WorldWideScience

Sample records for anchoring

  1. Anchor Modeling

    Science.gov (United States)

    Regardt, Olle; Rönnbäck, Lars; Bergholtz, Maria; Johannesson, Paul; Wohed, Petia

    Maintaining and evolving data warehouses is a complex, error prone, and time consuming activity. The main reason for this state of affairs is that the environment of a data warehouse is in constant change, while the warehouse itself needs to provide a stable and consistent interface to information spanning extended periods of time. In this paper, we propose a modeling technique for data warehousing, called anchor modeling, that offers non-destructive extensibility mechanisms, thereby enabling robust and flexible management of changes in source systems. A key benefit of anchor modeling is that changes in a data warehouse environment only require extensions, not modifications, to the data warehouse. This ensures that existing data warehouse applications will remain unaffected by the evolution of the data warehouse, i.e. existing views and functions will not have to be modified as a result of changes in the warehouse model.

  2. Susceptibility to anchoring effects

    Directory of Open Access Journals (Sweden)

    Todd McElroy

    2007-02-01

    Full Text Available Previous research on anchoring has shown this heuristic to be a very robust psychological phenomenon ubiquitous across many domains of human judgment and decision-making. Despite the prevalence of anchoring effects, researchers have only recently begun to investigate the underlying factors responsible for how and in what ways a person is susceptible to them. This paper examines how one such factor, the Big-Five personality trait of openness-to-experience, influences the effect of previously presented anchors on participants' judgments. Our findings indicate that participants high in openness-to-experience were significantly more influenced by anchoring cues relative to participants low in this trait. These findings were consistent across two different types of anchoring tasks providing convergent evidence for our hypothesis.

  3. The anchor integration model: A descriptive model of anchoring effects.

    Science.gov (United States)

    Turner, Brandon M; Schley, Dan R

    2016-11-01

    Few experimental effects in the psychology of judgment and decision making have been studied as meticulously as the anchoring effect. Although the existing literature provides considerable insight into the psychological processes underlying anchoring effects, extant theories up to this point have only generated qualitative predictions. While these theories have been productive in advancing our understanding of the underlying anchoring process, they leave much to be desired in the interpretation of specific anchoring effects. In this article, we introduce the Anchor Integration Model (AIM) as a descriptive tool for the measurement and quantification of anchoring effects. We develop two versions the model: one suitable for assessing between-participant anchoring effects, and another for assessing individual differences in anchoring effects. We then fit each model to data from two experiments, and demonstrate the model's utility in describing anchoring effects. Copyright © 2016 Elsevier Inc. All rights reserved.

  4. The Anchoring Concept

    DEFF Research Database (Denmark)

    Simonsen, Jesper

    1998-01-01

    This paper introduces the term 'anchoring' within systems development: Visions, developed through early systems design within an organization, need to be deeply rooted in the organization. A vision's rationale needs to be understood by those who decide if the vision should be implemented as well ...

  5. Anchored paired comparisons

    Science.gov (United States)

    Dalal, E. N.; Handley, J. C.; Wu, W.; Wang, J.

    2008-01-01

    The method of paired comparisons is often used in image quality evaluations. Psychometric scale values for quality judgments are modeled using Thurstone's Law of Comparative Judgment in which distance in a psychometric scale space is a function of the probability of preference. The transformation from psychometric space to probability is a cumulative probability distribution. The major drawback of a complete paired comparison experiment is that every treatment is compared to every other, thus the number of comparisons grows quadratically. We ameliorate this difficulty by performing paired comparisons in two stages, by precisely estimating anchors in the psychometric scale space which are spaced apart to cover the range of scale values and comparing treatments against those anchors. In this model, we employ a generalized linear model where the regression equation has a constant offset vector determined by the anchors. The result of this formulation is a straightforward statistical model easily analyzed using any modern statistics package. This enables model fitting and diagnostics. This method was applied to overall preference evaluations of color pictorial hardcopy images. The results were found to be compatible with complete paired comparison experiments, but with significantly less effort.

  6. Anchoring visions in organizations

    DEFF Research Database (Denmark)

    Simonsen, Jesper

    1999-01-01

    This paper introduces the term 'anchoring' within systems development: Visions, developed through early systems design within an organization, need to be deeply rooted in the organization. A vision's rationale needs to be understood by those who decide if the vision should be implemented as well...... as by those involved in the actual implementation. A model depicting a recent trend within systems development is presented: Organizations rely on purchasing generic software products and/or software development outsourced to external contractors. A contemporary method for participatory design, where...

  7. Career anchors of dentist leaders.

    Science.gov (United States)

    Tuononen, Tiina; Lammintakanen, Johanna; Suominen, Anna Liisa

    2016-08-01

    The work of a health care leader is demanding; in order to cope, leaders need motivation and support. The occurrence of intrinsic factors called career anchors (combination of one's competence, motives and values) could be a contributing factor in dentist leaders' career decisions. The aim of our study was to identify dentist leaders' career anchors and their association to dentist leaders' retention or turnover of the leadership position. Materials were gathered in 2014 via an electronic questionnaire from 156 current (Leaders) or former (Leavers) Finnish dentist leaders. Career anchor evaluation was conducted by the questionnaire and scoring-table taken from Edgar Schein's Career Anchors Self-Assessment. Both the most and the least important career anchors were detected by the highest and lowest scores and their occurrence reported as percentages. Associations between career anchor scores and tendency to stay were analyzed with logistic regression. 'Technical/Functional Competence' and 'Lifestyle' were most frequently reported as the most important and 'Entrepreneurial Creativity' and 'General Managerial Competence' as the least important career anchors. However, a higher level of 'General Managerial Competence' anchor was most significantly associated with staying in a leadership position. Instead, 'Pure Challenge' and 'Lifestyle' decreased the odds to stay. The knowledge of the important and essential career anchors of dentist leaders' and individuals' could perform crucial part in career choices and also in planning education, work opportunities and human resource policies promoting retention of dentist leaders and probably also other health care leaders.

  8. The Holding Power of Anchors

    Indian Academy of Sciences (India)

    ton cutter Frolic. One thing is certain, however, the new anchor has no stock to foul the jib sheets when coming about, so that one continuously acting source of blasphemy will be removed. For the benefit of people who like to try new things, it is proposed to put this anchor on the market at the beginning of the coming season ...

  9. Not all Anchors Weigh Equally.

    Science.gov (United States)

    Greenstein, Michael; Velazquez, Alexandra

    2017-11-01

    The anchoring bias is a reliable effect wherein a person's judgments are affected by initially presented information, but it is unknown specifically why this effect occurs. Research examining this bias suggests that elements of both numeric and semantic priming may be involved. To examine this, the present research used a phenomenon wherein people treat numeric information presented differently in Arabic numeral or verbal formats. We presented participants with one of many forms of an anchor that represented the same value (e.g., twelve hundred or 1,200). Thus, we could examine how a concept's meaning and its absolute numeric value affect anchoring. Experiments 1 and 2 showed that people respond to Arabic and verbal anchors differently. Experiment 3 showed that these differences occurred largely because people tend to think of numbers in digit format. This suggests that one's conceptual understanding of the anchored information matters more than its strict numeric value.

  10. Bone Anchored Hearing Aid

    Science.gov (United States)

    2002-01-01

    Executive Summary Objective The objective of this health technology policy assessment was to determine the effectiveness and cost-effectiveness of bone-anchored hearing aid (BAHA) in improving the hearing of people with conduction or mixed hearing loss. The Technology The (BAHA) is a bone conduction hearing device that includes a titanium fixture permanently implanted into the mastoid bone of the skull and an external percutaneous sound processor. The sound processor is attached to the fixture by means of a skin penetrating abutment. Because the device bypasses the middle ear and directly stimulates the cochlea, it has been recommended for individuals with conduction hearing loss or discharging middle ear infection. The titanium implant is expected to last a lifetime while the external sound processor is expected to last 5 years. The total initial device cost is approximately $5,300 and the external sound processor costs approximately $3,500. Review of BAHA by the Medical Advisory Secretariat The Medical Advisory Secretariat’s review is a descriptive synthesis of findings from 36 research articles published between January 1990 and May 2002. Summary of Findings No randomized controlled studies were found. The evidence was derived from level 4 case series with relative small sample sizes (ranging from 30-188). The majority of the studies have follow-up periods of eight years or longer. All except one study were based on monaural BAHA implant on the side with the best bone conduction threshold. Safety Level 4 evidence showed that BAHA has been be implanted safely in adults and children with success rates of 90% or higher in most studies. No mortality or life threatening morbidity has been reported. Revision rates for tissue reduction or resiting were generally under 10% for adults but have been reported to be as high as 25% in pediatric studies. Adverse skin reaction around the skin penetration site was the most common complication reported. Most of these

  11. The Holding Power of Anchors

    Indian Academy of Sciences (India)

    as the chain begins to drag along the ground; and it also serves, by lying flat on the ground, to keep the palm set at the correct angle as it buries itself. In stockless anchors there are two digging blades set on opposite sides of the shank, and hinged to it by a horizontal hinge which allows them to set themselves at the correct.

  12. Nominal Anchors in the CIS

    OpenAIRE

    Peter M Keller; Thomas J Richardson

    2003-01-01

    Monetary policy has become increasingly important in the countries of the Commonwealth of Independent States (CIS) as fiscal adjustment and structural reforms have taken root. Inflation has been brought down to relatively low levels in almost all of these countries, raising the question of what should be the appropriate nominal anchor at this stage. Formally, almost all CIS countries have floating exchange rate regimes, yet in practice they manage their exchange rates very heavily, perhaps be...

  13. [Bone-anchored auricular prosthesis].

    Science.gov (United States)

    Bille, M; Homøe, P; Vesterhauge, S; Rixen, M; Bretlau, P

    1994-10-03

    During the period February 1989-September 1991, 15 patients with absent or defective pinna were treated with a bone-anchored auricular prosthesis at the ENT-department, Rigshospitalet, Copenhagen. These patients were followed up from the hospital records and by means of a questionnaire. Altogether 40 titanium implants have been inserted, of which one implant was found not to be integrated at the time of the second-stage surgery. Five patients underwent additional surgery, one patient because of non-integration of a screw, and four patients on account of soft-tissue reactions. From the questionnaire replies it appears that all patients found the cosmetic result and the technique concerning mounting of the prosthesis very satisfactory. Nearly half the patients found that the care of the skin around the abutments caused considerable problems. Three patients had experienced unintended losses of the prosthesis. In conclusion, treatment with a bone anchored auricular prosthesis has considerable advantages compared to treatment with a prosthesis attached by adhesive. Furthermore the use of a bone-anchored prosthesis should be considered a viable alternative to surgical reconstruction because of the outstanding aesthetic result and because the surgical procedure puts less strain on the patient. The disadvantage of the method is the lifelong daily care of the skin and the dependence on the health services.

  14. Suction anchors for floating production systems

    Energy Technology Data Exchange (ETDEWEB)

    Tjelta, T.I.; Rusas, P. [Statoil a.s. (Norway); Edvardsen, G. [HEX a.s. (Norway)

    1996-12-31

    Since the suction anchor is a recent development in its current use, this work provides a brief historical background. It is shown that the suction anchor throughout evolution today is a competitive foundation solution for many applications. Examples from these categories are included in this paper. Also several installation methods are discussed. 3 refs., 7 figs., 2 tabs.

  15. Anchors of Religious Commitment in Adolescents

    Science.gov (United States)

    Layton, Emily; Dollahite, David C.; Hardy, Sam A.

    2011-01-01

    This study explores adolescent religious commitment using qualitative data from a religiously diverse (Jewish, Christian, Muslim) sample of 80 adolescents. A new construct, "anchors of religious commitment," grounded in interview data, is proposed to describe what adolescents commit to as a part of their religious identity. Seven anchors of…

  16. 21 CFR 872.3130 - Preformed anchor.

    Science.gov (United States)

    2010-04-01

    ... DEVICES DENTAL DEVICES Prosthetic Devices § 872.3130 Preformed anchor. (a) Identification. A preformed anchor is a device made of austenitic alloys or alloys containing 75 percent or greater gold or metals of the platinum group intended to be incorporated into a dental appliance, such as a denture, to help...

  17. Anchoring effects on early autobiographical memories.

    Science.gov (United States)

    Greenberg, Daniel L; Bishara, Anthony J; Mugayar-Baldocchi, Marino A

    2017-10-01

    Studies of childhood memory typically show that our earliest memories come from between three and four years of age. This finding is not universal, however. The age estimate varies across cultures and is affected by social influences. Research from the judgments and decision-making literature suggests that these estimates might also involve a judgment under uncertainty. Therefore, they might be susceptible to less social influences such as heuristics and biases. To investigate this possibility, we conducted two experiments that used anchoring paradigms to influence participants' estimates of their age during early autobiographical memories. In Experiment 1, participants answered either a high-anchor or a low-anchor question, and were warned that the anchor was uninformative; they went on to estimate their age during their earliest autobiographical memory. In Experiment 2, we replicated Experiment 1 and extended the design to examine additional early autobiographical memories. In both experiments, participants in the low-anchor condition gave earlier age estimates than those in the high-anchor condition. These results provide new insights into the methods used to investigate autobiographical memory. Moreover, they show that reports of early autobiographical memories can be influenced by a relatively light touch - a change to a single digit in a single question.

  18. The Use of Comics-Based Cases in Anchored Instruction

    Science.gov (United States)

    Kneller, Matthew F.

    2009-01-01

    The primary purpose of this research was to understand how comics fulfill the role of anchor in an anchored instruction learning environment. Anchored instruction addresses the inert knowledge problem through the use of realistic multimedia stories, or "anchors," that embed a problem and the necessary data to solve it within the narrative. In the…

  19. Career anchors and learning plan (part one

    Directory of Open Access Journals (Sweden)

    Daniela Brečko

    2006-12-01

    Full Text Available The article is divided into three parts. The first part concentrates on how important career is for an individual, organization and society. The author establishes that understanding of career has changed dramatically and does not only refer to climbing up the career ladder, but also moving off or even down the career ladder. The notion of career, as a lifelong and professional path, encompasses all aspects of human personality and their roles acquired through one's life. On basis of vast and longitudinal research, where the author has studied career anchors of individuals, it is the objective of the author to find out on basis of what grounds do the individuals decide to take certain directions in their careers and how learning contributes to such decisions. As a source the author has used Shein's theory of career anchors. Part one describes in greater detail 8 different career anchors and introduces their main features with the findings of the research, which refer to the analysis of professions (work positions and established career anchors. The author thus verifies the hypothesis that career anchors do exist in our area.

  20. Ultimate load capacities of expansion anchor bolts

    International Nuclear Information System (INIS)

    Czarnecki, R.M.; Manrique, M.A.; Samaddar, S.K.

    1993-01-01

    A summary of available experimental expansion anchor bolt test data is presented. These data were collected as part of programs by the nuclear industry to address generic issues related to verification of seismic adequacy of equipment in nuclear power plants. Some of the data presented are suitable for use in seismic probabilistic risk assessments. For example, mean values of ultimate strength, along with their standard deviation and coefficients of variation, for a range of most typical expansion anchor bolt sizes are presented. Effects of interaction between shear and tension, edge distance, spacing, and cracking of the concrete are presented in a manner that is more suitable for use in deterministic evaluations. Related industry programs to derive anchor bolt capacities are briefly discussed. Recommendations for areas of further investigation are also presented

  1. Monogenean anchor morphometry: systematic value, phylogenetic signal, and evolution

    Directory of Open Access Journals (Sweden)

    Tsung Fei Khang

    2016-02-01

    Full Text Available Background. Anchors are one of the important attachment appendages for monogenean parasites. Common descent and evolutionary processes have left their mark on anchor morphometry, in the form of patterns of shape and size variation useful for systematic and evolutionary studies. When combined with morphological and molecular data, analysis of anchor morphometry can potentially answer a wide range of biological questions. Materials and Methods. We used data from anchor morphometry, body size and morphology of 13 Ligophorus (Monogenea: Ancyrocephalidae species infecting two marine mugilid (Teleostei: Mugilidae fish hosts: Moolgarda buchanani (Bleeker and Liza subviridis (Valenciennes from Malaysia. Anchor shape and size data (n = 530 were generated using methods of geometric morphometrics. We used 28S rRNA, 18S rRNA, and ITS1 sequence data to infer a maximum likelihood phylogeny. We discriminated species using principal component and cluster analysis of shape data. Adams’s Kmult was used to detect phylogenetic signal in anchor shape. Phylogeny-correlated size and shape changes were investigated using continuous character mapping and directional statistics, respectively. We assessed morphological constraints in anchor morphometry using phylogenetic regression of anchor shape against body size and anchor size. Anchor morphological integration was studied using partial least squares method. The association between copulatory organ morphology and anchor shape and size in phylomorphospace was used to test the Rohde-Hobbs hypothesis. We created monogeneaGM, a new R package that integrates analyses of monogenean anchor geometric morphometric data with morphological and phylogenetic data. Results. We discriminated 12 of the 13 Ligophorus species using anchor shape data. Significant phylogenetic signal was detected in anchor shape. Thus, we discovered new morphological characters based on anchor shaft shape, the length between the inner root point and the

  2. Monogenean anchor morphometry: systematic value, phylogenetic signal, and evolution.

    Science.gov (United States)

    Khang, Tsung Fei; Soo, Oi Yoon Michelle; Tan, Wooi Boon; Lim, Lee Hong Susan

    2016-01-01

    Background. Anchors are one of the important attachment appendages for monogenean parasites. Common descent and evolutionary processes have left their mark on anchor morphometry, in the form of patterns of shape and size variation useful for systematic and evolutionary studies. When combined with morphological and molecular data, analysis of anchor morphometry can potentially answer a wide range of biological questions. Materials and Methods. We used data from anchor morphometry, body size and morphology of 13 Ligophorus (Monogenea: Ancyrocephalidae) species infecting two marine mugilid (Teleostei: Mugilidae) fish hosts: Moolgarda buchanani (Bleeker) and Liza subviridis (Valenciennes) from Malaysia. Anchor shape and size data (n = 530) were generated using methods of geometric morphometrics. We used 28S rRNA, 18S rRNA, and ITS1 sequence data to infer a maximum likelihood phylogeny. We discriminated species using principal component and cluster analysis of shape data. Adams's K mult was used to detect phylogenetic signal in anchor shape. Phylogeny-correlated size and shape changes were investigated using continuous character mapping and directional statistics, respectively. We assessed morphological constraints in anchor morphometry using phylogenetic regression of anchor shape against body size and anchor size. Anchor morphological integration was studied using partial least squares method. The association between copulatory organ morphology and anchor shape and size in phylomorphospace was used to test the Rohde-Hobbs hypothesis. We created monogeneaGM, a new R package that integrates analyses of monogenean anchor geometric morphometric data with morphological and phylogenetic data. Results. We discriminated 12 of the 13 Ligophorus species using anchor shape data. Significant phylogenetic signal was detected in anchor shape. Thus, we discovered new morphological characters based on anchor shaft shape, the length between the inner root point and the outer root

  3. Heat-Conducting Anchors for Thermocouples

    Science.gov (United States)

    Macdavid, Kenton S.

    1987-01-01

    Metal particles in adhesive aid heat transfer. Aluminum caps containing silver-filled epoxy used as high-thermal-conductance anchors for thermocouples, epoxy providing thermal path between mounting surfaces and thermocouple measuring junctions. Normally, epoxy-filled aluminum caps used when measuring steady-state temperatures. Silver-filled epoxy used when thermocouple not isolated electrically from surface measured.

  4. Anchoring Singapore Philanthropy in Southeast Asia | CRDI ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Anchoring Singapore Philanthropy in Southeast Asia. Philanthropy in Singapore has traditionally had a charitable and local orientation. However, given the country's growing wealth and strong ties (trade, investment, migration) with its less advantaged neighbours, it is expected that considerable philanthropic capital will ...

  5. Anchoring Singapore Philanthropy in Southeast Asia | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Anchoring Singapore Philanthropy in Southeast Asia. Philanthropy in Singapore has traditionally had a charitable and local orientation. However, given the country's growing wealth and strong ties (trade, investment, migration) with its less advantaged neighbours, it is expected that considerable philanthropic capital will ...

  6. The bone-anchored hearing aid

    DEFF Research Database (Denmark)

    Foghsgaard, Søren

    2014-01-01

    The bone-anchored hearing aid (Baha) was introduced in 1977 by Tjellström and colleagues and has now been used clinically for over 30 years. Generally, the outcomes are good, and several studies have shown improved audiological- and quality of life outcomes. The principle of the Baha is, that sound...

  7. Anchoring the Panic Disorder Severity Scale

    Science.gov (United States)

    Keough, Meghan E.; Porter, Eliora; Kredlow, M. Alexandra; Worthington, John J.; Hoge, Elizabeth A.; Pollack, Mark H.; Shear, M. Katherine; Simon, Naomi M.

    2012-01-01

    The Panic Disorder Severity Scale (PDSS) is a clinician-administered measure of panic disorder symptom severity widely used in clinical research. This investigation sought to provide clinically meaningful anchor points for the PDSS both in terms of clinical severity as measured by the Clinical Global Impression-Severity Scale (CGI-S) and to extend…

  8. Chemical biology of Glycosylphosphatidylinositol (GPI) anchors

    Indian Academy of Sciences (India)

    Admin

    CSIR-IIIM. Chemical biology of. Glycosylphosphatidylinositol (GPI) anchors. Ram Vishwakarma. CSIR-Indian Institute of Integrative Medicine, Jammu. N ti l I tit t f I l. N. D lhi. National Institute of Immunology, New Delhi. Piramal Life Sciences Ltd, Mumbai ...

  9. Influence of Anchoring on Burial Depth of Submarine Pipelines.

    Science.gov (United States)

    Zhuang, Yuan; Li, Yang; Su, Wei

    2016-01-01

    Since the beginning of the twenty-first century, there has been widespread construction of submarine oil-gas transmission pipelines due to an increase in offshore oil exploration. Vessel anchoring operations are causing more damage to submarine pipelines due to shipping transportation also increasing. Therefore, it is essential that the influence of anchoring on the required burial depth of submarine pipelines is determined. In this paper, mathematical models for ordinary anchoring and emergency anchoring have been established to derive an anchor impact energy equation for each condition. The required effective burial depth for submarine pipelines has then been calculated via an energy absorption equation for the protection layer covering the submarine pipelines. Finally, the results of the model calculation have been verified by accident case analysis, and the impact of the anchoring height, anchoring water depth and the anchor weight on the required burial depth of submarine pipelines has been further analyzed.

  10. Experimental Research on Destruction Mode and Anchoring Performance of Carbon Fiber Phyllostachys pubescens Anchor Rod with Different Forms

    Directory of Open Access Journals (Sweden)

    Wang Yulan

    2018-01-01

    Full Text Available The anchoring technology is extensively applied in reinforcing protection of the earth relics. Now that no specification is available for different new anchor rods in earth relics protection due to diversified destruction modes of earth relics and complexity of engineering technology conditions, it is urgent to guide reinforcing design and construction with a complete detailed anchor rod research document. With the new carbon fiber Phyllostachys pubescens anchor rod as the research object, six lots of in situ tests are designed to, respectively, study the destruction mode and anchoring performance of the carbon fiber Phyllostachys pubescens anchor rod under different anchor length L, anchor rod diameter D, bore diameter H, grouting material S, rib spacing R, and inclination angle A in this paper. By studying load shift curve experiment in drawing of the anchor rod, the destruction mode and ultimate bearing capacity of the carbon fiber Phyllostachys pubescens anchor rod in different experiment lots are obtained, and the concept of permitted application value N in anchor rod design is proposed. By studying strain distribution characteristics of anchor rods in experimental lots along the length direction under action of the permitted application value N and combining the existing destruction mode and ultimate bearing capacity, this paper analyzes influences of L, D, H, S, R, and A on anchoring effect of the carbon fiber Phyllostachys pubescens anchor rod; gives the reasonable value range of L, D, H, and R when the carbon fiber Phyllostachys pubescens anchor rod is used for reinforcing design of the earth relics; and provides favorable experiment basis for reinforcing design of the earth relics based on the carbon fiber Phyllostachys pubescens anchor rod.

  11. Measures for the Safe Operation of Anchoring in a Storm

    Science.gov (United States)

    Han, Tianding; Ai, Wanzheng

    2018-01-01

    The collision and stranding of ship other shipwreck accidents are mainly caused by the ship dragging. As the water is less in coastal areas, anchoring has less influence on cementing ship, so strong wind is the most important factor for ship anchoring. Therefore, it is very important to study the safety evaluation of mooring in strong wind. In this paper, the measures taken after the ship anchoring is come up with from the analysis on the typical accidents and causes of anchoring security. The safety measures at the time of anchoring are also studied.

  12. Comparative Study on Different Slot Forms of Prestressed Anchor Blocks

    Science.gov (United States)

    Fan, Rong; Si, Jianhui; Jian, Zheng

    2018-03-01

    In this paper, two models of prestressed pier, rectangular cavity anchor block and arch hollow anchor block are established. The ABAQUS software was used to calculate the stress of the surface of the neck of the pier and the cavity of the anchor block, through comparative analysis. The results show that compared with the rectangular cavity anchor block, the stress of the pier and the cavity can be effectively reduced when the arch hole is used, and the amount of prestressed anchor can be reduced, so as to obtain obvious economic benefits.

  13. Composite materials formed with anchored nanostructures

    Science.gov (United States)

    Seals, Roland D; Menchhofer, Paul A; Howe, Jane Y; Wang, Wei

    2015-03-10

    A method of forming nano-structure composite materials that have a binder material and a nanostructure fiber material is described. A precursor material may be formed using a mixture of at least one metal powder and anchored nanostructure materials. The metal powder mixture may be (a) Ni powder and (b) NiAl powder. The anchored nanostructure materials may comprise (i) NiAl powder as a support material and (ii) carbon nanotubes attached to nanoparticles adjacent to a surface of the support material. The process of forming nano-structure composite materials typically involves sintering the mixture under vacuum in a die. When Ni and NiAl are used in the metal powder mixture Ni.sub.3Al may form as the binder material after sintering. The mixture is sintered until it consolidates to form the nano-structure composite material.

  14. Chemical biology of Glycosylphosphatidylinositol (GPI) anchors

    Indian Academy of Sciences (India)

    Admin

    CSIR-IIIM. Chemical biology of GPI anchors. • Organic synthesis, biosynthesis and cell biology of PI/GPI molecules. • Design and synthesis of structural and functional mimics of. PI/GPI t b bi l i l ti. PI/GPIs to probe biological questions. • Targeting PI3K/AKT/mTOR pathway for anticancer drug discovery. • Role of PI3K isoforms ...

  15. Electropermanent magnetic anchoring for surgery and endoscopy.

    Science.gov (United States)

    Tugwell, Josef; Brennan, Philip; O'Shea, Conor; O'Donoghue, Kilian; Power, Timothy; O'Shea, Michael; Griffiths, James; Cahill, Ronan; Cantillon-Murphy, Padraig

    2015-03-01

    The use of magnets for anchoring of instrumentation in minimally invasive surgery and endoscopy has become of increased interest in recent years. Permanent magnets have significant advantages over electromagnets for these applications; larger anchoring and retraction force for comparable size and volume without the need for any external power supply. However, permanent magnets represent a potential hazard in the operating field where inadvertent attraction to surgical instrumentation is often undesirable. The current work proposes an interesting hybrid approach which marries the high forces of permanent magnets with the control of electromagnetic technology including the ability to turn the magnet OFF when necessary. This is achieved through the use of an electropermanent magnet, which is designed for surgical retraction across the abdominal and gastric walls. Our electropermanent magnet, which is hand-held and does not require continuous power, is designed with a center lumen which may be used for trocar or needle insertion. The device in this application has been demonstrated successfully in the porcine model where coupling between an intraluminal ring magnet and our electropermanent magnet facilitated guided insertion of an 18 Fr Tuohy needle for guidewire placement. Subsequent investigations have demonstrated the ability to control the coupling distance of the system alleviating shortcomings with current methods of magnetic coupling due to variation in transabdominal wall thicknesses. With further refinement, the magnet may find application in the anchoring of endoscopic and surgical instrumentation for minimally invasive interventions in the gastrointestinal tract.

  16. Anchored design of protein-protein interfaces.

    Directory of Open Access Journals (Sweden)

    Steven M Lewis

    Full Text Available Few existing protein-protein interface design methods allow for extensive backbone rearrangements during the design process. There is also a dichotomy between redesign methods, which take advantage of the native interface, and de novo methods, which produce novel binders.Here, we propose a new method for designing novel protein reagents that combines advantages of redesign and de novo methods and allows for extensive backbone motion. This method requires a bound structure of a target and one of its natural binding partners. A key interaction in this interface, the anchor, is computationally grafted out of the partner and into a surface loop on the design scaffold. The design scaffold's surface is then redesigned with backbone flexibility to create a new binding partner for the target. Careful choice of a scaffold will bring experimentally desirable characteristics into the new complex. The use of an anchor both expedites the design process and ensures that binding proceeds against a known location on the target. The use of surface loops on the scaffold allows for flexible-backbone redesign to properly search conformational space.This protocol was implemented within the Rosetta3 software suite. To demonstrate and evaluate this protocol, we have developed a benchmarking set of structures from the PDB with loop-mediated interfaces. This protocol can recover the correct loop-mediated interface in 15 out of 16 tested structures, using only a single residue as an anchor.

  17. Resisting anchoring effects: The roles of metric and mapping knowledge.

    Science.gov (United States)

    Smith, Andrew R; Windschitl, Paul D

    2015-10-01

    The biasing influence of anchors on numerical estimates is well established, but the relationship between knowledge level and the susceptibility to anchoring effects is less clear. In two studies, we addressed the potential mitigating effects of having knowledge in a domain on vulnerability to anchoring effects in that domain. Of critical interest was a distinction between two forms of knowledge-metric and mapping knowledge. In Study 1, participants who had studied question-relevant information-that is, high-knowledge participants-were less influenced by anchors than were participants who had studied irrelevant information. The results from knowledge measures suggested that the reduction in anchoring was tied to increases in metric rather than mapping knowledge. In Study 2, participants studied information specifically designed to influence different types of knowledge. As we predicted, increases in metric knowledge-and not mapping knowledge-led to reduced anchoring effects. Implications for debiasing anchoring effects are discussed.

  18. Robotic Ankle for Omnidirectional Rock Anchors

    Science.gov (United States)

    Parness, Aaron; Frost, Matthew; Thatte, Nitish

    2013-01-01

    Future robotic exploration of near-Earth asteroids and the vertical and inverted rock walls of lava caves and cliff faces on Mars and other planetary bodies would require a method of gripping their rocky surfaces to allow mobility without gravitational assistance. In order to successfully navigate this terrain and drill for samples, the grippers must be able to produce anchoring forces in excess of 100 N. Additionally, the grippers must be able to support the inertial forces of a moving robot, as well gravitational forces for demonstrations on Earth. One possible solution would be to use microspine arrays to anchor to rock surfaces and provide the necessary load-bearing abilities for robotic exploration of asteroids. Microspine arrays comprise dozens of small steel hooks supported on individual suspensions. When these arrays are dragged along a rock surface, the steel hooks engage with asperities and holes on the surface. The suspensions allow for individual hooks to engage with asperities while the remaining hooks continue to drag along the surface. This ensures that the maximum possible number of hooks engage with the surface, thereby increasing the load-bearing abilities of the gripper. Using the microspine array grippers described above as the end-effectors of a robot would allow it to traverse terrain previously unreachable by traditional wheeled robots. Furthermore, microspine-gripping robots that can perch on cliffs or rocky walls could enable a new class of persistent surveillance devices for military applications. In order to interface these microspine grippers with a legged robot, an ankle is needed that can robotically actuate the gripper, as well as allow it to conform to the large-scale irregularities in the rock. The anchor serves three main purposes: deploy and release the anchor, conform to roughness or misalignment with the surface, and cancel out any moments about the anchor that could cause unintentional detachment. The ankle design contains a

  19. ANCHORING IN THE POLITICAL AND ECONOMIC MARKETING

    Directory of Open Access Journals (Sweden)

    Tatyana L. Shklyar

    2015-01-01

    Full Text Available The main purpose of marketing, both ineconomy and in politics is to attract themaximum number of customers or voters, maximizing customer satisfaction and ,ideally, improve the quality of life.The author, in various aspects, thetechnology of anchoring used in NLP, to attract customers and voters, both in the economy and in politics.In different examples demonstrate theoverall impact on the psychology of the consumer. Separating policy and the economy, marketers are missing something. The author proposes to look at how psychologicalanchors affect these two, at fi rst glance, different vector.

  20. Stone anchors from Minicoy Island, Lakshadweep, India

    Digital Repository Service at National Institute of Oceanography (India)

    Tripati, S.

    and Ali Rajas of Kerala. It appears that the mainland had contact with these islands during the early centuries of the Christian era, if not earlier (Sila Tripati, 1999). Though Islam came to Lakshadweep after the 11th and 12th centuries AD... by fishermen. In Divehi, the local language, ring-stone anchors are known as fanaa. Of 40–50 cm diameter, they are made of coral fashioned in the form of a slightly concave disc. The width of the hole in which the wooden stock is inserted is 6–10 cm...

  1. BAHA: Bone-Anchored Hearing Aid

    Science.gov (United States)

    Hagr, Abdulrahman

    2007-01-01

    Bone-Anchored Hearing Aid (BAHA) has proven performance and advantages for patients with aural atresia or chronic ear drainage who cannot wear air-conduction hearing aids. The BAHA has both cosmetic and acoustic advantages over most conventional hearing aids and hence is becoming increasingly popular. Moreover, BAHA improves the quality of life and has also significantly reduces ear discharge. This extensive review of the literature pertaining to BAHA discus the history, the indications, the advantages, the prediction of the outcome and the complications of this device as well as comparing it to the conventional hearing aids. PMID:21475438

  2. [The bone-anchored hearing aid].

    Science.gov (United States)

    Foghsgaard, Søren

    2014-08-11

    The bone-anchored hearing aid (Baha) was introduced in 1977 by Tjellström and colleagues and has now been used clinically for over 30 years. Generally, the outcomes are good, and several studies have shown improved audiological- and quality of life outcomes. The principle of the Baha is, that sound vibrations are led directly to the inner ear via the mastoid bone, bypassing the middle ear. This is achieved via an osseointegrated implant and a skin-penetrating abutment. Studies report high success rates and a majority of complications as typically minor in nature.

  3. Adsorption phenomena and anchoring energy in nematic liquid crystals

    CERN Document Server

    Barbero, Giovanni

    2005-01-01

    Despite the large quantity of phenomenological information concerning the bulk properties of nematic phase liquid crystals, little is understood about the origin of the surface energy, particularly the surface, interfacial, and anchoring properties of liquid crystals that affect the performance of liquid crystal devices. Self-contained and unique, Adsorption Phenomena and Anchoring Energy in Nematic Liquid Crystals provides an account of new and established results spanning three decades of research into the problems of anchoring energy and adsorption phenomena in liquid crystals.The book contains a detailed discussion of the origin and possible sources of anchoring energy in nematic liquid crystals, emphasizing the dielectric contribution to the anchoring energy in particular. Beginning with fundamental surface and anchoring properties of liquid crystals and the definition of the nematic phase, the authors explain how selective ion adsorption, dielectric energy density, thickness dependence, and bias voltage...

  4. 24 CFR 3285.402 - Ground anchor installations.

    Science.gov (United States)

    2010-04-01

    ... anchor head from edge of floor or wall. 3. Table is based on main rail (I-beam) spacing per given column... ground anchor head from edge of floor or wall. 3. Tables are based on main rail (I-beam) spacing per... anchor head from edge of floor or wall. 3. Table is based on main rail (I-beam) spacing per given column...

  5. Investigation of suction anchor pullout capacity under undrained conditions

    OpenAIRE

    Jarand, Pollestad

    2015-01-01

    Master's thesis in Offshore technology Floating units are dependent on reliable mooring systems to ensure safety during marine operations. Suction anchors have proved to be a technologically viable and cost-effective concept. They are capable of precision installation, re-use, and provide large resistive capacity. This thesis investigates load capacity and failure modes of suction anchors subjected to vertical, horizontal (lateral), and incline loading. Suction anchor design co...

  6. Moody experts --- How mood and expertise influence judgmental anchoring

    Directory of Open Access Journals (Sweden)

    Birte Englich

    2009-02-01

    Full Text Available Anchoring effects, the assimilation of numerical estimates to previously considered standards, are highly robust. Two studies examined whether mood and expertise jointly moderate the magnitude of anchoring. Previous research has demonstrated that happy mood induces judges to process information in a less thorough manner than sad mood, which means that happy judges tend to be more susceptible to unwanted influences. However, this may not be true for anchoring effects. Because anchoring results from an elaborate process of selective knowledge activation, more thorough processing should lead to more anchoring; as a result, sad judges should show stronger anchoring effects than happy judges and happy judges may even remain uninfluenced by the given anchors. Because information processing of experts may be relatively independent of their mood, however, mood may influence anchoring only in non-experts. Results of two studies on legal decision-making (Study 1 and numeric estimates (Study 2 are consistent with these expectations. These findings suggest that, at least for non-experts, positive mood may eliminate the otherwise robust anchoring effect.

  7. Testing methods of steel wi re ropes at the anchor

    Directory of Open Access Journals (Sweden)

    Stanislav Kropuch

    2012-12-01

    Full Text Available The present paper introduces an application of the acoustic andthermographic method in the defectoscopic testing of immobilesteel wire ropes at the most critical point, the anchor. Firstmeasurements and their results by these new defectoscopic methodsare shown. In defectoscopic tests at the anchor, the widelyused magnetic method gives unreliable results, and therefore presentsa problem for steel wire defectoscopy. Application of the two new methods in the steel wire defectoscopy at the anchor point will enableincreased safety measures at the anchor of steel wire ropes in bridge, roof, tower and aerial cable lift constructions.

  8. Testing and modeling of cyclically loaded rock anchors

    Directory of Open Access Journals (Sweden)

    Joar Tistel

    2017-12-01

    Full Text Available The Norwegian Public Roads Administration (NPRA is planning for an upgrade of the E39 highway route at the westcoast of Norway. Fixed links shall replace ferries at seven fjord crossings. Wide spans and large depths at the crossings combined with challenging subsea topography and environmental loads call for an extension of existing practice. A variety of bridge concepts are evaluated in the feasibility study. The structures will experience significant loads from deadweight, traffic and environment. Anchoring of these forces is thus one of the challenges met in the project. Large-size subsea rock anchors are considered a viable alternative. These can be used for anchoring of floating structures but also with the purpose of increasing capacity of fixed structures. This paper presents first a thorough study of factors affecting rock anchor bond capacity. Laboratory testing of rock anchors subjected to cyclic loading is thereafter presented. Finally, the paper presents a model predicting the capacity of a rock anchor segment, in terms of a ribbed bar, subjected to a cyclic load history. The research assumes a failure mode occurring in the interface between the rock anchor and the surrounding grout. The constitutive behavior of the bonding interface is investigated for anchors subjected to cyclic one-way tensile loads. The model utilizes the static bond capacity curve as a basis, defining the ultimate bond τbu and the slip s1 at τbu. A limited number of input parameters are required to apply the model. The model defines the bond-slip behavior with the belonging rock anchor capacity depending on the cyclic load level (τmax cy/τbu, the cyclic load ratio (R = τmin cy/τmax cy, and the number of load cycles (N. The constitutive model is intended to model short anchor lengths representing an incremental length of a complete rock anchor.

  9. Equating Subscores under the Nonequivalent Anchor Test (NEAT) Design

    Science.gov (United States)

    Puhan, Gautam; Liang, Longjuan

    2011-01-01

    The study examined two approaches for equating subscores. They are (1) equating subscores using internal common items as the anchor to conduct the equating, and (2) equating subscores using equated and scaled total scores as the anchor to conduct the equating. Since equated total scores are comparable across the new and old forms, they can be used…

  10. Career anchors and values from different career management perspectives

    Directory of Open Access Journals (Sweden)

    Rodrigo Cunha da Silva

    2016-06-01

    Full Text Available Purpose – To analyze the relationships between career anchors and young Generation Y professionals’ values, from the career concept perspective. Design/methodology/approach – Research concerning the proposed objective was carried out through quantitative research involving 189 Business Administration majors from a Catholic university in São Paulo, Brazil. We used two instruments to identify the career anchors and values of respondents: Schein (1990 and Schwartz (1994, respectively. We used statistical techniques to explore the relationships between career anchors and values. Findings – Among the results, mention should be made to the statistical relationships found between analyzed career anchors and values. It is also important to stress that, although the Lifestyle career anchor was predominantly present in the conglomerate division, this anchor was the predominant characteristic in the differentiation of the smaller group of respondents, the new career group. The General Management Career Anchor, which presents a lower incidence, is the predominant characteristic of the larger group, referring to organizational careers. As well as the Lifestyle career anchor, the Hedonism value was predominant among respondents. Originality/value – The need to consider the following was found: Generation Y presents generational characteristics that drive people management to propose work structures that offer activities to generate learning, pleasure, self-fulfillment and conciliation between work and personal life.

  11. Software Note: Using BILOG for Fixed-Anchor Item Calibration

    Science.gov (United States)

    DeMars, Christine E.; Jurich, Daniel P.

    2012-01-01

    The nonequivalent groups anchor test (NEAT) design is often used to scale item parameters from two different test forms. A subset of items, called the anchor items or common items, are administered as part of both test forms. These items are used to adjust the item calibrations for any differences in the ability distributions of the groups taking…

  12. Robust conductance of dumbbell molecular junctions with fullerene anchoring groups

    DEFF Research Database (Denmark)

    Markussen, Troels; Settnes, Mikkel; Thygesen, Kristian Sommer

    2011-01-01

    that a dumbbell construction with C60 molecules acting as anchors yields more well-defined conductances as compared to the widely used thiol anchoring groups. Here, we use density functional theory to investigate the electronic properties of this dumbbell construction. The conductance is found to be stable...

  13. Geological significance of stone anchors from Dwarka waters, Gujarat, India

    Digital Repository Service at National Institute of Oceanography (India)

    Iyer, S.D.; Vora, K.H.; Gaur, A.S.

    of the anchors in terms of the rock type and their availability are presented. Four anchors were sampled for petrological investigations of which one is basalt, one is sandstone, and two are limestone. The latter two rock types are abundant in the vicinity...

  14. Use of Jackknifing to Evaluate Effects of Anchor Item Selection on Equating with the Nonequivalent Groups with Anchor Test (NEAT) Design. Research Report. ETS RR-15-10

    Science.gov (United States)

    Lu, Ru; Haberman, Shelby; Guo, Hongwen; Liu, Jinghua

    2015-01-01

    In this study, we apply jackknifing to anchor items to evaluate the impact of anchor selection on equating stability. In an ideal world, the choice of anchor items should have little impact on equating results. When this ideal does not correspond to reality, selection of anchor items can strongly influence equating results. This influence does not…

  15. Biased calculations: Numeric anchors influence answers to math equations

    Directory of Open Access Journals (Sweden)

    Andrew R. Smith

    2011-02-01

    Full Text Available People must often perform calculations in order to produce a numeric estimate (e.g., a grocery-store shopper estimating the total price of his or her shopping cart contents. The current studies were designed to test whether estimates based on calculations are influenced by comparisons with irrelevant anchors. Previous research has demonstrated that estimates across a wide range of contexts assimilate toward anchors, but none has examined estimates based on calculations. In two studies, we had participants compare the answers to math problems with anchors. In both studies, participants' estimates assimilated toward the anchor values. This effect was moderated by time limit such that the anchoring effects were larger when the participants' ability to engage in calculations was limited by a restrictive time limit.

  16. Anchoring submersible ultrasonic receivers in river channels with stable substrate

    Science.gov (United States)

    Bettoli, Phillip William; Scholten, G.D.; Hubbs, D.

    2010-01-01

    We developed an anchoring system for submersible ultrasonic receivers (SURs) that we placed on the bottom of the riverine reaches of three main-stem reservoirs in the upper Tennessee River. Each anchor consisted of a steel tube (8.9 x 35.6 cm) welded vertically to a round plate of steel (5.1 x 40.6 cm). All seven SURs and their 57-kg anchors were successfully deployed and retrieved three times over 547 d by a dive team employing surface air-breathing equipment and a davit-equipped boat. All of the anchors and their SURs remained stationary over two consecutive winters on the hard-bottom, thalweg sites where they were deployed. The SUR and its anchor at the most downriver site experienced flows that exceeded 2,100 m(3)/s and mean water column velocities of about 0.9 m/s.

  17. Grapnel stone anchors from Saurashtra: Remnants of Indo-Arab trade on the Indian coast

    Digital Repository Service at National Institute of Oceanography (India)

    Gaur, A.S.; Sundaresh; Tripati, S.

    Stone anchors have been used as a primary source of information on ancient navigation by marine archaeologists since long. These anchors used by ancient mariners are often noticed underwater at various places across the world. Stone anchors are also...

  18. The Use of Two Anchors in Nonequivalent Groups with Anchor Test (NEAT) Equating. Research Report. ETS RR-10-23

    Science.gov (United States)

    Moses, Tim; Deng, Weiling; Zhang, Yu-Li

    2010-01-01

    In the equating literature, a recurring concern is that equating functions that utilize a single anchor to account for examinee groups' nonequivalence are biased when the groups are extremely different and/or when the anchor only weakly measures what the tests measure. Several proposals have been made to address this equating bias by incorporating…

  19. A magnetically actuated anchoring system for a wireless endoscopic capsule.

    Science.gov (United States)

    Zhou, Hao; Alici, Gursel; Munoz, Fredy

    2016-12-01

    In this study, we propose a new magnetically actuated anchoring system for wireless capsule endoscopes (WCE) by employing the principle of a switchable magnetic spring. A force model is derived to predict the magnetic force needed to support the interaction between the anchors and the intestinal lumen. The theoretical and experimental analysis conducted shows that the magnetic spring is capable of providing the force needed to activate the anchoring mechanism, which consists of four foldable legs. A prototype capsule with a size comparable with the size of a commercial WCE was designed, fabricated, and tested. The in-vitro tests with a real small intestine show that the proposed anchoring mechanism is able to raise the friction force between the anchoring legs and inner wall of the intestine by more than two times after its activation using an external magnetic field. Experimental results presented demonstrate that the proposed anchoring system, which has a low foot-print not taking up too much space on the capsule, can provide a reliable anchoring capability with the capsule inside the intestinal lumen.

  20. Quantifying Heuristic Bias: Anchoring, Availability, and Representativeness.

    Science.gov (United States)

    Richie, Megan; Josephson, S Andrew

    2018-01-01

    Construct: Authors examined whether a new vignette-based instrument could isolate and quantify heuristic bias. Heuristics are cognitive shortcuts that may introduce bias and contribute to error. There is no standardized instrument available to quantify heuristic bias in clinical decision making, limiting future study of educational interventions designed to improve calibration of medical decisions. This study presents validity data to support a vignette-based instrument quantifying bias due to the anchoring, availability, and representativeness heuristics. Participants completed questionnaires requiring assignment of probabilities to potential outcomes of medical and nonmedical scenarios. The instrument randomly presented scenarios in one of two versions: Version A, encouraging heuristic bias, and Version B, worded neutrally. The primary outcome was the difference in probability judgments for Version A versus Version B scenario options. Of 167 participants recruited, 139 enrolled. Participants assigned significantly higher mean probability values to Version A scenario options (M = 9.56, SD = 3.75) than Version B (M = 8.98, SD = 3.76), t(1801) = 3.27, p = .001. This result remained significant analyzing medical scenarios alone (Version A, M = 9.41, SD = 3.92; Version B, M = 8.86, SD = 4.09), t(1204) = 2.36, p = .02. Analyzing medical scenarios by heuristic revealed a significant difference between Version A and B for availability (Version A, M = 6.52, SD = 3.32; Version B, M = 5.52, SD = 3.05), t(404) = 3.04, p = .003, and representativeness (Version A, M = 11.45, SD = 3.12; Version B, M = 10.67, SD = 3.71), t(396) = 2.28, p = .02, but not anchoring. Stratifying by training level, students maintained a significant difference between Version A and B medical scenarios (Version A, M = 9.83, SD = 3.75; Version B, M = 9.00, SD = 3.98), t(465) = 2.29, p = .02, but not residents or attendings. Stratifying by heuristic and training level, availability maintained

  1. Anchored multi-DOF MEMS gyroscope having robust drive mode

    Science.gov (United States)

    Verma, Payal; Khonina, S. N.; Pavelyev, V. S.; Fomchenkov, S. A.; Uma, B. V.

    2016-12-01

    This paper presents the new architecture of 2-DOF (degree-of-freedom) drive mode and 1-DOF sense mode gyroscope with the concept of additional anchoring that retains all the advantages of the Dynamic Vibration Absorber (DVA) concept while being operated at high frequencies. These concepts allow reduction of the bandwidth by varying the coupling parameter during the design, thereby increasing the mechanical sensitivity. In the present design, the anchoring concept has been implemented by adding a central anchor for the sense mass. The steady state response and design concept have been devised using analytical modeling.

  2. Wave propagation in damage assessment of ground anchors

    Science.gov (United States)

    Zima, B.; Rucka, M.

    2015-07-01

    The inspection possibilities of ground anchors are limited to destructive test such as pull-out test. Guided wave propagation gives an opportunity to develop an inspection system dedicated to determine the condition of inspected element without violation of their integrity. In this paper the experimental study on wave propagation in laboratory models of ground anchors are presented. Experiments were conducted for different bonding lengths and different frequencies of excitation. Waves were generated by a piezoelectric actuator and the laser vibrometry technique was used to register velocity signals. For all tested anchors it was possible to identify the boundary between steel and concrete based on the registered reflections in wave propagation signals.

  3. Organizing signal transduction through A-kinase anchoring proteins (AKAPs).

    Science.gov (United States)

    Logue, Jeremy S; Scott, John D

    2010-11-01

    A fundamental role for protein-protein interactions in the organization of signal transduction pathways is evident. Anchoring, scaffolding and adapter proteins function to enhance the precision and directionality of these signaling events by bringing enzymes together. The cAMP signaling pathway is organized by A-kinase anchoring proteins. This family of proteins assembles enzyme complexes containing the cAMP-dependent protein kinase, phosphoprotein phosphatases, phosphodiesterases and other signaling effectors to optimize cellular responses to cAMP and other second messengers. Selected A-kinase anchoring protein signaling complexes are highlighted in this minireview. © 2010 The Authors Journal compilation © 2010 FEBS.

  4. Configuration of an inelastic flexible anchored cable

    Directory of Open Access Journals (Sweden)

    T. P. Dreyer

    1992-07-01

    Full Text Available Consider an inelastic, perfectly flexible cable with given external forces acting on the total length of the cable. The one end-point is fixed in the origin and the other end-point is anchored at a given point (a;b;c in space. The resulting configuration of the cable in space can be modelled by a system of non-linear differential equations. In this article it is shown that this continuous model of the cable can always be solved in terms of an integral. In the special case of a constant (i.e. independent of the position on the cable external force per unit length the solution is given explicitly in terms of three constants that describe the tension at the origin. These three constants are determined by the boundary values a, b and c at the other end-point, and must be calculated in general by a numerical procedure from the three resulting simultaneous non-linear equations. A few applications of this method are shown.

  5. Material Testing for Robotic Omnidirectional Anchor

    Science.gov (United States)

    Witkoe, Kevin S.

    2012-01-01

    To successfully explore near-Earth Asteroids the question of mobility emerges as the key issue for any robotic mission. When small bodies have extremely low escape velocities, traditional methods, such as wheels, would send the robot hurtling off of the asteroid's surface. To solve this problem, JPL has developed an omni-directional anchoring mechanism for use in microgravity that utilizes microspine technology. These microspines are placed in circular arrays with 16 independent carriages biasing the surface of the rock. The asperities in the surface allow the gripper to hold nearly 150N in all directions. While the gripper has been proven successful on consolidated rocks, it had yet to be tested on a variety of other surfaces that are suspected to separate the large boulders on an asteroid. Since asteroid surfaces vary widely, from friable rocks to lose ponds of regolith, the gripper was tested in a large variety of materials such as, bonded pumice, sand, gravel, and loose rocks. The forces are applied tangent, at 45 degrees, and normal to the surface of the material. The immediate results from this experiment will give insight into the gripper's effectiveness across the wide spectrum of materials found on asteroids.

  6. User's Guide for Tactical Thinking Behaviorally Anchored Rating Scales

    National Research Council Canada - National Science Library

    Phillips, Jennifer K; Ross, Karol G; Shadrick, Scott B

    2006-01-01

    .... In conjunction, measurement techniques must be developed to assess tactical thinking skills. This research product is a user's guide for the Tactical Thinking Behaviorally Anchored Rating Scales (T-BARS...

  7. New Mathematical Modelling of Stabilizing Pile with Prestressed Tieback Anchors

    Directory of Open Access Journals (Sweden)

    Cheng Huang

    2013-01-01

    Full Text Available This paper presents a novel mathematical modelling for analyzing stabilizing piles with prestressed tieback anchors. The new differential equations governing the mechanical response of the stabilizing pile are formulated and the boundary conditions considering the tie-back anchors are mathematically specified. Then, the system of differential equations is numerically solved by the high-accuracy Runge-Kutta finite difference method. A simple computer program has been written on the platform of MATLAB to run the procedure of the proposed algorithm. This approach is entirely different from the traditional finite element method used to design the anchored piles. The FEM is employed to verify the feasibility of the developed method. The comparative case study indicates that the proposed method has more higher modeling and computing efficiency than the FEM and can be an alternative method for designing the anchored pile used for slope stabilization.

  8. The anchoring bias reflects rational use of cognitive resources.

    Science.gov (United States)

    Lieder, Falk; Griffiths, Thomas L; M Huys, Quentin J; Goodman, Noah D

    2017-05-08

    Cognitive biases, such as the anchoring bias, pose a serious challenge to rational accounts of human cognition. We investigate whether rational theories can meet this challenge by taking into account the mind's bounded cognitive resources. We asked what reasoning under uncertainty would look like if people made rational use of their finite time and limited cognitive resources. To answer this question, we applied a mathematical theory of bounded rationality to the problem of numerical estimation. Our analysis led to a rational process model that can be interpreted in terms of anchoring-and-adjustment. This model provided a unifying explanation for ten anchoring phenomena including the differential effect of accuracy motivation on the bias towards provided versus self-generated anchors. Our results illustrate the potential of resource-rational analysis to provide formal theories that can unify a wide range of empirical results and reconcile the impressive capacities of the human mind with its apparently irrational cognitive biases.

  9. Anchored but not internalized: shape dependent endocytosis of nanodiamond

    Science.gov (United States)

    Zhang, Bokai; Feng, Xi; Yin, Hang; Ge, Zhenpeng; Wang, Yanhuan; Chu, Zhiqin; Raabova, Helena; Vavra, Jan; Cigler, Petr; Liu, Renbao; Wang, Yi; Li, Quan

    2017-04-01

    Nanoparticle-cell interactions begin with the cellular uptake of the nanoparticles, a process that eventually determines their cellular fate. In the present work, we show that the morphological features of nanodiamonds (NDs) affect both the anchoring and internalization stages of their endocytosis. While a prickly ND (with sharp edges/corners) has no trouble of anchoring onto the plasma membrane, it suffers from difficult internalization afterwards. In comparison, the internalization of a round ND (obtained by selective etching of the prickly ND) is not limited by its lower anchoring amount and presents a much higher endocytosis amount. Molecular dynamics simulation and continuum modelling results suggest that the observed difference in the anchoring of round and prickly NDs likely results from the reduced contact surface area with the cell membrane of the former, while the energy penalty associated with membrane curvature generation, which is lower for a round ND, may explain its higher probability of the subsequent internalization.

  10. Correlation of Persistence, Initiative and Career Anchors Categories of Students

    Directory of Open Access Journals (Sweden)

    I A Novikova

    2008-03-01

    Full Text Available The article is devoted to the analysis of the results of comparative empirical study of persistence, initiative and Career Anchors categories of the students on the basis of the systemic-functional approach.

  11. [Development and application of bone-anchored hearing aid].

    Science.gov (United States)

    Liu, Yupeng; Yang, Jun

    2013-01-01

    Bone-anchored hearing aid is a hearing assisting technology that raise the hearing level via bone conduct and is also the only implantable hearing assisting device working by bone conduct. Because of the superior performance and simple process of implantation, it brings gospel to the patients who are not fitting the air conducting hearing devices. This article is a review of bone-anchored hearing aid from 6 aspects, including history, principle, indication, consulting, surgery and complication.

  12. Peptide-Mediated Liposome Fusion: The Effect of Anchor Positioning

    Directory of Open Access Journals (Sweden)

    Niek S. A. Crone

    2018-01-01

    Full Text Available A minimal model system for membrane fusion, comprising two complementary peptides dubbed “E” and “K” joined to a cholesterol anchor via a polyethyleneglycol spacer, has previously been developed in our group. This system promotes the fusion of large unilamellar vesicles and facilitates liposome-cell fusion both in vitro and in vivo. Whilst several aspects of the system have previously been investigated to provide an insight as to how fusion is facilitated, anchor positioning has not yet been considered. In this study, the effects of placing the anchor at either the N-terminus or in the center of the peptide are investigated using a combination of circular dichroism spectroscopy, dynamic light scattering, and fluorescence assays. It was discovered that anchoring the “K” peptide in the center of the sequence had no effect on its structure, its ability to interact with membranes, or its ability to promote fusion, whereas anchoring the ‘E’ peptide in the middle of the sequence dramatically decreases fusion efficiency. We postulate that anchoring the ‘E’ peptide in the middle of the sequence disrupts its ability to form homodimers with peptides on the same membrane, leading to aggregation and content leakage.

  13. Two Approaches for Using Multiple Anchors in NEAT Equating: A Description and Demonstration

    Science.gov (United States)

    Moses, Tim; Deng, Weiling; Zhang, Yu-Li

    2011-01-01

    Nonequivalent groups with anchor test (NEAT) equating functions that use a single anchor can have accuracy problems when the groups are extremely different and/or when the anchor weakly correlates with the tests being equated. Proposals have been made to address these issues by incorporating more than one anchor into NEAT equating functions. These…

  14. Pyramidal anchor stone from Baga waters of Goa, west coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Tripati, S.

    . Pyramidal anchor stones have an apex hole which goes up to the round hole, however Goa anchor stone has no such perforation, but, instead has a rectangular cutting on the apex. The anchor stone is compared with Greek pyramidal anchor stones, and probably...

  15. On the Robustness of Anchoring Effects in WTP and WTA Experiments

    OpenAIRE

    Drew Fudenberg; David K Levine; Zacharias Maniadis

    2010-01-01

    We reexamine the effects of the anchoring manipulation of Ariely, Loewenstein, and Prelec (2003) on the evaluation of common market goods and find very weak anchoring effects. We perform the same manipulation on the evaluation of binary lotteries, and find no anchoring effects at all. This suggests limits on the robustness of anchoring effects. (JEL C91, D12, D44)

  16. Assessing tether anchor labeling and usability in pickup trucks.

    Science.gov (United States)

    Klinich, Kathleen D; Manary, Miriam A; Malik, Laura A; Flannagan, Carol A; Jermakian, Jessica S

    2018-04-03

    The objective of this study was to investigate vehicle factors associated with child restraint tether use and misuse in pickup trucks and evaluate 4 labeling interventions designed to educate consumers on proper tether use. Volunteer testing was performed with 24 subjects and 4 different pickup trucks. Each subject performed 8 child restraint installations among the 4 pickups using 2 forward-facing restraints: a Britax Marathon G4.1 and an Evenflo Triumph. Vehicles were selected to represent 4 different implementations of tether anchors among pickups: plastic loop routers (Chevrolet Silverado), webbing routers (Ram), back wall anchors (Nissan Frontier), and webbing routers plus metal anchors (Toyota Tundra). Interventions included a diagram label, Quick Response (QR) Code linked to video instruction, coordinating text label, and contrasting text tag. Subjects used the child restraint tether in 93% of trials. However, tether use was completely correct in only 9% of trials. An installation was considered functional if the subject attached the tether to a tether anchor and had a tight installation (ignoring routing and head restraint position); 28% of subjects achieved a functional installation. The most common installation error was attaching the tether hook to the anchor/router directly behind the child restraint (near the top of the seatback) rather than placing the tether through the router and attaching it to the anchor in the adjacent seating position. The Nissan Frontier, with the anchor located on the back wall of the cab, had the highest rate of correct installations but also had the highest rate of attaching the tether to components other than the tether anchor (seat adjustor, child restraint storage hook, around head restraint). None of the labeling interventions had a significant effect on correct installation; not a single subject scanned the QR Code to access the video instruction. Subjects with the most successful installations spent extensive time

  17. Vesicle Fusion Mediated by Solanesol-Anchored DNA.

    Science.gov (United States)

    Flavier, Kristina M; Boxer, Steven G

    2017-09-19

    Fusion between two lipid bilayers is one of the central processes in cell biology, playing a key role in endocytosis, exocytosis, and vesicle transport. We have previously developed a model system that uses the hybridization of complementary DNA strands to model the formation of the SNARE four-helix bundle that mediates synaptic vesicle fusion and used it to study vesicle fusion to a tethered lipid bilayer. Using single vesicle assays, 70% of observed fusion events in the DNA-lipid system are arrested at the hemifusion stage, whereas only 5% eventually go to full fusion. This may be because the diglycerol ether that anchors the DNA in the membrane spans only half the bilayer: upon hemifusion and mixing of the outer leaflets, the DNA-lipid is free to diffuse into the target membrane and away from the vesicle. Here, we test the hypothesis that the length of the membrane anchor may impact the outcome by comparing single leaflet-spanning DNA-lipid mediated vesicle fusion with fusion mediated by DNA anchored by solanesol, a C45 isoprenoid of sufficient length to span the bilayer. When the solanesol anchor was present on the incoming vesicles, target membrane, or both, ∼2-3 times as much full fusion was observed as in the DNA-lipid mediated system, as measured by lipid mixing or content transfer. These results indicate that a transmembrane anchor increases the efficiency of full fusion. Copyright © 2017 Biophysical Society. Published by Elsevier Inc. All rights reserved.

  18. How curved membranes recruit amphipathic helices and protein anchoring motifs.

    Science.gov (United States)

    Hatzakis, Nikos S; Bhatia, Vikram K; Larsen, Jannik; Madsen, Kenneth L; Bolinger, Pierre-Yves; Kunding, Andreas H; Castillo, John; Gether, Ulrik; Hedegård, Per; Stamou, Dimitrios

    2009-11-01

    Lipids and several specialized proteins are thought to be able to sense the curvature of membranes (MC). Here we used quantitative fluorescence microscopy to measure curvature-selective binding of amphipathic motifs on single liposomes 50-700 nm in diameter. Our results revealed that sensing is predominantly mediated by a higher density of binding sites on curved membranes instead of higher affinity. We proposed a model based on curvature-induced defects in lipid packing that related these findings to lipid sorting and accurately predicted the existence of a new ubiquitous class of curvature sensors: membrane-anchored proteins. The fact that unrelated structural motifs such as alpha-helices and alkyl chains sense MC led us to propose that MC sensing is a generic property of curved membranes rather than a property of the anchoring molecules. We therefore anticipate that MC will promote the redistribution of proteins that are anchored in membranes through other types of hydrophobic moieties.

  19. Anchoring effect on first passage process in Taiwan financial market

    Science.gov (United States)

    Liu, Hsing; Liao, Chi-Yo; Ko, Jing-Yuan; Lih, Jiann-Shing

    2017-07-01

    Empirical analysis of the price fluctuations of financial markets has received extensive attention because a substantial amount of financial market data has been collected and because of advances in data-mining techniques. Price fluctuation trends can help investors to make informed trading decisions, but such decisions may also be affected by a psychological factors-the anchoring effect. This study explores the intraday price time series of Taiwan futures, and applies diffusion model and quantitative methods to analyze the relationship between the anchoring effect and price fluctuations during first passage process. Our results indicate that power-law scaling and anomalous diffusion for stock price fluctuations are related to the anchoring effect. Moreover, microscopic price fluctuations before switching point in first passage process correspond with long-term price fluctuations of Taiwan's stock market. We find that microscopic trends could provide useful information for understanding macroscopic trends in stock markets.

  20. A reusable suture anchor for arthroscopy psychomotor skills training.

    Science.gov (United States)

    Tillett, Edward D; Rogers, Rainie; Nyland, John

    2003-03-01

    For residents to adequately develop the early arthroscopy psychomotor skills required to better learn how to manage the improvisational situations they will encounter during actual patient cases, they need to experience sufficient practice repetitions within a contextually relevant environment. Unfortunately, the cost of suture anchors can be a practice repetition-limiting factor in learning arthroscopic knot-tying techniques. We describe a technique for creating inexpensive reusable suture anchors and provide an example of their application to repair the anterior glenoid labrum during an arthroscopy psychomotor skills laboratory training session.

