WorldWideScience

Sample records for andrology

  1. Robotic assisted andrological surgery

    Institute of Scientific and Technical Information of China (English)

    Sijo J Parekattil; Ahmet Gudeloglu

    2013-01-01

    The introduction of the operative microscope for andrological surgery in the 1970s provided enhanced magnification and accuracy,unparalleled to any previous visual loop or magnification techniques.This technology revolutionized techniques for microsurgery in andrology.Today,we may be on the verge of a second such revolution by the incorporation of robotic assisted platforms for microsurgery in andrology.Robotic assisted microsurgery is being utilized to a greater degree in andrology and a number of other microsurgical fields,such as ophthalmology,hand surgery,plastics and reconstructive surgery.The potential advantages of robotic assisted platforms include elimination of tremor,improved stability,surgeon ergonomics,scalability of motion,multi-input visual interphases with up to three simultaneous visual views,enhanced magnification,and the ability to manipulate three surgical instruments and cameras simultaneously.This review paper begins with the historical development of robotic microsurgery.It then provides an in-depth presentation of the technique and outcomes of common robotic microsurgical andrological procedures,such as vasectomy reversal,subinguinal varicocelectomy,targeted spermatic cord denervation (for chronic orchialgia) and robotic assisted microsurgical testicular sperm extraction (microTESE).

  2. Interdisciplinary andrology. STDs. AIDS research.

    Science.gov (United States)

    Hafez, E S

    1987-01-01

    Multidisciplinary andrology deals with clinical application and modern technology for the evaluation and differential diagnosis of male infertility with emphasis on morphological, anatomical, biochemical, immunological, hereditary, and microbiological parameters. Little is known about the effects of diet, disease, stress, environmental, and drugs on male-related unexplained infertility of couples. Regional, national, and international centers of multidisciplinary andrology should provide (1) extensive and unique clinical services; (2) a computerized "patient referral center," (3) self-learning packages (slides/tape programs) for patients; and (4) a computer link to the National Library of Medicine and the Drug Information Center. Specialized laboratories and clinics can be served by expert consultants, visiting professors, bilingual and well-trained clinicians, nurses, laboratory technologists, computer operators, and related allied health personnel. Patient education pamphlets, updated every few years, can be distributed during training workshops when an extensive network of remote teleprinters can be utilized. Qualified client location may install a printer to allow on-site printing of reports in the shortest possible time. Special mailing containers are provided to clients who wish to mail their laboratory specimens. Other clinical services may include the following: 1. Central source of communication and information in andrology; 2. International roster of multidisciplinary andrology centers; 3. Patient referral to centers and consultations for developing countries; 4. Screening of husbands and wives for in vitro fertilization/embryo transfer (IVF/ET); 5. Screening of couples with unexplained infertility for sexually transmitted diseases (STDs) including AIDS; 6. Exchange of research material and methodology; 7. Coordination of multicenter research; 8. Organizing training workshops for clinicians, nurses, and laboratory technicians; 9. Establishing a repository

  3. [Lumbar disc herniation and andrological diseases].

    Science.gov (United States)

    Jin, Bao-fang

    2015-10-01

    Lumbar disc herniation is a common male disease. In the past, More academic attention was directed to its relationship with lumbago and leg pain than to its association with andrological diseases. Studies show that central lumber intervertebral disc herniation may cause cauda equina injury and result in premature ejaculation, erectile dysfunction, chronic pelvic pain syndrome, priapism, and emission. This article presents an overview on the correlation between central lumbar intervertebral disc herniation and andrological diseases, focusing on the aspects of etiology, pathology, and clinical progress, hoping to invite more attention from andrological and osteological clinicians. PMID:26665671

  4. For a history of andrology.

    Science.gov (United States)

    Angeletti, L R

    2001-01-01

    Two issues of this Journal are devoted to the history of andrology and male sexuality, from Hippocratic medicine to contemporary ethical problems due to the increasing role of technology in human reproduction. Studies have been devoted to: the Hippocratic Corpus, to authors of the Roman Empire, to Byzantine medicine; the transmission of ancient texts through Arabic and other languages of the Middle East; the influence of Constantinus Africanus' translations from Arabic to Latin; early modern theories about semen, male sexuality, impotence. Recent developments of biochemistry and epistemology are analyzed to show how these and other topics have influenced sexual ideas and behaviours until the discovery - around 1840 - of the chemical nature of male sexual hormones. In more recent years, technologies and cellular and molecular biology have opened new perspectives in the fields of fertilization and male sexuality, giving way at the same to new ethical, social and legal problems. PMID:12365435

  5. Andrology laboratory review: Evaluation of sperm concentration.

    Science.gov (United States)

    Brito, Leonardo F C; Althouse, Gary C; Aurich, Christine; Chenoweth, Peter J; Eilts, Bruce E; Love, Charles C; Luvoni, Gaia C; Mitchell, Jere R; Peter, Augustine T; Pugh, David G; Waberski, Dagmar

    2016-06-01

    This article is the result of the work of the andrology task-force of the Association of Applied Animal Andrology, American College of Theriogenologists, European College of Animal Reproduction, Society for Theriogenology, and National Association of Animal Breeders. It is intended to serve as a comprehensive reference on methods to evaluate sperm concentration and to contribute to the adoption of best practices in veterinary andrology laboratories. The information covered in the article includes sample preparation and the use of manual counts, spectrophotometers, computer-assisted semen analysis, NucleoCounter, and flow cytometry. Emphasis is given to the principles of the methods and equipment, performing the evaluation, and common mistakes and/or pitfalls. In addition, the precision and accuracy of the different methods are also discussed. PMID:27045626

  6. New flow cytometry approaches in equine andrology.

    Science.gov (United States)

    Peña, Fernando J; Ortega Ferrusola, Cristina; Martín Muñoz, Patricia

    2016-07-01

    Flow cytometry is currently recognized as a robust tool for the evaluation of sperm quality and function. However, within equine reproduction, this technique has not reached the sophistication of other areas of biology and medicine. In recent years, more sophisticated flow cytometers have been introduced in andrology laboratories, and the number of tests that can be potentially used in the evaluation of sperm physiology has increased accordingly. In this review, recent advances in the evaluation of stallion spermatozoa will be discussed. These new techniques in flow cytometry are able to simultaneously measure damage to different sperm regions and/or changes in functionality. PMID:27160445

  7. AB27. Introduction to Asian Journal of Andrology

    OpenAIRE

    Ren, Danqing

    2014-01-01

    Asian Journal of Andrology (AJA, http://www.asiaandro.com) is an international peer-reviewed open access journal. It is sponsored by the Shanghai Institute of MateriaMedica at the Chinese Academy of Sciences and Shanghai Jiao Tong University. Its Editor-in-Chief is Prof Yi-Fei Wang who is an internationally well-known reproductive expert. Its recent SCI Impact factor is 2.140. It could become higher this year. AJA warmly welcome submissions in English from all of the world. With a focus on ne...

  8. A Summary of the Third Asian and Oceanic Congress of Andrology

    Institute of Scientific and Technical Information of China (English)

    HaruoIto

    2000-01-01

    The Third Asian and Oceanic Congress of Andrology was held on May 24 - 27, 2000, at Makuhari Messe, Chiba, Japan. The Congress Proper was preceded by a Post-graduate Course entitled "Operative Andrology". In the Course, doctors in leading positions gave lectures on the advanced surgical technologies of andrology. A video unit was available that greatly assisted the participants to get hold of the new knowledge. The following surgical techniques were presented: MESA/TESE, vaso-vasostomy and epididymo-vasostomy, microsurgical subinguinal varicocelectomy, nerve-sparing retroperitoneal lymph node dissection, and one-day penile prosthesis surgery.

  9. Psychosomatic approaches to obstetrics, gynaecology and andrology--a review.

    Science.gov (United States)

    Lal, Mira

    2009-01-01

    This review aims to clarify the scope and clinical importance of psychosomatic approaches to obstetrics, gynaecology and andrology. This gradually expanding sub-specialty covers a wide domain of complex disease conditions that can be managed more effectively if the various biological, psychological and social aspects are recognised at the start and concurrent treatment initiated. The current need to practise biopsychosocial management of disease conditions is highlighted along with a description of what this would involve. The nine-field psychosomatic approach, which can be applied to everyday clinical encounters, has been illustrated. Clinical applications of the psychosomatic approach are discussed for various conditions including chronic pelvic pain, eating disorders, tokophobia, post-traumatic stress disorder, depression, menstrual disorders, infertility, bereavement and testicular cancer. Cultural considerations and the need for further research are also briefly discussed. PMID:19280487

  10. [Andrological status of adolescents and its connection to anthropometric and hormonal descriptions in the students of technical college group].

    Science.gov (United States)

    Lutov, Iu V; Seliatitskaia, V G; Epanchintseva, E A; Riabichenko, T I

    2014-01-01

    The purpose of this investigation was to study the interrelation of andrological status with anthropometric and hormonal descriptions for age-specific features discovery of male sexual system pathological states at technical college students. 147 adolescents aged 15-17 years old were examined. Only 41 of them were found to have no abnormalities in their genital system development; in 35 adolescents sexual development was delayed; and 97 adolescents were found to have various andrological diseases (varicocele, phimosis, gynecomastia, testicular asymmetry, etc.) or clinical signs for development of these diseases. In 26 adolescences delayed sexual development was combined with the andrological pathology. The normal andrological status was usually accompanied with the highest frequency of low values of anthropometric indicators and indices that reflect the influence of various hormonal systems on the bodily constitution, as well as expressed anthropometricheterogeneity. In adolescents with andrological pathology or clinical signs for its development, in all anthropometric parameters the higher values were seen more frequently than low values against the background of highest group anthropometric homogeneity. Summative anthropometric characteristics of the adolescents group with delayed sexual development were between those of the adolescents groups with normal andrological status and andrological pathology The number of correlational relationships of anthropometric and hormonal indicators with the levels of cortisol and dehydroepiandrosteronesulphate was the lowest in the group of adolescents with normal andrological status as compared to their peers with delayed sexual development and andrological pathology. Only in the group of adolescents with normal andrological status the correlation analysis of data showed physiological influence of sexual hormones on anthropometric indicators. Thus, lower influence of sexual system hormones during this ontogenesis stage

  11. Practical recommendations for performing ultrasound scanning in the urological and andrological fields

    Directory of Open Access Journals (Sweden)

    Pasquale Martino

    2014-03-01

    Full Text Available Aim: US scanning has been defined as the urologist’s stethoscope. These recommendations have been drawn up with the aim of ensuring minimum standards of excellence for ultrasound imaging in urological and andrological practice. A series of essential recommendations are made, to be followed during ultrasound investigations in kidney, prostate, bladder, scrotal and penile diseases. Methods: Members of the Imaging Working Group of the Italian Society of Urology (SIU in collaboration with the Italian Society of Ultrasound in Urology, Andrology and Nephrology (SIEUN identified expert Urologists, Andrologists, Nephrologists and Radiologists. The recommendations are based on review of the literature, previously published recommendations, books and the opinions of the experts. The final document was reviewed by national experts, including members of the Italian Society of Radiology. Results: Recommendations are listed in 5 chapters, focused on: kidney, bladder, prostate and seminal vesicles, scrotum and testis, penis, including penile echo-doppler. In each chapter clear definitions are made of: indications, technological standards of the devices, the method of performance of the investigation. The findings to be reported are described and discussed, and examples of final reports for each organ are included. In the tables, the ultrasound features of the principal male uro-genital diseases are summarized. Diagnostic accuracy and second level investigations are considered. Conclusions: Ultrasound is an integral part of the diagnosis and follow-up of diseases of the urinary system and male genitals in patients of all ages, in both the hospital and outpatient setting. These recommendations are dedicated to enhancing communication and evidence-based medicine in an inter- and multi-disciplinary approach. The ability to perform and interpret ultrasound imaging correctly has become an integral part of clinical practice in uro-andrology, but intra and inter

  12. Cytogenetic and andrological status and ICSI-results in couples with severe male factor infertility

    Institute of Scientific and Technical Information of China (English)

    G.Haidl; B.Peschka; G.Schwanitz; M.Montag; K.vanderVen; H.vanderVen

    2000-01-01

    Aim: To pursue whether cytogenetic aberrations correlate with specific spermatological or hormonal abnormalities.Methods: 305 infertile couples were investigated. All male partners were referred to a complete andrological workup with physical examination, determination of hormones, HIV testing and semen analysis. Cytogenetic analysis was carried out in both partners by means of standard techniques using cultured lymphocytes from peripheral blood. Results: Among the 305 couples, 10 men (3.2%) and 10 women (3.2%) showed constitutional chromosomal aberrations, including reciprocal translocations (n=7), Robertsonian translocations (n=3), inversions (n=3), other structural aberrations (n=4) and sex chromosome aberrations (n=3). In addition to the impaired sperm count in most of the patients, a tendency to an increased proportion of spermatozoa with acrosome defect was observed. Conclusion. Chromosomal aberrations may contribute to the low fertilization and pregnancy rates in the infertile couples.(Asian J Androl 2000 Dec;2:293-296)

  13. Novel approaches in andrology examination and follicular fluid biochemical characterization in the optimization of reproductive technologies in farm animals

    OpenAIRE

    Vencato, Juri

    2014-01-01

    The purpose of the studies reported in this Thesis was to increase our understanding of two aspects of the reproductive system in farm animals: the andrological evaluation and the follicular fluid composition. The final aim was to give some tools that can be helpful in optimizing the application of assisted reproductive technologies. Studies were conducted in bulls, rams, alpacas, lamas and dairy buffalo cows. The first study was designed to investigate the efficacy of scrotal thermograp...

  14. Optimising workflow in andrology: a new electronic patient record and database

    Institute of Scientific and Technical Information of China (English)

    Frank Tüttelmann; C. Marc Luetjens; Eberhard Nieschlag

    2006-01-01

    Aim: To improve workflow and usability by introduction of a new electronic patient record (EPR) and database.Methods: Establishment of an EPR based on open source technology (MySQL database and PHP scripting language)in a tertiary care andrology center at a university clinic. Workflow analysis, a benchmark comparing the two systems and a survey for usability and ergonomics were carried out, Results: Worlflow optimizations (electronic ordering of laboratory analysis, elimination of transcription steps and automated referral letters) and the decrease in time required for data entry per patient to 71% ± 27%, P<0.05, lead to a workload reduction. The benchmark showed a significant performance increase (highest with starting the respective system: 1.3 ± 0.2 s vs. 11.1 ± 0.2 s, mean ± SD). In the survey, users rated the new system at least two ranks higher over its predecessor (P<0.01) in all sub-areas.Conclusion: With further improvements, today's EPR can evolve to substitute paper records, saving time (and possibly costs), supporting user satisfaction and expanding the basis for scientific evaluation when more data is electronically available. Newly introduced systems should be versatile, adaptable for users, and workflow-oriented to yield the highest benefit. If ready-made software is purchased, customization should be implemented during rollout.

  15. Creating a "one-stop shop" for all the most interesting findings from across the field of andrology——Asian Journal of Andrology launches Research Highlights

    Institute of Scientific and Technical Information of China (English)

    Yi-Fei Wang

    2010-01-01

    @@ Thumbing the pages of various scientific journals a researcher might wonder: how do 1 efficiently and accurately identify articles that invoke my enthusiasm while informing me of important breakthroughs across the field of andrology? Skimming through an interesting article: how do 1 thoroughly and incisively comprehend the significance of the findings? Closing the article pages: how do 1 integrate the conclusions derived from the findings into my own research? Asian Journal of Andrology (AJA) would like to provide you an efficient information platform to address these questions through a brand new article type--Research Highlights.

  16. Prevalence of premature ejaculation in young and middle-aged men in Korea: a multicenter internet-based survey from the Korean Andrological Society

    OpenAIRE

    Park, Hyun Jun; Park, Jong Kwan; Park, Kwangsung; Lee, Sung Won; Kim, Sae-Woong; Yang, Dae Yul; Moon, Du Geon; Min, Kweon-Sik; Moon, Ki-Hak; Yang, Sang-Kuk; Hyun, Jae Seog; Park, Nam Cheol

    2010-01-01

    In this study, we aimed to investigate the prevalence and perception of premature ejaculation (PE) in young and middle-aged Korean men. The study was conducted using an Internet-assisted questionnaire. A total of 2 037 Korean male adults, aged 20 years or older, were randomly sampled based on age and residency. The questionnaire developed by the PE Study Group of the Korean Andrological Society includes four categories (overall sexual function, symptoms, distress and treatment) with a total o...

  17. 2016 Laboratory guidelines for postvasectomy semen analysis: Association of Biomedical Andrologists, the British Andrology Society and the British Association of Urological Surgeons.

    Science.gov (United States)

    Hancock, P; Woodward, B J; Muneer, A; Kirkman-Brown, J C

    2016-07-01

    Post-vasectomy semen analysis (PVSA) is the procedure used to establish whether sperm are present in the semen following a vasectomy. PVSA is presently carried out by a wide variety of individuals, ranging from doctors and nurses in general practitioner (GP) surgeries to specialist scientists in andrology laboratories, with highly variable results.Key recommendations are that: (1) PVSA should take place a minimum of 12 weeks after surgery and after a minimum of 20 ejaculations. (2) Laboratories should routinely examine samples within 4 h of production if assessing for the presence of sperm. If non-motile sperm are observed, further samples must be examined within 1 h of production. (3) Assessment of a single sample is acceptable to confirm vasectomy success if all recommendations and laboratory methodology are met and no sperm are observed. Clearance can then be given. (4) The level for special clearance should be methods contained within these guidelines. Surgeons are responsible both preoperatively and postoperatively for the counselling of patients and their partners regarding complications and the possibility of late recanalisation after clearance. These 2016 guidelines replace the 2002 British Andrology Society (BAS) laboratory guidelines and should be regarded as definitive for the UK in the provision of a quality PVSA service, accredited to ISO 15189:2012, as overseen by the United Kingdom Accreditation Service (UKAS). PMID:27083211

  18. Position and category of traditional Chinese andrology and relationship with discipline development%论中医男科学的学科地位和范畴与学科发展的关系

    Institute of Scientific and Technical Information of China (English)

    秦国政; 王沛; 李曰庆

    1997-01-01

    The traditional Chinese and andrology can be traced back to the ancient Chinese medical literature over 3000 years ago describing the diseases of male set,but it is only since mid 1980s of century whtn it was differentiated from traditional Chinese clinical medicine into an independent discipline that it has a great boom.The exact concept of this discipline was first presented and published in the literature in 1986.With concerted efforts of traditional Chinese andrologists,the discipline has been systematically established,enriched in content,properly categorized and progressively developed.However,judging from its present theoretical and clinical studies,the traditional Chinese andrology has not a uniform and definite positon in the entire system of traditional Chinese medicine and clinical disciplines,a due position in medical teaching and a far from uniform position in academic organizations.Seeing from the published literature and monographs,the discipline category of traditional Chinese andrology is also not uniform.All of this hinders the further development of the discipline.Therefore,in this paper the positioning and categorization of traditional Chinese andrology and their relationship with the development of the discipline are discussed.

  19. Advancement in biochemical assays in andrology

    Institute of Scientific and Technical Information of China (English)

    Wolf-BernhardSchill; RaftHenkel

    1999-01-01

    Determination of maikers of sperm function, accessory sex gland secretion and silent male genital tract inflammation is of considerable diagnostic value in the evaluation of male infertility. The introduction of biochemical tests into the analysis of male factor has the advantage that standardized assays with a coefficient of variafion characteristic of clinical chemistry are performed, in contrast to biological test systems with a large variability .Biochemical parameters may be used in clinical practice to evaluate the sperm fertitizing capacity (acrosin, aniline blue,ROS), to characterize male accessory sex gland secretinns (fructose, a-glucosidase, PSA), and to identify men with silent genital tract inflammation (elastase, C'3 complement component, coeruloplasmin, IgA, IgG, ROS). (As/an J Androl 1999 Jun; 1: 45-51)

  20. Associação entre o perfil andrológico e a congelação de sêmen de touros da raça Nelore aos dois anos de idade, pré-selecionados pela classificação andrológica por pontos (CAP Relationship between andrologic profile and semen freezing in two-year-old Nelore bulls, pre select by breeding soundness evaluation (BSE

    Directory of Open Access Journals (Sweden)

    D.F. Salvador

    2008-06-01

    Full Text Available Avaliaram-se as características andrológicas (n=163 e de congelação do sêmen (n=55 de touros jovens da raça Nelore e estudou-se a associação entre essas avaliações, visando à localização de marcadores para alta fertilidade e congelabilidade do sêmen. Registraram-se diferenças (PAndrologic (n=163 and semen freezing (n=55 parameters from young Nelore bulls were evaluated for two consecutive years, as well as their associations searching for andrologic markers for high fertility and semen freezing. Differences in andrologic profiles (P<0.05 between years were registered, reflecting the success of semen freezing, even after andrologic selection. Percentages of 26.6 and 19.5 of discharged ejaculates, pre and post-freezing, respectively, were recorded, due to physical semen parameters. Overall sperm motility, vigor, and viability means were, respectively, 66.4±5.7%, 4.8±0.4, and 76.3±8.5% pre-freezing; and 29.4±8.5%, 4.6±0.6, and 34.5±11.1% post-freezing. The post-freezing recovery mean was 44.5±13.4%. Significant correlations (P<0.05 between body weight and pre-freezing sperm motility (0.43 and post-freezing sperm recovery standard (-0.50 were estimated. Correlations were also observed (P<0.05 between volume of ejaculate and age (0.50, sperm motility (0.28, total sperm defects (-0.32, and post-freezing sperm recovery standard (-0.37. The correlation between sperm concentration and post-freezing sperm recovery standard was 0.42. Significant correlations (P<0.05 between testes shape and scrotal circumference (0.58, and total sperm defects (0.33 and vesicular gland area (0.43 were also observed.

  1. The role of prolactin in andrology: what is new?

    Science.gov (United States)

    Rastrelli, Giulia; Corona, Giovanni; Maggi, Mario

    2015-09-01

    Prolactin (PRL) has been long deemed as a hormone involved only in female reproduction. However, PRL is a surprising hormone and, since its identification in the 1970s, its attributed functions have greatly increased. However, its specific role in male health is still widely unknown. Recently, low PRL has been associated with reduced ejaculate and seminal vesicle volume in infertile subjects. In addition, in men consulting for sexual dysfunction, hypoprolactinemia has been associated with erectile dysfunction and premature ejaculation, findings further confirmed in the general European population and infertile men. Several metabolic derangements, recapitulating metabolic syndrome, have also been associated with low PRL both in men with sexual dysfunction and from the general European population. In men with sexual dysfunction, followed-up for more than 4 years, low PRL was identified as an independent predictor of the incidence of major adverse cardiovascular events. Finally, an association with anxiety or depressive symptoms has been found in men with sexual dysfunction and from the general European population. While a direct role for impaired PRL function in the pathogenesis of these reproductive, sexual, metabolic and psychological disorders is conceivable, the possibility that low PRL is a mirror of an increased dopaminergic or a decreased serotonergic tone cannot be ruled-out. Hyperactivity of the dopaminergic system can explain only a few of the aforementioned findings, whereas a hypo-serotonergic tone fits well with the clinical features associated with low PRL, and there is significant evidence supporting the hypothesis that PRL could be a mirror of serotonin in the brain. PMID:26542707

  2. Recent advances in andrology-related stem cell research

    Institute of Scientific and Technical Information of China (English)

    Ching-Shwun Lin; Zhong-Cheng Xin; Chun-Hua Deng; Hongxiu Ning; Ouiting Lin; Tom F. Lue

    2008-01-01

    Stem cells hold great promise for regenerative medicine because of their ability to self-renew and to differentiate into various cell types. Although embryonic stem cells (BSC) have greater differentiation potential than adult stem cells, the former is lagging in reaching clinical applications because of ethical concerns and governmental restrictions.Bone marrow stem cells (BMSC) are the best-studied adult stem cells (ASC) and have the potential to treat a wide variety of diseases, including erectile dysfunction (ED) and male infertility. More recently discovered adipose tissue-derived stem cells (ADSC) are virtually identical to bone marrow stem cells in differentiation and therapeutic potential,but are easier and safer to obtain, can be harvested in larger quantities, and have the associated benefit of reducing obesity. Therefore, ADSC appear to be a better choice for future clinical applications. We have previously shown that ESC could restore the erectile function of neurogenic ED in rats, and we now have evidence that ADSC could do so as well. We are also investigating whether ADSC can differentiate into Leydig, Sertoli and male germ cells. The eventual goal is to use ADSC to treat male infertility and testosterone deficiency.

  3. Andrology: Effect of Inseminated Volume on Intrauterine Insemination

    OpenAIRE

    Amaral, Vivian Ferreira do; Ferriani, Rui Alberto; Reis, Rosana Maria dos; de Sala, Maria Matheus; De Moura, Marcos Dias

    2001-01-01

    Purpose: Intrauterine insemination (IUI) is a method for the treatment of marital infertility involving the intrauterine or fallopian deposition of washed spermatozoa, depending on the amount of inseminated semen. In view of the divergent opinions about the inseminated volume, the objective of this study was to compare the two techniques (3.0 mL or 0.5 mL) in two groups of patients.

  4. Human testicular insulin-like factor 3: in relation to development, reproductive hormones and andrological disorders

    DEFF Research Database (Denmark)

    Bay, K; Andersson, A-M

    2011-01-01

    the endocrine regulation of this process. INSL3 is, along with testosterone, a major secretory product of testicular Leydig cells. In addition to its crucial function in testicular descent, INSL3 is suggested to play a paracrine role in germ cell survival and an endocrine role in bone metabolism. INSL3......, steroidogenic effects of LH, which for example is an important factor in the regulation of testosterone. Clinically, serum INSL3 levels can turn out to be a usable tool to monitor basal Leydig cell function in patients with various disorders affecting Leydig cell function. According to animal studies, foetal...... INSL3 production is, directly or indirectly, sensitive to oestrogenic or anti-androgenic compounds. This provides important insight into the mechanism by which maternal exposure to endocrine disrupters can result in cryptorchidism in the next generation. Conclusively, INSL3 is an interesting testicular...

  5. Foreword to men's health in Asia: special issue of Asian Journal of Andrology

    Institute of Scientific and Technical Information of China (English)

    Hui Meng Tan

    2011-01-01

    @@ Disease burden, risk factors for cardiometabolic diseases, life expectancies and health-related adjusted life expectancies vary greatly in Asian countries.The marked difference in socioeconomic status, cultural practices and health-care services further compound these discrepancies.As such, men's health status, men's health promotion, education as well as men's health care differ markedly in different parts of Asia.

  6. Detecting subtle changes in sperm membranes in veterinary andrology%兽医男科学中精子膜细微变化的检测

    Institute of Scientific and Technical Information of China (English)

    F. J. Pe(n)a

    2007-01-01

    在过去十年中由于流式细胞仪在兽医精子学中得到越来越多的应用,许多新的细胞膜完整性检测方法被开发出来.这些检测方法比精子的运动性监测等其它的检测更有助于预测生殖能力,因而显得十分重要.精子质量评估的主要部分演变为能在较早时期检测到精子损伤的检测.利用磷脂移位测试法,能通过荧光探针结合流式细胞仪评估大量精子的细胞膜渗透性和流动性早期的变化.%Thanks to the increasing use of flow cytometry in research in veterinary spermatology, many new membrane integrity assays have been developed over the past decade. These assays are important because of their superior ability to forecast fertility when compared with other tests, such as sperm motility. This major component of the sperm quality assessment has generated new investigations with the aim of developing tests that can detect membrane damage in a very early state. Using phospholipid transposition tests, early changes in membrane permeability and fluidity can be assessed in a large number of spermatozoa using fluorescent probes in combination with flow cytometry.

  7. Comment on "Effect of transferred NK4 gene on proliferation,migration, invasion, and apoptosis of human prostate cancer DU145 cells" by Dan Yue et al. in Asian Journal of Andrology

    Institute of Scientific and Technical Information of China (English)

    Shahriar Koochekpour

    2010-01-01

    @@ Hepatocyte growth factor/scatter factor (HGF/SF) interacting with its cell surface receptor tyrosine kinase (RTK) c-met proto-oncogene drives downstream signaling pathways which lead to cell proliferation, migration,invasion, apoptotic cell-death protection, angiogenesis during embryogenesis, repair and regeneration, and neoplastic growth and metastatic progression [1-6].

