WorldWideScience

Sample records for anchorages

  1. TERRAIN, Anchorage, Alaska

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — The Anchorage AOI consists of seven areas. These areas were to be collected to the 'highest' accuracy requirement. Ground Control is collected throughout the AOI...

  2. Alarm in Anchorage.

    Science.gov (United States)

    Campbell, Larry

    1991-01-01

    A possible sex scandal involving a teacher and a teenage student rocked the community in Anchorage, Alaska. Privacy and labor laws and union contract forbade board members from discussing the retirement deal that had been negotiated with the accused teacher. Hindsight suggests board members should have shared what information they could with the…

  3. New concept of physiologic anchorage control

    OpenAIRE

    Tian-Min Xu

    2015-01-01

    Molar anchorage loss in extraction case is believed due to the reaction of mechanical force applied to retract anterior teeth. While it may be close to truth in adult patients, it is certainly not true in adolescents. Studies on molar growth show upper molar move forward as mandible growing forward, probably through intercuspation force. Hence, for adolescents, molar anchorage loss shall consist of two parts. One is from retraction force - mechanical anchorage loss; another from biologic forc...

  4. Recommended approaches for resolution of anchorage outliers

    International Nuclear Information System (INIS)

    In developing anchorage qualification guidelines for the Nuclear Regulatory Commission Unresolved Safety Issue (USI) A-46, it was recognized that the plants involved in the program had used a wide variety of details to anchor safety-related equipment. The diversity in anchoring detailing has made it impractical to develop one guideline to cover all possible existing anchorage details in A-46 plants. Therefore, a generic approach was taken to provide base level criteria that would be applicable to all plants, recognizing that plant-specific criteria development and anchorage evaluation would be necessary to resolve issues not specifically addressed in the Generic Implementation Procedure (GIP). Within the GIP terminology, equipment having one or more of these issues is referred to as outliers. A comprehensive study was conducted to address the resolution of anchorage outliers. This paper presents classical approaches for evaluation of two common outliers: Anchorage Gap Exceeding 0.25 Inch and Prying Load on Anchor Bolts

  5. On decisive factors of liner anchorage behaviour

    International Nuclear Information System (INIS)

    Design of reinforced and prestressed containments for nuclear power plants in the FRG shall be guided by DIN 25459; this also includes the structural behaviour of the liner. While the containment safety analysis is a more global matter, the liner and especially the liner anchorage behaviour concentrates on local effects which need a more refined local area description. Due to the predominant stiffness of the concrete structure liner failure analysis are performed by decoupling the steel membrane which is then only supported by anchorage springs. A comprehensive nonlinear analytical study is carried out to examine the anchorage behaviour. (Author)

  6. 76 FR 76295 - Anchorage Regulations; Wells, ME

    Science.gov (United States)

    2011-12-07

    ... rulemaking (NPRM) entitled ``Anchorage Regulations; Wells, Maine'' in the Federal Register (76 FR 52599). We..., Maine. All coordinates referenced use datum: NAD 83. Dated: November 21, 2011. Daniel A. Neptun,...

  7. Is skeletal anchorage changing the limit of orthodontics?

    DEFF Research Database (Denmark)

    Melsen, Birte

    2007-01-01

    and can be loaded immediately. The course will be addressed the following topics: Are the mini-implants replacing conventional anchorage? Why are orthodontic mini-implants necessary? The development of the skeletal anchorage systems The biological basis for the skeletal anchorage systems...... The characteristics of the different skeletal anchorage systems The insertion procedure The indications for the use of orthodontic mini-implants Treatment planning in relation to the use of mini-implants Case presentations......The limits for orthodontic treatment are often set by the lack of suitable anchorage. The mini-implant is used where conventional anchorage cannot be applied; not as a replacement for conventional anchorage. In patients with lack of teeth and reduced periodontium, skeletal anchorage allows...

  8. Paradigm shifts in orthodontic treatment with mini-implant anchorage

    Directory of Open Access Journals (Sweden)

    Johnny Joung-Lin Liaw

    2015-01-01

    Full Text Available After the applications of mini-implant anchorage, the envelope of orthodontic treatment was expanded and some treatment modes were changed because of more predictable tooth movement with empowered anchorage. The author tried to share his experience of TADs applications for clarifying the paradigm shifts of orthodontic treatment assisted with the mini-implant anchorage.

  9. Measuring the democratic anchorage of governance networks

    DEFF Research Database (Denmark)

    Fotel, Trine; Sørensen, Eva; Torfing, Jacob

    model helps to assess the democratic performance of specific governance networks and to gain knowledge about the critical factors that determine their degree of democratic anchorage. Such knowledge is crucial for developing proactive strategies for enhancing the democratic performance of specific...

  10. Orthodontic Anchorage Implants: State-of-the-art

    DEFF Research Database (Denmark)

    Melsen, Birte

    2007-01-01

    The limits of an orthodontic treatment are often set by the lack of suitable anchorage. The mini-implant is used where conventional anchorage cannot be applied and not as a replacement for conventional anchorage. In patients with lack of teeth and reduced periodontium, skeletal anchorage allows the...... will improve the reconstruction possibilities. The mini-implant has widened the orthodontic possibilities....... optimal positioning of the teeth following rehabilitation. Patients with need for inconsistent tooth movements, borderline surgical cases, can benefit from the use of the mini-implant and regeneration of alveolar process by tooth movement in edentulous molar regions and using mini-implants as anchorage...

  11. 76 FR 34197 - Anchorage; Change to Cottonwood Island Anchorage, Columbia River, Oregon and Washington

    Science.gov (United States)

    2011-06-13

    .... SUMMARY: The Coast Guard proposes to increase the size of the Cottonwood Island Anchorage on the Columbia River. The change is necessary to help ensure that there is sufficient space to accommodate vessels... regarding our public dockets in the January 17, 2008, issue of the Federal Register (73 FR 3316)....

  12. 77 FR 45988 - Anchorage Regulations; Great Chebeague Island, ME

    Science.gov (United States)

    2012-08-02

    ... Act notice regarding our public dockets in the January 17, 2008, issue of the Federal Register (73 FR... SECURITY Coast Guard 33 CFR Part 110 RIN 1625-AA01 Anchorage Regulations; Great Chebeague Island, ME AGENCY... six special anchorage areas in the vicinity of Great Chebeague Island, Maine. This proposed action...

  13. Anchorage of Main Reinforcement in Lightweight Aggregate Concrete Beams

    DEFF Research Database (Denmark)

    Larsen, Henning

    1999-01-01

    The paper deals with the anchorage of reinforcement bars at end supports in beam component made of lightweight aggregate concrete with open structure.......The paper deals with the anchorage of reinforcement bars at end supports in beam component made of lightweight aggregate concrete with open structure....