  1. Fullerene-based Anchoring Groups for Molecular Electronics

    DEFF Research Database (Denmark)

    Martin, Christian A.; Ding, Dapeng; Sørensen, Jakob Kryger

    2008-01-01

    We present results on a new fullerene-based anchoring group for molecular electronics. Using lithographic mechanically controllable break junctions in vacuum we have determined the conductance and stability of single-molecule junctions of 1,4-bis(fullero[c]pyrrolidin-1-yl)benzene. The compound can...... be self-assembled from solution and has a low-bias conductance of 3 × 10-4 G0. Compared to 1,4-benzenedithiol the fullerene-anchored molecule exhibits a considerably lower conductance spread. In addition, the signature of the new compound in histograms is more significant than that of 1,4-benzenediamine...

  2. Experience-based, body-anchored qualitative research interviewing

    DEFF Research Database (Denmark)

    Stelter, Reinhard

    2010-01-01

    -anchored interviewing, and second, by an interview guide that explores a research participant's personal experience with mindfulness meditation. An excerpt from an interview is discussed to illustrate the advantages of this interview form, namely its value as a methodological instrument for qualitative research......Two theoretical constructs that lay the foundation for experience-based, body-anchored interviewing are presented: the first-person perspective and the concept of meaning. These theoretical concepts are concretized, first, by means of a methodological framework for experience-based, body...

  3. The importance of anchor text for ad hoc search revisited

    NARCIS (Netherlands)

    Koolen, M.; Kamps, J.; Chen, H.-H.; Efthimiadis, E.N.; Savoy, J.; Crestani, F.; Marchand-Maillet, S.

    2010-01-01

    It is generally believed that propagated anchor text is very important for effective Web search as offered by the commercial search engines. "Google Bombs" are a notable illustration of this. However, many years of TREC Web retrieval research failed to establish the effectiveness of link evidence

  4. Comparative study of retentive anchor systems for overdentures.

    Science.gov (United States)

    Svetlize, Carlos A; Bodereau, Enrique Fernández

    2004-06-01

    This study aimed to evaluate the retention on two or four implants of eight resilient and nonresilient retentive anchors used in overdentures. Eight groups of retentive anchors were used: Dyna and Shiner (magnets); Dalla Bona and O-Ring (balls); Ceka Revax and Zaag attachments (studs); the cast bar (Dolder type) system with plastic clips; and the milled bars system. These specimens with their respective overdentures were prepared on two similar acrylic resin models with four implants (3.75 x 13 mm). Ten tensile strength tests (Instron) were performed on each group at a speed of 3 mm per minute. The statistical analysis (one-way analysis of variance, Tukey's HSD test) was considered significant. The pull force values ranged between 0.400 and 3.800 daN (International System of Units). There was a significant difference in retention in favor of the milled bars in comparison with the Ceka Revax, Hader bars, Zaag attachments, O-Ring, and Dyna groups, and a marginally significant difference compared with the Dalla Bona group. There was a highly significant difference with the Shiner magnets. The milled bar system was the most retentive anchor, with the Dalla Bona, Ceka Revax, Hader Bar, Zaag attachment, and O-Ring groups being the second most retentive. The least retentive groups were the Shiner and Dyna magnets. Proper abutment placement in the mandible and the correct selection of the retentive anchor will improve overdenture retention.

  5. Testing the specifications of parametric models using anchoring vignettes

    NARCIS (Netherlands)

    van Soest, A.H.O.; Vonkova, H.

    Comparing assessments on a subjective scale across countries or socio-economic groups is often hampered by differences in response scales across groups. Anchoring vignettes help to correct for such differences, either in parametric models (the compound hierarchical ordered probit (CHOPIT) model and

  6. Local ecological knowledge (LEK) on fish behavior around anchored FADs

    NARCIS (Netherlands)

    Macusi, Edison D.; Abreo, Neil A.S.; Babaran, Ricardo P.

    2017-01-01

    The Fishing Industry in the Philippines plays an important role in the food and employment need of Filipino fishers. By using anchored Fish Aggregating Devices (FADs or payao), the Philippine tuna fisheries was transformed into a million-dollar industry. Minimal studies on exploitation rates and

  7. Isolation by the 5 anchored PCR technique and characterization of ...

    Indian Academy of Sciences (India)

    Isolation by the 5 anchored PCR technique and characterization of eighteen microsatellite loci in horseshoe crab (Tachypleus gigas). LIEW PUI LING, ABU BAKAR ADIBAH, SOON GUAN TAN. ∗. , ANNIE CHRISTIANUS and QAMARUZ ZAMAN FARIDAH. Universiti Putra Malaysia, UPM Serdang, Selangor, 43400, Malaysia.

  8. The role of personal protective factors in anchoring psychological ...

    African Journals Online (AJOL)

    Erna Kinsey

    In this article I report on a study that focused on the concept of resilience, in order to determine the nature of personal attributes in adoles cents with ... nine key personal attributes which anchored resilience and promoted self actualisation, despite obstacle ridden circumstances. Introduction ... and result in vulnerability.

  9. The relation between career anchors, emotional intelligence and ...

    African Journals Online (AJOL)

    satisfaction. Prof. M. Coetzee and Prof. D. Schreuder are in the Department of Industrial and Organisational Psychology,. University of South Africa. E-mail: ... People's career anchors influence their career choices, life satisfaction, and job and ... employees' subjective work experiences, and job and career satisfaction.

  10. Ten Anchor Points for Teaching Principles of Marketing

    Science.gov (United States)

    Tomkovick, Chuck

    2004-01-01

    Effective marketing instructors commonly share a love for their students, an affinity for the subject matter, and a devotion to continuous quality improvement. The purpose of this article is to highlight 10 anchor points for teaching Principles of Marketing, which are designed to better engage students in the learning process. These anchor…

  11. Stable Pt clusters anchored to monovacancies on graphene sheets

    Energy Technology Data Exchange (ETDEWEB)

    Medasani, Bharat K.; Liu, Jun; Sushko, Maria L.

    2017-10-09

    Abstract

    anchor'>

  12. Analytical Model for Hook Anchor Pull-Out

    DEFF Research Database (Denmark)

    Brincker, Rune; Ulfkjær, Jens Peder; Adamsen, Peter

    1995-01-01

    A simple analytical model for the pull-out of a hook anchor is presented. The model is based on a simplified version of the fictitious crack model. It is assumed that the fracture process is the pull-off of a cone shaped concrete part, simplifying the problem by assuming pure rigid body motions...

  13. Analytical Model for Hook Anchor Pull-out

    DEFF Research Database (Denmark)

    Brincker, Rune; Ulfkjær, J. P.; Adamsen, P.

    A simple analytical model for the pull-out of a hook anchor is presented. The model is based on a simplified version of the fictitious crack model. It is assumed that the fracture process is the pull-off of a cone shaped concrete part, simplifying the problem by assuming pure rigid body motions...

  14. Culturally-Anchored Values and University Education Experience Perception

    Science.gov (United States)

    Mitsis, Ann; Foley, Patrick

    2009-01-01

    Purpose: The purpose of this paper is to examine whether business students' gender, age and culturally-anchored values affect their perceptions of their university course experience. Design/methodology/approach: Culturally diverse business students (n 1/4 548) studying at an Australian university were surveyed using previously established scales.…

  15. Empirical evidence for resource-rational anchoring and adjustment.

    Science.gov (United States)

    Lieder, Falk; Griffiths, Thomas L; M Huys, Quentin J; Goodman, Noah D

    2017-05-08

    People's estimates of numerical quantities are systematically biased towards their initial guess. This anchoring bias is usually interpreted as sign of human irrationality, but it has recently been suggested that the anchoring bias instead results from people's rational use of their finite time and limited cognitive resources. If this were true, then adjustment should decrease with the relative cost of time. To test this hypothesis, we designed a new numerical estimation paradigm that controls people's knowledge and varies the cost of time and error independently while allowing people to invest as much or as little time and effort into refining their estimate as they wish. Two experiments confirmed the prediction that adjustment decreases with time cost but increases with error cost regardless of whether the anchor was self-generated or provided. These results support the hypothesis that people rationally adapt their number of adjustments to achieve a near-optimal speed-accuracy tradeoff. This suggests that the anchoring bias might be a signature of the rational use of finite time and limited cognitive resources rather than a sign of human irrationality.

  16. Anchoring return: the role of the Solutions Strategy

    Directory of Open Access Journals (Sweden)

    Pierfrancesco Maria Natta

    2014-05-01

    Full Text Available Providing a minimum standard of living and livelihood opportunities to help anchor those who have returned is critical for the future stability and security of Afghanistan. This is one of the three main objectives of the 2012 Solutions Strategy for Afghan Refugees.

  17. A Proteomics Investigation of Anchored PKA-RI Signaling

    NARCIS (Netherlands)

    Kovanich, D.

    2013-01-01

    Compartmentalization of kinases and phosphatases plays an important role in the specificity of second messenger mediated signaling events. Localization of the cAMP-dependent protein kinase is mediated by interaction of its regulatory subunit (PKA-R) with the versatile family of A-kinase anchoring

  18. Fullerene-based Anchoring Groups for Molecular Electronics

    DEFF Research Database (Denmark)

    Martin, Christian A.; Ding, Dapeng; Sørensen, Jakob Kryger

    2008-01-01

    We present results on a new fullerene-based anchoring group for molecular electronics. Using lithographic mechanically controllable break junctions in vacuum we have determined the conductance and stability of single-molecule junctions of 1,4-bis(fullero[c]pyrrolidin-1-yl)benzene. The compound can...

  19. Modified Anchor Shaped Post Core Design for Primary Anterior Teeth

    Directory of Open Access Journals (Sweden)

    R. Rajesh

    2014-01-01

    Full Text Available Restoring severely damaged primary anterior teeth is challenging to pedodontist. Many materials are tried as a post core but each one of them has its own drawbacks. This a case report describing a technique to restore severely damaged primary anterior teeth with a modified anchor shaped post. This technique is not only simple and inexpensive but also produces better retention.

  20. Poor Anchoring Limits Dyslexics' Perceptual, Memory, and Reading Skills

    Science.gov (United States)

    Oganian, Yulia; Ahissar, Merav

    2012-01-01

    The basic deficits underlying the severe and persistent reading difficulties in dyslexia are still highly debated. One of the major topics of debate is whether these deficits are language specific, or affect both verbal and non-verbal stimuli. Recently, Ahissar and colleagues proposed the "anchoring-deficit hypothesis" (Ahissar, Lubin,…

  1. Stone anchors from the Okhamandal region, Gujarat Coast, India

    Digital Repository Service at National Institute of Oceanography (India)

    Sundaresh; Gaur, A.S.; Gudigar, P.; Tripati, S.; Vora, K.H.; Bandodkar, S.N.

    period particularly on south-western coast of the island while stone anchors were noticed on the eastern coast of the island where medieval period remains can be noticed in the form of pottery, cannons and a few stone structures. Similar type of stone...

  2. Bone-anchored hearing aids in unilateral inner ear deafness.

    NARCIS (Netherlands)

    Bosman, A.J.; Hol, M.K.S.; Snik, A.F.M.; Mylanus, E.A.M.; Cremers, C.W.R.J.

    2003-01-01

    In nine patients with unilateral deafness and normal hearing in the contralateral ear, measurements of sound localization and speech perception were obtained before intervention, with a conventional contralateral routing of sound (CROS) hearing aid and later with a bone-anchored hearing aid (BAHA)

  3. Candidacy for the bone-anchored hearing aid.

    NARCIS (Netherlands)

    Snik, A.F.M.; Bosman, A.J.; Mylanus, E.A.M.; Cremers, C.W.R.J.

    2004-01-01

    The BAHA (bone-anchored hearing aid) is a bone conduction hearing aid with percutaneous transmission of sound vibrations to the skull. The device has been thoroughly evaluated by various implant groups. These studies showed that, in audiological terms, the BAHA is superior to conventional bone

  4. The point-defect of carbon nanotubes anchoring Au nanoparticles

    DEFF Research Database (Denmark)

    Lv, Y. A.; Cui, Y. H.; Li, X. N.

    2010-01-01

    between Au clusters and CNTs by means of density functional theory calculations. Both experimental and theoretical studies show that point defects are the anchoring sites of Au nanoparticles. The mechanisms of enhanced bond between Au and CNTs via the point defects are explained by the analysis of density...

  5. Career Anchors of United States Air Force Information Systems Workers: A Turnover Predictor

    National Research Council Canada - National Science Library

    Wynne, Lee

    2002-01-01

    ...) and the work of Schein (1987) to measure the career anchors, job satisfaction, and turnover intention of AF IS workers to determine if those whose job type and career anchor match report higher satisfaction and lower turnover...

  6. Study on effective anchorage length of anchor cable based on Gauss's function

    Science.gov (United States)

    Ren, Feng; WuShuai; Liu, Yan; Liu, Jun-yan

    2017-11-01

    In the current relevant codes and technical standards, the design of anchor cables (bars) is based on the assumption that the shear stress is distributed uniformly along the anchor segment. However, according to this assumption, the super-deep pit need a large uplift bearing capacity, which will lead to the long anchor segment and has great hidden danger in the actual engineering design. Therefore, this paper, based on the previous derived shear stress function between τ and the anchor length, we get a research suitable model-Gauss curve distribution model through the analysis of saturated clay drawing data, and strata anchor shear stress distribution is more suitable for the Gauss function model in saturated clay; at the same time, through the FLAC numerical simulation of Jinan Government Affairs Center project, we obtained the optimal anchor effective anchor length is about 10~12m, the foundation pit anchor is optimized.

  7. Historical period stone anchors from Vijaydurg on the west coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Tripati, S.; Gaur, A.S.; Sundaresh; Bandodkar, S.N.

    Stone anchors are the primary antiquites in marine archaeological studies. Evidences of their evolution are noticed in India since 2500 B.C. A number of stone anchors have been recovered during the recent marine archaeological explorations at Dwarka...

  8. Retractable Robotic Anchor for Hard Rock and Granular Soils, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — ProtoInnovations, LLC, is developing an innovative retractable robotic anchor that works in hard rock and granular soils permitting anchoring and subsequent...

  9. Steel shear strength of anchors with stand-off base plates.

    Science.gov (United States)

    2013-09-01

    Sign and signal structures are often connected to concrete foundations through a stand-off annular base plate with a double-nut anchor bolt connection, which leaves exposed anchor bolt lengths below leveling nuts used in these connections. Cantilever...

  10. Biomechanical Comparison of a First- and a Second-Generation All-Soft Suture Glenoid Anchor

    Science.gov (United States)

    Erickson, John; Chiarappa, Frank; Haskel, Jonathan; Rice, Justin; Hyatt, Adam; Monica, James; Dhawan, Aman

    2017-01-01

    Background: All–soft tissue suture anchors provide advantages of decreased removal of bone and decreased glenoid volume occupied compared with traditional tap or screw-in suture anchors. Previous published data have led to biomechanical concerns with the use of first-generation all-soft suture anchors. Purpose/Hypothesis: The purpose of this study was to evaluate the load to 2-mm displacement and ultimate load to failure of a second-generation all-soft suture anchor, compared with a first-generation anchor and a traditional PEEK (polyether ether ketone) anchor. The null hypothesis was that the newer second-generation anchor will demonstrate no difference in loads to 2-mm displacement after cycling compared with first-generation all-soft suture anchors. Study Design: Controlled laboratory study. Methods: Twenty human cadaveric glenoids were utilized to create 97 total suture anchor sites, and 1 of 3 anchors were randomized and placed into each site: (1) first-generation all-soft suture anchor (Juggerknot; Biomet), (2) second-generation all-soft suture anchor (Suturefix; Smith & Nephew), and (3) a control PEEK anchor (Bioraptor; Smith & Nephew). After initial cyclic loading, load to 2 mm of displacement and ultimate load to failure were measured for each anchor. Results: After cyclic loading, the load to 2-mm displacement was significantly less in first-generation anchors compared with controls (P .05). Conclusion: The newer generation all-soft suture anchors with a theoretically more rigid construct and deployment configuration demonstrate biomechanical characteristics (specifically, with load to 2-mm displacement after cyclic loading) that are improved over first-generation all-soft suture anchors and similar to a traditional solid tap-in anchor. The configuration of these newer generation all-soft suture anchors appears to mitigate the biomechanical concerns of decreased load to failure with first-generation all–soft tissue suture anchors. Clinical Relevance

  11. Do budget balance rules anchor budget balance expectations? -- Some international evidence

    OpenAIRE

    Rülke, Jan-Christoph; Frenkel, Michael; Lis, Eliza

    2013-01-01

    This is the first study that analyzes whether budget balance expectations are anchored and whether budget balance rules effectively anchor expectations. To this end, we use a unique data set which covers budget balance expectations in 17 countries that implemented a budget balance rules. While our results are mixed concerning the general impact of budget balance rules on anchoring expectations, we do find that specific features of budget balance rules are important to successfully anchor budg...

  12. Perception of the Raison d'Etre in Anchored Instruction: An Ecological Psychology Perspective.

    Science.gov (United States)

    Young, Michael F.; Barab, Sasha A.

    1999-01-01

    Anchored instruction calls for the establishment of a macrocontext to "anchor" instruction within a realistic situation. Evidence is provided that video anchors encourage students to adopt certain contrived goals over their more naturalistic goals. Suggests that goals that enable the problem solver to detect the "raison d'etre"…

  13. Observed Score Equating Using Discrete and Passage-Based Anchor Items

    Science.gov (United States)

    Zu, Jiyun; Liu, Jinghua

    2010-01-01

    Equating of tests composed of both discrete and passage-based multiple choice items using the nonequivalent groups with anchor test design is popular in practice. In this study, we compared the effect of discrete and passage-based anchor items on observed score equating via simulation. Results suggested that an anchor with a larger proportion of…

  14. Management of subluxated capsular bag-fixated intraocular lenses using a capsular anchor

    NARCIS (Netherlands)

    Ton, Yokrat; Naftali, Modi; Lapid Gortzak, Ruth; Assia, Ehud I.

    2016-01-01

    We describe the use of the capsular anchor (AssiAnchor) to manage a subluxated intraocular lens (IOL) in the capsular bag. The anchor comprises 2 prongs that hold the anterior lens capsule and a central rod that is sutured to the scleral wall, enabling centration of the IOL-capsular bag complex. Six

  15. Biomimetic Mussel Adhesive Inspired Clickable Anchors Applied to the Functionalization of Fe3O4 Nanoparticles

    NARCIS (Netherlands)

    Goldmann, Anja S.; Schoedel, Christine; Walther, Andreas; Yuan, Jiayin; Loos, Katja; Mueller, Axel H. E.; Müller, Axel H.E.

    2010-01-01

    The functionalization of magnetite (Fe3O4) nanoparticles with dopamine-derived clickable biomimetic anchors is reported. Herein, an alkyne-modified catechol-derivative is employed as the anchor, as i) the catechol-functional anchor groups possess irreversible covalent binding affinity to Fe3O4

  16. Exploring microblog activity for the prediction of hyperlink anchors in television broadcasts

    NARCIS (Netherlands)

    Vliegendhart, R.; Liem, C.C.S.; Larson, M.A.

    2015-01-01

    In this paper, we present a social media based approach to finding anchors in video archives. We use social activity on Twitter to find topics on which people have questions about in order to select suitable anchors. The experiments were carried out on the MediaEval Search and Anchoring in Video

  17. Optimal suture anchor direction in arthroscopic lateral ankle ligament repair.

    Science.gov (United States)

    Yoshimura, Ichiro; Hagio, Tomonobu; Noda, Masahiro; Kanazawa, Kazuki; Minokawa, So; Yamamoto, Takuaki

    2017-05-26

    In this study, the distance between the insertion point of the suture anchors and posterior surface of the fibula during arthroscopic lateral ankle ligament repair was investigated on computed tomography (CT) images. The hypothesis of this study was that there is an optimal insertional direction of the suture anchor to avoid anchor-related complications. One hundred eleven ankles of 98 patients who had undergone three-dimensional CT scans for foot or ankle disorders without deformity of the fibula were assessed (59 males, 52 females; median age 25.5 years; age range 12-78 years). The shortest distance from the insertion point of the suture anchor to the deepest point of the fossa/top of the convex aspect of the fibula was measured on the axial plane, tilting from the longitudinal axis of the fibula at 90°, 75°, 60°, and 45°. The distance from the insertion point of the suture anchor to the posterior surface of the fibula was also measured in a direction parallel to the sagittal plane of the lateral surface of the talus on the axial plane, tilting from the longitudinal axis of the fibula at 90°, 75°, 60°, and 45°. The posterior fossa was observed in all cases on the 90° and 75° images. The distance from the insertion point to the posterior surface of the fibula in the parallel direction was 15.0 ± 3.4 mm at 90°, 17.5 ± 3.2 mm at 75°, 21.7 ± 3.3 mm at 60°, and 25.7 ± 3.6 mm at 45°. The posterior points in the parallel direction were located on the posterior fossa in 36.0% of cases at 90°, in 12.6% at 75°, and in 0.0% at 60° and 45°. The suture anchor should be directed from anterior to posterior at an angle of <45° to the longitudinal axis of the fibula, parallel to the lateral surface of the talus, to avoid passing through the fibula. Cohort study, Level III.

  18. Constrained Active Learning for Anchor Link Prediction Across Multiple Heterogeneous Social Networks.

    Science.gov (United States)

    Zhu, Junxing; Zhang, Jiawei; Wu, Quanyuan; Jia, Yan; Zhou, Bin; Wei, Xiaokai; Yu, Philip S

    2017-08-03

    Nowadays, people are usually involved in multiple heterogeneous social networks simultaneously. Discovering the anchor links between the accounts owned by the same users across different social networks is crucial for many important inter-network applications, e.g., cross-network link transfer and cross-network recommendation. Many different supervised models have been proposed to predict anchor links so far, but they are effective only when the labeled anchor links are abundant. However, in real scenarios, such a requirement can hardly be met and most anchor links are unlabeled, since manually labeling the inter-network anchor links is quite costly and tedious. To overcome such a problem and utilize the numerous unlabeled anchor links in model building, in this paper, we introduce the active learning based anchor link prediction problem. Different from the traditional active learning problems, due to the one-to-one constraint on anchor links, if an unlabeled anchor link a = ( u , v ) is identified as positive (i.e., existing), all the other unlabeled anchor links incident to account u or account v will be negative (i.e., non-existing) automatically. Viewed in such a perspective, asking for the labels of potential positive anchor links in the unlabeled set will be rewarding in the active anchor link prediction problem. Various novel anchor link information gain measures are defined in this paper, based on which several constraint active anchor link prediction methods are introduced. Extensive experiments have been done on real-world social network datasets to compare the performance of these methods with state-of-art anchor link prediction methods. The experimental results show that the proposed Mean-entropy-based Constrained Active Learning (MC) method can outperform other methods with significant advantages.

  19. Constrained Active Learning for Anchor Link Prediction Across Multiple Heterogeneous Social Networks

    Directory of Open Access Journals (Sweden)

    Junxing Zhu

    2017-08-01

    Full Text Available Nowadays, people are usually involved in multiple heterogeneous social networks simultaneously. Discovering the anchor links between the accounts owned by the same users across different social networks is crucial for many important inter-network applications, e.g., cross-network link transfer and cross-network recommendation. Many different supervised models have been proposed to predict anchor links so far, but they are effective only when the labeled anchor links are abundant. However, in real scenarios, such a requirement can hardly be met and most anchor links are unlabeled, since manually labeling the inter-network anchor links is quite costly and tedious. To overcome such a problem and utilize the numerous unlabeled anchor links in model building, in this paper, we introduce the active learning based anchor link prediction problem. Different from the traditional active learning problems, due to the one-to-one constraint on anchor links, if an unlabeled anchor link a = ( u , v is identified as positive (i.e., existing, all the other unlabeled anchor links incident to account u or account v will be negative (i.e., non-existing automatically. Viewed in such a perspective, asking for the labels of potential positive anchor links in the unlabeled set will be rewarding in the active anchor link prediction problem. Various novel anchor link information gain measures are defined in this paper, based on which several constraint active anchor link prediction methods are introduced. Extensive experiments have been done on real-world social network datasets to compare the performance of these methods with state-of-art anchor link prediction methods. The experimental results show that the proposed Mean-entropy-based Constrained Active Learning (MC method can outperform other methods with significant advantages.

  20. The biggest stone anchors (Indo-Arab type) from Mithi Virdi, Bhavnagar, west coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Gaur, A.S.; Sundaresh; Kumar, B.

    ) 4367 3871 4041 4399 1323 Note: Weight of 1 Cubic m stone is 2600 kgs and then 10% correction applied to first 4 anchors. DISCUSSION Marine archaeological explorations along the Indian coast during the last two decades brought to light a large number...-called Indo-Arab type anchors have been noticed. The state of the anchors suggests that they have not been used and one of the anchors is actually noticed on the anchor. It has a rough surface and sharp edges. The sections on both ends are rectangular...

  1. Cyclic loading biomechanical analysis of the pullout strengths of rotator cuff and glenoid anchors: 2013 update.

    Science.gov (United States)

    Barber, F Alan; Herbert, Morley A

    2013-05-01

    The purpose of this study was to evaluate the biomechanical and design characteristics of newer suture anchors under cyclic loading. Suture anchors were tested in fresh porcine cortical and cancellous bone by cyclic loading (10 to 100 N for 200 cycles) followed by destructive testing parallel to the insertion axis at 12.5 mm per second. End points included ultimate failure load, displacement at 100 and 200 cycles, failure mode, and stiffness. Anchors tested included ReelX (Stryker Endoscopy, San Jose, CA); Footprint Ultra PK (4.5 and 5.5 mm) (Smith & Nephew, Andover, MA); TwinFix (4.5, 5.5, and 6.5 mm made from polyether ether ketone [PEEK], hydroxyapatite [HA], and titanium [Ti]) (Smith & Nephew Endoscopy, Andover, MA); Morphix (2.5 and 5.5 mm) (MedShape Solutions, Atlanta, GA); CrossFT BC (ConMed-Linvatec, Largo, FL); JuggerKnot (1.5 and 2.8 mm) (Biomet Sports Medicine, Warsaw, IN); Healicoil (Smith & Nephew Endoscopy, Andover, MA); Quattro (X, Link, and GL) (Cayenne Medical, Scottsdale, AZ); Healix (Biocryl Rapide [BR], PEEK, and Ti) (DePuy Mitek, Raynham, MA); Twin Loop (3.5 mm, PEEK) (Stryker Endoscopy, San Jose, CA); PressFT (2.1 and 2.6 mm) (ConMed Linvatec, Largo FL); Y-Knot (ConMed Linvatec, Largo FL); Gryphon (BR and PEEK) (DePuy Mitek, Raynham, MA); and Iconix (1, 2, and 3) (Stryker Endoscopy, San Jose, CA). Rotator cuff anchors showed greater failure loads than did glenoid anchors in metaphyseal bone (rotator cuff anchors 448 N v glenoid anchors 296 N) (P = .001) and cancellous bone (rotator cuff anchors 435 N v glenoid anchors 225 N) (P strengths than did glenoid anchors, regardless of bone type. TwinFix anchors showed more cyclic displacement than did other rotator cuff anchors (except the ReelX and Morphix anchors) and the glenoid anchors tested. The failure mode was dependent on the specific anchor. Suture anchor constructs tested showed that failure load is dependent on anchor type (rotator cuff anchor or glenoid anchor) but not on anchor location

  2. Anomalous temperature-dependent anchoring in liquid crystals mediated by thermodynamic smectic wetting sheets

    Science.gov (United States)

    Aya, Satoshi; Araoka, Fumito

    2017-11-01

    We present an unusual temperature dependence of polar anchoring torque in a nematic liquid crystal contacting with a perfluoropolymer surface. Whereas the anchoring torque is conventionally expected to increase with decreasing temperature, we show that the polar anchoring torque in the present system decreases with decreasing temperature. This causes an orientational transition from planar to vertical during cooling. We explain the origin of this phenomenon as the result of thermodynamic growth and spreading of surface-localized smectic wetting sheets. We clearly show that the coverage of these wetting sheets on the surface creates a vertical state that violates the initial planar anchoring in the bulk, thereby reducing the effective polar anchoring torque.

  3. Optimization Analysis Model of Self-Anchored Suspension Bridge

    Directory of Open Access Journals (Sweden)

    Pengzhen Lu

    2014-01-01

    Full Text Available The hangers of self-anchored suspension bridge need to be tensioned suitably during construction. In view of this point, a simplified optimization calculation method of cable force for self-anchored suspension bridge has been developed based on optimization theories, such as minimum bending energy method, and internal force balanced method, influence matrix method. Meanwhile, combined with the weak coherence of main cable and the adjacently interaction of hanger forces, a simplified analysis method is developed using MATLAB, which is then compared with the optimization method that consider the main cable's geometric nonlinearity with software ANSYS in an actual example bridge calculation. This contrast proves the weak coherence of main cable displacement and the limitation of the adjacent cable force influence. Furthermore, a tension program that is of great reference value has been developed; some important conclusions, advices, and attention points have been summarized.

  4. Anchoring and Overconfidence: The Influence of Culture and Cognitive Abilities

    Directory of Open Access Journals (Sweden)

    Czerwonka Monika

    2017-09-01

    Full Text Available Anchoring and overconfidence are some of the best-known biases in psychology and behavioral finance literature. While a number of studies have investigated the evidence of these biases and explored the motives and human factors that contribute to the one’s susceptibility to the effects, little is known about the cultural factors behind these heuristic biases. This paper aims to fill the research gap and shows the differences in proneness to the anchoring effect and overconfidence in two samples of students from Poland and India. The purpose of the study is twofold: to analyze susceptibility to behavioral effects relative to cultural background; and to consider the subjects’ cognitive abilities as a potential factor in their exposure to behavioral biases and confirm that subjects with higher cognitive skills, measured by the cognitive reflection test (CRT display less susceptibility to the above heuristic biases.

  5. Fullerene-based anchoring groups for molecular electronics.

    Science.gov (United States)

    Martin, Christian A; Ding, Dapeng; Sørensen, Jakob Kryger; Bjørnholm, Thomas; van Ruitenbeek, Jan M; van der Zant, Herre S J

    2008-10-08

    We present results on a new fullerene-based anchoring group for molecular electronics. Using lithographic mechanically controllable break junctions in vacuum we have determined the conductance and stability of single-molecule junctions of 1,4-bis(fullero[c]pyrrolidin-1-yl)benzene. The compound can be self-assembled from solution and has a low-bias conductance of 3 x 10(-4) G0. Compared to 1,4-benzenedithiol the fullerene-anchored molecule exhibits a considerably lower conductance spread. In addition, the signature of the new compound in histograms is more significant than that of 1,4-benzenediamine, probably owing to a more stable adsorption motif. Statistical analyses of the breaking of the junctions confirm the stability of the fullerene-gold bond.

  6. Organization, 'Anchoring' of Knowledge, and Innovative Activity in Construction

    DEFF Research Database (Denmark)

    Drejer, Ina; Vinding, Anker Lund

    2006-01-01

    The construction industry is characterised by the widespread use of project organisation. It has been suggested that the relatively low level of innovative activity in the industry can be explained by the temporary nature of firm boundary-crossing projects. Survey data from the Danish construction...... industry is used to investigate the importance of learning and 'anchoring' of project-specific knowledge at the firm level for participation in innovative activities. The data cover both the overall Danish construction industry and a specific region, North Jutland, which has a relatively high...... specialisation of construction workers. Latent class and regression analyses reveal that firms that make extensive use of partnering, together with internal product and process evaluation and knowledge diffusion (labelled 'knowledge-anchoring mechanisms'), are more likely to participate in innovative activities...

  7. Complications of bone-anchored hearing aid implantation.

    Science.gov (United States)

    Hobson, J C; Roper, A J; Andrew, R; Rothera, M P; Hill, P; Green, K M

    2010-02-01

    Bone-anchored hearing aid implantations have been performed in Manchester for over 20 years. This study examined a range of variables that can occur during the implantation process, and the effect they may have on successful outcome. Retrospective study and literature review. Tertiary referral centre in central Manchester. Details of 602 bone-anchored hearing aid implantation procedures were retrieved from the departmental database. The overall complication rate was 23.9 per cent. The rate of revision surgery was 12.1 per cent. This study involved a significantly larger number of patients than any previously reported, similar study. Possible reasons for differences in outcomes, and recommendations for best practice, are discussed.

  8. Crystal structures of two thiacalix[4]arene derivatives anchoring four ...

    Indian Academy of Sciences (India)

    Administrator

    Abstract. The crystal structures of two thiacalixarene derivatives anchoring thiadiazole functional groups at lower rim, C60H72O4S12N8 (1), C64H80O4S12N8 (2), have been determined by single crystal X-ray diffraction. The thiacalix[4]arene framework in both 1 and 2 adopts the 1,3-alternate conformation. Com- pound 1 ...

  9. Crystal structures of two thiacalix [4] arene derivatives anchoring ...

    Indian Academy of Sciences (India)

    The crystal structures of two thiacalixarene derivatives anchoring thiadiazole functional groups at lower rim, C60H72O4S12N8 (1), C64H80O4S12N8 (2), have been determined by single crystal X-ray diffraction. The thiacalix[4]arene framework in both 1 and 2 adopts the 1,3-alternate conformation. Compound 1 forms a 1-D ...

  10. Improved anchoring of SSS with vacuum barrier to avoid displacement

    CERN Document Server

    Capatina, O; Foreste, A; Parma, V; Renaglia, T; Quesnel, J

    2009-01-01

    As presented in the previous speech, the incident in sector 3-4 of the LHC caused a high pressure build-up inside the cryostat insulation vacuum resulting in high longitudinal forces acting on the insulation vacuum barriers. This resulted in braking floor and floor fixations of the SSS with vacuum barrier. The strategy of improving anchoring of SSS with vacuum barrier to avoid displacement is presented and discussed.

  11. [Treatment of calcaneal avulsion fractures with twinfix suture anchors fixation].

    Science.gov (United States)

    Zhao, Bin-xiu; Wang, Kun-zheng; Wang, Chun-sheng; Xie, Yue; Dai, Zhi-tang; Liu, Gang; Liu, Wei-dong

    2011-06-01

    For the calcaneal avulsion fracture, the current method is more commonly used screws or Kirschner wire to fix fracture fragment. This article intended to explore the feasibility and clinical efficacy for the treatment of avulsion fractures with TwinFix suture anchors. From July 2007 to November 2010, 21 patients were reviewed, including 15 males and 6 females, ranging in age from 49 to 65 years,with a mean of 58.7 years. Twelve patients had nodules in the right heel and 9 patients had nodules in the left heel. All the patients had closed fractures. The typical preoperative symptoms of the patients included pain in the upper heel and weak in heel lift. Body examination results: palpable sense of bone rubbing in the back of the heel, and swelling in the heel. Surgery treatment with TwinFix suture anchors performed as follows : to fix TwinFix suture anchors into the calcaneal body, then to drill the fracture block, to make the double strand suture through the fracture holes, to knot the suture eachother to fix the block, and to use stitch to fix the remaining suture in the Achilles tendon in order to improve the block fixation. The criteria of the AOFAS Foot and Ankle Surgery by the United States Association of ankle-rear foot functional recovery was used to evaluate the Achilles tendon. Total average score was (95.5 +/- 3.12) points, including pain items of(38.5 +/- 2.18) points,the average score of functional items of (49.5 +/- 3.09) points,and power lines of 10 points in all patients. Twenty-one patients got an excellent result, 16 good and 5 poor. The methods of treatment for the calcaneal avulsion fractures with TwinFix suture anchors is a simple operation, and have excellent clinical effect, which is worthy of promotion.

  12. A legged anchoring mechanism for capsule endoscopes using micropatterned adhesives.

    Science.gov (United States)

    Glass, Paul; Cheung, Eugene; Sitti, Metin

    2008-12-01

    This paper presents a new concept for an anchoring mechanism to enhance existing capsule endoscopes. The mechanism consists of three actuated legs with compliant feet lined with micropillar adhesives to be pressed into the intestine wall to anchor the device at a fixed location. These adhesive systems are inspired by gecko and beetle foot hairs. Single-leg and full capsule mathematical models of the forces generated by the legs are analyzed to understand capsule performance. Empirical friction models for the interaction of the adhesives with an intestinal substrate were experimentally determined in vitro using dry and oil-coated elastomer micropillar arrays with 140 microm pillar diameter, 105 microm spacing between pillars, and an aspect ratio of 1:1 on fresh porcine small intestine specimens. Capsule prototypes were also tested in a simulated intestine environment and compared with predicted peristaltic loads to assess the viability of the proposed design. The experimental results showed that a deployed 10 gr capsule robot can withstand axial peristaltic loads and anchor reliably when actuation forces are greater than 0.27 N using dry micropillars. Required actuation forces may be reduced significantly by using micropillars coated with a thin silicone oil layer.

  13. Do anchor investors create value for initial public offerings? An empirical investigation

    Directory of Open Access Journals (Sweden)

    Seshadev Sahoo

    2017-12-01

    Full Text Available The concept of anchor investors was introduced by the market regulator, Securities Exchange Board of India (SEBI, to bring transparency in the book building mechanism. We examine anchor investors' investment in initial public offerings (IPOs to determine how they create value for issuing firms and participating investors. Using a database of 135 IPOs issued in the Indian market through book building mechanism during 2009–2014, we find that anchor investors' investment in IPOs reduces underpricing. Larger subscription from retail investors for anchor-supported IPOs indicates that anchor investors' participation is viewed as a credible attestation of quality of the issue. We document that anchor-supported IPOs are more liquid and less volatile in the short run. We also find that by controlling for other factors such as offer size, subscription rate and age of the firm, a part of the underpricing is reduced by anchor investors.

  14. Not all nutrition claims are perceived equal: anchoring effects and moderating mechanisms in food advertising.

    Science.gov (United States)

    Paek, Hye-Jin; Yoon, Hye Jin; Hove, Thomas

    2011-03-01

    Despite the increased use of health claims in food advertising, few studies have investigated how specific nutrition claims have differential effects depending on how they are presented. In this context, the current study tests the anchoring hypothesis. Anchoring refers to a common human tendency to evaluate information differently depending on the presence or absence of a numerical "anchor" or reference point. Two (pilot and main) experimental studies explore anchoring effects on audience response to food advertising both directly and moderated by cognitive, motivational, and message factors. The pilot study finds that food product ads employing nutrition claims with an anchor rather than without an anchor generate two results: First, participants perceive the product to have lower fat/lower calorie contents (anchoring hypothesis); second, they prefer the messages with an anchor over those without an anchor. The main study reports that when anchoring is successfully evoked, it produces favorable attitudes toward the ad, favorable attitudes toward the brand, and purchase intention-but only when moderated by health orientation, claim believability, and nutrition knowledge. Practical implications are provided with respect to regulatory guidelines and effective communication strategies for promoting low-fat and low-calorie products in food advertising.

  15. Mini-open Subpectoral Biceps Tenodesis Using a Suture Anchor.

    Science.gov (United States)

    Arena, Christopher; Dhawan, Aman

    2017-10-01

    The long head of the biceps (LHB) tendon is a potential source of shoulder pain encountered by orthopaedic surgeons. A multitude of approaches to addressing LHB tendinopathy have been described. These include various surgical techniques such as tenodesis versus tenotomy, an arthroscopic versus an open approach, and differing methods of tenodesis fixation. Our preferred approach to addressing LHB tendinopathy is through a mini-open approach using a double-loaded 4.5-mm suture anchor. This Technical Note with accompanying video describes our technique for performing this procedure, as well as supporting clinical evidence and technical pearls.

  16. Flexoelectric instability in nematic cells with weak anchoring energy

    International Nuclear Information System (INIS)

    Lelidis, I.; Barbero, G.

    2003-01-01

    We analyze the role of weak anchoring energy boundary conditions on electric field induced structural instabilities of flexoelectric origin in a finite thickness nematic cell. It is shown that stripe-like domain patterns can appear above a rather low threshold voltage V th ∼0.3 V. V th and the wave-length of the instability at the threshold vary as the square root of the cell thickness. Our analysis is valid when the extrapolation length is large with respect to the nematic slab thickness

  17. Codend selectivity in a commercial Danish anchor seine

    DEFF Research Database (Denmark)

    Noack, Thomas; Frandsen, Rikke; Krag, Ludvig Ahm

    2017-01-01

    Danish seining (or anchor seining) is a fishing technique that is gaining increasing attention because itis considered to be a fuel-efficient fishing method with low environmental impact. However, scientificdocumentation of the selectivity characteristics of Danish seines is lacking, and the gear...... (Pleuronectesplatessa), was best described by models that combine two or three logistic models, which indicated thatmore than one selection process was at work. Selectivity of cod (Gadus morhua) was best described by aRichard curve and selectivity of red gurnard (Chelidonichthys lucernus) by a logistic curve...

  18. Trafficking of glycosylphosphatidylinositol anchored proteins from the endoplasmic reticulum to the cell surface

    Science.gov (United States)

    Muñiz, Manuel; Riezman, Howard

    2016-01-01

    In eukaryotes, many cell surface proteins are attached to the plasma membrane via a glycolipid glycosylphosphatidylinositol (GPI) anchor. GPI-anchored proteins (GPI-APs) receive the GPI anchor as a conserved posttranslational modification in the lumen of the endoplasmic reticulum (ER). After anchor attachment, the GPI anchor is structurally remodeled to function as a transport signal that actively triggers the delivery of GPI-APs from the ER to the plasma membrane, via the Golgi apparatus. The structure and composition of the GPI anchor confer a special mode of interaction with membranes of GPI-APs within the lumen of secretory organelles that lead them to be differentially trafficked from other secretory membrane proteins. In this review, we examine the mechanisms by which GPI-APs are selectively transported through the secretory pathway, with special focus on the recent progress made in their actively regulated export from the ER and the trans-Golgi network. PMID:26450970

  19. Membrane curvature enables N-Ras lipid anchor sorting to liquid-ordered membrane phases

    DEFF Research Database (Denmark)

    Larsen, Jannik Bruun; Jensen, Martin Borch; Bhatia, Vikram Kjøller

    2015-01-01

    Trafficking and sorting of membrane-anchored Ras GTPases are regulated by partitioning between distinct membrane domains. Here, in vitro experiments and microscopic molecular theory reveal membrane curvature as a new modulator of N-Ras lipid anchor and palmitoyl chain partitioning. Membrane curva...... curvature was essential for enrichment in raft-like liquid-ordered phases; enrichment was driven by relief of lateral pressure upon anchor insertion and most likely affects the localization of lipidated proteins in general....

  20. SNP discovery and chromosome anchoring provide the first physically-anchored hexaploid oat map and reveal synteny with model species.

    Directory of Open Access Journals (Sweden)

    Rebekah E Oliver

    Full Text Available A physically anchored consensus map is foundational to modern genomics research; however, construction of such a map in oat (Avena sativa L., 2n = 6x = 42 has been hindered by the size and complexity of the genome, the scarcity of robust molecular markers, and the lack of aneuploid stocks. Resources developed in this study include a modified SNP discovery method for complex genomes, a diverse set of oat SNP markers, and a novel chromosome-deficient SNP anchoring strategy. These resources were applied to build the first complete, physically-anchored consensus map of hexaploid oat. Approximately 11,000 high-confidence in silico SNPs were discovered based on nine million inter-varietal sequence reads of genomic and cDNA origin. GoldenGate genotyping of 3,072 SNP assays yielded 1,311 robust markers, of which 985 were mapped in 390 recombinant-inbred lines from six bi-parental mapping populations ranging in size from 49 to 97 progeny. The consensus map included 985 SNPs and 68 previously-published markers, resolving 21 linkage groups with a total map distance of 1,838.8 cM. Consensus linkage groups were assigned to 21 chromosomes using SNP deletion analysis of chromosome-deficient monosomic hybrid stocks. Alignments with sequenced genomes of rice and Brachypodium provide evidence for extensive conservation of genomic regions, and renewed encouragement for orthology-based genomic discovery in this important hexaploid species. These results also provide a framework for high-resolution genetic analysis in oat, and a model for marker development and map construction in other species with complex genomes and limited resources.

  1. Post-installed concrete anchors in nuclear power plants: Performance and qualification

    International Nuclear Information System (INIS)

    Mahrenholtz, Philipp; Eligehausen, Rolf

    2015-01-01

    Graphical abstract: - Highlights: • Review of qualification and design regulations for anchors in nuclear power plants. • First complete set of nuclear anchor load–displacement data and its evaluation ever. • Demonstration of robust test behavior of a qualified post-installed anchor product. - Abstract: In nuclear power plants (NPPs), post-installed anchors are widely used for structural and non-structural connections to concrete. In many countries, anchor products employed for safety relevant applications have to be approved by the authorities. For the high safety standards in force for NPPs, special requirements have to be met to allow for extreme design situations. This paper presents an experimental test program conducted to evaluate the performance of anchors according to the German Guideline for Anchorages in Nuclear Power Plants and Nuclear Technology Installations (DIBt KKW Leitfaden, 2010). After a brief introduction to anchor behavior and the regulative context, the results of tension and shear tests carried out on undercut anchors are discussed. Robust load capacities and relatively small displacements determined for demanding load and crack cycling tests demonstrated the suitability of anchors qualified according to a state-of-the-art qualification guideline

  2. Reinforcing mechanism of anchors in slopes: a numerical comparison of results of LEM and FEM

    Science.gov (United States)

    Cai, Fei; Ugai, Keizo

    2003-06-01

    This paper reports the limitation of the conventional Bishop's simplified method to calculate the safety factor of slopes stabilized with anchors, and proposes a new approach to considering the reinforcing effect of anchors on the safety factor. The reinforcing effect of anchors can be explained using an additional shearing resistance on the slip surface. A three-dimensional shear strength reduction finite element method (SSRFEM), where soil-anchor interactions were simulated by three-dimensional zero-thickness elasto-plastic interface elements, was used to calculate the safety factor of slopes stabilized with anchors to verify the reinforcing mechanism of anchors. The results of SSRFEM were compared with those of the conventional and proposed approaches for Bishop's simplified method for various orientations, positions, and spacings of anchors, and shear strengths of soil-grouted body interfaces. For the safety factor, the proposed approach compared better with SSRFEM than the conventional approach. The additional shearing resistance can explain the influence of the orientation, position, and spacing of anchors, and the shear strength of soil-grouted body interfaces on the safety factor of slopes stabilized with anchors.

  3. The anchors of steel wire ropes, testing methods and their results

    Directory of Open Access Journals (Sweden)

    J. Krešák

    2012-10-01

    Full Text Available The present paper introduces an application of the acoustic and thermographic method in the defectoscopic testing of immobile steel wire ropes at the most critical point, the anchor. First measurements and their results by these new defectoscopic methods are shown. In defectoscopic tests at the anchor, the widely used magnetic method gives unreliable results, and therefore presents a problem for steel wire defectoscopy. Application of the two new methods in the steel wire defectoscopy at the anchor point will enable increased safety measures at the anchor of steel wire ropes in bridge, roof, tower and aerial cable lift constructions.

  4. Cognitive Advantages of Blending with Material Anchors in Energy Instruction

    Science.gov (United States)

    Close, Hunter; Close, Eleanor; Scherr, Rachel; McKagan, Sarah

    2012-03-01

    Conceptual blending theory [1] explains how the human imagination creates unreal situations that help us think about reality. In these imaginary blended situations, we establish new correspondences, interactions, and dynamics, and the outcomes of the dynamics lend insight to the nature of various real situations that were used to compose the blend. Blends are not just in the head, however; in some cases, a material system participates in the blend by lending its material structure as conceptual structure [2]. In the instructional activity Energy Theater [3], people represent units of energy and move around in order to solve puzzles of energy transfer and transformation. We use the ideas of blending and material anchors to understand how learners are able to use the representation to their cognitive advantage. [4pt] [1] Fauconnier, G. & Turner, M. (2002). The Way We Think: Conceptual Blending and the Mind's Hidden Complexities. New York: Basic Books.[0pt] [2] Hutchins, E. (2005) Material anchors for conceptual blends. Journal of Pragmatics 37, 1555-1577.[0pt] [3] Scherr, R. E., Close, H. G., McKagan, S. B., & Close, E. W. (2010) ``Energy Theater'': Using the body symbolically to understand energy. In C. Singh, M. Sabella, & S. Rebello (Eds.) 2010 PERC Proceedings. Melville, NY: AIP Press.

  5. Anchored Clathrate Waters Bind Antifreeze Proteins to Ice

    Energy Technology Data Exchange (ETDEWEB)

    C Garnham; R Campbell; P Davies

    2011-12-31

    The mechanism by which antifreeze proteins (AFPs) irreversibly bind to ice has not yet been resolved. The ice-binding site of an AFP is relatively hydrophobic, but also contains many potential hydrogen bond donors/acceptors. The extent to which hydrogen bonding and the hydrophobic effect contribute to ice binding has been debated for over 30 years. Here we have elucidated the ice-binding mechanism through solving the first crystal structure of an Antarctic bacterial AFP. This 34-kDa domain, the largest AFP structure determined to date, folds as a Ca{sup 2+}-bound parallel beta-helix with an extensive array of ice-like surface waters that are anchored via hydrogen bonds directly to the polypeptide backbone and adjacent side chains. These bound waters make an excellent three-dimensional match to both the primary prism and basal planes of ice and in effect provide an extensive X-ray crystallographic picture of the AFP{vert_ellipsis}ice interaction. This unobstructed view, free from crystal-packing artefacts, shows the contributions of both the hydrophobic effect and hydrogen bonding during AFP adsorption to ice. We term this mode of binding the 'anchored clathrate' mechanism of AFP action.

  6. Anchored PKA as a gatekeeper for gap junctions.

    Science.gov (United States)

    Pidoux, Guillaume; Taskén, Kjetil

    2015-01-01

    Anchored protein kinase A (PKA) bound to A Kinase Anchoring Protein (AKAP) mediates effects of localized increases in cAMP in defined subcellular microdomains and retains the specificity in cAMP-PKA signaling to distinct extracellular stimuli. Gap junctions are pores between adjacent cells constituted by connexin proteins that provide means of communication and transfer of small molecules. While the PKA signaling is known to promote human trophoblast cell fusion, the gap junction communication through connexin 43 (Cx43) is a prerequisite for this process. We recently demonstrated that trophoblast fusion is regulated by ezrin, a known AKAP, which binds to Cx43 and delivers PKA in the vicinity gap junctions. We found that disruption of the ezrin-Cx43 interaction abolished PKA-dependent phosphorylation of Cx43 as well as gap junction communication and subsequently cell fusion. We propose that the PKA-ezrin-Cx43 macromolecular complex regulating gap junction communication constitutes a general mechanism to control opening of Cx43 gap junctions by phosphorylation in response to cAMP signaling in various cell types.

  7. Studies on the mechanical behavior of rock anchors. ; Results of in-situ pull-out tests. Rock anchor no rikigaku kyodo ni kansuru kenkyu. ; Gen prime ichi shiken ni okeru anchor no kyodo

    Energy Technology Data Exchange (ETDEWEB)

    Arimoto, K.; Ebisu, S.; Nakagawa, M.; Usui, M.; Someya, T.; Machida, N. (Okumura Corp., Tokyo (Japan))

    1991-10-31

    The rock anchor method is planned to apply to some permanent structures but since this method was developed for temporary structures, the clarification of the transferring mechanism of force from an anchor to a rockmass, the fracture mechanism and the development of the dynamic model have not been established. This paper arranged the data obtained by a full-scale, in-situ pulling out test of a rock anchor as the first step to understand the dynamic behavior and analyzed by paying attetion to the modulus of deformation of the rockmass where the anchor was embedded to elucidate the affecting degree of rockmass modulus of deformation, the embedded length and the tendon diameter on the dynamic behavior of the anchor. The rock anchor behavior could be expressed accurately by applying a theoretical solution derived by the balancing condition of forces at the boundary face. Especially, when the rockmass is uniform and the fracture occurrs at the interface between the tendon and grout, this approach can express the fracture with the accuracy similar to that made by the finite element method. 6 refs., 11 figs.,1 tab.

  8. C-Anchor for Strengthening the Connection between Adhesively Bonded Laminates and Concrete Substrates

    Directory of Open Access Journals (Sweden)

    Ghani Razaqpur

    2015-11-01

    Full Text Available A new carbon fiber reinforced polymer (CFRP anchor is developed and tested to delay debonding in reinforced concrete (RC beams externally strengthened with FRP laminate/sheet. The C-shape anchor is made from a commercially available CFRP grid. The anchors legs are 95 mm long while the spacing between the legs is adjustable, depending on FRP laminate and beam widths. Nine full scale RC beams, 3.0 m long, 250 mm wide and 400 mm deep, were strengthened with CFRP laminate/sheet, with and without the C-anchor. The main test parameters were the type and amount of FRP laminate and the presence/absence of the anchor. Test results showed that beams with the anchor had generally 5%–10% higher debonding and failure load, and they reached higher deflection at failure than the companion beams without anchors. Although complete separation of the FRP laminate from the concrete was not observed in any of the beams with anchors, there was noticeable slip at failure at one end of the laminate. A significant outcome of the study is that anchors are effective in limiting the extent of debonding along the laminate, thus contributing to the flexural stiffness of the beam by reducing the extent of cracking and limiting the crack width along the beam. Finally, the anchor allowed the FRP to reach or exceed its theoretically allowable strain computed based on the American Concrete Institute (ACI Committee 440 recommendation while in none of the beams without anchors, the FRP reached its theoretically allowable strain.

  9. Impingement syndrome of the shoulder following double row suture anchor technique for arthroscopic rotator cuff repair: a case report

    Directory of Open Access Journals (Sweden)

    Rambani Rohit

    2009-06-01

    Full Text Available Abstract Introduction Arthroscopic repair of the rotator cuff is a demanding surgery. Accurate placement of anchors is key to success. Case presentation A 38-year-old woman received arthroscopic repair of her rotator cuff using a double row suture anchor technique. Postoperatively, she developed impingement syndrome which resulted from vertical displacement of a suture anchor once the shoulder was mobilised. The anchor was removed eight weeks following initial surgery and the patient had an uneventful recovery. Conclusion Impingement syndrome following arthroscopic repair of the rotator cuffs using double row suture anchor has not been widely reported. This is the first such case where anchoring has resulted in impingement syndrome.

  10. Stone anchors from Sindhudurg Fort on the west coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Tripati, S.; Gaur, A.S.

    , of which there are triangular and three grapnet-type, used to construct the jetty along with the locally available sand stone. The two remaining grapnet-type anchors are erected on the jetty for mooring purposes. It is found that none of the anchors were...

  11. 48 CFR 252.225-7019 - Restriction on acquisition of anchor and mooring chain.

    Science.gov (United States)

    2010-10-01

    ... of anchor and mooring chain. 252.225-7019 Section 252.225-7019 Federal Acquisition Regulations System... and mooring chain. As prescribed in 225.7007-3, use the following clause: Restriction on Acquisition of Anchor and Mooring Chain (DEC 2009)) (a) Definition. “Component,” as used in this clause, means an...

  12. Arsonic acid as a robust anchor group for the surface modification of Fe3O4.

    Science.gov (United States)

    Ahn, Jihoon; Moon, Doo-Sik; Lee, Jin-Kyu

    2013-12-03

    In order to use iron oxide nanoparticles (Fe3O4) in various applications, a surface modification that provides colloidal stability and additional functionality to the nanoparticles is necessary. For the modification of the nanoparticle surface with ligand molecules, the ligand molecule should contain an anchor group that has a strong affinity for the surface. However, currently used anchor groups have shown some problems such as low affinity and stability as well as reactivity with the surface. In this study, arsonic acid (RAsO(OH)2) was investigated as a novel anchor group. It was possible to introduce azide groups on the surface of iron oxide nanoparticles using 4-azidophenylarsonic acid, and the desired functional molecules could be chemically attached to the surface via copper-catalyzed azide-alkyne cycloaddition (click chemistry). By quantifying and comparing the amount of attached anchors on the surface, it was found that arsonic acid displays better affinity than other currently used anchors (catechol, carboxylic acid). Furthermore, we examined the binding reversibility, long-term anchoring stability, and anchoring stability at various pH values. It was revealed that arsonic acid is a stable anchor in various conditions.

  13. The affordance of anchored discussion for the collaborative processing of academic texts.

    NARCIS (Netherlands)

    van der Pol, Jakko; Admiraal, W.|info:eu-repo/dai/nl/120226340; Simons, P.R.J.|info:eu-repo/dai/nl/068032994

    2006-01-01

    A system for ‘anchored discussion’ is compared with a system for traditional forum discussion (Blackboard), and their affordances for the collaborative processing of academic texts are investigated. Results show that discussion in the system for anchored discussion is directed at a processing of the

  14. A group of 20 stone anchors from the waters of Dwarka, on the Gujarat Coast, India

    Digital Repository Service at National Institute of Oceanography (India)

    Gaur, A.S.; Sundaresh; Tripati, S.; Gudigar, P.; Vora, K.H.; Bandodkar, S.N.

    suggesting an anchorage. Twenty stone anchors of three types located in a submerged channel on the southern side of the site. The grapnel type of anchor is associated with Indo-Arab trade between the 8th and 16th centuries AD. The triangular or composite...

  15. Management of subluxated capsular bag-fixated intraocular lenses using a capsular anchor.

    Science.gov (United States)

    Ton, Yokrat; Naftali, Modi; Gortzak, Ruth Lapid; Assia, Ehud I

    2016-05-01

    We describe the use of the capsular anchor (AssiAnchor) to manage a subluxated intraocular lens (IOL) in the capsular bag. The anchor comprises 2 prongs that hold the anterior lens capsule and a central rod that is sutured to the scleral wall, enabling centration of the IOL-capsular bag complex. Six pseudophakic patients presenting with subluxated posterior chamber IOLs in the capsular bag were operated on using the device. The anchor was used successfully in all cases, although in 2 cases only 1 prong was placed under the capsulorhexis edge. In 1 eye, 2 anchors were used 1 month apart following repeated traumatic zonular injury. The capsular bag holding the IOL remained centered and stable throughout the follow-up period. The anchoring device, which was originally designed to preserve the lens capsule and stabilize subluxated crystalline lenses, can also be used to treat subluxation of a capsular bag-fixated IOL. Dr. Assia is the inventor of the AssiAnchor, has a licensed patent of the anchor, and is consultant to Hanita Lenses. Dr. Lapid-Gortzak is a consultant to and speaker for Alcon Surgical, Inc., Hanita Lenses, Orca Surgical, and Sanoculis Ltd.; a speaker for Santen; and a consultant to Icon. Drs. Ton and Naftali have no financial or proprietary interest in any material or method mentioned. Copyright © 2016 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.

  16. Model test of anchoring effect on zonal disintegration in deep surrounding rock masses.

    Science.gov (United States)

    Chen, Xu-Guang; Zhang, Qiang-Yong; Wang, Yuan; Liu, De-Jun; Zhang, Ning

    2013-01-01

    The deep rock masses show a different mechanical behavior compared with the shallow rock masses. They are classified into alternating fractured and intact zones during the excavation, which is known as zonal disintegration. Such phenomenon is a great disaster and will induce the different excavation and anchoring methodology. In this study, a 3D geomechanics model test was conducted to research the anchoring effect of zonal disintegration. The model was constructed with anchoring in a half and nonanchoring in the other half, to compare with each other. The optical extensometer and optical sensor were adopted to measure the displacement and strain changing law in the model test. The displacement laws of the deep surrounding rocks were obtained and found to be nonmonotonic versus the distance to the periphery. Zonal disintegration occurs in the area without anchoring and did not occur in the model under anchoring condition. By contrasting the phenomenon, the anchor effect of restraining zonal disintegration was revealed. And the formation condition of zonal disintegration was decided. In the procedure of tunnel excavation, the anchor strain was found to be alternation in tension and compression. It indicates that anchor will show the nonmonotonic law during suppressing the zonal disintegration.

  17. Model Test of Anchoring Effect on Zonal Disintegration in Deep Surrounding Rock Masses

    Directory of Open Access Journals (Sweden)

    Xu-Guang Chen

    2013-01-01

    Full Text Available The deep rock masses show a different mechanical behavior compared with the shallow rock masses. They are classified into alternating fractured and intact zones during the excavation, which is known as zonal disintegration. Such phenomenon is a great disaster and will induce the different excavation and anchoring methodology. In this study, a 3D geomechanics model test was conducted to research the anchoring effect of zonal disintegration. The model was constructed with anchoring in a half and nonanchoring in the other half, to compare with each other. The optical extensometer and optical sensor were adopted to measure the displacement and strain changing law in the model test. The displacement laws of the deep surrounding rocks were obtained and found to be nonmonotonic versus the distance to the periphery. Zonal disintegration occurs in the area without anchoring and did not occur in the model under anchoring condition. By contrasting the phenomenon, the anchor effect of restraining zonal disintegration was revealed. And the formation condition of zonal disintegration was decided. In the procedure of tunnel excavation, the anchor strain was found to be alternation in tension and compression. It indicates that anchor will show the nonmonotonic law during suppressing the zonal disintegration.

  18. Unlocking Hospitality Managers Career Transitions through Applying Schein's Career Anchors Theory

    Science.gov (United States)

    McGuire, David; Polla, Giovana; Heidl, Britta

    2017-01-01

    Purpose: This paper seeks to unlock the career transitions of hospitality managers through applying Schein's career anchors theory. It seeks to understand how Schein's Career Anchors help explain the career transitions of managers in the Scottish hospitality industry. Design/methodology/approach: The paper adopts a non-sequential multi-method…

  19. Structural models of the membrane anchors of envelope glycoproteins E1 and E2 from pestiviruses

    International Nuclear Information System (INIS)

    Wang, Jimin; Li, Yue; Modis, Yorgo

    2014-01-01

    The membrane anchors of viral envelope proteins play essential roles in cell entry. Recent crystal structures of the ectodomain of envelope protein E2 from a pestivirus suggest that E2 belongs to a novel structural class of membrane fusion machinery. Based on geometric constraints from the E2 structures, we generated atomic models of the E1 and E2 membrane anchors using computational approaches. The E1 anchor contains two amphipathic perimembrane helices and one transmembrane helix; the E2 anchor contains a short helical hairpin stabilized in the membrane by an arginine residue, similar to flaviviruses. A pair of histidine residues in the E2 ectodomain may participate in pH sensing. The proposed atomic models point to Cys987 in E2 as the site of disulfide bond linkage with E1 to form E1–E2 heterodimers. The membrane anchor models provide structural constraints for the disulfide bonding pattern and overall backbone conformation of the E1 ectodomain. - Highlights: • Structures of pestivirus E2 proteins impose constraints on E1, E2 membrane anchors. • Atomic models of the E1 and E2 membrane anchors were generated in silico. • A “snorkeling” arginine completes the short helical hairpin in the E2 membrane anchor. • Roles in pH sensing and E1–E2 disulfide bond formation are proposed for E1 residues. • Implications for E1 ectodomain structure and disulfide bonding pattern are discussed

  20. Structural models of the membrane anchors of envelope glycoproteins E1 and E2 from pestiviruses

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Jimin, E-mail: jimin.wang@yale.edu; Li, Yue; Modis, Yorgo, E-mail: yorgo.modis@yale.edu

    2014-04-15

    The membrane anchors of viral envelope proteins play essential roles in cell entry. Recent crystal structures of the ectodomain of envelope protein E2 from a pestivirus suggest that E2 belongs to a novel structural class of membrane fusion machinery. Based on geometric constraints from the E2 structures, we generated atomic models of the E1 and E2 membrane anchors using computational approaches. The E1 anchor contains two amphipathic perimembrane helices and one transmembrane helix; the E2 anchor contains a short helical hairpin stabilized in the membrane by an arginine residue, similar to flaviviruses. A pair of histidine residues in the E2 ectodomain may participate in pH sensing. The proposed atomic models point to Cys987 in E2 as the site of disulfide bond linkage with E1 to form E1–E2 heterodimers. The membrane anchor models provide structural constraints for the disulfide bonding pattern and overall backbone conformation of the E1 ectodomain. - Highlights: • Structures of pestivirus E2 proteins impose constraints on E1, E2 membrane anchors. • Atomic models of the E1 and E2 membrane anchors were generated in silico. • A “snorkeling” arginine completes the short helical hairpin in the E2 membrane anchor. • Roles in pH sensing and E1–E2 disulfide bond formation are proposed for E1 residues. • Implications for E1 ectodomain structure and disulfide bonding pattern are discussed.

