2009-2012 State-ANDRA four-year contract

International Nuclear Information System (INIS)

2009-01-01

Signed by State representatives and representatives of the French national Agency for radioactive waste management (ANDRA), this document defines for the four years to come several objectives for the action and the activities of the ANDRA considered as an industrial operator, as an innovating actor possessing a high level research capacity, as a public expert guaranteeing the radioactive waste management solutions, as an information and valorization centre for France and foreign countries. All these objectives are further detailed in appendix

Mati Hint - sünge keeleteadlane ja pessimistlik ühiskonnategelane / Mari Klein

Index Scriptorium Estoniae

Klein, Mari, 1979-

2007-01-01

11. septembril peeti Tallinna Ülikoolis seminari, mis oli pühendatud Mati Hindi 70. sünnipäevale. Ettekannetega esinesid ülikoolikaaslased, sõbrad ja kolleegid Rein Veidemann, Haldur Õim, Martin Ehala, Mats Traat, Tapani Lehtinen, Jaan Kaplinski

lin-4 and the NRDE pathway are required to activate a transgenic lin-4 reporter but not the endogenous lin-4 locus in C. elegans.

Science.gov (United States)

Jiao, Alan L; Foster, Daniel J; Dixon, Julia; Slack, Frank J

2018-01-01

As the founding member of the microRNA (miRNA) gene family, insights into lin-4 regulation and function have laid a conceptual foundation for countless miRNA-related studies that followed. We previously showed that a transcriptional lin-4 reporter in C. elegans was positively regulated by a lin-4-complementary element (LCE), and by lin-4 itself. In this study, we sought to (1) identify additional factors required for lin-4 reporter expression, and (2) validate the endogenous relevance of a potential positive autoregulatory mechanism of lin-4 expression. We report that all four core nuclear RNAi factors (nrde-1, nrde-2, nrde-3 and nrde-4), positively regulate lin-4 reporter expression. In contrast, endogenous lin-4 levels were largely unaffected in nrde-2;nrde-3 mutants. Further, an endogenous LCE deletion generated by CRISPR-Cas9 revealed that the LCE was also not necessary for the activity of the endogenous lin-4 promoter. Finally, mutations in mature lin-4 did not reduce primary lin-4 transcript levels. Taken together, these data indicate that under growth conditions that reveal effects at the transgenic locus, a direct, positive autoregulatory mechanism of lin-4 expression does not occur in the context of the endogenous lin-4 locus.

lin-4 and the NRDE pathway are required to activate a transgenic lin-4 reporter but not the endogenous lin-4 locus in C. elegans.

Directory of Open Access Journals (Sweden)

Alan L Jiao

Full Text Available As the founding member of the microRNA (miRNA gene family, insights into lin-4 regulation and function have laid a conceptual foundation for countless miRNA-related studies that followed. We previously showed that a transcriptional lin-4 reporter in C. elegans was positively regulated by a lin-4-complementary element (LCE, and by lin-4 itself. In this study, we sought to (1 identify additional factors required for lin-4 reporter expression, and (2 validate the endogenous relevance of a potential positive autoregulatory mechanism of lin-4 expression. We report that all four core nuclear RNAi factors (nrde-1, nrde-2, nrde-3 and nrde-4, positively regulate lin-4 reporter expression. In contrast, endogenous lin-4 levels were largely unaffected in nrde-2;nrde-3 mutants. Further, an endogenous LCE deletion generated by CRISPR-Cas9 revealed that the LCE was also not necessary for the activity of the endogenous lin-4 promoter. Finally, mutations in mature lin-4 did not reduce primary lin-4 transcript levels. Taken together, these data indicate that under growth conditions that reveal effects at the transgenic locus, a direct, positive autoregulatory mechanism of lin-4 expression does not occur in the context of the endogenous lin-4 locus.

ANDRA 2009 activity report: managing today to prepare the future

International Nuclear Information System (INIS)

2010-01-01

This activity report first presents the four-year contract between the French State and the ANDRA (the French national agency for the management of radioactive wastes), the personnel working for ANDRA. Then, it presents various activities of ANDRA in the field of the management of radioactive materials and pollutions (material and waste survey, security of polluted sites, collecting radioactive wastes and objects, public information), its operational activities (evolution and project of storage sites), its design activities for storage sites for different types of wastes (life and activity). It also describes activities in the fields of international expertise and of protection of industrial concepts

Gromootvod polititsheskogo naprjazhenija / Andra Veidemann ; interv. Virkko Lepassalu

Index Scriptorium Estoniae

Veidemann, Andra, 1955-

2007-01-01

Eesti kultuuriatashee Moskvas vastab küsimustele, mis puudutavad tööd diplomaadina, karjääri, Eesti-Vene kultuurisuhteid pärast aprillisündmusi, Eesti kultuuri tutvustamist, eesti kirjanike teoste tõlkimist ja avaldamist Venemaal. Vt. samas: Spravka "DD"

In vitro expansion of Lin+ and Lin- mononuclear cells from human peripheral blood

Science.gov (United States)

Norhaiza, H. Siti; Rohaya, M. A. W.; Zarina, Z. A. Intan; Hisham, Z. A. Shahrul

2013-11-01

Haematopoietic stem cells (HSCs) are used in the therapy of blood disorders due to the ability of these cells to reconstitute haematopoietic lineage cells when transplanted into myeloablative recipients. However, substantial number of cells is required in order for the reconstitution to take place. Since HSCs present in low frequency, larger number of donor is required to accommodate the demand of transplantable HSCs. Therefore, in vitro expansion of HSCs will have profound impact on clinical purposes. The aim of this study was to expand lineage negative (Lin-) stem cells from human peripheral blood. Total peripheral blood mononuclear cells (PBMNCs) were fractionated from human blood by density gradient centrifugation. Subsequently, PBMNCs were subjected to magnetic assisted cell sorter (MACS) which depletes lineage positive (Lin+) mononuclear cells expressing lineage positive markers such as CD2, CD3, CD11b, CD14, CD15, CD16, CD19, CD56, CD123, and CD235a to obtained Lin- cell population. The ability of Lin+ and Lin- to survive in vitro was explored by culturing both cell populations in complete medium consisting of Alpha-Minimal Essential Medium (AMEM) +10% (v/v) Newborn Calf Serum (NBCS)+ 2% (v/v) pen/strep. In another experiment, Lin+ and Lin- were cultured with complete medium supplemented with 10ng/mL of the following growth factors: stem cell factor (SCF), interleukin (IL)-3, granulocyte-macrophage colony stimulating factor (GM-CSF), 2IU/mL of Erythropoietin (Epo) and 20ng/mL of IL-6. Three samples were monitored in static culture for 22 days. The expansion potential was assessed by the number of total viable cells, counted by trypan blue exclusion assay. It was found that Lin+ mononuclear cells were not able to survive either in normal proliferation medium or proliferation medium supplemented with cytokines. Similarly, Lin- stem cells were not able to survive in proliferation medium however, addition of cytokines into the proliferation medium support Lin

Evaluation 2002 - perspectives 2003 of the Andra activities

International Nuclear Information System (INIS)

2003-01-01

The french Government entrusts the Andra, National Agency for the Radioactive Wastes Management, with three main missions presented in this paper. An industrial mission which concerns the implementation and the management of storage Centers. The research mission concerns researches in the domains of the earth sciences, the materials, the environment, the simulation, the monitoring and the survey. The Andra is also looking after the a mission of information with the realization of the National Inventory of wastes. (A.L.B.)

QING LIN

Indian Academy of Sciences (India)

QING LIN. Articles written in Journal of Genetics. Volume 96 Issue 4 September 2017 pp 535-544 RESEARCH ARTICLE. Effects of genetic variants of the bovine WNT8A gene on nine important growth traits in beef cattle · YONG-ZHEN HUANG YONG ZOU QING LIN HUA HE LI ZHENG ZI-JING ZHANG YONG-LONG DANG ...

ANDRA 2009 sustainable development report: managing today to prepare the future

International Nuclear Information System (INIS)

2010-01-01

After a discussion of the development of the taking into account of the sustainable development within the ANDRA (the French national agency for the management of radioactive wastes) and the activity of the ANDRA to limit its environmental footprint, this report presents the various activities of the ANDRA to anticipate these issues (by saving storage space, guaranteeing the storage reversibility of high activity and long life wastes, and keeping the memory of the storage centres), to protect the environment (by controlling waste packages, preserving the environment, and surveying health around storage centres), to cooperate with different institutions and bodies (population, local authorities, associations)

Andra. Everything on the management of radioactive wastes

International Nuclear Information System (INIS)

2014-08-01

This publication briefly presents the ANDRA, the French National Agency for the management of radioactive wastes, its mission, its activities, its financing, and some key figures. It briefly presents the phenomenon of radioactivity, radioactive wastes and their storage. It presents the different classes of radioactive wastes (very-low-level, low- and intermediate-level and short-lived, low-level and long-lived, high-level and intermediate-level and long-lived) and their storage principles. It sketches the pathway followed by a waste from its production to its storage. It presents the various ANDRA sites

Eerosest valgustatud / Rein Veidemann

Index Scriptorium Estoniae

Veidemann, Rein, 1946-

2002-01-01

Arvustus: Saarsen, Karin. Lõvi ja orhidee : [luuletused]. Tallinn : Eesti Raamat, 2002 ; Under, Marie. Under armastusest : [luuletused ja katkendid kirjadest] / valik ja järelsõna: Sirje Olesk. Tallinn : Tänapäev, 2002

Radioactive waste, from myth to reality: the stakes for Andra's educational communication efforts - 59287

International Nuclear Information System (INIS)

Comte, Annabelle

2012-01-01

Document available in abstract form only. Full text of publication follows: Andra is responsible for proposing and implementing industrial management solutions for France's radioactive waste. Andra's goal is to ensure that everyone has the opportunity to make up his or her own mind on a subject that generates such heated debate within our society. This duty of communication is enshrined in law and is an integral part of Andra's activities, in the same way as research, industry and risk management. Because the subject of radioactive waste is a complex one and concerns such a variety of audiences, Andra adapts its communication policy so that it is accessible to all, according to individual needs and levels of interest. For the 'non-specialists' (general public, young people, etc.) Andra proposes a system built around education and awareness-raising. Its aim is to make the subject of radioactive waste accessible to and comprehensible to as many as possible. Its educational communication approach is built on 3 pillars: first and foremost information, the keystone of any system of communication, then explanation and finally sharing with the legitimate stakeholders in this pedagogical approach. Providing dependable information Andra offers information that is appropriate to the level of knowledge of its audiences and uses all communication media

ANDRA takes responsibility for waste

International Nuclear Information System (INIS)

Wallard, Henri

1993-01-01

Concerned by the level of local public opposition to plans for disposing of high level radioactive waste, the French government and parliament launched comprehensive reviews of the issues involved. The resulting national programme, which is being carried out by ANDRA, is designed to ensure that all alternatives are examined and that the public and parliament have the last word. (Author)

Hearing of Mrs Marie-Pierre Comets and Mr Marc Sanson, commissioners of the Nuclear Safety Authority (ASN), as well as Mrs Marie-Claude Dupuis, general manager of the National Agency for the management of radioactive wastes (ANDRA), on the nuclear events in Cadarache

International Nuclear Information System (INIS)

2009-01-01

Representatives of the French Nuclear Safety Authority (ASN, Autorite de Surete Nucleaire) and of the French National Agency for the Management of Radioactive Wastes (ANDRA, Agence nationale pour la gestion des dechets radioactifs) answer questions about an incident which occurred in a workshop, where MOx fuel was produced and which is now being dismantled. It appeared that the amount of plutonium present in the gloveboxes has been largely under-assessed: 8 kg were expected, 22 kg of plutonium have already been recovered, and finally 39 kg might be recovered by the end the dismantling operations. Other issues are addressed like the ANDRA's projects of radioactive material geological storage, their technical and institutional aspects, and then again about the late declaration of the Cadarache incident

Candice Lin: paisaje, territorio y fronteras (Candice Lin: Landscape, Territory and Boundaries

Directory of Open Access Journals (Sweden)

Gabriel Baltodano Román

2017-11-01

Full Text Available Se analizan los contenidos ideológicos de la acuarela «Nacimiento de una nación» (2008, de Candice Lin. A partir de nociones como territorio, tropo caníbal, tipo botánico tropical y pensamiento fronterizo, se plantea una interpretación de esa paisajística pictórica, en que la artista-activista reflexiona sobre el régimen de representación visual. Mediante diversos procedimientos formales, Lin pone en entredicho preceptos centrales de la mentalidad colonialista, que contrapone a las concepciones indigenistas. Abstract An analysis is provided of the ideological contents of the watercolor “Birth of a Nation” (2008, by Candice Lin. This interpretation of this pictorial landscape is based on notions such as territory, cannibal tropes, tropical botanical types and border thinking. The artist activist reflects here on the regime of visual representation. Using different formal procedures, Lin questions central precepts of the colonialist mentality, in contrast with indigenous conceptions.

Andra - Everything you ever wanted to know about radioactive waste management

International Nuclear Information System (INIS)

2014-08-01

Andra is a publicly owned industrial and commercial body, set up by the French act of 30 December 1991. Its role was expanded by the 2006 Planning Act on the long-term management of radioactive materials and waste. Andra is independent of the producers of radioactive waste, and is under the supervision of the ministries responsible for energy, research and the environment. Andra is responsible for identifying, implementing and guaranteeing safe management solutions for all French radioactive waste, in order to protect present and future generations from the risks inherent in such substances. Andra's role involves a number of activities: running the two existing above-ground disposal facilities in the Aube, the first one for low- and intermediate- level, short-lived waste (LILW-SL) and the other one for very-low-level waste (VLLW), the Cires facility; monitoring the Manche disposal facility, the CSM, France's first above-ground disposal facility for low- and intermediate-level waste, which is now closed; studying and designing disposal facilities for waste as yet without a special facility, that is: Low-level, long-lived waste (LLW-LL), High-level and intermediate-level long-lived waste (HLW, ILW-LL) - the Cigeo project; taking in radioactive waste from hospitals, research laboratories, universities and radioactive objects owned by private individuals (old luminous clocks and watches, health care equipment containing radium, natural laboratory salts, certain minerals, etc.); at the request of the owner or the authorities, cleaning up sites polluted by radioactivity; surveying and listing French radioactive waste and issuing the National Inventory of Radioactive Materials and Waste every three years; informing all members of the public by means of documents, exhibitions, visits to its facilities, etc.; preserving the memory of its centers; promoting and disseminating its know-how outside France. Contents: 1 - Andra, its role, its activities, its funding; 2

Government/Andra 2001/2004 quadrennial contract; Contrat quadriennal 2001/2004 Etat/Andra

Energy Technology Data Exchange (ETDEWEB)

NONE

2002-07-01

The French national agency for the management of radioactive wastes (ANDRA) was created on December 31, 1991 with the objective of carrying out research works in the domain of the long term management of radioactive wastes: research programs, management of waste disposal facilities, realisation and exploitation of underground laboratories for the design and setting up of new disposal facilities, definition of safety rules, conditioning and disposal specifications, inventory and localization of all radioactive wastes inside the French territory. This documents aims at defining the missions of the Andra for the 2001-2004 era, ten years after its creation: classification of radioactive wastes; positioning and missions of the Agency; objectives for the industrial mission (safety, storage and disposal solutions, management solutions, continuation of the inventory work, optimization of disposal costs, memory and surveillance); objectives of the research mission (high scientific level projects, structuration of researches, reinforcement of the coordination between the 3 axes of the 1991 law, exploitation and management of underground laboratories, spreading out of scientific results); objectives of the information mission (inventory and localization of wastes, realization of a reference inventory, contribution to the local information, proposal for a clear and verifiable information); international policy objectives (promotion of contacts and cooperations with foreign partners, representation of the Agency among the big international organizations, punctual missions for the valorization of the Agency competencies); evaluation and quality assurance inside the Agency (safety evaluation, scientific and technical evaluation, quality policy and environment, ethics, contract follow up). (J.S.)

ANDRA - 2012 activity and sustainable development report

International Nuclear Information System (INIS)

Renauld, Valerie; Levert, Anne-Sophie; Muzerelle, Sophie; Cassoli, Emmanuel

2013-07-01

After a brief presentation of the main events during 2012, a recall of the ANDRA's mission (national inventory of radioactive materials and wastes), and a brief presentation of staffing data, this report presents and comments the activities of the ANDRA in the industrial domain (the Cigeo project for deep geological disposal of radioactive wastes, activities of the Aube centres and of the Manche storage centre, perspectives for low-activity long-life wastes, decontamination of polluted sites), in the scientific field (European projects, support to education and training, participation to a colloquium on clays, activities in the field of numerical simulation, activities of the 'Observatoire de l'Environnement'). The next part address the international activities, local commitments (in relationship with the different storage and industrial centres, or in the field of education and training), and activities related to communication and information

Analysis list: lin-13 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available lin-13 Embryo,Larvae + ce10 http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/target/...lin-13.1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/target/lin-13.5.tsv http://dbarchive.bioscience...dbc.jp/kyushu-u/ce10/target/lin-13.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/colo/lin-13.Embryo....tsv,http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/colo/lin-13.Larvae.tsv http://dbarchive.bioscience...dbc.jp/kyushu-u/ce10/colo/Embryo.gml,http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/colo/Larvae.gml ...

In vitro expansion of Lin{sup +} and Lin{sup −} mononuclear cells from human peripheral blood

Energy Technology Data Exchange (ETDEWEB)

Norhaiza, H. Siti; Zarina, Z. A. Intan; Hisham, Z. A. Shahrul [School of Bioscience and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600, Selangor (Malaysia); Rohaya, M. A. W. [Department of Orthodontics, Faculty of Dentistry, Universiti Kebangsaan Malaysia, 50300, Kuala Lumpur (Malaysia)

2013-11-27

Haematopoietic stem cells (HSCs) are used in the therapy of blood disorders due to the ability of these cells to reconstitute haematopoietic lineage cells when transplanted into myeloablative recipients. However, substantial number of cells is required in order for the reconstitution to take place. Since HSCs present in low frequency, larger number of donor is required to accommodate the demand of transplantable HSCs. Therefore, in vitro expansion of HSCs will have profound impact on clinical purposes. The aim of this study was to expand lineage negative (Lin{sup −}) stem cells from human peripheral blood. Total peripheral blood mononuclear cells (PBMNCs) were fractionated from human blood by density gradient centrifugation. Subsequently, PBMNCs were subjected to magnetic assisted cell sorter (MACS) which depletes lineage positive (Lin{sup +}) mononuclear cells expressing lineage positive markers such as CD2, CD3, CD11b, CD14, CD15, CD16, CD19, CD56, CD123, and CD235a to obtained Lin{sup −} cell population. The ability of Lin{sup +} and Lin{sup −} to survive in vitro was explored by culturing both cell populations in complete medium consisting of Alpha-Minimal Essential Medium (AMEM) +10% (v/v) Newborn Calf Serum (NBCS)+ 2% (v/v) pen/strep. In another experiment, Lin{sup +} and Lin{sup −} were cultured with complete medium supplemented with 10ng/mL of the following growth factors: stem cell factor (SCF), interleukin (IL)-3, granulocyte-macrophage colony stimulating factor (GM-CSF), 2IU/mL of Erythropoietin (Epo) and 20ng/mL of IL-6. Three samples were monitored in static culture for 22 days. The expansion potential was assessed by the number of total viable cells, counted by trypan blue exclusion assay. It was found that Lin{sup +} mononuclear cells were not able to survive either in normal proliferation medium or proliferation medium supplemented with cytokines. Similarly, Lin{sup −} stem cells were not able to survive in proliferation medium however

Andra 1997 activity report

International Nuclear Information System (INIS)

1998-07-01

This activity report comprises two parts. The first part describes the missions and activities of the ANDRA (the French agency for the management of radioactive wastes): quality control of wastes produced by EdF, CEA, Cogema and the 1100 other small producers, design, construction and management of storage centres, anticipation and development of new management solutions, research and evaluation studies on deep storage facilities, inventory and control of all radioactive materials present in the French territory. The second part is a presentation of financial data. (J.S.)

Analysis list: lin-35 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available lin-35 Adult,Larvae + ce10 http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/target/l...in-35.1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/target/lin-35.5.tsv http://dbarchive.bioscienced...bc.jp/kyushu-u/ce10/target/lin-35.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/colo/lin-35.Adult.t...sv,http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/colo/lin-35.Larvae.tsv http://dbarchive.bioscience...dbc.jp/kyushu-u/ce10/colo/Adult.gml,http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/colo/Larvae.gml ...

ANDRA - Annual sustainable development and activity report 2011

International Nuclear Information System (INIS)

2012-11-01

After two texts on the themes of change and dialogue signed by ANDRA's CEO and CBA (Chairman of the Board of Administrators), this report proposes a large overview of the French national radioactive waste management Agency, ANDRA, in the fields of governance (missions, installations, institutional representatives, customers, launching of the Meuse/Haute-Marne inter-district development scheme, 2009 report on the Cigeo project), of human resources (place of women and men, payroll, the Customer Industrial Solutions department, a new approach to customer relations, Cigeo project), of public service missions (site cleaning up, containment of radioactive wastes, radium diagnosis), of industry (Cigeo project, Manche disposal facility, very-low-level waste disposal facility in the Aube district, a crane to move a roof-canopy, low- and intermediate-level waste disposal facility in the Aube district, test of crisis communication, ASN inspections), of the environment (permanent environmental observatory, radiological impact of disposal facilities), of scientific policy (strategic research agenda, relationships with higher education, opinion of experts on ANDRA research), of technological research (new experiments in laboratory, patent in metrology, computer tools, geological knowledge and modelling of the Meuse and Haute-Marne districts, radioactive waste behaviour, issues of intellectual property), of experiments and development, of international commitment and relationships (with South Korea, Eastern Europe, Hungary and Morocco, European directive on radioactive wastes), of sustainable development (local contracts, sponsorship and partnership), of dialogue, transparency and communication, of commitment for future generations, and of future perspectives

The State-ANDRA contract of objectives for 2013-2016

International Nuclear Information System (INIS)

Fioraso, Genevieve; Moscovici, Pierre; Gonnot, Francois-Michel; Dupuis, Marie-Claude

2013-05-01

After a brief presentation of the ANDRA and of its missions, this document discusses the context and strategic orientations: results of the 2009-2012 contract, new elements of context, new priorities for public authorities, and strategic orientations. The next part presents the objectives of the new contract. It describes the various roles the ANDRA is to play: a designer and lead contractor possessing a high level research capacity, an exemplary industrialist, a public expert guarantor of the comprehensiveness of solutions for the management of radioactive wastes, a centre of information and dissemination in France and at the international level, and support and management. Appendices propose a table of activities and sponsors, the main milestones of the contract, a contract follow-up indicator

Andra's geologic repository monitoring strategy

International Nuclear Information System (INIS)

Buschaert, S.; Lesoille, S.; Bertrand, J.; Landais, P.

2012-01-01

Document available in extended abstract form only. After having concluded a feasibility study of deep geological disposal for high-level and long-lived radioactive waste in 2005, Andra was charged by the Planning Act no. 2006-739 to design and create an industrial site for geological disposal called Cigeo which must be reversible for at least a century-long period. The French Safety Guide recommends that Andra develop a monitoring program to be implemented at repository construction and conducted until closure, and possibly after closure, with the aim to confirming prior expectations and enhancing knowledge of relevant processes. This abstract focuses on underground structure monitoring. The monitoring system is based on a combination of in-situ instrumentation and nondestructive methods to obtain the required level of reliable performance. To optimize the device distribution, we take into account both the repetitive design of disposal cells and the homogeneity of the rock properties. This resulted in distinguishing pilot disposal cells that are highly instrumented and standard disposal cells where the instrumentation density could be reduced; monitoring will rely mostly on robotic nondestructive evaluations. If monitoring technologies do not comply with all monitoring objectives, real withdrawal tests of high level wastes in some pilot disposal cells are also planned to provide the possibility of carrying out visual inspection, destructive analyses and samplings on construction materials. Such cells are planned to be dismantled because of the potential disturbance of their component performances from the testing process. Based on this overall strategy, Andra has analyzed the technical requirements that must be met by its monitoring equipment. First, these must be able to provide information on key THMCR (Thermal- Hydraulic-Mechanical-Chemical and Radiological) processes, to provide a three-dimensional image of a disposal component's behavior and thus to understand

75 FR 38718 - Safety Zone; Sault Sainte Marie 4th of July Fireworks, St. Mary's River, Sault Sainte Marie, MI

Science.gov (United States)

2010-07-06

... temporary safety zone on the St. Mary's River, Sault Sainte Marie, Michigan. This zone is intended to..., St. Mary's River, Sault Sainte Marie, MI (a) Location. The following area is a temporary safety zone...-AA00 Safety Zone; Sault Sainte Marie 4th of July Fireworks, St. Mary's River, Sault Sainte Marie, MI...

Management of uncertainties and the role of risk in Andra programme

International Nuclear Information System (INIS)

Grevoz, A.

2004-01-01

This paper aims at presenting some aspects of the management of uncertainties in the programmes of Andra for the study of a deep geological repository for high level, long-lived wastes. After presenting very briefly the context of risk-management in the French safety rules, it will discuss how Andra has attempted to link the notions of uncertainties and risk in its 'Dossier 2001' for the clay medium, how this could be made compatible with a deterministic safety approach, what feedback it got from this first exercise, and what are the perspectives for future work. (author)

Andra long term memory project - 59277

International Nuclear Information System (INIS)

Charton, Patrick; Boissier, Fabrice; Martin, Guillaume

2012-01-01

Document available in abstract form only. Full text of publication follows: Long term memory of repositories is required by safety, reversibility and social expectations. Thus Andra has implemented since 2010 a long-term memory project to reinforce and diversify its current arrangements in this field, as well as to explore opportunities to extend memory keeping over thousands years. The project includes opportunity studies of dedicated facilities. The 'Ecotheque' and 'Geotheque' projects contribute to memory respectively through environmental and geological samples preservation. The options of creating (i) an archive centre for Andra's interim and permanent archives, (ii) an artist center to study the contribution of arts to memory preservation, (iii) a museum of radioactive waste disposal history and technology (radium industry..., sea disposal, current solutions...) are considered. Other studies provided by the project examine our heritage. This includes the continuity of languages and symbolic systems, the continuity of writing and engraving methods, the archaeology of landscapes (memory of the earths evolution, multi-century memory of industrial and agricultural landscapes), the archaeology practices (how might a future archaeologist be interested in our current activity?), the preservation of historical sites and industrial memory, the continuity of institutional organizations, the memory and history of science evolution as well as broad history

MYCN-driven regulatory mechanisms controlling LIN28B in neuroblastoma

Science.gov (United States)

Beckers, Anneleen; Van Peer, Gert; Carter, Daniel R.; Gartlgruber, Moritz; Herrmann, Carl; Agarwal, Saurabh; Helsmoortel, Hetty H.; Althoff, Kristina; Molenaar, Jan J.; Cheung, Belamy B.; Schulte, Johannes H.; Benoit, Yves; Shohet, Jason M.; Westermann, Frank; Marshall, Glenn M.; Vandesompele, Jo; De Preter, Katleen; Speleman, Frank

2016-01-01

LIN28B has been identified as an oncogene in various tumor entities, including neuroblastoma, a childhood cancer that originates from neural crest-derived cells, and is characterized by amplification of the MYCN oncogene. Recently, elevated LIN28B expression levels were shown to contribute to neuroblastoma tumorigenesis via let-7 dependent de-repression of MYCN. However, additional insight in the regulation of LIN28B in neuroblastoma is lacking. Therefore, we have performed a comprehensive analysis of the regulation of LIN28B in neuroblastoma, with a specific focus on the contribution of miRNAs. We show that MYCN regulates LIN28B expression in neuroblastoma tumors via two distinct parallel mechanisms. First, through an unbiased LIN28B-3′UTR reporter screen, we found that miR-26a-5p and miR-26b-5p regulate LIN28B expression. Next, we demonstrated that MYCN indirectly affects the expression of miR-26a-5p, and hence regulates LIN28B, therefor establishing a MYCN-miR-26a-5p-LIN28B regulatory axis. Second, we provide evidence that MYCN regulates LIN28B expression via interaction with the LIN28B promotor, establishing a direct MYCN-LIN28B regulatory axis. We believe that these findings mark LIN28B as an important effector of the MYCN oncogenic phenotype and underlines the importance of MYCN-regulated miRNAs in establishing the MYCN-driven oncogenic process. PMID:26123663

Where, when, how: the place of radioactive wastes in France. Andra, 1998 activity report; Ou, quand, comment: la place des dechets radioactifs en France. Andra, rapport d'activite 1998

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-07-01

The 1998 activity report of the French national agency of radioactive wastes (Andra) presents successively: the role and missions of the Andra (history, status of radioactive wastes in France, surface storage and know-how, underground research laboratories, site selection and public information); the aspects of safety (inventory, identification and labelling of wastes, environmental policy, public relation, safety rules and reports, information storage); the scientific programs (collaborations, financing, site studies, rock mechanics and reversibility of storage, design of storage facilities, services); financial report. (J.S.)

Lin28a regulates germ cell pool size and fertility

Science.gov (United States)

Shinoda, Gen; de Soysa, T. Yvanka; Seligson, Marc T.; Yabuuchi, Akiko; Fujiwara, Yuko; Huang, Pei Yi; Hagan, John P.; Gregory, Richard I.; Moss, Eric G.; Daley, George Q.

2013-01-01

Overexpression of LIN28A is associated with human germ cell tumors and promotes primordial germ cell (PGC) development from embryonic stem cells in vitro and in chimeric mice. Knockdown of Lin28a inhibits PGC development in vitro, but how constitutional Lin28a deficiency affects the mammalian reproductive system in vivo remains unknown. Here, we generated Lin28a knockout (KO) mice and found that Lin28a deficiency compromises the size of the germ cell pool in both males and females by affecting PGC proliferation during embryogenesis. Interestingly however, in Lin28a KO males the germ cell pool partially recovers during postnatal expansion, while fertility remains impaired in both males and females mated to wild type mice. Embryonic overexpression of let-7, a microRNA negatively regulated by Lin28a, reduces the germ cell pool, corroborating the role of the Lin28a/let-7 axis in regulating the germ lineage. PMID:23378032

Government/Andra 2001/2004 quadrennial contract

International Nuclear Information System (INIS)

2002-01-01

The French national agency for the management of radioactive wastes (ANDRA) was created on December 31, 1991 with the objective of carrying out research works in the domain of the long term management of radioactive wastes: research programs, management of waste disposal facilities, realisation and exploitation of underground laboratories for the design and setting up of new disposal facilities, definition of safety rules, conditioning and disposal specifications, inventory and localization of all radioactive wastes inside the French territory. This documents aims at defining the missions of the Andra for the 2001-2004 era, ten years after its creation: classification of radioactive wastes; positioning and missions of the Agency; objectives for the industrial mission (safety, storage and disposal solutions, management solutions, continuation of the inventory work, optimization of disposal costs, memory and surveillance); objectives of the research mission (high scientific level projects, structuration of researches, reinforcement of the coordination between the 3 axes of the 1991 law, exploitation and management of underground laboratories, spreading out of scientific results); objectives of the information mission (inventory and localization of wastes, realization of a reference inventory, contribution to the local information, proposal for a clear and verifiable information); international policy objectives (promotion of contacts and cooperations with foreign partners, representation of the Agency among the big international organizations, punctual missions for the valorization of the Agency competencies); evaluation and quality assurance inside the Agency (safety evaluation, scientific and technical evaluation, quality policy and environment, ethics, contract follow up). (J.S.)

The Lin28/let-7 axis regulates glucose metabolism

Science.gov (United States)

Zhu, Hao; Shyh-Chang, Ng; Segrè, Ayellet V.; Shinoda, Gen; Shah, Samar P.; Einhorn, William S.; Takeuchi, Ayumu; Engreitz, Jesse M.; Hagan, John P.; Kharas, Michael G; Urbach, Achia; Thornton, James E.; Triboulet, Robinson; Gregory, Richard I.; Altshuler, David; Daley, George Q.

2012-01-01

SUMMARY The let-7 tumor suppressor microRNAs are known for their regulation of oncogenes, while the RNA-binding proteins Lin28a/b promote malignancy by blocking let-7 biogenesis. In studies of the Lin28/let-7 pathway, we discovered unexpected roles in regulating metabolism. When overexpressed in mice, both Lin28a and LIN28B promoted an insulin-sensitized state that resisted high fat diet-induced diabetes, whereas muscle-specific loss of Lin28a and overexpression of let-7 resulted in insulin resistance and impaired glucose tolerance. These phenomena occurred in part through let-7-mediated repression of multiple components of the insulin-PI3K-mTOR pathway, including IGF1R, INSR, and IRS2. The mTOR inhibitor rapamycin abrogated the enhanced glucose uptake and insulin-sensitivity conferred by Lin28a in vitro and in vivo. In addition, we found that let-7 targets were enriched for genes that contain SNPs associated with type 2 diabetes and fasting glucose in human genome-wide association studies. These data establish the Lin28/let-7 pathway as a central regulator of mammalian glucose metabolism. PMID:21962509

ANDRA's Management report and financial statement December 2008

International Nuclear Information System (INIS)

2008-01-01

This management report indicates the main operation events in the activity of the ANDRA (the French national Agency for radioactive waste management) during 2008, and of its waste storage centres. It comments the evolution of the various characteristic figures (production, personnel, financial result, certification), and reports the evolution of two projects (the HA-MAVL project for the creation of a storage centre for high- and intermediate-level long-life wastes, and the FA-VL project for the creation of a storage centre for low-level long-life wastes). It reviews ANDRA's industrial activity evolution, that is the operation of several storage centres and the activities related to small waste producers and polluted sites. It comments the level and the evolution of the public subside, briefly describes other activities (national inventory of radioactive materials and wastes, activity at the international level), the financing of future nuclear loads, the action for a sustainable development, the prospective evolution for 2009. In a second part, after the financial statement tables, the report comments these financial results. The different authorities are presented and the official auditor's report concludes this document

Where, when, how: the place of radioactive wastes in France. Andra, 1998 activity report

International Nuclear Information System (INIS)

1998-01-01

The 1998 activity report of the French national agency of radioactive wastes (Andra) presents successively: the role and missions of the Andra (history, status of radioactive wastes in France, surface storage and know-how, underground research laboratories, site selection and public information); the aspects of safety (inventory, identification and labelling of wastes, environmental policy, public relation, safety rules and reports, information storage); the scientific programs (collaborations, financing, site studies, rock mechanics and reversibility of storage, design of storage facilities, services); financial report. (J.S.)

Intermediate, low, and very low level waste management at ANDRA (agence nationale pour la gestion des dechets radioactifs) in France

International Nuclear Information System (INIS)

Senoo, Muneaki

2005-01-01

On 28th September in 2004, RANDEC invited Mr. Jean-Louis Tison from ANDRA as a lecturer of the special session of the 16th RANDEC Annual Symposium. An ANDRA-RANDEC technical meeting was held on the next day, where Mr. Vincent Carlier invited from ANDRA, too participated. Here, present status of intermediate, low, and very low level waste management in France is reviewed based on the information which were obtained from the special session of the 16th RANDEC Annual Symposium and the ANDRA-RANDEC technical meeting. In France, ANDRA is implementing radioactive waste management under the following policy; 'Intermediate, low, and very-low-level (ILVLL) waste is managed in order to establish as soon as possible a final disposal system, the temporary or long term storage option being considered only for the high-level waste (HLW) such as the vitrified fission products or particular materials such as some sealed sources for which no final disposal solution still exists.' The Agency is financed on the basis of the 'polluter-pays' principle and contracts its services directly with waste owners. (author)

Refinements to calandria tube - liquid injection nozzle (CT-LIN) contact assessments

International Nuclear Information System (INIS)

Sedran, P.J.

2012-01-01

In recent years, the issue of CT-LIN contact, which first gained attention in 1989, has been addressed through CT-LIN gap measurements, followed by analytical predictions of time-to-contact. CT-LIN time-to-contact predictions have been preformed independently by CPUS Limited for Point Lepreau and Gentilly-2 and by AECL Sheridan Park (now Candu Energy Inc.) for Bruce Power and Gentilly-2. Both companies used the CDEPTH code in combination with CT-LIN gap measurements. Subsequent to the assessments for Point Lepreau and Gentilly-2, a recommended approach for future assessments was presented at the 2008 CANDU maintenance conference. Since that time, a number of refinements to the overall strategy for predicting CT-LIN time-to-contact have been developed and are outlined in this paper. The refinements include: 1. The use of ultrasonic LIN elevation measurements to confirm LIN creep sag behaviour 2. The development of a non-linear empirical CT Creep Sag Model 3. The development of a rationale for discrepancies observed in repeated optical CT-LIN gap measurements and a discussion of alternative CT-LIN gap measurements With these refinements, more accurate CT-LIN time-to-contact predictions can be obtained. For stations that plan to refurbish by 210,000 EFPH, the improvement in time-to-contact predictions resulting from the fore mentioned refinements will not be of any real benefit.. However, for stations that are planning life extensions in order to operate beyond 210,000 EFPH, CT-LIN contact will be an issue. For these stations, improvements in CT-LIN contact time predictions would be beneficial. This paper presents a summary of the proposed refinements and demonstrates how they would impact CT-LIN time-to-contact predictions. (author)

Building Bridges between Hard and Soft Knowledge: The Co-production of Andra's Socio-technical Approach on Reversibility

International Nuclear Information System (INIS)

Aparicio, Luis

2012-01-01

At the crossroads of political decision making and scientific and technical design, the concept of reversibility appeared in French law with the Waste Act dated 30 December 1991. The study of possibilities for reversible or irreversible disposal within deep geological formations of HLW waste was assigned to the National Radioactive Waste Management Agency (Andra) which, through the same act, became an independent public institution. Fifteen years later, the Planning Act dated 28 June 2006 requests Andra to file a licence application for a reversible disposal facility to be reviewed by 2015, after a public debate. It also states that a new law will have to prescribe the exact reversibility conditions of disposal before a license is granted. As a result of this legal framing, the design and the implementation of a reversible disposal facility - Andra's CIGEO project - are placed in France within a new innovation regime. Based upon the progressive elaboration of socio-technical compromises to make radioactive waste governable, Andra's project robustness is measured both in technical and social terms. Matters of concern include, among others, local insertion and land-use planning, techno-economic optimisation, safety analysis and performance assessment, scientific and technical progress, social acceptability.. Moreover, the reversible principle implies that Andra must grant future generations the possibility of intervention for at least one hundred years. Defining a reversible deep disposal facility means therefore, for Andra, mobilising much more than technical expertise; it consists also in a kind of mediation work that shapes the project as a public issue. Traditional frontiers between experts, citizens and policy makers are thus blurred in this new regime of innovation. Other than scientific and technical accuracy, Andra's project capacity to hold up multiple perspectives and resisting their respective criticisms will also be assessed. Andra is therefore committed

Lin28 sustains early renal progenitors and induces Wilms tumor

Science.gov (United States)

Urbach, Achia; Yermalovich, Alena; Zhang, Jin; Spina, Catherine S.; Zhu, Hao; Perez-Atayde, Antonio R.; Shukrun, Rachel; Charlton, Jocelyn; Sebire, Neil; Mifsud, William; Dekel, Benjamin; Pritchard-Jones, Kathy; Daley, George Q.

2014-01-01

Wilms Tumor, the most common pediatric kidney cancer, evolves from the failure of terminal differentiation of the embryonic kidney. Here we show that overexpression of the heterochronic regulator Lin28 during kidney development in mice markedly expands nephrogenic progenitors by blocking their final wave of differentiation, ultimately resulting in a pathology highly reminiscent of Wilms tumor. Using lineage-specific promoters to target Lin28 to specific cell types, we observed Wilms tumor only when Lin28 is aberrantly expressed in multiple derivatives of the intermediate mesoderm, implicating the cell of origin as a multipotential renal progenitor. We show that withdrawal of Lin28 expression reverts tumorigenesis and markedly expands the numbers of glomerulus-like structures and that tumor formation is suppressed by enforced expression of Let-7 microRNA. Finally, we demonstrate overexpression of the LIN28B paralog in a significant percentage of human Wilms tumor. Our data thus implicate the Lin28/Let-7 pathway in kidney development and tumorigenesis. PMID:24732380

Marie Curie's heritage

International Nuclear Information System (INIS)

Pajot, Ph.; Schaeffer, A.; Barhelemy, P.

2011-01-01

This issue is almost entirely dedicated to Marie Curie. The first part gives the main steps of her life, an article draws a parallel with Lise Meitner's life, another describes the instruments Marie Curie used to measure radioactivity and a third one gives an idea of the network of scientists she integrated. The second part presents the scientific heritage of Marie Curie, first the curietherapy then medical imaging and radiocarbon dating. The third part presents other achievements and commitments of Marie Curie concerning the place of women in a modern society and the social changes trough scientific progress. (A.C.)

Assessment of the 2005-2008 State-ANDRA contract

International Nuclear Information System (INIS)

2008-01-01

This report proposes an assessment of the activity of the ANDRA (French national Agency for radioactive waste management) with respect to its different missions, i.e., an industrial mission, a research mission, and an information mission, but also with respect to evaluation practices and to its human resources. For each of these main issues, this report recalls the objectives as they were defined in the 2005-2008 contract and indicates what has been done about

PNGMDR 2013-2015. ANDRA's opinion on the development of sector of recycling of VLA ferrous metallic waste

International Nuclear Information System (INIS)

2014-01-01

The scope of this report is to state the ANDRA's opinion on the recycling of very-low-level metallic wastes, and mainly ferrous metallic wastes which are the main stream of them. After having evoked a study jointly performed by EDF, AREVA, the CEA and the ANDRA to assess the technical and economic feasibility of a valorisation of very-low-level metallic wastes in the nuclear sector, this study proposes an assessment of ferrous metals which might be recycled over about thirty years. After having outlined the strong motivation of the ANDRA for such a recycling, the report proposes an overview of the heterogeneous stream of metallic wastes, by distinguishing scrap materials from very heterogeneous origins like those brought to the Cires storage centre, and those with more homogeneous origins (for example, from dismantling activities). The next part proposes an overview of various non coordinated initiatives, notably by the ANDRA, on different storage sites. The report identifies the keys for a successful recycling of contaminated metals in Europe, and the main challenges for the recycling of very-low-level ferrous metal in France (in competition with direct storage, and with the application of the risk-related regulation for some metallic wastes). Some proposals made by the ANDRA are then stated: a reference industrial scheme, and a coordination of actors under the auspices of the State

lin-12 Notch functions in the adult nervous system of C. elegans

Directory of Open Access Journals (Sweden)

Tucey Tim M

2005-07-01

Full Text Available Abstract Background Notch signaling pathways are conserved across species and traditionally have been implicated in cell fate determination during embryonic development. Notch signaling components are also expressed postdevelopmentally in the brains of adult mice and Drosophila. Recent studies suggest that Notch signaling may play a role in the physiological, rather than developmental, regulation of neurons. Here, we investigate a new non-developmental role for Caenorhabditis elegans lin-12 Notch signaling in neurons regulating the spontaneous reversal rate during locomotion. Results The spontaneous reversal rate of C. elegans during normal locomotion is constant. Both lin-12 gain and loss of function mutant animals had significantly increased reversal rates compared to wild type controls. These defects were caused by lin-12 activity, because the loss of function defect could be rescued by a wild type lin-12 transgene. Furthermore, overexpression of lin-12 recapitulated the gain-of-function defect. Increasing or decreasing lin-12 activity in the postdevelopmental adult animal was sufficient to rapidly and reversibly increase reversals, thereby excluding a developmental role for lin-12. Although lin-12 is expressed in the vulval and somatic gonad lineages, we find that these tissues play no role in regulating reversal rates. In contrast, altering lin-12 activity specifically in the nervous system was sufficient to increase reversals. These behavioral changes require components of the canonical lin-12 signaling cascade, including the ligand lag-2 and the transcriptional effector lag-1. Finally, the C. elegans AMPA/kainate glutamate receptor homolog glr-1 shows strong genetic interactions with lin-12, suggesting that glr-1 and/or other glutamate gated channels may be targets of lin-12 regulation. Conclusion Our results demonstrate a neuronal role for lin-12 Notch in C. elegans and suggest that lin-12 acutely regulates neuronal physiology to

Geoscientific (GEO) database of the Andra Meuse / Haute-Marne research center

International Nuclear Information System (INIS)

Tabani, P.; Hemet, P.; Hermand, G.; Delay, J.; Auriere, C.

2010-01-01

Document available in extended abstract form only. The GEO database (geo-scientific database of the Meuse/Haute-Marne Center) is a tool developed by Andra, with a view to group in a secured computer form all data related to the acquisition of in situ and laboratory measurements made on solid and fluid samples. This database has three main functions: - Acquisition and management of data and computer files related to geological, geomechanical, hydrogeological and geochemical measurements on solid and fluid samples and in situ measurements (logging, on sample measurements, geological logs, etc). - Available consultation by the staff on Andra's intranet network for selective viewing of data linked to a borehole and/or a sample and for making computations and graphs on sets of laboratory measurements related to a sample. - Physical management of fluid and solid samples stored in a 'core library' in order to localize a sample, follow-up its movement out of the 'core library' to an organization, and carry out regular inventories. The GEO database is a relational Oracle data base. It is installed on a data server which stores information and manages the users' transactions. The users can consult, download and exploit data from any computer connected to the Andra network or Internet. Management of the access rights is made through a login/ password. Four geo-scientific explanations are linked to the Geo database, they are: - The Geosciences portal: The Geosciences portal is a web Intranet application accessible from the ANDRA network. It does not require a particular installation from the client and is accessible through the Internet navigator. A SQL Server Express database manages the users and access rights to the application. This application is used for the acquisition of hydrogeological and geochemical data collected on the field and on fluid samples, as well as data related to scientific work carried out at surface level or in drifts

Selective blockade of microRNA processing by Lin-28

Science.gov (United States)

Viswanathan, Srinivas R.; Daley, George Q.; Gregory, Richard I.

2012-01-01

MicroRNAs (miRNAs) play critical roles in development, and dysregulation of miRNA expression has been observed in human malignancies. Recent evidence suggests that the processing of several primary miRNA transcripts (pri-miRNAs) is blocked post-transcriptionally in embryonic stem (ES) cells, embryonal carcinoma (EC) cells, and primary tumors. Here we show that Lin-28, a developmentally regulated RNA-binding protein, selectively blocks the processing of pri-let-7 miRNAs in embryonic cells. Using in vitro and in vivo studies, we demonstrate that Lin-28 is necessary and sufficient for blocking Microprocessor-mediated cleavage of pri-let-7 miRNAs. Our results identify Lin-28 as a negative regulator of miRNA biogenesis and suggest that Lin-28 may play a central role in blocking miRNA-mediated differentiation in stem cells and certain cancers. PMID:18292307

Kaks Mari Vaalas / Eha Komissarov

Index Scriptorium Estoniae

Komissarov, Eha, 1947-

1999-01-01

9. nov.-st galeriis 'Vaal' Mari Roosvaldi maalinäitus 'Persoon'; 10. nov.-st galerii keldrisaalis Mari Kurismaa 'Matemaatika ja metafüüsika'. Mari Roosvaldi kollaazhides on ühendatud maal ja foto.

Multiple transcription factors directly regulate Hox gene lin-39 expression in ventral hypodermal cells of the C. elegans embryo and larva, including the hypodermal fate regulators LIN-26 and ELT-6.

Science.gov (United States)

Liu, Wan-Ju; Reece-Hoyes, John S; Walhout, Albertha J M; Eisenmann, David M

2014-05-13

Hox genes encode master regulators of regional fate specification during early metazoan development. Much is known about the initiation and regulation of Hox gene expression in Drosophila and vertebrates, but less is known in the non-arthropod invertebrate model system, C. elegans. The C. elegans Hox gene lin-39 is required for correct fate specification in the midbody region, including the Vulval Precursor Cells (VPCs). To better understand lin-39 regulation and function, we aimed to identify transcription factors necessary for lin-39 expression in the VPCs, and in particular sought factors that initiate lin-39 expression in the embryo. We used the yeast one-hybrid (Y1H) method to screen for factors that bound to 13 fragments from the lin-39 region: twelve fragments contained sequences conserved between C. elegans and two other nematode species, while one fragment was known to drive reporter gene expression in the early embryo in cells that generate the VPCs. Sixteen transcription factors that bind to eight lin-39 genomic fragments were identified in yeast, and we characterized several factors by verifying their physical interactions in vitro, and showing that reduction of their function leads to alterations in lin-39 levels and lin-39::GFP reporter expression in vivo. Three factors, the orphan nuclear hormone receptor NHR-43, the hypodermal fate regulator LIN-26, and the GATA factor ELT-6 positively regulate lin-39 expression in the embryonic precursors to the VPCs. In particular, ELT-6 interacts with an enhancer that drives GFP expression in the early embryo, and the ELT-6 site we identified is necessary for proper embryonic expression. These three factors, along with the factors ZTF-17, BED-3 and TBX-9, also positively regulate lin-39 expression in the larval VPCs. These results significantly expand the number of factors known to directly bind and regulate lin-39 expression, identify the first factors required for lin-39 expression in the embryo, and hint at a

The Lin28/let-7 Axis Regulates Glucose Metabolism

NARCIS (Netherlands)

Zhu, Hao; Shyh-Chang, Ng; Segre, Ayellet V.; Shinoda, Gen; Shah, Samar P.; Einhorn, William S.; Takeuchi, Ayumu; Engreitz, Jesse M.; Hagan, John P.; Kharas, Michael G.; Urbach, Achia; Thornton, James E.; Triboulet, Robinson; Gregory, Richard I.; Altshuler, David; Daley, George Q.

2011-01-01

The let-7 tumor suppressor microRNAs are known for their regulation of oncogenes, while the RNA-binding proteins Lin28a/b promote malignancy by inhibiting let-7 biogenesis. We have uncovered unexpected roles for the Lin28/let-7 pathway in regulating-metabolism. When overexpressed in mice, both

Mary M Mader

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education. Mary M Mader. Articles written in Resonance – Journal of Science Education. Volume 2 Issue 1 January 1997 pp 53-59 General Article. Fostering Creativity in Students A Short Synthesis Project for the Organic Chemistry Laboratory · Mary M Mader Charles A ...

ANDRA - Management report and financial statements 2011

International Nuclear Information System (INIS)

2012-07-01

The first part of this ANDRA report (French National Agency for radioactive waste management) comments the global financial balance and the evolution of the personnel. It briefly presents the CIGEO project, the FA-VL project (low activity and long life). It presents the various industrial activities such as surface storage centres, nuclear activities outside the electronuclear sector (waste collection, polluted sites, national inventory of radioactive wastes). It evokes public subsidies, investments, and the international activity. It discusses the securing of the future nuclear burden financing. It briefly indicates the main objectives for 2012. The second part contains the different tables of the financial statements. These accounts are discussed and commented in appendix

Fetal deficiency of Lin28 programs life-long aberrations in growth and glucose metabolism

Science.gov (United States)

Shinoda, Gen; Shyh-Chang, Ng; de Soysa, T. Yvanka; Zhu, Hao; Seligson, Marc T.; Shah, Samar P.; Abo-Sido, Nora; Yabuuchi, Akiko; Hagan, John P.; Gregory, Richard I.; Asara, John M.; Cantley, Lewis C.; Moss, Eric G.; Daley, George Q.

2013-01-01

LIN28A/B are RNA binding proteins implicated by genetic association studies in human growth and glucose metabolism. Mice with ectopic over-expression of Lin28a have shown related phenotypes. Here we describe the first comprehensive analysis of the physiologic consequences of Lin28a and Lin28b deficiency in knockout (KO) mice. Lin28a/b-deficiency led to dwarfism starting at different ages, and compound gene deletions showed a cumulative dosage effect on organismal growth. Conditional gene deletion at specific developmental stages revealed that fetal but neither neonatal nor adult deficiency resulted in growth defects and aberrations in glucose metabolism. Tissue-specific KO mice implicated skeletal muscle-deficiency in the abnormal programming of adult growth and metabolism. The effects of Lin28b KO can be rescued by Tsc1 haplo-insufficiency in skeletal muscles. Our data implicate fetal expression of Lin28a/b in the regulation of life-long effects on metabolism and growth, and demonstrate that fetal Lin28b acts at least in part via mTORC1 signaling. PMID:23666760

In vitro expansion of Lin+ and Lin− mononuclear cells from human peripheral blood

International Nuclear Information System (INIS)

Norhaiza, H. Siti; Zarina, Z. A. Intan; Hisham, Z. A. Shahrul; Rohaya, M. A. W.

2013-01-01

Haematopoietic stem cells (HSCs) are used in the therapy of blood disorders due to the ability of these cells to reconstitute haematopoietic lineage cells when transplanted into myeloablative recipients. However, substantial number of cells is required in order for the reconstitution to take place. Since HSCs present in low frequency, larger number of donor is required to accommodate the demand of transplantable HSCs. Therefore, in vitro expansion of HSCs will have profound impact on clinical purposes. The aim of this study was to expand lineage negative (Lin − ) stem cells from human peripheral blood. Total peripheral blood mononuclear cells (PBMNCs) were fractionated from human blood by density gradient centrifugation. Subsequently, PBMNCs were subjected to magnetic assisted cell sorter (MACS) which depletes lineage positive (Lin + ) mononuclear cells expressing lineage positive markers such as CD2, CD3, CD11b, CD14, CD15, CD16, CD19, CD56, CD123, and CD235a to obtained Lin − cell population. The ability of Lin + and Lin − to survive in vitro was explored by culturing both cell populations in complete medium consisting of Alpha-Minimal Essential Medium (AMEM) +10% (v/v) Newborn Calf Serum (NBCS)+ 2% (v/v) pen/strep. In another experiment, Lin + and Lin − were cultured with complete medium supplemented with 10ng/mL of the following growth factors: stem cell factor (SCF), interleukin (IL)-3, granulocyte-macrophage colony stimulating factor (GM-CSF), 2IU/mL of Erythropoietin (Epo) and 20ng/mL of IL-6. Three samples were monitored in static culture for 22 days. The expansion potential was assessed by the number of total viable cells, counted by trypan blue exclusion assay. It was found that Lin + mononuclear cells were not able to survive either in normal proliferation medium or proliferation medium supplemented with cytokines. Similarly, Lin − stem cells were not able to survive in proliferation medium however, addition of cytokines into the proliferation

Inauguration of the ANDRA atmospheric station in Houdelaincourt; Inauguration de la station atmospherique de l'Andra a Houdelaincourt

Energy Technology Data Exchange (ETDEWEB)

NONE

2011-07-01

This document briefly presents the atmospheric monitoring station inaugurated in Houdelaincourt (Meuse) and installed by the ANDRA within the frame of the ICOS (Integrated Carbon Observing System) European infrastructure project which aims at developing air and greenhouse gas monitoring over Europe. It also recalls that this station is part of a set of means of monitoring, experimentation and protection of the environment within the frame of high and medium level nuclear waste storage project in Meuse and Haute-Marne. The document also proposes brief presentations of the different actors involved in the creation of this station: the LSCE (laboratory of sciences of climate and environment), Meteo-France, Air Lorraine, the IRSN, and the LGGE (laboratory of glaciology and geophysics of the environment)

Lin Receives 2010 Natural Hazards Focus Group Award for Graduate Research

Science.gov (United States)

2010-11-01

Ning Lin has been awarded the Natural Hazards Focus Group Award for Graduate Research, given annually to a recent Ph.D. recipient for outstanding contributions to natural hazards research. Lin's thesis is entitled “Multi-hazard risk analysis related to hurricanes.” She is scheduled to present an invited talk in the Extreme Natural Events: Modeling, Prediction, and Mitigation session (NH20) during the 2010 AGU Fall Meeting, held 13-17 December in San Francisco, Calif. Lin will be formally presented with the award at the Natural Hazards focus group reception on 14 December 2010.