  14. 75 FR 76275 - Anchorage Regulations; Long Island Sound

    Science.gov (United States)

    2010-12-08

    ...In this rule the Coast Guard establishes seven anchorage grounds in Long Island Sound. These anchorages are located in Connecticut and New York State waters. This action is necessary to aid in facilitating the safe and secure anchoring and transiting of vessels, particularly deep draft vessels, transiting Long Island Sound or awaiting entry to a port or facility in New York and...

  15. [Zygomatic anchorage concept in full edentulism].

    Science.gov (United States)

    Malevez, C

    2012-09-01

    The zygoma anchorage concept for severe atrophy of the maxilla was developed by Brånemark in the 1980s. It concerned patients having undergone maxillectomy as well as patients with edentulous upper jaws and mild to severe maxillary atrophy. The concept was created and clinically developed in 1997, by placing two zygomatic implants and four standard ones to compensate sub-sinus bone resorption. It was applied later to patients presenting extremely severe maxillary atrophy, using the "zygoma quad" concept with the placement of four zygomatic implants. Zygoma anchorage is reliable in terms of osseo-integration and biomechanical support of screwed prostheses, according to frequently published data (overall survival rate ranging between 91 and 100%). The increasing practice of immediate loading makes it the treatment of choice for oral rehabilitation. It decreases surgical invasiveness and the delay between surgery and oral rehabilitation. It allows a quick social and professional reinsertion and increases the comfort and quality of life for patients with fully edentulous maxilla with mild, moderate, or severe atrophy. PMID:22920891

  16. Anchorage Arrival Scheduling Under Off-Nominal Weather Conditions

    Science.gov (United States)

    Grabbe, Shon; Chan, William N.; Mukherjee, Avijit

    2012-01-01

    Weather can cause flight diversions, passenger delays, additional fuel consumption and schedule disruptions at any high volume airport. The impacts are particularly acute at the Ted Stevens Anchorage International Airport in Anchorage, Alaska due to its importance as a major international portal. To minimize the impacts due to weather, a multi-stage scheduling process is employed that is iteratively executed, as updated aircraft demand and/or airport capacity data become available. The strategic scheduling algorithm assigns speed adjustments for flights that originate outside of Anchorage Center to achieve the proper demand and capacity balance. Similarly, an internal departure-scheduling algorithm assigns ground holds for pre-departure flights that originate from within Anchorage Center. Tactical flight controls in the form of airborne holding are employed to reactively account for system uncertainties. Real-world scenarios that were derived from the January 16, 2012 Anchorage visibility observations and the January 12, 2012 Anchorage arrival schedule were used to test the initial implementation of the scheduling algorithm in fast-time simulation experiments. Although over 90% of the flights in the scenarios arrived at Anchorage without requiring any delay, pre-departure scheduling was the dominant form of control for Anchorage arrivals. Additionally, tactical scheduling was used extensively in conjunction with the pre-departure scheduling to reactively compensate for uncertainties in the arrival demand. For long-haul flights, the strategic scheduling algorithm performed best when the scheduling horizon was greater than 1,000 nmi. With these long scheduling horizons, it was possible to absorb between ten and 12 minutes of delay through speed control alone. Unfortunately, the use of tactical scheduling, which resulted in airborne holding, was found to increase as the strategic scheduling horizon increased because of the additional uncertainty in the arrival times

  17. Explaining the democratic anchorage of governance networks

    DEFF Research Database (Denmark)

    Skelcher, Chris; Klijn, Erik-Hans; Kübler, Daniel; Sørensen, Eva; Sulivan, Helen

    2011-01-01

    Advances in understanding the democratic anchorage of governance networks require carefully designed and contextually grounded empirical analysis that take into account contextual factors. The article uses a conjectural framework to study the impact of the national democratic milieu on the...... relationship between network governance and representative institutions in four European countries: the United Kingdom, Switzerland, the Netherlands, and Denmark. The article shows that the distinction between majoritarian and consensus democracy as well as the varying strength of voluntary associations are...... important contextual factors that help explain cross-national differences in the relationship between governance networks and representative institutions. We conclude that a context of weak associationalism in majoritarian democracies facilitates the instrumentalization of networks by government actors...

  18. Urban contaminants project: Fish and Hood Creeks, Anchorage, Alaska

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Urbanization has decreased water quality and adversely impacted biological communities in the lakes and streams of Anchorage, Alaska (Hock, 1981; Brabets, 1987;...

  19. 75 FR 3641 - Television Broadcasting Services; Anchorage, AK

    Science.gov (United States)

    2010-01-22

    ... From the Federal Register Online via the Government Publishing Office FEDERAL COMMUNICATIONS COMMISSION 47 CFR Part 73 Television Broadcasting Services; Anchorage, AK AGENCY: Federal Communications... broadcasting. 0 For the reasons discussed in the preamble, the Federal Communications Commission amends 47...

  20. Essix retainer as a modified esthetic anchorage device

    OpenAIRE

    Kamlesh Kumar Garg; Ashish Mahendra; Sonahita Agarwal

    2014-01-01

    Essix based appliances have multiple uses in orthodontics, which greatly expand the many treatment options currently available. In office fabrication presents an additional asset and because Essix appliances are clear plastic, the result is esthetically pleasing to the eye. The current case report introduces a novel technique of correcting individual tooth rotations using Essix based anchorage appliance in patients with limited anchorage options because of missing teeth or severe crowding.

  1. Structural strengthening with prestressed CFRP strips with gradient anchorage

    OpenAIRE

    Michels, Julien; Sena-Cruz, José; Czaderski, Christoph; Motavalli, Masoud

    2013-01-01

    This paper presents the principle and the application of an innovative anchorage technique for prestressed carbon fiber–reinforced polymer (CFRP) strips in structural strengthening. Additionally, large-scale static loading tests of retrofitted concrete beams are shown. The gradient anchorage, based on the adhesive’s ability to undergo accelerated curing at high temperatures, consists of a purely concrete-adhesive strip connection without any mechanical devices, such as bolts or plates. In a f...

  2. FRP tendon anchorage in post-tensioned concrete structures

    DEFF Research Database (Denmark)

    Schmidt, Jacob Wittrup; Täljsten, Björn; Bennitz, Anders; Henning, Pedersen

    Strengthening of building structures by the use of various external post-tensioning steel tendon systems, is known to be a very efficient method. However, FRP as material in external post-tensioning projects has been investigated during the last decade. The advantages for this material are the high...... effective Young´s modulus and the high stress capacity in the linear elastic range of the material. The use of external tendons increases the requirements on the anchorage systems. This is in particular important when using un-bonded tendon systems, where the anchorage and deviators are the only force...... transfer points. The demand for high capacity anchorage tendons is fulfilled for steel tendons, but no competitive mechanical anchor has yet been developed for FRP tendon. A new small, reliable and more user friendly anchor has to be developed, before FRP tendons can be utilized with all of its capacity...