  1. Anchoring FRP Composite Armor in Flexible Offshore Riser Systems

    DEFF Research Database (Denmark)

    Costache, Andrei

    of composite materials. One of the problems related to the substitution of tensile steel members is that anchoring in the metallic end fittings of the pipe is very challenging.The purpose of this thesis is to ensure the transfer of tensile loads between a unidirectional fiber reinforced polymer and a metallic...... element model was constructed for each of the experimental configurations. Initial effort is used to understand the behavior of the grip and obtain good accuracy with the finite element model. Experimental data is used as input. The model makes it possible to visualize the piece-wise onset of movement...... of the grip system. Analysis of the boundary conditions show that several technical solutions can be chosen,without sacrificing performance. It is possible to create grips to fit a wide variety of constructive solutions....

  2. Smos Land Product Validation Activities at the Valencia Anchor Station

    Science.gov (United States)

    Lopez-Baeza, Ernesto

    ABSTRACT Soil moisture is a key parameter controlling the exchanges between the land surface and the atmosphere. In spite of being important for weather and climate modeling, this parameter is not well observed at a global scale. The SMOS (Soil Moisture and Ocean Salinity) Mission was designed by the European Space Agency (ESA) to measure soil moisture over continental surfaces as well as surface salinity over the oceans. Since 2001, the Valencia Anchor Station is currently being prepared for the validation of SMOS land products, namely soil moisture content and vegetation water content. The site has recently been selected by the Mission as a core validation site, mainly due to the reasonable homogeneous characteristics of the area which make it appropriate to undertake the validation of SMOS Level 2 land products during the Mission Commissioning Phase, before attempting more complex areas. Close to SMOS launch, ESA has defined and designed a SMOS V alidation Rehearsal C ampaign P lan which purpose is to repeat the Commissioning Phase execution with all centers, all tools, all participants, all structures, all data available, assuming all tools and structures are ready and trying to produce as close as possible the post-launch conditions. The aim is to test the readiness, the ensemble coordination and the speed of operations, and to avoid as far as possible any unexpected deficiencies of the plan and procedure during the real C ommissioning P hase campaigns. For the rehearsal activity, a control area of 10 x 10 km2 has been chosen at the Valencia Anchor Station study area where a network of ground soil moisture measuring stations is being set up based on the definition of homogeneous physio-hydrological units, attending to climatic, soil type, lithology, geology, elevation, slope and vegetation cover conditions. These stations are linked via a wireless communication system to a master post accessible via internet. The ground soil moisture stations will also be used

  3. Associative self-anchoring interacts with obtainability of chosen objects

    Directory of Open Access Journals (Sweden)

    Dean eMobbs

    2016-01-01

    Full Text Available While there is evidence that implicit self-esteem transfers to chosen objects (associative self-anchoring, it is still unknown whether this phenomenon extends to explicit self-esteem. Moreover, whether the knowledge that these objects might belong to the self in the future or not affects the evaluation of these objects has yet to be tested. Here, we demonstrate that evaluations of chosen objects are further enhanced when they are obtainable as compared to when they are not in participants with high explicit self-esteem, whereas participants with low explicit self-esteem exhibit the opposite pattern. These findings extend previous results and shed new light on the role of self-esteem in altering preferences for chosen objects depending on their obtainability.

  4. Mechanical Characteristics Analysis of Surrounding Rock on Anchor Bar Reinforcement

    Science.gov (United States)

    Gu, Shuan-cheng; Zhou, Pan; Huang, Rong-bin

    2018-03-01

    Through the homogenization method, the composite of rock and anchor bar is considered as the equivalent material of continuous, homogeneous, isotropic and strength parameter enhancement, which is defined as reinforcement body. On the basis of elasticity, the composite and the reinforcement are analyzed, Based on strengthening theory of surrounding rock and displacement equivalent conditions, the expression of reinforcement body strength parameters and mechanical parameters is deduced. The example calculation shows that the theoretical results are close to the results of the Jia-mei Gao[9], however, closer to the results of FLAC3D numerical simulation, it is proved that the model and surrounding rock reinforcement body theory are reasonable. the model is easy to analyze and calculate, provides a new way for determining reasonable bolt support parameters, can also provides reference for the stability analysis of underground cavern bolting support.

  5. Phosphatidylinositol anchor of HeLa cell alkaline phosphatase

    International Nuclear Information System (INIS)

    Jemmerson, R.; Low, M.G.

    1987-01-01

    Alkaline phosphatase from cancer cells, HeLa TCRC-1, was biosynthetically labeled with either 3 H-fatty acids or [ 3 H]ethanolamine as analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and fluorography of immunoprecipitated material. Phosphatidylinositol-specific phospholipase C (PI-PLC) released a substantial proportion of the 3 H-fatty acid label from immunoaffinity-purified alkaline phosphatase but had no effect on the radioactivity of [ 3 H]ethanolamine-labeled material. PI-PLC also liberated catalytically active alkaline phosphatase from viable cells, and this could be selectively blocked by monoclonal antibodies to alkaline phosphatase. However, the alkaline phosphatase released from 3 H-fatty acid labeled cells by PI-PLC was not radioactive. By contrast, treatment with bromelain removed both the 3 H-fatty acid and the [ 3 H]ethanolamine label from purified alkaline phosphatase. Subtilisin was also able to remove the [ 3 H]ethanolamine label from the purified alkaline phosphatase. The 3 H radioactivity in alkaline phosphatase purified from [ 3 H]ethanolamine-labeled cells comigrated with authentic [ 3 H]ethanolamine by anion-exchange chromatography after acid hydrolysis. The data suggest that the 3 H-fatty acid and [ 3 H]ethanolamine are covalently attached to the carboxyl-terminal segment since bromelain and subtilisin both release alkaline phosphatase from the membrane by cleavage at that end of the polypeptide chain. The data are consistent with findings for other proteins recently shown to be anchored in the membrane through a glycosylphosphatidylinositol structure and indicate that a similar structure contributes to the membrane anchoring of alkaline phosphatase

  6. Baculovirus Surface Display Using Infuenza Neuraminidase (NA Transmembrane Anchor

    Directory of Open Access Journals (Sweden)

    Irisa Trianti

    2016-11-01

    Full Text Available Baculovirus surface display has been employed as an excellent tools for presentation of foreign peptides and proteins on virus surface with native conformation, functions and immunogenicity. A baculovirus major envelope protein, gp64, or a capsid protein, vp39 are generally used as fusion partners for displaying of polypeptides on the surface of virions. Alternatively, a membrane anchoring domain of vesicular stomatitis virus G protein (VSV-G can also be used. In this study, an influenza neuraminidase (NA was proposed as a new membrane anchor for the display of Angiotensin II (AngII, DRVYIHPFHL, peptides. The AngII peptides were inserted into NA by replacing NA amino acid number 60-67 with AngII, and then integrated into a baculovirus genome. A recombinant baculovirus expressing the NA fusion-AngII peptides was generated from infected insect cells. Those peptides were found to express and translocated on the membrane of the baculovirus infected insect cell (Sf9 cell as detected by immunocytochemistry using anti-AngII monoclonal antibody. Upon budding of the recombinant baculovirus progenies through the insect cells membrane, the recombinant NA-AngII peptides was acquired to envelopes of the new baculovirus progenies. The conformation of NA on baculovirus surface was not affected by the deletion, as the 55 kDa band of NA can be detected from Western Blotting analysis by specific anti-NA monoclonal antibody. In addition, the same protein was also found by anti-AngII antibody indicating that the AngII peptides had been successfully fused with the recombinant NA. Interestingly, electron microscopy analysis demonstrated that not only the recombinant baculovirus displaying AngII peptides were generated by infected insect cells, but also the NA virus-like-particle displaying AngII peptides.

  7. [Interceptive treatment of maxillary hypoplasia with the use of bone anchors. A review of the literature].

    Science.gov (United States)

    Vermeulen, F M J; De Clerck, H J; van Beek, H; Becking, A G

    2014-02-01

    A Class III malocclusion is mainly caused by a hypoplastic maxilla and therefore the treatment is principally aimed at stimulating the growth of the maxilla. Disadvantages of conventional treatment methods are that treatment effects are mainly dentoalveolar rather than skeletal and that there is often an increase in the height of the lowerface. Moreover, patients are not always cooperative about wearing extra-oral appliances. Because of these disadvantages, a new treatment approach has been developed which makes use of skeletal anchoring. In this new technique, called 'bone anchored maxillary protraction, bone anchors are placed on both sides of the maxilla and the mandibula, onto which Class III elastics are attached. The literature shows that good results have been achieved with this method. Disadvantages of this method are that the placement of the bone anchors requires a surgical procedure and that complications, like the loosening or breaking of the anchors, can occur.

  8. Functionalized Nanostructures: Redox-Active Porphyrin Anchors for Supramolecular DNA Assemblies

    KAUST Repository

    Börjesson, Karl

    2010-09-28

    We have synthesized and studied a supramolecular system comprising a 39-mer DNA with porphyrin-modified thymidine nucleosides anchored to the surface of large unilamellar vesicles (liposomes). Liposome porphyrin binding characteristics, such as orientation, strength, homogeneity, and binding site size, was determined, suggesting that the porphyrin is well suited as a photophysical and redox-active lipid anchor, in comparison to the inert cholesterol anchor commonly used today. Furthermore, the binding characteristics and hybridization capabilities were studied as a function of anchor size and number of anchoring points, properties that are of importance for our future plans to use the addressability of these redox-active nodes in larger DNA-based nanoconstructs. Electron transfer from photoexcited porphyrin to a lipophilic benzoquinone residing in the lipid membrane was characterized by steady-state and time-resolved fluorescence and verified by femtosecond transient absorption. © 2010 American Chemical Society.

  9. Development and validation of European guidelines for seismic qualification of post-installed anchors.

    Science.gov (United States)

    Mahrenholtz, Philipp; Wood, Richard L; Eligehausen, Rolf; Hutchinson, Tara C; Hoehler, Matthew S

    2017-10-01

    This paper presents the technical background for the seismic qualification procedures for post-installed anchors in the European Technical Approval Guideline (ETAG 001) seismic annex issued in 2013. We discuss requirements for a comprehensive guideline and reference supporting documentation. Numerical studies to generate new simulated seismic protocols for anchors are summarized with focus on their application to Europe. To reduce the time and cost of anchor product qualification testing while fulfilling the requirement of European building codes to assess two performance categories, we combine the results of our numerical studies to generate novel testing protocols that allow for the assessment of anchor behavior at multiple levels in a unified protocol. Validation tests demonstrate that the unified protocol results in anchor performance comparable with that achieved in multiple, single-performance-level tests.

  10. The detrimental consequences for seagrass of ineffective marine park management related to boat anchoring.

    Science.gov (United States)

    La Manna, G; Donno, Y; Sarà, G; Ceccherelli, G

    2015-01-15

    Posidonia oceanica (L.) Delile meadows are recognized as priority habitat for conservation by the EU Habitats Directive. The La Maddalena Archipelago National Park (Mediterranean Sea) P. oceanica meadow, the dominant coastal habitat of the area, is mostly threatened by boat anchoring. 12 years after the establishment of mooring fields and anchoring restrictions, a study was conducted to measure their effectiveness on the conservation of seagrass and the mitigation of anchoring damage. We found that: (i) the condition of P. oceanica was disturbed, both in the mooring fields and in control locations; (ii) mooring fields and anchoring restrictions did not show to be an efficient system for the protection of seagrass, in fact anchor scars increased after the tourist season; (iii) the mooring systems had an impact on the surrounding area of the meadow, probably due to their misuse. On the basis of these results, management recommendations for marine parks are proposed. Copyright © 2014 Elsevier Ltd. All rights reserved.

  11. Influences of surface and flexoelectric polarization on the effective anchoring energy in nematic liquid crystal

    International Nuclear Information System (INIS)

    Guan Rong-Hua; Ye Wen-Jiang; Xing Hong-Yu

    2015-01-01

    The physical effects on surface and flexoelectric polarization in a weak anchoring nematic liquid crystal cell are investigated systematically. We derive the analytic expressions of two effective anchoring energies for lower and upper substrates respectively as well as their effective anchoring strengths and corresponding tilt angles of effective easy direction. All of these quantities are relevant to the magnitudes of both two polarizations and the applied voltage U. Based on these expressions, the variations of effective anchoring strength and the tilt angle with the applied voltage are calculated for the fixed values of two polarizations. For an original weak anchoring hybrid aligned nematic cell, it may be equivalent to a planar cell for a small value of U and has a threshold voltage. The variation of reduced threshold voltage with reduced surface polarization strength is also calculated. The role of surface polarization is important without the adsorptive ions considered. (paper)

  12. Experimental Study On Lateral Load Capacity of Bamboo RC Beam Column Joints Strengthened By Bamboo Mechanical Anchors

    Directory of Open Access Journals (Sweden)

    Sri Umniati B.

    2017-01-01

    Full Text Available In this paper, the prospective of bamboos which available abundantly especially in Indonesia as rebars and mechanical anchors are studied. And also the endurance of the bamboos mechanical anchors to withstand cyclic loading were observed. Nine classes of bamboos bar were evaluated: consist of 3 different anchors (0, 4 and 8 anchors and 3 different compressive strength (19.19 MPa, 29.61 MPa and 37.96 MPa means 3 × 3 parameters. The results show that the lateral load capacity increased significantly with the present of bamboo anchors specimens: 26.04 % for 4 anchors specimens (C2 and 25 % for the 8 anchors specimens (C3 compared to zero anchor specimens (C1. On the other hand, the compressive strength of concrete have no significant effects to the lateral load capacity. Overall it can be concluded that, bamboo can be used as mechanical anchorage to strengthen beam column joint.

  13. Linking Composite Scores: Effects of Anchor Test Length and Content Representativeness. Research Report. ETS RR-16-36

    Science.gov (United States)

    Lin, Peng; Dorans, Neil; Weeks, Jonathan

    2016-01-01

    The nonequivalent groups with anchor test (NEAT) design is frequently used in test score equating or linking. One important assumption of the NEAT design is that the anchor test is a miniversion of the 2 tests to be equated/linked. When the content of the 2 tests is different, it is not possible for the anchor test to be adequately representative…

  14. The electronic transport properties of B40fullerenes with chalcogens as anchor atoms.

    Science.gov (United States)

    Kaur, Rupendeep; Kaur, Jupinder

    2017-11-22

    Fullerenes are the most popular molecules to use in applications related to molecular electronics because of their superconductive nature. These molecules show a diverse range of properties, including optical, electronic, and structural characteristics. In this work, we focused on the electronic transport properties of molecular devices consisting of the fullerene B 40 or B 40 with different anchor atoms between two gold electrodes in a two-probe configuration. The elements used as anchor atoms in the B 40 molecules were oxygen, selenium, and sulfur, i.e., chalcogens. The current characteristics of these fullerene-based molecular devices were calculated and analyzed. The analysis highlighted the superior electrical conductivity of the pure B 40 device compared to the devices based on its chalcogen-anchored variants. The conductivities of the molecular devices were ranked as follows: pure B 40  > selenium-anchored > sulfur-anchored > oxygen-anchored B 40 . It was also noted that the devices based on B 40 and its chalcogen-anchored variants gave nonzero conductance values at zero bias. These results pave the way for the application of these molecules in future nanodevices utilizing extremely small bias voltages.

  15. Forces due to surface water measured by force microscopy. Consequences for anchoring biological cells to surfaces

    International Nuclear Information System (INIS)

    Schilcher, K.

    1997-05-01

    Interaction forces in 'Scanning Force Microscopy' (SFM). Force curves revealed exponentially decaying, attractive forces between silicon tip and silicon sample in aqueous media. Replacing the silicon sample by a sheet of mica, the interaction forces had both, an attractive and a repulsive component. Addition of salts generally reduced the forces. At 500 mM salt concentration, the attractive force became quantized with a residual force value of 23 pN. The attractive force is attributed to the gain in energy of water molecules which are released from surface water into free water during tip-sample approach. This conclusion is supported by a statistical model. The repulsive force contribution in the case of mica, is caused by hydration forces due to the spatial organization of crystalline water on the mica surface. Anchoring of biological cells. Molecular resolution of cell surfaces by SFM requires cell anchoring without interference with cell physiology. For this a novel strategy, 'hydrophobic anchoring' was designed. It avoids strong attractive forces between cell and by using a flexible spacer molecule. It establishes anchoring by a lipid (bound to the spacer), which weakly interacts with the hydrophobic core of the cell membrane. The method was subjected to tests using RBL-2H3, CH0 αβ and HEK-293 cells. The strength of cell anchoring was assayed by shear forces. In all cases 'hydrophobic anchoring' via a spacer caused elective anchoring much beyond controls. Such cell anchoring was employed for the imaging of RBL-2H3 cells by SFM. Images showed considerable finer details than images of loosely adsorbed cells. With about 50 rim resolution, SFM succeeded in imaging microvilli, filopodia, single cytoskeletal fibers (microtubules, microfilaments) and vesicles. In addition, as a consequence of cell stimulation upon ionomycin treatment, lamellae formation and the appearance of secretory granules on top of them were observed which indicates the viability of anchored

  16. Iron anchors of Northern Odisha, east coast India: Maritime contacts with European countries

    Digital Repository Service at National Institute of Oceanography (India)

    Tripati, S.; Patnaik, S.K.; Acharya, S.B.

    and agricultural products (Habib 1982: 49– 6    52). As iron was in abundance in the Nilgiri hills region, the area may have been the source for the raw materials in the manufacture of these anchors. Ascertaining the owners of these anchors is difficult because...th century lexicon, Bahar-i Ajam, describes a langar made of iron used to stop vessels from moving away (Qaisar 1982: 27). In the second half of the 17th century, attempts were made to manufacture iron anchors in India and a breakthrough...

  17. 'Saurashtra stone anchors' (Ring-stones) from Dwarka and Somnath, west coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Gaur, A.S.; Sundaresh; Tripati, S.; Gudigar, P.; Bandodkar, S.N.

    , semi-curved top with an axial hole; diameter of the hole is same at both ends. Often the chisel marks have been noticed on the surface and in the hole. The 'Saurashtra Stone Anchors' (Ring-stones) Dwarka and Somnath 133 average estimated weight... chisel marks have also been noticed on some of the anchors. The average weight of this group is 98 kg. The heaviest anchor (no. 8) weighs 205 kg and the lightest (no. 14) 64 kg. Group III: Ring-stone numbers 1, 6, 11, 18 and 22 fall in this last...

  18. Extrusion of bone anchor suture following flexor digitorum profundus tendon avulsion injury repair.

    LENUS (Irish Health Repository)

    Tiong, William H C

    2011-09-01

    Flexor digitorum profundus (FDP) zone I tendon avulsion injury is traditionally repaired with a pullout suture technique. More recently, bone anchor sutures have been used as a viable alternative and have largely replaced areas in hand surgery where pullout suture technique was once required. To date, there have been very few complications reported related to bone anchor suture use in FDP tendon reattachment to the bone. We report a very unusual case of extrusion of bone anchor through the nailbed, 6 years after zone I FDP tendon avulsion injury repair and a brief review of literature.

  19. Biomechanical analysis of pullout strengths of rotator cuff and glenoid anchors: 2011 update.

    Science.gov (United States)

    Barber, F Alan; Herbert, Morley A; Hapa, Onur; Rapley, Jay H; Barber, Cameron A K; Bynum, James A; Hrnack, Scott A

    2011-07-01

    To evaluate the biomechanical and design characteristics of newer suture anchors. Suture anchors were tested in fresh porcine metaphyseal cortex and cancellous troughs by use of an established protocol. A mechanical testing machine applied tensile loads parallel to the axis of insertion at 12.5 mm/s until failure, and mean anchor failure strengths were calculated. The mode of failure was recorded. Rotator cuff anchors tested included the Doubleplay and Opus SpeedScrew (ArthroCare Sports Medicine, Sunnyvale, CA); PEEK Intraline and PEEK Zip (Stryker, San Jose, CA); Paladin, SuperRevo FT, and CrossFT (ConMed Linvatec, Largo, FL); Piton (Tornier, Warsaw, IN); Ti Screw, ALLthread PEEK, LactoScrew, ALLthread Ti, and ALLthread PEEK knotless (Biomet Sports Medicine, Warsaw, IN). Glenoid anchors included the Gryphon BR P (DePuy-Mitek, Raynham, MA) and JuggerKnot 1.4 (Biomet Sports Medicine). Mean cortical failure loads for cuff anchors were as follows: Doubleplay 5.0, 279 N; Doubleplay 6.5, 338 N; Opus SpeedScrew 5.5, 356 N; Opus SpeedScrew 6.5, 336 N; PEEK Intraline 5.5, 263 N; PEEK Intraline 6.5, 344 N; PEEK Zip 5.5, 435 N; PEEK Zip 6.5, 502 N; Paladin 5.0, 500 N; Paladin 6.5, 521 N; SuperRevo FT, 496 N; CrossFT, 569 N; Piton, 379 N; Ti Screw 5.0, 457 N; Ti Screw 6.5, 443 N; ALLthread PEEK 5.5, 476 N; LactoScrew 5.5, 403 N; ALLthread Ti 5.0, 526 N; ALLthread Ti 6.5, 653 N; and ALLthread PEEK knotless, 441 N). Mean cortical failure loads for glenoid anchors were 161 N for Gryphon BR P and 239 N for JuggerKnot 1.4. Mean cancellous bone failure loads for cuff anchors were Doubleplay 5.0, 263 N; Doubleplay 6.5, 340 N; Opus SpeedScrew 5.5, 356 N; Opus SpeedScrew 6.5, 344 N; PEEK Intraline 5.5, 274 N; PEEK Intraline 6.5, 327 N; PEEK Zip 5.5, 401 N; PEEK Zip 6.5, 396 N; Paladin 5.0, 427 N; Paladin 6.5, 491 N; SuperRevo FT, 483 N; CrossFT, 547 N; Piton, 365 N; Ti Screw 5.0, 420 N; Ti Screw 6.5, 448 N; ALLthread PEEK 5.5, 475 N; LactoScrew 5.5, 435 N; ALLthread Ti 5.0, 512 N

  20. Leukocyte adhesion and polarization: Role of glycosylphosphatidylinositol-anchored proteins.

    Science.gov (United States)

    Richardson, Dion D; Fernandez-Borja, Mar

    2015-01-01

    Leukocyte traffic out of the blood stream is crucial for an adequate immune response. Leukocyte extravasation is critically dependent on the binding of leukocyte integrins to their endothelial counterreceptors. This interaction enables the firm adhesion of leukocytes to the luminal side of the vascular wall and allows for leukocyte polarization, crawling and diapedesis. Leukocyte adhesion, polarization and migration requires the orchestrated regulation of integrin adhesion/de-adhesion dynamics and actin cytoskeleton rearrangements. Adhesion strength depends on conformational changes of integrin molecules (affinity) as well as the number of integrin molecules engaged at adhesion sites (valency). These two processes can be independently regulated and several molecules modulate either one or both processes. Cholesterol-rich membrane domains (lipid rafts) participate in integrin regulation and play an important role in leukocyte adhesion, polarization and motility. In particular, lipid raft-resident glycosyl-phosphatidyl-inositol-anchored proteins (GPI-APs) have been reported to regulate leukocyte adhesion, polarization and motility in both integrin-dependent and independent manners. Here, we present our recent discovery concerning the novel role of the GPI-AP prion protein (PrP) in the regulation of β1 integrin-mediated monocyte adhesion, migration and shape polarization in the context of existing literature on GPI-AP-dependent regulation of integrins.

  1. Gold nanoparticles assembled with dithiocarbamate-anchored molecular wires

    Science.gov (United States)

    Reeler, Nini E. A.; Lerstrup, Knud A.; Somerville, Walter; Speder, Jozsef; Petersen, Søren V.; Laursen, Bo W.; Arenz, Matthias; Qiu, Xiaohui; Vosch, Tom; Nørgaard, Kasper

    2015-01-01

    A protocol for the bottom-up self-assembly of nanogaps is developed through molecular linking of gold nanoparticles (AuNPs). Two π-conjugated oligo(phenylene ethynylene) molecules (OPE) with dithiocarbamate anchoring groups are used as ligands for the AuNPs. OPE-4S with a dithiocarbamate in each end of the molecule and a reference molecule OPE-2S with only a single dithiocarbamate end group. The linking mechanism of OPE-4S is investigated by using a combination of TEM, UV-Vis absorption and surface enhanced Raman spectroscopy (SERS) as well as studying the effect of varying the OPE-4S to AuNP concentration ratio. UV-Vis absorption confirms the formation of AuNP aggregates by the appearance of an extended plasmon band (EPB) for which the red shift and intensity depend on the OPE-4S:AuNP ratio. SERS confirms the presence of OPE-4S and shows a gradual increase of the signal intensity with increasing OPE-4S:AuNP ratios up to a ratio of about 4000, after which the SERS intensity does not increase significantly. For OPE-2S, no linking is observed below full coverage of the AuNPs indicating that the observed aggregate formation at high OPE-2S:AuNP ratios, above full AuNP coverage, is most likely of a physical nature (van der Waals forces or π-π interactions). PMID:26471461

  2. Collagenous microstructure of the glenoid labrum and biceps anchor.

    Science.gov (United States)

    Hill, A M; Hoerning, E J; Brook, K; Smith, C D; Moss, J; Ryder, T; Wallace, A L; Bull, A M J

    2008-06-01

    The glenoid labrum is a significant passive stabilizer of the shoulder joint. However, its microstructural form remains largely unappreciated, particularly in the context of its variety of functions. The focus of labral microscopy has often been histology and, as such, there is very little appreciation of collagen composition and arrangement of the labrum, and hence the micromechanics of the structure. On transmission electron microscopy, significant differences in diameter, area and perimeter were noted in the two gross histological groups of collagen fibril visualized; this suggests a heterogeneous collagenous composition with potentially distinct mechanical function. Scanning electron microscopy demonstrated three distinct zones of interest: a superficial mesh, a dense circumferential braided core potentially able to accommodate hoop stresses, and a loosely packed peri-core zone. Confocal microscopy revealed an articular surface fine fibrillar mesh potentially able to reduce surface friction, bundles of circumferential encapsulated fibres in the bulk of the tissue, and bone anchoring fibres at the osseous interface. Varying microstructure throughout the depth of the labrum suggests a role in accommodating different types of loading. An understanding of the labral microstructure can lead to development of hypotheses based upon an appreciation of this component of material property. This may aid an educated approach to surgical timing and repair.

  3. High performance supercapacitors using metal oxide anchored graphene nanosheet electrodes

    KAUST Repository

    Baby, Rakhi Raghavan

    2011-01-01

    Metal oxide nanoparticles were chemically anchored onto graphene nanosheets (GNs) and the resultant composites - SnO2/GNs, MnO2/GNs and RuO2/GNs (58% of GNs loading) - coated over conductive carbon fabric substrates were successfully used as supercapacitor electrodes. The results showed that the incorporation of metal oxide nanoparticles improved the capacitive performance of GNs due to a combination of the effect of spacers and redox reactions. The specific capacitance values (with respect to the composite mass) obtained for SnO2/GNs (195 F g-1) and RuO 2/GNs (365 F g-1) composites at a scan rate of 20 mV s-1 in the present study are the best ones reported to date for a two electrode configuration. The resultant supercapacitors also exhibited high values for maximum energy (27.6, 33.1 and 50.6 W h kg-1) and power densities (15.9, 20.4 and 31.2 kW kg-1) for SnO2/GNs, MnO2/GNs and RuO2/GNs respectively. These findings demonstrate the importance and great potential of metal oxide/GNs based composite coated carbon fabric in the development of high-performance energy-storage systems. © 2011 The Royal Society of Chemistry.

  4. Development of a prediction system for tail-anchored proteins.

    Science.gov (United States)

    Shigemitsu, Shunsuke; Cao, Wei; Terada, Tohru; Shimizu, Kentaro

    2016-09-15

    "Tail-anchored (TA) proteins" is a collective term for transmembrane proteins with a C-terminal transmembrane domain (TMD) and without an N-terminal signal sequence. TA proteins account for approximately 3-5 % of all transmembrane proteins that mediate membrane fusion, regulation of apoptosis, and vesicular transport. The combined use of TMD and signal sequence prediction tools is typically required to predict TA proteins. Here we developed a prediction system named TAPPM that predicted TA proteins solely from target amino acid sequences according to the knowledge of the sequence features of TMDs and the peripheral regions of TA proteins. Manually curated TA proteins were collected from published literature. We constructed hidden markov models of TA proteins as well as three different types of transmembrane proteins with similar structures and compared their likelihoods as TA proteins. Using the HMM models, we achieved high prediction accuracy; area under the receiver operator curve values reaching 0.963. A command line tool written in Python is available at https://github.com/davecao/tappm_cli .

  5. The bone-anchored hearing aid for children: recent developments.

    Science.gov (United States)

    Snik, Ad; Leijendeckers, Joop; Hol, Myrthe; Mylanus, Emmanuel; Cremers, Cor

    2008-09-01

    In 1984 the Bone-Anchored Hearing Aid, or BAHA, system was introduced. Its transducer is coupled directly to the skull percutaneously to form a highly effective bone-conduction hearing device. Clinical studies on adults with conductive hearing loss have shown that the BAHA system outperforms conventional bone-conduction hearing aids. Therefore, the next step was to apply the BAHA system in children with congenital or acquired conductive hearing loss. Reviewed data showed that, on average, such children benefited significantly more from the BAHA than from reconstructive surgery. Thus, BAHA application appears to be the best option to achieve normal communication and speech and language development in children with bilateral conductive hearing loss. However, in children under the age of three to four years, a conventional solution must be applied, e.g. a bone conductor with a transcutaneous coupling, because they are too young to undergo BAHA implant surgery. In the case of unilateral congenital conductive hearing loss, there is no convincing evidence in the clinical literature for early intervention. In summary, the BAHA system can be considered a new, indispensable tool for children with bilateral conductive hearing loss.

  6. Clinical experience of bone anchored hearing aid: a case report.

    Science.gov (United States)

    Miyasaka, Muneo; Akamatsu, Tadashi; Yamazaki, Akihisa; Tanaka, Rica

    2008-04-20

    To improve conventional bone conduction hearing aids, Tjellstrom, Branemark, developed an implant system consisting of a maxillofacial implant that derived from dental implants and a bone conduction hearing aid that was attached directly to the implant. This system has been commercially available as a bone anchored hearing aid (BAHA). More than 10,000 patients have benefited from BAHA in Scandinavia, North America, and many other regions. BAHA first became available in 1977 in Sweden but has not been used in Japan as widely as expected. This paper reports a case of a 8-year use of BAHA for hearing loss caused by microtia and external auditory canal atresia, with a review of literature. The patient has been followed up for 9 years after implant placement. Play audiometry with a loudspeaker showed a hearing loss of 25 dB. The patient says that BAHA is superior to conventional transcutaneous bone conduction hearing aids in easiness of attachment, esthetics, and speech recognition and music recognition. The skin and the bone around the implants remain in favorable condition. She has been free from the use of a headband for a conventional hearing aid.

  7. Surgery for the bone-anchored hearing aid.

    Science.gov (United States)

    Arnold, Andreas; Caversaccio, Marco-Domenico; Mudry, Albert

    2011-01-01

    This review covers the surgery for the bone-anchored hearing aid (Baha(®)). PREOPERATIVE WORKUP: A review of the indications and preoperative diagnostics shows that best results are generally obtained in patients with conductive or mixed hearing loss rehabilitation when surgery is not applicable or has failed and in patients that suffer from single-sided deafness. An audiogram must confirm that the bone conduction hearing is within the inclusion criteria. A computed tomography scan is performed in cases of malformation to assure sufficient bone thickness at the site of screw implantation. The steps of the Baha implantation are described step by step including the setting and anesthesia, skin work with regard to different techniques, correct resection of subcutaneous tissue, preparation of the implant site, drilling and placement of the fixture and wound closure. After wound healing (6-8 weeks), the bone conduction aid is fitted on the abutment. Regular cleaning of the fixture is important to avoid irritations and infections. If performed carefully, the surgery for the Baha has a favorable outcome, regardless of the technique used. Copyright © 2011 S. Karger AG, Basel.

  8. [Clinical application of bone-anchored hearing aid implantation].

    Science.gov (United States)

    Xia, Yin; Zhang, Hua; Gong, Shu-sheng; Wang, Dan-ni; Zheng, Ya-li; Li, Yu-ling; Dong, Bo-ya; Han, De-min

    2013-08-01

    To discuss the indications, surgery methods and effects of the BAHA implantation by analyzing the patients' medical records of bone-anchored hearing aids(BAHA). Retrospective analyzed the records of 16 patients of BAHA implantation, including nine males and seven females. Their average age was 31 years old (8-53ys). Nine of them were congenital ear malformation, two were chronic suppurative otitis media, two were otosclerosis and three were unilateral severe sensorineural deafness. We evaluated their pure tone audiometry (PTA), speech audiometry and temporal CT before the surgery, and evaluated the aided PTA in soundfield and speech audiometry in sound field. These patients received BAHA implantation and installed the speech processor their months later. The average preoperative PTA measurements (PTA at 0.5, 1, 2, 4 kHz) was (63.2 ± 19.0) dB HL and postoperative aided PTA in sound field was (35.5 ± 10.9)dB HL. The average improvement in Hearing In Noise Test (HINT) was 37.0% ± 31.7%. The average improvement in Mandarin Speech Test was 76.0% ± 19.7%. After 4-16 months' follow-up, no significant complications were recorded. BAHA is a safe and effective bone implantable hearing device.

  9. Bone-anchored hearing device placement with translabyrinthine tumor removal.

    Science.gov (United States)

    McRackan, Theodore R; Goddard, John C; Wilkinson, Eric P; Slattery, William H; Brackmann, Derald E

    2015-02-01

    Translabyrinthine resection of intracranial tumors results in single-sided deafness, which can be treated by surgical and nonsurgical means. Here we describe the first series examining complication and device usage rates among patients receiving a surgically implanted bone-anchored hearing device (BAHD) at the time of translabyrinthine tumor removal. Case series with chart review. Private tertiary neurotologic referral center. Patients (N = 154) undergoing concurrent BAHD placement and translabyrinthine tumor resection. Concurrent BAHD placement and translabyrinthine tumor removal. Postoperative complication rates and BAHD usage. Of the 154 patients, 121 (78.6%) had no device-related complications. The most common device-related complications were skin overgrowth (8.4%), acute infection (5.2%), and chronic infection (3.2%). The overall and specific complication rates did not differ from published BAHD complication rates. One patient (0.6%) developed a cerebrospinal leak through the surgical site for the device. At the time of last follow-up (mean, 39.8 months), 151 patients (95.0%) were still using their devices. Patients undergoing concurrent translabyrinthine tumor removal and BAHD placement exhibit similar device-related complication profiles as patients undergoing standard device placement. Based on these outcomes and the high long-term usage rates, BAHD insertion at the time of translabyrinthine intracranial surgery can be considered a safe and useful procedure. © American Academy of Otolaryngology—Head and Neck Surgery Foundation 2014.

  10. Enhancement of polar anchoring strength in a graphene-nematic suspension and its effect on nematic electro-optic switching

    Science.gov (United States)

    Basu, Rajratan

    2017-07-01

    A small quantity of monolayer graphene flakes is doped in a nematic liquid crystal (LC), and the effective polar anchoring strength coefficient between the LC and the alignment substrate is found to increase by an order of magnitude. The hexagonal pattern of graphene can interact with the LC's benzene rings via π -π electron stacking, enabling the LC to anchor to the graphene surface homogeneously (i.e., planar anchoring). When the LC cell is filled with the graphene-doped LC, some graphene flakes are preferentially attached to the alignment layer and modify the substrate's anchoring property. These spontaneously deposited graphene flakes promote planar anchoring at the substrate and the polar anchoring energy at alignment layer is enhanced significantly. The enhanced anchoring energy is found to impact favorably on the electro-optic response of the LC. Additional studies reveal that the nematic electro-optic switching is significantly faster in the LC-graphene hybrid than that of the pure LC.

  11. MAIL1 is essential for development of the primary root but not of anchor roots.

    Science.gov (United States)

    Ühlken, Christine; Hoth, Stefan; Weingartner, Magdalena

    2014-01-01

    MAIN-LIKE1 (MAIL1) is a ubiquitously expressed nuclear protein, which has a crucial function during root development. We have recently described loss of function mutants for MAIL1, in which the organization and function of the primary root meristem is lost soon after germination. Moreover cell differentiation is impaired resulting in primary root growth arrest soon after emergence. Here we show that mail1 mutants form several anchor roots from the hypocotyl to root junction. These anchor roots show similar defects in the organization of the stem cell niche as the primary root. In contrast, differentiation processes are not impaired and thus anchor roots seem to be able to compensate for the loss of primary root function. Our data show that MAIL1 is essential for specification of cell fate in the primary root but not in anchor roots.

  12. 48 CFR 225.7007 - Restrictions on anchor and mooring chain.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Restrictions on anchor and mooring chain. 225.7007 Section 225.7007 Federal Acquisition Regulations System DEFENSE ACQUISITION... mooring chain. ...

  13. Investigation into the behaviour of concrete anchored diaphragm walls under earthquake condition

    International Nuclear Information System (INIS)

    Saba, H. R.; Rahaii, A. R.

    2003-01-01

    Diaphragm walls are frequently used in civil Engineering projects. Considering the variety and important volume of consumed materials (concrete, anchors and soil), one of the important factors for design and construction of these walls, are their behaviour under different executive, and loading conditions. In this paper, various models of concrete diaphragms with different number of anchors and soil parameters under static and dynamic loading have been investigated using finite element method with nonlinear models. Results including the internal forces in diaphragm walls, variation of forces in the anchors, shape of the sliding surface and variation of pressure in soil are obtained and compared. An experimental tool with suitable measurement systems for determining the pressure and internal forces was designed and realised. Also with similitude and dimensional analyses, diaphragms with different number of anchors were built and set on the shaking table test and experimented under different accelograms. Finally results of nonlinear dynamic analysis were compared with experimental results

  14. Suture slippage in knotless suture anchors resulting in subacromial-subdeltoid bursitis.

    Science.gov (United States)

    Hayeri, Mohammad Reza; Keefe, Daniel T; Chang, Eric Y

    2016-05-01

    Rotator cuff repair using a suture bridge and knotless suture anchors is a relatively new, but increasingly used technique. The suture bridge technique creates an anatomically similar and more secure rotator cuff repair compared with conventional arthroscopic techniques and the use of knotless anchors eliminates the challenges associated with knot tying during arthroscopic surgery. However, previous in vitro biomechanical tests have shown that the hold of the suture in a knotless suture anchor is far lower than the pullout strength of the anchor from bone. Up until now slippage has been a theoretical concern. We present a prospectively diagnosed case of in vivo suture loosening after rotator cuff repair using a knotless bridge technique resulting in subacromial-subdeltoid bursitis.

  15. Retractable Robotic Anchor for Hard Rock and Granular Soils, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — ProtoInnovations proposes to research, develop, and validate an innovative retractable robotic anchoring mechanism that works both in hard rock and granular soils...

  16. Inflation targeting and the anchoring of inflation expectations in the CEE countries

    Directory of Open Access Journals (Sweden)

    Nedeljković Milan

    2017-01-01

    Full Text Available This paper studies the time evolution in the degree and level of anchoring of inflation expectations in four Central and Eastern European inflation targeting countries. The results suggest that the degree of anchoring of inflation expectations increased gradually in all countries over the last decade, while the level of implied inflation targets moved towards the official target. The extent of anchoring increased more strongly in the first years following the IT adoption and more gradually over the later period. We also find that smooth changes of the official target had a positive impact on anchoring. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. 47028: Advancing Serbia’s Competitiveness in the Process of EU Accession

  17. The stability and functional properties of proteoliposomes mixed with dextran derivatives bearing hydrophobic anchor groups

    NARCIS (Netherlands)

    Elferink, Marieke G.L.; Wit, Janny G. de; Veld, Gerda in 't; Reichert, Anke; Driessen, Arnold J.M.; Ringsdorf, Helmut; Konings, Wilhelmus

    1992-01-01

    Liposomes composed of Escherichia coli phospholipid were coated with polysaccharides bearing hydrophobic palmitoyl anchors. The effect on the stability of liposomes without or with integral membrane proteins was investigated. A high concentration of hydrophobized dextrans protected the liposomes

  18. Mechanical Analysis of Stress Distribution in a Carbon Fiber-Reinforced Polymer Rod Bonding Anchor

    Directory of Open Access Journals (Sweden)

    Peng Feng

    2014-04-01

    Full Text Available This paper presents an elastic shear stress distribution theoretical model at the carbon fiber-reinforced polymer (CFRP-adhesive interface of a single-rod and a multi-rod straight-pipe bonding anchor. A comparison between theoretical and finite element analysis results reveals that the accuracy of the theory can be used to guide the preliminary design of CFRP rod bonding anchors. The mechanical performance of the inner cone bonding anchor for multi-rods are evaluated within different coefficients of friction and inner inclined angles. Numerical results indicate that the straight-parabolic inner cone bonding anchor has a significant effect on reducing the shear force at the loading end.

  19. Two novel self-assemblies of supramolecular solar cells using N-heterocyclic-anchoring porphyrins

    Science.gov (United States)

    Zhang, Qian; Wu, Fang-Yuan; Liu, Jia-Cheng; Li, Ren-Zhi; Jin, Neng-Zhi

    2018-02-01

    Two novel N-substituted anchoring porphyrins (ZnPAtz and ZnPAim) have been devised and synthesized. Moreover, these two anchoring porphyrins were linked to the TiO2 semiconductor through carboxyl groups and then a zinc porphyrin ZnP was bound to the anchoring porphyrin using a zinc-to-ligand axial coordination approach. The different performances of these assemblies were compared with single anchoring porphyrin devices ZnPAtz and ZnPAim. The photoelectric conversion efficiency of the new supramolecular solar cells sensitized by ZnP-ZnPAx (x = tz, im) has been improved. The ZnP-ZnPAtz-based DSSCs provided the highest photovoltaic efficiency (1.86%). Fundamental studies showed that incorporation of these assemblies promote light-harvesting efficiency.

  20. Effects of an Anchoring Configuration on the Static Response of Geotextile and Geogrid Fabrics

    National Research Council Canada - National Science Library

    Simmons, Lebron

    2000-01-01

    An investigation is made of a potential retrofit system for in-fill masonry walls subjected to blast effects that consist of geotextile or geogrid materials anchored to the roof, floor slabs and beams...

  1. Stone anchors from Bet Dwarka Island, Gujarat, Coast, India: Significance to historical period maritime activities

    Digital Repository Service at National Institute of Oceanography (India)

    Sundaresh; Gaur, A.S.; Tripati, S.; Gudigar, P.; Bandodkar, S.N.

    Bet Dwarka Island is situated on the extreme west of Indian territory in Jamnagar district of Gujarat. Underwater, the most preserved remains of ancient maritime activity could be the stone anchors of different types, as every boat requires...

  2. Benefit and quality of life in older bone-anchored hearing aid users.

    NARCIS (Netherlands)

    Wolf, M.J.F. de; Shival, M.L.; Hol, M.K.S.; Mylanus, E.A.M.; Cremers, C.W.R.J.; Snik, A.F.M.

    2010-01-01

    OBJECTIVE: Benefit and quality-of-life analysis in the older adult bone-anchored hearing aid (BAHA) users. STUDY DESIGN: Retrospective evaluation. METHODS: Four questionnaires (Glasgow Benefit Inventory, Abbreviated Profile of Hearing Aid Benefit [APHAB], Nijmegen Cochlear Implant Questionnaire

  3. HSV1 MicroRNA Modulation of GPI Anchoring and Downstream Immune Evasion

    Directory of Open Access Journals (Sweden)

    Jonatan Enk

    2016-10-01

    Full Text Available Herpes simplex virus 1 (HSV1 is a ubiquitous human pathogen that utilizes variable mechanisms to evade immune surveillance. The glycosylphosphatidylinositol (GPI anchoring pathway is a multistep process in which a myriad of different proteins are covalently attached to a GPI moiety to be presented on the cell surface. Among the different GPI-anchored proteins there are many with immunological importance. We present evidence that the HSV1-encoded miR H8 directly targets PIGT, a member of the protein complex that covalently attaches proteins to GPI in the final step of GPI anchoring. This results in a membrane down-modulation of several different immune-related, GPI-anchored proteins, including ligands for natural killer-activating receptors and the prominent viral restriction factor tetherin. Thus, we suggest that by utilizing just one of dozens of miRNAs encoded by HSV1, the virus can counteract the host immune response at several key points.

  4. Archaeometallurgical investigation of the iron anchor from the Tantura F shipwreck

    Energy Technology Data Exchange (ETDEWEB)

    Aronson, A. [Faculty of Engineering, Tel Aviv University, Ramat Aviv 69978 (Israel); Ashkenazi, D., E-mail: dana@eng.tau.ac.il [Faculty of Engineering, Tel Aviv University, Ramat Aviv 69978 (Israel); Barkai, O.; Kahanov, Y. [Leon Recanati Institute for Maritime Studies, University of Haifa, Haifa 31905 (Israel)

    2013-04-15

    The Tantura F shipwreck was a coaster or a fishing vessel about 15.7 m long, discovered in the Dor/Tantura lagoon, Israel in 1995. It was dated to between the mid-7th and the end of the 8th centuries CE. Among the finds excavated were two T-shaped type iron anchors. Of the two anchors, one (anchor A) was thoroughly studied by archaeometallurgical methods in order to identify forge-welding lines, to determine the welding quality and to understand the manufacturing technology. The examinations included X-ray radiography, XRF analysis, optical microscopy, SEM/EDS observation and analysis, OES analysis and microhardness tests. The investigation included characterization of the composition, microstructure, thermal treatments, forge-welding junctions and slag analysis. The results revealed a heterogeneous microstructure, rich in glassy, fayalite and wüstite slag. Iron based phases included ferrite, pearlite, cementite and Widmanstätten plates, all typical to wrought iron. The forge-welds of Anchor A were located. Each arm was made of one piece, weighing about 2.5–3 kg and the shank was made of a few 1.5–2 kg pieces. The second anchor (anchor B) was only briefly examined visually and with a few radiographs, which support the results from anchor A. The research results revealed significant information about T-shaped anchors and their manufacturing process, including hot-working processes without any additional heat treatments, and folding techniques. The microstructure was similar to other ancient simple tools such as saws, sickles, axes and mortise chisels, and though the technology to make complicated structures and objects, such as swords, existed at that time, the anchors did not require this sophistication; thus simpler techniques were used, presumably because they were more cost-effective. - Highlights: ► Tantura F was a coaster dated to mid-7th–end-8th centuries. ► Two iron anchors were discovered at the Tantura F shipwreck-site. ► Anchor A was

  5. MAIL1 is essential for development of the primary root but not of anchor roots

    OpenAIRE

    Ühlken, Christine; Hoth, Stefan; Weingartner, Magdalena

    2014-01-01

    MAIN-LIKE1 (MAIL1) is a ubiquitously expressed nuclear protein, which has a crucial function during root development. We have recently described loss of function mutants for MAIL1, in which the organization and function of the primary root meristem is lost soon after germination. Moreover cell differentiation is impaired resulting in primary root growth arrest soon after emergence. Here we show that mail1 mutants form several anchor roots from the hypocotyl to root junction. These anchor root...

  6. Development of a New Nondestructive Inspection Strategy for Corroded Multistrand Anchor Cables

    Science.gov (United States)

    2016-07-01

    parking structures , rock and soil anchors, houses, and many other structures . Figure 1 (left) and (middle) show a typical cable and multistrand anchor...generally only one end of the cable is accessible. Additionally with navigation structures , the cable’s path is most often deep within the concrete, and... cables in navigational structures is to be achieved. INITIAL GUIDED WAVE INVESTIGATIONS: In the 2012 Federal Highway Works Administration report

  7. Material and welding development of anchor plates to build nuclear power plant by blue arc process

    International Nuclear Information System (INIS)

    Gibelli, C.E.

    1986-01-01

    To build nuclear power plants, anchor plates are plenty used. These anchor plates serve as a system with the purpose to fix many heavy components or a simple stair. Considering the necessity of element fabrication fastly, with reasonable economy and quality, the arc study welding process (blue arc) was used. A special development of the material concept as well as a welding procedure and a subsuppliers qualification of the raw material was necessary. (Author) [pt

  8. The affordance of anchored discussion for the collaborative processing of academic texts.

    OpenAIRE

    van der Pol, Jakko; Admiraal, W.; Simons, P.R.J.

    2006-01-01

    A system for ‘anchored discussion’ is compared with a system for traditional forum discussion (Blackboard), and their affordances for the collaborative processing of academic texts are investigated. Results show that discussion in the system for anchored discussion is directed at a processing of the meaning of the texts to a larger extent than discussion in the traditional forum, which is more oriented towards the sharing of personal opinions and experiences. This difference in orientation pr...

  9. Exploring body-anchored and experience-based learning in a community of practice

    DEFF Research Database (Denmark)

    Stelter, Reinhard

    2008-01-01

    The article aims to integrate body-anchored and experience-based learning in the theoretical concept of learning in a community of practice. Present moment, epoché, intentional orientation and meaning making are introduced as the four basic premises for body-anchored and experience-based learning...... as the outflow of speech acts, originally based on embodied and experience-based knowledge....

  10. Dynamic behaviour of anchors in cracked and uncracked concrete: a progress report

    International Nuclear Information System (INIS)

    Rodriguez, M.; Klingner, R.E.

    1997-01-01

    In early 1993, the US Nuclear Regulatory Commission began a research program at The University of Texas at Austin, dealing with the dynamic behavior of anchors in cracked and uncracked concrete. In this paper, the progress of that research program is reviewed. The test program is summarized, and work performed to date is reviewed, with emphasis on the dynamic and static behavior of single tensile anchors in uncracked concrete. General conclusions from that work are discussed, and future plans are presented. (orig.)

  11. Molecular beacon anchored onto a graphene oxide substrate

    Science.gov (United States)

    Darbandi, Arash; Datta, Debopam; Patel, Krunal; Lin, Gary; Stroscio, Michael A.; Dutta, Mitra

    2017-09-01

    In this article, we report a graphene oxide-based nanosensor incorporating semiconductor quantum dots linked to DNA-aptamers that functions as a ‘turn-off’ fluorescent nanosensor for detection of low concentrations of analytes. A specific demonstration of this turn-off aptasensor is presented for the case of the detection of mercury (II) ions. In this system, ensembles of aptamer-based quantum-dot sensors are anchored onto graphene oxide (GO) flakes which provide a platform for analyte detection in the vicinity of GO. Herein, the operation of this ensemble-based nanosensor is demonstrated for mercury ions, which upon addition of mercury, quenching of the emission intensity from the quantum dots is observed due to resonance energy transfer between quantum dots and the gold nanoparticle connected via a mercury target aptamer. A key result is that the usually dominant effect of quenching of the quantum dot due to close proximity to the GO can be reduced to negligible levels by using a linker molecule in conjunctions with the aptamer-based nanosensor. The effect of ionic concentration of the background matrix on the emission intensity was also investigated. The sensor system is found to be highly selective towards mercury and exhibits a linear behavior (r 2 > 0.99) in the nanomolar concentration range. The detection limit of the sensor towards mercury with no GO present was found to be 16.5 nM. With GO attached to molecular beacon via 14 base, 35 base, and 51 base long linker DNA, the detection limit was found to be 38.4 nM, 9.45 nM, and 11.38 nM; respectively.

  12. Study on interaction between soil and anchor chain with finite element method

    Science.gov (United States)

    Li, Sa; Xu, Bao-zhao; Wu, Yun-zhou; Li, Zhong-gang

    2016-12-01

    With the development of offshore engineering, deeply embedded anchors are needed to be penetrated to appreciable depth and attached at the pad-eye. The interaction between anchor chain and soil is a very complex process and has not been thoroughly understood yet. In this paper, the finite element method (FEM) was used to study the interaction of soil-chain system. Results of the analysis show that when the attachment point is at a shallow depth, the load-development characteristics of the chain from FEM are in good agreement with that from the model tests and theoretical analysis. But with the depth increment, the results are different obviously in different methods. This phenomenon is resulted from a variety of reasons, and the plastic zone around the chain was studied to try finding the mechanism behind it. It could be seen that the plastic zone extended in different modes at different depths of attachment points. The interaction between the soil and anchor chain makes the load acting on the anchor decrease, but the soil disturbed surrounding the chain increases the anchor failure possibility. When the anchor bearing capacity is evaluated, these two factors should be considered properly at the same time.

  13. Stability Analysis of Anchored Soil Slope Based on Finite Element Limit Equilibrium Method

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    Rui Zhang

    2016-01-01

    Full Text Available Under the condition of the plane strain, finite element limit equilibrium method is used to study some key problems of stability analysis for anchored slope. The definition of safe factor in slices method is generalized into FEM. The “true” stress field in the whole structure can be obtained by elastic-plastic finite element analysis. Then, the optimal search for the most dangerous sliding surface with Hooke-Jeeves optimized searching method is introduced. Three cases of stability analysis of natural slope, anchored slope with seepage, and excavation anchored slope are conducted. The differences in safety factor quantity, shape and location of slip surface, anchoring effect among slices method, finite element strength reduction method (SRM, and finite element limit equilibrium method are comparatively analyzed. The results show that the safety factor given by the FEM is greater and the unfavorable slip surface is deeper than that by the slice method. The finite element limit equilibrium method has high calculation accuracy, and to some extent the slice method underestimates the effect of anchor, and the effect of anchor is overrated in the SRM.

  14. Implant survival rate in bone-anchored hearing aid users: long-term results.

    Science.gov (United States)

    Wallberg, E; Granström, G; Tjellström, A; Stalfors, J

    2011-11-01

    To investigate the long-term survival rate of bone-anchored hearing aid implants, and to assess the number of patients who stop using their bone-anchored hearing aid. Patients who underwent bone-anchored hearing aid surgery between September 1977 and December 1986 were identified from a prospective database. Data were collected from patient records. During the study period, 143 patients were fitted with a bone-anchored hearing aid. Records from 132 patients were found, with a mean follow up of nine years. A total of 150 implants were installed in these patients. A total of 41 implants (27 per cent) were lost during follow up: 17 lost osseointegration, 16 were removed and eight were lost due to direct trauma. At the end of follow up, 119/132 (90 per cent) patients were still using their bone-anchored hearing aid. Despite a high incidence of implant loss over time, a large number of patients still continued to use their bone-anchored hearing aid.

  15. Bone-anchored hearing aids in children and young adults: the Freeman Hospital experience.

    Science.gov (United States)

    Ramakrishnan, Y; Marley, S; Leese, D; Davison, T; Johnson, I J M

    2011-02-01

    To investigate the utilisation of bone-anchored hearing aids and Softband, as well as the effects on quality of life, amongst the paediatric and young adult population of Freeman Hospital, Newcastle Upon Tyne, UK. Retrospective, anonymised, cross-sectional survey using the Glasgow Benefit Inventory and Listening Situation Questionnaire (parent version), administered at least three months following the start of bone-anchored hearing aid or Softband use. One hundred and nine patients were included, of whom syndromic children made up a significant proportion (22 of 109). Patients using bone-anchored hearing aids obtained significant educational and social benefit from their aids. The mean Listening Situation Questionnaire difficulty score was 17 (15 patients), which is below the trigger score of 22+ at which further reassessment and rehabilitation is required. 87% (of 15 patients) did not require further intervention. The overall mean GBI score for the 22 patients (syndromic and non-syndromic) was +29. The use of bone-anchored hearing aids and Softband results in significant improvements in quality of life for children and young adults with hearing impairment. There is significant under-utilisation of bone-anchored hearing aids in children with skull and congenital abnormalities, and we would advocate bone-anchored hearing aid implantation for these patients.

  16. Quality of life improvement for bone-anchored hearing aid users and their partners.

    Science.gov (United States)

    McNeil, M L; Gulliver, M; Morris, D P; Bance, M

    2011-06-01

    Bone-anchored hearing aid recipients experience well documented improvements in their audiometric performance and quality of life. While hearing aid recipients may understate their functional improvement, their partners may be more aware of such improvement. We sought to investigate patients' partners' perceptions of functional improvement following bone-anchored hearing aid fitting. Surveys were sent to 153 patients who had received a bone-anchored hearing aid through the Nova Scotia bone-anchored hearing aid programme. The validated survey asked patients' partners to give their subjective impression of the bone-anchored hearing aid recipient's functional status. Surveys were completed by 90 patients (58.8 per cent), of whom 72 reported having a partner. Partners reported a significant improvement in hearing (p ≤ 0.0001). Partners reported improvement in 87.0 per cent of functional scenarios, no change in 12.6 per cent, and a decline in 0.4 per cent. These findings demonstrate a significant improvement in the emotional and social effects of hearing impairment, as perceived by bone-anchored hearing aid recipients' partners.

  17. Patient quality of life with bone-anchored hearing aid: 10-year experience in Glasgow, Scotland.

    Science.gov (United States)

    Mace, A T M; Isa, A; Cooke, L D

    2009-09-01

    This study aimed to ascertain the usefulness of the bone-anchored hearing aid and its impact on the quality of life of patients fitted in Glasgow between 1996 and 2006. The Entific Medical Systems questionnaire and the Glasgow Benefit Inventory were posted to patients in order to assess their satisfaction and quality of life changes. Sixty adult patients were identified, with a questionnaire response rate of 63 per cent. Thirty-two respondents (85 per cent) reported using their bone-anchored hearing aid for more than eight hours per day. Twenty-nine respondents (75 per cent) found their bone-anchored hearing aid to be generally better than their previous, conventional aid. Twenty-seven respondents (71 per cent) reported that their bone-anchored hearing aid improved their quality of life. The median total Glasgow Benefit Inventory score was +33.3. Bone-anchored hearing aid usage rates and satisfaction levels were high amongst patients in Glasgow. Glasgow Benefit Inventory indices were comparable to published findings from other centres. Despite this, bone-anchored hearing aid funding is still not universally available within the National Health Service in Scotland.

  18. Management of repeated trauma to bone-anchored hearing aids in a paediatric patient.

    Science.gov (United States)

    Shamil, E; Topsakal, V; Grolman, W

    2013-02-01

    To outline the management options and neurological complications associated with repeated traumatic falls that cause intrusion of bone-anchored hearing aid abutments. A three-year-old boy with coloboma, heart defects, atresia of nasal choanae, retarded growth, genital abnormalities, ear defects and deafness was fitted with a bone-anchored hearing aid for severe conductive hearing loss and congenital ear malformations. Six months later, a traumatic fall caused an intrusion injury which rendered the bone-anchored hearing aid abutment unusable. Without removing the original abutment, a second abutment was inserted on the same side to aid his hearing. Two years later, the child fell again and damaged his second bone-anchored hearing aid abutment. Having been offered a surgical option to repair the area, the parents opted to keep the abutments in situ. Direct trauma to the fixture of a bone-anchored hearing aid is a relatively common long-term complication in children which can disrupt osseointegration and disable the implant. For young children who are either prone to falling or have behavioural problems, a bone-anchored hearing aid Softband may be more appropriate to non-invasively aid hearing.

  19. Bioabsorbable Suture Anchor Migration to the Acromioclavicular Joint: How Far Can These Implants Go?

    Directory of Open Access Journals (Sweden)

    Giovanna Medina

    2014-01-01

    Full Text Available Few complications regarding the use of bioabsorbable suture anchors in the shoulder have been reported. What motivated this case report was the unusual location of the anchor, found in the acromioclavicular joint which, to our knowledge, has never been reported so far. A 53-year old male with previous rotator cuff (RC repair using bioabsorbable suture anchors presented with pain and weakness after 2 years of surgery. A suspicion of retear of the RC led to request of a magnetic resonance image, in which the implant was found located in the acromioclavicular joint. The complications reported with the use of metallic implants around the shoulder led to the development of bioabsorbable anchors. Advantages are their absorption over time, minimizing the risk of migration or interference with revision surgery, less artifacts with magnetic resonance imaging, and tendon-to-bone repair strength similar to metallic anchors. Since the use of bioabsorbable suture anchors is increasing, it is important to know the possible complications associated with these devices.

  20. A REVIEW OF THE DRIVE OPTIONS FOR OFFSHORE ANCHOR HANDLING WINCHES

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    Miguel Lamas Pardo

    2017-01-01

    Full Text Available This article discusses the state of the art for driving technologies of anchor handling winches for offshore operations. These systems are necessary for anchor handling operations associated with installation of many types of moored floating offshore structures. To perform these operations, it is necessary to use specialized vessels known as AHT (Anchor Handling Tug or AHTS (Anchor Handling Tug Supply vessel, which incorporate specific equipment such as towing winches, but with higher performance than conventional tugs both in size and in technical performance. There are nowadays two main options for driving the Anchor Handling/Towing winches: hydraulic with low or high pressure motors, and electrical with AC motors driven by Variable Frequency Drives. Additionally, a new technology is appearing in the industrial sector which is starting to be applied in the marine sector, and in some cases for anchor handing winches: the permanent magnet motor. The aim of this paper is to discuss these driving technologies and their importance in the future of this part of the marine sector.

  1. Optical monitoring of surface anchoring changes for nematic liquid crystal based chemical and biological sensors

    Science.gov (United States)

    Zou, Yang

    In this dissertation, optically monitoring the surface anchoring changes of liquid crystal (LC) due to the chemical or biological bindings is presented. The deformation of LC director with different anchoring energies is simulated using Finite Element Method and continuum theory of nematic LC. The optical properties of the LC film are simulated using the Finite Difference Time Domain method. First, the interference color method was used to monitor the anchoring change. The calculated and experimental interference colors of liquid crystal films due to the optical retardation of two orthogonal electromagnetic components at different surface anchoring conditions and applied voltages are studied. The calculated colors were converted into sRGB parameters so that the corresponding colors can be displayed on a color computer monitor and printed out on a color printer. A gold micro-structure was fabricated and used to control the optical retardation. Polarizing micrographs were collected and compared with the calculated colors. Second, the influence of a bias voltage on the surface-driven orientational transition of liquid crystals resulted from the weakening anchoring and anchoring transition is analyzed theoretically and experimentally. The same interdigitated Au micro-structure was used in the nematic LC based chemical and biological sensors. With a suitable bias electric field, the process of the weakening anchoring energy and the uniform surface-driven orientational transition due to targeted molecules binding to a functionalized surface were observed optically. Finally, measurement of optical transmission was used to monitor the anchoring change. Polarizing micrographs were collected and compared with simulated textures. Experimental and simulation results both demonstrate the optical method can effectively monitor the surface anchoring change due to the presence of targeted analytes. These results show that these optical techniques are suitable for LC based sensing

  2. Murasaki: a fast, parallelizable algorithm to find anchors from multiple genomes.

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    Kris Popendorf

    Full Text Available BACKGROUND: With the number of available genome sequences increasing rapidly, the magnitude of sequence data required for multiple-genome analyses is a challenging problem. When large-scale rearrangements break the collinearity of gene orders among genomes, genome comparison algorithms must first identify sets of short well-conserved sequences present in each genome, termed anchors. Previously, anchor identification among multiple genomes has been achieved using pairwise alignment tools like BLASTZ through progressive alignment tools like TBA, but the computational requirements for sequence comparisons of multiple genomes quickly becomes a limiting factor as the number and scale of genomes grows. METHODOLOGY/PRINCIPAL FINDINGS: Our algorithm, named Murasaki, makes it possible to identify anchors within multiple large sequences on the scale of several hundred megabases in few minutes using a single CPU. Two advanced features of Murasaki are (1 adaptive hash function generation, which enables efficient use of arbitrary mismatch patterns (spaced seeds and therefore the comparison of multiple mammalian genomes in a practical amount of computation time, and (2 parallelizable execution that decreases the required wall-clock and CPU times. Murasaki can perform a sensitive anchoring of eight mammalian genomes (human, chimp, rhesus, orangutan, mouse, rat, dog, and cow in 21 hours CPU time (42 minutes wall time. This is the first single-pass in-core anchoring of multiple mammalian genomes. We evaluated Murasaki by comparing it with the genome alignment programs BLASTZ and TBA. We show that Murasaki can anchor multiple genomes in near linear time, compared to the quadratic time requirements of BLASTZ and TBA, while improving overall accuracy. CONCLUSIONS/SIGNIFICANCE: Murasaki provides an open source platform to take advantage of long patterns, cluster computing, and novel hash algorithms to produce accurate anchors across multiple genomes with

  3. Safety, stability and lifestyle: dominant career anchors among the heads of Slovenia’s market orientated agricultural holdings

    Directory of Open Access Journals (Sweden)

    Eva Boštjančič

    2015-12-01

    Full Text Available The paper is identifying the dominant career anchors among the heads of Slovenia’s market orientated agricultural holdings. The dominant anchors are the safety and stability anchors, followed by the lifestyle anchor. This suggests that the heads of Slovenian agricultural holdings want not only a stable, safe and predictable working environment, but also autonomy and a certain degree of flexibility in organising their work. The career anchors referred to in the agricultural holdings surveyed also indicate a lack of managerial skills among farmers, and there are only few references made to the challenge anchor. The development of agriculture and strong competition are now forcing Slovenian farmers to deal with several challenges, seek new opportunities and manage agricultural holdings in a responsible manner.

