdbHLH33. Overexpressing MdMYB15L in red-fleshed callus inhibited the expression of MdCBF2 and resulted in reduced cold tolerance but did not affect anthocyanin levels. Chip-PCR and EMSA analysis showed that MdMYB15L could bind the type II cis-acting element found in the MdCBF2 promoter. Overexpressing MdMYB15L in red-fleshed callus overexpressing MdbHLH33 also reduced cold tolerance and reduced MdbHLH33-induced anthocyanin biosynthesis. Knocking out the bHLH binding sequence of MdMYB15L (LBSMdMYB15L) prevented LBSMdMYB15L from interacting with MdbHLH33. Overexpressing LBSMdMYB15L in red-fleshed callus overexpressing MdbHLH33 also reduced cold tolerance and reduced MdbHLH33-induced anthocyanin biosynthesis. Together, these results suggested that an apple repressor MdMYB15L might play a key role in the cold signaling and anthocyanin metabolic pathways. Copyright © 2018 Elsevier Inc. All rights reserved.

Age and isotopic systematics of Cretaceous borehole and surface samples from the greater Los Angeles Basin region: Implications for the types of crust that might underlie Los Angeles and their distribution along late Cenozoic fault systems

Science.gov (United States)

Premo, Wayne R.; Morton, Douglas M.; Kistler, Ronald W.

2014-01-01

Nine U-Pb zircon ages were determined on plutonic rocks sampled from surface outcrops and rock chips of drill core from boreholes within the greater Los Angeles Basin region. In addition, lead-strontium-neodymium (Pb-Sr-Nd) whole-rock isotopic data were obtained for eight of these samples. These results help to characterize the crystalline basement rocks hidden in the subsurface and provide information that bears on the tectonic history of the myriad of fault systems that have dissected the Los Angeles region over the past 15 m.y. Seven of the nine samples have U-Pb ages ranging from 115 to 103 Ma and whole-rock Pb-Sr-Nd isotopic characteristics that indicate the crystalline basement underneath the greater Los Angeles Basin region is mostly part of the Peninsular Ranges batholith. Furthermore, these data are interpreted as evidence for (1) the juxtaposition of mid-Cretaceous, northern Peninsular Ranges batholith plutonic rocks against Late Cretaceous plutonic rocks of the Transverse Ranges in the San Fernando Valley, probably along the Verdugo fault; (2) the juxtaposition of older northwestern Peninsular Ranges batholith rocks against younger northeastern Peninsular Ranges batholith rocks in the northern Puente Hills, implying transposition of northeastern Peninsular Ranges batholith rocks to the west along unrecognized faults beneath the Chino Basin; and (3) juxtaposition of northern Peninsular Ranges batholith plutonic rocks against Late Cretaceous plutonic rocks of the Transverse Ranges along the San Jose fault in the northern San Jose Hills at Ganesha Park. These mainly left-lateral strike-slip faults of the eastern part of the greater Los Angeles Basin region could be the result of block rotation within the adjacent orthogonal, right-lateral, Elsinore-Whittier fault zone to the west and the subparallel San Jacinto fault zone to the east. The San Andreas fault system is the larger, subparallel, driving force further to the east.

The Slow-Growing Orange, A Demographer’s Look at Future Los Angeles,

Science.gov (United States)

1984-04-01

and even some downtown Los Angeles neighborhoods, through " gentrification "--will grow rapidly at the expense of others. A second dramatic aspect of...shores. Modern developments in commuaications and transportation, which have enabled us to expand trade with Asia and Latin America, have also

Amniotic Fluid Soluble Myeloid Differentiation-2 (sMD-2) as Regulator of Intra-amniotic Inflammation in Infection-induced Preterm Birth.

Science.gov (United States)

Dulay, Antonette T; Buhimschi, Catalin S; Zhao, Guomao; Oliver, Emily A; Abdel-Razeq, Sonya S; Shook, Lydia L; Bahtiyar, Mert O; Buhimschi, Irina A

2015-06-01

TLR4 mediates host responses to pathogens through a mechanism that involves protein myeloid differentiation-2 (MD-2) and its soluble form sMD-2. The role of sMD2 in intra-amniotic inflammation-induced preterm birth has not been previously explored. Human amniotic fluid (AF) sMD-2 was studied by Western blotting in 152 AF samples of patients who had an amniocentesis to rule-out infection (yes infection, n = 50; no infection, n = 50) or women with normal pregnancy outcome (second trimester genetic karyotyping, n = 26; third trimester lung maturity testing, n = 26). Histological localization and mRNA expression of MD2 in fetal membranes were studied by immunohistochemistry and RT-PCR. The ability of fetal membrane to release sMD-2 and inflammatory cytokines was studied in vitro. Human AF contains three sMD-2 proteoforms whose levels of expression were lower at term. Intra-amniotic infection upregulated sMD-2. MD-2 mRNA and immunohistochemistry findings concurred. In vitro, LPS and monensin increased, while cycloheximide decreased sMD-2 production. Recombinant sMD-2 modulated TNF-α and IL-6 levels in a dose- and time-dependent fashion. sMD2 proteoforms are constitutively present in human AF. The intensity of the intra-amniotic inflammatory response to bacteria or perhaps to other TLR4 ligands may be facilitated through synthesis and release of sMD2 by the amniochorion. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Does Sodium Knowledge Affect Dietary Choices and Health Behaviors? Results From a Survey of Los Angeles County Residents.

Science.gov (United States)

Dewey, George; Wickramasekaran, Ranjana N; Kuo, Tony; Robles, Brenda

2017-11-22

In 2010, the Los Angeles County Department of Public Health launched a local sodium-reduction initiative to address the rising prevalence of high blood pressure (hypertension) and related cardiovascular conditions in the population. To inform this effort, we evaluated self-reported knowledge and health behaviors related to sodium intake among Los Angeles County residents. We administered 3 cross-sectional Internet panel surveys on knowledge about dietary sodium to a sample of Los Angeles County adults, at intervals from December 2014 through August 2016. Multinomial and logistic regression models were constructed to describe associations between sodium knowledge and self-reported health behaviors. A total of 7,067 panel subjects clicked into the online survey, and 2,862 completed the survey (adjusted response rate = 40.5%). Only 102 respondents (3.6%) were able to accurately report the recommended milligrams of sodium that an average adult should consume daily (1,500 mg to 2300 mg). Knowing about daily sodium intake recommendations was associated with increased odds of using Nutrition Facts labels to make food purchase decisions (adjusted odds ratio [AOR], 3.48; 95% confidence interval [CI], 1.59-7.60) and with decreased odds of taking measures to prevent hypertension (AOR, 0.38; 95% CI, 0.19-0.74). Los Angeles County residents had a limited knowledge of recommended daily sodium intake. Efforts to increase understanding of these recommendations may encourage wider engagement in healthy behaviors. Health agencies should integrate sodium reduction messages in their diet and nutrition educational efforts.

Thomas Secker M.D.: Archbishop and man-midwife.

Science.gov (United States)

Morgan-Guy, John

2018-05-01

This paper provides a biographical outline of the career of Thomas Secker, MD, who from 1758-68 was Archbishop of Canterbury. Although much has been written on Secker, this study seeks to highlight his training in medicine, which has been largely overlooked hitherto by historians.

Neuromodulators for Aging Skin

Science.gov (United States)

... Light treatment to the skin and Restylane to tear troughs and outer eyebrow. Photo courtesy of Rebecca Fitzagerald, MD - Los Angeles, California Possible risks Soreness Mild bruising Temporary weakness of surrounding muscles Headache Drooping eyelid Why choose neuromodulators for aging ...

Risk Factors for Dog Relinquishment to a Los Angeles Municipal Animal Shelter

Science.gov (United States)

Dolan, Emily D.; Scotto, Jamie; Slater, Margaret; Weiss, Emily

2015-01-01

Simple Summary Low income has been reported to be a risk factor for dog relinquishment to shelters in the U.S. The majority of people with lower incomes, however, do not relinquish. Risk factors for relinquishment in a low socioeconomic region of Los Angeles were examined. Cost was associated with relinquishment, and most people were not aware of available assistance. Those who relinquished reported emotional attachment to the dog and higher perceived stress than a comparison group. The majority of reasons for relinquishment were likely solvable with assistance, highlighting an opportunity to provide community-specific alternatives to relinquishment. Abstract Dog relinquishment is a large component of shelter intake in the United States. Research has shown traits of the dog are associated with relinquishment as well as general characteristics of those relinquishing. Low income is often cited as a risk factor for relinquishment. The majority of people with lower incomes, however, do not relinquish. A group of people accessing a shelter in a low socioeconomic region of Los Angeles to relinquish their dogs was surveyed. This study examined risk factors for relinquishment, controlling for household income, compared to a group utilizing low cost spay/neuter services. A total of 76.9% of those relinquishing noted cost as a reason for relinquishment. Of participants in the relinquishment group, 80.7% reported not being aware of any services available to them. Most notable in the findings was that the odds of relinquishment were generally higher as the amount of perceived stress in the home in the past three months increased. The majority of people in both groups reported being emotionally attached to the dog. In this sample from a South Los Angeles community, the majority of reasons for relinquishment were likely solvable with assistance. These findings highlight an opportunity to assess community needs and provide community specific alternatives to relinquishment. PMID

Los Angeles OneSource System Youth Participant Customer Satisfaction Survey, 2010-2011

Science.gov (United States)

Heisley, Deborah D.; Moore, Richard W.; Patch, Robin N.

2012-01-01

As part of the Workforce Investment Act of 1998, Los Angeles OneSource Centers offer low-income youth ages 14-21 services aimed at improving educational achievement, enhancing job skills, and preparing for college. The primary purpose of this study was to evaluate the youths' satisfaction with services received at 14 OneSource Centers throughout…

First case of synophthalmia and albinism in the Pacific angel shark Squatina californica.

Science.gov (United States)

Escobar-Sánchez, O; Moreno-Sánchez, X G; Aguilar-Cruz, C A; Abitia-Cárdenas, L A

2014-08-01

The first record in Mexican waters of albinism and synophthalmia (partial cyclopia) in the Pacific angel shark, Squatina californica is presented. Albinism is not lethal, but synophthalmia may cause the death of the individual immediately after birth. © 2014 The Fisheries Society of the British Isles.

Humanized TLR4/MD-2 mice reveal LPS recognition differentially impacts susceptibility to Yersinia pestis and Salmonella enterica.

Directory of Open Access Journals (Sweden)

Adeline M Hajjar

Full Text Available Although lipopolysaccharide (LPS stimulation through the Toll-like receptor (TLR-4/MD-2 receptor complex activates host defense against Gram-negative bacterial pathogens, how species-specific differences in LPS recognition impact host defense remains undefined. Herein, we establish how temperature dependent shifts in the lipid A of Yersinia pestis LPS that differentially impact recognition by mouse versus human TLR4/MD-2 dictate infection susceptibility. When grown at 37°C, Y. pestis LPS is hypo-acylated and less stimulatory to human compared with murine TLR4/MD-2. By contrast, when grown at reduced temperatures, Y. pestis LPS is more acylated, and stimulates cells equally via human and mouse TLR4/MD-2. To investigate how these temperature dependent shifts in LPS impact infection susceptibility, transgenic mice expressing human rather than mouse TLR4/MD-2 were generated. We found the increased susceptibility to Y. pestis for "humanized" TLR4/MD-2 mice directly paralleled blunted inflammatory cytokine production in response to stimulation with purified LPS. By contrast, for other Gram-negative pathogens with highly acylated lipid A including Salmonella enterica or Escherichia coli, infection susceptibility and the response after stimulation with LPS were indistinguishable between mice expressing human or mouse TLR4/MD-2. Thus, Y. pestis exploits temperature-dependent shifts in LPS acylation to selectively evade recognition by human TLR4/MD-2 uncovered with "humanized" TLR4/MD-2 transgenic mice.

Humanized TLR4/MD-2 mice reveal LPS recognition differentially impacts susceptibility to Yersinia pestis and Salmonella enterica.

Science.gov (United States)

Hajjar, Adeline M; Ernst, Robert K; Fortuno, Edgardo S; Brasfield, Alicia S; Yam, Cathy S; Newlon, Lindsay A; Kollmann, Tobias R; Miller, Samuel I; Wilson, Christopher B

2012-01-01

Although lipopolysaccharide (LPS) stimulation through the Toll-like receptor (TLR)-4/MD-2 receptor complex activates host defense against Gram-negative bacterial pathogens, how species-specific differences in LPS recognition impact host defense remains undefined. Herein, we establish how temperature dependent shifts in the lipid A of Yersinia pestis LPS that differentially impact recognition by mouse versus human TLR4/MD-2 dictate infection susceptibility. When grown at 37°C, Y. pestis LPS is hypo-acylated and less stimulatory to human compared with murine TLR4/MD-2. By contrast, when grown at reduced temperatures, Y. pestis LPS is more acylated, and stimulates cells equally via human and mouse TLR4/MD-2. To investigate how these temperature dependent shifts in LPS impact infection susceptibility, transgenic mice expressing human rather than mouse TLR4/MD-2 were generated. We found the increased susceptibility to Y. pestis for "humanized" TLR4/MD-2 mice directly paralleled blunted inflammatory cytokine production in response to stimulation with purified LPS. By contrast, for other Gram-negative pathogens with highly acylated lipid A including Salmonella enterica or Escherichia coli, infection susceptibility and the response after stimulation with LPS were indistinguishable between mice expressing human or mouse TLR4/MD-2. Thus, Y. pestis exploits temperature-dependent shifts in LPS acylation to selectively evade recognition by human TLR4/MD-2 uncovered with "humanized" TLR4/MD-2 transgenic mice.

Remote sensing of trend and seasonal variability of greenhouse gas emissions from the Los Angeles basin using an FTS on Mount Wilson

Science.gov (United States)

Wong, C.; Fu, D.; Pongetti, T. J.; Newman, S.; Yung, Y. L.; Sander, S. P.

2013-12-01

Cities, such as Los Angeles, are significant sources of anthropogenic greenhouse gases (GHGs). With the growth of populations in cities worldwide, GHG emissions will increase, and monitoring the temporal trends will provide crucial data for global climate models as well as assessments of the effectiveness of control policies. Currently, continuous GHG observations in the Los Angeles basin are limited to a few in situ measurements, which are shown to be sensitive to local emissions and do not represent the Los Angeles basin well. To quantify GHG emissions from the metropolitan area, which tend to have heterogeneous characteristics, it is important to perform measurements which provide both continuous temporal and spatial coverage of the domain. Here we present observations of the major greenhouse gases, CO2 and CH4, using a spectroscopic remote sensing technique from the California Laboratory for Atmospheric Remote Sensing (CLARS) at Mount Wilson, California (1.7 km elevation). A Fourier Transform Spectrometer (FTS) deployed at the CLARS site points downward at 28 selected land surfaces in the Los Angeles basin to measure the slant column abundances of CO2, CH4, N2O, CO and O2 using reflected sunlight in the near-infrared and shortwave infrared regions. This remote sensing technique provides continuous temporal and spatial measurements in the Los Angeles basin to achieve the goal of quantifying emissions of GHGs and CO. It also serves as a test-bed for future geostationary satellite missions to measure GHGs from space such as JPL's Geostationary Carbon Process Investigation (GCPI). The path-averaged dry-air mixing ratio, XCO2 and XCH4, observed by the CLARS FTS, show significant diurnal variability that arises from emissions in the Los Angeles basin and atmospheric transport processes. High-precision data have been collected since August 2011. Here we analyze the annual and seasonal trend of the ratio XCH4:XCO2 in the Los Angeles basin observed by the CLARS FTS from

Strategic Plan for Sustainable Energy Management and Environmental Stewardship for Los Angeles Unified School District

Energy Technology Data Exchange (ETDEWEB)

Walker, A.; Beattie, D.; Thomas, K.; Davis, K.; Sim, M.; Jhaveri, A.

2007-11-01

This Strategic Plan for Sustainable Energy Management and Environmental Stewardship states goals, measures progress toward goals and how actions are monitored to achieve continuous improvement for the Los Angeles Unified School District.

The conundrum of police officer-involved homicides: Counter-data in Los Angeles County

Directory of Open Access Journals (Sweden)

Morgan Currie

2016-08-01

Full Text Available This paper draws from critical data studies and related fields to investigate police officer-involved homicide data for Los Angeles County. We frame police officer-involved homicide data as a rhetorical tool that can reify certain assumptions about the world and extend regimes of power. We highlight the possibility that this type of sensitive civic data can be investigated and employed within local communities through creative practice. Community involvement with data can create a countervailing force to powerful dominant narratives and supplement activist projects that hold local officials accountable for their actions. Our analysis examines four Los Angeles County police officer-involved homicide data sets. First, we provide accounts of the semantics, granularity, scale and transparency of this local data. Then, we describe a “counter data action,” an event that invited members of the community to identify the limits and challenges present in police officer-involved homicide data and to propose new methods for deriving meaning from these indicators and statistics.

Angels and Demons: The Science Behind the Scenes

Energy Technology Data Exchange (ETDEWEB)

Graf, Norman

2009-05-12

Does antimatter really exist? How and why do scientists produce and use it? Does CERN exist and is there an underground complex deep beneath the Swiss/French border? Is truth stranger than fiction? Find out at the coming public lecture. On Tuesday, May 12, SLAC physicist Norman Graf will discuss the real science behind Angels & Demons, Dan Brown's blockbuster novel and the basis of an upcoming Tom Hanks movie. Graf's' talk is one in a series of public lectures across the U.S., Canada and Puerto Rico to share the science of antimatter and the Large Hadron Collider, and the excitement of particle physics research.

Giordano da Pisa and the language of angels

Directory of Open Access Journals (Sweden)

Alessia Francone

2012-06-01

Full Text Available Among the issues about the angels considered by the Dominican preacher Giordano da Pisa, this essay studies the problem of their language. The question of the locutio angelica had become quite relevant in the scholastic thought from the XIIIth century and had been widely discussed by Thomas Aquinas and Giles of Rome; the study of this argument in Giordano da Pisa’s sermons shows the transition in the homiletic texts of a highly speculative theme and we can see how the preacher, who combines rather freely the positions of Thomas and Giles, filters the question for his lay public, simplifying the more difficult passages.

Angels and Demons: The Science Behind the Scenes

International Nuclear Information System (INIS)

Graf, Norman

2009-01-01

Does antimatter really exist? How and why do scientists produce and use it? Does CERN exist and is there an underground complex deep beneath the Swiss/French border? Is truth stranger than fiction? Find out at the coming public lecture. On Tuesday, May 12, SLAC physicist Norman Graf will discuss the real science behind Angels and Demons, Dan Brown's blockbuster novel and the basis of an upcoming Tom Hanks movie. Graf's' talk is one in a series of public lectures across the U.S., Canada and Puerto Rico to share the science of antimatter and the Large Hadron Collider, and the excitement of particle physics research.

76 FR 15214 - Special Local Regulations for Marine Events; Potomac River, Charles County, MD

Science.gov (United States)

2011-03-21

...-AA08 Special Local Regulations for Marine Events; Potomac River, Charles County, MD AGENCY: Coast Guard... for Marine Events; Potomac River, Charles County, MD'' in the Federal Register (76 FR 1381). We... follows: Sec. 100.35-T05-1113 Special Local Regulations for Marine Events; Potomac River, Charles County...

76 FR 1381 - Special Local Regulations for Marine Events; Potomac River, Charles County, MD

Science.gov (United States)

2011-01-10

...-AA08 Special Local Regulations for Marine Events; Potomac River, Charles County, MD AGENCY: Coast Guard... Regulations for Marine Events; Potomac River, Charles County, MD. (a) Regulated area. The following location... local regulations during the ``Potomac River Sharkfest Swim'' amateur swim, a marine event to be held on...

The undergraduate physics tutorial program at CSU Los Angeles assessment of utility and areas of interest

Science.gov (United States)

Avetyan, Smbat

The Physics Education Research (PER) group at the University of Washington have researched traditional teaching methods and found that students in introductory physics are lacking a conceptual understanding of the physics material. The solution they put forth is an interactive tutorial program designed to meet the lack of conceptual understanding. Since the tutorial programs inception at CSU Los Angeles in Fall 2006 no evaluation has been successfully undertaken therefore the effect of the tutorial program in the physics 200 series is deeply obscure to the department. The research has shed light on the tutorial program and brought into context its effectiveness on the overall physics 200 series courses at CSU Los Angeles. The researcher has addressed the following research questions, what overall effect does the tutorial program have on the Physics 200 series curriculum? What is the size and significance of gains attributable to the undergraduate calculus based Physics 200 series tutorial program at CSU Los Angeles? What can we learn from gains about individual weekly lessons from the Physics 200 series tutorial courses? What is the correlation of tutorial gains with student final course grades? Are the gains from the tutorial program different for genders? Is there a difference in gains based on the different students' colleges?

The Walking Renaissance: A Longitudinal Analysis of Walking Travel in the Greater Los Angeles Area, USA

Directory of Open Access Journals (Sweden)

Kenneth Joh

2015-07-01

Full Text Available Promoting walking travel is considered important for reducing automobile use and improving public health. Recent U.S. transportation policy has incentivized investments in alternative, more sustainable transportation modes such as walking, bicycling and transit in auto-oriented cities such as Los Angeles. Although many past studies have analyzed changes in walking travel across the U.S., there is little clarity on the drivers of change. We address this gap by conducting a longitudinal analysis of walking travel in the greater Los Angeles area from 2001 to 2009. We use travel diary and household data from regional and national surveys to analyze changes in walking trip shares and rates across our study area. Results show that walking has significantly increased across most of Los Angeles, and that increases in walking trips generally correspond with increases in population, employment, and transit service densities. Estimates from fixed-effects regression analysis generally suggest a positive association between population density and walking, and that higher increases in transit stop density are correlated with increased walking trips to and from transit stops. These findings illustrate how regional planning efforts to pursue a coordinated land use-transit planning strategy can help promote walking in auto-oriented or vehicle adopting cities.

A tale of two cities: residential context and risky behavior among adolescents in Los Angeles and Chicago.

Science.gov (United States)

Frank, Reanne; Bjornstrom, Eileen

2011-01-01

This article evaluates whether the at-risk behavior of adolescents is differentially influenced by community context across two metropolitan areas. Our focus is on Latino youth in particular. The data come from the Los Angeles Family and Neighborhood Survey (L.A.FANS) and the Project on Human Development in Chicago Neighborhoods (PHDCN). Multi-level models are employed to estimate the effects of community-level influences on adolescent risky behavior in Los Angeles and Chicago. Neighborhood-level influences on the at-risk behavior of youth are found to operate similarly across the two cities, such that native-born children of Latino immigrants are at greatest risk of problem behavior in co-ethnic highly segregated neighborhoods in both Los Angeles and Chicago. Similar patterns are observed for African-Americans, particularly in Chicago and Non-Latino Whites in both cities. We argue that the findings are best interpreted through a segregation framework. Members of each racial/ethnic group appear to exhibit negative health risk behaviors when they reside in areas that are disproportionately populated with their co-ethnic peers. Copyright © 2010 Elsevier Ltd. All rights reserved.

Summary of LHC MD 369: DOROS vs WBTN in IR Stripline BPMs

CERN Document Server

Draskovic, Drasko; Calvo Giraldo, Eva; Olexa, Jakub; Gasior, Marek; CERN. Geneva. ATS Department

2015-01-01

The aim of this MD is to quantify the impact of the stripline beam position monitor (BPM) directivity with two acquisition chain electronics systems, WBTN (Wide Band Time Normalizer) and DOROS (Diode ORbit and Oscillation System). This impact depends on the relative position and intensity of the two beams at the location of the monitor. This note explains all the procedures of the LHC MD 369, which took place on 20/07/2015 and presents the obtained results.

Edificio de archivos en Los Angeles

Directory of Open Access Journals (Sweden)

Neutra & Alexander, Arquitectos

1963-07-01

Full Text Available The 80th birthday of Richard Neutra coincides with the completion of this building, a special feature of which is that it has 13 half-floor levels, thus saving space and making it easier to reach the documents. Besides housing the Territorial Archives Office, it accommodates the Territorial Testing Dept., Regional Planning Committee and Territorial Library. 40 ms high rotary sun shields are fitted, made of aluminium. They are controlled automatically by electronic devices, motivated by the solar action, and are thus correctly orientated at any time to provide protection against sun glare. They close altogether when the wind speed is such that they might be damaged. On the main facade looking towards Temple Street, the plastic arts organisation has contributed a large mosaic by Joseph Young, showing a map of the district. This archives building in Los Angeles is a fine exponent of what technology can do for man, and it is a characteristic example of contemporary organic architecture at its best.El principio de la octava década de Neutra coincide con la terminación del edificio, cuya sección nos ofrece trece medias plantas, para economizar espacio y facilitar el alcance de los documentos. Aloja, además de la Oficina Territorial de Archivos, otras varias: Departamento Territorial de Pruebas, Comisión de Planificación Regional y Biblioteca Territorial. Unos «brise-soleils» giratorios, de aluminio, de 40 m de altura, que funcionan automáticamente —controlados por un cerebro electrónico— bajo la acción solar, proporcionan la orientación «adecuada» en cada momento y protegen del brillo lateral, cerrándose cuando el viento sopla con una velocidad que puede serles perjudicial. Como aportación de las Artes Plásticas aparece en la fachada principal, que da a la calle Temple, un gran mosaico, de Joseph Young, del mapa del territorio. Este edificio de archivos en Los Angeles constituye un claro exponente en el que la, técnica est

StandsSIM-MD: a Management Driven forest SIMulator

Energy Technology Data Exchange (ETDEWEB)

Barreiro, S.; Rua, J.; Tomé, M.

2016-07-01

Aim of the study. The existing stand level forest simulators available in Portugal were not developed with the aim of including up-to-date model versions and were limited in terms of accounting for forest management. The simulators’ platform, sIMfLOR was recently created to implement different growth models with a common philosophy. The objective was developing one easily-updatable, user-friendly, forest management and climate change sensitive simulator capable of projecting growth for the main tree species in Portugal. Area of the study: Portugal. Material and methods: The new simulator was programmed in a modular form consisting of several modules. The growth module integrates different forest growth and yield models (empirical and process-based) for the main wood production tree species in Portugal (eucalypt, umbrella and maritime pines); whereas the management module drives the growth projections along the planning horizon according to a range of forest management approaches and climate (at present only available for eucalypt). Main results: The main result is the StandsSIM-MD Management Driven simulator that overcomes the limitations of the existing stand level simulators. It is a step forward when compared to the models currently available in the sIMfLOR platform covering more tree species, stand structures and stand compositions. It is focused on end-users and it is based on similar concepts regarding the generation of required inputs and generated outputs. Research highlights: Forest Management Driven simulations approach. Multiple Prescriptions-Per-Stand functionality. StandsSIM-MD can be used to support landowners decisions on stand forest management. StandsSIM-MD simulations at regional level can be combined with optimization routines. (Author)

Effect of salinity and temperature on treatment of concentrated wastewater from RO by FO-MD

Science.gov (United States)

Zhou, Yingru; Huang, Manhong; Deng, Qian

2018-02-01

In this study the appropriate temperature of the membrane distillation (MD) hot side (the permeation flux of MD was controlled by adjusting the hot side temperature) was selected according to the water flux of FO process so that the water transfer rate on both sides of FO and MD was consistent and the FO-MD process could be stable operation. When the salt concentration of feed solution was 30, 55, 80 and 100 g/L, the desalination rates changed little, which were 99.1%, 98.4%, 98.9% and 98.7%, respectively. The removal rate of COD was 93.8%, 94.2%, 91.6% and 92.7% which also changed little like the desalination rates. The removal rate of chromaticity increased with the increase of salinity, which attained 96.6%, 97.0%, 97.2% and 97.9%, respectively. This study proved that salinity of the feed solution affected little on the removal rate of contaminants but great on the water flux, with the increase of salinity from 30 to 100 g/L, the water flux was 6.05, 4.81, 4.33 and 3.87 LMH with the appropriate temperature (67.5±0.5, 64.5±0.5, 62.5±0.5 and 60.5±0.5 °C) of MD hot side. In a word, FO-MD was first used to treat the high salinity RO water with over 30 g/L total dissolved solids (TDS), FO-MD was a promising new process for high salinity wastewater treatment, and the hybrid system can solve the problem of lower draw solution concentration, and the high-quality production water will be obtained directly by this hybrid system with low membrane fouling tendency.

Tropical Cyclone Report, 1990.

Science.gov (United States)

1990-01-01

organization as system underwent increased vertical wind shear and loss of latent and sensible heat. HI. TRACK AND MOTION After initially tracking...PASADENA CIUDAD UNIVERSITARIA. MEXICO LISD CAMP SPRINGS CENTER, MD CIVIL DEFENSE, BELAU LOS ANGELES PUBLIC LIBRARY CIVIL DEFENSE, MAJURO MAURITIUS

77 FR 6708 - Special Local Regulations for Marine Events; Potomac River, Charles County, MD

Science.gov (United States)

2012-02-09

...-AA08 Special Local Regulations for Marine Events; Potomac River, Charles County, MD AGENCY: Coast Guard... River, Charles County, MD. (a) Regulated area. The following location is a regulated area: All waters of... local regulations during the ``Potomac River Sharkfest Swim'' amateur swim, a marine event to be held on...

Teaching case studies on earthquake preparedness efforts in the transportation sector, Los Angeles metropolitan area.

Science.gov (United States)

2013-01-01

Through the development of a Harvard Kennedy School case study (intended for : use as curriculum in graduate-level and executive education programs), this project : examines earthquake preparedness and planning processes in the Los Angeles : metropol...

Opinion of stakeholders on existing curriculum for postgraduate (MD) course in Pharmacology: A survey.

Science.gov (United States)

Badyal, Dinesh K; Daniel, Sujit R

2016-10-01

To survey the opinion about various curricular components of Doctor of Medicine (MD) pharmacology curriculum in India by stakeholders, including faculty and students. An online survey was done to evaluate the various curricular components of MD pharmacology curriculum being used in India. A total of 393 respondents including faculty, MD students, and other stakeholders completed the survey. The survey was developed using SurveyMonkey platform and link to survey was E-mailed to stakeholders. The results were expressed as percentages. There was a balanced representation of respondents from various designations, teaching experience, regions, and age groups. Most of the respondents (83%) were aware of the MD pharmacology curriculum. However, they reported that it is more inclined to knowledge domain. About half of respondents (53%) said that animal experiments are being used. The most common teaching methods mentioned are seminars (98.5%), journal clubs (95%), and practical exercises by postgraduates (73%), but there is less use of newer methods (25%) in theory and less of clinical pharmacology exercise (39%) in practical classes. The log books are maintained but not assessed regularly. Internal assessment is sparingly used. The MD pharmacology curriculum needs to be made uniform at the national level and updated to include the newer methods in teaching-learning and assessment. There should be sharing of newer methods at a common platform implemented at the national level.

'Dear diary I saw an angel, she looked like heaven on earth': Sex ...

African Journals Online (AJOL)

'Dear diary I saw an angel, she looked like heaven on earth': Sex talk and sex ... gender, sexuality and HIV/AIDS education' and was conducted in Botswana, Kenya, ... problematising them, and without reproducing stereotypes of boys as subjects ... themselves and talk about sexual desire and the opposite sex in different

Review of 40-year MD theses in Medical Oncology

International Nuclear Information System (INIS)

Zeeneldin, A.; Diyaa, A.; Elgammal, M.; Buhoush, W.; Manar Moneer, M.

2014-01-01

Background and objective: It is almost 40 years since the foundation of the Medical Oncology (MO) Department. We aimed to appraise the clinical research to fulfill the Medical Doctorate (MD) degree in MO at the National Cancer Institute, Cairo University (NCI, CU). Methods: This review included 62 MD theses containing 66 studies. They were reviewed regarding aims, type of study, clinical trial phase, design and methodology, statistical tests, results, limitations, consent and IRB approval. Theses were grouped into 3 periods: 1970-1989, 1990-1999 and 2000- 2008. Results: Almost 76% of the studies were interventional and 24% were observational. Informed consent and Institutional Review Board approval were mentioned in 18 and 2 studies, respectively. While all studies mentioned the aims, none, clearly mentioned the research question. Outcomes were mainly efficacy followed by safety. Study design was inadequately considered, especially in 70’s–80’s period (p = 0.038). Median sample size and study duration were almost stable through the three periods (p = 0.441, 0.354, respectively). Most of the studies used both descriptive and analytical statistical methods. In a descending order, researched cancers were lymphoma, breast, leukemia, liver, urinary bladder, lung and colorectal. The commonest stages researched were IV and III. The number of studies focused on assessing biomarkers, biomarkers plus drugs/procedures, drugs and procedures are 20, 20, 16 and 6, respectively. Conclusion: With time, research within MD theses in MO increased quantitatively and qualitatively. Improvements were noticeable in documentation of study design.

Impact of restaurant hygiene grade cards on foodborne-disease hospitalizations in Los Angeles County.

Science.gov (United States)

Simon, Paul A; Leslie, Phillip; Run, Grace; Jin, Ginger Zhe; Reporter, Roshan; Aguirre, Arturo; Fielding, Jonathan E

2005-03-01

Although health departments routinely inspect restaurants to assess compliance with established hygienic standards, few data are available on the effectiveness of these efforts in preventing foodborne disease. The study reported here assessed the impact on foodborne-disease hospitalizations in Los Angeles County of a restaurant hygiene grading system that utilized publicly posted grade cards. The grading systm was introduced in January 1998. Hospital discharge data on foodborne-disease hospitalizations were analyzed for Los Angeles County and, as a control, for the rest of California during the period 1993-2000. Ordinary least-squares regression analysis was done to measure the effect of the grading progam on these hospitalizations. After baseline temporal and geographic trends were adjusted for, the restaurant hygiene grading program was associated with a 13.1 percent decrease (p restaurant hygiene grading with public posting of results is an effective intervention for reducing the burden of foodborne disease.

75 FR 76688 - Drawbridge Operation Regulation; Isle of Wight (Sinepuxent) Bay, Ocean City, MD

Science.gov (United States)

2010-12-09

..., mile 0.5, at Ocean City, with a vertical clearance of 13 feet above mean high tide in the closed...-AA09 Drawbridge Operation Regulation; Isle of Wight (Sinepuxent) Bay, Ocean City, MD AGENCY: Coast... Ocean City, MD. This proposed rule will require any mariner requesting an opening in the evening hours...

Immigrant incorporation in the garment industry of Los Angeles.

Science.gov (United States)

Light, I; Bernard, R B; Kim, R

1999-01-01

This study expands immigrant social network theory and examined employment patterns in the garment industry in Los Angeles, California, among Latino workers employed by Asian immigrant entrepreneurs. The study determined that a large percentage of immigrant employees found their jobs through the immigrant economy. Entrepreneurship increased the supply of local jobs and expanded the economy at destination at no expense to natives. Immigrant entrepreneurs bought firms from nonimmigrant owners or started new ones with an immigrant labor supply. Massey's index is flawed due to its exclusion of the role of entrepreneurs. Migration networks facilitate entrepreneurship, but some ethnic groups have fewer entrepreneurs, such as Mexicans and Central Americans. A 1993 Los Angeles survey identified 3642 garment factories in its county. Mean employment was 27.1 persons. The garment industry was the 4th largest industry in the area in 1996, with 98,700 employees. It represented 6% of all wage and salary employees in the City and 5.5% of the immigrant labor force in the County in 1990. 93% of garment workers in 1990 were immigrants. It is estimated that 51% of garment factory owners were Asians; most employees were Latinos. Census figures on sewing machine operators indicated 47.3% of owners were Whites and 42.45 were Asians. 53.3% of employees were other ethnic groups, 14.5% were Asians, and 32.2% were Whites. It is estimated that 47.2% of total employment was due to the immigration economy. 71.5% of the total employment in the garment industry was in the immigrant sector.