  3. Finite element simulation and testing of ISW CFRP anchorage

    DEFF Research Database (Denmark)

    Schmidt, Jacob Wittrup; Goltermann, Per; Hertz, Kristian Dahl

    2013-01-01

    modelled in the 3D finite Element program ABAQUS, just as digital image correlation (DIC) testing was performed to verify the finite element simulation. Also a new optimized design was produced to ensure that the finite element simulation and anchorage behaviour correlated well. It is seen that the...

  4. Tensile tests of basalt FRP rebars using chemical anchorages

    OpenAIRE

    Neagoe, Catalin Andrei; Gil Espert, Lluís

    2013-01-01

    In the current report are analyzed the experimental results of initial tensile tests of Basalt FRP (BFRP) rebars provided by VSL. The investigation was conducted in the laboratory of CER LITEM. Objectives of the study: to determine the tensile strengths of 6 mm and 8 mm basalt FRP rebars, and to determine what type of test setup and anchorage system is best suited for future tensile tests of BFRP bars.

  5. Tensile tests of basalt FRP rebars using mechanical anchorages

    OpenAIRE

    Neagoe, Catalin Andrei; Gil Espert, Lluís

    2013-01-01

    In the current report are analyzed the experimental results of initial tensile tests of Basalt FRP (BFRP) rebars provided by VSL. The investigation was conducted on the 19th of February 2013, in the laboratory of CER LITEM. Objectives of the study: to determine the tensile strengths of 6 mm and 8 mm basalt FRP rebars, and to determine what type of test setup and anchorage system is best suited for future tensile tests of BFRP bars.

  6. Optimizing Anterior En Masse Retraction with Miniscrew Anchorage

    Directory of Open Access Journals (Sweden)

    Pavankumar Janardan Vibhute

    2011-01-01

    Full Text Available In severely protrusive patients, skeletal anchorage from miniscrew is often used to avoid anchorage loss with preferred miniscrew location near centre of resistance (Cres of posterior teeth. Biomechanical requirement for directing retraction force towards Cres of posterior teeth demands the insertion of miniscrew in loose mucosa, where risk of infection and failure increases. In addition, undesirable biomechanical side effects on anterior and posterior segments may be possible in all three planes, when continuous arch sliding mechanics are installed with miniscrew anchorage. This paper describes technique of molar-stabilizing power arm (MSPA for simultaneous intrusion and retraction of anteriors with miniscrew placement at attached gingiva between 1st molar and 2nd premolar. Advantages of this technique include (i the need of miniscrews placement in loose mucosa apically near the Cres of the posterior teeth is eliminated, (ii the risk of infection and miniscrew failure is lowered since the miniscrew is placed in attached gingiva rather than the loose mucosa, and (iii by adjusting vertical length or replacing MSPA, alteration of the retraction force vector is possible in all three planes; thus, need of removal and repositioning of the miniscrew (e.g., in correction of occlusal cant can be eliminated.

  7. Image guided placement of temporary anchorage devices for tooth movement

    Energy Technology Data Exchange (ETDEWEB)

    Bahl-Palomo, L.; Bissada, N. [Case Western Reserve Univ. School of Dental Medicine, Dept. of Periodontics, Cleveland, OH (United States); Palomo, J.M.; Hans, M.G. [Case Western Reserve Univ. School of Dental Medicine, Dept. of Orthodontics, Cleveland, OH (United States)

    2007-06-15

    The aim of this project is to develop an image guided protocol for placement of a temporary anchorage device without surgically reflecting a mucoperiosteal flap. Eighteen orthodontic cases were selected for skeletal anchorage from the department of orthodontics at Case University. CBCT images of the subjects were taken using the Hitachi CB MercuRay system set at 15 mA, 120 kVp. CBCT images evaluated the ideal location for TAD placement in three dimensions. Horizontal and vertical linear measurements were taken from fixed dental landmarks to clearly define the location for placement. Transverse slices were used to evaluate the thickness of the buccal plate. Using the transverse view, the angle of insertion was determined such that the maximum buccal plate surface area would contact the screw. TADs were placed in the optimum location, with the most appropriate angle of insertion using a closed approach and with minimal local anesthesia and without flap elevation. Results: All TADs were placed without anatomic encroachment and enabled fixed orthodontic anchorage. (orig.)

  8. Image guided placement of temporary anchorage devices for tooth movement

    International Nuclear Information System (INIS)

    The aim of this project is to develop an image guided protocol for placement of a temporary anchorage device without surgically reflecting a mucoperiosteal flap. Eighteen orthodontic cases were selected for skeletal anchorage from the department of orthodontics at Case University. CBCT images of the subjects were taken using the Hitachi CB MercuRay system set at 15 mA, 120 kVp. CBCT images evaluated the ideal location for TAD placement in three dimensions. Horizontal and vertical linear measurements were taken from fixed dental landmarks to clearly define the location for placement. Transverse slices were used to evaluate the thickness of the buccal plate. Using the transverse view, the angle of insertion was determined such that the maximum buccal plate surface area would contact the screw. TADs were placed in the optimum location, with the most appropriate angle of insertion using a closed approach and with minimal local anesthesia and without flap elevation. Results: All TADs were placed without anatomic encroachment and enabled fixed orthodontic anchorage. (orig.)

  9. Optimizing anterior en masse retraction with miniscrew anchorage.

    Science.gov (United States)

    Vibhute, Pavankumar Janardan

    2011-01-01

    In severely protrusive patients, skeletal anchorage from miniscrew is often used to avoid anchorage loss with preferred miniscrew location near centre of resistance (Cres) of posterior teeth. Biomechanical requirement for directing retraction force towards Cres of posterior teeth demands the insertion of miniscrew in loose mucosa, where risk of infection and failure increases. In addition, undesirable biomechanical side effects on anterior and posterior segments may be possible in all three planes, when continuous arch sliding mechanics are installed with miniscrew anchorage. This paper describes technique of molar-stabilizing power arm (MSPA) for simultaneous intrusion and retraction of anteriors with miniscrew placement at attached gingiva between 1st molar and 2nd premolar. Advantages of this technique include (i) the need of miniscrews placement in loose mucosa apically near the Cres of the posterior teeth is eliminated, (ii) the risk of infection and miniscrew failure is lowered since the miniscrew is placed in attached gingiva rather than the loose mucosa, and (iii) by adjusting vertical length or replacing MSPA, alteration of the retraction force vector is possible in all three planes; thus, need of removal and repositioning of the miniscrew (e.g., in correction of occlusal cant) can be eliminated. PMID:22567438

  10. CFRP Mechanical Anchorage for Externally Strengthened RC Beams under Flexure

    Science.gov (United States)