Lin28b is sufficient to drive liver cancer and necessary for its maintenance in murine models

Science.gov (United States)

Nguyen, Liem H.; Robinton, Daisy A.; Seligson, Marc; Wu, Linwei; Li, Lin; Rakheja, Dinesh; Comerford, Sarah; Ramezani, Saleh; Sun, Xiankai; Parikh, Monisha; Yang, Erin; Powers, John T.; Shinoda, Gen; Shah, Samar; Hammer, Robert; Daley, George Q.; Zhu, Hao

2014-01-01

SUMMARY Lin28a/b are RNA-binding proteins that influence stem cell maintenance, metabolism, and oncogenesis. Poorly differentiated, aggressive cancers often overexpress Lin28, but its role in tumor initiation or maintenance has not been definitively addressed. We report that LIN28B overexpression is sufficient to initiate hepatoblastoma and hepatocellular carcinoma in murine models. We also detected Lin28b overexpression in MYC-driven hepatoblastomas, and liver-specific deletion of Lin28a/b reduced tumor burden, extended latency, and prolonged survival. Both intravenous siRNA against Lin28b and conditional Lin28b deletion reduced tumor burden and prolonged survival. Igf2bp proteins are upregulated and Igf2bp3 is required in the context of LIN28B overexpression to promote growth. Thus, multiple murine models demonstrate that Lin28b is both sufficient to initiate liver cancer and necessary for its maintenance. PMID:25117712

ANDRA's Centre de l'Aube: Design, construction, operation of a state of the art surface disposal facility for low and intermediate level waste

International Nuclear Information System (INIS)

Potier, J.M.

2001-01-01

The ANDRA's Centre de I'Aube disposal facility for low and intermediate level radioactive waste may be considered as a state-of-the-art repository. Since its implementation in the early nineties, the French facility has been used as a model by many countries worldwide for the surface disposal of radioactive waste. The disposal concept developed by ANDRA, the French Radioactive Waste Management Agency, consists of a multiple-barrier system designed to isolate radioactivity and provide protection to the public and to the environment. Waste operations at ANDRA's Centre de I'Aube are largely automated to ensure better protection to site workers. The paper reviews all aspects of the repository implementation: siting, design, construction, operation and future closure, and environmental monitoring. (author)

The storage of nuclear wastes; General problematic of radioactive waste management; The currently operated ANDRA's storage centres in France; The Aube storage centre (CSA) and the industrial centre for gathering, warehousing and storage (Cires); The Cigeo project - Industrial centre of radioactive waste storage in deep geological layers; From R and D to innovation within the ANDRA

International Nuclear Information System (INIS)

Abadie, Pierre-Marie; Tallec, Michele; Legee, Frederic; Krieguer, Jean-Marie; Plas, Frederic

2016-01-01

This publication proposes a set of four articles which address various aspects related to the storage of nuclear wastes. The authors respectively propose an overview of the general problematic of nuclear waste management, a detailed description of existing storage sites which are currently operated by the ANDRA with a focus on the Aube storage centre or CSA, and on the industrial centre for gathering, warehousing and storage or Cires (The currently operated ANDRA's storage centres in France - The Aube Storage Centre or CSA, and the Industrial Centre for Regrouping, Warehousing and Storage or CIRES), a comprehensive overview of the current status of the Cigeo project which could become one of the most important technological works in France (The Cigeo project - Industrial centre of radioactive waste storage in deep geological layers), and a presentation showing how the ANDRA is involved in R and D activities and innovation (From R and D to innovation within the ANDRA)

Marie Curie: Physicist and Woman

Science.gov (United States)

Howes, Ruth

Marie Sklodowska was born in Warsaw on November 7, 1867. Girls were not allowed to attend college in Poland, so Marie found a well-paying post as a governess in rural village which she held for three years while helping her older sister complete medical school in Paris. Then Marie moved to Paris and graduated first in her class at the Sorbonne with a master's degree in physics in 1893. In 1895, she married the talented young physicist, Pierre Curie. Marie decided to investigate the radioactive components of the mineral pitchblende for her dissertation. The work involved chemical analysis of a ton of material in an unheated shed. Pierre joined her and at the end of 1898, the Curies announced the discovery of radium and polonium. Through 1899, Marie labored to measure the atomic weight of radium. In 1903, Marie earned her doctorate, the first for a woman in France, and the Curies split the Nobel Prize in Physics with Henri Becquerel. They became widely known, besieged by the press and frequently invited to make presentations and be awarded honors. They hated fame and both suffered bad health. In April, 1906, Pierre Curie was struck by a wagon and killed instantly. Marie was left as a single mother with two young daughters. Fortunately, the Sorbonne hired her to fill Pierre's position. In 1911, she was rejected for membership in the French Academy of Science because she was a woman. Also in 1911, she was accused of having an affair with a married French physicist Paul Langevin. The resulting scandal hit the press and brought angry mobs to her home. In the middle of this hullaballoo, she was informed that she had won a second Nobel Prize, this time in Chemistry. When World War I broke out, Marie mounted x-ray units on cars and became a heroine. She visited the United States in 1921 where President Harding presented her with a gram of radium. She continued her scientific studies in spite of declining health until her death in 1934. Professor Emerita.

Kinetic and sequence-structure-function analysis of known LinA variants with different hexachlorocyclohexane isomers.

Directory of Open Access Journals (Sweden)

Pooja Sharma

Full Text Available BACKGROUND: Here we report specific activities of all seven naturally occurring LinA variants towards three different isomers, α, γ and δ, of a priority persistent pollutant, hexachlorocyclohexane (HCH. Sequence-structure-function differences contributing to the differences in their stereospecificity for α-, γ-, and δ-HCH and enantiospecificity for (+- and (--α -HCH are also discussed. METHODOLOGY/PRINCIPAL FINDINGS: Enzyme kinetic studies were performed with purified LinA variants. Models of LinA2(B90A A110T, A111C, A110T/A111C and LinA1(B90A were constructed using the FoldX computer algorithm. Turnover rates (min(-1 showed that the LinAs exhibited differential substrate affinity amongst the four HCH isomers tested. α-HCH was found to be the most preferred substrate by all LinA's, followed by the γ and then δ isomer. CONCLUSIONS/SIGNIFICANCE: The kinetic observations suggest that LinA-γ1-7 is the best variant for developing an enzyme-based bioremediation technology for HCH. The majority of the sequence variation in the various linA genes that have been isolated is not neutral, but alters the enantio- and stereoselectivity of the encoded proteins.

Mary and femininity: A psychological critique.

Science.gov (United States)

Harrington, P A

1984-09-01

This essay uses Freud to interpret the symbolism and theology of Mary in modern Catholicism. In her role as the mother of believers, Mary functions to place the Christian in the position of a child who receives illusory gratification from the mother. In her role as model for Christians to emulate, Mary functions to place the Christian in the position of receptivity and dependence which Freud associated with femininity. Reinterpreting Freud from a feminist perspective, I suggest that the kind of femininity Mary represents serves to perpetuate patriachal social structures and to inhibit full psychological maturity.

Lin4Neuro: a customized Linux distribution ready for neuroimaging analysis.

Science.gov (United States)

Nemoto, Kiyotaka; Dan, Ippeita; Rorden, Christopher; Ohnishi, Takashi; Tsuzuki, Daisuke; Okamoto, Masako; Yamashita, Fumio; Asada, Takashi

2011-01-25

A variety of neuroimaging software packages have been released from various laboratories worldwide, and many researchers use these packages in combination. Though most of these software packages are freely available, some people find them difficult to install and configure because they are mostly based on UNIX-like operating systems. We developed a live USB-bootable Linux package named "Lin4Neuro." This system includes popular neuroimaging analysis tools. The user interface is customized so that even Windows users can use it intuitively. The boot time of this system was only around 40 seconds. We performed a benchmark test of inhomogeneity correction on 10 subjects of three-dimensional T1-weighted MRI scans. The processing speed of USB-booted Lin4Neuro was as fast as that of the package installed on the hard disk drive. We also installed Lin4Neuro on a virtualization software package that emulates the Linux environment on a Windows-based operation system. Although the processing speed was slower than that under other conditions, it remained comparable. With Lin4Neuro in one's hand, one can access neuroimaging software packages easily, and immediately focus on analyzing data. Lin4Neuro can be a good primer for beginners of neuroimaging analysis or students who are interested in neuroimaging analysis. It also provides a practical means of sharing analysis environments across sites.

Lin28 Mediates Cancer Chemotherapy Resistance via Regulation of miRNA Signaling.

Science.gov (United States)

Xu, Chaoyang; Xie, Shuduo; Song, Chunjiao; Huang, Liming; Jiang, Zhinong

2014-06-01

Chemotherapy resistance is one of the major obstacles limiting the success of cancer drug treatment. Among the mechanisms of resistance to chemotherapy treatment, there are those closely related to P-Glycoprotein, multidrug resistance-related protein, glutathione S-transferase pi and topoisomerase-II. Lin28 is a highly conserved RNA-binding protein, it consists of a cold shock domain and retroviral-type (CCHC) zinc finger motifs. In previous preclinical and clinical studies, positive Lin28 expression in cancer cells was correlated with decreased sensitivity to chemotherapy. And Lin28 could mediate cancer chemotherapy resistance via regulation of miR107 and Let-7 MiRNA. This article reviews current knowledge on predictive value of Lin28 in response to chemotherapy. Better understanding of its role may facilitate patient's selection of therapeutic regimen and lead to optimal clinical outcome.

Lin28b stimulates the reprogramming of rat Müller glia to retinal progenitors

Energy Technology Data Exchange (ETDEWEB)

Zhao, Chen; Tao, Zui; Xue, Langyue; Zeng, Yuxiao [Southwest Hospital/Southwest Eye Hospital, Third Military Medical University, Chongqing 400038 (China); Key Lab of Visual Damage and Regeneration & Restoration of Chongqing, Chongqing 400038 (China); Wang, Yi, E-mail: wangyieye@aliyun.com [Southwest Hospital/Southwest Eye Hospital, Third Military Medical University, Chongqing 400038 (China); Key Lab of Visual Damage and Regeneration & Restoration of Chongqing, Chongqing 400038 (China); Xu, Haiwei, E-mail: haiweixu2001@163.com [Southwest Hospital/Southwest Eye Hospital, Third Military Medical University, Chongqing 400038 (China); Key Lab of Visual Damage and Regeneration & Restoration of Chongqing, Chongqing 400038 (China); Yin, Zheng Qin, E-mail: qinzyin@aliyun.com [Southwest Hospital/Southwest Eye Hospital, Third Military Medical University, Chongqing 400038 (China); Key Lab of Visual Damage and Regeneration & Restoration of Chongqing, Chongqing 400038 (China)

2017-03-01

In lower-order vertebrates, Müller glia exhibit characteristics of retinal progenitor cells, while in higher vertebrates, such as mammals, the regenerative capacity of Müller glia is limited. Recently, we reported that Lin28b promoted the trans-differentiation of Müller cells to rod photoreceptor and bipolar cells in the retina of retinitis pigmentosa rat model, whereas it is unclear whether Lin28b can stimulate the reprogramming of Müller glia in vitro for transplantation into a damaged retina. In the present study, Long-Evens rat Müller glia were infected with Adeno-Lin28b or Adeno-GFP. Over-expression of Lin28b in isolated rat Müller glia resulted in the suppression of GFAP expression, enhancement of cell proliferation and a significant increase of the expression of retinal progenitor markers 5 days after infection. Moreover, Lin28b caused a significant reduction of the Let-7 family of microRNAs. Following sub-retinal space transplantation, Müller glia-derived retinal progenitors improved b-wave amplification of 30d Royal College of Surgeons retinitis pigmentosa model (RCS-P+) rats, as detected by electroretinography (ERG) recordings. Taken together, these data suggest that the up-regulation of Lin28b expression facilitated the reprogramming of Müller cells toward characteristics of retinal progenitors. - Highlights: • Lin28b reprograms Müller glia to retinal progenitors. • Let-7 micrRNAs are suppressed by Lin28b. • Transplantation of reprogrammed Müller glia restores retinal function.

Lin28b stimulates the reprogramming of rat Müller glia to retinal progenitors

International Nuclear Information System (INIS)

Zhao, Chen; Tao, Zui; Xue, Langyue; Zeng, Yuxiao; Wang, Yi; Xu, Haiwei; Yin, Zheng Qin

2017-01-01

In lower-order vertebrates, Müller glia exhibit characteristics of retinal progenitor cells, while in higher vertebrates, such as mammals, the regenerative capacity of Müller glia is limited. Recently, we reported that Lin28b promoted the trans-differentiation of Müller cells to rod photoreceptor and bipolar cells in the retina of retinitis pigmentosa rat model, whereas it is unclear whether Lin28b can stimulate the reprogramming of Müller glia in vitro for transplantation into a damaged retina. In the present study, Long-Evens rat Müller glia were infected with Adeno-Lin28b or Adeno-GFP. Over-expression of Lin28b in isolated rat Müller glia resulted in the suppression of GFAP expression, enhancement of cell proliferation and a significant increase of the expression of retinal progenitor markers 5 days after infection. Moreover, Lin28b caused a significant reduction of the Let-7 family of microRNAs. Following sub-retinal space transplantation, Müller glia-derived retinal progenitors improved b-wave amplification of 30d Royal College of Surgeons retinitis pigmentosa model (RCS-P+) rats, as detected by electroretinography (ERG) recordings. Taken together, these data suggest that the up-regulation of Lin28b expression facilitated the reprogramming of Müller cells toward characteristics of retinal progenitors. - Highlights: • Lin28b reprograms Müller glia to retinal progenitors. • Let-7 micrRNAs are suppressed by Lin28b. • Transplantation of reprogrammed Müller glia restores retinal function.

The lessons learned from Andra's Experiences on the Leachate Collection System of the Surface Disposal Facility

International Nuclear Information System (INIS)

Chang, Keunpack; Na, Hanjeong; Lee, Joonho; Lee, Dongjae

2014-01-01

This paper is based on the lessons learned from Andra's experiences especially on the drainage system which are given in the references. This paper also presents key items which need to be looked into for the local design which might be adopted at the second phase of LILW disposal facility at Wolsong. It is widely known that Andra has demonstrated that low and intermediate level of waste can be managed in a safe and efficient manner and disposed of surface level of ground. This paper has reviewed upgraded. EBSs evolved by Andra's many years of experiences, especially the measures to deal with drainage system which is available information online published to the public. Andra's Centre de I'Aube has been used as a reference model for the surface disposal of radioactive waste by many countries worldwide. But, the detail design of this type of facility needs to be improved and developed suitably for local characteristics taking into account the radioactive waste properties, local site environment and regulatory requirements in each country. The main design scenario to handle radioactive material in surface or near-surface radioactive nuclides are leached from waste by dissolving into rainwater passed through the disposal cover and concrete slab, and the infiltrated rainwater with radioactive nuclides flows to the aquifer through the concrete slab, and the infiltrated rainwater with radioactive nuclides flows to the aquifer through the concrete mat and the vadose zone, finally they are reached east sea through the aquifer or fault zone according to the hydro-geological characteristics of the site. The design concept to tackle this scenario and to deal with infiltrated and rain water in the surface disposal facility is described herein

Importance of the pluripotency factor LIN28 in the mammalian nucleolus during early embryonic development.

Science.gov (United States)

Vogt, Edgar J; Meglicki, Maciej; Hartung, Kristina Ilka; Borsuk, Ewa; Behr, Rüdiger

2012-12-01

The maternal nucleolus is required for proper activation of the embryonic genome (EGA) and early embryonic development. Nucleologenesis is characterized by the transformation of a nucleolar precursor body (NPB) to a mature nucleolus during preimplantation development. However, the function of NPBs and the involved molecular factors are unknown. We uncover a novel role for the pluripotency factor LIN28, the biological significance of which was previously demonstrated in the reprogramming of human somatic cells to induced pluripotent stem (iPS) cells. Here, we show that LIN28 accumulates at the NPB and the mature nucleolus in mouse preimplantation embryos and embryonic stem cells (ESCs), where it colocalizes with the nucleolar marker B23 (nucleophosmin 1). LIN28 has nucleolar localization in non-human primate (NHP) preimplantation embryos, but is cytoplasmic in NHP ESCs. Lin28 transcripts show a striking decline before mouse EGA, whereas LIN28 protein localizes to NPBs at the time of EGA. Following knockdown with a Lin28 morpholino, the majority of embryos arrest between the 2- and 4-cell stages and never develop to morula or blastocyst. Lin28 morpholino-injected embryos arrested at the 2-cell stage were not enriched with nucleophosmin at presumptive NPB sites, indicating that functional NPBs were not assembled. Based on these results, we propose that LIN28 is an essential factor of nucleologenesis during early embryonic development.

LIN28 phosphorylation by MAPK/ERK couples signaling to the post-transcriptional control of pluripotency

Science.gov (United States)

Tsanov, Kaloyan M.; Pearson, Daniel S.; Wu, Zhaoting; Han, Areum; Triboulet, Robinson; Seligson, Marc T.; Powers, John T.; Osborne, Jihan K.; Kane, Susan; Gygi, Steven P.; Gregory, Richard I.; Daley, George Q.

2016-01-01

Signaling and post-transcriptional gene control are both critical for the regulation of pluripotency1,2, yet how they are integrated to influence cell identity remains poorly understood. LIN28 (also known as LIN28A), a highly conserved RNA-binding protein (RBP), has emerged as a central post-transcriptional regulator of cell fate through blockade of let-7 microRNA (miRNA) biogenesis and direct modulation of mRNA translation3. Here we show that LIN28 is phosphorylated by MAPK/ERK in pluripotent stem cells (PSCs), which increases its levels via post-translational stabilization. LIN28 phosphorylation had little impact on let-7 but enhanced LIN28’s effect on its direct mRNA targets, revealing a mechanism that uncouples LIN28’s let-7-dependent and independent activities. We have linked this mechanism to the induction of pluripotency by somatic cell reprogramming and the transition from naïve to primed pluripotency. Collectively, our findings indicate that MAPK/ERK directly impacts LIN28, defining an axis that connects signaling, post-transcriptional gene control, and cell fate regulation. PMID:27992407

Investigation on the anisotropic mechanical behaviour of the Callovo-Oxfordian clay rock within the framework of ANDRA/GRS cooperation programme. Final report

Energy Technology Data Exchange (ETDEWEB)

Zhang, Chun-Liang [Gesellschaft fuer Anlagen- und Reaktorsicherheit mbH (GRS), Koeln (Germany); Armand, Gilles; Conil, Nathalie [French Agence Nationale Pour la Gestion de Dechets Radioactifs (ANDRA), Chatenay-Malabry (France)

2015-01-15

An underground repository for disposal of radioactive waste is planned to be constructed in the sedimentary Callovo-Oxfordian argillaceous formation (COX) in France /AND 05/. The clay rock exhibits inherent anisotropy with bedding structure, which leads to directional dependences of the rock properties (e.g. mineralogical, physical, mechanical, hydraulic, thermal, etc.) with respect to the bedding planes. For the design of the repository and the assessment of its safety during the operation and post-closure phases it is necessary to characterise and predict the anisotropic properties and processes in the host rock, particularly in the excavation damaged zone (EDZ) near the openings. Within the framework of the bilateral cooperation agreement between the French National Radioactive Waste Management Agency (ANDRA) and the German Federal Ministry of Economics and Technology (BMWi), concerning the research activities in the Meuse/Haute-Marne Underground Research Laboratory (MHM-URL), a joint research programme was initiated by ANDRA and GRS in 2013 to investigate mechanical anisotropy of the COX clay rock for the purpose of precise characterization, better understanding and reliable prediction of the development of EDZ around the repository. This programme was funded by ANDRA under contract number 059844 and performed by GRS during the time period of November 2013 to December 2014. GRS gratefully acknowledges the financial support from and the fruitful cooperation with ANDRA.

Scientific days, ANDRA 1999. Summary of conferences and poster communications; Journees scientifiques, ANDRA 1999. Resume des conferences et des communications par affiches

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-12-01

This document summarizes the content of the 1999 scientific conference days organized by the French national agency of radioactive wastes (ANDRA). The content comprises: the opening session (2 talks), 4 general conferences dealing with important questions relative to feasibility studies of waste disposal. These conferencesare complementary to the four technical sessions developed thereafter (hydro-geochemistry and solutes transport in the geosphere; storage materials; geomechanics; research programs in underground laboratories). A large part of the conference was devoted to poster sessions on the following topics: geology, hydro-geochemistry and hydrogeology, geomechanics, storage materials (metals and clay materials), behaviour of radionuclides (geosphere, biosphere), and numerical analysis applied to hydro-geochemistry and transport. (J.S.)

Marie Curie: scientific entrepreneur

International Nuclear Information System (INIS)

Boudia, S.

1998-01-01

Marie Curie is best known for her discovery of radium one hundred years ago this month, but she also worked closely with industry in developing methods to make and monitor radioactive material, as Soraya Boudia explains. One hundred years ago this month, on 28 December 1898, Pierre Curie, Marie Sklodowska-Curie and Gustave Bemont published a paper in Comptes-rendus - the journal of the French Academy of Sciences. In the paper they announced that they had discovered a new element with astonishing properties: radium. But for one of the authors, Marie Curie, the paper was more than just the result of outstanding work: it showed that a woman could succeed in what was then very much a male-dominated scientific world. Having arrived in Paris from Poland in 1891, Marie Curie became the first woman in France to obtain a PhD in physics, the first woman to win a Nobel prize and the first woman to teach at the Sorbonne. She also helped to found a new scientific discipline: the study of radioactivity. She became an icon and a role-model for other women to follow, someone who succeeded - despite many difficulties - in imposing herself on the world of science. Although Curie's life story is a familiar and well documented one, there is one side to her that is less well known: her interaction with industry. As well as training many nuclear physicists and radiochemists in her laboratory, she also became a scientific pioneer in industrial collaboration. In this article the author describes this side of Marie Curie. (UK)

Jean-Marie Dufour 1937-2007

CERN Multimedia

2007-01-01

Jean-Marie Dufour, who was head of the CERN Legal Service from 1974 until his retirement in 2001, passed away on 8 July. Following his arrival at CERN in 1966 during the crucial phase of expansion of the Laboratory’s site, Jean-Marie Dufour ensured that CERN’s rules were applied while taking part in essential stages of the Organization’s development. With his fine mind and erudition, Jean-Marie Dufour, a staunch European devoted to the CERN cause, has left his mark on the Legal Service. The Service will publish a tribute to him in a forthcoming issue of the Bulletin.

A Dynamic Attitude Measurement System Based on LINS

Directory of Open Access Journals (Sweden)

Hanzhou Li

2014-08-01

Full Text Available A dynamic attitude measurement system (DAMS is developed based on a laser inertial navigation system (LINS. Three factors of the dynamic attitude measurement error using LINS are analyzed: dynamic error, time synchronization and phase lag. An optimal coning errors compensation algorithm is used to reduce coning errors, and two-axis wobbling verification experiments are presented in the paper. The tests indicate that the attitude accuracy is improved 2-fold by the algorithm. In order to decrease coning errors further, the attitude updating frequency is improved from 200 Hz to 2000 Hz. At the same time, a novel finite impulse response (FIR filter with three notches is designed to filter the dither frequency of the ring laser gyro (RLG. The comparison tests suggest that the new filter is five times more effective than the old one. The paper indicates that phase-frequency characteristics of FIR filter and first-order holder of navigation computer constitute the main sources of phase lag in LINS. A formula to calculate the LINS attitude phase lag is introduced in the paper. The expressions of dynamic attitude errors induced by phase lag are derived. The paper proposes a novel synchronization mechanism that is able to simultaneously solve the problems of dynamic test synchronization and phase compensation. A single-axis turntable and a laser interferometer are applied to verify the synchronization mechanism. The experiments results show that the theoretically calculated values of phase lag and attitude error induced by phase lag can both match perfectly with testing data. The block diagram of DAMS and physical photos are presented in the paper. The final experiments demonstrate that the real-time attitude measurement accuracy of DAMS can reach up to 20″ (1σ and the synchronization error is less than 0.2 ms on the condition of three axes wobbling for 10 min.

A Dynamic Attitude Measurement System Based on LINS

Science.gov (United States)

Li, Hanzhou; Pan, Quan; Wang, Xiaoxu; Zhang, Juanni; Li, Jiang; Jiang, Xiangjun

2014-01-01

A dynamic attitude measurement system (DAMS) is developed based on a laser inertial navigation system (LINS). Three factors of the dynamic attitude measurement error using LINS are analyzed: dynamic error, time synchronization and phase lag. An optimal coning errors compensation algorithm is used to reduce coning errors, and two-axis wobbling verification experiments are presented in the paper. The tests indicate that the attitude accuracy is improved 2-fold by the algorithm. In order to decrease coning errors further, the attitude updating frequency is improved from 200 Hz to 2000 Hz. At the same time, a novel finite impulse response (FIR) filter with three notches is designed to filter the dither frequency of the ring laser gyro (RLG). The comparison tests suggest that the new filter is five times more effective than the old one. The paper indicates that phase-frequency characteristics of FIR filter and first-order holder of navigation computer constitute the main sources of phase lag in LINS. A formula to calculate the LINS attitude phase lag is introduced in the paper. The expressions of dynamic attitude errors induced by phase lag are derived. The paper proposes a novel synchronization mechanism that is able to simultaneously solve the problems of dynamic test synchronization and phase compensation. A single-axis turntable and a laser interferometer are applied to verify the synchronization mechanism. The experiments results show that the theoretically calculated values of phase lag and attitude error induced by phase lag can both match perfectly with testing data. The block diagram of DAMS and physical photos are presented in the paper. The final experiments demonstrate that the real-time attitude measurement accuracy of DAMS can reach up to 20″ (1σ) and the synchronization error is less than 0.2 ms on the condition of three axes wobbling for 10 min. PMID:25177802

Robotic Software Integration Using MARIE

Directory of Open Access Journals (Sweden)

Carle Côté

2006-03-01

Full Text Available This paper presents MARIE, a middleware framework oriented towards developing and integrating new and existing software for robotic systems. By using a generic communication framework, MARIE aims to create a flexible distributed component system that allows robotics developers to share software programs and algorithms, and design prototypes rapidly based on their own integration needs. The use of MARIE is illustrated with the design of a socially interactive autonomous mobile robot platform capable of map building, localization, navigation, tasks scheduling, sound source localization, tracking and separation, speech recognition and generation, visual tracking, message reading and graphical interaction using a touch screen interface.

Le nævus épidermique verruqueux inflammatoire linéaire ...

African Journals Online (AJOL)

Le nævus épidermique verruqueux inflammatoire linéaire (NEVIL) est une affection rare correspondant à des hyperplasies épidermiques bénignes qui se présentent cliniquement sous forme de lésions linéaires unilatérales hyperkératosiques. Une adolescente âgée de 16 ans, sans antécédents, présentait depuis la ...

107 Définition structurale des linéaments par traitement d'image ...

African Journals Online (AJOL)

Valued Packard Bell Customer

The Ngovayang massif represents a key domain in understanding the geodynamics of the northern border of the Congo craton in South Cameroon. Remote sensing works .... linéaments liés au socle rocheux et aux accidents tectoniques (Minyem, 1994 [2]). Ces linéaments sont repartis selon trois directions. - la direction ...

Mary Shelley: Teaching and Learning through "Frankenstein"

Science.gov (United States)

Girard, Theresa M.

2009-01-01

In the writing of "Frankenstein", Mary Shelley was able to change the course of women's learning, forever. Her life started from an elite standpoint as the child of Mary Wollstonecraft and William Godwin. As such, she was destined to grow to be a major influence in the world. Mary Shelley's formative years were spent with her father and his many…

"Mary Hartman, Mary Hartman": An Analysis of Satire as a Violation of Soap Opera Stereotypes.

Science.gov (United States)

Gaulard, Joan M.

The soap opera "Mary Hartman, Mary Hartman" presents an interesting new genre in television, as it defies the conventional standards and stereotypes associated with daytime drama. The central character is not a dependent victim but a survivor who indicates to her viewers the concept which advertisers and media management have of them. A…

"Mary Hartman, Mary Hartman"; A New Genre of Prosocial Programming, or Just Another Soap Opera?

Science.gov (United States)

Surlin, Stuart H.; Maloof, Mary C.

This paper discusses the wide appeal, and the effect on the viewing audience, of traditional television soap operas. It reports on a comparison of role interactions, topics discussed by the characters, and types of topics and problems presented on the television program "Mary Hartman, Mary Hartman" with those presented on two traditional…

LIN-32/Atonal Controls Oxygen Sensing Neuron Development in Caenorhabditis elegans

DEFF Research Database (Denmark)

Romanos, Teresa Rojo; Pladevall-Morera, David; Langebeck-Jensen, Kasper

2017-01-01

HLH) family of transcription factors has multiple functions in neurogenesis. Here, we identified the LIN-32/Atonal bHLH transcription factor as a key regulator of URXL/R oxygen-sensing neuron development in Caenorhabditis elegans. When LIN-32/Atonal expression is lost, the expression of URX specification......Development of complex nervous systems requires precisely controlled neurogenesis. The generation and specification of neurons occur through the transcriptional and post-Transcriptional control of complex regulatory networks. In vertebrates and invertebrates, the proneural basic-helix-loop-helix (b...... and terminal differentiation genes is abrogated. As such, lin-32 mutant animals are unable to respond to increases in environmental oxygen. The URX neurons are generated from a branch of the cell lineage that also produces the CEPDL/R and URADL/R neurons. We found development of these neurons is also defective...

Marie and Pierre Curie. Life in extremes; Marie and Pierre Curie. Leben in Extremen

Energy Technology Data Exchange (ETDEWEB)

Roethlein, Brigitte

2008-07-01

In Paris in 1894, two young physicists fall in love: Marie Sklodowska and Pierre Curie. They get married and make great contributions to science, research radioactivity and discover new chemical elements. The marriage of Marie and Pierre Curie is quite modern: They work together as equals, share their thoughts and pursue their plans together as partners. They share an absolute interest in science, a love of nature, and a sceptic attitude towards the sophisticated society of the Belle Epoque. They are together 24 hours a day with hardly ever any disagreement. Whenever one of them is ill - which is quite often because of the high level of radioactivity in their laboratory -, the other will nurse him or her. After only twelve years of mutual love, Pierre Curie dies. Marie raises their two daughters on her own and continues her research. In 1911, she will be the first scientist that ever gets a second Nobel Prize. (orig.) [German] Im Paris des Jahres 1894 verlieben sich zwei junge Physiker: Marie Sklodowska und Pierre Curie. Sie heiraten und leisten gemeinsam Grosses fuer die Wissenschaft, erforschen die Radioaktivitaet und entdecken neue chemische Elemente. Zusammen erhalten sie den Nobelpreis. Marie und Pierre Curie fuehren eine Ehe, die ihrer Zeit weit voraus ist: Sie arbeiten gleichberechtigt miteinander, teilen ihre Gedanken und verfolgen ihre Plaene gemeinsam. Beiden eigen ist die absolute wissenschaftliche Neugier, die Liebe zur Natur und die Skepsis gegenueber der mondaenen Gesellschaft der Belle Epoque. Fast jeden Tag sind sie rund um die Uhr zusammen, dabei gibt es selten Spannungen. Wenn einer von beiden gesundheitliche Probleme hat - und das haben sie wegen der radioaktiven Belastung im Labor oft - ist der andere fuer ihn da und pflegt ihn. Nach nur zwoelf gemeinsamen Jahren der Liebe und Arbeit stirbt Pierre Curie. Marie zieht ihre beiden Toechter alleine gross und fuehrt die Forschungen weiter. 1911 erhaelt sie als erster Mensch zum zweiten Mal den

HA Cells monitoring at the Underground Research Laboratory (URL) in the CMHM (Andra)

International Nuclear Information System (INIS)

Gay, Olivier; Allagnat, Dominique; Morel, Jacques; Armand, Gilles

2010-01-01

The experimental monitoring program of the HA (High Activity) cells was carried out at the Underground Research Laboratory (URL) in the Meuse Haute Marne department in France (CMHM Andra). Inspections made by video and photographs, section measurements and geo-referenced trajectories, in addition to measurements of convergence, temperature and hygrometry over time, allowed a better analysis of the behaviour of the HA cells after excavation, and subsequently over the long term. (authors)

Follow-up by the ANDRA to the Cigeo project after the public debate - Industrial centre of geological storage of radioactive wastes

International Nuclear Information System (INIS)

2014-05-01

In a first part, this report comments and discusses the evolutions of the Cigeo (industrial centre of geological storage of radioactive wastes) project after the public debate in terms of: integration of a pilot industrial phase to the installation start up, implementation of a regularly reviewed master plan for the storage exploitation, a planning arrangement, and commitment of civil society in the project. The next part briefly presents the different steps defined by the ANDRA to answer the demand for reversibility. The third part states ANDRA's commitments: to guarantee safety above all, to preserve and to develop the hosting territory, and to manage the costs

Regulation of C. elegans L4 cuticle collagen genes by the heterochronic protein LIN-29.

Science.gov (United States)

Abete-Luzi, Patricia; Eisenmann, David M

2018-05-01

The cuticle, the outer covering of the nematode C. elegans, is synthesized five times during the worm's life by the underlying hypodermis. Cuticle collagens, the major cuticle component, are encoded by a large family of col genes and, interestingly, many of these genes express predominantly at a single developmental stage. This temporal preference motivated us to investigate the mechanisms underlying col gene expression and here we focus on a subset of col genes expressed in the L4 stage. We identified minimal promoter regions of <300 bp for col-38, col-49, and col-63. In these regions, we predicted cis-regulatory sequences and evaluated their function in vivo via mutagenesis of a col-38p::yfp reporter. We used RNAi to study the requirement for candidate transcription regulators ELT-1 and ELT-3, LIN-29, and the LIN-29 co-factor MAB-10, and found LIN-29 to be necessary for the expression of four L4-specific genes (col-38, col-49, col-63, and col-138). Temporal misexpression of LIN-29 was also sufficient to activate these genes at a different developmental stage. The LIN-29 DNA-binding domain bound the col-38, col-49, and col-63 minimal promoters in vitro. For col-38 we showed that the LIN-29 sites necessary for reporter expression in vivo are also bound in vitro: this is the first identification of specific binding sites for LIN-29 necessary for in vivo target gene expression. © 2018 Wiley Periodicals, Inc.

The National Agency for the management of radioactive wastes (ANDRA). Specific report (articles L. 143-3 and R. 143-1 of the Code of financial courts). Years 2008 to 2013 (Update 2014) - December 2015

International Nuclear Information System (INIS)

2015-12-01

After a recall of ANDRA's missions, a statement outlines the good financial situation of the Agency for the considered period. The report first describes the ANDRA's operation, its governance, its operation in project-mode, organisation and relationship with public bodies and authorities. The second part describes and analyses the various components of its management: human resources management, the purchasing function, taxation. The third part comments ANDRA's accounts and budget: quality of accounts and financial audit, accounting and financial analysis. The last part addresses ANDRA's activities: long-winded projects for future storage sites, storage centres, management of wastes of small producers outside electronuclear activity, missions of public service. An opinion on management is finally provided

Marie Curie; Marie Curie

Energy Technology Data Exchange (ETDEWEB)

Trotereau, J.

2011-07-01

The legend has only retained from Marie Curie (1867-1934) the image of a hard and brilliant worker, pioneer in the radioactivity domain, and who awarded twice the Nobel Price. Behind the scientist, there is a women, Marya Salomea Sklodowska, the 'Polish', who was considered during some time as an 'alien', an 'atheistic intellectual', an 'emancipated women'. When she died alone in July 1934, after an exhausting life of labour, her funeral led to no official ceremony or speech. This small book summarizes the biography of the most famous female scientist in the world

Marie Underile pühendatakse konverents

Index Scriptorium Estoniae

2008-01-01

Tartus Eesti Kirjandusmuuseumis toimuvast Marie Underi 125. sünniaastapäevale pühendatud konverentsist ja näitusest "Kunsti Marie Underi kodust". Vt. ka Keel ja Kirjandus, nr. 4, 2008, lk. 317; Looming, nr. 4, 2008, lk. 635; Keel ja Kirjandus, nr. 7, lk. 570-572

Scientific days, ANDRA 1999. Summary of conferences and poster communications

International Nuclear Information System (INIS)

1999-12-01

This document summarizes the content of the 1999 scientific conference days organized by the French national agency of radioactive wastes (ANDRA). The content comprises: the opening session (2 talks), 4 general conferences dealing with important questions relative to feasibility studies of waste disposal. These conferences are complementary to the four technical sessions developed thereafter (hydro-geochemistry and solutes transport in the geosphere; storage materials; geomechanics; research programs in underground laboratories). A large part of the conference was devoted to poster sessions on the following topics: geology, hydro-geochemistry and hydrogeology, geomechanics, storage materials (metals and clay materials), behaviour of radionuclides (geosphere, biosphere), and numerical analysis applied to hydro-geochemistry and transport. (J.S.)

The Perennial Environment Observatory by A.N.D.R.A. (the French National Radioactive Waste Management Agency)

International Nuclear Information System (INIS)

Leclerc, E.

2010-01-01

The Perennial Environment Observatory [Observatoire Perenne de l'Environnement - OPE] is a unique approach and infrastructure developed and implemented by ANDRA, the French National Radioactive Waste Management Agency, as part of its overall project of deep geological disposal for radioactive waste. Its current mission is to assess the initial state of the rural (forest, pasture, open-field and aquatic) environment, prior to repository construction. This will be followed in 2017 (pending construction authorizations) and for a period exceeding a century, by monitoring of any impact the repository may have on the environment. In addition to serving its own industrial purpose of environmental monitoring, ANDRA also opens the OPE approach, infrastructure and acquired knowledge (database...) to the scientific community to support further research on long term evolution of the environment subjected to natural and anthropogenic stresses, and to contribute to a better understanding of the interaction between the various compartments of the environment. (author)

Mary Shelley as editor of Percy Shelley

OpenAIRE

Allen, Richard

2001-01-01

This chapter explores Mary Shelley's work as the founding editor of Percy Shelley's poetry. It sets out the circumstances of Mary Shelley's life after the death of Percy Shelley, her financial dependence on Percy Shelley's father, and the restrictions placed on publication by Shelley's father. It then sets out the strategies Mary Shelley used to construct a biography of Percy Shelley from the poem, thus establishing a Romantic biography of Percy Shelley which has endured into the 20th century,

Mari e-raamatukogu / Tatjana Verina ; vene keelest tõlkinud Ene Riet

Index Scriptorium Estoniae

Verina, Tatjana

2011-01-01

Mari e-raamatukogu loomise aluseks on Mari-Eli Vabariigi etnokultuuriliste ja rahvusvaheliste suhete arendamise projekt, hetkel on elektroonilises raamatukogus 52 täistekstilist teavikut Tšavaini nimelise Mari Rahvusraamatukogu haruldaste raamatute kogust

Remembering Mary Tyler Moore | MedlinPlus Magazine

Science.gov (United States)

... Remembering Mary Tyler Moore Follow us NIH MedlinePlus Magazine Remembers Mary Tyler Moore A little more than ... helped launch the first issue of NIH MedlinePlus magazine on Capitol Hill. The award-winning actress and ...

ANDRA - National Radioactive Waste Management Agency. Activity and sustainable development report 2010 - a year with Andra. Management report and financial statements 2010 - Managing today to prepare for tomorrow

International Nuclear Information System (INIS)

2011-01-01

Created in 1979 within the CEA, the National Radioactive Waste Management Agency (ANDRA) was established by the December 1991 Waste Act as a public body in charge of the long-term management of all radioactive waste, under the supervision of the Ministry of Ecology, Energy, Sustainable Development and the Sea (formerly the Ministry of Industry and the Ministry of Environment), and the Ministry of Research. Its 3 basic missions were extended and their funding secured through the 2006 Planning Act: - a R and D mission to propose safe long-term solution for radioactive waste without current disposal system; this mission includes long-term storage, since the 2006 Planning Act, in order to propose interim solutions while final ones are being studied; - an industrial mission concerning, on one hand, waste acceptance criteria and control and, on the other hand, siting, construction, operation, closure and monitoring of repositories. This mission includes as well a public service mission in terms of i) collection of waste of the 'small-scale nuclear activities' producers or owners (including the so-called 'household' radioactive waste, i.e. waste owned by private individuals) and ii) clean-up and rehabilitation of orphan polluted sites; - an information mission, notably through the regular publication of the National Inventory of radioactive materials and waste. This mission includes as well an active policy of dialogue with stakeholders both at national and local level. This document is the activity and Sustainable Development Report, with the management and financial statements report, of the Andra for the year 2010

Adaptation of Russian Christian Names into the Mari Language

Directory of Open Access Journals (Sweden)

Alexander L. Pustyakov

2017-11-01

Full Text Available This article analyses the phonetic and morphological adaptation of Christian personal names in the Mari language. The work examines personal names recorded in different regions among the Mari. The composition of the presented data is not exhaustive; it does, however, allow one to observe some general patterns of the adaptation process. The main part of the article is preceded by a brief overview of the Christianization of the Mari region and the contacts between the Mari and the Russian-speaking population; the features of the local dialects of the Russian language are briefly stated. The Mari language incorporated a significant number of Russian names. The source of loans included, besides the standard church name forms, also the numerous varieties found in the Russian dialects. As part of the study, phonetic, structural changes of Christian names in the Mari language are revealed and the reasons for the majority of these transformations are identified. The author also pays attention to the intermediary role of the neighbouring Turkic languages in the penetration of Russian names into the Mari language. Changes in borrowed names were induced by internal Mari linguistic rules, as well as dialectal features of the local Russian dialects. The identification of systematic phonetic and structural transformations helps to determine the origin of obscure anthroponyms.

Clinical application of Lin's biopsy grasper for intrauterine targeted biopsy and polypectomy during office hysteroscopy.

Science.gov (United States)

Cheng, Hsin-Yi; Lin, Bao-Liang; Tseng, Jen-Yu; Ueno, Kazunori; Nakada, Sakura

2018-06-01

Hysteroscopy has widely been used for diagnosis of the uterine cavity; however, target biopsy has often been difficult in part to the inherent limitations of ancillary instruments. Lin's biopsy grasper was specifically designed to work in conjunction with a flexible hysteroscope to obtain intrauterine biopsy under transabdominal sonography. Herein, we share our clinical experience in the management of endometrial abnormalities with the use of Lin's biopsy grasper during office-based hysteroscopy. From February 2006 to November 2016, the use of Lin's biopsy grasper for tissue biopsy was attempted on 126 cases. We retrospectively recorded and analyzed the patients' preoperative characteristics and biopsy outcomes to demonstrate the feasibility and efficacy of Lin's biopsy grasper. Out of the one hundred and twenty-six enrolled patients, satisfactory targeted biopsies were achieved; including high diagnostic rate (92.1%, with 116 cases confirmed histologically) and adequate tissue retrieval (77.8%, with 98 cases obtaining optimal specimen volume). All patients tolerated the procedure without analgesics or anesthesia. Diagnostic flexible hysteroscopy combined with the use of Lin's biopsy grasper has proven to be an effective tool for intrauterine evaluation and obtaining tissue sample. Copyright © 2018. Published by Elsevier B.V.

Lady Mary Sidney Herbert a Lady Mary Wroth: labutí píseň a imaginativní svět jako součást rodinného odkazu (Lady Mary Sidney Herbert and Lady Mary Wroth: a Swan song and Fictional World as a part of Sidneyan legacy

Directory of Open Access Journals (Sweden)

Martina Kastnerová

2017-03-01

Full Text Available The study intends to clarify the process of forming of Sidneyan literary cult as a part of (Sidneyʼs family legacy based on the the literary activities of Sidneyʼs sister Lady Mary Sidney Herbert, countess of Pembroke, and his niece Lady Mary Wroth, daughter of his younger brother Robert. Mary Sidney Herbert throughout her literary career sings a swan song of her brother, Mary Wroth creates an imaginative world of free love choice and happy endings and her literary career is based on the well-established cult of Sidneyʼs name.

régression linéaire multiple

African Journals Online (AJOL)

Mots clés: Alcools et phénols – Représentation numérique de la structure chimique – Facteur acentrique – Régression linéaire multiple – Modèle RSP hybride. English Title: Structure / acentric factor relationship of alcohols and phenols: genetic algorithm – multiple linear regression approach. English Abstract. The acentric ...

Association of Lin-28A rs3811464 Variant with Susceptibility to Type 2 Diabetes

Directory of Open Access Journals (Sweden)

Mona Khodabandeh

2017-11-01

Full Text Available Introduction: It has been suggested that Lin-28A and the let-7 microRNA family (Lin-28/let-7 axis play a critical role in the control of glucose metabolism, insulin sensitivity and resistance to diabetes. Aim: This case-control study aimed at evaluating the association between Lin-28 rs3811464 polymorphism and the susceptibility to Type 2 Diabetes (T2D in a sample of Iranian population. Materials and Methods: This study involved 172 T2D patients and 160 non-diabetic age and gender-matched controls. Lin 28A rs3811464 genotypes were determined by Polymerase Chain Reaction–Restriction Fragment Length Polymorphism (PCR-RFLP technique. Results: The results showed that the frequency of the AA genotype was significantly higher in control subjects than in diabetic patients (13.12% vs. 4.65%. In addition, binary logistic regression analysis revealed that rs3811464-AA genotype was significantly associated to T2D after adjustment for BMI, age and lipid profiles. Indeed, subjects with AA genotype were less likely to develop T2D than GG and AG subjects (OR of 0.26, 95% CI 0.10-0.66, p=0.005. Conclusion: The findings of our study suggest that the Lin 28A rs3811464 is associated with type 2 diabetes susceptibility and subjects with AA genotypes were less likely to develop T2D diabetes.

ANDRA - National Radioactive Waste Management Agency. Activity report 2015. Financial report 2015

International Nuclear Information System (INIS)

2016-01-01

Created in 1979 within the CEA, the National Radioactive Waste Management Agency (ANDRA) was established by the December 1991 Waste Act as a public body in charge of the long-term management of all radioactive waste, under the supervision of the Ministry of Ecology, Energy, Sustainable Development and the Sea (formerly the Ministry of Industry and the Ministry of Environment), and the Ministry of Research. Its 3 basic missions were extended and their funding secured through the 2006 Planning Act: - a R and D mission to propose safe long-term solution for radioactive waste without current disposal system; this mission includes long-term storage, since the 2006 Planning Act, in order to propose interim solutions while final ones are being studied; - an industrial mission concerning, on one hand, waste acceptance criteria and control and, on the other hand, siting, construction, operation, closure and monitoring of repositories. This mission includes as well a public service mission in terms of i) collection of waste of the 'small-scale nuclear activities' producers or owners (including the so-called 'household' radioactive waste, i.e. waste owned by private individuals) and ii) clean-up and rehabilitation of orphan polluted sites; - an information mission, notably through the regular publication of the National Inventory of radioactive materials and waste. This mission includes as well an active policy of dialogue with stakeholders both at national and local level. This document is the activity and financial report of the Andra for the year 2015

ANDRA - National Radioactive Waste Management Agency. Activity report 2016. Financial report 2016

International Nuclear Information System (INIS)

2017-01-01

Created in 1979 within the CEA, the National Radioactive Waste Management Agency (ANDRA) was established by the December 1991 Waste Act as a public body in charge of the long-term management of all radioactive waste, under the supervision of the Ministry of Ecology, Energy, Sustainable Development and the Sea (formerly the Ministry of Industry and the Ministry of Environment), and the Ministry of Research. Its 3 basic missions were extended and their funding secured through the 2006 Planning Act: - a R and D mission to propose safe long-term solution for radioactive waste without current disposal system; this mission includes long-term storage, since the 2006 Planning Act, in order to propose interim solutions while final ones are being studied; - an industrial mission concerning, on one hand, waste acceptance criteria and control and, on the other hand, siting, construction, operation, closure and monitoring of repositories. This mission includes as well a public service mission in terms of i) collection of waste of the 'small-scale nuclear activities' producers or owners (including the so-called 'household' radioactive waste, i.e. waste owned by private individuals) and ii) clean-up and rehabilitation of orphan polluted sites; - an information mission, notably through the regular publication of the National Inventory of radioactive materials and waste. This mission includes as well an active policy of dialogue with stakeholders both at national and local level. This document is the activity and financial report of the Andra for the year 2016

Metabolomics of hexachlorocyclohexane (HCH) transformation: ratio of LinA to LinB determines metabolic fate of HCH isomers.

Science.gov (United States)

Geueke, Birgit; Garg, Nidhi; Ghosh, Sneha; Fleischmann, Thomas; Holliger, Christof; Lal, Rup; Kohler, Hans-Peter E

2013-04-01

Although the production and use of technical hexachlorocyclohexane (HCH) and lindane (the purified insecticidal isomer γ-HCH) are prohibited in most countries, residual concentrations still constitute an immense environmental burden. Many studies describe the mineralization of γ-HCH by bacterial strains under aerobic conditions. However, the metabolic fate of the other HCH isomers is not well known. In this study, we investigated the transformation of α-, β-, γ-, δ-, ε-HCH, and a heptachlorocyclohexane isomer in the presence of varying ratios of the two enzymes that initiate γ-HCH degradation, a dehydrochlorinase (LinA) and a haloalkane dehalogenase (LinB). Each substrate yielded a unique metabolic profile that was strongly dependent on the enzyme ratio. Comparison of these results to those of in vivo experiments with different bacterial isolates showed that HCH transformation in the tested strains was highly optimized towards productive metabolism of γ-HCH and that under these conditions other HCH-isomers were metabolized to mixtures of dehydrochlorinated and hydroxylated side-products. In view of these results, bioremediation efforts need very careful planning and toxicities of accumulating metabolites need to be evaluated. © 2012 Society for Applied Microbiology and Blackwell Publishing Ltd.

Moved by Mary: the power of pilgrimage in the modern world

NARCIS (Netherlands)

Hermkens, A.K.; Jansen, W.H.M.; Notermans, C.D.

2009-01-01

The Virgin Mary continues to attract devotees to her images and shrines. In Moved by Mary, anthropologists, geographers and historians explore how people and groups around the world identify and join with Mary in their struggle against social injustice, and how others mobilize Mary to impose ideas

Jean-Marie Dufour 1937-2007

CERN Multimedia

2007-01-01

Picture taken by Rudiger Voss in the Legal Service LibraryJean-Marie Dufour, CERN Legal Advisor from 1974 until his retirement in 2001, passed away on 8 July. For us, his colleagues in the Legal Service, Jean-Marie was a tutor and a reference, who passed on to us his passion for the practice of law in an intergovernmental organisation. As a boss, his abiding managerial quality was his unstinting loyalty to his collaborators. Jean-Marie joined CERN in 1966 and for the next 35 years was to be the guardian of the Laboratory’s rules. This was his view of the Organization: "...I have discovered [at CERN] a fascinating universe driven by two forces: science and Europe; a world of physicists and engineers who, encouraged by the States of Europe, run a remarkable Laboratory, where Europeans have achieved reconciliation and restored the grand tradition of European physics, attracting physicists from around the world; a Laboratory that transcends not only the fro...

Biodegradation of γ-hexachlorocyclohexane by transgenic hairy root cultures of Cucurbita moschata that accumulate recombinant bacterial LinA.

Science.gov (United States)

Nanasato, Yoshihiko; Namiki, Sayuri; Oshima, Masao; Moriuchi, Ryota; Konagaya, Ken-Ichi; Seike, Nobuyasu; Otani, Takashi; Nagata, Yuji; Tsuda, Masataka; Tabei, Yutaka

2016-09-01

γ-HCH was successfully degraded using LinA-expressed transgenic hairy root cultures of Cucurbita moschata . Fusing an endoplasmic reticulum-targeting signal peptide to LinA was essential for stable accumulation in the hairy roots. The pesticide γ-hexachlorocyclohexane (γ-HCH) is a persistent organic pollutant (POP) that raises public health and environmental pollution concerns worldwide. Although several isolates of γ-HCH-degrading bacteria are available, inoculating them directly into γ-HCH-contaminated soil is ineffective because of the bacterial survival rate. Cucurbita species incorporate significant amounts of POPs from soils compared with other plant species. Here, we describe a novel bioremediation strategy that combines the bacterial degradation of γ-HCH and the efficient uptake of γ-HCH by Cucurbita species. We produced transgenic hairy root cultures of Cucurbita moschata that expressed recombinant bacterial linA, isolated from the bacterium Sphingobium japonicum UT26. The LinA protein was accumulated stably in the hairy root cultures by fusing an endoplasmic reticulum (ER)-targeting signal peptide to LinA. Then, we demonstrated that the cultures degraded more than 90 % of γ-HCH (1 ppm) overnight and produced the γ-HCH metabolite 1,2,4-trichlorobenzene, indicating that LinA degraded γ-HCH. These results indicate that the gene linA has high potential for phytoremediation of environmental γ-HCH.

LINS Curve in Romanian Economy

Directory of Open Access Journals (Sweden)

Emilian Dobrescu

2016-02-01

Full Text Available The paper presents theoretical considerations and empirical evidence to test the validity of the Laffer in Narrower Sense (LINS curve as a parabola with a maximum. Attention is focused on the so-called legal-effective tax gap (letg. The econometric application is based on statistical data (1990-2013 for Romania as an emerging European economy. Three cointegrating regressions (fully modified least squares, canonical cointegrating regression and dynamic least squares and three algorithms, which are based on instrumental variables (two-stage least squares, generalized method of moments, and limited information maximum likelihood, are involved.

Mary Anne Chambers | IDRC - International Development Research ...

International Development Research Centre (IDRC) Digital Library (Canada)

A former Member of Provincial Parliament, Mary Anne served as Minister of Training, Colleges and Universities, and Minister of Children and Youth Services in the Government of Ontario. She is also a former senior vice-president of Scotiabank. A graduate of the University of Toronto, Mary Anne has received honorary ...

MaRIE Undulator & XFEL Systems

Energy Technology Data Exchange (ETDEWEB)

Nguyen, Dinh Cong [Los Alamos National Laboratory; Marksteiner, Quinn R. [Los Alamos National Laboratory; Anisimov, Petr Mikhaylovich [Los Alamos National Laboratory; Buechler, Cynthia Eileen [Los Alamos National Laboratory

2015-03-23

The 22 slides in this presentation treat the subject under the following headings: MaRIE XFEL Performance Parameters, Input Electron Beam Parameters, Undulator Design, Genesis Simulations, Risks, and Summary It is concluded that time-dependent Genesis simulations show the MaRIE XFEL can deliver the number of photons within the required bandwidth, provided a number of assumptions are met; the highest risks are associated with the electron beam driving the XFEL undulator; and risks associated with the undulator and/or distributed seeding technique may be evaluated or retired by performing early validation experiments.

[Professor LIN Guohua's experience of gold implantation at acupoint for rheumatoid arthritis].