MD Test of a Ballistic Optics

CERN Document Server

Garcia-Tabares Valdivieso, Ana; Salvachua Ferrando, Belen Maria; Skowronski, Piotr Krzysztof; Solfaroli Camillocci, Matteo; Tomas Garcia, Rogelio; Wenninger, Jorg; Coello De Portugal - Martinez Vazquez, Jaime Maria; CERN. Geneva. ATS Department

2016-01-01

The ballistic optics is designed to improve the understanding of optical errors and BPM systematic effects in the critical triplet region. The particularity of that optics is that the triplet is switched off, effectively transforming the triplets on both sides of IR1 and IR5 into drift spaces. Advantage can be taken from that fact to localize better errors in the Q4-Q5-triplet region. During this MD this new optics was tested for the first time at injection with beam 2.

MD/MBA programs in the United States: evidence of a change in health care leadership.

Science.gov (United States)

Larson, David B; Chandler, Maria; Forman, Howard P

2003-03-01

Managerial sciences are playing an increasingly prominent role in the organization and delivery of health care. Despite popular media reports that a rising number of physicians are acquiring a background in this discipline through MD/MBA (medical and master of business administration) programs, no recent study has verified this. This study measured changes in the number and nature of the affiliations between management and medicine in the form of MD/MBA programs in the United States. Surveys of admission officers of 125 U.S. allopathic medical schools and of the overseers of each joint MD/MBA degree program were administered in May-October 2001. Main outcome measures included program growth, curriculum and degree requirements, application and admission requirements, and program leadership and organization. The number of MD/MBA programs grew from six to 33 between 1993 and 2001, and 17 more medical schools were considering establishing the joint-degree program. Ten, 15, and 20 programs produced 27, 42, and 61 graduates in 1999, 2000, and 2001, respectively, and over 100 students were expected to graduate per year when all 33 programs matured. Program structures and oversight indicate a spectrum of philosophies regarding the appropriate level of integration of the two degrees. MD/MBA programs apparently attempt to complement medical education with management education rather than the converse. The growth in the numbers of MD/MBA programs and participants indicates rising cooperation between medical and business schools and increasing interest in management education early in the careers of graduating physicians.

76 FR 14103 - The Jewelry Stream; Los Angeles, CA, Notice of Negative Determination on Reconsideration

Science.gov (United States)

2011-03-15

... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-73,145] The Jewelry Stream; Los Angeles, CA, Notice of Negative Determination on Reconsideration On November 10, 2010, the Department of... threatened with total or partial separation. [[Page 14104

MD210 Note: Creation of Hollow Bunches in the PSB

CERN Document Server

Oeftiger, Adrian; Findlay, Alan James; Hancock, Steven; Rumolo, Giovanni; CERN. Geneva. ATS Department

2016-01-01

MD210 aims for the creation of longitudinally hollow bunches in the CERN PS Booster. The first three sessions have been carried out using the radial loop feedback system in order to drive the beam on a dipolar parametric resonance (instead of the phase loop). It has been found that the damping by the phase loop inhibits the excitation of the resonance to a major extent. The hollow distributions generated under these circumstances fail to reach a satisfying bunching factor. Nonetheless, proving the principally successful application of this technique to the PS Booster promises good results once the phase loop system supports trim functions. The approach, actions and detailed results of the first three MD sessions are presented in this paper.

Shanghai Alleys, Theatrical Practice, and Cinematic Spectatorship: From Street Angel (1937 to Fifth Generation Film

Directory of Open Access Journals (Sweden)

Alexander Des Forges

2010-01-01

Full Text Available This article argues that a certain type of Shanghai film of the Republican period, exemplified by 1937’s Street Angel (馬路天使, Malu tianshi, makes use of a specific mode of spatial organization, modelled on the theatre, to represent the urban environment. In the case of Street Angel, and later on in 1964’s Stage Sisters (舞台姐妹, Wutai jiemei, the interaction between performers and audiences characteristic of the Shanghai theatre experience serves as a crucial ground on which to base calls to political action. For a variety of related reasons, both the city of Shanghai and this mode of spatial organization so closely associated with it vanish from the big screen in the 1980s and 1990s, and begin to make a return only at the turn of the new century.

76 FR 70051 - Establishment of Class D and Amendment of Class E Airspace; Los Angeles, CA

Science.gov (United States)

2011-11-10

... approach instructions currently require this communication. Also of concern was that the FAA pursues a full... Los Angeles Class B airspace area may provide a unified airspace utilization solution in the Los...

JST Thesaurus Headwords and Synonyms: Md [MeCab user dictionary for science technology term[Archive

Lifescience Database Archive (English)

Full Text Available MeCab user dictionary for science technology term Md 名詞 一般 * * * * メンデレビウム メンデレビウム メンデレビューム Thesaurus2015 200906022783221535 C CA03 UNKNOWN_1 Md

Constraining the kinematics of metropolitan Los Angeles faults with a slip-partitioning model.

Science.gov (United States)

Daout, S; Barbot, S; Peltzer, G; Doin, M-P; Liu, Z; Jolivet, R

2016-11-16

Due to the limited resolution at depth of geodetic and other geophysical data, the geometry and the loading rate of the ramp-décollement faults below the metropolitan Los Angeles are poorly understood. Here we complement these data by assuming conservation of motion across the Big Bend of the San Andreas Fault. Using a Bayesian approach, we constrain the geometry of the ramp-décollement system from the Mojave block to Los Angeles and propose a partitioning of the convergence with 25.5 ± 0.5 mm/yr and 3.1 ± 0.6 mm/yr of strike-slip motion along the San Andreas Fault and the Whittier Fault, with 2.7 ± 0.9 mm/yr and 2.5 ± 1.0 mm/yr of updip movement along the Sierra Madre and the Puente Hills thrusts. Incorporating conservation of motion in geodetic models of strain accumulation reduces the number of free parameters and constitutes a useful methodology to estimate the tectonic loading and seismic potential of buried fault networks.

Review of 40-year MD theses in medical oncology.

Science.gov (United States)

Zeeneldin, Ahmed; Diyaa, Amira; Moneer, Manar; Elgammal, Mosaad; Buhoush, Wafa

2014-09-01

It is almost 40 years since the foundation of the Medical Oncology (MO) Department. We aimed to appraise the clinical research to fulfill the Medical Doctorate (MD) degree in MO at the National Cancer Institute, Cairo University (NCI, CU). This review included 62 MD theses containing 66 studies. They were reviewed regarding aims, type of study, clinical trial phase, design and methodology, statistical tests, results, limitations, consent and IRB approval. Theses were grouped into 3 periods: 1970-1989, 1990-1999 and 2000-2008. Almost 76% of the studies were interventional and 24% were observational. Informed consent and Institutional Review Board approval were mentioned in 18 and 2 studies, respectively. While all studies mentioned the aims, none, clearly mentioned the research question. Outcomes were mainly efficacy followed by safety. Study design was inadequately considered, especially in 70's-80's period (p=0.038). Median sample size and study duration were almost stable through the three periods (p=0.441, 0.354, respectively). Most of the studies used both descriptive and analytical statistical methods. In a descending order, researched cancers were lymphoma, breast, leukemia, liver, urinary bladder, lung and colorectal. The commonest stages researched were IV and III. The number of studies focused on assessing biomarkers, biomarkers plus drugs/procedures, drugs and procedures are 20, 20, 16 and 6, respectively. With time, research within MD theses in MO increased quantitatively and qualitatively. Improvements were noticeable in documentation of study design. Copyright © 2014. Production and hosting by Elsevier B.V.

Spatial analysis of fuel treatment options for chaparral on the Angeles national forest

Science.gov (United States)

G. Jones; J. Chew; R. Silverstein; C. Stalling; J. Sullivan; J. Troutwine; D. Weise; D. Garwood

2008-01-01

Spatial fuel treatment schedules were developed for the chaparral vegetation type on the Angeles National Forest using the Multi-resource Analysis and Geographic Information System (MAGIS). Schedules varied by the priority given to various wildland urban interface areas and the general forest, as well as by the number of acres treated per decade. The effectiveness of...

A life cycle carbon dioxide inventory of the Million Trees Los Angeles Program

Science.gov (United States)

E. Gregory McPherson; Alissa Kendall

2014-01-01

PurposeThis study seeks to answer the question, “Will the Million Trees LA (Million Trees Los Angeles, MTLA) program be a carbon dioxide (CO2) sink or source?” Because there has never been a full accounting of CO2 emissions, it is unclear if urban tree planting initiatives (TPIs) are likely to be...

Self-Discovery through Character Connections: Opening up to Gayness in "Angels in America"

Science.gov (United States)

Blazar, David

2009-01-01

In this article, the author describes how he uses performance pedagogy to open students' minds to sexuality and gender issues. The author uses Tony Kushner's "Angels in America: A Gay Fantasia on National Themes"--an epic play about the AIDS epidemic and its impact on the gay community in the 1980s. Through the possibilities of drama available in…

Revisiting "Rodriguez v. Los Angeles Unified School District": A Case of Intra-District Inequities

Science.gov (United States)

Espinosa, Ruben W.

2010-01-01

The educational community and the courts continue to struggle with the challenges of intra-district resource inequality revealed by the California Supreme Court landmark case "Rodriguez v. Los Angeles Unified School District" (1992). Intra-district school resource inequality is one of the remaining bastions of major inequalities in the…

75 FR 8193 - Jeri Hassman, M.D.; Denial of Application

Science.gov (United States)

2010-02-23

... is buying drugs on the street. Id. at 1006. With respect to requests for early refills, Dr. Hare... Part II Department of Justice Drug Enforcement Administration Jeri Hassman, M.D.; Denial of...; [[Page 8194

The touch of the efficiency: the case of the tower of the angel; El toque de la eficiencia: el caso de la torre del angel

Energy Technology Data Exchange (ETDEWEB)

Trillo, Jose Luis [Ingenieria en Aire y Control (Mexico); Frias, Jose Luis [DHIMEX (Mexico)

2002-09-01

With the purpose of reducing the heat in the interior of the Tower of the Angel, building of offices located in avenida Paseo de la Reforma of Mexico City, a renovation was carried out that included the installation of an insulating crystal cover in all the building. Also, it was opted for an environmental system of air-cooling to fulfill the functions of the HVAC (Heating, Ventilation and Air Conditioning), systems. It is possible to indicate that, in addition to the energy saving, the applied technology allowed to transform an old and uncomfortable construction into a construction of worldwide class, able to compete with new works of the city and harmonize with present environmental and aesthetic requirements. [Spanish] Con objeto de reducir el calor al interior de la Torre del Angel, edificio de oficinas ubicado en la avenida Paseo de la Reforma de la Ciudad de Mexico, se llevo a cabo una renovacion que incluyo la instalacion de una cubierta de cristal aislante en todo el inmueble. Asimismo, se opto por un sistema ambiental de enfriamiento de aire para cumplir con las funciones de los sistemas HVAC (Heating, Ventilation and Air Conditioning, por sus siglas en ingles). Cabe senalar que, ademas del ahorro energetico, la tecnologia aplicada permitio transformar una construccion vieja e incomoda en una edificacion de clase mundial, capaz de competir con las nuevas obras de la ciudad y armonizar con los requerimientos ambientales y esteticos actuales.

MD-portal: Highly Effective Website for Nuclear Materials Information Management

International Nuclear Information System (INIS)

Kil, Soyeon; Lee, Gyeonggeun; Kwon, Junhyun

2014-01-01

A web-based system is widespread in not only everyday activities but also business fields. In past years, the systematic information of various properties of materials usually has been provided as tabulated documents; however it recently has been provided as web-based DB. There are many websites providing material properties information, representative examples include MatWeb from the United States, Granta MI from England and MatNavi from Japan. In 2003, the nuclear materials division in KAERI established a website about nuclear materials property DB, called MatDB. To inherit it, a website called MD-portal has been recently set up to release degradation information and various properties of nuclear materials. In this presentation, the structure and characteristics of MD-portal will be mentioned, and comments on its application will be given

The Structural Basis for Lipid and Endotoxin Binding in RP105-MD-1, and Consequences for Regulation of Host Lipopolysaccharide Sensitivity.

Science.gov (United States)

Ortiz-Suarez, Maite L; Bond, Peter J

2016-01-05

MD-1 is a member of the MD-2-related lipid-recognition (ML) family, and associates with RP105, a cell-surface protein that resembles Toll-like receptor 4 (TLR4). The RP105⋅MD-1 complex has been proposed to play a role in fine-tuning the innate immune response to endotoxin such as bacterial lipopolysaccharide (LPS) via TLR4⋅MD-2, but controversy surrounds its mechanism. We have used atomically detailed simulations to reveal the structural basis for ligand binding and consequent functional dynamics of MD-1 and the RP105 complex. We rationalize reports of endogenous phospholipid binding, by showing that they prevent collapse of the malleable MD-1 fold, before refining crystallographic models and uncovering likely binding modes for LPS analogs. Subsequent binding affinity calculations reveal that endotoxin specificity arises from the entropic cost of expanding the MD-1 cavity to accommodate bulky lipid tails, and support the role of MD-1 as a "sink" that sequesters endotoxin from TLR4 and stabilizes RP105/TLR4 interactions. Copyright © 2016 Elsevier Ltd. All rights reserved.

MD and BCA simulations of He and H bombardment of fuzz in bcc elements

Science.gov (United States)

Klaver, T. P. C.; Zhang, S.; Nordlund, K.

2017-08-01

We present results of MD simulations of low energy He ion bombardment of low density fuzz in bcc elements. He ions can penetrate several micrometers into sparse fuzz, which allows for a sufficient He flux through it to grow the fuzz further. He kinetic energy falls off exponentially with penetration depth. A BCA code was used to carry out the same ion bombardment on the same fuzz structures as in MD simulations, but with simpler, 10 million times faster calculations. Despite the poor theoretical basis of the BCA at low ion energies, and the use of somewhat different potentials in MD and BCA calculations, the ion penetration depths predicted by BCA are only ∼12% less than those predicted by MD. The MD-BCA differences are highly systematic and trends in the results of the two methods are very similar. We have carried out more than 200 BCA calculation runs of ion bombardment of fuzz, in which parameters in the ion bombardment process were varied. For most parameters, the results show that the ion bombardment process is quite generic. The ion species (He or H), ion mass, fuzz element (W, Ta, Mo, Fe) and fuzz element lattice parameter turned out to have a modest influence on ion penetration depths at most. An off-normal angle of incidence strongly reduces the ion penetration depth. Increasing the ion energy increases the ion penetration, but the rate by which ion energy drops off at high ion energies follows the same exponential pattern as at lower energies.

Postgraduate research training: the PhD and MD thesis.

Science.gov (United States)

Higginson, I; Corner, J

1996-04-01

Higher research degrees, such as the PhD, MPhil and MD, have existed within universities for 80 years or more, although the differences between the MD and PhD remain confused. A higher research degree training provides individuals with greater research knowledge and skills, and benefits the specialty. Concern exists about the levels of supervision sometimes provided, failure to complete degrees, and the variable levels of research knowledge and skills attained. We propose that higher research degrees in palliative care have four functions: extending personal scholarship, generating knowledge, training for the individual and contributing to the growth of the specialty. Such an approach may include: a formalised first year with taught components such as in research MSc programmes, formal supervision and progress assessment. In palliative care, clinical and academic approaches need greater integration. Multiprofessional learning is essential. To allow individuals to undertake higher research degree programmes, fellowships or specific funding are needed.

MD1003 (high-dose biotin) for the treatment of progressive multiple sclerosis: A randomised, double-blind, placebo-controlled study.

Science.gov (United States)

Tourbah, Ayman; Lebrun-Frenay, Christine; Edan, Gilles; Clanet, Michel; Papeix, Caroline; Vukusic, Sandra; De Sèze, Jerome; Debouverie, Marc; Gout, Olivier; Clavelou, Pierre; Defer, Gilles; Laplaud, David-Axel; Moreau, Thibault; Labauge, Pierre; Brochet, Bruno; Sedel, Frédéric; Pelletier, Jean

2016-11-01

Treatment with MD1003 (high-dose biotin) showed promising results in progressive multiple sclerosis (MS) in a pilot open-label study. To confirm the efficacy and safety of MD1003 in progressive MS in a double-blind, placebo-controlled study. Patients (n = 154) with a baseline Expanded Disability Status Scale (EDSS) score of 4.5-7 and evidence of disease worsening within the previous 2 years were randomised to 12-month MD1003 (100 mg biotin) or placebo thrice daily, followed by 12-month MD1003 for all patients. The primary endpoint was the proportion of patients with disability reversal at month 9, confirmed at month 12, defined as an EDSS decrease of ⩾1 point (⩾0.5 for EDSS 6-7) or a ⩾20% decrease in timed 25-foot walk time compared with the best baseline among screening or randomisation visits. A total of 13 (12.6%) MD1003-treated patients achieved the primary endpoint versus none of the placebo-treated patients (p = 0.005). MD1003 treatment also reduced EDSS progression and improved clinical impression of change compared with placebo. Efficacy was maintained over follow-up, and the safety profile of MD1003 was similar to that of placebo. MD1003 achieves sustained reversal of MS-related disability in a subset of patients with progressive MS and is well tolerated. © The Author(s), 2016.

The mycorrhiza-dependent defensin MtDefMd1 of Medicago truncatula acts during the late restructuring stages of arbuscule-containing cells.

Directory of Open Access Journals (Sweden)

Marian Uhe

Full Text Available Different symbiotic and pathogenic plant-microbe interactions involve the production of cysteine-rich antimicrobial defensins. In Medicago truncatula, the expression of four MtDefMd genes, encoding arbuscular mycorrhiza-dependent defensins containing an N-terminal signal peptide and exhibiting some differences to non-symbiotic defensins, raised over the time of fungal colonization. Whereas the MtDefMd1 and MtDefMd2 promoters were inactive in cells containing young arbuscules, cells with fully developed arbuscules displayed different levels of promoter activities, indicating an up-regulation towards later stages of arbuscule formation. MtDefMd1 and MtDefMd2 expression was absent or strongly down-regulated in mycorrhized ram1-1 and pt4-2 mutants, known for defects in arbuscule branching or premature arbuscule degeneration, respectively. A ~97% knock-down of MtDefMd1/MtDefMd2 expression did not significantly affect arbuscule size. Although overexpression of MtDefMd1 in arbuscule-containing cells led to an up-regulation of MtRam1, encoding a key transcriptional regulator of arbuscule formation, no morphological changes were evident. Co-localization of an MtDefMd1-mGFP6 fusion with additional, subcellular markers revealed that this defensin is associated with arbuscules in later stages of their life-cycle. MtDefMd1-mGFP6 was detected in cells with older arbuscules about to collapse, and ultimately in vacuolar compartments. Comparisons with mycorrhized roots expressing a tonoplast marker indicated that MtDefMd1 acts during late restructuring processes of arbuscule-containing cells, upon their transition into a post-symbiotic state.

MD 349: Impedance Localization with AC-dipole

CERN Document Server

Biancacci, Nicolo; Metral, Elias; Salvant, Benoit; Papotti, Giulia; Persson, Tobias Hakan Bjorn; Tomas Garcia, Rogelio; CERN. Geneva. ATS Department

2016-01-01

The purpose of this MD is to measure the distribution of the transverse impedance of the LHC by observing the phase advance variation with intensity between the machine BPMs. Four injected bunches with different intensities are excited with an AC dipole and the turn by turn data is acquired from the BPM system. Through post-processing analysis the phase variation along the machine is depicted and, from this information, first conclusions of the impedance distribution can be drawn.

MD and FFM Electron Broadening for Warm and Dense Hydrogen Plasmas

International Nuclear Information System (INIS)

Ferri, S.; Calisti, A.; Mosse, C.; Talin, B.; Gonzalez, M. A.; Gigosos, M. A.

2006-01-01

Direct integration of the semi-classical evolution equation based on Molecular Dynamics simulations (MD) and the Frequency Fluctuation Model (FFM) have long been used to synthesize spectra accounting for ion dynamics. Cross comparisons of these approaches generally show results in good agreement. Recently, interest in low temperature (Te ∼ 1eV) and high density (Ne ∼ 1018 cm-3) hydrogen plasma spectroscopy has motivated extended applications of FFM. Arising discrepancies were found to originate in electron collision operators suggesting an improper use of impact approximations for warm and dense plasma conditions. In order to clarify this point, new useful cross comparisons between MD and FFM have been carried out for electron broadening

The Fossil Fueled Metropolis: Los Angeles and the Emergence of Oil-Based Energy in North America, 1865--1930

Science.gov (United States)

Cooke, Jason Arthur

Beginning with coal in the nineteenth century, the mass production and intensive consumption of fossil fuel energy fundamentally changed patterns of urban and industrial development in North America. Focusing on the metropolitan development of Los Angeles, this dissertation examines how the emergence of oil-based capitalism in the first three decades of the twentieth century was sustained and made increasingly resilient through the production of urban and industrial space. In a region where coal was scarce, the development of oil-based energy was predicated on long-term investments into conversion technologies, storage systems and distribution networks that facilitated the efficient and economical flow of liquefied fossil fuel. In this dissertation, I argue that the historical and geographical significance of the Southern California petroleum industry is derived from how its distinctive market expansion in the first three decades of the twentieth century helped establish the dominance of oil-based energy as the primary fuel for transportation in capitalist society. In North America, the origins of oil-based capitalism can be traced to the turn of the twentieth century when California was the largest oil-producing economy in the United States and Los Angeles was the fastest growing metropolitan region. This dissertation traces how Los Angeles became the first city in North America where oil became a formative element of urban and industrial development: not only as fuel for transportation, but also in the infrastructures, landscapes and networks that sustain a critical dependence on oil-based energy. With a distinctive metropolitan geography, decentralized and automobile-dependent, Los Angeles became the first oil-based city in North America and thus provides an ideal case study for examining the regional dynamics of energy transition, establishment and dependence. Interwoven with the production of urban and industrial space, oil remains the primary fuel that

77 FR 56549 - Safety Zone; Blue Angels at Kaneohe Bay Air Show, Oahu, HI

Science.gov (United States)

2012-09-13

... DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 165 [Docket Number USCG-2012-0739] RIN 1625-AA00 Safety Zone; Blue Angels at Kaneohe Bay Air Show, Oahu, HI AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a temporary safety zone while the U.S. Navy...

75 FR 50952 - Safety Zone; Blue Angels at Kaneohe Bay Air Show, Oahu, HI

Science.gov (United States)

2010-08-18

... DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 165 [Docket No. USCG-2010-0705] RIN 1625-AA00 Safety Zone; Blue Angels at Kaneohe Bay Air Show, Oahu, HI AGENCY: Coast Guard, DHS. ACTION: Notice of proposed rulemaking. SUMMARY: The Coast Guard proposes two temporary safety zones while the U.S...

Going beyond clustering in MD trajectory analysis: an application to villin headpiece folding.

Directory of Open Access Journals (Sweden)

Aruna Rajan

2010-04-01

Full Text Available Recent advances in computing technology have enabled microsecond long all-atom molecular dynamics (MD simulations of biological systems. Methods that can distill the salient features of such large trajectories are now urgently needed. Conventional clustering methods used to analyze MD trajectories suffer from various setbacks, namely (i they are not data driven, (ii they are unstable to noise and changes in cut-off parameters such as cluster radius and cluster number, and (iii they do not reduce the dimensionality of the trajectories, and hence are unsuitable for finding collective coordinates. We advocate the application of principal component analysis (PCA and a non-metric multidimensional scaling (nMDS method to reduce MD trajectories and overcome the drawbacks of clustering. To illustrate the superiority of nMDS over other methods in reducing data and reproducing salient features, we analyze three complete villin headpiece folding trajectories. Our analysis suggests that the folding process of the villin headpiece is structurally heterogeneous.

[Professor Frantisek Por MD and Professor Robert Klopstock MD, students at Budapest and Prague Faculties of Medicine].

Science.gov (United States)

Mydlík, M; Derzsiová, K

2010-11-01

Professor Frantisek Por MD and Professor Robert Klopstock MD were contemporaries, both born in 1899, one in Zvolen, the other in Dombovar, at the time of Austro-Hungarian Monarchy. Prof. Por attended the Faculty of Medicine in Budapest from 1918 to 1920, and Prof. Klopstock studied at the same place between 1917 and 1919. From 1920 until graduation on 6th February 1926, Prof. Por continued his studies at the German Faculty of Medicine, Charles University in Prague. Prof. Klopstock had to interrupt his studies in Budapest due to pulmonary tuberculosis; he received treatment at Tatranske Matliare where he befriended Franz Kafka. Later, upon Kafka's encouragement, he changed institutions and continued his studies at the German Faculty of Medicine, Charles University in Prague, where he graduated the first great go. It is very likely that, during their studies in Budapest and Prague, both professors met repeatedly, even though their life paths later separated. Following his graduation, Prof. Por practiced as an internist in Prague, later in Slovakia, and from 1945 in Kosice. In 1961, he was awarded the title of university professor of internal medicine at the Faculty of Medicine, Pavol Jozef Safarik University in Kosice, where he practiced until his death in 1980. Prof. Klopstock continued his studies in Kiel and Berlin. After his graduation in 1933, he practiced in Berlin as a surgeon and in 1938 left for USA. In 1962, he was awarded the title of university professor of pulmonary surgery in NewYork, where he died in 1972.

Applicability of effective fragment potential version 2 - Molecular dynamics (EFP2-MD) simulations for predicting excess properties of mixed solvents

Science.gov (United States)

Kuroki, Nahoko; Mori, Hirotoshi

2018-02-01

Effective fragment potential version 2 - molecular dynamics (EFP2-MD) simulations, where the EFP2 is a polarizable force field based on ab initio electronic structure calculations were applied to water-methanol binary mixture. Comparing EFP2s defined with (aug-)cc-pVXZ (X = D,T) basis sets, it was found that large sets are necessary to generate sufficiently accurate EFP2 for predicting mixture properties. It was shown that EFP2-MD could predict the excess molar volume. Since the computational cost of EFP2-MD are far less than ab initio MD, the results presented herein demonstrate that EFP2-MD is promising for predicting physicochemical properties of novel mixed solvents.

The knock-down of the expression of MdMLO19 reduces susceptibility to powdery mildew (Podosphaera leucotricha) in apple (Malus domestica).

Science.gov (United States)

Pessina, Stefano; Angeli, Dario; Martens, Stefan; Visser, Richard G F; Bai, Yuling; Salamini, Francesco; Velasco, Riccardo; Schouten, Henk J; Malnoy, Mickael

2016-10-01

Varieties resistant to powdery mildew (PM; caused by Podosphaera leucotricha) are a major component of sustainable apple production. Resistance can be achieved by knocking-out susceptibility S-genes to be singled out among members of the MLO (Mildew Locus O) gene family. Candidates are MLO S-genes of phylogenetic clade V up-regulated upon PM inoculation, such as MdMLO11 and 19 (clade V) and MdMLO18 (clade VII). We report the knock-down through RNA interference of MdMLO11 and 19, as well as the complementation of resistance with MdMLO18 in the Arabidopsis thaliana triple mlo mutant Atmlo2/6/12. The knock-down of MdMLO19 reduced PM disease severity by 75%, whereas the knock-down of MdMLO11, alone or in combination with MdMLO19, did not result in any reduction or additional reduction of susceptibility compared with MdMLO19 alone. The test in A. thaliana excluded a role for MdMLO18 in PM susceptibility. Cell wall appositions (papillae) were present in both PM-resistant and PM-susceptible plants, but were larger in resistant lines. No obvious negative phenotype was observed in plants with mlo genes knocked down. Apparently, MdMLO19 plays the pivotal role in apple PM susceptibility and its knock-down induces a very significant level of resistance. © 2016 The Authors. Plant Biotechnology Journal published by Society for Experimental Biology and The Association of Applied Biologists and John Wiley & Sons Ltd.

Origin of methane and sources of high concentrations in Los Angeles groundwater

Science.gov (United States)

Kulongoski, Justin; McMahon, Peter B.; Land, Michael; Wright, Michael; Johnson, Theodore; Landon, Matthew K.

2018-01-01

In 2014, samples from 37 monitoring wells at 17 locations, within or near oil fields, and one site >5 km from oil fields, in the Los Angeles Basin, California, were analyzed for dissolved hydrocarbon gas isotopes and abundances. The wells sample a variety of depths of an aquifer system composed of unconsolidated and semiconsolidated sediments under various conditions of confinement. Concentrations of methane in groundwater samples ranged from 0.002 to 150 mg/L—some of the highest concentrations reported in a densely populated urban area. The δ13C and δ2H of the methane ranged from −80.8 to −45.5 per mil (‰) and −249.8 to −134.9‰, respectively, and, along with oxidation‐reduction processes, helped to identify the origin of methane as microbial methanogenesis and CO2 reduction as its main formation pathway. The distribution of methane concentrations and isotopes is consistent with the high concentrations of methane in Los Angeles Basin groundwater originating from relatively shallow microbial production in anoxic or suboxic conditions. Source of the methane is the aquifer sediments rather than the upward migration or leakage of thermogenic methane associated with oil fields in the basin.

Risk Factors for Dog Relinquishment to a Los Angeles Municipal Animal Shelter

Directory of Open Access Journals (Sweden)

Emily D. Dolan

2015-12-01

Full Text Available Dog relinquishment is a large component of shelter intake in the United States. Research has shown traits of the dog are associated with relinquishment as well as general characteristics of those relinquishing. Low income is often cited as a risk factor for relinquishment. The majority of people with lower incomes, however, do not relinquish. A group of people accessing a shelter in a low socioeconomic region of Los Angeles to relinquish their dogs was surveyed. This study examined risk factors for relinquishment, controlling for household income, compared to a group utilizing low cost spay/neuter services. A total of 76.9% of those relinquishing noted cost as a reason for relinquishment. Of participants in the relinquishment group, 80.7% reported not being aware of any services available to them. Most notable in the findings was that the odds of relinquishment were generally higher as the amount of perceived stress in the home in the past three months increased. The majority of people in both groups reported being emotionally attached to the dog. In this sample from a South Los Angeles community, the majority of reasons for relinquishment were likely solvable with assistance. These findings highlight an opportunity to assess community needs and provide community specific alternatives to relinquishment.

75 FR 71455 - The Jewelry Stream, Los Angeles, CA; Notice of Affirmation Determination Regarding Application...

Science.gov (United States)

2010-11-23

... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-73,145] The Jewelry Stream, Los... Manufacturing, Inc. and The Jewelry Stream, Los Angeles, California. The termination notice was signed on August... identified in the Trade Adjustment Assistance (TAA) petition--M&L Manufacturing, Inc. and The Jewelry Stream...

The draft genome of MD-2 pineapple using hybrid error correction of long reads

Science.gov (United States)

Redwan, Raimi M.; Saidin, Akzam; Kumar, S. Vijay

2016-01-01

The introduction of the elite pineapple variety, MD-2, has caused a significant market shift in the pineapple industry. Better productivity, overall increased in fruit quality and taste, resilience to chilled storage and resistance to internal browning are among the key advantages of the MD-2 as compared with its previous predecessor, the Smooth Cayenne. Here, we present the genome sequence of the MD-2 pineapple (Ananas comosus (L.) Merr.) by using the hybrid sequencing technology from two highly reputable platforms, i.e. the PacBio long sequencing reads and the accurate Illumina short reads. Our draft genome achieved 99.6% genome coverage with 27,017 predicted protein-coding genes while 45.21% of the genome was identified as repetitive elements. Furthermore, differential expression of ripening RNASeq library of pineapple fruits revealed ethylene-related transcripts, believed to be involved in regulating the process of non-climacteric pineapple fruit ripening. The MD-2 pineapple draft genome serves as an example of how a complex heterozygous genome is amenable to whole genome sequencing by using a hybrid technology that is both economical and accurate. The genome will make genomic applications more feasible as a medium to understand complex biological processes specific to pineapple. PMID:27374615

Community-Based Health and Exposure Study around Urban Oil Developments in South Los Angeles

Directory of Open Access Journals (Sweden)

Bhavna Shamasunder

2018-01-01

Full Text Available Oilfield-adjacent communities often report symptoms such as headaches and/or asthma. Yet, little data exists on health experiences and exposures in urban environments with oil and gas development. In partnership with Promotoras de Salud (community health workers, we gathered household surveys nearby two oil production sites in Los Angeles. We tested the capacity of low-cost sensors for localized exposure estimates. Bilingual surveys of 205 randomly sampled residences were collected within two 1500 ft. buffer areas (West Adams and University Park surrounding oil development sites. We used a one-sample proportion test, comparing overall rates from the California Health Interview Survey (CHIS of Service Planning Area 6 (SPA6 and Los Angeles County for variables of interest such as asthma. Field calibrated low-cost sensors recorded methane emissions. Physician diagnosed asthma rates were reported to be higher within both buffers than in SPA6 or LA County. Asthma prevalence in West Adams but not University Park was significantly higher than in Los Angeles County. Respondents with diagnosed asthma reported rates of emergency room visits in the previous 12 months similar to SPA6. 45% of respondents were unaware of oil development; 63% of residents would not know how to contact local regulatory authorities. Residents often seek information about their health and site-related activities. Low-cost sensors may be useful in highlighting differences between sites or recording larger emission events and can provide localized data alongside resident-reported symptoms. Regulatory officials should help clarify information to the community on methods for reporting health symptoms. Our community-based participatory research (CBPR partnership supports efforts to answer community questions as residents seek a safety buffer between sensitive land uses and active oil development.

Risks for abuse against pregnant Hispanic women: Morelos, Mexico and Los Angeles County, California.

Science.gov (United States)

Castro, Roberto; Peek-Asa, Corinne; García, Lorena; Ruiz, Agustín; Kraus, Jess F

2003-11-01

Although violence against women is gaining international attention as a prevention priority, little is known about how risks differ across countries. A comparative study of violence against pregnant Mexican women in Morelos, Mexico, and Latina women in Los Angeles County, California, United States. In 1998 and 1999, women in prenatal clinics were interviewed about psychological abuse and sexual and physical violence by their partner, during and the 1 year prior to the index pregnancy. The overall response rate for Morelos was 99%, with a sample size of 914; Los Angeles County had a response rate of 96.9%, with a sample size of 219. Women in Morelos reported a higher prevalence of violence compared to women in the California (14.8% v 11.9%, respectively). A partner aged child were more than 25 times more likely to be abused during pregnancy than women not reporting this type of abuse. The identification of factors associated with violence against women, especially as they differ by culture and ethnicity, will help clinicians to better identify victims and to design and implement culturally appropriate prevention programs.

MD1831: Single Bunch Instabilities with Q" and Non-Linear Corrections

CERN Document Server

Carver, Lee Robert; De Maria, Riccardo; Li, Kevin Shing Bruce; Amorim, David; Biancacci, Nicolo; Buffat, Xavier; Maclean, Ewen Hamish; Metral, Elias; Lasocha, Kacper; Lefevre, Thibaut; Levens, Tom; Salvant, Benoit; CERN. Geneva. ATS Department

2017-01-01

During MD1751, it was observed that both a full single beam and 964 non-colliding bunches in Beam 1 (B1) and Beam 2 (B2) were both stable at the End of Squeeze (EOS) for 0A in the Landau Octupoles. At ß* = 40cm there is also a significant Q" arising from the lattice, as well as uncorrected non-linearities in the Insertion Regions (IRs). Each of these effects could be capable of fully stabilising the beam. This MD made first use of a Q" knob through variation of the Main Sextupoles (MS) by stabilising a single bunch at Flat Top, before showing at EOS that the non-linearities were the main contributors to the beam stability.