  8. The contribution of the ancient work "Miaoyizhai Medical Knowledge-the chapter on sexology" to andrology%《妙一斋医学正印编·种子编》对男科学的贡献

    Institute of Scientific and Technical Information of China (English)

    卞文伯

    2007-01-01

    岳甫嘉,字仲仁,号心翼,又号妙一斋主人,幼习举子业,屡试于乡不售,遂一意攻医,全治颇众,著《妙一斋医学正印编》16种,现有《种子编》及《女科证治全编》存世。

  9. An Observational Study to Evaluate the Prevalence of Erectile Dysfunction (ED) and Prescribing Pattern of Drugs in Patients with ED Visiting an Andrology Specialty Clinic, Mumbai: 2012-14

    Science.gov (United States)

    Kulkarni, Vijay R.; Bhagat, Sagar B.; Beldar, Amit S.; Patel, Sadiq B.

    2015-01-01

    Introduction: Erectile dysfunction (ED) is a common occurrence and its incidence is expected to increase significantly along with the increase in various lifestyle diseases. The drug utilization for ED is very low. Also, studies describing the prescription pattern in ED are lacking. Materials and Methods: We conducted a retrospective cross-sectional observational study, including a drug utilization analysis, of 606 prescriptions as per the standard guidelines (WHO and STROBE). Results: Out of 606, 249 (41%) were from the age group of 30-39 years. Addictions were present in 388 (64%). Out of 606, 186 had urological, 154 had cardiovascular and 102 had psychological co-morbid disorders. Out of 348, 201 were prescribed Tadalafil (low dose) on a once daily basis. Out of 172, 121 were prescribed Sildenafil (high dose) on an ‘as and when required’ basis. Nutritional/ herbal supplements were prescribed in 126/606. The ratio of ‘Prescribed Daily Dose’ to ‘Defined Daily Dose’ of Tadalafil, Sildenafil, and Dapoxetine were 1.1, 1.3 and 1.5 respectively. Conclusion: Measures for de-addiction play an important role in the overall management of ED. The most common co-morbid disorders were urological, like BPH, LUTS, etc, followed by cardiovascular, psychological and diabetes. Overall, rational pharmacotherapy was observed. Tadalafil was the most commonly prescribed drug for ED. The main factor in the selection of a particular PDE5 inhibitor was its pharmacokinetics and cost. Udenafil, being the costliest, was the least prescribed. Dapoxetine was used in a significant number of individuals primarily for PE with ED. The combination of Papaverine, Chlorpromazine ± Alprostadil was used as intracavernosal injection in patients not responding to oral drugs. PMID:26393163

  10. Information for Authors

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    General Asian Journal ofAndrology (AJA) is the official publication of the Asian Society of Andrology sponsored by the Shanghai Institute of Materia Medica, Chinese Academy of Sciences. The Journal has been included in 11 international indexing systems, including BIOSIS, CAB Abstracts, CAB Health, Chemical Abstracts, Current Contents/Clinical Medicine, EMBASE, Index Medicus, MEDLINE, PASCAL, Research Alert, and SCI Expanded. The Impact Factor is 1.064 and ranks third among the international andrology journals.

  11. Information for Authors

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    1 General Asian Journal of Andrology (AJA) is the official publication of the Asian Society of Andrology sponsored by the Shanghai Institute of Materia Medica, Chinese Academy of Sciences. The Journal has been included in 11 international indexing systems, including BIOSIS, CAB Abstracts, CAB Health, Chemical Abstracts, Current Contents/Clinical Medicine, EMBASE, Index Medicus, MEDLINE, PASCAL, Research Alert, and SCI Expanded. The Impact Factor is 0.827 and ranks third among the international andrology journals.

  12. Clinical Result in ICSI Method and Characterization of Acrosomal Integrity of Applicated Spermatozoa

    Czech Academy of Sciences Publication Activity Database

    Teplá, O.; Pěknicová, Jana; Mrázek, M.; Kočí, K.; Míka, J.; Hybnerová, L.; Jirmanová, J.; Chládek, David; Mayer, Z.

    Toronto : The Canadian Fertility and Andrology Society, American Society for Reproductive Medicine, 1999. s. S241. [Meeting of Society for Reproductive Medicine and Human Fertility and Andrology Society. 25.09.1999-30.09.1999, Toronto] R&D Projects: GA MZd IZ3911 Institutional research plan: CEZ:AV0Z5052915 Subject RIV: EB - Genetics ; Molecular Biology

  13. Acknowledgements

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    The Advisory and Editorial Boards of the Asian Journal of Andrology (AJA) wish to thank the following scientists for their unique contribution to AJA in reviewing the papers (including papers published and rejected) of this issue:

  14. Acknowledgements (continued)

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    The Advisory and Editorial Boards of the Asian Journal of Andrology (AJA) wish to thank the following scientists for their unique contribution to AJA in reviewing the papers (including papers published and rejected) of this issue:

  15. New therapies for relapsed castration-resistant prostate cancer based on peptide analogs of hypothalamic hormones

    Directory of Open Access Journals (Sweden)

    Andrew V Schally

    2015-01-01

    Full Text Available It is a pleasure to contribute our presentation at the International Prostate Forum of the Annual Meeting of the American Urological Association (AUA to this special issue of the Asian Journal of Andrology.

  16. TESTICULAR GROWTH DURING PUBERTY IN BOYS WITH AND WITHOUT A HISTORY OF CONGENITAL CRYPTORCHIDISM

    DEFF Research Database (Denmark)

    Sadov, Sergey; Koskenniemi, Jaakko J; Virtanen, Helena E;

    2016-01-01

    -control study. SETTING: Andrological Research Center, University of Turku. PARTICIPANTS: Altogether 119 boys participated: 51 cases with a history of congenital cryptorchidism and 65 controls fulfilled the inclusion criteria. INTERVENTION: None. MAIN OUTCOME MEASURES: Testicular volume by an orchidometer (m...

  17. Sperm preparation for fertilization

    OpenAIRE

    Gadella, B.M.

    2014-01-01

    Description This book contains 19 chapters that discuss theoretical and applied andrology for domestic, zoo and wild animals. Topics include semen and its constituents; sperm production and harvest; determinants of sperm morphology; sperm preparation for fertilization; practical aspects of semen cryopreservation; evaluation of semen in the andrology laboratory; genetic aspects of male reproduction; emerging techniques and future development of semen evaluation and handling and applied androlo...

  18. Prevalence, psychological impact, and risk factors of erectile dysfunction in patients with Peyronie’s disease: a retrospective analysis of 309 cases

    OpenAIRE

    Paulis G; Romano G; Paulis A

    2016-01-01

    Gianni Paulis,1,2 Gennaro Romano,3 Andrea Paulis4 1Department of Surgical Sciences, Andrology Center, Regina Apostolorum Hospital, Albano L., Italy; 2Department of Uro-Andrology, Peyronie’s Disease Care Center, Rome, Italy; 3Department of Urologic Oncology, Section of Avellino, Italian League Against Cancer, Avellino, Italy; 4Section of Psycho-Sexology, Peyronie’s Disease Care Center, Rome, Italy Abstract: Peyronie’s disease (PD) is a chronic inflammatory disease involv...

  19. Men's health is evolving

    Institute of Scientific and Technical Information of China (English)

    Run Wang; Wayne J. G

    2008-01-01

    @@ The Asian Journal of Andrology (AJA) is growing at a fast pace and becoming one of the leading journals in the field of andrology thanks to the leadership of Prof. Yi-Fei Wang, Editor-in-Chief of AJA, and the hard work of the AJA editorial staff. It was the spring of 2006 in Chicago when Ms. Dan-Qing Ren, Scientific Editor of the AJA, first approached us at the 31st American Society of Andrology (ASA) Annual Meeting regarding publishing a special issue on men's health. We were honored by the invitation to be guest editors for this special issue. We discussed potential topics with many of the contributors while Ms. Qin-Zhu Zheng, Editorial Director of the AJA worked out the details and met with us at the 32nd ASA Annual Meeting in Tampa, Florida. We are very pleased to present this issue of superior articles with contributions by internationally recognized authorities.

  20. The advantages of standardized evaluation of male infertility

    NARCIS (Netherlands)

    Pierik, F.H.; Ginneken, A.M. van; Dohle, G.R.; Vreeburg, J.T.M.; Weber, R.F.A.

    2000-01-01

    Healthcare can be improved by standardization and by evaluation of diagnostic methods and treatments. In the field of andrology, in which large patient numbers are required for the evaluation of diagnostic procedures and treatments, structured data collection and multicentre studies are especially w

  1. Unexplained Male infertility: diagnosis and Management

    Directory of Open Access Journals (Sweden)

    Alaa Hamada

    2012-10-01

    Full Text Available Unexplained male infertility is a diagnosis reserved for men in whom routine semen analyses results are within normal values and physical as well as endocrine abnormalities were ruled out. In addition to erectile problems and coital factors, immunologic causes and sperm dysfunction may contribute to such condition. New etiologies of unexplained male infertility include low level leukocytospermia and mitochondrial DNA polymerase gene polymorphism. Contemporary andrology may reveal cellular and sub-cellular sperm dysfunctions which may explain subfertility in such cases, thus aiding the clinician to direct the further work-up, diagnosis and counseling of the infertile male. The objective of this article is to highlight the concept of unexplained male infertility and focuses on the diagnosis and treatment of this condition in the era of modern andrology and assisted reproductive techniques. Extensive literature review was performed using the search engines: Pubmed, Science-direct, Ovid and Scopus.

  2. Effect of diets containing whole cottonseed on the quality of sheep semen=Efeito de dietas contendo caroço de algodão sobre a qualidade do sêmen de ovinos

    OpenAIRE

    Francisco Fernando Ramos de Carvalho; Carmen Iara Mazzoni Gonzalez; Maria das Graças Gomes Cunha; Adriana Trindade Soares

    2012-01-01

    This study evaluated the semen quality of Santa Ines sheep fed diets containing different levels of whole cottonseed (WCS). Twenty sheep were distributed into four groups that were given diets with 0; 20; 30; 40% of WCS. For this study the semen was collected by electroejaculation, and a monthly andrological examination was performed during nine months. The analyzed variables were: scrotal circumference (SC), appearance and color of the ejaculate, progressive motility (PM), vigor, mass moveme...

  3. Bone Cutting Forceps: A Safe Approach for Saving Strangulated Penis

    OpenAIRE

    Mohamed Ahmed Abd El Salam; Ahmed Gamal; Hossam Elenany

    2016-01-01

    Penile strangulation is considered a rare andrological emergency that may lead to a wide range of complications. Penile strangulation may be related to mental retardation in children or hypersexuality, abnormal sexual preferences in adults. This case report shows a 23-year-old male who presented to the emergency room with agonizing pain related to a metallic ring placed at the base of the penis for more than 8 hours during an attempt of masturbation. Removing this metallic ring and saving the...

  4. Surgical management of adolescent varicocele: Systematic review of the world literature

    Directory of Open Access Journals (Sweden)

    Omer A Raheem

    2013-01-01

    Full Text Available Historically, idiopathic varicocele is the most commonly diagnosed pre-pubertal andrological condition. The clinical presentation of varicocele may vary from dull and dragging unilateral or bilateral testicular pain to visible varicose veins lying over the hemiscrotum. Over the last decade, significant strides were made in managing symptomatic varicoceles, particularly minimal invasive procedures and surgeries. We sought to review the published literature in a systematic manner to gain an overview and streamline the presentations and main treatment modalities.

  5. Emerging treatments for premature ejaculation: focus on dapoxetine

    OpenAIRE

    Wayne JG Hellstrom

    2009-01-01

    Wayne JG HellstromChief, Section of Andrology, Department of Urology, Tulane University School of Medicine, New Orleans, LA, USAAbstract: Premature ejaculation (PE) is a common problem in men worldwide. It has a significant impact on affected men and their partners in terms of self-esteem, dissatisfaction with their sexual relationships, personal distress, and interpersonal difficulty. Psychological therapies may achieve short-term improvements, but there are limited data on the long-term suc...

  6. Prevalence Rate and Risk Factors of Depression in Outpatients with Premature Ejaculation

    OpenAIRE

    Xiansheng Zhang; Jingjing Gao; Jishuang Liu; Lei Xia; Jiajia Yang; Zongyao Hao; Jun Zhou; Chaozhao Liang

    2013-01-01

    The purpose of this study is to investigate the prevalence rate and risk factors of depression in outpatients who were diagnosed with PE. Therefore, between September 2009 and September 2011, 1801 outpatients at andrology clinics were enrolled and consented to participate in our survey by completed a verbal questionnaire. It included the following: (1) demographic data (e.g., age, body mass index), (2) PE duration, medical history, and sexual history, (3) self-estimated intravaginal ejaculato...

  7. The relationship between environmental exposures to phthalates and DNA damage in human sperm using the neutral comet assay.

    OpenAIRE

    Singh, Narendra P.; Silva, Manori J.; Barr, Dana B.; Brock, John W; Duty, Susan M; Ryan, Louise Marie; Herrick, Robert F.; Christiani, David C.; Hauser, Russ B.

    2003-01-01

    Phthalates are industrial chemicals widely used in many commercial applications. The general population is exposed to phthalates through consumer products as well as through diet and medical treatments. To determine whether environmental levels of phthalates are associated with altered DNA integrity in human sperm, we selected a population without identified sources of exposure to phthalates. One hundred sixty-eight subjects recruited from the Massachusetts General Hospital Andrology Laborato...

  8. Androgen deprivation therapy (castration therapy) and pedophilia: What’s new

    OpenAIRE

    Mauro Silvani; Nicola Mondaini; Alessandro Zucchi

    2015-01-01

    Andrology is a constantly evolving discipline, embracing social problems like pedophilia and its pharmacological treatment. With regard to chemical castration, the andrologist may perform an important role as part of a team of specialists. At present, no knowledge is available regarding hormonal, chromosomal or genetic alterations involved in pedophilia. International legislation primarily aims to defend childhood, but does not provide for compulsory treatment. We reviewed international liter...

  9. Formulation and clinical evaluation of silymarin pluronic-lecithin organogels for treatment of atopic dermatitis

    OpenAIRE

    Mady FM; Essa H; El-Ammawi T; Abdelkader H; Hussein AK

    2016-01-01

    Fatma M Mady,1,2 Hanaa Essa,2 Tarek El-Ammawi,3 Hamdy Abdelkader,2 Amal K Hussein2 1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Taibah University, Medina, Saudi Arabia; 2Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, Egypt; 3Department of Dermatology, STDs, and Andrology, Minia University Hospital, Minia, Egypt Abstract: Silymarin is a naturally occurring flavonoid drug; evidence from recent research has highlighted its use as ...

  10. Professor, member of the Academy of (Medical) Sciences, Igor Dmitrievich Kirpatovsky and his scientific heritage

    Science.gov (United States)

    Kaitova, Z.; Smirnova, E.; Protasov, A.

    2015-11-01

    Academician Igor Dmitrievich Kirpatovsky created a scientific school at the Department of Operative Surgery at the Russian People's Friendship University. Unique studies have been conducted in various areas of medicine and science: vascular and abdominal surgery; microsurgery; traumatology and orthopedics; clinical anatomy and relief anatomy; nervous and endocrine transplantation; andrology transplantation; experiments in the area of renal transplantation, small intestine and limb transplantation; transplantation immunology.

  11. The effect of low dose of vinclozolin on reproductive tract development and sperm parameters in CD1 outbred mice

    Czech Academy of Sciences Publication Activity Database

    Pěknicová, Jana; Elzeinová, Fatima; Nováková, Vendula; Buckiová, Daniela; Kubátová, Alena

    Barcelona : The American Society, 2009, s. 54-55 ISSN 0196-3635. [9th International Congress of Andrology. Barcelona (ES), 07.03.2009-10.03.2009] R&D Projects: GA MŠk(CZ) 1M06011; GA MŠk(CZ) 2B06151 Institutional research plan: CEZ:AV0Z50520701; CEZ:AV0Z50390703 Keywords : vinclozolin * spermatozoa * anti-androgen Subject RIV: DN - Health Impact of the Environment Quality

  12. Men with testosterone deficiency and a history of cardiovascular diseases benefit from long-term testosterone therapy: observational, real-life data from a registry study

    OpenAIRE

    Haider A.; Yassin A; Haider KS; Doros G; Saad F; Rosano GM

    2016-01-01

    Ahmad Haider,1 Aksam Yassin,2-4 Karim Sultan Haider,1 Gheorghe Doros,5 Farid Saad,4,6 Giuseppe MC Rosano7 1Private Urology Practice, Bremerhaven, 2Institute for Urology and Andrology, Segeberger Kliniken, Norderstedt, 3Department of Preventive Medicine, Men’s Health Program, Dresden International University, Dresden, Germany; 4Department of Urology, Gulf Medical University, Ajman, United Arab Emirates; 5Department for Epidemiology and Statistics, Boston University School of Public H...

  13. Factors influencing time course of pain after depot oil intramuscular injection of testosterone undecanoate

    OpenAIRE

    Sartorius, Gideon; Fennell, Carolyn; Spasevska, Sasa; Turner, Leo; Conway, Ann J.; Handelsman, David J

    2010-01-01

    Pain following depot intramuscular (IM) injection of oil vehicle-based drugs has been little studied. This study aimed to determine prospectively the prevalence, determinants, severity and functional consequences of pain during the week after IM injection of 1 000 mg testosterone undecanoate (TU) in a 4-mL castor oil vehicle. Androgen-deficient men receiving regular T replacement therapy at an academic andrology clinic were recruited to report pain scores using a coloured visual linear analog...

  14. Effect of diets containing whole cottonseed on the quality of sheep semen - doi: 10.4025/actascianimsci.v34i3.12963

    OpenAIRE

    Adriana Trindade Soares; Francisco Fernando Ramos de Carvalho; Carmen Iara Mazzoni Gonzalez; Maria das Graças Gomes

    2012-01-01

    This study evaluated the semen quality of Santa Ines sheep fed diets containing different levels of whole cottonseed (WCS). Twenty sheep were distributed into four groups that were given diets with 0; 20; 30; 40% of WCS. For this study the semen was collected by electroejaculation, and a monthly andrological examination was performed during nine months. The analyzed variables were: scrotal circumference (SC), appearance and color of the ejaculate, progressive motility (PM), vigor, mass moveme...

  15. Estrogen receptor β in male mice

    Czech Academy of Sciences Publication Activity Database

    Dostálová, Pavla; Děd, Lukáš; Dorosh, Andriy; Elzeinová, Fatima; Pěknicová, Jana

    Elsinore: International Society of Andrology, 2014. s. 48-48. [18th European Testis Workshop. 13.05.2014-17.05.2014, Elsinore] R&D Projects: GA MŠk(CZ) CZ1.05/1.1.00/02.0109; GA ČR GA14-05547S Institutional support: RVO:86652036 Keywords : estrogen receptor alpha * estrogen receptor beta * spermatozoa Subject RIV: EB - Genetics ; Molecular Biology

  16. AB025. Asian men’s sexual health: Korean perspective

    OpenAIRE

    Park, Kwangsung

    2016-01-01

    Sexual function is an important component of men’s health. The prevalence of erectile dysfunction (ED) in Korea has been reported as 18–36.6% whereas Asian data showed a wide range from 2% to 88%. In 2013, the Korean Society for Sexual Medicine and Andrology (KSSMA) developed the Korean Guideline of ED. Risk factors for ED included age, diabetes, hypertension, obesity, lack of exercise, dyslipidemia, smoking, depression, lower urinary tract symptoms, and pelvic surgery. This guideline showed ...

  17. Testosterone replacement alters the cell size in visceral fat but not in subcutaneous fat in hypogonadal aged male rats as a late-onset hypogonadism animal model

    OpenAIRE

    Abdelhamed A; Hisasue S; Shirai M; Matsushita K; Wakumoto Y; Tsujimura A; Tsukamoto T; Horie S

    2015-01-01

    Amr Abdelhamed,1,2 Shin-ichi Hisasue,1 Masato Shirai,3 Kazuhito Matsushita,1 Yoshiaki Wakumoto,1 Akira Tsujimura,1 Taiji Tsukamoto,4 Shigeo Horie1 1Department of Urology, Juntendo University, Graduate School of Medicine, Tokyo, Japan; 2Department of Dermatology, Venereology and Andrology, Sohag University, Graduate School of Medicine, Sohag, Egypt; 3Department of Urology, Juntendo University Urayasu Hospital, Urayasu, Japan; 4Department of Urology, School of Medicine, Sapporo Medical Universi...

  18. Impact of Cystic Fibrosis Transmembrane Regulator (CFTR) gene mutations on male infertility

    OpenAIRE

    Jlenia Elia; Rossella Mazzilli; Michele Delfino; Maria Piane; Cristina Bozzao; Vincenzo Spinosa; Luciana Chessa; Fernando Mazzilli

    2014-01-01

    Objective. The aim of this study was to evaluate the prevalence of most common mutations and intron 8 5T (IVS8-5T) polymorphism of CFTR gene in Italian: a) azoospermic males; b) non azoospermic subjects, male partners of infertile couples enrolled in assisted reproductive technology (ART) programs. Material and methods. We studied 242 subjects attending our Andrology Unit (44 azoospermic subjects and 198 non azoospermic subjects, male partners of infertile couples enrolled in ART programs). S...

  19. The effect of tetrabromobisphenol A on protamine content and DNA integrity in mouse sperm

    Czech Academy of Sciences Publication Activity Database

    Žatecká, Eva; Castillo, J.; Elzeinová, Fatima; Kubátová, Alena; Děd, Lukáš; Pěknicová, Jana; Oliva, R.

    Elsinore: International Society of Andrology, 2014. s. 47-47. [18th European Testis Workshop. 13.05.2014-17.05.2014, Elsinore] R&D Projects: GA MŠk(CZ) CZ1.05/1.1.00/02.0109; GA ČR(CZ) GAP503/12/1834 Keywords : tetrabromobisphenol A * protamine * DNA integrity * TUNEL assay Subject RIV: EB - Genetics ; Molecular Biology

  20. Correlation between penile cavernosal artery blood flow and retinal vascular findings in arteriogenic erectile dysfunction

    OpenAIRE

    Emarah, Ahmed

    2010-01-01

    Ahmed M Emarah1, Shawky M El-Haggar2, Ihab A Osman2, Abdel Wahab S Khafagy21Departments of Ophthalmology, 2Andrology and Sexology, Cairo University Hospital, EgyptObjectives: Arteriogenic erectile dysfunction (ED) is a target organ disease of atherosclerosis, and therefore might be a predictor of systemic atherosclerosis. Being systemic, it might be possible to evaluate the extent of atherosclerosis from retinal vascular findings. We investigated the possible correlation between penile cavern...

  1. THE ADDITION OF CAFFEINE IN EARLE’S BALANCED SALT SOLUTION MEDIA WITH WASHING UP METHOD INCREASE MEMBRANE INTEGRITY AND ACROSOMAL SPERM

    OpenAIRE

    B. K. Satriyasa; and A. N. Mahendra

    2014-01-01

    Background: caffeine, a methylxanthine derivate, appears to inhibit phosphodiesterase, thereby inhibiting the break down of cAMP and increasing its concentration inside cell. This study aims to assess the effect of caffeine addition in Earles’s Balanced Salt Solution (EBSS) on the increase in membrane integrity and acrosome reaction of spermatozoa using swim up method. Methods: This study was carried out at the Clinic of Sexology and Andrology, Sanglah Public Hospital at Denpasar Bali-Indones...

  2. Smoking, diabetes, blood hypertension: possible etiologic role for Peyronie’s disease? Analysis in 279 patients with a control group in Sicily

    Directory of Open Access Journals (Sweden)

    Carlo Pavone

    2015-03-01

    Full Text Available Objective: To assess the proportion of patients with Peyronie’s Disease (PD and the possible association with its potential risk factors in the general population of the central and western Sicily in our weekly andrological outpatient clinic. Materials and methods: We recruited a sample of 279 consecutive patients consulting our andrological outpatient clinic. Two arms were created: the first one composed by PD patients (men with symptoms suggestive for PD, the second one composed by patients with other andrological diseases (control arm. For each patient we evaluated the age, cigarette smoking, diabetes, blood hypertension and erectile function. In the PD arm we administered validated questionnaires to determine the erectile function status by the International Index of Erectile Function 5 (IIEF-5 and the pain status during erection by the Visual Analogue Scale (VAS. A univariate analysis was conducted using R software. Results: We enrolled 279 consecutive patients. The number of PD patients was 97 (34,7%. The univariate analysis showed a correlation between PD and cigarette smoking (p = 0.0242, blood hypertension (p < 0.001, erectile dysfunction (p < 0.001. No significant association was observed between diabetes and PD (p = 0.358. The median age of PD arm was 60 years and the median age of the control arm was 63,5 years; therefore the median age of PD arm resulted lower than the median age of the control arm (p = 0,031. Conclusions: Peyronie’s disease is more common than we might think; furthermore it can be diagnosed among young patients. According to our results, cigarette smoking and blood hypertension may be considered statically significant risk factors for developing PD. On the contrary diabetes seems not to be a risk factor for PD. According to our results PD should be sought also in young patients. Further studies are necessary to confirm that removing the indicated risk factors may reduce the incidence of PD.

  3. Functional testicular evaluation using PET/CT with 18F-fluorodeoxyglucose

    International Nuclear Information System (INIS)

    PET/CT using 18F-FDG is a well-established diagnostic examination in oncology, cardiology and neurology. The clinical significance of nontumoral testicular uptake of FDG is unknown. Functional testicular imaging may have important clinical applications in the diagnosis and prognosis of male infertility. The aim of this study was to determine the andrological value of a FDG PET/CT in analysing testicular function, by correlating the PET/CT data with the sperm parameters. Retrospective analysis of FDG PET/CT in 20 consecutive cancer patients without testicular pathology in whom two semen samples had been obtained for analysis before any chemotherapy. FDG PET/CT parameters were the mean standardized uptake value (SUVmean), used for measuring the intensity of uptake, and the functional testicular volume (FV). For statistical analysis, a Spearman's rank correlation test and a Mann-Whitney test were used. Of 20 patients (mean age 22 years), 18 had provided two sperm samples for cryopreservation. Sperm concentration was above 20 x 106/ml in 55% of the patients. The intensity of uptake and the FV were correlated with the total sperm count, the sperm concentration and motility (p < 0.05). The difference in SUVmean between the two testes showed an inverse correlation with sperm concentration (p = 0.036). Normospermic and oligospermic men had significant differences in: (1) mean SUVmean, (2) mean FV, and (3) the difference in intensity of uptake between the testes (p < 0.05). This is the first report on the andrological value of FDG PET/CT in analysing nontumoral testicular function. This pilot study showed a significant correlation between intensity of uptake of FDG and testicular FV with the main sperm parameters. PET/CT with FDG could become a useful new tool in assisted reproductive technologies and other andrological or urological applications. (orig.)

  4. Functional testicular evaluation using PET/CT with {sup 18}F-fluorodeoxyglucose

    Energy Technology Data Exchange (ETDEWEB)

    Dierickx, Lawrence Oliver; Zerdoud, Slimane; Filleron, Thomas; Brillouet, Severine [Institut Claudius Regaud, Service of Nuclear Medicine, Toulouse (France); Huyghe, Eric; Delauney, Boris; Bujan, Louis; Plante, Pierre [CHU Toulouse, Toulouse (France); Nogueira, Daniela; Montagut, Jacques [I.F.R.E.A.R.E.S., Toulouse (France); Courbon, Frederic [Institut Claudius Regaud, Service of Nuclear Medicine, Toulouse (France); CHU Toulouse, Toulouse (France)

    2012-01-15

    PET/CT using {sup 18}F-FDG is a well-established diagnostic examination in oncology, cardiology and neurology. The clinical significance of nontumoral testicular uptake of FDG is unknown. Functional testicular imaging may have important clinical applications in the diagnosis and prognosis of male infertility. The aim of this study was to determine the andrological value of a FDG PET/CT in analysing testicular function, by correlating the PET/CT data with the sperm parameters. Retrospective analysis of FDG PET/CT in 20 consecutive cancer patients without testicular pathology in whom two semen samples had been obtained for analysis before any chemotherapy. FDG PET/CT parameters were the mean standardized uptake value (SUVmean), used for measuring the intensity of uptake, and the functional testicular volume (FV). For statistical analysis, a Spearman's rank correlation test and a Mann-Whitney test were used. Of 20 patients (mean age 22 years), 18 had provided two sperm samples for cryopreservation. Sperm concentration was above 20 x 10{sup 6}/ml in 55% of the patients. The intensity of uptake and the FV were correlated with the total sperm count, the sperm concentration and motility (p < 0.05). The difference in SUVmean between the two testes showed an inverse correlation with sperm concentration (p = 0.036). Normospermic and oligospermic men had significant differences in: (1) mean SUVmean, (2) mean FV, and (3) the difference in intensity of uptake between the testes (p < 0.05). This is the first report on the andrological value of FDG PET/CT in analysing nontumoral testicular function. This pilot study showed a significant correlation between intensity of uptake of FDG and testicular FV with the main sperm parameters. PET/CT with FDG could become a useful new tool in assisted reproductive technologies and other andrological or urological applications. (orig.)