Science.gov (United States)

Li, Jingjing; Pei, Wenya

2015-12-01

Based on the pathogenesis and symptom of rheumatoid arthritis (RA), professor LIN Guohua's unique opinion and method for RA in clinical treatment are summarized and analyzed. In the opinion of Professor Lin, RA is considered as "Jinbi" and "Gubi" in TCM, which is caused by deficient root with superficial excess. Based on the symptoms of RA, attention should be focused on lung-kidney diagnosis and treatment, and gold and catgut implantation at acupoint can be mutually combined, which is aimed to provide a special and effective method for clinical treatment of RA.

A jolly good call for Marie Curie Fellows

CERN Multimedia

2009-01-01

A new funding opportunity to train young researchers has just been announced by the European Commission. One of the calls within FP7 Marie Curie Actions requests proposals for Initial Training Network (ITN) projects, with a deadline of 22 December 2009. Project proposals are strongly encouraged at CERN and authors can receive support and guidance from the Marie Curie Steering Group. Winnie Wong: "I wouldn’t have considered a PhD if I hadn’t been a Marie Curie fellow" Dan Savu: "It’s the best of both worlds: training plus working in an international organisation" ITN projects have one key aim: training. Academic and industrial partners work together to form a network to recruit and train Marie Curie Fellows. Fellows are young researchers (typically PhD-level) from any country who combine project-based research with tailor-made training programmes, ...

Meet EPA Scientist Marie O'Shea, Ph.D.

Science.gov (United States)

EPA Scientist Dr. Marie O'Shea is Region 2's Liaison to the Agency's Office of Research and Development (ORD). Marie has a background in research on urban watershed management, focused on characterizing and controlling nutrients in stormwater runoff.

Eesti Päevaleht korjas kolm pressipreemiat / Mari Rebane

Index Scriptorium Estoniae

Rebane, Mari

2006-01-01

Eile jagas Eesti Ajalehtede Liit 2005. aasta ajakirjandussaavutuste eest preemiaid. Eesti Päevaleht sai kujundusauhinna esikaane ja uudiskülgede eest ning arvamusloo preemia. Esikülje kujundusauhinna sai "Eesti Päevalehe" peakunstnik Merike Pinn. Parimateks uudisfoto autoriteks tunnistati Andras Kralla "Äripäevast" ja Margus Ansu "Tartu Postimehest", parimateks olemusfoto autoriteks Raul Mee "Äripäevast" ja Sille Annuk "Tartu Postimehest"

Genome packaging in EL and Lin68, two giant phiKZ-like bacteriophages of P. aeruginosa

International Nuclear Information System (INIS)

Sokolova, O.S.; Shaburova, O.V.; Pechnikova, E.V.; Shaytan, A.K.; Krylov, S.V.; Kiselev, N.A.; Krylov, V.N.

2014-01-01

A unique feature of the Pseudomonas aeruginosa giant phage phiKZ is its way of genome packaging onto a spool-like protein structure, the inner body. Until recently, no similar structures have been detected in other phages. We have studied DNA packaging in P. aeruginosa phages EL and Lin68 using cryo-electron microscopy and revealed the presence of inner bodies. The shape and positioning of the inner body and the density of the DNA packaging in EL are different from those found in phiKZ and Lin68. This internal organization explains how the shorter EL genome is packed into a large EL capsid, which has the same external dimensions as the capsids of phiKZ and Lin68. The similarity in the structural organization in EL and other phiKZ-like phages indicates that EL is phylogenetically related to other phiKZ-like phages, and, despite the lack of detectable DNA homology, EL, phiKZ, and Lin68 descend from a common ancestor. - Highlights: • We performed a comparative structural study of giant P. aeruginosa phages: EL, Lin68 and phiKZ. • We revealed that the inner body is a common feature in giant phages. • The phage genome size correlates with the overall dimensions of the inner body

Genome packaging in EL and Lin68, two giant phiKZ-like bacteriophages of P. aeruginosa

Energy Technology Data Exchange (ETDEWEB)

Sokolova, O.S., E-mail: sokolova@mail.bio.msu.ru [M.V. Lomonosov Moscow State University, Moscow (Russian Federation); A.V. Shoubnikov Institute of Crystallography RAS, Moscow (Russian Federation); Shaburova, O.V. [I.I. Mechnikov Research Institute of Vaccines and Sera, RAMS, Moscow (Russian Federation); Pechnikova, E.V. [A.V. Shoubnikov Institute of Crystallography RAS, Moscow (Russian Federation); Shaytan, A.K. [M.V. Lomonosov Moscow State University, Moscow (Russian Federation); Krylov, S.V. [I.I. Mechnikov Research Institute of Vaccines and Sera, RAMS, Moscow (Russian Federation); Kiselev, N.A. [A.V. Shoubnikov Institute of Crystallography RAS, Moscow (Russian Federation); Krylov, V.N. [I.I. Mechnikov Research Institute of Vaccines and Sera, RAMS, Moscow (Russian Federation)

2014-11-15

A unique feature of the Pseudomonas aeruginosa giant phage phiKZ is its way of genome packaging onto a spool-like protein structure, the inner body. Until recently, no similar structures have been detected in other phages. We have studied DNA packaging in P. aeruginosa phages EL and Lin68 using cryo-electron microscopy and revealed the presence of inner bodies. The shape and positioning of the inner body and the density of the DNA packaging in EL are different from those found in phiKZ and Lin68. This internal organization explains how the shorter EL genome is packed into a large EL capsid, which has the same external dimensions as the capsids of phiKZ and Lin68. The similarity in the structural organization in EL and other phiKZ-like phages indicates that EL is phylogenetically related to other phiKZ-like phages, and, despite the lack of detectable DNA homology, EL, phiKZ, and Lin68 descend from a common ancestor. - Highlights: • We performed a comparative structural study of giant P. aeruginosa phages: EL, Lin68 and phiKZ. • We revealed that the inner body is a common feature in giant phages. • The phage genome size correlates with the overall dimensions of the inner body.

Farewell Jean-Marie Good Luck Eva Welcome back Franz

CERN Multimedia

2001-01-01

At the farewell reception offered by the Director-General, Professor Luciano Maiani, on the occasion of Jean-Marie Dufour's retirement from CERN, three generations of CERN Legal Counsel met. From right to left: Jean-Marie Dufour, who retires on 30 November 2001, after 35 years of service. Eva-Maria Gröniger-Voss, who takes over from Jean-Marie Dufour on 1st December 2001. Ambassador Franz Schmid, CERN Legal Counsel from 1971 to 1974.

ANDRA - R and D programme 2013-2016. Executive summary

International Nuclear Information System (INIS)

2014-03-01

As the ANDRA has defined three strategic orientations for the years to come (period 2013-2016), respectively to prepare the decisions and the construction for the storage of high-level, intermediate-level-long-lived and low-level-long-lived wastes, to guarantee a high level of safety and to improve customer's satisfaction regarding the storage of their ultimate very-low-level and low-and-intermediate-level-short-lived wastes, and to provide and valorise innovating solutions for an optimised management of radioactive wastes, this report presents the different fields of research and development aimed at operational objectives associated with this strategic orientations. This R and D programme is herein presented in five main themes: to preserve the rare source of storage sites, to define requirements and needs-related technical specifications and to adapt them to knowledge progress, to support storage construction and exploitation operations, to define and exploit techniques and networks of control and information, and to optimise materials used in storage

Identification and Characterization of Genes That Interact with Lin-12 in Caenorhabditis Elegans

OpenAIRE

Tax, F. E.; Thomas, J. H.; Ferguson, E. L.; Horvitz, H. R.

1997-01-01

We identified and characterized 14 extragenic mutations that suppressed the dominant egg-laying defect of certain lin-12 gain-of-function mutations. These suppressors defined seven genes: sup-17, lag-2, sel-4, sel-5, sel-6, sel-7 and sel-8. Mutations in six of the genes are recessive suppressors, whereas the two mutations that define the seventh gene, lag-2, are semi-dominant suppressors. These suppressor mutations were able to suppress other lin-12 gain-of-function mutations. The suppressor ...

Variational principles of fluid mechanics and electromagnetism: imposition and neglect of the Lin constraint

International Nuclear Information System (INIS)

Allen, R.R. Jr.

1987-01-01

The Lin constraint has been utilized by a number of authors who have sought to develop Eulerian variational principles in both fluid mechanics and electromagnetics (or plasmadynamics). This dissertation first reviews the work of earlier authors concerning the development of variational principles in both the Eulerian and Lagrangian nomenclatures. In the process, it is shown whether or not the Euler-Lagrange equations that result from the variational principles are equivalent to the generally accepted equations of motion. In particular, it is shown in the case of several Eulerian variational principles that imposition of the Lin constraint results in Euler-Lagrange equations equivalent to the generally accepted equations of motion, whereas neglect of the Lin constraint results in restrictive Euler-Lagrange equations. In an effort to improve the physical motivation behind introduction of the Lin constraint, a new variational constraint is developed based on teh concept of surface forces within a fluid. Additionally, it is shown that a quantity often referred to as the canonical momentum of a charged fluid is not always a constant of the motion of the fluid; and it is demonstrated that there does not exist an unconstrained Eulerian variational principle giving rise to the generally accepted equations of motion for both a perfect fluid and a cold, electromagnetic fluid

Engineering international relations / Maris Riekstins ; interv. Talis Saule Archdeacon

Index Scriptorium Estoniae

Riekstins, Maris

2008-01-01

Läti annab peatselt Läänemeremaade Nõukogu eesistuja teatepulga üle Taanile. Läti välisminister Maris Riekstins Läänemeremaade Nõukogu teemadest ning suhetest Venemaaga. Maris Riekstins'i CV

Lin28a uses distinct mechanisms of binding to RNA and affects miRNA levels positively and negatively.

Science.gov (United States)

Nowak, Jakub Stanislaw; Hobor, Fruzsina; Downie Ruiz Velasco, Angela; Choudhury, Nila Roy; Heikel, Gregory; Kerr, Alastair; Ramos, Andres; Michlewski, Gracjan

2017-03-01

Lin28a inhibits the biogenesis of let-7 miRNAs by triggering the polyuridylation and degradation of their precursors by terminal uridylyltransferases TUT4/7 and 3'-5' exoribonuclease Dis3l2, respectively. Previously, we showed that Lin28a also controls the production of neuro-specific miRNA-9 via a polyuridylation-independent mechanism. Here we reveal that the sequences and structural characteristics of pre-let-7 and pre-miRNA-9 are eliciting two distinct modes of binding to Lin28a. We present evidence that Dis3l2 controls miRNA-9 production. Finally, we show that the constitutive expression of untagged Lin28a during neuronal differentiation in vitro positively and negatively affects numerous other miRNAs. Our findings shed light on the role of Lin28a in differentiating cells and on the ways in which one RNA-binding protein can perform multiple roles in the regulation of RNA processing. © 2017 Nowak et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society.

Radioactive materials and waste. Planning Act of 28 June 2006. Consolidated version established by Andra

International Nuclear Information System (INIS)

2013-07-01

This document is the English translation of the Articles of the Planning Act No. 2006-739 of 28 June 2006 and of the articles L. 542-1 and following of the Environmental Code (as modified) concerning the Sustainable Management of Radioactive Materials and Waste. This translation is provided for convenience purposes only, the French version remaining the only valid and legally-binding version. In order to enhance readability, all articles relating to Andra's activities are consolidated in this self-supporting document

Spaces of Modernism: Ljubica Marić in Context

Czech Academy of Sciences Publication Activity Database

Bajgarová, Jitka

2010-01-01

Roč. 47, č. 1 (2010), s. 109-111 ISSN 0018-7003. [Spaces of Modernism: Ljubica Marić in Context. Beograd, 05.11.2009-07.11.2009] Institutional research plan: CEZ:AV0Z90580513 Keywords : Ljubica Marić * Serbian composer Subject RIV: AL - Art, Architecture, Cultural Heritage

Combustion of Pure, Hydrolyzed and Methyl Ester Formed of Jatropha Curcas Lin oil

Directory of Open Access Journals (Sweden)

Muhaji Muhaji

2015-10-01

Full Text Available The density and viscosity of vegetable oil are higher than that of diesel oil. Thus its direct combustion in the diesel engine results many problems. This research was conducted to investigate the flame characteristics of combustion of jatropha curcas lin in pure, hydrolyzed and methyl ester form. The results indicated that the combustion of pure jatropha curcas lin occurs in three stages, hydrolyzed in two stages    and methyl ester in one stage. For pure jatropha curcas lin, in the first stage, unsaturated fatty acid burned for  0.265 s.  It is followed by saturated fatty acid, burned for 0.389 s in the second stage. And, in the last stage is the burned of glycerol for 0.560 s. Meanwhile for hydrolyzed one, in the first stage, unsaturated fatty acid burned for 0.736 s, followed by saturated fatty acid, burned  for 0.326 s in the second stage. And the last, for methyl ester is the burned for 0.712 s. The highest burning rate was for methyl ester which was 0.003931cc/s. The energy releasing rate of methyl ester, which was for 13,628.67 kcal/(kg.s resembled that of diesel oil the most, while the lowest rate was for pure jatropha curcas lin which was 8,200.94 kcal/(kg.s. In addition, massive explosion occurred in the fuel containing unsaturated fatty acid and glycerol

Analysis of a lin-42/period Null Allele Implicates All Three Isoforms in Regulation of Caenorhabditis elegans Molting and Developmental Timing

Directory of Open Access Journals (Sweden)

Theresa L. B. Edelman

2016-12-01

Full Text Available The Caenorhabditis elegans heterochronic gene pathway regulates the relative timing of events during postembryonic development. lin-42, the worm homolog of the circadian clock gene, period, is a critical element of this pathway. lin-42 function has been defined by a set of hypomorphic alleles that cause precocious phenotypes, in which later developmental events, such as the terminal differentiation of hypodermal cells, occur too early. A subset of alleles also reveals a significant role for lin-42 in molting; larval stages are lengthened and ecdysis often fails in these mutant animals. lin-42 is a complex locus, encoding overlapping and nonoverlapping isoforms. Although existing alleles that affect subsets of isoforms have illuminated important and distinct roles for this gene in developmental timing, molting, and the decision to enter the alternative dauer state, it is essential to have a null allele to understand all of the roles of lin-42 and its individual isoforms. To remedy this problem and discover the null phenotype, we engineered an allele that deletes the entire lin-42 protein-coding region. lin-42 null mutants are homozygously viable, but have more severe phenotypes than observed in previously characterized hypomorphic alleles. We also provide additional evidence for this conclusion by using the null allele as a base for reintroducing different isoforms, showing that each isoform can provide heterochronic and molting pathway activities. Transcript levels of the nonoverlapping isoforms appear to be under coordinate temporal regulation, despite being driven by independent promoters. The lin-42 null allele will continue to be an important tool for dissecting the functions of lin-42 in molting and developmental timing.

TFA'Expo Exhibition on the next low level radioactive wastes storage center Andra - Aube Center. January - june 2003

International Nuclear Information System (INIS)

2003-01-01

In order to inform the public on the nuclear installations, the Andra this document on the next storage Center of the Aube, for the low level radioactive wastes. The six parts present, the wastes characteristics, the wastes management, the choice of the site, the organization of the TFA (very low activity wastes), the environmental impacts and the economical impacts. (A.L.B.)

LIN28 expression in malignant germ cell tumors down-regulates let-7 and increases oncogene levels

Science.gov (United States)

Murray, Matthew J.; Saini, Harpreet K.; Siegler, Charlotte A.; Hanning, Jennifer E.; Barker, Emily M.; van Dongen, Stijn; Ward, Dawn M.; Raby, Katie L.; Groves, Ian J.; Scarpini, Cinzia G.; Pett, Mark R.; Thornton, Claire M.; Enright, Anton J.; Nicholson, James C.; Coleman, Nicholas

2013-01-01

Despite their clinico-pathologic heterogeneity, malignant germ-cell-tumors (GCTs) share molecular abnormalities that are likely to be functionally important. In this study, we investigated the potential significance of down-regulation of the let-7 family of tumor-suppressor microRNAs in malignant-GCTs. Microarray results from pediatric and adult samples (n=45) showed that LIN28, the negative-regulator of let-7 biogenesis, was abundant in malignant-GCTs, regardless of patient age, tumor site or histologic subtype. Indeed, a strong negative-correlation existed between LIN28 and let-7 levels in specimens with matched datasets. Low let-7 levels were biologically significant, since the sequence complementary to the 2-7nt common let-7 seed ‘GAGGUA’ was enriched in the 3′untranslated regions of mRNAs up-regulated in pediatric and adult malignant-GCTs, compared with normal gonads (a mixture of germ cells and somatic cells). We identified 27 mRNA targets of let-7 that were up-regulated in malignant-GCT cells, confirming significant negative-correlations with let-7 levels. Among 16 mRNAs examined in a largely independent set of specimens by qRT-PCR, we defined negative-associations with let-7e levels for six oncogenes, including MYCN, AURKB, CCNF, RRM2, MKI67 and C12orf5 (when including normal control tissues). Importantly, LIN28 depletion in malignant-GCT cells restored let-7 levels and repressed all of these oncogenic let-7 mRNA targets, with LIN28 levels correlating with cell proliferation and MYCN levels. Conversely, ectopic expression of let-7e was sufficient to reduce proliferation and down-regulate MYCN, AURKB and LIN28, the latter via a double-negative feedback loop. We concluded that the LIN28/let-7 pathway has a critical pathobiological role in malignant-GCTs and therefore offers a promising target for therapeutic intervention. PMID:23774216

A role for Lin28 in primordial germ cell development and germ cell malignancy

Science.gov (United States)

West, Jason A.; Viswanathan, Srinivas R.; Yabuuchi, Akiko; Cunniff, Kerianne; Takeuchi, Ayumu; Park, In-Hyun; Sero, Julia E.; Zhu, Hao; Perez-Atayde, Antonio; Frazier, A. Lindsay; Surani, M. Azim; Daley, George Q.

2009-01-01

The rarity and inaccessibility of the earliest primordial germ cells (PGCs) in the mouse embryo thwarts efforts to investigate molecular mechanisms of germ cell specification. Stella marks the minute founder population of the germ lineage1,2. Here we differentiate mouse embryonic stem cells (ESCs) carrying a Stella transgenic reporter into putative PGCs in vitro. The Stella+ cells possess a transcriptional profile similar to embryo-derived PGCs, and like their counterparts in vivo, lose imprints in a time-dependent manner. Using inhibitory RNAs to screen candidate genes for effects on the development of Stella+ cells in vitro, we discovered that Lin28, a negative regulator of let-7 microRNA processing3-6, is essential for proper PGC development. We further show that Blimp1, a let-7 target and a master regulator of PGC specification7-9, can rescue the effect of Lin28-deficiency during PGC development, thereby establishing a mechanism of action for Lin28 during PGC specification. Over-expression of Lin28 promotes formation of Stella+ cells in vitro and PGCs in chimeric embryos, and is associated with human germ cell tumours. The differentiation of putative PGCs from ESCs in vitro recapitulates the early stages of gamete development in vivo, and provides an accessible system for discovering novel genes involved in germ cell development and malignancy. PMID:19578360

LIN7A depletion disrupts cerebral cortex development, contributing to intellectual disability in 12q21-deletion syndrome.

Directory of Open Access Journals (Sweden)

Ayumi Matsumoto

Full Text Available Interstitial deletion of 12q21 has been reported in four cases, which share several common clinical features, including intellectual disability (ID, low-set ears, and minor cardiac abnormalities. Comparative genomic hybridization (CGH analysis using the Agilent Human Genome CGH 180K array was performed with the genomic DNA from a two-year-old Japanese boy with these symptoms, as well as hypoplasia of the corpus callosum. Consequently, a 14 Mb deletion at 12q21.2-q21.33 (nt. 77 203 574-91 264 613 bp, which includes 72 genes, was detected. Of these, we focused on LIN7A, which encodes a scaffold protein that is important for synaptic function, as a possible responsible gene for ID, and we analyzed its role in cerebral cortex development. Western blotting analyses revealed that Lin-7A is expressed on embryonic day (E 13.5, and gradually increases in the mouse brain during the embryonic stage. Biochemical fractionation resulted in the enrichment of Lin-7A in the presynaptic fraction. Suppression of Lin-7A expression by RNAi, using in utero electroporation on E14.5, delayed neuronal migration on postnatal day (P 2, and Lin-7A-deficient neurons remained in the lower zone of the cortical plate and the intermediate zone. In addition, when Lin-7A was silenced in cortical neurons in one hemisphere, axonal growth in the contralateral hemisphere was delayed; development of these neurons was disrupted such that one half did not extend into the contralateral hemisphere after leaving the corpus callosum. Taken together, LIN7A is a candidate gene responsible for 12q21-deletion syndrome, and abnormal neuronal migration and interhemispheric axon development may contribute to ID and corpus callosum hypoplasia, respectively.

ANDRA - National Radioactive Waste Management Agency. Activity report 2006. Management report - Financial statements 2006

International Nuclear Information System (INIS)

2007-06-01

Created in 1979 within the CEA, the National Radioactive Waste Management Agency (ANDRA) was established by the December 1991 Waste Act as a public body in charge of the long-term management of all radioactive waste, under the supervision of the Ministry of Ecology, Energy, Sustainable Development and the Sea (formerly the Ministry of Industry and the Ministry of Environment), and the Ministry of Research. Its 3 basic missions were extended and their funding secured through the 2006 Planning Act: - a R and D mission to propose safe long-term solution for radioactive waste without current disposal system; this mission includes long-term storage, since the 2006 Planning Act, in order to propose interim solutions while final ones are being studied; - an industrial mission concerning, on one hand, waste acceptance criteria and control and, on the other hand, siting, construction, operation, closure and monitoring of repositories. This mission includes as well a public service mission in terms of i) collection of waste of the 'small-scale nuclear activities' producers or owners (including the so-called 'household' radioactive waste, i.e. waste owned by private individuals) and ii) clean-up and rehabilitation of orphan polluted sites; - an information mission, notably through the regular publication of the National Inventory of radioactive materials and waste. This mission includes as well an active policy of dialogue with stakeholders both at national and local level. This document is the activity report with the management and financial statements report of the Andra for the year 2006

Functional comparison of the nematode Hox gene lin-39 in C. elegans and P. pacificus reveals evolutionary conservation of protein function despite divergence of primary sequences.

Science.gov (United States)

Grandien, K; Sommer, R J

2001-08-15

Hox transcription factors have been implicated in playing a central role in the evolution of animal morphology. Many studies indicate the evolutionary importance of regulatory changes in Hox genes, but little is known about the role of functional changes in Hox proteins. In the nematodes Pristionchus pacificus and Caenorhabditis elegans, developmental processes can be compared at the cellular, genetic, and molecular levels and differences in gene function can be identified. The Hox gene lin-39 is involved in the regulation of nematode vulva development. Comparison of known lin-39 mutations in P. pacificus and C. elegans revealed both conservation and changes of gene function. Here, we study evolutionary changes of lin-39 function using hybrid transgenes and site-directed mutagenesis in an in vivo assay using C. elegans lin-39 mutants. Our data show that despite the functional differences of LIN-39 between the two species, Ppa-LIN-39, when driven by Cel-lin-39 regulatory elements, can functionally replace Cel-lin-39. Furthermore, we show that the MAPK docking and phosphorylation motifs unique for Cel-LIN-39 are dispensable for Cel-lin-39 function. Therefore, the evolution of lin-39 function is driven by changes in regulatory elements rather than changes in the protein itself.

Lin28a uses distinct mechanisms of binding to RNA and affects miRNA levels positively and negatively

OpenAIRE

Nowak, Jakub Stanislaw; Hobor, Fruzsina; Downie Ruiz Velasco, Angela; Choudhury, Nila Roy; Heikel, Gregory; Kerr, Alastair; Ramos, Andres; Michlewski, Gracjan

2017-01-01

Lin28a inhibits the biogenesis of let-7 miRNAs by triggering the polyuridylation and degradation of their precursors by terminal uridylyltransferases TUT4/7 and 3’-5’ exoribonuclease Dis3l2, respectively. Previously, we showed that Lin28a also controls the production of neuro-specific miRNA-9 via a polyuridylation-independent mechanism. Here we reveal that the sequences and structural characteristics of pre-let-7 and pre-miRNA-9 are eliciting two distinct modes of binding to Lin28a. We presen...

Response to Niklasson's comment on Lin, et al. (2012) : "the relation between postural movement and bilateral motor integration".

Science.gov (United States)

Lin, Chin-Kai; Kuo, Bor-Chen; Wu, Huey-Min

2014-10-01

In the study of Lin, Wu, Lin, Wu, Wu, Kuo, and Yeung (2012 ), the relationship between the validity of postural movement and bilateral motor integration in terms of sensory integration theory was examined. Postural movement is the ability to use the antigravity postures required for stabilization of the neck, trunk and upper extremities via muscle co-contractions in the neck and upper extremities, and balance. Niklasson's (2013 ) comment argued that postural movement should include primitive reflexes in terms of the general abilities approach. Niklasson (2013 ) focused on the efficacy of the treatment rather than the theoretical frameworks implied in the therapeutic activities. For that purpose Lin, et al. (2012 ) used sensory integration as the theoretical foundation, and the relationship between postural movement and bilateral motor integration was assessed via empirical data. The result of Lin, et al. (2012 ) was offered as a theoretical reference for therapeutic activities.

Avangardistid Moskvas / Mari Sobolev

Index Scriptorium Estoniae

Sobolev, Mari, 1968-

2000-01-01

Valdek Alberi ja Taave Tuutma videoinstallatsioonist "Think different" näitusel "Salon 2000" Moskva Kunstnike Keskmajas 16.-26. III. Kuraator Mari Sobolev. Eesti väljapaneku vastukajast ja Jüri Arrakust, kelle maalid olid näitusel "Balti meistrid", ajalehes "Kommersant". Moskva kunstinäitustest.

The let-7/Lin28 axis regulates activation of hepatic stellate cells in alcoholic liver injury.

Science.gov (United States)

McDaniel, Kelly; Huang, Li; Sato, Keisaku; Wu, Nan; Annable, Tami; Zhou, Tianhao; Ramos-Lorenzo, Sugeily; Wan, Ying; Huang, Qiaobing; Francis, Heather; Glaser, Shannon; Tsukamoto, Hidekazu; Alpini, Gianfranco; Meng, Fanyin

2017-07-07

The let-7/Lin28 axis is associated with the regulation of key cellular regulatory genes known as microRNAs in various human disorders and cancer development. This study evaluated the role of the let-7/Lin28 axis in regulating a mesenchymal phenotype of hepatic stellate cells in alcoholic liver injury. We identified that ethanol feeding significantly down-regulated several members of the let-7 family in mouse liver, including let-7a and let-7b. Similarly, the treatment of human hepatic stellate cells (HSCs) with lipopolysaccharide (LPS) and transforming growth factor-β (TGF-β) significantly decreased the expressions of let-7a and let-7b. Conversely, overexpression of let-7a and let-7b suppressed the myofibroblastic activation of cultured human HSCs induced by LPS and TGF-β, as evidenced by repressed ACTA2 (α-actin 2), COL1A1 (collagen 1A1), TIMP1 (TIMP metallopeptidase inhibitor 1), and FN1 (fibronectin 1); this supports the notion that HSC activation is controlled by let-7. A combination of bioinformatics, dual-luciferase reporter assay, and Western blot analysis revealed that Lin28B and high-mobility group AT-hook (HMGA2) were the direct targets of let-7a and let-7b. Furthermore, Lin28B deficiency increased the expression of let-7a/let-7b as well as reduced HSC activation and liver fibrosis in mice with alcoholic liver injury. This feedback regulation of let-7 by Lin28B is verified in hepatic stellate cells isolated by laser capture microdissection from the model. The identification of the let-7/Lin28 axis as an important regulator of HSC activation as well as its upstream modulators and down-stream targets will provide insights into the involvement of altered microRNA expression in contributing to the pathogenesis of alcoholic liver fibrosis and novel therapeutic approaches for human alcoholic liver diseases. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

[Marie Heiberg. Üks naine kurbade silmadega] / Marko Mägi

Index Scriptorium Estoniae

Mägi, Marko

2010-01-01

Arvustus: Heiberg, Marie. Üks naine kurbade silmadega : Eesti luuletaja Marie Heibergi õnne ja valu, rõõmu ja mure lugu kirjades / [koostajad Iivi Lepik, Kirsten Simmo]. Tallinn : Eesti Teatri- ja Muusikamuuseum : SE & JS, 2010

Kunst linnaruumi, kunst vaatajani! : Madalmaad / Kirke Kangro

Index Scriptorium Estoniae

Kangro, Kirke, 1975-

2004-01-01

Skulptuurinäitusest "Den Haag Sculptuur 2004" Haagi kesklinnas. Sümpoosioni peateemaks "Giants: European Conversation Pieces / Hiiglased: Euroopa vestluskillud". Kuraator Marie Jeanne de Rooij. Balint Havasi ja Andras Galiku (Little Warsaw, Ungari) võidutööst, Damien Hirsti (Inglismaa), Esther Brugginki ja Tom Claasseni (Holland), Anton Cierny (Slovakkia), Monika Sosnowska (Poola) ning Eesti esindanud Kirke Kangro tööst

Marie and Pierre Curie. Life in extremes

International Nuclear Information System (INIS)

Roethlein, Brigitte

2008-01-01

In Paris in 1894, two young physicists fall in love: Marie Sklodowska and Pierre Curie. They get married and make great contributions to science, research radioactivity and discover new chemical elements. The marriage of Marie and Pierre Curie is quite modern: They work together as equals, share their thoughts and pursue their plans together as partners. They share an absolute interest in science, a love of nature, and a sceptic attitude towards the sophisticated society of the Belle Epoque. They are together 24 hours a day with hardly ever any disagreement. Whenever one of them is ill - which is quite often because of the high level of radioactivity in their laboratory -, the other will nurse him or her. After only twelve years of mutual love, Pierre Curie dies. Marie raises their two daughters on her own and continues her research. In 1911, she will be the first scientist that ever gets a second Nobel Prize. (orig.) [de

Experimental Physical Sciences Vistas: MaRIE (draft)

Energy Technology Data Exchange (ETDEWEB)

Shlachter, Jack [Los Alamos National Laboratory

2010-09-08

To achieve breakthrough scientific discoveries in the 21st century, a convergence and integration of world-leading experimental facilities and capabilities with theory, modeling, and simulation is necessary. In this issue of Experimental Physical Sciences Vistas, I am excited to present our plans for Los Alamos National Laboratory's future flagship experimental facility, MaRIE (Matter-Radiation Interactions in Extremes). MaRIE is a facility that will provide transformational understanding of matter in extreme conditions required to reduce or resolve key weapons performance uncertainties, develop the materials needed for advanced energy systems, and transform our ability to create materials by design. Our unique role in materials science starting with the Manhattan Project has positioned us well to develop a contemporary materials strategy pushing the frontiers of controlled functionality - the design and tailoring of a material for the unique demands of a specific application. Controlled functionality requires improvement in understanding of the structure and properties of materials in order to synthesize and process materials with unique characteristics. In the nuclear weapons program today, improving data and models to increase confidence in the stockpile can take years from concept to new knowledge. Our goal with MaRIE is to accelerate this process by enhancing predictive capability - the ability to compute a priori the observables of an experiment or test and pertinent confidence intervals using verified and validated simulation tools. It is a science-based approach that includes the use of advanced experimental tools, theoretical models, and multi-physics codes, simultaneously dealing with multiple aspects of physical operation of a system that are needed to develop an increasingly mature predictive capability. This same approach is needed to accelerate improvements to other systems such as nuclear reactors. MaRIE will be valuable to many national

Marie and Irene Curie. The first female Nobel Prize winners; Marie en IreneCurie. De eerste vrouwelijke Nobelprijswinnaars

Energy Technology Data Exchange (ETDEWEB)

Noordenbos, G. [Joke Smit Instituut voor Vrouwenstudies, Universiteit Leiden, Leiden (Netherlands)

2003-07-01

Marie Curie was awarded the Nobel Prize in 1903 and in 1911. Also her daughter, Irene Joliot-Curie, received a Nobel Prize for science in 1935. In this book an overview is given of the academic world at that time: limited access to universities for women, the carriers of both women in physics and their pioneering research and discoveries, the refusal of Marie Curie by the French Academy of Sciences, the awarding of the Nobel Prize and the assignment of Irene Joliot-Curie as the first female minister in France, the impact of the two World Wars, their married and private lives and the constant smear campaign of the press against both women. The lives and works of both women are hold against the light of the present position of women in physical sciences. [Dutch] In 1903, precies honderd jaar geleden, ontving Marie Curie als eerste vrouw de Nobelprijs voor de Wetenschap, gevolgd door een tweede Nobelprijs in 1911. Ook haar dochter Irene Joliot-Curie kreeg de Nobelprijs voor de wetenschap in 1935. Marie and Irene Curie schetst een breed beeld van de academische wereld waarin beide vrouwen zich bewogen: de beperkte toegang van vrouwen tot de universiteit, hun carrisres in de natuurkunde en baanbrekende ontdekkingen, de afwijzing van Marie door de Franse Academie des Sciences, de toekenning van de Nobelprijs en de benoeming van Irene als eerste vrouwelijke minister in Frankrijk, de invloed van de twee Wereldoorlogen, hun huwelijks- en priveleven en de niet aflatende hetze van de pers tegen beiden. In de door mannen gedomineerde wereld van de natuurwetenschappen liep de uitzonderingspositie van beide vrouwen als rode draad door hun curieuze levens. Het leven en werk van de Curies wordt geactualiseerd door deze tegen het licht te houden van de huidige positie van vrouwen in de natuurwetenschappen. Het bereiken van de top van de wetenschap door vrouwen blijkt nog steeds uitzonderlijk.

Mary as Mother in the Flores de Mayo in Poblacion, Oslob

Directory of Open Access Journals (Sweden)

Patricia Marion Y. Lopez

2016-06-01

Full Text Available The paper reflects on the meanings of the Flores de Mayo ritual as performed in a town on the southeastern coast of Cebu through the examination of Mary as a “semantically open” symbol. The essay illustrates how ideas about Mary are constructed through the discourse of the Church and are in turn, reinforced through a Church-instituted and regulated ritual. An analysis of selected elements of the ritual however, reveals that the symbol of Mary has the potential to hold “other” kinds of meanings that slip in between “official” and “unofficial” discourses, highlighting how Mary continues to be a negotiated field between church authorities and the popular faithful.

Special Workshop of Marie Curie Fellows on Research and Training in Physics and Technology

CERN Multimedia

Patrice Loiez

2002-01-01

Photo 0210006_07a: Prof. L. Maiani, Director General of CERN. Addressing the Marie Curie Worshop held at CERN 3-4 October 2002. Title of this talk:"Function of Large-scale Facilities and Centres of Excellence". Photo 0210006_14a: Prof. L. Maiani, Director General of CERN. Addressing the Marie Curie Worshop held at CERN 3-4 October 2002. Title of this talk:"Function of Large-scale Facilities and Centres of Excellence". Photo 0210006_22: Dr. David Plane (CERN) introducing Dr. Theodore Papazoglou from the European Commission. Addressing the Marie Curie Worshop held at CERN 3-4 October 2002. Title of this talk:"Marie Curie Fellowships in the 6th Framework Programme". Photo 0210006_28a: Dr. Nora Brambilla, Vice-President of Marie Curie Fellow Association, INFN and Dept. of Physics, University of Milan. Addressing the Marie-Curie Worshop held at CERN 3-4 October 2002. Title of this talk:"Marie Curie Fellows Association". Photo 0210006_29a: Dr. Nora Brambilla, Vice-President of Marie Curie Fellow Association, INFN a...

ANDRA - National Radioactive Waste Management Agency. 2014 Activity report - Responsibility in action. Financial report 2014

International Nuclear Information System (INIS)

2015-01-01

Created in 1979 within the CEA, the National Radioactive Waste Management Agency (ANDRA) was established by the December 1991 Waste Act as a public body in charge of the long-term management of all radioactive waste, under the supervision of the Ministry of Ecology, Energy, Sustainable Development and the Sea (formerly the Ministry of Industry and the Ministry of Environment), and the Ministry of Research. Its 3 basic missions were extended and their funding secured through the 2006 Planning Act: - a R and D mission to propose safe long-term solution for radioactive waste without current disposal system; this mission includes long-term storage, since the 2006 Planning Act, in order to propose interim solutions while final ones are being studied; - an industrial mission concerning, on one hand, waste acceptance criteria and control and, on the other hand, siting, construction, operation, closure and monitoring of repositories. This mission includes as well a public service mission in terms of i) collection of waste of the 'small-scale nuclear activities' producers or owners (including the so-called 'household' radioactive waste, i.e. waste owned by private individuals) and ii) clean-up and rehabilitation of orphan polluted sites; - an information mission, notably through the regular publication of the National Inventory of radioactive materials and waste. This mission includes as well an active policy of dialogue with stakeholders both at national and local level. This document is the activity and financial report of the Andra for the year 2014

ANDRA - National Radioactive Waste Management Agency. Activity report and sustainable development 2013. Financial report 2013

International Nuclear Information System (INIS)

2014-01-01

Created in 1979 within the CEA, the National Radioactive Waste Management Agency (ANDRA) was established by the December 1991 Waste Act as a public body in charge of the long-term management of all radioactive waste, under the supervision of the Ministry of Ecology, Energy, Sustainable Development and the Sea (formerly the Ministry of Industry and the Ministry of Environment), and the Ministry of Research. Its 3 basic missions were extended and their funding secured through the 2006 Planning Act: - a R and D mission to propose safe long-term solution for radioactive waste without current disposal system; this mission includes long-term storage, since the 2006 Planning Act, in order to propose interim solutions while final ones are being studied; - an industrial mission concerning, on one hand, waste acceptance criteria and control and, on the other hand, siting, construction, operation, closure and monitoring of repositories. This mission includes as well a public service mission in terms of i) collection of waste of the 'small-scale nuclear activities' producers or owners (including the so-called 'household' radioactive waste, i.e. waste owned by private individuals) and ii) clean-up and rehabilitation of orphan polluted sites; - an information mission, notably through the regular publication of the National Inventory of radioactive materials and waste. This mission includes as well an active policy of dialogue with stakeholders both at national and local level. This document is the activity and Sustainable Development Report, with the financial report, of the Andra for the year 2013

Mary Leue: A Tribute.

Science.gov (United States)

Becker, Ellen; Becker, Larry; McPheeters, Tom; Mercogliano, Chris

1999-01-01

Mary Leue started the Free School, an independent, alternative elementary school in inner-city Albany (New York), based on open democratic education dedicated to the authentic lives of children. Other accomplishments include a community-investment organization, a magazine of alternative education, a magazine for empowering families, and a…

TFA'Expo Exhibition on the next low level radioactive wastes storage center Andra - Aube Center. January - june 2003; TFA'Expo exposition sur le futur Centre de stockage de dechets de tres faible activite Andra - Centre de l'Aube. Janvier - Juin 2003

Energy Technology Data Exchange (ETDEWEB)

NONE

2003-07-01

In order to inform the public on the nuclear installations, the Andra this document on the next storage Center of the Aube, for the low level radioactive wastes. The six parts present, the wastes characteristics, the wastes management, the choice of the site, the organization of the TFA (very low activity wastes), the environmental impacts and the economical impacts. (A.L.B.)

Eisma sadamahoone = Eisma port building / Mari Kurismaa ; kommenteerinud Krista Aren

Index Scriptorium Estoniae

Kurismaa, Mari, 1956-

2015-01-01

Eluruumid Eisma sadamahoones (Eisma küla, Vihula vald, Lääne-Virumaa). Sisekujunduse autorid Mari Kurismaa, Indrek Allmann; arhitekt Indrek Allmann (AB Pluss). Eesti Sisearhitektide Liidu aastapreemia 2014/2015 parima kodu eest. Lühidalt Mari Kurismaast ja Indrek Allmannist

Opposing Post-transcriptional Control of InR by FMRP and LIN-28 Adjusts Stem Cell-Based Tissue Growth

Directory of Open Access Journals (Sweden)

Arthur Luhur

2017-12-01

Full Text Available Summary: Although the intrinsic mechanisms that control whether stem cells divide symmetrically or asymmetrically underlie tissue growth and homeostasis, they remain poorly defined. We report that the RNA-binding protein fragile X mental retardation protein (FMRP limits the symmetric division, and resulting expansion, of the stem cell population during adaptive intestinal growth in Drosophila. The elevated insulin sensitivity that FMRP-deficient progenitor cells display contributes to their accelerated expansion, which is suppressed by the depletion of insulin-signaling components. This FMRP activity is mediated solely via a second conserved RNA-binding protein, LIN-28, known to boost insulin signaling in stem cells. Via LIN-28, FMRP controls progenitor cell behavior by post-transcriptionally repressing the level of insulin receptor (InR. This study identifies the stem cell-based mechanism by which FMRP controls tissue adaptation, and it raises the possibility that defective adaptive growth underlies the accelerated growth, gastrointestinal, and other symptoms that affect fragile X syndrome patients. : Luhur et al. report that FMRP acts via LIN-28 in progenitor cells to dampen the adaptive expansion of intestinal tissue in the fruit fly, raising the possibility that defective LIN28-mediated adaptive growth underlies some of the symptoms that affect fragile X syndrome patients. Keywords: FMRP, fmr1, LIN-28, insulin receptor, IIS, adaptive growth, tissue resizing, intestinal stem cell, insulin sensitivity

Mari Martin - vahelüli looja ja kandja vahel / Mari Martin ; intervjueerinud Tanel Veenre

Index Scriptorium Estoniae

Martin, Mari, 1983-

2009-01-01

Kalamari Promotioni tegevjuht, Tartu Ülikoolis majandust õppiv Mari Martin oma esimestest sammudest moemaailmas, kaubamärkide ReUse RePublic (premeeriti noorte äriideede võistlusel "Ajujaht 2009" 175000 krooniga) ja Tallinn Dolls loomisest, eesti disaineritest, unistustest seoses eesti disainiga

Electronic, web and internet platforms for communicating on radioactive waste management: the experience of ANDRA

International Nuclear Information System (INIS)

Eymard, J.

2006-01-01

ANDRA has been using e-tools and has had its own web-site since 1997. The site has been through 5 major upgrades since then. All the Agency's documents can be consulted and downloaded. Thus, electronic or web communication play a more and more important role as compared to classical instruments: 151453 hits in 2005, that is 37% up on 2004 and 119% up on 2003. One person, assigned from the communications division looks after the site. Assessments and analyses of the web-site use are performed through web surveys, online questionnaires and comments made by surfers

Mari Koger : "Arhitekte on palju. Tuleb leida õige" / Gitte Hint

Index Scriptorium Estoniae

Hint, Gitte

2003-01-01

Mari Koger (sünd. 1973) kodu kujundamisest, planeerimisest, valgustusest, värvidest, suhtlemisest kliendiga. Mari Kogerist, loetletud tema tehtud ühiskondlike ruumide sisekujundused aastast 2002. M. Koger töötab Boom.ee OÜ-s. Ill.: M. Kogeri värv. portree

Fragmented Encounters, Social Slippages: Lin Huiyin's "In Ninety-Nine Degree Heat"

Directory of Open Access Journals (Sweden)

Carles Prado-Fonts

2010-01-01

Full Text Available The article reads Lin Huiyin’s short story “In Ninety-Nine Degree Heat” (1934 in relation to the context of 1930s China, as an innovative literary work which combines elements from both the Chinese and the Western traditions, and as a text which informs readers not only of the problematic of class and gender issues in 1930s Chinese society but also of the context of the liuxuesheng who returns to China –like Lin Huiyin herself. Focusing on questions like otherness, representation, and encounters, the essay analyzes how the episodic narrative structure of Lin’s short story echoes social and representational discourses in post-May Fourth China, at the same time that it explores issues such as social inequality, otherness and alienation, which were crucial to the liuxuesheng, and which reflect Lin’s own experience as a returned and alienated liuxuesheng at the time.

Overexpression of Lin28b in Neural Stem Cells is Insufficient for Brain Tumor Formation, but Induces Pathological Lobulation of the Developing Cerebellum.

Science.gov (United States)

Wefers, Annika K; Lindner, Sven; Schulte, Johannes H; Schüller, Ulrich

2017-02-01

LIN28B is a homologue of the RNA-binding protein LIN28A and regulates gene expression during development and carcinogenesis. It is strongly upregulated in a variety of brain tumors, such as medulloblastoma, embryonal tumor with multilayered rosettes (ETMR), atypical teratoid/rhabdoid tumor (AT/RT), or glioblastoma, but the effect of an in vivo overexpression of LIN28B on the developing central nervous system is unknown. We generated transgenic mice that either overexpressed Lin28b in Math1-positive cerebellar granule neuron precursors or in a broad range of Nestin-positive neural precursors. Sections of the cerebellar vermis from adult Math1-Cre::lsl-Lin28b mice had an additional subfissure in lobule IV. Vermes from p0 and p7 Nestin-Cre::lsl-Lin28b mice appeared normal, but we found a pronounced vermal hypersublobulation at p15 and p21 in these mice. Also, the external granule cell layer (EGL) was thicker at p15 than in controls, contained more proliferating cells, and persisted up to p21. Consistently, some Pax6- and NeuN-positive cells were present in the EGL of Nestin-Cre::lsl-Lin28b mice even at p21, and we detected more NeuN-positive granule neuron precursors in the molecular layer (ML) as compared to control. Finally, we found some residual Pax2-positive precursors of inhibitory interneurons in the ML of Nestin-Cre::lsl-Lin28b mice at p21, which have already disappeared in controls. We conclude that while overexpression of LIN28B in Nestin-positive cells does not lead to tumor formation, it results in a protracted development of granule cells and inhibitory interneurons and leads to a hypersublobulation of the cerebellar vermis.

93 une urbanisation linéaire, dynamique demographique et ...

African Journals Online (AJOL)

Mohand

d'Alger, dans l'ensemble Sahel-Mitidja sur un linéaire côtier de 2 km. Rattaché administrativement à la daira de ... connait une dynamique démographique remar- quable, dans sa périphérie orientale - composé de l'ensemble Sahel-. Mitidja ..... «Etude agro-pédologique de la plaine de la Mitidja». Florin B.; Semoud N. 2010.

Dynamiques complexes et morphogenèse Introduction aux sciences non linéaires

CERN Document Server

Misbah, Chaouqi

2011-01-01

Les sciences non linéaires ont pour objet l’ensemble des phénomènes dont l’analyse résiste au principe de superposition. Elles concernent en grande partie les systèmes dits « complexes » dont l’interaction et l’interdépendance entre les parties empêchent de prédire précisément l’évolution du système. Pour expliquer ces phénomènes, deux approches complémentaires ont été proposées : la théorie des bifurcations et la théorie des catastrophes. Mais la pleine compréhension et la modélisation de la non-linéarité restent chacune un défi pour les scientifiques du XXIe siècle. C’est dans la perspective d’accompagner tous ceux qui voudront le relever que ce livre a été conçu. Son objectif est d’exposer au lecteur le langage et le formalisme nécessaires à l’étude de la non-linéarité. Partant d’exemples simples, pour ensuite atteindre un niveau d’abstraction visant l’universalité, l’auteur explore les divers scénarios possibles de bifurcations et les catastr...

[Analysis of acid rain characteristics of Lin'an Regional Background Station using long-term observation data].

Science.gov (United States)

Li, Zheng-Quan; Ma, Hao; Mao, Yu-Ding; Feng, Tao

2014-02-01

Using long-term observation data of acid rain at Lin'an Regional Background Station (Lin'an RBS), this paper studied the interannual and monthly variations of acid rain, the reasons for the variations, and the relationships between acid rain and meteorological factors. The results showed that interannual variation of acid rain at Lin'an RBS had a general increasing trend in which there were two obvious intensifying processes and two distinct weakening processes, during the period ranging from 1985 to 2012. In last two decades, the monthly variation of acid rain at Lin'an RBS indicated that rain acidity and frequency of severe acid rain were increasing but the frequency of weak acid rain was decreasing when moving towards bilateral side months of July. Acid rain occurrence was affected by rainfall intensity, wind speed and wind direction. High frequency of severe acid rain and low frequency of weak acid rain were on days with drizzle, but high frequency of weak acid rain and low frequency of severe acid rain occurred on rainstorm days. With wind speed upgrading, the frequency of acid rain and the proportion of severe acid rain were declining, the pH value of precipitation was reducing too. Another character is that daily dominant wind direction of weak acid rain majorly converged in S-W section ,however that of severe acid rain was more likely distributed in N-E section. The monthly variation of acid rain at Lin'an RBS was mainly attributed to precipitation variation, the increasing and decreasing of monthly incoming wind from SSE-WSW and NWN-ENE sections of wind direction. The interannual variation of acid rain could be due to the effects of energy consumption raising and significant green policies conducted in Zhejiang, Jiangsu and Shanghai.

ANDRA - National Radioactive Waste Management Agency. Activity report 2008 - Fostering dialogue and outreach. Management report - Financial statements at December 31, 2008. Annual Sustainable Development Report 2008 - From strategy to initial actions: Andra's sustained commitment

International Nuclear Information System (INIS)

2009-06-01

Created in 1979 within the CEA, the National Radioactive Waste Management Agency (ANDRA) was established by the December 1991 Waste Act as a public body in charge of the long-term management of all radioactive waste, under the supervision of the Ministry of Ecology, Energy, Sustainable Development and the Sea (formerly the Ministry of Industry and the Ministry of Environment), and the Ministry of Research. Its 3 basic missions were extended and their funding secured through the 2006 Planning Act: - a R and D mission to propose safe long-term solution for radioactive waste without current disposal system; this mission includes long-term storage, since the 2006 Planning Act, in order to propose interim solutions while final ones are being studied; - an industrial mission concerning, on one hand, waste acceptance criteria and control and, on the other hand, siting, construction, operation, closure and monitoring of repositories. This mission includes as well a public service mission in terms of i) collection of waste of the 'small-scale nuclear activities' producers or owners (including the so-called 'household' radioactive waste, i.e. waste owned by private individuals) and ii) clean-up and rehabilitation of orphan polluted sites; - an information mission, notably through the regular publication of the National Inventory of radioactive materials and waste. This mission includes as well an active policy of dialogue with stakeholders both at national and local level. This document is the activity report, with the management and financial statements report, and the Sustainable Development Report of the Andra for the year 2008

Hydrogeochemical investigations at the ANDRA Meuse/Haute-Marne underground research laboratory

International Nuclear Information System (INIS)

Vinsot, A.; Delay, J.; Rebours, H.

2006-01-01

In November 1999 Andra began building an Underground Research Laboratory (URL) in eastern France. The geological formation selected for this laboratory is a 130-meter thick argillaceous rock level. This clay rich layer is located at a 400 to 600 meter depth. To characterize the confining properties of the clay, pore water composition had to be studied. For this purpose an innovative device was designed for gas equilibration and direct sampling of the pore water. The experimental device consists of a vertical ascending borehole with a 5 meter long test interval at its far end in which a gas circulation is established. After a few weeks, due to the hydraulic gradient between the test interval and the rock formation, the water flows freely at a rate of 0.5 to 1.3 litters per month in the borehole and it is sampled. The chemical composition of this water is compared with a theoretical composition deduced from core analyses and thermodynamic modelling. (author)

2010-2012. Research and development at the ANDRA for storage projects

International Nuclear Information System (INIS)

2013-10-01

After a general presentation of research activities within the ANDRA (main steps and highlights between 2010 and 2012, composition of the scientific council, actions of mobilisation of the French and international scientific community), this report proposes a detailed overview of these R and D activities in different specific fields: the determination of the behaviour of the various components of a storage (studies on wastes, on the behaviour of geological layers and of underground works, on the interaction and chemistry of materials in a deep storage), the preparation of the construction of the future deep storage in its geological context, the design of the evolution of a storage within its environment (effect of oxidation, of transfer phenomena within the storage, within the geological environment, and within soils), the assessment of storage performance, the reversibility of the deep geological storage and its implications in time, and the actions information on results and valorisation (congresses, publications, research thesis)

Primordial dwarfism gene maintains Lin28 expression to safeguard embryonic stem cells from premature differentiation.

Science.gov (United States)

Dai, Qian; Luan, Guangxin; Deng, Li; Lei, Tingjun; Kang, Han; Song, Xu; Zhang, Yujun; Xiao, Zhi-Xiong; Li, Qintong

2014-05-08

Primordial dwarfism (PD) is characterized by global growth failure, both during embryogenesis and postnatally. Loss-of-function germline mutations in La ribonucleoprotein domain family, member 7 (LAPR7) have recently been linked to PD. Paradoxically, LARP7 deficiency was previously assumed to be associated with increased cell growth and proliferation via activation of positive transcription elongation factor b (P-TEFb). Here, we show that Larp7 deficiency likely does not significantly increase P-TEFb activity. We further discover that Larp7 knockdown does not affect pluripotency but instead primes embryonic stem cells (ESCs) for differentiation via downregulation of Lin28, a positive regulator of organismal growth. Mechanistically, we show that Larp7 interacts with a poly(A) polymerase Star-PAP to maintain Lin28 mRNA stability. We propose that proper regulation of Lin28 and PTEFb is essential for embryonic cells to achieve a sufficient number of cell divisions prior to differentiation and ultimately to maintain proper organismal size. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

Mary Magdalene, the Apostola of the Easter Morning: Changes in the Late Medieval Carthusian Office of St Mary Magdalene

Directory of Open Access Journals (Sweden)

Katarina Šter

2017-06-01

Full Text Available The Office of Mary Magdalene is one of the rare offices of the Carthusian liturgy that was changed after it had been established as a solemn feast with twelve lessons. In Matins, several chants changed their position or were even replaced by new ones. This article examines the relationship between the earlier and the later Office of St Mary Magdalene. Later corrections in the Lauds first antiphon, Maria stabat ad monumentum receive some special attention since they open new questions concerning the unity of the Carthusian liturgical tradition, and a possible connection between individual Carthusian manuscripts.

New explicit and exact solutions of the Benney–Kawahara–Lin equation

International Nuclear Information System (INIS)

Yuan-Xi, Xie

2009-01-01

In this paper, we present a combination method of constructing the explicit and exact solutions of nonlinear partial differential equations. And as an illustrative example, we apply the method to the Benney–Kawahara–Lin equation and derive its many explicit and exact solutions which are all new solutions. (general)

Välinäituse stendid = Outdoor exhibition stands / Gert Sarv, Galina Burnakova

Index Scriptorium Estoniae

Sarv, Gert, 1971-

2013-01-01

Eesti Sisearhitektide Liidu 2012. aasta parima eseme preemia pälvinud välinäituse stendidest Vanasadama Admiraliteedi basseini kaldapealsel. Autorid: Gert Sarv, Galina Burnakova, Loreida Hein. Sisearhitekti ja ESLi aastapreemiate žürii liikme Tea Tammelaane arvamus

Jean-Marie Dufour receives the Legion of Honour

CERN Multimedia

2001-01-01

French Ambassador Philippe Petit (left) presents the cross of Knight of the Légion d'Honneur to Jean-Marie Dufour. On Friday 22 June, Jean-Marie Dufour, Head of CERN's Legal Service, was made Knight of the Legion of Honour by Ambassador Philippe Petit, at a ceremony held at the Permanent Mission of France in Geneva. Ambassador Petit is Permanent Representative of France at the United Nations and French delegate at CERN. He was awarded the decoration in recognition of his services. He has played an active part in all the great stages of CERN's development, in fact, ranging from its scientific programmes, to its establishment in its Host States, Switzerland and France, and its opening up to the wider world. The ceremony took place in the presence of Professor Luciano Maiani. The award is an honour to CERN, and the Organization takes this opportunity to convey its friendliest congratulations to Jean-Marie Dufour, a committed European.