MD-CTS: An integrated terminology reference of clinical and translational medicine

Directory of Open Access Journals (Sweden)

Will Ray

2016-01-01

Full Text Available New vocabularies are rapidly evolving in the literature relative to the practice of clinical medicine and translational research. To provide integrated access to new terms, we developed a mobile and desktop online reference—Marshfield Dictionary of Clinical and Translational Science (MD-CTS. It is the first public resource that comprehensively integrates Wiktionary (word definition, BioPortal (ontology, Wiki (image reference, and Medline abstract (word usage information. MD-CTS is accessible at http://spellchecker.mfldclin.edu/. The website provides a broadened capacity for the wider clinical and translational science community to keep pace with newly emerging scientific vocabulary. An initial evaluation using 63 randomly selected biomedical words suggests that online references generally provided better coverage (73%-95% than paper-based dictionaries (57–71%.

Integrating sodium reduction strategies in the procurement process and contracting of food venues in the County of Los Angeles government, 2010-2012.

Science.gov (United States)

Cummings, Patricia L; Kuo, Tony; Gase, Lauren N; Mugavero, Kristy

2014-01-01

Since sodium is ubiquitous in the food supply, recent approaches to sodium reduction have focused on increasing the availability of lower-sodium products through system-level and environmental changes. This article reviews integrated efforts by the Los Angeles County Sodium Reduction Initiative to implement these strategies at food venues in the County of Los Angeles government. The review used mixed methods, including a scan of the literature, key informant interviews, and lessons learned during 2010-2012 to assess program progress. Leveraging technical expertise and shared resources, the initiative strategically incorporated sodium reduction strategies into the overall work plan of a multipartnership food procurement program in Los Angeles County. To date, 3 County departments have incorporated new or updated nutrition requirements that included sodium limits and other strategies. The strategic coupling of sodium reduction to food procurement and general health promotion allowed for simultaneous advancement and acceleration of the County's sodium reduction agenda.

How Our History Influences How We Raise Our Children

Science.gov (United States)

Siegel, Daniel J.

2012-01-01

Daniel J. Siegel, MD, clinical professor of psychiatry at the University of California, Los Angeles School of Medicine, discusses how early childhood experiences in one's own family have an influence on adult parenting practices. Attachment research has studied the way parents interact with their children, across all different cultures and…

The Demon-Angel method in systematic safety assessment

International Nuclear Information System (INIS)

Vassakis, A.G.

1999-01-01

Since 'design for safety' of large engineering systems with a high level of innovation requires an exhaustive safety analysis and since a subsequent corrective action may become a very large bottleneck in improving such a system, fundamental knowledge in designing safe systems is essential. The lack of any 'rule of thumb' makes such knowledge a matter of personal experience rather than the subject of an academic course. This paper proposes a new method for the theoretical safety study of different system configurations independently of any particular application. This method aims to help the construction of a 'rule of thumb' for what is a safe system and what is not. The Demon and Angel ideas are explained and the schematic presentation of these elements is introduced. Four representative case studies demonstrate the use of this method

MD1878: Operation with primary collimators at tighter settings

CERN Document Server

AUTHOR|(CDS)2078850; Amorim, David; Biancacci, Nicolo; Bruce, Roderik; Buffat, Xavier; Carver, Lee Robert; Fiascaris, Maria; Mereghetti, Alessio; Redaelli, Stefano; Rossi, Roberto; Salvachua Ferrando, Belen Maria; Soderen, Martin; Trad, Georges; CERN. Geneva. ATS Department

2017-01-01

Primary (TCP) collimators of the betatron cleaning insertion determine the betatron cut of the LHC beam. During the 2016 they were set at 5.5 nominal beam sigmas at 6.5 TeV (i.e. by using a normalized emittance ε* = 3:5 μm is used). Reducing their settings is a possible way to push the ß* at the LHC, which depends on the collimation hierarchy. This study aims at understanding possible limitations of operating the LHC with tighter settings of the primary collimators. This is a crucial input to the choice of operational configuration in terms of ß* at the LHC as well as at the HL-LHC. This study follows a successful MD done in block 3 to understand limitations from TCP impedance [1]. The outcome of this MD can also have an impact for the design of the FCC collimation system, which is currently based on the present TCP gaps. Studies of beam stability as a function of octupole current, transverse feedback gain (ADT) and transverse separation at the IPs were also carried out.

A workshop on leadership for senior MD-PhD students.

Science.gov (United States)

Meador, Catherine B; Parang, Bobak; Musser, Melissa A; Haliyur, Rachana; Owens, David A; Dermody, Terence S

2016-01-01

Leadership skills are essential for a successful career as a physician-scientist, yet many MD-PhD training programs do not offer formal training in leadership. The Vanderbilt Medical Scientist Training Program (MSTP) previously established a 2-day leadership workshop that has been held biennially since 2006 for students in the first and second years of the graduate school portion of combined MD and PhD training (G1/G2 students). Workshop attendees have consistently rated this workshop as a highly effective experience. However, opportunities for structured training in leadership competencies during the subsequent 3-5 years of MD-PhD training are limited. Given the success of the G1/G2 leadership workshop and the need for continuity in this model of leadership training, we developed a half-day workshop for MSTP students in the clinical years of medical school (M3/M4 students) to foster continued training in leadership. Our workshop curriculum, based in part on original cases drafted by Vanderbilt MSTP students, provides concrete strategies to manage conflict and navigate leadership transitions in the physician-scientist career path. The curriculum emphasizes both short-term competencies, such as effective participation as a member of a clinical team, and long-term competencies, such as leadership of a research team, division, or department. Our inaugural senior leadership workshop, held in August, 2015, was judged by student participants to be well organized and highly relevant to leadership concepts and skills. It will be offered biennially in our training curriculum for M3 and M4 MSTP students.

Perceptions of neighborhood safety and asthma among children and adolescents in Los Angeles: a multilevel analysis.

Directory of Open Access Journals (Sweden)

Marlene Camacho-Rivera

Full Text Available Research examining the impact of neighborhoods on asthma has shown an increased interest in the role of the psychosocial environment. We examined the associations between various measures of neighborhood safety, individual and family characteristics, and asthma outcomes among children in Los Angeles.Multilevel logistic regression models were used to analyze data on 3,114 children across 65 neighborhoods from Wave 1 of the Los Angeles Family and Neighborhood Survey (2000 to 2002. Primary caregivers reported asthma outcome and all individual covariates; home environmental characteristics were observed by the interviewer.In fully adjusted models, parents who reported their neighborhood fairly safe or somewhat dangerous had lower odds of reported lifetime asthma compared to those who reported their neighborhood completely safe (OR 0.71; 95% CI 0.52-0.96 and OR 0.60; 95% CI 0.42-0.88 respectively. Conversely, parents who reported they could not trust their neighbors to keep their children safe had a nearly 40% increase in lifetime asthma compared to those who reported they could trust their neighbors to keep their children safe (OR 1.39; 95% CI 1.07-1.81.The study demonstrates a complex pattern between various measures of neighborhood safety and asthma and suggests that these relationships may operate differently in Los Angeles. As an increasing proportion of children are growing up in newer Western and Southwestern cities, which have different physical layouts and residential segregation patterns compared to Northeast and Midwestern cities, future studies should continue to examine neighborhood psychosocial stressors and asthma in diverse contexts.

Combination of advanced encryption standard 256 bits with md5 to secure documents on android smartphone

Science.gov (United States)

Pasaribu, Hendra; Sitanggang, Delima; Rizki Damanik, Rudolfo; Rudianto Sitompul, Alex Chandra

2018-04-01

File transfer by using a smartphone has some security issues like data theft by irresponsible parties. To improve the quality of data security systems on smartphones, in this research the integration of AES 256 bit algorithm by using MD5 hashing is proposed. The use of MD5 aims to increase the key strength of the encryption and decryption process of document files. The test results show that the proposed method can increase the key strength of the encryption and decryption process in the document file. Encryption and decryption time by using AES and MD5 combination is faster than using AES only on *.txt file type and reverse results for *.docx, *.xlsx, *.pptx and *.pdf file files.

An Efficient Hybrid DSMC/MD Algorithm for Accurate Modeling of Micro Gas Flows

KAUST Repository

Liang, Tengfei

2013-01-01

Aiming at simulating micro gas flows with accurate boundary conditions, an efficient hybrid algorithmis developed by combining themolecular dynamics (MD) method with the direct simulationMonte Carlo (DSMC)method. The efficiency comes from the fact that theMD method is applied only within the gas-wall interaction layer, characterized by the cut-off distance of the gas-solid interaction potential, to resolve accurately the gas-wall interaction process, while the DSMC method is employed in the remaining portion of the flow field to efficiently simulate rarefied gas transport outside the gas-wall interaction layer. A unique feature about the present scheme is that the coupling between the two methods is realized by matching the molecular velocity distribution function at the DSMC/MD interface, hence there is no need for one-toone mapping between a MD gas molecule and a DSMC simulation particle. Further improvement in efficiency is achieved by taking advantage of gas rarefaction inside the gas-wall interaction layer and by employing the "smart-wall model" proposed by Barisik et al. The developed hybrid algorithm is validated on two classical benchmarks namely 1-D Fourier thermal problem and Couette shear flow problem. Both the accuracy and efficiency of the hybrid algorithm are discussed. As an application, the hybrid algorithm is employed to simulate thermal transpiration coefficient in the free-molecule regime for a system with atomically smooth surface. Result is utilized to validate the coefficients calculated from the pure DSMC simulation with Maxwell and Cercignani-Lampis gas-wall interaction models. ©c 2014 Global-Science Press.

The Convergence of Business and Medicine: A Study of MD/MBA Programs in the United States

Science.gov (United States)

Keogh, Timothy J.; Martin, William Marty

2011-01-01

The purpose of this paper is to identify the convergence of business and medical education and describe the curricula of MD/MBA (Medical Doctor/Master of Business Administration) programs in the US. The focus of this study is to provide a guide to dual MD/MBA programs for physicians, aspiring physicians, policy makers and healthcare organizations.…

Stratigraphic controls on saltwater intrusion in the Dominguez Gap area of coastal Los Angeles

Science.gov (United States)

Edwards, B.D.; Ehman, K.D.; Ponti, D.J.; Reichard, E.G.; Tinsley, J.C.; Rosenbauer, R.J.; Land, M.

2009-01-01

The Los Angeles Basin is a densely populated coastal area that significantly depends on groundwater. A part of this groundwater supply is at risk from saltwater intrusion-the impetus for this study. High-resolution seismic-reflection data collected from the Los Angeles-Long Beach Harbor Complex have been combined with borehole geophysical and descriptive geological data from four nearby ??400-m-deep continuously cored wells and with borehole geophysical data from adjacent water and oil wells to characterize the Pliocene to Holocene stratigraphy of the Dominguez Gap coastal aquifer system. The new data are shown as a north-south, two- dimensional, sequence-stratigraphic model that is compared to existing lithostratigraphic models of the Los Angeles Basin in an attempt to better understand pathways of saltwater intrusion into coastal aquifers. Intrusion of saltwater into the coastal aquifer system generally is attributed to over-pumping that caused the hydraulic gradient to reverse during the mid-1920s. Local water managers have used the existing lithostratigraphic model to site closely spaced injection wells of freshwater (barrier projects) attempting to hydraulically control the saltwater intrusion. Improved understanding of the stratigraphic relationships can guide modifications to barrier design that will allow more efficient operation. Allostratigraphic nomenclature is used to define a new sequence-stratigraphic model for the area because the existing lithostratigraphic correlations that have been used to define aquifer systems are shown not to be time-correlative. The youngest sequence, the Holocene Dominguez sequence, contains the Gaspur aquifer at its base. The Gaspur aquifer is intruded with saltwater and consists of essentially flat-lying gravelly sands deposited by the ancestral Los Angeles River as broad channels that occupied a paleovalley incised into the coastal plain during the last glacio-eustatic highstand. The underlying sequences are deformed into

Remaining recoverable petroleum in giant oil fields of the Los Angeles Basin, southern California

Science.gov (United States)

Gautier, Donald L.; Tennyson, Marilyn E.; Cook, Troy A.; Charpentier, Ronald R.; Klett, Timothy R.

2012-01-01

Using a probabilistic geology-based methodology, a team of U.S. Geological Survey (USGS) scientists recently assessed the remaining recoverable oil in 10 oil fields of the Los Angeles Basin in southern California. The results of the assessment suggest that between 1.4 and 5.6 billion barrels of additional oil could be recovered from those fields with existing technology.

A TLR4/MD2 fusion protein inhibits LPS-induced pro-inflammatory signaling in hepatic stellate cells

International Nuclear Information System (INIS)

Schnabl, Bernd; Brandl, Katharina; Fink, Marina; Gross, Philipp; Taura, Kojiro; Gaebele, Erwin; Hellerbrand, Claus; Falk, Werner

2008-01-01

Activated hepatic stellate cells (HSCs) play a key role in hepatic fibrogenesis. In injured liver they are the main extracellular matrix protein producing cell type and further perpetuate hepatic injury by secretion of pro-inflammatory mediators. Since LPS-mediated signaling through toll-like receptor 4 (TLR4) has been identified as key fibrogenic signal in HSCs we aimed to test TLR4 as potential target of therapy via ligand-binding soluble receptors. Incubation of human HSCs with a fusion protein between the extracellular domain of TLR4 and MD2 which binds LPS inhibited LPS-induced NFκB and JNK activation. TLR4/MD2 abolished LPS-induced secretion of IL-6, IL-8, MCP1, and RANTES in HSCs. In addition, TLR4/MD2 fused to human IgG-Fc neutralized LPS activity. Since TLR4 mutant mice are resistant to liver fibrosis, the TLR4/MD2 soluble receptor might represent a new therapeutic molecule for liver fibrogenesis in vivo

Wettability of graphitic-carbon and silicon surfaces: MD modeling and theoretical analysis

International Nuclear Information System (INIS)

Ramos-Alvarado, Bladimir; Kumar, Satish; Peterson, G. P.

2015-01-01

The wettability of graphitic carbon and silicon surfaces was numerically and theoretically investigated. A multi-response method has been developed for the analysis of conventional molecular dynamics (MD) simulations of droplets wettability. The contact angle and indicators of the quality of the computations are tracked as a function of the data sets analyzed over time. This method of analysis allows accurate calculations of the contact angle obtained from the MD simulations. Analytical models were also developed for the calculation of the work of adhesion using the mean-field theory, accounting for the interfacial entropy changes. A calibration method is proposed to provide better predictions of the respective contact angles under different solid-liquid interaction potentials. Estimations of the binding energy between a water monomer and graphite match those previously reported. In addition, a breakdown in the relationship between the binding energy and the contact angle was observed. The macroscopic contact angles obtained from the MD simulations were found to match those predicted by the mean-field model for graphite under different wettability conditions, as well as the contact angles of Si(100) and Si(111) surfaces. Finally, an assessment of the effect of the Lennard-Jones cutoff radius was conducted to provide guidelines for future comparisons between numerical simulations and analytical models of wettability

75 FR 65512 - Raleigh Film and Television Studios, LLC, Los Angeles, CA; Notice of Affirmative Determination...

Science.gov (United States)

2010-10-25

... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-72,587] Raleigh Film and... (TAA) applicable to workers and former workers of Raleigh Film and Television Studios, LLC, Los Angeles... alleges that the subject firm ``is actively building large film studios in both Budapest, Hungary and...

An apple MYB transcription factor, MdMYB3, is involved in regulation of anthocyanin biosynthesis and flower development.

Science.gov (United States)

Vimolmangkang, Sornkanok; Han, Yuepeng; Wei, Guochao; Korban, Schuyler S

2013-11-07

Red coloration of fruit is an important trait in apple, and it is mainly attributed to the accumulation of anthocyanins, a class of plant flavonoid metabolites. Anthocyanin biosynthesis is genetically determined by structural and regulatory genes. Plant tissue pigmentation patterns are mainly controlled by expression profiles of regulatory genes. Among these regulatory genes are MYB transcription factors (TFs), wherein the class of two-repeats (R2R3) is deemed the largest, and these are associated with the anthocyanin biosynthesis pathway. Although three MdMYB genes, almost identical in nucleotide sequences, have been identified in apple, it is likely that there are other R2R3 MYB TFs that are present in the apple genome that are also involved in the regulation of coloration of red color pigmentation of the skin of apple fruits. In this study, a novel R2R3 MYB gene has been isolated and characterized in apple. This MYB gene is closely related to the Arabidopsis thaliana AtMYB3, and has been designated as MdMYB3. This TF belongs to the subgroup 4 R2R3 family of plant MYB transcription factors. This apple MdMYB3 gene is mapped onto linkage group 15 of the integrated apple genetic map. Transcripts of MdMYB3 are detected in all analyzed tissues including leaves, flowers, and fruits. However, transcripts of MdMYB3 are higher in excocarp of red-skinned apple cultivars than that in yellowish-green skinned apple cultivars. When this gene is ectopically expressed in Nicotiana tabacum cv. Petite Havana SR1, flowers of transgenic tobacco lines carrying MdMYB3 have exhibited increased pigmentation and accumulate higher levels of anthocyanins and flavonols than wild-type flowers. Overexpression of MdMYB3 has resulted in transcriptional activation of several flavonoid pathway genes, including CHS, CHI, UFGT, and FLS. Moreover, peduncles of flowers and styles of pistils of transgenic plants overexpressing MdMYB3 are longer than those of wild-type plants, thus suggesting that this

Integrating Sodium Reduction Strategies in the Procurement Process and Contracting of Food Venues in the County of Los Angeles Government, 2010–2012

Science.gov (United States)

Cummings, Patricia L.; Kuo, Tony; Gase, Lauren N.; Mugavero, Kristy

2015-01-01

Since sodium is ubiquitous in the food supply, recent approaches to sodium reduction have focused on increasing the availability of lower-sodium products through system-level and environmental changes. This article reviews integrated efforts by the Los Angeles County Sodium Reduction Initiative to implement these strategies at food venues in the County of Los Angeles government. The review used mixed methods, including a scan of the literature, key informant interviews, and lessons learned during 2010–2012 to assess program progress. Leveraging technical expertise and shared resources, the initiative strategically incorporated sodium reduction strategies into the overall work plan of a multipartnership food procurement program in Los Angeles County. To date, 3 County departments have incorporated new or updated nutrition requirements that included sodium limits and other strategies. The strategic coupling of sodium reduction to food procurement and general health promotion allowed for simultaneous advancement and acceleration of the County’s sodium reduction agenda. PMID:24322811

Entertainment-Retail Centers in Hong Kong and Los Angeles: Trends and Lessons

OpenAIRE

Clara Irazabal; Surajit Chakravarty

2007-01-01

This paper seeks to answer the question of why Entertainment Retail Centers (ERCs) develop as they do and what we can expect from these centers of consumption in the near future. Beginning with a "network" view of cities, where cities are nodes in an integrated economic system, the paper examines the evolution of and recent trends in the design of Entertainment Retail Centers (ERCs) in Los Angeles and Hong Kong. The analysis is organized along four related themes - land use, transportation, u...

Towards automatic coupling corrections with DOROS BPMs (MD750)

CERN Document Server

Persson, Tobias Hakan Bjorn; Langner, Andy Sven; Lefevre, Thibaut; Maclean, Ewen Hamish; Malina, Lukas; Olexa, Jakub; Skowronski, Piotr Krzysztof; Garcia-Tabares Valdivieso, Ana; Coello De Portugal - Martinez Vazquez, Jaime Maria; Tomas Garcia, Rogelio; CERN. Geneva. ATS Department

2015-01-01

BPMs close to IP1 and IP5 have been equipped with the new DOROS (Diode ORbit OScillation) system which provides precise orbit and turn-by-turn data [1]. In this MD-note we report on the rst measurements with the DOROS system to measure the transverse coupling. Furthermore, we compare the results and the performance of the system to the normal BPMs.

33 CFR 334.155 - Severn River, Naval Station Annapolis, Small Boat Basin, Annapolis, MD; naval restricted area.

Science.gov (United States)

2010-07-01

... Annapolis, Small Boat Basin, Annapolis, MD; naval restricted area. 334.155 Section 334.155 Navigation and... RESTRICTED AREA REGULATIONS § 334.155 Severn River, Naval Station Annapolis, Small Boat Basin, Annapolis, MD; naval restricted area. (a) The area. The waters within the Naval Station Annapolis small boat basin and...

76 FR 51887 - Safety Zone; Patuxent River, Patuxent River, MD

Science.gov (United States)

2011-08-19

...-AA00 Safety Zone; Patuxent River, Patuxent River, MD AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a temporary safety zone during the ``NAS Patuxent River... held over certain waters of the Patuxent River adjacent to Patuxent River, Maryland from September 1...

Measurements and predictors of on-road ultrafine particle concentrations and associated pollutants in Los Angeles

Energy Technology Data Exchange (ETDEWEB)

Fruin, S. [California Air Resources Board, Sacramento (United States); University of Southern California, Los Angeles (United States). Keck School of Medicine, Department of Preventive Medicine; Westerdahl, D.; Sax, T. [California Air Resources Board, Sacramento (United States); Sioutas, C. [University of Southern California, Los Angeles (United States). Civil and Environmental Engineering; Fine, P.M. [University of Southern California, Los Angeles (United States). Civil and Environmental Engineering; South Coast Air Quality Management District, Diamond Bar, CA (United States)

2008-01-15

Motor vehicles are the dominant source of oxides of nitrogen (NO{sub x}), particulate matter(PM), and certain air toxics (e.g., benzene, 1,3-butadiene) in urban areas. On roadways, motor vehicle-related pollutant concentrations are typically many times higher than ambient concentrations. Due to high air exchange rates typical of moving vehicles, this makes time spent in vehicles on roadways a major source of exposure. This paper presents on-road measurements for Los Angeles freeways and arterial roads taken from a zero-emission electric vehicle outfitted with real-time instruments. The objective was to characterize air pollutant concentrations on roadways and identify the factors associated with the highest concentrations. Our analysis demonstrated that on freeways, concentrations of ultrafine particles (UFPs), black carbon, nitric oxide, and PM-bound polycyclic aromatic hydrocarbons (PM-PAH) are generated primarily by diesel-powered vehicles, despite the relatively low fraction ({approx}6%) of diesel-powered vehicles on Los Angeles freeways. However, UFP concentrations on arterial roads appeared to be driven primarily by proximity to gasoline-powered vehicles undergoing hard accelerations. Concentrations were roughly one-third of those on freeways. By using a multiple regression model for the freeway measurements, we were able to explain 60-70% of the variability in concentrations of UFP, black carbon, nitric oxide, and PM-PAH using measures of diesel truck density and hour of day (as an indicator of wind speed). Freeway concentrations of these pollutants were also well correlated wth readily available annual average daily truck counts, potentially allowing improved population exposure estimates for epidemiology studies. Based on these roadway measurements and average driving time, it appears that 33-45% of total UFP exposure for Los Angeles residents occurs due to time spent traveling in vehicles. (author)

Measurements and predictors of on-road ultrafine particle concentrations and associated pollutants in Los Angeles

International Nuclear Information System (INIS)

Fruin, S.; Sioutas, C.

2008-01-01

Motor vehicles are the dominant source of oxides of nitrogen (NO x ), particulate matter(PM), and certain air toxics (e.g., benzene, 1,3-butadiene) in urban areas. On roadways, motor vehicle-related pollutant concentrations are typically many times higher than ambient concentrations. Due to high air exchange rates typical of moving vehicles, this makes time spent in vehicles on roadways a major source of exposure. This paper presents on-road measurements for Los Angeles freeways and arterial roads taken from a zero-emission electric vehicle outfitted with real-time instruments. The objective was to characterize air pollutant concentrations on roadways and identify the factors associated with the highest concentrations. Our analysis demonstrated that on freeways, concentrations of ultrafine particles (UFPs), black carbon, nitric oxide, and PM-bound polycyclic aromatic hydrocarbons (PM-PAH) are generated primarily by diesel-powered vehicles, despite the relatively low fraction (∼6%) of diesel-powered vehicles on Los Angeles freeways. However, UFP concentrations on arterial roads appeared to be driven primarily by proximity to gasoline-powered vehicles undergoing hard accelerations. Concentrations were roughly one-third of those on freeways. By using a multiple regression model for the freeway measurements, we were able to explain 60-70% of the variability in concentrations of UFP, black carbon, nitric oxide, and PM-PAH using measures of diesel truck density and hour of day (as an indicator of wind speed). Freeway concentrations of these pollutants were also well correlated wth readily available annual average daily truck counts, potentially allowing improved population exposure estimates for epidemiology studies. Based on these roadway measurements and average driving time, it appears that 33-45% of total UFP exposure for Los Angeles residents occurs due to time spent traveling in vehicles. (author)

Measurements and predictors of on-road ultrafine particle concentrations and associated pollutants in Los Angeles

Science.gov (United States)

Fruin, S.; Westerdahl, D.; Sax, T.; Sioutas, C.; Fine, P. M.

Motor vehicles are the dominant source of oxides of nitrogen (NO x), particulate matter (PM), and certain air toxics (e.g., benzene, 1,3-butadiene) in urban areas. On roadways, motor vehicle-related pollutant concentrations are typically many times higher than ambient concentrations. Due to high air exchange rates typical of moving vehicles, this makes time spent in vehicles on roadways a major source of exposure. This paper presents on-road measurements for Los Angeles freeways and arterial roads taken from a zero-emission electric vehicle outfitted with real-time instruments. The objective was to characterize air pollutant concentrations on roadways and identify the factors associated with the highest concentrations. Our analysis demonstrated that on freeways, concentrations of ultrafine particles (UFPs), black carbon, nitric oxide, and PM-bound polycyclic aromatic hydrocarbons (PM-PAH) are generated primarily by diesel-powered vehicles, despite the relatively low fraction (˜6%) of diesel-powered vehicles on Los Angeles freeways. However, UFP concentrations on arterial roads appeared to be driven primarily by proximity to gasoline-powered vehicles undergoing hard accelerations. Concentrations were roughly one-third of those on freeways. By using a multiple regression model for the freeway measurements, we were able to explain 60-70% of the variability in concentrations of UFP, black carbon, nitric oxide, and PM-PAH using measures of diesel truck density and hour of day (as an indicator of wind speed). Freeway concentrations of these pollutants were also well correlated with readily available annual average daily truck counts, potentially allowing improved population exposure estimates for epidemiology studies. Based on these roadway measurements and average driving time, it appears that 33-45% of total UFP exposure for Los Angeles residents occurs due to time spent traveling in vehicles.

Cavity Voltage Phase Modulation MD

CERN Document Server

Mastoridis, Themistoklis; Molendijk, John; Timko, Helga; CERN. Geneva. ATS Department

2016-01-01

The LHC RF/LLRF system is currently configured for extremely stable RF voltage to minimize transient beam loading effects. The present scheme cannot be extended beyond nominal beam current since the demanded power would exceed the peak klystron power and lead to saturation. A new scheme has therefore been proposed: for beam currents above nominal (and possibly earlier), the cavity phase modulation by the beam will not be corrected (transient beam loading), but the strong RF feedback and One-Turn Delay feedback will still be active for loop and beam stability in physics. To achieve this, the voltage set point will be adapted for each bunch. The goal of this MD was to test a new algorithm that would adjust the voltage set point to achieve the cavity phase modulation that would minimize klystron forward power.

Verina Morton Jones, MD.

Science.gov (United States)

Rishworth, Susan K

2012-01-01

The purpose of this historical article is to demonstrate, as the biography of Verina Morton Jones, MD, is uncovered, the difficulties inherent in researching original source material on the lives of 19th- and early 20th-century African American physicians as well as the great benefits derived from doing this research. The procedures used include basic archival research and close examination of published materials about her in the past, in conjunction with oral history. Original correspondence from Dr Morton Jones to her niece and nephew is used to illustrate events in her life and the thoughts and attitudes she expressed. Some of these thoughts and attitudes reflect those current situations in which African Americans found themselves, and others are quite unique, no doubt owing to her privileged position in the African American community. The principle conclusions reached include the great benefits derived from doing this kind of research, as difficult and time-consuming as that may be, with the enhanced knowledge and appreciation of the heritage of African American physicians, and insights into American social history during this period.

ADT fast losses MD

CERN Document Server

Priebe, A; Dehning, B; Redaelli, S; Salvachua Ferrando, BM; Sapinski, M; Solfaroli Camillocci, M; Valuch, D

2013-01-01

The fast beam losses in the order of 1 ms are expected to be a potential major luminosity limitation for higher beam energies after the LHC long shutdown (LS1). Therefore a Quench Test is planned in the winter 2013 to estimate the quench limit in this timescale and revise the current models. This experiment was devoted to determination the LHC Transverse Damper (ADT) as a system for fast losses induction. A non-standard operation of the ADT was used to develop the beam oscillation instead of suppressing them. The sign flip method had allowed us to create the fast losses within several LHC turns at 450 GeV during the previous test (26th March 2012). Thus, the ADT could be potentially used for the studies of the UFO ("Unidentied Falling Object") impact on the cold magnets. Verification of the system capability and investigations of the disturbed beam properties were the main objectives of this MD. During the experiment, the pilot bunches of proton beam were excited independently in the horizontal and vertical ...

LHC MD 652: Coupled-Bunch Instability with Smaller Emittance (all HOMs)

CERN Document Server

AUTHOR|(CDS)2081238; Timko, Helga; CERN. Geneva. ATS Department

2017-01-01

The aim of the MD was to measure the coupled-bunch stability from all HOM impedances, with a reduced longitudinal emittance in order to explore the HL-LHC conditions. The acceleration ramp was performed with the nominal beams of 2016, but a reduced target bunch length and RF voltage. With this reduced emittance, the beam remained close but above the single-bunch stability threshold. No coupled-bunch oscillations were observed, so we can conclude that the stability threshold for coupled-bunch instability is not lower than the single-bunch threshold. An interesting observation in the MD was the long-lasting injection oscillations, whose traces can still be seen at arrival to flat top; in agreement with observations in earlier MDs. The measurements took place between 28th October 20:00 and 29th October 05:10.

DMPD: Innate recognition of lipopolysaccharide by Toll-like receptor 4-MD-2. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 15051069 Innate recognition of lipopolysaccharide by Toll-like receptor 4-MD-2. Miy...ake K. Trends Microbiol. 2004 Apr;12(4):186-92. (.png) (.svg) (.html) (.csml) Show Innate recognition of lip...opolysaccharide by Toll-like receptor 4-MD-2. PubmedID 15051069 Title Innate recognition of lipopolysacchari

The PST Project, Willie Herron's Street Mural Asco East of No West (2011 and the Mural Remix Tour: Power Relations on the Los Angeles Art Scene

Directory of Open Access Journals (Sweden)

Eva Zetterman

2014-06-01

Full Text Available This article departs from the huge art-curating project Pacific Standard Time: Art in L.A., 1945-1980, a Getty funded initiative running in Southern California from October 2011 to April 2012 with a collaboration of more than sixty cultural institutions coming together to celebrate the birth of the L.A. art scene. One of the Pacific Standard Time (PST exhibitions was Asco: Elite of the Obscure, A Retrospective, 1972-1987, running from September to December 2011 at the Los Angeles County Museum of Art (LACMA. This was the first retrospective of a conceptual performance group of Chicanos from East Los Angeles, who from the early 1970s to the mid 1980s acted out critical interventions in the politically contested urban space of Los Angles. In conjunction with the Asco retrospective at LACMA, the Getty Foundation co-sponsored a new street mural by the Chicano artist Willie Herron, paying homage to his years in the performance group Asco. The PST exhibition program also included so-called Mural Remix Tours, taking fine art audiences from LACMA to Herron's place-specific new mural in City Terrace in East Los Angeles. This article analyze the inclusion in the PST project of Herron's site-specific mural in City Terrace and the Mural Remix Tours to East Los Angeles with regard to the power relations of fine art and critical subculture, center and periphery, the mainstream and the marginal. As a physical monument dependent on a heavy sense of the past, Herron's new mural, titled Asco: East of No West, transforms the physical and social environment of City Terrace, changing its public space into an official place of memory. At the same time, as an art historical monument officially added to the civic map of Los Angeles, the mural becomes a permanent reminder of the segregation patterns that still exist in the urban space of Los Angeles.

Full-Scale Crash Test of an MD-500 Helicopter

Science.gov (United States)

Littell, Justin

2011-01-01

A full-scale crash test was successfully conducted in March 2010 of an MD-500 helicopter at NASA Langley Research Center s Landing and Impact Research Facility. The reasons for conducting this test were threefold: 1 To generate data to be used with finite element computer modeling efforts, 2 To study the crashworthiness features typically associated with a small representative helicopter, and 3 To compare aircraft response to data collected from a previously conducted MD-500 crash test, which included an externally deployable energy absorbing (DEA) concept. Instrumentation on the airframe included accelerometers on various structural components of the airframe; and strain gages on keel beams, skid gear and portions of the skin. Three Anthropomorphic Test Devices and a specialized Human Surrogate Torso Model were also onboard to collect occupant loads for evaluation with common injury risk criteria. This paper presents background and results from this crash test conducted without the DEA concept. These results showed accelerations of approximately 30 to 50 g on the airframe at various locations, little energy attenuation through the airframe, and moderate to high probability of occupant injury for a variety of injury criteria.

76 FR 20034 - Calvin Ramsey, M.D.; Revocation of Registration

Science.gov (United States)

2011-04-11

... DEPARTMENT OF JUSTICE Drug Enforcement Administration [Docket No. 10-25] Calvin Ramsey, M.D.; Revocation of Registration On December 18, 2009, the Deputy Assistant Administrator, Office of Diversion... constitutional right to appointed counsel in a proceeding under 21 U.S.C. 824(a). See Goldberg v. Kelly, 397 U.S...

Estimating spatially and temporally varying recharge and runoff from precipitation and urban irrigation in the Los Angeles Basin, California

Science.gov (United States)

Hevesi, Joseph A.; Johnson, Tyler D.

2016-10-17

A daily precipitation-runoff model, referred to as the Los Angeles Basin watershed model (LABWM), was used to estimate recharge and runoff for a 5,047 square kilometer study area that included the greater Los Angeles area and all surface-water drainages potentially contributing recharge to a 1,450 square kilometer groundwater-study area underlying the greater Los Angeles area, referred to as the Los Angeles groundwater-study area. The recharge estimates for the Los Angeles groundwater-study area included spatially distributed recharge in response to the infiltration of precipitation, runoff, and urban irrigation, as well as mountain-front recharge from surface-water drainages bordering the groundwater-study area. The recharge and runoff estimates incorporated a new method for estimating urban irrigation, consisting of residential and commercial landscape watering, based on land use and the percentage of pervious land area.The LABWM used a 201.17-meter gridded discretization of the study area to represent spatially distributed climate and watershed characteristics affecting the surface and shallow sub-surface hydrology for the Los Angeles groundwater study area. Climate data from a local network of 201 monitoring sites and published maps of 30-year-average monthly precipitation and maximum and minimum air temperature were used to develop the climate inputs for the LABWM. Published maps of land use, land cover, soils, vegetation, and surficial geology were used to represent the physical characteristics of the LABWM area. The LABWM was calibrated to available streamflow records at six streamflow-gaging stations.Model results for a 100-year target-simulation period, from water years 1915 through 2014, were used to quantify and evaluate the spatial and temporal variability of water-budget components, including evapotranspiration (ET), recharge, and runoff. The largest outflow of water from the LABWM was ET; the 100-year average ET rate of 362 millimeters per year (mm

The Impacts of Urbanization on Meteorology and Air Quality in the Los Angeles Basin

Science.gov (United States)

Li, Y.; Zhang, J.; Sailor, D.; Ban-Weiss, G. A.