    Ali, Alnadher; Abdalla, Jamal; Hawileh, Rami; Galal, Khaled

    De-bonding of carbon fiber reinforced polymers (CFRP) sheets and plates from the concrete substrate is one of the major reasons behind premature failures of beams that are externally strengthened with such CFRP materials. To delay or prevent de-bonding and therefore enhancing the load carrying capacity of strengthened beams, several anchorage systems were developed and used. This paper investigates the use of CFRP mechanical anchorage of CFRP sheets and plates used to externally strengthen reinforced concrete beams under flexure. The pin-and-fan shape CFRP anchor, which is custom-made from typical rolled fiber sheets and bundles of loose fiber is used. Several reinforced concrete beams were casted and tested in standard four-point bending scheme to study the effectiveness of this anchorage system. The beams were externally strengthened in flexure with bonded CFRP sheets and plates and then fastened to the soffit of the beams' using various patterns of CFRP anchors. It is observed that the CFRP plates begins to separate from the beams as soon as de-bonding occurs in specimens without CFRP anchors, while in beams with CFRP anchors de-bonding was delayed leading to increase in the load carrying capacity over the un-anchored strengthened beams.

  11. Mini-Implants in the Anchorage Armamentarium: New Paradigms in the Orthodontics

    OpenAIRE

    Masaru Yamaguchi; Toshihiro Inami; Ko Ito; Kazutaka Kasai; Yasuhiro Tanimoto

    2012-01-01

    Paradigms have started to shift in the orthodontic world since the introduction of mini-implants in the anchorage armamentarium. Various forms of skeletal anchorage, including miniscrews and miniplates, have been reported in the literature. Recently, great emphasis has been placed on the miniscrew type of temporary anchorage device (TAD). These devices are small, are implanted with a relatively simple surgical procedure, and increase the potential for better orthodontic results. Therefore, mi...

  12. Comparative photoelastic study of dental and skeletal anchorages in the canine retraction

    Directory of Open Access Journals (Sweden)

    Cristiane Aparecida de Assis Claro

    2014-01-01

    Full Text Available OBJECTIVE: To compare dental and skeletal anchorages in mandibular canine retraction by means of a stress distribution analysis. METHODS: A photoelastic model was produced from second molar to canine, without the first premolar, and mandibular canine retraction was simulated by a rubber band tied to two types of anchorage: dental anchorage, in the first molar attached to adjacent teeth, and skeletal anchorage with a hook simulating the mini-implant. The forces were applied 10 times and observed in a circular polariscope. The stresses located in the mandibular canine were recorded in 7 regions. The Mann-Whitney test was employed to compare the stress in each region and between both anchorage systems. The stresses in the mandibular canine periradicular regions were compared by the Kruskal-Wallis test. RESULTS: Stresses were similar in the cervical region and the middle third. In the apical third, the stresses associated with skeletal anchorage were higher than the stresses associated with dental anchorage. The results of the Kruskal-Wallis test showed that the highest stresses were identified in the cervical-distal, apical-distal, and apex regions with the use of dental anchorage, and in the apical-distal, apical-mesial, cervical-distal, and apex regions with the use of skeletal anchorage. CONCLUSIONS: The use of skeletal anchorage in canine retraction caused greater stress in the apical third than the use of dental anchorage, which indicates an intrusive component resulting from the direction of the force due to the position of the mini-implant and the bracket hook of the canine.

  13. Flexural Strengthening of RC Slabs with Prestressed CFRP Strips Using Different Anchorage Systems

    Directory of Open Access Journals (Sweden)

    José Sena-Cruz

    2015-10-01

    Full Text Available Externally Bonded Reinforcement (EBR technique has been widely used for flexural strengthening of concrete structures by using carbon fiber-reinforced polymers (CFRP. EBR technique offers several structural advantages when the CFRP material is prestressed. This paper presents an experimental and numerical study on reinforced (RC slabs strengthened in flexure with prestressed CFRP strips as a structural strengthening system. The strips are applied as an externally bonded reinforcement (EBR and anchored with either a mechanical or a gradient anchorage. The former foresees metallic anchorage plates fixed to the concrete substrate, while the latter is based on an accelerated epoxy resin curing followed by a segment-wise prestress force decrease at the strip ends. Both anchorage systems, in combination with different CFRP strip geometries, were subjected to static loading tests. It could be demonstrated that the composite strip’s performance is better exploited when prestressing is used, with slightly higher overall load carrying capacities for mechanical anchorages than for the gradient anchorage. The performed investigations by means of a cross-section analysis supported the experimental observation that in case a mechanical anchorage is used, progressive strip debonding changes the fully bonded configuration to an unbonded end-anchored system. The inclusion of defined debonding criteria for both the anchorage zones and free length between the anchorage regions allowed to precisely capture the ultimate loading forces.

  14. 77 FR 8252 - Adequacy Status of the Anchorage, Alaska, Carbon Monoxide Maintenance Plan for Transportation...

    Science.gov (United States)

    2012-02-14

    ... existing violations, or delay timely attainment of the national ambient air quality standards. The minimum... AGENCY Adequacy Status of the Anchorage, Alaska, Carbon Monoxide Maintenance Plan for Transportation... budget (MVEB) in the Anchorage, Alaska, Carbon Monoxide (CO) Maintenance Plan, submitted by the State...

  15. 78 FR 11097 - Artificial Island Anchorage No. 2 Partial Closure, Delaware River; Salem, NJ

    Science.gov (United States)

    2013-02-15

    .... SUPPLEMENTARY INFORMATION: Table of Acronyms DHS Department of Homeland Security FR Federal Register NPRM Notice... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Artificial Island Anchorage No. 2 Partial Closure... will be establishing a temporary safety zone around the southern portion of Anchorage 2...

  16. Mini-Implants in the Anchorage Armamentarium: New Paradigms in the Orthodontics

    Directory of Open Access Journals (Sweden)

    Masaru Yamaguchi

    2012-01-01

    Full Text Available Paradigms have started to shift in the orthodontic world since the introduction of mini-implants in the anchorage armamentarium. Various forms of skeletal anchorage, including miniscrews and miniplates, have been reported in the literature. Recently, great emphasis has been placed on the miniscrew type of temporary anchorage device (TAD. These devices are small, are implanted with a relatively simple surgical procedure, and increase the potential for better orthodontic results. Therefore, miniscrews not only free orthodontists from anchorage-demanding cases, but they also enable clinicians to have good control over tooth movement in 3 dimensions. The miniplate type also produces significant improvements in treatment outcomes and has widened the spectrum of orthodontics. The purpose of this paper is to update clinicians on the current concepts and versatile uses and clinical applications of skeletal anchorage in orthodontics.