Phenotypic spectrum of dynamin 2 mutations in Charcot-Marie-Tooth neuropathy

NARCIS (Netherlands)

Claeys, Kristl G.; Züchner, Stephan; Kennerson, Marina; Berciano, José; Garcia, Antonio; Verhoeven, Kristien; Storey, Elsdon; Merory, John R.; Bienfait, Henriette M. E.; Lammens, Martin; Nelis, Eva; Baets, Jonathan; de Vriendt, Els; Berneman, Zwi N.; de Veuster, Ilse; Vance, Jefferey M.; Nicholson, Garth; Timmerman, Vincent; de Jonghe, Peter

2009-01-01

Dominant intermediate Charcot-Marie-Tooth neuropathy type B is caused by mutations in dynamin 2. We studied the clinical, haematological, electrophysiological and sural nerve biopsy findings in 34 patients belonging to six unrelated dominant intermediate Charcot-Marie-Tooth neuropathy type B

Deliberated opinion of the Environment Authority on the authorization of exploitation of the ANDRA's Centre of storage of very-low-activity radioactive wastes in Morvilliers and La Chaise (Aube)

International Nuclear Information System (INIS)

2011-01-01

This report proposes an environmental review of the exploitation authorization request submitted by the ANDRA for its centre of storage of very-low-activity radioactive wastes (CSTFA). After an indication of the main recommendations regarding the style and content of this request, this report presents and comments the project, indicates the concerned administrative procedures, and analyses, comments and discusses the project environmental review submitted by the ANDRA. This comprises an impact study which itself comprises an analysis of the initial condition, a justification of choices, an analysis of impacts on the environment and on health, of impacts on Natura 2000 sites, measures to avoid, reduce or compensate negative impacts, and an hazard study

In Remembrance: Mary Frances Lyon

Indian Academy of Sciences (India)

2014-12-25

Dec 25, 2014 ... turn came I told him that I wanted to work on X-chromosome inactivation. He asked ... are many students even in 2015 who get equally excited and curious about it. The 1961 .... (a) Mary Lyon in Kyoto, Japan, 1991. (b) During ...

Louis Leakey and Mary Leakey

Indian Academy of Sciences (India)

Permanent link: https://www.ias.ac.in/article/fulltext/reso/020/08/0667-0679. Keywords. Palaeoanthropology; human evolution; Louis Leakey; Mary Leakey; Africa; Olduvai gorge; fossil hominids. Author Affiliations. Rajan Gaur1. Department of Anthropology, Panjab University, Sector 14, Chandigarh UT 160 014, India ...

DPL-1 DP, LIN-35 Rb and EFL-1 E2F act with the MCD-1 zinc-finger protein to promote programmed cell death in Caenorhabditis elegans.

Science.gov (United States)

Reddien, Peter W; Andersen, Erik C; Huang, Michael C; Horvitz, H Robert

2007-04-01

The genes egl-1, ced-9, ced-4, and ced-3 play major roles in programmed cell death in Caenorhabditis elegans. To identify genes that have more subtle activities, we sought mutations that confer strong cell-death defects in a genetically sensitized mutant background. Specifically, we screened for mutations that enhance the cell-death defects caused by a partial loss-of-function allele of the ced-3 caspase gene. We identified mutations in two genes not previously known to affect cell death, dpl-1 and mcd-1 (modifier of cell death). dpl-1 encodes the C. elegans homolog of DP, the human E2F-heterodimerization partner. By testing genes known to interact with dpl-1, we identified roles in cell death for four additional genes: efl-1 E2F, lin-35 Rb, lin-37 Mip40, and lin-52 dLin52. mcd-1 encodes a novel protein that contains one zinc finger and that is synthetically required with lin-35 Rb for animal viability. dpl-1 and mcd-1 act with efl-1 E2F and lin-35 Rb to promote programmed cell death and do so by regulating the killing process rather than by affecting the decision between survival and death. We propose that the DPL-1 DP, MCD-1 zinc finger, EFL-1 E2F, LIN-35 Rb, LIN-37 Mip40, and LIN-52 dLin52 proteins act together in transcriptional regulation to promote programmed cell death.

Mary Grant Seacole: the first nurse practitioner.

Science.gov (United States)

Messmer, P R; Parchment, Y

1998-01-01

Mary Grant Seacole was born in 1805, in Kingston, Jamaica, to a Jamaican doctress (medicine woman) and a Scottish naval officer. Later Seacole became a doctress, nursing British soldiers during epidemics of cholera, dysentery, and yellow fever in Jamaica, Cuba, and Panama. After refusals by both the British government and Florence Nightingale to be allowed to practice in Scutari, she financed her own way to the scene of the Crimean War and then established the British Hotel to serve both the comfort and medical needs of the wounded soldiers. At night, Seacole worked side by side with Nightingale at Scutari as a volunteer nurse. Seacole's fame grew proportionately after she was seen helping wounded soldiers on the battlefields even while the battles were still raging. Seacole died on May 14, 1881, in London. One hundred years later, many members of the London black community, a few members of the Nurses Association of Jamaica and the Friends of Mary Seacole marched to her grave, honoring her as one of the greatest women of all times. Mary Grant Seacole rose above the barriers of racial prejudice and demonstrated the determinism, compassion, and caring that have became the hallmark of nurse practitioners.

The ANDRA, two years after the June 2006, 28 programming law. Assessment and perspectives for the Manche storage centre. Press conference of June 2008, 27

International Nuclear Information System (INIS)

2008-01-01

This report first presents the main activities of ANDRA (the French national agency for radioactive waste management), describes and comments the legal frame built up by the programming law of the June 2006, 28. It presents the Manche waste storage centre, its waste types, storage concept, cover and control, and actions to keep the memory of this site for the next generations. It gives an overview of ANDRA's missions, role as industrial operator, and financing, describes the three general interest missions (national inventory of radioactive materials and wastes, collection and processing of common usage radioactive objects, and decontamination of sites polluted by radioactivity), discusses the results obtained for the inventory. It presents the project of reversible deep storage of high and intermediate level and long life wastes (a facility is foreseen to operate in 2025), and the project of a hollow storage site for low level and long life wastes

GENII-LIN: a Multipurpose Health Physics Code Built on GENII-1.485

Directory of Open Access Journals (Sweden)

Marco Sumini

2006-10-01

Full Text Available The aim of the GENII-LIN project was to develop an open source multipurpose health physics code running on Linux platform, for calculating radiation dose and risk from radionuclides released to the environment. The general features of the GENII-LIN system include [1] capabilities for calculating radiation dose both for acute and chronic releases, with options for annual dose, committed dose and accumulated dose [2] capabilities for evaluating exposure pathways including direct exposure via water (swimming, boating, fishing, soil (buried and surface sources and air (semi-infinite cloud and finite cloud model, inhalation pathways and ingestion pathways. The release scenarios considered are: - acute release to air, from ground level or elevated sources, or to water; - chronic release to air, from ground level or elevated sources, or to water; - initial contamination of soil or surfaces. Keywords: radiation protection, Linux, health physics, risk analysis.

Kulturní hodnoty tzv. Mariánského trojúhelníku - Sloup, Vranov, Křtiny

OpenAIRE

Bezděková, Veronika

2009-01-01

In the Moravian Karst there are three big churches consecrated to The Virgin Mary. These are visited by many pilgrims and have their own calendar of pilgrimages. They are Vranov, Křtiny and Sloup. Churches in these towns are consecrated to The Virgin Mary: Vranov commemorates the birth of The Virgin Mary, Křtiny commemorates the name of The Virgin Mary and Sloup commemorates the sufferings of The Virgin Mary. So we talk about the triangle of The Virgin Mary. This term is the main point of my ...

Using Lin's method to solve Bykov's problems

Science.gov (United States)

Knobloch, Jürgen; Lamb, Jeroen S. W.; Webster, Kevin N.

2014-10-01

We consider nonwandering dynamics near heteroclinic cycles between two hyperbolic equilibria. The constituting heteroclinic connections are assumed to be such that one of them is transverse and isolated. Such heteroclinic cycles are associated with the termination of a branch of homoclinic solutions, and called T-points in this context. We study codimension-two T-points and their unfoldings in Rn. In our consideration we distinguish between cases with real and complex leading eigenvalues of the equilibria. In doing so we establish Lin's method as a unified approach to (re)gain and extend results of Bykov's seminal studies and related works. To a large extent our approach reduces the study to the discussion of intersections of lines and spirals in the plane. Case (RR): Under open conditions on the eigenvalues, there exist open sets in parameter space for which there exist periodic orbits close to the heteroclinic cycle. In addition, there exist two one-parameter families of homoclinic orbits to each of the saddle points p1 and p2.See Theorem 2.1 and Proposition 2.2 for precise statements and Fig. 2 for bifurcation diagrams. Cases (RC) and (CC): At the bifurcation point μ=0 and for each N≥2, there exists an invariant set S0N close to the heteroclinic cycle on which the first return map is topologically conjugated to a full shift on N symbols. For any fixed N≥2, the invariant set SμN persists for |μ| sufficiently small.In addition, there exist infinitely many transversal and non-transversal heteroclinic orbits connecting the saddle points p1 and p2 in a neighbourhood of μ=0, as well as infinitely many one-parameter families of homoclinic orbits to each of the saddle points.For full statements of the results see Theorem 2.3 and Propositions 2.4, 2.5 and Fig. 3 for bifurcation diagrams. The dynamics near T-points has been studied previously by Bykov [6-10], Glendinning and Sparrow [20], Kokubu [27,28] and Labouriau and Rodrigues [30,31,38]. See also the surveys

Topografia ficcional: a construção do espaço nos manuscritos de Osman Lins

Directory of Open Access Journals (Sweden)

Francisco José Gonçalves Lima Rocha

2013-01-01

Full Text Available In the construction of the narrative space of his final, unfinished novel, A cabeça levada em triunfo, Osman Lins operates both verbal, with notes planning, as iconically, through drawings. Will try to show that the author’s purpose is to clarify the topography of the work, because it establishes and harmonizes the technical functions - ie, like space, says Osman Lins, “frame” the character – and symbolic means, ie. how the space reflects, like all other elements of the work, the questioning of the head-body dichotomy.

On the reduction of generalized polylogarithms to Li_n and Li_2_,_2 and on the evaluation thereof

International Nuclear Information System (INIS)

Frellesvig, Hjalte; Tommasini, Damiano; Wever, Christopher

2016-01-01

We give expressions for all generalized polylogarithms up to weight four in terms of the functions log, Li_n, and Li_2_,_2, valid for arbitrary complex variables. Furthermore we provide algorithms for manipulation and numerical evaluation of Li_n and Li_2_,_2, and add codes in Mathematica and C++ implementing the results. With these results we calculate a number of previously unknown integrals, which we add in appendix C.

Lin28B promotes Müller glial cell de-differentiation and proliferation in the regenerative rat retinas

Science.gov (United States)

Tao, Zui; Zhao, Chen; Jian, Qian; Gillies, Mark; Xu, Haiwei; Yin, Zheng Qin

2016-01-01

Retinal regeneration and repair are severely impeded in higher mammalian animals. Although Müller cells can be activated and show some characteristics of progenitor cells when injured or under pathological conditions, they quickly form gliosis scars. Unfortunately, the basic mechanisms that impede retinal regeneration remain unknown. We studied retinas from Royal College of Surgeon (RCS) rats and found that let-7 family molecules, let-7e and let-7i, were significantly overexpressed in Müller cells of degenerative retinas. It demonstrated that down-regulation of the RNA binding protein Lin28B was one of the key factors leading to the overexpression of let-7e and let-7i. Lin28B ectopic expression in the Müller cells suppressed overexpression of let-7e and let-7i, stimulated and mobilized Müller glia de-differentiation, proliferation, promoted neuronal commitment, and inhibited glial fate acquisition of de-differentiated Müller cells. ERG recordings revealed that the amplitudes of a-wave and b-wave were improved significantly after Lin28B was delivered into the subretinal space of RCS rats. In summary, down-regulation of Lin28B as well as up-regulation of let-7e and let-7i may be the main factors that impede Müller cell de-differentiation and proliferation in the retina of RCS rats. PMID:27384999

Special Workshop of Marie Curie Fellows on Research and Training in Physics and Technology

CERN Multimedia

Patrice Loiez

2002-01-01

Photo 0210004_1: Prof. Ugo Amaldi, University of Milano Bicocca and Tera Foundation, Italy. Addressing the Marie Curie Workshop held at CERN 3-4 October 2002. Title of this talk:"Research Developments on Medical Physics". Photo 0210004_2: Marie Curie Fellows at CERN. Participating in Marie Curie Workshop held at CERN 3-4 October 2002.

'BRS Mari': nova cultivar de pimenta dedo-de-moça para processamento 'BRS Mari': new hot pepper cultivar for processing

Directory of Open Access Journals (Sweden)

Sabrina Isabel C de Carvalho

2009-12-01

Full Text Available 'BRS Mari' é uma nova cultivar de pimenta dedo-de-moça desenvolvida para uso múltiplo, como produto in natura, processada na forma de molho líquido ou desidratada em flocos, moída junto com as sementes, para a produção de pimenta tipo 'calabresa'. A cv. 'BRS Mari' foi desenvolvida a partir da população 'CNPH 0039' por meio de seis ciclos de seleção massal com autofecundação controlada. A nova cultivar apresenta plantas de polinização aberta com hábito de crescimento intermediário, com aproximadamente 90 cm de altura e 1,25 m de largura, com resistência múltipla a doenças, com destaque para o virus Pepper Yellow Mosaic Virus (PepYMV e nematóide das galhas (Meloidogyne javanica, resistência mediana ao oídio (Oidium sicula, mancha bacteriana (Xanthomonas spp. e antracnose (Colletotrichum spp.. A colheita dos frutos tem início cerca de 70 dias após o transplante. Nas condições da região Centro-Oeste, 'BRS Mari' apresentou boa uniformidade de planta, ótima qualidade de fruto e grande potencial produtivo, alcançando 35 t ha-1 em seis meses, quando cultivada no espaçamento de 1 m entre plantas e 1,5 m entre linhas. Os frutos são alongados e pendentes, típicos do tipo dedo-de-moça, com passagem de coloração verde claro, amarelo com antocianina e laranja quando imaturos e vermelho intenso quando maduros, com aproximadamente 6,0 cm de comprimento, 1,4 cm de largura e cerca de 1,7 mm de espessura da parede. A principal característica da 'BRS Mari' é o elevado teor de capsaicina, aproximadamente 90.000 SHU (Unidades de Calor Scoville, mais elevado quando comparada com outras cultivares do mesmo grupo.'BRS Mari' is a new hot pepper cultivar suitable for processing as sauce or dehydrated flakes, ordinarily known in Brazil as 'calabresa' type, as well as for fresh market. Hot pepper cv. 'BRS Mari' was obtained from population 'CNPH 0039', through six cycles of mass selection with controlled selfing of selected plants. The

Bon appetite! / Mari-Liis Rebane

Index Scriptorium Estoniae

Rebane, Mari-Liis

2009-01-01

Pimedate Ööde 13. filmifestivali alafestivali Animated Dreams täispikki animafilme: Austraalia "Mary ja Max" (režissöör Elliot, Adam), Rootsi-Taani-Norra "Metropia" (režissöör Tarik Saleh), Iisraeli-Austraalia "9,99 dollarit" (režissöör Tatia Rosenthal)

A role for the malignant brain tumour (MBT domain protein LIN-61 in DNA double-strand break repair by homologous recombination.

Directory of Open Access Journals (Sweden)

Nicholas M Johnson

Full Text Available Malignant brain tumour (MBT domain proteins are transcriptional repressors that function within Polycomb complexes. Some MBT genes are tumour suppressors, but how they prevent tumourigenesis is unknown. The Caenorhabditis elegans MBT protein LIN-61 is a member of the synMuvB chromatin-remodelling proteins that control vulval development. Here we report a new role for LIN-61: it protects the genome by promoting homologous recombination (HR for the repair of DNA double-strand breaks (DSBs. lin-61 mutants manifest numerous problems associated with defective HR in germ and somatic cells but remain proficient in meiotic recombination. They are hypersensitive to ionizing radiation and interstrand crosslinks but not UV light. Using a novel reporter system that monitors repair of a defined DSB in C. elegans somatic cells, we show that LIN-61 contributes to HR. The involvement of this MBT protein in HR raises the possibility that MBT-deficient tumours may also have defective DSB repair.

ANDRA - National Radioactive Waste Management Agency. Activity report 2007. Management report - Financial statements at December 31, 2007

International Nuclear Information System (INIS)

2008-09-01

Created in 1979 within the CEA, the National Radioactive Waste Management Agency (ANDRA) was established by the December 1991 Waste Act as a public body in charge of the long-term management of all radioactive waste, under the supervision of the Ministry of Ecology, Energy, Sustainable Development and the Sea (formerly the Ministry of Industry and the Ministry of Environment), and the Ministry of Research. Its 3 basic missions were extended and their funding secured through the 2006 Planning Act: - a R and D mission to propose safe long-term solution for radioactive waste without current disposal system; this mission includes long-term storage, since the 2006 Planning Act, in order to propose interim solutions while final ones are being studied; - an industrial mission concerning, on one hand, waste acceptance criteria and control and, on the other hand, siting, construction, operation, closure and monitoring of repositories. This mission includes as well a public service mission in terms of i) collection of waste of the 'small-scale nuclear activities' producers or owners (including the so-called 'household' radioactive waste, i.e. waste owned by private individuals) and ii) clean-up and rehabilitation of orphan polluted sites; - an information mission, notably through the regular publication of the National Inventory of radioactive materials and waste. This mission includes as well an active policy of dialogue with stakeholders both at national and local level. This document is the activity report with the management and financial statements report of the Andra for the year 2007

Rosie Carpe and the Virgin Mary: Modelling Modern Motherhood

Directory of Open Access Journals (Sweden)

Pauline Eaton

2016-06-01

Full Text Available Marie NDiaye’s 2001 novel, Rosie Carpe, incorporates, as one of its several instances of parenting failure, the narrative of the decline of a single mother from adequacy to abuse. This narrative, which is the focus of this article, might be said to put flesh on the bones of Julia Kristeva’s deconstruction of the Virgin Mary in her 1980s essay ‘Stabat Mater’. Kristeva saw the Marian model as out of date but she interrogated its enduring power and its continuing influence on our cultural perceptions of maternity. NDiaye’s eponymous Rosie realises she is pregnant but has no idea how this has come about. Rosie is not represented as a woman who has a religious faith but she decides to accept her child as a holy miracle. This article analyses how the ‘mythology’ of the Virgin Mary, and other biblical intertext, is woven into the narrative of Rosie’s experience of motherhood, so as to counterpoint and illuminate Rosie’s bleak and raw inner experience of maternity, an experience which, while confirming that Rosie is not, and never could have been, a modern Virgin Mary nevertheless refreshes the human stories at the root of the Christian narrative.

2006-2009: 4 years of research at the ANDRA for storage projects

International Nuclear Information System (INIS)

2010-01-01

This report gives an overview of research activities performed by the ANDRA (Agence nationale pour la gestion des dechets radioactifs, the French national agency for the management of radioactive wastes). These activities concern several axis: the consolidation of previously obtained data and the performance of long duration experimentations to support modelling studies, technological tests and implementation of storage control and survey means, a more precise assessment of safety margins through a finer assessment of the behaviour and evolution of the storage and of its components, development of numerical simulations, and the definition of a precise location for a possible storage. These activities are here reported according to different themes: storage reversibility as it is perceived by social and human sciences, conceptualisation of the geological media and of the associated biosphere, storage and its interactions with the environment, transfer phenomena within a storage, survey and control of a storage and of its environment, storage performance assessment, publications and scientific valuation

Klassika & ekskremendid / Mari Sobolev

Index Scriptorium Estoniae

Sobolev, Mari, 1968-

2002-01-01

20.-21. aprillil toimus Pärnus 8. Fideo- ja Vilmifestival alapealkirjaga "Eksperimendid ja klassika". Peakorraldaja Rael Artel. Rami Raski filmist "Legowitz 1999" (soome rühmitus Vivid), läti filmist "Love, death & television", Concordia ülikooli ("Ülemus") ja Academia Grata (portreefilmid Asta Isakist, Andrus Joonasest jm.) programmist, Kadriann Kibuse ja Liina Paakspuu filmist "Urban Obsessions", Mirja-Mari Smidti ja Allan Tõnissoo videost, Marianne Männi koomiksitest kataloogis

Cryptanalysis of Lin et al.'s Efficient Block-Cipher-Based Hash Function

NARCIS (Netherlands)

Liu, Bozhong; Gong, Zheng; Chen, Xiaohong; Qiu, Weidong; Zheng, Dong

2010-01-01

Hash functions are widely used in authentication. In this paper, the security of Lin et al.'s efficient block-cipher-based hash function is reviewed. By using Joux's multicollisions and Kelsey et al.'s expandable message techniques, we find the scheme is vulnerable to collision, preimage and second

Single-tube linear DNA amplification (LinDA) for robust ChIP-seq

NARCIS (Netherlands)

Shankaranarayanan, P.; Mendoza-Parra, M.A.; Walia, M.; Wang, L.; Li, N.; Trindade, L.M.; Gronemeyer, H.

2011-01-01

Genome-wide profiling of transcription factors based on massive parallel sequencing of immunoprecipitated chromatin (ChIP-seq) requires nanogram amounts of DNA. Here we describe a high-fidelity, single-tube linear DNA amplification method (LinDA) for ChIP-seq and reChIP-seq with picogram DNA amounts

The Mesoscale Science of the Matter-Radiation Interactions in Extremes (MaRIE) project

Energy Technology Data Exchange (ETDEWEB)

Kippen, Karen Elizabeth [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Montoya, Donald Raymond [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

2017-08-17

The National Nuclear Security Administration (NNSA) requires the ability to understand and test how material structures, defects, and interfaces determine performance in extreme environments such as in nuclear weapons. To do this, MaRIE will be an x-ray source that is laser-like and brilliant with very fl exible and fast pulses to see at weapons-relevant time scales, and with high enough energy to study critical materials. The Department of Energy (DOE) has determined there is a mission need for MaRIE to deliver this capability. MaRIE can use some of the existing infrastructure of the Los Alamos Neutron Science Center (LANSCE) and its accelerator capability. MaRIE will be built as a strategic partnership of DOE national laboratories and university collaborators.

Trans-Colonial Collaboration and Slave Narrative: Mary Prince Revisited

Directory of Open Access Journals (Sweden)

Michelle Gadpaille

2011-10-01

Full Text Available In 1831 in London, two formidable women met: Mary Prince, an ex-slave from Bermuda, who had crossed the Atlantic to a qualified freedom, and Susanna Strickland, an English writer. The narrative that emerged from this meeting was The History of Mary Prince, which played a role in the fight for slave emancipation in the British Empire. Prince disappeared once the battle was won, while Strickland emigrated to Upper Canada and, as Susanna Moodie, became an often quoted 19th century Canadian writer. Prince dictated, Strickland copied, and the whole was lightly edited by Thomas Pringle, the anti-slavery publisher at whose house the meeting took place. This is the standard account. In contesting this version, the paper aims to reinstate Moodie as co-creator of the collaborative Mary Prince text by considering multiple accounts of the meeting with Prince and to place the work in the context of Moodie’s pre- and post-emigration oeuvre on both sides of the Atlantic.

Causes of Charcot-Marie-Tooth Disease (CMT)

Science.gov (United States)

... Marie-Tooth Disease (CMT) Congenital Muscular Dystrophy (CMD) Duchenne Muscular Dystrophy (DMD) Emery-Dreifuss Muscular Dystrophy Endocrine Myopathies Metabolic Diseases of Muscle Mitochondrial Myopathies (MM) Myotonic Dystrophy (DM) Spinal-Bulbar ...

Mary Somerville and the world of science

CERN Document Server

Chapman, Allan

2015-01-01

Mary Somerville (1780-1872), after whom Somerville College Oxford was named, was the first woman scientist to win an international reputation entirely in her own right, rather than through association with a scientific brother or father. She was active in astronomy, one of the most demanding areas of science of the day, and flourished in the unique British tradition of Grand Amateurs, who paid their own way and were not affiliated with any academic institution. Mary Somerville was to science what Jane Austen was to literature and Frances Trollope to travel writing. Allan Chapman’s vivid account brings to light the story of an exceptional woman, whose achievements in a field dominated by men deserve to be very widely known.

Radikaalsus muuseumi kaitsva teki all / Mari Sobolev

Index Scriptorium Estoniae

Sobolev, Mari, 1968-

2004-01-01

Rotermanni soolalaos avatud Marco (Marko) Laimre isiknäituse "Küsimused ja vastused" puhul 13. IV toimunud konverentsist. Johannes Saare, Eha Komissarovi, Hanno Soansi, Anders Härmi ja Mari Sobolevi ettekannetest

Request by the Bure (Haute-Marne) CLIS related to the reading of well logging performed by the ANDRA from drilling located around Bure, to check rock characterization and properties. Report made by the ANCCLI's Scientific Committee

International Nuclear Information System (INIS)

2006-01-01

After having recalled the first conclusions of a work group built up by the Scientific Committee at the request of the Bure CLIS to assess studies performed by the ANDRA regarding the geological properties of the Bure site (site of deep geological storage of long life and high level radio-elements), this report proposes a critical discussion of measurements performed by the ANDRA, and more particularly of methodological aspects of this assessment of rock characteristics and properties based on well logging data. Thus, it comments the available raw data, the used instrumentation, the assessment of clay containment capacities (containment horizon homogeneity, stability of petrophysical properties, hydraulic studies with a focus on a noticed overpressure, modelling and data integration). Some brief propositions are stated. The appendix contains a set a questions to be submitted to the ANDRA by the Bure CLIS on the available data, on data calibration and homogenization, and on the assessment of containment capacities

On the Turn of Two Millennia (60 Years of the Mari Archaeological Expedition

Directory of Open Access Journals (Sweden)

Nikitin Valeriy V.,

2017-03-01

Full Text Available The article is dedicated to the 60th Anniversary of the Mari Archaeological Expedition and summarizes the two decades of its studies (1996-2016 into the early cultures of the Mari region, starting from the era of the original settlement (Mesolithic, through the Neolithic-Eneolithic, Bronze Age, Early Iron Age and up to the Middle Ages. The expedition studied stations and settlements of primitive cultures, as well as unfortified and fortified settlements and necropolises. Special studies focused on formation and development of the early Mari culture, as well as the material and spiritual culture of the medieval Mari. The expedition continues its survey exploration in order to identify new archaeological sites. During the reported period, twelve monographs were published and three monographs prepared based on the expedition’s materials.

The gga-let-7 family post-transcriptionally regulates TGFBR1 and LIN28B during the differentiation process in early chick development.

Science.gov (United States)

Lee, Sang In; Jeon, Mi-Hyang; Kim, Jeom Sun; Jeon, Ik-Soo; Byun, Sung June

2015-12-01

Early chick embryogenesis is governed by a complex mechanism involving transcriptional and post-transcriptional regulation, although how post-transcriptional processes influence the balance between pluripotency and differentiation during early chick development have not been previously investigated. Here, we characterized the microRNA (miRNA) signature associated with differentiation in the chick embryo, and found that as expression of the gga-let-7 family increases through early development, expression of their direct targets, TGFBR1 and LIN28B, decreases; indeed, gga-let-7a-5p and gga-let-7b miRNAs directly bind to TGFBR1 and LIN28B transcripts. Our data further indicate that TGFBR1 and LIN28B maintain pluripotency by regulating POUV, NANOG, and CRIPTO. Therefore, gga-let-7 miRNAs act as post-transcriptional regulators of differentiation in blastodermal cells by repressing the expression of the TGFBR1 and LIN28B, which intrinsically controls blastodermal cell differentiation in early chick development. © 2015 Wiley Periodicals, Inc.

Curcumin Inhibits LIN-28A through the Activation of miRNA-98 in the Lung Cancer Cell Line A549.

Science.gov (United States)

Liu, Wei-Lun; Chang, Jia-Ming; Chong, Inn-Wen; Hung, Yi-Li; Chen, Yung-Hsiang; Huang, Wen-Tsung; Kuo, Hsuan-Fu; Hsieh, Chong-Chao; Liu, Po-Len

2017-06-03

Metastasis is common in lung cancer and is associated with poor clinical outcomes and increased mortality. Curcumin is a natural anti-cancer agent that inhibits the metastasis of various cancers by modulating the expression of micro (mi) RNAs such as miR-98, which acts as a tumor suppressor. This study investigated the effect of curcumin on miR-98 expression and in vitro cell line growth and invasiveness in lung cancer. Curcumin treatment enhanced the expression of miR-98 and reduced that of the miR-98 target gene LIN28A as well as matrix metalloproteinase ( MMP ) 2 and MMP9 in vitro and in vivo. MiR-98 overexpression suppressed lung cancer cell migration and invasion by inhibiting LIN28A-induced MMP2 and MMP9 expression. Meanwhile, LIN28A level was downregulated by overexpression of miR-98 mimic. Induction of miR-98 by curcumin treatment suppressed MMP2 and MMP9 by targeting LIN28A. These findings provide insight into the mechanisms by which curcumin suppresses lung cancer cell line growth in vitro and in vivo and invasiveness in vitro.

Leadership, Longevity, and Leaning In: An Interview With Mary Jo (Joey) Bulfin.

Science.gov (United States)

Prestia, Angela S

2018-06-01

This column profiles Mary Jo Bulfin, MBA, RN, CENP, chief executive officer of St. Mary's Medical Center, West Palm Beach, Florida. Ms Bulfin began her career as a staff nurse in the organization where she is now the CEO and discusses her career path and lessons learned.

Esther Schor, ed. The Cambridge Companion to Mary Shelley

Directory of Open Access Journals (Sweden)

Anne BERTON

2006-06-01

Full Text Available “Today, whether she is found between staid cloth covers, in paperback, on the screen or in cyberspace, Mary Shelley is everywhere,” writes Esther Schor in her Introduction to this collection of essays (2. Interest in “the Author of Frankenstein” and of other works has grown steadily over the last twenty years, thanks notably to the publication of her Journals (The Journals of Mary Shelley, 1814-1844, ed. Paula R. Feldman and Diana Scott-Kilvert, 2 vols, Oxford: Clarendon, 1987, of her Lette...

An Effective Implementation of K-opt Moves for the Lin-Kernighan TSP Heuristic

DEFF Research Database (Denmark)

Helsgaun, Keld

Local search with k-change neighborhoods, k-opt, is the most widely used heuristic method for the traveling salesman problem (TSP). This report presents an effective implementation of k-opt for the Lin- Kernighan TSP heuristic. The effectiveness of the implementation is demonstrated with extensive...

Navodnenija v umah zactroishtshikov / Maris Kuuda

Index Scriptorium Estoniae

Kuuda, Maris

2007-01-01

Kohalikel omavalitsustel pole piisavalt hoobasid sundida arendajaid üleujutusohuga arvestama. Pärnusse hotelli September rajajad (arhitektid Emil Urbel, Andrus Mark) arvestavad ujutusohuga. Arvamust avaldavad Rene Reisner, Mari Sepp, Ülo Sults, Karri Tiigisoon, Indrek Rannik, Mark Soosaar, Tiiu Pärn, Merle Looring, Rita Sepp, Kaspar Alles

Charcot-Marie-Tooth disease.

LENUS (Irish Health Repository)

Reilly, Mary M

2011-03-01

Charcot-Marie-Tooth (CMT) disease is the commonest inherited neuromuscular disorder affecting at least 1 in 2,500. Over the last two decades, there have been rapid advances in understanding the molecular basis for many forms of CMT with more than 30 causative genes now described. This has made obtaining an accurate genetic diagnosis possible but at times challenging for clinicians. This review aims to provide a simple, pragmatic approach to diagnosing CMT from a clinician\\'s perspective.

Weak activity of haloalkane dehalogenase LinB with 1,2,3-trichloropropane revealed by X-Ray crystallography and microcalorimetry.

Science.gov (United States)

Monincová, Marta; Prokop, Zbynek; Vévodová, Jitka; Nagata, Yuji; Damborsky, Jirí

2007-03-01

1,2,3-Trichloropropane (TCP) is a highly toxic and recalcitrant compound. Haloalkane dehalogenases are bacterial enzymes that catalyze the cleavage of a carbon-halogen bond in a wide range of organic halogenated compounds. Haloalkane dehalogenase LinB from Sphingobium japonicum UT26 has, for a long time, been considered inactive with TCP, since the reaction cannot be easily detected by conventional analytical methods. Here we demonstrate detection of the weak activity (k(cat) = 0.005 s(-1)) of LinB with TCP using X-ray crystallography and microcalorimetry. This observation makes LinB a useful starting material for the development of a new biocatalyst toward TCP by protein engineering. Microcalorimetry is proposed to be a universal method for the detection of weak enzymatic activities. Detection of these activities is becoming increasingly important for engineering novel biocatalysts using the scaffolds of proteins with promiscuous activities.

Weak Activity of Haloalkane Dehalogenase LinB with 1,2,3-Trichloropropane Revealed by X-Ray Crystallography and Microcalorimetry▿

Science.gov (United States)

Monincová, Marta; Prokop, Zbyněk; Vévodová, Jitka; Nagata, Yuji; Damborský, Jiří

2007-01-01

1,2,3-Trichloropropane (TCP) is a highly toxic and recalcitrant compound. Haloalkane dehalogenases are bacterial enzymes that catalyze the cleavage of a carbon-halogen bond in a wide range of organic halogenated compounds. Haloalkane dehalogenase LinB from Sphingobium japonicum UT26 has, for a long time, been considered inactive with TCP, since the reaction cannot be easily detected by conventional analytical methods. Here we demonstrate detection of the weak activity (kcat = 0.005 s−1) of LinB with TCP using X-ray crystallography and microcalorimetry. This observation makes LinB a useful starting material for the development of a new biocatalyst toward TCP by protein engineering. Microcalorimetry is proposed to be a universal method for the detection of weak enzymatic activities. Detection of these activities is becoming increasingly important for engineering novel biocatalysts using the scaffolds of proteins with promiscuous activities. PMID:17259360

Special Workshop of Marie Curie Fellows on Research and Training in Physics and Technology.

CERN Multimedia

Patrice Loiez

2002-01-01

Photo 0210008_05a: Dr, Rolf Landua (CERN) explaining to participants of the Marie Curie Workshop (held at CERN 3-4 October 2002) the ATHENA experiment and the Antiproton Decelerator. Photo 0210008_06a: Dr, Rolf Landua (CERN) explaining to participants of the Marie Curie Workshop (held at CERN 3-4 October 2002) the ATHENA experiment and the Antiproton Decelerator. Photo 0210008_08a: Dr, Rolf Landua (CERN) explaining to participants of the Marie Curie Workshop (held at CERN 3-4 October 2002) the ATHENA experiment and the Antiproton Decelerator. Photo 0210008_09a: Dr, Rolf Landua (CERN) explaining to participants of the Marie Curie Workshop (held at CERN 3-4 October 2002) the ATHENA experiment and the Antiproton Decelerator.

LIN28B polymorphisms are associated with central precocious puberty and early puberty in girls

Directory of Open Access Journals (Sweden)

Sung Won Park

2012-10-01

Full Text Available &lt;B&gt;Purpose:&lt;/B&gt; Single-nucleotide polymorphism (SNP markers within &lt;i&gt;LIN28B&lt;/i&gt; have been reported to be related to the timing of pubertal growth. However, no study has investigated the frequency of genetic markers in girls with precocious puberty (PP or early puberty (EP. This study aimed to determine the frequency of putative genetic markers in girls with PP or EP. &lt;B&gt;Methods:&lt;/B&gt; Genomic DNAs were obtained from 77 and 109 girls that fulfilled the criteria for PP and EP, respectively. The controls in this study were 144 healthy volunteers between 20 and 30 years of age. The haplotypes were reconstructed using 11 SNPs of &lt;i&gt;LIN28B&lt;/i&gt;, and haplotype association analysis was performed. The haplotype frequencies were compared. Differences in the clinical and laboratory parameters were analyzed according to the haplotype dosage. &lt;B&gt;Results:&lt;/B&gt; Eleven SNPs in &lt;i&gt;LIN28B&lt;/i&gt; were all located in a block that was in linkage disequilibrium. The haplotype could be reconstructed using 2 representative SNPs, rs4946651 and rs369065. The AC haplotype was less frequently observed in the PP group than in the controls (0.069 vs. 0.144, &lt;I&gt;P&lt;/I&gt;=0.010. The trend that girls with non-AC haplotypes tended to have earlier puberty onset (&lt;I&gt;P&lt;/I&gt;=0.037 was illustrated even in the EP+PP patient group by Kaplan-Meier analysis. &lt;B&gt;Conclusion:&lt;/B&gt; The results of the present study showed that non-AC haplotypes of &lt;i&gt;LIN28B&lt;/i&gt;had a significant association with PP in girls.

A different voice: Mary Hays's the Memoirs of Emma Courtney.

Science.gov (United States)

Sharma, A

2001-01-01

Mary Hays wrote in the decade of the 1790s, a period of intense creative flowering in England. Writing in a period enshrined to the works of the canonical Wordsworth and Coleridge, Hays explored through her Jacobinical novel, The Memoirs of Emma Courtney, the contentious relationship between self and society. Like other Jacobin women writers - Elizabeth Inchbald, Charlotte Smith and Mary Wollstonecraft - Mary Hays too used her novel to explode the insidious connection between education and gender construction. Emma Courtney is a landmark novel that wrestles with the paradigm of decorum and propriety which disallows women from voicing their aspirations. In the process, Hays merges the plots of the domestic novel of courtship and love with the novel of ideas to create a searing portrait of women's intellectual confinement and psychic dissonance in a society that only projects them in terms of their gender construction. Memoirs of Emma Courtney is a remarkable novel in its depiction of the emotional imbalance created by thwarted desire: intellectual and sexual.

Mary Catherine and Me: Building Cross-Cultural Relationships in "Post-Racial" America

Science.gov (United States)

Bruno, Holly Elissa

2009-01-01

In 1963, President Obama's parents could not have married legally in a number of states. Mary Catherine and the author graduated from Corning Free Academy in Corning, New York, in June 1963. The lessons they learned were wrenching: "Someone is going to get hurt." Doors that opened for the author slammed in Mary Catherine's face. Holding Mary…

Identificação diferencial de Rhodococcus equi e Dietzia maris em bubalinos Differential identification of Rhodococcus equi and Dietzia maris in buffaloes

Directory of Open Access Journals (Sweden)

L.R. Viana

2009-08-01

Full Text Available Foram analisados 24 isolados bacterianos oriundos de leite e pele de búfalas (Bubalus bubalis, os quais foram previamente identificados como Rhodococcus equi com o auxílio de fenotipia concisa. Testes fenotípicos complementares e ferramentas moleculares foram utilizados com o objetivo de caracterizar esses isolados, bem como diferenciá-los de outros microrganismos intimamente relacionados. Observaram-se três fenótipos distintos, porém a identificação dos isolados foi inconclusiva. Apenas um dos isolados foi comprovado como sendo R. equi com a realização da PCR espécie-específica, sequenciamento e análise dos fragmentos de DNA. Os demais isolados só foram identificados pelo sequenciamento de fragmento do gene que codifica a região 16S do rRNA universal de bactérias, indicando tratar-se de Dietzia maris. O perfil de susceptibilidade aos antimicrobianos revelou maior resistência dos isolados de D. maris para oxacilina (96% e rifampicina (87%. O isolado de R. equi apresentou resistência à amicacina, oxacilina, penicilina, rifampicina e tetraciclina. Alerta-se para o risco da incorreta identificação dos isolados baseados em testes fenotípicos concisos e para a necessidade de utilização de testes complementares para diferenciação entre R. equi e D. maris.Twenty-four bacterial isolates from milk and skin of buffalo females (Bubalus bubalis, which previously had been identified as Rhodococcus equi by using a restricted number of phenotypical tests for bacterial characterization, were analyzed. The goal of this study was to perform the characterization of these isolates, as well as the differentiation of other microorganisms closely related by using additional phenotypical tests and molecular tools. Based on the phenotypical results, three different biotypes were obtained. However, the identification of the isolates was inconclusive. Only one of the isolates was confirmed as R. equi by the PCR specifically for this species, as

Loss of the Caenorhabditis elegans pocket protein LIN-35 reveals MuvB's innate function as the repressor of DREAM target genes.

Directory of Open Access Journals (Sweden)

Paul D Goetsch

2017-11-01

Full Text Available The DREAM (Dp/Retinoblastoma(Rb-like/E2F/MuvB transcriptional repressor complex acts as a gatekeeper of the mammalian cell cycle by establishing and maintaining cellular quiescence. How DREAM's three functional components, the E2F-DP heterodimer, the Rb-like pocket protein, and the MuvB subcomplex, form and function at target gene promoters remains unknown. The current model invokes that the pocket protein links E2F-DP and MuvB and is essential for gene repression. We tested this model by assessing how the conserved yet less redundant DREAM system in Caenorhabditis elegans is affected by absence of the sole C. elegans pocket protein LIN-35. Using a LIN-35 protein null mutant, we analyzed the assembly of E2F-DP and MuvB at promoters that are bound by DREAM and the level of expression of those "DREAM target genes" in embryos. We report that LIN-35 indeed mediates the association of E2F-DP and MuvB, a function that stabilizes DREAM subunit occupancy at target genes. In the absence of LIN-35, the occupancy of E2F-DP and MuvB at most DREAM target genes decreases dramatically and many of those genes become upregulated. The retention of E2F-DP and MuvB at some target gene promoters in lin-35 null embryos allowed us to test their contribution to DREAM target gene repression. Depletion of MuvB, but not E2F-DP, in the sensitized lin-35 null background caused further upregulation of DREAM target genes. We conclude that the pocket protein functions primarily to support MuvB-mediated repression of DREAM targets and that transcriptional repression is the innate function of the evolutionarily conserved MuvB complex. Our findings provide important insights into how mammalian DREAM assembly and disassembly may regulate gene expression and the cell cycle.

Mary Abigail Dodge: Journalist & Anti-Feminist.

Science.gov (United States)

Beasley, Maurine

Mary Abigail Dodge, a Washington, D.C., correspondent before and after the United States Civil War, was one of the most acclaimed women journalists of the nineteenth century. Unknown today, Dodge wrote on politics, religion, and contemporary issues for newspapers and magazines and commented prolifically on the role of women in society. After…

The ANDRA, two years after the June 2006 28. programming law. Assessment and perspectives in Meuse/Haute-Marne. Press conference of June 2008, 12

International Nuclear Information System (INIS)

2008-01-01

This report first presents the main activities of ANDRA (the French national agency for radioactive waste management) in the studies for the development and construction of a high-activity and long-life waste storage site, and particularly for a project located in Meuse/Haute-Marne region, and more briefly for a low-activity and long-life waste storage (for graphite and radiferous wastes). It presents and comments the legal frame (programming law of June 2006, 28) which introduces a national plan for radioactive materials and wastes (PNGMDR) which is to be updated once every three years. Then, it describes ANDRA's missions, its role as industrial operator, its financing, and its certification level. It describes its general interest missions: national inventory of radioactive materials and wastes, collection and processing of common usage radioactive objects, and decontamination of sites polluted by radioactivity. It presents its project of reversible deep storage of high and intermediate level and long life wastes (a facility is foreseen to operate in 2025), the technology centre, the 'open doors day', and the project of a hollow storage site for low activity and long life wastes

TOURISM PLANNING OPPORTUNITIES FOR THE SALT LAKES OF OCNELE MARI AND OCNIŢA

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POPESCU ANTOANETA-CARINA

2012-03-01

Full Text Available Tourism Planning Opportunities for The Salt Lakes of Ocnele Mari and Ocniţa. Ocnele Mari used to be a popular balneal tourism destination in the Southern region of Romania, Oltenia. Due to the hilly climate and the two balneal establishments of Ocnele Mari and Ocniţa, tourists could find the necessary natural cure factors for rheumatic and cardiovascular diseases. However, the salt from Ocnele Mari was also used for industrial purposes, being extracted through solution mining, which proved to be detrimental to the environment. Salt underground dissolution caused land subsidence and landslide in the area, together with the formation of large salt lakes. Security became an issue, the number of tourists diminished and the balneal equipment became obsolete because of lack of modernization investment. Under these circumstances, on the basis of field work, we have reached the conclusion that a better planning of the resort and of the salt lakes would contribute to the economic development of the region.

Safety and Feasibility of Lin- Cells Administration to ALS Patients: A Novel View on Humoral Factors and miRNA Profiles

Directory of Open Access Journals (Sweden)

Anna Sobuś

2018-04-01

Full Text Available Therapeutic options for amyotrophic lateral sclerosis (ALS are still limited. Great hopes, however, are placed in growth factors that show neuroprotective abilities (e.g., nerve growth factor (NGF, brain-derived neurotrophic factor (BDNF, and vascular endothelial growth factor (VEGF and in the immune modulating features, in particular, the anti-inflammatory effects. In our study we aimed to investigate whether a bone marrow-derived lineage-negative (Lin- cells population, after autologous application into cerebrospinal fluid (CSF, is able to produce noticeable concentrations of trophic factors and inflammatory-related proteins and thus influence the clinical course of ALS. To our knowledge, the evaluation of Lin- cells transplantation for ALS treatment has not been previously reported. Early hematopoietic Lin- cells were isolated from twelve ALS patients’ bone marrow, and later, the suspension of cells was administered into the subarachnoid space by lumbar puncture. Concentrations of selected proteins in the CSF and plasma were quantified by multiplex fluorescent bead-based immunoassays at different timepoints post-transplantation. We also chose microRNAs (miRNAs related to muscle biology (miRNA-1, miRNA-133a, and miRNA-206 and angiogenesis and inflammation (miRNA-155 and miRNA-378 and tested, for the first time, their expression profiles in the CSF and plasma of ALS patients after Lin- cells transplantation. The injection of bone marrow cells resulted in decreased concentration of selected inflammatory proteins (C3 after Lin- cells injection, particularly in patients who had a better clinical outcome. Moreover, several analyzed miRNAs have changed expression levels in the CSF and plasma of ALS patients subsequent to Lin- cells administration. Interestingly, the expression of miR-206 increased in ALS patients, while miR-378 decreased both in the CSF and plasma one month after the cells’ injection. We propose that autologous lineage

Safety and Feasibility of Lin- Cells Administration to ALS Patients: A Novel View on Humoral Factors and miRNA Profiles.

Science.gov (United States)

Sobuś, Anna; Baumert, Bartłomiej; Litwińska, Zofia; Gołąb-Janowska, Monika; Stępniewski, Jacek; Kotowski, Maciej; Pius-Sadowska, Ewa; Kawa, Miłosz P; Gródecka-Szwajkiewicz, Dorota; Peregud-Pogorzelski, Jarosław; Dulak, Józef; Nowacki, Przemysław; Machaliński, Bogusław

2018-04-27

Therapeutic options for amyotrophic lateral sclerosis (ALS) are still limited. Great hopes, however, are placed in growth factors that show neuroprotective abilities (e.g., nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and vascular endothelial growth factor (VEGF)) and in the immune modulating features, in particular, the anti-inflammatory effects. In our study we aimed to investigate whether a bone marrow-derived lineage-negative (Lin-) cells population, after autologous application into cerebrospinal fluid (CSF), is able to produce noticeable concentrations of trophic factors and inflammatory-related proteins and thus influence the clinical course of ALS. To our knowledge, the evaluation of Lin- cells transplantation for ALS treatment has not been previously reported. Early hematopoietic Lin- cells were isolated from twelve ALS patients’ bone marrow, and later, the suspension of cells was administered into the subarachnoid space by lumbar puncture. Concentrations of selected proteins in the CSF and plasma were quantified by multiplex fluorescent bead-based immunoassays at different timepoints post-transplantation. We also chose microRNAs (miRNAs) related to muscle biology (miRNA-1, miRNA-133a, and miRNA-206) and angiogenesis and inflammation (miRNA-155 and miRNA-378) and tested, for the first time, their expression profiles in the CSF and plasma of ALS patients after Lin- cells transplantation. The injection of bone marrow cells resulted in decreased concentration of selected inflammatory proteins (C3) after Lin- cells injection, particularly in patients who had a better clinical outcome. Moreover, several analyzed miRNAs have changed expression levels in the CSF and plasma of ALS patients subsequent to Lin- cells administration. Interestingly, the expression of miR-206 increased in ALS patients, while miR-378 decreased both in the CSF and plasma one month after the cells’ injection. We propose that autologous lineage-negative early

Chaos M-ary modulation and demodulation method based on Hamilton oscillator and its application in communication.

Science.gov (United States)

Fu, Yongqing; Li, Xingyuan; Li, Yanan; Yang, Wei; Song, Hailiang

2013-03-01

Chaotic communication has aroused general interests in recent years, but its communication effect is not ideal with the restriction of chaos synchronization. In this paper a new chaos M-ary digital modulation and demodulation method is proposed. By using region controllable characteristics of spatiotemporal chaos Hamilton map in phase plane and chaos unique characteristic, which is sensitive to initial value, zone mapping method is proposed. It establishes the map relationship between M-ary digital information and the region of Hamilton map phase plane, thus the M-ary information chaos modulation is realized. In addition, zone partition demodulation method is proposed based on the structure characteristic of Hamilton modulated information, which separates M-ary information from phase trajectory of chaotic Hamilton map, and the theory analysis of zone partition demodulator's boundary range is given. Finally, the communication system based on the two methods is constructed on the personal computer. The simulation shows that in high speed transmission communications and with no chaos synchronization circumstance, the proposed chaotic M-ary modulation and demodulation method has outperformed some conventional M-ary modulation methods, such as quadrature phase shift keying and M-ary pulse amplitude modulation in bit error rate. Besides, it has performance improvement in bandwidth efficiency, transmission efficiency and anti-noise performance, and the system complexity is low and chaos signal is easy to generate.

Potential hosts for Lambertella corni-maris and Phacidium lacerum within the family Rosaceae

Science.gov (United States)

Two fungi were described in 2015 and 2016 as pathogens of pome fruit in the Pacific Northwest USA: Lambertella corni-maris on apple (Malus domestica), and Phacidium lacerum (synonym, Ceuthospora pinastri) on apple and d’Anjou pear (Pyrus communis). We documented pathogenicity of L. corni-maris to d...

ANDRA - National Radioactive Waste Management Agency. Annual sustainable development and activity report 2011. Management report and financial statements 2011

International Nuclear Information System (INIS)

2012-01-01

Created in 1979 within the CEA, the National Radioactive Waste Management Agency (ANDRA) was established by the December 1991 Waste Act as a public body in charge of the long-term management of all radioactive waste, under the supervision of the Ministry of Ecology, Energy, Sustainable Development and the Sea (formerly the Ministry of Industry and the Ministry of Environment), and the Ministry of Research. Its 3 basic missions were extended and their funding secured through the 2006 Planning Act: - a R and D mission to propose safe long-term solution for radioactive waste without current disposal system; this mission includes long-term storage, since the 2006 Planning Act, in order to propose interim solutions while final ones are being studied; - an industrial mission concerning, on one hand, waste acceptance criteria and control and, on the other hand, siting, construction, operation, closure and monitoring of repositories. This mission includes as well a public service mission in terms of i) collection of waste of the 'small-scale nuclear activities' producers or owners (including the so-called 'household' radioactive waste, i.e. waste owned by private individuals) and ii) clean-up and rehabilitation of orphan polluted sites; - an information mission, notably through the regular publication of the National Inventory of radioactive materials and waste. This mission includes as well an active policy of dialogue with stakeholders both at national and local level. This document is the activity and Sustainable Development Report, with the management and financial statements report, of the Andra for the year 2011

ANDRA - National Radioactive Waste Management Agency. Annual sustainable development and activity report 2012. Management report and financial statements 2012

International Nuclear Information System (INIS)

2013-01-01

Created in 1979 within the CEA, the National Radioactive Waste Management Agency (ANDRA) was established by the December 1991 Waste Act as a public body in charge of the long-term management of all radioactive waste, under the supervision of the Ministry of Ecology, Energy, Sustainable Development and the Sea (formerly the Ministry of Industry and the Ministry of Environment), and the Ministry of Research. Its 3 basic missions were extended and their funding secured through the 2006 Planning Act: - a R and D mission to propose safe long-term solution for radioactive waste without current disposal system; this mission includes long-term storage, since the 2006 Planning Act, in order to propose interim solutions while final ones are being studied; - an industrial mission concerning, on one hand, waste acceptance criteria and control and, on the other hand, siting, construction, operation, closure and monitoring of repositories. This mission includes as well a public service mission in terms of i) collection of waste of the 'small-scale nuclear activities' producers or owners (including the so-called 'household' radioactive waste, i.e. waste owned by private individuals) and ii) clean-up and rehabilitation of orphan polluted sites; - an information mission, notably through the regular publication of the National Inventory of radioactive materials and waste. This mission includes as well an active policy of dialogue with stakeholders both at national and local level. This document is the activity and Sustainable Development Report, with the management and financial statements report, of the Andra for the year 2012

"Inhumanly brought back to life and misery": Mary Wollstonecraft, Frankenstein, and the Royal Humane Society.

Science.gov (United States)

Williams, C

2001-01-01

While thorough investigation of many aspects of contemporary scientific developments and Mary Shelley's personal history have provided illuminating contexts for the study of Frankenstein, the activities of the Royal Humane Society, and other bodies and individuals who pioneered and publicized resuscitation techniques, have been comparatively neglected. Here we find a richly documented, highly conspicuous area of scientific endeavour, which generated much excitement in life and literature from the last quarter of the eighteenth century onwards. There are three major points of contact with Frankenstein: Victor Frankenstein's revival of dead tissue to make his creature; the frequent occurrences of unconsciousness and asphyxia, both in the novel and in Mary Shelley's family during the period leading up to its composition, and the widely differing degrees of competence and success with which they are treated; and the possibility that resuscitative techniques were used to revive Mary Shelley's mother, Mary Wollstonecraft, after a suicide attempt. The impact on Frankenstein of Mary Shelley's lifelong distress at the role she played in bringing about her mother's death in childbirth has been thoroughly canvassed by other critics, notably Anne Mellor, but the thought that Mary Shelley, who was herself conceived after her mother's second suicide attempt, might be, in a sense, a child of the dead adds a further turn to the Gothic screw. This study traces a hitherto unexplored intersection between Mary Shelley's first novel and her family history, as well as showing how it launches a formidable attack on the shady ethics and inconsiderate arrogance of some early resuscitators.

Aspectos históricos da visita de Marie Sklodowska Curie a Belo Horizonte

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Cássius Klay Nascimento

2011-01-01

Full Text Available In the year 2011 it is celebrated the Marie Sklodowska Curie Nobel Prize centenary and the International Year of Chemistry. However, it is not generally known that Marie Sklodowska Curie, one of the greatest scientists of all time, visited Belo Horizonte, state of Minas Gerais, Brazil. She arrived by train at Belo Horizonte city on 16 August 1926, coming from Rio de Janeiro and accompanied by her daughter Irène Joliot-Curie. The scientists visited the Institute of Radium of Belo Horizonte. The approach in this work emphasizes the presence of Marie Sklodowska Curie in Belo Horizonte, exploring the admiration and respect that people had for her.