  4. DEVELOPMENT OF DUAL ANCHORED SHEET PILE WALL METHOD TO INCREASE FRONT WATER DEPTH AND SEISMIC RESISTANCE OF EXISTING QUAY

    Science.gov (United States)

    Nakamura, Yasushi; Sato, Masakatsu; Kikuchi, Yoshiaki; Sugano, Takahiro; Morikawa, Yoshiyuki; Hoshino, Masami; Miki, Kenichi

    Recently the dual anchored sheet pile wall method has been developed to increase a front water depth and seismic resistance of existing quay walls by providing an additional anchor in the lower level of them to reduce a flexural moment of the sheet piles and a tension of the anchors. The existing technical information is not enough to evaluate the seismic behavior and the retrofit of the quay walls with anchors at two different levels. Therefore the experiments with a scale model set on the vibration table of the centrifugal apparatus as well as two dimensional effective stress analyses have been mobilized to investigate the seismic retrofit of the dual anchored sheet pile wall. The experiments and analyses demonstrate the increase the earthquake resistance of quay walls, because they showed the additional anchor can reduce the stress of the sheet walls to one half.

  5. Results of the ANCHOR prospective, multicenter registry of EndoAnchors for type Ia endoleaks and endograft migration in patients with challenging anatomy.

    Science.gov (United States)

    Jordan, William D; Mehta, Manish; Varnagy, David; Moore, William M; Arko, Frank R; Joye, James; Ouriel, Kenneth; de Vries, Jean-Paul

    2014-10-01

    Proximal attachment site complications continue to occur after endovascular repair of abdominal aortic aneurysms (EVAR), specifically type Ia endoleak and endograft migration. EndoAnchors (Aptus Endosystems, Sunnyvale, Calif) were designed to enhance endograft proximal fixation and sealing, and the current study was undertaken to evaluate the potential benefit of this treatment. During the 23-month period ending in December 2013, 319 subjects were enrolled at 43 sites in the United States and Europe. EndoAnchors were implanted in 242 patients (75.9%) at the time of an initial EVAR procedure (primary arm) and in 77 patients with an existing endograft and proximal aortic neck complications (revision arm). Technical success was defined as deployment of the desired number of EndoAnchors, adequate penetration of the vessel wall, and absence of EndoAnchor fracture. Procedural success was defined as technical success without a type Ia endoleak at completion angiography. Values are expressed as mean ± standard deviation and interquartile range. The 238 male (74.6%) and 81 female (25.4%) subjects had a mean age of 74.1 ± 8.2 years. Aneurysms averaged 58 ± 13 (51-63) mm in diameter at the time of EndoAnchor implantation (core laboratory measurements). The proximal aortic neck averaged 16 ± 13 (7-23) mm in length (42.7% <10 mm and 42.7% conical) and 27 ± 4 mm (25-30 mm) in diameter; infrarenal neck angulation was 24 ± 15 (13-34) degrees. The number of EndoAnchors deployed was 5.8 ± 2.1 (4-7). Technical success was achieved in 303 patients (95.0%) and procedural success in 279 patients (87.5%), 217 of 240 (89.7%) and 62 of 77 (80.5%) in the primary and revision arms, respectively. There were 29 residual type Ia endoleaks (9.1%) at the end of the procedure. During mean follow-up of 9.3 ± 4.7 months, 301 patients (94.4%) were free from secondary procedures. Among the 18 secondary procedures, eight were performed for residual type Ia endoleaks and the others

  6. Differences regarding job satisfaction and job involvement of psychologists with different dominant career anchors

    Directory of Open Access Journals (Sweden)

    CL Bester

    2006-09-01

    Full Text Available In order to contribute to higher levels of job satisfaction, job involvement , and productivity, a match or fit should be established between the dominant career anchor associated with a specific occupation and that of the employee. A career anchor is an individual’s set of self-perceived talents, abilities, motives, needs and values that form the nucleus of one’s occupational self-concept. Psychologists have always been part of the service orientated careers and therefore one would expect that it is likely that their dominant career anchor would be service orientation. If this is the case, psychologists with service as their dominant career anchor are supposed to have greater job satisfaction and job involvement compared to those with different career anchors. However, according to literature, this assumption is not necessarily correct. The primary goals of the current study were to determine whether in fact service is the dominant career anchor of psychologists in the Free State and whether there are significant differences regarding job satisfaction and job involvement between psychologists with and without service as their dominant career anchor. A third goal was to determine whether psychologists with different dominant career anchors differ significantly from one another regarding job satisfaction and job involvement. Questionnaires measuring career orientations, job satisfaction and job involvement were sent to 165 of the 171 registered psychologists in the Free State region. Only 75 psychologists (45,5% responded which exceeded the traditional return rate of 20 to 30%. Due to the small sample of respondents, a nonparametric statistical test, namely the Mann Whitney U test was conducted to determine possible differences. An analysis of the data showed that 21 respondents had entrepreneurship as their dominant career orientation while 12 fell in the technical/functional, 12 in the challenging, 9 in the service and 8 in the autonomy

  7. Differences regarding job satisfaction and job involvement of psychologists with different dominant career anchors.

    Science.gov (United States)

    Bester, C L; Mouton, T

    2006-08-01

    In order to contribute to higher levels of job satisfaction, job involvement and productivity, a match or fit should be established between the dominant career anchor associated with a specific occupation and that of the employee. A career anchor is an individual's set of self-perceived talents, abilities, motives, needs and values that form the nucleus of one's occupational self-concept. Psychologists have always been part of the service orientated careers and therefore one would expect that it is likely that their dominant career anchor would be service orientation. If this is the case, psychologists with service as their dominant career anchor are supposed to have greater job satisfaction and job involvement compared to those with different career anchors. However, according to literature, this assumption is not necessarily correct. The primary goals of the current study were to determine whether in fact service is the dominant career anchor of psychologists in the Free State and whether there are significant differences regarding job satisfaction and job involvement between psychologists with and without service as their dominant career anchor. A third goal was to determine whether psychologists with different dominant career anchors differ significantly from one another regarding job satisfaction and job involvement. Questionnaires measuring career orientations, job satisfaction and job involvement were sent to 165 of the 171 registered psychologists in the Free State region. Only 75 psychologists (45,5%) responded which exceeded the traditional return rate of 20 to 30%. Due to the small sample of respondents, a nonparametric statistical test, namely the Mann Whitney U test was conducted to determine possible differences. An analysis of the data showed that 21 respondents had entrepreneurship as their dominant career orientation while 12 fell in the technical/functional, 12 in the challenging, 9 in the service and 8 in the autonomy categories of dominant

  8. Mechanical performance of a screw-type veterinary suture anchor subjected to single load to failure and cyclic loads.

    Science.gov (United States)

    Balara, Jason M; McCarthy, Robert J; Boudrieau, Randy J; Kraus, Karl H

    2004-01-01

    To characterize the mechanical performance of a veterinary bone anchor under static and cyclic loads. Mechanical testing study. Cadaveric canine humeri. Humeri (6 pairs) were collected from skeletally mature dogs (mean [+/-SD] age, 17.2+/-2.1 months; weight, 20.8+/-1.5 kg). Bone anchors were inserted in the proximal metaphysis using nylon, and were longitudinally extracted. For the opposite humerus, anchors were subjected to longitudinal cyclic load (50% of the load at failure of their pair) for 1200 cycles then longitudinally loaded to failure. Anchors were then installed in a similar and adjacent area of these 2(nd) humeri with nylon and cyclically tested perpendicular to the axis of anchor insertion (100% of the longitudinal holding power of their pair) for 1200 cycles, then perpendicularly loaded to failure. Paired t-tests were used to compare holding power before and after longitudinal cyclic testing. Longitudinal holding power of the screw-type anchor in the proximal humerus was 385+/-30 N. Anchor pullout was the only mode of failure. Anchors in the paired humeri did not fail after 1200 cycles of 50% longitudinal loading, and post-cycle holding strength was not different (335+/-87 N; P=.32). Perpendicularly loaded anchors did not fail after 1200 cycles of 100% of opposite longitudinal holding strength, and had post-cycle perpendicular holding strengths of 514+/-72 N. Suture breakage was the mode of failure. Bone anchor holding strength is dependent on orientation of suture load. Screw-type bone anchor holding strength was not affected by longitudinal cyclic loading, and holding strengths of approximately 385 N can be expected in metaphyseal bone of large-breed mature dogs. Perpendicularly loaded anchors have higher failure loads, and holding strength of approximately 514 N can be expected in metaphyseal bone of the proximal humerus.

  9. Mitochondria-driven assembly of a cortical anchor for mitochondria and dynein.

    Science.gov (United States)

    Kraft, Lauren M; Lackner, Laura L

    2017-10-02

    Interorganelle contacts facilitate communication between organelles and impact fundamental cellular functions. In this study, we examine the assembly of the MECA (mitochondria-endoplasmic reticulum [ER]-cortex anchor), which tethers mitochondria to the ER and plasma membrane. We find that the assembly of Num1, the core component of MECA, requires mitochondria. Once assembled, Num1 clusters persistently anchor mitochondria to the cell cortex. Num1 clusters also function to anchor dynein to the plasma membrane, where dynein captures and walks along astral microtubules to help orient the mitotic spindle. We find that dynein is anchored by Num1 clusters that have been assembled by mitochondria. When mitochondrial inheritance is inhibited, Num1 clusters are not assembled in the bud, and defects in dynein-mediated spindle positioning are observed. The mitochondria-dependent assembly of a dual-function cortical anchor provides a mechanism to integrate the positioning and inheritance of the two essential organelles and expands the function of organelle contact sites. © 2017 Kraft and Lackner.

  10. Study on monitoring of deep foundation pit with SMW engineering method plus anchor cable retaining structure

    Science.gov (United States)

    Chen, Wenzhao; Cui, Wenping

    2018-03-01

    The SMW method has many advantages, such as little influence on the surrounding environment, good watertight performance, wide range of application, short construction period, low cost and so on. In this paper, we chose the SMW engineering method combined with anchor cable to support structure in the second phase deep foundation pit of Jinan LuJinDongCheng as the research object, monitored and analysed the horizontal displacement of the pile top, Peripheral surface subsidence and internal force of the anchor cable in the foundation pit. We also discussed the displacement, internal force of anchor cable and the settlement of surrounding environment in the excavation of foundation pit and in different stages of construction. Conclusion:(1)The maximum horizontal displacement of the retaining structure is closely related to the depth and time of excavation, the construction of anchor cable can well limit the deformation of pile body; (2)Groundwater seepage caused by foundation pit dewatering will change the effective stress of soil. The change of groundwater level has an important influence on the working behavior of smw anchor cable supporting structure.

  11. A Study on the Holding Capacity Safety Factors for Torpedo Anchors

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    Luís V. S. Sagrilo

    2012-01-01

    Full Text Available The use of powerful numerical tools based on the finite-element method has been improving the prediction of the holding capacity of fixed anchors employed by the offshore oil industry. One of the main achievements of these tools is the reduction of the uncertainty related to the holding capacity calculation of these anchors. Therefore, it is also possible to reduce the values of the associated design safety factors, which have been calibrated relying on models with higher uncertainty, without impairing the original level of structural safety. This paper presents a study on the calibration of reliability-based safety factors for the design of torpedo anchors considering the statistical model uncertainty evaluated using results from experimental tests and their correspondent finite-element-based numerical predictions. Both working stress design (WSD and load and resistance factors design (LRFD design methodologies are investigated. Considering the WSD design methodology, the single safety is considerably lower than the value typically employed in the design of torpedo anchors. Moreover, a LRFD design code format for torpedo anchors is more appropriate since it leads to designs having less-scattered safety levels around the target value.

  12. Synergism Analysis of Bedding Slope with Piles and Anchor Cable Support under Sine Wave Vehicle Load

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    Li Dan-Feng

    2016-01-01

    Full Text Available Slope instability under dynamic load is the technical difficulty in the engineering; the evaluation of slope stability under dynamic load and the control of dynamic load is particularly important. In this paper, taking the right side slope of K27+140 m~380 m typical section (K27 slope for short in Chongqing Fuling-Fengdu-Shizhu expresses highway as an example to calculate and analyze. The K27 slope is under sinusoidal vehicle load and supported by anchor cable and antislide pile to resist downslide strength; at the same time, the combined effect of them is studied. Three-dimensional finite element methodology (FEM is used to simulate the bedding slope with piles and anchor cable support; furthermore, the eigenvalue can be obtained. In order to reduce error of the elastic boundary conditions caused by the reflection effect of wavelengths, the combination of Lysmer surface viscous boundary and traditional ground support boundaries is utilized to analyze and calculate the time-histories during bedding slope under dynamic load. The dynamic response of pile anchor support to resist sliding force is obtained. The concept of the pile anchor supporting coordinate interval is put forward. Furthermore, it is verified that the pile anchor supporting coordinate interval can be used to evaluate the stability of the slope under dynamic load and provide a new method for the control of the dynamic load.

  13. Interference Screw vs. Suture Anchor Fixation for Open Subpectoral Biceps Tenodesis: Does it Matter?

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    Gobezie Reuben

    2008-09-01

    Full Text Available Abstract Background Bioabsorbable interference screw fixation has superior biomechanical properties compared to suture anchor fixation for biceps tenodesis. However, it is unknown whether fixation technique influences clinical results. Hypothesis We hypothesize that subpectoral interference screw fixation offers relevant clinical advantages over suture anchor fixation for biceps tenodesis. Study Design Case Series. Methods We performed a retrospective review of a consecutive series of 88 patients receiving open subpectoral biceps tenodesis with either interference screw fixation (34 patients or suture anchor fixation (54 patients. Average follow up was 13 months. Outcomes included Visual Analogue Pain Scale (0–10, ASES score, modified Constant score, pain at the tenodesis site, failure of fixation, cosmesis, deformity (popeye and complications. Results There were no failures of fixation in this study. All patients showed significant improvement between their preoperative and postoperative status with regard to pain, ASES score, and abbreviated modified Constant scores. When comparing IF screw versus anchor outcomes, there was no statistical significance difference for VAS (p = 0.4, ASES score (p = 0.2, and modified Constant score (P = 0.09. One patient (3% treated with IF screw complained of persistent bicipital groove tenderness, versus four patients (7% in the SA group (nonsignificant. Conclusion Subpectoral biceps tenodesis reliably relieves pain and improves function. There was no statistically significant difference in the outcomes studied between the two fixation techniques. Residual pain at the site of tenodesis may be an issue when suture anchors are used in the subpectoral location.

  14. Ultraweak azimuthal anchoring of a nematic liquid crystal on a planar orienting photopolymer

    International Nuclear Information System (INIS)

    Nespoulous, Mathieu; Blanc, Christophe; Nobili, Maurizio

    2007-01-01

    The search of weak anchoring is an important issue for a whole class of liquid crystal displays. In this paper we present an orienting layer showing unreached weak planar azimuthal anchoring for 4-n-pentyl-4 ' -cyanobiphenyl nematic liquid crystal (5CB). Azimuthal extrapolation lengths as large as 80 μm are easily obtained. Our layers are made with the commercial photocurable polymer Norland optical adhesive 60. The anisotropy of the film is induced by the adsorption of oriented liquid crystal molecules under a 2 T magnetic field applied parallel to the surfaces. We use the width of surface π-walls and a high-field electro-optical method to measure, respectively, the azimuthal and the zenithal anchorings. The azimuthal anchoring is extremely sensitive to the ultraviolet (UV) dose and it also depends on the magnetic field application duration. On the opposite, the zenithal anchoring is only slightly sensitive to the preparation parameters. All these results are discussed in terms of the adsorption/desorption mechanisms of the liquid crystal molecules on the polymer layer and of the flexibility of the polymer network

  15. Septal anchoring suture: a key suture to improve the nasolabial symmetry in unilateral cheiloplasty.

    Science.gov (United States)

    Lu, T-C; Filson, S; Yao, C-F; Chen, P K-T

    2018-04-03

    Since 2008, a septal anchoring suture has been used in unilateral cleft lip repair at Chang Gung Memorial Hospital in order to stabilize the lateral lip centrally. This study compared the symmetry of two groups of patients: those treated with and without an anchoring suture. Multiple standardized direct and photographic facial measurements were performed on the faces of all patients pre-cheiloplasty and at 5 years post-cheiloplasty. The degree of nasolabial symmetry was evaluated by comparing the ratios of measurements of the cleft vs. non-cleft sides. The ratio of change in these measurements was also compared postoperatively. The vertical lip length ratio approached 1 in the septal anchoring suture group, which differed significantly from the group without the suture (0.968 vs. 0.873, P<0.001). As expected, the horizontal lip length and central lip height ratios showed no statistically significant change. The ratio of change from pre- to postoperative also showed a significant improvement (P=0.028) in the vertical lip length of the group with the septal anchoring suture compared to the one without. The septal anchoring suture is a useful method to correct the tendency of the lip to shift to the cleft side. Copyright © 2018 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

  16. Intramodal and crossmodal pairing and anchoring in comparisons of successive stimuli.

    Science.gov (United States)

    Hellström, Åke; Cederström, Caroline

    2014-05-01

    Two experiments were conducted to study effects of modality, temporal position, and their interaction on comparisons of successive stimuli. In Experiment 1, intramodal (tone-tone and line-line) and crossmodal (tone-line and line-tone) stimulus pairs, with two interstimulus intervals (ISIs), 400 and 2,000 ms, were presented. Participants indicated which stimulus was the "stronger." Time-order errors (TOEs) were assessed using the D% measure and were found in all types of pairs. Variation in TOEs across conditions was well accounted for by changes in parameters (stimulus weights, reference levels) in an extended version of Hellström's sensation weighting (SW) model. With an ISI of 2,000 ms, the first stimulus had a lower weight (less impact on the response) than did the second stimulus. More negative TOEs were found with the longer ISI in all pair types except tone-line. In Experiment 2, participants indicated which of two lines was the longer or which of two tones was the louder. An intra- or crossmodal anchor, or no anchor, was interpolated between the stimuli. Anchoring tended to reduce the weight of the first stimulus, suggesting interference with memory, and to yield negative TOEs. Intramodal anchors yielded reduced weights of both stimuli, most dramatically for tones, suggesting an additional effect of stimulus interference. Response times decreased with crossmodal anchors. For line-line pairs, strong negative TOEs were found. In both experiments, the variation in TOE across conditions was well accounted for by the SW model.

  17. Structural models of the membrane anchors of envelope glycoproteins E1 and E2 from pestiviruses

    Science.gov (United States)

    Wang, Jimin; Li, Yue; Modis, Yorgo

    2014-01-01

    The membrane anchors of viral envelope proteins play essential roles in cell entry. Recent crystal structures of the ectodomain of envelope protein E2 from a pestivirus suggest that E2 belongs to a novel structural class of membrane fusion machinery. Based on geometric constraints from the E2 structures, we generated atomic models of the E1 and E2 membrane anchors using computational approaches. The E1 anchor contains two amphipathic perimembrane helices and one transmembrane helix; the E2 anchor contains a short helical hairpin stabilized in the membrane by an arginine residue, similar to flaviviruses. A pair of histidine residues in the E2 ectodomain may participate in pH sensing. The proposed atomic models point to Cys987 in E2 as the site of disulfide bond linkage with E1 to form E1–E2 heterodimers. The membrane anchor models provide structural constraints for the disulfide bonding pattern and overall backbone conformation of the E1 ectodomain. PMID:24725935

  18. Towards robot-assisted anchor deployment in beating-heart mitral valve surgery.

    Science.gov (United States)

    Cheng, Lingbo; Sharifi, Mojtaba; Tavakoli, Mahdi

    2018-03-24

    Beating-heart intracardiac surgery promises significant benefits for patients compared with cardiopulmonary bypass based procedures. However, the fast motions of the heart introduce serious challenges for surgeons. In this work, a new impedance-controlled master-slave telerobotic system is developed to help perform anchor deployment for mitral valve annuloplasty under the guidance of live ultrasound images of the heart. The proposed bilateral teleoperation system can both reflect the non-oscillatory portion of slave-heart tissue interaction force on the surgeon's hand as haptic feedback and implement rapid compensation for the beating heart's motion. The surgical task involves performing anchor deployment on a simulated moving heart tissue to evaluate the effectiveness of the proposed strategy for safely interacting with a moving organ. The results obtained show that the telerobotic system increases the success rate of anchor deployment by 100% and reduces the excess force application rate by 70% compared with manual attempts. Copyright © 2018 John Wiley & Sons, Ltd.

  19. Discriminative ability of two different external anchors: improvement appears better than importance

    DEFF Research Database (Denmark)

    Lauridsen, Henrik Hein

    2009-01-01

    Title:    Discriminative ability of two different external anchors: improvement appears better than importance. Authors and affiliation: Henrik H. Lauridsen, DC, MSc, PhD*, Claus Manniche, MD, DMSc‡, Werner Vach, PhD §, Niels Grunnet-Nilsson DC, MD, PhD*, Jan Hartvigsen, DC, PhD*† * Clinical...... and baseline dependence have been raised, and little attention has been paid to how improvement and importance of a treatment outcome should be interpreted. The purpose of this study is to explore the adequateness of two different external anchors using the anchor-based MIC distribution method and probability...... of improvement/importance curves. Methods Two hundred and twenty-four patients with chronic low back pain and/or leg pain were recruited from an out-patient hospital back pain clinic and followed over an 8-week period. Participants received the Danish Oswestry Disability Index (ODI), the numeric rating scale...

  20. Successful bone-anchored hearing aid implantation in a patient with osteogenesis imperfecta.

    Science.gov (United States)

    Coutinho, M B; Marques, C; Mendes, G J; Gonçalves, C

    2015-11-01

    To report a case of successful bone-anchored hearing aid implantation in an adult patient with type III osteogenesis imperfecta, which is commonly regarded as a contraindication to this procedure. A 45-year-old man with type III osteogenesis imperfecta presented with mixed hearing loss. There was a mild sensorineural component in both ears, with an air-bone gap between 45 and 50 dB HL. He was implanted with a bone-anchored hearing aid. The audiological outcome was good, with no complications and good implant stability (as measured by resonance frequency analysis). To our knowledge, this is the first recorded case of bone-anchored hearing aid implantation in a patient with osteogenesis imperfecta.

  1. Anchor-free NEMS non-volatile memory cell for harsh environment data storage

    International Nuclear Information System (INIS)

    Singh, Pushpapraj; Chua, Geng Li; Liang, Ying Shun; Jayaraman, Karthik Gopal; Do, Anh Tuan; Kim, Tony Tae-Hyoung

    2014-01-01

    This work demonstrates a novel anchor-free nano-electromechanical (NEMS) based non-volatile memory cell, suitable for high temperature (T ≤ 300 °C) and radiation prone harsh environment applications. The anchor-free circular metal beam is actuated by electrostatic force and is held in one of the bi-stable memory states by adhesion force between two smooth metal surfaces in contact. Smooth metal layers form strong van der Waals stiction between two surfaces in contact and memory detection (Logic-‘1’ / Logic-‘0’) is obtained by detecting the conductance between two fixed contacts. This anchor-free design offers highest density (9F 2 footprint) compared to other mechanical memory devices reported to date. (paper)

  2. Class I major histocompatibility complex anchor substitutions alter the conformation of T cell receptor contacts.

    Science.gov (United States)

    Sharma, A K; Kuhns, J J; Yan, S; Friedline, R H; Long, B; Tisch, R; Collins, E J

    2001-06-15

    An immunogenic peptide (GP2) derived from HER-2/neu binds to HLA-A2.1 very poorly. Some altered-peptide ligands (APL) of GP2 have increased binding affinity and generate improved cytotoxic T lymphocyte recognition of GP2-presenting tumor cells, but most do not. Increases in binding affinity of single-substitution APL are not additive in double-substitution APL. A common first assumption about peptide binding to class I major histocompatibility complex is that each residue binds independently. In addition, immunologists interested in immunotherapy frequently assume that anchor substitutions do not affect T cell receptor contact residues. However, the crystal structures of two GP2 APL show that the central residues change position depending on the identity of the anchor residue(s). Thus, it is clear that subtle changes in the identity of anchor residues may have significant effects on the positions of the T cell receptor contact residues.

  3. Traction endurance biomechanical study of metallic suture anchors at different insertion angles

    Directory of Open Access Journals (Sweden)

    Azato Flávia Namie

    2003-01-01

    Full Text Available The suture anchors' insertion angle and its traction resistance are the main subjects of this study. Twenty trials were realized using threaded suture anchors in four diferents angulations (30º /45º /60º /90º in human bone (distal femur and another twenty trials in artificial bone (SawboneTM. The anchors were pulled out being tractioned uprightly from its bone surface by a Kratos Universal test machine. The human bone results found no relation between the main subjects of this study, so whithout statistical value. On the other hand at the artificial bone the insertion angle of 90º beared more traction, being statistically significant compared to the other angles.

  4. Career anchor profiles of a sample of business and professional women

    Directory of Open Access Journals (Sweden)

    Ronel Erwee

    1990-06-01

    Full Text Available The career anchors of a sample of 95 business and professional woman were studied by means of the Career Orientations Inventory (DeLong, 1982. The hierarchy of career anchors of the sample was as follows: Service, Variety, Security (job tenure, Managerial competence. Autonomy, Identity, Technical/functional competence, Entrepreneurship and Security (geographical location. A few significant differences in career anchors did occur between various occupational groups. The implicatons of these findings in terms of career management in organisations are discussed. Opsomming Die loopbaanankers van 'n steekproef van 95 sake- en beroepsvroue is bestudeer deur middel van die "Career Orientations Inventory" (DeLong, 1982. Die steekproef het die volgende hierargie van loopbaanankers getoon: Diens, Verskeidenheid, Sekuriteit (organisatories, Bestuursbevoegdheid, Outonomie, Identiteit, Tegnies/funksionele bevoegdheid, Entrepreneurskap en Sekuriteit (geografies. 'n Paar beduidende verskille in loopbaanankerprofiele het tussen die onderskeie beroepsgroepe voorgekom. Die implikasies van die bevindings ten opsigte van loopbaanbeplanning in ondernemings word bespreek.

  5. Z-plasty for skin complications of bone-anchored hearing aid implantation.

    Science.gov (United States)

    Miura, M S; Rios, M N

    2015-06-01

    The bone-anchored hearing aid implantation technique is associated with post-operative skin reactions, which require conservative therapy and, in some cases, replacement of the abutment. Z-plasty is a technique that allows resection of the granulation tissue, thus ensuring that disease-free skin will be in contact with the abutment. Use of the Z-plasty technique for resection of the peri-abutment granulation tissue is described. In the case presented herein, the episodes of skin reaction became very frequent and the patient was unable to use his bone-anchored hearing aid for 2 to 3 days a week. We opted for surgical treatment with Z-plasty for management of the skin complications. Use of the Z-plasty technique is recommended for the management of skin reactions associated with bone-anchored hearing aid implantation.

  6. Study of lateral mode SOI-MEMS resonators for reduced anchor loss

    International Nuclear Information System (INIS)

    Lee, Joshua E-Y; Yan, Jize; Seshia, Ashwin A

    2011-01-01

    MEMS resonators fabricated in silicon-on-insulator (SOI) technology must be clamped to the substrate via anchoring stems connected either from within the resonator or through the sides, with the side-clamped solution often employed due to manufacturing constraints. This paper examines the effect of two types of commonly used side-clamped, anchoring-stem geometries on the quality factor of three different laterally-driven resonator topologies. This study employs an analytical framework which considers the relative distribution of strain energies between the resonating body and clamping stems. The ratios of the strain energies are computed using ANSYS FEA and used to provide an indicator of the expected anchor-limited quality factors. Three MEMS resonator topologies have been fabricated and characterized in moderate vacuum. The associated measured quality factors are compared against the computed strain energy ratios, and the trends are shown to agree well with the experimental data.

  7. Factors related to furniture anchoring: a method for reducing harm during earthquakes.

    Science.gov (United States)

    Haraoka, Tomoko; Hayasaka, Shinya; Murata, Chiyoe; Yamaoka, Taiji; Ojima, Toshiyuki

    2013-02-01

    Fatalities and injuries during an earthquake can be reduced by taking preemptive measures before-hand, and furniture anchoring is an important safety measure for all residents. This study sought to clarify the factors associated with furniture anchoring within the home. A self-administered mail survey was completed from July to August 2010 by 3500 men and women between the ages of 20 and 69 years who were chosen at random from an official government resident registry of 2 cities in Japan. Of the 1729 valid responses, 37.1% reported furniture anchoring. An association with furniture anchoring was observed for having viewed earthquake intensity maps or damage predictions (odds ratio [OR] 1.92, 95% C1 1.54-2.39), expressing concern about a future earthquake (OR 2.07, 95% C1 1.36-3.15), feelings of urgency (OR 1.90, 95% CI 1.47-2.45), accuracy of the government disaster preparedness information (OR 1.68, 95% CI 1.17-2.42), knowledge of the meaning of emergency earthquake warnings (OR 1.67, 95% CI 1.12-2.48), and participation in voluntary disaster preparedness activities (OR 1.40, 95% C1 1.12-1.75). Furniture anchoring was found to be associated with risk awareness, risk perception, disaster preparedness information provided by government to residents, knowledge of earthquakes, participation in voluntary disaster preparedness activities, nonwooden structures, and marital status. An increase in furniture anchoring is important and can be achieved through education and training in daily life.

  8. Interactions of frazil and anchor ice with sedimentary particles in a flume

    Science.gov (United States)

    Kempema, E.W.; Reimnitz, E.; Clayton, J.R.; Payne, J.R.

    1993-01-01

    Frazil and anchor ice forming in turbulent, supercooled water have been studied extensively because of problems posed to man-made hydraulic structures. In spite of many incidental observations of interactions of these ice forms with sediment, their geologic effects remain unknown. The present flume study was designed to learn about the effects of salinity, current speed, and sediment type on sediment dynamics in supercooled water. In fresh-water, frazil ice formed flocs as large as 8 cm in diameter that tended to roll along a sandy bottom and collect material from the bed. The heavy flocs often came to rest in the shelter of ripples, forming anchor ice that subsequently was buried by migrating ripples. Burial compressed porous anchor ice into ice-bonded, sediment-rich masses. This process disrupts normal ripple cross-bedding and may produce unique sedimentary structures. Salt-water flocs were smaller, incorporated less bed load, and formed less anchor ice than their fresh-water counterparts. In four experiments, frazil carried a high sediment load only for a short period in supercooled salt water, but released it with slight warming. This suggests that salt-water frazil is either sticky or traps particles only while surrounded by supercooled water (0.05 to 0.1 ??C supercooling), a short-lived phase in simple, small tanks. Salt water anchor ice formed readily on blocks of ice-bonded sediment, which may be common in nature. The theoretical maximum sediment load in neutrally-buoyant ice/sediment mixture is 122 g/l, never reported in nature so far. The maximum sediment load measured in this laboratory study was 88 g/l. Such high theoretical and measured sediment concentrations suggest that frazil and anchor ice are important sediment transport agents in rivers and oceans. ?? 1993.

  9. Proposed Methodology for Design of Carbon Fiber Reinforced Polymer Spike Anchors into Reinforced Concrete

    Energy Technology Data Exchange (ETDEWEB)

    MacFarlane, Eric Robert [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-05-26

    The included methodology, calculations, and drawings support design of Carbon Fiber Reinforced Polymer (CFRP) spike anchors for securing U-wrap CFRP onto reinforced concrete Tbeams. This content pertains to an installation in one of Los Alamos National Laboratory’s facilities. The anchors are part of a seismic rehabilitation to the subject facility. The information contained here is for information purposes only. The reader is encouraged to verify all equations, details, and methodology prior to usage in future projects. However, development of the content contained here complied with Los Alamos National Laboratory’s NQA-1 quality assurance program for nuclear structures. Furthermore, the formulations and details came from the referenced published literature. This literature represents the current state of the art for FRP anchor design. Construction personnel tested the subject anchor design to the required demand level demonstrated in the calculation. The testing demonstrated the ability of the anchors noted to carry loads in excess of 15 kips in direct tension. The anchors were not tested to failure in part because of the hazards associated with testing large-capacity tensile systems to failure. The calculation, methodology, and drawing originator was Eric MacFarlane of Los Alamos National Laboratory’s (LANL) Office of Seismic Hazards and Risk Mitigation (OSHRM). The checker for all components was Mike Salmon of the LANL OSHRM. The independent reviewers of all components were Insung Kim and Loring Wyllie of Degenkolb Engineers. Note that Insung Kim contributed to the initial formulations in the calculations that pertained directly to his Doctoral research.

  10. A general pipeline for the development of anchor markers for comparative genomics in plants

    Directory of Open Access Journals (Sweden)

    Stougaard Jens

    2006-08-01

    Full Text Available Abstract Background Complete or near-complete genomic sequence information is presently only available for a few plant species representing a large phylogenetic diversity among plants. In order to effectively transfer this information to species lacking sequence information, comparative genomic tools need to be developed. Molecular markers permitting cross-species mapping along co-linear genomic regions are central to comparative genomics. These "anchor" markers, defining unique loci in genetic linkage maps of multiple species, are gene-based and possess a number of features that make them relatively sparse. To identify potential anchor marker sequences more efficiently, we have established an automated bioinformatic pipeline that combines multi-species Expressed Sequence Tags (EST and genome sequence data. Results Taking advantage of sequence data from related species, the pipeline identifies evolutionarily conserved sequences that are likely to define unique orthologous loci in most species of the same phylogenetic clade. The key features are the identification of evolutionarily conserved sequences followed by automated design of intron-flanking Polymerase Chain Reaction (PCR primer pairs. Polymorphisms can subsequently be identified by size- or sequence variation of PCR products, amplified from mapping parents or populations. We illustrate our procedure in legumes and grasses and exemplify its application in legumes, where model plant studies and the genome- and EST-sequence data available have a potential impact on the breeding of crop species and on our understanding of the evolution of this large and diverse family. Conclusion We provide a database of 459 candidate anchor loci which have the potential to serve as map anchors in more than 18,000 legume species, a number of which are of agricultural importance. For grasses, the database contains 1335 candidate anchor loci. Based on this database, we have evaluated 76 candidate anchor loci

  11. The utilisation of a career conversation framework based on Schein’s career anchors model

    Directory of Open Access Journals (Sweden)

    Magda Bezuidenhout

    2013-07-01

    Full Text Available Orientation: This  study  constituted  and  reported  on  the  outcomes  of  a  structured  career conversation  framework  based  on  Schein’s  eight  career  anchors  in  an  open  distance  and e-learning (ODeL university in South Africa. Research purpose: The purpose of the research was to report on the utilisation of a structured career conversation framework based on Schein’s career anchors model. Motivation for the study: The rationale for the study was the paucity of studies investigating career anchors in South Africa’s multicultural organisational context. Research design, approach and method: A quantitative approach was adopted in the study. The population consisted of 4200 employees at a university in South Africa. Statistical analysis was performed using one-way analysis of variance (ANOVA as well as a Scheffe post hoc test. Main  findings: The  findings  of  this  study  suggest  that  career  conversation  has  a  dynamic nature (i.e. it changes over a period of time. Consequently, career development interventions in the workplace need to approach the workforce holistically. Practical/managerial implications: The findings and results will assist managers, practitioners and  career  development  specialists  in  the  practical  implementation  of  the  career  anchor concept. Contribution/value-add: The career conversation framework based on Schein’s career anchors has expanded the existing theory to find the right balance between career conversations and career anchors to keep people motivated to perform optimally in an organisation.

  12. Biomechanical Analysis of Suture Anchor vs Tenodesis Screw for FHL Transfer.

    Science.gov (United States)

    Drakos, Mark C; Gott, Michael; Karnovsky, Sydney C; Murphy, Conor I; DeSandis, Bridget A; Chinitz, Noah; Grande, Daniel; Chahine, Nadeen

    2017-07-01

    Chronic Achilles injury is often treated with flexor hallucis longus (FHL) tendon transfer to the calcaneus using 1 or 2 incisions. A single incision avoids the risks of extended dissections yet yields smaller grafts, which may limit fixation options. We investigated the required length of FHL autograft and biomechanical profiles for suture anchor and biotenodesis screw fixation. Single-incision FHL transfer with suture anchor or biotenodesis screw fixation to the calcaneus was performed on 20 fresh cadaveric specimens. Specimens were cyclically loaded until maximal load to failure. Length of FHL tendon harvest, ultimate load, stiffness, and mode of failure were recorded. Tendon harvest length needed for suture anchor fixation was 16.8 ± 2.1 mm vs 29.6 ± 2.4 mm for biotenodesis screw ( P = .002). Ultimate load to failure was not significantly different between groups. A significant inverse correlation existed between failure load and donor age when all specimens were pooled (ρ = -0.49, P Screws in younger specimens (fewer than 70) resulted in significantly greater failure loads ( P screw fixation were either tunnel pullout (n = 6) or tendon rupture (n = 4). Anchor failure occurred mostly by suture breakage (n = 8). Adequate FHL tendon length could be harvested through a single posterior incision for fixation to the calcaneus with either fixation option, but suture anchor required significantly less graft length. Stiffness, fixation strength, and load to failure were comparable between groups. An inverse correlation existed between failure load and donor age. Younger specimens with screw fixation demonstrated significantly greater failure loads. Adequate harvest length for FHL transfer could be achieved with a single posterior incision. There was no difference in strength of fixation between suture anchor and biotenodesis screw.

  13. Psychological career resources as predictors of working adults’ career anchors: An exploratory study

    Directory of Open Access Journals (Sweden)

    Melinde Coetzee

    2009-04-01

    Full Text Available This study explored the relationship between the psychological career resources and career anchors of a sample of 2 997 working adults at predominantly managerial and supervisory levels in the service industry. The Psychological Career Resources Inventory and the Career Orientations Inventory were applied. Stepwise regression analyses indicated dimensions of psychological career resources as significant predictors of  participants’ career anchors. The findings add valuable new knowledge that can be used to inform organisational career development support practices as well as career counselling and guidance services concerned with promoting individuals’ employability and experiences of intrinsic career success.

  14. Focused suggestion with somatic anchoring technique: rapid self-hypnosis for pain management.

    Science.gov (United States)

    Donatone, Brooke

    2013-04-01

    This article details a self-hypnosis technique designed to teach patients how to manage acute or chronic pain through directed focus. The focused suggestion with somatic anchoring technique has been used with various types of pain, including somatic pain (arthritis, post-injury pain from bone breaks, or muscle tears), visceral pain (related to irritable bowel disease), and neuropathic pain (related to multiple sclerosis). This technique combines cognitive restructuring and mindfulness meditation with indirect and direct suggestions during hypnosis. The case examples demonstrate how the focused suggestion with somatic anchoring technique is used with both acute and chronic pain conditions when use of long-term medication has been relatively ineffective.

  15. Numerical Study of Mechanical Stirring in Case of Yield Stress Fluid with Circular Anchor Impeller

    Directory of Open Access Journals (Sweden)

    Brahim MEBARKI

    2011-09-01

    Full Text Available In this work the characterization of hydrodynamic fields of incompressible yield stress fluid with regularization model of Bercovier and Engelman in a cylindrical vessel not chicaned equipped with circular anchor stirrer was undertaken by means of numerical simulation using computational fluid dynamics. Simulations flow of a Bingham fluid agitated by straights blades anchor was used to validate the rheological model implemented of the fluid treated. The flow structures, and especially the effect of inertia, the plasticity and the yield stress, are discussed. We have analyzed also the influence of rheological parameters on the hydrodynamic flow behaviours, such as the velocity components and the global characteristic like power consumption.

  16. Approaches to enhance body-anchored and experience-based learning

    DEFF Research Database (Denmark)

    Stelter, Reinhard

    2008-01-01

    Subsequent to the theoretical framework presented in the two earlier contributions to this volume ("Learning Bodies")the aim of this article is to unfold some ideas for the application of body-anchored learning. Some of the basic principles like focusing, perceptual attention training, being...... in the rhythm and intentional orientation can also be applied to different areas, for example, psychotherapy or coaching. But the main focus is on examples from physical education. The final part of the article sees body-anchored learning as integrated in a cultural setting and as part of learning...... in a community of practice....

  17. Silver nanoparticles anchored reduced graphene oxide for enhanced electrocatalytic activity towards methanol oxidation

    Science.gov (United States)

    Kumar, Sanjeev; Mahajan, Mani; Singh, Rajinder; Mahajan, Aman

    2018-02-01

    In this report, silver nanoparticles (Ag NPs) anchored reduced graphene oxide (rGO) sheets (rGO/Ag) nanohybrid has been explored as anode material in direct methanol fuel cells (DMFCs). The synthesized rGO/Ag nanohybrid is characterized by XRD, XPS, FTIR spectroscopy and HRTEM techniques. Cyclic voltammograms demonstrate that the rGO/Ag nanohybrid exhibits higher electrocatalytic activity in comparison to rGO sheets for methanol oxidation reaction (MOR). This enhancement is attributed to the synergetic effect produced by the presence of more active sites provided by Ag NPs anchored on a conducting network of large surface area rGO sheets.

  18. Approaches to enhance body-anchored and experience-based learning

    DEFF Research Database (Denmark)

    Stelter, Reinhard

    2008-01-01

    Subsequent to the theoretical framework presented in the two earlier contributions to this volume ("Learning Bodies")the aim of this article is to unfold some ideas for the application of body-anchored learning. Some of the basic principles like focusing, perceptual attention training, being...... in the rhythm and intentional orientation can also be applied to different areas, for example, psychotherapy or coaching. But the main focus is on examples from physical education. The final part of the article sees body-anchored learning as integrated in a cultural setting and as part of learning...

  19. Technical note: Endoscopic resection of a dermoid cyst anchored to the anterior optic chiasm

    Directory of Open Access Journals (Sweden)

    Yuichiro Yoneoka, MD, PhD

    2014-06-01

    Conclusion: To the best of our knowledge, ours is the only case of a dermoid cyst anchored to the anterior optic chiasma, which was visually confirmed under endoscopic observation. After surgery, the patient presented a transient impairment of the visual field, which was not evident at four month follow-up. It will contribute to a similar case, in which surgeons hesitate to make an incision in the optic chiasm. A subtotal excision should be considered in cases of dermoid cysts anchored to the anterior optic chiasm, because all the previously reported cases of suprasellar dermoid cysts are young people or those who have a relatively long life expectancy.

  20. Functional benefit of the bone-anchored hearing aid with different auditory profiles: objective and subjective measures.

    Science.gov (United States)

    van Wieringen, A; De Voecht, K; Bosman, A J; Wouters, J

    2011-04-01

    To examine sentence recognition and self-report outcomes in hearing-impaired persons with different auditory profiles and who were fitted unilaterally with a bone-anchored hearing aid. Prospective cohort study. Tertiary referral unit. Data were collected of six patients with single-sided deafness (SSD), seven with a mild to severe hearing loss at the bone-anchored hearing aid side and (near-)normal hearing at the other side and six with a severe bilateral hearing loss. Sound field thresholds, and sentence recognition in noise (presented from different angles) with bone-anchored hearing aid, without bone-anchored hearing aid and with bone-anchored hearing aid and other ear occluded. In addition, the Speech, Spatial and Qualities of hearing scale and the Abbreviated Profile of Hearing Aid Benefit questionnaire were administered as self-report measures. Patients with single-sided deafness listened mainly with their non-bone-anchored hearing aid ear, although the bone-anchored hearing aid lifted the head shadow effect. Patients with mild to severe hearing loss at the bone-anchored hearing aid side and (near-)normal hearing at the other side performed significantly differently in aided and unaided conditions and even regained limited binaural sensitivity with the device. The latter was also true for the patients with severe bilateral hearing loss. However, their hearing loss at the non-bone-anchored hearing aid side was too great to contribute to hearing and they listened predominantly with their bone-anchored hearing aid. Self-report outcomes provided useful information on hearing disability, although this information was not significantly differently for the 3 groups of patients. The bone-anchored hearing aid enhanced performance in different hearing configurations, albeit to different extents. © 2011 Blackwell Publishing Ltd.

  1. The effect of a dragging anchor on a horizontal layer of rockfill : A Prototype and a Scale Model Test

    NARCIS (Netherlands)

    Crum, S.; Van der Hoeven, M.L.E.B.; Krouwel, L.P.H.C.; Verhagen, H.J.

    2015-01-01

    Quantifying the penetration depth of a dragging anchor on a horizontal layer of rockfill provides the possibility to optimize the layer thickness of rockfill layers with a protective function. Current research on this subject is limited and is often aimed at anchor capacities in sand and clay.

  2. Stone anchors along the coast of Chilika Lake: New light on the maritime activities of Orissa, India

    Digital Repository Service at National Institute of Oceanography (India)

    Tripati, S.; Patnaik, A.P.

    and effec- tiveness of the anchors can be taken into account in rela- tion to the environment and nature of the lakebed. The reason for finding hero stones along with anchors could be that some naval battles were fought in the region, and hero stones were...

  3. Anchors from Goa waters, central west coast of India: Remains of Goa's overseas trade contacts with Arabian countries and Portugal

    Digital Repository Service at National Institute of Oceanography (India)

    Tripati, S.; Gaur, A.S.; Sundaresh

    of the samples; Shri S.N. Bandodker for photographs; Shri S.B. Chitari for drawings and Shri Anthony Estrocia sports diver of Goa for donating a stone anchor to NIO. References Athiyaman,N.,2001,Stone anchors from east coast of India a...

  4. Intralesional triamcinolone acetonide injection in hypertrophic skin surrounding the percutaneous titanium implant of a bone-anchored hearing aid.

    NARCIS (Netherlands)

    Rijswijk, JB Van; Mylanus, E.A.M.

    2008-01-01

    OBJECTIVE: We present a patient with persistent hypertrophic skin surrounding the percutaneous implant of a bone-anchored hearing aid system, successfully treated with intralesional applied corticosteroids. METHOD: Case report and review of the world literature concerning bone-anchored hearing aid

  5. Experimental design to measure the anchoring energy on substrate surface by using the alternating-current bridge

    International Nuclear Information System (INIS)

    Hao Hui-Ming; Liu Yao-Yao; Zhang Ping; Zhu Ji-Liang; Ye Wen-Jiang; Cai Ming-Lei; Wang Xiao-Yan

    2017-01-01

    The anchoring property of the substrate surface of liquid crystal cells plays an important role in display and nondisplay fields. This property directly affects the deformation of liquid crystal molecules to change the phase difference through liquid crystal cells. In this paper, a test method based on the alternating-current bridge is proposed to determine the capacitance of liquid crystal cells and thus measure the anchoring energy of the substrate surface. The anchoring energy can be obtained by comparing the capacitance–voltage curves of twisted nematic liquid crystal cells with different anchoring properties in experimental and theoretical results simulated on the basis of Frank elastic theory. Compared with the other methods to determine the anchoring energy, our proposed method requires a simple treatment of liquid crystal cells and allows easy and high-accuracy measurements, thereby expanding the test ideas on the performance parameters of liquid crystal devices. (paper)

  6. Weighing the Benefits of Anchored Math Instruction for Students with Disabilities in General Education Classes.

    Science.gov (United States)

    Bottge, Brian A.; Heinrichs, Mary; Mehta, Zara Dee; Hung, Ya-Hui

    2002-01-01

    A study examined the effectiveness of enhanced anchor instruction and traditional problem instruction in improving the problem-solving performance of 42 seventh-graders with and without disabilities in inclusive classrooms. Students without disabilities profited from contextualized instruction, but benefits for the students with disabilities were…

  7. 78 FR 45104 - Model Manufactured Home Installation Standards: Ground Anchor Installations

    Science.gov (United States)

    2013-07-26

    ... rule, including prevented property damage, personal injury, and loss of life are expected to exceed the... or tie-down failure.'' Similarly, the failure of ground anchor systems also results in collateral property damage to nearby buildings and throughout the community. According to Krigger, \\2\\ 11 percent of...

  8. Comparing topic coverage in breadth-first and depth-first crawls using anchor texts

    NARCIS (Netherlands)

    Samar, Thaer; Traub, Myriam C.; van Ossenbruggen, Jacco; de Vries, Arjen P.

    2016-01-01

    Web archives preserve the fast changing Web by repeatedly crawling its content. The crawling strategy has an influence on the data that is archived. We use link anchor text of two Web crawls created with different crawling strategies in order to compare their coverage of past popular topics. One of

  9. Interpreting the Third International Mathematics and Science Study (TIMSS) achievement scales using scale anchoring

    Science.gov (United States)

    Kelly, Dana L.

    1999-11-01

    The scale anchoring method was used to analyze and describe the TIMSS primary and middle school (Populations 1 and 2) mathematics and science achievement scales. Scale anchoring is a way of attaching meaning to a scale by describing what students know and can do at specific points on the scale. Student achievement was scrutinized at four points on the TIMSS primary and middle school achievement scales---the 25th, 50th, 75th, and 90th international percentiles for fourth and eighth grades. The scale anchoring method was adapted for the TIMSS data and items that students scoring at each of the four scale points were likely to answer correctly (with a 65 percent probability) were identified. The items were assembled in binders organized by anchor level and content area. Two ten-member panels of subject-matter specialists were convened to scrutinize the items, draft descriptions of student proficiency at the four scale points, and identify example TIMSS items to illustrate performance at each level. Following the panel meetings, the descriptions were refined through an iterative review process. The result is a content-referenced interpretation of the TIMSS scales through which TIMSS achievement results can be better communicated and understood.

  10. Using Anchoring Vignettes to Adjust Self-Reported Personality: A Comparison Between Countries

    Directory of Open Access Journals (Sweden)

    Selina Weiss

    2018-03-01

    Full Text Available Data from self-report tools cannot be readily compared between cultures due to culturally specific ways of using a response scale. As such, anchoring vignettes have been proposed as a suitable methodology for correcting against this difference. We developed anchoring vignettes for the Big Five Inventory-44 (BFI-44 to supplement its Likert-type response options. Based on two samples (Rwanda: n = 423; Philippines: n = 143, we evaluated the psychometric properties of the measure both before and after applying the anchoring vignette adjustment. Results show that adjusted scores had better measurement properties, including improved reliability and a more orthogonal correlational structure, relative to scores based on the original Likert scale. Correlations of the Big Five Personality Factors with life satisfaction were essentially unchanged after the vignette-adjustment while correlations with counterproductive were noticeably lower. Overall, these changed findings suggest that the use of anchoring vignette methodology improves the cross-cultural comparability of self-reported personality, a finding of potential interest to the field of global workforce research and development as well as educational policymakers.

  11. Progress on Poverty? New Estimates of Historical Trends Using an Anchored Supplemental Poverty Measure.

    Science.gov (United States)

    Wimer, Christopher; Fox, Liana; Garfinkel, Irwin; Kaushal, Neeraj; Waldfogel, Jane

    2016-08-01

    This study examines historical trends in poverty using an anchored version of the U.S. Census Bureau's recently developed Research Supplemental Poverty Measure (SPM) estimated back to 1967. Although the SPM is estimated each year using a quasi-relative poverty threshold that varies over time with changes in families' expenditures on a core basket of goods and services, this study explores trends in poverty using an absolute, or anchored, SPM threshold. We believe the anchored measure offers two advantages. First, setting the threshold at the SPM's 2012 levels and estimating it back to 1967, adjusted only for changes in prices, is more directly comparable to the approach taken in official poverty statistics. Second, it allows for a better accounting of the roles that social policy, the labor market, and changing demographics play in trends in poverty rates over time, given that changes in the threshold are held constant. Results indicate that unlike official statistics that have shown poverty rates to be fairly flat since the 1960s, poverty rates have dropped by 40 % when measured using a historical anchored SPM over the same period. Results obtained from comparing poverty rates using a pretax/pretransfer measure of resources versus a post-tax/post-transfer measure of resources further show that government policies, not market incomes, are driving the declines observed over time.

  12. Progress on Poverty? New Estimates of Historical Trends Using an Anchored Supplemental Poverty Measure

    Science.gov (United States)

    Wimer, Christopher; Fox, Liana; Garfinkel, Irwin; Kaushal, Neeraj; Waldfogel, Jane

    2016-01-01

    This study examines historical trends in poverty using an anchored version of the U.S. Census Bureau’s recently developed Research Supplemental Poverty Measure (SPM) estimated back to 1967. Although the SPM is estimated each year using a quasi-relative poverty threshold that varies over time with changes in families’ expenditures on a core basket of goods and services, this study explores trends in poverty using an absolute, or anchored, SPM threshold. We believe the anchored measure offers two advantages. First, setting the threshold at the SPM’s 2012 levels and estimating it back to 1967, adjusted only for changes in prices, is more directly comparable to the approach taken in official poverty statistics. Second, it allows for a better accounting of the roles that social policy, the labor market, and changing demographics play in trends in poverty rates over time, given that changes in the threshold are held constant. Results indicate that unlike official statistics that have shown poverty rates to be fairly flat since the 1960s, poverty rates have dropped by 40 % when measured using a historical anchored SPM over the same period. Results obtained from comparing poverty rates using a pretax/pretransfer measure of resources versus a posttax/posttransfer measure of resources further show that government policies, not market incomes, are driving the declines observed over time. PMID:27352076

  13. Arthroscopic double-row suture anchor fixation of minimally displaced greater tuberosity fractures.

    Science.gov (United States)

    Ji, Jong-Hun; Kim, Weon-Yoo; Ra, Ki-Hang

    2007-10-01

    In cases of displaced greater tuberosity fractures, treatments by arthroscopic-assisted reduction and percutaneous screw fixation have been reported. However, in cases in which there is a comminuted fracture or a minimally displaced fracture combined with concomitant lesions such as rotator cuff tear or labral pathology, it is difficult to reduce the fracture and to treat other pathologies by use of a percutaneous screw. Recently, many surgeons have used the double-row repair method in rotator cuff repair, which provides a tendon-bone interface better suited for biologic healing and restoring normal anatomy. In accordance with this method, we used the arthroscopic technique of double-row suture anchor fixation for a minimally displaced greater tuberosity fracture without additional incision. Initially, debridement was performed on the fracture surface by use of a shaver, and the medial-row anchor was inserted through the anterior portal or the intact cuff. Two lateral-row anchors were inserted just anterior and posterior to the lower margin of the fractured fragment under C-arm guidance. The medial-row sutures and lateral-row sutures were then placed. Arthroscopic double-row suture anchor fixation of a displaced greater tuberosity fracture restores the original footprint of the rotator cuff and normal tendon-bone interface of the displaced greater tuberosity fracture.

  14. Test Equating under the NEAT Design: A Necessary Condition for Anchor Items

    Science.gov (United States)

    Raykov, Tenko

    2010-01-01

    Mroch, Suh, Kane, & Ripkey (2009); Suh, Mroch, Kane, & Ripkey (2009); and Kane, Mroch, Suh, & Ripkey (2009) provided elucidating discussions on critical properties of linear equating methods under the nonequivalent groups with anchor test (NEAT) design. In this popular equating design, two test forms are administered to different…

  15. Reducing probabilistic weather forecasts to the worst-case scenario: anchoring effects.

    Science.gov (United States)

    Joslyn, Susan; Savelli, Sonia; Nadav-Greenberg, Limor

    2011-12-01

    Many weather forecast providers believe that forecast uncertainty in the form of the worst-case scenario would be useful for general public end users. We tested this suggestion in 4 studies using realistic weather-related decision tasks involving high winds and low temperatures. College undergraduates, given the statistical equivalent of the worst-case scenario (1 boundary of the 80% predictive interval), demonstrated biased understanding of future weather conditions compared with those given both bounds or no uncertainty information. We argue that this was due to an anchoring effect on numeric estimates, which were closer to the worst-case scenario than was warranted and increased linearly as the anchor became more extreme. In many situations tested here, anchoring in numeric estimates also extended to subsequent binary decisions, leading participants with the worst-case scenario to take action more often than did other participants. These results suggest that worst-case scenario forecasts can mislead the user. They appear to convince people that wind speeds will be higher and temperatures will be lower than what are indicated by the forecast. In addition, participants systematically "corrected" the forecast they were given. This effect was most prominent in the condition in which no uncertainty was provided, suggesting that people feel compelled to take uncertainty into account, even when it is not acknowledged by the forecast. Both the anchoring and correction biases were least evident when both bounds were provided, suggesting that balanced uncertainty leads to the best understanding of future weather conditions.

  16. The ACS Exams Institute Undergraduate Chemistry Anchoring Concepts Content Map III: Inorganic Chemistry

    Science.gov (United States)

    Marek, Keith A.; Raker, Jeffery R.; Holme, Thomas A.; Murphy, Kristen L.

    2018-01-01

    For the past eight years, the ACS Examinations Institute has been developing Anchoring Concepts Content Maps for the different subdisciplines taught throughout the undergraduate curriculum. The structure of the map consists of two top levels that are shared throughout the entire curriculum and two subdiscipline specific levels that contain…

  17. Dynamic Rewiring of Promoter-Anchored Chromatin Loops during Adipocyte Differentiation

    DEFF Research Database (Denmark)

    Siersbæk, Rasmus; Madsen, Jesper Grud Skat; Javierre, Biola Maria

    2017-01-01

    -C to demonstrate a rapid reorganization of promoter-anchored chromatin loops within 4 hr after inducing differentiation of 3T3-L1 preadipocytes. The establishment of new promoter-enhancer loops is tightly coupled to activation of poised (histone H3 lysine 4 mono- and dimethylated) enhancers, as evidenced...

  18. Design method of redundancy of brace-anchor sharing supporting based on cooperative deformation

    Science.gov (United States)

    Liu, Jun-yan; Li, Bing; Liu, Yan; Cai, Shan-bing

    2017-11-01

    Because of the complicated environment requirement, the support form of foundation pit is diversified, and the brace-anchor sharing support is widely used. However, the research on the force deformation characteristics and the related aspects of the cooperative response of the brace-anchor sharing support is insufficient. The application of redundancy theory in structural engineering has been more mature, but there is little theoretical research on redundancy theory in underground engineering. Based on the idea of collaborative deformation, the paper calculates the ratio of the redundancy degree of the cooperative deformation by using the local reinforcement design method and the structural component redundancy parameter calculation formula based on Frangopol. Combined with the engineering case, through the calculation of the ratio of cooperative deformation redundancy in the joint of brace-anchor sharing support. This paper explores the optimal anchor distribution form under the condition of cooperative deformation, and through the analysis and research of displacement field and stress field, the results of the collaborative deformation are validated by comparing the field monitoring data. It provides theoretical basis for the design of this kind of foundation pit in the future.

  19. Effects of Thinking Style and Spatial Ability on Anchoring Behavior in Geographic Information Systems

    Science.gov (United States)

    Wang, Dai-Yi; Lee, Mei-Hsuan; Sun, Chuen-Tsai

    2013-01-01

    The authors propose an instructional use for Google Earth (a GIS application) as an anchoring tool for knowledge integration. Google Earth can be used to support student explorations of world geography based on Wikipedia articles on earth science and history topics. We asked 66 Taiwanese high-school freshmen to make place marks with explanatory…

  20. The Effect of Listener Experience and Anchors on Judgments of Dysphonia

    Science.gov (United States)

    Eadie, Tanya L.; Kapsner-Smith, Mara

    2011-01-01

    Purpose: To determine the effect of auditory anchors on judgments of overall severity (OS) and vocal effort (VE) in dysphonic speech when judgments are made by experienced and inexperienced listeners, and when self-rated by individuals with dysphonia (speaker-listeners). Method: Twenty individuals with dysphonia and 4 normal controls provided…

  1. High-throughput physical map anchoring via BAC-pool sequencing

    Czech Academy of Sciences Publication Activity Database

    Cviková, Kateřina; Cattonaro, F.; Alaux, M.; Stein, N.; Mayer, K.F.X.; Doležel, Jaroslav; Bartoš, Jan

    2015-01-01

    Roč. 15, APR 11 (2015) ISSN 1471-2229 R&D Projects: GA ČR GA13-08786S; GA MŠk(CZ) LO1204 Institutional support: RVO:61389030 Keywords : Physical map * Contig anchoring * Next generation sequencing Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 3.631, year: 2015

  2. Employees’ work engagement and job commitment: The moderating role of career anchors

    Directory of Open Access Journals (Sweden)

    Melinde Coetzee

    2014-08-01

    Research purpose: The objective of the present study was to assess whether individuals’career anchors (measured by the career orientations inventory significantly moderate therelationship between their work engagement (measured by the Utrecht work engagementscale and job commitment (measured by the organisation-related commitment scale. Motivation for the study: Although the literature review suggests that people’s workengagement and job commitment may be influenced by their career anchors, there seems to bea paucity of research examining the interaction effects between these three variables. Research approach, design and method: A cross-sectional quantitative survey approach wasused. A non-probability purposive sample of adults (N = 318 employed in a human resourcecapacity in the South African service industry participated in the study. Stepwise hierarchicalmoderated regression analysis was performed to achieve the objective of the study. Main findings: The results showed that the work engagement-job commitment relationshipwas generally stronger for high career anchor preferences than for low career anchorpreferences.Practical/managerial implications: The results of the study can be useful when human resourceinterventions for enhancing employees’ engagement and commitment are developed. Contribution: The results of the study add new insights to the career literature by showing thatpeople’s career self-concepts (as reflected by their career anchors are important to consider inenhancing their work engagement and job commitment.

  3. Facilitating the Interpretation of English Language Proficiency Scores: Combining Scale Anchoring and Test Score Mapping Methodologies

    Science.gov (United States)

    Powers, Donald; Schedl, Mary; Papageorgiou, Spiros

    2017-01-01

    The aim of this study was to develop, for the benefit of both test takers and test score users, enhanced "TOEFL ITP"® test score reports that go beyond the simple numerical scores that are currently reported. To do so, we applied traditional scale anchoring (proficiency scaling) to item difficulty data in order to develop performance…

  4. Biosynthesis of GPI-anchored proteins: special emphasis on GPI lipid remodeling

    Science.gov (United States)

    Kinoshita, Taroh; Fujita, Morihisa

    2016-01-01

    Glycosylphosphatidylinositols (GPIs) act as membrane anchors of many eukaryotic cell surface proteins. GPIs in various organisms have a common backbone consisting of ethanolamine phosphate (EtNP), three mannoses (Mans), one non-N-acetylated glucosamine, and inositol phospholipid, whose structure is EtNP-6Manα-2Manα-6Manα-4GlNα-6myoinositol-P-lipid. The lipid part is either phosphatidylinositol of diacyl or 1-alkyl-2-acyl form, or inositol phosphoceramide. GPIs are attached to proteins via an amide bond between the C-terminal carboxyl group and an amino group of EtNP. Fatty chains of inositol phospholipids are inserted into the outer leaflet of the plasma membrane. More than 150 different human proteins are GPI anchored, whose functions include enzymes, adhesion molecules, receptors, protease inhibitors, transcytotic transporters, and complement regulators. GPI modification imparts proteins with unique characteristics, such as association with membrane microdomains or rafts, transient homodimerization, release from the membrane by cleavage in the GPI moiety, and apical sorting in polarized cells. GPI anchoring is essential for mammalian embryogenesis, development, neurogenesis, fertilization, and immune system. Mutations in genes involved in remodeling of the GPI lipid moiety cause human diseases characterized by neurological abnormalities. Yeast Saccharomyces cerevisiae has >60 GPI-anchored proteins (GPI-APs). GPI is essential for growth of yeast. In this review, we discuss biosynthesis of GPI-APs in mammalian cells and yeast with emphasis on the lipid moiety. PMID:26563290

  5. Enhanced MRI T 2 Relaxivity in Contrast-Probed Anchor-Free PEGylated Iron Oxide Nanoparticles

    Science.gov (United States)

    Thapa, Bibek; Diaz-Diestra, Daysi; Beltran-Huarac, Juan; Weiner, Brad R.; Morell, Gerardo

    2017-04-01

    Superparamagnetic iron oxide nanoparticles (SPIONs, 11-nm cores) were PEGylated without anchoring groups and studied as efficient MRI T 2 contrast agents (CAs). The ether group of PEG is efficiently and directly linked to the positively charged surface of SPIONs, and mediated through a dipole-cation covalent interaction. Anchor-free PEG-SPIONs exhibit a spin-spin relaxivity of 123 ± 6 mM-1s-1, which is higher than those of PEG-SPIONs anchored with intermediate biomolecules, iron oxide nanoworms, or Feridex. They do not induce a toxic response for Fe concentrations below 2.5 mM, as tested on four different cell lines with and without an external magnetic field. Magnetic resonance phantom imaging studies show that anchor-free PEG-SPIONs produce a significant contrast in the range of 0.1-0.4 [Fe] mM. Our findings reveal that the PEG molecules attached to the cores immobilize water molecules in large regions of 85 nm, which would lead to blood half-life of a few tens of minutes. This piece of research represents a step forward in the development of next-generation CAs for nascent-stage cancer detection.