  17. Analysis on Bearing Capacity of Tunnel-Type Anchorage of a Long-Span Suspension Bridge

    Institute of Scientific and Technical Information of China (English)

    Zhu Yu; Wei Jun; Yang Manjuan; Li Hao; Liu Hongqing

    2005-01-01

    Due to complicated rock structure and environment, a prototype test for a tunnel-type anchorage is infeasible. Based on the rock mass parameters from tests, a three-dimensional (3D) elasto-plastic analysis was performed to simulate the influence of the construction procedure of Siduhe bridge with tunnel-type anchorage (TTA) in Hubei Province, China. The surrounding rock and concrete anchorage body were simulated by 8 nodes 3D brick elements. The geostatic state of the complex geometric structure was established with initial data. The in-situ concrete casting of the anchorage body and excavation of the rock mass were simulated by tetrahedral shell elements. The results show that the surrounding rock is in an elastic state under the designed cable force. The numerical overloading analysis indicates that the capacity of the surrounding anchorage is 7 times that of the designed cable force. The failure pattern shows that two anchorage bodies would be pulled out in the end. The maximum shear stress appears 10 m before the back anchorage face. The maximum range influenced by the TTA under ultimate loads is about 16 m.

  18. Intrusion of overerupted molars by corticotomy and orthodontic skeletal anchorage.

    Science.gov (United States)

    Moon, Cheol-Hyun; Wee, Jin-Uk; Lee, Hyun-Sun

    2007-11-01

    This article describes the orthodontic treatment of a 26-year-old female patient with overerupted left maxillary molar teeth. Her chief complaint was that the maxillary left first and the second molar intruded into the space required for the mandibular left first and the second molars, preventing prosthodontic treatment. The authors performed a corticotomy and used orthodontic skeletal anchorage with a miniplate and orthodontic miniscrews with a head modified to provide a specially designed hook. With this approach, they were able to achieve a sufficient amount of molar intrusion without discomfort, root resorption, or extrusion of the adjacent teeth. The first molar was intruded 3.0 mm and second molar was intruded 3.5 mm during 2 months of treatment. These results have been maintained for 11 months. PMID:18004918

  19. Exterior beam-column joint study with non-conventional reinforcement detailing using mechanical anchorage under reversal loading

    Indian Academy of Sciences (India)

    S Rajagopal; S Prabavathy

    2014-10-01

    Reinforced concrete structures beam-column joints are the most critical regions in seismic prone areas. Proper reinforcement anchorage is essential to enhance the performance of the joints. An attempt has been made to appraise the performance of the anchorages and joints. The anchorages are detailed as per ACI-352 (mechanical anchorages), ACI-318 (conventional bent hooks) and IS-456 (conventional full anchorage). The joints are detailed without confinement in group-I and with additional X-cross bar in group-II. To assess the seismic performance, the specimens are assembled into two groups of three specimens each and were tested under reversal loading, The specimen with T-type mechanical anchorage (Headed bar) and T-type mechanical anchorage combination with X-cross bar exhibited significant improvement in seismic performance: load-displacement capacity, displacement ductility, stiffness degradation, controlled crack capacity in the joint shear panel and also reduced congestion of reinforcement in joint core.

  20. Thick-Walled Cylinder Theory Applied on a Conical Wedge Anchorage

    DEFF Research Database (Denmark)

    Bennitz, Anders; Grip, Niklas; Schmidt, Jacob Wittrup

    2011-01-01

    Conical wedge anchorages are frequently used to anchor steel tendons in prestressing applications within the construction industry. To replace the steel tendons with non-corrosive and low weight FRPs (Fiber Reinforced Polymers), the different mechanical interactions between the steel and FRPs call...... for further development of the anchorage.In this paper, we derive and examine an analytical model for the internal stresses and strains within the anchorage for a prescribed presetting distance. This model is derived from the theory of thick walled cylinders under the assumptions regarding plane...

  1. Anchorage Failure of RC beams strengthened with FRP at the bottom face

    DEFF Research Database (Denmark)

    Täljsten, Björn; Arifovic, Fedja

    2009-01-01

    When RC beams are strengthened by FRP plates bonded to the bottom face of the beam they fail due to the lack of the mechanical anchorage of the plate. This paper shows that it is possible to relate the anchorage failure of tension face FRP-plated beams to the crack sliding capacity of the beams...... load of tension face plated beams. The assumption is that the FRP-plate must be extended at least one critical anchorage length beyond the theoretical occurrence of the critical diagonal crack....

  2. Urban contaminants project: Data for sediment, fish and eggs collected from Chester Creek, Anchorage, Alaska 1991

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Urbanization has degraded the water quality and adversely impacted biological communities in the lakes and streams of Anchorage. Pollution from point and nonpoint...

  3. Calculation of absorbed dose of anchorage-dependent cells from internal beta-rays irradiation

    International Nuclear Information System (INIS)

    Objective: To elicit the formula of internal dosimetry in anchorage-dependent cells by beta-emitting radionuclides from uniformly distributed volume sources. Methods: By means of the definition of absorbed dose and the MIRD (Medical International Radiation Dose) scheme the formula of internal dosimetry was reasonably deduced. Firstly, studying the systems of suspension culture cells. Then, taking account of the speciality of the systems of the anchorage-dependent cells and the directions of irradiation, the absorbed dose of anchorage -dependent cells was calculated by the accumulated radioactivity, beta-ray energy, and the volume of the cultured systems. Results: The formula of internal dosimetry of suspension culture cells and anchorage-dependent cells were achieved. At the same time, the formula of internal dosimetry of suspension culture cells was compared with that of MIRD and was confirmed accurate. Conclusion: The formula of internal dosimetry is concise, reliable and accurate

  4. CFRP筋复合型锚具锚固性能研究%Research on Anchorage Performance of Wedge-bond Anchorage for CFRP Tendons

    Institute of Scientific and Technical Information of China (English)

    刘荣桂; 刘德鑫; 延永东

    2013-01-01

    In order to solve the anchorage problems for carbon fiber reinforced polymer (CFRP) tendons,a wedge-bond anchorage for CFRP tendons was developed.This anchorage consisted of bonding material,metal sleeve,clip and conical barrel.Influence factors of anchorage performance,such as length of clip,length of metal sleeve,clip clamping position and bonding material were illustrated.Results show that bonding material,length of metal sleeve,and clip clamping position will have significant influence on anchorage performance.The clip clamping position should be avoided at both ends of the metal sleeve,and should make compression zone metal sleeve length be less than that of the tension zone length.Meanwhile,the anchorage performance of bonding material Lica-B is better than that of bonding material Lica-A.The each component of wedge-bond anchorage has good cooperative work performance,and there is no relative slip between clip and metal sleeve.The wedge-bond anchorage with reasonable parameters can anchor CFRP tendons with diameter of 8 mm effectively.%为解决碳纤维增强复合材料(CFRP)筋的锚固问题,研制了由粘结材料、金属筒、夹片和锚环组成的CFRP筋复合型锚具,并进行了夹片长度、金属筒长度、夹片夹持位置以及粘结材料对CFRP筋复合型锚具的锚固性能影响试验.结果表明:粘结材料、金属筒长度和夹片夹持位置均对锚固性能有较大影响;夹片的夹持位置应避免在金属筒两端,且宜使金属筒受压区长度小于受拉区长度;Lica-B型粘结材料锚固性能优于Lica-A型粘结材料;复合型锚具各组件协同工作性能良好,夹片与金属筒间无滑移产生;参数合理的该类复合型锚具可有效锚固直径为8 mm的CFRP筋.