‘Het witte spook van Mesdag’. De bruid van Matthijs Maris opnieuw bezien’

NARCIS (Netherlands)

Bionda, R.W.A.

2013-01-01

The Bride (1867-'68) by Matthijs Maris in The Mesdag Collection is without doubt one of his most intriguing early works. Though he defensively described it as only a 'sketch' which he could not bring to a satisfying end, Maris considered this fairly large piece as quite important. Regardless of its

75 FR 51945 - Safety Zone; Potomac River, St. Mary's River, St. Inigoes, MD

Science.gov (United States)

2010-08-24

...-AA00 Safety Zone; Potomac River, St. Mary's River, St. Inigoes, MD AGENCY: Coast Guard, DHS. ACTION... of the St. Mary's River, a tributary of the Potomac River. This action is necessary to provide for.... Navy helicopter located near St. Inigoes, Maryland. This safety zone is intended to protect the...

Friendship in the Life and Work of Mary Wollstonecraft: The Making of a Liberal Feminist Tradition

DEFF Research Database (Denmark)

Pedersen, Joyce Senders

2008-01-01

Mary Wollstonecrafts venskaber placeres indenfor en liberal fortolkningstradition . Udgivelsesdato: Spring 2008......Mary Wollstonecrafts venskaber placeres indenfor en liberal fortolkningstradition . Udgivelsesdato: Spring 2008...

The seminal role played by Pierre Marie in Neurology and Internal Medicine

Directory of Open Access Journals (Sweden)

Gustavo M Almeida

2015-10-01

Full Text Available The authors review the most important contributions of Pierre Marie to the elucidation and description of several neurological diseases, such as Charcot-Marie-Tooth’s disease and hereditary cerebellar ataxia, as well as his contributions to Internal Medicine, including his pioneering studies on acromegaly, ankylosing spondylitis, and hypertrophic pulmonary osteoarthropathy. His works led to incontestable advances in the medical sciences that transcended his time.

A bust of Marie Sklodowska Curie at CERN

CERN Multimedia

CERN PhotoLab

1979-01-01

The Polish Deputy Minister of Energy and Nuclear Power, J. Felicki, presented the Directors General with a bust of Mme Marie Sklodowska Curie on behalf of physicists of Poland (CERN Courier 19 (1979) 164).

Ämari baas sobib USA-le ja brittidele

Index Scriptorium Estoniae

2013-01-01

Eelmisel nädalal Eestit külastanud USA ja Ühendkuningriigi sõjalised esindajad NATO juures kindralleitnandid David R. Hogg ja Christopher Harper kinnitasid, et on valmis oma lennukeid Ämari baasist opereerima

Lin28a is a putative factor in regulating cancer stem cell-like properties in side population cells of oral squamous cell carcinoma

Energy Technology Data Exchange (ETDEWEB)

Hayashi, S.; Tanaka, J.; Okada, S.; Isobe, T.; Yamamoto, G.; Yasuhara, R.; Irie, T.; Akiyama, C.; Kohno, Y.; Tachikawa, T.; Mishima, K., E-mail: mishima-k@dent.showa-u.ac.jp

2013-05-01

Cancer stem cells (CSCs) are among the target cells of cancer therapy because they are uniquely involved in both cancer progression and sensitivity to chemotherapeutic agents. We identified side population (SP) cells, which are known to be an enriched population of CSC, in five oral squamous cell carcinoma (OSCC) cells (SCC9, SCC25, TOSCC7, TOSCC17, and TOSCC23). The percentages of SP cells ranged from 0% to 3.3%, with TOSCC23 cells showing the highest percentages of SP cells (3.3% of the total cell population). The SP cells isolated from TOSCC23 cells also showed greater cell proliferation and invasion compared to non-SP (MP) cells. Therefore, our initial findings suggested that SP cells were enriched for CSC-like cells. Furthermore, DNA microarray analysis revealed that the expression of cell proliferation-related and anti-apoptotic genes was greater in SP cells compared to MP cells. We focused on Lin28a, which showed the highest expression (approximately 22-fold) among the upregulated genes. The overexpression of Lin28a in TOSCC23 cells increased their proliferation, colony formation, and invasion. These findings suggest that Lin28a is an appropriate CSC target molecule for OSCC treatment - Highlights: ► Lin28a is a SP cell-specific factor in oral squamous cell carcinoma (OSCC) cells. ► SP cells in OSCC cells show cancer stem cell-like properties. ► Lin28a regulates OSCC proliferative and invasive activities.

Lin28a is a putative factor in regulating cancer stem cell-like properties in side population cells of oral squamous cell carcinoma

International Nuclear Information System (INIS)

Hayashi, S.; Tanaka, J.; Okada, S.; Isobe, T.; Yamamoto, G.; Yasuhara, R.; Irie, T.; Akiyama, C.; Kohno, Y.; Tachikawa, T.; Mishima, K.

2013-01-01

Cancer stem cells (CSCs) are among the target cells of cancer therapy because they are uniquely involved in both cancer progression and sensitivity to chemotherapeutic agents. We identified side population (SP) cells, which are known to be an enriched population of CSC, in five oral squamous cell carcinoma (OSCC) cells (SCC9, SCC25, TOSCC7, TOSCC17, and TOSCC23). The percentages of SP cells ranged from 0% to 3.3%, with TOSCC23 cells showing the highest percentages of SP cells (3.3% of the total cell population). The SP cells isolated from TOSCC23 cells also showed greater cell proliferation and invasion compared to non-SP (MP) cells. Therefore, our initial findings suggested that SP cells were enriched for CSC-like cells. Furthermore, DNA microarray analysis revealed that the expression of cell proliferation-related and anti-apoptotic genes was greater in SP cells compared to MP cells. We focused on Lin28a, which showed the highest expression (approximately 22-fold) among the upregulated genes. The overexpression of Lin28a in TOSCC23 cells increased their proliferation, colony formation, and invasion. These findings suggest that Lin28a is an appropriate CSC target molecule for OSCC treatment - Highlights: ► Lin28a is a SP cell-specific factor in oral squamous cell carcinoma (OSCC) cells. ► SP cells in OSCC cells show cancer stem cell-like properties. ► Lin28a regulates OSCC proliferative and invasive activities

Marie Sklodowska-Curie, polonium, radium and radiochemistry

International Nuclear Information System (INIS)

Guillaumont, R.

2011-01-01

In this work, the author describes how the methodology developed by Marie Curie in discovering polonium and radium has contributed to greater scientific discoveries and how these discoveries have played a great part in the development of science in general and have particularly enriched chemistry. (O.M.)

Põhja-Eesti Regionaalhaigla X-korpus = North-Estonian Regional Hospital X-wing / Mari Kurismaa ; intervjueerinud Margit Mutso

Index Scriptorium Estoniae

Kurismaa, Mari, 1956-

2011-01-01

Tallinnas Sütiste tee 19 asuva haigla juurdeehitise sisekujundusest. Sisearhitekt Mari Kurismaa (Stuudio Kurismaa OÜ). Arhitektid Indrek Suigusaar, Vivian Oruvee (AB Pluss OÜ). Infograafika autor Mari Kaljuste

ReUse Republic annab mõistele "uuskasutus" uue tähenduse / Tanel Veenre, Mari Klein

Index Scriptorium Estoniae

Veenre, Tanel, 1977-

2009-01-01

Moe- ja disainiagentuuri KalaMari uuest kaubamärgist ReUse Republic. Tegu on seisma jäänud brändirõivaste ümberdisainimise ja (uus)kasutusega. Projekti looja Mari Martin, kaasatud 15 eesti disainerit

Correlations between silicic volcanic rocks of the St Mary's Islands (southwestern India) and eastern Madagascar

DEFF Research Database (Denmark)

Melluso, Leone; Sheth, Hetu C.; Mahoney, John J.

2009-01-01

The St Mary's, Islands (southwestern India) expose silicic volcanic and sub-volcanic rocks (rhyolites and granophyric dacites) emplaced contemporaneously with the Cretaceous igneous province of Madagascar, roughly 88-90 Ma ago. I he St Mary's Islands rocks have phenocrysts of plagioclase...... and isotopic Compositions very close to those of rhyolites exposed between Vatomandry Ilaka and Mananjary in eastern Madagascar, and are distinctly different from rhyolites front other sectors of the Madagascan province. We therefore postulate that the St Mary's and the Vatomandry-Ilaka Mananjary silicic rock...

Long noncoding RNA TUG1 facilitates osteogenic differentiation of periodontal ligament stem cells via interacting with Lin28A.

Science.gov (United States)

He, Qin; Yang, Shuangyan; Gu, Xiuge; Li, Mengying; Wang, Chunling; Wei, Fulan

2018-04-19

Periodontal ligament stem cells (PDLSCs) are mesenchymal stem cells derived from dental tissues with multidirectional differentiation potential and excellent self-renewing ability. Recently, long noncoding RNAs (lncRNAs) have been shown to play important roles in MSC osteogenic differentiation. In this study, we found that taurine upregulated gene 1 (TUG1), an evolutionarily conserved and widely present lncRNA was significantly upregulated in osteogenically induced PDLSCs compared to their undifferentiated counterparts. Further investigation demonstrated that the expression of TUG1 was positively correlated with the osteogenic differentiation of PDLSCs following the induction, as evidenced by the increase in cellular alkaline phosphatase (ALP) level, formation of calcium nodules, and the upregulation of several osteogenic-related gene markers such as ALP, osteocalcin (OCN), and runt-related transcription factor 2 (Runx2). Conversely, TUG1 knockdown was demonstrated to inhibit the potential of PDLSCs for osteogenic differentiation. Using bioinformatics analysis, we identified lin-28 homolog A (Lin28A) as a potential target of TUG1 during osteogenic differentiation of PDLSCs. Lin28A was found to be significantly downregulated in TUG1-repressed PDLSCs and contained multiple binding sites for lncRNA TUG1. Moreover, suppression of Lin28A was shown to be able to inhibit osteogenic differentiation and decreased the expression of several osteogenic genes. Taken together, these results could help researchers better understand the mechanism that governs the osteogenic differentiation of PDLSCs, and also serve as a stepping stone for the development of novel therapeutic strategies that can be used to regenerate dental tissues.

The Marie Curie Actions at CERN – reaching out beyond particle physics and Europe

CERN Document Server

EU Projects Office

2014-01-01

The European Commission’s Marie Curie Actions have been a pillar of the EU Framework Programmes for several decades as a means of promoting career development and enhancing mobility of researchers in Europe. This corresponds nicely to one of CERN’s main missions: to train the next generation of scientists and engineers.   The European Commissioner for Education, Culture, Multilingualism, Sport, Media and Youth, Androulla Vassiliou (centre) met the Marie Curie Fellows on her visit to CERN in April 2013. CERN has been pleased to be a major player in the Marie Curie Actions under the Sixth and Seventh Framework Programmes (FP6 from 2002 to 2006 and FP7 from 2007 to 2013), being one of the most successful participants in Europe. Under FP7, CERN was ranked first in Switzerland and fifth in Europe against stiff competition in terms of overall funding. Participation was in all of the Marie Curie Actions: Initial Training Networks, Industry-Academia Partnership Pathways, IRSES, CO...

Naine : masin või loom? / Maris Palgi

Index Scriptorium Estoniae

Palgi, Maris

2007-01-01

Eero Taltsi, Margus Kiisi, Maia Mölleri, Kaie Luige, Eva Orava ja Maris Palgi projektist "Maine-loom, naine-masin", mida tutvustati 2006. a. Moostes üritusel "Postsovkhoz 6", 2007. a. jaanuaris-veebruaris Tartu Kunstimajas ja Tartu Tampere Majas. Näitused avati E. Taltsi ja M. Kiisi loeng-performance'itega

Mariátegui entre dois mundos: Visões do comunitarismo indígena andino

Directory of Open Access Journals (Sweden)

Cristhian Teófilo da Silva

2014-12-01

Full Text Available Resumo  Este artigo visa demonstrar que a presença da herança andina no projeto de socialismo “indo-americano” de Mariátegui gerou uma tensão epistemológica original e crítica do pensamento social marxista na América Latina. A partir desta releitura da perspectiva mariateguiana apoiada em duas vertentes, indigenista peruana e marxista europeia, o presente artigo afirma a importância dos estudos sobre o indigenismo para a compreensão dos limites do socialismo de orientação marxista no Peru. O artigo será concluído ressaltando a importância do socialismo indo-americano de Mariátegui para a “descoberta” da constituição híbrida do modo de produção peruano.  Palavras-chave  Indigenismo; marxismo; Peru; José Carlos Mariátegui  --- Resumen  Este artículo tiene como objetivo demostrar que la presencia de la herencia andina en el diseño del socialismo "indoamericano" de Mariátegui ha generado una crítica epistemológica original del pensamiento social marxista en América Latina. De este recuento la perspectiva de Mariátegui apoyada en dos frentes, indigenista peruana y marxista europea, este artículo defiende la importancia de los estudios sobre el indigenismo para la comprensión de los límites del socialismo marxista en el Perú. El artículo concluirá destacando la importancia del socialismo indo-americano de Mariátegui en el "descubrimiento" de la constitución híbrida del modo de producción peruana.  Palabras clave  Indigenismo; marxismo; Perú; José Carlos Mariátegui --- Abstract This article aims to demonstrate that the presence of the Andean heritage in Mariátegui's "Indo-American" socialist project generated a new and critical epistemological tension of the Marxist social thinking in Latin America. From this mariateguian retelling, which is established in two ways, Peruvian indigenous and European Marxist, this article maintains the importance of studies on the indigenous movement to understand

Igal mõisal on oma lugu / Mari-Ann Remmel

Index Scriptorium Estoniae

Remmel, Mari-Ann

2008-01-01

Kirjastuselt "Tänapäev" ilmus raamat "Mõisalegendid. Harjumaa", koostaja Mari-Ann Remmel, kujundaja Angelika Schneider. Kogumik sisaldab ka ajaloolist ning genealoogilist teavet mõisahoonete ning -omanike kohta

Eesti NATO ukselävel / Mari-Ann Kelam

Index Scriptorium Estoniae

Kelam, Mari-Ann, 1946-

2002-01-01

Seda, et NATO liitumisläbirääkimistele kutsutavate seas on ka Eesti, saab veel tänagi pidada üheks meie iseseisva riikluse suursaavutuseks, kui mitte imeks, kirjutab Riigikogu liige Mari-Ann Kelam. Autor: Isamaaliit. Parlamendisaadik

Mary Shelley's Frankenstein: what made the Monster monstrous?

Science.gov (United States)

Britton, Ronald

2015-02-01

This paper discusses the genesis of the famous story of Frankenstein which arose from a dream experienced by Mary Shelley whilst on a holiday shared with her husband Percy Shelley, Lord Byron, Dr Polidori and her step sister Claire Clairmont. The novel relates how the creature created by Victor Frankenstein horrifies him, is rejected by him and called a monster. The monster's ensuing despair and subsequent murderousness is eloquently described. The whole book is clearly connected to Mary Shelley's experience as an infant whose mother died after giving birth to her and her subsequent loss, as a mother, of her own new born infant. It is suggested that the novel imaginatively describes what it is to have been primarily rejected as an infant and to feel regarded as a monster. © 2015, The Society of Analytical Psychology.

Näitused / Mari Sobolev

Index Scriptorium Estoniae

Sobolev, Mari, 1968-

1998-01-01

Rotermanni soolaladu. "Elektrokardiogramm" (tegevuskunsti üritus); Vaal-galerii. Antoni T̉pies "Litograafiaid aastatest 1973-1995"; Mari Kadanik, Eero Barndõk, Rain Ader "Pildid" (maalid); Paldiski Põhikool. "Niemenlautta ja Hugo Simbergi fotod" (soome kunstniku fotode koopiad, pildistatud enne 1915. a.; Kullo lastegalerii. Neli uut näitust.(lastekunst); Arhitektuurimuuseum. Arnold Matteus - Tartu linna arhitekt (juubelinäitus), Alvar Aalto "Kolm objekti Eestis"; Linnagalerii Tallinnas. "Valge" (ruumi- ja moekunsti näitus); Sammas-galerii. Jüri Jegorow "Insect" (arvutigraafika); Endla Teatri palmisaal. "Muzik in der Kunst" (Tallinna kunstitudengite näitus); Eesti Rahvusraamatukogu. Õie Kütt "Uued ja vanad ehted"

Mary Bidwell Breed: The Educator as Dean.

Science.gov (United States)

Fley, Jo Ann; Jaramillo, George R.

1979-01-01

Mary Bidwell Breed predicted that midwestern universities would probably "pass through a stage of educational development in which the liberal arts are entirely feminized, the men are entirely commercialized." We can appreciate how close she came to pinpointing trends which did not begin to be reversed until sixty years later.…

Mary McAuliffe. Twilight of the Belle Epoque: The Paris of Picasso, Stravinsky, Proust, Renault, Marie Curie, Gertrude Stein, and Their Friends through the Great War. Lanham, MD: Rowman and Littlefield. 2014. vii + 418 pp.

Directory of Open Access Journals (Sweden)

Eric Martone

2015-01-01

Full Text Available Review of Mary McAuliffe. Twilight of the Belle Epoque: The Paris of Picasso, Stravinsky, Proust, Renault, Marie Curie, Gertrude Stein, and Their Friends through the Great War . Lanham, MD: Rowman and Littlefield. 2014. vii + 418 pp.

Paying tribute to florence nightingale and Mary Seacole.

Science.gov (United States)

Grainger, Angela

2012-05-30

Lynn McDonald (letters May 16) says the grounds of St Thomas' Hospital in London are the wrong place for the proposed memorial statue to Mary Seacole, pointing out that the hospital is more associated with Florence Nightingale and her work.

Edith Marie Thompson (1877–1961), sports and empire settlement administrator

OpenAIRE

Williams, Jean

2012-01-01

Thompson, Edith Marie (1877–1961), sports and empire settlement administrator, was born at 44 Russell Road, Kensington, London, on 19 May 1877, the only daughter of William Frederic Thompson (1847/8–1921), barrister and mineral and chemical merchant, and his wife, Marie Charlotte, née Warde (1849/50–1900). She was educated at Norland Place School and was a boarder at Cheltenham Ladies' College in 1892–3, at a period when there was still very little sport played at the school. In January 1895,...

Classroom Instruction: The Influences of Marie Clay

Science.gov (United States)

McNaughton, Stuart

2014-01-01

Marie Clay's body of work has influenced classroom instruction in direct and indirect ways, through large overarching themes in our pedagogical content knowledge as well as specific smart practices. This paper focuses on her the contributions to our thinking about instruction which come from two broad theoretical concepts; emergent literacy…

Läbi legendide William Shakespeare'i poole / Maris Peters

Index Scriptorium Estoniae

Peters, Maris

2010-01-01

Tutvustus: Wells, Stanley. Kas on tõsi, et Shakespeare ...? / tõlkinud Maris Peters. Tallinn : Argo, 2010. Raamat William Shakespeare kohta käivatest legendidest, kuuldustest ja teooriatest ning tema teoste autorsusest

Anne-Marie Sargueil: ilu on kasulik / intervjueerinud Emilie Toomela

Index Scriptorium Estoniae

Sargueil, Anne-Marie

2015-01-01

Prantsuse Disainiinstituudi juht Anne-Marie Sargueil rääkis prantsuse ja skandinaavia disainist, prantslaste disainieelistustest, uutest suundadest disaini valdkonnas, Eesti Tarbekunsti- ja Disainimuuseumis avatud näitusest "20 prantsuse disainiikooni"

Tip 2 Diabetes Mellituslu Hastalarda Mikroalbuminüri, İnsülin Direnci ve Kardiyovasküler Risk

OpenAIRE

ERSOY, Canan; TAŞLI, Babürşah; YILDIZ, Abdülmecit; İMAMOĞLU, Şazi

2006-01-01

Son çalışmalar tip 2 diyabette mikroalbuminüri (MAU) varlığı ile hedef organ hasarları ve kardiyovasküler hastalık riski arasındaki ilişkilere yönelmişlerdir. Bu çalışmada, Tip 2 diabetes mellituslu (DM) hastalarda MAU ile glisemik kontrol, insülin direnci (İR) ve diğer kardiyovasküler risk faktörleri arasındaki ilişki değerlendirilmiştir. İnsülin gereksinimi olmayan, normal renal fonksiyonlu 29 mikroalbuminürik ve 68 normoalbuminürik tip 2 DM'lu hasta çalışmaya dahil edildi. Tüm hast...

Entrevista com Marie Raynal, Redatora chefe da Revista Diversité - França (Tradução. Interview with Marie Raynal, editor of Diversité - France (Translation

Directory of Open Access Journals (Sweden)

Abramowicz, Anete

2009-11-01

Full Text Available A Revista Eletrônica de Educação teve o privilégio de entrevistar Marie Raynal, que apesar de muitas atividades nos concedeu um tempo para nos responder. Marie Raynal é Responsável pelo Departamento Ville-Ecole-Intégration (Cidade-Escola-Integração em Montrouge, França e Redatora Chefe (rédactrice em chef da Revista Diversité que é um dos únicos periódicos da educação na França que acolhe artigos sobre a diversidade social. Em 2003 foi criado o departamento “Ville & Education” sob a coordenação de Marie Raynal. Este departamento tem por missão acompanhar todos os atores da educação (professores, quadros da educação, coletividades, associações, etc. que tem por encargo - durante e fora do tempo escolar - as crianças e os jovens em situação de fragilidade, especialmente aqueles que vivem nos bairros da política da cidade, àqueles que se destacam por uma educação prioritária, os recém chegados na França e as crianças nômades. No conjunto destas questões, este departamento é considerado como expert nacional. Este departamento possui três revistas e uma carta de informação, entre elas está a revista trimestral em Ciências Sociais, a Diversité.The Revista Eletrônica de Educação (Electronic Journal of Education has the privilege to interview Marie Raynal, which although having many activities, dedicated us time to answer it. Marie Raynal is head of the Département de Ville-Ecole-Intégration (Department of City-School-Integration in Montrouge, France and Chief editor of the journal Diversité, which includes articles on social diversity. In 2003, the department "Ville & Education" is created under the authority of Marie Raynal. Its mission is to accompany all education members (teachers, education managers, communities, associations, etc. that are in charge, during and after school time, children and youth in situations of fragility, including those living in neighborhood of the city policy, those

Costume Cinema and Materiality Telling the Story of Marie Antoinette through Dress

OpenAIRE

Therése Andersson

2011-01-01

In ‘Costume Cinema and Materiality: Telling the Story of Marie Antoinette through Dress’ a materiality-based approach for analysing film narratives through costumes is examined. Sofia Coppola’s film Marie Antoinette (2006) serves as the empirical starting point and the theme of dressing and redressing is pursued throughout the film, crystallizing costume as a significant feature for reading the movie. The article argues that costumes, on a symbolic level, work as agents. It thus focuses on th...

Properties of the fullerene C_6_0-containing PN Lin49 in the SMC; Explanations of strong near-IR excess

International Nuclear Information System (INIS)

Otsuka, Masaaki; Kemper, Francisca; Leal-Ferreira, Marcelo L.; Aleman, Isabel; Ochsendorf, Bram; Bernard-Salas, Jeronimo; Cami, Jan; Peeters, Els

2016-01-01

We performed a detailed spectroscopic analysis of the fullerene C_6o-containing planetary nebula (PN) Lin49 in the Small Magellanic Cloud (SMC). Lin49 is a C-rich and metal- deficient PN (Z∼⃒0.0006) and its nebular abundances are in agreement with the AGB model for the initially 1.25M_☉ stars with the metallicity Z = 0.001 of Fishlock et al. (2014, [1]). By stellar absorption fitting with TLUSTY, we derived stellar abundances, effective temperature, and surface gravity. We constructed the photo-ionization model with CLOUDY in order to investigate physical conditions of Lin49. The model with the 0.005-0.1 μm radius graphite and a constant hydrogen density shell could not fit the ∼⃒1-5 μm SED owing to the strong near-IR excess. We propose that the near-IR excess indicates (1) the presence of extremely small carbon molecules or (2) the presence of high-density structure surrounding the central star. (paper)

Crystal structures of MW1337R and lin2004: Representatives of a novel protein family that adopt a four-helical bundle fold

Energy Technology Data Exchange (ETDEWEB)

Kozbial, Piotr; Xu, Qingping; Chiu, Hsiu-Ju; McMullan, Daniel; Krishna, S. Sri; Miller, Mitchell D.; Abdubek, Polat; Acosta, Claire; Astakhova, Tamara; Axelrod, Herbert L.; Carlton, Dennis; Clayton, Thomas; Deller, Marc; Duan, Lian; Elias, Ylva; Elsliger, Marc-André; Feuerhelm, Julie; Grzechnik, Slawomir K.; Hale, Joanna; Han, Gye Won; Jaroszewski, Lukasz; Jin, Kevin K.; Klock, Heath E.; Knuth, Mark W.; Koesema, Eric; Kumar, Abhinav; Marciano, David; Morse, Andrew T.; Murphy, Kevin D.; Nigoghossian, Edward; Okach, Linda; Oommachen, Silvya; Reyes, Ron; Rife, Christopher L.; Spraggon, Glen; Trout, Christina V.; ban den Bedem, Henry; Weekes, Dana; White, Aprilfawn; Wolf, Guenter; Zubieta, Chloe; Hodgson, Keith O.; Wooley, John; Deacon, Ashley M.; Godzik, Adam; Lesley, Scott A.; Wilson, Ian A. (Scripps); (SSRL); (JCSG); (UCSD); (Burnham)

2009-08-28

To extend the structural coverage of proteins with unknown functions, we targeted a novel protein family (Pfam accession number PF08807, DUF1798) for which we proposed and determined the structures of two representative members. The MW1337R gene of Staphylococcus aureus subsp. aureus Rosenbach (Wood 46) encodes a protein with a molecular weight of 13.8 kDa (residues 1-116) and a calculated isoelectric point of 5.15. The lin2004 gene of the nonspore-forming bacterium Listeria innocua Clip11262 encodes a protein with a molecular weight of 14.6 kDa (residues 1-121) and a calculated isoelectric point of 5.45. MW1337R and lin2004, as well as their homologs, which, so far, have been found only in Bacillus, Staphylococcus, Listeria, and related genera (Geobacillus, Exiguobacterium, and Oceanobacillus), have unknown functions and are annotated as hypothetical proteins. The genomic contexts of MW1337R and lin2004 are similar and conserved in related species. In prokaryotic genomes, most often, functionally interacting proteins are coded by genes, which are colocated in conserved operons. Proteins from the same operon as MW1337R and lin2004 either have unknown functions (i.e., belong to DUF1273, Pfam accession number PF06908) or are similar to ypsB from Bacillus subtilis. The function of ypsB is unclear, although it has a strong similarity to the N-terminal region of DivIVA, which was characterized as a bifunctional protein with distinct roles during vegetative growth and sporulation. In addition, members of the DUF1273 family display distant sequence similarity with the DprA/Smf protein, which acts downstream of the DNA uptake machinery, possibly in conjunction with RecA. The RecA activities in Bacillus subtilis are modulated by RecU Holliday-junction resolvase. In all analyzed cases, the gene coding for RecU is in the vicinity of MW1337R, lin2004, or their orthologs, but on a different operon located in the complementary DNA strand. Here, we report the crystal structures

Raamatukogu esisele kerkib kevadel Marie Underi kuju / Andres Eilart

Index Scriptorium Estoniae

Eilart, Andres

2009-01-01

Skulptor Mati Karminil ja arhitekt Tiit Trummalil valmib valgest marmorist mälestusmärk Marie Underile. Kuju püstitatakse 2010. a. kevadel Eesti Rahvusraamatukogu ette. Alale on kavandatud ka veekaskaadid

Charcot-Marie-Tooth disease type 1A

DEFF Research Database (Denmark)

Hertz, Jens Michael; Børglum, A D; Brandt, C A

1994-01-01

Charcot-Marie-Tooth disease type 1A (CMT1A) is an autosomal dominant peripheral neuropathy associated with a DNA duplication on chromosome 17p11.2-p12 in the majority of cases. Most of the sporadic cases are due to a de novo duplication. We have screened for this duplication in 11 Danish patients...

The design and research of anti-color-noise chaos M-ary communication system

Energy Technology Data Exchange (ETDEWEB)

Fu, Yongqing, E-mail: fuyongqing@hrbeu.edu.cn; Li, Xingyuan; Li, Yanan [College of information and Communication Engineering, Harbin Engineering University, Harbin 150001 (China); Zhang, Lin [College of Underwater Acoustic Engineering, Harbin Engineering University, Harbin 150001 (China)

2016-03-15

Previously a novel chaos M-ary digital communication method based on spatiotemporal chaos Hamilton oscillator has been proposed. Without chaos synchronization circumstance, it has performance improvement in bandwidth efficiency, transmission efficiency and anti-white-noise performance compared with traditional communication method. In this paper, the channel noise influence on chaotic modulation signals and the construction problem of anti-color-noise chaotic M-ary communication system are studied. The formula of zone partition demodulator’s boundary in additive white Gaussian noise is derived, besides, the problem about how to determine the boundary of zone partition demodulator in additive color noise is deeply studied; Then an approach on constructing anti-color-noise chaos M-ary communication system is proposed, in which a pre-distortion filter is added after the chaos baseband modulator in the transmitter and whitening filter is added before zone partition demodulator in the receiver. Finally, the chaos M-ary communication system based on Hamilton oscillator is constructed and simulated in different channel noise. The result shows that the proposed method in this paper can improve the anti-color-noise performance of the whole communication system compared with the former system, and it has better anti-fading and resisting disturbance performance than Quadrature Phase Shift Keying system.

The design and research of anti-color-noise chaos M-ary communication system

International Nuclear Information System (INIS)

Fu, Yongqing; Li, Xingyuan; Li, Yanan; Zhang, Lin

2016-01-01

Previously a novel chaos M-ary digital communication method based on spatiotemporal chaos Hamilton oscillator has been proposed. Without chaos synchronization circumstance, it has performance improvement in bandwidth efficiency, transmission efficiency and anti-white-noise performance compared with traditional communication method. In this paper, the channel noise influence on chaotic modulation signals and the construction problem of anti-color-noise chaotic M-ary communication system are studied. The formula of zone partition demodulator’s boundary in additive white Gaussian noise is derived, besides, the problem about how to determine the boundary of zone partition demodulator in additive color noise is deeply studied; Then an approach on constructing anti-color-noise chaos M-ary communication system is proposed, in which a pre-distortion filter is added after the chaos baseband modulator in the transmitter and whitening filter is added before zone partition demodulator in the receiver. Finally, the chaos M-ary communication system based on Hamilton oscillator is constructed and simulated in different channel noise. The result shows that the proposed method in this paper can improve the anti-color-noise performance of the whole communication system compared with the former system, and it has better anti-fading and resisting disturbance performance than Quadrature Phase Shift Keying system.

José Lins do Rego: um guia brasileiro de Israel

Directory of Open Access Journals (Sweden)

Glauber Pereira Quintão

2010-03-01

Full Text Available Este artigo procura analisar, de forma crítica, o livro de José Lins do Rego, Roteiro de Israel, 1955. Busca-­se destacar duas facetas suplementares: a de um olhar poético e a de uma preocupação ético-política lançados pelo escritor sobre a construção do novo Estado de Israel. Observa-­se também uma relação entre os signos da modernidade e das histórias arcaica judaicas. Para isso, usa-­se o conceito de palimpsesto, de Gerard Genette, e de flâneur, de Walter Benjamim.

Mary Tyler Moore Helps Launch NIH MedlinePlus Magazine

Science.gov (United States)

... Issues Mary Tyler Moore Helps Launch NIH MedlinePlus Magazine Past Issues / Winter 2007 Table of Contents For ... Javascript on. Among those attending the NIH MedlinePlus magazine launch on Capitol Hill were (l-r) NIH ...

Mari Koger : seina sisse ehitatud akvaariumiga poissmehekodu / Gitte Hint

Index Scriptorium Estoniae

Hint, Gitte

2003-01-01

80-ruutmeetrine poissmehekorter Viimsi uues elamus. Elutoa ja vannitoa vahelises seinas paikneb kahelt poolt vaadeldav akvaarium. Magamistoa üks seintest on ehitatud vanadest tellistest. Sisearhitekt Mari Koger, tema kommentaarid. Ill.: plaan, 9 värv. vaadet

Rehabilitation programme for the Mary Kathleen uranium mine

International Nuclear Information System (INIS)

Duffield, I.R.; Ward, T.A.

1989-01-01

The Mary Kathleen uranium deposit was located in the North West region of the state of Queensland, Australia. It was discovered in 1954 and mined in two phases for a total of twelve years between 1958 and 1982. In October 1982 operations at the site ceased with the deposit virtually exhausted and all contractual commitments completed. From the outset, a site specific approach was adopted in developing the rehabilitation plan. Other sites'experience was evaluated but was adopted only if appropriate for Mary Kathleen. As a result of this approach a conceptual solution was established for each area within the site. Each solution was then used as the basis for detailed planning for rehabilitation of that area. The rehabilitation program commenced in mid 1982 and was completed in late 1985. Results of monitoring provided a strong basis for confidence that the objectives of the plan have been met, and allowed for the relinquishment of all the remaining mining leases in August 1987

Synthèse et validation d'une loi de commande linéaire robuste de braquage d'une automobile

OpenAIRE

MENHOUR, Lghani; LECHNER, Daniel; CHARARA, Ali

2010-01-01

Ce papier propose la synthèse d'un retour d'état robuste préprogrammé pour le contrôle de direction d'un véhicule. Celui-ci est utilisé pour simuler le comportement du véhicule sous des fortes sollicitations dynamiques. Les contraintes d'inégalités matricielles linéaires (LMI) et un modèle linéaire à paramètres variants sont utilisés pour la synthèse du retour d'état. Ensuite, une méthode d'interpolation des gains est utilisée pour la conception d'un retour d'état robuste préprogrammé. La str...

Mariátegui e a ocidentalização da política Mariátegui and the occidentalization of politics

Directory of Open Access Journals (Sweden)

Ricardo Melgar Bao

2007-05-01

Full Text Available A contribuição de Mariátegui para pensar o socialismo na América Latina é resgatada por meio das críticas à marginalização cultural e política dos povos não-ocidentais, bem como do particular uso que deu ao marxismo, acentuando-lhe as características universais através da apropriação cultural dos diversos contextos. Palavras-chave: América Latina. Oriente. Ocidente. Marxismo. Socialismo. Civilização. Cultura. Identidade. The contribution of Mariátequi for the view of socialism in Latin America is recovered not only through the criticism of the cultural and political marginal position of the non-western people but also through the particular way he used marxism, reinforcing its universal characteristics by the cultural appropriation of different cultural contexts. Keywords: Latin America. East. West. Marxism. Socialism. Civilization. Culture. Identity.

Functional study of risk loci of stem cell-associated gene lin-28B and associations with disease survival outcomes in epithelial ovarian cancer.

Science.gov (United States)

Lu, Lingeng; Katsaros, Dionyssios; Mayne, Susan T; Risch, Harvey A; Benedetto, Chiara; Canuto, Emilie Marion; Yu, Herbert

2012-11-01

Several single-nucleotide polymorphisms (SNPs) of the stem cell-associated gene lin-28B have been identified in association with ovarian cancer and ovarian cancer-related risk factors. However, whether these SNPs are functional or might be potential biomarkers for ovarian cancer prognosis remains unknown. The purposes of this study were to investigate the functional relevance of the identified lin-28B SNPs, as well as the associations of genotype and phenotype with epithelial ovarian cancer (EOC) survival. We analyzed five SNPs and mRNA levels of lin-28B in 211 primary EOC tissues using Taqman(®) SNP genotyping assays and SYBR green-based real-time PCR, respectively. The RNA secondary structures at the region of a genome-wide association-identified intronic rs314276 were analyzed theoretically with mfold and experimentally with circular dichroism spectroscopy. We found that rs314276 was a cis-acting expression quantitative trait locus (eQTL) in both additive and dominant models, while rs7759938 and rs314277 were significant or of borderline significance in dominant models only. The rs314276 variant significantly affects RNA secondary structure. No SNPs alone were associated with patient survival. However, we found that among patients initially responding to chemotherapy, those with higher lin-28B expression had higher mortality risk (hazard ratio =3.27, 95% confidence interval: 1.63-6.56) and relapse risk (hazard ratio = 2.53, 95% confidence interval: 1.41-4.54) than those with lower expression, and these associations remained in multivariate analyses. These results suggest that rs314276 alters RNA secondary structure and thereby influences gene expression, and that lin-28B is a cancer stem cell-associated marker, which may be a pharmaceutical target in the management of EOC.

33 CFR 207.440 - St. Marys Falls Canal and Locks, Mich.; use, administration, and navigation.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false St. Marys Falls Canal and Locks... CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE NAVIGATION REGULATIONS § 207.440 St... include all of the natural waters of the St. Marys River on the U.S. side of the International Boundary...

Marie Curie: In the laboratory and on the battlefield

International Nuclear Information System (INIS)

Badash, Lawrence

2003-01-01

This year is the centennial of the Nobel Prize in Physics shared by Henri Becquerel and the Curies for their pioneering work on radioactivity. But Marie Curie's contribution to the medical use of x rays is not widely known

Exploring the Universe with John Milton and Mary Shelley.

Science.gov (United States)

Poston, David

1989-01-01

Presents an approach to teaching John Milton's "Paradise Lost" in conjunction with Mary Shelley's "Frankenstein." Notes that a study of these works stimulates vigorous discussions on theological and moral issues, human nature, and the cultural past and future. (MM)

Reklaamid nagu kino / Jean Marie Bouriscot ; interv.Valner Valme

Index Scriptorium Estoniae

Bouriscot, Jean Marie

2001-01-01

Sakala keskuses toimus reedel 6. korda reklaamiõgijate öö, kus näidati reklaamiklippe Jean Marie Bouriscotþ kogust. Kogu omanik polnud küll seekord ise kohal, kuid vastas siiski ajakirjaniku küsimustele oma huviala kohta

LEDWIRE: A Versatile Networking Platform for Smart LED Lighting Applications Using LIN-Bus and WSNs

Directory of Open Access Journals (Sweden)

Dimitrios D. Piromalis

2016-05-01

Full Text Available In this paper, the architecture of a versatile networking and control platform for Light-Emitting Diode (LED lighting applications is presented, based on embedded wireless and wired networking technologies. All the possible power and control signals distribution topologies of the lighting fixtures are examined with particular focus on dynamic lighting applications with design metrics as the cost, the required wiring installation expenses and maintenance complexity. The proposed platform is optimized for applications where the grouping of LED-based lighting fictures clusters is essential, as well as their synchronization. With such an approach, the distributed control and synchronization of LED lighting fixtures' clusters is performed through a versatile network that uses the single wire Local Interconnect Network (LIN bus. The proposed networking platform is presented in terms of its physical layer architecture, its data protocol configuration, and its functionality for smart control. As a proof of concept, the design of a LED lighting fixture together with a LIN-to-IEEE802.15.4/ZigBee data gateway is presented.

Activity report 2010 of the Committee of expertise and follow-through of the ANDRA's information and consultation approach (Coesdic); Le comite d'expertise et de suivi de la demarche d'information et de consultation de l'Andra (Coesdic). Rapport d'activites 2010

Energy Technology Data Exchange (ETDEWEB)

NONE

2011-07-01

This report first recalls the missions and operation modalities of the Coesdic which has been created to monitor the ANDRA's mission of public information within the frame of its investigations and researches on deep geological and reversible storage of high and intermediate level nuclear wastes. It describes the activities of the Coesdic concerning the Cigeo project (previously name HA-MAVL project): modalities for the selection of areas of interest, project governance, preparation of the public debate on deep geological storage. It also describes the activities related to the management of low level nuclear wastes. It also discusses social and human issues

Üleujutus arendaja hingel / Maris Kuuda

Index Scriptorium Estoniae

Kuuda, Maris

2007-01-01

Kohalikel omavalitsustel pole piisavalt hoobasid sundida arendajaid üleujutusohuga arvestama. Pärnusse hotelli September rajajad (arhitektid Emil Urbel, Andrus Mark) arvestavad ujutusohuga. Arvamust avaldavad Rene Reisner, Mari Sepp, Ülo Sults, Karri Tiigisoon, Indrek Rannik, Mark Soosaar, Tiiu Pärn, Merle Looring, Rita Sepp, Kaspar Alles. Keskkonnaministeeriumi plaanist muuta veeseadust, mis sunniks ehitajaid ja arendajaid arvestama üleujutusohuga. Lisadena olulise üleujutusohuga alad Eestis ning üleujutuste ohjamist käsitleva Euroopa Liidu direktiivi eelnõust

Need sinihallid veised... : Marie Under ja Villem Ridala / Ruth Mirov

Index Scriptorium Estoniae

Mirov, Ruth, 1928-

2008-01-01

Vaadeldakse kahte ühest ja samast muistendist - merest tõusnud lehmakarjast - inspireeritud ballaadi: Marie Underi "Merilehmi" (ilm. kogus "Õnnevarjutus", 1929) ja Villem Ridala "Sinist karja" (ilm. kogus "Sinine kari", 1930)

Ooperi valem : Mari Vihmandi "Armastuse valem" / Evi Arujärv

Index Scriptorium Estoniae

Arujärv, Evi, 1953-

2009-01-01

Argentiina kirjaniku Esther Vilari romaani "Nina Glucksteini matemaatika" ainetel valminud Mari Vihmandi ooperist "Armastuse valem", libreto Maimu Berg, lavastaja Liis Kolle, tantsu- ja liikumisseaded Ana Mondini. Esietendus 17. oktoobril 2008 Rahvusooperis Estonia

Marie Stopes International Child Spacing Clinics in Malawi

African Journals Online (AJOL)

programme, male involvement has the following basic aspects: Initiation of dialogue on child spacing within the ... that men feel that child spacing is also their concern and service providers feel men are not outsiders. ... pioneering work of Marie Stopes in caring for women in the poor communities of London by extending the ...

Revisiting Mary Daly: Towards a quadripartite theological and philosophical paradigm

Directory of Open Access Journals (Sweden)

Hannelie Wood

2015-06-01

Full Text Available I was a tenderfoot in feminist discourse when I started my research on patriarchy, feminism, and Mary Daly. In my thesis, one aspect I engaged was Daly’s battle with gender issues in Christian theology. From the beginning I was troubled by Mary Daly’s views on God, men, and women in her discourse on Christianity. Daly undoubtedly contributed to the discussion on gender issues in the Christian faith, but her focus on androcentrism and her interpretations of Scripture led her to abandon the Christian faith. Mary Daly has written extensively on patriarchy as it is found in religion – particularly in the Christian faith – and how it filters through society. In her critique of patriarchy she set her course to dismantle the facade of a patriarchal and misogynistic God as the root of patriarchy. Daly did not see any positive qualities of the Christian faith and completely rejected other interpretations of a God whose person embraces both male and female qualities. Against this background I will evaluate Daly’s post-Christian feminist theological and philosophical paradigm. I propose that Daly has a quadripartite theological and philosophical paradigm wherein there are four main players. The ‘Who is who’ in Daly’s quadripartite patriarchal theological and philosophical paradigm are the patriarchal male, the patriarchal female, the patriarchal God and the biophilic woman.

ALS5/SPG11/KIAA1840 mutations cause autosomal recessive axonal Charcot-Marie-Tooth disease.

Science.gov (United States)

Montecchiani, Celeste; Pedace, Lucia; Lo Giudice, Temistocle; Casella, Antonella; Mearini, Marzia; Gaudiello, Fabrizio; Pedroso, José L; Terracciano, Chiara; Caltagirone, Carlo; Massa, Roberto; St George-Hyslop, Peter H; Barsottini, Orlando G P; Kawarai, Toshitaka; Orlacchio, Antonio

2016-01-01

Charcot-Marie-Tooth disease is a group of hereditary peripheral neuropathies that share clinical characteristics of progressive distal muscle weakness and atrophy, foot deformities, distal sensory loss, as well as diminished tendon reflexes. Hundreds of causative DNA changes have been found, but much of the genetic basis of the disease is still unexplained. Mutations in the ALS5/SPG11/KIAA1840 gene are a frequent cause of autosomal recessive hereditary spastic paraplegia with thin corpus callosum and peripheral axonal neuropathy, and account for ∼ 40% of autosomal recessive juvenile amyotrophic lateral sclerosis. The overlap of axonal Charcot-Marie-Tooth disease with both diseases, as well as the common autosomal recessive inheritance pattern of thin corpus callosum and axonal Charcot-Marie-Tooth disease in three related patients, prompted us to analyse the ALS5/SPG11/KIAA1840 gene in affected individuals with autosomal recessive axonal Charcot-Marie-Tooth disease. We investigated 28 unrelated families with autosomal recessive axonal Charcot-Marie-Tooth disease defined by clinical, electrophysiological, as well as pathological evaluation. Besides, we screened for all the known genes related to axonal autosomal recessive Charcot-Marie-Tooth disease (CMT2A2/HMSN2A2/MFN2, CMT2B1/LMNA, CMT2B2/MED25, CMT2B5/NEFL, ARCMT2F/dHMN2B/HSPB1, CMT2K/GDAP1, CMT2P/LRSAM1, CMT2R/TRIM2, CMT2S/IGHMBP2, CMT2T/HSJ1, CMTRID/COX6A1, ARAN-NM/HINT and GAN/GAN), for the genes related to autosomal recessive hereditary spastic paraplegia with thin corpus callosum and axonal peripheral neuropathy (SPG7/PGN, SPG15/ZFYVE26, SPG21/ACP33, SPG35/FA2H, SPG46/GBA2, SPG55/C12orf65 and SPG56/CYP2U1), as well as for the causative gene of peripheral neuropathy with or without agenesis of the corpus callosum (SLC12A6). Mitochondrial disorders related to Charcot-Marie-Tooth disease type 2 were also excluded by sequencing POLG and TYMP genes. An additional locus for autosomal recessive Charcot-Marie

Eesti animafilm külvab uusi seemneid / Mari-Liis Rebane

Index Scriptorium Estoniae

Rebane, Mari-Liis

2009-01-01

PÖFFi alafestivalil Animated Dreams linastunud neljast uuest filmist: Olga ja Priit Pärna "Tuukrid vihmas", Kaspar Jancise "Krokodill", Martinus Daane Klemeti "Õhus" ja Girlin Bassovskaja (Jelena Girlin, Mari-Liis Bassovskaja) "Oranus"

An Adaptation of the Kernighan-Lin Heuristic to the Simple Graph Partitioning Problem

DEFF Research Database (Denmark)

Sørensen, Michael Malmros

1999-01-01

to this problem of the Kernighan-Lin exchange heuristic, which was originally developed for the closely related 2-partition problem. The evaluation is carried out on problem instances on graphs with up to 50 nodes for which the optimal partition values are known or upper bounds are available. The computational...... results show that among all instances with known optimal values the best partition values found by a randomized version of this heuristic lie well within 1% off the optimum....

Dysfunction in the hip joints in children with Charcot-Marie-Tooth syndrome (literature review

Directory of Open Access Journals (Sweden)

Ivan Yurievich Pozdnikin

2015-09-01

Full Text Available A review of the literature on the treatment of children with dysfunction in the hip joints in motor-sensory neuropathy Charcot-Marie-Tooth is presented. Peculiarities of disease diagnosis and the approach used in the treatment of patients are described. The Charcot-Marie-Tooth syndrome is a hereditary neuromuscular disease characterized by progressive atrophy of the distal muscle group of the lower limbs. According to international authors, the incidence of hip joint dysfunction in this condition is at least 10%, ranking second only to foot deformities. In the Russian literature, the problem has not been adequately interpreted. Early diagnosis of dysfunction in the hip joints during Charcot-Marie-Tooth syndrome is complicated by the child's age and is characterized by progression. Conflicting clinical signs and trivial symptoms of the disease also confuse diagnosis, until it becomes clearer in adolescence or the second or third decade of life. Surgical reconstructive operations on the hip joint often occur too late, and they are accompanied by a greater frequency of neurological complications. Practitioner awareness coupled with an early diagnosis of hip subluxation and decentration and complex orthopedic and neurological examinations of children with the disease of Charcot-Marie-Tooth should result in more favorable outcomes.

Deployment of Autonomous GPS Stations in Marie Byrd Land, Antartica

Science.gov (United States)

Donnellan, A.; Luyendyk, B.; Smith, M.; Dace, G.

1999-01-01

During the 1998-1999 Antarctic field season, we installed three autonomous GPS stations in Marie Byrd Land, West Antarctica to measure glacio-isostatic rebound and rates of spreading across the West Antartic Rift System.

Preparing as an organization, to submit or to review a construction license application for a DGR of ILW and HLW in France. French National Case - Andra - Preparing to Submit Cigeo's Creation License Application

International Nuclear Information System (INIS)

Boissier, Fabrice; Labalette, T.; Leverd, Pascal C.; Voinis, Sylvie

2014-01-01

The reversible repository in a deep geological formation is the French reference solution for the long-term management of high-level and intermediate-level long-lived radioactive waste. Since the first French Act on nuclear waste management research (1991), Andra has carried out twenty years of conceptual and basic studies on the subject, leading in particular to the feasibility demonstration in 2005 and to the choice of the detailed reconnaissance zone (ZIRA) in 2010. Taking advantage from this work, Andra has now reached a new phase where the project is engaging in the design of the industrial installation named Cigeo. At this stage, the further development of the project implies that Andra undertakes a multiplicity of actions in order to successfully reach various external and internal key milestones. Of paramount importance is the careful articulation between the regulatory authorization and decision processes and the outcome of the industrial installation design phases. In 2006 was built a regulatory framework that plans a succession of step by step decisions stages: 2013: Public debate on reversibility, memory keeping, environmental and health survey modalities, dialogue with the local stakeholders to harmoniously define and plan the external infrastructures that have to be developed to support the construction and the operation of Cigeo (roads, railway tracks and terminal, power and water supplies, etc.). 2015: Creation license application and start of the regulatory review process (notably various plans of the installation, the description of the solution envisaged for the closure of the facility, the preliminary safety case (operational safety, long-term safety, protection against malevolent actions, management of incidental situations, preliminary acceptance criteria), environmental impact studies (health, salubrity, transports, human activities, nature, patrimonial aspects). 2016-2017: new parliamentary Act on the reversibility conditions of the

Mitochondrial DNA analysis on remains of a putative son of Louis XVI, King of France and Marie-Antoinette.

Science.gov (United States)

Jehaes, E; Decorte, R; Peneau, A; Petrie, J H; Boiry, P A; Gilissen, A; Moisan, J P; Van den Berghe, H; Pascal, O; Cassiman, J J

1998-01-01

Carl Wilhelm Naundorff was buried in 1845 in Delft as Louis Charles, Duc de Normandie, 'Louis XVII'. However, the son of Louis XVI and Marie-Antoinette-Louis XVII--officially died in the Temple of Paris in 1795. In order to resolve the identity of Naundorff, mitochondrial DNA (mtDNA) D-loop sequences of his remains were compared with the sequences obtained from the hairs of two sisters of Marie-Antoinette, Marie-Antoinette herself, and with the sequences obtained from DNA samples of two living maternal relatives. The mtDNA sequence of a bone sample from Naundorff showed two nucleotide differences from the sequences of the three sisters and four differences from the sequences of living maternal relatives. Based on this evidence it becomes very unlikely that Naundroff is the son of Marie-Antoinette.

2017-2018 Travel Expense Reports for Mary Anne Chambers ...

International Development Research Centre (IDRC) Digital Library (Canada)

Chantal Taylor

Ottawa. Airfare: $368.41. Other. Transportation: $69.95. Accommodation: $542.79. Meals and. Incidentals: $164.42. Other: $0.00. Total: $1,145.57. Comments: From residence in Thornhill, Ontario. 2017-2018 Travel Expense Reports for Mary. Anne Chambers, Governor, Chairperson of the. Human Resources Committee.

2017-2018 Travel Expense Reports for Mary Anne Chambers ...

International Development Research Centre (IDRC) Digital Library (Canada)

Chantal Taylor

Ottawa. Airfare: $563.72. Other. Transportation: $74.26. Accommodation: $0.00. Meals and. Incidentals: $46.17. Other: $30.00. Total: $714.15. Comments: From residence in Thornhill, Ontario. 2017-2018 Travel Expense Reports for Mary. Anne Chambers, Governor, Chairperson of the. Human Resources Committee.

Two wives in science service: Marie Curie and Irene Joliot-Curie

International Nuclear Information System (INIS)

Bordry, M.

1996-01-01

This paper relates the life and the scientific works of Marie Curie and of her daughter Irene Joliot-Curie in their historical context. Several details are given about their laboratory works, their relations with students, the creation of the Radium Institute and the role they played during the two world wars. The progress of their works towards their main scientific discoveries (polonium, radium, artificial radioactivity, transuranium compounds etc..) is illustrated with some extracts of their personal correspondence with relatives. The paper evokes also the Nobel prices received by Pierre and Marie Curie and by Irene and Frederic Joliot and the creation of the CEA by Frederic Joliot in 1946. (J.S.). 6 photos

Modelling an in-situ ventilation test in the Andra Underground Research Facilities

Directory of Open Access Journals (Sweden)

Collin Frédéric

2016-01-01

Full Text Available Wastes resulting from the nuclear electricity production have to be isolated from the biosphere for a very long period of time. For this purpose, deep underground repository in weak permeable geological layers is considered as a reliable solution for the nuclear waste storage. It is however well established that during excavation, the underground drilling process engenders cracks and eventually fractures [1] that deteriorate the hydro-mechanical properties of the surrounding host material in the so-called Excavation Damaged Zone (EDZ. The EDZ behaviour is a major issue because it may constitute a preferential flow path for radionuclide migration. Consequently, the characterisation of the material transport properties and of the transfer kinetics that occur around galleries still need to be investigated. The EDZ properties may be also affected by host rock-gallery air interactions. Ventilation induced drying may also provoke additional cracking, which potentially alters the transport properties of the damaged zone. Large-scale air ventilation experiments are performed in Underground Research Laboratories (URL that have been constructed to check the feasibility of the repository. A numerical modelling of the SDZ air ventilation test (Andra URL performed in a low permeability rock is proposed in order to both predict the development of the EDZ during excavation and study the air interaction with the host formation during maintenance phases.

Anneli Remme soovitab : Kuninganna Mary elu ja surm / Anneli Remme

Index Scriptorium Estoniae

Remme, Anneli, 1968-

2002-01-01

Kontserdisarja "Hingemuusika" teist kontserti raamivad Henry Purcelli teosed, millest esimene on loodud kuninganna Mary sünnipäevaks, viimane matusetseremooniaks. Barokkansambli Corelli Consort esituses 26., 27., ja 28. apr. Viljandi, Tartu ja Tallinna kirikutes

Mary's Story: A Curriculum for Teaching Medical Terminology.

Science.gov (United States)

Pennsylvania State Univ., University Park. Inst. for the Study of Adult Literacy.

This packet of materials for a class on medical terminology consists of a collection of stories with highlighted vocabulary, teacher's guide, and student's guide. The materials teach medical terms in a series of stories about a woman named Mary Consola. Each story begins with a list of word parts that will be learned; after the story, new word…

2016-2017 Travel Expense Reports for Mary Anne Chambers ...