2017-12-01

Urbanization has a profound influence on regional meteorology in mega cities like Los Angeles. This influence is driven by changes in land surface physical properties and urban processes, and their corresponding influence on surface-atmosphere coupling. Changes in meteorology from urbanization in turn influences air quality through weather-dependent chemical reaction, pollutant dispersion, etc. Hence, a real-world representation of the urban land surface properties and urban processes should be accurately resolved in regional climate-chemistry models for better understanding the role of urbanization on changing urban meteorology and associated pollutant dynamics. By incorporating high-resolution land surface data, previous research has improved model-observation comparisons of meteorology in urban areas including the Los Angeles basin, and indicated that historical urbanization has increased urban temperatures and altered wind flows significantly. However, the impact of urban expansion on air quality has been less studied. Thus, in this study, we aim to evaluate the effectiveness of resolving high-resolution heterogeneity in urban land surface properties and processes for regional weather and pollutant concentration predictions. We coupled the Weather Research and Forecasting model with Chemistry to the single-layer Urban Canopy Model to simulate a typical summer period in year 2012 for Southern California. Land cover type and urban fraction were determined from National Land Cover Data. MODIS observations were used to determine satellite-derived albedo, green vegetation fraction, and leaf area index. Urban morphology was determined from GIS datasets of 3D building geometries. An urban irrigation scheme was also implemented in the model. Our results show that the improved model captures the diurnal cycle of 2m air temperature (T2) and Ozone (O3) concentrations. However, it tends to overestimate wind speed and underestimate T2, which leads to an underestimation of O

The Devil and its multiple images in illuminations of the Devorous Monster and the Falling Angel (15th century: some examples

Directory of Open Access Journals (Sweden)

Adriana Maria de Souza Zierer

2016-09-01

Full Text Available This article conducted an analysis on the multiple images of the Devil, based on three illuminations of the 15th century. It is possible to observe the following elements: 1-the evil one as a head, with a huge open mouth, known as the Hellmouth; 2-as a human being, but with animalistic characteristics, carrying claws, the tail, among other things, still with devouring aspect; 3-represented in beautiful shape, as the rebel angel, Lucifer, expelled from heaven by God. Three images were analyzed; one from the narrative Vision of Tondal, which it is represented as the Beast Acheron, in the form of Hellmouth, and two images of the book Les Très Riches Heures of the Duc de Berry (The Very Rich Hours of the Duke of Berry, when figured with animalistic features in the image entitled "Inferno" (fl.108r and with his angelic features in "The fall of the Rebel Angels" (fl. 64v. In the last two illuminations the Devil presents ruler of Hell elements. Moreover, it is clear that this has ambiguous features in Christian imagination.

In-situ Air Temperature and Relative Humidity in Greenbelt, MD, 2013-2015

Data.gov (United States)

National Aeronautics and Space Administration — This data set describes the temperature and relative humidity at 12 locations around Goddard Space Flight Center in Greenbelt MD at 15 minute intervals between...

Metabolic engineering of apple by overexpression of the MdMyb10 gene

Directory of Open Access Journals (Sweden)

Khaled A.L. Rihani

2017-06-01

In the present study, the flavonoid pathway was successfully modified in apple by overexpressing the MdMyb10 transcription factor to validate the hypothesis of increased effect on plant disease resistance.

Comparison of two methods for estimating the number of undocumented Mexican adults in Los Angeles County.

Science.gov (United States)

Heer, D M; Passel, J F

1987-01-01

This article compares 2 different methods for estimating the number of undocumented Mexican adults in Los Angeles County. The 1st method, the survey-based method, uses a combination of 1980 census data and the results of a survey conducted in Los Angeles County in 1980 and 1981. A sample was selected from babies born in Los Angeles County who had a mother or father of Mexican origin. The survey included questions about the legal status of the baby's parents and certain other relatives. The resulting estimates of undocumented Mexican immigrants are for males aged 18-44 and females aged 18-39. The 2nd method, the residual method, involves comparison of census figures for aliens counted with estimates of legally-resident aliens developed principally with data from the Immigration and Naturalization Service (INS). For this study, estimates by age, sex, and period of entry were produced for persons born in Mexico and living in Los Angeles County. The results of this research indicate that it is possible to measure undocumented immigration with different techniques, yet obtain results that are similar. Both techniques presented here are limited in that they represent estimates of undocumented aliens based on the 1980 census. The number of additional undocumented aliens not counted remains a subject of conjecture. The fact that the proportions undocumented shown in the survey (228,700) are quite similar to the residual estimates (317,800) suggests that the number of undocumented aliens not counted in the census may not be an extremely large fraction of the undocumented population. The survey-based estimates have some significant advantages over the residual estimates. The survey provides tabulations of the undocumented population by characteristics other than the limited demographic information provided by the residual technique. On the other hand, the survey-based estimates require that a survey be conducted and, if national or regional estimates are called for, they may

Vocalizing the Angels of Mons: Audio Dramas as Propaganda in the Great War of 1914 to 1918

Directory of Open Access Journals (Sweden)

Tim Crook

2014-05-01

Full Text Available Sound drama production prior to the onset of the “Radio Age” underwent a pioneering development during the Great War. This was achieved by the making, publication and distribution of short audio dramas acted with sound effects and music in front of early microphones and released in the form of 78 rpm phonograph discs. Entertaining storytelling through dramatic performance was mobilized for the purposes of improving recruitment and disseminating patriotic endorsement recordings. This article focuses on the sound dramatization of the myth of “The Angels of Mons” released by Regal in 1915. The recording is examined as a text for its significance in terms of propaganda, style of audio-drama, and any cultural role it may have played in the media of the First World War. The Regal disc was an example of what was described at the time as “descriptive sketches.” This article explores why a sound phonograph was used to dramatize the myth that angels intervened to assist the British Expeditionary Force to resist the German Army invading France through Belgium in 1914. A number of historians have discussed the First World War as being a theatre for the first modern media war, in which the process of propaganda was modernized. To what extent does “The Angels of Mons” phonograph and the genre of descriptive sketches support this analysis? Does this short sound drama play have any relevance to the cultural phenomena of spiritualism, modernism and patriotic Christianity identified as being important during the Great War period?

Misuse of prescription and illicit drugs among high-risk young adults in Los Angeles and New York

Directory of Open Access Journals (Sweden)

Stephen E. Lankenau

2012-02-01

Full Text Available Background. Prescription drug misuse among young adults is increasingly viewed as a public health concern, yet most research has focused on student populations and excluded high-risk groups. Furthermore, research on populations who report recent prescription drug misuse is limited. This study examined patterns of prescription drug misuse among high-risk young adults in Los Angeles (LA and New York (NY, which represent different local markets for illicit and prescription drugs. Design and Methods. Between 2009 and 2011, 596 young adults (16 to 25 years old who had misused prescription drugs within the past 90 days were interviewed in Los Angeles and New York. Sampling was stratified to enroll three groups of high-risk young adults: injection drug users (IDUs; homeless persons; and polydrug users. Results. In both sites, lifetime history of receiving a prescription for an opioid, tranquilizer, or stimulant was high and commonly preceded misuse. Moreover, initiation of opioids occurred before heroin and initiation of prescription stimulants happened prior to illicit stimulants. NY participants more frequently misused oxycodone, heroin, and cocaine, and LA participants more frequently misused codeine, marijuana, and methamphetamine. Combining prescription and illicit drugs during drug using events was commonly reported in both sites. Opioids and tranquilizers were used as substitutes for other drugs, e.g., heroin, when these drugs were not available. Conclusion. Patterns of drug use among high-risk young adults in Los Angeles and New York appear to be linked to differences in local markets in each city for illicit drugs and diverted prescription drugs.

76 FR 14698 - Raleigh Film and Television Studios, LLC, Los Angeles, CA; Notice of Negative Determination on...

Science.gov (United States)

2011-03-17

... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-72,587] Raleigh Film and... Reconsideration for the workers and former workers of Raleigh Film and Television Studios, LLC, Los Angeles... for reconsideration alleges that the subject firm is building large film studios in foreign countries...

76 FR 71369 - Robert G. Crummie, M.D.; Decision and Order

Science.gov (United States)

2011-11-17

... agencies to perform meaningless tasks. See Layfe Robert Anthony, M.D., 67 FR 35582 (DEA 2002); Michael G.... Kirk v. Mullen, 749 F.2d 297 (6th Cir. 1984); Puerto Rico Aqueduct and Sewer Auth. v. EPA, 35 F.3d 600...

Climate Change and Adaptation Planning on the Los Angeles Aqueduct

Science.gov (United States)

Roy, S. B.; Bales, R. C.; Costa-Cabral, M. C.; Chen, L.; Maurer, E. P.; Miller, N. L.; Mills, W. B.

2009-12-01

This study provides an assessment of the potential impacts of climate change on the Eastern Sierra Nevada snowpack and snowmelt timing, using a combination of empirical (i.e., data-based) models, and computer simulation models forced by GCM-projected 21st century climatology (IPCC 2007 AR4 projections). Precipitation from the Eastern Sierra Nevada is one of the main water sources for Los Angeles' more than 4 million people - a source whose future availability is critical to the city's growing population and large economy. Precipitation in the region falls mostly in winter and is stored in the large natural reservoir that is the snowpack. Meltwater from the Eastern Sierra is delivered to the city by the 340-mile long Los Angeles Aqueducts. The analysis is focused on the nature of the impact to the LAA water supplies over the 21st century due to potential climate change, including volume of precipitation, the mix of snowfall and rainfall, shifts in the timing of runoff, interannual variability and multi-year droughts. These impacts further affect the adequacy of seasonal and annual carryover water storage, and potentially water treatment. Most of the snow in the 10,000 km^2 Mono-Owens basins that feed the LAA occurs in a relatively narrow, 10-20 km wide, high-elevation band on the steep slopes of 20 smaller basins whose streams drain into the Owens River and thence LAA. Extending over 240 km in the north-south direction, these basins present special challenges for estimating snowpack amounts and downscaling climate-model data. In addition, there are few meteorological stations and snow measurements in the snow-producing parts of the basins to drive physically based hydrologic modeling.

Sob a sombra de Carmen Miranda e do carnaval: brasileiras em Los Angeles Under the shadow of Carmen Miranda and carnival: brazilian women in Los Angeles

Directory of Open Access Journals (Sweden)

Bernadete Beserra

2007-06-01

Full Text Available Neste artigo, analiso como brasileiras de classes média e média alta em Los Angeles lidam com o fenômeno da exotização das suas imagens. Observo que, embora originalmente articuladas a partir de Hollywood (Carmen Miranda nos limites da hierarquia entre as nações e do colonialismo, essas imagens são hoje alimentadas e recriadas também pelos próprios brasileiros. Uma das idéias centrais que defendo aqui é que embora tais imagens inicialmente restrinjam a ação das brasileiras, uma vez que sempre impõem o diálogo com os seus conteúdos, elas não o fazem permanentemente, ou seja, no processo de integração há espaço para a negociação de outras imagens e conteúdos e isto depende de fatores que vão além da exotização em si.This article discusses how middle and upper-middle class Brazilian women deal with their exoticized images in Los Angeles. It points out that although originally articulated from Hollywood (Carmen Miranda, within the limits of the hierarchy of nations and colonialism, today these images are also fed and recreated by Brazilians. One of the central ideas presented is that, despite constraining the movements and actions of the women, imposing on them the need to dialogue with their content, these exotic images do not do it permanently. In other words, in the process of integration, there is always room for negotiation of other images and contents that depend on factor other than exoticization itself.

2017 Sustainable LA Environmental Report Card for Los Angeles County: Energy & Air Quality

OpenAIRE

Federico, Felicia; Rauser, Casandra; Gold, Mark

2017-01-01

The 2017 Sustainable LA Environmental Report Card (ERC) for Los Angeles County (LA County) on Energy and Air Quality offers an in-depth look at the region’s sustainability efforts focusing on the energy we use, greenhouse gas emissions, and the air we breathe. The LA County Environmental Report Card is the only comprehensive environmental report card for a megacity in the world. This ERC assesses 21 indicators that fall into five categories: Stationary Energy Use; Transportation; Renewable En...

Shelter from the Storm: Optimizing Distribution of Bus Stop Shelters in Los Angeles

OpenAIRE

Law, Philip; Taylor, Brian D.

2010-01-01

The functions of bus stop shelters and factors affecting their placement at stops in transit systems are analyzed. Drawing on information from a variety of sources, current shelter placement policy in Los Angeles was found to be guided principally by the revenue-generating potential of shelter advertisements, secondarily by political concerns over geographic equity, and only peripherally on the basis of bus stop use. Using data on shelter and stop locations, boardings, and headways, a methodo...

PyContact: Rapid, Customizable, and Visual Analysis of Noncovalent Interactions in MD Simulations.

Science.gov (United States)

Scheurer, Maximilian; Rodenkirch, Peter; Siggel, Marc; Bernardi, Rafael C; Schulten, Klaus; Tajkhorshid, Emad; Rudack, Till

2018-02-06

Molecular dynamics (MD) simulations have become ubiquitous in all areas of life sciences. The size and model complexity of MD simulations are rapidly growing along with increasing computing power and improved algorithms. This growth has led to the production of a large amount of simulation data that need to be filtered for relevant information to address specific biomedical and biochemical questions. One of the most relevant molecular properties that can be investigated by all-atom MD simulations is the time-dependent evolution of the complex noncovalent interaction networks governing such fundamental aspects as molecular recognition, binding strength, and mechanical and structural stability. Extracting, evaluating, and visualizing noncovalent interactions is a key task in the daily work of structural biologists. We have developed PyContact, an easy-to-use, highly flexible, and intuitive graphical user interface-based application, designed to provide a toolkit to investigate biomolecular interactions in MD trajectories. PyContact is designed to facilitate this task by enabling identification of relevant noncovalent interactions in a comprehensible manner. The implementation of PyContact as a standalone application enables rapid analysis and data visualization without any additional programming requirements, and also preserves full in-program customization and extension capabilities for advanced users. The statistical analysis representation is interactively combined with full mapping of the results on the molecular system through the synergistic connection between PyContact and VMD. We showcase the capabilities and scientific significance of PyContact by analyzing and visualizing in great detail the noncovalent interactions underlying the ion permeation pathway of the human P2X 3 receptor. As a second application, we examine the protein-protein interaction network of the mechanically ultrastable cohesin-dockering complex. Copyright © 2017 Biophysical Society

Vegetation composition and altitudinal distribution of Andean rain forests in El Angel and Guandera reserves, northern Ecuador

NARCIS (Netherlands)

Moscol Olivera, M.C.; Cleef, A.M.

2009-01-01

Patterns of vascular plant species composition and structure of the remaining rain forest of the Andean Cordillera in northern Ecuador were studied in two reserves: Guandera and El Angel. Thirty three plots located between 3300 and 3700 in were examined along two altitudinal transects crossing the

TREE-RING INDICES AND ISOTOPE SIGNATURES OF PINUS PONDEROSA RELATED TO HISTORIC OZONE CHANGES OUTSIDE LOS ANGELES

Science.gov (United States)

Ozone concentrations in the Los Angeles (LA) basin were at historic highs in the late 1970s. Since that time Clean Air regulations have helped lower ozone, but little is known of the long-term vegetation responses. Extensive research has used tree-ring indices together with the...

Vegetation composition and altitudinal distribution of Andean rain forests in El Angel and Guandera reserves, northern Ecuador

NARCIS (Netherlands)

Moscol Olivera, M.C.; Cleef, A.M.

2009-01-01

Patterns of vascular plant species composition and structure of the remaining rain forest of the Andean Cordillera in northern Ecuador were studied in two reserves: Guandera and El Angel. Thirty three plots located between 3300 and 3700 m were examined along two altitudinal transects crossing the

Preliminary Report Regarding State Allocation Board Funding of the Los Angeles Unified School District's Belmont Learning Complex.

Science.gov (United States)

Armoudian, Maria; Carman, Georgann; Havan, Artineh; Heron, Frank

A preliminary report of the California Legislature's Joint Legislative Audit Committee presents findings on the construction team selection process for the Los Angeles Unified School District's (LAUSD's) Belmont Learning Complex. Evidence reveals a seriously flawed process that directly conflicted with existing law and practice. The report…

A dsRNA-binding protein MdDRB1 associated with miRNA biogenesis modifies adventitious rooting and tree architecture in apple.

Science.gov (United States)

You, Chun-Xiang; Zhao, Qiang; Wang, Xiao-Fei; Xie, Xing-Bin; Feng, Xiao-Ming; Zhao, Ling-Ling; Shu, Huai-Rui; Hao, Yu-Jin

2014-02-01

Although numerous miRNAs have been already isolated from fruit trees, knowledge about miRNA biogenesis is largely unknown in fruit trees. Double-strand RNA-binding (DRB) protein plays an important role in miRNA processing and maturation; however, its role in the regulation of economically important traits is not clear yet in fruit trees. EST blast and RACE amplification were performed to isolate apple MdDRB1 gene. Following expression analysis, RNA binding and protein interaction assays, MdDRB1 was transformed into apple callus and in vitro tissue cultures to characterize the functions of MdDRB1 in miRNA biogenesis, adventitious rooting, leaf development and tree growth habit. MdDRB1 contained two highly conserved DRB domains. Its transcripts existed in all tissues tested and are induced by hormones. It bound to double-strand RNAs and interacted with AtDCL1 (Dicer-Like 1) and MdDCL1. Chip assay indicated its role in miRNA biogenesis. Transgenic analysis showed that MdDRB1 controls adventitious rooting, leaf curvature and tree architecture by modulating the accumulation of miRNAs and the transcript levels of miRNA target genes. Our results demonstrated that MdDRB1 functions in the miRNA biogenesis in a conserved way and that it is a master regulator in the formation of economically important traits in fruit trees. © 2013 Society for Experimental Biology, Association of Applied Biologists and John Wiley & Sons Ltd.

A comparative study of Message Digest 5(MD5) and SHA256 algorithm

Science.gov (United States)

Rachmawati, D.; Tarigan, J. T.; Ginting, A. B. C.

2018-03-01

The document is a collection of written or printed data containing information. The more rapid advancement of technology, the integrity of a document should be kept. Because of the nature of an open document means the document contents can be read and modified by many parties so that the integrity of the information as a content of the document is not preserved. To maintain the integrity of the data, it needs to create a mechanism which is called a digital signature. A digital signature is a specific code which is generated from the function of producing a digital signature. One of the algorithms that used to create the digital signature is a hash function. There are many hash functions. Two of them are message digest 5 (MD5) and SHA256. Those both algorithms certainly have its advantages and disadvantages of each. The purpose of this research is to determine the algorithm which is better. The parameters which used to compare that two algorithms are the running time and complexity. The research results obtained from the complexity of the Algorithms MD5 and SHA256 is the same, i.e., ⊖ (N), but regarding the speed is obtained that MD5 is better compared to SHA256.

75 FR 24774 - Fairmount Bank, Baltimore, MD; Approval of Conversion Application

Science.gov (United States)

2010-05-05

... DEPARTMENT OF THE TREASURY Office of Thrift Supervision [AC-36 OTS Nos. 08193 and H4677] Fairmount Bank, Baltimore, MD; Approval of Conversion Application Notice is hereby given that on April 15, 2010, the Office of Thrift Supervision approved the application of Fairmount Bank, Baltimore, Maryland, to...

76 FR 65118 - Drawbridge Operation Regulation; Bear Creek, Sparrows Point, MD

Science.gov (United States)

2011-10-20

...-AA09 Drawbridge Operation Regulation; Bear Creek, Sparrows Point, MD AGENCY: Coast Guard, DHS. ACTION... regulation. The Baltimore County Revenue Authority (Dundalk Avenue) highway toll drawbridge across Bear Creek... applicable or necessary. Basis and Purpose The drawbridge across Bear Creek, mile 1.5 was removed and...

Portfolio District Reform Meets School Turnaround: Early Implementation Findings from the Los Angeles Public School Choice Initiative

Science.gov (United States)

Marsh, Julie A.; Strunk, Katharine O.; Bush, Susan

2013-01-01

Purpose: Despite the popularity of school "turnaround" and "portfolio district" management as solutions to low performance, there has been limited research on these strategies. The purpose of this paper is to address this gap by exploring the strategic case of Los Angeles Unified School District's Public School Choice…

A Comparison of the American Society of Cataract and Refractive Surgery post-myopic LASIK/PRK Intraocular Lens (IOL calculator and the Ocular MD IOL calculator

Directory of Open Access Journals (Sweden)

Hsu M

2011-09-01

Full Text Available David L DeMill1, Majid Moshirfar1, Marcus C Neuffer1, Maylon Hsu1, Shameema Sikder21John A Moran Eye Center, University of Utah, Salt Lake City, UT, USA; 2Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USABackground: To compare the average values of the American Society of Cataract and Refractive Surgery (ASCRS and Ocular MD intraocular lens (IOL calculators to assess their accuracy in predicting IOL power in patients with prior laser-in-situ keratomileusis (LASIK or photorefractive keratectomy.Methods: In this retrospective study, data from 21 eyes with previous LASIK or photorefractive keratectomy for myopia and subsequent cataract surgery was used in an IOL calculator comparison. The predicted IOL powers of the Ocular MD SRK/T, Ocular MD Haigis, and ASCRS averages were compared. The Ocular MD average (composed of an average of Ocular MD SRK/T and Ocular MD Haigis and the all calculator average (composed of an average of Ocular MD SRK/T, Ocular MD Haigis, and ASCRS were also compared. Primary outcome measures were mean arithmetic and absolute IOL prediction error, variance in mean arithmetic IOL prediction error, and the percentage of eyes within ±0.50 and ±1.00 D.Results: The Ocular MD SRK/T and Ocular MD Haigis averages produced mean arithmetic IOL prediction errors of 0.57 and –0.61 diopters (D, respectively, which were significantly larger than errors from the ASCRS, Ocular MD, and all calculator averages (0.11, –0.02, and 0.02 D, respectively, all P < 0.05. There was no statistically significant difference between the methods in absolute IOL prediction error, variance, or the percentage of eyes with outcomes within ±0.50 and ±1.00 D.Conclusion: The ASCRS average was more accurate in predicting IOL power than the Ocular MD SRK/T and Ocular MD Haigis averages alone. Our methods using combinations of these averages which, when compared with the individual averages, showed a trend of decreased mean arithmetic IOL

Defining Moments in MMWR History: The AIDS Epidemic, Pneumocystis Pneumonia --- Los Angeles 1981

Centers for Disease Control (CDC) Podcasts

On June 5, 1981, MMWR published a report of Pneumocystis pneumonia in five previously healthy young gay men in Los Angeles, California. This report was later acknowledged as the first published account of what would become known as human immunodeficiency virus, or HIV, and acquired immunodeficiency syndrome, or AIDS. It was the first of many MMWR reports that led to a better understanding of this new condition. In this podcast, Dr. Harold Jaffe recalls CDC's investigation and response to the AIDS Epidemic.

Glucose Sensor MdHXK1 Phosphorylates and Stabilizes MdbHLH3 to Promote Anthocyanin Biosynthesis in Apple

Science.gov (United States)

Hu, Da-Gang; Zhang, Quan-Yan; An, Jian-Ping; You, Chun-Xiang; Hao, Yu-Jin

2016-01-01

Glucose induces anthocyanin accumulation in many plant species; however, the molecular mechanism involved in this process remains largely unknown. Here, we found that apple hexokinase MdHXK1, a glucose sensor, was involved in sensing exogenous glucose and regulating anthocyanin biosynthesis. In vitro and in vivo assays suggested that MdHXK1 interacted directly with and phosphorylated an anthocyanin-associated bHLH transcription factor (TF) MdbHLH3 at its Ser361 site in response to glucose. Furthermore, both the hexokinase_2 domain and signal peptide are crucial for the MdHXK1-mediated phosphorylation of MdbHLH3. Moreover, phosphorylation modification stabilized MdbHLH3 protein and enhanced its transcription of the anthocyanin biosynthesis genes, thereby increasing anthocyanin biosynthesis. Finally, a series of transgenic analyses in apple calli and fruits demonstrated that MdHXK1 controlled glucose-induced anthocyanin accumulation at least partially, if not completely, via regulating MdbHLH3. Overall, our findings provide new insights into the mechanism of the glucose sensor HXK1 modulation of anthocyanin accumulation, which occur by directly regulating the anthocyanin-related bHLH TFs in response to a glucose signal in plants. PMID:27560976

Glucose Sensor MdHXK1 Phosphorylates and Stabilizes MdbHLH3 to Promote Anthocyanin Biosynthesis in Apple.

Directory of Open Access Journals (Sweden)

Da-Gang Hu

2016-08-01

Full Text Available Glucose induces anthocyanin accumulation in many plant species; however, the molecular mechanism involved in this process remains largely unknown. Here, we found that apple hexokinase MdHXK1, a glucose sensor, was involved in sensing exogenous glucose and regulating anthocyanin biosynthesis. In vitro and in vivo assays suggested that MdHXK1 interacted directly with and phosphorylated an anthocyanin-associated bHLH transcription factor (TF MdbHLH3 at its Ser361 site in response to glucose. Furthermore, both the hexokinase_2 domain and signal peptide are crucial for the MdHXK1-mediated phosphorylation of MdbHLH3. Moreover, phosphorylation modification stabilized MdbHLH3 protein and enhanced its transcription of the anthocyanin biosynthesis genes, thereby increasing anthocyanin biosynthesis. Finally, a series of transgenic analyses in apple calli and fruits demonstrated that MdHXK1 controlled glucose-induced anthocyanin accumulation at least partially, if not completely, via regulating MdbHLH3. Overall, our findings provide new insights into the mechanism of the glucose sensor HXK1 modulation of anthocyanin accumulation, which occur by directly regulating the anthocyanin-related bHLH TFs in response to a glucose signal in plants.

Water quality improvement policies: lessons learned from the implementation of Proposition O in Los Angeles, California

Science.gov (United States)

Mi-Hyun Park; Michael Stenstrom; Stephanie Pincetl

2009-01-01

This article evaluates the implementation of Proposition O, a stormwater cleanup measure, in Los Angeles, California. The measure was intended to create new funding to help the city comply with the Total Maximum Daily Load requirements under the federal Clean Water Act. Funding water quality objectives through a bond measure was necessary because the city had...

Sibling deidentification in the clinic: devil vs. angel.

Science.gov (United States)

Schachter, F F

1985-09-01

A four-member family structure consisting of two siblings contrasting in personality (sibling deidentification) and each identified with a different parent (split-parent identification) was recently reported (15). In well-functioning families, this tetrad or quadrangle is wide-spread in the first pair of siblings in the family and tends to be more common in same-sex pairs, suggesting that sibling deidentification is designed to mitigate the relatively intense sibling rivalry characteristic of these pairs and hence to maintain family harmony. In this collated case report, deidentification is found to follow the same pattern in 39 clinic first pairs. However, contrasting attributes are varied and nonevaluative in nonclinic pairs but mainly "good-bad" in clinic pairs, with polarization extreme. Results suggest that nonclinic siblings negotiate their identity (being) much as they negotiate about possessions (having) and that negotiations are blocked in clinic pairs, freezing mythic devil or angel identity. Intervention is directed at dislodging this block.

HIV transmission in the adult film industry--Los Angeles, California, 2004.

Science.gov (United States)

2005-09-23

In April 2004, the Los Angeles County Department of Health Services (LACDHS) received reports of work-related exposure to human immunodeficiency virus (HIV) in the heterosexual segment of the adult film industry in California. This report summarizes an investigation by LACDHS into four work-related HIV-transmission cases among adult film industry workers. The investigation was initiated April 20, 2004, and joined by the California Department of Industrial Relations, Division of Occupational Safety and Health (Cal/OSHA) on April 21, 2004, and by CDC on May 18, 2004. This investigation identified important and remediable gaps in the prevention of HIV and other sexually transmitted diseases (STDs) in the adult film industry.

Novel 3D/VR interactive environment for MD simulations, visualization and analysis.

Science.gov (United States)

Doblack, Benjamin N; Allis, Tim; Dávila, Lilian P

2014-12-18

The increasing development of computing (hardware and software) in the last decades has impacted scientific research in many fields including materials science, biology, chemistry and physics among many others. A new computational system for the accurate and fast simulation and 3D/VR visualization of nanostructures is presented here, using the open-source molecular dynamics (MD) computer program LAMMPS. This alternative computational method uses modern graphics processors, NVIDIA CUDA technology and specialized scientific codes to overcome processing speed barriers common to traditional computing methods. In conjunction with a virtual reality system used to model materials, this enhancement allows the addition of accelerated MD simulation capability. The motivation is to provide a novel research environment which simultaneously allows visualization, simulation, modeling and analysis. The research goal is to investigate the structure and properties of inorganic nanostructures (e.g., silica glass nanosprings) under different conditions using this innovative computational system. The work presented outlines a description of the 3D/VR Visualization System and basic components, an overview of important considerations such as the physical environment, details on the setup and use of the novel system, a general procedure for the accelerated MD enhancement, technical information, and relevant remarks. The impact of this work is the creation of a unique computational system combining nanoscale materials simulation, visualization and interactivity in a virtual environment, which is both a research and teaching instrument at UC Merced.

75 FR 49956 - Dewey C. Mackay, M.D.; Revocation of Registration

Science.gov (United States)

2010-08-16

... DEPARTMENT OF JUSTICE Drug Enforcement Administration [Docket No. 09-28] Dewey C. Mackay, M.D.; Revocation of Registration On February 26, 2009, I, the Deputy Administrator of the Drug Enforcement Administration (DEA), issued an Order to Show Cause and Immediate Suspension of Registration to Dewey C. MacKay...

Microsecond MD Simulations of Nano-patterned Polymer Brushes on Self-Assembled Monolayers

Science.gov (United States)

Buie, Creighton; Qiu, Liming; Cheng, Kwan; Park, Soyeun

2010-03-01

Nano-patterned polymer brushes end-grafted onto self-assembled monolayers have gained increasing research interests due to their unique thermodynamic properties and their chemical and biomedical applications in colloids, biosensing and tissue engineering. So far, the interactions between the polymer brushes with the surrounding environments such as the floor and solvent at the nanometer length scale and microsecond time scale are still difficult to obtained experimentally and computationally. Using a Coarse-Grained MD approach, polymer brushes of different monomeric lengths, grafting density and hydrophobicity of the monomers grafted on self-assembled monolayers and in explicit solvent were studied. Molecular level information, such as lateral diffusion, transverse height and volume contour of the brushes, were calculated from our microsecond-MD simulations. Our results demonstrated the significance of the hydration of the polymer in controlling the conformational arrangement of the polymer brushes.

Assessing the distribution of environmental stewardship organizations and their relationship to the demographics of Los Angeles County

Science.gov (United States)

Krystle M. Golly

2017-01-01

An equal distribution of environmental stewardship organizations across the urban landscape provides an environment that facilitates community empowerment. The systemic issues found in Los Angeles County play an important role in the social development of the area. Through the utilization of modern technology and geographical mapping software, spatial distribution of...

Mga Lente sa Likod ng Lente: Isang Panimulang Pag-aaral ng Ilang Litratong Kuha ni Xander Angeles

Directory of Open Access Journals (Sweden)

Moreal Nagarit Camba

2011-12-01

Full Text Available Ang pangalang Xander Angeles ay kilala bilang isa sa mga in-demand napangalan sa mundo ng fashion at advertisement sa Pilipinas. Kakabit ngpangalang ito ang samut-saring lokal at internasyunal na parangal; idagdag pa rito ang isang advertising company, isang modelling agency, at isang fashion and photography school.

MD1271: Effect of low frequency noise on the evolution of the emittance and halo population

CERN Document Server

Fitterer, Miriam; Valishev, Alexander; Bruce, Roderik; Hofle, Wolfgang; Hostettler, Michi; Papadopoulou, Parthena Stefania; Papotti, Giulia; Papaphilippou, Yannis; Pellegrini, Dario; Trad, Georges; Valuch, Daniel; Valentino, Gianluca; Wagner, Joschka; Cai, Xu; CERN. Geneva. ATS Department

2018-01-01

For the High Luminosity upgrade the β* in IR1 and IR5 will be further reduced compared to the current LHC. As the β* decreases the β-functions in the inner triplet (IT) increase resulting in a higher sensitivity of the HL-LHC to ground motion in the IT region or to increases of the low frequency noise. Noise can in general lead to emittance growth and higher halo population and diffusion rate. However, it is usually assumed in the literature that only frequencies close to the betatron frequencies and sidebands have an effect on the emittance and tail population. To test this theory, an MD was carried out to observe if also low frequency noise can lead to emittance growth and stronger halo population and diffusion. This MD conducted on 24.08.2016 follows a previous MD on 05.11.2015/06.11.2015

77 FR 68149 - Karen Paul Holley, M.D.; Decision and Order

Science.gov (United States)

2012-11-15

... DEPARTMENT OF JUSTICE Drug Enforcement Administration [Docket No. 12-51] Karen Paul Holley, M.D... revoke the DEA Certificate of Registration (COR), Number BH8988339, of Karen Paul Holley, M.D....D., 74 FR 17528, 174529 (2009); John B. Freitas, D.O., 74 FR 17524, 17525 (2009); Roger A. Rodriguez...

Failure to launch: the self-regulating Md-MYB10 R6 gene from apple is active in flowers but not leaves of Petunia.

Science.gov (United States)

Boase, Murray R; Brendolise, Cyril; Wang, Lei; Ngo, Hahn; Espley, Richard V; Hellens, Roger P; Schwinn, Kathy E; Davies, Kevin M; Albert, Nick W

2015-10-01

The Md - MYB10 R6 gene from apple is capable of self-regulating in heterologous host species and enhancing anthocyanin pigmentation, but the activity of MYB10 is dependent on endogenous protein partners. Coloured foliage due to anthocyanin pigments (bronze/red/black) is an attractive trait that is often lacking in many bedding, ornamental and horticultural plants. Apples (Malus × domestica) containing an allelic variant of the anthocyanin regulator, Md-MYB10 R6 , are highly pigmented throughout the plant, due to autoregulation by MYB10 upon its own promoter. We investigated whether Md-MYB10 R6 from apple is capable of functioning within the heterologous host Petunia hybrida to generate plants with novel pigmentation patterns. The Md-MYB10 R6 transgene (MYB10-R6 pro :MYB10:MYB10 term ) activated anthocyanin synthesis when transiently expressed in Antirrhinum rosea (dorsea) petals and petunia leaf discs. Stable transgenic petunias containing Md-MYB10 R6 lacked foliar pigmentation but had coloured flowers, complementing the an2 phenotype of 'Mitchell' petunia. The absence of foliar pigmentation was due to the failure of the Md-MYB10 R6 gene to self-activate in vegetative tissues, suggesting that additional protein partners are required for Md-MYB10 to activate target genes in this heterologous system. In petunia flowers, where endogenous components including MYB-bHLH-WDR (MBW) proteins were present, expression of the Md-MYB10 R6 promoter was initiated, allowing auto-regulation to occur and activating anthocyanin production. Md-MYB10 is capable of operating within the petunia MBW gene regulation network that controls the expression of the anthocyanin biosynthesis genes, AN1 (bHLH) and MYBx (R3-MYB repressor) in petals.

Body Image of Dancers in Los Angeles: The Cult of Slenderness and Media Influence among Dance Students

Science.gov (United States)

Heiland, Teresa L.; Murray, Darrin S.; Edley, Paige P.