  6. A systematic evaluation of protein kinase a-a-kinase anchoring protein interaction motifs

    NARCIS (Netherlands)

    Burgers, Pepijn P|info:eu-repo/dai/nl/341566551; van der Heyden, Marcel A G; Kok, Bart; Heck, Albert J R|info:eu-repo/dai/nl/105189332; Scholten, Arjen|info:eu-repo/dai/nl/313939780

    2015-01-01

    Protein kinase A (PKA) in vertebrates is localized to specific locations in the cell via A-kinase anchoring proteins (AKAPs). The regulatory subunits of the four PKA isoforms (RIα, RIβ, RIIα, and RIIβ) each form a homodimer, and their dimerization domain interacts with a small helical region present

  7. A systematic evaluation of protein kinase A-A-kinase anchoring protein interaction motifs

    NARCIS (Netherlands)

    Burgers, Pepijn P; van der Heyden, MAG; Kok, Bart; Heck, Albert J R; Scholten, Arjen

    2015-01-01

    Protein kinase A (PKA) in vertebrates is localized to specific locations in the cell via A-kinase anchoring proteins (AKAPs). The regulatory subunits of the four PKA isoforms (RIα, RIβ, RIIα, and RIIβ) each form a homodimer, and their dimerization domain interacts with a small helical region present

  8. Side-chain-anchored N(alpha)-Fmoc-Tyr-OPfp for bidirectional solid-phase synthesis

    DEFF Research Database (Denmark)

    Olsen, Christian A; Jørgensen, Malene; Hansen, Steen H

    2005-01-01

    [reaction: see text] A mild resin-immobilization strategy employing a readily prepared trityl bromide resin for anchoring building blocks via a phenol group has been developed. With N(alpha)-Fmoc-Tyr-OPfp as a starter building block, it was possible to prepare asymmetrically substituted hybrids o...

  9. Anchor-based classification and type-C inhibitors for tyrosine kinases

    Science.gov (United States)

    Hsu, Kai-Cheng; Sung, Tzu-Ying; Lin, Chih-Ta; Chiu, Yi-Yuan; Hsu, John T.-A.; Hung, Hui-Chen; Sun, Chung-Ming; Barve, Indrajeet; Chen, Wen-Liang; Huang, Wen-Chien; Huang, Chin-Ting; Chen, Chun-Hwa; Yang, Jinn-Moon

    2015-01-01

    Tyrosine kinases regulate various biological processes and are drug targets for cancers. At present, the design of selective and anti-resistant inhibitors of kinases is an emergent task. Here, we inferred specific site-moiety maps containing two specific anchors to uncover a new binding pocket in the C-terminal hinge region by docking 4,680 kinase inhibitors into 51 protein kinases, and this finding provides an opportunity for the development of kinase inhibitors with high selectivity and anti-drug resistance. We present an anchor-based classification for tyrosine kinases and discover two type-C inhibitors, namely rosmarinic acid (RA) and EGCG, which occupy two and one specific anchors, respectively, by screening 118,759 natural compounds. Our profiling reveals that RA and EGCG selectively inhibit 3% (EGFR and SYK) and 14% of 64 kinases, respectively. According to the guide of our anchor model, we synthesized three RA derivatives with better potency. These type-C inhibitors are able to maintain activities for drug-resistant EGFR and decrease the invasion ability of breast cancer cells. Our results show that the type-C inhibitors occupying a new pocket are promising for cancer treatments due to their kinase selectivity and anti-drug resistance. PMID:26077136

  10. Membrane-anchored Serine Protease Matriptase Is a Trigger of Pulmonary Fibrogenesis

    NARCIS (Netherlands)

    Bardou, Olivier; Menou, Awen; François, Charlène; Duitman, Jan Willem; von der Thüsen, Jan H.; Borie, Raphaël; Sales, Katiuchia Uzzun; Mutze, Kathrin; Castier, Yves; Sage, Edouard; Liu, Ligong; Bugge, Thomas H.; Fairlie, David P.; Königshoff, Mélanie; Crestani, Bruno; Borensztajn, Keren S.

    2016-01-01

    Idiopathic pulmonary fibrosis (IPF) is a devastating disease that remains refractory to current therapies. To characterize the expression and activity of the membrane-anchored serine protease matriptase in IPF in humans and unravel its potential role in human and experimental pulmonary fibrogenesis.

  11. Membrane-anchored serine protease matriptase is a trigger of pulmonary fibrogenesis

    NARCIS (Netherlands)

    Bardou, O. (Olivier); Menou, A. (Awen); François, C. (Charlène); J.W. Duitman (Jan Willem); J. von der Thusen (Jan); Borie, R. (Raphaël); Sales, K.U. (Katiuchia Uzzun); Mutze, K. (Kathrin); Y. Castier (Yves); Sage, E. (Edouard); Liu, L. (Ligong); Bugge, T.H. (Thomas H.); Fairlie, D.P. (David P.); Königshoff, M. (Mélanie); B. Crestani (Bruno); K. Borensztajn (Keren)

    2016-01-01

    textabstractRationale: Idiopathic pulmonary fibrosis (IPF) is a devastating disease that remains refractory to current therapies. Objectives: To characterize the expression and activity of the membrane-anchored serine protease matriptase in IPF in humans and unravel its potential role in human and

  12. The anchoring mechanism of a bluff-body stabilized laminar premixed flame

    KAUST Repository

    Kedia, Kushal S.

    2014-09-01

    The objective of this work is to investigate the mechanism of the laminar premixed flame anchoring near a heat-conducting bluff-body. We use unsteady, fully resolved, two-dimensional simulations with detailed chemical kinetics and species transport for methane-air combustion. No artificial flame anchoring boundary conditions were imposed. Simulations show a shear-layer stabilized flame just downstream of the bluff-body, with a recirculation zone formed by the products of combustion. A steel bluff-body resulted in a slightly larger recirculation zone than a ceramic bluff-body; the size of which grew as the equivalence ratio was decreased. A significant departure from the conventional two-zone flame-structure is shown in the anchoring region. In this region, the reaction zone is associated with a large negative energy convection (directed from products to reactants) resulting in a negative flame-displacement speed. It is shown that the premixed flame anchors at an immediate downstream location near the bluff-body where favorable ignition conditions are established; a region associated with (1) a sufficiently high temperature impacted by the conjugate heat exchange between the heat-conducting bluff-body and the hot reacting flow and (2) a locally maximum stoichiometry characterized by the preferential diffusion effects. © 2014 The Combustion Institute.

  13. Using Anchoring Vignettes to Adjust Self-Reported Personality: A Comparison Between Countries

    Science.gov (United States)

    Weiss, Selina; Roberts, Richard D.

    2018-01-01

    Data from self-report tools cannot be readily compared between cultures due to culturally specific ways of using a response scale. As such, anchoring vignettes have been proposed as a suitable methodology for correcting against this difference. We developed anchoring vignettes for the Big Five Inventory-44 (BFI-44) to supplement its Likert-type response options. Based on two samples (Rwanda: n = 423; Philippines: n = 143), we evaluated the psychometric properties of the measure both before and after applying the anchoring vignette adjustment. Results show that adjusted scores had better measurement properties, including improved reliability and a more orthogonal correlational structure, relative to scores based on the original Likert scale. Correlations of the Big Five Personality Factors with life satisfaction were essentially unchanged after the vignette-adjustment while correlations with counterproductive were noticeably lower. Overall, these changed findings suggest that the use of anchoring vignette methodology improves the cross-cultural comparability of self-reported personality, a finding of potential interest to the field of global workforce research and development as well as educational policymakers. PMID:29593621

  14. Amplatzer Vascular Plug Anchoring Technique to Stabilize the Delivery System for Microcoil Embolization

    International Nuclear Information System (INIS)

    Onozawa, Shiro; Murata, Satoru; Mine, Takahiko; Sugihara, Fumie; Yasui, Daisuke; Kumita, Shin-ichiro

    2016-01-01

    PurposeTo evaluate the feasibility of a novel embolization technique, the Amplatzer vascular plug (AVP) anchoring technique, to stabilize the delivery system for microcoil embolization.Materials and methodsThree patients were enrolled in this study, including two cases of internal iliac artery aneurysms and one case of internal iliac arterial occlusion prior to endovascular aortic repair. An AVP was used in each case for embolization of one target artery, and the AVP was left in place. The AVP detachment wire was then used as an anchor to stabilize the delivery system for microcoil embolization to embolize the second target artery adjacent to the first target artery. The microcatheter for the microcoils was inserted parallel to the AVP detachment wire in the guiding sheath or catheter used for the AVP.ResultsThe AVP anchoring technique was achieved and the microcatheter was easily advanced to the second target artery in all three cases.ConclusionThe AVP anchoring technique was found to be feasible to advance the microcatheter into the neighboring artery of an AVP-embolized artery.

  15. Tritium labelling of a cholesterol amphiphile designed for cell membrane anchoring of proteins.

    Science.gov (United States)

    Schäfer, Balázs; Orbán, Erika; Kele, Zoltán; Tömböly, Csaba

    2015-01-01

    Cell membrane association of proteins can be achieved by the addition of lipid moieties to the polypeptide chain, and such lipid-modified proteins have important biological functions. A class of cell surface proteins contains a complex glycosylphosphatidylinositol (GPI) glycolipid at the C-terminus, and they are accumulated in cholesterol-rich membrane microdomains, that is, lipid rafts. Semisynthetic lipoproteins prepared from recombinant proteins and designed lipids are valuable probes and model systems of the membrane-associated proteins. Because GPI-anchored proteins can be reinserted into the cell membrane with the retention of the biological function, they are appropriate candidates for preparing models via reduction of the structural complexity. A synthetic headgroup was added to the 3β-hydroxyl group of cholesterol, an essential lipid component of rafts, and the resulting cholesterol derivative was used as a simplified GPI mimetic. In order to quantitate the membrane integrated GPI mimetic after the exogenous addition to live cells, a tritium labelled cholesterol anchor was prepared. The radioactive label was introduced into the headgroup, and the radiolabelled GPI mimetic anchor was obtained with a specific activity of 1.37 TBq/mmol. The headgroup labelled cholesterol derivative was applied to demonstrate the sensitive detection of the cell membrane association of the anchor under in vivo conditions. Copyright © 2015 John Wiley & Sons, Ltd.

  16. Anchoring to determine negotiated catch limits: a case study of an ...

    African Journals Online (AJOL)

    Despite refinement in scientific methods of setting total allowable catches (TACs), the choice of values is affected by uncertainty that arises as a result of incomplete information and the behavioural intentions of resource users, among others. In this context, this paper promotes 'anchoring' – which is a subject of behavioural ...

  17. Hearing rehabilitation in Treacher Collins Syndrome with bone anchored hearing aid

    Directory of Open Access Journals (Sweden)

    José Fernando Polanski

    2015-12-01

    Full Text Available Objective: To describe a case of hearing rehabilitation with bone anchored hearing aid in a patient with Treacher Collins syndrome. Case description: 3 years old patient, male, with Treacher Collins syndrome and severe complications due to the syndrome, mostly related to the upper airway and hearing. He had bilateral atresia of external auditory canals, and malformation of the pinna. The initial hearing rehabilitation was with bone vibration arch, but there was poor acceptance due the discomfort caused by skull compression. It was prescribed a model of bone-anchored hearing aid, in soft band format. The results were evaluated through behavioral hearing tests and questionnaires Meaningful Use of Speech Scale (MUSS and Infant-Toddler Meaningful Auditory Integration Scale (IT-MAIS. Comments: The patient had a higher acceptance of the bone-anchored hearing aid compared to the traditional bone vibration arch. Audiological tests and the speech and auditory skills assessments also showed better communication and hearing outcomes. The bone-anchored hearing aid is a good option in hearing rehabilitation in this syndrome.

  18. Hearing rehabilitation in Treacher Collins Syndrome with bone anchored hearing aid

    Science.gov (United States)

    Polanski, José Fernando; Plawiak, Anna Clara; Ribas, Angela

    2015-01-01

    Objective: To describe a case of hearing rehabilitation with bone anchored hearing aid in a patient with Treacher Collins syndrome. Case description: 3 years old patient, male, with Treacher Collins syndrome and severe complications due to the syndrome, mostly related to the upper airway and hearing. He had bilateral atresia of external auditory canals, and malformation of the pinna. The initial hearing rehabilitation was with bone vibration arch, but there was poor acceptance due the discomfort caused by skull compression. It was prescribed a model of bone-anchored hearing aid, in soft band format. The results were evaluated through behavioral hearing tests and questionnaires Meaningful Use of Speech Scale (MUSS) and Infant-Toddler Meaningful Auditory Integration Scale (IT-MAIS). Comments: The patient had a higher acceptance of the bone-anchored hearing aid compared to the traditional bone vibration arch. Audiological tests and the speech and auditory skills assessments also showed better communication and hearing outcomes. The bone-anchored hearing aid is a good option in hearing rehabilitation in this syndrome. PMID:26298651

  19. [Hearing rehabilitation in Treacher Collins Syndrome with bone anchored hearing aid].

    Science.gov (United States)

    Polanski, José Fernando; Plawiak, Anna Clara; Ribas, Angela

    2015-12-01

    To describe a case of hearing rehabilitation with bone anchored hearing aid in a patient with Treacher Collins syndrome. 3 years old patient, male, with Treacher Collins syndrome and severe complications due to the syndrome, mostly related to the upper airway and hearing. He had bilateral atresia of external auditory canals, and malformation of the pinna. The initial hearing rehabilitation was with bone vibration arch, but there was poor acceptance due the discomfort caused by skull compression. It was prescribed a model of bone-anchored hearing aid, in soft band format. The results were evaluated through behavioral hearing tests and questionnaires Meaningful Use of Speech Scale (Muss) and Infant-Toddler Meaningful Auditory Integration Scale (IT-Mais). The patient had a higher acceptance of the bone-anchored hearing aid compared to the traditional bone vibration arch. Audiological tests and the speech and auditory skills assessments also showed better communication and hearing outcomes. The bone-anchored hearing aid is a good option in hearing rehabilitation in this syndrome. Copyright © 2015 Sociedade de Pediatria de São Paulo. Publicado por Elsevier Editora Ltda. All rights reserved.

  20. Unusual complication following trauma to a bone-anchored hearing aid: case report and literature review.

    Science.gov (United States)

    McDermott, A-L; Barraclough, J; Reid, A P

    2009-03-01

    We report the second published case of a child with a serious traumatic injury involving the fixture and abutment of their bone-anchored hearing aid. Case reports and review of the world literature concerning unusual complications following trauma to bone-anchored hearing aids. A nine-year-old girl with Dubowitz syndrome sustained an intrusion injury of her bone-anchored hearing aid fixture and abutment following a fall. No other injury was sustained, and there was no neurological complication. The patient underwent immediate removal of the implant and subsequently made a full recovery. Such serious and unusual complications are fortunately very rare. On review of the literature, four cases of similar complications were identified. Only one involved a traumatic injury in a child. Provision of bone-anchored hearing aids involves many clinicians. All clinicians involved in this procedure must be aware of the need to monitor their patients carefully, and to remember that unusual and unexpected complications, although rare, do happen. The patient's need for care continues long after the surgery is complete.

  1. The bone-anchored hearing aid in patients with a unilateral air-bone gap.

    NARCIS (Netherlands)

    Snik, A.F.M.; Mylanus, E.A.M.; Cremers, C.W.R.J.

    2002-01-01

    OBJECTIVES: To study the benefit of the application of a bone-anchored hearing aid in patients with a unilateral air-bone gap. STUDY DESIGN: Prospective evaluation in eight patients. METHODS: Binaural hearing was assessed in the sound field by comparing aided and unaided scores obtained with a sound

  2. Bone-anchored hearing aids and unilateral sensorineural hearing loss: why do patients reject them?

    Science.gov (United States)

    Siau, D; Dhillon, B; Andrews, R; Green, K M J

    2015-04-01

    This study aimed to report the bone-anchored hearing aid uptake and the reasons for their rejection by unilateral sensorineural deafness patients. A retrospective review of 90 consecutive unilateral sensorineural deafness patients referred to the Greater Manchester Bone-Anchored Hearing Aid Programme between September 2008 and August 2011 was performed. In all, 79 (87.8 per cent) were deemed audiologically suitable: 24 (30.3 per cent) eventually had a bone-anchored hearing aid implanted and 55 (69.6 per cent) patients declined. Of those who declined, 26 (47.3 per cent) cited perceived limited benefits, 18 (32.7 per cent) cited reservations regarding surgery, 13 (23.6 per cent) preferred a wireless contralateral routing of sound device and 12 (21.8 per cent) cited cosmetic reasons. In all, 32 (40.5 per cent) suitable patients eventually chose the wireless contralateral routing of sound device. The uptake rate was 30 per cent for audiologically suitable patients. Almost half of suitable patients did not perceive a sufficient benefit to proceed to device implantation and a significant proportion rejected it. It is therefore important that clinicians do not to rush to implant all unilateral sensorineural hearing loss patients with a bone-anchored hearing aid.

  3. Fracture resistance of reattached incisor fragments with mini fibre-reinforced composite anchors.

    NARCIS (Netherlands)

    Fennis, W.M.M.; Kreulen, C.M.; Wolke, J.G.C.; Fokkinga, W.A.; Machado, C.; Creugers, N.H.J.

    2009-01-01

    OBJECTIVES: Fractured coronal fragments of incisors can be adhered to the remaining tooth with resin composite, but are prone to failure. This study explores whether mini fibre-reinforced composite (FRC) anchors increase fracture resistance of reattached fragments. METHODS: Forty-five extracted

  4. Bearing Capacity Analyses for the Great Belt East Bridge Anchor Blocks

    DEFF Research Database (Denmark)

    Sørensen, Carsten Steen; Clausen, Carl J. Frimann; Andersen, Henrik

    1993-01-01

    This paper presents a comparison between different methods of bearing capacity analyses: Upper Bound Method. Limit Equilibrium Analysis and Finite Element Analysis. For the Great Belt East Bridge anchor blocks it was concluded that these methods of calculation agree within 5%. However, for cases...... where the bearing capacity is dominated by frictional materials, much higher differences should be expected....

  5. Solid-phase oligosaccharide synthesis with tris(alkoxy)benzyl amine (BAL) safety-catch anchoring

    DEFF Research Database (Denmark)

    Tolborg, Jakob Fjord; Jensen, Knud Jørgen

    2000-01-01

    A tris(alkoxy)benzylamine (BAL) handle strategy was developed for safety-catch anchoring of D-glucosamine derivatives in solid-phase synthesis of oligosaccharides; the linkage between the BAL handle and the amine proved stable to conc. TFA and Lewis acids, but after N-acylation the amide could...

  6. Making the Work of Anchor Institutions Stick: Building Coalitions and Collective Expertise

    Science.gov (United States)

    Cantor, Nancy; Englot, Peter; Higgins, Marilyn

    2013-01-01

    As more colleges and universities commit to a public mission, it is critical that our work as anchor institutions have a sustainable and positive impact, and that we collaborate fully with the diverse voices and expertise beyond our campuses--the most valuable assets of our multicultural cities. Taking Syracuse, New York, as a microcosm, the…

  7. Amplatzer Vascular Plug Anchoring Technique to Stabilize the Delivery System for Microcoil Embolization

    Energy Technology Data Exchange (ETDEWEB)

    Onozawa, Shiro, E-mail: onozawa@nms.ac.jp; Murata, Satoru, E-mail: genji@nms.ac.jp [Nippon Medical School, Department of Radiology/Center for Advanced Medical Technology (Japan); Mine, Takahiko, E-mail: takahikomine@gmail.com [Tokai University School of Medicine, Department of Radiology, Tokai University Hachioji Hospital (Japan); Sugihara, Fumie, E-mail: giorcubgogo@yahoo.co.jp; Yasui, Daisuke, E-mail: ledhotcp@nms.ac.jp; Kumita, Shin-ichiro, E-mail: s-kumita@nms.ac.jp [Nippon Medical School, Department of Radiology/Center for Advanced Medical Technology (Japan)

    2016-05-15

    PurposeTo evaluate the feasibility of a novel embolization technique, the Amplatzer vascular plug (AVP) anchoring technique, to stabilize the delivery system for microcoil embolization.Materials and methodsThree patients were enrolled in this study, including two cases of internal iliac artery aneurysms and one case of internal iliac arterial occlusion prior to endovascular aortic repair. An AVP was used in each case for embolization of one target artery, and the AVP was left in place. The AVP detachment wire was then used as an anchor to stabilize the delivery system for microcoil embolization to embolize the second target artery adjacent to the first target artery. The microcatheter for the microcoils was inserted parallel to the AVP detachment wire in the guiding sheath or catheter used for the AVP.ResultsThe AVP anchoring technique was achieved and the microcatheter was easily advanced to the second target artery in all three cases.ConclusionThe AVP anchoring technique was found to be feasible to advance the microcatheter into the neighboring artery of an AVP-embolized artery.

  8. Analysis of timber and coating material on an iron anchor recovered off Aguada Bay, Goa

    Digital Repository Service at National Institute of Oceanography (India)

    Tripati, S.; Rao, B.R.; Shashikala, S.; Rao, R.V.; Khedekar, V.D.

    is 4.37 m and is made of two timbers joined together with nine nails (pins) (Figure 3). The thickness of each timber varies from 20 to 30 cm. Inci- dentally the length of the stock is much longer than the anchor. A well-preserved uniform thin layer...

  9. An Indo-Arabian type of stone anchor from Kannur, Kerala,west coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Tripati, S.; Manikfan, A.; Mohamed, M.

    and commerce, cultural contacts and boat and shipbuilding activities of the region. In India, stone anchors have been reported from Gujarat, Maharashtra, Goa, Lakshadweep on the west coast and Tamil Nadu and Orissa on the east coast of India. Recent exploration...

  10. HSV1 MicroRNA Modulation of GPI Anchoring and Downstream Immune Evasion.

    Science.gov (United States)

    Enk, Jonatan; Levi, Assi; Weisblum, Yiska; Yamin, Rachel; Charpak-Amikam, Yoav; Wolf, Dana G; Mandelboim, Ofer

    2016-10-18

    Herpes simplex virus 1 (HSV1) is a ubiquitous human pathogen that utilizes variable mechanisms to evade immune surveillance. The glycosylphosphatidylinositol (GPI) anchoring pathway is a multistep process in which a myriad of different proteins are covalently attached to a GPI moiety to be presented on the cell surface. Among the different GPI-anchored proteins there are many with immunological importance. We present evidence that the HSV1-encoded miR H8 directly targets PIGT, a member of the protein complex that covalently attaches proteins to GPI in the final step of GPI anchoring. This results in a membrane down-modulation of several different immune-related, GPI-anchored proteins, including ligands for natural killer-activating receptors and the prominent viral restriction factor tetherin. Thus, we suggest that by utilizing just one of dozens of miRNAs encoded by HSV1, the virus can counteract the host immune response at several key points. Copyright © 2016 The Author(s). Published by Elsevier Inc. All rights reserved.

  11. Ideal site for ventricular anchoring of artificial chordae in mitral regurgitation.

    Science.gov (United States)

    Weber, Alberto; Hurni, Samuel; Vandenberghe, Stijn; Wahl, Andreas; Aymard, Thierry; Vogel, Rolf; Carrel, Thierry

    2012-04-01

    Surgical treatment of mitral leaflet prolapse using artificial neochordae shows excellent outcomes. Upcoming devices attempt the same treatment in a minimally invasive way but target the left ventricular apex as an anchoring point, rather than the tip of the corresponding papillary muscle. In this study, cine cardiac magnetic resonance imaging was used to compare these 2 different anchoring positions and their dynamic relationship with the mitral leaflets. Eleven healthy volunteers (mean age, 31 years; 6 female; mean ejection fraction, 62%) were examined by cardiac magnetic resonance imaging (3 Tesla, cine steady free precession technique with retrospective gating), whereby dedicated software enabled assessment of the physiologic distances among 3 anchoring sites (anterior papillary muscle, posterior papillary muscle, and apex) and the plane of the mitral annulus at the level of leaflet coaptation. These distances were measured in systole and diastole, and the performance of virtual neochordae was analyzed for the 3 potential anchoring sites. Length difference between systole and diastole for the 3 measured distances were 0.19 ± 0.11 cm (5.9% ± 3.4%) for the anterior papillary muscle, 0.19 ± 0.09 cm (6.7% ± 3.6%) for the posterior papillary muscle, and 1.52 ± 0.18 cm (17.8% ± 2.8%) for the left ventricular apex (P = .001). Virtual neochordae between the leaflet and the left ventricular apex were first adjusted in systole to achieve leaflet coaptation. Leaflet tear in diastole can only be avoided if the width of the attached leaflet is larger than the systole-diastole length difference. On the other hand, if virtual neochordae are adjusted in diastole to avoid leaflet tear, residual leaflet prolapse during systole can result. Because the systole-diastole length difference for papillary muscle anchored chordae is smaller than for apical chordae by a factor 10, there is a strongly reduced risk of prolapse or tearing and the leaflet width is unimportant

  12. A Deformable Generic 3D Model of Haptoral Anchor of Monogenean

    Science.gov (United States)

    Teo, Bee Guan; Dhillon, Sarinder Kaur; Lim, Lee Hong Susan

    2013-01-01

    In this paper, a digital 3D model which allows for visualisation in three dimensions and interactive manipulation is explored as a tool to help us understand the structural morphology and elucidate the functions of morphological structures of fragile microorganisms which defy live studies. We developed a deformable generic 3D model of haptoral anchor of dactylogyridean monogeneans that can subsequently be deformed into different desired anchor shapes by using direct manipulation deformation technique. We used point primitives to construct the rectangular building blocks to develop our deformable 3D model. Point primitives are manually marked on a 2D illustration of an anchor on a Cartesian graph paper and a set of Cartesian coordinates for each point primitive is manually extracted from the graph paper. A Python script is then written in Blender to construct 3D rectangular building blocks based on the Cartesian coordinates. The rectangular building blocks are stacked on top or by the side of each other following their respective Cartesian coordinates of point primitive. More point primitives are added at the sites in the 3D model where more structural variations are likely to occur, in order to generate complex anchor structures. We used Catmull-Clark subdivision surface modifier to smoothen the surface and edge of the generic 3D model to obtain a smoother and more natural 3D shape and antialiasing option to reduce the jagged edges of the 3D model. This deformable generic 3D model can be deformed into different desired 3D anchor shapes through direct manipulation deformation technique by aligning the vertices (pilot points) of the newly developed deformable generic 3D model onto the 2D illustrations of the desired shapes and moving the vertices until the desire 3D shapes are formed. In this generic 3D model all the vertices present are deployed for displacement during deformation. PMID:24204903

  13. Effects of anchoring and arc structure on the control authority of a rail plasma actuator

    International Nuclear Information System (INIS)

    Choi, Young-Joon; Gray, Miles; Sirohi, Jayant; Raja, Laxminarayan L

    2017-01-01

    Experiments were conducted on a rail plasma actuator (RailPAc) with different electrode cross sections (rails or rods) to assess methods to improve the actuation authority, defined as the impulse generated for a given electrical input. The arc was characterized with electrical measurements and high-speed images, while impulse measurements quantified the actuation authority. A RailPAc power supply capable of delivering  ∼1 kA of current at  ∼100 V was connected to rod electrodes (free-floating with circular cross-section) and rail electrodes (flush-mounted in a flat plate with rectangular cross-section). High-speed images show that the rail electrodes cause the arc to anchor itself to the anode electrode and transit in discrete jumps, while rod electrodes permit the arc to transit smoothly without anchoring. The impulse measurements reveal that the anchoring reduces the actuation authority by  ∼21% compared to a smooth transit, and the effect of anchoring can be suppressed by reducing the gap between the rails to 2 mm. The study further demonstrates that if a smooth transit is achieved, the control authority can be increased with a larger gap and larger arc current. In conclusion, the actuation authority of a RailPAc can be maximized by carefully choosing a gap width that prevents anchoring. Further study is warranted to increase the RailPAc actuation authority by introducing multiple turns of wires beneath the RailPAc to augment the induced magnetic field. (paper)

  14. Protein-Anchoring Therapy of Biglycan for Mdx Mouse Model of Duchenne Muscular Dystrophy.

    Science.gov (United States)

    Ito, Mikako; Ehara, Yuka; Li, Jin; Inada, Kosuke; Ohno, Kinji

    2017-05-01

    Duchenne muscular dystrophy (DMD) is a devastating muscle disease caused by loss-of-function mutations in DMD encoding dystrophin. No rational therapy is currently available. Utrophin is a paralog of dystrophin and is highly expressed at the neuromuscular junction. In mdx mice, utrophin is naturally upregulated throughout the muscle fibers, which mitigates muscular dystrophy. Protein-anchoring therapy was previously reported, in which a recombinant extracellular matrix (ECM) protein is delivered to and anchored to a specific target using its proprietary binding domains. Being prompted by a report that intramuscular and intraperitoneal injection of an ECM protein, biglycan, upregulates expression of utrophin and ameliorates muscle pathology in mdx mice, protein-anchoring therapy was applied to mdx mice. Recombinant adeno-associated virus serotype 8 (rAAV8) carrying hBGN encoding human biglycan was intravenously injected into 5-week-old mdx mice. The rAAV8-hBGN treatment improved motor deficits and decreased plasma creatine kinase activities. In muscle sections of treated mice, the number of central myonuclei and the distribution of myofiber sizes were improved. The treated mice increased gene expressions of utrophin and β1-syntrophin, as well as protein expressions of biglycan, utrophin, γ-sarcoglycan, dystrobrevin, and α1-syntrophin. The expression of hBGN in the skeletal muscle of the treated mice was 1.34-fold higher than that of the native mouse Bgn (mBgn). The low transduction efficiency and improved motor functions suggest that biglycan expressed in a small number of muscle fibers was likely to have been secreted and anchored to the cell surface throughout the whole muscular fibers. It is proposed that the protein-anchoring strategy can be applied not only to deficiency of an ECM protein as previously reported, but also to augmentation of a naturally induced ECM protein.

  15. Intranasal immunization with influenza VLPs incorporating membrane-anchored flagellin induces strong heterosubtypic protection.

    Directory of Open Access Journals (Sweden)

    Bao-Zhong Wang

    2010-11-01

    Full Text Available We demonstrated previously that the incorporation of a membrane-anchored form of flagellin into influenza virus-like particles (VLPs improved the immunogenicity of VLPs significantly, inducing partially protective heterosubtypic immunity by intramuscular immunization. Because the efficacy of mucosal vaccination is highly dependent on an adjuvant, and is particularly effective for preventing mucosal infections such as influenza, we determined whether the membrane-anchored flagellin is an efficient adjuvant for VLP vaccines by a mucosal immunization route. We compared the adjuvant effect of membrane-anchored and soluble flagellins for immunization with influenza A/PR8 (H1N1 VLPs by the intranasal route in a mouse model. The results demonstrate that membrane-anchored flagellin is an effective adjuvant for intranasal (IN immunization, inducing enhanced systemic and mucosal antibody responses. High cellular responses were also observed as shown by cytokine production in splenocyte cultures when stimulated with viral antigens. All mice immunized with flagellin-containing VLPs survived challenge with a high lethal dose of homologous virus as well as a high dose heterosubtypic virus challenge (40 LD(50 of A/Philippines/82, H3N2. In contrast, no protection was observed with a standard HA/M1 VLP group upon heterosubtypic challenge. Soluble flagellin exhibited a moderate adjuvant effect when co-administered with VLPs by the mucosal route, as indicated by enhanced systemic and mucosal responses and partial heterosubtypic protection. The membrane-anchored form of flagellin incorporated together with antigen into influenza VLPs is effective as an adjuvant by the mucosal route and unlike standard VLPs, immunization with such chimeric VLPs elicits protective immunity to challenge with a distantly related influenza A virus.

  16. Decay accelerating factor (DAF) is anchored to membranes by a C-terminal glycolipid

    International Nuclear Information System (INIS)

    Medof, M.E.; Haas, R.; Walter, E.I.; Rosenberry, T.L.

    1986-01-01

    Purified 70 kDa membrane (m) DAF incorporates into cells when added in vitro. A 2 kDa smaller DAF form which functions extrinsically like C4bp but is unable to incorporate can be isolated from urine (u). Because of common deficits of mDAF and acetylcholinesterase (AChE) in erythrocytes (E) of patients with paroxysmal nocturnal hemoglobinuria (PNH), mDAF was analyzed for a O-terminal glycolipid membrane anchor similar to that in E AChE. Incubation of E with phosphatidylinositol-specific phospholipase C, an enzyme which cleaves a similar glycolipid anchor in trypanosome variant surface glycoproteins (mfVSGs), released 20% of the DAF antigen. The released DAF species resembled uDAF in size, extrinsic model of C4b2a decay, and lack of hydrophobicity. Reductive radiomethylation of mDAF with [ 14 C]HCHO and NaCNBH 3 revealed ethanolamine and glucosamine in proportions similar to those in the E AChE glycolipid anchor. Papain cleavage of radiomethylated mDAF released the labeled ethanolamine and glucosamine in small O-terminal fragments from the residual DAF that retained N-terminal Asp. Following labeling of the anchors of mDAF and E AChE with the lipophilic photoreagent 3-trifluoromethyl-3-(m-[ 125 I]iodophenyl)diazirine, cleavage at the glucosamine residue by deamination quantitatively released the label from both proteins. Biosynthetic labeling of Hela cells with [ 3 H]ethanolamine resulted in rapid 3 H incorporation into both 48 kDa proDAF and 70 kDa mDAF. These data indicate that mDAF is anchored by a glycolipid similar to that in E AChE, mfVSGs and Thy-1 antigen and raise the possibility that a defect in the assembly or attachment of this structure could account for the deficits of mDAF and E AChE in PNH

  17. Can audiometric results predict qualitative hearing improvements in bone-anchored hearing aid recipients?

    Science.gov (United States)

    McNeil, M L; Gulliver, M; Morris, D P; Makki, F M; Bance, M

    2014-01-01

    Patients receiving a bone-anchored hearing aid have well-documented improvements in their quality of life and audiometric performance. However, the relationship between audiometric measurements and subjective improvement is not well understood. Adult patients enrolled in the Nova Scotia bone-anchored hearing aid programme were identified. The pure tone average for fitting the sound-field threshold, as well as the better and worse hearing ear bone conduction and air conduction levels, were collected pre-operatively. Recipients were asked to complete the Speech, Spatial and Qualities of Hearing questionnaire; their partners were asked to complete a pre- and post-bone anchored hearing aid fitting Hearing Handicap Inventory for Adults questionnaire. Forty-eight patients who completed and returned the Speech, Spatial and Qualities of Hearing questionnaire had partners who completed the Hearing Handicap Inventory for Adults questionnaire. The results from the Speech, Spatial and Qualities of Hearing questionnaire correlated with the sound-field hearing threshold post-bone-anchored hearing aid fitting and the pure tone average of the better hearing ear bone conduction (total Speech, Spatial and Qualities of Hearing Scale to the pre-operative better hearing ear air curve (r = 0.3); worse hearing ear air curve (r = 0.27); post-operative, bone-anchored hearing aid-aided sound-field thresholds (r = 0.35)). An improvement in sound-field threshold correlated only with spatial abilities. In the Hearing Handicap Inventory for Adults questionnaire, there was no correlation between the subjective evaluation of each patient and their partner. The subjective impressions of hearing aid recipients with regards to speech reception and the spatial qualities of hearing correlate well with pre-operative audiometric results. However, the overall magnitude of sound-field improvement predicts an improvement of spatial perception, but not other aspects of hearing, resulting in hearing aid

  18. A deformable generic 3D model of haptoral anchor of Monogenean.

    Directory of Open Access Journals (Sweden)

    Bee Guan Teo

    Full Text Available In this paper, a digital 3D model which allows for visualisation in three dimensions and interactive manipulation is explored as a tool to help us understand the structural morphology and elucidate the functions of morphological structures of fragile microorganisms which defy live studies. We developed a deformable generic 3D model of haptoral anchor of dactylogyridean monogeneans that can subsequently be deformed into different desired anchor shapes by using direct manipulation deformation technique. We used point primitives to construct the rectangular building blocks to develop our deformable 3D model. Point primitives are manually marked on a 2D illustration of an anchor on a Cartesian graph paper and a set of Cartesian coordinates for each point primitive is manually extracted from the graph paper. A Python script is then written in Blender to construct 3D rectangular building blocks based on the Cartesian coordinates. The rectangular building blocks are stacked on top or by the side of each other following their respective Cartesian coordinates of point primitive. More point primitives are added at the sites in the 3D model where more structural variations are likely to occur, in order to generate complex anchor structures. We used Catmull-Clark subdivision surface modifier to smoothen the surface and edge of the generic 3D model to obtain a smoother and more natural 3D shape and antialiasing option to reduce the jagged edges of the 3D model. This deformable generic 3D model can be deformed into different desired 3D anchor shapes through direct manipulation deformation technique by aligning the vertices (pilot points of the newly developed deformable generic 3D model onto the 2D illustrations of the desired shapes and moving the vertices until the desire 3D shapes are formed. In this generic 3D model all the vertices present are deployed for displacement during deformation.

  19. A deformable generic 3D model of haptoral anchor of Monogenean.

    Science.gov (United States)

    Teo, Bee Guan; Dhillon, Sarinder Kaur; Lim, Lee Hong Susan

    2013-01-01

    In this paper, a digital 3D model which allows for visualisation in three dimensions and interactive manipulation is explored as a tool to help us understand the structural morphology and elucidate the functions of morphological structures of fragile microorganisms which defy live studies. We developed a deformable generic 3D model of haptoral anchor of dactylogyridean monogeneans that can subsequently be deformed into different desired anchor shapes by using direct manipulation deformation technique. We used point primitives to construct the rectangular building blocks to develop our deformable 3D model. Point primitives are manually marked on a 2D illustration of an anchor on a Cartesian graph paper and a set of Cartesian coordinates for each point primitive is manually extracted from the graph paper. A Python script is then written in Blender to construct 3D rectangular building blocks based on the Cartesian coordinates. The rectangular building blocks are stacked on top or by the side of each other following their respective Cartesian coordinates of point primitive. More point primitives are added at the sites in the 3D model where more structural variations are likely to occur, in order to generate complex anchor structures. We used Catmull-Clark subdivision surface modifier to smoothen the surface and edge of the generic 3D model to obtain a smoother and more natural 3D shape and antialiasing option to reduce the jagged edges of the 3D model. This deformable generic 3D model can be deformed into different desired 3D anchor shapes through direct manipulation deformation technique by aligning the vertices (pilot points) of the newly developed deformable generic 3D model onto the 2D illustrations of the desired shapes and moving the vertices until the desire 3D shapes are formed. In this generic 3D model all the vertices present are deployed for displacement during deformation.

  20. Examining the Impact of Drifted Polytomous Anchor Items on Test Characteristic Curve (TCC) Linking and IRT True Score Equating. Research Report. ETS RR-12-09

    Science.gov (United States)

    Li, Yanmei

    2012-01-01

    In a common-item (anchor) equating design, the common items should be evaluated for item parameter drift. Drifted items are often removed. For a test that contains mostly dichotomous items and only a small number of polytomous items, removing some drifted polytomous anchor items may result in anchor sets that no longer resemble mini-versions of…

  1. Morphometric quantification of biodegradable PLDLLA-anchor implant-beds on magnetic resonance images of the humeral head

    International Nuclear Information System (INIS)

    Chatterjee, D.

    2009-01-01

    An overview of the functional anatomy of the human shoulder joint is the base for understanding of rotator cuff tears and its surgical repair by means of suture anchors. These anchors, manufactured of biodegradable polymers, do not (or not totally) degrade in the period of time postulated by the manufactures. Bone healing seems to be impaired. Radiological follow-ups of 8 months to years postoperative revealed osteolysis and even cystic deformation of the implant beds (=anchor-holes). In this present study the anchor-holes are morphometrically measured for the first time on MRT-images. For this prospective study MRIs from altogether 38 patients (20 female/18 male, age 43.9a - 81.6a) were selected after arthroscopic rotator cuff repair with 1-4 biodegradable suture anchors (PLDLLA 'Bio-Corkscrews', Arthrex Inc., Naples FL, USA) at a single institution. After signing an informed consent form patients' MRIs could be evaluated after a mean follow-up period of 15.8 and 36 months. The shapes of the bony implant beds were subjectively categorized and for the computer-assisted morphometry of the anchor-hole areas Adobe Photoshop; CS3 Extended (Version 10.0) was used and adapted. The results were statistically analyzed and correlated with the clinical success rate (Constant Score=CS). All anchor-holes were discernable for up to 42 months. A significant shift of threaded to cylindric anchor-hole shapes was evident from the 1 st to 2 nd follow-up. Only 11.5% of the anchor-holes showed a cystic enlargement. At the 1 st follow-up the anchor-hole areas increased on average by 50.87% compared to original anchor size. However, at the 2 nd follow-up all anchor-hole areas decreased significantly (p st follow-up. The average preoperative CS improved from 38.5 points to 87.4 (1 st follow-up) and then remained at 87 points (2 nd follow-up). Anchor-holes of biodegradable suture anchor are, as opposed to the time period claimed by the manufacturers, visible and thus not totally degraded

  2. Controlling the Anchoring Effect through Transcranial Direct Current Stimulation (tDCS to the Right Dorsolateral Prefrontal Cortex

    Directory of Open Access Journals (Sweden)

    Jianbiao Li

    2017-06-01

    Full Text Available Selective accessibility mechanisms indicate that anchoring effects are results of selective retrieval of working memory. Neuroimaging studies have revealed that the right dorsolateral prefrontal cortex (DLPFC is closely related to memory retrieval and performance. However, no research has investigated the effect of changing the cortical excitability in right DLPFC on anchoring effects. Transcranial direct current stimulation (tDCS can modulate the excitability of the human cerebral cortex, while anodal and cathodal tDCS are postulated to increase or decrease cortical activity, respectively. In this study, we used tDCS to investigate whether effects of increased or decreased right DLPFC excitability influence anchoring effects in willingness to pay (WTP experiments. Ninety participants were first randomly assigned to receive either anodal, cathodal, or sham stimulation of 15 min, then they performed a valuation task regarding WTP. The results showed that anchoring effects were negatively related to activities of right DLPFC: the anodal stimulation diminished anchoring effects while the cathodal stimulation increased anchoring effects. These outcomes provide one of the first instances of neural evidence for the role of the right DLPFC in anchoring effects and support psychological explanations of the selective accessibility mechanisms and cognitive sets.

  3. Anchoring Intrinsically Disordered Proteins to Multiple Targets: Lessons from N-Terminus of the p53 Protein

    Directory of Open Access Journals (Sweden)

    Yongqi Huang

    2011-02-01

    Full Text Available Anchor residues, which are deeply buried upon binding, play an important role in protein–protein interactions by providing recognition specificity and facilitating the binding kinetics. Up to now, studies on anchor residues have been focused mainly on ordered proteins. In this study, we investigated anchor residues in intrinsically disordered proteins (IDPs which are flexible in the free state. We identified the anchor residues of the N-terminus of the p53 protein (Glu17–Asn29, abbreviated as p53N which are involved in binding with two different targets (MDM2 and Taz2, and analyzed their side chain conformations in the unbound states. The anchor residues in the unbound p53N were found to frequently sample conformations similar to those observed in the bound complexes (i.e., Phe19, Trp23, and Leu26 in the p53N-MDM2 complex, and Leu22 in the p53N-Taz2 complex. We argue that the bound-like conformations of the anchor residues in the unbound state are important for controlling the specific interactions between IDPs and their targets. Further, we propose a mechanism to account for the binding promiscuity of IDPs in terms of anchor residues and molecular recognition features (MoRFs.

  4. Bone-anchored hearing devices in children with unilateral conductive hearing loss: a patient-carer perspective.

    Science.gov (United States)

    Banga, Rupan; Doshi, Jayesh; Child, Anne; Pendleton, Elizabeth; Reid, Andrew; McDermott, Ann-Louise

    2013-09-01

    We sought to determine the outcome of implantation of a bone-anchored hearing device in children with unilateral conductive hearing loss. A retrospective case note analysis was used in a tertiary referral pediatric hospital to study 17 consecutive cases of pediatric patients with unilateral conductive hearing loss who were fitted with a bone-anchored hearing device between 2005 and 2010. The average age of the patients at the time of bone-anchored hearing device fitting was 10 years 6 months (range, 6 years 3 months to 16 years). Qualitative subjective outcome measures demonstrated benefit. The vast majority of patients reported improved social and physical functioning and improved quality of life. All 17 patients are currently using their bone-anchored hearing device on a daily basis after a follow-up of 6 months. This study has shown improved quality of life in children with unilateral hearing loss after implantation of their bone-anchored hearing device. There was a high degree of patient satisfaction and improvement in health status reported by children and/or carers. Bone-anchored hearing devices have an important role in the management of children with symptomatic unilateral hearing loss. Perhaps earlier consideration of a bone-anchored hearing device would be appropriate in selected cases.

  5. The bone-anchored hearing aid in the rehabilitation of single-sided deafness: experience with 58 patients.

    Science.gov (United States)

    Martin, T P C; Lowther, R; Cooper, H; Holder, R L; Irving, R M; Reid, A P; Proops, D W

    2010-08-01

    To assess the efficacy of the bone-anchored hearing aid (BAHA) in the rehabilitation of single-sided deafness (SSD). Retrospective case-control series review. Tertiary referral unit. Fifty-eight consecutive patients that had a bone-anchored hearing aid for single-sided deafness completed outcome questionnaires, building upon earlier audiological assessment of 19 patients. Single-sided deafness controls (n = 49) were mainly acoustic neuroma patients. speech discrimination testing in directional noise, speech and spatial qualities of hearing questionnaire and the Glasgow Benefit Inventory (GBI). The mean follow-up time was 28.4 months. Five (13%) of the bone-anchored hearing aid patients were non-users because of lack of benefit. The audiometric testing confirmed that when noise was on the bone-anchored hearing aid side speech perception was reduced but benefited when noise was on the side of the hearing ear. There was no difference between the Speech and Spatial Qualities of Hearing Scores in bone-anchored hearing aid users and controls. In particular there was no difference in the spatial subscores. In the bone-anchored hearing aid users the median Glasgow Benefit Inventory score was 11. If the non-users are included then 13 (22%) patients had no or detrimental (negative) Benefit scores. No or negative benefit scores were more frequent in those deaf for bone-anchored hearing aid was most useful in small groups or in 'one-to-one' conversation. Bone-anchored hearing aid rehabilitation for single-sided deafness is less successful than for other indications, reflected here by relatively low median Glasgow Benefit Inventory scores. There was also no significant difference between controls and bone-anchored hearing aid users in the Speech and Spatial Qualities of Hearing Questionnaire. Patients with a longer duration of deafness report greater subjective benefit than those more recently deafened, perhaps due to differing expectations.

  6. Is there loss of vibration amplitude across the snap coupling of the bone-anchored hearing aid?

    Science.gov (United States)

    Majdalawieh, Osama; Van Wijhe, Rene G; Bance, Manohar

    2006-04-01

    There is loss of vibration transmission across the snap coupling connecting the Bone-Anchored Hearing Aid transducer to the implanted abutment on the head. The only nonrigid part of the Bone-Anchored Hearing Aid system is the connection between the output of the transducer and the abutment. Vibration losses across the coupling have not been previously measured. If a loss is found, a change in design could improve the efficiency of the Bone-Anchored Hearing Aid. This would be very helpful in borderline cases in which the Bone-Anchored Hearing Aid does not have enough power to achieve adequate hearing threshold levels. A laser Doppler vibrometer was used to measure vibrations on the output stem and four points on the abutment of the Bone-Anchored Hearing Aid. The Bone-Anchored Hearing Aid was coupled to a dry skull through a plexiglas bite bar screwed to the skull. The impedance load was varied by fixing the skull. A control loose coupling was measured. Five Bone-Anchored Hearing Aid Compacts were measured. There was little loss across the Bone-Anchored Hearing Aid snap coupling. At frequencies above 500 Hz, there was no more than 5-dB loss at any frequency. Changing the impedance load by fixing the skull did not change the loss across the coupling. The snap coupling is an efficient means of transmitting vibrations to the skull. There is little loss of vibration attenuation across it. Increases in functional Bone-Anchored Hearing Aid amplification gain cannot be achieved by further optimizing this interface.

  7. The utilisation of a career conversation framework based on Schein’s career anchors model

    Directory of Open Access Journals (Sweden)

    Magda Bezuidenhout

    2013-01-01

    Full Text Available Orientation: This  study  constituted  and  reported  on  the  outcomes  of  a  structured  career conversation  framework  based  on  Schein’s  eight  career  anchors  in  an  open  distance  and e-learning (ODeL university in South Africa.Research purpose: The purpose of the research was to report on the utilisation of a structured career conversation framework based on Schein’s career anchors model.Motivation for the study: The rationale for the study was the paucity of studies investigating career anchors in South Africa’s multicultural organisational context.Research design, approach and method: A quantitative approach was adopted in the study. The population consisted of 4200 employees at a university in South Africa. Statistical analysis was performed using one-way analysis of variance (ANOVA as well as a Scheffe post hoc test.Main  findings: The  findings  of  this  study  suggest  that  career  conversation  has  a  dynamic nature (i.e. it changes over a period of time. Consequently, career development interventions in the workplace need to approach the workforce holistically.Practical/managerial implications: The findings and results will assist managers, practitioners and  career  development  specialists  in  the  practical  implementation  of  the  career  anchor concept.Contribution/value-add: The career conversation framework based on Schein’s career anchors has expanded the existing theory to find the right balance between career conversations and career anchors to keep people motivated to perform optimally in an organisation.

  8. Constructive and problem-based learning using blended learning anchored instruction approaches

    Science.gov (United States)

    Mayer, M.

    2012-04-01

    Based on an anchored instruction approach, an enriched blended learning lecture course ("Introduction into GNSS positioning") was established in order to enable constructive and problem-based learning. The lecture course "Introduction into GNSS positioning" is a compulsory part of the Bachelor study course "Geodesy and Geoinformatics" and also a supplementary module of the Bachelor study course "Geophysics". Within the lecture course, basic knowledge and basic principles of Global Navigation Satellite Systems, like GPS, are imparted. The presented higher education technique "anchored instruction" uses a real and up-to-date and therefore authentic scientific paper dealing with a recent large-scale geodetic project (Fehmarn Belt Fixed Link) in order to introduce the topic of GNSS-based positioning to the students. In the beginning of the semester, the students have to read the paper individually and carefully. This enables them to realize a lot of not-known GNSS-related facts. Therefore, questions can be formulated focusing on new, unclear or not-understood aspects of the paper. The lecture course deals with these questions, in order to answer them throughout the semester. During the lecture course this paper is referred, e.g., in the middle of the semester, the paper has to be read again in order to check which questions have been answered; in addition, new question arise. At the end of the lecture course, the author of the scientific paper gave a concluding lecture. The framing anchor technique enables the students to anchor their GNSS knowledge. The presented case study uses a teaching resp. learning setting consisting of classroom lectures (given by teachers and learners), practical trainings (e.g., field exercises, students select topics individually), and online lectures (learning management system ILIAS is used as data, result, and asynchronous communication platform). The implementation and the elements of the anchoring technique, which enables student

  9. Bulk chirality effect for symmetric bistable switching of liquid crystals on topologically self-patterned degenerate anchoring surface.

    Science.gov (United States)

    Park, Min-Kyu; Joo, Kyung-Il; Kim, Hak-Rin

    2017-06-26

    We demonstrate a bistable switching liquid crystal (LC) mode utilizing a topologically self-structured dual-groove surface for degenerated easy axes of LC anchoring. In our study, the effect of the bulk elastic distortion of the LC directors on the bistable anchoring surface is theoretically analyzed for balanced bistable states based on a free energy diagram. By adjusting bulk LC chirality, we developed ideally symmetric and stable bistable anchoring and switching properties, which can be driven by a low in-plane pulsed field of about 0.7 V/µm. The fabricated device has a contrast ratio of 196:1.

  10. Dependence of optical phase modulation on anchoring strength of dielectric shield wall surfaces in small liquid crystal pixels

    Science.gov (United States)

    Isomae, Yoshitomo; Shibata, Yosei; Ishinabe, Takahiro; Fujikake, Hideo

    2018-03-01

    We demonstrated that the uniform phase modulation in a pixel can be realized by optimizing the anchoring strength on the walls and the wall width in the dielectric shield wall structure, which is the needed pixel structure for realizing a 1-µm-pitch optical phase modulator. The anchoring force degrades the uniformity of the phase modulation in ON-state pixels, but it also keeps liquid crystals from rotating against the leakage of an electric field. We clarified that the optimal wall width and anchoring strength are 250 nm and less than 10‑4 J/m2, respectively.

  11. Anchoring device enabling relaxation of a multi-strand prestressing cable

    International Nuclear Information System (INIS)

    1979-01-01

    Anchoring device, in a concrete structure, for a multi-strand prestressing cable, enabling the cable to be stressed or relaxed, comprising: (a) an axisymmetrical block, fitted with channels to enable the cable strands to be stressed and anchored through this block, (b) a duct with its opening splayed to a diameter greater than that of the block over a length corresponding to the stretching of the cable when being stressed, (c) a round bearing plate on the concrete around the expanded hole of the duct and (d) at least one intermediate removable bearing piece coming between the edge of the block and the internal edge of the plate. The removable parts are crown sectors of which the opposite bearing faces of each are slanted with respect to the centre line of the block and orientated in the same direction so as to transmit the cable stress at an angle from the block to the edge of the bearing plate [fr

  12. A-Kinase Anchoring Protein-Lbc: A Molecular Scaffold Involved in Cardiac Protection

    Directory of Open Access Journals (Sweden)

    Dario Diviani

    2018-02-01

    Full Text Available Heart failure is a lethal disease that can develop after myocardial infarction, hypertension, or anticancer therapy. In the damaged heart, loss of function is mainly due to cardiomyocyte death and associated cardiac remodeling and fibrosis. In this context, A-kinase anchoring proteins (AKAPs constitute a family of scaffolding proteins that facilitate the spatiotemporal activation of the cyclic adenosine monophosphate (AMP-dependent protein kinase (PKA and other transduction enzymes involved in cardiac remodeling. AKAP-Lbc, a cardiac enriched anchoring protein, has been shown to act as a key coordinator of the activity of signaling pathways involved in cardiac protection and remodeling. This review will summarize and discuss recent advances highlighting the role of the AKAP-Lbc signalosome in orchestrating adaptive responses in the stressed heart.

  13. The Birmingham bone anchored hearing aid programme: paediatric experience and results.

    Science.gov (United States)

    Powell, R H; Burrell, S P; Cooper, H R; Proops, D W

    1996-01-01

    Over a five-year period, 34 patients have been referred to the Birmingham bone anchored hearing aid programme, paediatric section, of who 21 are now wearing the bone anchored hearing aid (BAHA) and four are awaiting surgery for fitting of the BAHA. Of the patients assessed, found to be suitable and who proceeded to surgery for the BAHA, 44 per cent had Treacher Collins syndrome, 28 per cent had bilateral atresia or microtia, 16 per cent had Goldenhaar's syndrome, four per cent (one patient) had branchio-otorenal syndrome and eight per cent had chronic suppurative otitis media. This paper presents objective and subjective data collected from these patients. It is shown that the BAHA is a very effective hearing aid for children with congenital hearing loss.

  14. Predicting the Pullout Capacity of Small Ground Anchors Using Nonlinear Integrated Computing Techniques

    Directory of Open Access Journals (Sweden)

    Mosbeh R. Kaloop

    2017-01-01

    Full Text Available This study investigates predicting the pullout capacity of small ground anchors using nonlinear computing techniques. The input-output prediction model for the nonlinear Hammerstein-Wiener (NHW and delay inputs for the adaptive neurofuzzy inference system (DANFIS are developed and utilized to predict the pullout capacity. The results of the developed models are compared with previous studies that used artificial neural networks and least square support vector machine techniques for the same case study. The in situ data collection and statistical performances are used to evaluate the models performance. Results show that the developed models enhance the precision of predicting the pullout capacity when compared with previous studies. Also, the DANFIS model performance is proven to be better than other models used to detect the pullout capacity of ground anchors.

  15. The Effect of Colour on the Anchoring Heuristic in Consumer Decision Making

    Directory of Open Access Journals (Sweden)

    Sungwon Han

    2014-08-01

    Full Text Available The purpose of our research was to investigate the effect of colour on cognitive processing styles in social decision-making situations. The present research investigated the effect of colour on estimating the price of a gift for a social target. Two colours, blue and red, were provided as environmental cues, and the motivation for a decision was manipulated, by varying the target person’s level of attractiveness in a presentation slide during a gift-purchasing simulation. A blue background with low motivation resulted in the anchoring effect, meaning that participants used heuristic processing. However, for a blue background with high motivation and red backgrounds with both high and low motivational levels, participants were not influenced by any anchoring effect. The results indicated that the effect of colour on cognitive style interacted with the motivational level, the attractiveness of the photo target. The theoretical implications, evolutionary explanation, and ideas for further research are also discussed.

  16. External validity and anchoring heuristics: application of DUNDRUM-1 to secure service gatekeeping in South Wales.

    Science.gov (United States)

    Lawrence, Daniel; Davies, Tracey-Lee; Bagshaw, Ruth; Hewlett, Paul; Taylor, Pamela; Watt, Andrew

    2018-02-01

    Aims and method Structured clinical judgement tools provide scope for the standardisation of forensic service gatekeeping and also allow identification of heuristics in this decision process. The DUNDRUM-1 triage tool was completed retrospectively for 121 first-time referrals to forensic services in South Wales. Fifty were admitted to medium security, 49 to low security and 22 remained in open conditions. DUNDRUM-1 total scores differed appropriately between different levels of security. However, regression revealed heuristic anchoring on the 'legal process' and 'immediacy of risk due to mental disorder' items. Clinical implications Patient placement was broadly aligned with DUNDRUM-1 recommendations. However, not all triage items informed gatekeeping decisions. It remains to be seen whether decisions anchored in this way are effective. Declaration of interest Dr Mark Freestone gave permission for AUC values from Freestone et al. (2015) to be presented here for comparison.

  17. Modifying the Adsorption Characteristic of Inert Silica Films by Inserting Anchoring Sites

    Science.gov (United States)

    Ulrich, Stefan; Nilius, Niklas; Freund, Hans-Joachim; Martinez, Umberto; Giordano, Livia; Pacchioni, Gianfranco

    2009-01-01

    The adsorption properties of thin silica films on Mo(112) have been tailored by embedding single Pd atoms into the nanopores of the oxide material. The embedded Pd is able to anchor metal adatoms that would not bind to the inert silica surface otherwise. Several adsorption structures, e.g., Pd-Pd, Ag-Pd, and Au-Pd complexes, have been prepared in this way and analyzed with the STM and density functional theory. The binding strength of the different adatoms to the surface is determined by the number of electrons in their frontier orbitals, which introduce a repulsive interaction with the oxide electronic states and weaken the covalent bond to the Pd anchor.

  18. Effects of the anchor system on postural control in older Adults

    Directory of Open Access Journals (Sweden)

    Eliane Mauerberg de Castro

    2012-03-01

    Full Text Available Falls are common during aging, and can have drastic consequences. Within this context, maintaining the ability to balance plays an essential role in enabling older adults to continue to perform their daily activities. Therefore, the use of interventional and treatment tools for development of balance becomes essential. The objective of this study was to analyze the anchor system as a potential tool for decreasing body sway in older and young adults. Older adults had more postural sway than their young counterparts. The absence of visual information led to larger instability in both groups. The anchor system improved postural stability of both groups. Thus, it may be a useful tool for posture stabilization in old and young adults.

  19. Communication: Electrical rectification of C{sub 59}N: The role of anchoring and doping sites

    Energy Technology Data Exchange (ETDEWEB)

    Tawfik, Sherif Abdulkader, E-mail: sherif.abbas@sydney.edu.au; Stampfl, C. [School of Physics, The University of Sydney, Sydney, New South Wales 2006 (Australia); Cui, X. Y.; Ringer, S. P. [Australian Centre for Microscopy and Microanalysis, and School of Aerospace, Mechanical and Mechatronic Engineering, The University of Sydney, Sydney, New South Wales 2006 (Australia)

    2016-01-14

    Based on the nonequilibrium Green’s function formalism and density-functional theory, we investigate the onset of electrical rectification in a single C{sub 59}N molecule in conjunction with gold electrodes. Our calculations reveal that rectification is dependent upon the anchoring of the Au atom on C{sub 59}N; when the Au electrode is singly bonded to a C atom (labeled here as A), the system does not exhibit rectification, whereas when the electrode is connected to the C–C bridge site between two hexagonal rings (labeled here as B), transmission asymmetry is observed, where the rectification ratio reaches up to 2.62 at ±1 V depending on the N doping site relative to the anchoring site. Our analysis of the transmission mechanism shows that N doping of the B configuration causes rectification because more transmission channels are available for transmission in the B configuration than in the A configuration.

  20. Effects of molecule anchoring and dispersion on nanoscopic friction under electrochemical control

    International Nuclear Information System (INIS)

    De Wijn, A S; Fasolino, A; Filippov, A E; Urbakh, M

    2016-01-01

    The application of electric fields is a promising strategy for in situ control of friction. While there have recently been many experimental studies on friction under the influence of electric fields, theoretical understanding is very limited. Recently, we introduced a simple theoretical model for friction under electrochemical conditions that focused on the interaction of a force microscope tip with adsorbed molecules whose orientation was dependent on the applied electric field. Here we focus on the effects of anchoring of the molecules on friction. We show that anchoring affects the intensity and width of the peak in the friction that occurs near a reorientation transition of adsorbed molecules, and explain this by comparing the strength of molecule–molecule and molecule–tip interactions. We derive a dispersion relation for phonons in the layer of adsorbed molecules and demonstrate that it can be used to understand important features of the frictional response. (paper)

  1. Nonplanar Organic Sensitizers Featuring a Tetraphenylethene Structure and Double Electron-Withdrawing Anchoring Groups.

    Science.gov (United States)

    Zhang, Fangshuai; Fan, Jie; Yu, Huijuan; Ke, Zhuofeng; Nie, Changming; Kuang, Daibin; Shao, Guang; Su, Chengyong

    2015-09-18

    Two metal-free organic sensitizers containing two N,N-diethylaniline (DEA) moieties and a twisted 1,1,2,2-tetraphenylethene (TPE) structure, dye SD with one anchoring group and dye DD with two anchoring groups, were synthesized and applied in dye-sensitized solar cells (DSSCs). The introduction of a nonplanar TPE structure was used to form a series of propeller-like structures and reduce the tendency of dyes to randomly aggregate on TiO2 surface, but without importing an aggregation-induced emission (AIE) property. The thermal stabilities, UV-vis absorption spectra, electrochemical properties, and photovoltaic parameters of DSSCs with these two dyes were systematically studied and compared with each other. The overall conversion efficiencies (η) of 4.56% for dye SD and 6.08% for dye DD were obtained under AM 1.5 G irradiation.

  2. Subcutaneous anchor attachment increases retention of radio transmitters on Xantus' and marbled murrelets

    Science.gov (United States)

    Newman, Scott H.; Takekawa, John Y.; Whitworth, Darrell L.; Burkett, Esther E.

    1999-01-01

    We modified a subcutaneous anchor attachment and achieved transmitter reten- tion times that exceeded those reported previously for other attachments used on alcids. Traditional suture and epoxy attachment methods were used on Xantus' Murrelets in 1995 and 1996, while the modified attachment was used for Xantus' Murrelets in 1996 and 1997 and Marbled Murrelets in 1997. Modifications included use of an inhalant anesthetic, placing the anchor in a more cranial position on the back, application of marine epoxy, and place- ment of a single subcutaneous non-absorbable suture at the caudal end of the radio to hold the radio in place initially. We located 22 of 56 (39%) Xantus' Murrelets radio-marked using suture and epoxy during aerial surveys in 1995 and 1996. Of birds radio-marked using the subcutaneous anchor attachment, we located 92 of 113 (81%) Xantus' Murrelets marked in 1996 and 1997 and all 28 (100%) Marbled Murrelets marked in 1997 during aerial surveys. The maximum confirmed duration for the subcutaneous anchor transmitter attachment was 51 d for Xantus' Murrelets and 78 d for Marbled Murrelets versus 41 d for the suture and epoxy attachment used on Xantus' Murrelets. Recapture rates of radio-marked Xantus' Mur- relets were similar to recapture rates of unmarked Xantus' Murrelets. Our post-release ob- servations indicated negligible short-term physical effects from the attachment procedure, while telemetry data and examination of recaptured murrelets indicated no evidence of infection or other long-term physical effects. Breeding behavior of some murrelets was not disrupted; however, further evaluation of potential effects of this attachment technique on breeding and behavior is needed.