International Development Research Centre (IDRC) Digital Library (Canada)

Beata Bialic

Date(s):. 2016-07-06. Destination(s):. Ottawa. Airfare: $482.11. Other. Transportation: $64.30. Accommodation: $0.00. Meals and. Incidentals: $25.28. Other: $0.00. Total: $571.69. Comments: 2016-2017 Travel Expense Reports for Mary. Anne Chambers, Governor, Chairperson of the. Human Resources Committee.

1970. aastatel alustas arhitektidest sõprade ja kolleegide rühm... / Mari Laanemets

Index Scriptorium Estoniae

Laanemets, Mari, 1975-

2008-01-01

27.VI avatakse Eesti Arhitektuurimuuseumis Rotermanni soolalaos 1970. ja 1980. alguse eksperimentaalset arhitektuuripraktikat käsitlev näitus "Keskkond, objektid, kontseptsioonid. Tallinna kooli arhitektid 1972-1985". Näha saab Ülevi Eljandi, Ignar Fjuki, Veljo Kaasiku, Tiit Kaljundi, Vilen Künnapu, Leonhard Lapini, Avo-Himm Looveere, Kristin-Mari Looveere, Marika Lõokese, Jüri Okase, Jaan Olliku, Ain Padriku, Toomas Reinu, Andres Ringo, Sirje Runge, Harry Sheini, Tõnis Vindi ja Matti Õunapuu töid. Näituse kuraatorid Andres Kurg ja Mari Laanemets. Samas: "Uue arhitektuuri näituse programm" (1972)

Kunsti kuumtöötlus Läti aladel / Mari Sobolev

Index Scriptorium Estoniae

Sobolev, Mari, 1968-

2004-01-01

Pedvale vabaõhumuuseumis toimunud rahvusvahelisest workshop'ist teemal "Kompost", mille tulemusi presenteeriti 6. VIII 2004. Ignas Kazakeviciuse, Jurate Rakeviciute, Diana Dimzha-Dime, Ule Björn Gundermanni, Remo Randveri, Maris Grosbahsi, Andrus Joonase töödest

Tagasivaade 90-ndate eesti kirjandusele / Märt Väljataga

Index Scriptorium Estoniae

Väljataga, Märt, 1965-

1999-01-01

Vastukajad: Veidemann, Rein. Edasivaade 90-ndate eesti kirjandusele: teksti, metateksti ja konteksti probleem // Looming (1999) nr. 12, lk. 1847-1852 ; Merilai, Arne. Elule lähemale - sic! // Sirp (2000) 14. jaan.., lk. 14

Peal on propaganda, all on tugev off / Valle-Sten Maiste

Index Scriptorium Estoniae

Maiste, Valle-Sten, 1972-

2008-01-01

Lõppeva teatriaasta repertuaarivalikust. Teatriaasta õnnestumiste ja ebaõnnestumiste kohta vastavad küsimustele ka Pille-Riin Purje, Jaak Allik, Rein Veidemann, Rait Avestik, Jim Ashilevi, Eva Kübar, Madli Pesti ja Madis Kolk

The medical applications of the discoveries of Marie Sklodowska-Curie

International Nuclear Information System (INIS)

Krawczyk, M.

2011-01-01

In this work, the author indicates what have been the applications of the discoveries of Marie Curie in the field of medicine and how these discoveries have contributed in particular to the development of oncologic radiotherapy. (O.M.)

Rundum artist-run space and its elusive form / Hanna Laura Kaljo, Mari-Leen Kiipli, Kulla Laas ... [jt.

Index Scriptorium Estoniae

2015-01-01

Rundum on 2013. a septembris Tallinnas loodud liikuv loominguline platvorm, mille eesmärgiks on suhestuda erinevate kohtadega, reageerida tühikutele Eesti loomemaastikus ning uurida sealjuures ka omaalgatuslike praktikate võimalikkust kohalikus kontekstis. Vestlusringis Rundumi algatajad Mari-Leen Kiipli, Kulla Laas, Aap Tepper, Mari Volens, Kristina Õllek

Lin28a Is Dormant, Functional, and Dispensable During Mouse Oocyte-to-Embryo Transition

Czech Academy of Sciences Publication Activity Database

Flemr, Matyáš; Moravec, Martin; Libová, Veronika; Sedláček, Radislav; Svoboda, Petr

2014-01-01

Roč. 90, č. 6 (2014), s. 1-9 ISSN 0006-3363 R&D Projects: GA MŠk LH13084; GA MŠk(CZ) LM2011032; GA ČR(CZ) GBP305/12/G034 Institutional support: RVO:68378050 Keywords : early development * genome activation * guinea pigs * Let-7 * LIN28 * mice * microRNA * oocyte * rats * RNAi * rodents * transgenic/ knockout model * voles * zygote Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 3.318, year: 2014

2005 dossier. ANDRA's researches on the geological disposal of high-level and long-lived radioactive wastes. Results and perspectives

International Nuclear Information System (INIS)

2005-06-01

This document makes a status of the researches carried out by the French national agency of radioactive wastes (ANDRA) about the geologic disposal of high-level and long-lived radioactive wastes in deep geologic formations (argilites and granites). Content: 1 - Research on deep disposal of radioactive waste: general interest task: Legislative framework, ANDRA scientific objectives, Inspections and assessments; 2 - Designing a safe and reversible disposal system: Repository safety, Reversibility: an essential requirement; 3 - Clay Research on a repository in a clay formation, A long research programme, Dossier 2005 Argile; 4 - Meuse/Haute-Marne site clay: Expected properties of the rock formation, Choice of argillite, Meuse/Haute-Marne site, Conclusions from 10 years of research at the Meuse/Haute-Marne site; 5 - Repository installations: Safe and reversible architecture, Disposal of B waste, Disposal of C waste, Possible disposal of spent fuel (CU); 6 - The disposal facility in operation: From waste packages reception to their disposal in cells, Stages of the progressive closure of engineered structures; 7 - Reversible management: Freedom of choice for future generations, Various closure stages; 8 - Long-term evolution of the repository: Apprehending the repository complexity Main evolutions expected, Slow and limited release of radioactive substances; 9 - Repository safety and impact on man: Several evolution scenarios, Normal evolution, Altered evolution; 10 - Granite Research on a repository in a granite formation: A global approach, Scientific co-operations, Dossier 2005 Granite; 11 - Characteristics of French granite formations: What properties are required for a repository?, Different types of granite formations; 12 - Repository installations: Repository design adapted to granite fractures, Clay seals to prevent water flows, Waste disposal packages ensuring long-term leak-tightness, Physical and chemical environment favourable for waste packages, Architecture

2016-2017 Travel Expense Reports for Mary Anne Chambers ...

International Development Research Centre (IDRC) Digital Library (Canada)

chantal taylor

Purpose: Board meetings. Date(s):. 2017-03-19 to 2017-03-22. Destination(s):. Ottawa. Airfare: $121.05. Other. Transportation: $51.92. Accommodation: $926.48. Meals and. Incidentals: $190.40. Other: $0.00. Total: $1,289.85. Comments: 2016-2017 Travel Expense Reports for Mary. Anne Chambers, Governor ...

Umbilical metastasis (Sister Mary Joseph's nodule diagnosed by fine-needle aspiration

Directory of Open Access Journals (Sweden)

Tatomirović Željka

2004-01-01

Full Text Available Sister Mary Joseph’s nodule is the eponym for metastatic involvement of the umbilicus. This less common entity is the sign of disseminated malignant disease, mainly of digestive and gynecologic origin, and is associated with a poor prognosis. A case of Sister Mary Joseph’s nodule in a 76-year-old woman in whom the umbilical metastasis was the first sign of malignant disease in presented. The diagnosis of metastatic adenocarcinoma was established by fine needle aspiration cytology of the umbilical nodule. Radiological and ultrasonographic investigation disclosed carcinoma of the gallbladder with pancreas, stomach, and colon invasion as well as peritoneal dissemination. The diagnosis was confirmed by exploratory laparatomy and histological examination of the excised umbilical nodule.

Mapping Femininity as Self-reflection Strategy in Lady Mary Wortley Montagu’s Travel Letters

OpenAIRE

Amelia Precup

2017-01-01

The present paper participates in the discussion about the differences between masculine and feminine modes of travel in terms of interests, perception, and representation, by exploring the Letters of the Right Honourable Lady M--y W--y M--e Written during Her Travels in Europe, Asia and Africa, by Lady Mary Wortley Montagu. As a traveller, Lady Mary engaged in the contemplation of cultural landscapes: she attempted to understand the social logic of the communities she met and to assess the c...

In honour of Marie Sklodowska-Curie

International Nuclear Information System (INIS)

Karlik, Berta

1967-01-01

This year marks the hundredth anniversary of the birth in Poland of Marie Sklodowska-Curie, originator of the word 'radioactivity', whose early research in the subject has had far-reaching consequences for the nuclear sciences. The Government of Poland's arrangements for marking the occasion include an international symposium, restoration of her house in Warsaw, publications and films, and the Agency is happy to collaborate. This article, from a distinguished Austrian scientist, indicates how her work was carried out in an atmosphere of co-operation between scientists of many nations

Artificial intelligence for Mariáš

OpenAIRE

Kaštánková, Petra

2016-01-01

This thesis focuses on the implementation of a card game, Mariáš, and an artificial intelligence for this game. The game is designed for three players and it can be played with either other human players, or with a computer adversary. The game is designed as a client-server application, whereby the player connects to the game using a web page. The basis of the artificial intelligence is the Minimax algorithm. To speed it up we use the Alpha-Beta pruning, hash tables for storing equivalent sta...

Mart ja Mari-Ann Susi taotlevad omanikena Concordia pankrotti / Andri Maimets

Index Scriptorium Estoniae

Maimets, Andri, 1979-

2003-01-01

Concordia Ülikooli rektor Mart Susi esitas kohtule avalduse, milles taotleb ülikooli pidanud Concordia Varahalduse OÜ pankroti väljakuulutamist. Vt. samas: Mari-Ann Susi õigustas ülikooli raha kasutamist

Optical and electrical properties of zinc oxide thin films with low resistivity via Li-N dual-acceptor doping

Energy Technology Data Exchange (ETDEWEB)

Zhang Daoli, E-mail: zhang_daoli@mail.hust.edu.cn [Department of Electronic Science and Technology, Huazhong University of Science and Technology, No. 1037 Luoyu Road, Hongshan District, Wuhan City, Hubei Province 430074 (China); Wuhan National Laboratory for Optoelectronics, 1037 Luoyu Road, Hongshan District, Wuhan City, Hubei Province 430074 (China); Zhang Jianbing [Department of Electronic Science and Technology, Huazhong University of Science and Technology, No. 1037 Luoyu Road, Hongshan District, Wuhan City, Hubei Province 430074 (China); Wuhan National Laboratory for Optoelectronics, 1037 Luoyu Road, Hongshan District, Wuhan City, Hubei Province 430074 (China); Guo Zhe [Department of Electronic Science and Technology, Huazhong University of Science and Technology, No. 1037 Luoyu Road, Hongshan District, Wuhan City, Hubei Province 430074 (China); Miao Xiangshui [Department of Electronic Science and Technology, Huazhong University of Science and Technology, No. 1037 Luoyu Road, Hongshan District, Wuhan City, Hubei Province 430074 (China); Wuhan National Laboratory for Optoelectronics, 1037 Luoyu Road, Hongshan District, Wuhan City, Hubei Province 430074 (China)

2011-05-19

Highlights: > Zinc oxide films have been deposited on glass substrates by Li-N dual-acceptor doping method via a modified SILAR method. > The resistivity of ZnO film was found to be 1.04 {Omega} cm with a Hall mobility of 0.749 cm{sup 2} V{sup -1} s{sup -1}, carrier concentration of 8.02 x 1018 cm{sup -3}, and transmittance of about 80% in visible range showing good crystallinity with prior c-axis orientation. > A shallow acceptor level of 91 meV is identified from free-to-neutral-acceptor transitions. > Another deep level of 255 meV was ascribed to Li{sub Zn}-Li{sub i} complex. - Abstract: Zinc oxide thin films with low resistivity have been deposited on glass substrates by Li-N dual-acceptor doping method via a modified successive ionic layer adsorption and reaction process. The thin films were systematically characterized via scanning electron microscopy (SEM), atomic force microscopy (AFM), X-ray diffraction, ultraviolet-visible spectrophotometry and fluorescence spectrophotometry. The resistivity of zinc oxide film was found to be 1.04 {Omega} cm with a Hall mobility of 0.749 cm{sup 2} V{sup -1} s{sup -1} and carrier concentration of 8.02 x 10{sup 18} cm{sup -3}. The Li-N dual-acceptor doped zinc oxide films showed good crystallinity with prior c-axis orientation, and high transmittance of about 80% in visible range. Moreover, the effects of Li doping level and other parameters on crystallinity, electrical and ultraviolet emission of zinc oxide films were investigated.

2016-2017 Travel Expense Reports for Mary Anne Chambers ...

International Development Research Centre (IDRC) Digital Library (Canada)

Beata Bialic

Purpose: Board meetings. Date(s):. 2016-11-20 to 2016-11-23. Destination(s):. Ottawa. Airfare: $445.14. Other. Transportation: $29.05. Accommodation: $786.80. Meals and. Incidentals: $76.79. Other: $0.00. Total: $1,337.78. Comments: 2016-2017 Travel Expense Reports for Mary. Anne Chambers, Governor, Chairperson ...

2016-2017 Travel Expense Reports for Mary Anne Chambers ...

International Development Research Centre (IDRC) Digital Library (Canada)

Beata Bialic

Date(s):. 2016-08-14 to 2016-08-23. Destination(s):. Peru/Colombia. Airfare: $3,484.87. Other. Transportation: $0.00. Accommodation: $1,942.21. Meals and. Incidentals: $395.27. Other: $75.50. Total: $5,897.85. Comments: 2016-2017 Travel Expense Reports for Mary. Anne Chambers, Governor, Chairperson of the.

Ruum peaks olema taustaks inimeste mõtetele ja kulgemistele / Mari Koger

Index Scriptorium Estoniae

Koger, Mari

2008-01-01

Autor oma seisukohtadest ja taotlustest sisekujunduses - isikupärast, viimistletusest, avatud voolavast ruumist, stiilide kontrastist ja vanade asjade väärtustamisest. Mari Koger peab koos Taavi Aunrega sisearhitektuuribürood Boom

Saukas ja Karusoo tõid Marie Underi elu teatrilavale / Andres Laasik

Index Scriptorium Estoniae

Laasik, Andres, 1960-2016

2006-01-01

20. nov. Kumu auditooriumis esietendunud Ühenduse R.A.A.A.M teatriprojekt "Under" poetess Marie Underist. Lavastajad Merle Karusoo ja Raimo Pass, kunstnik Jaagup Roomet, helilooja Urmas Lattikas, peaosas Katrin Saukas

Type A aortic dissection associated with Dietzia maris.

Science.gov (United States)

Reyes, Guillermo; Navarro, José-Luis; Gamallo, Carlos; delas Cuevas, María-Carmen

2006-10-01

Aortitis is a rare cause of aortic dissection. We report the unusual presentation of a 77-year-old male patient who underwent emergency surgery for an aortic dissection type A. A purulent pericardial fluid and inflammatory aorta were found after chest opening. Several samples were sent for analysis. The ascending aorta presented a mild dilatation with a large haematoma infiltrating the aortic root. The distal part of the ascending aorta seemed unaffected. The aortic rupture was found one centimetre above the non-coronary cusp. Aortic wall tissues were extremely fragile and with an inflammatory aspect. The patient died in the theatre room. In the histological study one out of three fragments of ascending aorta displayed longitudinal splitting of the outer media, with blood extravasation in the adventitial layer. In this level, the presence of a detritus material that reminded of bacterial colonies was noteworthy, together with abundant fibrinous exudates. In the laboratory a new specimen, Dietzia maris, was found in the pericardial liquid and in the aortic wall. We believe that this is the first reported finding of Dietzia maris in a patient with aortic disease.

The light and brilliancy of Marie Curie

International Nuclear Information System (INIS)

Craig, P.

1984-01-01

The paper describes the life and work of Marie Curie, from her childhood to her death (at nearly 67 years), and including her marriage to Pierre Curie. The scientific work, by the Curies, leading to the discovery of polonium and radium is described, as well as the making of radium chloride. The importance of the Curies' work to theoretical science is briefly discussed, and the effects of radioactivity on the Curies is touched upon. (U.K.)

Muuga / Mary von Grünewaldt ; tõlk. Mati Sirkel

Index Scriptorium Estoniae

Grünewaldt, Mary von

2004-01-01

Leo Zoegelt ostetud Muuga mõisahoone korrastamisest ja uue hoone ehitamisest C. T. von Neffi kunstikogu paigutamise tarbeks. Tütre mälestused. Tõlgitud raamatust: Skizzen und Bilder aus dem Leben Carl Timoleon von Neff / Mary von Grünewaldt. Darmstadt, 1887

Envisioning science : Marie Curie's journey from Poland to Paris

International Nuclear Information System (INIS)

Odlin, S.; Fleming, J.S.

2011-01-01

Marya Sklodovska (nicknamed Manya), born November 1867, was the fifth and youngest child in the Sklodovski family. Marie Curie epitomised the ability to be beautifully creative. Her pioneering spirit gave her the drive to become one of the first women to gain an education, and qualifications, in the sciences. 5 refs., 1 fig.

The “Mari” Hypothesis in the Study of the Toponymy of the Oka and Unzha Rivers and the Western Borders of the Old Mari Toponymic Area

Directory of Open Access Journals (Sweden)

Oleg V. Smirnov

2015-12-01

Full Text Available Referring to toponymic data, the article aims to verify the hypothesis of the western origin of the Mari people who, presumably, migrated to their present-day settlement area from the territory of Kostroma Region and the Oka River basin. The author critically examines the possibility of Mari origin of some place names in the territory in question, namely, of hydronyms ending in -ingir'. To verify the “Mari” hypothesis, the author uses the method of ethnic modelling which consists in the isolation of typical toponymic stems in present-day Mari toponymy and searching for their traces in the substrate toponymy of the studied area. The analysis leads to conclude that it is unlikely that the toponymy of the western part of Kostroma Region and the Oka River basin could be of Mari origin. The area of distribution of typical Mari place names does not display any evidence of Mari substrate or superstrate to the west of the Kerzhanets River basin. On the Western bank of the Volga, some traces of substratal Mari toponymy can be found along the banks of the Sura River as far as the city of Alatyr, however, no Mari “residue” can be found west of the Sura. The absence of Mari substrate in the toponymy of the Oka and Unzha Rivers area makes it possible to refute the hypothesis of the western origin of the Mari and their migration from the area of Gorodets and Dyakovo archaeological cultures. At the same time, the study of phonetic correspondences reflected in place names reveals evidence of close kinship of the substratal dialects of Western Kostroma Region, the low Oka and Klyazma Rivers area with the Mari (Proto-Mari language.

From security to attachment : Mary Ainsworth's contribution to attachment theory

NARCIS (Netherlands)

Rosmalen, Lenette (Lenny) van

2015-01-01

Even though John Bowlby (1907-1990) is generally regarded as the founder of attachment theory, Mary Ainsworth’s (1913-1999) contribution is considerable and goes beyond the design of the Strange Situation Procedure and the introduction of maternal sensitivity as decisive for a secure attachment

Mary E. Hall: Dawn of the Professional School Librarian

Science.gov (United States)

Alto, Teresa

2012-01-01

A century ago, a woman named Mary E. Hall convinced school leaders of the need for the professional school librarian--a librarian who cultivated a love of reading, academic achievement, and independent learning skills. After graduating from New York City's Pratt Institute Library School in 1895, Hall developed her vision for the high school…

Clio goes roller-skating: Images of Memory in some poems by Mary Kennan Herbert Clio goes roller-skating: Images de la mémoire dans quelques poèmes de Mary Kennan Herbert

Directory of Open Access Journals (Sweden)

Jennifer Kilgore

2009-11-01

Full Text Available A few words about Mary Kennan HerbertMary Kennan Herbert is a writer with midwestern roots. She was born in 1938 in St. Louis, Missouri, and spent most of her childhood there. During her adolescent years she lived in Tennessee. She obtained a University degree in art from Peabody College in Nashville. In New York, she pursued a career as editor in a publishing house until the 1980s, when a merger ended her job security. After several attempts at working for different publishers, she started s...

Autosomal recessive Charcot-Marie-Tooth neuropathy.

Science.gov (United States)

Espinós, Carmen; Calpena, Eduardo; Martínez-Rubio, Dolores; Lupo, Vincenzo

2012-01-01

Charcot-Marie-Tooth (CMT) disease, a hereditary motor and sensory neuropathy that comprises a complex group of more than 50 diseases, is the most common inherited neuropathy. CMT is generally divided into demyelinating forms, axonal forms and intermediate forms. CMT is also characterized by a wide genetic heterogeneity with 29 genes and more than 30 loci involved. The most common pattern of inheritance is autosomal dominant (AD), although autosomal recessive (AR) forms are more frequent in Mediterranean countries. In this chapter we give an overview of the associated genes, mechanisms and epidemiology of AR-CMT forms and their associated phenotypes.

Marie Curie's contribution to Medical Physics.

Science.gov (United States)

Jean-Claude, Rosenwald; Nüsslin, Fridtjof

2013-09-01

On occasion of its 50th anniversary, the International Organization for Medical Physics (IOMP) from now on is going to celebrate annually an International Day of Medical Physics for which the 7th November, the birthday of Marie Sklodowska Curie, a most exceptional character in science at all and a pioneer of medical physics, has been chosen. This article briefly outlines her outstanding personality, sketches her fundamental discovery of radioactivity and emphasizes the impact of her various achievements on the development of medical physics at large. © 2013 Published by Elsevier Ltd on behalf of Associazione Italiana di Fisica Medica.

Lithology, hydro-dynamism and thermicity in the multi-layer sedimentary system intersected by the Andra deep borehole of Montiers-sur-Saulx (Meuse, France)

International Nuclear Information System (INIS)

Landrein, Philippe; Vigneron, Georges; Delay, Jacques; Lebon, Patrick; Pagel, Maurice

2013-01-01

Andra (French national radioactive waste management agency) has conducted a research program to determine the feasibility of a disposal facility for long-lived high level and medium level (LL-HLML) nuclear wastes in a deep geological environment. In 2005, following 15 years of research, Andra established the feasibility of this type of disposal in the Callovo-Oxfordian clay formations located in the eastern region of the Paris basin. Between 2006 and 2008, a geological survey campaign was carried out over 250 km 2 at the boundary of the Meuse and Haute-Marne departments. Six drilling platforms were involved on the studied zone and a 2D seismic campaign was carried out using a 2 x 2 km to 3 x 3 km grid as regular as possible. One of the drilling platforms was located in the central area of the studied zone, at a distance of the faults located at the boundary of the studied sector. Three boreholes called EST431, EST432 and EST433 were drilled from this platform. Their main objectives were to contribute to the sitting of the disposal facility, and enhance the knowledge on the formations overlying and underlying the host layer (Dogger, carbonated Oxfordian and Kimmeridgian), as well as on the deep Lias and Trias formations. More specifically, it is meant (i) to acquire a better understanding of the global functioning of the hydrogeological System and the vertical exchanges between the formations and (ii) to assess the potential geothermal resources on the zone in order to verify the absence of exceptional exploitable resources in the vicinity of the site earmarked for the disposal facility. Beyond these objectives, Andra associated the French scientific community to the exploitation of the results yielded by this borehole. Thus, as early as the design stage, Andra entered into a partnership with university laboratories through a program called 'Current and Past transfers in an Aquiferous - Aquitard Sedimentary System'. The partner laboratories were able to carry out

Baltika kvartal = Baltika Quarter / Maris Kerge, Kadri Kerge

Index Scriptorium Estoniae

Kerge, Maris

2010-01-01

Rekonstrueeritud Baltika tööstushoonest: Moetänavast ja AS Baltika büroodest. Projekteerija, sisearhitektuur büroode osas: Studio 3 (4 arhitekti), büroo Kolm Pluss Üks (9 arhitekti). Sisearhitektuur Moetänava osas: Pekka Porkanen, Maris Kerge, Ott Kangur, Maire Milder, Lembit-Kaur Stöör, Ülo-Tarmo Stöör, Lauri Eltermaa, Pärtel Eelma. Projekt: 2007-2009, valmis: 2009

Voice and Body: Emotional Proximity and Physical Distance in Marie de France’s ‘Laustic’

OpenAIRE

Zisa, Jessica

2015-01-01

Through the lens of feminist theoretical questions and gender studies, this paper explores the relationship between voice and body and the emotional and physical distance that occurs between genders in Marie de France’s Laustic. As a medieval woman writer, Marie provides a textual space to examine the emotional closeness and psychological distance that occurs within the patriarchal structure that delineates gender relations within the convention of marriage. This lai or poetic narrative artic...

MaRIE; a proposed materials facility at Los Alamos National Laboratory

Energy Technology Data Exchange (ETDEWEB)

Bourke, M.A.M. [Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States)

2009-06-15

This presentation will describe the current definition of a proposed new facility called MaRIE at Los Alamos National Laboratory. The concept is of decadal scope and is predicated on the collocation of a fourth-generation X-ray light source with a proton accelerator spallation neutron source and complementary synthesis and characterization capabilities. MaRIE is an acronym which stands for Matter-Radiation Interactions in Extremes. The facility has been conceived partly in response to the increasing role that control science is expected to play in materials research compared to observation science. If new materials are to be implemented in a timely fashion for the most aggressive conditions of proposed fission and fusion energy applications they will have to rely, at least in part, on models, simulations and scientific insight. Validation of these models will require measurements at spatial and temporal scales that have only recently become enabled by the latest generations of light sources. A hallmark of the MaRIE concept is an emphasis on in situ studies (under extreme neutron, photon and ion irradiation conditions) of the phenomena that lead to swelling, phase transformations, thermal properties and corrosion. Insights and data, relevant to atomistic and quantum mechanical models, are major goals, as well as the facilitation of rapid materials discovery. It is hoped that this presentation will solicit input on aspects of the facility definition that should be strengthened or diminished to meet the needs of the fission community. (authors)

The monster within: Mary Shelley's Frankenstein and a patient's fears of childbirth and mothering.

Science.gov (United States)

Almond, B R

1998-08-01

This paper explores the fantasy, widespread among women, of giving birth to a monster, particularly a psychological monster. The author hypothesises two central intrapsychic issues underlying these fears: monsters are viewed as 'incest babies' or as reflections of maternal aggression--evil, destructive parts of the mother passed on to the infant. Shame about femaleness is postulated as a third factor in the fear of producing something monstrous. Mary Shelley's novel, 'Frankenstein', is an iconic literary representation of these themes. The author presents and discusses some psychobiographical material about Mary Shelley, speculating on her motives for writing this novel and tracing the intrapsychic concerns about incest and aggression as reflected in the novel itself. Some recent feminist and psychoanalytic critical readings of 'Frankenstein' are referenced as they reflect on the novel's concern with themes of female sexuality and procreation. Clinical material from the author's own practice is presented to illustrate these fears, so similar to those with which Mary Shelley was dealing. A discussion, citing some relevant literature, follows.

Marie Nimier, au cœur du silence

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Joëlle Papillon

2012-01-01

Full Text Available Dans La Reine du silence, Marie Nimier se confronte à la figure de son père, l’écrivain Roger Nimier, mort lorsqu’elle avait cinq ans. Elle y montre le poids qui pèse sur l’enfant d’écrivain, mais aussi celui de l’héritage du secret familial et de l’injonction au silence. La difficulté de l’élaboration de son récit de filiation se révèle dans les constants recommencements et reformulations, qui constituent la marque de la tension angoissante entre l’obligation de dire et celle de taire. In La Reine du silence, Marie Nimier confronts her father’s memory – the writer Roger Nimier, who died when she was five years old. The novel describes the burden of being a writer’s child, along with that of inheriting family secrets and submitting to a code of silence. The difficulty of recounting her relationship with her late father is evidenced by the narrator’s numerous “false starts” and her constant rewritings. The hesitant nature of the narration captures an anguish born of two irreconcilable obligations : the need to put things into words and the pressure to remain silent.

Angles of Refraction: The Letters of Mary Delany

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Eleonora Chiavetta

2014-04-01

Full Text Available Mary Delany (1700-1788 is particularly famous for her paper-cuttings or ‘mosaicks’ based on botanical subjects. A very lively woman of fashion, she was close to Queen Charlotte and one of the Bluestocking Ladies. She left a vivid portrait of life and society in eighteenth century England and Ireland in the six volumes of her Autobiography and Letters, edited in 1861 by her descendant Lady Llanover. Her autobiography is made up of 18 letters sent to her most intimate friend, Margaret Cavendish, Duchess of Portland. The first letter is dated 1740, but in this, as in the following ones, Mrs. Delany narrates her past life to her friend, starting from the early years of her life, describing her unhappy marriage, financial difficulties as a widow, and family relationships. Along with these ‘autobiographical’ letters, other letters written by her to her sister Ann are introduced, which date to the periods of life Mrs. Delany is dealing with. The aim of this paper is to focus on the textual, linguistic and content differences between the two letter types, and analyse how the identity of Mary Delany is differently constructed and perceived in the explicit autobiographical letters addressed to the Duchess of Portland, and the ones written to her sister. 

Je vous salue Marie de Jean-Luc Godard : modalités et enjeux d’un retour du religieux au cinéma “Hail Mary, full of grace”, a film by Jean-Luc Godard

Directory of Open Access Journals (Sweden)

Natalie Malabre

2012-06-01

Full Text Available Est-il possible de filmer un sujet aussi sensible que celui de la virginité de Marie en dehors des références aux canons religieux ? Ce fut le défi de Jean-Luc Godard au milieu des années 1980, lorsqu’il réalisa Je vous salue Marie. Sans surprise, certains catholiques manifestèrent leur opposition. Mais d’autres essayèrent d’expliquer et de soutenir cette manière non traditionnelle d’approcher le mystère de la transcendance.Is it possible to film religious subject, a very sensitive one like the virginity of Mary, out of the references of religious stances? That was the challenge of Jean-Luc Godard in the middle of the 80’s when he promoted “Je vous salue Marie”. Without surprise, some Catholics demonstrated their opposition. But some of them tried to explain and support the untraditional way to approach the mystery of transcendence.

2005 dossier. ANDRA's researches on the geological disposal of high-level and long-lived radioactive wastes. Results and perspectives; Dossier 2005. Les recherches de l'Andra sur le stockage geologique des dechets radioactifs a haute activite et a vie longue. Resultats et perspectives

Energy Technology Data Exchange (ETDEWEB)

NONE

2005-06-15

This document makes a status of the researches carried out by the French national agency of radioactive wastes (ANDRA) about the geologic disposal of high-level and long-lived radioactive wastes in deep geologic formations (argilites and granites). Content: 1 - Research on deep disposal of radioactive waste: general interest task: Legislative framework, ANDRA scientific objectives, Inspections and assessments; 2 - Designing a safe and reversible disposal system: Repository safety, Reversibility: an essential requirement; 3 - Clay Research on a repository in a clay formation, A long research programme, Dossier 2005 Argile; 4 - Meuse/Haute-Marne site clay: Expected properties of the rock formation, Choice of argillite, Meuse/Haute-Marne site, Conclusions from 10 years of research at the Meuse/Haute-Marne site; 5 - Repository installations: Safe and reversible architecture, Disposal of B waste, Disposal of C waste, Possible disposal of spent fuel (CU); 6 - The disposal facility in operation: From waste packages reception to their disposal in cells, Stages of the progressive closure of engineered structures; 7 - Reversible management: Freedom of choice for future generations, Various closure stages; 8 - Long-term evolution of the repository: Apprehending the repository complexity Main evolutions expected, Slow and limited release of radioactive substances; 9 - Repository safety and impact on man: Several evolution scenarios, Normal evolution, Altered evolution; 10 - Granite Research on a repository in a granite formation: A global approach, Scientific co-operations, Dossier 2005 Granite; 11 - Characteristics of French granite formations: What properties are required for a repository?, Different types of granite formations; 12 - Repository installations: Repository design adapted to granite fractures, Clay seals to prevent water flows, Waste disposal packages ensuring long-term leak-tightness, Physical and chemical environment favourable for waste packages, Architecture

ON THE CULT OF MARY OF DANIEL ZIELIŃSKI IN THE LIGHT OF THE "PREFACE" TO "SZATA WZORZYSTA DOSKONAŁOŚCI" (1649

Directory of Open Access Journals (Sweden)

Katarzyna Kaczor-Scheitler

2017-10-01

Full Text Available This article presents the issues tackled in the “Preface” to "Szata wzorzysta doskonałości, zakonnicę w oczach Boskich zdobiąca i wszelkim stanom ludzi żyć duchownie pragnących pożyteczna" ("The Patterned Robe of Perfection Worn by the Nun before the Eyes of God and Useful to All People Wishing to Lead a Spiritual Life" (Kraków 1649 by Daniel Zieliński, a Bernadine from Alwernia. Noteworthy in this work, orientated toward awakening prayer activity and promoting religious life, is the dedication to Mary, which constitutes an expression of the tribute to Mary made by the author as well as a testimony of his personal experience. The article shows that the “Preface” was written for the purpose of the cult of Mary and constitutes a testimony of the spirituality of the post-tridentine era. The author also reflected on the cult of Mary in Polish Catholicism, as manifested in the christenings, scapulars and rosaries, Marian Sodalities, the increasing role of sanctuaries to Mary (including Jasna Góra, Kalwaria Zebrzydowska and the related pilgrimage movement. The cult of Mary was spread through prayer books, sermons, religious poetry and devotional books.

Lin- CD34hi CD117int/hi FcεRI+ cells in human blood constitute a rare population of mast cell progenitors.

Science.gov (United States)

Dahlin, Joakim S; Malinovschi, Andrei; Öhrvik, Helena; Sandelin, Martin; Janson, Christer; Alving, Kjell; Hallgren, Jenny

2016-01-28

Mast cells are rare tissue-resident immune cells that are involved in allergic reactions, and their numbers are increased in the lungs of asthmatics. Murine lung mast cells arise from committed bone marrow-derived progenitors that enter the blood circulation, migrate through the pulmonary endothelium, and mature in the tissue. In humans, mast cells can be cultured from multipotent CD34(+) progenitor cells. However, a population of distinct precursor cells that give rise to mast cells has remained undiscovered. To our knowledge, this is the first report of human lineage-negative (Lin(-)) CD34(hi) CD117(int/hi) FcεRI(+) progenitor cells, which represented only 0.0053% of the isolated blood cells in healthy individuals. These cells expressed integrin β7 and developed a mast cell-like phenotype, although with a slow cell division capacity in vitro. Isolated Lin(-) CD34(hi) CD117(int/hi) FcεRI(+) blood cells had an immature mast cell-like appearance and expressed high levels of many mast cell-related genes as compared with human blood basophils in whole-transcriptome microarray analyses. Furthermore, serglycin, tryptase, and carboxypeptidase A messenger RNA transcripts were detected by quantitative reverse transcription-polymerase chain reaction. Altogether, we propose that the Lin(-) CD34(hi) CD117(int/hi) FcεRI(+) blood cells are closely related to human tissue mast cells and likely constitute an immediate precursor population, which can give rise to predominantly mast cells. Furthermore, asthmatics with reduced lung function had a higher frequency of Lin(-) CD34(hi) CD117(int/hi) FcεRI(+) blood mast cell progenitors than asthmatics with normal lung function. © 2016 by The American Society of Hematology.

Initial results on computational performance of Intel Many Integrated Core (MIC) architecture: implementation of the Weather and Research Forecasting (WRF) Purdue-Lin microphysics scheme

Science.gov (United States)

Mielikainen, Jarno; Huang, Bormin; Huang, Allen H.

2014-10-01

Purdue-Lin scheme is a relatively sophisticated microphysics scheme in the Weather Research and Forecasting (WRF) model. The scheme includes six classes of hydro meteors: water vapor, cloud water, raid, cloud ice, snow and graupel. The scheme is very suitable for massively parallel computation as there are no interactions among horizontal grid points. In this paper, we accelerate the Purdue Lin scheme using Intel Many Integrated Core Architecture (MIC) hardware. The Intel Xeon Phi is a high performance coprocessor consists of up to 61 cores. The Xeon Phi is connected to a CPU via the PCI Express (PICe) bus. In this paper, we will discuss in detail the code optimization issues encountered while tuning the Purdue-Lin microphysics Fortran code for Xeon Phi. In particularly, getting a good performance required utilizing multiple cores, the wide vector operations and make efficient use of memory. The results show that the optimizations improved performance of the original code on Xeon Phi 5110P by a factor of 4.2x. Furthermore, the same optimizations improved performance on Intel Xeon E5-2603 CPU by a factor of 1.2x compared to the original code.

Maris polarization in neutron-rich nuclei

Directory of Open Access Journals (Sweden)

Shubhchintak

2018-03-01

Full Text Available We present a theoretical study of the Maris polarization effect and its application in quasi-free reactions to assess information on the structure of exotic nuclei. In particular, we explore the dependence of the polarization effect on neutron excess and neutron-skin thickness. We discuss the uncertainties in the calculations of triple differential cross sections and of analyzing powers due the choices of various nucleon–nucleon interactions and optical potentials and the limitations of the method. Our study implies that polarization variables in (p, 2p reactions in inverse kinematics can be an effective probe of single-particle structure of nuclei in radioactive-beam facilities.

Maris polarization in neutron-rich nuclei

Science.gov (United States)

Shubhchintak; Bertulani, C. A.; Aumann, T.

2018-03-01

We present a theoretical study of the Maris polarization effect and its application in quasi-free reactions to assess information on the structure of exotic nuclei. In particular, we explore the dependence of the polarization effect on neutron excess and neutron-skin thickness. We discuss the uncertainties in the calculations of triple differential cross sections and of analyzing powers due the choices of various nucleon-nucleon interactions and optical potentials and the limitations of the method. Our study implies that polarization variables in (p, 2p) reactions in inverse kinematics can be an effective probe of single-particle structure of nuclei in radioactive-beam facilities.

Marie Underi ühe luuletuse ümber / August Eelmäe

Index Scriptorium Estoniae

Eelmäe, August, 1931-

2003-01-01

Marie Underi luuletusest "Me ootame" ja selle vaheredaktsioonist, avaldatud pealkirjaga "Üks päev" (Oma Maa, 1947, nr. 2). Ilmunud ka kogumikus: Eelmäe, August. Kõned ja kirjatööd. Tallinn : Underi ja Tuglase Kirjanduskeskus, 2006, lk. 56-71

Mari Koger : avatud magamistoaga korter pööningukorrusel / Gitte Hint

Index Scriptorium Estoniae

Hint, Gitte

2003-01-01

Korter Nõmmel renoveeritud puumajas (arhitekt Hannes Niineväli). Sisearhitekt Mari Koger, tema kommentaarid. Söögilaua alumiiniumist valatud jalgade autor on Taavi Aunre. Söögilauda valgustab Alberto Meda ja Paolo Rizzatto disainitud lamp Titania. Ill.: plaan, 8 värv. vaadet

The life and legacy of Marie Curie.

OpenAIRE

Rockwell, Sara

2003-01-01

Marie Curie was a remarkable woman whose discoveries broke new ground in physics and chemistry and also opened the door for advances in engineering, biology, and medicine. She broke new ground for women in science: she was, for example, the first woman to receive a doctor of science degree in France, the first woman to win Nobel Prize, the first woman to lecture at the Sorbonne, the first person to win two Nobel Prizes, and the first Nobel Laureate whose child also won a Nobel Prize. Her life...

Üleväärsusest / Jan Kaus

Index Scriptorium Estoniae

Kaus, Jan, 1971-

2005-01-01

Vastukaja art.: Raid, Juku-Kalle. Alla mõistuse! // Postimees. - (2005/Sep/29) - Lk. 21. Artikli kaasautorid on Toomas Kümmel ja Sven Kivisildnik. Vt ka vastukaja: Rein Veidemann. Häda mõistuse pärast, Postimees, 3. okt., lk. 17

XAS studies of the effectiveness of iron chelating treatments of Mary Rose timbers

International Nuclear Information System (INIS)

Berko, A; Schofield, E J; Chadwick, A V; Smith, A D; Jones, A M; Mosselmans, J F W

2009-01-01

The oxidation of sulfur in marine archaeological timbers under museum storage conditions is a recently identified problem, particularly for major artefacts such as historic ships excavated from the seabed. Recent work on the Vasa has stressed the role of iron in catalysing the oxidative degradation of the wood cellulose and the polyethylene glycols used to restore mechanical integrity to the timbers. In developing new treatment protocols for the long term preservation of Henry VIII of England's flagship, the Mary Rose, we are investigating the potential of chelating agents to neutralise and remove the iron products from the ships timbers. We have explored the use of aqueous solutions of chelating agents of calcium phytate, ethylenediaminetetraacetic acid (EDTA), diethylenetriaminepentaacetic acid (DTPA) and ammonium citrate to extract the iron compounds. All of these solutions exhibit some level of iron removal; however the key is to find the most effective concentration at pH of around 7 of the reagent solution, to minimise the treatment time and find the most cost-effective treatment for the whole of the Mary Rose hull. Fe K-edge XAFS data from samples of Mary Rose timbers, before and after treatment by the chelating agents mentioned has been collected. The data collected provide valuable insights into the effectiveness of the treatment solutions.

Nanos promotes epigenetic reprograming of the germline by down-regulation of the THAP transcription factor LIN-15B.

Science.gov (United States)

Lee, Chih-Yung Sean; Lu, Tu; Seydoux, Geraldine

2017-11-07

Nanos RNA-binding proteins are required for germline development in metazoans, but the underlying mechanisms remain poorly understood. We have profiled the transcriptome of primordial germ cells (PGCs) lacking the nanos homologs nos-1 and nos-2 in C. elegans. nos-1nos-2 PGCs fail to silence hundreds of transcripts normally expressed in oocytes. We find that this misregulation is due to both delayed turnover of maternal transcripts and inappropriate transcriptional activation. The latter appears to be an indirect consequence of delayed turnover of the maternally-inherited transcription factor LIN-15B, a synMuvB class transcription factor known to antagonize PRC2 activity. PRC2 is required for chromatin reprogramming in the germline, and the transcriptome of PGCs lacking PRC2 resembles that of nos-1nos-2 PGCs. Loss of maternal LIN-15B restores fertility to nos-1nos-2 mutants. These findings suggest that Nanos promotes germ cell fate by downregulating maternal RNAs and proteins that would otherwise interfere with PRC2-dependent reprogramming of PGC chromatin.

The underground geothermal resource about Bure is not exceptional. Answers by the ANDRA to critics made by associations on the geothermal resource in the Cigeo study area

International Nuclear Information System (INIS)

Martin, Marc-Antoine

2013-01-01

As some documents published by associations stated that the site chosen for Cigeo (Industrial centre for geological storage of nuclear materials and wastes) could be a geothermal resource of interest, the ANDRA herein states again that this resource is neither exceptional nor attractive in the present technological and economical conditions. In order to precisely answer to the arguments stated by the associations, it notably refers to some drillings performed in this area. It discusses drilling conditions and tests, test result interpretation, measurements, the process transparency, and the actual assessment of geothermal resources

Spécificité pastorale de la personnalité de Jean-Paul II selon Jean-Marie Lustiger

Directory of Open Access Journals (Sweden)

Ryszard Biernat

2011-04-01

Full Text Available Jean-Marie Lustiger admired John Paul II and he was devoted to him. They both had similar origin. The Cardinal of Paris often accompanied the pope in his pastoral visits. He perceived John Paul II as the man of Providence. He was convinced that God had prepared him to this role. Jean-Marie Lustiger emphasized the attitudes of John Paul II that attracted the attention and admiration of observers. For instance: pray, holiness, attentive pastor and good relation with young people. Jean-Marie Lustiger as an attentive observer also focused his attention on the pastoral methods of John Paul II. In his utterances he often perceived the following methods: each person was important, defense of person’s dignity, the ability to speak with each man, modern language, importance of the pastoral visits and sui generis spiritual pedagogic. Jean-Marie Lustiger noticed radical change of perspective in preaching and in pastoral action of John Paul II. According to him the pope perceived the challenges of the modern times, evaluated needs of the humanity and gave the appropriate answers. For these he did not choose politics, sociology or even anthropology as a re fl ection but addressed to the hurt human who was redeem by Jesus Christ.

Dr. Mary McLeod Bethune: A Life Devoted to Service

Science.gov (United States)

Long, Kim Cliett

2011-01-01

The purpose of this paper is to explore and analyze the leadership traits of Dr. Mary McLeod Bethune, an African-American woman of history, using the servant leadership theory developed by Robert K. Greenberg and the ten characteristics of servant leadership as conceived by Larry C. Spears. This exploration seeks to identify the significant…

Flood-inundation maps for the St. Marys River at Decatur, Indiana

Science.gov (United States)

Strauch, Kellan R.

2015-08-24

Digital flood-inundation maps for an 8.9-mile reach of the St. Marys River at Decatur, Indiana, were developed by the U.S. Geological Survey (USGS), in cooperation with the Indiana Office of Community and Rural Affairs. The inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site (http://water.usgs.gov/osw/flood_inundation/), depict estimates of the areal extent and depth of flooding corresponding to selected water levels (stages) of the St. Marys River at Decatur (USGS station number 04181500). The maps are useful for estimating near-real-time areas of inundation by referencing concurrent USGS streamgage information at http://waterdata.usgs.gov/. In addition, the streamgage information was provided to the National Weather Service (NWS) for incorporation into their Advanced Hydrologic Prediction Service flood warning system (http:/water.weather.gov/ahps/). NWS-forecasted peak-stage information may be used in conjunction with the maps developed during this study to show predicted areas of flood inundation.

Romanticism or Reality? An Exploration of Frances Mary Hendry's "Chandra."

Science.gov (United States)

Johnson, Jilaine

This paper singles out a novel written for children about India, "Chandra" (1995) by Frances Mary Hendry, as a powerful and useful novel to present to today's 11 to 14 year old students. The paper contends that the novel allows students to explore and consider different value systems, challenges them to become aware of prejudice and the…

Keelatud kanep mõjub ohutumalt kui seadustatud alkohol ja tubakas / Mari Järvelaid

Index Scriptorium Estoniae

Järvelaid, Mari, 1956-

2009-01-01

Meditsiiniteaduste doktor kirjeldab kanepi teaduslikult uuritud toimeid ja leiab, et kanepi võiks Eestis legaliseerida küll. Lisa: kanepi tarvitamisega tekkivad sümptomid ; Mari Järvelaidi viis soovitust kanepitarvitajale

The light of the word in Ljubica Marić's music

Directory of Open Access Journals (Sweden)

Makević Zorica

2009-01-01

Full Text Available Ljubica Marić's music provides manifold encouragements for consideration in the light of the Logos, according to the teaching exposed in the prologue of the Gospel by St. John. It speaks of the essential inconceivability of time and life, which have their cause in God and His Logos. Seeing through and praising 'the logos of things' guide all its aspects: the tone reveals itself as a vibration, as the energy of lasting and existing, as the beginning of every time and motion; the sonority of different instrumental media is freely expressed and mutually determined in co-action with specific musical and contextual moments; the rhythm evades every regularity and mechanicalness, by which both single duration's and the whole metro-rhythmic course gain a vivid expression. The entire shape of the work is also taken from the reality of psychological and historical time, from its unreductable dynamics, being always in a vivid connection with the space, origin and tradition. The respect for 'the truth of things', the awe before the mystery of time and existence, which call upon the very principle of life in the divine Logos are obvious in everything. Designation of man as a being of light and reason created in the image of God to be the likeness of His being, is expressed in Ljubica Marić's music by the measure of human pulse taken as the basic tempo of her entire opus. Ljubica Marić expressed her consciousness of the reason as a special gift to the man by extremely careful treatment of the words - its meanings, melodies, rhythms, which she always considered the very source of music. The relation between the word and the voice - its sonorous body - is shown in the cantata Songs of Space (1956 as a mystery of the encounter of the Logos and the matter. In relation to her earlier works, this one is a marked breakthrough of the composer's authentic 'voice', which will find its full identity only after receiving the divine Word, symbolized by the melodies of

Charcot-Marie-Tooth disease complicating type 2 diabetes.

LENUS (Irish Health Repository)

Win, Htet Htet Ne

2012-02-01

Although both conditions are relatively common, there are very few descriptions of type 2 diabetes mellitus coexisting with Charcot-Marie-Tooth disease (CMT). This case report and literature review describes a 53-year-old Irish man who presented with type 2 diabetes and significant neuropathy, and who was subsequently diagnosed with CMT type 1A. This case report will also discuss how to differentiate diabetic neuropathy from a progressive hereditary neuropathy and how coexistence aggravates the progression of neuropathy thus necessitating early diagnosis.

Charcot-marie-tooth disease complicating type 2 diabetes.

LENUS (Irish Health Repository)

Win, Htet Htet Ne

2011-07-01

Although both conditions are relatively common, there are very few descriptions of type 2 diabetes mellitus coexisting with Charcot-Marie-Tooth disease (CMT). This case report and literature review describes a 53-year-old Irish man who presented with type 2 diabetes and significant neuropathy, and who was subsequently diagnosed with CMT type 1A. This case report will also discuss how to differentiate diabetic neuropathy from a progressive hereditary neuropathy and how coexistence aggravates the progression of neuropathy thus necessitating early diagnosis.

Marie Curie - science was her life

International Nuclear Information System (INIS)

Wolschendorf, K.

1998-01-01

In this paper a short survey of the life and the work of Marie Curie is presented. She was born in 1867 in Warsaw/Poland and went to Paris in 1891 to study physics, mathematics, and chemistry. In 1895 the married the physicist Pierre Curie, and together they began research work on radioactivity. For her doctorate she investigated various radiating substances and discovered the radioactive element Radium in 1898. She was awarded the Nobel Prize in Physics in 1903, and later on the Nobel Prize in Chemistry in 1911 for performing pioneering studies with radium and contributing profoundly to the understanding of radioactivity. In 1934 she died in a health resort due to leukemia. (orig.) [de

Uned, mida mujal ei näe / Heilika Võsu ; interv. Mari Laaniste

Index Scriptorium Estoniae

Võsu, Heilika

2007-01-01

PÖFFi animafilmide festivali "Animated Dreams" (21.-25. XI kinos Sõprus), mis on seekord pühendatud Nukufilmi 50. juubelile, tutvustab festivali peakorraldaja. Võistluskavas on Eestist Kaspar Jancise "Maraton" ja Mari-Liis Bassovskaja - Jelena Girlini "Kleit". Lisatud festivali kava

Tarvo Hanno Varres, Mari-Leen Kiipli / Merilin Talumaa, Hanno Soans, Tatjana Kozlova-Johannes

Index Scriptorium Estoniae

Talumaa, Merilin, 1986-

2015-01-01

Vaatluse alla on võetud Tarvo Hanno Varrese heli- ja videoinstallatsioon "Lindistav põrand" (2015) ja heli- ja videoteos "Betweenland" (2014) ning Mari-Leen Kiipli fotoseeria "The school of dreams" (2012-2015)

Strange bedfellows: Cervantes and Mary Wollstonecraft Shelley

Directory of Open Access Journals (Sweden)

Alfredo Moro

2017-11-01

Full Text Available Miguel de Cervantes and Mary Shelley do seem, at first sight, two strange bedfellows. Notwithstanding the evident differences between the narrative of both authors, the English novelist showed a notable interest for the life and works of Miguel de Cervantes throughout her literary career. This article intends to offer a precise portrait of the Cervantean interests of the author of Frankenstein, tracing these through her personal correspondence, her narrative production, and finally, through her contribution to the realm of Cervantean studies: Shelley’s Life of Cervantes (1837, published in Dyonisius Lardner’s Cabinet Cyclopaedia.

Traitement statistique des distorsions non-linéaires pour la restauration des enregistrements sonores.

OpenAIRE

Picard , Guillaume

2006-01-01

L'objet de la thèse est l'étude, la modélisation et le traitement des distorsions non linéaires sonores, pour lesquelles les techniques actuelles s'avèrent impuissantes. L'approche retenue consiste à représenter, globalement, à la fois le signal audio à restaurer et le processus de distorsion, dans le cadre d'un modèle statistique. Cette approche présente un bon compromis entre une souhaitable généricité -possibilité de traiter à l'aide d'une méthode globale plusieurs types de distorsions- et...

Mart ja Mari-Ann Susi taotlevad omanikena Concordia pankrotti / Andri Maimets

Index Scriptorium Estoniae

Maimets, Andri

2003-01-01

Concordia Ülikooli rektori kohast loobunud Mart Susi ning prorektori ametikohalt lahkunud Mari-Ann Susi taotlevad neile kuuluvat ülikooli pidanud miljonivõlgades firma pankrotti. Hiljuti loodi õppejõududest, tudengitest js töötajatest mittetulundusühing Concordia Akadeemiline Ühisus (CAU), selle nõukogu esimees on Hagi Šein

Walt Disney Meets Mary Daly: Invention, Imagination, and the Construction of Community.

Science.gov (United States)

Covino, William A.

2000-01-01

Posits Walt Disney as an influential sorcerer in the process of integrating the real world into Disney's synthetic universe, and Mary Daly's work "Wickedary" as a work that constructs an alternative "magic kingdom" through an insistence on an anti-patriarchal lexicon. (NH)

Rediscovering the Art of Developmental Therapy: An Interview with Mary M. Wood

Science.gov (United States)

Teagarden, James M.; Kaff, Marilyn S.; Zabel, Robert H.

2013-01-01

Dr. Mary Margaret Wood is best known for developing psychoeducational programs that integrate mental health and special education interventions for children with emotional and behavioral disorders (EBD). Developmental Therapy (DT) includes comprehensive assessment of student behavior, communication, social, and cognitive development,…

Flower Power: Desire, Gender, and Folk Belief in the Joycean Mary Garden

Directory of Open Access Journals (Sweden)

Christin Mulligan

2017-06-01

Full Text Available Robert Brazeau and Derek Gladwin’s Eco-Joyce (2014 largely overlooks a historical basis for ecocritical thought. The absence of a historicist view requires consideration not only of the natural world but folk botany, such as the Mary Garden that is a phantom presence in A Portrait of the Artist as a Young Man as well as in “Nausicaa” and “Penelope” in Ulysses and Finnegans Wake. The undergrowth of the garden reconfigures human action and subtly predicts it with its compendium of theological and devotional meanings for the burgeoning sexuality expressed by Gerty MacDowell and Issy Earwicker as well as the mature longing of Molly Bloom. This essay will establish a fresh Deleuzian paradigm of Becoming-Flower to demonstrate how the Mary Garden blooms to present new perspectives on Catholicism, eros, and gender identity in Joyce’s major works.