  5. Bone Cutting Forceps: A Safe Approach for Saving Strangulated Penis.

    Science.gov (United States)

    Abd El Salam, Mohamed Ahmed; Gamal, Ahmed; Elenany, Hossam

    2016-01-01

    Penile strangulation is considered a rare andrological emergency that may lead to a wide range of complications. Penile strangulation may be related to mental retardation in children or hypersexuality, abnormal sexual preferences in adults. This case report shows a 23-year-old male who presented to the emergency room with agonizing pain related to a metallic ring placed at the base of the penis for more than 8 hours during an attempt of masturbation. Removing this metallic ring and saving the patient's penis from gangrene without causing injury were very challenging. Patient was successfully managed and had an uneventful recovery. PMID:27239200

  6. Role of sperm surface proteins in reproduction

    Czech Academy of Sciences Publication Activity Database

    Jonáková, Věra; Postlerová, Pavla; Davidová, Nina; Tichá, M.; Pěknicová, Jana

    Barcelona : The American Society, 2009. s. 1-155 ISSN 0196-3635. [9th International Congress of Andrology. 07.03.2009-10.03.2009, Barcelona] R&D Projects: GA MŠk(CZ) 1M06011; GA ČR(CZ) GA303/06/0895; GA ČR(CZ) GD523/08/H064 Institutional research plan: CEZ:AV0Z50520701 Keywords : sperm surface protein * spermadhesin * reproduction Subject RIV: DN - Health Impact of the Environment Quality

  7. Efficacy and safety evaluation of pentoxifylline associated with other antioxidants in medical treatment of Peyronie's disease: a case-control study

    Directory of Open Access Journals (Sweden)

    Paulis G

    2015-12-01

    Full Text Available Gianni Paulis,1,2 Davide Barletta,3 Paolo Turchi,4 Antonio Vitarelli,5 Giuseppe Dachille,6 Andrea Fabiani,7 Romano Gennaro8 1Regina Apostolorum Hospital, Andrology Center, Albano L, 2Castelfidardo Medical Team, Peyronie's Disease Care Center, Rome, 3Department of Urology, Andrology Center, San Matteo Hospital, Pavia, 4Azienda ASL 4 Prato – Andrology Service, Prato, 5Department of Urology, University of Bari, 6Department of Urology, S Giacomo Hospital, Monopoli, Bari, 7Department of Surgery, Section of Urology and Andrology, Macerata, 8Department of Urologic Oncology, Section of Avellino, Italian League Against Cancer, Avellino, Italy Abstract: Peyronie's disease (PD is a chronic disorder involving the tunica albuginea surrounding the corpora cavernosa of the penis. A conservative treatment is indicated in the first stage of disease. The aim of this study was to assess the therapeutic impact and possible side effects of treatment with pentoxifylline (PTX in combination with other antioxidants in 307 patients with early-stage PD. Patients were subdivided into three groups: A, B, and C. Both groups, A and B, comprising of 206 patients, underwent treatment, whereas Group C was the control group (n=101. Treatment lasted 6 months and included the following: Group A: PTX 400 mg twice a day + propolis 600 mg/d + blueberry 160 mg/d + vitamin E 600 mg/d + diclofenac 4% gel twice/a day + PTX 100 mg via perilesional penile injection/every other week (12 injections in all; Group B: the same treatment as Group A except for the penile PTX injections. After the 6-month treatment course, we obtained the following results: actual mean decrease in plaque volume -46.9% and -24.8% in Group A and B, respectively (P<0.0001; mean curvature reduction -10.1° and -4.8°, respectively (P<0.0001; resolution of pain in 67.6% and 67.2% of cases, respectively (P=0.961; recovery of normal penile rigidity in 56.09% and 23.5% of cases, respectively (P=0.005. After 6 months

  8. La Estimulación Vibratoria del Pene (EVP), Alternativa Novedosa y no Invasiva para la Obtención de Semen en Primates y otras Especies Animales

    OpenAIRE

    Robin Poches-Franco

    2010-01-01

    A nivel mundial en diversas especies animales domésticas y silvestres, se lleva a cabo la colecta y evaluación de las características seminales con distintos objetivos, como son el conocimiento preliminar de la biología reproductiva (andrología), criopreservación de gametos, inseminación artificial entre otros. Para obtener semen se dispone de diversas técnicas; entre estos están; la electroeyaculación por sonda bipolar rectal o por estimulación directa del pene, la masturbación, la automastu...

  9. Insulin-like factor 3 serum levels in 135 normal men and 85 men with testicular disorders

    DEFF Research Database (Denmark)

    Bay, K; Hartung, S; Ivell, R;

    2005-01-01

    Insulin-like factor 3 (INSL3) serum levels were measured in 135 andrologically well-characterized normal men and 85 patients with testicular disorders to investigate how the hormone, which is a major secretory product of human Leydig cells, is related to testosterone (T), LH, and semen quality......, Klinefelter syndrome (n = 21), 0.12 (ND-0.78) ng/ml; men with hypogonadotropic hypogonadism and T substitution (n = 11), ND; and men with hypogonadotropic hypogonadism and human chorionic gonadotropin (hCG) treatment (n = 5), 0.36 (0.13-0.73) ng/ml. Before testicular biopsy, two infertile men had blood...

  10. Bone Cutting Forceps: A Safe Approach for Saving Strangulated Penis

    Directory of Open Access Journals (Sweden)

    Mohamed Ahmed Abd El Salam

    2016-01-01

    Full Text Available Penile strangulation is considered a rare andrological emergency that may lead to a wide range of complications. Penile strangulation may be related to mental retardation in children or hypersexuality, abnormal sexual preferences in adults. This case report shows a 23-year-old male who presented to the emergency room with agonizing pain related to a metallic ring placed at the base of the penis for more than 8 hours during an attempt of masturbation. Removing this metallic ring and saving the patient’s penis from gangrene without causing injury were very challenging. Patient was successfully managed and had an uneventful recovery.

  11. Evaluation of sexual maturity of young bulls from different breeds selected for post-weaning weight

    OpenAIRE

    Fabio Morato Monteiro; Letícia Zoccolaro Oliveira; Clara Slade Oliveira; Tatiane Almeida Drummond Tetzner; Maria eugênia zerlottu Mercadante; Renata Helena Branco; Joaquim Mansano Garcia

    2011-01-01

    Sperm traits of 243 young bulls from Caracu (n=62), Gir (n=23), Guzerá (n=59) and Nellore (n=99) breeds, with 20-25 months of age, from the Breeding Program of Estação Experimental de Zootecnia de Sertãozinho, were analyzed. On the day of breeding soundness evaluation animals were weighed, the scrotal circumference was measured and the semen was collected by electroejaculation. The sperm motility, vigor and morphology were assessed and the animals were classified according to the andrological...

  12. Modern views on the epidemiology, etiology and pathogenesis of gynecomastia

    Directory of Open Access Journals (Sweden)

    Yu. N. Yashina

    2014-12-01

    Full Text Available The review deals with one of the pressing andrological issues – gynecomastia, its etiology and pathogenesis. Based on the current epidemiological and experimental data, most common etiological factors of gynecomastia were investigated. A multiple-valued role of various causes of gynecomastia in several age-groups was revealed. Literature data show that gynecomastia may be a manifestation of various diseases: endocrine, genetic, systematic. As well as that, gynecomastia may occur in patients with oncological diseases. However, gynecomastia can be an iatrogenic complication. Currently, we continue to make insights to the problem of gynecomastia in order to be able to classify its etiological factors and determine its basic pathogenesis pathways.

  13. Prevalent false positives of azoospermia factor a (AZFa) microdeletions caused by single-nucleotide polymorphism rs72609647 in the sY84 screening of male infertility

    OpenAIRE

    Wu, De Qing; Chen, Guo-Wu; Yan, Tao-Fei; Wang, Hui; Liu, Yu-Ling; Li, Zheng; Duan, Shi-wei; Sun, Fei; Feng, Yun; Shi, Hui-Juan

    2011-01-01

    Multiplex polymerase chain reaction (PCR) has been widely used to detect Y-chromosome microdeletions, which is one of the major causes of male infertility. Both the European Academy of Andrology (EAA) and the European Molecular Genetics Quality Network (EMQN) have recommended the use of sY84 and sY86 markers for the detection of azoospermia factor a (AZFa) microdeletion during DNA testing for male infertility. In this study, a large-scale analysis of AZF microdeletion in a total of 630 Chines...

  14. Our experience in sperm morphology assessment

    Institute of Scientific and Technical Information of China (English)

    Julia Irene Ariagno; Susana Mercedes Curi; Patricia Chenlo; Herberto Ernesto Hector Repetto; Mercedes Norma Pugliese; Luis Alberto Palaoro; Melba Sardi; Gabriela Ruth Mendeluk

    2011-01-01

    @@ We read with great interest the article recently published by Menkeveld et al.1 as we have a double interest in sperm morphology assess-ment.The first one as a Clinical Andrology Laboratory(Laboratory of Male Fertility,Department of Clinical Biochemistry,Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina)attempting to give aluable diagnosis to our patients, and the second one as Sponsors of the External Quality Control for the Study of Human Semen in Argentina(Programa de Evaluación Externa de la Calidad(PEEC)de la Fundación Bioquimica Argentina2).

  15. Male sexual dysfunction and infertility associated with neurological disorders

    DEFF Research Database (Denmark)

    Fode, Mikkel; Krogh-Jespersen, Sheila; Brackett, Nancy L;

    2012-01-01

    options always require assisted reproductive techniques including intrauterine insemination or in vitro fertilization with or without intracytoplasmic sperm injection. The method of choice depends largely on the number of motile sperm in the ejaculate.Asian Journal of Andrology advance online publication...... in more severe cases. If these measures fail, surgical sperm retrieval can be attempted. Ejaculation with penile vibratory stimulation can be done by some spinal cord injured men and their partners at home, followed by in-home insemination if circumstances and sperm quality are adequate. The other...

  16. Consultation for Small-Sized Penis in the Egyptian Males: A Case Control Study.

    Science.gov (United States)

    Salama, Nader

    2016-05-01

    This study aimed to report penile dimensions in adult Egyptian males consulting for small-sized penis (SSP) and describe their demographics and andrological profile. A case control study was designed through retrospective data analysis of patients (n = 239) seeking advice for SSP and a control group (n = 59). This included sociodemographics, other andrological complaints, and penile dimensions (pendulous length [PL], penopubic or total length [TL], and circumference [CF]) at flaccid and erect states and the size of the prepubic fatty pad. The results reported that most patients were single, students, and smokers and had not completed a university education. Several patients reported falsely premature ejaculation (PE), penile curvature (PC), and small-sized testes. Most penile dimensions of the patients (mean, cm) were significantly lower than those of the controls, whether in flaccid (PL: 7.4 vs. 8.05, p = .008; CF: 8.7 vs. 8.98, p = .026) or erect state (PL: 11.8 vs. 13, p = .000; TL: 14.2 vs. 15, p = .000; CF: 11.3 vs. 11.8, p = .003). However, no patient presented with a pendulous penile length <4 cm in flaccid or <7 cm in erect state. In conclusion, Egyptian men consulting for SSP did not have true small organs, but their penile dimensions were slightly smaller than those of men without such complaint. The proper sexual education program is highly advisable in these situations to avoid the myths and misconceptions about sexuality. PMID:25563384

  17. [Funcion sparing surgery in uro-oncology: germ cell tumors of the testis].

    Science.gov (United States)

    Catanzaro, Mario; Piva, Luigi; Torelli, Tullio; Biasoni, Davide; Stagni, Silvia; Milani, Angelo; Necchi, Andrea; Giannatempo, Patrizia; Nicolai, A; Salvioni, Roberto

    2012-01-01

    Surgery in germ cell tumors of the testis (TGT) may result in andrological disorders, both after orchiectomy and after retroperitoneal lymphadenectomy (RPLND). Bilateral orchiectomy suppresses both testicular functions: exocrine and endocrine. In selected cases with bilateral TGT (metachronous/synchronous), or in the case of TGT in monorchid patients, partial orchiectomy (enucleation of the tumor) can preserve both functions with a low risk of relapse in residual testicular parenchyma, in the absence of intraepithelial neoplasia (TIN). In cases of TIN and normal testosterone levels (80%), the fertility is maintained in 50% of patients. In these cases the use of radiotherapy on the residual testicular parenchyma can prevent the future development of invasive cancer, though compromising the hormonal function. The RPLND (open or laparoscopic) can produce major side effects, such as retrograde ejaculation. Knowledge of the adrenergic fiber retroperitoneal neuroanatomy enables to implement a "nerve sparing" surgery with an almost total reduction of this serious side effect, but that option is only available in few centers of excellence. Semen cryopreservation has become a common practice performed before any treatment that might impact on the andrological function of patients. PMID:23371266

  18. Patient preference and satisfaction in erectile dysfunction therapy: a comparison of the three phosphodiesterase-5 inhibitors sildenafil, vardenafil and tadalafil

    Directory of Open Access Journals (Sweden)

    Amr Abdel Raheem

    2009-04-01

    Full Text Available Amr Abdel Raheem1, Philip Kell21St. Peter’s Andrology Department, The Institute of Urology, London, and Cairo University, Egypt; 2St. Peter’s Andrology Department, The Institute of Urology, London, UKAbstract: Erectile dysfunction (ED is a problem that may affect up to 52% of men between the ages of 40 and 70. It can be distressing because of its negative effect on self-esteem, quality of life, and interpersonal relationships. Oral phosphodiesterase-5 inhibitors (PDE5 inhibitors are now the first choice of treatment in ED. The availability of three (sildenafil citrate, tadalafil, and vardenafil well tolerated and effective oral PDE5 inhibitors gives treatment options for men with ED. Although the mechanism of action is the same for the three drugs, they differ in their pharmacokinetics. Several preference studies were conducted between the three PDE5 inhibitors but they were not free from bias. Because of the lack of overwhelming reliable data showing that one PDE5 inhibitor is superior to another, current opinion is that the individual patient should have the opportunity to test all three drugs and then select the one that best suits him and his partner.Keywords: erectile dysfunction, PDE5 inhibitors, patient preference

  19. Prevalence, psychological impact, and risk factors of erectile dysfunction in patients with Peyronie’s disease: a retrospective analysis of 309 cases

    Directory of Open Access Journals (Sweden)

    Paulis G

    2016-07-01

    Full Text Available Gianni Paulis,1,2 Gennaro Romano,3 Andrea Paulis4 1Department of Surgical Sciences, Andrology Center, Regina Apostolorum Hospital, Albano L., Italy; 2Department of Uro-Andrology, Peyronie’s Disease Care Center, Rome, Italy; 3Department of Urologic Oncology, Section of Avellino, Italian League Against Cancer, Avellino, Italy; 4Section of Psycho-Sexology, Peyronie’s Disease Care Center, Rome, Italy Abstract: Peyronie’s disease (PD is a chronic inflammatory disease involving the tunica albuginea of the penis. Erectile dysfunction (ED is a possible invalidating symptom of PD. The aim of this study was to evaluate the prevalence, psychological impact, and risk factors of ED in patients with PD. The study was conducted by carrying out a retrospective analysis of the clinical records of 309 patients with PD who visited our andrology clinic. All patients underwent the following tests: body mass index, common blood tests and hormone assays, questionnaire for erectile function assessment, dynamic penile color Doppler ultrasonography, imaging of the penis at maximum erection with photographic poses according to Kelâmi, psychosexual impact evaluation with PD Questionnaire (symptom bother score, evaluation of depression symptoms with the Patient Health Questionnaire-9, and evaluation of the intensity of penile pain with the pain intensity numeric rating scale. ED was observed in 37.5% of the cases. We divided the cases into two groups: group A (PD + ED, 116 cases, and group B (PD without ED, 193 cases. After multivariate analysis, we concluded that the following comorbidities are independent risk factors for ED: dyslipidemia, obesity, chronic prostatitis, benign prostatic hyperplasia, and autoimmune diseases. A depressive disorder was observed in 62.4%, and it was more frequent in patients with PD + ED (91.37% versus 45.07% group B. Sexual bother was greater in group A compared with group B (9.7 versus 7.6. Intensities of depressive symptoms and

  20. Novel Uses for the Anabolic Androgenic Steroids Nandrolone and Oxandrolone in the Management of Male Health.

    Science.gov (United States)

    Wu, Christopher; Kovac, Jason R

    2016-10-01

    There has recently been renewed interest in novel clinical applications of the anabolic-androgenic steroid (AAS) testosterone and its synthetic derivatives, particularly given with the rising popularity of testosterone supplementation therapy (TST) for the treatment of male hypogonadism. In this manuscript, we provide a brief review of the history of AAS and discuss clinical applications of two of the more well-known AAS: nandrolone and oxandrolone. Both agents exhibit favorable myotrophic/androgenic ratios and have been investigated for effectiveness in numerous disease states. We also provide a brief synopsis of selective androgen receptor modulators (SARMs) and postulate how these orally active, non-aromatizing, tissue-selective agents might be used in contemporary andrology. Currently, the applications of testosterone alternatives in hypogonadism are limited. However, it is tempting to speculate that these agents may one day become accepted as alternatives, or adjuncts, to the treatment of male hypogonadism. PMID:27535042

  1. Sexual (Dys)function after Urethroplasty

    Science.gov (United States)

    2016-01-01

    There is a paucity of published literature on the andrological consequences of urethral repair. Until recently authors have focused mainly on technical aspects and objective results. Reported outcomes of urethral reconstruction surgery have traditionally focused only on urodynamic parameters such as flow rates. Patient reported outcome measures have largely been neglected and there is a scarcity of well conducted systematic studies on the subject. For these reasons whether the different components of sexual life are more or less affected by different types of urethral reconstruction remains largely unknown. In an attempt to clarify the available scientific evidence, the authors make a critical review of available literature, systematizing it by sexual domain and study type. Brief pathophysiological correlations are discussed. PMID:27051420

  2. The Effect of Sperm Morphology and Sire Fertility on Calving Rate of Finnish Ayrshire AI Bulls.

    Science.gov (United States)

    Attia, S; Katila, T; Andersson, M

    2016-02-01

    Good-quality semen is a prerequisite for successful and profitable artificial insemination (AI) of modern dairy cattle. Fertility of the bulls is evaluated with andrological examinations and semen analyses, such as morphology. However, little attention has been paid to the inheritance of bull fertility. In this study, we correlated sperm morphology, birth year and station of 695 AI bulls with calving rate (CR). Sperm morphology was clearly associated with CR underlining the usefulness of morphological examination in the assessment of fertility. The correlation between the proportion of normal spermatozoa and CR was significant (p sires to study the inheritance of fertility. Sire's CR did not correlate with the CR of the sons (p = 0.218). This result indicates that at least when sires of acceptable CR are used to produce sons for use in AI the inheritance of CR is not significantly correlated. PMID:26660630

  3. Effect of diets containing whole cottonseed on the quality of sheep semen - doi: 10.4025/actascianimsci.v34i3.12963

    Directory of Open Access Journals (Sweden)

    Adriana Trindade Soares

    2012-05-01

    Full Text Available This study evaluated the semen quality of Santa Ines sheep fed diets containing different levels of whole cottonseed (WCS. Twenty sheep were distributed into four groups that were given diets with 0; 20; 30; 40% of WCS. For this study the semen was collected by electroejaculation, and a monthly andrological examination was performed during nine months. The analyzed variables were: scrotal circumference (SC, appearance and color of the ejaculate, progressive motility (PM, vigor, mass movement (MM, total sperm concentration (spzX109, sperm morphology (SM and blood hematocrit. The SC had no difference among diets, with mean 31.83 cm. The animals fed diets with WCS, presented mean intake of 9.16 mg gossypol kg BW, and were prone to present greenish semen, and appearance ranging from thin creamy to watery. The PM decreased linearly (p

  4. Semen quality and reproductive hormones before orchiectomy in men with testicular cancer

    DEFF Research Database (Denmark)

    Petersen, P M; Skakkebaek, N E; Vistisen, K; Rørth, M; Giwercman, A

    1999-01-01

    PURPOSE: To obtain information about preorchiectomy gonadal function in patients with testicular germ cell cancer to improve the clinical management of fertility and other andrologic aspects in these men. PATIENTS AND METHODS: In group 1, a group of 83 consecutive patients with testicular germ cell......-existing Leydig cell dysfunction is present in men with testicular cancer could not be answered in this study because the tumor seems to have a direct effect on the Leydig cells. Men with testicular cancer had low LH values as compared with controls. We speculate that increased intratesticular level of hCG also...... in men without measurable serum hCG may play a role by exerting LH-like effects on the Leydig cells, causing increased testosterone and estrogen levels and low LH values in the blood....

  5. Sexual medicine disparities between Asia and North America: commentary on male sexual dysfunction in Asia

    Institute of Scientific and Technical Information of China (English)

    Benjamin F Katz; Doron S Stember; Harris M Nagler

    2011-01-01

    @@ In a recently published article in Asian Journal of Andrology, Ho et al.1 examine prevalence,attitudes, and treatment patterns related to sexual dysfunction in Asia and contrast them with those of Western society.They highlight the relative paucity of data with respect to erectile dysfunction (ED), premature ejaculation, and hypogonadism in the Asian population.Although the authors make a commendable attempt to characterize sexual dysfunction in Asia, there are multiple factors that complicate interpretation of published prevalence rates.Confounding factors affecting interpretation of these studies include the methodology of identification of the studied cohorts, ages of study participants, survey response rates, definitions of ED, and strategies and lengths of time for data collection.

  6. Sperm Selection in ART

    Directory of Open Access Journals (Sweden)

    Montag M

    2012-01-01

    Full Text Available Selection of sperm is a crucial part in assisted reproductive treament (ART. Sperm preparation methods do mainly differentiate according to sperm motility and are indispensable for therapies like intrauterine insemination, in-vitro fertilization (IVF and intracytoplasmic sperm injection (ICSI. Although in the beginning of the era of ICSI andrology was thought to play a minor role, ICSI has offered new options by correlating the treatment outcome to parameters of the individual applied spermatozoon. Hence the possibility for selecting spermatozoa has shifted from parameters which characterize the entire sperm cohort to a single-sperm specific assessment technology. Consequently, sperm selection is a topic which is intensively discussed nowadays. This article gives a comprehensive overview of the technologies which can be applied today and give a prospective on future techniques.

  7. [Painful ejaculation: a review].

    Science.gov (United States)

    Pescatori, E S; Pirozzi Farina, Furio

    2009-01-01

    Pain at ejaculation/orgasm perceived in perineum, urethra and/or urethral meatus, has a profound impact on the quality of life of the affected man. Although underestimated, this condition is reported to have a 1-9.7% prevalence over the general population. METHODS. Structured review of the relevant available literature. RESULTS. Among the main causes of pain experienced at ejaculation/orgasm are: prostatevesicular causes (LUTS/BPH, prostatitis, ejaculatory duct obstruction, vesicular stone), postsurgical causes (radical prostatectomy, inguinal hernioplasty), pharmacologic causes (antidepressants), psychogenic causes (psychosexual conflicts, sexual abuse), rare causes. For these pathologies, diagnostic and therapeutic strategies have been proposed. CONCLUSIONS. Ejaculatory pain is associated with a high level of personal distress, and represents a possible request for help within the andrologic/urologic area. Each field specialist should be competent in correctly interpreting every single case, in order to manage it appropriately. PMID:21086282

  8. Recovery, isolation, identification, and preparation of spermatozoa from human testis.

    Science.gov (United States)

    Muller, Charles H; Pagel, Erin R

    2013-01-01

    In some cases, human spermatozoa to be used for in vitro fertilization are processed from testicular or epididymal biopsies collected in the clinic or operating room. An appropriately equipped Andrology or Embryology Laboratory is required. Sterility must be maintained at all stages from collection and transport to identification and processing to insemination or cryopreservation. The technologist must be able to properly process and identify spermatozoa from aspirates, seminiferous tubules or pieces of testicular tissue. Recovery of undamaged spermatozoa from tubules or tissue requires mincing, squeezing, or vortexing the tissue, usually without the need of enzymatic digestion. A motility stimulant such as Pentoxifylline is commonly used to calculate the number of functionally competent spermatozoa. After recovery, spermatozoa may be used immediately for IVF-ICSI, incubated overnight prior to IVF-ICSI, or cryopreserved for future use. Methods for identifying, purifying, and determining the number and motility of spermatozoa during these processes are presented. PMID:22992917

  9. The current understanding of the treatment chronic non-bacterial prostatitis with inflammatory component

    Directory of Open Access Journals (Sweden)

    Yu. Yu. Vinnik

    2015-01-01

    Full Text Available A literature review is dedicated to one of the most urgent problems of modern andrology – the treatment of chronic non-bacterial prostatitis (CP with inflammatory component. Over the past decades, despite numerous methods of prevention and treatment offered by the Russian and foreign urologists, the incidence of CP has been steadily progressing. Treatment of patients with CP should be comprehensive and be sure to include the effects on all the links in the pathogenesis of the disease. It is different depending on the age of the patient and the presence and nature of CP manifestations, including changes in mental status, especially disease progression, stage and phase inflammatory activity in the prostate, the degree of involvement in the disease process nearby organs, immune status and other factors. The proposed scientific review covers the basic techniques of therapeutic effect on patients with CP. Given in article data allows a more rational approach to the treatment of these patients.

  10. A subfertile patient diagnosed with testicular carcinoma in situ by immunocytological staining for AP-2gamma in semen samples

    DEFF Research Database (Denmark)

    Hoei-Hansen, C E; Rajpert-De Meyts, E; Carlsen, E;

    2005-01-01

    . CIS diagnosis is presently only possible by a surgical biopsy of the testis. Immunocytological staining for transcription factor activator protein (AP-2gamma), previously identified as a marker for neoplastic germ cells, was performed in centrifuged samples of ejaculates obtained from 104 andrological...... patients, including patients with testicular cancer and subfertility. Cells positive for AP-2gamma were found only in semen samples from patients diagnosed a priori with testicular neoplasms and, surprisingly, in a 23 year old control subject with oligozoospermia and no symptoms of a germ cell tumour......, simple method based on immunocytological staining of a semen sample for AP-2gamma, a novel marker for CIS. The value of this method for diagnostic use in the clinic requires further careful validation in a large series of patients and controls, but the preliminary results are promising....

  11. Current approaches for detection of carcinoma in situ testis

    DEFF Research Database (Denmark)

    Hoei-Hansen, Christina E; Olesen, Inge A; Jørgensen, Niels;

    2007-01-01

    least one solid immunohistochemical marker, for example PLAP, OCT-3/4 or AP-2gamma. Determination of who should be offered testicular biopsies is based on clinical and ultrasonic examination along with the evaluation of risk factors. A surgical biopsy is an invasive procedure with potential......-malignant changes, especially in males with additional risk factors. Promising results have recently been obtained with a novel noninvasive detection method based on immunocytological AP-2gamma-staining of CIS cells in semen. This method could be a supporting method in andrology centres where careful follow-up is...... possible. In conclusion, one difficulty is to determine in which males CIS should be suspected; secondly, there does not as yet exist an optimal noninvasive method of diagnosis that is more acceptable than an open surgical biopsy....

  12. Genital diseases awareness in young male students: Is information necessary to protect them?

    Directory of Open Access Journals (Sweden)

    Nicola Mondaini

    2013-04-01

    Full Text Available Introduction: Few studies on the prevalence of male sexual diseases are currently available due to difficult application of observational studies or andrological disease prevention campaigns on large series of apparently healthy subjects. The medical check-up linked to compulsory military service represented in Italy a valid tool for epidemiological and observational study for 18 year old boys from 1861 to 2004. The stopping of compulsory military service and its related medical check-up could have determined an important social impact in terms of a lower level of attention and care on male genital/sexual diseases. The aim of the present observational study was to check the prevalence of genital/ sexual diseases among young male high-school students and promote an alternative campaign of information among young students. Methods: A prospective observational analytical study on young male students was conducted by 6 urological centres. Genital and sexually transmitted diseases were presented with slides to students in a general assembly. Some students were then counselled and filled out a short questionnaire on their lifestyle. Results: 12,535 students (10,432 males-83.6% followed the presentation. and 4,897 males (46.7% decided to be checked-up by the urologist and out of them 1554 (31.7% presented relevant andrological diseases. Five-hundred students completed the questionnaire concerning their lifestyle. Many of them had not yet experienced condom use during sexual intercourse (27.8%. Drug abuse was reported by 39.6% of subjects and alcohol consumption in 80.8% of them. Conclusions: These data suggest the need for a national information campaign on male sexual disorders to promote sexual health.