  5. Mechanical properties and failure characteristics of fractured sandstone with grouting and anchorage

    Institute of Scientific and Technical Information of China (English)

    Zong Yijiang; Han Lijun; Qu Tao; Yang Shengqi

    2014-01-01

    Based on uniaxial compression experimental results on fractured sandstone with grouting and anchorage, we studied the strength and deformation properties, the failure model, crack formation and evolution laws of fractured sandstone under different conditions of anchorage. The experimental results show that the strength and elastic modulus of fractured sandstone with different fracture angles are sig-nificantly lower than those of intact sandstone. Compared with the fractured samples without anchorage, the peak strength, residual strength, peak and ultimate axial strain of fractured sandstone under different anchorage increase by 64.5-320.0%, 62.8-493.0%, and 31.6-181.4%, respectively. The number of bolts and degree of pre-stress has certain effects on the peak strength and failure model of fractured sandstone. The peak strength of fractured sandstone under different anchorage increases to some extent, and the failure model of fractured sandstone also transforms from tensile failure to tensile-shear mixed failure with the number of bolts. The pre-stress can restrain the formation and evolution process of tensile cracks, delay the failure process of fractured sandstone under anchorage and impel the transformation of failure model from brittle failure to plastic failure.

  6. Transfer and anchorage bond behaviour in self-compacting concrete

    Directory of Open Access Journals (Sweden)

    Rigueira-Víctor, J. W.

    2006-12-01

    Full Text Available Self-compacting concretes (SCC provide solutions to the problems facing precast concrete construction, enhancing competitiveness, reducing turnaround times and improving final product quality. SCC is fast becoming a key product for the future development of the precast pre-stressed concrete industry.The present paper compares the bond performance of SCC and traditional concrete (TC. The bond performance results confirm the viability of SCC in precast pre-stressed concrete manufacture, despite a slightly higher loss of pre-stressing force and slightly greater anchorage lengths in SCC with a low water/cement ratio. No differences in transfer or anchorage length were detected,however, when high strength TC and SCC were compared. The ECADA test method proved to be well suited to detecting the differences between the concretes analyzed.El desarrollo de los hormigones autocompactantes (SCCofrece muchas posibilidades a las construcciones con hormigón prefabricado, aumentando su competitividad, reduciéndolos plazos de fabricación y ofreciendo mejoras en la calidad del producto final. El SCC se está convirtiendo en un producto clave para el futuro desarrollo de la industria de prefabricados de hormigón pretensado.En este estudio se compara el comportamiento adherente de los SCC con el de los hormigones tradicionales (TC actuales. Los resultados obtenidos confirman la viabilidad del uso de los SCC para la fabricación de elementos prefabricados con hormigón pretensado, en lo relativo a su comportamiento adherente, aunque con la necesidad de considerar unas pérdidas de pretensado ligeramente mayores. Asimismo,debe esperarse un ligero aumento de las longitudes de anclaje cuando se trabaje con SCC de baja relación agua/cemento. Sin embargo, no se han detectado diferencias de comportamiento entre ambos tipos de hormigón cuando la resistencia a compresión es alta en lo relativo a las longitudes de transmisión y anclaje. El método de ensayo ECADA

  7. Guidelines for evaluation of anchorage adequacy for safety-related equipment typically used on WWER-type NPPs

    International Nuclear Information System (INIS)

    This report describes the criteria which should be met when the capacity evaluation of anchorage of safety related equipment is performed for the WWER type NPPs. It should be noted that these criteria were developed specifically for anchorage of WWER type equipment and components to the concrete or steel building structures and they cover different types of anchor bolts and other anchorage details which are typical just for the existing, constructed or reconstructed WWER type NPPs. The screening approach for verifying of equipment anchorage presented in this report is based on a combination of inspections, calculations, and engineering judgement

  8. Experiment on Anchorage Performance of Bond-type Anchorage for CFRP Tendon%CFRP筋粘结式锚具锚固性能试验

    Institute of Scientific and Technical Information of China (English)

    蒋田勇; 方志

    2011-01-01

    针对碳纤维增强塑料(CFRP)作为预应力筋或拉索时出现的锚固问题,开发了一种以活性粉末混凝土(RPC)作为粘结介质的粘结式锚具.建立了平均粘结强度及其对应的滑移量、临界锚固长度以及粘结滑移本构模型等计算公式.通过静载试验研究了筋材表面形状、锚固长度、根数、间距、套筒内壁倾角以及筋材预张拉等对锚固性能的影响.结果表明:CFRP筋的表面形状对以RPC作为粘结介质的粘结式锚具的锚固性能有着决定性影响;当表面压纹CFRP筋的抗拉强度不大于3 000 MPa,RPC抗压强度不小于130 MPa时,对于普通粘结试件,临界锚团长度为20倍筋材直径;对于预张拉粘结试件,当预张比为56%时,锚固系统具有最短的临界锚固长度为13倍筋材直径;多筋同时锚固时,其间距不宜小于1倍筋材直径.%Aimed at anchorage problems that carbon fiber reinforced polymer/plastics (CFRP)was used as prestress tendon and cable reactive powder concrete (RPC) was regarded as bond medium and based on it, a new bond-type anchorage was developed.The calculated formulas of average bond strength and its corresponding slip, critical anchorage length, and bond-slip constitutive model were proposed.Influences of surface shape, bond length, number and space of CFRP tendons, slope angle of inner wall of steel sleeve and pretensioning load on anchorage performance were studied by static test.Test results show that the surface shape of CFRP tendon is significant to the anchorage performance of the bond-type anchorage.When the tensile strength of the indented surface CFRP tendon is less than 3 000 MPa and compressive strength of RPC is more than 130 MPa, the critical anchorage length is 20 diameters of general CFRP tendon for common bond specimen, the shortest critical anchorage length in anchorage system is 13 diameters of pretensioning CFRP tendon with ratio of 56 % of pretensioning load.The appropriate rod space is

  9. Experimental study and stress analysis of rock bolt anchorage performance

    Directory of Open Access Journals (Sweden)