Maria Carolina and Marie Antoinette: Sisters and Queens in the mirror of Jacobin Public Opinion

Directory of Open Access Journals (Sweden)

Cinzia Recca

2014-09-01

Full Text Available Marie Antoinette of Franceand Maria Carolina of Naples, both consorts, contributed to a flourishing of matronage, reproducing conceptions of royal femininity that embraced both the private and public roles they were expected to fulfil. However, while the political role of the first Queen has been largely reconsidered, her sister Maria Carolina has not yet been adjudicated impartially. This is somewhat curious, because Maria Carolina inherited from her sister the same disregard towards the Revolution and this, as perceived by the Jacobins, was duly proposed in their acrimonious criticism of her political role. This paper aims to focus on this criticism, analysing how the charges against Maria Carolina in the post-French revolutionary period, were a political duplication of the Jacobin attacks on Marie Antoinette from 1791 onwards. From this point of view, the paper will focus on the portrait of Maria Carolina in 1793 revolutionary Parisby Giuseppe Gorani, an Italian Jacobin noble. His Mémoires Secrets – where Maria Carolina was represented as a wicked woman in the same terms previously employed to denounce her sister Marie Antoinette by the French Republicans – was well known across Italy. This subject dominated the main pamphlets and brochures published in Naples in 1799, during the brief duration of the Neapolitan Republic, because it legitimised the rebellion against the monarchy. After the fall of the Neapolitan Republic, the political attacks on Maria Carolina continued likewise in France, where many Neapolitan patriots were obliged to flee. Analysing  Giuseppe Gorani’s Mémoires we gather that the portrait of Marie Antoinette’s sister was painted according to the main stereotypes of  French revolutionary political culture.

Geoscientific Data Acquisition and Management System (systeme d'Acquisition et de Gestion des Donnees, S.A.G.D.) of the Andra Meuse / Haute-Marne research center

International Nuclear Information System (INIS)

Tabani, P.; Hermand, G.; Delay, J.; Mangeot, A.

2010-01-01

Document available in extended abstract form only. ANDRA is directly responsible for all scientific data acquired in real time and wire-line at the Meuse Haute- Marne underground research laboratory. To fulfil the needs for the acquisition, storage and display of realtime data, Andra decided to develop and install a system called SAGD (Systeme d'Acquisition et de Gestion des Donnees). With this view, a system was designed to: - Determine the acquisition tools and methods so that technical failures would not result in the loss of data or the acquisition of erroneous data, - Store (conservation) in the long-term all data in a single place in a single form, - Allow the diffusion and free access of data to the large community of ANDRA researchers, partners and service contractors in a single fluid way whatever the source of the data. - Help external communication through a user friendly and easy to understand presentation of the recorded data. S.A.G.D fulfils these objectives by: - Making available in real time, and through a single system, all experimental data under acquisition at the MHM Center and Mont Terri laboratory, - Displaying the recorded data on temporal windows and specific time step, - Allowing remote control of the experimentations, - Ensuring the traceability of all recorded information, - Ensuring data storage in a data base. S.A.G.D has been deployed in the first experimental drift at -445 m in November 2004. It was subsequently extended to the underground Mont Terri laboratory in Switzerland in 2005 and to the entire surface logging network of the Meuse / Haute-Marne Center in 2008. The SAGD computer network is an autonomous network consisting of optical fiber links which transmits experimentation data to the servers and computers in the control room, whether they originate from the bottom of a borehole or surface level. A high speed link between Mont Terri and Bure allows remote control of all the experimentations and the centralization of all

Long-term trends in the St. Marys River open water fish community

Science.gov (United States)

Schaeffer, Jeffrey S.; Fielder, David G.; Godby, Neal; Bowen, Anjanette; O'Connor, Lisa; Parrish, Josh; Greenwood, Susan; Chong, Stephen; Wright, Greg

2011-01-01

We examined trends in species composition and abundance of the St. Marys River fish community. Abundance data were available approximately once every six years from 1975 through 2006, and size and age data were available from 1995 through 2006. We also compared survey data in 2006 with results of a concurrent creel survey that year, as well as data from prior surveys spanning a 69 year time frame. The St. Marys River fish community was best characterized as a coolwater fish community with apparent little variation in species composition, and only slight variation in overall fish abundance since 1975. However, we did find recent trends in abundance among target species sought by anglers: centrarchids increased, percids appeared stable, and both northern pike Esox lucius and cisco Coregonus artedii declined. Survey results suggested that walleye (Sander vitreus) and yellow perch (Perca flavescens) experienced moderate exploitation but benefited from recent strong recruitment and faster growth. Mechanisms underlying declines of northern pike and cisco were not clear; reduced abundance could have resulted from high exploitation, variation in recruitment, or a combination of both factors. Despite these challenges, the St. Marys River fish community appears remarkably stable. We suggest that managers insure that creel surveys occur simultaneously with assessments, but periodic gill net surveys may no longer provide adequate data in support of recent, more complex management objectives. While additional surveys would add costs, more frequent data might ensure sustainability of a unique fish community that supports a large proportion of angler effort on Lake Huron.

Geraldine Reymenants, Marie Elisabeth Belpaire. Gender en macht in het literaire veld 1900-1940

Directory of Open Access Journals (Sweden)

Monica Soeting

2017-02-01

Full Text Available Geraldine Reymenants, Marie Elisabeth Belpaire. Gender en macht in het literaire veld 1900-1940 (kadoc-studies 35; Leuven: Universitaire Pers Leuven, 2013, 288 pp., isbn 9789058679444.

Reduction of EMC Emissions in Mixed Signal Integrated Circuits with Embedded LIN Driver

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P. Hartl

2016-06-01

Full Text Available This paper describes several methods for reduction of electromagnetic emissions (EME of mixed signal integrated circuits (IC. The focus is on the impact that a LIN bus communication block has on a complex IC which contains analog blocks, noisy digital block, micro-core (µC and several types of memories. It is used in an automotive environment, where EMC emission reduction is one of the key success factors. Several proposed methods for EME reduction are described and implemented on three test chips. These methods include current consumption reduction, internal on-chip decoupling, ground separation and different linear voltage regulator topologies. Measurement results of several fabricated test chips are shown and discussed.

Marie-Sklodowska Curie, pioneer of Medical Physics and inspiration for women scientists; Marie-Sklodowska Curie, pionera de la Física Médica y fuente de inspiración para mujeres científi cas

Energy Technology Data Exchange (ETDEWEB)

Martín, G.

2017-11-01

The International Organization for Medical Physics (IOMP) celebrates annually the International Day of Medical Physics (IDMP) for which the 7th November, the birthday of Marie Sklodowska Curie, a most exceptional character in science at all and a pioneer of Medical Physics, has been chosen. This year, the IDMP is devoted to women in Medical Physics to honour the 150th anniversary of Marie Curie’s birthday. This article briefly outlines her outstanding personality, her fundamental discovery of the radioactivity and other scientific achievements for which she was awarded two Nobel Prizes, and her extensive collaboration with industry, far less well known. Finally, a brief review of the fundamental legacy she left the humanity in Medicine, Science and for women scientists is presented. [Spanish] La IOMP (Organización Internacional de Física Médica) celebra cada año el Día Internacional de la Física Médica (IDMP), el 7 de noviembre, en honor al nacimiento de Marie Sklodowska-Curie, un personaje excepcional en la historia de la ciencia y pionera de la Física Médica. Este año, en conmemoración del 150º aniversario de su nacimiento, el IDMP está dedicado a las mujeres en Física Médica. El siguiente artículo sobre Marie Curie describe brevemente su destacada personalidad, su descubrimiento fundamental de la radiactividad y otros logros científicos que la hicieron merecedora de dos Premios Nobel, y su extensa colaboración con la industria, faceta ésta desconocida en general. Finalmente, se hace un breve recorrido por el legado fundamental que dejó a la humanidad en Medicina, en Ciencia y para las mujeres científicas.

Applying a Multiple Screening Program Aided by a Guideline-driven Computerized Decision Support System—A Pilot Experience in Yun-Lin, Taiwan

Directory of Open Access Journals (Sweden)

Jou-Wei Lin

2007-01-01

Conclusion: A computer-aided screening program driven by the US Preventive Services Task Force recommendations has been successfully implemented in Yun-Lin, Taiwan, and provided useful information about local epidemiology and implications for future health policy making. [J Formos Med Assoc 2007; 106(1:58-68

Online Opportunist: Mary Ellen Icaza--Montgomery County Public Libraries, Rockville, MD

Science.gov (United States)

Library Journal, 2004

2004-01-01

When Mary Ellen Icaza became Electronic Services Librarian at Montgomery County Public Libraries, she noticed that the readers' services information on the library web site was invisible, even to librarians. "And if staff can't find it," she says, "customers can't." She set out to help people find that material-and to turn a…

Life as the Middle Child: A Conversation With Mary Margaret Kerr

Science.gov (United States)

Teagarden, James M.; Zabel, Robert H.; Kaff, Marilyn S.

2015-01-01

As part of an ongoing oral history project, a conversation was held with Dr. Mary Margaret Kerr on the past, present, and possible future of the field of providing services to children with emotional-behavioral disorders. Dr. Wood stresses the increasing importance of providing an interdisciplinary approach to meet the needs for children or, as…

An Analysis of the Symptomatic Domains Most Relevant to Charcot Marie Tooth Neuropathy (CMT) Patients

Science.gov (United States)

2017-06-09

Charcot Marie Tooth Disease (CMT); Hereditary Sensory and Motor Neuropathy; Nerve Compression Syndromes; Tooth Diseases; Congenital Abnormalities; Genetic Diseases, Inborn; Heredodegenerative Disorders, Nervous System

A Sinner or a Saint: the image of Mary, Queen of Scots in the works of Friedrich Schiller, Juliusz Słowacki and Stefan Zweig

Directory of Open Access Journals (Sweden)

Melkov Andrey Sergeevich

2017-04-01

Full Text Available The artistic image of Mary, Queen of Scots in the works of F. Schiller, J. Słowacki and S. Zweig are researched in the article. The Queen’s life, character, inner world and psychological portrait appear on the pages of the classicists’ works in the context of the era she lived. The turbulent historical processes that took place in England and Scotland at the end of the Middle Ages and the beginning of the Early Modern Period led to the phenomenon of Mary Stuart’s personality. Obviously the creativity of the authors whose works were dedicated to Mary I of Scotland was influenced by the experience learned from the lessons of their time. It was reflected in the classicists’ analyses and description of the past. Romanticistsof the 19th century, F. Schiller and J. Słowacki, interpreted the personality of Mary Stuart in the sinner/saint dichotomy, but S. Zweig at the historic break in the 30s of the 20th century departed from the unilateralism of such an approach. In his romanced biography of Mary, Queen of Scots he tells about the rises and falls of his heroine. S. Zweig presents Mary I of Scotland as a wonderful, passionate and suffering woman, who even 400 years after her death inspires and excites peoples’ minds and hearts.

Luuleline lõuna Rein Veidemanni moodi: õnn olla koos oma põlvkonnaga / Juune Holvandus

Index Scriptorium Estoniae

Holvandus, Juune

2017-01-01

Rapla keskraamatukogus toimus luulehuviliste kohtumine, kuhu oli lubanud tulla mitmekülgne inimene - kirjandusteadlane, poliitik, ühiskonnategelane, üliõpilastele alati mõistev ja pühendunud õpetaja, nüüd Tallinna Ülikooli prof emeritus, vastne ringhäälingunõukogu esimees Rein Veidemann

Hand involvement in children with Charcot-Marie-Tooth disease type 1A

NARCIS (Netherlands)

Burns, Joshua; Bray, Paula; Cross, Lauren A.; North, Kathryn N.; Ryan, Monique M.; Ouvrier, Robert A.

2008-01-01

Charcot-Marie-Tooth disease type 1A (CMT1A), a demyelinating neuropathy characterised by progressive length-dependent muscle weakness and atrophy, is thought to affect the foot and leg first followed some time later by hand weakness and dysfunction. We aimed to characterise hand Strength, function

Re-Birthing the Monstrous: James Whale's (Mis)Reading of Mary Shelley's "Frankenstein."

Science.gov (United States)

Picart, Caroline Joan S.

1998-01-01

Contributes to scholarship on film and feminism by showing how James Whale's film attempts to excise or severely delimit the disturbing critique of the Romantic politics of gender in Mary Shelley's novel "Frankenstein." Discusses parthenogenesis, showing how the novel critiques the Romantic rhetorical reconstructions of masculine…

Costume Cinema and Materiality Telling the Story of Marie Antoinette through Dress

Directory of Open Access Journals (Sweden)

Therése Andersson

2011-04-01

Full Text Available In ‘Costume Cinema and Materiality: Telling the Story of Marie Antoinette through Dress’ a materiality-based approach for analysing film narratives through costumes is examined. Sofia Coppola’s film Marie Antoinette (2006 serves as the empirical starting point and the theme of dressing and redressing is pursued throughout the film, crystallizing costume as a significant feature for reading the movie. The article argues that costumes, on a symbolic level, work as agents. It thus focuses on the interdependence between costume and interpretations of the screenplay’s main character. A theoretical notion of costumes and materiality is explored, and the idea is further developed in relation to stylistics constituted as emotions materialised in costume. As costumes are the main object for analysis, the discussion immediately centres on costumes produced by professional costume designers for the two-dimensional format of the film frame. In other words, costumes made for the moment: for a specific narrative and aesthetic expression.

Factors affecting groundwater quality at the rehabilitated Mary Kathleen Tailings Dam, Australia

International Nuclear Information System (INIS)

Ward, T.A.; Hart, K.P.; Morton, W.H.; Levins, D.M.

1984-01-01

The Mary Kathleen uranium mine and treatment plant ceased operation in late 1982 and a plan for the closure and rehabilitation of the area was developed by Mary Kathleen Uranium Ltd in association with consultants. This paper describes some of the groundwater quality studies undertaken in support of the rehabilitation program including sampling within the tailings dam to determine the profile of radionuclides, accelerated leaching tests on tailings to estimate long-term release rates of radium, monitoring of piezometers to determine the rate of movement of contaminants, and disposal of acidic effluent by neutralization and ion exchange through infiltration trenches. From accelerated leaching tests, it is estimated that a maximum of 0.13% of 226 Ra will be leached from the tailings in the first 1,000 years. There is no evidence that uranium or any of its daughters is moving away from the waste disposal area. The movement of heavy metals, radionuclides and acidity is strongly retarded by the alkaline soils

Taking Stock: Marie Nimier’s Textual Cabinet of Curiosities

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Adrienne Angelo

2014-01-01

Full Text Available In many life-writing projects, the seemingly innocuous description of heteroclite objects and how those objects are stored and recalled in fact plays an important role in demonstrating their importance to the process of memory work. At once the lingering traces of one’s past and also an aggregation of stories evoked by an examination of them, these curios focus attention on the relationship between the individual and the storage of memories. This article will focus on certain collectibles, collections and collectors that appear throughout the fictional, autobiographical and autofictional world that Marie Nimier has scripted to date. This textual cabinet of curiosities and the act of collecting more generally serve as a trope to connect memory with materiality, despite the numerous narrative voices that Nimier assumes—voices that move from a first-person “Marie Nimier” to an unnamed, although clearly identifiable first-person and even float between genders. Despite this nominal and narrational fluidity, objects function to guarantee recognition, both for the reader, and, especially, for the author herself. What is at stake in this intertextual assemblage of objects is not only the roles that they play in allowing the narrator to revisit past traumas and loss, but also in connecting the author’s presence to other, more fictionalized voices that above all signify the primacy of life-writing in her corpus.

Strangers and Orphans: Knowledge and Mutuality in Mary Shelley's "Frankenstein"

Science.gov (United States)

Gomez, Claudia Rozas

2013-01-01

Paulo Freire consistently upheld humanization and mutuality as educational ideals. This article argues that conceptualizations of knowledge and how knowledge is sought and produced play a role in fostering humanization and mutuality in educational contexts. Drawing on Mary Shelley's novel "Frankenstein," this article focuses on the…

Two cases of bovine hypertrophic osteopathy (Marie-Bamberger's disease)

International Nuclear Information System (INIS)

Ravary, B.; Fecteau, G.

2002-01-01

Two cattle were presented with persistent lameness and Marie-Bamberger's disease was suspected because of the generalised deformity of the distal limbs. The diagnosis was confirmed after further tests (radiography, post-mortem and anatomopathological examinations). The first case was probably caused by a pulmonary infection. The cause of the second case could not be fully determined. The bony lesions characteristic of this condition result from stimulation of the osteogenic layer of the periosteum, and results from neoplasic lesions, pulmonary abscesses, bronchopneumonia, etc [it

Creating an Online Exhibit in a First-Year Seminar: “Luxury Objects in the Age of Marie Antoinette”

Directory of Open Access Journals (Sweden)

Janie Vanpée

2013-04-01

Full Text Available How can students arrive at a closer understanding of the material culture that shaped the lives of the French aristocracy and nascent bourgeoisie of late eighteenth-century France? This is one of the challenges that students face in the first-year seminar, Re-Membering Marie Antoinette, as they study the multiple and conflicting ways that Marie Antoinette was and has been represented in biographies, portraits, memoirs, fiction, film, fashion, plays and pornographic pamphlets, records of her trial in 1793, and the spaces and activies that shaped her daily life. This article focuses on a series of scaffolded assignments that lead students to imagine what Marie Antoinette’s daily life might have been like by exploring the material culture of the period through the objects, decor, and activities depicted in Moreau le Jeune’s series of engravings, Le Monument du Costume, and the craftsmanship, labor, and social practices they entail as described in Diderot and d’Alembert’s Encyclopédie.

Ring peale kultuurkapitali kirjanduslaureaatidele

Index Scriptorium Estoniae

2005-01-01

Eesti Kultuurkapitali 2004. aasta kirjanduse aastapreemia laureaatide teoste tutvustused: André Trinity (Rein Raud "Hector ja Bernard"), Mart Velsker (fs - luulekogu "2004"), Katrin Ruus (Mart Kivastik -näidend "Külmetava kunstniku portree"), Krista Kumberg (Jaan Rannap "Nelja nimega koer"), Rein Veidemann (Toomas Haug "Troojamäe tõotus")

The ties that bind: Soil surveyor William Edgar Tharp and oceanographic cartographer Marie Tharp

Science.gov (United States)

Landa, Edward R.

The link between soil science and geology is personified in the American father and daughter: soil surveyor William Edgar Tharp (1870-1959) and oceanographic cartographer Marie Tharp (1920-2006). From 1904 to 1935, W.E. Tharp mapped soils in 14 states for the US Department of Agriculture, and campaigned during the late 1920s-early 1930s to raise awareness of the high rates of soil erosion from croplands. The lifestyle of the federal soil surveyor in the United States during the early 20th century involved frequent household moves, and it played a formative role in Marie Tharp’s childhood. Her path to a career in geology was molded by this family experience, by mentors encountered in the classroom, and by social barriers that faced women scientists of that era.

Uus nobelist : prantslane Jean-Marie Gustave Le Clézio / Kaarel Kressa

Index Scriptorium Estoniae

Kressa, Kaarel, 1983-

2008-01-01

Nobeli kirjandusauhind 2008 - prantsuse romaanikirjanik Jean-Marie Gustave Le Clézio. Sisaldab autori eesti keelde tõlgitud teoste annotatsioone: Päev, mil Beaumont tegi tutvust oma valuga : [novell] / tlk. Merike Riives (kogumikust Prantsuse novell, 1973); Kõrb / tlk. Kristiina Ross (Eesti Raamat, 1990); Diego ja Frida / tlk. Sirje Keevallik (Kunst, 2007)

ANDRA - National Radioactive Waste Management Agency. Activity report 2009 - Managing today to prepare for tomorrow. Management report and financial statements at December 31, 2009. Annual Sustainable Development Report 2009

International Nuclear Information System (INIS)

2010-01-01

Created in 1979 within the CEA, the National Radioactive Waste Management Agency (ANDRA) was established by the December 1991 Waste Act as a public body in charge of the long-term management of all radioactive waste, under the supervision of the Ministry of Ecology, Energy, Sustainable Development and the Sea (formerly the Ministry of Industry and the Ministry of Environment), and the Ministry of Research. Its 3 basic missions were extended and their funding secured through the 2006 Planning Act: - a R and D mission to propose safe long-term solution for radioactive waste without current disposal system; this mission includes long-term storage, since the 2006 Planning Act, in order to propose interim solutions while final ones are being studied; - an industrial mission concerning, on one hand, waste acceptance criteria and control and, on the other hand, siting, construction, operation, closure and monitoring of repositories. This mission includes as well a public service mission in terms of i) collection of waste of the 'small-scale nuclear activities' producers or owners (including the so-called 'household' radioactive waste, i.e. waste owned by private individuals) and ii) clean-up and rehabilitation of orphan polluted sites; - an information mission, notably through the regular publication of the National Inventory of radioactive materials and waste. This mission includes as well an active policy of dialogue with stakeholders both at national and local level. This document is the activity report, with the management and financial statements report, and the Sustainable Development Report of the Andra for the year 2009

Rapport de frais de 2017-2018 pour Mary Anne Chambers | CRDI ...

International Development Research Centre (IDRC) Digital Library (Canada)

Rapport de frais de 2017-2018 pour Mary Anne Chambers. Total des frais de déplacement : CAD$17,362.55. Réunion du Conseil des gouverneurs. 19 novembre 2017 au 24 novembre 2017. CAD$2,185.41. Réunions au CRDI 1 novembre 2017 CAD$714.15. Constatation de l'impact de la recherche en Afrique de l'Est.

Mariátegui, Vallejo y la literatura peruana

OpenAIRE

Pérez, Alberto Julián

2007-01-01

Para enriquecer y superar la comprensión eurocéntrica histórica del fenómeno americano es preciso indagar en la reflexión que sobre éste realizan los propios pensadores de América. En este ocasión, nuestra particular elección ha recaído en José Carlos Mariátegui (1895-1930) y su obra Siete ensayos de interpretación de la realidad peruana (1928). Si bien su pensamiento fue poco formal, estuvo enriquecido por intuiciones y observaciones que aún esperan su oportunidad de tener un papel activo en...

[Mari Uusküla. Basic colour terms in Finno-Ugric and Slavonic Languages] / Galina Paramei

Index Scriptorium Estoniae

Paramei, Galina

2010-01-01

Arvustus: Uusküla, Mari. Basic colour terms in Finno-ugric and Slavonic languages: myths and facts. Tartu : Tartu University Press, 2008. Dissertationes linguisticae Universitatis Tartuensis, 1406-5657 ; 9

Marys Lake 69/115-kV transmission line upgrade and substation expansion projects

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-05-01

Western Area Power Administration (Western) and the Platte River Power Authority (Platte River) propose to upgrade portions of the existing electric transmission and substation system that serves the Town of Estes Park, Colorado. The existing transmission lines between the Estes Power Plant Switchyard and the Marys Lake Substation include a 115,000 volt (115-kV) line and 69,000 volt (69-kV) line. Approximately one mile is a double-circuit 115/69-kV line on steel lattice structures, and approximately two miles consists of separate single-circuit 115-kV and a 69-kV lines, constructed on wood H-Frame structures. Both lines were constructed in 1951 by the US Bureau of Reclamation. The existing transmission lines are on rights-of-way (ROW) that vary from 75 feet to 120 feet and are owned by Western. There are 48 landowners adjacent to the existing ROW. All of the houses were built adjacent to the existing ROW after the transmission lines were constructed. Upgrading the existing 69-kV transmission line between the Marys Lake Substation and the Estes Power Plant Switchyard to 115-kV and expanding the Marys Lake Substation was identified as the most effective way in which to improve electric service to Estes Park. The primary purpose and need of the proposed project is to improve the reliability of electric service to the Town of Estes Park. Lack of reliability has been a historical concern, and reliability will always be less than desired until physical improvements are made to the electrical facilities serving Estes Park.

Marys Lake 69/115-kV transmission line upgrade and substation expansion projects

International Nuclear Information System (INIS)

1996-05-01

Western Area Power Administration (Western) and the Platte River Power Authority (Platte River) propose to upgrade portions of the existing electric transmission and substation system that serves the Town of Estes Park, Colorado. The existing transmission lines between the Estes Power Plant Switchyard and the Marys Lake Substation include a 115,000 volt (115-kV) line and 69,000 volt (69-kV) line. Approximately one mile is a double-circuit 115/69-kV line on steel lattice structures, and approximately two miles consists of separate single-circuit 115-kV and a 69-kV lines, constructed on wood H-Frame structures. Both lines were constructed in 1951 by the US Bureau of Reclamation. The existing transmission lines are on rights-of-way (ROW) that vary from 75 feet to 120 feet and are owned by Western. There are 48 landowners adjacent to the existing ROW. All of the houses were built adjacent to the existing ROW after the transmission lines were constructed. Upgrading the existing 69-kV transmission line between the Marys Lake Substation and the Estes Power Plant Switchyard to 115-kV and expanding the Marys Lake Substation was identified as the most effective way in which to improve electric service to Estes Park. The primary purpose and need of the proposed project is to improve the reliability of electric service to the Town of Estes Park. Lack of reliability has been a historical concern, and reliability will always be less than desired until physical improvements are made to the electrical facilities serving Estes Park

Sisemine vabadus määrab identiteedi / Marie-Jo LaFontaine ; interv. Reet Varblane

Index Scriptorium Estoniae

LaFontaine, Marie-Jo

2001-01-01

Intervjuu belgia kunstniku Marie-Jo LaFontaine'iga 25. VII Rakveres. KanaNaha raames eksponeeritud M.-J. LaFontaine'i näitusest "Identiteedi ruum", tema fotodest lastest, kunstiturust Eestis ja Belgias, Belgia pankade kunstikogudest jm.

O marxismo indo-americano de Mariátegui e a polêmica com a III Internacional Comunista.

Directory of Open Access Journals (Sweden)

María Gabriela Guillén

2012-05-01

Full Text Available Partindo da perspectiva marxista indo-americana de José Carlos Mariátegui, o artigo visa a exposição de fatores teóricos e históricos que culminaram na polêmica com a III Internacional Comunista na América Latina. A problemática evidencia a originalidade do pensamento de Mariátegui, cujo eixo central é a interpretação dos fatos históricos, políticos e sociais latino-americanos sob a perspectiva dialética do desenvolvimento desigual e combinado para explicar a dinâmica particular da realidade peruana.

Mari sangari päeva sõnum / Jaak Prozes ; interv. Livia Viitol

Index Scriptorium Estoniae

Prozes, Jaak, 1965-

2006-01-01

Fenno-Ugria Hõimukeskuse juhataja ja Eestimaa Rahvaste Ühenduse juht soome-ugri rahvaste olukorrast Venemaal ja rahvusseltside tegevusest Eestis. Aprilli lõpul tähistasid marid oma rahvuspüha - mari sangari päeva. Pärimuse põhjal langes maride rahvuskangelane Boltu̧ võitluses oma rahva vabaduse eest 26. aprillil 1556

Uus kuum Eesti disain / Silvia Pärmann, Maris Takk

Index Scriptorium Estoniae

Pärmann, Silvia

2015-01-01

Karl Tauli disainitud taburet "Ämblu", Aap Piho puidust ümmargune laud, Marit Ilisoni tekkmantlid kollektsioonist "Longing for Sleep/Magada tahaks", Narma vaibakollektsioon "OPEN 2015/16" (disainerid Monika Järg, Kaidi Ploomipuu), Annike Laigo vaibakollektsioon "XX", Kairi Katmanni vaip "Storytellers", Valhalla Factory kollektsiooni "Daydreamers" ripptool, Raili Keivi betoonist ja portselanist nõudekollektsioon, Tarmo Luisu valgusti "Kassett", Stella Soomlaisi käekotid, Karin Kallase ja Erik Pasti (Stuudio Nahk) disainitud jalatsid, käekotid ja ehted, Kuula + Jylhä jalatsikollektsioon, Mokoko (disainer Mari Maripuu) nahast aksessuaarid

Urbanistid ja keskkonnaeksperdid: iga muudatuse eest Reidi tee projektis oleme pidanud võitlema / Helen Sooväli-Sepping, Kristi Grišakov, Mari Jüssi ; intervjueerinud Mari Peegel ; kommenteerinud Taavi Aas

Index Scriptorium Estoniae

Sooväli-Sepping, Helen, 1974-

2016-01-01

TLÜ keskkonnakorralduse professor ja linnakorralduse õppekava juht Helen Sooväli-Sepping, TTÜ maastikuarhitektuuri õppekava juht ja linnaplaneerija-urbanist Kristi Grišakov ning Stockholmi keskkonnainstituudi Tallinna keskuse liikuvus- ja keskkonnaekspert Mari Jüssi kinnitavad, et Reidi tee projekt ei ole endiselt inimsõbralik

Mary Shelley's Frankenstein: exploring neuroscience, nature, and nurture in the novel and the films.

Science.gov (United States)

Ginn, Sheryl R

2013-01-01

The story of Victor Frankenstein's quest to conquer death produced a legacy that has endured for almost 200 years. Powerful in its condemnation of the scientist's quest to achieve knowledge at any cost, Mary Shelley's Frankenstein is one of the most enduring novels of all time. It has never been out of print and has been translated to both stage and screen many times since its "birth." Numerous novels, short stories, and scripts have drawn upon Shelley's primary theme: the creation of a living organism from the dead, dying, and decaying body parts of human beings. Although Mary does not provide details of the animation process, particularly in her first edition, the process has been explored with a great deal of imagination and originality in the various cinematic portrayals of the story. Equally important as the theme of the scientist's quest for knowledge is the role that a creator plays in the life of its creation. Mary Shelley's novel pondered on how rejection would affect the offspring of such "unnatural" origins. In keeping with the "scientific" basis of the Creature's birth, cinematic portrayals attempted to provide a scientific rationale for the Creature's descent into madness and its evil behavior. From Robert Florey's initial script for the 1931 film directed by James Whale to the more recent films and television series, an abnormal brain is considered to be the cause of the madness and malignity of the Creature. © 2013 Elsevier B.V. All rights reserved.

Golden Girl: Mary Lai Reflects as She Marks Her 50th Anniversary.

Science.gov (United States)

Iwanowski, Jay

1996-01-01

The career and administrative style of Mary M. Lai, who celebrates her 50th year as chief financial officer at Long Island University (New York), are discussed. Her perspectives on change in higher education and in the institution during that time, the administrator's role, current challenges for financial officers, and the college environment as…

Welcoming the Sunlight: A Conversation with Mary Kay Zabel and Robert Zabel

Science.gov (United States)

Teagarden, James; Kaff, Marilyn

2018-01-01

Professors Emeriti Mary Kay and Robert Zabel share their reflections on their long and productive careers working with students and teachers. Their respective careers share much of the same history and complement each other. The Zabels share their advice with those entering the field and the challenges they see for the education of students with…

Mariátegui y la constitución de un socialismo latinoamericano

Directory of Open Access Journals (Sweden)

César Ruiz Sanjuán

2015-01-01

Full Text Available En el presente artículo se analizan los aspectos fundamentales de la concepción socialista de Mariátegui, poniendo de manifiesto sus planteamientos historicistas y voluntaristas frente al economicismo y al determinismo dominantes en la tradición marxista, así como su reformulación del materialismo histórico como método de interpretación no sólo de las sociedades capitalistas desarrolladas, sino también de las sociedades coloniales en las que el capitalismo se encuentra combinado con elementos supervivientes de formaciones sociales anteriores. Se aborda asimismo la comprensión de Mariátegui del partido político como forma de articulación de las relaciones de fuerza de las clases subalternas, que debe emerger del proceso de formación de una voluntad colectiva entre las mismas. Finalmente se examina el modo en que integra en su concepción socialista la cuestión de indigenismo para plantear una forma de transición hacia un socialismo específicamente latinoamericano.

THE DEAD-LIVING-MOTHER: MARIE BONAPARTE'S INTERPRETATION OF EDGAR ALLAN POE'S SHORT STORIES.

Science.gov (United States)

Obaid, Francisco Pizarro

2016-06-01

Princess Marie Bonaparte is an important figure in the history of psychoanalysis, remembered for her crucial role in arranging Freud's escape to safety in London from Nazi Vienna, in 1938. This paper connects us to Bonaparte's work on Poe's short stories. Founded on concepts of Freudian theory and an exhaustive review of the biographical facts, Marie Bonaparte concluded that the works of Edgar Allan Poe drew their most powerful inspirational force from the psychological consequences of the early death of the poet's mother. In Bonaparte's approach, which was powerfully influenced by her recognition of the impact of the death of her own mother when she was born-an understanding she gained in her analysis with Freud-the thesis of the dead-living-mother achieved the status of a paradigmatic key to analyze and understand Poe's literary legacy. This paper explores the background and support of this hypothesis and reviews Bonaparte's interpretation of Poe's most notable short stories, in which extraordinary female figures feature in the narrative.

Manufacturing and Design Engineering Students St. Mary's Hospital, Phoenix Park.

OpenAIRE

Mitchell, Leah

2012-01-01

Poster with details of project to improve ease of movement for Kirton Stirling chairs in St. Mary's Hospital, Phoenix Park, Dublin. Third year students in the B Eng (Honours) Manufacturing and Design Engineering course at Bolton St. completed a project in conjunction with St. Mary‟s Hospital, Phoenix Park. The staff in St Mary‟s were experiencing difficulty in moving the Kirton Stirling chairs (pictured above). These chairs are used to transport elderly patients from one location to another. ...

Hip Subluxation, first clinical manifestation in a boy with illness of Charcot Marie Tooth

International Nuclear Information System (INIS)

Marin Nino, Jorge Enrique; Rosselli Cock, Pablo

2005-01-01

Charcot-Marie-Tooth disease is a motor and sensitive neuropathy characterized by limb atrophy and weakness, cavus feet and in some cases acetabular dysplasia. We present a case of bilateral hip subluxation caused by this disease, which needed surgical correction

Life of Mary Nzimiro (1898-1993): Lessons for the Future of Women ...

African Journals Online (AJOL)

The paper examines the business career and life history of Mary Nzimiro, who rose from petty trader to become a prominent merchant. She started her trading career in the 1920s in Oguta. By 1948 she had become the principal agent of the UAC for the entire Eastern Nigerian Region, and represented the Company in ...

The Gendering of Albert Einstein and Marie Curie in Children's Biographies: Some Tensions

Science.gov (United States)

Wilson, Rachel E.; Jarrard, Amber R.; Tippins, Deborah J.

2009-01-01

Few twentieth century scientists have generated as much interest as Albert Einstein and Marie Currie. Their lives are centrally depicted in numerous children's biographies of famous scientists. Yet their stories reflect interesting paradoxes and tacit sets of unexplored sociocultural assumptions about gender in science education and the larger…

[Heavy metal pollution characteristics and ecological risk analysis for soil in Phyllostachys praecox stands of Lin'an].

Science.gov (United States)

Fang, Xiao-bo; Shi, Han; Liao, Xin-feng; Lou, Zhong; Zhou, Lyu-yan; Yu, Hai-xia; Yao, Lin; Sun, Li-ping

2015-06-01

An investigation was carried out in an attempt to reveal the characteristics of heavy metals contamination in the soils of Phyllostachys praecox forest in Lin' an. Based on the concentrations of Hg, As, Cu, Pb, Zn, Cd, Cr, Ni, Co and Mn in 160 topsoil samples, the pollution status and ecological risks of heavy metals in the soils were assessed by single factor pollution index, Nemerow integrated pollution index and Hankanson potential ecological risk index. The spatial variability of heavy metal concentrations in the soils closely related to the distribution of traffic, industrial and livestock pollution sources. The average concentrations of Hg, As, Cu, Pb, Zn, Cd, Cr, Ni, Co and Mn in the soils were 0.16, 7.41, 34.36, 87.98, 103.98, 0.26, 59.12, 29.56, 11.44 and 350.26 mg · kg(-1), respectively. Pb, Cd, Zn and Cu concentrations were as 2.89, 1.70, 1.12 and 1.12 times as the background values of soil in Zhejiang Province, respectively. But their concentrations were all lower than the threshold values of the National Environmental Quality Standard for Soil (GB 15618-1995). The average single factor pollution index revealed that the level of heavy metal pollution in the soils was in order of Pb>Cd>Cu= Zn>Hg>As>Ni>Co>Cr>Mn. Pb pollution was of moderate level while Cd, Cu and Zn pollutions were slight. There was no soil pollution caused by the other heavy metals. However, the Nemerow integrated pollution index showed that all the 160 soil samples were contaminated by heavy metals to a certain extent. Among total 160 soil samples, slight pollution level, moderate pollution level and heavy pollution level accounted for 55.6%, 29.4% and 15.0%, respectively. The average single factor potential ecological risk index (Er(i)) implied that the potential ecological risk related to Cd reached moderate level, while the others were of slight level. Furthermore, Cd and Hg showed higher potential ecological risk indices which reached up to 256.82 and 187.33 respectively

Marie-Claude Perrin-Chenour. Kate Chopin : ruptures.

Directory of Open Access Journals (Sweden)

Claire Maniez

2006-04-01

Full Text Available Cinquante ans après son «  maître  » Cyrille Arnavon, à qui l’ouvrage est dédié, Marie-Claude Perrin-Chenour poursuit le travail de réhabilitation entrepris par ce dernier, faisant comme lui la part belle au roman phare de Kate Chopin, The Awakening, auquel elle consacre les trois quarts de son texte. Comme l’indique son sous-titre, elle a choisi d’organiser ses quatre chapitres autour de la notion de rupture. Le premier chapitre, «  Les ruptures de l’histoire  », établit un parallèle entre l...

[Mari Laanemets. Zwischen westlicher Moderne und sowjetischer Avantgarde. Inofizielle Kunst in Estland 1969-1978] / Mara Traumane

Index Scriptorium Estoniae

Traumane, Mara

2013-01-01

Arvustus: Laanemets, Mari. Zwischen westlicher Moderne und sowjetischer Avantgarde. Inofizielle Kunst in Estland 1969-1978. (Humboldt-Schriften zur Kunst- und Bildgeschichte, Bd. 14.9 Berlin: Gebr. Mann 2011

Hydric and poro-mechanical behaviour of high performance Andra concrete: effect of microstructure

International Nuclear Information System (INIS)

Zhang, Yao

2014-01-01

This thesis focuses on water retention at high relative humidity (RH) (92-100%) and desiccation shrinkage under moderate temperature (60-80 C) for two high performance concretes CEMI and CEMV (from Andra), in relation with their microstructure.To investigate the origins of the variations in water saturation degree Sw at high RH, both concretes are dried at RH=92, 98 and 100%, from the fully saturated state. For both concretes, sampling affects significantly Sw. For CEMI at 100%RH, sample size also affects Sw, due to surface drying (desorption); at 92 and 98%RH, CEMI is no longer sensitive to surface drying effects; it is sensitive to experimental conditions (RH, T). CEMV is affected by sample size whatever the RH, but not by experimental conditions.From 60 C drying temperature, the relationship between shrinkage and relative mass loss presents four distinct phases. CEMI concrete is dried at 65 C until phase 3 or 4, and then submitted to a coupled poro-mechanical and gas permeability test. For the same sample tested in phase 3 and then 4, a difference in solid skeleton incompressibility modulus Ks is measured, which is significantly lower than the differences in Ks due to sampling.With the Scanning Electron Microscope, the solid phases and morphology of both concretes are quantified. CEM I and CEM V comprise identical phases, even portlandite, yet CEM V concrete has some specific phases, owing to the addition of slag and fly ash. The C-S-H in CEM V have a lower C/S ratio than in CEM I. The (C/S) ratio remains similar when comparing between three different batches. Besides, millimetric pores vary significantly, owing to differences in manufacturing. (author)

MaRIE 1.0: The Matter-Radiation Interactions in Extremes Project, and the Challenge of Dynamic Mesoscale Imaging

Energy Technology Data Exchange (ETDEWEB)

Barnes, Cris William [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Barber, John L. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Kober, Edward Martin [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Lookman, Turab [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Sandberg, Richard L. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Shlachter, Jack S. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Sheffield, Richard L. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

2015-02-23

The Matter-Radiation Interactions in Extremes project will build the experimental facility for the time-dependent control of dynamic material performance. An x-ray free electron laser at up to 42-keV fundamental energy and with photon pulses down to sub-nanosecond spacing, MaRIE 1.0 is designed to meet the challenges of time-dependent mesoscale materials science. Those challenges will be outlined, the techniques of coherent diffractive imaging and dynamic polycrystalline diffraction described, and the resulting requirements defined for a coherent x-ray source. The talk concludes with the role of the MaRIE project and science in the future.

Sister Mary Emil Penet, I.H.M.: Founder of the Sister Formation Conference

Science.gov (United States)

Glisky, Joan

2006-01-01

Mary Emil Penet, I.H.M., (1916-2001) used her talents and charisma to shape the first national organization of American women religious, the Sister Formation Conference (SFC; 1954-1964), facilitating the integrated intellectual, spiritual, psychological, and professional development of vowed women religious. In the decade preceding Vatican II, her…

Charcot-Marie-Tooth disease: frequency of genetic subtypes and guidelines for genetic testing.

LENUS (Irish Health Repository)

Murphy, Sinead M

2012-07-01

Charcot-Marie-Tooth disease (CMT) is a clinically and genetically heterogeneous group of diseases with approximately 45 different causative genes described. The aims of this study were to determine the frequency of different genes in a large cohort of patients with CMT and devise guidelines for genetic testing in practice.

Charcot-Marie-Tooth disease in Denmark

DEFF Research Database (Denmark)

Vaeth, Signe; Vaeth, Michael; Andersen, Henning

2017-01-01

OBJECTIVES: Charcot-Marie-Tooth disease (CMT) is the most common inherited disorder of the peripheral nervous system, yet no studies have compared the mortality in patients with CMT with that of the general population, and prevalence estimates vary considerably. We performed a nationwide register....... The prevalence was estimated by 31 December 2012, and the incidence rate was calculated based on data from 1988 to 2012. We calculated a standardised mortality ratio (SMR) and an absolute excess mortality rate (AER) stratified according to age categories and disease duration. RESULTS: A total of 1534 patients...... a significantly higher SMR in cases below 50 years of age, and in cases with disease duration of more than 10 years. CONCLUSIONS: We found a reduced life expectancy among patients diagnosed with CMT. To our knowledge, this is the first study of CMT to use nationwide register-based data, and the first to report...

From radioactivity to nuclear physics. Marie Curie and Lise Meitner

International Nuclear Information System (INIS)

Sime, R. L.

1996-01-01

In the first part of this century, at a time when few women obtained a higher education and even fewer entered the scientific professions, two exceptional women achieved great prominence in physics: Marie Curie in radioactivity and Lise Meitner in nuclear physics. In this article I outline the scientific work of meitner and Curie, in the context of their backgrounds and career paths that permitted them to overcome many of the obstacles faced by women in science. (author). 20 refs

Petrophysical characterization of Callovo-Oxfordian argillites from the deep borehole Andra EST433 of Montiers-Sur-Saulx (Meuse, France)

International Nuclear Information System (INIS)

Cosenza, P.; Pret, D.; Camerlynck, C.; Fleury, M.; Geraud, Y.; Kremer, T.; Zamora, M.; Landrein, P.; Lebon, P.; Villieras, F.

2012-01-01

Document available in extended abstract form only. Petro-fabric and physico-chemical properties of Meuse/Haute-Marne Callovo-Oxfordian argillite have been extensively studied (e.g. Trouiller, 2006). This research project is aiming at establishing micro-macro models to link microstructural patterns and macroscopic measurements. In this context, data are acquired on the same samples at different scales: (a) microscopic scale (identification of mineralogical phases, mineral mapping, surface area, pore size distribution) and (b) macroscopic scale (hydraulic conductivity, elastic wave velocities, resistivity, thermal conductivity). Ultimately the resulting micro-macro models would be used by Andra to construct 3D representation of the petrophysical properties within the Callovo-Oxfordian formation by the mean of logging data. This project is part of the research programme TAPSS2000 (Present and past transfers in a sedimentary aquifer - aquitard system: a 2000 meter deep drill-hole in the Mesozoic of the Paris Basin). Data acquisition is performed on 9 cores (taken from 558.5 m to 619.5 m deep) of the deep borehole ANDRA EST433 located at Moultiers-sur-Saulx (Meuse, France). These data on the microstructure and the macroscopic physical behaviour of Callovo-Oxfordian show the following features: - The higher the P-and S- wave velocities, the higher the radiologic density measured by X-Ray tomography. These high values of velocities and density are associated with carbonates, the most rigid phase among the rock-bearing minerals. P-wave velocity measurements do not exhibit significant scale effect (i.e., logging vs laboratory). - The most heterogeneous samples (with regard to their values of elastic wave velocities and radiologic density) are located in the upper part of the Callovo-Oxfordian formation, where argillite is more carbonated. On the contrary, the most homogeneous cores that exhibit lower values of elastic wave velocities are located at deeper depths: they are

Mida arvatakse omavalitsustes koolivõrgu optimeerimisest? / Mart Järvik, Maris Liiders, Peeter Aas, Kaarin Veinbergs

Index Scriptorium Estoniae

2012-01-01

Arvamust avaldasid Järvakandi vallavanem, Raplamaa omavalitsuste liidu esimees Mart Järvik, Harju maavalitsuse haridus- ja sotsiaalosakonna juhataja Maris Liiders, Põlva maavalitsuse haridus- ja sotsiaalosakonna juhataja Peeter Aas, Ida-Viru maavalitsuse haridus- ja sotsiaalosakonna juhataja Kaarin Veinbergs

The Story of Heathcliff’s Journey Back to Wuthering Heights de Lin Haire-Sargeant (1992, ou le « deux en un » de la ré-écriture The Story of Heathcliff’s Journey Back to Wuthering Heights by Lin Haire-Sargeant (1992, and a “Two in one” Rewrite

Directory of Open Access Journals (Sweden)

Isabelle Roblin

2009-10-01

Full Text Available Lin Haire-Sargeant’s 1992 novel The Story of Heathcliff’s Journey Back to Wuthering Heights is typical of the interest shown by contemporary American writers in Victorian novels. It could indeed be classified doubly as a “retro-Victorian novel” since it partly re-writes not only Emily Brontë’s most famous novel, Wuthering Heights, as the title points out, but also, somewhat less obviously, Charlotte Brontë’s Jane Eyre. We will study in this article how Lin Haire-Sargeant’s attempt at re-writing highlights the usual aims of the retro-Victorian novel: taking advantage of the blanks left by the source novels to propose to the reader a modern critical approach, while at the same time being as faithful as possible to the writing conventions of the 19th century, and suggesting another point of view on a well-known story, through a postmodern mixing of historical and fictive characters.

Women, Education and the Material Body Politic in Mary Wollstonecraft's "Vindications"

Science.gov (United States)

Bernath, Elizabeth

2016-01-01

This paper discusses Mary Wollstonecraft's "A Vindication of the Rights of Woman: With Strictures on Political and Moral Subjects" and "A Vindication of the Rights of Men" as books of philosophy about rational materialism. Based on an analysis of Lockean thought, as applied to the possibility of women's development of reason,…

Armastus kui vale(m) : Mari Vihmandi ooperi "Armastuse valem" lavastusest Estonias / Ester Võsu ja Kristel Pappel

Index Scriptorium Estoniae

Võsu, Ester, 1975-

2009-01-01

Argentiina kirjaniku Esther Vilari romaani "Nina Glucksteini matemaatika" ainetel valminud Mari Vihmandi ooperist "Armastuse valem", libreto Maimu Berg, lavastaja Liis Kolle, tantsu- ja liikumisseaded Ana Mondini. Esietendus 17. oktoobril 2008 Rahvusooperis Estonia

A MULHER NEGRA E AS RELAÇÕES DE GÊNERO EM MENINO DE ENGENHO DE JOSÉ LINS DO REGO THE BLACK WOMAN AND GENDER RELATIONS IN MENINO DE ENGENHO BY JOSÉ LINS DO REGO

Directory of Open Access Journals (Sweden)

Zélia Monteiro Bora ; Marina Rodrigues de Oliveira

2011-02-01

Full Text Available Os romances do ciclo da cana-de-açúcar, do escritor paraibano José Lins do Rego (1901-1957 e a sua relação com a sociedade e a cultura destacam-se enquanto abordagens ficcionais, através das quais o escritor buscou representar aspectos relevantes para o entendimento das relações de gênero no Nordeste, no começo do século vinte. Tal representação, indiscutivelmente, reflete a perspectiva de um narrador profundamente marcado pelo lugar privilegiado de onde narra e de sua condição existencial, como o neto de um senhor de engenho. Diante desses aspectos, propomo- nos a analisar brevemente as implicações dessa perspectiva sobre a construção simbólica da personagem negra representada no romance. Para tanto, serão utilizados como referenciais críticos, além do citado romance, os estudos de Zagury (1982, Albuquerque Jr. (1999, Azevedo (1996, 2007, Freyre (2006 Chaguri (2009, Schwarz (2008 e Raboni (2010.The so called sugar cane cycle novels by the Parahyban writer Jose Lins do Rego (1901-197 and its relationship with society and culture constitute themselves as fictional approaches through which the writer sought to represent aspects to the understanding of gender relations in the Northeast of Brazil in the early twentieth century. Such representation, undoubtedly reflects the perspective of a narrator deeply marked by the privileged place from which he narrates and his existential condition, as the son of a plantation owner. Given these aspects, we propose to examine briefly the implications of his perspective on the symbolic construction of the black woman characteres represented in the novel. The following

Weak Activity of Haloalkane Dehalogenase LinB with 1,2,3-Trichloropropane Revealed by X-Ray Crystallography and Microcalorimetry▿

OpenAIRE

Monincová, Marta; Prokop, Zbyněk; Vévodová, Jitka; Nagata, Yuji; Damborský, Jiří

2007-01-01

1,2,3-Trichloropropane (TCP) is a highly toxic and recalcitrant compound. Haloalkane dehalogenases are bacterial enzymes that catalyze the cleavage of a carbon-halogen bond in a wide range of organic halogenated compounds. Haloalkane dehalogenase LinB from Sphingobium japonicum UT26 has, for a long time, been considered inactive with TCP, since the reaction cannot be easily detected by conventional analytical methods. Here we demonstrate detection of the weak activity (kcat = 0.005 s−1) of Li...

Mary Wollstonecraft, Margaret Fuller, and Angelina Grimke: Symbolic Convergence and a Nascent Rhetorical Vision.

Science.gov (United States)

Huxman, Susan Schultz

1996-01-01

Invites rhetorical critics to reappraise the way they study discreet social movements and pay isolated tribute to woman's rights figures. Examines how Mary Wollstonecraft, Margaret Fuller, and Angelina Grimke each co-opted the ideational and stylistic rhetorical characteristics of pre-existing social movements (the enlightenment,…

Solvent dependence of organic exciplex fluorescence studied by magnetic effect on reaction yield (M.A.R.Y) spectroscopy

International Nuclear Information System (INIS)

Pal, K.

2011-01-01

This work aims at understanding the various facets of one of the elementary reactions in nature, the electron transfer reaction using MARY (Magnetic effect on Reaction Yield) spectroscopy as a tool. The prime focus of study by the use this technique was the solvent dependence of organic exciplex fluorescence. Apart from that temperature dependent measurements using MARY spectroscopy have been performed to extract the activation energy parameters of electron transfer reaction. The discovery of magnetic field effect on new system was also a part of our study. The study of solvent dependence of organic exciplex fluorescence using MARY spectroscopy was carried out on the system of 9,10-dimethylanthracene (as the fluorophore) and N,N'-dimethylaniline and 4,4'-Bis(dimethylamino) diphenylmethane (as quenchers) in binary solvent mixtures of toluene/dimethylsulfoxide, benzylacetate/dimethylsulfoxide, toluene/propylenecarbonate and propylacetate/butyronitrile. The work focuses on the use of solvent mixtures rather than pure solvents. The solvent mixtures, tailored to simulate different microenvironemets, were employed to find out the effect of preferential solvation on electron transfer reaction. The contrast in the absolute field effect and linewidth values of the MARY spectra obtained in the four system as a function of dielectric constant scan suggest the imperative effect of concentration fluctuation on the electron transfer reaction. Temperature dependent measurements were performed on the system of N,N,N',N'- tetramethylparaphenylendiamin, photo-ionizing in a mixture of toluene/dimethylsulfoxide. However the sluggish response of the system to temperature changes does not really permit us to extract fruitful results. The magnetic field effect on the much studied system of Perylene/ N.N'-dimethylaniline was discovered for the first time. (author) [de

Construction of a Florentine Queen in Paris: the building of Marie de Médicis’s image in the Luxembourg Palace

OpenAIRE

Greer, Alexandra Lyons

2016-01-01

This thesis’ main goal is to answer the question: from where did Peter Paul Rubens’s Life of Marie de Medici Cycle come? Previous literature has focused on the content of the twenty-four canvases of the Medici Cycle and their meanings. However, they have not viewed the Medici Cycle as part of a bigger whole and thus part of a larger agenda that was symbolised through Marie de Medici’s construction and patronage of her own palace in Paris, the Luxembourg Palace. Originally plann...

Sisters in Restaurant Success: A history of The Maramor, Mary Love's Tea Room

OpenAIRE

Jan Whitaker

2017-01-01

In 1920, Mary Love opened The Maramor, a tea room style restaurant in Columbus, Ohio that quickly become recognized as one of the country's fine restaurants. Her career is intertwined with the rise of home economics college programs, helping women gain a new-born confidence that was used to dominate the restaurant and catering industry.

Precipitation and stream water stable isotope data from the Marys River, Oregon in water year 2015.

Data.gov (United States)

U.S. Environmental Protection Agency — Water stable isotope data collected from a range of streams throughout the Marys River basin in water year 2015, and precipitation data collected within the basin at...

An attempt of using soil grain size in calculating the capacity of water unavailable to plants / Próba wykorzystania uziarnienia gleby do obliczania zawartości wody niedostępnej dla roślin

Directory of Open Access Journals (Sweden)

Brogowski Zygmunt

2015-03-01

Full Text Available Celem pracy była próba znalezienia możliwości obliczenia ilości wody niedostępnej dla roślin na podstawie uziarnienia gleb. Frakcje o średnicach <0,02 mm gromadzą od 90,1 do 98,8% całkowitej ilości wody niedostępnej dla roślin, a frakcja iłu koloidalnego (<0,002 mm zatrzymuje od 52,1 do 80,1% tej wody. Gromadzenie wody we frakcjach <0,02 mm znacząco zależy od ich składu mineralogicznego. Obecność we frakcjach illitu, chlorytu oraz kaolinitu powoduje zmniejszenie ilości wody niedostępnej nawet o 40% w stosunku do frakcji zbudowanych ze smektytów, wermikulitów oraz próchnicy. Ze względu na duże zróżnicowanie ilości wody niedostępnej dla roślin w poszczególnych frakcjach granulometrycznych <0,02 mm wynikaj¹ce ze zróżnicowania mineralogicznego tych frakcji nie udało się wyprowadzić współczynników pozwalających na obliczenie ilościowe w glebach wody niedostępnej dla roślin wiązanej w mikroporach <0,2 μm.

Marie Underi luule : mõnest tõlkeprobleemist / Ilse Lehiste ; inglise k. tlk. Ene-Reet Soovik

Index Scriptorium Estoniae

Lehiste, Ilse, 1922-2010

2000-01-01

Orig.: Marie Under's poetry: some problems of translation. Varem ilmunud: Lituanus, 1983, nr. 3. Kaasautor: Rimvydas Shilbajoris. M. Underi luuletuse "Täiskuu" tekst eesti k., tõlge inglise keelde (tlk. I. Lehiste) ja reaalune tõlge inglise keelde, lk. 256-260

Diagnosis of Charcot-Marie-Tooth Disease

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Isabel Banchs

2009-01-01

Full Text Available Charcot-Marie-Tooth (CMT disease or hereditary motor and sensory neuropathy (HMSN is a genetically heterogeneous group of conditions that affect the peripheral nervous system. The disease is characterized by degeneration or abnormal development of peripheral nerves and exhibits a range of patterns of genetic transmission. In the majority of cases, CMT first appears in infancy, and its manifestations include clumsiness of gait, predominantly distal muscular atrophy of the limbs, and deformity of the feet in the form of foot drop. It can be classified according to the pattern of transmission (autosomal dominant, autosomal recessive, or X linked, according to electrophysiological findings (demyelinating or axonal, or according to the causative mutant gene. The classification of CMT is complex and undergoes constant revision as new genes and mutations are discovered. In this paper, we review the most efficient diagnostic algorithms for the molecular diagnosis of CMT, which are based on clinical and electrophysiological data.