  13. Efficacy and safety of tamsulosin for the treatment of benign prostatic hyperplasia: a meta analysis

    Institute of Scientific and Technical Information of China (English)

    REN Rui-min; KOU Min; LAN Xiao-xu

    2010-01-01

    Background Pharmacological therapy has been considered as the first-line treatment for patients with uncomplicated benign prostatic hyperplasia (BPH). The aim of this study was to evaluate the efficacy and safety of tamsulosin compared with a placebo for treating BPH. Methods The randomized placebo-controlled trials (RCT) of tamsulosin for the treatment of BPH from all over the world were searched. PubMed, Ovid, ScienceDirect, EBSCO, CBM, and CNKI were searched, as well as a manual search of four Chinese journals: Chinese Journal of Andrology, National Journal of Andrology, Chinese Journal of Urology, and Journal of Clinical Urology was also performed. Two reviewers independently screened the studies for eligibility, evaluated the quality and extracted the data from the eligible studies, with confirmation by cross-checking. Divergences of opinions were settled by discussion. Meta-analysis was processed by Rev Man 5.0 software, fail-safe number was performed by SAS8.0 software. Results Seven RCTs involving 2455 men met the inclusion criteria. The basic characteristics of patients were comparable in all the studies. Comparing three common criteria: international prostate symptom score (IPSS)/Boyarsky symptom score, maximum flow rate (MFR), quality of life (QOL), tamsulosin was better than placebo at improving IPSS and MFR, with no significant difference in the QOL. Adverse events of tamsulosin also showed no significant difference from the placebo group (Z=1.62, P=0.10, OR=1.22, 95% CI 0.96-1.54).Conclusions Tamsulosin is better than placebo at improving IPSS and MFR. Adverse events of tamsuloisn show no significant difference compared with placebo. More high quality trials with larger samples and longer follow-up are proposed.

  14. Men with testosterone deficiency and a history of cardiovascular diseases benefit from long-term testosterone therapy: observational, real-life data from a registry study

    Directory of Open Access Journals (Sweden)

    Haider A

    2016-06-01

    Full Text Available Ahmad Haider,1 Aksam Yassin,2-4 Karim Sultan Haider,1 Gheorghe Doros,5 Farid Saad,4,6 Giuseppe MC Rosano7 1Private Urology Practice, Bremerhaven, 2Institute for Urology and Andrology, Segeberger Kliniken, Norderstedt, 3Department of Preventive Medicine, Men’s Health Program, Dresden International University, Dresden, Germany; 4Department of Urology, Gulf Medical University, Ajman, United Arab Emirates; 5Department for Epidemiology and Statistics, Boston University School of Public Health, Boston, MA, USA; 6Global Medical Affairs Andrology, Bayer Pharma AG, Berlin, Germany; 7Department of Cardiology, Centre for Clinical and Basic Science, San Raffaele-Roma, Rome, Italy Background/objectives: Long-term testosterone therapy (TTh in men with hypogonadism has been shown to improve all components of the metabolic syndrome. In this study, we investigated the effects of long-term TTh up to 8 years in hypogonadal men with a history of cardiovascular disease (CVD.Patients and methods: In two urological clinics observational registries, we identified 77 hypogonadal men receiving TTh who also had a history of CVD. The effects of TTh on anthropometric and metabolic parameters were investigated for a maximum duration of 8 years. Any occurrence of major adverse cardiovascular events was reported. All men received long-acting injections of testosterone undecanoate at 3-monthly intervals.Results: In 77 hypogonadal men with a history of CVD who received TTh, we observed a significant weight loss and a decrease in waist circumference and body mass index. Mean weight decreased from 114±13 kg to 91±9 kg, change from baseline: −24±1 kg and –20.2%±0.5%. Waist circumference decreased from 112±8 cm to 99±6 cm, change from baseline: −13±0.3 cm. Body mass index decreased from 37±4 to 29±3, change from baseline: −8±0.2 kg/m2. Cardiometabolic parameters such as lipid pattern, glycemic control, blood pressure, heart rate, and pulse pressure all

  15. Sperm preparation for ART

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    Schill Wolf-Bernhard

    2003-11-01

    Full Text Available Abstract The onset of clinical assisted reproduction, a quarter of a century ago, required the isolation of motile spermatozoa. As the indication of assisted reproduction shifted from mere gynaecological indications to andrological indications during the years, this urged andrological research to understand the physiology of male germ cell better and develop more sophisticated techniques to separate functional spermatozoa from those that are immotile, have poor morphology or are not capable to fertilize oocytes. Initially, starting from simple washing of spermatozoa, separation techniques, based on different principles like migration, filtration or density gradient centrifugation evolved. The most simple and cheapest is the conventional swim-up procedure. A more sophisticated and most gentle migration method is migration-sedimentation. However, its yield is relatively small and the technique is therefore normally only limited to ejaculates with a high number of motile spermatozoa. Recently, however, the method was also successfully used to isolate spermatozoa for intracytoplasmic sperm injection (ICSI. Sperm separation methods that yield a higher number of motile spermatozoa are glass wool filtration or density gradient centrifugation with different media. Since Percoll® as a density medium was removed from the market in 1996 for clinical use in the human because of its risk of contamination with endotoxins, other media like IxaPrep®, Nycodenz, SilSelect®, PureSperm® or Isolate® were developed in order to replace Percoll®. Today, an array of different methods is available and the selection depends on the quality of the ejaculates, which also includes production of reactive oxygen species (ROS by spermatozoa and leukocytes. Ejaculates with ROS production should not be separated by means of conventional swim-up, as this can severely damage the spermatozoa. In order to protect the male germ cells from the influence of ROS and to stimulate

  16. Behavioural and seminal characteristics of Santa Ines rams subjected to successive semen collections in the Amazonian region

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    Luiz Fernando S. Rodrigues

    2012-10-01

    Full Text Available The objective of this study was to evaluate the reproductive performance of Santa Ines rams subjected to successive semen collections in an Amazonian climate. Four rams were subjected to successive ejaculations during a maximum period of three hours. This procedure was repeated three times at 15-day intervals. Sexual and behavioural (libido and andrological (testicular and seminal assessments were performed. A total of 81 ejaculates were collected. Libido and semen vigour, volume, appearance and concentration decreased as the ejaculation frequency increased (P<0.05 and sperm motility showed a decreasing trend (P=0.06. The seminal pH increased over the sequence of collections (P<0.05. The only significant differences observed between individual rams were the variable scrotal circumference and the percentages of live sperm and sperm abnormalities (P<0.05. All the parameters of the first ejaculation were within the normal range for this species, which suggests that the local climatic conditions (high temperature and humidity did not affect the behavioural, testicular or seminal parameters of experimental rams. Our findings indicate that the reproductive performance of Santa Ines rams could be affected by the intensification of ejaculation frequency; however, individual male variation needs to be taken into consideration.

  17. Comparative study of dichlorodiphenyldichloroethylene in blood and semen of two young male populations: lack of relationship to infertility, but evidence of high exposure of the mothers.

    Science.gov (United States)

    Charlier, Corinne J; Foidart, Jean-Michel

    2005-01-01

    The purpose of the study was to investigate the possible effect of an environmental organochlorine, dichlorodiphenyldichloroethylene (p,p'-DDE), on male fertility assessed by main sperm variables, conducted through a case-control study on young men attending the andrology laboratory in the context of infertility investigation in the couple. Blood and semen samples were obtained from 73 young men considered as fertile based on semen analysis (controls) and 82 classified as subfertile or unfertile (cases). Standard clinical analysis of semen was performed and identification and quantification of p,p'-DDE in serum and in seminal plasma were done by gas chromatography. No p,p'-DDE was detected in the seminal plasma of either group. Blood concentration of p,p'-DDE in both groups was very low and did not differ between cases and controls; however, blood samples were obtained from 23 mothers in the control group, and from 19 in the case group, and p,p'-DDE serum level was significantly higher in the mothers of subfertile men. These data suggest that male infertility could be associated with exposure of the mothers to p,p'-DDE with deleterious effects restricted to intra-uterine life and thus undetected in blood or seminal plasma of subfertile men. PMID:15907656

  18. Possibilities of technologies that replace in-patient facilities in uroandrology

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    T. I. Derevyanko

    2015-01-01

    Full Text Available One of the main directions in improvement of medical service became invasion of stationary substitute technologies. In Stavropol since 2007 has been organized the Men, s health protection service based on Regional clinical specialized uroandrological center. In uroandrological short stay surgical department successfully provides treatment in all forms of male genital in children and adult pathology with using minimally invasive methodics in short stay conditions and absence postsurgical complications. The operation rooms are staffed with all necessary equipment for carry out activities in full volume. All patients treated in urological department had sorted by anaesthesiological and somatic criterias.The main strategical directions are male reproductive health, pediatric urology-andrology, oncouroandrology. Human resources, high technology staff and intelligent work organization are fundamental for modern stationary substitute service. Human resource conception is urologist-andrologist – urologist – surgeon with laparoscopic, transurethral, microsurgery, reconstructive and plastic technique with endocrinology and psychiatric skills.Work indicators of medical center tells about high effectiveness and possibility of release profile urological beds for “big” surgical help and transfer male genital surgery on stationary substitute technologies.

  19. Premature ejaculation and coping strategy%早泄问题及应对策略

    Institute of Scientific and Technical Information of China (English)

    安新涛

    2015-01-01

    探讨早泄的定义、分类分型、常见病因、检查手段以及治疗方法,使男科医师对早泄有整体系统的认识。帮助患者寻找病因,提出可根据不同类型的患者,尝试多种诸如药物、心理、行为、物理治疗方式等,同时进行性生活教育与指导,满足早泄患者咨询、提高性生活质量等不同需求。%To explore the definition ,classification ,common causes ,examina‐tional means and treatment of premature ejaculation makes andrology physicians have a whole and systemic understanding of premature ejaculation .Author helps patients look for cause of premature ejaculation ,puts forward that physicians should try a variety of treatments such as medicine ,psychological ,behavioral , physical therapy etc .according to different types of patients ,and at the same time give sexual life education and guidance to meet patient’s counseling and improve quality of sexual life .

  20. Prevalence Rate and Risk Factors of Depression in Outpatients with Premature Ejaculation

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    Xiansheng Zhang

    2013-01-01

    Full Text Available The purpose of this study is to investigate the prevalence rate and risk factors of depression in outpatients who were diagnosed with PE. Therefore, between September 2009 and September 2011, 1801 outpatients at andrology clinics were enrolled and consented to participate in our survey by completed a verbal questionnaire. It included the following: (1 demographic data (e.g., age, body mass index, (2 PE duration, medical history, and sexual history, (3 self-estimated intravaginal ejaculatory latency times, (4 the Zung Self-rating Depression Scale (SDS, and (5 the National Institute of Health Chronic Prostatitis Symptom Index (NIH-CPSI and (6 the International Index of Erectile Function (IIEF-5. The results showed that a total of 1,206 patients were diagnosed with PE. The prevalence rate of depression in these PE patients was 26.78%. Depression was associated with PE duration, NIH-CPSI score, and IIEF-5 score. Risk factors for depression specifically included PE durations for 13–24, 25–60, or ≥61 months, CPSI scores of 15–30 or ≥31, and IIEF-5 scores <22. These findings suggested that several associated factors (PE duration, CPSI scores, and IIEF-5 scores were the risk factors of depression in men with PE.

  1. Efeitos do trimetilaminoetano (TES e ringer lactato em sêmen de macacos-aranha mantidos em cativeiro ( Ateles paniscus e A. marginatus

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    K.S.M. Silva

    2013-06-01

    Full Text Available The performances of the diluents TES and CEBRAN II were compared as cryopreservatives of semen from non human primates of the genus Ateles. The experiment was carried out using one Ateles marginatus and two Ateles paniscus specimens, males and adults, maintained in the same captivity conditions at the National Center of Primates (CENP-SVS/MS. The animals were subjected to clinical and andrological examinations - testicular biometry - before the semen collection by eletroejaculation. Evaluations of motility and forward movement in the fresh semen were made. Semen were made dilution was made with the diluents TES and CEBRAN II. The ejaculates were diluted with the diluents (2:1proportion, packed in 0.25mL plastic straws and cryopreserved in liquid nitrogen. After thawing, the packed ejaculates were appraised in thermo resistance test (TTR. The averages of volume and concentration were, respectively, 1.94mL (0.83 and 3,020,000 sptz/mL (275.97. The pH 8 and seminal coagulation were observed in all samples. The results suggest that the TES diluent presents better efficiency in the preservation of Ateles semen than CEBRAN II.

  2. The possibility of hyperbaric oxygenation in the correction of the secretory impaired fertility in men

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    S. V. Fesenko

    2015-02-01

    Full Text Available The infertility problem during a marriage affects demographic indicators significantly and has not only medical and biological but important social significance as well. In Russia, about 20 % of married couples remain infertile. With that, in half of cases this is caused with pathological changes in male reproductive system. Until now, a comprehensive andrologic examination is not capable of finding out the reason of pathospermia in 40–72 % of cases of male infertility and, as a result, of assigning the appropriate etiotropic treatment. A comparative dynamic study of spermograms of 107 patients with idiopathic pathozoospermia depending on various types of treatment has been held immediately, 1 month, and 2 months after completion of the therapy course. It has been determined that significantly greater and sustained improvement in quality and quantity of ejaculate is achieved in 1 month as compared to monotherapy with L-carnitine in combination with hyperbaric oxygenation by eliminating the effects of hypoxia and oxidativestress, and the effect is maintained during the whole term of observation.

  3. Pilot Study on the Effect of Botanical Medicine (Tribulus terrestris) on Serum Testosterone Level and Erectile Function in Aging Males With Partial Androgen Deficiency (PADAM).

    Science.gov (United States)

    Roaiah, Mohamed Farid; El Khayat, Yasser Ibrahim; GamalEl Din, Sameh Fayek; Abd El Salam, Mohamed Ahmed

    2016-05-18

    This study was conducted on 30 consecutive male patients presenting to Kasr-Al Ainy Andrology outpatient clinic complaining of manifestations of partial androgen deficiency in aging males (PADAM). In this study (750 mg/day) of Tribulus terrestris in 3 divided doses, each of 250 mg, as an endogenous testosterone enhancer had been tried for a duration of 3 months and the evaluation of its effect had been monitored for each patient concerning its effect on serum testosterone (total and free) and luteinizing hormone (LH), as well as its impact on erectile function, which was evaluated by the International Index of Erectile Function-5 (IIEF-5) questionnaire for those patients. Results showed a statistically significant difference in the level of testosterone (total and free) and IIEF-5, but no statistically significant difference in the level of LH before and after treatment. Also, the study showed statistically significant correlation between testosterone (total and free) and IIEF-5, but no statistically significant correlation between the level of LH and the IIEF-5 before and after treatment. PMID:25849625

  4. New Approaches to Boar Semen Evaluation, Processing and Improvement.

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    Sutovsky, P

    2015-07-01

    The improvement of boar reproductive performance may be the next frontier in reproductive management of swine herd in Unites States, facilitated by better understanding of boar sperm function and by the introduction of new advanced instrumentation in the andrology field. Objective single ejaculate evaluation and individual boar fertility prediction may be possible by introducing automated flow cytometric semen analysis with vital stains (e.g. acrosomal integrity and mito-potential), DNA fragmentation analysis and biomarkers (ubiquitin, PAWP, ALOX15, aggresome) associated with normal or defective sperm phenotypes. Measurement of sperm-produced reactive oxygen species (ROS) is a helpful indicator of normal semen sample. Semen ROS levels could be managed by the addition of ROS-scavenging antioxidants. Alternative energy regeneration substrates and sperm stimulants such as inorganic pyrophosphate and caffeine could increase sperm lifespan in extended semen and within the female reproductive system. Such technology could be combined with timed sperm release in the female reproductive system after artificial insemination. Sperm phenotype analysis by the image-based flow cytometry will go hand in hand with the advancement of swine genomics, linking aberrant sperm phenotype to the fertility influencing gene polymorphisms. Finally, poor-quality ejaculates could be rescued and acceptable ejaculates improved by semen purification methods such as the nanoparticle-based semen purification and magnetic-activated sperm sorting. Altogether, these scientific and technological advances could benefit swine industry, provided that the challenges of new technology adoption, dissemination and cost reduction are met. PMID:26174914

  5. Impact of long-term and short-term therapies on seminal parameters

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    Jlenia Elia

    2013-04-01

    Full Text Available Aim: The aim of this work was: i to evaluate the prevalence of male partners of subfertile couples being treated with long/short term therapies for non andrological diseases; ii to study their seminal profile for the possible effects of their treatments on spermatogenesis and/or epididymal maturation. Methods: The study group was made up of 723 subjects, aged between 25 and 47 years. Semen analysis was performed according to World Health Organization (WHO guidelines (1999. The Superimposed Image Analysis System (SIAS, which is based on the computerized superimposition of spermatozoa images, was used to assess sperm motility parameters. Results: The prevalence of subjects taking pharmacological treatments was 22.7% (164/723. The prevalence was 3.7% (27/723 for the Short-Term Group and 18.9% (137/723 for the Long-Term Group. The subjects of each group were also subdivided into subgroups according to the treatments being received. Regarding the seminal profile, we did not observe a significant difference between the Long-Term, Short-Term or the Control Group. However, regarding the subgroups, we found a significant decrease in sperm number and progressive motility percentage in the subjects receiving treatment with antihypertensive drugs compared with the other subgroups and the Control Group. Conclusions: In the management of infertile couples, the potential negative impact on seminal parameters of any drugs being taken as Long-Term Therapy should be considered. The pathogenic mechanism needs to be clarified.

  6. Formulation and clinical evaluation of silymarin pluronic-lecithin organogels for treatment of atopic dermatitis

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    Mady FM

    2016-03-01

    Full Text Available Fatma M Mady,1,2 Hanaa Essa,2 Tarek El-Ammawi,3 Hamdy Abdelkader,2 Amal K Hussein2 1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Taibah University, Medina, Saudi Arabia; 2Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, Egypt; 3Department of Dermatology, STDs, and Andrology, Minia University Hospital, Minia, Egypt Abstract: Silymarin is a naturally occurring flavonoid drug; evidence from recent research has highlighted its use as a potential treatment for atopic dermatitis (AD. Both poor water solubility and drug permeability have hindered the percutaneous absorption of silymarin. Formulation of silymarin into pluronic-lecithin organogel (PLO basis for topical skin delivery is the main aim of this work. Six different PLO formulations were prepared containing various pluronic to lecithin ratios using two cosolvent systems of ethyl alcohol and dimethyl sulfoxide. Formulation 2 (20% pluronic and 3% lecithin was found to be the optimal base for topical delivery of silymarin as it showed optimum pH, viscosity, drug content, and satisfactory in vitro silymarin permeation. The silymarin PLO formulation significantly relieved inflammatory symptoms of AD such as redness, swelling, and inflammation. These findings warrant the ability for application of these novel silymarin PLO formulations as a novel treatment for AD. Keywords: silymarin, pluronic lecithin organogel, atopic dermatitis, skin penetration 

  7. Management of the infertile couple: an evidence-based protocol

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    Kamel Remah M

    2010-03-01

    Full Text Available Abstract Background Infertility is defined as inability of a couple to conceive naturally after one year of regular unprotected sexual intercourse. It remains a major clinical and social problem, affecting perhaps one couple in six. Evaluation usually starts after 12 months; however it may be indicated earlier. The most common causes of infertility are: male factor such as sperm abnormalities, female factor such as ovulation dysfunction and tubal pathology, combined male and female factors and unexplained infertility. Objectives The aim of this study is to provide the healthcare professionals an evidence-based management protocol for infertile couples away from medical information overload. Methods A comprehensive review where the literature was searched for "Management of infertility and/or infertile couples" at library website of University of Bristol (MetaLib by using a cross-search of different medical databases besides the relevant printed medical journals and periodicals. Guidelines and recommendations were retrieved from the best evidence reviews such as that from the American College of Obstetricians and Gynaecologists (ACOG, American Society for Reproductive Medicine (ASRM, Canadian Fertility and Andrology Society (CFAS, and Royal College of Obstetricians and Gynaecologists (RCOG. Results A simple guide for the clinicians to manage the infertile couples. Conclusions The study deploys a new strategy to translate the research findings and evidence-base recommendations into a simplified focused guide to be applied on routine daily practice. It is an approach to disseminate the recommended medical care for infertile couple to the practicing clinicians.

  8. Cost-effectiveness of varicocele surgery in the era of assisted reproductive technology

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    Kelly A Chiles

    2016-01-01

    Full Text Available The advent of innovative techniques for addressing infertility has made for exciting times in the arena of andrology. The success of microTESE for retrieving sperm has enabled azoospermic men to have the opportunity to father biological children when it was previously impossible. The ability to offer a variety of assisted reproductive techniques that includes intracytoplasmic sperm injection has opened the door for couples with male factor infertility who were otherwise untreatable. With the multitude of options available to infertile couples, however, comes an unsurprising degree of controversy regarding what treatments should be offered and when. Complicating the picture is the question of if and when varicocele repair should be undertaken, and the financial implications of the treatment decisions that are made. The infertile couple with varicocele warrants careful consideration. The overall efficacy of varicocele repair as well as cost-effectiveness of repair compared to immediate microTESE in azoospermic men and assisted reproductive technology in men with suboptimal semen parameters will be reviewed.

  9. An easy, reproducible and cost-effective method for andrologists to improve the laboratory diagnosis of non-obstructive azoospermia: a novel microcentrifugation technique

    Science.gov (United States)

    Monteiro, Rosa Alice Casemiro; Pariz, Juliana Risso; Pieri, Patrícia de Campos; Hallak, Jorge

    2016-01-01

    ABSTRACT This study describes a new method of microcentrifugation as an improved, viable, cost-effective option to the classical Cytospin apparatus to confirm azoospermia. Azoospermic semen samples were evaluated for cryptozoospermia by a centrifugation method similar to that of World Health Organization guidelines (2010; entire specimen centrifuged at 3000g for 15 min, and aliquots of the pellet examined). Then, if no sperm were detected, the pellet from that procedure was resuspended in culture medium, centrifuged (2000g for 15 min), and the entire pellet spread on a 4 X 6mm area of a slide and stained using the Christmas tree method (Nuclear-Fast solution and picric acid). The entire stained area was examined for the presence or absence of sperm. A total of 148 azoospermic samples (after standard WHO diagnosis) were included in the study and 21 samples (14.2%) were identified as sperm-positive. In all microcentrifugation slides, intact spermatozoa could be easily visualized against a clear background, with no cellular debris. This novel microcentrifugation technique is clearly a simple and effective method, with lower cost, increasing both sensitivity and specificity in confirming the absence or presence of spermatozoa in the ejaculate. It may represent a step forward of prognostic value to be introduced by andrology laboratories in the routine evaluation of patients with azoospermia in the initial semen analysis. PMID:27136479

  10. A comparative evaluation of semen parameters in pre- and post-Hurricane Katrina human population

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    Caner Baran

    2015-01-01

    Full Text Available A natural disaster leading to accumulation of environmental contaminants may have substantial effects on the male reproductive system. Our aim was to compare and assess semen parameters in a normospermic population residing in the Southern Louisiana, USA area pre- and post-Hurricane Katrina. We retrospectively evaluated semen analyses data (n = 3452 of 1855 patients who attended the Tulane University Andrology/Fertility Clinic between 1999 and 2013. The study inclusion criteria were men whose semen analyses showed ≥ 1.5 ml volume; ≥15 million ml -1 sperm concentration; ≥39 million total sperm count; ≥40% motility; >30% morphology, with an abstinence interval of 2-7 days. After the inclusion criteria applied to the population, 367 normospermic patients were included in the study. Descriptive statistics and group-based analyses were performed to interpret the differences between the pre-Katrina (Group 1, 1999-2005 and the post-Katrina (Group 2, 2006-2013 populations. There were significant differences in motility, morphology, number of white blood cell, immature germ cell count, pH and presence of sperm agglutination, but surprisingly there were no significant differences in sperm count between the two populations. This long-term comparative analysis further documents that a major natural disaster with its accompanied environmental issues can influence certain semen parameters (e.g., motility and morphology and, by extension, fertility potential of the population of such areas.

  11. Evaluation of sexual maturity of young bulls from different breeds selected for post-weaning weight

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    Fabio Morato Monteiro

    2011-01-01

    Full Text Available Sperm traits of 243 young bulls from Caracu (n=62, Gir (n=23, Guzerá (n=59 and Nellore (n=99 breeds, with 20-25 months of age, from the Breeding Program of Estação Experimental de Zootecnia de Sertãozinho, were analyzed. On the day of breeding soundness evaluation animals were weighed, the scrotal circumference was measured and the semen was collected by electroejaculation. The sperm motility, vigor and morphology were assessed and the animals were classified according to the andrological classification by points (CAP. No difference was observed among breeds for any seminal trait evaluated, although Nelore presented lower scrotal circumference average than the other breeds. When the animals were classified by body weight, it was observed that the heavier animals presented greater scrotal circumference, better seminal characteristics and, consequently, greater percentage of these animals were considered sexually mature comparing with the other body weight groups. It was concluded that the animals selected for post-weaning and reared on pasture from the taurine adapted breed Caracu and from the zebu breeds Gir, Guzerá and Nelore have proved able to reproduction at 23.2, 23.4, 22.7 and 22.8 months, respectively, corresponding to age which reached an average weight of 452, 422, 470 and 467 kg respectively.

  12. The Experiences of e-Learning Implementation in CAO - Results of the Pilot Project

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    Zsuzsanna Vörös

    2010-12-01

    Full Text Available The various tasks of Central Agricultural Office are carried out by its central and regional directorates. For performing a high standard labour, well- and continuously educated team in needed, so the more thousands of colleagues working at central and regional levels have to be trained. Beside the traditional training forms – and built to them - there was a need for implementing a new distant teaching system, which provides a comprehensive distance education, resting on multimedia foundations, for the all colleagues of Central Agricultural Office working in different parts of the country and in different professional areas. The aim of our publication is to show how we introduced the e-Learning education within the distance education framework system of CAO, and to share our experiences obtained during the pilot training. The five courses of pilot training turned out a success: the results of examinations (the mean values: 84-91% and evaluations of questionnaires filled out by more than 200 colleagues taking part in training proved the entitlement of e-Learning education in CAO. However this method needs additional refinements in order to adapt to the specific requirements of andrology.

  13. [Scientific activity of the University Urological Department in Budapest after WWII (1946-1956)].

    Science.gov (United States)

    Romics, I; Romics, M

    2016-04-01

    The authors studied the publications written by the staff of the University Department of Urology in Budapest, Hungary between 1946 and 1956. The collection was contributed on the occasion of Professor Babics's 10-year-long chairmanship. Over a period of 10 years, 214 papers were published by 15 urologists, including 3 books and 3 PhD theses; 16 papers were published in German, 22 in English, 2 in French, and 1 in Italian. The most frequent topic of the papers (26) was basic science (e.g., ureter motility, lymph circulation, intrarenal pressure condition). Other papers dealt with nephrology, artificial kidneys, TURP, and nephron-sparing renal surgery. Some articles examined various types of malignant tumors and benign prostatic hyperplasia, while 17 publications focused on the topic of andrology. Tuberculosis was also discussed by the authors. Despite political isolation, the communist dictatorship, poverty, the lack of health equipment, physicians educated before WWII with their work morality and hard work managed to perform contemporary clinical and basic scientific research. PMID:27000284

  14. [Reproductive aspects of celiac disease].