    Yu Chen

    2014-10-01

    Full Text Available A new method was developed to apply pull-and-shear loads to the bolt specimen in order to evaluate the anchorage performance of the rebar bolt and the D-Bolt. In the tests, five displacing angles (0°, 20°, 40°, 60°, and 90°, two joint gaps (0 mm and 30 mm, and three kinds of host rock materials (weak concrete, strong concrete, and concrete-granite were considered, and stress–strain measurements were conducted. Results show that the ultimate loads of both the D-Bolt and the rebar bolt remained constant with any displacing angles. The ultimate displacement of the D-Bolt changed from 140 mm at the 0° displacing angle (pure pull to approximately 70 mm at a displacing angle greater than 40°. The displacement capacity of the D-Bolt is approximately 3.5 times that of the rebar bolt under pure pull and 50% higher than that of the rebar bolt under pure shear. The compressive stress exists at 50 mm from the bolt head, and the maximum bending moment value rises with the increasing displacing angle. The rebar bolt mobilises greater applied load than the D-Bolt when subjected to the maximum bending. The yielding length (at 0° of the D-Bolt is longer than that of the rebar bolt. The displacement capacity of the bolts increased with the joint gap. The bolt subjected to joint gap effect yields more quickly with greater bending moment and smaller applied load. The displacement capacities of the D-Bolt and the rebar bolt are greater in the weak host rock than that in the hard host rock. In pure shear condition, the ultimate load of the bolts slightly decreases in the hard rock. The yielding speed in the hard rock is higher than that in the weak rock.

  10. Experimental study and stress analysis of rock bolt anchorage performance

    Institute of Scientific and Technical Information of China (English)

    Yu Chen

    2014-01-01

    A new method was developed to apply pull-and-shear loads to the bolt specimen in order to evaluate the anchorage performance of the rebar bolt and the D-Bolt. In the tests, five displacing angles (0?, 20?, 40?, 60?, and 90?), two joint gaps (0 mm and 30 mm), and three kinds of host rock materials (weak concrete, strong concrete, and concrete-granite) were considered, and stressestrain measurements were con-ducted. Results show that the ultimate loads of both the D-Bolt and the rebar bolt remained constant with any displacing angles. The ultimate displacement of the D-Bolt changed from 140 mm at the 0? displacing angle (pure pull) to approximately 70 mm at a displacing angle greater than 40?. The displacement capacity of the D-Bolt is approximately 3.5 times that of the rebar bolt under pure pull and 50%higher than that of the rebar bolt under pure shear. The compressive stress exists at 50 mm from the bolt head, and the maximum bending moment value rises with the increasing displacing angle. The rebar bolt mobilises greater applied load than the D-Bolt when subjected to the maximum bending. The yielding length (at 0?) of the D-Bolt is longer than that of the rebar bolt. The displacement capacity of the bolts increased with the joint gap. The bolt subjected to joint gap effect yields more quickly with greater bending moment and smaller applied load. The displacement capacities of the D-Bolt and the rebar bolt are greater in the weak host rock than that in the hard host rock. In pure shear condition, the ultimate load of the bolts slightly decreases in the hard rock. The yielding speed in the hard rock is higher than that in the weak rock.

  11. Bolt Pull-Out Tests of Anchorage Body under Different Loading Rates

    Directory of Open Access Journals (Sweden)

    Tong-bin Zhao

    2015-01-01

    Full Text Available Based on the force analysis and mechanical transmission mechanism of grouting bolts, the self-developed test apparatus for interfacial mechanics is used to study the distribution rule of axial force and interfacial stress of bolts in anchorage body. At the same time, pull-out tests of anchorage body are simulated with the particle flow code software PFC2D, and stress distribution and failure patters are researched under different loading rates. The results show that the distribution of axial force and interfacial shear stress is nonuniform along the anchorage section: axial force decreases, shear force increases first and then decreases, and the maximum value of both of them is closed to the pull-out side; with the increase of loading rates, both of axial force and interfacial shear stress show a trend of increase in the upper anchorage section but changes are not obvious in the lower anchorage section, which causes serious stress concentration; failure strength of pull-out and loading rates show a linear correlation; according to loading rates’ impact on the anchoring effect, the loading rates’ scope can be divided into soft scope (v100 mm/s.

  12. The Influence of CFRP Anchorage on Achieving Sectional Flexural Capacity of Strengthened Concrete Beams

    Directory of Open Access Journals (Sweden)

    Hayder A. Rasheed

    2015-12-01

    Full Text Available This research program is intended to verify the influence of using distributed external U-wrap CFRP anchorage to shift the failure mode from overall debonding to sectional flexural failure for concrete beams externally bonded with CFRP sheets. Premature cover delamination and FRP debonding are predominant failure modes in FRP flexural strengthening that may be delayed or prevented by using FRP anchorage. The present experimental study aims to comparatively prove that proper anchorage of flexural strengthening is anticipated to yield a classical flexural failure by FRP rupture or concrete crushing. Once the cohesion of concrete and/or the adhesion with the FRP is exhausted, the U-wraps are engaged to provide anchorage to the flexural FRP through shear friction. Accordingly, three identical T beams and three identical rectangular beams were designed and constructed to examine the capacity improvement by preventing premature debonding failure. The first specimen in each series was tested as a control beam. The second specimen in each series was strengthened using five layers of flexural CFRP in order to admit a debonding failure. The third specimen in each series was strengthened with the same five layers of flexural CFRP plus additional transverse CFRP U-wraps. This study proved that it is possible to quantify the higher flexural capacity of CFRP strengthened beams using external anchorage.

  13. Ground Water in the Anchorage Area, Alaska--Meeting the Challenges of Ground-Water Sustainability

    Science.gov (United States)

    Moran, Edward H.; Galloway, Devin L.

    2006-01-01

    Ground water is an important component of Anchorage's water supply. During the 1970s and early 80s when ground water extracted from aquifers near Ship Creek was the principal source of supply, area-wide declines in ground-water levels resulted in near record low streamflows in Ship Creek. Since the importation of Eklutna Lake water in the late 1980s, ground-water use has been reduced and ground water has contributed 14-30 percent of the annual supply. As Anchorage grows, given the current constraints on the Eklutna Lake water availability, the increasing demand for water could place an increasing reliance on local ground-water resources. The sustainability of Anchorage's ground-water resources challenges stakeholders to develop a comprehensive water-resources management strategy.