2008-01-01

Body image and self-esteem are examined through personal stories among Los Angeles college dancers who grew up in the Hollywood culture of the cult of slenderness. The study incorporates a body image survey, eating disorder screen, and an interview process capturing dancers' lived experiences with daily pressures. Dancers reveal their experiences…

Trees grow on money: Urban tree canopy cover and environmental justice

Science.gov (United States)

Kirsten Schwarz; Michail Fragkias; Christopher G. Boone; Weiqi Zhou; Melissa McHale; J. Morgan Grove; Jarlath O' Neil-Dunne; Joseph P. McFadden; Geoffrey L. Buckley; Dan Childers; Laura Ogden; Stephanie Pincetl; Diane Pataki; Ali Whitmer; Mary L. Cadenasso; Steven Arthur. Loiselle

2015-01-01

This study examines the distributional equity of urban tree canopy (UTC) cover for Baltimore, MD, Los Angeles, CA, New York, NY, Philadelphia, PA, Raleigh, NC, Sacramento, CA, and Washington, D.C. using high spatial resolution land cover data and census data. Data are analyzed at the Census Block Group levels using Spearman’s correlation, ordinary least squares...

Public Opinion on Nutrition-Related Policies to Combat Child Obesity, Los Angeles County, 2011

OpenAIRE

Simon, Paul A.; Chiang, Choiyuk; Lightstone, Amy S.; Shih, Margaret

2014-01-01

We assessed public opinion on nutrition-related policies to address child obesity: a soda tax, restrictions on advertising unhealthy foods and beverages to children, and restrictions on siting fast food restaurants and convenience stores near schools. We analyzed data from 998 adults (aged ≥18 years) in the 2011 Los Angeles County Health Survey. Support was highest for advertising restrictions (74%), intermediate for a soda tax (60%), and lowest for siting restrictions on fast food restaurant...

Vista-LA: Mapping methane-emitting infrastructure in the Los Angeles megacity

Science.gov (United States)

Carranza, Valerie; Rafiq, Talha; Frausto-Vicencio, Isis; Hopkins, Francesca M.; Verhulst, Kristal R.; Rao, Preeti; Duren, Riley M.; Miller, Charles E.

2018-03-01

Methane (CH4) is a potent greenhouse gas (GHG) and a critical target of climate mitigation efforts. However, actionable emission reduction efforts are complicated by large uncertainties in the methane budget on relevant scales. Here, we present Vista, a Geographic Information System (GIS)-based approach to map potential methane emissions sources in the South Coast Air Basin (SoCAB) that encompasses Los Angeles, an area with a dense, complex mixture of methane sources. The goal of this work is to provide a database that, together with atmospheric observations, improves methane emissions estimates in urban areas with complex infrastructure. We aggregated methane source location information into three sectors (energy, agriculture, and waste) following the frameworks used by the State of California GHG Inventory and the Intergovernmental Panel on Climate Change (IPCC) Guidelines for GHG Reporting. Geospatial modeling was applied to publicly available datasets to precisely geolocate facilities and infrastructure comprising major anthropogenic methane source sectors. The final database, Vista-Los Angeles (Vista-LA), is presented as maps of infrastructure known or expected to emit CH4. Vista-LA contains over 33 000 features concentrated on Vista-LA is used as a planning and analysis tool for atmospheric measurement surveys of methane sources, particularly for airborne remote sensing, and methane hotspot detection using regional observations. This study represents a first step towards developing an accurate, spatially resolved methane flux estimate for point sources in SoCAB, with the potential to address discrepancies between bottom-up and top-down methane emissions accounting in this region. The Vista-LA datasets and associated metadata are available from the Oak Ridge National Laboratory Distributed Active Archive Center for Biogeochemical Dynamics (ORNL DAAC; https://doi.org/10.3334/ORNLDAAC/1525).

Harold E. Varmus, MD.

Science.gov (United States)

Varmus, H E

1995-06-01

On November 19, 1993, the Senate approved the nomination of Harold E. Varmus, MD, as Director of the National Institutes of Health (NIH). Varmus, who received the 1989 Nobel Prize in Medicine, brought unquestioned credentials as a scientist to the NIH. Despite his limited background as an administrator, Varmus has received high marks from most observers for improving the morale of NIH staffers and implementing streamlined procedures in the grant review process. His tenure has not been free of controversy, however. Many clinical researchers have long felt there is a bias in NIH study sections against patient-oriented research. A recent study sponsored by the Division of Research Grants confirmed the lower success rate of patient-oriented research proposals, but the outcome of these findings remains unclear. Faced with mounting political pressure for a balanced budget, and the resultant reduction of funding to many branches of government, Varmus has been a strong voice for non-targeted investigator initiated research. Interviewed in his office in Building One on the NIH campus in Bethesda, Maryland, Varmus discussed the state of patient oriented research, the evolving role of the NIH in supporting science, and just where the money to pay for it should be found.

Identifying Characters of “Where Angel Fear to Tread Novel” in Teaching Literary Work

Directory of Open Access Journals (Sweden)

Suhaimi Suhaimi

2016-07-01

Full Text Available The aim of the research is to identify some characters in the novel Where Angels Fear to Tread in teaching literary works. In learning of characters, someone will understand about the term of the interests, desires, emotions, and moral those form the individual within a story. Library research was used in thid study. The experts divide characters become two characters; they are central characters and additional characters. Central characters are a character who takes the greatest part in the main character or a figure that is most telling. Volume appearance of the main character more than the other characters. Meanwhile, additional characters or subordinate figures are figures that appear once or several times, figures that support or assist the central figure. In the novel Where Angels Fear To Tread, writer found some figures or characters such as: Mrs. Herriton, Lilia, Philip, Gino, and Carroline Abbot. Each of them had different characters; Mrs Herriton was a selfish and arrogant because she came from a high social status. Lilia was a patient and never denied what was ruled by her mother in-low although sometimes she was often treated her like slaves. Philip was figured as a handsome man, his tolerance and empathy were high. Gino was figured as stupid character. Miss Abbott as a nice, quiet, dull, and friendly.

An historical experiment: Los Angeles smog evolution observed by blimp.

Science.gov (United States)

Hidy, G M

2018-02-12

Observations of smog over the Los Angeles Basin (LAB) links high oxidant mixing ratios with poor visibility, sometimes smog by blimp in a Lagrangian-like format. The experiment on September 6, 1973, demonstrated that a blimp could travel with the wind across the LAB, observing ozone (O 3 ) and precursors, and particles of different size ranges. These included condensation nuclei (CN) concentrations dominated by particles of ≤ 0.1 µm diameter and light scattering coefficient (b sc ) representing mainly particles of 0.1-2.0 µm diameter. The results indicated a pollutant variation similar to that measured at a fixed site. Ozone was produced in an air mass, reaching a maximum of ~400 ppb in the presence of nitrogen oxides (NO x ) and nonmethane hydrocarbons (NMHCs), then declined. Although the photochemistry was developing, b sc grew with O 3 mixing ratio to a quasi-steady state at ~9-10 × 10 -4  m -1 , decreasing in value much later with decease in O 3 . The light scattering coefficient was found to be positively associated with the O 3 mixing ratio, whereas CN concentrations were negatively proportional to O 3 mixing ratio. The blimp experiment was supported with aircraft vertical profiles and ground-level observations from a mobile laboratory. The blimp flight obtained combined gas and particle changes aloft that could not be obtained by ground or fixed-wing aircraft measurements alone. The experiment was partially successful in achieving a true Lagrangian characterization of smog chemistry in a constrained or defined "open" air mass. The Los Angeles experiment demonstrated the use of a blimp as a platform for measurement of air pollution traveling with an air mass across an urban area. The method added unique data showing the relationship between photochemical smog chemistry and aerosol dynamics in smog. The method offers an alternative to reliance on smog chamber and modeling observations to designing air quality management strategies for reactive

Infrared microspectroscopy of live cells in microfluidic devices (MD-IRMS): toward a powerful label-free cell-based assay.

Science.gov (United States)

Vaccari, L; Birarda, G; Businaro, L; Pacor, S; Grenci, G

2012-06-05

Until nowadays most infrared microspectroscopy (IRMS) experiments on biological specimens (i.e., tissues or cells) have been routinely carried out on fixed or dried samples in order to circumvent water absorption problems. In this paper, we demonstrate the possibility to widen the range of in-vitro IRMS experiments to vibrational analysis of live cellular samples, thanks to the development of novel biocompatible IR-visible transparent microfluidic devices (MD). In order to highlight the biological relevance of IRMS in MD (MD-IRMS), we performed a systematic exploration of the biochemical alterations induced by different fixation protocols, ethanol 70% and formaldehyde solution 4%, as well as air-drying on U937 leukemic monocytes by comparing their IR vibrational features with the live U937 counterpart. Both fixation and air-drying procedures affected lipid composition and order as well as protein structure at a different extent while they both induced structural alterations in nucleic acids. Therefore, only IRMS of live cells can provide reliable information on both DNA and RNA structure and on their cellular dynamic. In summary, we show that MD-IRMS of live cells is feasible, reliable, and biologically relevant to be recognized as a label-free cell-based assay.

Designing and conducting MD/MPH dual degree program in the Medical School of Shiraz University of Medical Sciences.

Science.gov (United States)

Salehi, Alireza; Hashemi, Neda; Saber, Mahboobeh; Imanieh, Mohammad Hadi

2015-07-01

Many studies have focused on the need of health systems to educated physicians in the clinical prevention, research methodology, epidemiology and health care management and emphasize the important role of this training in the public health promotion. On this basis, Shiraz University of Medical Sciences (SUMS) has established MD/MPH dual degree program since the year 2012. In the current study, Delphi technique was used. Both qualitative and quantitative methods were applied in the Delphi process. The Delphi team members including experts with extensive experience in teaching, research and administration in the field of educational management and health/medical education reached consensus in almost 86% of the questionnaire items through three Delphi rounds. MD/MPH program for SUMS was designed based on the items agreed and thematic analysis used in these rounds. The goals, values, mission and program requirements including the period, the entrance condition, and the number of units, and certification were determined. Accordingly, the courses of the program are presented in parallel with the MD education period. MPH courses consist of 35 units including 16 obligatory and 15 voluntary ones. Designing MD/MPH program in SUMS based on the existent models in the universities in different countries, compatible with educational program of this university and needs of national health system in Iran, can be a beneficial measure towards promoting the students' knowledge and theoretical/practical skills in both individual and social level. Performing some additional research to assess the MD/MPH program and some cohort studies to evaluate the effect of this program on the students' future professional life is recommended.

Property values, parks, and crime: a hedonic analysis in Baltimore, MD

Science.gov (United States)

Austin Troy; J. Morgan Grove

2008-01-01

While urban parks are generally considered to be a positive amenity, past research suggests that some parks are perceived as a neighborhood liability. Using hedonic analysis of property data in Baltimore, MD, we attempted to determine whether crime rate mediates how parks are valued by the housing market. Transacted price was regressed against park proximity, area-...

Making Cultura Count inside and out of the Classroom: Public Art & Critical Pedagogy in South Central Los Angeles

Science.gov (United States)

Garcia, Luis-Genaro

2012-01-01

In this article, artist, educator, and activist Luis-Genaro Garcia describes the development and impact of the "May Day service learning project" on his advanced painting class in a high school in South Los Angeles. The project emerged from students' interests: their ideas, concerns for their community, socio-political consciousness, and…

77 FR 35054 - Donald Brooks Reece II, M.D.; Dismissal of Proceeding

Science.gov (United States)

2012-06-12

..., M.D. (Respondent), of Morehead City, N.C. The Order proposed the revocation of Respondent's DEA... pleading entitled: ``Notice To The Administrator Regarding State Authority,'' with attachments. Therein..., at 3. This Order was effective on December 8, 2011. Id., Attachment 5, at 6. Upon review of the...

75 FR 53574 - Safety Zone; Fireworks Displays, Potomac River, National Harbor, MD

Science.gov (United States)

2010-09-01

...-AA00 Safety Zone; Fireworks Displays, Potomac River, National Harbor, MD AGENCY: Coast Guard, DHS... safety of life on navigable waters during five fireworks displays launched from a discharge barge located... necessary to protect persons and vessels against the hazards associated with a fireworks display on...

Expression Analysis of the MdCIbHLH1 Gene in Apple Flower Buds and Seeds in the Process of Dormancy

Directory of Open Access Journals (Sweden)

Yiran Ren

2016-03-01

Full Text Available A bHLH transcription factor that is induced by low temperature was found in apple (Malus × domestica Borkh.. To understand the sequence characteristics of the gene, bioinformatics analysis was performed. Furthermore, gene expression patterns of the laminated apple seeds and lateral flower buds were analyzed during the period of dormancy release with semi-quantitative RT-PCR. Based on secondary structure predictions, the results showed that the MdCIbHLH1 protein structure mainly included α-helix and random coil, while β-sheet and extended strand content was less. Semi-quantitative RT-PCR analysis showed that the expression patterns of MdCIbHLH1 were similar in laminated apple seeds and lateral flower buds during the period of dormancy release. Before dormancy release, expression levels of MdCIbHLH1 were high and gradually decreased during the period of dormancy release. These results indicated that MdCIbHLH1 might play an important role during dormancy release in apple seeds and apple buds.

Proteomics and SSH analyses of ALA-promoted fruit coloration and evidence for the involvement of a MADS-box gene, MdMADS1

Directory of Open Access Journals (Sweden)

Xinxin Feng

2016-11-01

Full Text Available Skin color is a key quality attribute of fruits and how to improve fruit coloration has long been a major concern. 5-Aminolevulinic acid (ALA, a natural plant growth regulator, can significantly increase anthocyanin accumulation in fruit skin and therefore effectively improve coloration of many fruits, including apple. However, the molecular mechanism how ALA stimulates anthocyanin accumulation in fruit skin remains unknown. Here, we investigated the impact of ALA on apple skin at the protein and mRNA levels. A total of 85 differentially expressed proteins in apple skins between ALA and water treatment (control were identified by complementary gel-based and gel-freeseparation techniques. Most of these differentially expressed proteins were up-regulated by ALA. Function analysis suggested that 87.06% of the ALA-responsive proteins were associated with fruit ripening. To further screen ALA-responsive regulators, we constructed a subtracted cDNA library (tester: ALA treatment; driver: control and obtained 104 differentially expressed unigenes, of which 38 unigenes were indicators for the fruit ripening-related gene. The differentially changed proteins and transcripts did not correspond well at an individual level, but showed similar regulated direction in function at the pathway level. Among the identified fruit ripening-related genes, the expression of MdMADS1, a developmental transcription regulator of fruit ripening, was positively correlated with expression of anthocyanin biosynthetic genes (MdCHS, MdDFR, MdLDOX and MdUFGT in apple skin under ALA treatment. Moreover, overexpression of MdMADS1 enhanced anthocyanin content in transformed apple calli, which was further enhanced by ALA. The anthocyanin content in MdMADS1-silenced calli was less than that in the control with ALA treatment, but higher than that without ALA treatment. These results indicated that MdMADS1 is involved in ALA-induced anthocyanin accumulation. In addition, anthocyanin

The first nationwide survey of MD-PhDs in the social sciences and humanities: training patterns and career choices.

Science.gov (United States)

Holmes, Seth M; Karlin, Jennifer; Stonington, Scott D; Gottheil, Diane L

2017-03-21

While several articles on MD-PhD trainees in the basic sciences have been published in the past several years, very little research exists on physician-investigators in the social sciences and humanities. However, the numbers of MD-PhDs training in these fields and the number of programs offering training in these fields are increasing, particularly within the US. In addition, accountability for the public funding for MD-PhD programs requires knowledge about this growing population of trainees and their career trajectories. The aim of this paper is to describe the first cohorts of MD-PhDs in the social sciences and humanities, to characterize their training and career paths, and to better understand their experiences of training and subsequent research and practice. This paper utilizes a multi-pronged recruitment method and novel survey instrument to examine an understudied population of MD-PhD trainees in the social sciences and humanities, many of whom completed both degrees without formal programmatic support. The survey instrument was designed to collect demographic, training and career trajectory data, as well as experiences of and perspectives on training and career. It describes their routes to professional development, characterizes obstacles to and predictors of success, and explores career trends. The average length of time to complete both degrees was 9 years. The vast majority (90%) completed a clinical residency, almost all (98%) were engaged in research, the vast majority (88%) were employed in academic institutions, and several others (9%) held leadership positions in national and international health organizations. Very few (4%) went into private practice. The survey responses supply recommendations for supporting current trainees as well as areas for future research. In general, MD-PhDs in the social sciences and humanities have careers that fit the goals of agencies providing public funding for training physician-investigators: they are involved

Prevalence of mood disorders and utility of the PRIME-MD in patients undergoing radiation therapy

International Nuclear Information System (INIS)

Leopold, Kenneth A.; Ahles, Tim A.; Walch, Susan; Amdur, Robert J.; Mott, Leila A.; Wiegand-Packard, Linda; Oxman, Thomas E.

1998-01-01

Purpose: To validate a short, structured interview procedure that allows practicing oncologists to quickly and reliably identify mood disorders in their patients, and to estimate the prevalence and types of mood disorders in a radiation therapy patient setting, noting relationships between mood disorders and patient characteristics. Methods: Consecutive, eligible adult patients from the practices of two radiation oncologists were administered the Primary Care Evaluation of Mental Disorders (PRIME-MD) by the treating physician. A subset of these patients was also evaluated with the SCID, administered by trained mental health care personnel. Agreement between the two instruments was examined using the kappa statistic. Prevalence of mood disorders was determined from the PRIME-MD. The significance of relationships between patient characteristics and mood disorders was examined by chi-square and ANOVA analysis, and subsequently by multivariate logistic regression analysis. Results: One hundred twenty-two patients were studied. Fifty-three of these were administered the SCID. Agreement between the two instruments was very good (kappa = 0.70). A diagnosis of a depressive or anxiety disorder by the PRIME-MD was made in 59 of the 122 patients (48%, 95% confidence interval = 39%, 58%). Multivariate analysis showed that a diagnosis of a depressive mood disorder was significantly related to pain intensity and prior history of depression. Conclusion: We have demonstrated the validity and feasibility of the PRIME-MD administered by oncologists in making diagnoses of mood disorders. The prevalence of mood disorders in our set of patients undergoing a course of RT was nearly 50%. Future studies should describe the natural history of these disorders, and determine optimal intervention strategies

Figurino, moda e luxo no filme Zuzu Angel

Directory of Open Access Journals (Sweden)

Haussen, Luciana Fagundes

2012-01-01

Full Text Available O artigo analisa o figurino de cinema a partir do filme Zuzu Angel (Sergio Rezende, 2006, e discute como é representada a obra desta designer brasileira de roupas das décadas de 60 e 70, sob o aspecto da relação de seu trabalho com as idéias de moda e luxo. Destaca a trajetória da equipe de produção do figurino do filme e a repercussão das suas escolhas em cenas-chave desta produção audiovisual. Para tanto, trabalha com a contextualização histórica, a narrativa cinematográfica e com os conceitos de figurino de cinema, moda e luxo. Como suporte teórico, recorre às obras de, Michel Pastoureau, para as análises dos tecidos, de Jean-Jacques Roubine, Deborah Nadoolman Landis e Marcel Martin, sobre o papel do figurino na dramaturgia e no cinema, e Gilles Lipovetsky sobre os conceitos de moda e luxo

Fragmented Flows: Water Supply in Los Angeles County

Science.gov (United States)

Pincetl, Stephanie; Porse, Erik; Cheng, Deborah

2016-08-01

In the Los Angeles metropolitan region, nearly 100 public and private entities are formally involved in the management and distribution of potable water—a legacy rooted in fragmented urban growth in the area and late 19th century convictions about local control of services. Yet, while policy debates focus on new forms of infrastructure, restructured pricing mechanisms, and other technical fixes, the complex institutional architecture of the present system has received little attention. In this paper, we trace the development of this system, describe its interconnections and disjunctures, and demonstrate the invisibility of water infrastructure in LA in multiple ways—through mapping, statistical analysis, and historical texts. Perverse blessings of past water abundance led to a complex, but less than resilient, system with users accustomed to cheap, easily accessible water. We describe the lack of transparency and accountability in the current system, as well as its shortcomings in building needed new infrastructure and instituting new water rate structures. Adapting to increasing water scarcity and likely droughts must include addressing the architecture of water management.

Urban Income Inequality and the Great Recession in Sunbelt Form: Disentangling Individual and Neighborhood-Level Change in Los Angeles

Directory of Open Access Journals (Sweden)

Robert J. Sampson

2017-02-01

Full Text Available New social transformations within and beyond the cities of classic urban studies challenge prevailing accounts of spatial inequality. This paper pivots from the Rust Belt to the Sunbelt accordingly, disentangling persistence and change in neighborhood median income and concentrated income extremes in Los Angeles County. We first examine patterns of change over two decades starting in 1990 for all Los Angeles neighborhoods. We then analyze an original longitudinal study of approximately six hundred Angelenos from 2000 to 2013, assessing the degree to which contextual changes in neighborhood income arise from neighborhood-level mobility or individual residential mobility. Overall we find deep and persistent inequality among both neighborhoods and individuals. Contrary to prior research, we also find that residential mobility does not materially alter neighborhood economic conditions for most race, ethnic, and income groups. Our analyses lay the groundwork for a multilevel theoretical framework capable of explaining spatial inequality across cities and historical eras.

Large Oncosomes: A Novel Liquid Biopsy for Genetic Profiling in Patients with Castration-Resistant Prostate Cancer

Science.gov (United States)

2017-09-01

Resistant Prostate Cancer PRINCIPAL INVESTIGATOR: Dolores Di Vizio, MD, PhD CONTRACTING ORGANIZATION: Cedars-Sinai Medical Center Los Angeles...Castration-Resistant Prostate Cancer 5a. CONTRACT NUMBER 5b. GRANT NUMBER W81XWH-16-1-0397 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Dolores Di...biopsy” changing the landscape of precision medicine. 15. SUBJECT TERMS Metastatic Castration Resistant Prostate Cancer , Extracellular Vesicles

Potentially induced earthquakes during the early twentieth century in the Los Angeles Basin

Science.gov (United States)

Hough, Susan E.; Page, Morgan T.

2016-01-01

Recent studies have presented evidence that early to mid‐twentieth‐century earthquakes in Oklahoma and Texas were likely induced by fossil fuel production and/or injection of wastewater (Hough and Page, 2015; Frohlich et al., 2016). Considering seismicity from 1935 onward, Hauksson et al. (2015) concluded that there is no evidence for significant induced activity in the greater Los Angeles region between 1935 and the present. To explore a possible association between earthquakes prior to 1935 and oil and gas production, we first revisit the historical catalog and then review contemporary oil industry activities. Although early industry activities did not induce large numbers of earthquakes, we present evidence for an association between the initial oil boom in the greater Los Angeles area and earthquakes between 1915 and 1932, including the damaging 22 June 1920 Inglewood and 8 July 1929 Whittier earthquakes. We further consider whether the 1933 Mw 6.4 Long Beach earthquake might have been induced, and show some evidence that points to a causative relationship between the earthquake and activities in the Huntington Beach oil field. The hypothesis that the Long Beach earthquake was either induced or triggered by an foreshock cannot be ruled out. Our results suggest that significant earthquakes in southern California during the early twentieth century might have been associated with industry practices that are no longer employed (i.e., production without water reinjection), and do not necessarily imply a high likelihood of induced earthquakes at the present time.

Estimation of Methane Emissions in the Los Angeles Basin using CLARS-FTS Observations

Science.gov (United States)

Sander, S.; Zeng, Z. C.; Pongetti, T.; Duren, R. M.; Shia, R. L.; Yung, Y. L.; He, L.; Gurney, K. R.

2017-12-01

The Los Angeles Basin (LA Basin), covering almost 10,743 square miles, is home to over 16.8 million people - about half the population of the state of California. It is also the second most populated urban area in the United States and one of the major source of anthropogenic greenhouse gases. Using FTIR observations from the California Laboratory for Atmospheric Remote Sensing (CLARS) located on Mount Wilson at an altitude of 1673m, we measure the reflected near infrared sunlight from 33 surface targets in the Los Angeles megacity including the direct solar beam which gives the free tropospheric background. We then retrieve the excess slant column abundances of important trace gases such as carbon dioxide (CO2) and methane (CH4) in the LA basin. Using atmospheric tracer - tracer correlations for CH4 and CO2 to eliminate the effect of aerosol scattering in the retrieval, we infer methane emissions based on the ratio of XCH4 excess to XCO2 excess. Significant variability is observed in the spatial distributions of excess CH4. Methane emissions in the LA basin show consistent peaks in late summer and winter during the period from Sep 2011 to the present. The strong correlation between natural gas usage data and derived CLARS methane emissions (r2 = 0.5) implies that natural gas leakage during transmission and/or consumption accounts for a significant fraction of the inferred seasonal variability of methane emissions in the LA basin. We will report updated annual trends in CH4 emissions from 2011 to the present. Copyright 2017. All rights reserved.

Heat Flow Data Cruise MD72 RV Marion Dufresne over the Mascarene Ridge

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Data were gathered by the R/V Marion Dufresne in May and June of 1992 over the Mascarene Ridge in the Indian Ocean on cruise MD72/MASCAFLUX. Heat flow measurements...

Should MD-PhD programs encourage graduate training in disciplines beyond conventional biomedical or clinical sciences?

Science.gov (United States)

O'Mara, Ryan J; Hsu, Stephen I; Wilson, Daniel R

2015-02-01

The goal of MD-PhD training programs is to produce physician-scientists with unique capacities to lead the future biomedical research workforce. The current dearth of physician-scientists with expertise outside conventional biomedical or clinical sciences raises the question of whether MD-PhD training programs should allow or even encourage scholars to pursue doctoral studies in disciplines that are deemed nontraditional, yet are intrinsically germane to major influences on health. This question is especially relevant because the central value and ultimate goal of the academic medicine community is to help attain the highest level of health and health equity for all people. Advances in medical science and practice, along with improvements in health care access and delivery, are steps toward health equity, but alone they will not come close to eliminating health inequalities. Addressing the complex health issues in our communities and society as a whole requires a biomedical research workforce with knowledge, practice, and research skills well beyond conventional biomedical or clinical sciences. To make real progress in advancing health equity, educational pathways must prepare physician-scientists to treat both micro and macro determinants of health. The authors argue that MD-PhD programs should allow and encourage their scholars to cross boundaries into less traditional disciplines such as epidemiology, statistics, anthropology, sociology, ethics, public policy, management, economics, education, social work, informatics, communications, and marketing. To fulfill current and coming health care needs, nontraditional MD-PhD students should be welcomed and supported as valuable members of our biomedical research workforce.

78 FR 68002 - Safety Zone for Fireworks Display, Baltimore Harbor, Baltimore, MD

Science.gov (United States)

2013-11-13

... 1625-AA00 Safety Zone for Fireworks Display, Baltimore Harbor, Baltimore, MD AGENCY: Coast Guard, DHS... safety of life on navigable waters during a fireworks display launched from a barge located in Baltimore... rule involves a fireworks display associated with a New Year's Eve event that will take place in...

76 FR 414 - Tier 1 Environmental Impact Statement for the Los Angeles to San Luis Obispo (LOSSAN North) Rail...

Science.gov (United States)

2011-01-04

... expected growth in population and resulting increases in intercity travel demand between Los Angeles and San Luis Obispo. As a result of this growth in travel demand, their travel delays from the growing... environmental analysis to help make corridor level decisions regarding the level of intercity passenger rail...

Defining Moments in MMWR History: The AIDS Epidemic, Pneumocystis Pneumonia --- Los Angeles 1981

Centers for Disease Control (CDC) Podcasts

2017-12-01

On June 5, 1981, MMWR published a report of Pneumocystis pneumonia in five previously healthy young gay men in Los Angeles, California. This report was later acknowledged as the first published account of what would become known as human immunodeficiency virus, or HIV, and acquired immunodeficiency syndrome, or AIDS. It was the first of many MMWR reports that led to a better understanding of this new condition. In this podcast, Dr. Harold Jaffe recalls CDC’s investigation and response to the AIDS Epidemic.  Created: 12/1/2017 by MMWR.   Date Released: 12/1/2017.

Epidemiologic study of neural tube defects in Los Angeles County. I. Prevalence at birth based on multiple sources of case ascertainment

Energy Technology Data Exchange (ETDEWEB)

Sever, L.E. (Pacific Northwest Lab., Richland, WA); Sanders, M.; Monsen, R.

1982-01-01

Epidemiologic studies of the neural tube defects (NTDs), anencephalus and spina bifida, have for the most part been based on single sources of case ascertainment in past studies. The present investigation attempts total ascertainment of NTD cases in the newborn population of Los Angeles County residents for the period 1966 to 1972. Design of the study, sources of data, and estimates of prevalence rates based on single and multiple sources of case ascertainment are here discussed. Anencephalus cases totaled 448, spina bifida 442, and encephalocele 72, giving prevalence rates of 0.52, 0.51, and 0.08 per 1000 total births, respectively, for these neural tube defects - rates considered to be low. The Los Angeles County prevalence rates are compared with those of other recent North American studies and support is provided for earlier suggestions of low rates on the West Coast.

MD-11 PCA - Research flight team egress

Science.gov (United States)

1995-01-01

This McDonnell Douglas MD-11 has parked on the flightline at NASA's Dryden Flight Research Center, Edwards, California, following its completion of the first and second landings ever performed by a transport aircraft under engine power only (on Aug. 29, 1995). The milestone flight, with NASA research pilot and former astronaut Gordon Fullerton at the controls, was part of a NASA project to develop a computer-assisted engine control system that enables a pilot to land a plane safely when its normal control surfaces are disabled. Coming down the steps from the aircraft are Gordon Fullerton (in front), followed by Bill Burcham, Propulsion Controlled Aircraft (PCA) project engineer at Dryden; NASA Dryden controls engineer John Burken; John Feather of McDonnell Douglas; and Drew Pappas, McDonnell Douglas' project manager for PCA.

β∗ levelling using the LHC Lumi Server (MD 2427)

CERN Document Server

Hostettler, Michi; Fuchsberger, Kajetan; Gabriel, Mathieu; Hemelsoet, Georges-Henry; Hruska, Marek; Jacquet, Delphine; Wenninger, Jorg; CERN. Geneva. ATS Department

2018-01-01

Luminosity levelling by β∗ is the baseline scenario for HL-LHC and will possibly be used in 2018 LHC operation. In this MD, we commissioned a novel controls approach to β∗ levelling using improved LSA trims and automatic orchestration. Compared to the regular squeeze using sequences, this approach is aimed to be minimally invasive to LHC operation in Stable Beams. Using this tool, we demonstrated the feasibility of β∗ levelling between 1 m and 30 cm.

MD 1691: Active halo control using tune ripple at injection

CERN Document Server

Garcia Morales, Hector; Bruce, Roderik; Redaelli, Stefano; Fitterer, Miriam; Fiascaris, Maria; Nisbet, David; Thiesen, Hugues; Valentino, Gianluca; Xu, Chen; CERN. Geneva. ATS Department

2017-01-01

In this MD we performed halo excitation through tune ripple. This consists in an excitation that introduces new resonance sidebands around the existing resonance lines. In presence of sufficient detuning with amplitude, these sidebands can in principle affect only the dynamics of the halo particles at large amplitudes. Tune ripple was induced through a current modulation of the warm trim quadrupoles in IR7. This is the first time this method is experimentally tested at the LHC.

A Pilot Survey of Food Frequencies, Meal Frequencies and Meal Patterns of Preschool Children in East Los Angeles.

Science.gov (United States)

Lewis, Jane S.; And Others

The food frequency, meal frequency, and meal patterns of a group of Mexican American children attending Head Start in East Los Angeles and their siblings were studied. Fifty dietary questionnaires in English and in Spanish with written instructions were distributed to parents. Parents were asked to record for a 3 day period the eating time, type…

75 FR 31511 - Ideal Federal Savings Bank, Baltimore, MD; Approval of Conversion Application

Science.gov (United States)

2010-06-03

... DEPARTMENT OF THE TREASURY Office of Thrift Supervision [AC-46: OTS No. 08283] Ideal Federal Savings Bank, Baltimore, MD; Approval of Conversion Application Notice is hereby given that on May 24, 2010, the Office of Thrift Supervision approved the application of Ideal Federal Savings Bank...

75 FR 18056 - Safety Zone; Fireworks Display, Patuxent River, Solomons Island Harbor, MD

Science.gov (United States)

2010-04-09

... the event, and enhancing public and maritime safety. Basis and Purpose Fireworks displays are... promote public and maritime safety during a fireworks display, and to protect mariners transiting the area...-AA00 Safety Zone; Fireworks Display, Patuxent River, Solomons Island Harbor, MD AGENCY: Coast Guard...

77 FR 11434 - Safety Zone; Patapsco River, Northwest and Inner Harbors, Baltimore, MD

Science.gov (United States)

2012-02-27

...-AA00 Safety Zone; Patapsco River, Northwest and Inner Harbors, Baltimore, MD AGENCY: Coast Guard, DHS... intended route immediately prior to, during, and following the scheduled towing evolution, vessel traffic... made to the maritime community via marine information broadcasts so mariners may adjust their plans...

AngelStow: A Commercial Optimization-Based Decision Support Tool for Stowage Planning

DEFF Research Database (Denmark)

Delgado-Ortegon, Alberto; Jensen, Rune Møller; Guilbert, Nicolas

save port fees, optimize use of vessel capacity, and reduce bunker consumption. Stowage Coordinators (SCs) produce these plans manually with the help of graphical tools, but high-quality SPs are hard to generate with the limited support they provide. In this abstract, we introduce AngelStow which...... is a commercial optimization-based decision support tool for stowing container vessels developed in collaboration between Ange Optimization and The IT University of Copenhagen. The tool assists SCs in the process of generating SPs interactively, focusing on satisfying and optimizing constraints and objectives...... that are tedious to deal with for humans, while letting the SCs use their expertise to deal with hard combinatorial objectives and corner cases....

Report from LHC MD 2158: IR-nonlinear studies

CERN Document Server

Maclean, Ewen Hamish; Cruz Alaniz, Emilia; Dalena, Barbara; Dilly, Joschua Werner; Fol, Elena; Giovannozzi, Massimo; Hofer, Michael; Malina, Lukas; Persson, Tobias Hakan Bjorn; Coello De Portugal - Martinez Vazquez, Jaime Maria; Skowronski, Piotr Krzysztof; Solfaroli Camillocci, Matteo; Tomas Garcia, Rogelio; Garcia-Tabares Valdivieso, Ana; Wegscheider, Andreas; CERN. Geneva. ATS Department

2018-01-01

For the first time the LHC is running for luminosity-production with local corrections for nonlinear errors in the ATLAS and CMS insertions. While a major step forward in LHC optics commissioning strategy (and one which has yielded clear operational benefits) considerable challenges remain to be overcome, both in regard to the optimization of LHC optics and in order to ensure successful commissioning of the High-Luminosity LHC. MD 2158 sought to follow up several aspects of the 2017 nonlinear optics commissioning which are not yet understood, and by enhancing sextupole and dodecapole sources in the ATLAS and CMS insertions explore the prospects for linear and nonlinear optics commissioning in the HL-LHC.

[Failed transcatheter creation of fenestration in a Fontan patient with original fenestration closed by AngelWings septal occluder: a case report].

Science.gov (United States)

Ohno, Atsuko; Hirotaka, Ishido; Kobayashi, Toshiki; Asano, Haruhiko; Kyo, Shunei; Senzaki, Hideaki

2007-10-01

The fenestrated Fontan procedure has helped to reduce the mortality and morbidity of pediatric patients who underwent the Fontan operation. We treated a patient (7-year-old, female) who had developed heart failure 1 year after fenestration closure using an AngelWings device, although the patient met the proposed criteria for test occlusion. Hemodynamic evaluation using the ventricular pressure-area relationship revealed that the patient had both systolic and diastolic dysfunction, which were difficult to recognize by conventional hemodynamic indices. We then tried to percutaneously create a fenestration using a Brockenbrough needle, but this procedure failed. The AngelWings device, which may have been covered by pseudointima (composed of fibroelastic tissue), was hard enough to break the Brockenbrough needle. Re-creating a fenestration after device closure in patients after the fenestrated Fontan operation appears to be difficult, so more accurate methods to predict Fontan physiology after fenestration closure are needed.