    Science.gov (United States)

    Stazi, Anna Velia; Trinti, Biagino

    2005-01-01

    In the past, celiac disease (CD), or intolerance to gluten, was considered a rare disease of infancy characterized by chronic diarrhea with malabsorption and delayed growth. Besides the overt enteropathy, there are other clinic and subclinical forms which appear later in life. Target organs are not limited to the gut, but include liver, thyroid, skin and female and male reproductive systems. CD interference on reproduction is related to the multifactorial nature of the disease, whose pathological manifestations can be modulated, besides gluten, by different concurrent genetic and environmental factors. CD induces malabsorption with consequent deficiencies of micronutrients such as iron, folic acid and vitamin K, which are essential for organogenesis, and fat-soluble vitamins important for spermatogenesis. Regarding endocrine disorders, the deficiencies of specific trace elements on ovarian function could explain its involvement in the increased risk of female osteoporosis in CD patients. Affected males show a picture of tissue resistance to androgens; the increases of follicle-stimulating hormone and prolactin, not associated with infertility, may indicate an imbalance at hypothalamus-pituitary level, with general effects on health. Since reproductive alterations are reversible, adoption of a gluten-free diet supported by early diagnosis is important. Therefore, the detection of early biomarkers, such as deficiencies of vitamins and/or iron and andrological or endocrinological dysfunctions, should trigger timely strategies for prevention and treatment. PMID:16250182

  15. Leukocytes and oxidative stress: dilemma for sperm function and male fertility

    Institute of Scientific and Technical Information of China (English)

    Ralf R Henkel

    2011-01-01

    Spermatozoa are constantly exposed to the interphase between oxidation through high amounts of reactive oxygen species (ROS) and leukocytes, and reduction by means of scavengers and antioxidants. Considering the very special functions as being the only cells with such high polarization and exerting their functions outside the body, even in a different individual, the female genital tract, the membranes of these cells are chemically composed of an extraordinary high amount of polyunsaturated fatty acids. This in turn, renders them very susceptible to oxidative stress, which is defined as an imbalance between oxidation and reduction towards the oxidative status. As a result, ROS deriving from both leukocytes and the male germ cells themselves cause a process called 'lipid peroxidation' and other damages to the sperm cell. On the other hand, a certain limited amount of ROS is essential in order to trigger vital physiological reactions in cells, including capacitation or the acrosome reaction in sperm. The treatment of patients with antioxidants to compensate the oxidative status caused by oxidative stress is highly debated as uncontrolled antioxidative treatment might derail the system towards the reduced status, which is also unphysiological and can even induce cancer. This paradox is called the 'antioxidant paradox'.Therefore, a proper andrological diagnostic work-up, including the evaluation of ROS levels and the antioxidant capacity of the semen,has to be carried out beforehand, aimed at keeping the fine balance between oxidation and scavenging of vital amounts of ROS.

  16. Androgen deprivation therapy (castration therapy) and pedophilia: What's new.

    Science.gov (United States)

    Silvani, Mauro; Mondaini, Nicola; Zucchi, Alessandro

    2015-09-01

    Andrology is a constantly evolving discipline, embracing social problems like pedophilia and its pharmacological treatment. With regard to chemical castration, the andrologist may perform an important role as part of a team of specialists. At present, no knowledge is available regarding hormonal, chromosomal or genetic alterations involved in pedophilia. International legislation primarily aims to defend childhood, but does not provide for compulsory treatment. We reviewed international literature that, at present, only comprises a few reports on research concerning androgen deprivation. Most of these refer to the use of leuprolide acetate, rather than medroxyprogesterone and cyproterone acetate, which present a larger number of side effects. Current opinions on chemical castration for pedophilia are discordant. Some surveys confirm that therapy reduces sexual thoughts and fantasies, especially in recidivism. On the other hand, some authors report that chemical castration does not modify the pedophile's personality. In our opinion, once existing legislation has changed, andrologists could play a significant role in the selection of patients to receive androgen deprivation therapy, due in part to their knowledge about its action and side effects. PMID:26428645

  17. Publication rates of full-text journal articles converted from abstracts presented during the 22nd Turkish National Urology Congress

    Science.gov (United States)

    Kocaaslan, Ramazan; Kayalı, Yunus; Tok, Adem; Tepeler, Abdulkadir

    2016-01-01

    Objective To analyze the publication rates of full-text journal articles converted from the abstracts presented in the 22nd Turkish National Urology Congress in 2012. Material and Methods A total of 576 abstracts accepted for presentation at the 22nd Turkish National Urology Association Meeting were identified from the published abstract book. The abstracts were categorized into subsections such as endourology and pediatric urology. The subsequent publication rate for the studies was evaluated by scanning PubMed Medline. Abstracts published before the proceedings were excluded from the study. Results The abstracts were categorized as being presented orally (n=155), by poster (n=421), or by video (n=78). Of the 28 (18.3%) of 155 oral and 34 (8.15%) of 421 poster presentations, were subsequently published in several journals until March 2015. The publication rates of the abstracts based on urology subsections were as follows: neurology (25%), andrology (18.6%), endourology (17.2%), urolithiasis (15.3%), general urology (12.5%), infectious diseases (7.14%), pediatric urology (6.25%), uro-gynecology (6.06%), reconstructive urology (5.8%), and urooncology (3.8%). The average time to publication was 11.77 (0–33) months. Conclusion This is the first study assessing the publication rates of abstracts presented at a Turkish National Urology Congress. It reveals that more qualified randomized studies need to be done to improve the rate of publication. PMID:27011876

  18. 2217例生殖道患者支原体感染状况及药敏分析%Analysis of 2217 cases of reproductive tract mycoplasma infection and drug sensitivity

    Institute of Scientific and Technical Information of China (English)

    朱云凤; 王昌壁; 陈丽娟

    2013-01-01

    Objective To analysis the reproductive tract mycoplasma infection status and drug resistance in outpatients, and understand their characteristics. Methods 2217 samples from andrology and gynecology outpatients in our hospital were collected to mycoplasma culture and drug susceptibility test, which results were analyzed using χ² test. Results Detection rates of ureaplasma urealyticum(UU), mycoplasma hominis(MH) and UU+MH were 42.2%, 3.6% and 19.7%, respectively. The total positive rate of mycoplasma was 65.5%. There were statistical significance between UU and MH (P90%;其它大多数药物对UU 的敏感性普遍高于 MH;MH 对罗红霉素的敏感性最低,UU 对甲砜霉素敏感性最低.结论生殖道患者中支原体感染率较高;且女性>男性;UU>MH.仅3种药物对两种支原体敏感率都较高,对 UU敏感率普遍高于 MH,男性不育症患者感染状况与男性生殖道炎症患者相似.

  19. PROGNOSTIC FACTORS OF PROSTATE CANCER BEFORE AND AFTER RADICAL PROSTATECTOMY

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    E. I. Veliev

    2014-07-01

    Full Text Available Objective: to assess a correlation between the preoperative prognostic characteristics and the pathologic stage and to determine whether a positive surgical margin is present after radical prostatectomy (RPE.Materials and methods. The materials of 224 patients with prostate cancer (PC who had undergone RPE at the Clinic of Urology and Surgical Andrology, Russian Medical Academy of Postgraduate Education, were analyzed.Results. The patients’ median age was 62 (43–78 years. Sixty-seven (29.9 %, 46 (20.5%, and 111 (49.6 % patients were referred to as low-, moderate-, and high-risk groups, respectively. A positive surgical margin was observed in 11.9, 28.3, and 38.7 % of the patients in the low-, moderate-, and high-risk groups, respectively (р = 0.0003. The predictors of a positive surgical margin were the percent of involved biopsy specimens (R = 0.34 and Gleason score (R = 0.31 and perineural invasion. According to multivariate analysis, neither the preoperative level of prostate-specific antigen, nor the clinical stage showed any correlation with the positive surgical margin and the pathologic stage after RPE.

  20. Depression,Antidepressants and Male Sexual Dysfunction%抑郁和抗抑郁药物与男性性功能障碍

    Institute of Scientific and Technical Information of China (English)

    李宏军

    2009-01-01

    抑郁、抗抑郁药物及男性性功能障碍三者关系密切,本文系统阐述了三者的相互关系,简要介绍了常用抗抑郁药物分类及其不良反应,重点论述了抑郁及抗抑郁药物对男性性功能的不良影响、抗抑郁药物治疗男性性功能障碍及注意事项,对男科临床工作有一定指导和借鉴意义.%Depression,antidepressants and male sexual dysfunction are closely correlated.This article aims to expound their complicated correlation and give a brief introduction to the classification and adverse effects of common antidepressants.focusing on the influences of depression and antidepressants on male sexual dysfunction,the treatment of male sexual dysfunction with antidepressants, and the points for attention in the medication,which might offer some guidance for the clinical practice in andrology.

  1. Androgen deprivation therapy (castration therapy and pedophilia: What’s new

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    Mauro Silvani

    2015-09-01

    Full Text Available Andrology is a constantly evolving discipline, embracing social problems like pedophilia and its pharmacological treatment. With regard to chemical castration, the andrologist may perform an important role as part of a team of specialists. At present, no knowledge is available regarding hormonal, chromosomal or genetic alterations involved in pedophilia. International legislation primarily aims to defend childhood, but does not provide for compulsory treatment. We reviewed international literature that, at present, only comprises a few reports on research concerning androgen deprivation. Most of these refer to the use of leuprolide acetate, rather than medroxyprogesterone and cyproterone acetate, which present a larger number of side effects. Current opinions on chemical castration for pedophilia are discordant. Some surveys confirm that therapy reduces sexual thoughts and fantasies, especially in recidivism. On the other hand, some authors report that chemical castration does not modify the pedophile’s personality. In our opinion, once existing legislation has changed, andrologists could play a significant role in the selection of patients to receive androgen deprivation therapy, due in part to their knowledge about its action and side effects.

  2. Alcohol intake and cigarette smoking: Impact of two major lifestyle factors on male fertility

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    Gaur Dushyant

    2010-01-01

    Full Text Available Context: Lifestyle factors, like alcohol intake and cigarette smoking, have been reported to affect male fertility. Aims: To find out the specific impact of alcohol and smoking on semen quality of male partners of couples seeking treatment for primary infertility. Materials and Methods: From the semen samples analyzed in our andrology laboratory, results of 100 alcoholics and 100 cigarette smoker males were studied following WHO guidelines and compared with 100 strict nonalcoholic and nonsmoker males for presence of asthenozoospermia, oligozoospermia and teratozoospermia. Statistical Analysis: Data was analyzed by F- test using Microsoft Office Excel 2003. Results: Only 12% alcoholics and six per cent smokers showed normozoospermia compared to 37 % nonalcoholic nonsmoker males. Teratozoospermia, followed by oligozoospermia dominated alcoholics. Overall impact of asthenozoospermia and teratozoospermia, but not of oligozoospermia, was observed in smokers. Light smokers predominantly showed asthenozoospermia. Heavy alcoholics and smokers showed asthenozoospermia, teratozoospermia as well as oligozoospermia. Conclusions: Asthenozoospermia, the most common semen variable in our study, can be an early indicator of reduction in quality of semen. Alcohol abuse apparently targets sperm morphology and sperm production. Smoke-induced toxins primarily hamper sperm motility and seminal fluid quality. Progressive deterioration in semen quality is related to increasing quantity of alcohol intake and cigarettes smoked.

  3. Erectile function and male reproduction in men with spinal cord injury: a review.

    Science.gov (United States)

    Dimitriadis, F; Karakitsios, K; Tsounapi, P; Tsambalas, S; Loutradis, D; Kanakas, N; Watanabe, N T; Saito, M; Miyagawa, I; Sofikitis, N

    2010-06-01

    Spinal cord injury (SCI) in men results in defects in erectile function, ejaculatory process and male reproductive potential. There are alterations in the capacity of men with SCI to achieve reflexogenic, psychogenic and nocturnal erections. The sexual function in different stages after SCI and the types of erections depend mainly on the completeness of the injury and the level of neurological damage. Furthermore, most of the SCI men demonstrate defects concerning the entrance of semen into the posterior urethra and the expulsion of the semen through the penile urethra and the urethral orifice. In addition, SCI men develop defects in the secretory function of the Leydig cells, Sertoli cells and the male accessory genital glands. The overall result is a decreased quality of the semen is recovered either with penile vibratory stimulation (PVS) or with electroejaculation. Nowadays the therapeutic andrological approach of SCI men focuses on achievement of erectile function, recovery of spermatozoa and assisted reproductive technology. The first line of therapy recommended for infertility in SCI men is collection of semen via PVS with concomitant evaluation of total motile sperm yields for assisted conception which may include intravaginal insemination, intrauterine insemination, or in vitro fertilisation/intracytoplasmic sperm injection. Patients failing PVS may be referred for electroejaculation or surgical sperm retrieval. PMID:20500744

  4. [Echo-color-Doppler in male pelvic congestion syndrome].

    Science.gov (United States)

    Sarteschi, Lelio Mario; Simi, Stefano; Turchi, Paolo; DeMaria, Maurizio; Morelli, Girolamo

    2002-12-01

    The pelvic congestion syndrome has been widely studied in the female sex, while there are not many publications on the male equivalent. Prostatitis represent the most frequent affections of the genito-urinary male tract that require the urologic consult, but in the majority of the cases the etiology of such affections remains unknown. Some forms of microscopic hematuria or macroscopic hematuria are also cryptogenetic. Varicocelectomy is widely given in the infertile patients, but not always the intervention achieves a recovery of the semen quality. In this work we revisit the anatomy of the pelvic male venous drain and we depict its objective findings with the echo-color-Doppler sonography (ECD). The purpose of the study is to encourage a polycentric uro-andrologic search on large numbers, with the goal of resolve if the ECD pictures of congestion pelvic syndrome could have relation with some "prostatitis syndromes", with some cryptogenetic hematuria and/or with the prognosis of the infertile patients undergone to varicocelectomy. PMID:12508723

  5. Intrauterine pregnancy following low-dose gonadotropin ovulation induction and direct intraperitoneal insemination for severe cervical stenosis

    Directory of Open Access Journals (Sweden)

    Sills E Scott

    2002-11-01

    Full Text Available Abstract Background We present a case of primary infertility related to extreme cervical stenosis, a subset of cervical factor infertility which accounts for approximately 5% of all clinical infertility referrals. Case presentation A 37 year-old nulligravida was successfully treated with ovulation induction via recombinant follicle stimulating hormone (FSH and direct intraperitoneal insemination (IPI. Anticipating controlled ovarian hyperstimulation with in vitro fertilization/embryo transfer (IVF, the patient underwent hysteroscopy and cervical recanalization, but safe intrauterine access was not possible due to severe proximal cervical stricture. Hysterosalpingogram established bilateral tubal patency and confirmed an irregular cervical contour. Since the cervical canal could not be traversed, neither standard intrauterine insemination nor transcervical embryo transfer could be offered. Prepared spermatozoa were therefore placed intraperitoneally at both tubal fimbria under real-time transvaginal sonographic guidance using a 17 gage single-lumen IVF needle. Supplementary progesterone was administered as 200 mg/d lozenge (troche plus 200 mg/d rectal suppository, maintained from the day following IPI to the 8th gestational week. A singleton intrauterine pregnancy was achieved after the second ovulation induction attempt. Conclusions In this report, we outline the relevance of cervical factor infertility to reproductive medicine practice. Additionally, our andrology evaluation, ovulation induction approach, spermatozoa preparation, and insemination technique in such cases are described.

  6. Flow cytometry for the assessment of animal sperm integrity and functionality: state of the art

    Institute of Scientific and Technical Information of China (English)

    Md.Sharoare Hossain; Anders Johannisson; Margareta Wallgren; Szabolcs Nagy; Amanda Pimenta Siqueira; Heriberto Rodriguez-Martinez

    2011-01-01

    Flow cytometry is now a recognized methodology within animal spermatology, and has moved from being a research tool to become routine in the assessment of animal semen destined to breeding. The availability of 'bench-top' flow cytometers and of newer and versatile markers for cell structure and function had allowed the instrumentation to measure more sperm parameters, from viability to reactiveness when exposed to exogenous stimuli, and to increase our capabilities to sort spermatozoa for potential fertilizing capacity, or chromosomal sex. The present review summarizes the state of the art regarding flow cytometry applied to animal andrology, albeit keeping an open comparative intent. It critically evaluates the present and future capabilities of flow cytometry for the diagnostics of potential fertility and for the development of current reproductive technologies such as sperm freezing, sperm selection and sperm sorting. The flow cytometry methods will probably further revolutionize our understanding of the sperm physiology and their functionality, and will undoubtedly extend its application in isolating many uncharacterized features of spermatozoa. However, continuous follow-up of the methods is a necessity owing to technical developments and the complexity of mapping spermatozoa.

  7. PROGNOSTIC FACTORS OF SURVIVAL IN RENAL CANCER

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    A. V. Seriogin

    2014-08-01

    Full Text Available The purpose of the study was to reveal the independent anatomic, histological, and clinical factors of cancer-specific survival in patients with renal-cell carcinoma (RCC. For this, the authors retrospectively analyzed their experience with radical surgical treatments in 73 RCC patients operated on at the Department of Urology and Surgical Andrology, Russian Medical Academy of Postgraduate Education, from January 1, 1999 to December 31, 2004; their outcomes have become known by the present time. There was a statistically significant correlation of cancer-specific survival with its parameters, such as pathological stage of a tumor, its maximum pathological size, differentiation grade, involvement of regional lymph nodes, venous tumor thrombosis, level of thrombocytosis, and degree of the clinical symptoms of the disease. Multivariate analysis of survival in RCC in relation to the prognostic factors could reveal odd ratios for the limit values of significant prognostic factors. The statistically significant prognostic values established in the present study, as well as the molecular factors the implication of which is being now investigated can become in future an effective addition to the TNM staging system to define indications for certain treatments and to predict survival in RCC  

  8. Bibliometrics: tracking research impact by selecting the appropriate metrics.

    Science.gov (United States)

    Agarwal, Ashok; Durairajanayagam, Damayanthi; Tatagari, Sindhuja; Esteves, Sandro C; Harlev, Avi; Henkel, Ralf; Roychoudhury, Shubhadeep; Homa, Sheryl; Puchalt, Nicolás Garrido; Ramasamy, Ranjith; Majzoub, Ahmad; Ly, Kim Dao; Tvrda, Eva; Assidi, Mourad; Kesari, Kavindra; Sharma, Reecha; Banihani, Saleem; Ko, Edmund; Abu-Elmagd, Muhammad; Gosalvez, Jaime; Bashiri, Asher

    2016-01-01

    Traditionally, the success of a researcher is assessed by the number of publications he or she publishes in peer-reviewed, indexed, high impact journals. This essential yardstick, often referred to as the impact of a specific researcher, is assessed through the use of various metrics. While researchers may be acquainted with such matrices, many do not know how to use them to enhance their careers. In addition to these metrics, a number of other factors should be taken into consideration to objectively evaluate a scientist's profile as a researcher and academician. Moreover, each metric has its own limitations that need to be considered when selecting an appropriate metric for evaluation. This paper provides a broad overview of the wide array of metrics currently in use in academia and research. Popular metrics are discussed and defined, including traditional metrics and article-level metrics, some of which are applied to researchers for a greater understanding of a particular concept, including varicocele that is the thematic area of this Special Issue of Asian Journal of Andrology. We recommend the combined use of quantitative and qualitative evaluation using judiciously selected metrics for a more objective assessment of scholarly output and research impact. PMID:26806079

  9. 敦煌遗书性爱和谐医方探析%On Medical Recipes of Sexual Harmony in DunHuang YiShu

    Institute of Scientific and Technical Information of China (English)

    孙守华

    2012-01-01

    DunHuang medical recipes of sexual harmony were analyzed primarily from the principles of compatibility, medicinal principles, the types of preparations and the way of administration. Systematic study on literature of DunHuang medical recipes of sexual harmony not only can help the excavation of DunHuang medical literature, but also is valuable for current application of ancient recipes in andrology and gynecology of TCM as well as further study of TCM sexology.%从组方原则、用药原则、制剂类型、给药途径等方面对敦煌性爱和谐医方进行了医药学方面的初步分析探讨;指出对敦煌性爱和谐医方文献进行系统研究,不仅对敦煌医学文献的发掘整理有一定作用,而且对于中医临床男科、妇科疾病的古方今用及中医性医学的进一步研究具有参考、利用价值.

  10. THE ADDITION OF CAFFEINE IN EARLE’S BALANCED SALT SOLUTION MEDIA WITH WASHING UP METHOD INCREASE MEMBRANE INTEGRITY AND ACROSOMAL SPERM

    Directory of Open Access Journals (Sweden)

    B. K. Satriyasa

    2014-12-01

    Full Text Available Background: caffeine, a methylxanthine derivate, appears to inhibit phosphodiesterase, thereby inhibiting the break down of cAMP and increasing its concentration inside cell. This study aims to assess the effect of caffeine addition in Earles’s Balanced Salt Solution (EBSS on the increase in membrane integrity and acrosome reaction of spermatozoa using swim up method. Methods: This study was carried out at the Clinic of Sexology and Andrology, Sanglah Public Hospital at Denpasar Bali-Indonesia. This study was an experimental study using the design of pre and post test paired control group design. The samples were sperm specimens of eighteen infertile couple male or volunteers who were infertile with age ranged between 20-40 years old. The samples   were divided into two groups: treatment group (caffeine + EBSS and control group (EBSS. The data were analysed statistically by normality test (Kolmogorov - Smirnov Goodness of Fit Test, Homogeneity test, and Paired Student’s t test.  Results: The results showed that the caffeine addition in EBSS medium could increase significantly (p<0.05.  The integrity of the sperm membrane obtained were from 81.30 % to 86.60 % and acrosomal reaction from 82.60% to 89.60% evaluated by hypo-osmotic swelling test (HOS. The conclusion of this study is that addition of caffeine in EBSS medium increases significantly membrane integrity and acrosomal reaction of the human sperm.

  11. Correlation between penile cavernosal artery blood flow and retinal vascular findings in arteriogenic erectile dysfunction

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    Ahmed M Emarah

    2010-09-01

    Full Text Available Ahmed M Emarah1, Shawky M El-Haggar2, Ihab A Osman2, Abdel Wahab S Khafagy21Departments of Ophthalmology, 2Andrology and Sexology, Cairo University Hospital, EgyptObjectives: Arteriogenic erectile dysfunction (ED is a target organ disease of atherosclerosis, and therefore might be a predictor of systemic atherosclerosis. Being systemic, it might be possible to evaluate the extent of atherosclerosis from retinal vascular findings. We investigated the possible correlation between penile cavernosal artery blood flow and retinal vascular findings in patients with arteriogenic ED.Patients and methods: Sixty patients with ED were divided according to the peak systolic velocity (PSV in their penile cavernosal arteries into two groups; Group A included 30 patients with PSV less than 25 cm/sec, and Group B included 30 patients with PSV more than 35 cm/sec. Blood flow in the penile cavernosal artery was measured with color Doppler ultrasonography. All patients were assessed by ocular fundus examination under amydriatic conditions to evaluate retinal vascular atherosclerotic changes using Hyman’s classification.Results: Evidence of retinal vascular atherosclerotic changes was found in 19 patients (63.3% in Group A and in 10 patients (33.3% in Group B.Conclusions: Our study confirms the possibility of predicting penile arterial vascular status in patients with ED from their retinal vascular findings by using amydriatic simple, practical funduscopy.Keywords: erectile dysfunction, atherosclerosis, retinal vascular atherosclerosis

  12. 精液中多形核粒细胞弹性蛋白酶与患无症状生殖道炎症男性的年龄相关性%Age-related changes in seminal polymorphonuclear elastase in men with asymptomatic inflammation of the genital tract

    Institute of Scientific and Technical Information of China (English)

    Ralf Henkel; Gesa Maaβ; Andreas Jung; Gerhard Haidl; Wolf-Bernhard Schill; Hans-Christian Schuppe

    2007-01-01

    目的:研究与年龄相关的男性生殖道炎症.方法:在德国吉森大学皮肤病学和男性学中心的男性病临床病例中随机选取4265例病例,测量其射精量、pH值、精子浓度、精子总运动性和程序性运动性、多形核粒细胞弹性蛋白酶浓度、过氧化物酶阳性细胞的数量和果糖含量,并研究这些指标与病人年龄的相关性.结果:射精量、精子运动性和果糖含量与年龄无相关性,精子浓度、多形核粒细胞弹性蛋白酶浓度和pH值与年龄相关.男性生殖道炎症(定义为多形核粒细胞弹性蛋白酶浓度>250 ng/mL)随着患者年龄的增长更普遍且患病率显著增长.多形核粒细胞弹性蛋白酶浓度与精子的运动性无关.作为精囊腺标记的果糖与多形核粒细胞弹性蛋白酶水平,过氧化物酶阳性细胞的数量和精子的运动性不相关.结论:多形核粒细胞弹性蛋白酶含量是老年男性生殖道炎症的标记物,它的显著增加在局部炎症调节机制中与年龄相关.因为多形核粒细胞弹性蛋白酶与精子运动性不相关,所以这种酶的直接抑制效果可以被排除.%Aim: To investigate age-related inflammatory events in the male genital tract. Methods: In a total of 4265 randomly collected patients attending the andrological outpatient clinic of the Center for Dermatology and Andrology, University of Giessen, Germany, ejaculate volume, pH-value, sperm concentration, total and progressive sperm motility, concentration of polymorphonuclear (PMN) elastase, number of peroxidase-positive cells and fructose were measured and correlated with patient's age. Results: While ejaculate volume, motility and fructose all correlated negatively with age, sperm concentration, PMN elastase and the pH-value showed a positive correlation. The prevalence of male genital tract inflammation (as defined by PMN elastase > 250 ng/mL) and its severity increased significantly. PMN elastase did not correlate

  13. Causes of sperm retrieval failure by masturbation during routine semen examination%男科门诊精液常规检查时取精失败的原因及解决措施

    Institute of Scientific and Technical Information of China (English)

    梁世坤; 梁季鸿; 韦国强; 宋卫儒; 朱春晖; 张迅; 李广裕

    2012-01-01

    目的 探讨男性不育患者在男科门诊精液常规检查时手淫取精失败的常见原因及相应的解决措施. 方法 对2003~2010年在我科门诊行精液常规检查时取精失败的120例患者进行回顾性分析. 结果 取精失败常见的影响因素有:不适应取精室环境(65例,占54.17%)、缺乏手淫射精经验(21例,占17.50%)、患有勃起功能障碍(ED)(17例,占14.17%)或原发/继发性不射精(9例,占7.50%)、某些药物的影响(5例,占4.17%)等;进行个体化的辅导、处理或治疗后共有107例(89.17%)患者成功取精. 结论 男科门诊精液常规检查时取精失败的常见原因有:不适应取精室环境、缺乏手淫射精经验、患有ED或原发/继发性不射精,医护人员要对他们进行个体化的有针对性的辅导、处理或治疗.%Objective: To explore the causes of sperm retrieval failure by masturbation during routine semen examination and how to solve them. Methods: One hundred and twenty patients who were sperm retrieval failure by masturbation during routine semen examination in outpatient of andrology were retrospectively analyzed. Results: The common causes of sperm retrieval failure by masturbation including: inadaptation of the room environment (65 cases, 54. 17%), absence of masturbation experience (21 cases, 17. 50%), suffering erectile dysfunction (ED) (17 cases, 14. 17%), primary or secondary defective ejaculation (9 cases,7. 50%), influencing by some drugs(5 cases,4. 17%)and so on. After being treated by doctors and nurses individually, 107 (89. 17%) of the patients successfully ejaculated. Conclusions: The common causes of sperm retrieval failure by masturbation during routine semen examination in outpatient of andrology include inadaptation of the room environment, absence of masturbation experience, suffering ED, primary or secondary ejaculation disorder, and influencing by some drugs. To handle this problem, doctors and nurses should direct or

  14. EAA/EMQN best practice guidelines for molecular diagnosis of Y-chromosomal microdeletions: state-of-the-art 2013

    Science.gov (United States)

    Krausz, C; Hoefsloot, L; Simoni, M; Tüttelmann, F

    2014-01-01

    The molecular diagnosis of Y-chromosomal microdeletions is a common routine genetic test which is part of the diagnostic workup of azoospermic and severe oligozoospermic men. Since 1999, the European Academy of Andrology (EAA) and the European Molecular Genetics Quality Network (EMQN) have been actively involved in supporting the improvement of the quality of the diagnostic assays by publication of the laboratory guidelines for molecular diagnosis of Y-chromosomal microdeletions and by offering external quality assessment trials. The present revision of the 2004 laboratory guidelines summarizes all the clinical novelties related to the Y chromosome (classic, partial and gene-specific deletions, genotype–phenotype correlations, methodological issues) and provides an update on the results of the quality control programme. These aspects also reflect the consensus of a large group of specialists present at a round table session during the recent Florence-Utah-Symposium on ‘Genetics of male infertility’ (Florence, 19–21 September, 2013). During the last 10 years the gr/gr deletion has been demonstrated as a significant risk factor for impaired sperm production. However, the screening for this deletion type in the routine diagnostic setting is still a debated issue among experts. The original basic protocol based on two multiplex polymerase chain reactions remains fully valid and appropriate for accurate diagnosis of complete AZF deletions and it requires only a minor modification in populations with a specific Y chromosome background. However, in light of novel data on genotype–phenotype correlations, the extension analysis for the AZFa and AZFb deletions is now routinely recommended. Novel methods and kits with excessively high number of markers do not improve the sensitivity of the test, may even complicate the interpretation of the results and are not recommended. Annual participation in an external quality control programme is strongly encouraged. The 12

  15. Sperm midpiece apoptotic markers: impact on fertilizing potential in in vitro fertilization and intracytoplasmic sperm injection.