Sisters in Restaurant Success: A history of The Maramor, Mary Love's Tea Room

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Jan Whitaker

2017-02-01

Full Text Available In 1920, Mary Love opened The Maramor, a tea room style restaurant in Columbus, Ohio that quickly become recognized as one of the country's fine restaurants. Her career is intertwined with the rise of home economics college programs, helping women gain a new-born confidence that was used to dominate the restaurant and catering industry.

El problema de la identidad nacional en la obra de José Carlos Mariátegui

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Luis Veres

2002-06-01

Full Text Available Au début du XXe siècle, le mouvement « indigéniste » et les idées socialistes se propagent dans tout le Pérou. Nombre de jeunes écrivains, qui voulaient résoudre le problème indien au Pérou et en Amérique Latine, lisent avec beaucoup d’intérêt les ouvrages de Marx, Lénine et Engels. Le marxisme est perçu comme un programme pour expliquer le monde moderne. Cette idéologie influence l’œuvre de l’intellectuel le plus charismatique de cette époque : José Carlos Mariátegui. C’est dans ce contexte qu’il convient de situer son œuvre la plus importante, Siete ensayos de interpretación de la realidad peruana. Dans ce livre, Mariátegui rêve d’un Pérou « intégral », modèle national fondé sur l’unité de toutes les races. Mais, cet ouvrage est parsemé de contradictions qui brisent l’idée d’intégration : des problèmes sociaux et raciaux qui vont à l’encontre de cette cohésion nationale à laquelle Mariátegui aspire, et qui sont le reflet d’une méconnaissance de la réalité.At the beginning of the XXth century, the Indigenist movement and socialist ideology spread out all over Peru. The young writers read Marx, Lenin and Engels’books with a lot of interest, in order to cope with the Indian issue in Peru and South America. Marxism is considered as a valid model to explain the world. This ideology inspires one of the most charismatic intellectuals of this time : Carlos Mariátegui. Siete ensayos de interpretación de la realidad peruana, his most important work has to be replaced in this context. In this book, Mariátegui pleads for an « integral » Peru, a national model based on the unity of all races. But there are some contradictions in this book, which break the idea of integration: social and racial problems which are not consistent with the national cohesion that Mariátegui claims, and which point out some misunderstanding in his analysis of reality.En claro paralelismo con el

The Many Sides of Happy Lim: aka Hom Ah Wing, Lin Jian Fu, Happy Lum, Lin Chien Fu, Hom Yen Chuck, Lam Kin Foo, Lum Kin Foo, Hom, Lim Goon Wing, Lim Gin Foo, Gin Foo Lin, Koon Wing Lim, Henry Chin, Lim Ying Chuck, Lim Ah Wing, et. al.

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Gordon H. Chang

2010-03-01

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Known to the FBI, INS, and IRS as Mr. Ah Wing Hom, he was also Lin Jian Fu, Jian Fu (Tough Guy, or just Fu to the readers of the many poems and short stories he published in Chinese over four decades in the twentieth century. And to still others, primarily English-readers of his writing, he was Happy Lim, an ironic, even tragically bizarre name, as his life was far from pleasant. On New Year's Day 1986, he died alone in a dingy San Francisco Chinatown bachelor hotel suffering from a bacterial infection and a chronic blood disorder that had required the amputation of all his toes the year before. He was seventy-eight years of age and had spent most of his life within blocks of where he died.

The ascent of Mary Somerville in 19th century society

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Strickland, Elisabetta

2016-01-01

This biography traces the life and work of Mary Fairfax Somerville, whose extraordinary mathematical talent only came to light through fortuitous circumstances. Barely taught to read and write as a child, all the science she learned and mastered was self taught. In this delightful narrative the author takes up the challenge of discovering how Somerville came to be one of the most outstanding British women scientists and, furthermore, a popular writer. Particular attention is paid to the gender aspects of Somerville's success in what was, to put it mildly, a predominantly male domain.

Marie Curie and her laboratory: science, industry, instruments and metrology of radioactivity in France, 1896-1914

International Nuclear Information System (INIS)

Boudia, S.

1998-01-01

This thesis treats of the historical aspect of the scientific research on radioactivity in France at the end of the 19. century and the beginning of the 20. century through the works of Marie Curie. (J.S.)

Mary Seacole and claims of evidence-based practice and global influence.

Science.gov (United States)

McDonald, Lynn

2016-01-01

The aim of this paper was to explore the contribution of Mary Seacole to nursing and health care, notably in comparison with that of Florence Nightingale. Much information is available, in print and electronic, that presents Mary Seacole as a nurse, even as a pioneer nurse and leader in public health care. Her own memoir and copious primary sources, show rather than she was a businesswoman, who gave assistance during the Crimean War, mainly to officers. Florence Nightingale's role as the major founder of the nursing profession, a visionary of public health care and key player in advocating 'environmental' health, reflected in her own Notes on Nursing , is ignored or misconstrued. Discussion paper. British newspapers of 19th century and The Times digital archive; Australian and New Zealand newspaper archives, published memoirs, letters and biographies/autobiographies of Crimean War participants were the major sources. Careful examination of primary sources, notably digitized newspaper sources, British, Australian and New Zealand, show that the claims for Seacole's 'global influence' in nursing do not hold, while her use of 'practice-based evidence' might better be called self-assessment. Primary sources, moreover, show substantial evidence of Nightingale's contributions to nursing and health care, in Australia, New Zealand, the USA and many countries and the UK much material shows her influence also on hospital safety and health promotion.

The central nervous system phenotype of X-linked Charcot-Marie-Tooth disease: a transient disorder of children and young adults.

Science.gov (United States)

Al-Mateen, Majeed; Craig, Alexa Kanwit; Chance, Phillip F

2014-03-01

We describe 2 patients with X-linked Charcot-Marie-Tooth disease, type 1 (CMTX1) disease and central nervous system manifestations and review 19 cases from the literature. Our first case had not been previously diagnosed with Charcot-Marie-Tooth disease, and the second case, although known to have Charcot-Marie-Tooth disease, was suspected of having CMTX1 after presentation with central nervous system manifestations. The most common central nervous system manifestations were transient and included dysarthria, ataxia, hemiparesis, and tetraparesis resembling periodic paralysis. Of the 21 patients, 19 presented at 21 years of age or younger, implicating CMTX1 with transient central nervous system manifestations as a disorder that predominantly affects children and adolescents. CMTX1 should be included in the differential diagnosis of patients who present with transient central nervous system phenomena, including stroke-like episodes, tetraparesis suggestive of periodic paralysis, dysarthria, ataxia, or combinations of these deficits. Reversible, bilateral, nonenhancing white matter lesions and restricted diffusion on magnetic resonance imaging are characteristic features of the central nervous system phenotype of CMTX1.

Efeito e modo de ação das bacteriocinas produzidas por Lactococcus lactis subsp. lactis ITAL 383, ATCC 11454 e CNRZ 150 contra Listeria innocua LIN 11 Effect and mode of action of the bacterioncin produced by Lactococcus. lactis subsp. lactis ITAL 383, ATCC 11454 e CNRZ 150 against Listeria innocua LIN 11

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Izildinha MORENO

1999-01-01

Full Text Available O efeito e o modo de ação das bacteriocinas produzidas por L. lactis subsp. lactis ITAL 383 e CNRZ 150 são similares à nisina de L. lactis subsp. lactis ATCC 11454. Estas bacteriocinas apresentaram um modo de ação bactericida, causando a lise de células de L. innocua LIN 11, associada ao decréscimo da absorbância e da viabilidade celular. O efeito letal foi maior para células em fase exponencial comparativamente à fase estacionária de crescimento. A adsorção dessas bacteriocinas às células de L. innocua LIN 11 foi muito rápida e influenciada pelo pH do meio de suspensão; adsorção máxima foi verificada a pH 6,0 e logo após o contato inicial. Perda completa de adsorção ocorreu em pH 2,0.The effect and mode of action of the bacteriocin produced by L. lactis subsp. lactis ITAL 383 and CNRZ 150 are similar to the nisin produced by L. lactis subsp. lactis ATCC 11454. It was clearly bactericidal, and caused lysis of a strain of L. innocua LIN 11 detected by the decrease of absorbance values and the cell viability. Their lethal effect was considerably higher during the logarithmic growth when compared to the stationary phase. Adsorption developed rapidly and was influenced by the pH value of the suspension medium. Maximum adsorption was observed at pH 6,0 and immediately after initial contact and loss at pH 2,0.

Inimkonna hämarus: Marie Under ja saksa ekspressionism / The Twilight of Humanity: Marie Under's Translations of German Expressionist Poetry

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Tiina Ann Kirss

2016-12-01

Full Text Available Teesid: 1920. aastal avaldas Marie Under eestikeelse tõlkevalimiku saksa uuemast lüürikast, milles suurim osakaal on ekspressionistlikel luuletajatel. Koos selle vaatlusega käsitleb artikkel Underi hinnangut ekspressionismile kui kultuurinähtusele ning ekspressionistlikke siirdeid kahes Underi luulekogus, „Verivalla“ ja „Pärisosa“. Luule tõlkimine võib toita luuletaja loomingulisi allikaid, kuid huvitavad on ka need juhtumid, kui luuletaja neist läbitöötatud vormidest lõpuks loobub.   In 1920 Estonian poet Marie Under published an anthology of translations from recent German poetry, the largest number of which were expressionists. Most of the poems were chosen from Kurt Pinthus’ anthology Menschheitsdämmerung: Symphonie jüngster Dichtung, published in 1920, a carefully composed summa of German expressionist poetry. Under’s first examples of expressionist translations, published in the album of the Siuru group of poets in 1919 met with arch and scathing criticism, particularly on the level of style: ostensibly she had “beautified” expressionist rhetoric. She was not deterred, but persisted, and alongside the volume of translations published a short critical article on expressionism and its ethical dimension in the newspaper Tallinna Teataja, where she outlined Kurt Pinthus’ justifications for the composition and structuring of his edited anthology. This paper explores Under’s part in the cultural transfer of German expressionist lyric poetry into Estonian: her selections of authors and individual poems, the periodization of the movement through the table of contents, the emphases and omissions of the resultant whole. Secondly, and more importantly the paper investigates the impact of expressionist topics and rhetoric on Under’s two next volumes of poetry, Verivalla (Land of Blood, 1919–1920 and Pärisosa (Portion, 1920–1922. The main focus of this analysis is on Under’s lexical experiments and stylistic

The war of thrones: Elisabeth and Mary Stuart

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José Renato Ferraz da Silveira

2013-11-01

Full Text Available By means of literature research, this article seeks to analyze the historical time of Queen Elisabeth regarding, in particular, the clash with the Scottish queen Mary Stuart. We selected - as cutouts for analysis - conflicts, paradoxes and tensions that underlie the search for legality and legitimacy. In the eternal struggle for power, the characters are faced with political life and death, the rise and decay, the glory and failure, which are inevitable and constitutive stages of the game of thrones. In this study, under a realistic bias, we discuss the triad - conquest maintenance and fall from power - about the shocking and devastating meaning of politic as tragedy in the pursuit of order and harmony in the face of chaos and instability is always present.

Mary Dorcey: The Poet’s Gaze and Scalpel

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Maria Micaela Coppola

2015-07-01

Full Text Available Precision, vividness and colour characterise Mary Dorcey’s representations of individual and yet universal human experiences, such as love, loss, or grief. These are used like a surgeon’s scalpel: to frame, look inside, and closely observe sections of the individual’s body, and life. As we can see from the selection of poetic and prose texts presented here (alongside their translations into Italian, Dorcey cuts the skin of common definitions of private places and feelings (home, love, and grief. She looks at them from uncommon perspectives, bears witness to them, and gains insight from them. These and other issues are discussed in the interview, which is a revised version of a conversation that took place in Bologna (Italy in November 2014.

Making Socialists: Mary Bridges Adams and the Fight for Knowledge and Power, 1855-1939

Science.gov (United States)

Weiler, Kathleen

2012-01-01

This article presents a review of "Making socialists: Mary Bridges Adams and the fight for knowledge and power, 1855-1939," by Jane Martin. Jane Martin has explored the history of late-nineteenth-century and early-twentieth century-British women educational activists in numerous publications over the past two decades. Her first book,…

Decree no. 2003-30 of the 10 january 2003 authorizing the national agency for the radioactive wastes management (ANDRA) to modify, for the survey step, the radioactive wastes storage center of the Manche (base nuclear installation no. 66), located on the Digulleville municipality territory (Manche)

International Nuclear Information System (INIS)

2003-01-01

This document, took out from the Official Journal, is the law text relative to the decree no. 2003-30 of the 10 january 2003 authorizing the national agency for the radioactive wastes management (ANDRA) to modify, for the survey step, the radioactive wastes storage center of the Manche (base nuclear installation no. 66), located on the Digulleville municipality territory (Manche). (A.L.B.)

An experimental study of the thermal conductivity: application of EST 205 borehole of Meuse/Haute Marne site (ANDRA); Etude experimentale de la conductivite thermique: application au forage EST 205 du site de Meuse/Haute Marne (ANDRA)

Energy Technology Data Exchange (ETDEWEB)

Jorand, R

2006-10-15

The determination of the thermal properties of clayey rocks is fundamental for predicting the behaviour a radioactive waste geological repository, and geothermal and oil reservoirs. The main objectives of this thesis work were to 1) better understand the effects of the parameters controlling the thermal conductivity, 2) study to which extent the laboratory measurements can be extrapolated to the field, and 3) find relationships between the thermal conductivity and other quantities easier to measure on the field, e.g. the P- and S- wave velocities. The study was conducted on 24 cores of marls carbonates and argillites coming from the EST205 borehole of the M/HM site (ANDRA). After a complete characterisation of the samples, their thermal conductivities were measured using a stationary method. The borehole was drilled with a special oil-based mud to avoid damaging the argillites, and many logs were available. Hence, it is ideal to study the properties of clayey rocks and compare them with field data. The results show the major effect of the microstructure (mainly the particles orientation), which causes the important anisotropy of the thermal conductivity in the marls and argillites. For all lithologies, linear relationships between the conductivity and the P- and S- wave velocities were obtained. The application of this experimental law to the sonic log helped building a synthetic log of thermal conductivity. Finally, we developed a heat probe, which allows measurements in function of temperature and saturation. We showed with this method that the thermal conductivity increases quasi-linearly with the saturation in a sandstone and a carbonate samples. (author)

Marie Underist, P. Mustapääst ja 1920. aastate ballaadidest. On Marie Under, P. Mustapää, and Ballads of the 1920s

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Satu Grünthal

2012-04-01

Full Text Available The purpose of this article is to discuss the poetic relations between two neighbouring countries with a particular emphasis on the ballad. For both Estonian and Finnish poetry, the 1920s were a productive and interesting period for the writing of ballads. I will focus my inquiry on two poets, Marie Under and P. Mustapää. Closer analysis will be carried out of one motif, the self-sacrificing woman, which is found in the ballads of both poets, particularly in view of the importance of these ballad themes in the context of the art and social life of the 1920s. From the perspective of comparing Finnish and Estonian literature, it is interesting to examine common features and reciprocal influences in their ballads. For Finnish poet Martti Haavio, whose pen name was P. Mustapää, Estonian poetry of the 1920s was an important source of inspiration and models, a fact that he emphasized especially in his memoirs, and which was also expressed mainly in his later poetry. Marie Under held an important place among the Estonian poets who inspired P. Mustapää; in the article this is demonstrated through a thorough analysis of P. Mustapää’s poem „Under the Laurel Trees” („Varjossa laakerien”. The poem moves on two levels. On the one hand, its content is the poet`s childhood memory, on the other – as is so often characteristic of P. Mustapää, the poem treats metapoetically of the process of how poetry and art are born, and of the wonder of creation. Both Marie Under and P. Mustapää wrote many ballads, and in addition, P. Mustapää used ballad motifs in many of his other poems. In the article, the motif of the self-sacrificing woman is discussed with respect to the works of both poets. Closer examination is given to P. Mustapää’s poem „The White Lady of Haapsalu”, a poem that contains ballad material, and to Under’s ballad „The Birth of Naissaar”, with additional comments on her ballads „False Foot”(„Ebajalg” and �

Feeling vs vorm. White label : Under Marie. Kuula / DJ Pickney Tiger

Index Scriptorium Estoniae

DJ Pickney Tiger, pseud., 1970-

2007-01-01

Rockansambli Chungin and the Strap-On-Faggots ja soome punkbändi Rejects kontserdist Tallinnas Reggae Baaris. Heliplaadist: Under Marie "1. What What? 2. What What?". Heliplaatidest: Zahir "Green means go", Ry Cooder "My name is Buddy", Ladysmith Black Mambazo "Warner Bros. Collection", Macy Gray "Big", Nneka "Victim of Truth", "Grinderman", Stooges "The Weirdness", "The Good, The Bad and the Queen", Marco Di Marco "In New York, My Poetry", Kaiser Chiefs "Yours Truly, Angry Mob", Mika "Life in cartoon motion"

Marie Curie, les femmes et la science, d'hier à aujourd'hui

CERN Multimedia

CERN. Geneva; Mariotti, Chiara; Vicinanza, Domenico

2017-01-01

Marie Curie, les femmes et la science, d'hier à aujourd'hui Conférence par Hélène Langevin-Joliot Avec la participation de l'Echo du Reculet de Thoiry. L'enregistrement et la liste d'attente sont déjà complets... Mais il n'est pas rare que des personnes réservent et ne viennent pas. Nous réassignerons les places libérées selon la règle "premier arrivé, premier inscrit". Au vu de la forte demande, la conférence sera également disponible en vidéoconférence : lien d'accès "webcast" disponible en bas de cette page. Hélène Langevin-Joliot, directrice de recherche émérite en physique nucléaire fondamentale au CNRS à Orsay, est aussi la fille de Frédéric et Irène Joliot-Curie (prix Nobel de chimie en 1935) et la petite-fille de Pierre Curie (prix Nobel de physique en 1903) et de Marie Curie (prix Nobel de physique en 1903 et prix Nobel de chimie en 1911). Hélène Langevin-Joliot nous parlera de sa vie scientifique, de l’histoire extraordinai...

Footprints, Imprints: Seeing Environmentalist and Buddhist Marie Byles as an Eastern Australian

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Allison Jane Cadzow

2007-01-01

Full Text Available This paper looks at the Australian author, traveller, conservationist and Buddhist Marie Byles (1900-1979 as “eastern” and Australian at once. It investigates the influence of Buddhist spirituality and travel on her approach to the environment and explores some possibilities arising from looking at her work as part of a broader transnational humanitarian and intellectual identification, moving beyond ethnicity based boundaries. Thinking about eastern Australian identities can encourage consideration of Australia in Asia, Australia as Asian, connections across seas, and links and differences within Australia. The paper explores Marie Byles as an eastern Australian by considering her travel in Sydney and the region (in Australia, China, Vietnam, India and Burma from the 1930s to the 1960s, the design and use of her home as a hub for early Buddhist meetings, her publication of texts discussing Eastern philosophy, and her environmental activism. Throughout the discussion Byles’s understanding of power relations, derived from an entwining of feminist and socialist ideas, a pacifist and Buddhist/spiritualist revaluation of environments emerges. From these influences she provided challenges to her fellow walkers, environmentalists, and society at large to rethink relationships with nature and each other, insights that have yet to be adequately explored and recognised.

Marie Žlábková - Höfnerová jako učitelka a osvětářka

OpenAIRE

MÜGLOVÁ, Marcela

2015-01-01

Diploma Thesis is focused on personality Marie Žlábkové-Höfnerové, Women who spread awareness and thoughts of women independence. First part of thesis is going to map path of world and Czech feminism, it´s Czech origins and changes in gender stereotypes, which it brought.Second part of thesis is focused on celibacy of teachers, as an historic phenomena, with so far unknown regional aspects. Main part of thesis is focused on less known character of Marie Žlábkové-Höfnerové, who as a teacher ha...

The wild heart of a wild land. Tra le Alpi albanesi sulle orme di Mary Edith Durham

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M. Genesin

2012-08-01

Full Text Available ENIn 2007 we decided to follow the same route through northern Albania which was covered almost 100 years ago by the victorian traveller Mary Edith Durham, author of the books High Albania and Some Tribal Origins, Laws and Customs of the Balkans. The journey described in High Albania was the culmination of seven years of regular Balkan travels during which she was rewarded with insights into north Albanian life denied to all previous travellers. Unlike her other expeditions in the Balkans, her journey in northern Albania was an existential experience which deeply affected Durham’s perception of the tribespeople’s world and marked a turning point in her life. In the second part of the article some ethnographical aspects which were pointed out by Durham and are still alive in those regions are dealt with. Keywords: Balkan Studies; Cultural Studies; Ethnography; Mary Edith Durham; Albania  ITNel 2007 abbiamo deciso di organizzare una spedizione a carattere linguistico e etnogrfico nell’Albania settentrionale sulle orme dell’itinerario percorso quasi 100 anni prima dalla viaggiatrice vittoriana Mary Edith Durham, autrice dei volumi High Albania e Some Tribal Origins, Laws and Customs of the Balkans. L’itinerario descritto in High Albania coronò setti lunghi anni di esplorazioni balcaniche nel corso delle quali l’autrice riuscì a penetrare nella vita della popolazione locale, un importante esperienza che era invece mancata a tutti i precedenti viaggiatori. A differenza dagli altri viaggi precedenti nei balcani, quello nell’Albania settentrionale costituì un esperienza esistenziale che segnò profondamente la percezione della Durham del mondo delle alpi albanesi e rappresentò una svolta nella sua vita. Nella seconda parte dell’articolo sono illustrati alcuni fenomeni di carattere etnografico che furono rilevati dalla Durham e che, con nostra grande sorpresa, abbiamo potuto riscontrare sul campo nel corso della spedizione. �

Evidence of cation vacancy induced room temperature ferromagnetism in Li-N codoped ZnO thin films

Science.gov (United States)

Zhang, B. Y.; Yao, B.; Li, Y. F.; Liu, A. M.; Zhang, Z. Z.; Li, B. H.; Xing, G. Z.; Wu, T.; Qin, X. B.; Zhao, D. X.; Shan, C. X.; Shen, D. Z.

2011-10-01

Room temperature ferromagnetism (RTFM) was observed in Li-N codoped ZnO thin films [ZnO:(Li, N)] fabricated by plasma-assisted molecular beam epitaxy, and p-type ZnO:(Li, N) shows the strongest RTFM. Positron annihilation spectroscopy and low temperature photoluminescence measurements indicate that the RTFM in ZnO:(Li, N) is attributed to the defect complex related to VZn, such as VZn and Lii-NO-VZn complex, well supported by first-principles calculations. The incorporation of NO can stabilize and enhance the RTFM of ZnO:(Li, N) by combining with Lii to form Lii-NO complex, which restrains the compensation of Lii for VZn and makes the ZnO:(Li, N) conduct in p-type.

99mTc-DMSA Uptake in a Sister Mary Joseph's Nodule From Ovarian Cancer.

Science.gov (United States)

Naddaf, Sleiman; Azzumeea, Fahad; Fahad Alzayed, Mohammed

2016-12-01

A 50-year-old woman with ovarian cancer underwent Tc-DMSA scan to evaluate the functional status of the right hydronephrotic kidney. The images incidentally revealed a well-defined focus of mild radiotracer uptake at the midanterior abdominal wall, which correlated with a metastatic Sister Mary Joseph's nodule seen on CT performed a week earlier.

Magic Women on the Margins: Ec-Centric Models in Mary Poppins and Ms Wiz

Science.gov (United States)

Valverde, Cristina Perez

2009-01-01

This paper offers a comparative analysis of two characters belonging to the tradition of empowered "spinster" in children's fiction, namely Mary Poppins and Ms Wiz, from the perspective of gender politics and child/adult interactions. A distinction is made between the figure portrayed in P. L. Travers' texts and the Disney film starring Julie…

Response to Marie Paz Morales' ``Influence of culture and language sensitive physics on science attitude achievement''

Science.gov (United States)

Cole, Mikel Walker

2015-12-01

This response to Marie Paz Morales' "Influence of culture and language sensitive physics on science attitude achievement" explores the ideas of culturally responsive pedagogy and critical literacy to examine some implications for culturally responsive science instruction implicit in the original manuscript.

Mirzam C. Pérez, The Comedia of Virginity: Mary and the Politics of Seventeenth-Century Spanish Theater

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Natalia Fernández

2016-01-01

Full Text Available Reseña de Mirzam C. Pérez, The Comedia of Virginity: Mary and the Politics of Seventeenth-Century Spanish Theater, Waco (Texas, Baylor University Press, 2012, 173 pp. ISBN: 9781602586451.

Book presentation followed by discussion: "HEP - still an unfeminine profession?" with Mary K Gaillard

CERN Multimedia

CERN. Geneva; Gaillard, Mary K

2016-01-01

In 1981 Mary K Gaillard became the first woman on the physics faculty at the University of California at Berkeley. Her career as a theoretical physicist spanned the period from the inception — in the late 1960s and early 1970s — of what is now known as the Standard Model of particle physics and its experimental confirmation, culminating with the discovery of the Higgs particle in 2012. Her book A Singularly Unfeminine Profession recounts Gaillard's experiences as a woman in a very male-dominated field, while tracing the development of the Standard Model as she witnessed it and participated in it. Following the book presentation, Prof. Valerie Gibson from the University of Cambridge will comment on her own journey and how it is to be a woman in the world of physics today during a discussion round with P.E.Mary K Gaillard and the audience. The discussion round will be moderated by Geneviève Guinot, the CERN Diversity Programme Leader. Coffee will be served at 3:30pm. Th...

Grenzgängerin in der Frauenbewegung. Eine biographische Annäherung an Marie Stritt

Directory of Open Access Journals (Sweden)

Katja Weller

2005-11-01

Full Text Available Im politischen Wirken der Frauenrechtlerin Marie Stritt (1855–1928 liefen unterschiedliche Traditionslinien der organisierten bürgerlichen Frauenbewegung zusammen. Stritt stand sowohl dem kleinen Kreis kompromissloser Stimmrechtsaktivistinnen und Sexualreformerinnen nahe, der damals wie heute häufig als ‚radikal‘ bezeichnet wird. Beeinflusst war sie aber auch von der als ‚gemäßigt‘ etikettierten Majorität im Bund Deutscher Frauenvereine (BDF. Sie lehnte das Denken in vereinfachenden, polarisierenden Kategorien ab und bemühte sich vor allem in ihrer Funktion als Vorsitzende des BDF von 1899 bis 1910 um Vermittlung zwischen den konkurrierenden Frauenkreisen. Zu einer Zeit, in der sich die Frauenvereinsbewegung immer stärker ausdifferenzierte und politisierte, agierte Stritt an der Schnittstelle der verschiedenen treibenden Kräfte. Dass Marie Stritts Vita bislang nur oberflächlich untersucht wurde, erstaunt angesichts dieser herausgehobenen Bedeutung. Elke Schüllers quellengesättigte „biographische Annäherung“ (S. 89 füllt diese Forschungslücke jetzt dankenswerter Weise und bietet dabei neue Erkenntnisse über die Geschichte des BDF.

Mary Richmond in the perspective of Social Work in Spain

Directory of Open Access Journals (Sweden)

Lourdes Barriga Muñoz

2011-09-01

Full Text Available Our personal experience has shown that, although nobody questions that Mary Richmond received a Ph.D. Honoris Causa «for having set the scientific bases of a new profession», (ours such scientific bases still remain unknown, due to never having been taught as such and due to the lack of theoretical production aimed at refuting, developing or, at least, transmitting them without tergiversation.In this article, we try to present just some quick brush strokes of those scientific bases, mainly because we are conscious of the fact that, in our country, our profession is being rapidly devaluated from many standpoints, identifying it only with resource management and social control and, in the current situation in which social theory finds itself, appearing to have no possibility of modifying that trend.It would be easy to state that the solution would be simply to recover Mary Richmond’s works, but it is not as simple as that since conceptions, ideology, perspectives and finally, the ways of conceiving the present social reality are opposed to those underlying those works. So, we believe that we need an unencumbered view, independent of social sciences, to rediscover our origins, in which we really were a profession, a social discipline with its own know-how and its own way of working, and not just an office to receive those who request an appointment. On the contrary, we aim to influence other sciences, enrich them and demonstrate that social work is a profession necessary to humanity.

Kuis saada läbi Siirita? / Mari-Ann Kelam, Erika Salumäe, Sirje Endre

Index Scriptorium Estoniae

Kelam, Mari-Ann, 1946-

2001-01-01

Riigikogu uude juhatusse ei kuulu ühtegi naist : Keskerakond valis Siiri Oviiri asemele Riigikogu aseesimehe kohale Peeter Kreitzbergi. Naiste osalemisvõimalust poliitikas kommenteerivad Riigikogu naisliikmed Mari-Ann Kelam, Erika Salumäe, Sirje Endre, Jaana Padrik, Viive Rosenberg, Mai Treial, Ivi Eenmaa, Liis Klaar, Liia Hänni, Laine Tarvis

Insener Heinrich Laul ja Eesti XX sajandi ehituskultuur / Maris Suits, Carl-Dag Lige

Index Scriptorium Estoniae

Suits, Maris

2010-01-01

Näitus "Heinrich Laul 100" Tallinna Tehnikaülikoolis 10. sept.-4. okt. 2010. Näituse koostajad: Maris Suits (Eesti Kunstiakadeemia), Carl-Dag Lige (Helsingi Ülikool), Milvi Vahtra (TTÜ), näituse korraldajad: Signe Jantson ja Karl Õiger (TTÜ). Ehitusinsenerist ja -teadlasest Heinrich Laulust, tema tegevusest, seostest August Komendandiga. Koorikute koolkonnast ja teaduspõhisest ehituspraktikast. Tallinna laululavast. Seminarist ja H. Laulu artiklikogumikust

Joint ANDRA/Nirex/SKB zone of excavation disturbance experiment (ZEDEX) at the Aspo hard rock laboratory

International Nuclear Information System (INIS)

Hooper, A.J.; Olsson, O.

1995-01-01

The excavation of access shafts and tunnels and of the disposal areas of a waste repository will cause a disturbance in the surrounding rock mass with possible alterations to rock mass stability and hydraulic properties. For a number of disposal concepts this disturbance may be important for the operational and/or post-closure safety of the repository. Furthermore the disturbance may extend over time as a consequence of processes such as stress relaxation. The sponsors of ZEDEX, namely ANDRA, Nirex and SKB, are interested in developing the ability to produce reliable models of the disturbed zone that will develop around large cross-section excavations in fractured hard rock masses that are initially water saturated. Various models have been developed to calculate the important characteristics of the disturbed zone in such rock masses as a function of parameters related to the rock mass quality and the geometric description of the excavation. ZEDEX was initiated in the Aspo Hard Rock Laboratory in April 1994 with drilling and instrumentation of boreholes running alongside the planned extension of the spiral access ramp and a planned parallel experimental tunnel. ZEDEX has been designed to generate information for alternative methods of excavation. The extension to the spiral ramp is to be made by tunnel boring whereas the parallel experimental tunnel will be excavated in part by ''normal'' basting and in part by smooth blasting. The objective is to build confidence in the modelling of the disturbed zone to support the selection of excavation methods for repository construction. (authors). 3 figs

Difficulties in teaching electromagnetism: an eight year experience at Pierre and Marie Curie University

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H. Roussel

2012-07-01

Full Text Available We will begin by outlining the details of how electromagnetics are taught in the  electrical engineering program offered at Pierre and Marie Curie University (a French example from the undergraduate to the Masters degree levels.  We will also discuss how our methods are and should be adapted to teach waves propagation without discouraging students.

Convention of August the 3-rd 2010 between the French State and the ANDRA about the future investment program (action 'research in waste processing and storage')

International Nuclear Information System (INIS)

2010-01-01

Published in the 'Journal Officiel' as a contract between the French State and the ANDRA (the French national agency for the management of radioactive wastes), this text first defines the financed action, describes the selection of beneficiaries, describes the various financial and accounting arrangements, defines the foreseen organisation and means within the operator, defines the assessment process, the implementation follow-up. The concerned action deals with the setting up of valorization or recycling activities for low radioactive metallic wastes produced by the dismantling of nuclear installations, and with the development of innovating processes and technologies for the processing of chemically reactive radioactive wastes in order to make their storage easier. Others objectives are to decrease the waste volume, to store wastes from small producers, to obtain the most inert as possible physical-chemical state, and to facilitate the storage of some particular wastes

New numerical modelling of the mechanical long-term behaviour of the GMR gallery in ANDRA's Underground Research Laboratory

International Nuclear Information System (INIS)

Blanco Martin, L.; Hadj-Hassen, F.; Tijani, M.; Armand, G.

2011-01-01

This paper deals with a new macroscopic numerical modelling of the mechanical long-term behaviour of ANDRA's Underground Research Laboratory. The study focuses on the GMR gallery, oriented along the minor horizontal principal stress and located at the main level 490 m deep. The simulations are made using the finite element method (FEM).Convergence measurements in this gallery exhibit an important dis-symmetry between the vertical and horizontal directions, as well as a significant time effect in the vertical trend. In attempts to both understand the phenomena that lie beneath such dis-symmetry and reproduce the experimental data, a modification to Lemaitre's creep law has been proposed. The new viscoplastic law takes into account the following aspects: rock transverse isotropy, creep behaviour and rock expansion. The excavation history of the GMR gallery has also been considered in the numerical modelling. The numerical results are very satisfactory for the GMR drift. However, the mechanisms of anisotropic shear and expansion on which the new law is based do not lead to an accurate reproduction of the data measured in the galleries oriented in the perpendicular direction. Therefore, a thorough insight into the mechanical behaviour of the rock mass and into the proposed new law is needed before the latter can be applied to the Callovo-Oxfordian layer. (authors)

The lives of Mary Foote: painter and Jungian.

Science.gov (United States)

Trousdell, Richard

2016-11-01

Mary Foote (1872-1968) was a successful early twentieth century American artist who suddenly closed her New York studio in 1926 to go to Zurich to study with Jung. There she joined his 'Interpretation of Visions' seminars (1930-1934), which she recorded and edited. This work won Jung's praise and his friendship, but all too often Foote was seen merely as a secretary or background figure. Deirdre Bair's biography of Jung suggested that Foote's life and work deserved fuller study, if only to rebalance our view of Jung's early women followers. This paper takes up that work to ask how Foote's early life and career led to her important work in preserving and describing Jung's earliest attempts to apply his theories to clinical practice. © 2016, The Society of Analytical Psychology.

A composer’s inner biography a sketch for the study of influences in Ljubica Marić’s oeuvre

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Melita Milin

2004-01-01

Full Text Available Attempting to investigate works of music through frank examination of possible influences is a delicate thing, sometimes maybe dangerous - as has been suggested by Jonathan Cross in his book, The Stravinsky Legacy. While the originality of a composer may appear to be threatened with such types of critique, for musicologists it is important to draw upon a deeper appreciation for how a composer searched for his/her own creative voice. The music of Ljubica Marić (1909-2003, one of the most important Serbian composers of the 20th century, has been chosen to demonstrate how composers need different influences during different phases of their maturation and how they deeply integrate them in order to create an individual utterance. Ljubica Marić first studied composition with Josip Slavenski at the Belgrade Music School (1925-29, and continued her studies with Josef Suk at the Master School of the Prague Conservatory (1929-32 where she obtained her diploma. Finally, she took Alois Hába’s course in quarter-tone music at the same institution from 1936 to 1937. The works she composed during the 1930’s were characterized by a radical will to break ties with traditional, mainly romantic music, so she chose to be influenced by the free atonal pre-dodecaphonic works of Arnold Schoenberg. Following World War II, she introduced some changes of expression that were more in keeping with links from the past. Her music became tonally stabilized, and thematic-motivational developments were rediscovered, resulting in an expression that became milder. But the changes need not necessarily be linked exclusively to the post-war climate of socialist realism. Rather, the previous style may have met up with some type of impasse - the sort that confounds or ultimately transforms an artist. For Ljubica Marić, however, it appears she was never truly satisfied with her first post-war works (1945-1950. What is certain is that she composed nothing during the several years

Leaching and solvent extraction at Mary Kathleen Uranium Ltd

International Nuclear Information System (INIS)

Richmond, G.D.

1978-01-01

Mary Kathleen Uranium Ltd. recommenced operations in early 1976 following a twelve year period of care and maintenance. Several sections of the plant were modified or completely changed for the second operation. The most important change was the replacement of ion exchange with solvent extraction as the means of purifying and upgrading uranium rich solutions. Most of the problems experienced in the solvent extraction system originate from the leach liquor which has a strong tendency to form stable emulsions. This has been countered by some careful control of leaching conditions and by closer observation of operations in the solvent extraction area. Most problems have now been resolved and plant recoveries are quite satisfactory

Flood-inundation maps for the St. Marys River at Fort Wayne, Indiana

Science.gov (United States)

Menke, Chad D.; Kim, Moon H.; Fowler, Kathleen K.

2012-01-01

Digital flood-inundation maps for a 9-mile reach of the St. Marys River that extends from South Anthony Boulevard to Main Street at Fort Wayne, Indiana, were created by the U.S. Geological Survey (USGS) in cooperation with the City of Fort Wayne. The inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site, depict estimates of the areal extent of flooding corresponding to selected water levels (stages) at the USGS streamgage 04182000 St. Marys River near Fort Wayne, Ind. Current conditions at the USGS streamgages in Indiana may be obtained from the National Water Information System: Web Interface. In addition, the information has been provided to the National Weather Service (NWS) for incorporation into their Advanced Hydrologic Prediction Service (AHPS) flood warning system. The NWS forecasts flood hydrographs at many places that are often collocated at USGS streamgages. That forecasted peak-stage information, also available on the Internet, may be used in conjunction with the maps developed in this study to show predicted areas of flood inundation. In this study, water-surface profiles were simulated for the stream reach by means of a hydraulic one-dimensional step-backwater model. The model was calibrated using the most current stage-discharge relation at the USGS streamgage 04182000 St. Marys River near Fort Wayne, Ind. The hydraulic model was then used to simulate 11 water-surface profiles for flood stages at 1-ft intervals referenced to the streamgage datum and ranging from bankfull to approximately the highest recorded water level at the streamgage. The simulated water-surface profiles were then combined with a geographic information system digital elevation model (derived from Light Detection and Ranging (LiDAR) data) in order to delineate the area flooded at each water level. A flood inundation map was generated for each water-surface profile stage (11 maps in all) so that for any given flood stage users will be

Mary Carroll Craig Bradford: Providing Opportunities to Colorado's Women and Children through Suffrage and Education

Science.gov (United States)

Caldwell, Heather Kleinpeter

2009-01-01

This dissertation is a historical biography on the life, suffrage and educational contributions of Mary Carroll Craig Bradford, a wife, mother, suffragist, teacher and educational administrator in the state of Colorado. The purpose of this dissertation was to find out exactly what Bradford's contributions were to her state. The initial observation…

Response to Marie Paz Morales' "Influence of Culture and Language Sensitive Physics on Science Attitude Achievement"

Science.gov (United States)

Cole, Mikel Walker

2015-01-01

This response to Marie Paz Morales' "Influence of culture and language sensitive physics on science attitude achievement" explores the ideas of culturally responsive pedagogy and critical literacy to examine some implications for culturally responsive science instruction implicit in the original manuscript. [For "Influence of…

Manifest Destiny's Child: Mary Hazelton Blanchard Wade and the Literature of American Empire

Science.gov (United States)

Tunc, Tanfer Emin

2017-01-01

This article discusses how, following in the footsteps of United States imperial children's writers Jacob Abbott and Edward Stratemeyer, Mary Hazelton Blanchard Wade (1860-1936), the original author of the "Our Little Cousins" series (1901-1905), contributed to the American culture of empire. Wade was one of the most prolific and popular…

Municipio Mariño Estado Nueva Esparta

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María Medina

2008-01-01

Full Text Available Se caracteriza la gastronomía típica margariteña como atractivo turístico del Municipio Mariño, sus componentes: restaurantes, autores, platos y promoción. Para formular recomendaciones que permitan su aprovechamiento. Los fundamentos teóricos se basan en el área turismo y gastronomía, y su importancia para la actividad. La metodología es descriptiva y su diseño es de campo. Como conclusión se tiene que la situación actual de la gastronomía típica margariteña como atractivo turístico del municipio se caracteriza por la falta de información y promoción, la cual no se está aprovechando como atractivo turístico debido a la falta de conocimiento sobre la gastronomía típica margariteña y donde además en los restaurantes del municipio se están modificando las recetas originales.

Using water quality to assess ecological condition in the St. Marys River and Huron-Erie Corridor

Science.gov (United States)

The St. Marys River and Huron-Erie-Corridor were assessed by EPA for the first time in 2014-2016 as part of the National Coastal Condition Assessment (NCCA). NCCA uses a probabilistic survey design to allow unbiased assessment of ecological condition across the entire Great Lakes...

33 CFR 165.731 - Safety/Security Zone: Cumberland Sound, Georgia and St. Marys River Entrance Channel.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Safety/Security Zone: Cumberland... Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY REGULATED... Seventh Coast Guard District § 165.731 Safety/Security Zone: Cumberland Sound, Georgia and St. Marys River...

Concept And Its Implementation During The Reconstruction Of The Church Of Blessed Virgin Mary In Chojna

Science.gov (United States)

Płotkowiak, Maciej

2015-12-01

St. Mary's parish church in Chojna was erected at the turn of XIV and XVc. in a shape of three aisles, hall church without transept, completed from the west with a single tower and from the east with polygonal presbytery with an ambulatory attached. The convergence of characteristic structural and decorative features with employed ones in medieval churches being attributed to Hinrich Brunsberg's fabric resulted in such a way, that also authorship of St. Mary in Chojna was assigned to this legendary architect and master builder of late Middle Ages period. The church was destroyed by fire during WWII in February 1945 and since then had remained as an open ruin. In 1997 reconstruction procedure of the church was begun under the leadership of the author and it still continues. This text consists of the sum of experiences connected with confronting design ideas and solutions with their executions on the site during construction works.

Marie Curie, les femmes et la science, d'hier à aujourd'hui - English

CERN Multimedia

CERN. Geneva

2017-01-01

Marie Curie, les femmes et la science, d'hier à aujourd'hui Conférence par Hélène Langevin-Joliot Avec la participation de l'Echo du Reculet de Thoiry. L'enregistrement et la liste d'attente sont déjà complets... Mais il n'est pas rare que des personnes réservent et ne viennent pas. Nous réassignerons les places libérées selon la règle "premier arrivé, premier inscrit". Nous envisageons la possibilité de faire un webcast de la conférence. Plus d'information bientôt. Hélène Langevin-Joliot, directrice de recherche émérite en physique nucléaire fondamentale au CNRS à Orsay, est aussi la fille de Frédéric et Irène Joliot-Curie (prix Nobel de chimie en 1935) et la petite-fille de Pierre Curie (prix Nobel de physique en 1903) et de Marie Curie (prix Nobel de physique en 1903 et prix Nobel de chimie en 1911). Hélène Langevin-Joliot nous parlera de sa vie scientifique, de l’histoire extraordinaire de sa famille et en particulier du rôle des ...

Effective cauda equina decompression in two siblings with Charcot-Marie-Tooth disease type 1B

NARCIS (Netherlands)

van Doormaal, Tristan P C; van Ruissen, Fred; Miller, Kai J; Hoogendijk, Jessica E

2016-01-01

Two siblings with Charcot-Marie-Tooth (CMT) 1B due to a c.517G>C (p.Gly173Arg) mutation in the MPZ gene both developed an acute cauda syndrome with unbearable back pain radiating to both legs, progressive muscle weakness of the legs, and saddle hypesthesia with fecal and urinary incontinence. MRI

Search for the signature of a halo structure in the p(6He,6Li)n reaction

International Nuclear Information System (INIS)

Cortina-Gil, M.D.; Roussel-Chomaz, P.; Mittig, W.; Casandjian, J.M.; Chartier, M.; Alamanos, N.; Auger, F.; Fekou-Youmbi, V.; Blumenfeld, Y.; and others.

1995-01-01

The elastic scattering p( 6 He, 6 He)p and charge exchange reaction p( 6 He, 6 Li)n have been measured in reverse kinematics with a secondary 6 He beam. The angular distributions for these reactions were obtained. In the case of the charge exchange reaction, the ratio of the cross section for the Gamow-Teller transition to the ground state, and for the Fermi transition to the isobaric analog state is a measure of the relative strength of the two components of the exchange interaction. This ratio is found compatible with existing systematics for stable T=1 nuclei, and no clear signature of a halo structure was found in the present data. (author)

Mary Ellen Avery’s Research Career- Remembrance of Things Past

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John Steven Torday

2014-04-01

Full Text Available Mary Ellen Avery’s research is recognized as a milestone in biomedical research. She had discovered the underlying cause of Hyaline Membrane Disease, surfactant deficiency, fostering ever more vigorous efforts to reduce neonatal mortality in the burgeoning practice of Neonatology. Neonatology is the only clinical discipline that began as an experiment, making it a model for biomedical research. Avery knew that the concerted effort to treat preterm newborns could potentially do more harm than good, violating her oath to Hippocrates, if not held to the highest scientific standards. She remained true to that pledge throughout her career, as recounted in this Review.

VISIONARY THINKER: LEADERSHIP AND MANAGEMENT IN WORKS OF MARY P. FOLLETT – LONG-TERM PERSPECTIVE IN THE COMPANIES OF THE REPUBLIC OF SERBIA

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Srdjan Nikezic

2014-06-01

Full Text Available In her lectures, Mary P. Follett pointed to key moments of leadership, management, group membership, coordination and participation as relevant elements for the exploration of human relations that are of interest today in the same way as they were eighty years ago. Model of thinking applied by Mary P. Follett is deeply linked to current strong needs for the creation of leadership and management professions that are linked to changes and long term strategic goals of big companies and world economy as a whole.

Quando "falha a fala" e "fala a bala": lingua(gem e violência em Cidade de Deus, de Paulo Lins

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Rita Gabrielli Pereira

2018-04-01

Full Text Available Cidade de Deus traz em si a história da construção do conjunto habitacional, cujo nome intitula o romance, e de sua transformação em uma das favelas mais violentas do Rio de Janeiro, por meio do entrecruzamento das histórias de Cabeleira, Bené, Zé Pequeno e Busca-Pé. Concebendo o romance, nos atos da escrita e da leitura, como uma enunciação (BENVENISTE, 1989a; 1989b; 1995a; 1995b entre autor e leitor, constituída por outras enunciações — entre narrador e narratário e entre personagens — a partir do "ato ficcional" (ISER, 2002 do autor, vamos nos guiar por essa tessitura de/entre histórias para rastrear o modo como Lins relaciona linguagem e violência. Palavras-chave: Lingua(gem, Subjetividade, Violência ______________________________ Cidade de Deus tells the history of the construction of the housing complex that entitles the novel and its transformation process into one of the most violent slums of Rio de Janeiro. By treating the novel as an enunciation (BENVENISTE, 1989a; 1989b; 1995a; 1995b between author and reader, which is made of other enunciations − between narrator and narratee and between characters −, based on the author´s “fictional act”(ISER, 2002, we intend to analyze the way how Lins relates language and violence. Keywords: Language, Subjectivity, Violence.

In search of the Holy Presence of the Blessed Mary in Tolkien’s Middle-earth

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Farid Mohammadi

2013-05-01

Full Text Available The presence of the Catholic framework in J.R.R. Tolkien’s legendarium has long been the subject of debate. Various Tolkien scholars and literary critics have already written different critical interpretations to consider whether to assign The Lord of the Rings and The Silmarillion to Christian Mythology or not; numerous attempts have been made to clarify this statement. Therefore, the reasons, why it should be included in this category are many and various. There are several examples in Tolkien’s The Lord of the Rings that can be studied in relation to Christian themes and motives. Consequently, the aims of this paper are to study the possible similarities of Varda, Queen of the Stars, and Galadriel, the Lady of Light, to the Blessed Virgin Mary in Christian contexts. Moreover, to study the influence of Tolkien’s strong faith, which shaped his Catholic imagination, all through his legendarium, and subsequently leads us to observe Tolkien’s complete obedience to Catholicism, and especially, his profound devotion to the Blessed Virgin Mary.

Limiter discriminator detection of M-ary FSK signals

Science.gov (United States)

Fonseka, John P.

1990-10-01

The performance of limiter discriminator detection of M-ary FSK signals is analyzed at arbitrary modulation indices. It is shown that the error rate performance of limiter discriminator detection can be significantly improved by increasing the modulation index above 1/M. The optimum modulation index that minimizes the overall error probability is determined for the cases M = 2, 4 and 8. The analysis is carried out for wideband and bandlimited channels with Gaussian and second-order Butterworth filters. It is shown that the optimum modulation index depends on the signal/noise ratio (SNR), in a wideband channel, and on both SNR and time-bandwidth product in a bandlimited channel. Finally, it is shown that the optimum sampling instance in presence of a nonzero phase IF filter can be approximately determined by using only the worst case symbol pattern.

Deliberated opinion of the Environment Authority concerning the renewal of the authorization of exploitation of the ANDRA's underground research laboratory in Bure (Meuse)

International Nuclear Information System (INIS)

2010-01-01

This report presents and discusses the documents provided by ANDRA for a renewal authorization request for a basic nuclear installation (INB), ECRIN, aimed at the confined warehousing of residues produced by uranium conversion (transformation into uranium tetrafluoride before its use and implementation as nuclear fuel). The report presents the location and the concerned activity, the different decantation and evaporation basins of the site, the objectives and characteristics of the COMURHEX II project. It indicates the different administrative procedures related to this project, and comments the projected works. It outlines the main environmental issues. It analyses and discusses the impact study which comes along with the request, and comprises an analysis of the initial condition (climate, flooding risk, wildlife, flora, landscapes, water, present impacts of site exploitation on the environment and health). It discusses the search for alternative solutions and the retained choice, the content of the dismantling plan, the impacts of the project (during construction and operation), the approach to risk management, follow-up measures, and the content of the non-technical abstract

Mapping Femininity as Self-reflection Strategy in Lady Mary Wortley Montagu’s Travel Letters

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Amelia Precup

2017-07-01

Full Text Available The present paper participates in the discussion about the differences between masculine and feminine modes of travel in terms of interests, perception, and representation, by exploring the Letters of the Right Honourable Lady M--y W--y M--e Written during Her Travels in Europe, Asia and Africa, by Lady Mary Wortley Montagu. As a traveller, Lady Mary engaged in the contemplation of cultural landscapes: she attempted to understand the social logic of the communities she met and to assess the cultural distance between the English society and the local customs of the countries she visited. Within this large social and cultural framework, the focus of her keen spirit of observation is represented, in many of her letters, by gender dynamics and the status of women, thus allowing a feminine configuration of the map of continental Europe and the Ottoman Empire and a comparative understanding of femininity and expected feminine behaviour. Therefore, the contention of this paper is that, in Lady Mary’s letters, the female-traveller’s gaze ends in meditation and self-contemplation, and functions as a means of comparing and reassessing female identity.

In search of the Boston Strangler: genetic evidence from the exhumation of Mary Sullivan.

Science.gov (United States)

Foran, David R; Starrs, James E

2004-01-01

The Boston Strangler was one of the United States' most notorious serial killers, raping and strangling with decorative ligatures thirteen woman in Boston during the early 1960s. Albert DeSalvo, never a suspect in the slayings, confessed in prison (where he was later murdered) to being the Boston Strangler, and the investigation largely ended. Mary Sullivan was the last victim of the Boston Strangler, found sexually assaulted and strangled in her Boston apartment in 1964. Recently, a team of forensic scientists undertook the exhumation and subsequent scientific analysis of Mary Sullivan's remains, in hope of finding consistencies or inconsistencies between DeSalvo's confessed description of the murder and any evidence left behind. Included in these analyses was extensive DNA testing of all UV fluorescent material associated with the body. The large majority of results were negative, however, fluorescent material located on the underwear and entwined in her pubic hair generated two human mitochondrial DNA sequences. Neither of these matched the victim nor members of the forensic team who worked on the evidence. Most importantly, neither DNA sequence could have originated from Albert DeSalvo.

CHARCOT-MARIE-TOOTH DISEASE

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Lea Leonardis

2003-09-01

Full Text Available Background. Charcot-Marie-Tooth (CMT disease is a common inherited disorder of the peripheral nervous system. In our paper, different types of CMT are described with their typical clinical pictures, electrophysiological signs and molecular genetic studies. CMT is classified as demyelinative and axonal type and distal motor neuronopathy.Conclusions. CMT can be of autosomal dominant, recessive and X-linked inheritance. The most frequent form of CMT is the result of the dominantly inherited duplication of chromosome 17p11.2 and is marked as CMT1A. The same group involves also rare patients with point mutation in the peripheral myelin protein-22 gene. CMT1B is associated with point mutations in protein zero gene. CMT1C is linked to chromosome 16p13.1–12.3. Patients with point mutations in early growth response 2 gene (EGR2 are included in group CMT1D. The disease can be also inhereted X-linked (CMTX with the mutations in connexin-32 gene. In autosomal recessive inherited demyelinating polyneuropathies (CMT4, mutations are found in the myotubularin-related protein-2 (CMT4B, N-myc downstream-regulated gene 1 (CMT4D, EGR2 (CMT4E, and in the periaksin (CMT4F genes. In axonal inherited neuropathy, mutations are found in KIF1beta (CMT2A and in light neurofilament (CMT2E genes, other forms map to different chromosomal loci (CMT2B, CMT2D, CMT2F. Some suggestions for the diagnostic procedures of patients with CMT are given.

Mary Lincoln's Madness: Understanding the Factors that Influence the Diagnosis and Treatment of Bipolar Disorder

Science.gov (United States)

Dick, Carina; Renes, Susan L.; Strange, Anthony T.

2010-01-01

Mary Lincoln, wife of President Abraham Lincoln, lived a tragic life. Beginning with the death of her mother when she was a little girl, Mrs. Lincoln experienced a number of family deaths, including three brothers, three sons, and the murder of her beloved husband while she sat by his side. In addition to tragedy, Mrs. Lincoln suffered from poor…

La quête romantique de trois voyageurs : History of a Six Weeks’ Tour de Mary Shelley

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Caroline VARENNE

2005-06-01

Full Text Available Le court récit de voyage qui nous intéresse fut publié anonymement en 1817. Son titre complet était History of a Six Weeks’ Tour through a Part of France, Switzerland, Germany, and Holland: with Letters Descriptive of a Sail round the Lake of Geneva, and of the Glaciers of Chamouni. Les deux auteurs, Mary et Percy Shelley, pensaient qu’on ne les identifierait jamais. C’est pourtant Mary Shelley qui révéla des années plus tard ce qui n’était plus vraiment un secret, en insérant le récit dans s...