Virtual synthesis of crystals using ab initio MD: Case study on LiFePO4

Science.gov (United States)

Mishra, S. B.; Nanda, B. R. K.

2017-05-01

Molecular dynamics simulation technique is fairly successful in studying the structural aspects and dynamics of fluids. Here we study the ability of ab initio molecular dynamics (ab initio MD) to carry out virtual experiments to synthesize new crystalline materials and to predict their structures. For this purpose the olivine phosphate LiFePO4 (LFPO) is used as an example. As transition metal oxides in general are stabilized with layered geometry, we carried out ab initio MD simulations over a hypothetical layered configuration consisting of alternate LiPO2 and FeO2 layers. With intermittent steps of electron minimization, the resulted equilibrium lattice consist of PO4 tetrahedra and distorted Fe-O complexes similar to the one observed in the experimental lattice.

The Record Los Angeles Heat Event of September 2010: 1. Synoptic-Scale-Meso-β-Scale Analyses of Interactive Planetary Wave Breaking, Terrain- and Coastal-Induced Circulations

Science.gov (United States)

Kaplan, Michael L.; Tilley, Jeffrey S.; Hatchett, Benjamin J.; Smith, Craig M.; Walston, Joshua M.; Shourd, Kacie N.; Lewis, John M.

2017-10-01

On 27 September 2010 the Los Angeles Civic Center reached its all-time record maximum temperature of 45°C before 1330 local daylight time with several other regional stations observing all-time record breaking heat early in that afternoon. This record event is associated with a general circulation pattern predisposed to hemispheric wave breaking. Three days before the event, wave breaking organizes complex terrain- and coastal-induced processes that lead to isentropic surface folding into the Los Angeles Basin. The first wave break occurs over the western two thirds of North America leading to trough elongation across the southwestern U.S. Collocated with this trough is an isentropic potential vorticity filament that is the locus of a thermally indirect circulation central to warming and associated thickness increases and ridging westward across the Great Basin. In response to this circulation, two subsynoptic wave breaks are triggered along the Pacific coast. The isentropic potential vorticity filament is coupled to the breaking waves and the interaction produces a subsynoptic low-pressure center and a deep vortex aloft over the southeastern California desert. This coupling leads to advection of an elevated mixed layer over Point Conception the night before the record-breaking heat that creates a coastally trapped low-pressure area southwest of Los Angeles. The two low-pressure centers create a low-level pressure gradient and east-southeasterly jet directed offshore over the Los Angeles Basin by sunrise on 27 September. This allows the advection of low-level warm air from the inland terrain toward the coastally trapped disturbance and descending circulation resulting in record heating.

Cellular Energy Pathways as Novel Targets for the Therapy of Autosomal Dominant Polycystic Kidney Disease

Science.gov (United States)

2016-09-01

pathways that are involved in cyst development and expansion. These experiments will make use of cultured ADPKD cells and a mouse model of ADPKD to...AWARD NUMBER: W81XWH-15-1-0420 TITLE: Cellular Energy Pathways as Novel Targets for the Therapy of Autosomal Dominant Polycystic Kidney Disease...PRINCIPAL INVESTIGATOR: Kenneth R. Hallows, MD, PhD, FASN CONTRACTING ORGANIZATION: University of Southern California Los Angeles, CA 90089-0701

Facilitators and barriers to implementing a local policy to reduce sodium consumption in the County of Los Angeles government, California, 2009.

Science.gov (United States)

Gase, Lauren N; Kuo, Tony; Dunet, Diane O; Simon, Paul A

2011-03-01

This qualitative study explores facilitators and barriers to a proposed food procurement policy that would require food purchasers, distributors, and vendors of food service in the County of Los Angeles government to meet specified nutrition standards, including limits on sodium content. We conducted 30 key informant interviews. Interviewees represented 18 organizations from the County of Los Angeles government departments that purchased, distributed, or sold food; public and private non-County entities that had previously implemented food procurement policies in their organizations; and large organizations that catered food to the County. Study participants reported 3 key facilitators: their organization's authority to impose nutrition standards, their organization's desire to provide nutritious food, and the opportunity to build on existing nutrition policies. Eight key barriers were identified: 1) unique features among food service settings, 2) costs and unavailability of low-sodium foods, 3) complexity of food service arrangements, 4) lack of consumer demand for low-sodium foods, 5) undesirable taste of low-sodium foods, 6) preference for prepackaged products, 7) lack of knowledge and experience in operationalizing sodium standards, and 8) existing multiyear contracts that are difficult to change. Despite perceived barriers, several participants indicated that their organizations have successfully implemented nutritional standards that include limits on sodium. Developing or changing policies for procuring food represents a potentially feasible strategy for reducing sodium consumption in food service venues controlled by the County of Los Angeles. The facilitators and barriers identified here can inform the formulation, adoption, implementation, and evaluation of sodium reduction policies in other jurisdictions.

Multiple Imputation of Groundwater Data to Evaluate Spatial and Temporal Anthropogenic Influences on Subsurface Water Fluxes in Los Angeles, CA

Science.gov (United States)

Manago, K. F.; Hogue, T. S.; Hering, A. S.

2014-12-01

In the City of Los Angeles, groundwater accounts for 11% of the total water supply on average, and 30% during drought years. Due to ongoing drought in California, increased reliance on local water supply highlights the need for better understanding of regional groundwater dynamics and estimating sustainable groundwater supply. However, in an urban setting, such as Los Angeles, understanding or modeling groundwater levels is extremely complicated due to various anthropogenic influences such as groundwater pumping, artificial recharge, landscape irrigation, leaking infrastructure, seawater intrusion, and extensive impervious surfaces. This study analyzes anthropogenic effects on groundwater levels using groundwater monitoring well data from the County of Los Angeles Department of Public Works. The groundwater data is irregularly sampled with large gaps between samples, resulting in a sparsely populated dataset. A multiple imputation method is used to fill the missing data, allowing for multiple ensembles and improved error estimates. The filled data is interpolated to create spatial groundwater maps utilizing information from all wells. The groundwater data is evaluated at a monthly time step over the last several decades to analyze the effect of land cover and identify other influencing factors on groundwater levels spatially and temporally. Preliminary results show irrigated parks have the largest influence on groundwater fluctuations, resulting in large seasonal changes, exceeding changes in spreading grounds. It is assumed that these fluctuations are caused by watering practices required to sustain non-native vegetation. Conversely, high intensity urbanized areas resulted in muted groundwater fluctuations and behavior decoupling from climate patterns. Results provides improved understanding of anthropogenic effects on groundwater levels in addition to providing high quality datasets for validation of regional groundwater models.

Going Concern Opinions and Management's Forward Looking Disclosures: Evidence from the MD&A

NARCIS (Netherlands)

Enev, M.; Geiger, Marshall; Gold, A.H.; Wallage, P.

In this study we examine the relationship between the auditor’s going concern opinion and management’s forward-looking disclosures in the Management’s Discussion and Analysis (MD&A) section of 10-K filings. The research objective is two-fold and addresses whether the presence of a going concern

77 FR 42179 - Safety Zone; Fireworks Display, Potomac River, Charles County, Newburg, MD

Science.gov (United States)

2012-07-18

...]30[sec] W, located at Newburg in Charles County, Maryland (NAD 1983). The temporary safety zone will... 1625-AA00 Safety Zone; Fireworks Display, Potomac River, Charles County, Newburg, MD AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard will establish a safety zone upon...

"That was Heaven". Hadrian's Villa as "fabulous" Heaven in Angels in America by Mike Nichols

Directory of Open Access Journals (Sweden)

Mauro Giori

2011-07-01

Full Text Available Angels in America is still Tony Kushner’s major achievement. In adapting it for television, Mike Nichols accurately respected the political agenda of the author (democratic, hebrew and homosexual, who also wrote the screenplay. The choice of Hadrian’s Villa (instead of a San Francisco devastated by the earthquake of 1906 as a background for the scenes which take place in the Paradise can be understood as coherent with Kushner’s ideological perspective, as well as with his original camp aesthetics.

Examining Summer Laboratory Research Apprenticeships for High School Students as a Factor in Entry to MD/PhD Programs at Matriculation

Science.gov (United States)

Tai, Robert H.; Kong, Xiaoqing; Mitchell, Claire E.; Dabney, Katherine P.; Read, Daniel M.; Jeffe, Donna B.; Andriole, Dorothy A.; Wathington, Heather D.

2017-01-01

Do summer laboratory research apprenticeships during high school have an impact on entry into MD/PhD programs? Apart from the nearly decade-long span of time between high school and matriculation into an MD/PhD program, young people have many life-shaping experiences that presumably impact their education and career trajectories. This quantitative…

78 FR 32556 - Safety Zone; 2013 Ocean City Air Show, Atlantic Ocean; Ocean City, MD

Science.gov (United States)

2013-05-31

... FR Federal Register NPRM Notice of Proposed Rulemaking A. Regulatory History and Information The... Atlantic Ocean in Ocean City, MD. In recent years, there have been unfortunate instances of jets and planes...

Annual West Coast Theoretical Chemistry/Statistical Mechanics Conference (14th), held at Los Angeles, California on 17-19 June 1993

Science.gov (United States)

1993-06-19

personic (> Mach 2) aircraft. Since these aircraft will fly through the stratosphere, there is considerable concern about NO. emissions from the jet...stabilize the 6-endo ring opening. acid HHO Ar Ar HH AA Arr t University of California, Los Angeles. SScripps Research Institute. 10o1 Poster Session HI

75 FR 17562 - Port Access Route Study: In the Approaches to Los Angeles-Long Beach and in the Santa Barbara...

Science.gov (United States)

2010-04-07

... or dangerous. Vessel routing system means any system of one or more routes or routing measure aimed... approaches to Los Angeles-Long Beach and the approach to the San Pedro Channel from the Pacific Ocean... are most cost- effective? 5. What impacts, both positive and negative, would changes to existing...

75 FR 51945 - Safety Zone; Potomac River, St. Mary's River, St. Inigoes, MD

Science.gov (United States)

2010-08-24

...-AA00 Safety Zone; Potomac River, St. Mary's River, St. Inigoes, MD AGENCY: Coast Guard, DHS. ACTION... of the St. Mary's River, a tributary of the Potomac River. This action is necessary to provide for.... Navy helicopter located near St. Inigoes, Maryland. This safety zone is intended to protect the...

Notes from the field: identification of a Taenia tapeworm carrier - Los Angeles County, 2014.

Science.gov (United States)

Croker, Curtis; Soriano, Jan; Civen, Rachel; Larsen, Robert A; Schwartz, Benjamin

2015-01-30

Carriers of the pork tapeworm, Taenia solium, are the sole source of cysticercosis, a parasitic tissue infection. When tapeworm eggs excreted by the carrier are ingested, tapeworm larvae can form cysts. When cysts form in the brain, the condition is called neurocysticercosis and can be especially severe. In Los Angeles County an average of 136 county residents are hospitalized with neurocysticercosis each year. The prevalence of Taenia solium carriage is largely unknown because carriage is asymptomatic, making detection difficult. The identification and treatment of tapeworm carriers is an important public health measure that can prevent additional neurocysticercosis cases.

Analysis of the Effects of ENSO and Atmospheric Rivers on Precipitation in Los Angeles County

Science.gov (United States)

Santacruz, A.; Lamb, K.

2017-12-01

The Winter 2016-2017 season in California was marked by substantial amounts of precipitation; this resulted in critically-low reservoirs filling up and the removal of most of California from drought status. The year prior was characterized by one of the strongest El Nino-Southern Oscillation (ENSO) events, though it did not produce nearly enough precipitation as the 2016-2017 season. The major contributors to the increased rainfall during the 2016-2017 season were climactic phenomenon known as atmospheric rivers (ARs), which transport water vapor through the atmosphere in narrow bands, and are known to produce extreme rain events. Determining the exact timing, landfall areas, and total precipitation amounts of ARs is currently of great interest; a recent study showed that extreme weather events are likely to increase in California in the coming years, which motivates research into how phenomenon such as ENSO and ARs play a role. Using long-term daily rain gauge data provided by the Los Angeles County Department of Public Works, we compute the precipitation volume and storm count for various locations in Los Angeles County and identify anomalies. These data will then be compared with the occurrence and intensity of AR and ENSO events by using NOAA's NOI and ESRL AR data. The results can be used to provide a better grasp of extreme climactic patterns and their effects on the amount of precipitation in the region.

MD 979: Beta-beating measurements on colliding beams

CERN Document Server

Goncalves Jorge, Patrik; Pieloni, Tatiana; Buffat, Xavier; Carlier, Felix Simon; Coello De Portugal - Martinez Vazquez, Jaime Maria; Fol, Elena; Langner, Andy Sven; Medina Medrano, Luis Eduardo; Olexa, Jakub; Tomas Garcia, Rogelio; Valuch, Daniel; Wegscheider, Andreas; CERN. Geneva. ATS Department

2017-01-01

The HL-LHC high brightness beams will give a large β-beating due to the head-on and long-range interactions since a beam-beam parameter of 0.01 per Interaction Point (IP) is expected. The β-heating induced by two head-on collision reaches 15%. A third IP, i.e. IP8, could bring the β-heating up to 24%. The aim of the Machine Development (MD) study was to test optics measurements with AC dipole and ADT on colliding beams at injection and to implement a correction of the β-heating due to to head-on collision in the two experiments IP1&5. Int his note, we summarize the first results of this test performed in the LHC.

A virtual observatory for photoionized nebulae: the Mexican Million Models database (3MdB).

Science.gov (United States)

Morisset, C.; Delgado-Inglada, G.; Flores-Fajardo, N.

2015-04-01

Photoionization models obtained with numerical codes are widely used to study the physics of the interstellar medium (planetary nebulae, HII regions, etc). Grids of models are performed to understand the effects of the different parameters used to describe the regions on the observables (mainly emission line intensities). Most of the time, only a small part of the computed results of such grids are published, and they are sometimes hard to obtain in a user-friendly format. We present here the Mexican Million Models dataBase (3MdB), an effort to resolve both of these issues in the form of a database of photoionization models, easily accessible through the MySQL protocol, and containing a lot of useful outputs from the models, such as the intensities of 178 emission lines, the ionic fractions of all the ions, etc. Some examples of the use of the 3MdB are also presented.

Discovering and Developing Successful Cardiovascular Therapeutics: A Conversation With James N. Topper, MD, PhD.

Science.gov (United States)

Topper, James N; Rutherford, John D

2016-11-15

Dr James (also known as Jamie) N. Topper, MD, PhD, serves as Managing General Partner at Frazier Healthcare Partners, where he leads the Life Science Venture practice. In 2011, and 2016, he was named to the Midas List of leading venture capitalists, and, in 2013, he was recognized by Forbes as one of the top 10 healthcare investors. He has >25 years of experience working with entrepreneurs to found and build successful therapeutics-focused companies. Dr Topper holds a BS from the University of Michigan. He received an MD and PhD (in biophysics) from Stanford University School of Medicine. He completed postgraduate training in internal medicine and cardiovascular disease at the Brigham and Women's Hospital in Boston and is board certified in both disciplines. © 2016 American Heart Association, Inc.

Pharmacokinetics and pharmacodynamics of MD1003 (high-dose biotin) in the treatment of progressive multiple sclerosis.

Science.gov (United States)

Peyro Saint Paul, Laure; Debruyne, Danièle; Bernard, Delphine; Mock, Donald M; Defer, Gilles L

2016-01-01

Multiple sclerosis (MS) is a chronic, potentially highly disabling neurological disorder. No disease-modifying treatments are approved in the progressive and not active forms of the disease. High doses of biotin were tested in an open-label pilot study involving 23 patients with progressive MS and reported positive results. A randomized, double-blind, placebo-controlled trial in 154 progressive MS patients confirmed the beneficial effect of MD1003 (high-dose biotin) on reversing or stabilizing disability progression, with a good safety profile. It is proposed that MD1003 in progressive MS 1) increases energy production in demyelinated axons and/or 2) enhances myelin synthesis in oligodendrocytes. Biotin is highly bioavailable; absorption and excretion are rapid. The major route of elimination is urinary excretion. A high oral dose of biotin seems generally well tolerated but a few important safety concerns were identified: 1) teratogenicity in one species and 2) interference with some biotin-based laboratory immunoassays. The animal toxicity data are limited at such high doses. Further preclinical studies would be useful to address the mechanism of action of MD1003. Assessment of clinical benefit duration in responders will be also very important to set. Results of randomized, placebo-controlled trial are reassuring and provide hope for the treatment of progressive MS.

Network Correlates of Sexual Health Advice Seeking and Substance Use among Members of the Los Angeles House and Ball Communities

Science.gov (United States)

Holloway, Ian W.; Schrager, Sheree M.; Wong, Carolyn F.; Dunlap, Shannon L.; Kipke, Michele D.

2014-01-01

House and Ball communities (HBCs), represent a prime context for human immunodeficiency virus prevention with African American young men who have sex with men and transgender persons. This study sought to understand the composition and function of social support and sexual networks of HBC members in Los Angeles, California (N = 263). Participants…

HB D Los Angeles in a Brazilian family Hb D Los Angeles em família brasileira

Directory of Open Access Journals (Sweden)

Guilherme G. Leoneli

2001-09-01

Full Text Available Inherited disorders of hemoglobin, the most common monogenic disease, are now well understood at the molecular level, knowledge, which has led to considerable improvements in their control and management. The Brazilian population is multiethnic, and the correct characterization of the Hb D is important, mainly because the method available for detection of abnormal hemoglobins, present a migration in the same zone at alkaline pH, for Hb S, D, and G for example. In this paper we studied a family with an abnormal hemoglobin like S in alkaline electrophoresis, by appropriated methods including HPLC and molecular analysis, characterized as hemoglobin D Los Angeles.As doenças hereditária da hemoglobina são as mais comuns doenças monogênicas e atualmente bem conhecidas do ponto de vista molecular, fato este que propiciou um avanço no seu controle e manuseio. A população brasileira caracteriza-se pela multiplicidade étnica e a caracterização da Hb D torna-se importante por este dado, associado ao fato de que os métodos de detecção das hemoglobinopatias comumente não identificam esta fração anormal que apresenta a peculiaridade de migração eletroforéticia em pH alcalino na mesma zona observada nas Hb S e G. Neste relato é apresentado um estudo familiar no qual é empregada metodologia adequada, o HLPC, que permite a identificação da Hb D.

Property Analysis of Exfoliated Graphite Nanoplatelets Modified Asphalt Model Using Molecular Dynamics (MD Method

Directory of Open Access Journals (Sweden)

Hui Yao

2017-01-01

Full Text Available This Molecular Dynamics (MD simulation paper presents a physical property comparison study between exfoliated graphite nanoplatelets (xGNP modified and control asphalt models, including density, glass transition temperature, viscosity and thermal conductivity. The three-component control asphalt model consists of asphaltenes, aromatics, and saturates based on previous references. The xGNP asphalt model was built by incorporating an xGNP and control asphalt model and controlling mass ratios to represent the laboratory prepared samples. The Amber Cornell Extension Force Field (ACEFF was used with assigned molecular electro-static potential (ESP charge from NWChem analysis. After optimization and ensemble relaxation, the properties of the control and xGNP modified asphalt models were computed and analyzed using the MD method. The MD simulated results have a similar trend as the test results. The property analysis showed that: (1 the density of the xGNP modified model is higher than that of the control model; (2 the glass transition temperature of the xGNP modified model is closer to the laboratory data of the Strategic Highway Research Program (SHRP asphalt binders than that of the control model; (3 the viscosities of the xGNP modified model at different temperatures are higher than those of the control model, and it coincides with the trend in the laboratory data; (4 the thermal conductivities of the xGNP modified asphalt model are higher than those of the control asphalt model at different temperatures, and it is consistent with the trend in the laboratory data.

Radioprotective and radiotherapeutic properties of biotechnological agent MD2

International Nuclear Information System (INIS)

Sobol, C.V.; Komar, V.E.; Sobol, Y.T.

1996-01-01

In recent years as the result of nuclear testing and accidents at nuclear power plants such as Chernobyl, etc. radiation exposure has become a major issue in various parts of the world. Experience of recent nuclear accidents has shown there is no effective treatment for patients expose to doses of radiation that result in fatal hematopoietic failure and /or secondary infections. Therefore, agents that are effective when administered after irradiation, are of great interest. In this study, the possibility of using biotechnological agent MD2 after lethal total body irradiation (TBI) and radiotherapy has been demonstrated. In addition, the considerable radioprotection without toxic effect can be obtained. (author)

A molecular dynamics (MD simulation on tire-aggregate friction

Directory of Open Access Journals (Sweden)

Fengyan Sun

2017-07-01

Full Text Available The friction between tire and road surface is fundamentally depending on the molecular forces. In this paper, the nanoscale 3D contact model is employed to investigate the tire-aggregate friction mechanism. The tire and aggregate micro-structure are both constructed to evaluate the microscopic performance of tire-aggregate friction influence. Simulation results show for a high velocity, the energy dissipation of sliding on crystal structure is small, which results in a small friction coefficient; temperature will have influences on the friction coefficient, and with the increasing of velocity, the effect will gradually reduce. Keywords: Tire, Aggregate, Friction coefficient, Microscopic mechanism, MD simulation

76 FR 9407 - Fraternity Federal Savings & Loan Association, Baltimore, MD; Approval of Conversion Application

Science.gov (United States)

2011-02-17

... DEPARTMENT OF THE TREASURY Office of Thrift Supervision [AC-58 OTS No. 01292 and H 4762] Fraternity Federal Savings & Loan Association, Baltimore, MD; Approval of Conversion Application Notice is hereby given that on February 10, 2011, the Office of Thrift Supervision approved the application of...

76 FR 20008 - Notice of Temporary Concession Contract for Assateague Island National Seashore, MD

Science.gov (United States)

2011-04-11

... pre-packaged food and beverage. This action is necessary to avoid interruption of visitor services... DEPARTMENT OF THE INTERIOR National Park Service [NPS-WASO-CONC-0111-6544; 2410-OYC] Notice of Temporary Concession Contract for Assateague Island National Seashore, MD AGENCY: National Park Service...

Binding mode prediction and MD/MMPBSA-based free energy ranking for agonists of REV-ERBα/NCoR.

Science.gov (United States)

Westermaier, Yvonne; Ruiz-Carmona, Sergio; Theret, Isabelle; Perron-Sierra, Françoise; Poissonnet, Guillaume; Dacquet, Catherine; Boutin, Jean A; Ducrot, Pierre; Barril, Xavier

2017-08-01

The knowledge of the free energy of binding of small molecules to a macromolecular target is crucial in drug design as is the ability to predict the functional consequences of binding. We highlight how a molecular dynamics (MD)-based approach can be used to predict the free energy of small molecules, and to provide priorities for the synthesis and the validation via in vitro tests. Here, we study the dynamics and energetics of the nuclear receptor REV-ERBα with its co-repressor NCoR and 35 novel agonists. Our in silico approach combines molecular docking, molecular dynamics (MD), solvent-accessible surface area (SASA) and molecular mechanics poisson boltzmann surface area (MMPBSA) calculations. While docking yielded initial hints on the binding modes, their stability was assessed by MD. The SASA calculations revealed that the presence of the ligand led to a higher exposure of hydrophobic REV-ERB residues for NCoR recruitment. MMPBSA was very successful in ranking ligands by potency in a retrospective and prospective manner. Particularly, the prospective MMPBSA ranking-based validations for four compounds, three predicted to be active and one weakly active, were confirmed experimentally.

MD 2408: Study of Schottky Monitors for Q' Measurement at Injection

CERN Document Server

Tydecks, Tobias; Levens, Tom; Wendt, Manfred; Wenninger, Jorg; CERN. Geneva. ATS Department

2018-01-01

The Schottky monitors installed at the LHC enable the detection of Schottky noise of the two circulating proton / ion beams. From Schottky noise, beam parameters like tune, chromaticity, and relative emittance, can be extracted in a non-destructive and purely parasitic method of measurement. The primary goal of this MD was to study the Schottky monitors capability to reliably and accurately determine the beam chromaticities at injection energy. Furthermore, the possibility to track the beam emittance has been investigated.

Influence of Code Size Variation on the Performance of 2D Hybrid ZCC/MD in OCDMA System

Directory of Open Access Journals (Sweden)

Matem Rima.

2018-01-01

Full Text Available Several two dimensional OCDMA have been developed in order to overcome many problems in optical network, enhancing cardinality, suppress Multiple Access Interference (MAI and mitigate Phase Induced Intensity Noise (PIIN. This paper propose a new 2D hybrid ZCC/MD code combining between 1D ZCC spectral encoding where M is its code length and 1D MD spatial spreading where N is its code length. The spatial spreading (N code length offers a good cardinality so it represents the main effect to enhance the performance of the system compared to the spectral (M code length according to the numerical results.

Leonard F. Peltier, MD, PhD, 1920-2003.

Science.gov (United States)

Reckling, Frederick W; Lo Vecchio, Janolyn G; Reckling, JoAnn B

2004-05-01

Leonard F. Peltier, MD, PhD, was an orthopaedic surgeon, academician, administrator, laboratory investigator, historian, and mentor. His career spanned nearly six decades, beginning with graduate education at the University of Minnesota (UM) under the auspices of Owen H. Wangensteen, MD, PhD. In addition to obtaining a PhD in physiology in the UM Graduate School, he completed general and orthopaedic surgery residencies and attained board certification in each specialty. He served in the US Army Occupation Force Medical Corps in Germany just after World War II. In 1957, at 37 years old, he assumed the chairmanship of the orthopaedic training program at the University of Kansas. In 1971, he couldn't resist the opportunity to become one of the founding members of the "start-up" University of Arizona College of Medicine, accepting an appointment as chair of the new orthopaedic training program, where he remained until his retirement in 1990. He took clinical problems to the laboratory, and made important scientific contributions, particularly in the area of fat embolism and in using calcium sulfate (plaster of Paris) to fill bone defects. He served on governing boards of national professional organizations and presided over the American Association for the Surgery of Trauma from 1980-1981. Throughout his career, he was fascinated by, and published extensively in, the history of medicine arena. Known fondly as "the professor" to many of his residents and colleagues, he had a pragmatic, honest, upbeat, and often humorous approach to life's challenges, valuing personal integrity above other virtues. He explored various eclectic interests far beyond his professional contributions while maintaining his family as a central priority. With his exemplary productivity and interests in the surgical and laboratory sciences, history of medicine, appreciation of fine arts, and perceptive and effective interactions with family, friends, patients, and colleagues, the memory of Leonard

PERSONAL, INDOOR, AND OUTDOOR CONCENTRATIONS OF PM2.5, PARTICULATE NITRATE, AND ELEMENTAL CARBON FOR INDIVIDUALS WITH COPD IN LOS ANGELES, CA

Science.gov (United States)

This study characterizes the personal, indoor, and outdoor concentrations of PM2.5 and the major components of PM2.5, including nitrate (NO3-), elemental carbon (EC), and the elements for individuals with chronic obstructive pulmonary disease (COPD) living in Los Angeles, CA. ...

Directory of Federal Contractors and Cognizant Audit Offices

Science.gov (United States)

1994-12-31

66TH ST NO LARGO FL 33543 8135462476 ADVANCED TECHNICAL CORPORATION 04231 702 1915 ARMACUST LOS ANGELES CA 90025 2134783561 ADVANCED TECHNOLOGIES INC...MAINTENANCE 03791 033 1301 MONTE LARGO N. ALBUQUERQUE NM 87112 5052938075 ANTENNA ASSOCIATES INC 02181 023 21 BURKE DRIVE BROCKTON MA 02401 0000000000 ANTENNA...CENTER 01641 465 5151 BLAZER MEMORIA DUBLIN ON 43017 6147645454 AT&T FEDERAL SYSTEMS 06221 002 8403 COLESVILLE ROA SILVER SPRING MD 20910 3016064000 AT

Breast Cancer Research Training Grant

Science.gov (United States)

1999-03-01

Pharmacological Sciences, Lab. of Toxicology, Milano, Italy. presence of serum for 16 hr to enhance or deplete GSH levels before BaP Tributyltin ( TBT ...Holladay, S. D., and Smith. B. J. (1995). Alterations in murine fetal thymus Nebert. D. W., Jensen. N. M., Levitt, R. C., and Felton. J. S. (1980). Toxic ...Hungerford. Johns Hopkins University. Baltimore. MD 21239 Toxic -il. Univ. of South. Cal., Los Angeles.CA90033 Propagationofllcho-ndrocytes in microcarrier

Strong to fragile transition in a model of liquid silica

OpenAIRE

Barrat, Jean-Louis; Badro, James; Gillet, Philippe

1996-01-01

The transport properties of an ionic model for liquid silica at high temperatures and pressure are investigated using molecular dynamics simulations. With increasing pressure, a clear change from "strong" to "fragile" behaviour (according to Angell's classification of glass-forming liquids) is observed, albeit only on the small viscosity range that can be explored in MD simulations.. This change is related to structural changes, from an almost perfect four-fold coordination to an imperfect fi...

75 FR 51333 - Madison Square Federal Savings Bank, Baltimore, MD; Approval of Conversion Application

Science.gov (United States)

2010-08-19

... DEPARTMENT OF THE TREASURY Office of Thrift Supervision [AC-49: OTS Nos. 08156 and H4736] Madison Square Federal Savings Bank, Baltimore, MD; Approval of Conversion Application Notice is hereby given that on August 12, 2010, the Office of Thrift Supervision approved the application of Madison Square...

75 FR 50878 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

Science.gov (United States)

2010-08-18

... Airworthiness Directives; McDonnell Douglas Corporation Model MD- 90-30 Airplanes AGENCY: Federal Aviation... McDonnell Douglas Corporation: Amendment 39-16388. Docket No. FAA-2010-0433; Directorate Identifier 2009-NM..., 2010. Affected ADs (b) None. Applicability (c) This AD applies to McDonnell Douglas Corporation Model...

75 FR 68245 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

Science.gov (United States)

2010-11-05

...-1043; Directorate Identifier 2010-NM-200-AD] RIN 2120-AA64 Airworthiness Directives; McDonnell Douglas... McDonnell Douglas Model MD-90-30 airplanes. This proposed AD would require installing new fire handle... airworthiness directive (AD): McDonnell Douglas Corporation: Docket No. FAA-2010-1043; Directorate Identifier...

75 FR 80742 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

Science.gov (United States)

2010-12-23

...-1202; Directorate Identifier 2010-NM-167-AD] RIN 2120-AA64 Airworthiness Directives; McDonnell Douglas... amends Sec. 39.13 by adding the following new airworthiness directive (AD): McDonnell Douglas Corporation... Douglas Corporation Model MD-90-30 airplanes, certificated in any category. Subject (d) Joint Aircraft...

Security concept in 'MyAngelWeb' a website for the individual patient at risk of emergency.

Science.gov (United States)

Pinciroli, F; Nahaissi, D; Boschini, M; Ferrari, R; Meloni, G; Camnasio, M; Spaggiari, P; Carnerone, G

2000-11-01

We describe the Security Plan for the 'MyAngelWeb' service. The different actors involved in the service are subject to different security procedures. The core of the security system is implemented at the host site by means of a DBMS and standard Information Technology tools. Hardware requirements for sustainable security are needed at the web-site construction sites. They are not needed at the emergency physician's site. At the emergency physician's site, a two-way authentication system (password and test phrase method) is implemented.

A Health Probe in College Students Living in Los Angeles and in Taiwan: Dietary Pattern, Physical Activity and Energy Balance

Science.gov (United States)

Wang, Li Hui; Yang, Hsin Ling; Chen, Yin Chang; Davis, Rebecca; Schwartz, Miriam E.; Tam, Chick F.

2008-01-01

The objective was to examine differences of dietary pattern, physical activity and energy balance in 240 college students with 137 of them enrolled in California State University, Los Angeles (LA) and the other 93 enrolled in China Medical University in Taichung, Taiwan (TW). A three-day dietary record and a 24-hour physical activity journal were…

MD-11 PCA - First Landing at Edwards

Science.gov (United States)

1995-01-01

This McDonnell Douglas MD-11 approaches the first landing ever of a transport aircraft under engine power only on Aug. 29, 1995, at NASA's Dryden Flight Research Center, Edwards, California. The milestone flight, flown by NASA research pilot and former astronaut Gordon Fullerton, was part of a NASA project to develop a computer-assisted engine control system that enables a pilot to land a plane safely when it normal control surfaces are disabled. The Propulsion-Controlled Aircraft (PCA) system uses standard autopilot controls already present in the cockpit, together with the new programming in the aircraft's flight control computers. The PCA concept is simple--for pitch control, the program increases thrust to climb and reduces thrust to descend. To turn right, the autopilot increases the left engine thrust while decreasing the right engine thrust. The initial Propulsion-Controlled Aircraft studies by NASA were carried out at Dryden with a modified twin-engine F-15 research aircraft.

The origins of the Olympic Village: Los Angeles 1932 and Berlin 1936.

Directory of Open Access Journals (Sweden)

Massimo Bortolotti

2009-06-01

Full Text Available Regarding the transformations produced by the housing projects for the Olympic Games, the construction and following reuse of the Olympic Villages is an interesting studying matter. During the hundred-year-old history of the modern Olympics the realization of the Olympic Village, which finds reference in the de Coubertin’s writings, and the town planning transformations, to this correlated, have revealed in different ways. The essay mainly concerns the origins of the Olympic Village and the first settlements which characterized the Games in the thirties: Los Angeles 1932 and Berlin 1936. In these two cities, even though with different motivations, politico-economical stimulus and different images, the prototypes of the modern Olympic sport facilities, which find in the village an in the stadium the symbol of the event, were born.

A Gravity data along LARSE (Los Angeles Regional Seismic Experiment) Line II, Southern California

Science.gov (United States)

Wooley, R.J.; Langenheim, V.E.

2001-01-01

The U.S. Geological Survey conducted a detailed gravity study along part of the Los Angeles Regional Seismic Experiment (LARSE) transect across the San Fernando Basin and Transverse Ranges to help characterize the structure underlying this area. 249 gravity measurements were collected along the transect and to augment regional coverage near the profile. An isostatic gravity low of 50-60 mGal reflects the San Fernando-East Ventura basin. Another prominent isostatic gravity with an amplitude of 30 mGal marks the Antelope Valley basin. Gravity highs occur over the Santa Monica Mountains and the Transverse Ranges. The highest isostatic gravity values coincide with outcrops of Pelona schist.

75 FR 21528 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

Science.gov (United States)

2010-04-26

...-0433; Directorate Identifier 2009-NM-117-AD] RIN 2120-AA64 Airworthiness Directives; McDonnell Douglas... main landing gear (MLG) during gear extension, damaging the hydraulic system on McDonnell Douglas.... The retract cylinder support fittings for the MLG on McDonnell Douglas Model MD-80 series airplanes...

75 FR 36577 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

Science.gov (United States)

2010-06-28

... Airworthiness Directives; McDonnell Douglas Corporation Model MD- 90-30 Airplanes AGENCY: Federal Aviation... Douglas Corporation: Docket No. FAA-2010-0554; Directorate Identifier 2010-NM-082-AD. Comments Due Date (a... supersedes AD 2009-07-04, Amendment 39-15863. Applicability (c) This AD applies to McDonnell Douglas...