  3. Innovative CSR: a framework for anchoring corporate social responsibility in the innovation literature

    OpenAIRE

    Preuss, Lutz

    2011-01-01

    Sketching the evolution of corporate social responsibility (CSR) from decoupled corporate philanthropy through strategic CSR to efforts to mainstream CSR throughout the firm, this paper highlights considerable drawbacks of a narrow view of the business case for CSR. Hence it seeks to provide an alternative that is still linked to key business processes but avoids such a tight coupling. The paper argues that this can be achieved through anchoring CSR in the literature on innovation. A definiti...

  4. Load applied on bone-anchored transfemoral prosthesis: Characterization of a prosthesis—A pilot study

    OpenAIRE

    Laurent Frossard, PhD; Eva Häggström, CPO; Kerstin Hagberg, PhD; Rickard Brånemark, MD, PhD

    2013-01-01

    The objectives of this study were to (1) record the inner-prosthesis loading during activities of daily living (ADLs), (2) present a set of variables comparing loading data, and (3) provide an example of characterization of two prostheses. The load was measured at 200 Hz using a multi-axial transducer mounted between the residuum and the knee of an individual with unilateral transfemoral amputation fitted with a bone-anchored prosthesis. The load was measured while using two different prosthe...

  5. Physical and numerical modelling of earth pressure on anchored sheet pile walls in sand

    DEFF Research Database (Denmark)

    Krogsbøll, Anette Susanne; Fuglsang, Leif D

    2006-01-01

    The influence of wall flexibility on earth pressure, bending moments and failure modes is studied. Numerical models are compared to results from model tests carried out in a geotechnical centrifuge. The back-fill is dry sand and failure is introduced by allowing the wall to rotate around the anchor......-model showed the right behaviour in pre-failure as well as failure for both flexible and stiff walls, whereas the MC-model showed some shortcomings when stiff walls were modelled....

  6. Single-incision laparoscopic surgery in a survival animal model using a transabdominal magnetic anchoring system.

    Science.gov (United States)

    Cho, Yong Beom; Park, Chan Ho; Kim, Hee Cheol; Yun, Seong Hyeon; Lee, Woo Yong; Chun, Ho-Kyung

    2011-12-01

    Though single-incision laparoscopic surgery (SILS) can reduce operative scarring and facilitates postoperative recovery, it does have some limitations, such as reduction in instrument working, difficulty in triangulation, and collision of instruments. To overcome these limitations, development of new instruments is needed. The aim of this study is to evaluate the feasibility and safety of a magnetic anchoring system in performing SILS ileocecectomy. Experiments were performed in a living dog model. Five dogs (26.3-29.2 kg) underwent ileocecectomy using a multichannel single port (OCTO port; Darim, Seoul, Korea). The port was inserted at the umbilicus and maintained a CO(2) pneumoperitoneum. Two magnet-fixated vascular clips were attached to the colon using an endoclip applicator, and it was held together across the abdominal wall by using an external handheld magnet. The cecum was then retracted in an upward direction by moving the external handheld magnet, and the mesocolon was dissected with Ultracision(®). Extracorporeal functional end-to-end anastomosis was done using a linear stapler. All animals survived during the observational period of 2 weeks, and then re-exploration was performed under general anesthesia for evaluation of intra-abdominal healing and complications. Mean operation time was 70 min (range 55-100 min), with each subsequent case taking less time. The magnetic anchoring system was effective in achieving adequate exposure in all cases. All animals survived and convalesced normally without evidence of clinical complication during the observation period. At re-exploration, all anastomoses were completely healed and there were no complications such as abscess, bleeding or organ injury. SILS ileocecectomy using a magnetic anchoring system was safe and effective in a dog model. The development of magnetic anchoring systems may be beneficial for overcoming the limitations of SILS.

  7. Anchoring barbs and balloon expandable stents: what is the risk of perforation and failed stent deployment?

    Science.gov (United States)

    Bown, M J; Harrison, G J; How, T V; Brennan, J A; Fisher, R K; Vallabhaneni, S R; McWilliams, R G

    2012-09-01

    Balloon expandable stents may on occasion be deployed in close proximity to the anchoring barbs of endovascular grafts. The aim of this study was to determine the risk and effect of balloon perforation by anchoring barbs and to assess whether these risks are different if the balloon is protected by a covered stent mounted upon it. A bench-top model was developed to mimic the penetration of anchoring barbs into the lumen of medium sized blood vessels. The model allowed variation of angle and depth of vessel penetration. Both bare balloons and those with covered stents mounted upon them were tested in the model to determine whether there was a risk of perforation and which factors increased or decreased this risk. All combinations of barb angle and depth caused balloon perforation but this was most marked when the barb was placed perpendicular to the long axis of the balloon. When the deployment of covered stents was attempted balloon perforation occurred in some cases but full stent deployment was achieved in all cases where the perforation was in the portion of the balloon covered by the stent. The only situation in which stent deployment failed was where the barb was intentionally placed in the uncovered portion of the balloon. This resulted in only partial deployment of the stent. Balloon rupture is a distinct possibility when deploying balloon-expandable stents in close proximity to anchoring barbs. Care should be taken in this circumstance to ensure that the barb is well away from the uncovered portion of the balloon. Copyright © 2012 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.

  8. Physical and numerical modelling of earth pressure on anchored sheet pile walls in sand

    DEFF Research Database (Denmark)

    Krogsbøll, Anette Susanne; Fuglsang, Leif D

    The influence of wall flexibility on earth pressure, bending moments and failure modes is studied. Numerical models are compared to results from model tests carried out in a geotechnical centrifuge. The back-fill is dry sand and failure is introduced by allowing the wall to rotate around the anchor......-model showed the right behaviour in pre-failure as well as failure for both flexible and stiff walls, whereas the MC-model showed some shortcomings when stiff walls were modelled....

  9. Analysis of anchor bolt belongs to fan in nuclear power plant

    International Nuclear Information System (INIS)

    Miao Xueliang; Luan Xingfeng; Zhang Wei; Bian Chunhua; Yu Xiaoyan; Xu Ke; Liu Hongqun

    2014-01-01

    Through on the fan anchor bolt material components, metallurgical structure and fracture analysis indicates that: material composition and microscopic are abnormal, it led to material brittle increased, the fracture is rock-candy structure, the last part is toughness structure. The reason is the the fan vibrate oversize. At last, we put forward some measures. Just like, control the vibration of the fan, set a nominal tightening torque when installing bolt. (authors)

  10. Percutaneous transcholecystic biliary interventions using gallbladder anchors: feasibility study in the swine.

    Science.gov (United States)

    Lopera, Jorge E; Kirsch, David; Qian, Zhong; Ruiz, Bernardo; Brazzini, Augusto; Gonzales, Arturo; Castaneda-Zuniga, Wilfrido

    2005-01-01

    The purpose of this study was to report our initial experience with a swine model for biliary interventions by using a percutaneous transcholecystic access after suture anchor of the gallbladder. Telepaque tablets were given to five pigs to opacify the gallbladder. Under fluoroscopy, the opacified gallbladder was punctured percutaneously and three suture anchors were used to fix the anterior wall of the gallbladder to the abdominal wall. Two weeks later, the gallbladder was punctured and access into the distal common bile was obtained through the cystic duct. Balloon expandable stents were deployed into the distal common bile duct. Follow-up cholangiograms were obtained at 1 and 2 weeks. Necropsy was performed after 2 weeks to evaluate the relationship between the gallbladder and abdominal wall. Suture anchor placement was successful in all five pigs. One pig with a deep and highly positioned gallbladder developed fever, anorexia, and vomiting secondary to excessive stretch of the gallbladder. Placement of the guidewire through the extremely tortuous and small cystic ducts proved to be the most challenging step of the procedure. Metallic stents were successfully deployed in all four pigs in which it was attempted. Four animals tolerated the procedures without changes in their clinical conditions and no symptoms. Successful follow-up cholangiograms were performed at 1 and 2 weeks post-stent deployment without complications. All stents remained patent during the follow-up period. Necropsy demonstrated close attachment and adherence of the gallbladders to the antero-lateral abdominal wall in all four animals. Suture anchoring of the gallbladder is feasible in most pigs with superficially located gallbladders. This technique allows a safe and repeat access into the biliary system using a transcholecystic approach.

  11. Anchoring Growth: The Importance of Productivity-Enhancing Reforms in Emerging Market and Developing Economies

    OpenAIRE

    Era Dabla-Norris; Giang Ho; Kalpana Kochhar; Annette Kyobe; Robert Tchaidze

    2014-01-01

    Fostering and sustaining robust economic growth is an imperative across advanced, emerging, and low-income countries alike. Countries will need to focus on supply-side reforms to raise their potential output and anchor medium-term growth prospects. This SDN will emphasize the role of structural reforms and supportive policy and institutional frameworks for boosting productivity–a key engine of economic growth–in the wake of the crisis. By examining a broad spectrum of reforms that eliminate i...

  12. Preference for different anchor descriptors on visual analogue scales among Japanese patients with chronic pain.

    Directory of Open Access Journals (Sweden)

    Junya Yokobe

    Full Text Available CONTEXT: Although many previous studies have examined the preference of patients for different pain measurement scales, preference for anchor descriptors has not been thoroughly discussed. OBJECTIVES: To examine (1 the preferred end-phrases used in the VAS as anchor labels for Japanese patients with chronic pain, and (2 whether the preference differs according to factors such as age, sex, educational level, duration of pain, and pain intensity. METHODS: We performed an observational study in patients suffering from non-cancer chronic pain for more than 3 months at a pain center in Japan. The patients were asked to rate their pain intensity using four types of VAS that used the following different anchor descriptors: "worst pain" ("Worst", "worst pain bearable" ("Bearable", "worst pain imaginable" ("Imaginable", and "worst pain you have ever experienced" ("Experienced". They were also asked to rank the four scales according to ease of responding, and asked which descriptor best reflected their perceived pain. RESULTS: In total, 183 patients participated in the study. They consisted of 119 (65.0% women and 64 (35.0% men aged 18-84 years with the mean age of 56.9 years. "Experienced" was most preferred (69.8%, followed by "Bearable" (66.3%, "Worst" (48.8%, and "Imaginable" (16.9%. Factors such as age, sex, educational background, duration of pain, and pain intensity did not significantly affect the results. In 83.1% of patients, the preferred descriptor corresponded to the descriptor that best reflected patients' perceived pain. CONCLUSION: The frequently used expression "worst pain imaginable" is considered to be difficult to understand for most patients. Widely preferred descriptors, such as "worst pain you have ever experienced" and "worst pain bearable", should be used when evaluating perceived pain. The preference of anchor descriptors was not significantly affected by the factors such as age, sex, educational level, duration of pain, and pain

  13. Percutaneous Transcholecystic Biliary Interventions Using Gallbladder Anchors: Feasibility Study in the Swine

    International Nuclear Information System (INIS)

    Lopera, Jorge E.; Kirsch, David; Qian Zhong; Ruiz, Bernardo; Brazzini, Augusto; Gonzales, Arturo; Castaneda-Zuniga, Wilfrido

    2005-01-01

    The purpose of this study was to report our initial experience with a swine model for biliary interventions by using a percutaneous transcholecystic access after suture anchor of the gallbladder. Telepaque tablets were given to five pigs to opacify the gallbladder. Under fluoroscopy, the opacified gallbladder was punctured percutaneously and three suture anchors were used to fix the anterior wall of the gallbladder to the abdominal wall. Two weeks later, the gallbladder was punctured and access into the distal common bile was obtained through the cystic duct. Balloon expandable stents were deployed into the distal common bile duct. Follow-up cholangiograms were obtained at 1 and 2 weeks. Necropsy was performed after 2 weeks to evaluate the relationship between the gallbladder and abdominal wall. Suture anchor placement was successful in all five pigs. One pig with a deep and highly positioned gallbladder developed fever, anorexia, and vomiting secondary to excessive stretch of the gallbladder. Placement of the guidewire through the extremely tortuous and small cystic ducts proved to be the most challenging step of the procedure. Metallic stents were successfully deployed in all four pigs in which it was attempted. Four animals tolerated the procedures without changes in their clinical conditions and no symptoms. Successful follow-up cholangiograms were performed at 1 and 2 weeks post-stent deployment without complications. All stents remained patent during the follow-up period. Necropsy demonstrated close attachment and adherence of the gallbladders to the antero-lateral abdominal wall in all four animals. Suture anchoring of the gallbladder is feasible in most pigs with superficially located gallbladders. This technique allows a safe and repeat access into the biliary system using a transcholecystic approach

  14. Business Model Innovation - Studies on business model design, protection, and anchoring

    OpenAIRE

    Bonakdar Amir

    2015-01-01

    This dissertation explores how firms create and capture value with business model innovation. The goal is to contribute to research on business model innovation and to thereby strengthen firms’ capabilities to innovate their business models more strategically and in a more sophisticated way as most of them already do for their products and technologies. The dissertation consists of four individual articles that address questions on business model design protection and the anchoring of busines...

  15. Corroded Anchor Structure Stability/Reliability (CAS_Stab-R) Software for Hydraulic Structures

    Science.gov (United States)

    2017-12-01

    Steel —Corrosion, Structural stability 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT SAR 18. NUMBER OF PAGES 196 19a. NAME OF...area of steel cables until the cable capacity is less than the tension force applied when the anchor cable was initially installed. When enough...utilized at the time of installation. The capacity of a cable decreases as steel material is lost from the strands of the cable due to corrosive

  16. Synthesis and structural characterization of a mimetic membrane-anchored prion protein

    OpenAIRE

    Hicks, M R; Gill, A C; Bath, I K; Rullay, A K; Sylvester, I D; Crout, D H; Pinheiro, T J T

    2006-01-01

    During pathogenesis of transmissible spongiform encephalopathies (TSEs) an abnormal form (PrPSc) of the host encoded prion protein (PrPC) accumulates in insoluble fibrils and plaques. The two forms of PrP appear to have identical covalent structures, but differ in secondary and tertiary structure. Both PrPC and PrPSc have glycosylphospatidylinositol (GPI) anchors through which the protein is tethered to cell membranes. Membrane attachment has been suggested to play a role in the conversion of...

  17. Effects of flexoelectricity and weak anchoring on a Freedericksz transition cell

    Science.gov (United States)

    Mema, E.; Kondic, L.; Cummings, L. J.

    2017-01-01

    We consider a mathematical model that consists of a nematic liquid crystal layer sandwiched between two parallel bounding plates, across which an external field is applied. We investigate how the number and type of solutions for the director orientation within the layer change as the field strength, anchoring conditions, and material properties of the nematic liquid crystal layer vary. In particular, we focus on how the inclusion of flexoelectric effects alters the Freedericksz and saturation thresholds.

  18. Decay accelerating factor of complement is anchored to cells by a C-terminal glycolipid

    International Nuclear Information System (INIS)

    Medof, M.E.; Walter, E.I.; Roberts, W.L.; Haas, R.; Rosenberry, T.L.

    1986-01-01

    Membrane-associated decay accelerating factor (DAF) of human erythrocytes (E/sup hu/) was analyzed for a C-terminal glycolipid anchoring structure. Automated amino acid analysis of DAF following reductive radiomethylation revealed ethanolamine and glucosamine residues in proportions identical with those present in the E/sup hu/ acetylcholinesterase (AChE) anchor. Cleavage of radiomethylated 70-kilodalton (kDa) DAF with papain released the labeled ethanolamine and glucosamine and generated 61- and 55-kDa DAF products that retained all labeled Lys and labeled N-terminal Asp. Incubation of intact E/sup hu/ with phosphatidylinositol-specific phospholipase C (PI-PLC), which cleaves the anchors in trypanosome membrane form variant surface glycoproteins (mfVSGs) and murine thymocyte Thy-1 antigen, released 15% of the cell-associated DAF antigen. The released 67-kDa PI-PLC DAF derivative retained its ability to decay the classical C3 convertase C4b2a but was unable to membrane-incorporate and displayed physicochemical properties similar to urine DAF, a hydrophilic DAF form that can be isolated for urine. Nitrous acid deamination cleavage of E/sup hu/ DAF at glucosamine following labeling with the lipophilic photoreagent 3-(trifluoromethyl)-3-(m-[ 125 I]iodophenyl)diazirine ([ 125 I]TID) released the [ 125 I]TID label in a parallel fashion as from [ 125 I]TID-labeled AChE. Biosynthetic labeling of HeLa cells with [ 3 H] ethanolamine resulted in rapid 3 H incorporation into both 48-kDa pro-DAF and 72-kDa mature epithelial cell DAF. The findings indicate that DAF and AChE are anchored in E/sup hu/ by the same or a similar glycolipid structure and that, like VSGs, this structure is incorporated into DAF early in DAF biosynthesis prior to processing of pro-DAF in the Golgi

  19. A Comparative Study of McDonald’s Wedding Narratives with the Model of Anchoring

    Directory of Open Access Journals (Sweden)

    Mimi Huang

    2016-12-01

    Full Text Available Fast-food giant McDonald’s announced in 2010 that they would start hosting wedding ceremonies and receptions for couples who would like to get married in their restaurants in Hong Kong. This paper conducts a study comparing the differing representations of McDonald’s wedding services through a narrative analytical approach. Specifically, this paper examines relevant discourses surrounding the launch of the corporation’s wedding services from the British media (e.g. Daily Mail, the Independent as well as public discourses in Hong Kong (e.g. McDonald’s Hong Kong website, and CNN’s Hong Kong news.  It is found that these narratives have a significant degree of discrepancy in depicting McDonald’s wedding stories. These differences further raise the question of how differing narrative strategies are employed to conceptualise the brand’s emergent wedding narratives in a unique social-cultural environment.  In the discussion of McDonald’s wedding stories, the focus is placed on the cognitive and linguistic aspects of the discourse. An analytical model of “anchoring” will be proposed and applied to investigate the cooperation’s marketing strategies as well as the media’s reaction towards such promotions. It is argued that a narrative can promote or demote a brand’s identity and position through the process of anchoring. It is further argued that anchoring is an important cognitive-psychological strategy in conceptualization and meaning construction. Keywords: narrative inquiry, cognitive narratology, anchors, anchoring, meaning construction

  20. The mitochondrial genomes of Atlas Geckos (Quedenfeldtia): mitogenome assembly from transcriptomes and anchored hybrid enrichment datasets

    OpenAIRE

    Lyra, Mariana L.; Joger, Ulrich; Schulte, Ulrich; Slimani, Tahar; El Mouden, El Hassan; Bouazza, Abdellah; Künzel, Sven; Lemmon, Alan R.; Moriarty Lemmon, Emily; Vences, Miguel

    2017-01-01

    The nearly complete mitogenomes of the two species of North African Atlas geckos, Quedenfeldtia moerens and Q. trachyblepharus were assembled from anchored hybrid enrichment data and RNAseq data. Congruent assemblies were obtained for four samples included in both datasets. We recovered the 13 protein-coding genes, 22 tRNA genes, and two rRNA genes for both species, including partial control region. The order of genes agrees with that of other geckos.

  1. The relation between career anchors, occupational types and job satisfaction of midcareer employees

    Directory of Open Access Journals (Sweden)

    J. A. Ellison

    2000-06-01

    Full Text Available The objective of this research was to determine the value of the career anchor model in career decision-making. Career models that can provide the individual with greater self-insight can serve as an important guide when making career choices in todays turbulent working environment. Two hundred and ninety-five midcareer employees (managerial and non-managerial completed questionnaires to determine their career anchor, occupation type and levels of general, intrinsic and extrinsic job satisfaction. The differences in job satisfaction between employees with a fit between career anchor and occupational type and those with no such fit were compared. It was found that respondents with a fit had a significantly higher level of general and intrinsic job satisfaction than those with no such fit. It is therefore suggested that the career anchor construct could probably serve as a useful tool for midcareer employees to make career choices. Opsomming Die doel van hierdie ondersoek was om die waarde van die loopbaanankermodel in loopbaanbesluitneming te bepaal. Loopbaanmodelle wat individue van groter insig kan voorsien kan as n belangrike riglyn in vandag se turbulente werksomgewing dien. Tweehonderd vyf-en-negentig middelloopbaan-werknemers (bestuur en nie-bestuur het vraelyste voltooi om hulle loopbaanankers, beroepstipe en vlakke van algemene, intrinsieke en ekstrinsieke werkstevredenheid te bepaal. Die verskille in werkstevredenheid tussen werknemers met n passing tussen loopbaananker en beroepstipe en die sender n sodanige passing, is vergelyk. Daar is bevind dat respondente met n passing 'n beduidende hoer vlak van algemene en intrinsieke werkstevredenheid het as die sender so 'n passing. Daar word derhalwe voorgestel dat die loopbaanankermodel waarskynlik as n nuttige instrument by middelloopbaan-werknemers gebruik kan word om loopbaanbesluite te neem.

  2. A Double Rate Localization Algorithm with One Anchor for Multi-Hop Underwater Acoustic Networks

    Science.gov (United States)

    Gao, Jingjie; Shen, Xiaohong; Zhao, Ruiqin; Mei, Haodi; Wang, Haiyan

    2017-01-01

    Localization is a basic issue for underwater acoustic networks (UANs). Currently, most localization algorithms only perform well in one-hop networks or need more anchors which are not suitable for the underwater environment. In this paper, we proposed a double rate localization algorithm with one anchor for multi-hop underwater acoustic networks (DRL). The algorithm firstly presents a double rate scheme which separates the localization procedure into two modes to increase the ranging accuracy in multi-hop UANs while maintaining the transmission rate. Then an optimal selection scheme of reference nodes was proposed to reduce the influence of references’ topology on localization performance. The proposed DRL algorithm can be used in the multi-hop UANs to increase the localization accuracy and reduce the usage of anchor nodes. The simulation and experimental results demonstrated that the proposed DRL algorithm has a better localization performance than the previous algorithms in many aspects such as accuracy and communication cost, and is more suitable to the underwater environment. PMID:28452942

  3. Strand Tension Control in Anchor Span for Suspension Bridge Using Dynamic Balance Theory

    Directory of Open Access Journals (Sweden)

    Da Wang

    Full Text Available Abstract Strand tension control is essential in suspension bridge safety. However, few quantitative studies have examined the bending rigidity and boundary condition behavior of strands in the anchor span of suspension bridges because of their special structure and complex configuration. In this paper, a new calculation method for strand tension is explored by using dynamic balance theory to determine the effect of bending rigidity and boundary conditions. The accuracy and effectiveness of the proposed method are tested and confirmed with verification examples and application on Nanxi Yangtze Suspension Bridge in China. The results indicated that only low-order frequency calculation could be used to calculate the strand tension without considering the effect of bending rigidity to ensure control accuracy. The influence of bending rigidity on the control precision is related to the tension and the length of the strands, which is significantly determined by the specific value between the stress rigidity and the bending rigidity. The uncertain boundary conditions of the anchor span cable, which are fixed between consolidated and hinged, also have a major effect on the control accuracy. To improve the accuracy of strand tension control, the least squares method is proposed during the tension construction control of the anchor span. This approach can significantly improve the accuracy of the tension control of the main cable strand. Some recommendations for future bridge analysis are provided based on the results of this study.

  4. Evaluation of postoperative results from videoarthroscopic treatment for recurrent shoulder dislocation using metal anchors

    Directory of Open Access Journals (Sweden)

    Éder Menegassi Martel

    2016-02-01

    Full Text Available ABSTRACT OBJECTIVE: To clinically and radiologically evaluate the results from videoarthroscopic treatment using metal anchors in patients with recurrent shoulder dislocation and its complications. METHODS: This was a retrospective study on 47 patients (47 shoulders operated by the shoulder group of the orthopedic hospital between February 2010 and February 2012. A questionnaire, interview and physical and radiographic examinations were used, with the classification of Samilson and Pietro. The mean postoperative follow-up was 33 months (range 12-47 months. The statistical analysis consisted of using Fisher's exact test through the IBM SPSS 22 statistical software. The significance level used was 5%. RESULTS: Recurrence was observed in nine cases. The patients were, on average, 26.5 years old at the first episode, and 19.1% were aged 20 years or under. Among these, 55.6% presented recurrence. In relation to age at the time of the surgical procedure, the average age was 27 years, and 12.8% were aged 20 years or under. Nineteen patients presented prominent anchors and, of these, 21% manifested arthrosis. CONCLUSION: There was a statistically identified correlation between the recurrence rate and age less than or equal to 20 years at the times of first dislocation and the surgical procedure. Further studies should be conducted in order to compare the use of absorbable anchors, which despite higher cost, may provide lower risk of developing glenohumeral arthrosis in some cases.

  5. Anchor Dragging Analysis of Rock-Berm Using Smoothed Particle Hydrodynamics Method

    Directory of Open Access Journals (Sweden)

    Jinho Woo

    2015-01-01

    Full Text Available This study presents dynamic responses of rock-berm structural system under anchor dragging and accordingly provides the characteristics of the stresses and displacements obtained. For the purpose, first, a rock-berm was modeled by the SPH (smoothed particle hydrodynamics method and piecewise Drucker-Prager material model by facilitating the associated software package—ANSYS-AUTODYN. Second, 2-ton stockless anchor was modeled as a rigid body and eventually dragging external force was obtained. Then, the dragging velocity (1 and 2 m/s was considered as a parameter to investigate the effect of its variation on the responses. Finally, the dragging tensile forces of the anchor cable were obtained and compared according to the dragging velocities. It is shown that the four-layer rock-berm gives the safety margin to the submarine power cable according to the unaffected gauge points near the cable. This safety is accomplished by the four layers (related to rock-berm height and the number of rock particles at each layer (related to rock-berm widths.

  6. Fixation of acute distal biceps tendon ruptures using mitek anchors: a retrospective study.

    Science.gov (United States)

    Al-Taher, M; Wouters, Diederick B

    2014-01-01

    The aim of this study was to evaluate the outcomes of surgical intra-osseous fixation of the distal tendon of the ruptured biceps brachii muscle using Mitek anchors. Between 2005 and 2011, seven patients underwent unilateral distal biceps tendon repair using Mitek anchors. All patients were men aged between 36 and 47 years. Six patients were assessed by physical examination and use of the Disabilities of the Arm, Shoulder, and Hand (DASH) questionnaire. Surgery was performed within 3 to 17 days of rupture with a mean follow-up of 35 months. Of the six fully completed DASH questionnaires, three patients had a score of 0, and three patients had scores of 5.8, 10 and 10.8, respectively (10.1 is the mean score for the general population). Transient paraesthesias in the lateral antebrachial cutaneous nerve region occurred in two patients and one patient experienced a transient stiffness of the elbow due to scarring of the wound. No major complicatons have occurred. The use of Mitek anchors for the re-insertion of the ruptured distal biceps tendon proved to be a safe and effective technique with excellent functional results in our series.

  7. Novel Bone-Anchored Vascular Access on the Mastoid for Hemodialysis: Concept and Preclinical Trials.

    Science.gov (United States)

    Stieger, Christof; Arnold, Andreas; Kruse, Anja; Wiedmer, Simona; Widmer, Matthias; Guignard, Jeremie; Schutz, Daniel; Guenat, Jean-Marc; Bachtler, Matthias; Caversaccio, Marco; Uehlinger, Dominik E; Frey, Felix J; Hausler, Rudolf

    2016-05-01

    We present the development of a bone-anchored port for the painless long-term hemodialytic treatment of patients with renal failure. This port is implanted behind the ear. The port was developed based on knowledge obtained from long-term experience with implantable hearing devices, which are firmly anchored to the bone behind the ear. This concept of bone anchoring was adapted to the requirements for a vascular access during hemodialysis. The investigational device is comprised of a base plate that is firmly fixed with bone screws to the bone behind the ear (temporal bone). A catheter leads from the base plate valve block through the internal jugular vein and into the right atrium. The valves are opened using a special disposable adapter, without any need to puncture the blood vessels. Between hemodialysis sessions, the port is protected with a disposable cover. Flow rate, leak tightness, and purification were tested on mockups. Preoperative planning and the surgical procedure were verified in 15 anatomical human whole head specimens. Preclinical evaluations demonstrated the technical feasibility and safety of the investigational device. Approximately 1.5 million people are treated with hemodialysis worldwide, and 25% of the overall cost of dialysis therapy results from vascular access problems. New approaches toward enhancing vascular access could potentially reduce the costs and complications of hemodialytic therapy.

  8. Quantitative retrotransposon anchored PCR confirms transduction efficiency of transgenes in adult Schistosoma mansoni.

    Science.gov (United States)

    Rinaldi, Gabriel; Suttiprapa, Sutas; Brindley, Paul J

    2011-05-01

    A quantitative retrotransposon anchored PCR (qRAP) that utilizes endogenous retrotransposons as a chromosomal anchor was developed to investigate integration of transgenes in Schistosoma mansoni. The qRAP technique, which builds on earlier techniques, (i) Alu-PCR which has been used to quantify lentiviral (HIV-1) proviral insertions in human chromosomes and (ii) a non-quantitative retrotransposon anchored PCR known to detect the presence of transgenes in the S. mansoni genome, was tested here in a model comparison of retrovirus-transduced adult schistosomes in which one group included intact worms, the other included fragments of adult worms. At the outset, after transducing intact and viable fragments of schistosomes with reporter RNAs, we observed more reporter activity in fragments of worms than in intact worms. We considered this simply reflects the increased surface area in fragments compared to intact worms exposed to the exogenous reporter genes. Subsequently, intact worms and worm fragments were transduced with pseudotyped virions. Transgene integration events in genomic DNA extracted from the virion-exposed worms and worm fragments were quantified by the qRAP, which revealed that fragmenting adult schistosomes resulted in increased density of proviral integrations. The qRAP findings confirmed the likely value of this qRAP technique for quantification of transgenes integrated in schistosome chromosomes. Last, considering the absence of schistosome cell or tissue lines, primary culture of fragmented worms offers an opportunity to optimize transgenesis, and other functional genomic approaches. Copyright © 2011 Elsevier B.V. All rights reserved.

  9. Anchored reference loci in loblolly pine (Pinus taeda L.) for integrating pine genomics.

    Science.gov (United States)

    Brown, G R; Kadel, E E; Bassoni, D L; Kiehne, K L; Temesgen, B; van Buijtenen, J P; Sewell, M M; Marshall, K A; Neale, D B

    2001-01-01

    Anchored reference loci provide a framework for comparative mapping. They are landmarks to denote conserved chromosomal segments, allowing the synthesis of genetic maps from multiple sources. We evaluated 90 expressed sequence tag polymorphisms (ESTPs) from loblolly pine (Pinus taeda L.) for this function. Primer sets were assayed for amplification and polymorphism in six pedigrees, representing two subgenera of Pinus and a distant member of the Pinaceae, Douglas-fir (Pseudotsuga menziesii [Mirb.] Franco). On average, 89% of primer sets amplified in four species of subgenus Pinus, 49% in one species of subgenus Strobus, and 22% in Douglas-fir. Polymorphisms were detected for 37-61% of the ESTPs within each pedigree. Comparative mapping in loblolly and slash pine (P. elliottii Englm.) revealed that ESTPs mapped to the same location. Disrupted synteny or significant disruptions in colinearity were not detected. Thirty-five ESTPs met criteria established for anchor loci. The majority of those that did not meet these criteria were excluded when map location was known in only a single species. Anchor loci provide a unifying tool for the community, facilitating the creation of a "generic" pine map and serving as a foundation for studies on genome organization and evolution. PMID:11606554

  10. Design Analysis and Observed Performance of a Tieback Anchored Pile Wall in Sand

    Directory of Open Access Journals (Sweden)

    Jian-Yong Han

    2017-01-01

    Full Text Available This paper aims to study the design process and service performance of a deep excavation supported by tieback anchored pile walls. The design procedure and design approaches for deep excavation in China are described. Based on the excavation case history for Shenyang, China, design results obtained using the elastic method and the finite element method (FEM are compared and analyzed. Special emphasis is given to the analysis of horizontal wall deformations, internal forces in the wall, earth pressures on the wall, ground surface settlements, and stabilities of the excavation. The similarities and differences between the Chinese code (JGJ 120-2012 and the European code (EN 1997-1 for the design of geotechnical structures are presented based on a design example. Through the comparison, it is indicated that the Chinese code focuses on the design result, while the European code focuses on the design process. The crucial construction methods for reducing construction risk based on the excavation case history are described. The mechanical behaviors of the excavation retained by an anchored pile wall were investigated by analyzing observed field cases. The results provide good, practical guidelines for the design and construction of a tieback anchored pile wall retained excavation in sandy soil.

  11. Blue-light-induced rapid chloroplast de-anchoring in Vallisneria epidermal cells.

    Science.gov (United States)

    Sakai, Yuuki; Inoue, Shin-ichiro; Harada, Akiko; Shimazaki, Ken-Ichiro; Takagi, Shingo

    2015-01-01

    In the outer periclinal cytoplasm of leaf epidermal cells of an aquatic angiosperm Vallisneria, blue light induces "chloroplast de-anchoring", a rapid decline in the resistance of chloroplasts against centrifugal force. Chloroplast de-anchoring is known induced within 1 min of irradiation with high-fluence-rate blue light specifically, preceding the commencement of chloroplasts migration toward the anticlinal cytoplasm. However, its regulatory mechanism has remained elusive, although pharmacological analysis suggested that a calcium release from intracellular calcium stores is necessary for the response. In search of the responsible photoreceptors, immunoblotting analysis using antibodies against phototropins demonstrated that cross-reactive polypeptides of 120-kDa exist in the plasma-membrane fraction prepared from the leaves. In vitro phosphorylation analysis revealed that 120-kDa polypeptides were phosphorylated by exposure to blue light in a fluence-dependent manner. The blue-light-induced phosphorylation activity was sensitive to a Ser/Thr kinase inhibitor, staurosporine, and unusually was retained at a high level for a long time in darkness. Furthermore, phototropin gene homologs (Vallisneria PHOTOTROPIN1 and PHOTOTROPIN2) expressed in leaves were isolated. We propose that calcium-regulated chloroplast de-anchoring, possibly mediated by phototropins, is an initial process of the blue-light-induced avoidance response of chloroplasts in Vallisneria. © 2014 Institute of Botany, Chinese Academy of Sciences.

  12. One platform comparison of estrone and folic acid anchored surface engineered MWCNTs for doxorubicin delivery.

    Science.gov (United States)

    Mehra, Neelesh Kumar; Jain, N K

    2015-02-02

    Our main aim in the present investigation was to assess and compare the in vitro and in vivo cancer targeting propensity of doxorubicin (DOX) loaded folic acid (FA) and estrone (ES) anchored PEGylated multiwalled carbon nanotubes (MWCNTs) employing tumor bearing Balb/c mice. The DOX was loaded into the developed functionalized MWCNTs after proper characterization using dialysis diffusion method. The in vitro, ex vivo, and in vivo studies were performed on the MCF-7 cell line for assessment of the cancer targeting propensity. Both qualitative and quantitative cell uptake studies indicated the preferential higher uptake of estrone anchored nanotube formulation compared to other formulations and free DOX owing to the overexpression of estrogen receptors (ERs) on human breast MCF-7 cells. Similarly, the pharmacokinetic and increased antitumor activities also confirmed the elevated cancer targeting propensity of the estrone and folic acid anchored MWCNT formulations. The DOX/ES-PEG-MWCNTs has also shown significantly longer survival span (43 days) than free DOX (18 days) and control group (12 days). Present outcomes from the ex vivo and in vivo studies are deemed to be of great scientific value and shall assist targeted drug delivery formulation scientists for selection of the targeting moieties in the treatment of human breast cancer.

  13. Investigating the relationship between employees’ career anchors and their psychosocial employability attributes in a financial company

    Directory of Open Access Journals (Sweden)

    Rudolf M. Oosthuizen

    2014-10-01

    Research purpose: The objective of the study was to investigate the relationship between employees’ career anchors and their psychosocial employability attributes as important career meta-capacities in contemporary career development. The study also investigated whether individuals from different age and race groups differed significantly regarding these career meta-capacities. Motivation for the study: Career management has become essential in the contemporary workplace for employees to sustain their employability. Research points to the importance of psychosocial career meta-capacities in helping employees to manage their career development and employability. Research design, approach and method: A cross-sectional quantitative survey using primary data was conducted on a non-probability purposive sample (N = 108 of full-time employees (67% women; 78% 26–45 years old; 78% black employees at a South African financial company. Correlations and Scheffé’s post-hoc test were performed to achieve the research objectives. Main findings: Significant positive relationships were observed between the participants’ career anchors and their psychosocial employability attributes. Age and race groups differed significantly only in terms of their career anchors. Practical/managerial implications: Career management practices in the organisation should accommodate the differences in career orientations and how these relate to the psychosocial employability attributes of their employees. Contribution: The findings add potentially important insights that may inform human resource practices aimed at enhancing the career development and employability of employees and addressing the career needs of different age and race groups.

  14. Nematic ordering in a cell with modulated surface anchoring: effects of flexoelectricity.

    Science.gov (United States)

    Barbero, G; Skacej, G; Alexe-Ionescu, A L; Zumer, S

    1999-07-01

    We have analyzed molecular ordering in a nematic sample sandwiched between two parallel substrates, characterized by a periodically varying anchoring easy axis. If the periodicity lambda is smaller than the Debye screening length l(D) and the nematic material possesses flexoelectric properties, it is necessary to take into account also the electrostatic and flexoelectric contributions in the thermodynamical potential when the actual director field is determined. In this framework, for small deviations from the homeotropic alignment we have derived analytical expressions for the tilt angle (theta) and the electrical potential. To establish a connection with experimentally observable quantities, we have related the theta profile to the average and investigated its behavior for different values of lambda, the flexoelectric coefficient, and the anchoring strength w. Our results indicate that in a nematic with pronounced flexoelectric properties for small enough lambda, a kind of subsurface deformation appears, which substantially decreases . Therefore, effects of flexoelectricity cannot be neglected in treating nematic cells with modulated anchoring which allows bistable ordering.

  15. Nematic ordering in a cell with modulated surface anchoring: Effects of flexoelectricity

    Science.gov (United States)

    Barbero, G.; Skačej, G.; Alexe-Ionescu, A. L.; Žumer, S.

    1999-07-01

    We have analyzed molecular ordering in a nematic sample sandwiched between two parallel substrates, characterized by a periodically varying anchoring easy axis. If the periodicity λ is smaller than the Debye screening length lD and the nematic material possesses flexoelectric properties, it is necessary to take into account also the electrostatic and flexoelectric contributions in the thermodynamical potential when the actual director field is determined. In this framework, for small deviations from the homeotropic alignment we have derived analytical expressions for the tilt angle (θ) and the electrical potential. To establish a connection with experimentally observable quantities, we have related the θ profile to the average and investigated its behavior for different values of λ, the flexoelectric coefficient, and the anchoring strength w. Our results indicate that in a nematic with pronounced flexoelectric properties for small enough λ, a kind of subsurface deformation appears, which substantially decreases . Therefore, effects of flexoelectricity cannot be neglected in treating nematic cells with modulated anchoring which allows bistable ordering.

  16. Combination probes with intercalating anchors and proximal fluorophores for DNA and RNA detection.

    Science.gov (United States)

    Qiu, Jieqiong; Wilson, Adam; El-Sagheer, Afaf H; Brown, Tom

    2016-09-30

    A new class of modified oligonucleotides (combination probes) has been designed and synthesised for use in genetic analysis and RNA detection. Their chemical structure combines an intercalating anchor with a reporter fluorophore on the same thymine nucleobase. The intercalator (thiazole orange or benzothiazole orange) provides an anchor, which upon hybridisation of the probe to its target becomes fluorescent and simultaneously stabilizes the duplex. The anchor is able to communicate via FRET to a proximal reporter dye (e.g. ROX, HEX, ATTO647N, FAM) whose fluorescence signal can be monitored on a range of analytical devices. Direct excitation of the reporter dye provides an alternative signalling mechanism. In both signalling modes, fluorescence in the unhybridised probe is switched off by collisional quenching between adjacent intercalator and reporter dyes. Single nucleotide polymorphisms in DNA and RNA targets are identified by differences in the duplex melting temperature, and the use of short hybridization probes, made possible by the stabilisation provided by the intercalator, enhances mismatch discrimination. Unlike other fluorogenic probe systems, placing the fluorophore and quencher on the same nucleobase facilitates the design of short probes containing multiple modifications. The ability to detect both DNA and RNA sequences suggests applications in cellular imaging and diagnostics. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

  17. Bone-anchored hearing aids in conductive and mixed hearing losses: why do patients reject them?

    Science.gov (United States)

    Siau, Richard T K; Dhillon, Baljeet; Siau, Derrick; Green, Kevin M J

    2016-10-01

    This study aimed to report the bone-anchored hearing aid uptake rate and the reasons for their rejection by patients with conductive and mixed hearing losses. A retrospective review was performed of 113 consecutive patients with unilateral or bilateral conductive or mixed hearing loss referred to the Greater Manchester bone-anchored hearing aid (BAHA) programme between September 2008 and August 2011. 98 (86.7 %) patients were deemed audiologically suitable for BAHA implantation. Of these, 38 (38.8 %) had BAHA implanted; 60 (61.2 %) patients declined. Of those who declined, 27 (45 %) cited anxiety over surgery, 18 (30 %) cited cosmetic reasons, 16 (26.7 %) perceived limited benefit from the device and six (10 %) preferred conventional hearing aids. Our study highlights a 38.8 % BAHA uptake rate in audiologically suitable patients. The main reasons cited for rejection of BAHA were anxiety over surgery and cosmetic concerns. It is important that clinicians address these early during consultation with prospective BAHA recipients and avoid rushing to implant these patients with a bone-anchored hearing aid.

  18. Simplified bone-anchored hearing aid insertion using a linear incision without soft tissue reduction.

    Science.gov (United States)

    Husseman, J; Szudek, J; Monksfield, P; Power, D; O'Leary, S; Briggs, R

    2013-07-01

    Numerous techniques have been described to manage the skin and other soft tissues during bone-anchored hearing aid insertion. Previously, generally accepted techniques have sometimes led to distressing alopecia and soft tissue defects. Now, some surgeons are rejecting the originally described split skin flap in favour of a less invasive approach. To investigate bone-anchored hearing aid placement utilising a single, linear incision with either no or minimal underlying soft tissue reduction. Thirty-four adults were prospectively enrolled to undergo single-stage bone-anchored hearing aid placement with this modified technique. A small, linear incision was used at the standard position and carried down through the periosteum. Standard technique was then followed with placement of an extended length abutment. Patients were reviewed regularly to assess wound healing, including evaluation with Holgers' scale. Only 14.7 per cent of patients had a reaction score of 2 or higher. Most complications were limited to minor skin reactions that settled with silver nitrate cautery and/or antibiotics. None required revision surgery for tissue overgrowth, and there were no implant failures. Our results suggest this to be a simple and effective insertion technique with favourable cosmesis and patient satisfaction.

  19. Outcome of the bone-anchored hearing aid procedure without skin thinning: a prospective clinical trial.

    Science.gov (United States)

    Hultcrantz, Malou

    2011-09-01

    To evaluate the outcome of Bone-Anchored Hearing Aid surgery without skin thinning, a test group with direct implantation without such thinning was compared with a control group that underwent the traditional procedure. This was a single-center, prospective clinical trial designed to evaluate a novel approach to Bone-Anchored Hearing Aid implantation. Eligible patients were enrolled consecutively in the test group or selected to be age-matched controls. University Hospital. Eighteen adult patients, suffering from hearing loss, suitable for implantable hearing aid. Single-step surgery was performed on 18 patients under local anesthesia. In 9 of these, a linear incision was made, a hole was punched through the skin above the bone-anchored implant, and a longer abutment (8.5-12 mm) was introduced, whereas the other 9 were subjected to the standard protocol, using a dermatome and skin thinning. All of the patients were followed for 12 months. The test group exhibited good preservation of the tissue, no increasing skin reactions and no adverse events. The time required for this surgery was reduced, as was their healing time. These patients also experienced less numbness and pain in the surrounding area and had an improved cosmetic outcome. MAIN OUTCOME AND CONCLUSION: This clinical trial indicates that introduction of the abutment to the osseointegrated screw directly through the skin, without skin thinning, could be beneficial. This approach had fewer negative effects than the conventional procedure during the 12- month follow-up period.

  20. Site for bone-anchored hearing system for children younger than 5 years.

    Science.gov (United States)

    Ukatu, Ceisha Chinwe; Desai, Nilesh Kundanlal; Todd, Norman Wendell

    2015-02-01

    To describe in children younger than the present US FDA-approved 5 years of age the thickest part of the temporal bone available for placement of a bone-anchored hearing system. Children with unilateral hearing loss, as with aural atresia, have deficits in at least language comprehension and oral expression. The early provision of hearing to the atretic ear may minimize the potential for auditory deprivation. Point prevalence descriptive study. Tertiary referral pediatric hospital. Thirty-eight patients less than 6 years old with congenital aural atresia had undergone temporal bone computed tomography (CT). Bone thickness lateral (ie, superficial) to the sinodural angle, in the topmost axial CT slice that included any adjacent petrous ridge, was measured. The mean bone thicknesses lateral to the sinodural angles of the atretic ears were 5.1, 5.0, 5.9, 5.2, 5.2, and 4.8 mm for the bone thickness lateral (ie, superficial) to the sinodural angle is sufficient for many children suffering from aural atresia to have bone-anchored hearing devices implanted younger than age 5 years. Use of the sinodural site would require a magnetic bone-anchored hearing system, which could be repositioned posteriorly at age 5 years when pinna construction and atresiaplasty endeavors typically begin. © American Academy of Otolaryngology—Head and Neck Surgery Foundation 2014.

  1. Ethnic disparity in skin complications following bone-anchored hearing aid implantation.

    Science.gov (United States)

    Zeitler, Daniel M; Herman, Bjorn S; Snapp, Hillary A; Telischi, Fred F; Angeli, Simon I

    2012-08-01

    Sound processor loading after implantation of a bone-anchored hearing aid is often delayed by skin-site complications. This study examined the frequency of skin-site complications in various ethnic groups and determined factors that may lead to higher rates of skin-site complications resulting in delayed processor loading. Adult, English-speaking patients who underwent implantation of a bone-anchored hearing aid between 2007 and 2010 were reviewed. Demographic data including ethnicity, tobacco use, diabetes mellitus, immunosuppression, and long-term steroid use were determined. Major and minor skin-site complications and the time to processor loading were recorded. The mean time to processor loading was 9.5 weeks, and the mean follow-up time was 23 months. There were no cases of osseointegration failure. African American patients had a significantly higher rate of major skin-site complications (p bone-anchored hearing aid. There is a higher rate of major skin-site complications in African American patients, and these often delay processor loading. The risk of skin-site complications is not correlated with smoking, diabetes mellitus, or immunosuppression. An increased risk of skin-site complications is an important consideration for preoperative counseling.

  2. A load measuring anchor plate for rock bolt using fiber optic sensor

    Science.gov (United States)

    Ho, Siu Chun Michael; Li, Weijie; Wang, Bo; Song, Gangbing

    2017-05-01

    Rock bolts are the devices that used to reinforce the rock masses in mining tunnels and underground excavation structures. The loading level of the rock bolt indicates the reinforcing efficiency and is able to ensure safe underground operation by giving warnings to the underground miners prior to any accidents. Therefore, it is very important to monitor the load level of the rock bolts. In this short communication, we propose a smart anchor plate, a simple but effective device that uses fiber Bragg gratings (FBG) type optic sensor, to monitor the load level of the rock bolt. Instead of measuring the stress/strain on the rock bolt, which adds more complexity, the proposed method monitors the rock bolt load by measuring the load experience on the rock bolt anchor plate. Such a configuration has the advantages of simple structure and flexible implementation. In experimental observation, the FBG instrumented anchor plate is able to observe the load of the plate with good repeatability. This test will lead to further in-depth studies involving finite element analysis as well as more complex applications.

  3. Electrical properties and mechanical stability of anchoring groups for single-molecule electronics

    Directory of Open Access Journals (Sweden)

    Riccardo Frisenda

    2015-07-01

    Full Text Available We report on an experimental investigation of transport through single molecules, trapped between two gold nano-electrodes fabricated with the mechanically controlled break junction (MCBJ technique. The four molecules studied share the same core structure, namely oligo(phenylene ethynylene (OPE3, while having different aurophilic anchoring groups: thiol (SAc, methyl sulfide (SMe, pyridyl (Py and amine (NH2. The focus of this paper is on the combined characterization of the electrical and mechanical properties determined by the anchoring groups. From conductance histograms we find that thiol anchored molecules provide the highest conductance; a single-level model fit to current–voltage characteristics suggests that SAc groups exhibit a higher electronic coupling to the electrodes, together with better level alignment than the other three groups. An analysis of the mechanical stability, recording the lifetime in a self-breaking method, shows that Py and SAc yield the most stable junctions while SMe form short-lived junctions. Density functional theory combined with non-equlibrium Green’s function calculations help in elucidating the experimental findings.

  4. Lipid Binding of the Amphipathic Helix Serving as Membrane Anchor of Pestivirus Glycoprotein Erns.

    Science.gov (United States)

    Aberle, Daniel; Oetter, Kay-Marcus; Meyers, Gregor

    2015-01-01

    Pestiviruses express a peculiar protein named Erns representing envelope glycoprotein and RNase, which is important for control of the innate immune response and persistent infection. The latter functions are connected with secretion of a certain amount of Erns from the infected cell. Retention/secretion of Erns is most likely controlled by its unusual membrane anchor, a long amphipathic helix attached in plane to the membrane. Here we present results of experiments conducted with a lipid vesicle sedimentation assay able to separate lipid-bound from unbound protein dissolved in the water phase. Using this technique we show that a protein composed of tag sequences and the carboxyterminal 65 residues of Erns binds specifically to membrane vesicles with a clear preference for compositions containing negatively charged lipids. Mutations disturbing the helical folding and/or amphipathic character of the anchor as well as diverse truncations and exchange of amino acids important for intracellular retention of Erns had no or only small effects on the proteins membrane binding. This result contrasts the dramatically increased secretion rates observed for Erns proteins with equivalent mutations within cells. Accordingly, the ratio of secreted versus cell retained Erns is not determined by the lipid affinity of the membrane anchor.

  5. Lipid Binding of the Amphipathic Helix Serving as Membrane Anchor of Pestivirus Glycoprotein Erns.

    Directory of Open Access Journals (Sweden)

    Daniel Aberle

    Full Text Available Pestiviruses express a peculiar protein named Erns representing envelope glycoprotein and RNase, which is important for control of the innate immune response and persistent infection. The latter functions are connected with secretion of a certain amount of Erns from the infected cell. Retention/secretion of Erns is most likely controlled by its unusual membrane anchor, a long amphipathic helix attached in plane to the membrane. Here we present results of experiments conducted with a lipid vesicle sedimentation assay able to separate lipid-bound from unbound protein dissolved in the water phase. Using this technique we show that a protein composed of tag sequences and the carboxyterminal 65 residues of Erns binds specifically to membrane vesicles with a clear preference for compositions containing negatively charged lipids. Mutations disturbing the helical folding and/or amphipathic character of the anchor as well as diverse truncations and exchange of amino acids important for intracellular retention of Erns had no or only small effects on the proteins membrane binding. This result contrasts the dramatically increased secretion rates observed for Erns proteins with equivalent mutations within cells. Accordingly, the ratio of secreted versus cell retained Erns is not determined by the lipid affinity of the membrane anchor.

  6. Surgical repair of central slip avulsion injuries with Mitek bone anchor--retrospective analysis of a case series.

    LENUS (Irish Health Repository)

    Chan, Jeffrey C Y

    2007-01-01

    The purpose of this study is to describe our technique of central slip repair using the Mitek bone anchor and to evaluate the treatment outcome. Eight digits in eight patients were reconstructed using the bone anchor: three little fingers, two middle fingers, two index fingers and one ring finger. There were two immediate and six delayed repairs (range from one day to eight months). Four patients had pre-operative intensive splinting and physiotherapy to restore passive extension of the proximal interphalangeal joint prior to central slip reconstruction. All patients have made good progress since surgery. No patient requires a second procedure and none of the bone anchors have dislodged or loosened. We conclude that the Mitek bone anchor is a reliable technique to achieve soft tissue to bone fixation in central slip avulsion injuries. We recommend that this technique be considered as a treatment option for patients requiring surgical repair.

  7. High-mast light poles anchor nut loosening in Alaska : an investigation of field monitoring and finite-element analysis.

    Science.gov (United States)

    2014-09-01

    High mast lighting poles (HMLPs) are tall, roadside structures effective for lighting large areas of highways and intersections. The Alaska Department of Transportation : and Public Facilities (AKDOT&PF) maintains 118 such poles in the greater Anchor...

  8. Stone anchors (composite type) from the Saurshtra coast, India: An indicator of ancient ports and sea routes

    Digital Repository Service at National Institute of Oceanography (India)

    Gaur, A.S.; Sundaresh; Tripati, S.

    Marine archaeological investigations on the Saurashtra coast specially at Dwarka, Bet Dwarka, Armada and Somnath brought to light a large number of stone anchors of various type which include composite, grapnel and ring-stone types. The present...

  9. Clinical Outcome of a Wide-diameter Bone-anchored Hearing Implant and a Surgical Technique With Tissue Preservation

    DEFF Research Database (Denmark)

    Mowinckel, Marius S; Møller, Martin N; Wielandt, Kirsten N

    2016-01-01

    OBJECTIVE: To investigate the clinical outcome of a surgical technique with tissue preservation for a wide bone-anchored hearing implant concerning postoperative complications, skin reactions, implant loss, and implant stability. STUDY DESIGN: Consecutive, prospective case series. SETTING: Tertia...

  10. Peri-operative cerebrospinal fluid leak during single-stage bone-anchored hearing aid implantation: case report.

    Science.gov (United States)

    Dimbleby, G; Mitchell-Innes, A; Murphy, J

    2014-12-01

    A bone-anchored hearing aid uses the principle of bone conduction and osseointegration to transfer sound vibrations to a functioning inner ear. It consists of a permanent titanium implant, and removable abutment and sound processor. Informed consent requires discussion of the procedural benefits, alternatives and complications. The risks of bone-anchored hearing aid surgery include infection, soft tissue hypertrophy, skin graft or flap failure, osseointegration failure, and the need for further surgery. A case of cerebrospinal fluid leak in a patient undergoing bone-anchored hearing aid surgery is reported and discussed. Bone-anchored hearing aid surgery poses a risk of breaching the inner table of the temporal bone and dura, resulting in a cerebrospinal fluid leak; the risk of meningitis is rare but serious. The surgeon should discuss the possibility of cerebrospinal fluid leak when consenting patients. Pre-operative computerised tomography scanning should be considered in certain individuals to aid implant placement.

  11. ANTS-anchored Zn-Al-CO3-LDH particles as fluorescent probe for sensing of folic acid

    International Nuclear Information System (INIS)

    Liu, Pengfei; Liu, Dan; Liu, Yanhuan; Li, Lei

    2016-01-01

    A novel fluorescent nanosensor for detecting folic acid (FA) in aqueous media has been developed based on 8-aminonaphthalene-1,3,6-trisulfonate (ANTS) anchored to the surface of Zn-Al-CO 3 -layered double hydroxides (LDH) particles. The nanosensor showed high fluorescence intensity and good photostability due to a strong coordination interaction between surface Zn 2+ ions of Zn-Al-CO 3 -LDH and N atoms of ANTS, which were verified by result of X-ray photoelectron spectroscopy (XPS). ANTS-anchored on the surface of Zn-Al-CO 3 -LDH restricted the intra-molecular rotation leading to ANTS-anchored J-type aggregation emission enhancement. ANTS-anchored Zn-Al-CO 3 -LDH particles exhibited highly sensitive and selective response to FA over other common metal ions and saccharides present in biological fluids. The proposed mechanism was that oxygen atoms of -SO 3 groups in ANTS-anchored on the surface of Zn-Al-CO 3 -LDH were easily collided by FA molecules to form potential hydrogen bonds between ANTS-anchored and FA molecules, which could effectively quench the ANTS-anchored fluorescence. Under the simulated physiological conditions (pH of 7.4), the fluorescence quenching was fitted to Stern-Volmer equation with a linear response in the concentration range of 1 μM to 200 μM with a limit of detection of 0.1 μM. The results indicate that ANTS-anchored Zn-Al-CO 3 -LDH particles can afford a very sensitive system for the sensing FA in aqueous solution. - Highlights: • A novel fluorescent nanosensor has been developed. • The sensor exhibited highly sensitive and selective response to FA. • The fluorescence quenching was fitted to Stern–Volmer equation. • The linear response range was 1–200 μM with a limit of detection of 0.1 μM.

  12. Soft tissue overgrowth in bone-anchored hearing aid patients: use of 8.5 mm abutment.

    Science.gov (United States)

    Pelosi, S; Chandrasekhar, S S

    2011-06-01

    To review outcomes following implantation of an 8.5 mm bone-anchored hearing aid abutment, as regards post-operative management of scalp soft tissue overgrowth. Retrospective chart review of paediatric and adult patients implanted with bone-anchored hearing aids between 2003 and 2008 who subsequently underwent revision surgery for excessive soft tissue growth. A tertiary referral centre and a private otology and neurotology clinic. A total of 80 patients underwent bone-anchored hearing aid placement between 2003 and 2008. Of these patients, 14 had significant scalp soft tissue overgrowth unresponsive to first-line, nonsurgical local wound care. Fourteen patients underwent an average of 2.1 surgical procedures each for soft tissue overgrowth around their bone-anchored hearing aid abutment. The mean time between initial implantation and revision surgery was 13.6 months. Of these 14 patients, 11 were eventually fitted with an 8.5 mm abutment. Following placement of the longer abutment, only one patient required additional surgical reduction of soft tissue overgrowth (mean follow-up time 11.8 months). All patients were able to use their bone-anchored hearing aid. The 8.5 mm bone-anchored hearing aid abutment is successful in preventing the need for additional surgical intervention in the small but significant number of patients with post-implantation soft tissue overgrowth. Early consideration should be given to this option when first-line soft tissue care is inadequate.

  13. Binding constants of membrane-anchored receptors and ligands: A general theory corroborated by Monte Carlo simulations.

    Science.gov (United States)

    Xu, Guang-Kui; Hu, Jinglei; Lipowsky, Reinhard; Weikl, Thomas R

    2015-12-28

    Adhesion processes of biological membranes that enclose cells and cellular organelles are essential for immune responses, tissue formation, and signaling. These processes depend sensitively on the binding constant K2D of the membrane-anchored receptor and ligand proteins that mediate adhesion, which is difficult to measure in the "two-dimensional" (2D) membrane environment of the proteins. An important problem therefore is to relate K2D to the binding constant K3D of soluble variants of the receptors and ligands that lack the membrane anchors and are free to diffuse in three dimensions (3D). In this article, we present a general theory for the binding constants K2D and K3D of rather stiff proteins whose main degrees of freedom are translation and rotation, along membranes and around anchor points "in 2D," or unconstrained "in 3D." The theory generalizes previous results by describing how K2D depends both on the average separation and thermal nanoscale roughness of the apposing membranes, and on the length and anchoring flexibility of the receptors and ligands. Our theoretical results for the ratio K2D/K3D of the binding constants agree with detailed results from Monte Carlo simulations without any data fitting, which indicates that the theory captures the essential features of the "dimensionality reduction" due to membrane anchoring. In our Monte Carlo simulations, we consider a novel coarse-grained model of biomembrane adhesion in which the membranes are represented as discretized elastic surfaces, and the receptors and ligands as anchored molecules that diffuse continuously along the membranes and rotate at their anchor points.

  14. An approach to bilateral bone-anchored hearing aid surgery in children: contralateral placement of sleeper fixture.

    Science.gov (United States)

    Bernstein, J M; Sheehan, P Z

    2009-05-01

    Bone-anchored hearing aid surgery in younger children is a two-stage procedure, with a titanium fixture being allowed to osseointegrate for several months before an abutment is fitted through a skin graft. In the first procedure, it has been usual to place a reserve or sleeper fixture approximately 5 mm from the primary fixture as a backup in case the primary fixture fails to osseointegrate. This ipsilateral sleeper fixture is expensive, is often not used, and is placed in thinner calvarial bone where it is less likely to osseointegrate successfully. The authors have implanted the sleeper fixture on the contralateral side, with the additional objective of reducing the number of procedures for bilateral bone-anchored hearing aid implantation, providing a cost-effective use for the sleeper. The authors implanted the bone-anchored hearing aid sleeper fixture in the contralateral temporal bone instead of on the ipsilateral side in seven successive paediatric cases with bilateral conductive hearing loss requiring two-stage bone-anchored hearing aids, treated at the Royal Manchester Children's Hospital, UK. The seven patients ranged in age from five to 15 years, with a mean age of 10 years; in addition, a 20-year-old with learning disability was also treated. In each case, the contralateral sleeper fixture was not needed as a backup fixture, but was used in four patients (57 per cent) as the basis for a second-side bone-anchored hearing aid. In children with bilateral conductive hearing loss, in whom a bilateral bone-anchored hearing aid is being considered and the second side is to be operated upon at a later date, we recommend placing the sleeper fixture on the contralateral side at the time of primary first-side surgery. Our technique provides a sleeper fixture located in an optimal position, where it also offers the option of use for a second-side bone-anchored hearing aid and reduces the number of procedures needed.

  15. Widening higher education participation in rural communities in England: An anchor institution model

    Science.gov (United States)

    Elliott, Geoffrey

    2018-01-01

    Against a United Kingdom policy background of attempts to widen higher education participation in a socially inclusive direction, this article analyses theory, policy and practice to understand why past efforts have had limited success and to propose an alternative: an "anchor institution" model. A university and a private training provider were the principal partners in this venture, known as the South-West Partnership (pseudonym); the model was developed by them to meet the particular needs of mature female students who want and/or need to study part-time in a rural, coastal and isolated area of south-west England. While the concept of "anchor institutions" has previously been used in government social policy, and in higher education to promote knowledge transfer, it has not yet been adopted as a method for widening participation. The research study presented in this article investigated the effectiveness of the model in widening higher education participation in the context of the South-West Partnership. The study was conducted within an interpretivist theoretical framework. It accessed student voices to illustrate the character of education required to widen participation in vocational higher education by mature female students in rural communities, through semi-structured qualitative interviews on a range of topics identified from relevant theoretical literature, and by drawing on the research team's professional knowledge and experience. These topics included student aspirations and career destinations, motivations, access, learning experiences, and peer and tutor support. It is hoped the findings will inform the future development of adult vocational higher education provision in rural areas, where opportunities have been limited, and encourage further application of the anchor institution model for widening participation elsewhere.

  16. Stability Testing of a Wide Bone-Anchored Device after Surgery without Skin Thinning

    Directory of Open Access Journals (Sweden)

    Malou Hultcrantz

    2015-01-01

    Full Text Available Objective. To longitudinally follow the osseointegration using Resonance Frequency Analysis (RFA for different lengths of abutment on a new wide bone-anchored implant, introduced with the non-skin thinning surgical technique. Study Design. A single-center, prospective 1 year study following adults with bone-anchored hearing implants. Materials and Methods. Implantation was performed and followed for a minimum of 1 year. All patients were operated on according to the tissue preserving technique. A 4.5 mm wide fixture (Oticon Medical with varying abutments (9 to 12 mm was used and RFA was tested 1 week, 7 weeks, 6 months, and 12 months later. Implant Stability Quotient (ISQ, was measured from 1 to 100. Stability was compared to a group of patients (N=7 implanted with another brand (Cochlear BI400 of 4.5 mm fixtures. Results. All 10 adults concluded the study. None of the participants lost their implant during the test period indicating a good anchoring of abutments to the wide fixture tested. Stability testing was shown to vary depending on abutment length and time after surgery and with higher values for shorter abutments and increasing values over the first period of time. One patient changed the abutment from 12 to 9 mm and another from a 9 to a 12 during the year. No severe skin problems, numbness around the implant, or cosmetic problems arose. Conclusion. After 1 year of follow-up, combination of a wide fixture implant and the non-skin thinning surgical technique indicates a safe procedure with good stability and no abutment losses.

  17. Retrospective Evaluation of Surgical Anatomical Repair of Distal Biceps Brachii Tendon Rupture Using Suture Anchor Fixation.

    Science.gov (United States)

    Witkowski, Jarosław; Królikowska, Aleksandra; Czamara, Andrzej; Reichert, Paweł

    2017-10-17

    BACKGROUND To date, no consensus has been reached regarding the preferred fixation method to use in the repair of distal biceps brachii tendon rupture. The aim of this study was to clinically and functionally (Mayo Elbow Performance Index, MEPI) assess the upper limb after surgical anatomic reinsertion of the distal biceps brachii tendon with the use of suture anchor fixation method with regard to postoperative time and limb dominance, and to assess postoperative complications. MATERIAL AND METHODS The sample comprised 18 males (age 52.09±8.89 years) after surgical anatomical distal biceps brachii reinsertion using suture anchor fixation. A comprehensive clinical and functional evaluation and pain assessment were performed. RESULTS In terms of postoperative complications, an isolated case of surgical site sensory disturbances was noted. Circumferences (p-value 0.21-1.00) and ROM (p-value 0.07-1.00) were similar in the operated and nonoperated limbs. The isometric torque (IT) values of muscles flexing and supinating the forearm were comparable in both limbs (p-value 0.14-0.95), but in patients with the operated dominant limb, the mean IT value was not higher than the value obtained in the nonoperated nondominant one. The MEPI indicated good and excellent results (80.00±15.00-90.00±8.66 points), but a detailed individual analysis showed that reported scores were not in line with objectively measured features. CONCLUSIONS The results of the comprehensive retrospective evaluation justify the clinical use of suture anchors fixation method in the surgical anatomical reinsertion of a ruptured distal biceps brachii tendon. The assessment of a patient should always report both subjective and objective measures.