    Science.gov (United States)

    Talarczyk-Desole, Joanna; Kotwicka, Małgorzata; Jendraszak, Magdalena; Pawelczyk, Leszek; Murawski, Marek; Jędrzejczak, Piotr

    2016-04-01

    The aim of this study was to investigate the relationship between apoptotic markers present in human spermatozoa, namely phosphatidylserine translocation (PST) from the inner to the outer layer of the cytomembrane and the active form of caspase-3 (c3) versus the fertilizing potential of male gametes in conventional in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) models. A total of 116 male patients treated with their partners for infertility underwent basic semen analysis and an assessment of the presence of PST and the active c3 in sperm using flow cytometry. Forty patients underwent IVF, group A, while 76 patients underwent ICSI, group B. The fertilizing potential of the gametes was measured as the percentage of oocytes with pronuclei present after either procedure. PST and active c3 were identified in vital gametes, mainly in the midpiece area. Concentration, motility, morphology, and viability of spermatozoa strongly negatively correlated with both markers. In group A, a negative correlation between both markers and the success rate of conventional IVF was observed (r = -0.4, p = 0.04 for PST; r = -0.4, p = 0.02 for active c3, respectively). In group B, the success rate of ICSI did not correlate with either marker (r = -0.2, p = 0.85 for PST and r = 0.1, p = 0.51 for active c3). The two apoptotic markers localized in the sperm midpiece area may affect their function not only by decreasing basic andrologic parameters but also by reducing the probability of conception. Therefore, analysis of PST and active c3 in the sperm of patients undergoing infertility treatment should be recommended. PMID:26791536

  16. Emerging treatments for premature ejaculation: focus on dapoxetine

    Directory of Open Access Journals (Sweden)

    Wayne JG Hellstrom

    2008-12-01

    Full Text Available Wayne JG HellstromChief, Section of Andrology, Department of Urology, Tulane University School of Medicine, New Orleans, LA, USAAbstract: Premature ejaculation (PE is a common problem in men worldwide. It has a significant impact on affected men and their partners in terms of self-esteem, dissatisfaction with their sexual relationships, personal distress, and interpersonal difficulty. Psychological therapies may achieve short-term improvements, but there are limited data on the long-term success of these methods. Oral therapy with long-acting selective serotonin reuptake inhibitors (SSRIs improves intravaginal ejaculatory latency time (IELT, but these agents are designed to be administered daily and may be associated with unwanted sexual side effects and withdrawal symptoms upon abrupt discontinuation. Dapoxetine is a short-acting SSRI that can be taken as needed (prn by men with PE. It has been studied in five separate multicenter, randomized, double-blind, placebo-controlled trials involving more than 6000 men with PE. In four studies that evaluated IELT as an endpoint (N = 4843, dapoxetine 30 and 60 mg prn achieved statistically significant increases in IELT versus placebo. Dapoxetine also showed statistically significant improvements in perceived control over ejaculation, PE-related personal distress, and other patient-reported outcomes in all five trials. Dapoxetine treatment is generally well-tolerated, with low incidences of discontinuation syndrome, sexual dysfunction, and treatment-emergent mood symptoms. The most common adverse events with dapoxetine included nausea, diarrhea, headache, dizziness, and somnolence.Keywords: dapoxetine, discontinuation syndrome, premature ejaculation, selective serotonin reuptake inhibitor

  17. Prevalence, psychological impact, and risk factors of erectile dysfunction in patients with Peyronie's disease: a retrospective analysis of 309 cases.

    Science.gov (United States)

    Paulis, Gianni; Romano, Gennaro; Paulis, Andrea

    2016-01-01

    Peyronie's disease (PD) is a chronic inflammatory disease involving the tunica albuginea of the penis. Erectile dysfunction (ED) is a possible invalidating symptom of PD. The aim of this study was to evaluate the prevalence, psychological impact, and risk factors of ED in patients with PD. The study was conducted by carrying out a retrospective analysis of the clinical records of 309 patients with PD who visited our andrology clinic. All patients underwent the following tests: body mass index, common blood tests and hormone assays, questionnaire for erectile function assessment, dynamic penile color Doppler ultrasonography, imaging of the penis at maximum erection with photographic poses according to Kelâmi, psychosexual impact evaluation with PD Questionnaire (symptom bother score), evaluation of depression symptoms with the Patient Health Questionnaire-9, and evaluation of the intensity of penile pain with the pain intensity numeric rating scale. ED was observed in 37.5% of the cases. We divided the cases into two groups: group A (PD + ED), 116 cases, and group B (PD without ED), 193 cases. After multivariate analysis, we concluded that the following comorbidities are independent risk factors for ED: dyslipidemia, obesity, chronic prostatitis, benign prostatic hyperplasia, and autoimmune diseases. A depressive disorder was observed in 62.4%, and it was more frequent in patients with PD + ED (91.37% versus 45.07% group B). Sexual bother was greater in group A compared with group B (9.7 versus 7.6). Intensities of depressive symptoms and sexual bother were significantly higher compared with cases with no curvature when the bend angle was ≥30°. Our study confirms that an integrated psychological support with medical treatment is needed in patients with PD. PMID:27486570

  18. Profile of men's health in Malaysia: problems and challenges%马来西亚男性健康的概述:问题与挑战

    Institute of Scientific and Technical Information of China (English)

    Seng Fah Tong; Wah Yun Low; Chirk Jenn Ng

    2011-01-01

    Men's health concerns have evolved from the traditional andrology and male sexual health to a more holistic approach that encompasses male psychological, social and physical health. The poor state of health in men compared to their female counterparts is well documented. A review of the epidemiological data from Malaysia noted a similar trend in which men die at higher rates in under 1 and above 15 years old groups and most disease categories compared to women. In Malaysia, the main causes of death in men are non-communicable diseases and injuries. Risk factors, such as risk-taking behaviour, smoking and hypertension, are prevalent and amenable to early interventions. Erectile dysfunction, premature ejaculation and prostate disorders are also prevalent. However, many of these morbidities go unreported and are not diagnosed early; therefore, opportunities for early intervention are missed. This reflects poor health knowledge and inadequate health-care utilisation among Malaysian men. Their health-seeking behaviour has been shown to be strongly influenced by family members and friends. However, more research is needed to identify men's unmet health-care needs and to develop optimal strategies for addressing them. Because the Malaysian population is aging and there is an increase in sedentary lifestyles, optimizing men's health will remain a challenge unless effective measures are implemented. The existing male-unfriendly health-care system and the negative influence of masculinity on men's health behaviour must be addressed. A national men's health policy based on a male-friendly approach to health-care delivery is urgently needed to provide a framework for addressing these challenges.

  19. Elevated Dihydrotestosterone is Associated with Testosterone-Induced Erythrocytosis

    Science.gov (United States)

    Aghazadeh, Monty; Pastuszak, Alexander W.; Johnson, William G.; McIntyre, Matthew G.; Hsieh, T. Mike; Lipshultz, Larry I.

    2015-01-01

    INTRODUCTION Erythrocytosis is the most common dose-limiting adverse effect of testosterone therapy (TTh), but the mechanisms of T-mediated erythropoiesis remain unclear. In this study, we examine risk factors for erythrocytosis associated with TTh. METHODS Retrospective review of 179 hypogonadal men on TTh in a single andrology clinic was performed. Demographic data, TTh formulation and duration of treatment, and 5α reductase inhibitor (5ARI) use were assessed. Serum dihydrotestosterone (DHT), total T (TT), free T (FT), follicle stimulating hormone (FSH), luteinizing hormone (LH), Hematocrit (Hct), and lipid levels were extracted and changes during treatment determined. Spearman’s rank correlation was used to identify relationships between change in Hct (ΔHct) and study variables. RESULTS Of 179 patients, 49 (27%) developed a ≥10% ΔHct and 36 (20.1%) developed erythrocytosis (Hct ≥50%) at a median follow-up of 7 months. Topical gels were used by 41.3% of patients, injectable T by 52.5%, and subcutaneous pellets by 6.1%. More men who developed ΔHct ≥10% used injectable T than men with ΔHct 5ARI (2% vs. 15%, p=0.017). Men with ΔHct ≥10% had higher post-treatment DHT levels (605.0 vs. 436.0 ng/dL, p=0.017) and lower LH and FSH levels than men with ΔHct <10%. Spearman’s rank correlations yielded relationships between ΔHct and post-treatment DHT (ρ=0.258, p=0.001) and TT (ρ=0.171, p=0.023). CONCLUSION DHT may play a role in TTh-related erythrocytosis, and monitoring of DHT levels during TTh should be considered. In men who develop erythrocytosis, 5ARIs may be therapeutic. PMID:25596360

  20. 泰国湿地水牛(Bubalus bubalis)精液质量的季节变化%Seasonal variation in semen quality of swamp buffalo bulls (Bubalus bubalis) in Thailand

    Institute of Scientific and Technical Information of China (English)

    S.Koonjaenak; V.Chanatinart; S.Aiumlamai; T.Pinyopumimintr; H.Rodriguez-Martinez

    2007-01-01

    Aim:To test the hypothesis that season affects the semen quality of swamp buffalo (Bubalus bubalis) bulls used for artificial insemination (AI) under tropical conditions in Thailand, as it does in Bos taurus and Bos indicus. Methods: Clinical and andrological examinations, and monitoring of semen production and quality were carried out on five mature, healthy swamp buffalo AI bulls in Thailand from July 2004 to the end of June 2005. Sperm output, motility, morphology and plasma membrane integrity (PMI) were compared between three seasons of the year (rainy, I.e. July-October; winter, I.e. November-February; and summer, I.e. March-June) with distinct ambient temperature and humidity. Results: All bulls were diagnosed as clinically healthy and with good libido throughout the study. Ejaculate volume, pH, sperm concentration, total sperm number and initial sperm motility did not differ between seasons, whereas PMI and the relative proportion of morphologically normal spermatozoa were highest in summer and lowest in winter (P < 0.05). Buffalo age, week of collection and season influenced sperm morphology (P < 0.05-0.001). Among morphological abnormalities,only proportions of tail defects were affected by season, being highest in the rainy season and lowest in summer (P<0.001). In conclusion, climatic changes did not seem to largely affect semen sperm output or viability. Although the proportions of PMI and tail abnormalities were affected by season, they were always below what is considered unacceptable for AI bull sires. Conclusion: Seasonal changes did not appear to cause deleterious changes in sperm quality in swamp buffalo AI-sires in tropical Thailand.

  1. A randomized, controlled, multicenter contraceptive efifcacy clinical trial of the intravas device, a nonocclusive surgical male sterilization

    Institute of Scientific and Technical Information of China (English)

    WenHong Lu; XiaoWei Liang; YiQun Gu; WeiXiong Wu; LiWei Bo; TianGui Zheng; ZhenWen Chen

    2014-01-01

    Because of unavoidable complications of vasectomy, this study was undertaken to assess the efifcacy and safety of male sterilization with a nonobstructive intravas device (IVD) implanted into the vas lumen by a mini-surgical method compared with no-scalpel vasectomy (NSV). IVDs were categorized into two types:IVD-B has a tail used for ifxing to the vas deferens (ifxed wing) whereas IVD-A does not. A multicenter prospective randomized controlled clinical trial was conducted in China. The study was comprised of 1459 male volunteers seeking vasectomy who were randomly assigned to the IVD-A (n= 487), IVD-B (n= 485) or NSV (n=487) groups and underwent operation. Follow-up included visits at the 3rd-6th and 12th postoperative months. The assessments of the subjects involved regular physical examinations (including general and andrological examinations) and semen analysis. The subjects’ partners also underwent monitoring for pregnancy by monthly interviews regarding menstruation and if necessary, urine tests. There were no signiifcant differences in pregnancy rates (0.65% for IVD-A, 0 for IVD-B and 0.21% for NSV) among the three groups (P>0.05). The cumulative rates of complications at the 12th postoperative month were zero, 0.9%and 1.7%in the three groups, respectively. In conclusion, IVD male sterilization exhibits a low risk of long-term adverse events and was found to be effective as a male sterilization method, similar to the NSV technique. IVD male sterilization is expected to be a novel contraceptive method.

  2. Theoretic discussion on treatment of chronic prostratitis based on liver (Gan) of TCM%从肝论治慢性前列腺炎的理论探讨

    Institute of Scientific and Technical Information of China (English)

    张春和

    2012-01-01

    Chronic prostatitis ( CP ) is a common disease of urology and andrology. It seriously impacts the physical and mental health of the patients, because it frequently recured and can not be cured completely. According to the clinical characteristic of CP, we found that the pathogenesises of traditional Chinese medicine ( TCM ) are closely related to liver ( Gan ). Because the liver channel named in TCM is distributed at external genitalia area, Qi stagnation of liver, dampness-heat of liver channel and coldness accumulation in liver channel are the main pathogenesises of CP. Thus the treatment of CP with TCM should be aimed at liver. The treatment principles of CP in TCM include relieving depressing of liver, relieving stagnation of liver, dispelling the heat of liver, nourishment of liver blood, warming channel of liver, etc. Moreover, psychological counseling is also a treatment method for patients with CP. There is a clincial significance to treat patients with CP from liver in clinical practice of TCM.%慢性前列腺炎是泌尿男科的常见多发病,其病程迁延难愈、常反复发作,严重影响着患者的身心健康.根据慢性前列腺炎的临床特点,其发病与肝的关系尤为密切.因肝司阴器,肝郁气滞、肝经湿热、寒凝肝脉是引起慢性前列腺炎的重要病机.治疗慢性前列腺炎应责之于肝,治法包括疏肝气、解肝郁、清肝热、养肝血、温肝经等,同时应重视对患者的心理疏导.从肝论治慢性前列腺炎有着重要的临床意义.

  3. [Causes and Factors of Male Infertility].

    Science.gov (United States)

    Kolesnikova, L I; Kolesnikov, S I; Kurashova, N A; Bairova, T A

    2015-01-01

    The preservation of reproductive health of the population is an important factor of demographic policy of the state. According to some authors from 14 to 30% of couples of reproductive age suffer from infertility, malefactor in such marriages is detected in more than half of the cases. As you know, in recent years there has been a significant deterioration in the main indicators of reproductive function of men. Increased the number of andrological diseases, morphological disorders of the male reproductive system, almost halved the production of sperm in men of reproductive age. The reason probably lies behind a whole range ofstressfactors, such as medical ignorance, uncontrolled and inappropriate use of medication, metabolic disturbances, lack of vitamins and minerals, the impact of industrial pollutants, as well as the growth of addictive disorders (alcoholism, smoking and drug addiction). The forms of infertility differ according to its etiology and severity from minor changes to complete spermatogenesis dysfunction of the gonads, and can also occur due to genetic disorders. The lack of analysis of the relationship between clinical and genetic-biochemical components in men with infertility makes it impossible to understand the pathogenesis of infertility and to assess the risks of male infertility. High level of current medicine does not always guarantee an identification of the cause of male infertility. The article analyzes data from the review of specialized literature on the diagnosis and etiopathogenesis of male infertility. Frequency and clinical signs of pathology of the male reproductive system depend on the combinatorial effects of environmental influences, manifested most often in mutually reinforcing effect. A combination of several, seemed to be imperceptible factors makes the risk of development of male reproductive pathology very high. This situation compels specialists to conduct comprehensive studies on the men reproductive potential. PMID

  4. Acquired undescended testes and fertility potential: is orchiopexy at diagnosis better than awaiting spontaneous descent?

    Science.gov (United States)

    van der Plas, E M; van Brakel, J; Meij-de Vries, A; de Muinck Keizer-Schrama, S M P F; Hazebroek, F W J; Hack, W W M; Dohle, G R

    2015-07-01

    The aim of this study was to evaluate testicular function in men with previous acquired undescended testis (UDT) in whom orchiopexy was performed at diagnosis compared with a similar group of men in whom spontaneous descent was awaited until puberty. Secondly, we examined the influence of age at orchiopexy on fertility parameters in adult life. A total of 169 men of the 'orchiopexy at diagnosis' group and 207 men of the 'wait and see' protocol group were invited for participation. All participants underwent an andrological evaluation, including medical history, physical examination, scrotal ultrasound, determination of reproductive hormones, and semen analysis. Results were compared for men in whom orchiopexy was performed at diagnoses with men in whom spontaneous descent was awaited until puberty followed by orchiopexy in case of non-descent. In the 'orchiopexy at diagnosis' group, 63 men of whom 14 with bilateral UDT, and in the 'wait and see' protocol group, 65 men of whom 15 with bilateral UDT were included. For unilateral UDT Inhibin B was found to be significantly lower and median progressive motility was higher in men with orchiopexy at diagnosis. For bilateral UDT, semen concentration and progressive motility showed a trend toward a favorable outcome for orchiopexy at diagnosis. Age at orchiopexy being under or above 10 years of age had no significant influence on the fertility potential. The outcome of physical examination, scrotal ultrasound, endocrine function, and semen analysis indicates a compromised fertility potential in men with previous acquired UDT. None of the protocols proved to be superior. For bilateral UDT, a trend toward favorable outcome of orchiopexy at diagnosis was seen. Furthermore, age at orchiopexy did not have an influence on fertility parameters. Therefore, in our opinion a 'conservative policy' is warranted for unilateral UDT, especially because over 50% of acquired UDT descend spontaneously. PMID:26084887

  5. Current updates on laboratory techniques for the diagnosis of male reproductive failure

    Science.gov (United States)

    Sikka, Suresh C; Hellstrom, Wayne JG

    2016-01-01

    The incidence of male reproductive failure leading to infertility, whether due to delayed parenthood, environmental issues, genetic factors, drugs, etc., is increasing throughout the world. The diagnosis and prognosis of male subfertility have become a challenge. While the basic semen assessment has been performed for many years, a number of studies question the value of the traditional semen characteristics. This is partly due to inadequate methods and standardization, limited knowledge of technical requirements for quality assurance, and an incomplete understanding of what clinical information a semen assessment can provide. Laboratories currently performing semen and endocrine assessment show great variability. The World Health Organization (WHO) manual for the evaluation of semen has been the core of andrology and fertility evaluation that has helped in further development of this field over many years. These include the physical appearance of the ejaculate, assessments of sperm count, motility, vitality, morphology, and functional aspects of the sperm and semen sample. These tests also include male endocrine profile, biochemical evaluation of the semen, detection of antisperm antibodies in serum, the use of computer-aided sperm analysis (CASA), sperm DNA integrity, and its damage due to oxidative stress. Assisted reproductive techniques (e.g., IVF, ICSI) have shown great success but are too expensive. Further development in this field with newer techniques and extensive training/instructions can improve accuracy and reduce variability, thus maintaining the quality and standards of such an evaluation. There is an urgent need to have standardized training centers and increased awareness in this area of men's health for reproductive success. PMID:27056346

  6. La Estimulación Vibratoria del Pene (EVP, Alternativa Novedosa y no Invasiva para la Obtención de Semen en Primates y otras Especies Animales

    Directory of Open Access Journals (Sweden)

    Robin Poches-Franco

    2010-10-01

    Full Text Available A nivel mundial en diversas especies animales domésticas y silvestres, se lleva a cabo la colecta y evaluación de las características seminales con distintos objetivos, como son el conocimiento preliminar de la biología reproductiva (andrología, criopreservación de gametos, inseminación artificial entre otros. Para obtener semen se dispone de diversas técnicas; entre estos están; la electroeyaculación por sonda bipolar rectal o por estimulación directa del pene, la masturbación, la automasturbación, la punción epidídimal, el lavado vaginal post-eyaculación, vagina artificial y la Estimulación Vibratoria del Pene (EVP. Esta ultima (EVP una de las más novedosas y no invasivas que últimamente ha ganado terreno con el FertiCare® personal vibrator, ya que no representa mayores consecuencias a los animales muestreados, su adquisición no es costosa comparada con los electroeyaculadores, apenas mide 20cm de largo y pesa 285gr, y como mayor ventaja en cuanto a viabilidad y concentración de espermatozoides, la cual es mayor en aquellos métodos no invasivos como la masturbación, la vagina artificial y la estimulación vibratoria del pene, claro que esta ultima tiene una gran ventaja y es el control para evitar la contaminación por bacterias o aditivos (talcos o resinas de látex en vaginas artificiales del semen, por consiguiente la calidad de la muestra seminal obtenida es mucho mayor.

  7. Improved human sperm recovery using superoxide dismutase and catalase supplementation in semen cryopreservation procedure.

    Science.gov (United States)

    Rossi, T; Mazzilli, F; Delfino, M; Dondero, F

    2001-01-01

    The aim of this work was to evaluate the effects of ROS scavenger supplementation in human semen samples undergoing cryopreservation procedures.After screening out andrological pathologies, we selected 25 male partners of infertile couples with the following semen profile: volume >/= 2.0 ml, normal viscosity, sperm count >/=20 x 10(6)/ml, straight progressive motility (classes 1 and 2) >/= 40% (Mazzilli, Rossi, Delfino and Nofroni (1999) Andrologia 31: 187-194), atypical forms semen analysis and the Hypoosmotic Viability Test (HVT) were carried out; the samples were then divided into 4 aliquots. The first was untreated as a control; 200 U/ml of superoxide dismutase (SOD) was added to the second, 200 U/ml of catalase to the third and both SOD (100 U/ml) and catalase (100 U/ml) were added to the fourth aliquot. Each aliquot was mixed (v/v) with TEST yolk buffer freezing medium (Irvine Scientific) and then frozen at -196 degrees C. The percent recovery of progressive motile and swollen spermatozoa was evaluated after thawing.No significant variation in the recovery of progressive motility was seen in the aliquots with added SOD or catalase alone, compared to the control group. On the other hand, a significant improvement in sperm parameter recovery was seen in the aliquot with both SOD and catalase supplementation; perhaps because of their combined and simultaneous action on superoxide anion and hydrogen peroxide. These results suggest that, in some selected cases, SOD and catalase supplementation can contribute greatly to the prevention of sperm membrane lipid peroxidation by ROS and thus allow good sperm parameter recovery after freezing-thawing procedures. PMID:15256925

  8. [Treatment of male genital infections with enoxacin].

    Science.gov (United States)

    Giorgi, P M; Giorgi, P; Canale, D; Turchi, P; Poggi, M S; Di Coscio, M; Bartelloni, M; Meschini, P; Andreini, F; Campa, M

    1989-09-01

    Inflammatory disease such as prostatitis and prostatovesiculitis, can affect the fertility potential of the male population. In this study, the Authors tested the therapeutical efficacy of a second generation quinolone, enoxacin, in patients suffering from vesicular and/or prostatic inflammations. This drug has been shown to diffuse into the prostatic fluid, achieving therapeutical concentrations either in acute or chronic pathological conditions. Thirty infertile patients referring to our Andrology Center and showing seminal signs (leukocytes, abnormal sperm forms, chemical and physical alterations, etc) of genital tract inflammations were found to have positive sperm culture for enoxacin-sensitive strains. Further investigations (echotomography) showed that they were affected by prostatic and/or vesicular subacute chronic inflammations. The mean age was 32.2 (range 20-36) ys. All the patients discontinued any previous treatment for at least 90 days. Enoxacin was administered at the dose of 300 mg b.i.d. for two cycles of 10 days each, with intervals of 20 days. At the beginning and at the end of the treatment (days 0 and 60), semen analysis and culture were performed. A paired-T test was employed for the statistical evaluation of data. 26.6% of patients ad an altered fluidification before treatment. Only 10.0% of them showed the same sign after treatment. A condition of hyperviscosity was present in 50% and 16.6% of patients before and after treatment respectively. Likewise, an elevated number of leukocytes (greater than 10(6)/ml) occurred in the ejaculates of 43.3% of patients and in 23.3% after enoxacin treatment. Enoxacin treatment was efficacious in 89.2% of cases, in presence of either Gram positive or Gram negative bacteria.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:2529639

  9. [Celiac disease and its endocrine and nutritional implications on male reproduction].

    Science.gov (United States)

    Stazi, A V; Mantovani, A

    2004-06-01

    The problem of the interference of celiac disease (CD) with the male reproductive system is made evident both by the recognized adverse effects on female reproduction and by the multifactorial nature of the disease. It is important to consider CD as a multifactorial condition since its diverse effects can be modulated, besides gluten, by different concurrent genetic and environmental factors. The male CD patient has a greater risk of infertility and other reproductive disturbances, as well as a greater incidence of hypoandrogenism. In this paper the problems of CD associated to endocrine disorders and to deficiencies of micronutrients are discussed. Affected males show a picture of tissue resistance to androgens. Moreover, attention should be paid to increases of FSH and prolactin; these are not associated to infertility and/or impotence, but they may indicate an imbalance at hypothalamus-pituitary level, with general effects on health: an example is the increased risk of male osteoporosis in CD patients. Hormone alterations are reversible upon start of the gluten-free diet, emphasizing the importance of early diagnosis; this should be performed in the case of clinical suspicion, e.g., unexplained hypoandrogenism. As regards nutritional aspects, the folic acid deficiency of CD can affect rapidly proliferating tissues, such as the embryo and the seminiferous epithelium. More attention should be paid to deficiencies of fat-soluble vitamins, such as A and E, observed in CD. Vitamin A is important for Sertoli cell function as well as for early spermatogenetic phases. Vitamin E supports the correct differentiation and function of epidydimal epithelium, spermatid maturation and secretion of proteins by the prostate. Therefore, CD male patients should be considered as vulnerable subjects; thus, the detection of early biomarkers of andrological or endocrinological dysfunctions should trigger timely strategies for prevention and treatment. PMID:15289752

  10. Penile prosthesis surgery in out-patient setting: Effectiveness and costs in the “spending review” era

    Directory of Open Access Journals (Sweden)

    Nicola Mondaini

    2014-09-01

    Full Text Available Introduction: Penile implant patients are required to remain in the hospital after the operation for monitoring, antibiotic and analgesia administration. Cost containment, however, has resulted in the increased use of ambulatory surgery settings for many surgical procedures. Few studies have studied the feasibility of performing penile prosthesis insertion in an outpatient setting. The results are controversial and nowadays, in the most of centers that deal with prosthetic surgery, patients are still hospitalized. Aim: The aim of our investigation was to compare the feasibility of the performance as well as the complication profiles of penile implant surgery performed in an in-patient and an outpatient setting at a single center by a single surgeon. Methods: From January 2009 to June 2014, 50 patients of the same uro-andrological unit underwent penile prosthesis implantation performed by a single surgeon (N.M.. Twenty implantations were performed in an ambulatory day surgery setting. Main outcome measures: Effectiveness and costs of outpatient setting versus the in-patient setting of the penile prosthesis surgery. Results: There were some differences between the two groups in the intra-operative parameters, such as, operating time. Time lost from work was similar in both groups approximating 14 days. The mean number of analgesic pills ingested by the patients post-operatively was similar in both groups, averaging just under 25 pills per patient. There weren’t post-operative complications in the outpatient group. Cost were 17% less in outpatient clinic. Conclusions: The outpatient setting for this surgery is safe and effective even in patients with comorbidities or in case of secondary procedures. Costs are reduced by 17%.