Dynamics of biopolymers on nanomaterials studied by quasielastic neutron scattering and MD simulations

Science.gov (United States)

Dhindsa, Gurpreet K.

Neutron scattering has been proved to be a powerful tool to study the dynamics of biological systems under various conditions. This thesis intends to utilize neutron scattering techniques, combining with MD simulations, to develop fundamental understanding of several biologically interesting systems. Our systems include a drug delivery system containing Nanodiamonds with nucleic acid (RNA), and two specific model proteins, beta-Casein and Inorganic Pyrophosphatase (IPPase). RNA and nanodiamond (ND) both are suitable for drug-delivery applications in nano-biotechnology. The architecturally flexible RNA with catalytic functionality forms nanocomposites that can treat life-threatening diseases. The non-toxic ND has excellent mechanical and optical properties and functionalizable high surface area, and thus actively considered for biomedical applications. In this thesis, we utilized two tools, quasielastic neutron scattering (QENS) and Molecular Dynamics Simulations to probe the effect of ND on RNA dynamics. Our work provides fundamental understanding of how hydrated RNA motions are affected in the RNA-ND nanocomposites. From the experimental and Molecular Dynamics Simulation (MD), we found that hydrated RNA motion is faster on ND surface than a freestanding one. MD Simulation results showed that the failure of Stokes Einstein relation results the presence of dynamic heterogeneities in the biomacromolecules. Radial pair distribution function from MD Simulation confirmed that the hydrophilic nature of ND attracts more water than RNA results the de-confinement of RNA on ND. Therefore, RNA exhibits faster motion in the presence of ND than freestanding RNA. In the second project, we studied the dynamics of a natively disordered protein beta-Casein which lacks secondary structures. In this study, the temperature and hydration effects on the dynamics of beta-Casein are explored by Quasielastic Neutron Scattering (QENS). We investigated the mean square displacement (MSD) of

Non-linear beam dynamics tests in the LHC: LHC dynamic aperture MD on Beam 2 (24th of June 2012)

CERN Document Server

Maclean, E H; Persson, T H B; Redaelli, S; Schmidt, F; Tomas, R; Uythoven, J

2013-01-01

This MD note summarizes measurements performed on LHC Beam 2 during the non-linear machine development (MD) of 24 June 2012. The aim of the measurement was to observe the dynamic aperture of LHC Beam 2, and obtain turn-by-turn (TbT) betatron oscillation data, enabling the study of amplitude detuning and resonance driving terms (RDTs). The regular injections required by the MD also represented an opportunity to test a new coupling feedback routine based on the analysis of injection oscillation data. Initial measurements were performed on the nominal state of the LHC at injection. On completion of this study the Landau octupoles were turned off and corrections for higher-order chromaticities were implemented to reduce the non-linearity of the machine as far as possible. A second set of measurements were then performed. All studies were performed using the LHC aperture kicker (MKA).

MD study of pyrimidine base damage on DNA and its recognition by repair enzyme

International Nuclear Information System (INIS)

Pinak, M.

2000-01-01

The molecular dynamics (MD) simulation was used on the study of two specific damages of pyrimidine bases of DNA. Pyrimidine bases are major targets either of free radicals induced by ionizing radiation in DNA surrounding environment or UV radiation. Thymine dimer (TD) is UV induced damage, in which two neighboring thymines in one strand are joined by covalent bonds of C(5)-C(5) and C(6)-C(6) atoms of thymines. Thymine glycol (TG) is ionizing radiation induced damage in which the free water radical adds to unsaturated bond C(5)-C(6) of thymine. Both damages are experimentally suggested to be mutagenetic and carcinogenic unless properly repaired by repair enzymes. In the case of MD of TD, there is detected strong kink around the TD site that is not observed in native DNA. In addition there is observed the different value of electrostatic energy at the TD site - negative '-10 kcal/mol', in contrary to nearly neutral value of native thymine site. Structural changes and specific electrostatic energy - seems to be important for proper recognition of TD damaged site, formation of DNA-enzyme complex and thus for subsequent repair of DNA. In the case of TG damaged DNA there is major structural distortion at the TG site, mainly the increased distance between TG and the C5' of adjacent nucleotide. This enlarged gap between the neighboring nucleotides may prevent the insertion of complementary base during replication causing the replication process to stop. In which extend this structural feature together with energy properties of TG contributes to the proper recognition of TG by repair enzyme Endonuclease III is subject of further computational MD study. (author)

LHC β*-reach MD: aperture measurements at small β*

CERN Document Server

Fuster Martinez, Nuria; Redaelli, Stefano; CERN. Geneva. ATS Department

2017-01-01

During this MD, performed on the 25th of July 2017, we measured the LHC aperture at top energy for β*=30 cm using the Transverse Damper (ADT) blow-up method. These measurements are part of the standard commissioning of an optics and have been performed in order to provide early on inputs for a possible change of β* later in 2017, as envisaged previously to fully profit from the additional margins introduced by the rematched phase advance between dump kickers and the TCTs (Target Collimator Tertiary). In addition to the aperture measurements, two other commissioning important tests were performed: loss maps for the nominal TCTs settings and an asynchronous dump validation with tighter TCT gaps.

Lagoon microbialites on Isla Angel de la Guarda and associated peninsular shores, Gulf of California (Mexico)

Science.gov (United States)

Johnson, Markes E.; Ledesma-Vázquez, Jorge; Backus, David H.; González, Maria R.

2012-07-01

Examples of two closed lagoons with extensive growth of Recent microbialites showing variable surface morphology and internal structure are found on Isla Angel de la Guarda in the Gulf of California. Comparable lagoonal microbialites also occur ashore from Ensenada El Quemado on the adjacent peninsular mainland of Baja California. The perimeters of all three lagoons feature crusted structures indicative of thrombolites with a knobby surface morphology 2 cm to 3 cm in relief and internal clotting without any sign of laminations. Outward from this zone, thrombolitic construction thins to merge with a white calcified crust below which a soft substratum of dark organic material 4 cm to 6 cm in thickness is concealed. The substratum is laminated and heavily mucilaginous, as observed along the edges of extensive shrinkage cracks in the overlying crust. The thrombolitic crust is anchored to the shore, while the thinner crust and associated stromatolitic mats float on the surface of the lagoons. Laboratory cultures of the dark organic material yielded the solitary cyanobacterium Chroococcidiopsis as the predominant taxon interspersed with filamentous forms. In decreasing order of abundance, other morphotypes present include Phormidium, Oscillatoria, Geitlerinema, Chroococus, and probably Spirulina. The larger of the two island lagoons follows an east-west azimuth and covers 0.225 km2, while the smaller lagoon has a roughly north-south axis and covers only 0.023 km2. The salinity of water in the smaller lagoon was measured as148 ppt. Pliocene strata along the edge of the smaller modern lagoon include siltstone bearing calcified platelets suggestive of a microbial origin. Dry lagoons abandoned during the later Quaternary occur inland at higher elevations on the island, but retain no fossils except for sporadic white crusts cemented on cobbles around distinct margins. Raised Quaternary lagoons parallel to the big lagoon on Isla Angel de la Guarda are partly obscured by flood

Public awareness of and support for infrastructure changes designed to increase walking and biking in Los Angeles County.

Science.gov (United States)

Gase, Lauren N; Barragan, Noel C; Simon, Paul A; Jackson, Richard J; Kuo, Tony

2015-03-01

Policies to promote active transportation are emerging as a best practice to increase physical activity, yet relatively little is known about public opinion on utilizing transportation funds for such investments. This study sought to assess public awareness of and support for investments in walking and biking infrastructure in Los Angeles County. In the fall of 2013, the Los Angeles County Department of Public Health conducted a telephone survey with a random sample of registered voters in the region. The survey asked respondents to report on the presence and importance of walking and biking infrastructure in their community, travel behaviors and preferences, and demographics. One thousand and five interviews were completed (response rate 20%, cooperation rate 54%). The majority of participants reported walking, biking, and bus/rail transportation investments as being important. In addition, participants reported a high level of support for redirecting transportation funds to active transportation investment - the population average was 3.28 (between 'strongly' and 'somewhat' support) on a 4 point Likert scale. Voters see active transportation infrastructure as being very important and support redirecting funding to improve the infrastructure. These findings can inform policy-decisions and planning efforts in the jurisdiction. Copyright © 2015 Elsevier Inc. All rights reserved.

Advocacy Coalition for Safer Sex in the Adult Film Industry: The Case of Los Angeles County's Measure B.

Science.gov (United States)

Cohen, Adam Carl; Tavrow, Paula; McGrath, Mark Roy

2018-05-01

Performers in the adult film industry are routinely exposed to bloodborne pathogens. In 2012, public health advocates in Los Angeles County convinced voters to pass a ballot initiative-Measure B-to mandate condom use on adult film sets. This article presents a case study of the advocacy coalition's strategies used to achieve greater workplace safety using the advocacy coalition framework. The authors were given access to all memoranda, market research, and campaign tools used to promote Measure B. To reconstruct adult film industry counterefforts, the authors reviewed trade publications, social media, and blog posts. When legislative efforts failed, advocates engaged in a step-by-step strategy built around voters to achieve passage of a ballot initiative mandating condom use for all adult films produced in Los Angeles County. Although the industry immediately filed a lawsuit after passage of Measure B, its constitutionality has been upheld. Measure B passed because public health advocates were able to assemble scientific evidence, build public support, counter false claims, and maintain consistent messages throughout the campaign. The adult film industry lacked social capital, cohesion, and nimbleness. To bolster regulatory efforts, appealing to voters to favor safe workplaces may be an effective advocacy strategy for other industries.

Investigation of the Aerosols Over the Los Angeles Basin during the ARCTAS-CARB 2008 Pilot Study

Science.gov (United States)

Thornhill, L.; Anderson, B. E.; Beyersdorf, A.; Chen, G.; Winstead, E. L.; Lathem, T.; Diskin, G.; Sachse, G.; Dibb, J.; Scheuer, E.

2008-12-01

In the summer of 2008 during preparation for the second phase of the Arctic Research of the Composition of the Troposphere from Aircraft and Satellites (ARCTAS), detailed measurements of atmospheric composition were made on-board the NASA DC-8 over the state of California on behalf of the California Air resources Board (CARB). Four flights were conducted between 18 July and 24 July, totaling 31 hours, over southern and central California to establish upwind chemical boundary conditions and gain a better understanding of the sources, chemical characteristics and spatial distribution of smog and greenhouse gases over the state. Serendipitously, from a science perspective, this time period was marked by numerous wildfires spread throughout the state. The DC-8 sensor suite included aerosol instruments capable of measuring the number concentrations, optical properties, and size distributions of aerosols between 0.003 and 20 um in diameter. In this presentation, we will characterize aerosols sampled during sorties over the Los Angeles basin, which included several missed approaches at Los Angeles International Airport (LAX), traverses through the Long Beach and Santa Barbara ship channels, sampling in and out of the marine boundary layer, and encounters with outflow of forest fires mixed with urban smog. We will examine the evolution of the aerosols over the course of the day, as the smog accumulates within the basin and is then transported out of the basin into the surrounding atmosphere.

75 FR 35611 - Airworthiness Directives; McDonnell Douglas Corporation Model DC-10-10, DC-10-10F, and MD-10-10F...

Science.gov (United States)

2010-06-23

... Airworthiness Directives; McDonnell Douglas Corporation Model DC- 10-10, DC-10-10F, and MD-10-10F Airplanes... certain McDonnell Douglas Model DC-10-10, DC-10-10F, and MD-10-10F airplanes. That NPRM was published in... amends Sec. 39.13 by adding the following new AD: 2010-13-06 McDonnell Douglas Corporation: Amendment 39...

Evaluation of Resistance to Los Angeles Abrasion and Physical Factors with Grindability Properties of Some Aggregate Materials

Directory of Open Access Journals (Sweden)

C. Sensogut

2017-01-01

Full Text Available In recent years, the usage of aggregate materials has increased both in Turkey and the entire world. It can be said that the main reason of this rise is the population growth together with the demand towards the more qualitative life. Therefore, the usability of some aggregate materials was investigated in the present paper. The properties of Los Angeles abrasion resistance, freezing-thaw resistance, slake durability strength and frost resistance of basalt and andesite samples obtained from Karaman and Ankara regions were studied at the first stage. In the second order, the grindability performance of these materials was also determined from the discontinuous grinding tests and the obtained results were correlated. Whereas the Los Angeles resistance of the basalt sample was higher than the andesite sample, the mass losses after the freezing-thaw and the frost tests for the andesite sample were superior. Both of the basalt and andesite samples were classified as ‘very high’ for their slake durability strength (Id-2 values. The material percentage of the andesite sample, which is passing through the sub-size ( %90 was greater than the value obtained for the basalt sample during the same grinding time. The resistance to the crushing process was obtained to be maximum at -850+600 µm of feed size for the basalt and the andesite samples.

MD simulation: determination of the physical properties and surface vaporization analysis of beryllium armours

International Nuclear Information System (INIS)

Prinzio, M. Di; Aquaro, D.

2006-01-01

The erosion of the divertor and of the first wall determined on the base of the anticipated operating conditions, is a critical issue that could affect the performance and the operating schedule of the nuclear fusion reactor ITER. This paper deals with the analysis of beryllium thermal properties by means of MD simulations, in order to better predict thermal behaviour of beryllium armoured PFCs in fusion devices. The importance of this analysis is clearly connected to thermal response evaluation of PFCs to high heat flux exposure, during off-normal events and Edge Localized Modes. The ensuing strong over-heating, in fact, produces material ablation through vaporization of surface material layers and possible loss of melting material. The overall PFCs erosion has bearings on plasma contamination, due to eroded material transport, and components lifetime, due to armour thickness reduction. An important feature of beryllium is its high vapour pressure. During thermal transients the strong vaporization keeps surface temperature relatively low but eroded thickness results high as well. Small changes in beryllium vapour pressure produce not negligible differences in thermal analyses results. On the basis of available force fields, classical Molecular Dynamics simulations have been carried out in order to better understand surface vaporization in tokamak conditions and to evaluate the effect of beryllium oxides formation. This effect has been successfully modelled by MD simulation, carried out with Moldy code. Morse stretching and bending potential for Be-O bond simulation have been used, and partial charges method, accounting for molecular polarity, has been employed. Since during short thermal transients, such as ELMs, only a few microns of Be armour will be overheated and reach melting threshold, the effective thermal conductivity is very important in determining the temperature evolution of surface layers and the ensuing erosion. Thermal conductivity can be evaluated

75 FR 66653 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

Science.gov (United States)

2010-10-29

... Airworthiness Directives; McDonnell Douglas Corporation Model MD- 90-30 Airplanes AGENCY: Federal Aviation...-15667 (73 FR 52203, September 9, 2008), and adding the following new AD: 2010-22-04 McDonnell Douglas... supersedes AD 2008-18-10, Amendment 39-15667. Applicability (c) This AD applies to McDonnell Douglas...

CicLAvia: Evaluation of participation, physical activity and cost of an open streets event in Los Angeles

OpenAIRE

Cohen, Deborah; Han, Bing; Derose, Kathryn P.; Williamson, Stephanie; Paley, Aaron; Batteate, Christina

2016-01-01

Physical activity is beneficial for health, but there are limited opportunities in urban areas to safely access public streets for traffic-free cycling, skating or walking. Ciclovías are open streets programs that close major roads to motor vehicles so they can be exclusively used by bicyclists and pedestrians. We estimated participation in one Los Angeles Ciclovía event (CicLAvia) using intercept surveys and 14 surveillance cameras which were placed along the 6-mile route in April, 2014. We ...

Combined Mobile In Situ and Remote Sensing Investigation of the Aliso Canyon Natural Gas Leak in the Los Angeles Basin, California

Science.gov (United States)

Hall, J. L.; Leifer, I.; Tratt, D. M.; Melton, C.; Frash, J.

2016-12-01

The Aliso Canyon natural gas leak in the San Fernando Valley in Los Angeles, California was a major disruptive event whose societal impacts have continued well after the event itself ended, yet fortunately did not involve highly toxic gases. Chemical releases can have serious consequences for ecosystems, societies, and human health. Mitigating their destructive impacts relies on identification and mapping, monitoring, and trajectory forecasting. Improvements in the accuracy of such transport modeling capabilities can significantly improve the effectiveness of disaster response activities. Simultaneous plume characterization data were collected by the Mobile Infrared Sensor for Tactical Incident Response (MISTIR) and AutoMObile trace Gas (AMOG) Surveyor, two instrumented vehicles traveling in convoy. Surface vehicles have advantages over airplanes in terms of simpler logistics, such as not being limited by controlled airspace which is a major issue in Los Angeles, and ability to deploy rapidly. Moreover, it is the surface concentration that impacts human health and determines ecological damage. Fusion of the resulting correlative surface in situ observations and thermal-infrared spectroscopic column observations allowed both lateral and temporal plume characterization to derive emissions and to characterize the confining effect of topography on plume dispersion. Although a straightforward Gaussian plume inversion approach based on surface data yields an emission estimate with reasonable fidelity, it required assumptions of vertical profile and topographic influence that were validated by the column spectroscopic observations. Topographic factors within the Los Angeles Basin, including the Aliso Canyon locale, strongly influence transport processes. This situation challenges the predictive skill of numerical transport models that are used to assist the evacuation of at-risk communities, for example in the case of a refinery fire. This study demonstrated the utility

Development and Flight Test of an Augmented Thrust-Only Flight Control System on an MD-11 Transport Airplane

Science.gov (United States)

Burcham, Frank W., Jr.; Maine, Trindel A.; Burken, John J.; Pappas, Drew

1996-01-01

An emergency flight control system using only engine thrust, called Propulsion-Controlled Aircraft (PCA), has been developed and flight tested on an MD-11 airplane. In this thrust-only control system, pilot flight path and track commands and aircraft feedback parameters are used to control the throttles. The PCA system was installed on the MD-11 airplane using software modifications to existing computers. Flight test results show that the PCA system can be used to fly to an airport and safely land a transport airplane with an inoperative flight control system. In up-and-away operation, the PCA system served as an acceptable autopilot capable of extended flight over a range of speeds and altitudes. The PCA approaches, go-arounds, and three landings without the use of any non-nal flight controls have been demonstrated, including instrument landing system-coupled hands-off landings. The PCA operation was used to recover from an upset condition. In addition, PCA was tested at altitude with all three hydraulic systems turned off. This paper reviews the principles of throttles-only flight control; describes the MD-11 airplane and systems; and discusses PCA system development, operation, flight testing, and pilot comments.

Luminosity Anti-leveling with Crossing Angle (MD 1669)

CERN Document Server

Gorzawski, Arkadiusz; Ponce, Laurette; Salvachua Ferrando, Belen Maria; Wenninger, Jorg; CERN. Geneva. ATS Department

2016-01-01

A significant fraction of the LHC luminosity ($\\sim$30\\% in 2016) is lost due to the presence (and necessity) of the crossing angles at the IPs. At the LHC the crossing angle is typically set to a value that provides sufficient separation of the beams at the start of fills for the peak bunch intensities. As the bunch intensity decays during a fill, it is possible to reduce the crossing angle and recover some luminosity. A smooth crossing angle reduction procedure must be developed to take advantage of this option during stable beam operation. During this MD a smooth procedure for luminosity leveling with crossing angle was tested. It was demonstrated that the orbit was well controlled, beam losses were low and the offset leveled experiments ALICE and LHCb were not affected by crossing angle leveling in ATLAS and CMS.

Phenology of the adult angel lichen moth (Cisthene angelus) in Grand Canyon, USA

Science.gov (United States)

Metcalfe, Anya; Kennedy, Theodore A.; Muehlbauer, Jeffrey D.

2016-01-01

We investigated the phenology of adult angel lichen moths (Cisthene angelus) along a 364-km long segment of the Colorado River in Grand Canyon, Arizona, USA, using a unique data set of 2,437 light-trap samples collected by citizen scientists. We found that adults of C. angelus were bivoltine from 2012 to 2014. We quantified plasticity in wing lengths and sex ratios among the two generations and across a 545-m elevation gradient. We found that abundance, but not wing length, increased at lower elevations and that the two generations differed in size and sex distributions. Our results shed light on the life history and morphology of a common, but poorly known, species of moth endemic to the southwestern United States and Mexico.

Multidimensional Recurrence Quantification Analysis (MdRQA) for the Analysis of Multidimensional Time-Series: A Software Implementation in MATLAB and Its Application to Group-Level Data in Joint Action.

Science.gov (United States)

Wallot, Sebastian; Roepstorff, Andreas; Mønster, Dan

2016-01-01

We introduce Multidimensional Recurrence Quantification Analysis (MdRQA) as a tool to analyze multidimensional time-series data. We show how MdRQA can be used to capture the dynamics of high-dimensional signals, and how MdRQA can be used to assess coupling between two or more variables. In particular, we describe applications of the method in research on joint and collective action, as it provides a coherent analysis framework to systematically investigate dynamics at different group levels-from individual dynamics, to dyadic dynamics, up to global group-level of arbitrary size. The Appendix in Supplementary Material contains a software implementation in MATLAB to calculate MdRQA measures.

75 FR 38056 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

Science.gov (United States)

2010-07-01

...-0645; Directorate Identifier 2009-NM-200-AD] RIN 2120-AA64 Airworthiness Directives; McDonnell Douglas..., September 9, 2008), for certain McDonnell Douglas Corporation Model MD-90-30 airplanes. That AD requires a... fasteners in the aft mount support fitting of the left and right engines on 29 McDonnell Douglas Corporation...

MD2723 - Amplitude Detuning Studies at 6.5 TeV with Various Configurations of the Crossing Scheme

CERN Document Server

Carlier, Felix Simon; Dilly, Joschua Werner; Fol, Elena; Garcia-Tabares Valdivieso, Ana; Maclean, Ewen Hamish; Malina, Lukas; Persson, Tobias Hakan Bjorn; Skowronski, Piotr Krzysztof; Tomas Garcia, Rogelio; CERN. Geneva. ATS Department

2018-01-01

Particular interst exists to better understand the amplitude detuning through the LHC cycle in order to shed some light on possible sources of instabilities, and better prepair for the β* squeeze to 25cm in 2018. This note reports on the amplitude etuning measurements taken on the 3rd of December of 2017 during MD2723. Amplitude detuning measurements are presented at flattop with crossing angles and at end-of-squeeze with and without crossing angles. Furthermore tests of the skew octupolar corrections in IP5 done at the end of the MD are presented, with specific focus on forced DA and resonance driving terms measurements.

Hybrid Pressure Retarded Osmosis−Membrane Distillation (PRO−MD) Process for Osmotic Power and Clean Water Generation

KAUST Repository

Han, Gang; Zuo, Jian; Wan, Chunfeng; Chung, Neal Tai-Shung

2015-01-01

unique advantages of high water recovery rate, huge osmotic power generation, well controlled membrane fouling, and minimal environmental impacts. Experimental results show that the PRO−MD hybrid process is promising that not only can harvest osmotic

Anxiety disorders among Mexican Americans and non-Hispanic whites in Los Angeles.

Science.gov (United States)

Karno, M; Golding, J M; Burnam, M A; Hough, R L; Escobar, J I; Wells, K M; Boyer, R

1989-04-01

This report from the Los Angeles site of the NIMH Epidemiologic Catchment Area study reveals significant ethnic and national origin differences in lifetime prevalence rates for three out of six specific, DSM-III-defined anxiety disorders. In the case of simple phobia, United States-born Mexican Americans report higher rates than native non-Hispanic whites or immigrant Mexican Americans, the latter two groups having similar rates. Mexican Americans born in the United States had higher rates of agoraphobia than immigrant Mexican Americans, and non-Hispanic whites reported higher lifetime rates of generalized anxiety disorder compared with both immigrant and native Mexican Americans. Neither ethnic nor national origin differences in lifetime prevalence rates were found for panic disorder, social phobia, and obsessive-compulsive disorder. Selective migration is postulated as a potential factor influencing prevalence differences between native and immigrant Mexican Americans.

Cyber against punk: Greg Bear’s Queen of Angels as metamorphosed cyberpunk

Directory of Open Access Journals (Sweden)

M. F. Blatchford

1994-05-01

Full Text Available Recent American science fiction (which commercially dominates world science fiction incorporates two schools of thought, ‘cyberpunk' and ‘hard SF’. which may be read to embody, respectively, radical/liberal and patriotic/ conservative propaganda. This article, after attempting to define aspects of these schools, examines Queen of Angels by Greg Bear (who before producing that text had been a proponent of hard SF. This text is shown to have strong elements of cyberpunk (possibly, to judge by one critical review, appealing to a cyberpunk audience but to have transformed and inverted the radical and liberal themes of cyberpunk into conservative themes. The text thus illuminates philosophical and technical differences between the schools. It is suggested that the imagery of cyberpunk, and perhaps that of science fiction in general, is liable to such reversals of ideological significance.

Characterization of Bitumen Micro-Mechanical Behaviors Using AFM, Phase Dynamics Theory and MD Simulation

Directory of Open Access Journals (Sweden)

Yue Hou

2017-02-01

Full Text Available Fundamental understanding of micro-mechanical behaviors in bitumen, including phase separation, micro-friction, micro-abrasion, etc., can help the pavement engineers better understand the bitumen mechanical performances at macroscale. Recent researches show that the microstructure evolution in bitumen will directly affect its surface structure and micro-mechanical performance. In this study, the bitumen microstructure and micro-mechanical behaviors are studied using Atomic Force Microscopy (AFM experiments, Phase Dynamics Theory and Molecular Dynamics (MD Simulation. The AFM experiment results show that different phase-structure will occur at the surface of the bitumen samples under certain thermodynamic conditions at microscale. The phenomenon can be explained using the phase dynamics theory, where the effects of stability parameter and temperature on bitumen microstructure and micro-mechanical behavior are studied combined with MD Simulation. Simulation results show that the saturates phase, in contrast to the naphthene aromatics phase, plays a major role in bitumen micro-mechanical behavior. A high stress zone occurs at the interface between the saturates phase and the naphthene aromatics phase, which may form discontinuities that further affect the bitumen frictional performance.

Characterization of Bitumen Micro-Mechanical Behaviors Using AFM, Phase Dynamics Theory and MD Simulation.

Science.gov (United States)

Hou, Yue; Wang, Linbing; Wang, Dawei; Guo, Meng; Liu, Pengfei; Yu, Jianxin

2017-02-21

Fundamental understanding of micro-mechanical behaviors in bitumen, including phase separation, micro-friction, micro-abrasion, etc., can help the pavement engineers better understand the bitumen mechanical performances at macroscale. Recent researches show that the microstructure evolution in bitumen will directly affect its surface structure and micro-mechanical performance. In this study, the bitumen microstructure and micro-mechanical behaviors are studied using Atomic Force Microscopy (AFM) experiments, Phase Dynamics Theory and Molecular Dynamics (MD) Simulation. The AFM experiment results show that different phase-structure will occur at the surface of the bitumen samples under certain thermodynamic conditions at microscale. The phenomenon can be explained using the phase dynamics theory, where the effects of stability parameter and temperature on bitumen microstructure and micro-mechanical behavior are studied combined with MD Simulation. Simulation results show that the saturates phase, in contrast to the naphthene aromatics phase, plays a major role in bitumen micro-mechanical behavior. A high stress zone occurs at the interface between the saturates phase and the naphthene aromatics phase, which may form discontinuities that further affect the bitumen frictional performance.

Elevated levels of radioactivity in water wells in Los Angeles and Orange Counties, California

International Nuclear Information System (INIS)

Weigand, J.; Yamamoto, G.; Gaston, W.

1987-01-01

Levels of gross alpha particle radioactivity nearly three times the maximum contamination levels (MCL) have been detected for several years in well waters and related surface waters in Los Angeles and Orange Counties, California. A few elevated levels of uranium have also been recorded. The affected wells and related surface waters represent only a minor fraction of the water sampled and tested in this area. None of the excessive radioactivity is believed to persist in the municipal waters sold to the public, due to the customary blending of waters from several wells or sources which water purveyors practice. This papers is a preliminary survey of the occurrence, possible sources, fate, and implications of these elevated radioactivity levels

78 FR 17996 - MCM Rail Services LLC-Petition for Retroactive Exemption-In Sparrows Point, Md.

Science.gov (United States)

2013-03-25

... DEPARTMENT OF TRANSPORTATION Surface Transportation Board [Docket No. FD 35707] MCM Rail Services... regarding a petition for an operation exemption submitted by MCM Rail Services LLC (MCM) regarding 12 miles of rail line in Sparrows Point, Md. (the Line). DATES: MCM's supplemental information is due by April...

Security concept in 'MyAngelWeb((R))' a website for the individual patient at risk of emergency.

Science.gov (United States)

Pinciroli; Nahaissi; Boschini; Ferrari; Meloni; Camnasio; Spaggiari; Carnerone

2000-11-01

We describe the Security Plan for the 'MyAngelWeb' service. The different actors involved in the service are subject to different security procedures. The core of the security system is implemented at the host site by means of a DBMS and standard Information Technology tools. Hardware requirements for sustainable security are needed at the web-site construction sites. They are not needed at the emergency physician's site. At the emergency physician's site, a two-way authentication system (password and test phrase method) is implemented.

Orbit Feedback Operation with RCBX (MD 1209)

CERN Document Server

Wenninger, Jorg; Nisbet, David; Ponce, Laurette; Louro Alves, Diogo Miguel; CERN. Geneva. ATS Department

2017-01-01

The LHC Orbit Feedback (OFB) is able to drive any orbit corrector circuit (COD) to steer the LHC orbit. But during the first feedback tests in 2010, all attempts to use the common triplet orbit correctors (MCBX) failed because the QPS system installed to protect those magnets triggered power aborts as soon as the OFB steered the beam with those CODs. The reason was most likely the violation of the RCBX circuit acceleration limits. For this reason the MCBX orbit correctors were never driven by the OFB in regular operation. Although the performance of the OFB is generally excellent, the quality of the beam steering around IRs could be improved if the OFB could correct the orbit with the MCBX to counteract locally triplet quadrupole movements. The aim of this MD was to make a new attempt to use the MCBX in the OFB. The test was successful at injection (no circuit trip) and failed during the ramp (QPS power abort). The PC voltages and QPS Ures signals revealed the presence of voltage spikes with a period of 10~s...

Restaurant owners' perspectives on a voluntary program to recognize restaurants for offering reduced-size portions, Los Angeles County, 2012.

Science.gov (United States)

Gase, Lauren; Dunning, Lauren; Kuo, Tony; Simon, Paul; Fielding, Jonathan E

2014-03-20

Reducing the portion size of food and beverages served at restaurants has emerged as a strategy for addressing the obesity epidemic; however, barriers and facilitators to achieving this goal are not well characterized. In fall 2012, the Los Angeles County Department of Public Health conducted semistructured interviews with restaurant owners to better understand contextual factors that may impede or facilitate participation in a voluntary program to recognize restaurants for offering reduced-size portions. Interviews were completed with 18 restaurant owners (representing nearly 350 restaurants). Analyses of qualitative data revealed 6 themes related to portion size: 1) perceived customer demand is central to menu planning; 2) multiple portion sizes are already being offered for at least some food items; 3) numerous logistical barriers exist for offering reduced-size portions; 4) restaurant owners have concerns about potential revenue losses from offering reduced-size portions; 5) healthful eating is the responsibility of the customer; and 6) a few owners want to be socially responsible industry leaders. A program to recognize restaurants for offering reduced-size portions may be a feasible approach in Los Angeles County. These findings may have applications for jurisdictions interested in engaging restaurants as partners in reducing the obesity epidemic.

Restaurant Owners’ Perspectives on a Voluntary Program to Recognize Restaurants for Offering Reduced-Size Portions, Los Angeles County, 2012

Science.gov (United States)

Dunning, Lauren; Kuo, Tony; Simon, Paul; Fielding, Jonathan E.

2014-01-01

Introduction Reducing the portion size of food and beverages served at restaurants has emerged as a strategy for addressing the obesity epidemic; however, barriers and facilitators to achieving this goal are not well characterized. Methods In fall 2012, the Los Angeles County Department of Public Health conducted semistructured interviews with restaurant owners to better understand contextual factors that may impede or facilitate participation in a voluntary program to recognize restaurants for offering reduced-size portions. Results Interviews were completed with 18 restaurant owners (representing nearly 350 restaurants). Analyses of qualitative data revealed 6 themes related to portion size: 1) perceived customer demand is central to menu planning; 2) multiple portion sizes are already being offered for at least some food items; 3) numerous logistical barriers exist for offering reduced-size portions; 4) restaurant owners have concerns about potential revenue losses from offering reduced-size portions; 5) healthful eating is the responsibility of the customer; and 6) a few owners want to be socially responsible industry leaders. Conclusion A program to recognize restaurants for offering reduced-size portions may be a feasible approach in Los Angeles County. These findings may have applications for jurisdictions interested in engaging restaurants as partners in reducing the obesity epidemic. PMID:24650622

West Angeles Community Development Corporation final technical report on export market feasibility planning and research for the solar medical autoclave

Energy Technology Data Exchange (ETDEWEB)

Power, G.D.

1998-04-20

This report summarizes core findings from an investigation performed by the staff of West Angeles Community Development Corporation (CDC) regarding the feasibility of marketing the Solar Medical Autoclave (``autoclave``) in South Africa. The investigation was completed during 1997, the period prescribed by the Grant Award made by the U.S. Department of Energy on January 1, 1997, and was monitored by the National Renewable Energy Laboratory.

The Pasadena Aerosol Characterization Observatory (PACO: chemical and physical analysis of the Western Los Angeles basin aerosol

Directory of Open Access Journals (Sweden)

S. P. Hersey

2011-08-01

Full Text Available The Pasadena Aerosol Characterization Observatory (PACO represents the first major aerosol characterization experiment centered in the Western/Central Los Angeles Basin. The sampling site, located on the campus of the California Institute of Technology in Pasadena, was positioned to sample a continuous afternoon influx of transported urban aerosol with a photochemical age of 1–2 h and generally free from major local contributions. Sampling spanned 5 months during the summer of 2009, which were broken into 3 regimes on the basis of distinct meteorological conditions. Regime I was characterized by a series of low pressure systems, resulting in high humidity and rainy periods with clean conditions. Regime II typified early summer meteorology, with significant morning marine layers and warm, sunny afternoons. Regime III was characterized by hot, dry conditions with little marine layer influence. Regardless of regime, organic aerosol (OA is the most significant constituent of nonrefractory submicron Los Angeles aerosol (42, 43, and 55 % of total submicron mass in regimes I, II, and III, respectively. The overall oxidation state remains relatively constant on timescales of days to weeks (O:C = 0.44 ± 0.08, 0.55 ± 0.05, and 0.48 ± 0.08 during regimes I, II, and III, respectively, with no difference in O:C between morning and afternoon periods. Periods characterized by significant morning marine layer influence followed by photochemically favorable afternoons displayed significantly higher aerosol mass and O:C ratio, suggesting that aqueous processes may be important in the generation of secondary aerosol and oxidized organic aerosol (OOA in Los Angeles. Online analysis of water soluble organic carbon (WSOC indicates that water soluble organic mass (WSOM reaches maxima near 14:00–15:00 local time (LT, but the percentage of AMS organic mass contributed by WSOM remains relatively constant throughout the day. Sulfate and nitrate reside predominantly

THE ISOLATION AND IDENTIFICATION OF MYCOBACTERIUM AVIUM COMPLEX (MAC) RECOVERED FROM LOS ANGELES POTABLE WATER, A POSSIBLE SOURCE OF INFECTION IN AIDS PATIENTS

Science.gov (United States)

Los Angeles water was investigated as a possible source of Mycobacterium avium complex (MAC) infection in patients with AIDS. MAC consists of M.avium (MA), M. intracellulare (MI) and Mycobacterium X (MX)(positive for MAC by DNA probe but not MA or MI). The study included 13 reser...