  18. The role of bone anchored hearing aids in children with Down syndrome.

    Science.gov (United States)

    McDermott, Ann-Louise; Williams, Jo; Kuo, Michael J; Reid, Andrew P; Proops, David W

    2008-06-01

    To evaluate complication rates and outcomes of children with Down syndrome fitted with a Bone Anchored Hearing Aid (Baha). To evaluate whether the Bone Anchored Hearing Aid is a successful form of aural rehabilitation in children with Down syndrome from a patients' perspective. Retrospective case analysis and postal questionnaire study. The Birmingham Children's Hospital, UK. A total of 15 children were fitted with a Baha between February 1992 and February 2007. The age range was 2-15 years. A postal questionnaire was sent to each family. The Glasgow Children's Benefit Inventory (GCBI) was used in this study. Implantation results, skin reactions and other complications were recorded. Quality of life after receiving a Baha was assessed with the GCBI. All 15 patients are using their Baha 7 days a week for more than 8h a day after a follow-up of 14 months with continuing audiological benefit. No fixtures were lost, and skin problems were encountered in 3 (20%). Regarding quality of life, all 15 patients had improved social and physical functioning as a result of better hearing. Baha has an important role in the overall management of individuals with Down syndrome after conventional hearing aids and/or ventilation tubes have been considered or already failed. This study has shown a 20% rate of soft tissue reaction and there were no fixture losses in this group. No significant increase in complication rates was identified in children with Down syndrome. Finally, there was a significantly improved quality of life in children with Down syndrome after receiving their Baha. There was a high patient/carer satisfaction with Baha. Two of our series had bilateral two stage fixture procedures without any complications. More consideration should be given to bilateral bone anchored hearing aids in this group.

  19. Aspartate tightens the anchoring of staphylococcal lipoproteins to the cytoplasmic membrane.

    Science.gov (United States)

    Kumari, Nimerta; Götz, Friedrich; Nguyen, Minh-Thu

    2017-12-01

    In gram-negative bacteria, the ABC transporter LolCDE complex translocates outer membrane-specific lipoproteins (Lpp) from the inner membrane to the outer membrane. Lpp possessing aspartate (Asp) at position +2 are not translocated because it functions as a LolCDE avoidance signal. In gram-positive bacteria, lacking an outer membrane and the Lol system, Lpp are only anchored at the outer leaflet of the cytoplasmic membrane. However, the release of Lpp particularly in pathogenic or commensal species is crucial for immune modulation. Here, we provide evidence that in Staphylococcus aureus Asp at position +2 plays a role in withholding Lpp to the cytoplasmic membrane. Screening of published exoproteomic data of S. aureus revealed that Lpp mainly with Gly or Ser at position +2 were found in exoproteome, but there was no Lpp with Asp+2. The occurrence of Lpp with Asp+2 is infrequent in gram-positive bacteria. In S. aureus USA300 only seven of the 67 Lpp possess Asp+2; among them five Lpp represented Lpl lipoproteins involved in host cell invasion. Our study demonstrated that replacing the Asp+2 present in Lpl8 with a Ser enhances its release into the supernatant. However, there is no different release of Asp+2 and Ser+2 in mprF mutant that lacks the positive charge of lysyl-phosphatidylglycerol (Lys-PG). Moreover, substitution of Ser+2 by Asp in SitC (MntC) did not lead to a decreased release indicating that in staphylococci positions +3 and +4 might also be important for a tighter anchoring of Lpp. Here, we show that Asp in position +2 and adjacent amino acids contribute in tightening the anchoring of Lpp by interaction of the negative charged Asp with the positive charged Lys-PG. © 2017 The Authors. MicrobiologyOpen published by John Wiley & Sons Ltd.

  20. The Naturalized Nation: Anchoring, Objectification and Naturalized Social Representations of History

    Directory of Open Access Journals (Sweden)

    Eemeli Hakoköngäs

    2016-12-01

    Full Text Available This study focuses on the connection between social representations of history and collective memory from the perspective of elementary concepts of social representations theory: anchoring, objectification and naturalization. The aims of the study are to arrive at a conceptual clarity of this connection and demonstrate how to apply basic concepts of social representations theory to the study of collective memory. The study also focuses on the naturalized characteristics of Finnish history. The data consist of the covers of twenty Finnish history books between the years 1965 and 2014. All the covers are embellished with typography or visual images. The covers were analysed using a semiotic approach in which the interest is in the description (denotation, the associations (connotation and the meaning system these construe (myth. The analysis shows how national history is concretized with visual images (objectification, how the meaning of representation is conveyed (anchoring and how collective memory is maintained (naturalization, transmitted and shaped during the years. The results show how the stable collective memories and changing social representations of history are interacting. The most frequently used visual element was the colour blue, which alludes to the Finnish flag, a symbol of the nation that represents the core of Finnish history. The study suggests that it is possible to conceptualize collective memories as naturalized social representations of history. It shows how processes of anchoring and objectification serve as tools of collective memory and how the naturalized conceptions are subtly changed. In addition, the study develops the use of visual semiotic analysis in social representations research.

  1. Exoskeleton anchoring to tendon cells and muscles in molting isopod crustaceans

    Directory of Open Access Journals (Sweden)

    Nada Žnidaršič

    2012-03-01

    Full Text Available Specialized mechanical connection between exoskeleton and underlying muscles in arthropods is a complex network of interconnected matrix constituents, junctions and associated cytoskeletal elements, which provides prominent mechanical attachment of the epidermis to the cuticle and transmits muscle tensions to the exoskeleton. This linkage involves anchoring of the complex extracellular matrix composing the cuticle to the apical membrane of tendon cells and linking of tendon cells to muscles basally. The ultrastructural arhitecture of these attachment complexes during molting is an important issue in relation to integument integrity maintenance in the course of cuticle replacement and in relation to movement ability. The aim of this work was to determine the ultrastructural organization of exoskeleton – muscles attachment complexes in the molting terrestrial isopod crustaceans, in the stage when integumental epithelium is covered by both, the newly forming cuticle and the old detached cuticle. We show that the old exoskeleton is extensively mechanically connected to the underlying epithelium in the regions of muscle attachment sites by massive arrays of fibers in adult premolt Ligia italica and in prehatching embryos and premolt marsupial mancas of Porcellio scaber. Fibers expand from the tendon cells, traverse the new cuticle and ecdysal space and protrude into the distal layers of the detached cuticle. They likely serve as final anchoring sites before exuviation and may be involved in animal movements in this stage. Tendon cells in the prehatching embryo and in marsupial mancas display a substantial apicobasally oriented transcellular arrays of microtubules, evidently engaged in myotendinous junctions and in apical anchoring of the cuticular matrix. The structural framework of musculoskeletal linkage is basically established in described intramarsupial developmental stages, suggesting its involvement in animal motility within the marsupium.

  2. Display of GPI-anchored anti-EGFR nanobodies on extracellular vesicles promotes tumour cell targeting

    Directory of Open Access Journals (Sweden)

    Sander A. A. Kooijmans

    2016-03-01

    Full Text Available Background: Extracellular vesicles (EVs are attractive candidate drug delivery systems due to their ability to functionally transport biological cargo to recipient cells. However, the apparent lack of target cell specificity of exogenously administered EVs limits their therapeutic applicability. In this study, we propose a novel method to equip EVs with targeting properties, in order to improve their interaction with tumour cells. Methods: EV producing cells were transfected with vectors encoding for anti-epidermal growth factor receptor (EGFR nanobodies, which served as targeting ligands for tumour cells, fused to glycosylphosphatidylinositol (GPI anchor signal peptides derived from decay-accelerating factor (DAF. EVs were isolated using ultrafiltration/size-exclusion liquid chromatography and characterized using western blotting, Nanoparticle Tracking Analysis, and electron microscopy. EV–tumour cell interactions were analyzed under static conditions using flow cytometry and under flow conditions using a live-cell fluorescence microscopy-coupled perfusion system. Results: V analysis showed that GPI-linked nanobodies were successfully displayed on EV surfaces and were highly enriched in EVs compared with parent cells. Display of GPI-linked nanobodies on EVs did not alter general EV characteristics (i.e. morphology, size distribution and protein marker expression, but greatly improved EV binding to tumour cells dependent on EGFR density under static conditions. Moreover, nanobody-displaying EVs showed a significantly improved cell association to EGFR-expressing tumour cells under flow conditions. Conclusions: We show that nanobodies can be anchored on the surface of EVs via GPI, which alters their cell targeting behaviour. Furthermore, this study highlights GPI-anchoring as a new tool in the EV toolbox, which may be applied for EV display of a variety of proteins, such as antibodies, reporter proteins and signaling molecules.

  3. Widening higher education participation in rural communities in England: An anchor institution model

    Science.gov (United States)

    Elliott, Geoffrey

    2018-02-01

    Against a United Kingdom policy background of attempts to widen higher education participation in a socially inclusive direction, this article analyses theory, policy and practice to understand why past efforts have had limited success and to propose an alternative: an "anchor institution" model. A university and a private training provider were the principal partners in this venture, known as the South-West Partnership (pseudonym); the model was developed by them to meet the particular needs of mature female students who want and/or need to study part-time in a rural, coastal and isolated area of south-west England. While the concept of "anchor institutions" has previously been used in government social policy, and in higher education to promote knowledge transfer, it has not yet been adopted as a method for widening participation. The research study presented in this article investigated the effectiveness of the model in widening higher education participation in the context of the South-West Partnership. The study was conducted within an interpretivist theoretical framework. It accessed student voices to illustrate the character of education required to widen participation in vocational higher education by mature female students in rural communities, through semi-structured qualitative interviews on a range of topics identified from relevant theoretical literature, and by drawing on the research team's professional knowledge and experience. These topics included student aspirations and career destinations, motivations, access, learning experiences, and peer and tutor support. It is hoped the findings will inform the future development of adult vocational higher education provision in rural areas, where opportunities have been limited, and encourage further application of the anchor institution model for widening participation elsewhere.

  4. Audiological and subjective benefit results in bone-anchored hearing device users.

    Science.gov (United States)

    Boleas-Aguirre, Maria Soledad; Bulnes Plano, Maria Dolores; de Erenchun Lasa, Iñigo Ruiz; Ibáñez Beroiz, Berta

    2012-06-01

    Audiological and subjective benefits in adult bone-anchored hearing device users. Retrospective evaluation. Tertiary referral center. Thirty-eight adult subjects fitted with unilateral bone-anchored hearing device. Audiometric measurements included sound-field pure-tone and speech audiometries (speech reception threshold, maximum speech discrimination). Subjective benefit was assessed by the Abbreviated Profile of Hearing Aid Benefit (APHAB) questionnaire. Ipsilateral and contralateral hearing loss was considered. Comparison was drawn between Compact, Divino, and Intenso processors. To compare sound-field pure-tone and speech audiometries and APHAB results with and without the device adjusted for the unaided results. With the device, sound-field pure-tone audiometry results revealed an increase gain in all frequencies. Sound-field speech audiometry showed that the mean threshold of speech recognition was 20 dB lower, maximum discrimination was attained at 5 dB less, and percentage of maximum discrimination increased by 5%. Scores in the APHAB questionnaire decreased except for the aversiveness subscale. Auditory-adjusted gain showed greater benefit in subjects with ipsilateral conductive hearing loss.Subjects with contralateral normal hearing or conductive hearing loss showed greater improvement that those with contralateral mixed or sensorineural hearing loss. There were no differences between Compact, Divino and Intenso processors. When comparisons are adjusted for unaided condition, the bone-anchored hearing device provided auditory and subjective benefit in subjects with ipsilateral conductive hearing loss and contralateral normal hearing or conductive hearing loss. It gave marginal benefit in ipsilateral mixed and contralateral mixed or sensorineural hearing loss. No differences were found between the Compact, Intenso, and Divino processors.

  5. A measure of variable planar locations anchored on the centroid of the vowel space

    DEFF Research Database (Denmark)

    Watt, Dominic; Fabricius, Anne

    2011-01-01

    as an anchor point or vertex for calculation of planar locations on formant plots, permitting quantification of the distribution of vowel tokens within the space. This information, along with details such as Euclidean distances, can then be used to precisely pinpoint the trajectories of diachronic change...... of desiderata for choice of normalization algorithm(s) based on replicable procedures. We then present the principles of centroid-based normalization and account for its performance in recent road tests. In sections 4 and 5 we introduce a method that utilizes the centroid of the speaker’s vowel space...

  6. Estimating escapement of fish and invertebrates in a Danish anchor seine

    DEFF Research Database (Denmark)

    Noack, Thomas; Madsen, Niels; Mieske, Bernd

    2017-01-01

    The codend is generally presumed to be the place where the main selectivity of fish occurs in towed fishing gears, but other parts of the net have been found to contribute to the selectivity process of several invertebrate species. This means that conventional selectivity or survival studies may...... ignore the selectivity of net parts other than the codend for certain species. By attaching 12 small meshed collecting bags to different parts of a Danish anchor seine net and conducting normal commercial fishing activities, this study showed that there is a substantial escapement of fish and (especially...

  7. Sustaining area-based initiatives by developing appropriate "anchors": the role of social capital

    DEFF Research Database (Denmark)

    Agger, Annika; Roy, Parama; Leonardsen, Oystein

    2016-01-01

    and an empirical examination of three different cases from an ABI in Copenhagen, the paper highlights why and how particular models of ‘anchors’ develop in specific local contexts. We conclude by emphasizing the value of the lens of social capital, particularly, in the ABIs’ strategic efforts towards ‘anchoring’.......This paper focuses on ‘anchoring,’ understood as the process of building project-based organizational networks, or ‘anchors’, in order to sustain the efforts of area-based initiatives (ABIs) after they leave their targeted neighbourhoods. Drawing on the scholarly literature on social capital...

  8. Effect of torsion angle on electronic transport through different anchoring groups in molecular junction

    International Nuclear Information System (INIS)

    Xia Caijuan; Fang Changfeng; Zhao Peng; Xie Shijie; Liu Desheng

    2009-01-01

    By applying nonequilibrium Green's function formalism combined with first-principles density functional theory, we investigate effect of torsion angle on electronic transport properties of 4,4 ' -biphenyl molecule connected with different anchoring groups (dithiocarboxylate and thiol group) to Au(111) electrodes. The influence of the HOMO-LUMO gaps and the spatial distributions of molecular orbitals on the quantum transport through the molecular device are discussed. Theoretical results show that the torsion angle plays important role in conducting behavior of molecular devices. By changing the torsion angle between two phenyl rings, namely changing the magnitude of the intermolecular coupling effect, a different transport behavior can be observed in these two systems.

  9. Identification of Soil Models by Simulation of Ground Anchor Tests, Using FEM

    OpenAIRE

    Aliciuc, Constantin-Lucian; Muşat, Vasile

    2013-01-01

    Several types of soil models have been developed during time in order to simulate the soil behavior in finite element (FEM) analysis, so choosing the right soil model has a great importance on results. This study presents a method to establish the most suitable soil model used in FEM in order to calculate a temporary anchored retaining structure, method which is based on field tests. The test fields are simulated with FEM and are used several types of soil models, taken into consideration the...

  10. LATCH (Lower Anchors and Tethers for CHildren) usability in school buses and passenger vehicles.

    Science.gov (United States)

    Rudin-Brown, Christina M; Scipione, Andrea; Armstrong, Joe; Lai, Gerald; Salway, Alice; Kumagai, Jason

    2008-10-01

    The present study was designed to assess LATCH (Lower Anchors and Tethers for CHildren) usability in both cars and school buses. Despite being designed to make child restraint system (CRS) installation in vehicles easier and with fewer opportunities for misuse, there have been reports that LATCH is not as easy to use, or as effective, as hoped. To date, there have been few systematic or experimental studies evaluating LATCH usability. Further, based on research demonstrating that small children in school buses are not protected from injury in the same manner as larger children, motor vehicle safety regulations now require LATCH anchorages to be installed on a proportion of seats in all school buses, allowing for the installation of CRS. The main objectives of the study were to assess LATCH usability in cars and school buses and to make recommendations to improve its design and labeling. Forty-eight paid participants (younger vs. older; experienced vs. not experienced) installed CRS in a car and a school bus using three different types of lower anchorage connectors and top tethers. Dependent measures included time to install and remove the CRS, frequency and seriousness of errors, and subjective usability reports. Surprisingly, many participants were not familiar with the LATCH system and believed that CRS should only be installed using the seat belt. Over 40% of participants did not know where the lower anchorage connectors were located in the car. While installation performance using LATCH was generally satisfactory (all CRS were installed correctly between 70 and 92% of the time), LATCH design improvements in terms of the CRS and both vehicles were identified. The study results generated a number of recommended design improvements that would improve LATCH usability in cars and school buses. These include: 1) clearly identifying LATCH anchors in both vehicle types by using clear, conspicuous labels or pictograms; 2) making LATCH anchors in all vehicles more

  11. Research on Anchorage Performance of Grouting Anchor Connection of Precast Concrete Structure

    Science.gov (United States)

    Wang, Donghui; Liu, Xudong; Wang, Sheng; Cao, Xixi

    2018-03-01

    The bonding of grouted anchor bars is one of the vertical connection forms of steel bars in fabricated concrete structures. The performance of grouted connection is mainly affected by the anchorage length and lap length of steel bars. The mechanisms of bond and anchorage between steel bar and concrete are analyzed, and the factors that influence the anchorage performance of steel bar are systematically summarized. Results show that the bond and anchorage performance of steel and concrete have been studied widely, but there are still shortcomings, and the connection forms need to be further improved.

  12. Neutron reflectivity of supported membranes incorporating terminally anchored polymers: Protrusions vs. blisters

    DEFF Research Database (Denmark)

    Fragneto, Giovanna; Halperin, Avraham; Klösgen-Buchkremer, Beate Maria

    2013-01-01

    The effect of terminally anchored chains on the structure of lipid bilayers adsorbed at the solid/water interface was characterized by neutron reflectivity. In the studied system, the inner leaflet, closer to the substrate, consisted of head-deuterated 1,2-distearoyl-sn-glycero-3-phosphorylcholine...... (DSPC) and the outer leaflet comprised a mixture of DSPC and polyethylene glycol (PEG) functionalized 1,2-distearoyl-sn-glycero-3-phosphoethanolamine. The DSPC headgroups were deuterated to enhance sensitivity and demarcate the bilayer/water interface. The effect on the inner and outer headgroup layers...

  13. Installation process of suction anchors in Gulf of Guinea clay : Centrifuge modelling

    OpenAIRE

    THOREL, Luc; GARNIER, Jacques; RAULT, Gérard; DENDANI, Hédi; COLLIAT, JL

    2010-01-01

    The preparation process of a deepwater Gulf of Guinea clay for modelling of 24 m long suction anchors at a scale of 1/100 in the LCPC centrifuge, the clay characteristics and the installation phase (self-weight and suction) are presented. Two types of caissons have been tested in each tub : one with stiffeners and the other without stiffener. The embedment ratio is close to the suction caisson's slenderness of 3. An analysis of the forces of suction and soil friction shows, as expected, hi...

  14. Bone-anchored hearing aid implantation in a patient with Goldenhar syndrome.

    Science.gov (United States)

    Santarelli, Griffin; Redfern, Roberta E; Benson, Aaron G

    2015-12-01

    Patients with Goldenhar syndrome exhibit a number of characteristic symptoms, including middle and internal ear malformations that may cause profound hearing loss. Bone-anchored hearing aids have been used to treat these patients in the past, although complications may arise due to the nature of the disease. Herein we present the case of a pediatric patient with Goldenhar syndrome whose hearing aid abutment extruded spontaneously because of poor bone quality, despite adequate thickness. We provide a brief review of the literature and suggest a flexible surgical plan for any syndromic pediatric patient.

  15. Anchoring Effect and Spin-offs: A Case Study of Taiwan Companies, Asus and Yulon

    OpenAIRE

    Yu-Wei Lan; Dan Lin; Lu Lin

    2015-01-01

    This study uses a case study method to examine the spin-offs of Asus and Yulon. Both companies show negative cumulated abnormal returns after spin-off announcements and then return to the anchoring price as at the announcement day. The results are in contrast to the findings of Veld et al. (2004) and Schipper and Smith (1986). However, our results are consistent with Nanda¡¯s (1991) asymmetric information argument. Nanda (1991) suggests that the negative returns on the announcement day reflec...

  16. A Tenebrio molitor GPI-anchored alkaline phosphatase is involved in binding of Bacillus thuringiensis Cry3Aa to brush border membrane vesicles.

    Science.gov (United States)

    Zúñiga-Navarrete, Fernando; Gómez, Isabel; Peña, Guadalupe; Bravo, Alejandra; Soberón, Mario

    2013-03-01

    Bacillus thuringiensis Cry toxins recognizes their target cells in part by the binding to glycosyl-phosphatidyl-inositol (GPI) anchored proteins such as aminopeptidase-N (APN) or alkaline phosphatases (ALP). Treatment of Tenebrio molitor brush border membrane vesicles (BBMV) with phospholipase C that cleaves out GPI-anchored proteins from the membranes, showed that GPI-anchored proteins are involved in binding of Cry3Aa toxin to BBMV. A 68 kDa GPI-anchored ALP was shown to bind Cry3Aa by toxin overlay assays. The 68 kDa GPI-anchored ALP was preferentially expressed in early instar larvae in comparison to late instar larvae. Our work shows for the first time that GPI-anchored ALP is important for Cry3Aa binding to T. molitor BBMV suggesting that the mode of action of Cry toxins is conserved in different insect orders. Copyright © 2012 Elsevier Inc. All rights reserved.

  17. Design of Ru(II) sensitizers endowed by three anchoring units for adsorption mode and light harvesting optimization

    International Nuclear Information System (INIS)

    Lobello, Maria Grazia; Fantacci, Simona; Manfredi, Norberto; Coluccini, Carmine; Abbotto, Alessandro; Nazeeruddin, Mohammed K.; De Angelis, Filippo

    2014-01-01

    We report the design, synthesis and computational investigation of a class of Ru(II)-dyes based on mixed bipyridine ligands for use in dye-sensitized solar cells. These dyes are designed to preserve the optimal anchoring mode of the prototypical N719 sensitizer by three carboxylic groups, yet allowing for tunable optimization of their electronic and optical properties by selective substitution at one of the 4-4′ positions of a single bipyridine ligand with π-excessive heteroaromatic groups. We used Density Functional Theory/Time Dependent Density Functional Theory calculations to analyze the electronic structure and optical properties of the dye and to investigate the dye adsorption mode on a TiO 2 nanoparticle model. Our results show that we are effectively able to introduce three carboxylic anchoring units into the dye and achieve at the same time an enhanced dye light harvesting, demonstrating the design concept. As a drawback of this type of dyes, the synthesis leads to a mixture of dye isomers, which are rather tedious to separate. - Highlights: • We designed heteroleptic Ru(II) sensitizers with three carboxylic anchoring groups. • The three carboxylic anchoring groups are essential for high open circuit potentials. • Introduction of the mixed bipyridine ligand increases the dye light absorption. • Computational simulations confirm the three anchoring sites on TiO 2

  18. Design of Ru(II) sensitizers endowed by three anchoring units for adsorption mode and light harvesting optimization

    Energy Technology Data Exchange (ETDEWEB)

    Lobello, Maria Grazia; Fantacci, Simona [Computational Laboratory for Hybrid/Organic Photovoltaics (CLHYO), Istituto CNR di Scienze e Tecnologie Molecolari, Via elce di Sotto 8, I-06213 Perugia (Italy); Manfredi, Norberto; Coluccini, Carmine [Department of Materials Science and Milano-Bicocca Solar Energy Research Center-MIB-Solar, University of Milano-Bicocca and INSTM, Via Cozzi 53, I-20125 Milano (Italy); Abbotto, Alessandro, E-mail: alessandro.abbotto@unimib.it [Department of Materials Science and Milano-Bicocca Solar Energy Research Center-MIB-Solar, University of Milano-Bicocca and INSTM, Via Cozzi 53, I-20125 Milano (Italy); Nazeeruddin, Mohammed K., E-mail: mdkhaja.nazeeruddin@epfl.ch [Laboratory for Photonics and Interfaces, Station 6, Institute of Chemical Sciences and Engineering, School of Basic Sciences, Swiss Federal Institute of Technology, CH-1015 Lausanne (Switzerland); De Angelis, Filippo, E-mail: filippo@thch.unipg.it [Computational Laboratory for Hybrid/Organic Photovoltaics (CLHYO), Istituto CNR di Scienze e Tecnologie Molecolari, Via elce di Sotto 8, I-06213 Perugia (Italy)

    2014-06-02

    We report the design, synthesis and computational investigation of a class of Ru(II)-dyes based on mixed bipyridine ligands for use in dye-sensitized solar cells. These dyes are designed to preserve the optimal anchoring mode of the prototypical N719 sensitizer by three carboxylic groups, yet allowing for tunable optimization of their electronic and optical properties by selective substitution at one of the 4-4′ positions of a single bipyridine ligand with π-excessive heteroaromatic groups. We used Density Functional Theory/Time Dependent Density Functional Theory calculations to analyze the electronic structure and optical properties of the dye and to investigate the dye adsorption mode on a TiO{sub 2} nanoparticle model. Our results show that we are effectively able to introduce three carboxylic anchoring units into the dye and achieve at the same time an enhanced dye light harvesting, demonstrating the design concept. As a drawback of this type of dyes, the synthesis leads to a mixture of dye isomers, which are rather tedious to separate. - Highlights: • We designed heteroleptic Ru(II) sensitizers with three carboxylic anchoring groups. • The three carboxylic anchoring groups are essential for high open circuit potentials. • Introduction of the mixed bipyridine ligand increases the dye light absorption. • Computational simulations confirm the three anchoring sites on TiO{sub 2}.

  19. Relation between anchorings of liquid crystals and conformation changes in aligning agents by the Langmuir-Blodgett film technique investigation

    International Nuclear Information System (INIS)

    Zhu, Y.; Lu, Z.; Wei, Y.

    1995-01-01

    The anchoring direction of liquid crystals on a solid substrate surface depends upon many parameters characterizing the liquid-crystal--substrate interface, a variation of which may change this anchoring direction leading to the so-called anchoring transition. Here, based on the Langmuir-Blodgett film technique, we present two model systems to study the relation between anchoring directions and the conformation changes in aligning agents. A double-armed crown ether liquid crystal and a side chain polymer liquid crystal at an air-water interface both show phase transitions, accompanied by conformation changes. However, when the monolayers in different phases were transferred onto solid substrates to orient liquid crystals, we found that for the crown ether material the conformation change can alter the anchoring of liquid crystals between homeotropic and homogeneous alignments, while for the polymer liquid crystal, despite the conformation changes, the liquid crystals can only be aligned homeotropically. The involved mechanisms were briefly discussed in terms of the Landau-type phenomenological theory

  20. AKAP18:PKA-RIIα structure reveals crucial anchor points for recognition of regulatory subunits of PKA.

    Science.gov (United States)

    Götz, Frank; Roske, Yvette; Schulz, Maike Svenja; Autenrieth, Karolin; Bertinetti, Daniela; Faelber, Katja; Zühlke, Kerstin; Kreuchwig, Annika; Kennedy, Eileen J; Krause, Gerd; Daumke, Oliver; Herberg, Friedrich W; Heinemann, Udo; Klussmann, Enno

    2016-07-01

    A-kinase anchoring proteins (AKAPs) interact with the dimerization/docking (D/D) domains of regulatory subunits of the ubiquitous protein kinase A (PKA). AKAPs tether PKA to defined cellular compartments establishing distinct pools to increase the specificity of PKA signalling. Here, we elucidated the structure of an extended PKA-binding domain of AKAP18β bound to the D/D domain of the regulatory RIIα subunits of PKA. We identified three hydrophilic anchor points in AKAP18β outside the core PKA-binding domain, which mediate contacts with the D/D domain. Such anchor points are conserved within AKAPs that bind regulatory RII subunits of PKA. We derived a different set of anchor points in AKAPs binding regulatory RI subunits of PKA. In vitro and cell-based experiments confirm the relevance of these sites for the interaction of RII subunits with AKAP18 and of RI subunits with the RI-specific smAKAP. Thus we report a novel mechanism governing interactions of AKAPs with PKA. The sequence specificity of each AKAP around the anchor points and the requirement of these points for the tight binding of PKA allow the development of selective inhibitors to unequivocally ascribe cellular functions to the AKAP18-PKA and other AKAP-PKA interactions. © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society.

  1. Strengthening of existing concrete dams using post-tensioned anchors: a state-of-the-art review

    International Nuclear Information System (INIS)

    Xu, H.; Benmokrane, B.

    1996-01-01

    Many old dams are in need of strengthening and rehabilitation as a result of aging, deterioration, deficiencies in design and construction, and more stringent safety standards. Post-tensioned anchors are the most practical and cost-effective method of strengthening existing dams subjected to direct tension, sliding, overturning and seismic loading. Post-tensioning technique requires minimum demolition, has only a minor impact on the dam, and is relatively inexpensive using a small number of anchors. About 60 case histories of concrete dams strengthened by post-tensioned anchors were reviewed. The reasons for strengthening were analyzed, and the general design, construction, drilling, grouting, testing, and performance of post-tensioned anchors were outlined. Principal reasons for using post-tensioned anchors were: (1) increasing spillway capacity and dam stability, (2) raising dam height for great storage, (3) upgrading dams to new safety standards, (4) remedying the deficiencies in design, (5) stabilizing concrete cracks, (6) strengthening dam abutments, and (7) reinforcing lock walls or building blocks into coffer dams. 72 refs., 12 figs., 6 tabs

  2. Correction of Sunken Upper Eyelids by Anchoring the Central Fat Pad to the Medial Fat Pad during Upper Blepharoplasty

    Directory of Open Access Journals (Sweden)

    Myeong Su Jeon

    2015-07-01

    Full Text Available BackgroundMany methods have been proposed for the correction of sunken upper eyelids. These methods include surgical treatments, such as micro-fat, dermofat, or fascia-fat grafts, or the use of alloplastic materials. Here, we present our experience of sunken upper eyelid correction involving the simple addition of anchoring the central fat pad to the medial fat pad during upper blepharoplasty.MethodsWe performed 74 cases of upper blepharoplasty with sunken upper eyelid correction between October 2013 and September 2014. The lateral portion of the central fat pad was partially dissected to facilitate anchoring. The medial fat pad was gently exposed and then pulled out to facilitate anchoring. After the rotation of the dissected lateral portion of the central fat pad by 180° to the medial side, it was anchored spreading to the medial fat pad. Photographs taken at 6 months postoperatively were presented to three physicians for objective assessment. Of the 74 patients, 54 patients followed at 6 months postoperatively were included in this retrospective, objective assessment.ResultsSunken eyelids were effectively corrected in 51 of the 54 patients, but 3 had minimal effect because preaponeurotic fat pads had been removed during previous upper blepharoplasty. In addition to correcting sunken eyelids, lateral bulging was corrected and a better definition of the lateral portion of upper lid creases was obtained.ConclusionsAnchoring the central fat pad to the medial fat pad provides an effective means of correcting sunken upper eyelids during upper blepharoplasty.

  3. Influence of Self-generated Anchors on the Voice Handicap Index-10 (VHI-10).

    Science.gov (United States)

    Canals-Fortuny, Elisabet; Vila-Rovira, Josep

    2017-03-01

    The aim of this research is to study whether the presentation of the Voice Handicap Index-10 questionnaire administered at the beginning of the treatment impinged on the results of the responses from the end of the treatment. The questionnaire was administered at the beginning of the treatment to a total of 308 patients. After the treatment, a group of 235 patients answered the questionnaire again without any reference to their responses on the initial administration. The other group of participants, consisting of 73 subjects, completed the questionnaire with the answer sheet of their initial self-assessment in sight. The data obtained show that patients who responded to the anchored answer test show less dispersion and a smaller coefficient of variation (0.90) than those who responded to the nonanchored answer test (coefficient of variation = 1.66). The method of administration of the Voice Handicap Index-10 at the end of a treatment influences the dispersion of the results. We recommend that the patient be anchored to the initial answer sheet while responding to the final self-assessment. Copyright © 2017 The Voice Foundation. Published by Elsevier Inc. All rights reserved.

  4. Impact of Anchoring Groups on Ballistic Transport: Single Molecule vs Monolayer Junctions

    Science.gov (United States)

    2015-01-01

    Tuning the transport properties of molecular junctions by chemically modifying the molecular structure is one of the key challenges for advancing the field of molecular electronics. In the present contribution, we investigate current–voltage characteristics of differently linked metal–molecule–metal systems that comprise either a single molecule or a molecular assembly. This is achieved by employing density functional theory in conjunction with a Green’s function approach. We show that the conductance of a molecular system with a specific anchoring group is fundamentally different depending on whether a single molecule or a continuous monolayer forms the junction. This is a consequence of collective electrostatic effects that arise from dipolar elements contained in the monolayer and from interfacial charge rearrangements. As a consequence of these collective effects, the “ideal” choice for an anchoring group is clearly different for monolayer and single molecule devices. A particularly striking effect is observed for pyridine-docked systems. These are subject to Fermi-level pinning at high molecular packing densities, causing an abrupt increase of the junction current already at small voltages. PMID:26401191

  5. Design of a wireless anchoring and extending micro robot system for gastrointestinal tract.

    Science.gov (United States)

    Lin, Wei; Shi, Yuting; Jia, Zhiwei; Yan, Guozheng

    2013-06-01

    Diagnosis and treatment using a conventional endoscope in the gastrointestinal (GI) tract are very common nowadays. However, endoscopy has some disadvantages. This paper describes a wireless micro-robot for active locomotion in the GI tract. After design and analysis of the anchoring-extending gait, two mechanisms were developed to meet the gait requirements. These actuation and transmission mechanisms were demonstrated in detail to explain the gait implementation. The mechanisms were driven by a micro-brush direct current motor with a micro-normal module (m = 0.2 mm) gearbox. The force of the mechanisms was tested to guarantee the sufficiency of the gait and the safety of the robot. After mounting a dedicated video capture unit and wireless power receiving coils, in vitro experiments were conducted to show the feasibility of locomotion by wireless power supply. The assembled micro-robot was 13 mm in diameter and 90 mm in length, with a velocity of 1 mm/s at 500 mW power consumption. The proposed anchoring and extending intestinal micro-robot met the requirements of intestinal disease diagnosis and treatment. Copyright © 2012 John Wiley & Sons, Ltd.

  6. Note on the hydrodynamic description of thin nematic films: Strong anchoring model

    KAUST Repository

    Lin, Te-Sheng

    2013-01-01

    We discuss the long-wave hydrodynamic model for a thin film of nematic liquid crystal in the limit of strong anchoring at the free surface and at the substrate. We rigorously clarify how the elastic energy enters the evolution equation for the film thickness in order to provide a solid basis for further investigation: several conflicting models exist in the literature that predict qualitatively different behaviour. We consolidate the various approaches and show that the long-wave model derived through an asymptotic expansion of the full nemato-hydrodynamic equations with consistent boundary conditions agrees with the model one obtains by employing a thermodynamically motivated gradient dynamics formulation based on an underlying free energy functional. As a result, we find that in the case of strong anchoring the elastic distortion energy is always stabilising. To support the discussion in the main part of the paper, an appendix gives the full derivation of the evolution equation for the film thickness via asymptotic expansion. © 2013 AIP Publishing LLC.

  7. Yeast arming systems: pros and cons of different protein anchors and other elements required for display.

    Science.gov (United States)

    Andreu, Cecilia; Del Olmo, Marcel Lí

    2018-03-01

    Yeast display is a powerful strategy that consists in exposing peptides or proteins of interest on the cell surface of this microorganism. Ever since initial experiments with this methodology were carried out, its scope has extended and many applications have been successfully developed in different science and technology fields. Several yeast display systems have been designed, which all involve introducting into yeast cells the gene fusions that contain the coding regions of a signal peptide, an anchor protein, to properly attach the target to the cell surface, and the protein of interest to be exposed, all of which are controlled by a strong promoter. In this work, we report the description of such elements for the alternative systems introduced by focusing particularly on anchor proteins. The comparisons made between them are included whenever possible, and the main advantages and inconveniences of each one are discussed. Despite the huge number of publications on yeast surface display and the revisions published to date, this topic has not yet been widely considered. Finally, given the growing interest in developing systems for non-Saccharomyces yeasts, the main strategies reported for some are also summarized.

  8. New functional insights into the internal architecture of the laminated anchor spicules of Euplectella aspergillum.

    Science.gov (United States)

    Monn, Michael A; Weaver, James C; Zhang, Tianyang; Aizenberg, Joanna; Kesari, Haneesh

    2015-04-21

    To adapt to a wide range of physically demanding environmental conditions, biological systems have evolved a diverse variety of robust skeletal architectures. One such example, Euplectella aspergillum, is a sediment-dwelling marine sponge that is anchored into the sea floor by a flexible holdfast apparatus consisting of thousands of anchor spicules (long, hair-like glassy fibers). Each spicule is covered with recurved barbs and has an internal architecture consisting of a solid core of silica surrounded by an assembly of coaxial silica cylinders, each of which is separated by a thin organic layer. The thickness of each silica cylinder progressively decreases from the spicule's core to its periphery, which we hypothesize is an adaptation for redistributing internal stresses, thus increasing the overall strength of each spicule. To evaluate this hypothesis, we created a spicule structural mechanics model, in which we fixed the radii of the silica cylinders such that the force transmitted from the surface barbs to the remainder of the skeletal system was maximized. Compared with measurements of these parameters in the native sponge spicules, our modeling results correlate remarkably well, highlighting the beneficial nature of this elastically heterogeneous lamellar design strategy. The structural principles obtained from this study thus provide potential design insights for the fabrication of high-strength beams for load-bearing applications through the modification of their internal architecture, rather than their external geometry.

  9. Retroperitoneal aortic hemorrhage caused by penetration of an endovascular stent-graft anchoring barb.

    Science.gov (United States)

    Twine, Christopher P; Winterbottom, Andrew; Shaida, Nadeem; Boyle, Jonathan R

    2013-08-01

    To report a rare case of acute intraoperative retroperitoneal hemorrhage secondary to aortic penetration by the suprarenal anchoring barb on a stent-graft. A 75-year-old patient on dual antiplatelet therapy for coronary stents and low-molecular-weight heparin for atrial thrombus underwent elective endovascular repair of a 6.7-cm infrarenal abdominal aortic aneurysm. A device with suprarenal fixation and metal anchoring barbs was implanted, and a molding balloon was used that at no time covered the proximal bare metal stents or barbs. In recovery, the patient became tachycardic and hypotensive. After resuscitation, imaging identified an anterior barb penetrating the aortic wall, causing the acute retroperitoneal hemorrhage. A decision to treat conservatively rather than resort to open surgery was difficult but ultimately influenced by the patients' high risk for open surgery. The patient was treated by aggressive reversal of heparin and platelet transfusion, and the bleed settled spontaneously. Major surgery and subsequent morbidity may be avoided by medical management of what would appear to be a surgical problem.

  10. The bone-anchored hearing aid (BAHA) in children with auricular malformations.

    Science.gov (United States)

    Granström, G; Tjellström, A

    1997-04-01

    A retrospective study was undertaken to evaluate the outcome of the use of the bone-anchored hearing aid (BAHA) in children. All patients included in the study had bilateral auricular malformations. Previous alternatives had been conventional hearing aids or surgical middle ear reconstruction. Thirty-seven patients under 16 years of age were studied. The most common syndrome in the group was Treacher Collins. Sixteen of the patients had earlier middle ear reconstruction, the results of which did not produce social hearing. Of 40 inserted fixtures to anchor the BAHA, three were lost during the follow-up period because of failed osseointegration. Skin reactions were graded according to a clinical scoring system and were determined to be comparable in number and severity to those of an adult population. All patients in the study considered the BAHA to be superior to earlier bone-conduction devices. It is concluded that the BAHA is an excellent alternative to bone-conduction devices in children with auricular malformations. Middle ear surgery can be postponed until adulthood or abandoned, especially in syndromic patients in whom it is known to be difficult and unpredictable.

  11. Image deblocking using joint Gaussian mixture model and anchored neighborhood regression priors

    Science.gov (United States)

    Fan, Meng; He, Xiaohai; Xiong, Shuhua; Qing, Linbo

    2017-07-01

    At low bit rates, Block based transform coding method uses large quantization step to quantize transform coefficients, which usually causes compression artifacts for images. Post-processing strategy is a promising solution which can greatly improve the visual quality of degraded images without change of existing codec. In this paper, we propose an image deblocking method for JPEG compressed images using joint Gaussian mixture model (GMM) and anchored neighborhood regression priors. The proposed method takes advantage of image priors to reduce blocking artifacts and achieve a better image quality simultaneously. First, we utilize GMM to reduce blocking artifacts. Based on the assumption that similar image patches can be derived from one certain Gaussian probability distribution, we formulate the image deblocking as an optimization problem by maximizing a posteriori function. Solving this problem ultimately boils down to the liner Wiener filtering. We then learn mapping functions offline based on the recent adjusted anchored neighborhood regression to enhance image details and edges. Extensive experimental results validate that our proposed method performs better both objectively and subjectively compared to some recently presented methods.

  12. Uncertainty assessment of a dike with an anchored sheet pile wall using FEM

    Directory of Open Access Journals (Sweden)

    Rippi Aikaterini

    2016-01-01

    Full Text Available The Dutch design codes for the dikes with retaining walls rely on Finite Element Analysis (FEM in combination with partial safety factors. However, this can lead to conservative designs. For this reason, in this study, a reliability analysis is carried out with FEM calculations aiming to demonstrate the feasibility of reliability analysis for a dike with an anchored sheet pile wall modelled in the 2D FEM, Plaxis. Sensitivity and reliability analyses were carried out and enabled by coupling the uncertainty package, OpenTURNS and Plaxis. The most relevant (ultimate limit states concern the anchor, the sheet pile wall, the soil body failure (global instability and finally the system. The case was used to investigate the applicability of the First Order Reliability Method (FORM and Directional Sampling (DS to analysing these limit states. The final goal is to estimate the probability of failure and identify the most important soil properties that affect the behaviour of each component and the system as a whole. The results of this research can be used to assess and optimize the current design procedure for dikes with retaining walls.

  13. Bone-anchored titanium implants for auricular rehabilitation: case report and review of literature.

    Science.gov (United States)

    Gumieiro, Emne Hammoud; Dib, Luciano Lauria; Jahn, Ricardo Schmitutz; Santos Junior, João Ferreira dos; Nannmark, Ulf; Granström, Gösta; Abrahão, Márcio

    2009-01-01

    Osseointegrated implants have acquired an important role in the prosthetic rehabilitation of patients with craniofacial defects. The main indications are lack of local tissue for autogenous reconstruction, previous reconstruction failure and selection of this technique by the patient. This paper presents a clinical case and discusses indications and advantages of the osseointegrated implant technique for retention of auricular prostheses. Case report, Universidade Federal de São Paulo (UNIFESP). A female patient received three auricular implants after surgical resection of a hemangioma in her left ear. The time taken for osseointegration of the temporal bone was three months. After fabrication of the implant-retained auricular prosthesis, the patient was monitored for 12 months. The clinical parameters evaluated showed good postoperative healing, healthy peri-implant tissue, good hygiene and no loss of implants. Good hygiene combined with thin and immobile peri-implant soft tissues resulted in minimal complications. Craniofacial implant integration appears to be site-dependent; increasing age affects osseointegration in the temporal bone. The frequency of adverse skin reactions in peri-implant tissues is generally low. The surgical technique for rehabilitation using implant-retained auricular prostheses seems to be simple. It is associated with low rates of adverse skin reactions and long-term complications. Prostheses anchored by osseointegrated implants seem to provide better retention than do prostheses supported on spectacle frames, less risk of discoloration through the use of adhesives and better esthetic results than do prostheses anchored in the surgical cavity.

  14. Novel telomere-anchored PCR approach for studying sexual stage telomeres in Aspergillus nidulans.

    Directory of Open Access Journals (Sweden)

    Nengding Wang

    Full Text Available Telomere length varies between germline and somatic cells of the same organism, leading to the hypothesis that telomeres are lengthened during meiosis. However, little is known about the meiotic telomere length in many organisms. In the filamentous fungus Aspergillus nidulans, the telomere lengths in hyphae and asexual spores are invariant. No study using existing techniques has determined the telomere length of the sexual ascospores due to the relatively low abundance of pure meiotic cells in A. nidulans and the small quantity of DNA present. To address this, we developed a simple and sensitive PCR strategy to measure the telomere length of A. nidulans meiotic cells. This novel technique, termed "telomere-anchored PCR," measures the length of the telomere on chromosome II-L using a small fraction of the DNA required for the traditional terminal restriction fragment (TRF Southern analysis. Using this approach, we determined that the A. nidulans ascospore telomere length is virtually identical to telomeres of other cell types from this organism, approximately 110 bp, indicating that a surprisingly strict telomere length regulation exists in the major cell types of A. nidulans. When the hyphal telomeres were measured in a telomerase reverse transcriptase (TERT knockout strain, small decreases in length were readily detected. Thus, this technique can detect telomeres in relatively rare cell types and is particularly sensitive in measuring exceptionally short telomeres. This rapid and inexpensive telomere-anchored PCR method potentially can be utilized in other filamentous fungi and types of organisms.

  15. Rigid Nylon Foil-Anchored Polytetrafluoroetyhlene (Gor-Tex) Sheet Stenting For Conjunctival Fornix Reconstruction

    Science.gov (United States)

    Demirci, Hakan; Elner, Susan G.; Elner, Victor M.

    2011-01-01

    Purpose To describe a surgical technique that deepens foreshortened conjunctival fornices by providing a scaffold for epithelialization that opposes contractile forces during wound healing. Design Retrospective interventional case series Participants Seventeen patients with anophthalmic sockets containing foreshortened conjunctival fornices Methods Conjunctival fornices was reconstructed with stents of expanded polytetrafluoroethylene (e-PTFE) sheet draped over rigid, 0.8 mm thick nylon strips that were anchored to the orbital rim. Preoperative and postoperativesymptoms, prosthesis retention, fornix depth, and lagophthalmos were assessed. Main Outcome Measure Prosthesis retention, fornix depth, and lagophthalmos Results All 17 patients had preoperative inability to retain their prosthesis. After postoperative follow-up of 47 ± 43 months, retention was improved in all patients and was entirely satisfactory in 15 (88%) patients. After reconstruction, the repaired fornix was deep in 7 (41%) patients, adequate to retain a prosthesis in 9 (53%) patients, and shallow in 1 (6%) patient. Lagophthalmos improved in 15 (88%) patients and remained unchanged in 2 (12%) patients. Superior fornix was reconstructed concurrently with the inferior fornix in 6 patients. In these patients, the superior fornix improved to deep (3 patients; 50%) or adequate (2; 33%). In 1 (17%) patient, it remained shallow. Conclusion Rigid, nylon-foil anchored e-PTFE stenting opposes postoperative contracture, improving prosthesis retention, and lagophthalmos. It does not require an additional surgical site for graft harvesting. PMID:20691479

  16. Synthesis in situ of gold nanoparticles by a dialkynyl Fischer carbene complex anchored to glass surfaces

    International Nuclear Information System (INIS)

    Bertolino, María Candelaria; Granados, Alejandro Manuel

    2016-01-01

    Highlights: • Fischer carbene 1-W reacts via cycloaddition without Cu(I) with azide terminal surface. • This reaction on the surface is regioselective to internal triple bond of 1-W. • 1-W bound to glass surface produce AuNps in situ fixed to the surface. • This ability is independent of how 1-W is bonded to the surface. • This hybrid surface can be valuable as SERS substrate or in heterogeneous catalysis. - Abstract: In this work we present a detailed study of classic reactions such as “click reaction” and nucleophilic substitution reaction but on glass solid surface (slides). We used different reactive center of a dialkynylalcoxy Fischer carbene complex of tungsten(0) to be anchored to modified glass surface with amine, to obtain aminocarbene, and azide terminal groups. These cycloaddition reaction showed regioselectivity to internal triple bond of dialkynyl Fischer carbene complex without Cu(I) as catalyst. Anyway the carbene anchored was able to act as a reducing agent to produce in situ very stable gold nanoparticles fixed on surface. We showed the characterization of modified glasses by contact angle measurements and XPS. Synthesized nanoparticles were characterized by SEM, XPS, EDS and UV–vis. The modified glasses showed an important enhancement Raman-SERS. This simple, fast and robust method to create a polifunctional and hybrid surfaces can be valuable in a wide range of applications such as Raman-SERS substrates and other optical fields.

  17. Shear Rehabilitation of RC Deep Beams using NSM CFRP Anchor Bars

    Directory of Open Access Journals (Sweden)

    Abdul Samad Abdul Aziz

    2017-01-01

    Full Text Available This paper presents results of an experimental study for the shear strengthening of reinforced concrete (RC deep beam using near surface mounted (NSM carbon fiber reinforced polymer (CFRP anchor bars. To ensure shear failure, five RC deep beam specimens were cast with nominal shear reinforcement. Shear strengthening of the RC deep beams was conducted by inserting 5 mm diameter by 450 mm length of CFRP bars as anchors with spacing of 100 mm and 150 mm centre to centre from the support of the beam. All RC beams were simply supported and subjected to a four-point bending test with shear span to effective depth ratio of 0.864. The results presented include the ultimate load, CFRP contribution to shear, modes of failure and the load-deflection profile. The shear enhancement of the RC deep beams shows an increment of 17.3% up to 25.5% with decreasing mid-span deflection from 6.4% to 15.1%. In addition, using this technique also increases its flexural beam resistance under the same conditions.

  18. Covalent Anchoring of Chloroperoxidase and Glucose Oxidase on the Mesoporous Molecular Sieve SBA-15

    Directory of Open Access Journals (Sweden)

    Martin Hartmann

    2010-02-01

    Full Text Available Functionalization of porous solids plays an important role in many areas, including heterogeneous catalysis and enzyme immobilization. In this study, large-pore ordered mesoporous SBA-15 molecular sieves were synthesized with tetraethyl orthosilicate (TEOS in the presence of the non-ionic triblock co-polymer Pluronic P123 under acidic conditions. These materials were grafted with 3 aminopropyltrimethoxysilane (ATS, 3-glycidoxypropyltrimethoxysilane (GTS and with 3 aminopropyltrimethoxysilane and glutaraldehyde (GA-ATS in order to provide covalent anchoring points for enzymes. The samples were characterized by nitrogen adsorption, powder X-ray diffraction, solid-state NMR spectroscopy, elemental analysis, diffuse reflectance fourier transform infrared spectroscopy and diffuse reflectance UV/Vis spectroscopy. The obtained grafted materials were then used for the immobilization of chloroperoxidase (CPO and glucose oxidase (GOx and the resulting biocatalysts were tested in the oxidation of indole. It is found that enzymes anchored to the mesoporous host by the organic moieties can be stored for weeks without losing their activity. Furthermore, the covalently linked enzymes are shown to be less prone to leaching than the physically adsorbed enzymes, as tested in a fixed-bed reactor under continuous operation conditions.

  19. Rh Nanoparticle Anchoring on Metal Phosphates: Fundamental Aspects and Practical Impacts on Catalysis.

    Science.gov (United States)

    Machida, Masato

    2016-10-01

    Metal phosphates stabilize Rh nanoparticles on their surface via Rh-O-P bonds, in contrast to the Rh-O-M bonds formed on metal oxides (MO x ). The local structure, electronic structure, and redox properties of Rh nanoparticles anchored on metal phosphates, and their practical impacts on catalysis, are reviewed based on recent publications from the author's research group. Because of the covalency of the Rh-O-P bond, Rh oxide is readily reduced to metallic Rh having a higher catalytic activity, whereas Rh oxide on metal oxide supports is more difficult to reduce with an increase of the anchoring strength. Furthermore, Rh metal shows a higher tolerance to reoxidation when supported on metal phosphates because the Rh-O-P bond is preserved under reducing atmospheres. The electron deficiency of Rh metal is another feature that affects its catalytic properties, and the extent of the electron deficiency can be tuned by replacing the metal in the metal phosphate with one of higher basicity. Further impacts on practical performance (thermal stability, poisoning stability, and lean NO x purification) in automobile catalyst applications are also described. © 2016 The Chemical Society of Japan & Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  20. Germ Plasm Anchoring Is a Dynamic State that Requires Persistent Trafficking

    Directory of Open Access Journals (Sweden)

    Kristina S. Sinsimer

    2013-12-01

    Full Text Available Localized cytoplasmic determinants packaged as ribonucleoprotein (RNP particles direct embryonic patterning and cell fate specification in a wide range of organisms. Once established, the asymmetric distributions of such RNP particles must be maintained, often over considerable developmental time. A striking example is the Drosophila germ plasm, which contains RNP particles whose localization to the posterior of the egg during oogenesis results in their asymmetric inheritance and segregation of germline from somatic fates in the embryo. Although actin-based anchoring mechanisms have been implicated, high-resolution live imaging revealed persistent trafficking of germ plasm RNP particles at the posterior cortex of the Drosophila oocyte. This motility relies on cortical microtubules, is mediated by kinesin and dynein motors, and requires coordination between the microtubule and actin cytoskeletons. Finally, we show that RNP particle motility is required for long-term germ plasm retention. We propose that anchoring is a dynamic state that renders asymmetries robust to developmental time and environmental perturbations.

  1. Hydrous ruthenium oxide nanoparticles anchored to graphene and carbon nanotube hybrid foam for supercapacitors

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Wei [Univ. of California, Riverside, CA (United States); Guo, S. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Lee, I. [Univ. of California, Riverside, CA (United States); Ahmed, K. [Univ. of California, Riverside, CA (United States); Zhong, J. [Univ. of California, Riverside, CA (United States); Favors, Z. [Univ. of California, Riverside, CA (United States); Zaera, F. [Univ. of California, Riverside, CA (United States); Ozkan, M. [Univ. of California, Riverside, CA (United States); Ozkan, C. S [Univ. of California, Riverside, CA (United States)

    2014-03-25

    In real life applications, supercapacitors (SCs) often can only be used as part of a hybrid system together with other high energy storage devices due to their relatively lower energy density in comparison to other types of energy storage devices such as batteries and fuel cells. Increasing the energy density of SCs will have a huge impact on the development of future energy storage devices by broadening the area of application for SCs. Here, we report a simple and scalable way of preparing a three-dimensional (3D) sub-5 nm hydrous ruthenium oxide (RuO₂) anchored graphene and CNT hybrid foam (RGM) architecture for high-performance supercapacitor electrodes. This RGM architecture demonstrates a novel graphene foam conformally covered with hybrid networks of RuO₂ nanoparticles and anchored CNTs. SCs based on RGM show superior gravimetric and per-area capacitive performance (specific capacitance: 502.78 F g⁻¹, areal capacitance: 1.11 F cm⁻²) which leads to an exceptionally high energy density of 39.28 Wh kg⁻¹ and power density of 128.01 kW kg⁻¹. The electrochemical stability, excellent capacitive performance, and the ease of preparation suggest this RGM system is promising for future energy storage applications.

  2. Electro-osmosis of nematic liquid crystals under weak anchoring and second-order surface effects

    Science.gov (United States)

    Poddar, Antarip; Dhar, Jayabrata; Chakraborty, Suman

    2017-07-01

    Advent of nematic liquid crystal flows has attracted renewed attention in view of microfluidic transport phenomena. Among various transport processes, electro-osmosis stands as one of the efficient flow actuation mechanisms through narrow confinements. In the present study, we explore the electrically actuated flow of an ordered nematic fluid with ionic inclusions, taking into account the influences from surface-induced elasticity and electrical double layer (EDL) phenomena. Toward this, we devise the coupled flow governing equations from fundamental free-energy analysis, considering the contributions from first- and second-order elastic, dielectric, flexoelectric, charged surface polarization, ionic and entropic energies. The present study focuses on the influence of surface charge and elasticity effects in the resulting linear electro-osmosis through a slit-type microchannel whose surfaces are chemically treated to display a homeotropic-type weak anchoring state. An optical periodic stripe configuration of the nematic director has been observed, especially for higher electric fields, wherein the Ericksen number for the dynamic study is restricted to the order of unity. Contrary to the isotropic electrolytes, the EDL potential in this case was found to be dependent on the external field strength. Through a systematic investigation, we brought out the fact that the wavelength of the oscillating patterns is dictated mainly by the external field, while the amplitude depends on most of the physical variables ranging from the anchoring strength and the flexoelectric coefficients to the surface charge density and electrical double layer thickness.

  3. PSA-2, Stress Analysis, Thermal Expansion and Loads in Multi Anchor Piping System

    International Nuclear Information System (INIS)

    Nickols, A.N.

    1975-01-01

    1 - Description of problem or function: PSA2 computes the reactions and stresses caused by thermal expansion and loads in a multi-anchor piping system which may contain loops and may be partially restrained at any point in any direction. 2 - Method of solution: The linear equations for the statically indeterminate pipe system are set up by a generalization of Brock's matrix method. By a systematic use of linear transforms, the matrix of the system of linear equations can be obtained by incidence algebra in the form of a symmetric banded matrix. 2 - Restrictions on the complexity of the problem - Maximum of: 36 sections. 3 - Unusual features of the program - PSA2 takes into account: (a) elasticity of the attachment of the pipe to the foundation, (b) restraints on pipe displacements by anchors and intermediate partial constraints of linear type, (c) given constant forces and moments acting upon the pipe system, (d) thermal expansion, (e) any geometrical structure of the pipe system, (f) several cases of stressing per pipe system, and (g) both metric and English units

  4. Cytogenetical anchoring of sheep linkage map and syntenic groups using a sheep BAC library

    Directory of Open Access Journals (Sweden)

    Cribiu Edmond-Paul

    2000-07-01

    Full Text Available Abstract In order to simultaneously integrate linkage and syntenic groups to the ovine chromosomal map, a sheep bacterial artificial chromosome (BAC library was screened with previously assigned microsatellites using a sheep-hamster hybrid panel and genetic linkage. Thirty-three BACs were obtained, fluorescently labelled and hybridised on sheep-goat hybrid metaphases (2n = 57. This study allowed us, (i, to anchor all linkage groups on sheep chromosomes, (ii, to give information on the probable position of the centromere on the linkage map for the centromeric chromosomes, (iii, to contradict the previous orientation of the ovine × linkage group by the mapping of BMS1008 on OARXq38. Concerning our somatic cell hybrid panel, this study resulted in the assignment of all the previously unassigned groups to ovine chromosomes and a complete characterisation of the hybrid panel. In addition, since hybridisations were performed on a sheep-goat hybrid, new marker/anchoring points were added to the caprine cytogenetic map.

  5. Conceptual design of cooling anchor for current lead on HTS field coils

    Energy Technology Data Exchange (ETDEWEB)

    Hyeon, C. J.; Kim, J. H.; Quach, H. L. [Dept. of Electrical Engineering, Jeju National University, Jeju (Korea, Republic of); and others

    2017-06-15

    The role of current lead in high-temperature superconducting synchronous machine (HTSSM) is to function as a power supply by connecting the power supply unit at room temperature with the HTS field coils at cryogenic temperature. Such physical and electrical connection causes conduction and Joule-heating losses, which are major thermal losses of HTSSM rotors. To ensure definite stability and economic feasibility of HTS field coils, quickly and smoothly cooling down the current lead is a key design technology. Therefore, in this paper, we introduce a novel concept of a cooling anchor to enhance the cooling performance of a metal current lead. The technical concept of this technology is the simultaneously chilling and supporting the current lead. First, the structure of the current lead and cooling anchor were conceptually designed for field coils for a 1.5 MW-class HTSSM. Then, the effect of this installation on the thermal characteristics of HTS coils was investigated by 3D finite element analysis.

  6. Age and Sex Effects in Anchoring Vignette Studies: Methodological and Empirical Contributions

    Directory of Open Access Journals (Sweden)

    Hanna Grol-Prokopczyk

    2013-04-01

    Full Text Available Anchoring vignettes are an increasingly popular tool for identifying and correcting for group differences in use of subjective ordered response categories. However, existing techniques to maximize response consistency (use of the same standards for self-ratings as for vignette-ratings, which center on matching vignette characters’ demographic characteristics to respondents’ own characteristics, appear at times to be ineffective or to pose interpretive difficulties. Specifically, respondents often appear to neglect instructions to treat vignette characters as age peers. Furthermore, when vignette characters’ sex is matched to respondents’ sex, interpretation of sex differences in rating style is rendered problematic. This study applies two experimental manipulations to a national American sample (n=1,765 to clarify best practices for enhancing response consistency. First, an analysis of two methods of highlighting vignette characters’ age suggests that both yield better response consistency than previous, less prominent means. Second, a comparison of ratings of same- and opposite-sex vignette characters suggests that, with avoidable exceptions, the sex of the respondent rather than of the vignette character drives observed sex differences in rating style. Implications for interpretation and design of anchoring vignette studies are discussed. Findings also show significant sex, educational, and racial/ethnic differences in styles of rating health, and racial/ethnic differences in styles of rating political efficacy. These findings underscore the incomparability of unadjusted subjective self-ratings across demographic groups.

  7. Bone-anchored hearing aid implant location in relation to skin reactions.

    Science.gov (United States)

    Faber, Hubert T; de Wolf, Maarten J F; de Rooy, Jacky W J; Hol, Myrthe K S; Cremers, Cor W R J; Mylanus, Emmanuel A M

    2009-08-01

    To evaluate the effect of implant location and skin thickness on the frequency and degree of adverse skin reactions around the abutment. Retrospective multivariate analysis of implant position related to skin thickness and clinical variables. Tertiary referral center. Random sample of 248 patients with bone-anchored hearing aids. Bone-anchored hearing aid implant placement by means of the linear incision technique. Type and number of skin reactions and implant loss. The mean (SD) distance from the external auditory ear canal to implant was 48.8 (8.0) mm (range, 29-84 mm). The mean skin thickness was 5.5 (1.9) mm. Severe skin reactions (Holgers classification, 2-4) were seen in 46 of the 248 patients (18.5%). Implant loss occurred in 4 patients (1.6%). Three implants were lost owing to failed osseointegration (1.3%), and another implant was removed because of deterioration of cochlear function (0.9%). No implant was lost as a result of infection. Implant location and skin thickness were not correlated with implant loss or the frequency or degree of adverse skin reactions around the abutment.

  8. A minimally invasive technique for the implantation of bone-anchored hearing devices.

    Science.gov (United States)

    Wilson, David F; Kim, Harold H

    2013-09-01

    To describe and evaluate a novel technique for the implantation of bone conduction hearing devices as compared with a common, conventional technique. Case series with chart review. Tertiary referral otology and neurotology practice. Individuals who underwent the implantation of bone-anchored hearing devices between January 1, 2004, and December 31, 2011, were identified. Demographic data, surgical indications, surgical technique used, surgical time, and complications were recorded. Soft tissue complications were graded on the Holgers classification scheme. Group 1 was defined as those undergoing a traditional technique using a dermatome with subcutaneous tissue reduction. Group 2 was defined as those undergoing the described technique for implantation of the coupling hardware with minimal subcutaneous soft tissue reduction. Forty patients underwent the procedure, with 11 patients comprising group 1 and 29 patients comprising group 2. Group 2 required a shorter operative time (32.3 vs 56.1 minutes, P bone-anchored hearing devices using the described technique that necessitated minimal soft tissue reduction.

  9. Abutment-free bone-anchored hearing devices in children: initial results and experience.

    Science.gov (United States)

    Centric, Aaron; Chennupati, Sri Kiran

    2014-05-01

    Bone-anchored implantable hearing devices are widely accepted as a surgical option for certain types of hearing loss in both adults and children. Most commercially available devices involve a percutaneous abutment to which a sound processor attaches. The rate of complications with such bone conduction systems is greater than 20%. Most complications arise from the abutment. Recently, the Sophono (Boulder, CO) Alpha 1, an abutment-free system, has been introduced. We conducted a retrospective chart review of the first five patients who underwent implantation with the Sophono abutment-free bone conduction hearing system with the Alpha 1 processor at our institution and report here on these patients' pre- and postoperative audiometric data and clinical courses. Average improvement in pure-tone average was 32dB hearing loss and average improvement in speech response threshold was 28dB hearing loss. All patients were responding in the normal to mild hearing loss range in the operated ear after device activation. Average improvement across individual frequencies was between 17 and 37dB (SD 5.5-11dB). Our audiometric results to date are promising and have been consistent with published data on other bone-anchored hearing devices. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  10. Multivalent anchoring and cross-linking of mussel-inspired antifouling surface coatings.