  11. Current updates on laboratory techniques for the diagnosis of male reproductive failure.

    Science.gov (United States)

    Sikka, Suresh C; Hellstrom, Wayne Jg

    2016-01-01

    The incidence of male reproductive failure leading to infertility, whether due to delayed parenthood, environmental issues, genetic factors, drugs, etc., is increasing throughout the world. The diagnosis and prognosis of male subfertility have become a challenge. While the basic semen assessment has been performed for many years, a number of studies question the value of the traditional semen characteristics. This is partly due to inadequate methods and standardization, limited knowledge of technical requirements for quality assurance, and an incomplete understanding of what clinical information a semen assessment can provide. Laboratories currently performing semen and endocrine assessment show great variability. The World Health Organization (WHO) manual for the evaluation of semen has been the core of andrology and fertility evaluation that has helped in further development of this field over many years. These include the physical appearance of the ejaculate, assessments of sperm count, motility, vitality, morphology, and functional aspects of the sperm and semen sample. These tests also include male endocrine profile, biochemical evaluation of the semen, detection of antisperm antibodies in serum, the use of computer-aided sperm analysis (CASA), sperm DNA integrity, and its damage due to oxidative stress. Assisted reproductive techniques (e.g., IVF, ICSI) have shown great success but are too expensive. Further development in this field with newer techniques and extensive training/instructions can improve accuracy and reduce variability, thus maintaining the quality and standards of such an evaluation. There is an urgent need to have standardized training centers and increased awareness in this area of men's health for reproductive success. PMID:27056346

  12. A randomized, controlled, multicenter contraceptive efficacy clinical trial of the intravas device, a nonocclusive surgical male sterilization

    Directory of Open Access Journals (Sweden)

    Wen-Hong Lu

    2014-06-01

    Full Text Available Because of unavoidable complications of vasectomy, this study was undertaken to assess the efficacy and safety of male sterilization with a nonobstructive intravas device (IVD implanted into the vas lumen by a mini-surgical method compared with no-scalpel vasectomy (NSV. IVDs were categorized into two types: IVD-B has a tail used for fixing to the vas deferens (fixed wing whereas IVD-A does not. A multicenter prospective randomized controlled clinical trial was conducted in China. The study was comprised of 1459 male volunteers seeking vasectomy who were randomly assigned to the IVD-A (n = 487, IVD-B (n = 485 or NSV (n = 487 groups and underwent operation. Follow-up included visits at the 3 rd -6 th and 12 th postoperative months. The assessments of the subjects involved regular physical examinations (including general and andrological examinations and semen analysis. The subjects' partners also underwent monitoring for pregnancy by monthly interviews regarding menstruation and if necessary, urine tests. There were no significant differences in pregnancy rates (0.65% for IVD-A, 0 for IVD-B and 0.21% for NSV among the three groups (P > 0.05. The cumulative rates of complications at the 12 th postoperative month were zero, 0.9% and 1.7% in the three groups, respectively. In conclusion, IVD male sterilization exhibits a low risk of long-term adverse events and was found to be effective as a male sterilization method, similar to the NSV technique. IVD male sterilization is expected to be a novel contraceptive method.

  13. Current updates on laboratory techniques for the diagnosis of male reproductive failure

    Directory of Open Access Journals (Sweden)

    Suresh C Sikka

    2016-01-01

    Full Text Available The incidence of male reproductive failure leading to infertility, whether due to delayed parenthood, environmental issues, genetic factors, drugs, etc., is increasing throughout the world. The diagnosis and prognosis of male subfertility have become a challenge. While the basic semen assessment has been performed for many years, a number of studies question the value of the traditional semen characteristics. This is partly due to inadequate methods and standardization, limited knowledge of technical requirements for quality assurance, and an incomplete understanding of what clinical information a semen assessment can provide. Laboratories currently performing semen and endocrine assessment show great variability. The World Health Organization (WHO manual for the evaluation of semen has been the core of andrology and fertility evaluation that has helped in further development of this field over many years. These include the physical appearance of the ejaculate, assessments of sperm count, motility, vitality, morphology, and functional aspects of the sperm and semen sample. These tests also include male endocrine profile, biochemical evaluation of the semen, detection of antisperm antibodies in serum, the use of computer-aided sperm analysis (CASA, sperm DNA integrity, and its damage due to oxidative stress. Assisted reproductive techniques (e.g., IVF, ICSI have shown great success but are too expensive. Further development in this field with newer techniques and extensive training/instructions can improve accuracy and reduce variability, thus maintaining the quality and standards of such an evaluation. There is an urgent need to have standardized training centers and increased awareness in this area of men′s health for reproductive success.

  14. Impact of Cystic Fibrosis Transmembrane Regulator (CFTR gene mutations on male infertility

    Directory of Open Access Journals (Sweden)

    Jlenia Elia

    2014-09-01

    Full Text Available Objective. The aim of this study was to evaluate the prevalence of most common mutations and intron 8 5T (IVS8-5T polymorphism of CFTR gene in Italian: a azoospermic males; b non azoospermic subjects, male partners of infertile couples enrolled in assisted reproductive technology (ART programs. Material and methods. We studied 242 subjects attending our Andrology Unit (44 azoospermic subjects and 198 non azoospermic subjects, male partners of infertile couples enrolled in ART programs. Semen analysis, molecular analysis for CFTR gene mutations and genomic variant of IVS8-5T polymorphic tract, karyotype and chromosome Y microdeletions, hormonal profile (LH, FSH, Testosterone and seminal biochemical markers (fructose, citric acid and L-carnitine were carried out. Results. The prevalence of the common CFTR mutations and/or the IVS8-5T polymorphism was 12.9% (4/31 cases in secretory azoospermia, while in obstructive azoospermia was 84.6% (11/13 cases; in these, the most frequent mutations were the F508del, R117H and W1282X. Regarding the non azoospermic subjects, the prevalence of the CFTR and/or the IVS8-5T polymorphism was 11.1% (11/99 cases in severe dyspermia, 8.1% (6/74 cases in moderate dyspermia and finally 4.0% (1/25 cases in normospermic subjects. Conclusions. This study confirms the highly significant prevalence of CFTR mutations in males with bilateral absence of the vas deferens or ejaculatory ducts obstruction compared with subjects with secretory azoospermia. Moreover, the significant prevalence of mutations in severely dyspermic subjects may suggest the possible involvement of CFTR even in the spermatogenic process. This could explain the unsatisfactory recovery of sperm from testicular fine needle aspiration in patients affected by genital tract blockage.

  15. AVALIAÇÃO ULTRASSONOGRAFIA DA ECOGENICIDADE DO PARÊNQUIMA TESTICULAR COMO EXAME COMPLEMENTAR NO ANDROLÓGICO DE CARNEIROS

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    Pedro Paulo Maia Teixeira

    2011-05-01

    Full Text Available O objetivo deste trabalho foi padronizar um método de ultrassonografia para exames do parênquima testicular em andrológicos de carneiros (n=6. Foi realizada biometria testicular, espermiograma e exame ultrassonográfico do parênquima testicular, realizando imagens do parênquima testicular e aferido o percentual de ecogenicidade em pela escala de cinza no próprio aparelho, correlacionando com dados da biometria e espermiograma. Verificaram-se correlações positivas entre a ecogenicidade e a concentraçãoespermática (p=0,0192 e r2= 0,4373 e entre ecogenicidade e motilidade massal (p=0,0358 e r2= 0,37, demonstrando que o método é eficiente para diagnosticar alterações escrotais assintomáticas aos exames convencionais, contribuindo para a reprodução animal.The present study aimed to standardize an ultrasonogram method to testicular parenchyma in andrological sheep (n = 6. We made testicular biometric, spermiogram and testicular parenchymaultrasonography, carrying images of the testicular parenchyma and measured the percentage of the echogenicity in gray scale on the device itself, correlating with the biometrics data and spermiogram. There were positive correlations between echogenicity and sperm concentration (p = 0.0192 and r2 = 0.4373 and betweenechogenicity and mass motility (p = 0.0358 and r2 = 0.37, demonstrating that the method is efficient to detect abnormal scrotal asymptomatic by conventional tests, contributing to animal breeding.

  16. Clinical correlates of enlarged prostate size in subjects with sexual dysfunction

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    Giovanni Corona

    2014-10-01

    Full Text Available Digito-rectal examination (DRE of the prostate provides useful information on the state of prostate growth and on the presence of suspected peripheral nodules. The aim of this study is to describe the clinical and biochemical correlates of finding an enlarged prostate size at DRE in subjects with sexual dysfunction (SD. A consecutive series of 2379 patients was retrospectively studied. The analysis was focused on a subset of subjects (n = 1823; mean age 54.7 ± 11.4 selected for being free from overt prostatic diseases. Several parameters were investigated. After adjusting for confounders, the presence of an enlarged prostate size at DRE was associated with a higher risk of metabolic syndrome (HR = 1.346 (1.129-1.759; P = 0.030, type 2 diabetes mellitus (HR = 1.489 (1.120-1.980; P = 0.006, increased LDL cholesterol (>100 mg dl−1 ; HR = 1.354 (1.018-1.801; P = 0.037 and increased mean blood pressure (BP values (HR = 1.017 (1.007-1.027 for each mmHg increment; P = 0.001. Accordingly, enlarged prostate size was also associated with a higher risk of arteriogenic erectile dysfunction (ED, as well as with other andrological conditions, such as varicocele and premature ejaculation (PE. PSA levels were significantly higher in subjects with enlarged prostate size when compared to the rest of the sample (HR = 3.318 (2.304; 4.799 for each log unit increment in PSA levels; P < 0.0001. Arteriogenic ED, according to different criteria, was also associated with increased PSA levels. In conclusion, our data support the need to examine prostate size either by clinical (DRE or biochemical (PSA inspection in subjects with SD, in order to have insights into the nature of the SD and the metabolic and cardiovascular (CV background of the patient.

  17. 明清时期的男色疾病文献研究%MSM-related STDs in the Ming and Qing dynasty in China

    Institute of Scientific and Technical Information of China (English)

    张杰

    2015-01-01

    Discussions can be seen on the sexually -transmitted diseases related to male homosexuality in the Ming and Qing Dynasty.Based on the conceptions of yin and yang,medical professionals and moralists argued that male homosexuality leads to the intercourse between two yangs,on the top of which the hyperactive yang (kan-gyang)results in diseases.The andrology diseases referred to include turbidity (zhuobing),and malnutrition (gan-bing).The commonly seen diseases related to male homosexuality were vision -impairment,infertility,strength -exhaustion,in which the concept of male homosexual toxin (longyangdu)was particularly prominent.Medical pro-fessionals grounded their pathological reasoning on the basis of moral ideas,by which conclusions were reached prior to their proofs.This is an enlightening illumination of medical idealism.%与男色同性恋相关的疾病在明清时期有所讨论,诸医家及社会道德人士立足于阴阳观念,认为男男性行为是两阳相并,亢阳则诸疾丛至。所言男色男科病包括有浊病、疳病等,由男色引起的普通疾病包括有目损、艰嗣、体虚等,而“龙阳毒”的概念尤其引人瞩目。医家们用道德观念来推断病因,先下结论再找理由,为医学唯心主义提供了一个典型例证。

  18. Successful treatment of severe oligozoospermia with sperm washing and intrauterine insemination.

    Science.gov (United States)

    Centola, G M

    1997-01-01

    During the period January 1, 1991 through December 31, 1995, 258 patients, in whom motile sperm counts for insemination (postwash, processed) were 10.0 million motile sperm or less were seen in the andrology unit for sperm washing and intrauterine insemination (IUI). No significant female factors were noted on history; all female partners had patent Fallopian tubes and were ovulatory spontaneously or were treated by the referring gynecologist with clomiphene citrate, human menopausal gonadotropin (hMG), or follicle-stimulating hormone (FSH) ovulation induction in both anovulatory or ovulatory women. Of the total of 258 patients, 15 achieved a pregnancy in 284 cycles of IUI in which the inseminating motile-count was IUI in this group was 0.61 (+/-0.29) million sperm, with a range of 0.19-0.95 million motile sperm. The initial motile count was 2.97 (3.2) million sperm, with a range of 0.2-12.81 million sperm. With inseminating motile counts of 1.0-10.0 million motile sperm, there were 83 pregnancies after 467 cycles of IUI, resulting in a monthly f of 17.8%. The mean (+/-SD) motile count for IUI in this group was 4.9 (+/-2.7) million motile sperm with a range of 1.0-9.9 million motile sperm. The initial sperm count in this group was 10.9 million (+/-7.1), with a range of 1.1-23.7 million motile sperm. These data suggest that acceptable pregnancy rates can be achieved with IUI, even in severely oligozoospermic specimens. Intrauterine insemination is less invasive and less costly than other assisted reproductive techniques. These data are supportive of IUI prior to attempting other more invasive and potentially costly reproductive technologies. PMID:9283959

  19. 前列腺癌:危及亚洲老年男性健康的恶性肿瘤%Prostate cancer: an emerging threat to the health of aging men in Asia

    Institute of Scientific and Technical Information of China (English)

    Ling Zhang; Bao-Xue Yang; Hai-Tao Zhang; Jin-Guo Wang; Hong-Liang Wang; Xue-Jian Zhao

    2011-01-01

    The aim of this study was to determine and examine the possible reasons for the difference in prostate cancer incidence between Asian men and North American men by literature review. Data regarding cancer incidence and mortality were obtained from the database of the International Agency for Research on Cancer (IARC). A literature review was conducted by studying related articles published in peer-reviewed journals such as the The New England Journal of Medicine, Journal of Clinical Oncology, A Cancer Journal for Clinicians and Asian Journal of Andrology. To evaluate the early diagnosis and survival rates, the mortality-to-incidence rate ratio (MR/IR) was calculated from the IARC data. By comparing prostate cancer data between Asian men and North American men, we found that differences in the incidence rate and MR/IR could be attributed largely to a lack of annual prostate cancer screening with serum prostate-specific antigen (PSA) in most Asian countries. It is likely that PSA screening also contributes significantly to the differences in prostate cancer mortality rates. Prostate cancer has the highest incidence rate among five common malignancies in Asian Americans. However, the MR/IR ratio of prostate cancer is the lowest among cancers. These data seem to further support the usefulness of PSA screening, even though the percentage of low risk cancers is greater in prostate cancer than in other cancers. The low incidence rate of prostate cancer does not reflect the actual statistics of this disease in Asia. The data from limited institutions in many Asian countries seem to bias the true incidence and mortality rates. To improve this situation, incorporating PSA screening for prostate cancer, as well as constructing a nationwide cancer registration system, will be helpful.

  20. Prevalence, psychological impact, and risk factors of erectile dysfunction in patients with Peyronie’s disease: a retrospective analysis of 309 cases

    Science.gov (United States)

    Paulis, Gianni; Romano, Gennaro; Paulis, Andrea

    2016-01-01

    Peyronie’s disease (PD) is a chronic inflammatory disease involving the tunica albuginea of the penis. Erectile dysfunction (ED) is a possible invalidating symptom of PD. The aim of this study was to evaluate the prevalence, psychological impact, and risk factors of ED in patients with PD. The study was conducted by carrying out a retrospective analysis of the clinical records of 309 patients with PD who visited our andrology clinic. All patients underwent the following tests: body mass index, common blood tests and hormone assays, questionnaire for erectile function assessment, dynamic penile color Doppler ultrasonography, imaging of the penis at maximum erection with photographic poses according to Kelâmi, psychosexual impact evaluation with PD Questionnaire (symptom bother score), evaluation of depression symptoms with the Patient Health Questionnaire-9, and evaluation of the intensity of penile pain with the pain intensity numeric rating scale. ED was observed in 37.5% of the cases. We divided the cases into two groups: group A (PD + ED), 116 cases, and group B (PD without ED), 193 cases. After multivariate analysis, we concluded that the following comorbidities are independent risk factors for ED: dyslipidemia, obesity, chronic prostatitis, benign prostatic hyperplasia, and autoimmune diseases. A depressive disorder was observed in 62.4%, and it was more frequent in patients with PD + ED (91.37% versus 45.07% group B). Sexual bother was greater in group A compared with group B (9.7 versus 7.6). Intensities of depressive symptoms and sexual bother were significantly higher compared with cases with no curvature when the bend angle was ≥30°. Our study confirms that an integrated psychological support with medical treatment is needed in patients with PD. PMID:27486570

  1. Impact of Bep or Carboplatin Chemotherapy on Testicular Function and Sperm Nucleus of Subjects with Testicular Germ Cell Tumor

    Science.gov (United States)

    Ghezzi, Marco; Berretta, Massimiliano; Bottacin, Alberto; Palego, Pierfrancesco; Sartini, Barbara; Cosci, Ilaria; Finos, Livio; Selice, Riccardo; Foresta, Carlo; Garolla, Andrea

    2016-01-01

    Young males have testicular germ cells tumors (TGCT) as the most common malignancy and its incidence is increasing in several countries. Besides unilateral orchiectomy (UO), the treatment of TGCT may include surveillance, radiotherapy, or chemotherapy (CT), basing on tumor histology and stage of disease. It is well known that both radio and CT may have negative effects on testicular function, affecting spermatogenesis, and sex hormones. Many reports investigated these aspects in patients treated with bleomycin, etoposide, and cisplatin (BEP), after UO. In contrast no data are available on the side effects of carboplatin treatment in these patients. We included in this study 212 consecutive subjects who undergone to sperm banking at our Andrology and Human Reproduction Unit after UO for TGCT. Hundred subjects were further treated with one or more BEP cycles (BEP-group), 54 with carboplatin (CARB group), and 58 were just surveilled (S-group). All patients were evaluated for seminal parameters, sperm aneuploidy, sperm DNA, sex hormones, volume of the residual testis at baseline (T0) and after 12 (T1) and 24 months (T2) from UO or end of CT. Seminal parameters, sperm aneuploidies, DNA status, gonadic hormones, and testicular volume at baseline were not different between groups. At T1, we observed a significant reduction of sperm concentration and sperm count in the BEP group versus baseline and versus both Carb and S-group. A significant increase of sperm aneuploidies was present at T1 in the BEP group. Similarly, the same group at 1 had altered sperm DNA integrity and fragmentation compared with baseline, S-group and Carb group. These alterations were persistent after 2 years from the end of BEP treatment. Despite a slight improvement at T2, the BEP group had still higher percentages of sperm aneuploidies than other groups. No impairment of sperm aneuploidies and DNA status were observed in the Carb group both after 1 and 2 years from the end of treatment. Despite

  2. 25-Hydroxyvitamin D insufficiency discriminates cardiovascular risk factors accumulation in peri-pubertal boys undergoing overweight screening.

    Science.gov (United States)

    Di Nisio, Andrea; De Toni, Luca; D'Addato, Elvio; Pizzo, Maria R; Sabatino, Pasquale; Foresta, Carlo

    2016-08-01

    The aim of this study was to evaluate the possible association between cardiometabolic risk factors accumulation and vitamin D status in a cohort of Italian normal weight and overweight male children. 108 boys enrolled in an andrological health prevention project underwent physical examination, anthropometric measurements, and fasting blood sampling. Serum blood glucose, HDL-cholesterol, triglycerides, parathyroid hormone, and 25-hydroxyvitamin D (25(OH)D) were measured. Cardiovascular risk factors were defined according to the National Cholesterol Education Program Adult Treatment Panel III modified for age. Lean and overweight subjects differed in terms of waist circumference (P < 0.001), HDL-cholesterol (P = 0.001), triglycerides (P = 0.001), systolic blood pressure (P < 0.001) and diastolic blood pressure (P = 0.002). Both groups had similar mean 25(OH)D levels (P = 0.160) and were below the sufficiency threshold: indeed only 24 % of normal weight had 25(OH)D ≥30 ng/ml, and even less in the overweight/obese group (8 %, P = 0.03 vs. normal weight). A significant accumulation of risk factors in course of 25(OH)D insufficiency was detected in both the whole cohort and in the normal weight group (P = 0.003 and P = 0.04, respectively) with odd ratios of 1.31 (1.16-1.49 95%CI) and 1.41 (1.18-1.69 95%CI), respectively. In course of vitamin D deficiency, the odd ratios were 2.24 (1.34-3.77 95%CI, P = 0.003) in the whole cohort and 2.40 (1.27-4.82 95%CI, P = 0.03) in lean subjects. We reported a considerable occurrence of cardiovascular risk factors in course of hypovitaminosis D in overweight/obese boys and even in lean subjects, which normally would not have been further evaluated by considering the sole BMI-related parameters. In this regard, 25(OH)D levels appear as a potential discriminating parameter able to identify male children at higher health risk. PMID:26323345

  3. Placebo-controlled double-blind randomized trial on the use of L-carnitine, L-acetylcarnitine, or combined L-carnitine and L-acetylcarnitine in men with idiopathic asthenozoospermia

    Directory of Open Access Journals (Sweden)

    Giancarlo Balercia

    2014-12-01

    Full Text Available Objective: To evaluate the effectiveness of L-carnitine (LC or L-acetyl-carnitine (LAC or combined LC and LAC treatment in improving semen kinetic parameters and the total oxyradical scavenging capacity in semen. Design: Placebo-controlled, double-blind, randomized trial.Setting: Andrology unit, Department of Internal Medicine, Polytechnic University of Marche, Italy.Patient(s: Sixty infertile men, ages 20 to 40 years, with the following baseline sperm selection criteria: concentration > 20 × 10 6 / mL, sperm forward motility < 50 %, and normal sperm morphology > 30 %; 59 patients completed the study.Intervention(s: Patients underwent a double-blind therapy of LC 3 g / d, LAC 3 g / d, a combination of LC 2 g / d + LAC 1 g / d, or placebo. The study design was 1 month of run in, 6 months of therapy or placebo, and 3 months of follow-up evaluation.Main Outcome Measure(s: Variations in semen parameters used for patient selection, and variations in total oxyradical scavenging capacity of the seminal fluid.Result(s: Sperm cell motility (total and forward, including kinetic features determined by computer-assisted sperm analysis increased in patients to whom LAC was administered both alone or in combination with LC; combined LC + LAC therapy led to a significant improvement of straight progressive velocity after 3 months. The total oxyradical scavenging capacity of the semen toward hydroxyl and peroxyl radicals also increased and was positively correlated with the improvement of kinetic features. Patients with lower baseline values of motility and total oxyradical scavenging capacity of the seminal fluid had a significantly higher probability of responding to the treatment.Conclusion(s: The administration of LC and LAC is effective in increasing sperm kinetic features in patients affected by idiopathic asthenozoospemia and improves the total oxyradical scavenging capacity of the seminal fluid in the same population (Fertil Steril ® 2005;84:662–71

  4. Impact of Bep or Carboplatin Chemotherapy on Testicular Function and Sperm Nucleus of Subjects with Testicular Germ Cell Tumor.

    Science.gov (United States)

    Ghezzi, Marco; Berretta, Massimiliano; Bottacin, Alberto; Palego, Pierfrancesco; Sartini, Barbara; Cosci, Ilaria; Finos, Livio; Selice, Riccardo; Foresta, Carlo; Garolla, Andrea

    2016-01-01

    Young males have testicular germ cells tumors (TGCT) as the most common malignancy and its incidence is increasing in several countries. Besides unilateral orchiectomy (UO), the treatment of TGCT may include surveillance, radiotherapy, or chemotherapy (CT), basing on tumor histology and stage of disease. It is well known that both radio and CT may have negative effects on testicular function, affecting spermatogenesis, and sex hormones. Many reports investigated these aspects in patients treated with bleomycin, etoposide, and cisplatin (BEP), after UO. In contrast no data are available on the side effects of carboplatin treatment in these patients. We included in this study 212 consecutive subjects who undergone to sperm banking at our Andrology and Human Reproduction Unit after UO for TGCT. Hundred subjects were further treated with one or more BEP cycles (BEP-group), 54 with carboplatin (CARB group), and 58 were just surveilled (S-group). All patients were evaluated for seminal parameters, sperm aneuploidy, sperm DNA, sex hormones, volume of the residual testis at baseline (T0) and after 12 (T1) and 24 months (T2) from UO or end of CT. Seminal parameters, sperm aneuploidies, DNA status, gonadic hormones, and testicular volume at baseline were not different between groups. At T1, we observed a significant reduction of sperm concentration and sperm count in the BEP group versus baseline and versus both Carb and S-group. A significant increase of sperm aneuploidies was present at T1 in the BEP group. Similarly, the same group at 1 had altered sperm DNA integrity and fragmentation compared with baseline, S-group and Carb group. These alterations were persistent after 2 years from the end of BEP treatment. Despite a slight improvement at T2, the BEP group had still higher percentages of sperm aneuploidies than other groups. No impairment of sperm aneuploidies and DNA status were observed in the Carb group both after 1 and 2 years from the end of treatment. Despite

  5. IMPACT OF BEP OR CARBOPLATIN CHEMOTHERAPY ON TESTICULAR FUNCTION AND SPERM NUCLEUS OF SUBJECTS WITH TESTICULAR GERM CELL TUMOR

    Directory of Open Access Journals (Sweden)

    Marco eGhezzi

    2016-05-01

    Full Text Available Young males have testicular germ cells tumours (TGCT as the most common malignancy and its incidence is increasing in several countries. Besides unilateral orchiectomy (UO, the treatment of TGCT may include surveillance, radiotherapy or chemotherapy (CT, basing on tumour histology and stage of disease. It is well known that both radio and CT may have negative effects on testicular function, affecting spermatogenesis and sex hormones. Many reports investigated these aspects in patients treated with bleomycin, etoposide and cisplatin (BEP, after UO. In contrast no data are available on the side effects of carboplatin treatment in these patients. We included in this study 212 consecutive subjects who undergone to sperm banking at our Andrology and Human Reproduction Unit after UO for TGCT. Hundred subjects were further treated with one or more BEP cycles (BEP-group, 54 with carboplatin (Carb group and 58 were just surveilled (S-group. All patients were evaluated for seminal parameters, sperm aneuploidy, sperm DNA, sex hormones, volume of the residual testis at baseline (T0 and after 12 (T1 and 24 months (T2 from UO or end of CT. Seminal parameters, sperm aneuploidies, DNA status, gonadic hormones and testicular volume at baseline were not different between groups. At T1 we observed a significant reduction of sperm concentration and sperm count in the BEP group versus baseline and versus both Carb and S- group. A significant increase of sperm aneuploidies was present at T1 in the BEP group. Similarly, the same group at 1 had altered sperm DNA integrity and fragmentation compared with baseline, S group and Carb group. These alterations were persistent after two years from the end of BEP treatment. Despite a slight improvement at T2, the BEP group had still higher percentages of sperm aneuploidies than other groups. No impairment of sperm aneuploidies and DNA status were observed in the Carb group both after one and two years from the end of treatment

  6. Evaluation of outer dense fiber-1 and -2 protein expression in asthenozoospermic infertile men

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    Silvia W. Lestari

    2015-07-01

    Full Text Available Background: Most of male infertility are caused by defect in sperm motility (asthenozoospermia. The molecular mechanism of low sperm motility in asthenozoospermic patients has not been fully understood. Sperm motility is strongly related to the axoneme structure which is composed of microtubules and supported by outer dense fiber (ODF and fibrous sheath (FS protein. The objective of this study was to characterize the ODF (ODF1 and ODF2 expression in asthenozoospermic infertile male and control normozoospermic fertile male.Methods: Asthenozoospermic samples (n=18 were collected from infertile patients at Andrology Lab, Cipto Mangunkusumo Hospital Jakarta and control were taken from normozoospermic fertile donor (n=18. After motility analyses by computer-assisted sperm analysis (CASA, semen were divided into two parts, for Western blot and for immunocytochemistry analysis. Antibody against ODF1 and ODF2 protein were used in both analyses.Results: Analysis of ODF1 protein expression showed bands with molecular weight of ~30 kDa and ODF2 ~85 kDa. The mean band intensity of ODF1 and ODF2 protein were lower in the asthenozoospermic group (AG compared to normozoospermic group (NG. Moreover, both ODF proteins were less intense and less localized in the AG than NG. Sperm motility was lower in AG, compared to control NG, i.e. average path velocity (VAP = 32.07 ± 7.03 vs 37.58 ± 8.73 µm/s, p = 0.455; straight line velocity (VSL = 24.17 ± 6.90 vs 27.61 ± 4.50 µm/s, p = 0.317 and curvilinear velocity (VCL = 45.68 ± 7.91 vs 55.55 ± 16.40 µm/s, p = 0.099.Conclusion: There is down-regulation of ODF1 and ODF2 protein expression and less-compact localization in AG sperm compared to the NG. These changes might have caused disturbances in the sperm motility as observed in this study.

  7. 高血压与勃起功能障碍相互关系研究进展%Correlation between hypertension and erectile dysfunction

    Institute of Scientific and Technical Information of China (English)

    刘继红; 凌青

    2011-01-01

    勃起功能障碍(ED)与高血压之间的关系是男科学研究的重点领域.目前研究认为,这两种疾病拥有相似的病理生理过程,如氧化应激效应造成血管内皮损害以及RhoA/Rho激酶活性上调.两种疾病均为血管功能损害这一病理过程的不同阶段.定期细致而全面评估高血压合并ED患者病情,并予以合理药物治疗显得尤为重要.在高血压患者中,5型磷酸二酯酶抑制剂无论是单用还是联合抗高血压药物使用都取得了令人满意的效果.目前,基因治疗以及脂肪源性干细胞治疗都展现出了良好的前景,通过转化医学方法可使其更好的为临床服务.%The relationship between erectile dysfunction (ED) and hypertension is a focus in andrological research. ED and hypertension share some pathophysiologic pathways, such as oxidative stress-induced endothelial dysfunction and up-regulated RhoA/Rho kinase activity, and both are the diseases at different stages of the pathological process of vascular dysfunction. Thus, it is particularly important to conduct regular and meticulous evaluation of such patients, so as to give rational individualized medication. Phosphodiesterase-5 inhibitors have an excellent efficacy and safety profile in the management of hypertension, either used alone or with antihypertensive medication. At present, gene therapy and adipose-derived stem cell therapy have displayed favorable prospects in the management of ED and hypertension, and translational medicine may help bring more clinical benefits.