The Tragedy of a Patriarchal Angel: On Lady Macbeth’s Submission to Patriarchy in Macbeth

Institute of Scientific and Technical Information of China (English)

黄琳

2015-01-01

William Shakespeare(1564-1616),as Ben Jonson assured us,is "not of an age but for all time".Macbeth,one of William Shakespeare’s most important plays,is much favored by critics for its representation of the female character Lady Macbeth who is usually regarded as the "fiend-like Queen" or a super witch by Goethe.Nevertheless,other critics like Christina Leon Alfar asserted in her article "Blood will have blood: Power,Performance,and the Trouble with Gender" believe that Lady Macbeth represented gender stereotyping.Therefore,in this essay,she is represented as a perfect wife,"The Angel in the House",and the "Other" in men’s world______________。

Food for Thought: Recommendations to Improve the Relationship between the City of Los Angeles and its Food Processing Sector

OpenAIRE

Marian Fowler; Rachel Freitas; Jessica Nierenberg; Diana Simpson

2004-01-01

Since the 1980s, the manufacturing sector has been steadily declining in Los Angeles, weakening the fabric of the community, diminishing the tax base, decreasing the amount of revenue available for social services, and reducing property values. To address these problems, the City is targeting industry clusters that are growing and for which the City provides a competitive advantage. The Food Processing industry, composed of manufacturers, producers, and packagers of food and beverages fo...

Of how the Father of Heaven, the Easter bunny, Santa and the angels were living together in the sky!

Directory of Open Access Journals (Sweden)

Ana Beatriz Cerisara

2002-01-01

Full Text Available This text refers to the following question: After all, where was that the children took the idea that the Father of Heaven, the Easter Rabbit, the angels and Santa Claus live together in heaven? This may be appropriate to assist us in thinking about how the subject - in particular the children - is a given culture and the relationship between the imagined and the real world activity in human conduct.

Case-control study of intracranial meningiomas in women in Los Angeles County, California

International Nuclear Information System (INIS)

Preston-Martin, S.; Paganini-Hill, A.; Henderson, B.E.; Pike, M.C.; Wood, C.

1980-01-01

A case-control study was conducted among women in Los Angeles County to investigate possible causes of intracranial meningiomas. Questionnaires sought information from patients and from a neighbor of each one on characteristics and past experiences that might be associated with the development of this disease. Information was obtained on 188 matched patient-neighbor pairs. Three primary factors appeared to be associated with meningioma occurrence: 1) a history of head trauma (odds ratio = 2.0, p = 0.01), 2) consumption of certain cured meats (odds ratio = 2.8, p = less than 0.01), and 3) exposure to medical and dental diagnostic X-rays to the head. For diagnostic X-rays, the strongest association was with early exposure (less than 20 yr old) to full-mouth dental X-ray series

Overexpression of a Novel Apple NAC Transcription Factor Gene, MdNAC1, Confers the Dwarf Phenotype in Transgenic Apple (Malus domestica)

Science.gov (United States)

Jia, Dongfeng; Gong, Xiaoqing; Li, Mingjun; Li, Chao; Sun, Tingting

2018-01-01

Plant height is an important trait for fruit trees. The dwarf characteristic is commonly associated with highly efficient fruit production, a major objective when breeding for apple (Malus domestica). We studied the function of MdNAC1, a novel NAC transcription factor (TF) gene in apple related to plant dwarfing. Localized primarily to the nucleus, MdNAC1 has transcriptional activity in yeast cells. Overexpression of the gene results in a dwarf phenotype in transgenic apple plants. Their reduction in size is manifested by shorter, thinner stems and roots, and a smaller leaf area. The transgenics also have shorter internodes and fewer cells in the stems. Levels of endogenous abscisic acid (ABA) and brassinosteroid (BR) are lower in the transgenic plants, and expression is decreased for genes involved in the biosynthesis of those phytohormones. All of these findings demonstrate that MdNAC1 has a role in plants dwarfism, probably by regulating ABA and BR production. PMID:29702625

Development of urban water consumption models for the City of Los Angeles

Science.gov (United States)

Mini, C.; Hogue, T. S.; Pincetl, S.

2011-12-01

Population growth and rapid urbanization coupled with uncertain climate change are causing new challenges for meeting urban water needs. In arid and semi-arid regions, increasing drought periods and decreasing precipitation have led to water supply shortages and cities are struggling with trade-offs between the water needs of growing urban populations and the well-being of urban ecosystems. The goal of the current research is to build models that can represent urban water use patterns in semi-arid cities by identifying the determinants that control both total and outdoor residential water use over the Los Angeles urban domain. The initial database contains monthly water use records aggregated to the zip code level collected from the Los Angeles Department of Water and Power (LADWP) from 2000 to 2010. Residential water use was normalized per capita and was correlated with socio-demographic, economic, climatic and vegetation characteristics across the City for the 2000-2010 period. Results show that ethnicity, per capita income, and the average number of persons per household are linearly related to total water use per capita. Inter-annual differences in precipitation and implementation of conservation measures affect water use levels across the City. The high variability in water use patterns across the City also appears strongly influenced by income and education levels. The temporal analysis of vegetation indices in the studied neighborhoods shows little correlation between precipitation patterns and vegetation greenness. Urban vegetation appears well-watered, presenting the same greenness activity over the study period despite an overall decrease in water use across the City. We hypothesize that over-watering is occurring and that outdoor water use represents a significant part of the residential water budget in various regions of the City. A multiple regression model has been developed that integrates these fundamental controlling factors to simulate residential

MD456: Monitoring of abort gap population with diamond particle detectors at the BGI in IP 4

CERN Document Server

Stein, Oliver

2016-01-01

In this MD, diamond based particle detectors (dBLM) were used for measuring showers of the beam interactions with the in the BGI induced neon gas. This setup was proposed in a feasibility study for using dBLMs at the BGI to measure the abort gap population by detecting the beam gas interactions. During the MD neon gas was induced in the BGI vacuum chamber to increase the interaction rate. Two nominal bunches were injected and accelerated up to 6.5 TeV. The measurements lasted for 140 minutes. The bunches could be clearly identified. But the resulting count rate of the beam gas interactions was a factor 70 lower than predicted by the feasibility study. In addition, a problem with the timing information lead to a widening of the histogram peaks.

Dissecting the Science of 'Angels and Demons' or Antimatter and Other Matters (Vernon W. Hughes Memorial Lecture)

International Nuclear Information System (INIS)

Gordon, Howard

2009-01-01

Howard Gordon, a physicist from the U.S. Department of Energy's Brookhaven National Laboratory, and local educators will separate the science facts from the science fiction of 'Angels and Demons,' a major motion picture based on Dan Brown's best-selling novel. The film, which opens nationally in theaters today, focuses on a plot to destroy the Vatican using antimatter stolen from the Large Hadron Collider (LHC) at the European particle physics laboratory CERN. Speakers will explain the real science of the LHC, including antimatter - oppositely charged cousins of ordinary matter with intriguing properties.

78 FR 11142 - Connor Hayden Kraegel, 19917 Spurrier Avenue, Poolesville, MD 20837; Order Denying Export Privileges

Science.gov (United States)

2013-02-15

... DEPARTMENT OF COMMERCE Bureau of Industry and Security Connor Hayden Kraegel, 19917 Spurrier... Court, District of Maryland, Connor Hayden Kraegel (``Kraegel'') was convicted of violating Section 38... Hayden Kraegel, with a last known address at: 19917 Spurrier Avenue, Poolesville, MD 20837, and when...

The visibility of The lettered city Angel Rama in mainstream literature (WOS

Directory of Open Access Journals (Sweden)

Exequiel Aarón Fontans Alvarez

2015-11-01

Full Text Available Angel Rama (1926-1986 is noted by some specialized as one of the precursors of the current cultural studies in Latin authors; The lettered city is one of the most cited works and has written stating this influence. However it has not been approached from the Metric Information Studies. The aim of this paper is to highlight the visibility of the lettered city in mainstream literature collected by the Web based of Science (WOS, Thomson Reuters. A brief introduction to the British Cultural Studies (Birmingham School is performed, with the understanding that they represent a history of Latin American Cultural Studies, where this work is framed. Areas, institutions and sources where this work is cited and co-cited authors are presented. Finally low visibility reflected WOS noted in the Latin American production considering that "lettered city" is a theoretical concept coined in the region.

The attenuated inflammation of MPL is due to the lack of CD14-dependent tight dimerization of the TLR4/MD2 complex at the plasma membrane.

Science.gov (United States)

Tanimura, Natsuko; Saitoh, Shin-Ichiroh; Ohto, Umeharu; Akashi-Takamura, Sachiko; Fujimoto, Yukari; Fukase, Koichi; Shimizu, Toshiyuki; Miyake, Kensuke

2014-06-01

TLR4/MD-2 senses lipid A, activating the MyD88-signaling pathway on the plasma membrane and the TRIF-signaling pathway after CD14-mediated TLR4/MD-2 internalization into endosomes. Monophosphoryl lipid A (MPL), a detoxified derivative of lipid A, is weaker than lipid A in activating the MyD88-dependent pathway. Little is known, however, about mechanisms underlying the attenuated activation of MyD88-dependent pathways. We here show that MPL was impaired in induction of CD14-dependent TLR4/MD-2 dimerization compared with lipid A. Impaired TLR4/MD-2 dimerization decreased CD14-mediated TNFα production. In contrast, MPL was comparable to lipid A in CD14-independent MyD88-dependent TNFα production and TRIF-dependent responses including cell surface CD86 up-regulation and IFNβ induction. Although CD86 up-regulation is dependent on TRIF signaling, it was induced by TLR4/MD-2 at the plasma membrane. These results revealed that the attenuated MPL responses were due to CD14-initiated responses at the plasma membrane, but not just to responses initiated by MyD88, that is, MPL was specifically unable to induce CD14-dependent TLR4/MD-2 dimerization that selectively enhances MyD88-mediated responses at the plasma membrane. © The Japanese Society for Immunology. 2013. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Prediction of Osmotic Pressure of Ionic Liquids Inside a Nanoslit by MD Simulation and Continuum Approach

Science.gov (United States)

Moon, Gi Jong; Yang, Yu Dong; Oh, Jung Min; Kang, In Seok

2017-11-01

Osmotic pressure plays an important role in the processes of charging and discharging of lithium batteries. In this work, osmotic pressure of the ionic liquids confined inside a nanoslit is calculated by using both MD simulation and continuum approach. In the case of MD simulation, an ionic liquid is modeled as singly charged spheres with a short-ranged repulsive Lennard-Jones potential. The radii of the spheres are 0.5nm, reflecting the symmetry of ion sizes for simplicity. The simulation box size is 11nm×11nm×7.5nm with 1050 ion pairs. The concentration of ionic liquid is about 1.922mol/L, and the total charge on an individual wall varies from +/-60e(7.944 μm/cm2) to +/-600e(79.44 μm/cm2) . In the case of continuum approach, we classify the problems according to the correlation length and steric factor, and considered the four separate cases: 1) zero correlation length and zero steric factor, 2) zero correlation length and non-zero steric factor, 3) non-zero correlation length and zero steric factor, and 4) non-zero correlation and non-zero steric factor. Better understanding of the osmotic pressure of ionic liquids confined inside a nanoslit can be achieved by comparing the results of MD simulation and continuum approach. This research was supported by the National Research Foundation of Korea (NRF) Grant funded by the Korea government (MSIP: Ministry of Science, ICT & Future Planning) (No. 2017R1D1A1B05035211).

75 FR 18778 - Safety Zone; Ocean City Air Show 2010, Atlantic Ocean, Ocean City, MD

Science.gov (United States)

2010-04-13

...-AA00 Safety Zone; Ocean City Air Show 2010, Atlantic Ocean, Ocean City, MD AGENCY: Coast Guard, DHS... zone on the Atlantic Ocean in the vicinity of Ocean City, Maryland to support the Ocean City Air Show. This action is intended to restrict vessel traffic movement on the Atlantic Ocean to protect mariners...

"Weak-Center" Gentrification and the Contradictions of Containment: deconcentrating poverty in downtown Los Angeles.

Science.gov (United States)

Reese, Ellen; DeVerteuil, Geoffrey; Thach, Leanne

2010-01-01

This case study of recent efforts to deconcentrate poverty within the Skid Row area of Los Angeles examines processes of "weak-center" gentrification as it applies to a "service dependent ghetto," thus filling two key gaps in prior scholarship. We document the collaboration between the government, business and development interests, and certain non-profit agencies in this process and identify two key mechanisms of poverty deconcentration: housing/service displacement and the criminalization of low income residents. Following Harvey, we argue that these efforts are driven by pressures to find a "spatial fix" for capital accumulation through Downtown redevelopment. This process has been hotly contested, however, illustrating the strength of counter-pressures to gentrification/poverty deconcentration within "weak-center" urban areas.

Legal Status, Time in the USA, and the Well-Being of Latinos in Los Angeles.

Science.gov (United States)

Young, Maria-Elena De Trinidad; Pebley, Anne R

2017-12-01

In the USA, undocumented Latino immigrants may have poorer health because of barriers to health care, stressors, and detrimental effects of immigration enforcement. Previous immigrant health research, however, suggests that recently arrived Latino immigrants have better health than US-born Latinos and their health deteriorates over time. Given the current environments that undocumented immigrants face, legal status is a structural factor that likely influences the patterns of immigrant health. Therefore, the aim of this study was to examine the extent to which physical and mental health differed by legal status and duration in the USA for the Latino population in Los Angeles County, California. We conducted analysis of Latino respondents (n = 1396) to the Los Angeles Family and Neighborhood Survey (L.A.FANS) Wave II. We examined self-reported health, depression measured by the Composite International Diagnostic Interview-Short Form, and blood pressure collected by trained interviewers. Respondents reported their legal status, time in the USA, and other sociodemographic characteristics. Regression models were used to test associations between each outcome and 1) legal status and 2) legal status by duration (≤ 15 and > 15 years) in the USA. Without taking duration into account, we found no significant differences in outcomes between undocumented, documented, or US-born Latinos. Taking duration into account, shorter duration undocumented immigrants had worse self-reported health than the US born. Undocumented immigrants, regardless of duration, had higher blood pressure than documented immigrants who had been in the USA for less time and the same level of blood pressure as the US born. In contrast, shorter duration documented immigrants had lower blood pressure compared to longer duration documented immigrants and US-born counterparts, and marginally lower blood pressure than shorter duration undocumented immigrants. The findings suggest that the "health

Cost of near-roadway and regional air pollution-attributable childhood asthma in Los Angeles County

Science.gov (United States)

Brandt, Sylvia; Perez, Laura; Künzli, Nino; Lurmann, Fred; Wilson, John; Pastor, Manuel; McConnell, Rob

2014-01-01

Background Emerging evidence suggests that near-roadway air pollution (NRP) exposure causes childhood asthma. Associated costs are not well documented. Objective We estimated the cost of childhood asthma attributable to residential NRP exposure and regional ozone (O3) and nitrogen dioxide (NO2) in Los Angeles County. We developed a novel approach to apportion the costs between these exposures under different pollution scenarios. Methods We integrated results from a study of willingness to pay to reduce the burden of asthma with studies of health care utilization and charges to estimate the costs of an asthma case and exacerbation. We applied those costs to the number of asthma cases and exacerbations due to regional pollution in 2007 and to hypothetical scenarios of a 20% reduction in regional pollution in combination with a 20% reduction or increase in the proportion of the total population living within 75m of a major roadway. Results Cost of air pollution-related asthma in Los Angeles County in 2007 was $441 million for O3 and $202 million for NO2 in 2010 dollars. Cost of routine care (care in absence of exacerbation) accounted for 18% of the combined NRP and O3 cost and 39% of the combined NRP and NO2 cost—costs not recognized in previous analyses. NRP-attributable asthma accounted for 43% (O3) to 51% (NO2) of the total annual cost of exacerbations and routine care associated with pollution. Hypothetical scenarios showed that costs from increased NRP exposure may offset savings from reduced regional pollution. Conclusions Our model disaggregates the costs of regional pollution and NRP exposure and illustrates how they might vary under alternative exposure scenarios. The cost of air pollution is a substantial burden on families and an economic loss for society. PMID:25439228

A hybrid liquid-phase precipitation (LPP) process in conjunction with membrane distillation (MD) for the treatment of the INEEL sodium-bearing liquid waste.

Science.gov (United States)

Bader, M S H

2005-05-20

A novel hybrid system combining liquid-phase precipitation (LPP) and membrane distillation (MD) is integrated for the treatment of the INEEL sodium-bearing liquid waste. The integrated system provides a "full separation" approach that consists of three main processing stages. The first stage is focused on the separation and recovery of nitric acid from the bulk of the waste stream using vacuum membrane distillation (VMD). In the second stage, polyvalent cations (mainly TRU elements and their fission products except cesium along with aluminum and other toxic metals) are separated from the bulk of monovalent anions and cations (dominantly sodium nitrate) by a front-end LPP. In the third stage, MD is used first to concentrate sodium nitrate to near saturation followed by a rear-end LPP to precipitate and separate sodium nitrate along with the remaining minor species from the bulk of the aqueous phase. The LPP-MD hybrid system uses a small amount of an additive and energy to carry out the treatment, addresses multiple critical species, extracts an economic value from some of waste species, generates minimal waste with suitable disposal paths, and offers rapid deployment. As such, the LPP-MD could be a valuable tool for multiple needs across the DOE complex where no effective or economic alternatives are available.

Design and implementation of an ASIP-based cryptography processor for AES, IDEA, and MD5

Directory of Open Access Journals (Sweden)

Karim Shahbazi

2017-08-01

Full Text Available In this paper, a new 32-bit ASIP-based crypto processor for AES, IDEA, and MD5 is designed. The instruction-set consists of both general purpose and specific instructions for the above cryptographic algorithms. The proposed architecture has nine function units and two data buses. It has also two types of 32-bit instruction formats for executing Memory Reference (M.R., Register Reference (R.R., and Input/Output Reference (I/O R. instructions. The maximum achieved frequency is 166.916 MHz. The encoded output results of the encryption process of a 128-bit input block are obtained after 122, 146 and 170 clock cycles for AES-128, AES-192, and AES-256, respectively. Moreover, it takes 95 clock cycles to encrypt or decrypt a 64-bit input block by using IDEA. Finally, the MD5 hash algorithm requires 469 clock cycles to generate the coded outputs for a block of 512 bits. The performance of the proposed processor is compared to some previous and state-of-the-art implementations in terms of speed, latency, throughput, and flexibility.

Alpha-gamma decay studies of 253No and its daughter products 253Md, 249Fm

International Nuclear Information System (INIS)

Hessberger, F.P.; Antalic, S.; Kalaninova, Z.; Saro, S.; Venhart, M.; Ackermann, D.; Heinz, S.; Kindler, B.; Kojouharov, I.; Kuusiniemi, P.; Lommel, B.; Mann, R.; Sulignano, B.; Hofmann, S.; Streicher, B.; Leino, M.; Nishio, K.

2012-01-01

Nuclear structure and decay of the isotope 253 No and its decay products 249 Fm and 253 Md were investigated by means of α - γ spectroscopy. Besides the established strong γ transitions from the 9/2 - [734] Nilsson level in 249 Fm, populated predominantly by the α decay of 253 No, into the ground-state (gs) rotational band, a couple of weaker γ lines (58.3, 129.2, 209.3 and 669.5keV) were observed and placed into the 249 Fm level scheme. The transition from the 7/2 - level in 249 Es, populated by the α decay of 253 Md, into the 9/2 + member of the gs rotational band, so far established for other odd-mass Es isotopes, was observed clearly. GEANT4 simulations were performed to investigate the influence of energy summing between α particles and conversion electrons (CE) on the shape of the α spectra at different implantation energies, leading to evidence for a weak α decay branch of 253 No into the gs of 249 Fm or the ground-state rotational band, respectively. (orig.)

Emission of Methane and Heavier Alkanes From the La Brea Tar Pits Seepage Area, Los Angeles

Science.gov (United States)

Etiope, G.; Doezema, L. A.; Pacheco, C.

2017-11-01

Natural hydrocarbon (oil and gas) seeps are widespread in Los Angeles, California, due to gas migration, along faults, from numerous subsurface petroleum fields. These seeps may represent important natural contributors of methane (CH4) and heavier alkanes (C2-C4) to the atmosphere, in addition to anthropogenic fossil fuel and biogenic sources. We measured the CH4 flux by closed-chamber method from the La Brea Tar Pits park (0.1 km2), one of the largest seepage sites in Los Angeles. The gas seepage occurs throughout the park, not only from visible oil-asphalt seeps but also diffusely from the soil, affecting grass physiology. About 500 kg CH4 d-1 is emitted from the park, especially along a belt of enhanced degassing that corresponds to the 6th Street Fault. Additional emissions are from bubble plumes in the lake within the park (order of 102-103 kg d-1) and at the intersection of Wilshire Boulevard and Curson Avenue (>130 kg d-1), along the same fault. The investigated area has the highest natural gas flux measured thus far for any onshore seepage zone in the USA. Gas migration, oil biodegradation, and secondary methanogenesis altered the molecular composition of the original gas accumulated in the Salt Lake Oil Field (>300 m deep), leading to high C1/C2+ and i-butane/n-butane ratios. These molecular alterations can be important tracers of natural seepage and should be considered in the atmospheric modeling of the relative contribution of fossil fuel (anthropogenic fugitive emission and natural geologic sources) versus biogenic sources of methane, on local and global scales.

MD simulation of cluster formation during sputtering

International Nuclear Information System (INIS)

Muramoto, T.; Okai, M.; Yamashita, Y.; Yorizane, K.; Yamamura, Y.

2001-01-01

The cluster ejection due to cluster impact on a solid surface is studied through molecular dynamics (MD) simulations. Simulations are performed for Cu cluster impacts on the Cu(1 1 1) surface for cluster energy 100 eV/atom, and for clusters of 6, 13, 28 and 55 atoms. Interatomic interactions are described by the AMLJ-EAM potential. The vibration energy spectrum is independent of the incident cluster size and energy. This comes from the fact that sputtered clusters become stable through the successive fragmentation of nascent large sputtered clusters. The vibration energy spectra for large sputtered clusters have a peak, whose energy corresponds to the melting temperature of Cu. The exponent of the power-law fit of the abundance distribution and the total sputtering yield for the cluster impacts are higher than that for the monatomic ion impacts with the same total energy, where the exponent δ is given by Y n ∝n δ and Y n is the yield of sputtered n-atom cluster. The exponent δ follows a unified function of the total sputtering yield, which is a monotonic increase function, and it is nearly equal to δ ∼ -3 for larger yield

Respiratory Syncytial Virus Fusion Protein-Induced Toll-Like Receptor 4 (TLR4) Signaling Is Inhibited by the TLR4 Antagonists Rhodobacter sphaeroides Lipopolysaccharide and Eritoran (E5564) and Requires Direct Interaction with MD-2

Science.gov (United States)

Rallabhandi, Prasad; Phillips, Rachel L.; Boukhvalova, Marina S.; Pletneva, Lioubov M.; Shirey, Kari Ann; Gioannini, Theresa L.; Weiss, Jerrold P.; Chow, Jesse C.; Hawkins, Lynn D.; Vogel, Stefanie N.; Blanco, Jorge C. G.

2012-01-01

ABSTRACT Respiratory syncytial virus (RSV) is a leading cause of infant mortality worldwide. Toll-like receptor 4 (TLR4), a signaling receptor for structurally diverse microbe-associated molecular patterns, is activated by the RSV fusion (F) protein and by bacterial lipopolysaccharide (LPS) in a CD14-dependent manner. TLR4 signaling by LPS also requires the presence of an additional protein, MD-2. Thus, it is possible that F protein-mediated TLR4 activation relies on MD-2 as well, although this hypothesis has not been formally tested. LPS-free RSV F protein was found to activate NF-κB in HEK293T transfectants that express wild-type (WT) TLR4 and CD14, but only when MD-2 was coexpressed. These findings were confirmed by measuring F-protein-induced interleukin 1β (IL-1β) mRNA in WT versus MD-2−/− macrophages, where MD-2−/− macrophages failed to show IL-1β expression upon F-protein treatment, in contrast to the WT. Both Rhodobacter sphaeroides LPS and synthetic E5564 (eritoran), LPS antagonists that inhibit TLR4 signaling by binding a hydrophobic pocket in MD-2, significantly reduced RSV F-protein-mediated TLR4 activity in HEK293T-TLR4–CD14–MD-2 transfectants in a dose-dependent manner, while TLR4-independent NF-κB activation by tumor necrosis factor alpha (TNF-α) was unaffected. In vitro coimmunoprecipitation studies confirmed a physical interaction between native RSV F protein and MD-2. Further, we demonstrated that the N-terminal domain of the F1 segment of RSV F protein interacts with MD-2. These data provide new insights into the importance of MD-2 in RSV F-protein-mediated TLR4 activation. Thus, targeting the interaction between MD-2 and RSV F protein may potentially lead to novel therapeutic approaches to help control RSV-induced inflammation and pathology. PMID:22872782

Elderly homeless veterans in Los Angeles: chronicity and precipitants of homelessness.

Science.gov (United States)

van den Berk-Clark, Carissa; McGuire, James

2013-12-01

We compared the characteristics of chronically homeless and acutely homeless elderly veterans to better understand precipitants of homelessness. We conducted interviews with 33 chronically and 26 acutely homeless veterans aged 65 years and older receiving transitional housing services in Los Angeles, California, between 2003 and 2005. We asked questions regarding their sociodemographic characteristics and other social status measures. Other precipitants of homelessness were acquired via observation and open-ended and structured questions. Both veterans groups were more similar than different, with substantial levels of physical, psychiatric, and social impairment. They differed significantly in homelessness history, with chronically homeless veterans having more homelessness episodes and more total time homeless. They were also less educated and had smaller social networks. In response to open-ended questioning, elderly homeless veterans revealed how health and substance use issues interacted with loss of social support and eviction to exacerbate homelessness. Assessment of a range of factors is needed to address risk factors and events leading to homelessness. Further research with larger samples is needed to confirm the characteristics and needs of the elderly homeless veteran population.

A workshop on leadership for MD/PhD students

Directory of Open Access Journals (Sweden)

Mark D. Cannon

2011-08-01

Full Text Available Success in academic medicine requires scientific and clinical aptitude and the ability to lead a team effectively. Although combined MD/PhD training programs invest considerably in the former, they often do not provide structured educational opportunities in leadership, especially as applied to investigative medicine. To fill a critical knowledge gap in physician-scientist training, the Vanderbilt Medical Scientist Training Program (MSTP developed a biennial two-day workshop in investigative leadership. MSTP students worked in partnership with content experts to develop a case-based curriculum and deliver the material. In its initial three offerings in 2006, 2008, and 2010, the workshop was judged by MSTP student attendees to be highly effective. The Vanderbilt MSTP Leadership Workshop offers a blueprint for collaborative student-faculty interactions in curriculum design and a new educational modality for physician-scientist training.

Synergistic Applications of MD and NMR for the Study of Biological Systems

Directory of Open Access Journals (Sweden)

Olivier Fisette

2012-01-01

same time, theoretical and computational approaches gain in reliability and their field of application widens. In this short paper, we discuss recent advances in the areas of solution nuclear magnetic resonance (NMR spectroscopy and molecular dynamics (MD simulations that were made possible by the combination of both methods, that is, through their synergistic use. We present the main NMR observables and parameters that can be computed from simulations, and how they are used in a variety of complementary applications, including dynamics studies, model-free analysis, force field validation, and structural studies.

Los Angeles International Airport Runway Incursion Studies: Phase III--Center-Taxiway Simulation

Science.gov (United States)

Madson, Michael D.

2004-01-01

Phase III of the Los Angeles International Airport Runway Incursion Studies was conducted, under an agreement with HNTB Corporation, at the NASA Ames FutureFlight Central (FFC) facility in June 2003. The objective of the study was the evaluation of a new center-taxiway concept at LAX. This study is an extension of the Phase I and Phase II studies previously conducted at FFC. This report presents results from Phase III of the study, in which a center-taxiway concept between runways 25L and 25R was simulated and evaluated. Phase III data were compared objectively against the Baseline data. Subjective evaluations by participating LAX controllers were obtained with regard to workload, efficiency, and safety criteria. To facilitate a valid comparison between Baseline and Phase III data, the same scenarios were used for Phase III that were tested during Phases I and II. This required briefing participating controllers on differences in airport and airline operations between 2001 and today.

Measuring Health Information Dissemination and Identifying Target Interest Communities on Twitter: Methods Development and Case Study of the @SafetyMD Network.

Science.gov (United States)

Kandadai, Venk; Yang, Haodong; Jiang, Ling; Yang, Christopher C; Fleisher, Linda; Winston, Flaura Koplin

2016-05-05

Little is known about the ability of individual stakeholder groups to achieve health information dissemination goals through Twitter. This study aimed to develop and apply methods for the systematic evaluation and optimization of health information dissemination by stakeholders through Twitter. Tweet content from 1790 followers of @SafetyMD (July-November 2012) was examined. User emphasis, a new indicator of Twitter information dissemination, was defined and applied to retweets across two levels of retweeters originating from @SafetyMD. User interest clusters were identified based on principal component analysis (PCA) and hierarchical cluster analysis (HCA) of a random sample of 170 followers. User emphasis of keywords remained across levels but decreased by 9.5 percentage points. PCA and HCA identified 12 statistically unique clusters of followers within the @SafetyMD Twitter network. This study is one of the first to develop methods for use by stakeholders to evaluate and optimize their use of Twitter to disseminate health information. Our new methods provide preliminary evidence that individual stakeholders can evaluate the effectiveness of health information dissemination and create content-specific clusters for more specific targeted messaging.

Investigating Bidirectional Reflectance in the Los Angeles Megacity Using CLARS Multiangle and Hyperspectral Measurements

Science.gov (United States)

Zeng, Z. C.; Natraj, V.; Pongetti, T.; Shia, R. L.; Sander, S. P.; Yung, Y. L.

2017-12-01

The surface reflectance is a key ingredient in the remote sensing of surface and atmospheric properties from space. The determination of atmospheric composition, including greenhouse gas (GHG) and aerosol concentrations, from reflected sunlight requires accurate knowledge of the contribution from the underlying surface. Over megacity areas, such as the Los Angeles (LA) basin, which are major sources of GHGs and anthropogenic aerosols, the quantification of surface reflectance is challenging due to the associated complex land use types. In this study, we investigate the bidirectional reflectance in the Los Angeles megacity area using multiangle and hyperspectral radiance measurements from the California Laboratory for Atmospheric Remote Sensing (CLARS). The CLARS facility is located near the top of Mt. Wilson, at an altitude of 1670 m a.s.l., overlooking the LA megacity area with an FTS operating since 2011 to continuously monitor the GHGs and near-surface aerosols in the basin. The CLARS-FTS offers continuous high-resolution spectral measurements in the visible, near infrared and shortwave infrared spectral regions. The CLARS measurements mimic the off-nadir viewing of a low-Earth orbiting instrument, such as GOSAT and OCO-2, but with daily viewing capability. Eight surface targets with different land use types, including urban parks, industrial and residential areas, are selected in this study. The surface reflectance for specific solar incident and viewing angles is calculated by dividing, for non-absorbing spectral channels on clear days (such that gas and aerosol extinction can be ignored), the observed radiance reflected from surface targets by the observed irradiance. The non-linear Rahman-Pinty-Verstraete (RPV) model is used to model the Bidirectional Reflectance Distribution Function (BRDF) by fitting the multiangle and hyperspectral measurements. By evaluating the retrieved RPV parameters, we find that the RPV model provides a good representation of the

Dissecting the Science of "Angels and Demons" or Antimatter and Other Matters (Vernon W. Hughes Memorial Lecture)

Energy Technology Data Exchange (ETDEWEB)

Gordon, Howard

2009-05-27

Howard Gordon, a physicist from the U.S. Department of Energy’s Brookhaven National Laboratory, and local educators will separate the science facts from the science fiction of “Angels & Demons,” a major motion picture based on Dan Brown’s best-selling novel. The film, which opens nationally in theaters today, focuses on a plot to destroy the Vatican using antimatter stolen from the Large Hadron Collider (LHC) at the European particle physics laboratory CERN. Speakers will explain the real science of the LHC, including antimatter – oppositely charged cousins of ordinary matter with intriguing properties.

75 FR 31509 - Rescinding the Notice of Intent for an Environmental Impact Statement: Prince George's County, MD

Science.gov (United States)

2010-06-03

... DEPARTMENT OF TRANSPORTATION Federal Highway Administration Rescinding the Notice of Intent for an Environmental Impact Statement: Prince George's County, MD AGENCY: Federal Highway Administration. ACTION... Statement that was issued on June 11, 2008, for a proposed roadway improvement project in Prince George's...

Theoretical analysis of the domain-swapped dimerization of cytochrome c: An MD and 3D-RISM approach

Science.gov (United States)

Yoshida, Norio; Higashi, Masahiro; Motoki, Hideyoshi; Hirota, Shun

2018-01-01

The structural stability of a cytochrome c domain-swapped dimer compared with that of the monomer was investigated by molecular dynamics (MD) simulations and by three-dimensional reference interaction site model (3D-RISM) theory. The structural fluctuation and structural energy of cytochrome c were treated by MD simulations, and the solvation thermodynamics was treated by 3D-RISM theory. The domain-swapped dimer state is slightly less stable than the monomer state, which is consistent with experimental observations; the total free energy difference is calculated as 25 kcal mol-1. The conformational change and translational/rotational entropy change contribute to the destabilization of the dimer, whereas the hydration and vibrational entropy contribute to the stabilization. Further analyses on the residues located at the hinge loop for swapping were conducted, and the results reveal details at the molecular level of the structural and interaction changes upon dimerization.

Groundwater quality in the Coastal Los Angeles Basin, California

Science.gov (United States)

Fram, Miranda S.; Belitz, Kenneth

2012-01-01

The Coastal Los Angeles Basin study unit is approximately 860 square miles and consists of the Santa Monica, Hollywood, West Coast, Central, and Orange County Coastal Plain groundwater basins (California Department of Water Resources, 2003). The basins are bounded in part by faults, including the Newport-Inglewood fault zone, and are filled with Holocene-, Pleistocene-, and Pliocene-age marine and alluvial sediments. The Central Basin and Orange County Coastal Plain are divided into a forebay zone on the northeast and a pressure zone in the center and southwest. The forebays consist of unconsolidated coarser sediment, and the pressure zones are characterized by lenses of coarser sediment divided into confined to semi-confined aquifers by lenses of finer sediments. The primary aquifer system in the study unit is defined as those parts of the aquifer system corresponding to the perforated intervals of wells listed in the California Department of Public Health (CDPH) database of public-supply wells. The majority of public-supply wells are drilled to depths of 510 to 1,145 feet, consist of solid casing from the land surface to a depth of about 300 to 510 feet, and are perforated below the solid casing. Water quality in the primary aquifer system may differ from that in the shallower and deeper parts of the aquifer systems.

Physicians' reaction to Chernobyl explosion: lessons in radiation - and cooperation

International Nuclear Information System (INIS)

Anon.

1986-01-01

Although the Soviets originally refused offers of technical assistance from many other nations, they accepted one offer of assistance almost immediately - help in the medical care of those who had been exposed to radiation. The offer to provide medical assistance was initiated by the International Bone Marrow Transplant Registry on April 29 by its chair, Robert Peter Gale, MD, PhD, of the Univ. of California at Los Angeles. It was accepted on May 1. This paper discusses his medical experiences and observations on the Chernobyl accident