    Science.gov (United States)

    Wei, Qiang; Becherer, Tobias; Mutihac, Radu-Cristian; Noeske, Paul-Ludwig Michael; Paulus, Florian; Haag, Rainer; Grunwald, Ingo

    2014-08-11

    In this work, we combine nature's amazing bioadhesive catechol with the excellent bioinert synthetic macromolecule hyperbranched polyglycerol (hPG) to prepare antifouling surfaces. hPG can be functionalized by different amounts of catechol groups for multivalent anchoring and cross-linking because of its highly branched architecture. The catecholic hPGs can be immobilized on various surfaces including metal oxides, noble metals, ceramics, and polymers via simple incubation procedures. The effect of the catechol amount on the immobilization, surface morphology, stability, and antifouling performance of the coatings was studied. Both anchoring and cross-linking interactions provided by catechols can enhance the stability of the coatings. When the catechol groups on the hPG are underrepresented, the tethering of the coating is not effective; while an overrepresentation of catechol groups leads to protein adsorption and cell adhesion. Thus, only a well-balanced amount of catechols as optimized and described in this work can supply the coatings with both good stability and antifouling ability.

  11. Synthesis in situ of gold nanoparticles by a dialkynyl Fischer carbene complex anchored to glass surfaces

    Science.gov (United States)

    Bertolino, María Candelaria; Granados, Alejandro Manuel

    2016-10-01

    In this work we present a detailed study of classic reactions such as ;click reaction; and nucleophilic substitution reaction but on glass solid surface (slides). We used different reactive center of a dialkynylalcoxy Fischer carbene complex of tungsten(0) to be anchored to modified glass surface with amine, to obtain aminocarbene, and azide terminal groups. These cycloaddition reaction showed regioselectivity to internal triple bond of dialkynyl Fischer carbene complex without Cu(I) as catalyst. Anyway the carbene anchored was able to act as a reducing agent to produce in situ very stable gold nanoparticles fixed on surface. We showed the characterization of modified glasses by contact angle measurements and XPS. Synthesized nanoparticles were characterized by SEM, XPS, EDS and UV-vis. The modified glasses showed an important enhancement Raman-SERS. This simple, fast and robust method to create a polifunctional and hybrid surfaces can be valuable in a wide range of applications such as Raman-SERS substrates and other optical fields.

  12. Development of myotendinous-like junctions that anchor cardiac valves requires fibromodulin and lumican.

    Science.gov (United States)

    Dupuis, Loren E; Doucette, Lorna; Rice, A Kittrell; Lancaster, Ashton E; Berger, Matthew G; Chakravarti, Shukti; Kern, Christine B

    2016-10-01

    There are many patients that exhibit connective tissue related cardiac malformations but do not have mutations in collagen genes. The Small Leucine Rich Proteoglycans (SLRP) fibromodulin (FMOD) and lumican (LUM) bind collagen and regulate fibril assembly in other biological contexts. FMOD deficient mice and double deficient FMOD; LUM mice exhibited anomalies in regions where cardiac valve tissue interdigitates with adjacent muscle for support. Ectopic connective and/or myocardial tissue(s) was associated with the more severe cardiac valve anomalies in FMOD; LUM deficient mice. At postnatal day 0 (P0) there was an increase in the mesenchymal cell number in the regions where valve cusps anchor in FMOD; LUM deficient mice compared to WT. The cardiac valve anomalies correlated with the highest levels of FMOD expression in the heart and also where myotendinous junctions (MTJ) components biglycan, collagen type I alpha 1, and collagen type VI, are also localized. The postnatal assembly of the collagen-rich ECM in regions where cardiac valves anchor, that we have designated 'myotendinous-like junctions' (MTLJ) requires the SLRPs FMOD and LUM. Moreover, FMOD and LUM may facilitate mesenchymal cell differentiation in late stages of cardiac valve development. Developmental Dynamics 245:1029-1042, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  13. MARCH6 and TRC8 facilitate the quality control of cytosolic and tail-anchored proteins.

    Science.gov (United States)

    Stefanovic-Barrett, Sandra; Dickson, Anna S; Burr, Stephen P; Williamson, James C; Lobb, Ian T; van den Boomen, Dick Jh; Lehner, Paul J; Nathan, James A

    2018-03-08

    Misfolded or damaged proteins are typically targeted for destruction by proteasome-mediated degradation, but the mammalian ubiquitin machinery involved is incompletely understood. Here, using forward genetic screens in human cells, we find that the proteasome-mediated degradation of the soluble misfolded reporter, mCherry-CL1, involves two ER-resident E3 ligases, MARCH6 and TRC8. mCherry-CL1 degradation is routed via the ER membrane and dependent on the hydrophobicity of the substrate, with complete stabilisation only observed in double knockout MARCH6/TRC8 cells. To identify a more physiological correlate, we used quantitative mass spectrometry and found that TRC8 and MARCH6 depletion altered the turnover of the tail-anchored protein heme oxygenase-1 (HO-1). These E3 ligases associate with the intramembrane cleaving signal peptide peptidase (SPP) and facilitate the degradation of HO-1 following intramembrane proteolysis. Our results highlight how ER-resident ligases may target the same substrates, but work independently of each other, to optimise the protein quality control of selected soluble and tail-anchored proteins. © 2018 The Authors. Published under the terms of the CC BY 4.0 license.

  14. Early infancy-onset stimulation-induced myoclonic seizures in three siblings with inherited glycosylphosphatidylinositol (GPI) anchor deficiency.

    Science.gov (United States)

    Mogami, Yukiko; Suzuki, Yasuhiro; Murakami, Yoshiko; Ikeda, Tae; Kimura, Sadami; Yanagihara, Keiko; Okamoto, Nobuhiko; Kinoshita, Taroh

    2018-02-01

    Inherited glycosylphosphatidylinositol anchor deficiency causes a variety of clinical symptoms, including epilepsy, however, little information is available regarding seizures as a symptom. We report three siblings with inherited glycosylphosphatidylinositol anchor deficiency with PIGL gene mutations. The phenotypes of the subjects were not consistent with CHIME syndrome or Mabry syndrome, as reported in previous studies. All shared some clinical manifestations, including transient apnoea as neonates, dysmorphic facial features, and intellectual disability. Between one week and 3 months of life, all patients developed myoclonic seizures. Myoclonic jerks were easily evoked by sudden unexpected acoustic or tactile stimuli. None showed elevation of serum alkaline phosphatase. Vitamin B 6 was given to one of the three siblings, but failed to suppress seizures. The presence of early infancy-onset stimulation-induced myoclonic seizures combined with dysmorphic facial features should lead physicians to consider the possibility of inherited glycosylphosphatidylinositol anchor deficiency.

  15. Design of stable polyether-magnetite complexes in aqueous media: effects of the anchor group, molecular weight, and chain density.

    Science.gov (United States)

    Miles, William C; Huffstetler, Philip P; Goff, Jonathan D; Chen, Alfred Y; Riffle, J S; Davis, Richey M

    2011-05-03

    The colloidal stability of polymer-stabilized nanoparticles is critical for therapeutic use. However, phosphates in physiological media can induce polymer desorption and consequently flocculation. Colloidal characteristics of PEO-magnetite nanoparticles with different anchors for attaching PEO to magnetite were examined in PBS. The effects of the number of anchors, PEO molecular weight, and chain density were examined. It was observed that ammonium phosphonates anchored PEO to magnetite effectively in phosphate-containing solutions because of interactions between the phosphonates and magnetite. Additionally, a method to estimate the magnetite surface coverage was developed and was found to be critical to the prediction of colloidal stability. This is key to understanding how functionalized surfaces interact with their environment.

  16. Streptolysin-O induces release of glycosylphosphatidylinositol-anchored alkaline phosphatase from ROS cells by vesiculation independently of phospholipase action.

    Science.gov (United States)

    Xie, M; Low, M G

    1995-01-01

    Streptolysin-O (SLO), a cholesterol-binding agent, was used for studies on the release of glycosylphosphatidylinositol (GPI)-anchored alkaline phosphatase (AP) from ROS cells. Treatment of cells with SLO resulted in a time- and concentration-dependent release of AP into the extracellular medium. This release was potentiated by Ca2+ and bovine serum, but not by GPI-specific phospholipase D (GPI-PLD) purified from bovine serum. The released AP distributed to the detergent phase after Triton X-114 phase separation. This result suggested that the released AP contained an intact GPI anchor, and thus both proteolysis and anchor degradation by anchor-specific hydrolases, including GPI-PLD, as the potential mechanisms for SLO-mediated AP release were ruled out. The released AP sedimented at 100,000 g. A substantial amount of lipids was detected in the 100,000 g pellet. Cholesterol and sphingomyelin were enriched in SLO-released material, compared with intact cells. These results were consistent with vesiculation as the mechanism for SLO induction of AP release. Two other cholesterol-binding agents, saponin and digitonin, were also able to release AP, possibly by a similar vesiculation mechanism, whereas others, including nystatin, filipin and beta-escin, failed to elicit any AP release. Eight GPI-anchored proteins were identified in ROS cells, and all were substantially enriched in the vesicles released by SLO. Taken together, these results do not provide any support for the hypothesis that the clustering of GPI-anchored proteins in the plasma membrane is responsible for their resistance to GPI-PLD cleavage. Images Figure 5 Figure 6 PMID:7832771

  17. Transcript expression analysis of putative Trypanosoma brucei GPI-anchored surface proteins during development in the tsetse and mammalian hosts.

    Directory of Open Access Journals (Sweden)

    Amy F Savage

    Full Text Available Human African Trypanosomiasis is a devastating disease caused by the parasite Trypanosoma brucei. Trypanosomes live extracellularly in both the tsetse fly and the mammal. Trypanosome surface proteins can directly interact with the host environment, allowing parasites to effectively establish and maintain infections. Glycosylphosphatidylinositol (GPI anchoring is a common posttranslational modification associated with eukaryotic surface proteins. In T. brucei, three GPI-anchored major surface proteins have been identified: variant surface glycoproteins (VSGs, procyclic acidic repetitive protein (PARP or procyclins, and brucei alanine rich proteins (BARP. The objective of this study was to select genes encoding predicted GPI-anchored proteins with unknown function(s from the T. brucei genome and characterize the expression profile of a subset during cyclical development in the tsetse and mammalian hosts. An initial in silico screen of putative T. brucei proteins by Big PI algorithm identified 163 predicted GPI-anchored proteins, 106 of which had no known functions. Application of a second GPI-anchor prediction algorithm (FragAnchor, signal peptide and trans-membrane domain prediction software resulted in the identification of 25 putative hypothetical proteins. Eighty-one gene products with hypothetical functions were analyzed for stage-regulated expression using semi-quantitative RT-PCR. The expression of most of these genes were found to be upregulated in trypanosomes infecting tsetse salivary gland and proventriculus tissues, and 38% were specifically expressed only by parasites infecting salivary gland tissues. Transcripts for all of the genes specifically expressed in salivary glands were also detected in mammalian infective metacyclic trypomastigotes, suggesting a possible role for these putative proteins in invasion and/or establishment processes in the mammalian host. These results represent the first large-scale report of the differential

  18. Effect of historical earthquakes on pre-stressed anchor tie back diaphragm wall and on near-by building

    Directory of Open Access Journals (Sweden)

    Kamal Mohamed Hafez Ismail Ibrahim

    2013-04-01

    Full Text Available Pre-stressed tie back anchored diaphragm walls are considered one of the safest lateral supports which help in overall stability when there is a significant difference in land level between back and front of these walls. Permanent lateral supports to these walls are frequently represented by supporting it laterally with foundation and floor slabs of the building. In this paper a special study of one raw anchor diaphragm wall subjected to different earthquake dynamic loads will be presented. The wall retains an excavation of 9.5 m and supports laterally a near-by 5 floor building. Five historical strong motions with different fundamental frequencies are subjected on the wall. The wall displacement, straining actions, anchor extreme force and the influence of variation of anchor stiffness are calculated using a dynamic Plaxis finite element program. The soil is considered as elasto-plastic material and represented using Mohr–Coulomb criteria, the wall and the anchor are considered to behave elastically. Prescribed displacement at the lower bottom boundary represents the earthquake motion. Far left and right absorbent boundaries are assumed to prevent dynamic wave reflection. Four static phases representing construction procedure and one dynamic loading phase are considered. It is found that the straining actions of different historical earthquakes match in shape with each other, the only change is in the amplitude which is affected by earthquake fundamental frequency and its intensity. The maximum dynamic lateral displacement of the wall is at its free top. The near-by building shows a differential settlement towards the wall which causes a change in the sign and amplitude of the straining actions. Increasing the stiffness of anchor was also studied and it was found that it reduces too much the maximum dynamic top wall lateral displacement.

  19. Anatomic and Biomechanical Comparison of Traditional Bankart Repair With Bone Tunnels and Bankart Repair Utilizing Suture Anchors

    Science.gov (United States)

    Judson, Christopher H.; Charette, Ryan; Cavanaugh, Zachary; Shea, Kevin P.

    2016-01-01

    Background: Traditional Bankart repair using bone tunnels has a reported failure rate between 0% and 5% in long-term studies. Arthroscopic Bankart repair using suture anchors has become more popular; however, reported failure rates have been cited between 4% and 18%. There have been no satisfactory explanations for the differences in these outcomes. Hypothesis: Bone tunnels will provide increased coverage of the native labral footprint and demonstrate greater load to failure and stiffness and decreased cyclic displacement in biomechanical testing. Study Design: Controlled laboratory study. Methods: Twenty-two fresh-frozen cadaveric shoulders were used. For footprint analysis, the labral footprint area was marked and measured using a Microscribe technique in 6 specimens. A 3-suture anchor repair was performed, and the area of the uncovered footprint was measured. This was repeated with traditional bone tunnel repair. For the biomechanical analysis, 8 paired specimens were randomly assigned to bone tunnel or suture anchor repair with the contralateral specimen assigned to the other technique. Each specimen underwent cyclic loading (5-25 N, 1 Hz, 100 cycles) and load to failure (15 mm/min). Displacement was measured using a digitized video recording system. Results: Bankart repair with bone tunnels provided significantly more coverage of the native labral footprint than repair with suture anchors (100% vs 27%, P footprint anatomy while suture anchor repair covered less than 30% of the native footprint. Repair using bone tunnels resulted in significantly greater stiffness than repair with suture anchors. Load to failure and gap formation were not significantly different. PMID:26779555

  20. Avulsion Fracture of the Calcaneus Treated With a Soft Anchor Bridge and Lag Screw Technique: A Report of Two Cases.

    Science.gov (United States)

    Yoshida, Kazushige; Kasama, Kentaro; Akahane, Tsutomu

    2016-01-01

    The displaced extra-articular avulsion fracture of the calcaneus has been classified as a Böhler type 1c calcaneal fracture, and most cases will require surgical repair. In the present report, we describe 2 patients in whom we performed the soft anchor bridge technique using single loaded suture anchors with lag screws for the repair of Böhler type 1c avulsion fractures of the calcaneus. In one of these patients, clinically relevant osteoporosis complicated the injury. In both cases, bone union was achieved, and by 1.5 months after surgery satisfactory recovery was observed. To our knowledge, the soft anchor bridge technique was first used for the treatment of rotator cuff tears, and the greatest merit of this technique is the ability to generate vertical compression force to the pulled out rotator cuff through the use of knotting sutures. In recent years, the soft anchor bridge technique using 4 suture anchors has also been used for fractures of the greater tuberosity of the humerus, an injury that poses operative difficulties similar to those encountered with an avulsion fracture of the calcaneus owing to the traction force of the rotator cuff and relative weakness of adjacent bone. The outcomes of our patients suggest that the soft anchor bridge technique combined with adjunct lag screws is useful in the fixation of avulsion fractures of the calcaneus. In addition, the result in the elderly patient indicates the possibility of using this technique for patients with osteoporosis. Copyright © 2016 American College of Foot and Ankle Surgeons. Published by Elsevier Inc. All rights reserved.

  1. ANTS-anchored Zn-Al-CO{sub 3}-LDH particles as fluorescent probe for sensing of folic acid

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Pengfei; Liu, Dan; Liu, Yanhuan [State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029 (China); Beijing Key Laboratory of Environmentally Harmful Chemical Analysis, Beijing University of Chemical Technology, Beijing 100029 (China); Li, Lei, E-mail: lilei@mail.buct.edu.cn [State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029 (China); Beijing Key Laboratory of Environmentally Harmful Chemical Analysis, Beijing University of Chemical Technology, Beijing 100029 (China)

    2016-09-15

    A novel fluorescent nanosensor for detecting folic acid (FA) in aqueous media has been developed based on 8-aminonaphthalene-1,3,6-trisulfonate (ANTS) anchored to the surface of Zn-Al-CO{sub 3}-layered double hydroxides (LDH) particles. The nanosensor showed high fluorescence intensity and good photostability due to a strong coordination interaction between surface Zn{sup 2+} ions of Zn-Al-CO{sub 3}-LDH and N atoms of ANTS, which were verified by result of X-ray photoelectron spectroscopy (XPS). ANTS-anchored on the surface of Zn-Al-CO{sub 3}-LDH restricted the intra-molecular rotation leading to ANTS-anchored J-type aggregation emission enhancement. ANTS-anchored Zn-Al-CO{sub 3}-LDH particles exhibited highly sensitive and selective response to FA over other common metal ions and saccharides present in biological fluids. The proposed mechanism was that oxygen atoms of -SO{sub 3} groups in ANTS-anchored on the surface of Zn-Al-CO{sub 3}-LDH were easily collided by FA molecules to form potential hydrogen bonds between ANTS-anchored and FA molecules, which could effectively quench the ANTS-anchored fluorescence. Under the simulated physiological conditions (pH of 7.4), the fluorescence quenching was fitted to Stern-Volmer equation with a linear response in the concentration range of 1 μM to 200 μM with a limit of detection of 0.1 μM. The results indicate that ANTS-anchored Zn-Al-CO{sub 3}-LDH particles can afford a very sensitive system for the sensing FA in aqueous solution. - Highlights: • A novel fluorescent nanosensor has been developed. • The sensor exhibited highly sensitive and selective response to FA. • The fluorescence quenching was fitted to Stern–Volmer equation. • The linear response range was 1–200 μM with a limit of detection of 0.1 μM.

  2. Control of Homeostatic Synaptic Plasticity by AKAP-Anchored Kinase and Phosphatase Regulation of Ca2+-Permeable AMPA Receptors.

    Science.gov (United States)

    Sanderson, Jennifer L; Scott, John D; Dell'Acqua, Mark L

    2018-02-13

    Neuronal information processing requires multiple forms of synaptic plasticity mediated by NMDA and AMPA-type glutamate receptors (NMDAR, AMPAR). These plasticity mechanisms include long-term potentiation (LTP) and depression (LTD), which are Hebbian, homosynaptic mechanisms locally regulating synaptic strength of specific inputs, and homeostatic synaptic scaling, which is a heterosynaptic mechanism globally regulating synaptic strength across all inputs. In many cases, LTP and homeostatic scaling regulate AMPAR subunit composition to increase synaptic strength via incorporation of Ca 2+ -permeable receptors (CP-AMPAR) containing GluA1, but lacking GluA2, subunits. Previous work by our group and others demonstrated that anchoring of the kinase PKA and the phosphatase calcineurin (CaN) to A-kinase anchoring protein (AKAP) 150 play opposing roles in regulation of GluA1 Ser845 phosphorylation and CP-AMPAR synaptic incorporation during hippocampal LTP and LTD. Here, using both male and female knock-in mice that are deficient in PKA or CaN anchoring, we show that AKAP150-anchored PKA and CaN also play novel roles in controlling CP-AMPAR synaptic incorporation during homeostatic plasticity in hippocampal neurons. We found that genetic disruption of AKAP-PKA anchoring prevented increases in Ser845 phosphorylation and CP-AMPAR synaptic recruitment during rapid homeostatic synaptic scaling-up induced by combined blockade of action potential firing and NMDAR activity. In contrast, genetic disruption of AKAP-CaN anchoring resulted in basal increases in Ser845 phosphorylation and CP-AMPAR synaptic activity that blocked subsequent scaling-up by preventing additional CP-AMPAR recruitment. Thus, the balanced, opposing phospho-regulation provided by AKAP-anchored PKA and CaN is essential for control of both Hebbian and homeostatic plasticity mechanisms that require CP-AMPARs. Significance statement: Neuronal circuit function is shaped by multiple forms of activity

  3. ARTHROSCOPIC REPAIR OF BANKART’S LESION USING SUTURE ANCHORS IN RECURRENT ANTERIOR SHOULDER INSTABILITY

    Directory of Open Access Journals (Sweden)

    Santosh Kumar

    2015-06-01

    Full Text Available BACKGROUND : Shoulder instability and its treatment were described even in ancient times by the Greek and Egyptian physicians. Evidence of shoulder dislocation has been found in archaeological and paleopathological examinations of human shoulders several thousand years old. 1 Many techniques have been described in literature for treatment of recurrent shoulder dislocation. Arthroscopic repair of Bankart’s lesion using suture anchors is a noble technique. A suture anchor is a tiny screw with a thread attached to it. The screw is inserted into the bone over the glenoid rim while the sutures hold onto the labral tissue. These anchors provide a stable base for reattachment of the capsulolabral complex. We conducted a study on evaluation of long term effe ct of arthroscopic repair of Bankart’s lesion using suture anchors and compared our results with other studies published in literature . MATERIALS & METHODS : Since June 2012, arthroscopic Bankart’s repair using suture anchors was performed on 35 patients, who presented with recurrent anterior dislocation of shoulder. 34 man and 1 woman patients were included in the study. METHOD OF COLLECTION OF DATA: Adult patients with recurrent dislocations of shoulder with . INCLUSION CRITERIA: All patients > 15 years but =2 . EXCLUSION CRITERIA: Age group 60 years. Clinical evidence of multidirectional instability. Surgery of injured shou lder before 1 st episode of traumatic shoulder dislocation. Number o f dislocations <2 . Generalised ligamentous laxity. Presence of neuromuscular disorders. Presence of other comorbid conditions . Majority of patients were in the age group between 17 years to 49years, with mean age of 27.43 years. Most patients were young active individuals in the age group of 25 to 35 years. 20 patients (57% were involved in significant occupation requiring overhead activity such as students with sporting activities, agricul turists. 21(60% patients had their Right shoulder involved

  4. A second-generation anchored genetic linkage map of the tammar wallaby (Macropus eugenii

    Directory of Open Access Journals (Sweden)

    Patel Hardip R

    2011-08-01

    Full Text Available Abstract Background The tammar wallaby, Macropus eugenii, a small kangaroo used for decades for studies of reproduction and metabolism, is the model Australian marsupial for genome sequencing and genetic investigations. The production of a more comprehensive cytogenetically-anchored genetic linkage map will significantly contribute to the deciphering of the tammar wallaby genome. It has great value as a resource to identify novel genes and for comparative studies, and is vital for the ongoing genome sequence assembly and gene ordering in this species. Results A second-generation anchored tammar wallaby genetic linkage map has been constructed based on a total of 148 loci. The linkage map contains the original 64 loci included in the first-generation map, plus an additional 84 microsatellite loci that were chosen specifically to increase coverage and assist with the anchoring and orientation of linkage groups to chromosomes. These additional loci were derived from (a sequenced BAC clones that had been previously mapped to tammar wallaby chromosomes by fluorescence in situ hybridization (FISH, (b End sequence from BACs subsequently FISH-mapped to tammar wallaby chromosomes, and (c tammar wallaby genes orthologous to opossum genes predicted to fill gaps in the tammar wallaby linkage map as well as three X-linked markers from a published study. Based on these 148 loci, eight linkage groups were formed. These linkage groups were assigned (via FISH-mapped markers to all seven autosomes and the X chromosome. The sex-pooled map size is 1402.4 cM, which is estimated to provide 82.6% total coverage of the genome, with an average interval distance of 10.9 cM between adjacent markers. The overall ratio of female/male map length is 0.84, which is comparable to the ratio of 0.78 obtained for the first-generation map. Conclusions Construction of this second-generation genetic linkage map is a significant step towards complete coverage of the tammar wallaby

  5. Self-interacting polymer chains terminally anchored to adsorbing surfaces of three-dimensional fractal lattices

    Science.gov (United States)

    Živić, I.; Elezović-Hadžić, S.; Milošević, S.

    2018-01-01

    We have studied the adsorption problem of self-attracting linear polymers, modeled by self-avoiding walks (SAWs), situated on three-dimensional fractal structures, exemplified by 3d Sierpinski gasket (SG) family of fractals as containers of a poor solvent. Members of SG family are enumerated by an integer b (b ≥ 2), and it is assumed that one side of each SG fractal is an impenetrable adsorbing surface. We calculate the critical exponents γ1 ,γ11, and γs, which are related to the numbers of all possible SAWs with one, both, and no ends anchored to the adsorbing boundary, respectively. By applying the exact renormalization group (RG) method (for the first three members of the SG fractal family, b = 2 , 3, and 4), we have obtained specific values of these exponents, for θ-chain and globular polymer phase. We discuss their mutual relations and relations with corresponding values pertinent to extended polymer chain phase.

  6. Lithium isotope separation on an ion exchange resin having azacrown ether as an anchor group

    International Nuclear Information System (INIS)

    Kim, D.W.; Jeong, Y.K.; Lee, J.K.; Hong, Ch.P.; Kim, Ch.S.; Jeon, Y.Sh.

    1997-01-01

    As study on the separation of lithium isotopes was carried out with an ion exchange resin having 1,7,13-trioxa-4,10,16-triazacyclooctadecane (N 3 O 3 ) as an anchor group. The lighter isotope, 6 Li concentrated in the resin phase, while the heavier isotope, 7 Li is enriched in the fluid phase. Upon column chromatography [0.6 cm (I. D.) x 20 cm (height) using 1.0M ammonium chloride solution as an eluent, single separation factor, α, 1.068 ( 6 Li/ 7 Li) r esin/( 6 Li/ 7 Li) s olution was obtained by the GLUECKAUF method from the elution curve and isotope ratios. (author)

  7. Three year review following bone anchor repair of acute biceps tendon insertion rupture.

    Science.gov (United States)

    Hand, C J; Howell, G E

    2001-01-01

    Three patients with acute biceps brachii tendon insertion ruptures were treated (less than 7 days post injury) using bone anchor anatomical repair. Dynamometer assessment of strength in both limbs was performed after completion of rehabilitation and again at 3.3 years after surgery. All patients were male, age 34, 35 and 53 years. Early isokinetic assessment was performed at 6, 7 and 12 months post surgery and medium assessment at 3.3 years post surgery. A full range of movement was achieved at early assessment and maintained into medium term assessment. All patients returned to their full premorbid occupation and sporting activity. Dynamometer strength of a repaired dominant limb equated to two thirds of a normal non dominant limb at early assessment, equal power was found at medium term assessment and a measurable increase in strength in both affected and unaffected arms was seen.

  8. A Simplified Technique for Orientation of a Bone Anchored Auricular Prostheses: a Clinical Report

    Directory of Open Access Journals (Sweden)

    Hussein G. El Charkawi

    2012-08-01

    Full Text Available Background: A simple technique was presented in this clinical report for orientation of a bone anchored auricular prosthesis.Methods: The proposed technique includes drawing the intact ear on a transparent celluloid paper or radiographic film and flipping it to the opposite side and relating it to the fixed anatomical features on the face of patient.Results: The drawing, by this way provides a simple and easy way to duplicate and transfer the exact size and position of the intact ear to the defect side.Conclusions: This technique provides a simple, safe, inexpensive and time saving yet, an accurate and effective surgical template that orients the craniofacial implants to the confines of the definitive auricular prosthesis. It is indicated for restoration of single missing external ear either in aplasia, injuries and total resection.

  9. Anchoring quartet-based phylogenetic distances and applications to species tree reconstruction.

    Science.gov (United States)

    Sayyari, Erfan; Mirarab, Siavash

    2016-11-11

    Inferring species trees from gene trees using the coalescent-based summary methods has been the subject of much attention, yet new scalable and accurate methods are needed. We introduce DISTIQUE, a new statistically consistent summary method for inferring species trees from gene trees under the coalescent model. We generalize our results to arbitrary phylogenetic inference problems; we show that two arbitrarily chosen leaves, called anchors, can be used to estimate relative distances between all other pairs of leaves by inferring relevant quartet trees. This results in a family of distance-based tree inference methods, with running times ranging between quadratic to quartic in the number of leaves. We show in simulated studies that DISTIQUE has comparable accuracy to leading coalescent-based summary methods and reduced running times.

  10. Enhanced vapor transport in membrane distillation via functionalized carbon nanotubes anchored into electrospun nanofibres

    KAUST Repository

    An, Alicia Kyoungjin

    2017-01-30

    To ascertain membrane distillation (MD) as an emerging desalination technology to meet the global water challenge, development of membranes with ideal material properties is crucial. Functionalized carbon nanotubes (CNTs) were anchored to nanofibres of electrospun membranes. Covalent modification and fluorination of CNTs improved their dispersibility and interfacial interaction with the polymer membrane, resulting in well-aligned CNTs inside crystalline fibres with superhydrophobicity. Consideration for the chemical/physical properties of the CNT composite membranes and calculation of their theoretical fluxes revealed the mechanism of MD: CNTs facilitated the repulsive force for Knudsen and molecular diffusions, reduced the boundary-layer effect in viscous flow, and assisted surface diffusion, allowing for fast vapor transport with anti-wetting. This study shows that the role of CNTs and an optimal composite ratio can be used to reduce the gap between theoretical and experimental approaches to desalination.

  11. Failure modes of prestressed CFRP rods in a wedge anchored set-up

    DEFF Research Database (Denmark)

    Bennitz, Anders; Schmidt, Jacob Wittrup; Täljsten, Björn

    2009-01-01

    on how these failures can be avoided in theory and practice. From the experiences gained in the project, it is concluded that it is a challenging task to create a fully mechanical anchorage for CFRP tendons and that the failure margins are small between a successful and an unsuccesful anchorage system.......In the process of developing a new wedge anchorage to anchor prestressed CFRP rods, five different anchorage designs were manufactured. These designs have led to a constantly increased ultimate failure load of the prestressing system and an eventual load level above 95% of the ultimate failure load...... of the rod was achieved. If 100% efficiency is achieved the anchorage does not reduce the capacity of the system, but failure is then governed by the capacity of the rod itself, which is considered favourable and required by several guidelines. In the process seven different failure modes were identified...

  12. Anchoring novel molecular biomarker responses to traditional responses in fish exposed to environmental contamination

    Energy Technology Data Exchange (ETDEWEB)

    Nogueira, Patricia [CESAM and Departamento de Biologia, Universidade de Aveiro, Campus de Santiago, 3810-193 Aveiro (Portugal); Department of Biology and Environmental Science, University of Sussex, Falmer, Brighton BN1 9QJ (United Kingdom); Pacheco, Mario [CESAM and Departamento de Biologia, Universidade de Aveiro, Campus de Santiago, 3810-193 Aveiro (Portugal); Lourdes Pereira, M. [CICECO and Departamento de Biologia, Universidade de Aveiro, Campus de Santiago, 3810-193 Aveiro (Portugal); Mendo, Sonia [CESAM and Departamento de Biologia, Universidade de Aveiro, Campus de Santiago, 3810-193 Aveiro (Portugal); Rotchell, Jeanette M., E-mail: J.Rotchell@sussex.ac.u [Department of Biology and Environmental Science, University of Sussex, Falmer, Brighton BN1 9QJ (United Kingdom)

    2010-05-15

    The responses of Dicentrarchus labrax and Liza aurata to aquatic pollution were assessed in a contaminated coastal lagoon, using both traditional and novel biomarkers combined. DNA damage, assessed by comet assay, was higher in both fish species from the contaminated sites, whereas levels of cytochrome P450 1A1 gene expression were not significantly altered. The liver histopathological analysis also revealed significant lesions in fish from contaminated sites. Alterations in ras and xpf genes were analysed and additional pollutant-responsive genes were identified. While no alterations were found in ras gene, a downregulation of xpf gene was observed in D. labrax from a contaminated site. Suppression subtractive hybridization applied to D. labrax collected at a contaminated site, revealed altered expression in genes involved in energy metabolism, immune system activity and antioxidant response. The approach and results reported herein demonstrate the utility of anchoring traditional biomarker responses alongside novel biomarker responses. - Novel molecular biomarkers of aquatic environmental contamination in fish.

  13. Novel technique for proximal anchoring of penile prostheses in female-to-male transsexual.

    Science.gov (United States)

    Large, Michael C; Gottlieb, Lawrence J; Wille, Mark A; DeWolfe, Michael; Bales, Gregory T

    2009-08-01

    To present our initial experience with a novel technique for fixation of an inflatable penile prosthesis in the female-to-male transsexual in 2 patients. Proximal fixation of an inflatable penile prosthesis is challenging in the female-to-male transsexual because of the lack of normal corporal bodies. This technique uses a bone drill to create a fixation chamber in the symphysis pubis. A rear tip extender is then secured into bone, providing a stable fixation point for the proximal aspect of the penile cylinder. Two patients successfully underwent placement of a 2-cylinder inflatable penile prosthesis using this technique without any complications. At 8 and 13 months postoperatively, their Sexual Health Inventory for Men score was 23 and 25 of a possible 25 points, respectively. With modest follow-up, bone anchoring appears to provide improved support and better performance of the inflatable penile implant in the female-to-male transsexual patient.

  14. Anchoring novel molecular biomarker responses to traditional responses in fish exposed to environmental contamination

    International Nuclear Information System (INIS)

    Nogueira, Patricia; Pacheco, Mario; Lourdes Pereira, M.; Mendo, Sonia; Rotchell, Jeanette M.

    2010-01-01

    The responses of Dicentrarchus labrax and Liza aurata to aquatic pollution were assessed in a contaminated coastal lagoon, using both traditional and novel biomarkers combined. DNA damage, assessed by comet assay, was higher in both fish species from the contaminated sites, whereas levels of cytochrome P450 1A1 gene expression were not significantly altered. The liver histopathological analysis also revealed significant lesions in fish from contaminated sites. Alterations in ras and xpf genes were analysed and additional pollutant-responsive genes were identified. While no alterations were found in ras gene, a downregulation of xpf gene was observed in D. labrax from a contaminated site. Suppression subtractive hybridization applied to D. labrax collected at a contaminated site, revealed altered expression in genes involved in energy metabolism, immune system activity and antioxidant response. The approach and results reported herein demonstrate the utility of anchoring traditional biomarker responses alongside novel biomarker responses. - Novel molecular biomarkers of aquatic environmental contamination in fish.

  15. Substrate-bound tyrosinase electrode using gold nanoparticles anchored to pyrroloquinoline quinone for a pesticide biosensor

    Energy Technology Data Exchange (ETDEWEB)

    Kim, G.Y.; Kang, M.S.; Shim, J.; Moon, S.H. [Gwangju Inst. of Science and Technology (Korea, Republic of). Dept. of Environmental Science and Engineering

    2008-07-01

    Enzyme electrodes are now being considered for use in the detection of pesticides. However, the electrodes do not have the sensitivity to detect low concentration pesticides, and external substrates are needed to measure changes in enzyme activity. This study discussed a chemical species designed to mimic a substrate in the preparation of a tyrosinase (TYR) electrode for use without substrate standard solutions. Pyrroloquinolone quinone (PQQ) was integrated within the tyrosinase electrode and used as an assimilated substrate for measuring the pesticide. Gold (Au) nanoparticles were also used to detect low concentration pesticides. The TYR was immobilized on the PQQ-anchored Au nanoparticles by a covalent bond. The tethered PQQ was then reduced by obtaining 2-electrons from the electrode. The study showed that the substrate-bound enzyme electrode can be used to detect pesticide without a substrate standard solution through the immobilization of the enzyme and the substrate on the Au nanoparticles.

  16. The 1500 MW fast breeder reactor the double envelope-vessel anchored in concrete

    International Nuclear Information System (INIS)

    Bolvin, M.

    1981-01-01

    This paper givers an account of EDF investigations to reduce the investment costs of the 1500 MW Fast Reactor (RNR 1500) without prejudice to the safety requirements. It deals with the double envelope-vessel, designed to minimize radiation consequences in the event of accidental leakage in the main vessel. In the Fast Reactors in operation (PHOENIX), under construction (CRYS-MALVILLE), and under project (NR 1500), the double envelope-steel vessel hangs down from the upper part of the reactor block, its weight being approximately 300 t. In the new design, the vessel is fixed into the concrete which supports the main vessel, by means of steel anchors. A thermal insulation isolates it from the main vessel. The installation of coils in the concrete, next to the lining, allows for water circulation to cool the concrete. (orig./GL)

  17. Enhanced vapor transport in membrane distillation via functionalized carbon nanotubes anchored into electrospun nanofibres

    Science.gov (United States)

    Kyoungjin An, Alicia; Lee, Eui-Jong; Guo, Jiaxin; Jeong, Sanghyun; Lee, Jung-Gil; Ghaffour, Noreddine

    2017-01-01

    To ascertain membrane distillation (MD) as an emerging desalination technology to meet the global water challenge, development of membranes with ideal material properties is crucial. Functionalized carbon nanotubes (CNTs) were anchored to nanofibres of electrospun membranes. Covalent modification and fluorination of CNTs improved their dispersibility and interfacial interaction with the polymer membrane, resulting in well-aligned CNTs inside crystalline fibres with superhydrophobicity. Consideration for the chemical/physical properties of the CNT composite membranes and calculation of their theoretical fluxes revealed the mechanism of MD: CNTs facilitated the repulsive force for Knudsen and molecular diffusions, reduced the boundary-layer effect in viscous flow, and assisted surface diffusion, allowing for fast vapor transport with anti-wetting. This study shows that the role of CNTs and an optimal composite ratio can be used to reduce the gap between theoretical and experimental approaches to desalination.

  18. Electrolyte gated TFT biosensors based on the Donnan's capacitance of anchored biomolecules

    Science.gov (United States)

    Manoli, Kyriaki; Palazzo, Gerardo; Macchia, Eleonora; Tiwari, Amber; Di Franco, Cinzia; Scamarcio, Gaetano; Favia, Pietro; Mallardi, Antonia; Torsi, Luisa

    2017-08-01

    Biodetection using electrolyte gated field effect transistors has been mainly correlated to charge modulated transduction. Therefore, such platforms are designed and studied for limited applications involving relatively small charged species and much care is taken in the operating conditions particularly pH and salt concentration (ionic strength). However, there are several reports suggesting that the device conductance can also be very sensitive towards variations in the capacitance coupling. Understanding the sensing mechanism is important for further exploitation of these promising sensors in broader range of applications. In this paper, we present a thorough and in depth study of a multilayer protein system coupled to an electrolyte gated transistor. It is demonstrated that detection associated to a binding event taking place at a distance of 30 nm far from the organic semiconductor-electrolyte interface is possible and the device conductance is dominated by Donnan's capacitance of anchored biomolecules.

  19. Anchor proximal migration in the medial patellofemoral ligament reconstruction in skeletally immature patients

    Directory of Open Access Journals (Sweden)

    Fabiano Kupczik

    2013-09-01

    Full Text Available The medial patellofemoral ligament (MPFL injury has been considered instrumental in lateral patellar instability after patellar dislocation. Consequently, the focus on the study of this ligament reconstruction has increased in recent years. The MPFL femoral anatomical origin point has great importance at the moment of reconstruction surgery, because a graft fixation in a non anatomical position may result in medial overload, medial subluxation of the patella or excessive tensioning of the graft with subsequent failure. In the pediatric population, the location of this point is highlighted by the presence of femoral physis. The literature is still controversial regarding the best placement of the graft. We describe two cases of skeletally immature patients in whom LPFM reconstruction was performed. The femoral fixation was through anchors that were placed above the physis. With the growth and development of the patients, the femoral origin point of the graft moved proximally, resulting in failure in these two cases.

  20. Bone-anchored hearing aids are effective and associated with a high degree of satisfaction

    DEFF Research Database (Denmark)

    Gardell, Ida Sofie Kristina; Andresen, Kathrine; Faber, Christian Emil

    2015-01-01

    -2013-period. The questionnaire was a combination of Satisfaction with Amplification in Daily Life questions from the Hearing Aid Research Lab at the University of Memphis and questions used in a previous Danish study. We also used data from each patient's medical records. All information was collected......INTRODUCTION: The objective of this study was to evaluate patients' satisfaction with bone-anchored hearing aids (BAHA). METHODS: This study was retrospective and based on a postal questionnaire. The study sample consisted of patients undergoing surgery at Odense University Hospital in the 1992...... in one-on-one conversations. CONCLUSION: BAHA is helpful in one-on-one conversations in quiet surroundings. Sound quality in group situations seems to be the main problem associated with BAHA. However, this study showed that BAHA is an effective hearing aid that is associated with a high degree...

  1. Organisation, ‘anchoring’ of knowledge, and innovation in the construction industry

    DEFF Research Database (Denmark)

    Drejer, Ina; Vinding, Anker Lund

    2004-01-01

    explanation for the relatively poor innovation performance of the industry. Using survey data from the Danish construction industry the paper investigates the importance of learning and ?anchoring? of project specific knowledge within the firms for facilitating engagement in innovative activities...... at the firm level. The data refer to the overall Danish construction industry, as well as a specific region, North Jutland, which is relatively specialised in construction. By using latent class and regression analysis the results show that firms, which to a high extent make use of partnering and other...... that temporary interorganisational projects may cause in relation to continuous learning at the firm level. These results may also have implications for project organising firms outside the construction industry. A characteristic feature of the construction industry is the widespread use of project organisation...

  2. Subdural Hematoma: A Rare Adverse Complication From Bone-Anchored Hearing Aid Placement.

    Science.gov (United States)

    Amin, Nikul; Aymat-Torrente, Antonio

    2017-03-01

    Bone-anchored hearing aids (BAHA) are bone conduction hearing aids commonly implantated by Ear, Nose, and Throat surgeons. We present the first documented case of a subdural hematoma secondary to primary fixation of a BAHA. We present a 65-year-old male patient undergoing a left sided BAHA for bilateral chronic ear infections and difficulty wearing conventional hearing aids. The procedure was uneventful, however, the patient developed a postoperative large acute left temporoparietal intracerebral hematoma associated with an ipsilateral acute subdural hematoma. This required emergency transfer to the local tertiary neurosurgical center for a left decompressive craniotomy and evacuation of the hematoma. The patient required a prolonged stay on an intensive care unit and was eventually discharged to the community for on-going neurological rehabilitation. This is a rare and devastating complication BAHA surgery. Otologist, general ENT surgeons, and neurosurgeons should be aware of this life-threatening complication of BAHA surgery.

  3. Bone-anchored hearing aid and skin graft removal with subsequent cochlear implantation.

    Science.gov (United States)

    Britt, Christopher J; Coughlin, Adam R; Gubbels, Samuel P

    2016-11-01

    We describe a novel technique of scalp flap rearrangement for cochlear implant (CI) candidates who have previously undergone ipsilateral bone-anchored hearing aid (BAHA) placement. One patient with single-sided deafness (SSD) underwent removal of a BAHA with subsequent scalp rearrangement for coverage of the implant site. After adequate healing of the scalp rotational flap, he underwent uncomplicated cochlear implantation without soft tissue complications. With increasing utilization of CIs in SSD, there will be more patients undergoing cochlear implantation who have previously had a BAHA. We present a novel method for accomplishing this goal while minimizing the risk of soft tissue complications. Laryngoscope, 126:2601-2604, 2016. © 2016 The American Laryngological, Rhinological and Otological Society, Inc.

  4. [Self-rated efficacy in bilateral aural atresia patients using bone-anchored hearing aid].

    Science.gov (United States)

    Yue, Fan; Yibei, Wang; Zhen, Wang; Pu, Wang; Xiaowei, Chen

    2015-03-01

    Using questionnaires to evaluate the audiological benefit and satisfaction of bilateral aural atresia patients with bone-anchored hearing aid (Baha). Implanted Baha user questionnaire was applied to 19 patients suffering bilateral aural atresia, and 15 of the patients were evaluated with abbreviated profile of hearing aid benefit (APHAB). Glasgow children's benefit inventory (GCBI) was used to measure subjective benefit of patients under the age of 18. The Baha user questionnaire demonstrated great satisfaction. The mean Baha scores for the subdomains of ease of communication (EC), backgroud noise (BN) and revereration (RV) were decreased by 54.6 ± 10.2 (t = 20.6, P hearing ability and quality of life of patients with bilateral aural atresia.

  5. The nucleoplasmin homolog NLP mediates centromere clustering and anchoring to the nucleolus.

    Science.gov (United States)

    Padeken, Jan; Mendiburo, María José; Chlamydas, Sarantis; Schwarz, Hans-Jürgen; Kremmer, Elisabeth; Heun, Patrick

    2013-04-25

    Centromere clustering during interphase is a phenomenon known to occur in many different organisms and cell types, yet neither the factors involved nor their physiological relevance is well understood. Using Drosophila tissue culture cells and flies, we identified a network of proteins, including the nucleoplasmin-like protein (NLP), the insulator protein CTCF, and the nucleolus protein Modulo, to be essential for the positioning of centromeres. Artificial targeting further demonstrated that NLP and CTCF are sufficient for clustering, while Modulo serves as the anchor to the nucleolus. Centromere clustering was found to depend on centric chromatin rather than specific DNA sequences. Moreover, unclustering of centromeres results in the spatial destabilization of pericentric heterochromatin organization, leading to partial defects in the silencing of repetitive elements, defects during chromosome segregation, and genome instability. Copyright © 2013 Elsevier Inc. All rights reserved.

  6. Abolishing Cell Wall Glycosylphosphatidylinositol-Anchored Proteins in Candida albicans Enhances Recognition by Host Dectin-1.

    Science.gov (United States)

    Shen, Hui; Chen, Si Min; Liu, Wei; Zhu, Fang; He, Li Juan; Zhang, Jun Dong; Zhang, Shi Qun; Yan, Lan; Xu, Zheng; Xu, Guo Tong; An, Mao Mao; Jiang, Yuan Ying

    2015-07-01

    Fungi can shield surface pathogen-associated molecular patterns (PAMPs) for evading host immune attack. The most common and opportunistic human pathogen, Candida albicans, can shield β-(1 3)-glucan on the cell wall, one of the major PAMPs, to avoid host phagocyte Dectin-1 recognition. The way to interfere in the shielding process for more effective antifungal defense is not well established. In this study, we found that deletion of the C. albicans GPI7 gene, which was responsible for adding ethanolaminephosphate to the second mannose in glycosylphosphatidylinositol (GPI) biosynthesis, could block the attachment of most GPI-anchored cell wall proteins (GPI-CWPs) to the cell wall and subsequently unmask the concealed β-(1,3)-glucan. Neutrophils could kill the uncloaked gpi7 mutant more efficiently with an augmented respiratory burst. The gpi7 mutant also stimulated Dectin-1-dependent immune responses of macrophages, including activation of nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) pathways and secretion of specific cytokines, such as tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), and IL-12p40. Furthermore, the gpi7 null mutant could induce an enhanced inflammatory response through promoting significant recruitment of neutrophils and monocytes and could stimulate stronger Th1 and Th17 cell responses to fungal infections in vivo. These in vivo phenotypes also were Dectin-1 dependent. Thus, we assume that GPI-CWPs are involved in the immune mechanism of C. albicans escaping from host recognition by Dectin-1. Our studies also indicate that the blockage of GPI anchor synthesis is a strategy to inhibit C. albicans evading host recognition. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

  7. On the evaluation of a superpower sound processor for bone-anchored hearing.

    Science.gov (United States)

    Bosman, A J; Kruyt, I J; Mylanus, E A M; Hol, M K S; Snik, A F M

    2018-04-01

    Performance of a superpower bone-anchored hearing aid (Baha), the Baha Cordelle from Cochlear Bone-Anchored Solutions (BCD1), was compared to its successor, the Baha 5 SuperPower (BCD2). A comparative study in which each patient served as its own control. Tertiary clinic. Ten experienced BCD1 users with profound mixed hearing loss. For comparison, data from another study with 10 experienced users with a severe mixed hearing loss using a Cochlear Baha 5 power sound processor (BCD-P) were included. Speech reception thresholds in noise and APHAB and SSQ questionnaires. Speech reception thresholds for the digits-in-noise (DIN) test were significantly lower (P  5%) from the BCD2 values. With the APHAB questionnaire scores were significantly lower, that is more favourable, for the ease of communication (P  5%). Scores for the speech and quality domains of the SSQ questionnaire were significantly higher, that is more favourable, for BCD2 than for BCD1. APHAB and SSQ scores for BCD-P were not significantly different from those for BCD2 (P > 5%). Data for BCD2 in profound mixed loss are similar to those for BCD-P and a severe mixed loss. Of 10 patients, 2 expressed a strong preference for BCD2 over BCD1, and 7 patients had a preference for BCD2 over BCD1. One patient preferred BCD1 because of its built-in telecoil facility. © 2017 The Authors. Clinical Otolaryngology Published by John Wiley & Sons Ltd.

  8. Development of the Career Anchors Scale among Occupational Health Nurses in Japan

    Science.gov (United States)

    Kubo, Yoshiko; Hatono, Yoko; Kubo, Tomohide; Shimamoto, Satoko; Nakatani, Junko; Burgel, Barbara J.

    2016-01-01

    Objectives: This study aimed to develop the Career Anchors Scale among Occupational Health Nurses (CASOHN) and evaluate its reliability and validity. Methods: Scale items were developed through a qualitative inductive analysis of interview data, and items were revised following an examination of content validity by experts and occupational health nurses (OHNs), resulting in a provisional scale of 41 items. A total of 745 OHNs (response rate 45.2%) affiliated with the Japan Society for Occupational Health participated in the self-administered questionnaire survey. Results: Two items were deleted based on item-total correlations. Factor analysis was then conducted on the remaining 39 items to examine construct validity. An exploratory factor analysis with a main factor method and promax rotation resulted in the extraction of six factors. The variance contribution ratios of the six factors were 37.45, 7.01, 5.86, 4.95, 4.16, and 3.19%. The cumulative contribution ratio was 62.62%. The factors were named as follows: Demonstrating expertise and considering position in work (Factor 1); Management skills for effective work (Factor 2); Supporting health improvement in groups and organizations (Factor 3); Providing employee-focused support (Factor 4); Collaborating with occupational health team members and personnel (Factor 5); and Compatibility of work and private life (Factor 6). The confidence coefficient determined by the split-half method was 0.85. Cronbach's alpha coefficient for the overall scale was 0.95, whereas those of the six subscales were 0.88, 0.90, 0.91, 0.80, 0.85, and 0.79, respectively. Conclusions: CASOHN was found to be valid and reliable for measuring career anchors among OHNs in Japan. PMID:27725484

  9. Good isometric and isokinetic power restoration after distal biceps tendon repair with anchors.

    Science.gov (United States)

    Suda, Arnold J; Prajitno, Julia; Grützner, Paul A; Tinelli, Marco

    2017-07-01

    Distal biceps brachii tendon rupture can lead to 30-40% power loss of elbow flexion and up to 50% of forearm supination. Re-fixation of the distal biceps brachii tendon is recommended to warrant an adequate quality of the patient's life. This study reports the isometric and isokinetic results after anchor re-fixation 2.5 years after surgery. Between 2007 and 2010, 69 patients with distal biceps brachii tendon tear underwent a suture anchor reattachment. During the follow-up examination, a questionnaire and DASH score were filled in, the circumferences of the arm were measured, range of motion was collected, and different trials were conducted at the BTE Primus RS™ (Baltimore Therapeutic Equipment) on both arms. 49 patients (71%) were reinvestigated with a follow-up of 32 months (11-58 months). A significant difference was found in the ability of elbow flexion between the affected arm and the opposite side as well as in pronation and supination. In elbow flexion and extension as well as in pronation and supination of the forearm, the strength was significantly diminished. 32 months after surgical re-fixation of the distal biceps brachii tendon rupture, strength in all exercises is marginally reduced in comparison to the opposite arm. Re-fixation of the distal biceps brachii tendon is an adequate method to return the range of motion and the strength in the elbow joint to an almost normal level and that gives rise to a high level of patient satisfaction. Level III, case-control study.

  10. Development of the Career Anchors Scale among Occupational Health Nurses in Japan.

    Science.gov (United States)

    Kubo, Yoshiko; Hatono, Yoko; Kubo, Tomohide; Shimamoto, Satoko; Nakatani, Junko; Burgel, Barbara J

    2016-11-29

    This study aimed to develop the Career Anchors Scale among Occupational Health Nurses (CASOHN) and evaluate its reliability and validity. Scale items were developed through a qualitative inductive analysis of interview data, and items were revised following an examination of content validity by experts and occupational health nurses (OHNs), resulting in a provisional scale of 41 items. A total of 745 OHNs (response rate 45.2%) affiliated with the Japan Society for Occupational Health participated in the self-administered questionnaire survey. Two items were deleted based on item-total correlations. Factor analysis was then conducted on the remaining 39 items to examine construct validity. An exploratory factor analysis with a main factor method and promax rotation resulted in the extraction of six factors. The variance contribution ratios of the six factors were 37.45, 7.01, 5.86, 4.95, 4.16, and 3.19%. The cumulative contribution ratio was 62.62%. The factors were named as follows: Demonstrating expertise and considering position in work (Factor 1); Management skills for effective work (Factor 2); Supporting health improvement in groups and organizations (Factor 3); Providing employee-focused support (Factor 4); Collaborating with occupational health team members and personnel (Factor 5); and Compatibility of work and private life (Factor 6). The confidence coefficient determined by the split-half method was 0.85. Cronbach's alpha coefficient for the overall scale was 0.95, whereas those of the six subscales were 0.88, 0.90, 0.91, 0.80, 0.85, and 0.79, respectively. CASOHN was found to be valid and reliable for measuring career anchors among OHNs in Japan.

  11. Bone-anchored titanium implants for auricular rehabilitation: case report and review of literature

    Directory of Open Access Journals (Sweden)

    Emne Hammoud Gumieiro

    Full Text Available CONTEXT AND OBJECTIVE: Osseointegrated implants have acquired an important role in the prosthetic rehabilitation of patients with craniofacial defects. The main indications are lack of local tissue for autogenous reconstruction, previous reconstruction failure and selection of this technique by the patient. This paper presents a clinical case and discusses indications and advantages of the osseointegrated implant technique for retention of auricular prostheses. TYPE OF STUDY: Case report, Universidade Federal de São Paulo (UNIFESP. METHODS: A female patient received three auricular implants after surgical resection of a hemangioma in her left ear. The time taken for osseointegration of the temporal bone was three months. After fabrication of the implant-retained auricular prosthesis, the patient was monitored for 12 months. RESULTS: The clinical parameters evaluated showed good postoperative healing, healthy peri-implant tissue, good hygiene and no loss of implants. Good hygiene combined with thin and immobile peri-implant soft tissues resulted in minimal complications. Craniofacial implant integration appears to be site-dependent; increasing age affects osseointegration in the temporal bone. The frequency of adverse skin reactions in peri-implant tissues is generally low. CONCLUSION: The surgical technique for rehabilitation using implant-retained auricular prostheses seems to be simple. It is associated with low rates of adverse skin reactions and long-term complications. Prostheses anchored by osseointegrated implants seem to provide better retention than do prostheses supported on spectacle frames, less risk of discoloration through the use of adhesives and better esthetic results than do prostheses anchored in the surgical cavity

  12. Auditory brainstem and cortical potentials following bone-anchored hearing aid stimulation.

    Science.gov (United States)

    Rahne, Torsten; Ehelebe, Thomas; Rasinski, Christine; Götze, Gerrit

    2010-11-30

    Patients suffering from conductive or mixed hearing loss and Single-Sided Deafness may benefit from implantable hearing devices relying on bone conducted auditory stimulation. However, with only passively cooperative patients, objective methods are needed to estimate the aided and unaided pure-tone audiogram. This study focuses on the feasibility aspect of an electrophysiological determination of the hearing thresholds with bone-anchored hearing aid stimulation. Therefore, 10 normal-hearing subjects were provided with a Baha Intenso (Cochlear Ltd.) which was temporarily connected to the Baha Softband (Cochlear Ltd.). Auditory evoked potentials were measured by auditory stimulation paradigm used in clinical routine. The amplitudes, latencies, and thresholds of the resulting auditory brainstem responses (ABR) and the cortically evoked responses (CAEP) were correlated with the respective responses without the use of the Baha Intenso. The recording of ABR and CAEP by delivering the stimuli to the Baha results in response waveforms which are comparable to those evoked by earphone stimulation and appears appropriate to be measured using the Baha Intenso as stimulator. At the ABR recordings a stimulus artifact at higher stimulation levels and a constant latency shift caused by the Baha Intenso has to be considered. The CAEP recording appeared promising as a frequency specific objective method to approve the fitting of bone-anchored hearing aids. At all measurements, the ABR and CAEP thresholds seem to be consistent with the normal hearing of the investigated participants. Thus, a recording of auditory evoked potentials using a Baha is in general possible if specific limitations are considered. Copyright © 2010 Elsevier B.V. All rights reserved.

  13. Benefit and quality of life in older bone-anchored hearing aid users.

    Science.gov (United States)

    de Wolf, Maarten J F; Shival, My-Linh C; Hol, Myrthe K S; Mylanus, Emmanuel A M; Cremers, Cor W R J; Snik, Ad F M

    2010-07-01

    Benefit and quality-of-life analysis in the older adult bone-anchored hearing aid (BAHA) users. Retrospective evaluation. Four questionnaires (Glasgow Benefit Inventory, Abbreviated Profile of Hearing Aid Benefit [APHAB], Nijmegen Cochlear Implant Questionnaire [NCIQ], and the Hearing Handicap Inventory for the Elderly screening version [HHIE-S]) were used. The response rate was 80%, mean age was 75 years (range, 62-93 yr), and mean pure-tone average at frequencies of 500, 1,000, 2,000, and 4,000 Hz for bone conduction was 42 +/- 13 dBHL. More than 80% of the patients were using their BAHA for more than 8 hours a day. To obtain a "snapshot" of current BAHA use, the NCIQ, HHIE-S, and the APHAB were used. The NCIQ showed good disability and handicap results (score range, 49-64). The HHIE-S showed that 60% of the patients had a mild to moderate handicap. The APHAB aided scores ranged from 39 to 58%. Mean benefit scores of the Glasgow Benefit Inventory were positive in 112 of the 134 patients (84%). The APHAB showed clinically significantly more benefit with the BAHA than with the previous aided or unaided situation. A trend could be seen-the higher the pure-tone average at frequencies of 500, 1,000, 2,000, and 4,000 Hz for bone conduction, the smaller the mean benefit scores on the questionnaires. Bone-anchored hearing aid users aged 60 years or older were able to place and handle the device very adequately and clean the skin around the implant. Most patients reported comparable or increased general benefit and good quality of life with the BAHA.

  14. A Retrospective Review of Temporal Bone Imaging With Respect to Bone-Anchored Hearing Aid Placement.

    Science.gov (United States)

    Baker, Aaron R; Fanelli, David G; Kanekar, Sangam; Isildak, Huseyin

    2017-01-01

    Current bone-anchored hearing aid (BAHA) guidelines recommend placement of the titanium implant 5 to 7 cm posterior to the ear canal. Previous studies show that bone conducted hearing is maximized the closer the transducer is to the cochlea. We aim to investigate the position of the sigmoid sinus with respect to BAHA implants to determine whether they may be safely placed closer to the ear canal in patients with chronic ear disease, enhancing the amplification available to the patient. We performed a retrospective review of high-resolution temporal bone computed tomographies (CTs), comparing multiple measurements between ears with chronic ear disease and normal controls. Images were obtained at a single academic medical center. Eighty patients (160 ears) with temporal bone CTs performed between 2006 and 2009 were measured. Patients with chronic ear disease were identified by international statistical classification of diseases and related health problems, revision 9 code and confirmation by review of the imaging. Measurements were made on axial CT slices from a point 1 cm posterior to the sigmoid sinus to the posterior margin of the external canal. The squamous temporal bone thickness was also measured at this point. Forty-seven patients (55 ears) had chronic ear disease. Distance from the posterior canal was significantly different between normal and diseased ears (36.3 mm versus 33.5 mm, p bone thickness varied widely, and was similar between groups (6.9 mm versus 6.8 mm, p = 0.76). According to our data, titanium implants for bone-anchored hearing aids may be safely placed closer to the external canal than the current recommendations. This could allow for better transduction as well as sound localization in BAHA patients.

  15. A TV Reporter, an Adviser's Internship, a TV Anchor/Reporter, an Assignment Editor, a TV Photojournalist's Bag of Tricks.

    Science.gov (United States)

    Patrow, Kris; Youngblood, Steve; Madden, Tracy; Hamburger, Jeff; Johnson, Kevin

    2000-01-01

    Intends to help high school journalism students understand the field they are preparing for by presenting brief descriptions of a day in the work life of a television news reporter, a TV anchor/reporter, and a television news assignment editor. Describes the five-week internship at a local television news station of a journalism instructor. (SR)

  16. A unifying mechanism accounts for sensing of membrane curvature by BAR domains, amphipathic helices and membrane-anchored proteins

    DEFF Research Database (Denmark)

    Bhatia, Vikram Kjøller; Hatzakis, Nikos; Stamou, Dimitrios

    2010-01-01

    itself. We thus anticipate that membrane curvature will promote the redistribution of proteins that are anchored in membranes through any type of hydrophobic moiety, a thesis that broadens tremendously the implications of membrane curvature for protein sorting, trafficking and signaling in cell biology....

  17. Integrating a WebQuest in the Primary School Curriculum Using Anchored Instruction: Effect on Learning Outcomes

    NARCIS (Netherlands)

    Segers, P.C.J.; Droop, W.; Verhoeven, L.T.W.

    2010-01-01

    Based on a literature review, a means for integrating WebQuests in day-to-day school activities is introduced using principles of Anchored Instruction. Following these ideas in an effect study, including 109 children in 4th, 5th and 6th grade, significant learning gains were found, with a large

  18. A-kinase anchoring protein 150 in the mouse brain is concentrated in areas involved in learning and memory

    NARCIS (Netherlands)

    Ostroveanu, Anghelus; Van der Zee, Eddy A.; Dolga, Amalia M.; Luiten, Paul G. M.; Eisel, Ulrich L. M.; Nijholt, Ingrid M.

    2007-01-01

    A-kinase anchoring proteins (AKAPs) form large macromolecular signaling complexes that specifically target cAMP-dependent protein kinase (PKA) to unique subcellular compartments and thus, provide high specificity to PKA signaling. For example, the AKAP79/150 family tethers PKA, PKC and PP2B to

  19. Does the design of mini slings anchoring systems really matter? A biomechanical comparison between Mini Arc™ and Ophira™.

    Science.gov (United States)

    Santos-Souza, R; Rodrigues-Palma, P C; Goulart-Fernandes-Dias, F; Teixeira-Siniscalchi, R; Zanettini-Riccetto, C L

    2016-11-01

    Currently, a sling implant is the standard treatment for stress urinary incontinence in women. To be effective, they require an adequate anchoring system. The aim of this study is compare biomechanical features of fixation systems of two mini slings models available on the market (Ophira™ and Mini Arc™) through a tensile test. Anchoring devices of each sling were surgically implanted in abdominal wall of 15 rats divided into three groups of five animals which were arranged according to the date of post implant euthanasia on 7, 14 and 30 days. Abdominal walls of rats were extracted on bloc containing the anchoring system and were submitted to a tensile strength test to measure the maximum load and elongation until device avulsion from the tissue. The results were compared using Student test t and a 5% cut off was considered significant. The Ophira™ mini sling fixation system demanded a greater maximum load and developed a longer stretch for avulsion from the implanted site at all moments evaluated (p value less than 0.05). There were significant differences in fixation patterns of the anchoring systems, which were exclusively related to their designs. The Ophira™ mini sling fixation device provided better fixation to the abdominal wall of rats compared to the Mini Arc™ device, even in the late post implant period. Copyright © 2016 AEU. Publicado por Elsevier España, S.L.U. All rights reserved.

  20. Assessment of the cross-national validity of an End-anchored 9-point hedonic product liking scale

    NARCIS (Netherlands)

    Beuckelaer, de A.; Zeeman, M.; Trijp, van J.C.M.

    2015-01-01

    Abstract An end-anchored 9-point hedonic product liking (PL) scale is an easy-to-apply instrument to examine consumers’ PL. Because 9-point hedonic PL scales are also popular in cross-national research, strong demands are put on its cross-national equivalence, that is, the absence of cross-national