  8. Profile of vintafolide (EC145 and its use in the treatment of platinum-resistant ovarian cancer

    Directory of Open Access Journals (Sweden)

    Luyckx M

    2014-03-01

    Full Text Available Mathieu Luyckx,1,2 Raffaella Votino,1 Jean-Luc Squifflet,1,2 Jean-François Baurain2,31Gynecology and Andrology Unit, 2Centre du cancer, Gynecologic Oncology Group, 3Medical Oncology Unit, Cliniques Universitaires Saint-Luc, Brussels, BelgiumObjective: Our aim was to review the profile of vintafolide (EC145 and its rationale for use in platinum-resistant ovarian cancer. First we investigated the folate receptors (FRs, folate's pathway into cells, and its expression in normal and cancerous cells, before detailing the mechanism of action of vintafolide, its clinical applications, and the results of different study phases.Materials and methods: A literature search was conducted through Pubmed/Medline, Google, ClinicalTrials.gov and websites of pharmaceutical companies. Only articles in English were selected. All articles investigating folate receptor expression in ovarian cancer were selected first, than articles reviewing platinum resistance. Papers about vintafolide were collected, while those talking about synthesis and biochemistry concerns were excluded. The different Phase I and II studies were read, and an update on the website of pharmaceuticals companies were added.Results: FR is a bundle-membrane receptor that is expressed normally in some normal tissues on the apical surface of cells, but highly expressed in ovarian cancer cells (>80%. It collects folate through endocytosis. Chemotherapy does not modify its expression in ovarian cancer cells, and its expression appears to be mostly associated with a poor prognosis and platinum resistance. Vintafolide is a folate-desacetylvinblastine monohydrazide conjugate, allowing a liberation of the drug into the cytoplasm of cancerous cells via the FR-α (FR α and endocytosis, with high specificity. Phase I studies showed a 2.5 mg bolus dose to be nontoxic, with moderately adverse events. Phase II clinical trials for the first time demonstrated a statistically significant improvement in disease

  9. Influence of erectile dysfunction course on its progress and efficacy of treatment with phosphodiesterase type 5 inhibitors

    Institute of Scientific and Technical Information of China (English)

    LIU De-feng; JIANG Hui; HONG Kai; ZHAO Lian-ming; TANG Wen-hao; MA Lu-lin

    2010-01-01

    Background Erectile dysfunction (ED) is a common impairment among older men, and the prevalence rates increase sharply after age of 60 years. Most studies have focused on the prevalence rate or dangerouse factors. The aim of this study was to investigate the basic epidemiologic data about ED patients with different ED courses. The purpose of this researth was to understand the therapeutic effect of phosphodiesterase type 5 inhibitor (PDE5-1) and see how and why the ED course impact the progress of ED and the therapeutic effect of PDE5-1 treatment.Methods From June 2008 to June 2009, 4252 questionnaires (Quality of Erection Questionnaire, QEQ) were gathered from 46 centers by urology or andrology doctors all around China. Patients with ED (age > 20 years) filled in first half of the questionnaires when they came for the first time, and then completed the second half 4 weeks after PDE5-1 therapy.Results ED courses of most patients were less than 5 years (<5 years, 74.0%; 5-10 years 20.8%; >10 years, 5.2%). As ED course increasing, the incidence of the risk factors of ED, such as smoking, drinking, hypertension, diabetes, heart disease and hyperlipidemia also increase (P ≤0.01). PDE5-1 was effective in improving the quality of sexual activities (P ≤0.01). Administration of PDE5-1 improves satisfaction, enjoyment and frequency of sexual activities. The longer the ED course, the worse the therapeutic effect (<5 years, 96.1%; 5-10 years, 94.9%; >10 years, 89.0%) (P<0.01).Conclusions The ED course greatly affected the therapeutic effect of PDE5-1, the patients with ED should consult doctor at early stage of the disease. Admistration of PDE5-1 effectively improves the penile erection and the quality of sexual life of the patients hence should be considered as first-line medicine in the treatment of ED.

  10. The chance for fertility in adolescent boys after corrective surgery for varicocele.

    Science.gov (United States)

    Hadziselimovic, F; Herzog, B; Jenny, P

    1995-08-01

    We estimated the efficacy of a surgical procedure in adolescent patients with varicocele and left testicular atrophy. A total of 25 young men (mean age 23.6 years) had a complete andrological followup for 10 years after successful ligation of the spermatic vein (according to Ivanissevich) to correct left varicocele and testicular atrophy. Levels of follicle-stimulating hormone, luteinizing hormone and testosterone in the plasma were normal in all cases. Patients were characterized into 2 distinct groups: group A--11 patients with asthenoteratospermia and group B--14 with a normal spermiogram. There was a significant difference between groups A and B in the number of sperm per ejaculate (32 x 10(6) in A and 234.9 x 10(6) in B, p < 0.001). Preoperatively there was no difference between these 2 groups regarding testicular atrophy of the left compared to the right testis (87% in A and 86.4% in B) and the comparative testicular histology of biopsies since the number of Ad spermatogonia per tubule was considerably reduced in all patients (right side 0.68 +/- 0.71 and left side 0.38 +/- 0.39 in A, and right side 0.15 +/- 0.17 and left side 0.14 +/- 0.11 in B). In both groups there was no distinguishable difference in the degree of atrophy of seminiferous tubules or Leydig cells in both testes, or patient age at surgery (mean 13.3 years in A and 12.8 years in B). While the left testis of patients in group B caught up in size to the contralateral testis, the left testicular volume in patients in group A was only 80% of the right testicular volume (p < 0.03, the Fisher test). One patient from group B required a second surgical procedure because of a relapse. Persistent atrophy of the left testis in group A indicates that some patients benefit suboptimally from the conventional surgical procedure. PMID:7609165

  11. Prevalent false positives of azoospermia factor a (AZFa) microdeletions caused by single-nucleotide polymorphism rs72609647 in the sY84 screening of male infertility

    Institute of Scientific and Technical Information of China (English)

    Qing Wu; Hui-Juan Shi; Guo-Wu Chen; Tao-Fei Yan; Hui Wang; Yu-Ling Liu; Zheng Li; Shi-Wei Duan; Fei Sun; Yun Feng

    2011-01-01

    Multiplex polymerase chain reaction (PCR) has been widely used to detect Y-chromosome microdeletions,which is one of the major causes of male infertility.Both the European Academy of Andrology (EAA) and the European Molecular Genetics Quality Network (EMQN) have recommended the use of sY84 and sY86 markers for the detection of azoospermia factor a (AZFa) microdeletion during DNA testing for male infertility.In this study,a large-scale analysis of AZF microdeletion in a total of 630 Chinese males,including healthy semen donors (n=200),infertile males with normal sperm count (n=226) and patients with either nonobstructive azoospermia or severe oligozoospermia (n=204),was performed.A series of nine sequence-tagged site (STS) markers from the AZF region of the Y chromosome was used to detect microdeletions.All primers were designed based on the recommendations of the National Center for Biotechnology Information.An unusually high incidence (73/630,11.6%) of sY84-absent but sY86-present genotypes was observed in the AZFa microdeletion screening.Sequencing the sY84-flanking region revealed a total of 73 patients with sY84-absent but sY86-present genotypes have a T-to-G transversion at the fifth base from the 5' end of the reverse sY84 primer.These prevalent false positives,which were not only observed in infertile men,but also observed in donors,resulted from a single-nucleotide polymorphism (SNP) named rs72609647 in the targeting sequence of the reverse sY84 primer.Our study suggests that a pre-screening of existence of rs72609647 polymorphism can prevent the frequent false positive results of AZFa microdeletions detection in the infertile Chinese males.Given the SNP rs72609647 was recently found in a deep sequencing of a Chinese individual,the current EAA and EMQN standards may need to be scrutinized among different populations to avoid the potential genetic variations in the primer binding sequences.

  12. Perspective on plasma membrane cholesterol efflux and spermatozoal function

    Directory of Open Access Journals (Sweden)

    Dhastagir Sultan Sheriff

    2010-01-01

    Full Text Available The process of sperm maturation, capacitation, and fertilization occur in different molecular milieu provided by epididymis and female reproductive tract including oviduct. The different tissue environment with different oxygen tension and temperature may still influence the process of sperm maturation and capacitation. Reactive oxygen species (ROS is reported to be an initial switch that may activate the molecular process of capacitation. Therefore, the generation of reactive oxygen species and its possible physiological role depends upon a balance between its formation and degradation in an open environment provided by female reproductive tract. The sensitivity of the spermatozoa to the action of ROS may be due to its exposure for the first time to an oxygen rich external milieu compared to its internal milieu in the male reproductive tract. Reduced temperature in testicular environment coupled with reduced oxygen tension may be the right molecular environment for the process of spermatogenesis and spermiogenesis. The morphologically mature spermatozoa then may attain its motility in an environment provided by the caput epididymis wherein, the dyenin motor can become active. This ability to move forward will make the spermatozoa physiologically fit to undertake its sojourn in the competitive race of fertilization in a new oxygen rich female reproductive tract. The first encounter may be oxygen trigger or preconditioning of the spermatozoa with reactive oxygen species that may alter the spermatozoal function. Infertility is still one of the major global health problems that need medical attention. Apart from the development of artificial methods of reproduction and development of newer techniques in the field of andrology focuses attention on spermatozoal structure and metabolism. Therefore, understanding the molecular mechanisms involved in fertilization in general and that of sperm capacitation in particular may help lead to new and better

  13. Anteroposterior diameter of the infrarenal abdominal aorta is higher in women with polycystic ovary syndrome

    Directory of Open Access Journals (Sweden)

    Marco Matteo Ciccone

    2009-06-01

    Full Text Available Marco Matteo Ciccone1, Stefano Favale1, Anish Bhuva4, Pietro Scicchitano1, Vito Caragnano1, Cristina Lavopa2, Giovanni De Pergola3, Giuseppe Loverro21Department of Cardiology; 2Department of Gynecology and Obstetrics; 3Section of Internal Medicine, Endocrinology, Andrology, and Metabolic Diseases, University of Bari, DETO, Italy; 4University College of London, London, UKBackground: Women affected by polycystic ovary syndrome (PCOS are known to be at higher risk of cardiovascular disease. The aim of this study was to identify the artery that first is affected by early pre-atherosclerotic changes in PCOS. Methods: Twenty-nine women with PCOS aged 17 to 27 years and 26 healthy nonhyperandrogenic volunteers with regular menses (control women aged 16 to 28 years were enrolled. All PCOS patients were overweight or obese (body mass index [BMI] ≥ 25. Diagnosis of PCOS was performed in line with the 2003 Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Accordingly, PCOS was defined when at least two of the following three features were present after exclusion of other etiologies: 1 oligomenorrhea and or anovulation; 2 hyperandrogenism and/or hyperandrogenemia; and 3 polycystic ovaries visible at ultrasound. Androgen excess or related disorders were excluded. The intima-media thickness (IMT of common carotid arteries and common femoral arteries and the anteroposterior diameter of the infrarenal abdominal aorta were measured by ultrasound. Lutenizing hormone (LH, follicle-stimulating hormone (FSH, estradiol, total testosterone, androstenedione, and sex hormone-binding globulin (SHBG serum levels were measured between the 3rd and the 6th day of spontaneous or progestin-induced menstrual cycle. Our study was performed in the absence of any medical treatment. Results: Women with PCOS showed a higher LH to FSH ratio (p < 0.01, increased fasting insulin (p < 0.001, total testosterone (p < 0.001, and androstenedione (p < 0.001 levels, and lower

  14. Surgical or conservative treatment of penile fracture

    Directory of Open Access Journals (Sweden)

    Đorđević D.

    2008-01-01

    Full Text Available Introduction: Penile fracture presents with rupture of corpora cavernosa. It is not rare but is remarkable. Treatment options are controversial. Aim: To establish the incidence, what are early and late complications in patients treated surgically or with conservative treatment options (prospective/retrospective and randomized analysis. To find out what therapy verified as superior. Material and method: The total of 32 patients with typical acute penile fracture were analyzed. The patients were between 20 and 56 years of age (Mean age 40+7.25 SD. A total of 11 patients that presented up to 48h after the rupture of tunica albuginea (34.37% were operated, while 9 patients (28.13% were conservatively treated. 12 patients (37.5% reported to andrology consulting room due to penile fibrous alterations and/or erectile dysfunction 6 to 14 months after the anamnesticaly established, typical penile fracture ("primary latent penile fracture". Both groups of patients were strictly clinically followed 3, 6, 9 and 12 months after the penile fracture. Eventual development of late complications (erectile dysfunction ED, penile curvature, induratio, caverno-urethral fistula and urethral stenosis was also recorded. Etiology of ED was investigated: anamnesticaly, by hormone and laboratory analysis, using penodynamic test (PGE1, Duplex Doppler echosonography, and dynamic cavernosography. Results: In the operated group of patients, (11 pts, 34.37% preserved erectile capacity was recorded and no penile deformity or plaque lesions on the site of suture, after the patients were recommended to have 4 weeks of sexual abstinence. The rupture of tunica albuginea was always transversal in relation to penile axis i.e. in relation to axial force against which the penis acts during the intercourse. The rupture is always on the basis or mid penile portion . Out of 21 (65.63% conservatively treated patients in 13 (61.9% plaque lesions (longitudinal diameter 2 cm was recorded

  15. Características seminais de touros Curraleiros e Holandeses submetidos à insulação escrotal Seminal characteristics of Curraleiro and Holstein bulls submitted to scrotal insulation

    Directory of Open Access Journals (Sweden)

    Tomaz Gelson Pezzini

    2006-05-01

    Full Text Available O objetivo deste trabalho foi comparar uma raça naturalizada brasileira com uma raça européia quanto à adaptação às altas temperaturas. Foram avaliados os efeitos da insulação escrotal, por 48 horas, nas características seminais de touros Curraleiros (n = 5 e Holandeses (n = 6. Uma seqüência de coletas de sêmen e avaliação andrológica dos touros foi realizada antes (duas coletas e depois (nove coletas semanais da insulação escrotal. A motilidade espermática progressiva teve queda significativamente menor na raça Curraleira (25% do que na Holandesa (50%, no período pós-insulação, e retornou aos valores pré-insulação mais precocemente nos touros Curraleiros, aos 37 dias após a insulação escrotal. O vigor espermático nos Curraleiros (15,2% teve queda menor do que nos Holandeses (47,8%. O número de espermatozóides por ejaculado caiu de forma similar nos dois grupos depois da insulação, respectivamente 67,9 e 79,4%, para Curraleiros e Holandeses, entre 16 e 23 dias após a insulação. A porcentagem de espermatozóides anormais atingiu valores máximos entre 16 e 30 dias após a insulação e foi maior aos 30 dias nos touros Holandeses (41,3±5,9%. Os touros Curraleiros são mais tolerantes aos efeitos da insulação escrotal nas características seminais do que os Holandeses.The objective of this work was to compare the adaptation to high temperatures of a Brazilian local breed with an European one. The effects of scrotal insulation for 48 hours on seminal characteristics of Curraleiro (n = 5 versus Holstein (n = 6 bulls were evaluated. A sequence of semen collection and andrologic evaluation was performed before (two collections and after (nine weekly collections scrotal insulation. Among the seminal parameters evaluated, the progressive sperm motility had a significantly lower decrease in Curraleiro (25% than in Holstein bulls (50%, during the postinsulation period. Sperm motility of Curraleiro bulls, 37 days

  16. Testosterone replacement alters the cell size in visceral fat but not in subcutaneous fat in hypogonadal aged male rats as a late-onset hypogonadism animal model

    Directory of Open Access Journals (Sweden)

    Abdelhamed A

    2015-03-01

    Full Text Available Amr Abdelhamed,1,2 Shin-ichi Hisasue,1 Masato Shirai,3 Kazuhito Matsushita,1 Yoshiaki Wakumoto,1 Akira Tsujimura,1 Taiji Tsukamoto,4 Shigeo Horie1 1Department of Urology, Juntendo University, Graduate School of Medicine, Tokyo, Japan; 2Department of Dermatology, Venereology and Andrology, Sohag University, Graduate School of Medicine, Sohag, Egypt; 3Department of Urology, Juntendo University Urayasu Hospital, Urayasu, Japan; 4Department of Urology, School of Medicine, Sapporo Medical University, Sapporo, Japan Background: Patients with late-onset hypogonadism (LOH benefit from testosterone replacement by improvement in the parameters of the metabolic syndrome, but fat cell morphology in these patients is still unclear. This study aims to determine the effect of testosterone replacement on the morphology of fat cells in subcutaneous and visceral adipose tissue and on erectile function in hypogonadal aged male rats as a model of LOH. Methods: Ten male Sprague-Dawley rats aged 20–22 months were randomly allocated to two groups, ie, aged male controls (control group, n=5 and aged males treated with testosterone replacement therapy (TRT group, n=5. Testosterone enanthate 25 mg was injected subcutaneously every 2 weeks for 6 weeks. At 6 weeks, the intracavernous pressure (ICP and mean arterial blood pressure (MAP ratio was assessed. Visceral and subcutaneous adipose tissue specimens were collected and analyzed using Image-J software. Results: Body weight at 2, 4, and 6 weeks after TRT was 800.0±35.4 g, 767.5±46.3 g, and 780±40.4 g, respectively (not statistically significant. The ICP/MAP ratio was 0.341±0.015 in the TRT group and 0.274±0.049 in the control group (not statistically significant. The median subcutaneous fat cell size was 4.85×103 (range 0.85–12.53×103 µm2 in the control group and 4.93×103 (range 6.42–19.7×103 µm2 in the TRT group (not statistically significant. In contrast, median visceral fat cell size was significantly

  17. 不育症患者精子DNA碎片化指数与精子常规参数关系的研究%Research on the relationship between sperm DNA fragmentation and semen parameters of infertile men

    Institute of Scientific and Technical Information of China (English)

    孙超; 徐志鹏; 石亮; 戴玉田

    2011-01-01

    目的:近年研究认为精子DNA碎片化是评价精子质量的重要指标,本研究主要运用吖啶橙实验(acridine orange test,AOT)检测不育症患者精子DNA碎片化指数(DNA fragmentation index,DFI)与精子常规参数之间的关系.方法:收集本院男科门诊376例不育症患者的精液标本,采用改良的Neubauer血细胞计数板人工分析精子密度,计算机辅助精液分析(CASA)分析精子活力.精子形态分析采用Shorr染色法,分析标准采用WHO推荐的Tygerberg严格标准.采用AOT检测精子DNA碎片化程度.结果:DFI与精子密度呈负相关(r=-0.150,P=0.003)、与精子总活动率呈负相关(r=-0.114,P=0.028)、与精子前向运动率无统计学相关性(r=-0.089,P=0.085)、与精子正常形态率呈负相关(r=-0.155,P=0.003).结论:精子DNA碎片化指数与精子的密度、总活动率及精子正常形态率具有负相关性,AOT检测的DFI值为男性不育症的诊疗提供了一个新的指标.%Objective:Sperm DNA fragmentation has been assessed as a positive predictor of fertility potential in recent years.The aim of this study is using the acridine orange test (AOT) to analyze the relationship between sperm DNA fragmentation indexes(DFI)and semen conventional parameters of infertility men.Methods:Semen samples were collected from 376 infertility male patients in our andrology outpatient department.The samples were analyzed by improved Neubauer haemocytometer chamber and computer-aided sperm analysis(CASA) system to obtain concentration and motility parameters.All the samples were stained by Short staining method and the smears were analyzed according to Tygerberg strict criteria recommended by World Health Organization (WHO) to obtain morphology parameters.The DFI as marker of sperm DNA damage determined using the AOT.Results:Significant negative correlations were noted between DFI and sperm concentmtion(r=-0.150,P=0.003),motility(r=-0.114,P=0.028)and morphology(r=-0.155,P=0.003).No

  18. Application of multiplex PCR in detection of Y chromosomal microdeletions%多重PCR在Y染色体微缺失检测中的应用

    Institute of Scientific and Technical Information of China (English)

    杨欢利; 毛英姿; 诸溢扬; 陈辉波; 陆文浩; 李真法

    2012-01-01

    Objective: To set up multiplex PCR systems for detection of Y chromosomal microdeletions. Methods: Six specific sequence tagged sites were selected according to the laboratory guideline supported by European Academy of Andrology( EAA) and European Molecular Genetics Quality Net Work(EMQN) and nine specific sequence tagged sites were added up on this base. The primers were designed according to 15 STS of Y chromosome. The multiplex PCR systems were set up using the gene of sex determining region Y(SRY) as the internal control. The detection of Y chromosomal microdeletions was carried out on azoospermia group, oligzoospermia group, normal group and other group (at least one of results of semen was below the reference values). Results: Y chromosomal microdeletions were found 5.9% in azoospermia group and 17. 2% in oligzoospermic group by using the multiplex PCR systems construced with 15 STS. No microdeletions were seen in normal group and other group. The specificity of multiplex PCR was found to be 100% and no false positive or false negative was found. Conclusion: Multiplex PCR is suitable for screening Y chromosomal microdeletions and the operation is simple, shortcut and has reliable results, good reproducibility and important appliciation value in assisted reproductive examination.%目的:建立检测Y染色体微缺失的多重PCR体系.方法:参照欧洲男科协会和欧洲分子遗传实验室质控网推荐的6个特异性序列标签(STS),并在此基础上增加9个STS,依据Y染色体上15个STS设计引物,以性别决定基因(SRY)为内参建立多重PCR体系;对无精症组、严重少精症组、精液正常组及其它组(精液参数至少一项低于参考值)进行Y染色体微缺失检测.结果:建立的15个STS多重PCR体系检测到无精子症组缺失率为5.9%,严重少精子症组缺失率为17.2%,精液正常组及其它组中未发现缺失.多重PCR检测的特异性为100%,未发现假阳性或假阴性结果.结论:多

  19. Investigation of the potential of optical coherence tomography (OCT) as a non-invasive diagnostic tool in reproductive medicine

    Science.gov (United States)

    Trottmann, Matthias; Homann, Christian; Leeb, R.; Doering, D.; Kuznetsova, J.; Reese, S.; Stief, C. G.; Koelle, S.; Sroka, R.

    2015-02-01

    Introduction and objective: In Europe, nearly every sixth couple in the reproductive age is involuntarily childless. In about 30%, both male and female reveal fertility problems. In about 10% of infertile men, azoospermia is the underlying cause. As conventional therapeutic options are limited, surgical testicular sperm extraction (TESE) is necessary to obtain sperms for assisted reproductive techniques. Regarding the females, up to 30% of all idiopathic infertilities are due to alterations of the uterine tube So far, no imaging technique, which does not require any labelling, is available to evaluate the male and female genital tract at a microscopic level under in vivo conditions. Thus, the aim of this study was to investigate the potential of optical coherence tomography (OCT) as a non-invasive diagnostic tool in gynaecology and andrology. Material and Methods: Tissues samples from the bovine testis, epididymis, vas deferens, ovary, oviduct (ampulla and isthmus) and uterus were obtained immediately after slaughter (14 cows aged 3 to 8 years and 14 bulls aged 3 to 6 years; breeds: Holstein- Friesian, and Deutsches Fleckvieh). Imaging was done by using the US Food and Drug Administration (FDA) approved probe-based Niris Imaging System (Imalux, Cleveland, Ohio, USA) and the Telesto 1325 nm OCT System and Ganymede 930 nm OCT System (Thorlabs Inc., Dachau, Germany). All images obtained were compared to histological images after paraffin embedding and HE staining. Results: OCT imaging visualized the microarchitecture of the testis, epididymis, spermatic duct and the ovary, oviduct and uterus. Using the Thorlabs systems a axial resolution of approx. 5μm and lateral resolution of 8- 15μm could be achieved. Different optical tissue volumes could be visualized, which depends on the optical penetration depth of the wavelength of the system used. While the tissue volume observed by probe based Imalux-OCT is similar to the used Thorlabs systems, the optical resolution is

  20. Efficacy Analysis of Gujing Tang Combined with Paroxetine of Treatment of Premature Ejaculation for 60 Cases%固精汤结合帕罗西汀治疗早泄60例疗效分析

    Institute of Scientific and Technical Information of China (English)

    孙洁; 李秋芬; 江少波

    2013-01-01

    [Objective] A randomized control ed trial of traditional Chinese medicine recipe Gujing Tang treatment of premature ejaculation was studied. [Methods] The subjects: 60 patients with premature ejaculation form department of andrologic outpatient, the patients were randomly divided into two groups, Integrated TCM-WM Groups and paroxetine Groups. 30 cases in each group. The Integrated TCM-WM Groups were given Gujing Tang , with paroxetine 10mg, oral, Qd at the same time; The paroxetine groups were given paroxetine 10mg, oral, Qd. Both groups were treated for 3 months. Ejaculation status was evaluated at the timepoint:before treatment, 3 months after treatment,and fol ow-up evaluation of six months after treatment. Evalu-ate parameter including Intravaginal ejaculation latency(IELT) and score of sexual function and Chinese patients with premature ejaculation evaluation -5 (CIPE-5). [Results] After 3 months, both groups were significantly improved, and Integrated TCM-WM Groups improved more significantly. After 6 months of fol ow-up, IELT, motion times and CIPE-5 score of Integrated TCM-WM Groups decreased slightly, but stil had significant difference com-pared to before treatment, and this parameter of Paroxetine groups was returned to the level of baseline, and had no significant difference compared with baseline. [Conclusion] Traditional Chinese medicine Recipe Gujing Tang combined with paroxetine, could not only have rapid onset, enhance patient confidence, improve the psychological state, but also improve the long-term efficacy and avoid recurrent disease after treatment, therefore can achieve ef-fective treatment of premature ejaculation.%[目的]研究固精汤结合帕罗西汀对早泄(premature ejaculation, PE)的治疗效果。[方法]将2007年1月至2010年6月浙江省中医药大学附属第一医院泌尿外科就诊的早泄患者60例随机分为固精汤组和帕罗西汀组,每组30例。帕罗西汀组予以帕罗西汀10mg,口服,1

  1. Observation of the effect of otanical drug aescuven forte tablets in mild varicocele with asthenospermia%迈之灵片治疗轻度精索静脉曲张伴弱精子症效果观察

    Institute of Scientific and Technical Information of China (English)

    孟庆杰; 张炜; 尹吉明; 郭通航

    2014-01-01

    Objective To evaluate the clinical effect of botanical drug aescuven forte tablets in mild varicocele with asthenospermia.Methods From February 2010 to June 2012 in andrology clinic,98 patients diagnosed of mild varicocele with asthenospermia were given botanical aescuven forte tablets.Before treatment and 12 weeks after treatment,computer-aided sperm analysis system automatically (CASA) was observed.Results A total of 95 patients completed the treatment,3 cases of interrupt or abandon treatment were not included.84 cases were improved with semen quality and the effective rate was 88.4% (84/95).Among them,the sperm concentration and semen volume before and after treatment was no significantly different (P > 0.05).Sperm total motility (PR ± NP),forward motility rate (PR),fast forward motion of sperm rate (VSL > 35 μm/s),the average velocity (VAP),straight-line velocity (VSL),curvilinear velocity (VCL) and other major indicators of sperm motion parameters were all significantly improved after treatment [(40 ± 14)% vs (28 ± 12)%,(30 ± 11)% vs (18 ± 9)%,(18 ±9)% vs (10 ±6)%,(26 ±6) μm/s vs (21 ±4) μm/s,(24 ± 6) μm/s vs (21 ± 5) μm/s,(32 ± 6) μm/s vs (26 ± 6) μm/s] (P < 0.01).During treatment and 3 months after treatment,the pregnancy rate was 12.6% (12/95).Conclusion The botanical drug aescuven forte tablets has a good therapeutic effect on mild varicocele.%目的 评价迈之灵治疗轻度精索静脉曲张伴弱精子症的临床效果.方法 选取2010年2月至2012年6月在安徽省宿州市立医院男性科门诊就诊的98例诊断为轻度VC伴弱精子症的患者,给予植物药制剂迈之灵片口服,150 mg/次,2次/d,6周为1个疗程,共治疗2个疗程,分别于治疗前和治疗后12周,采用计算机辅助精子自动分析系统进行精液参数分析,以评价治疗效果.结果 入选患者98例.共95例患者完成全部治疗疗程,中断或放弃治疗者3例,未纳入统计.除11例患者精液质