  14. Numerical Simulation and Experimental Validation of an Integrated Sleeve-Wedge Anchorage for CFRP Rods

    DEFF Research Database (Denmark)

    Schmidt, Jacob Wittrup; Smith, Scott T.; Täljsten, Björn; Bennitz, Anders; Goltermann, Per; Pedersen, Henning

    2011-01-01

    The tensioning of carbon fibre-reinforced polymer (CFRP) rods for prestressed concrete applications or post-tensioning repair and strengthening has met with mixed success. This is primarily due to limitations inherent in the use of traditional wedge anchors typically used for steel tendons....... Recently, an integrated sleeve-wedge anchorage has been successfully developed specifically for CFRP rods. This paper in turn presents a numerical simulation of the newly developed anchorage using ABAQUS. The three-dimensional finite element (FE) model, which considers material non-linearity, uses...... hexagonal elements for the barrel and CFRP rod and tetrahedral elements for the integrated sleeve-wedge. The simulated barrel surface strains are shown to compare well with optically measured strains, however, the numerical results are shown to be sensitive to the mechanical properties of the anchorage and...

  15. 33 CFR 165.556 - Regulated Navigation Area; Chesapeake and Delaware Canal, Chesapeake City Anchorage Basin, MD.

    Science.gov (United States)

    2010-07-01

    ... areas, found in 33 CFR 165.13, apply to the regulated navigation area described in paragraph (a) of this...; Chesapeake and Delaware Canal, Chesapeake City Anchorage Basin, MD. 165.556 Section 165.556 Navigation and..., Chesapeake City Anchorage Basin, MD. (a) Location. The following area is a regulated navigation area:...

  16. Three dimensional finite element analysis of rapid maxillary expansion using implant anchorage

    International Nuclear Information System (INIS)

    Objective: To evaluate the biomechanical effect of rapid maxillary expansion(RME) with different anchorages at the same load conditions in a three-dimensional finite element model, and provide a theoretical basis for clinical application. Methods: Three-dimensional finite element model of maxilla was made. In the model 1, natural teeth were used as the anchorage; in the model 2, both the teeth and the implant were used as the anchorage. Force 20 N in the Horizontal direction was loaded on model 1 and model 2, respectively, and the displacement on the X-axis, Y-axis and Z-axis were calculated. Then the stress distribution on the bone and the teeth were evaluated, and the displacement trend was depicted. Results: Both the two models showed that on the cross-section the median palatine suture opened larger at the front, and on the coronal section the median palatine suture opened like a triangle with its base downward. The cown of the tooth shifted buccally while its root shifted lingually. The displacement in model 2 showed less than that in model 1, and the stress in model 2 was also lower than that in model 1. Conclusion: Compared with the natural teeth, using an implant as an anchorage can increase the bone effect while reduce the tooth effect. (authors)

  17. Management of post midface distraction occlusal discrepancy using temporary anchorage devices in a cleft patient

    OpenAIRE

    Koteswara Prasad, N. K.; Syed Altaf Hussain; Chitharanjan, Arun B; Jyotsna Murthy

    2015-01-01

    Open bite deformity following a successful midface advancement by distraction osteogenesis is a common complication. Temporary anchorage devices can be deployed during the distraction and post-distraction settling phases for restoring the occlusion even in severe cases. The following report describes the management of severe anterior open bite following maxillary distraction.

  18. Evaluating School Wellness Policy in Curbing Childhood Obesity in Anchorage, Alaska

    Science.gov (United States)

    Parsons, Wendy G.; Garcia, Gabriel M.; Hoffman, Pamela K.

    2014-01-01

    In 2006, the Anchorage School District implemented a school wellness policy to address the problem of obesity among its elementary-aged students. We assessed whether the addition of this policy is effective in protecting or preventing students from becoming overweight/obese over time. The methods involved following two cohorts of students for 5…

  19. Characterization of ambient fine particles in the northwestern area and Anchorage, Alaska.

    Science.gov (United States)

    Kim, Eugene; Hopke, Philip K

    2008-10-01

    Ambient PM2.5 (particulate matter less than 2.5 microm in aerodynamic diameter) in the northwestern United States and Alaska is dominated by carbonaceous compounds associated with wood burning and transportation sources. PM2.5 source characterization studies analyzing recent PM2.5 speciation data have not been previously reported for these areas. In this study, ambient PM2.5 speciation samples collected at two monitoring sites located in the northwestern area, Olympic Peninsula, WA, and Portland, OR, and one monitoring site located in Anchorage, AK, were characterized through source apportionments. Gasoline vehicle, secondary sulfate, and wood smoke were the largest sources of PM2.5 collected at the Anchorage, Olympic, and Portland monitoring sites, respectively. Secondary sulfates showed an April peak at Anchorage and a November peak at Portland that are likely related to the increased photochemical reaction and long-range transport in Anchorage and meteorological stagnation in Portland. Secondary nitrate at the Olympic site showed a weak summer high peak that could be caused by seasonal tourism in the national park. Backward trajectories suggested that the elevated aged sea salt concentrations at the Portland monitoring site could be regional transport of sea salt that passed through other contaminated air sheds along the coast. Oil combustion emissions that might originate from ships and ferries were observed at the Olympic monitoring site. PMID:18939780

  20. Anchorage of machined and TPS-coated dental implants of various lengths: An in vivo study in the dog maxilla

    OpenAIRE

    Carrel, Jean-Pierre; Szmukler-Moncler, Serge; Bernard, Jean-Pierre; Belser, Urs Christophe; Vazquez, Lydia

    2013-01-01

    The use of short implants is nowadays frequent in daily practice. The objective of this experimental study was to test the correlation between extremely different implant surfaces and the anchorage of short implants

  1. Application of a New Anchorage towards the Flexural Strengthening of RC Rectangular Beams with External Steel Tendons

    Directory of Open Access Journals (Sweden)

    Sungnam Hong

    2016-04-01

    Full Text Available To strengthen concrete beams, a new anchorage was proposed, and its performance was evaluated in this study. Seven concrete beams were manufactured and flexurally loaded with displacement control up to the failure point. As important test variables, the anchorage type (new/conventional and the prestress levels in the steel rebar (0, 50, and 100 kN were selected. To investigate the strengthening effects based on these test variables, the deflection, strain, and failure mode were recorded, and then the load, ductility index, and energy ratio were analyzed. Test results showed that the newly proposed end anchorage had better strengthening effects and a greater inelastic energy than the conventional end anchorages.

  2. The human leukemia oncogene bcr-abl abrogates the anchorage requirement but not the growth factor requirement for proliferation.

    OpenAIRE

    Renshaw, M W; McWhirter, J R; Wang, J Y

    1995-01-01

    Proliferation of normal cells in a multicellular organism requires not only growth factors but also the proper attachment to the extracellular matrix. A hallmark of neoplastic transformation is the loss of anchorage dependence which usually accompanies the loss of growth factor requirement. The Bcr-Abl tyrosine kinase of human leukemias is shown here to abrogate only the anchorage, not the growth factor, requirement. Bcr-Abl-transformed cells grow in soft agar but do not proliferate in serum-...

  3. Anchorage onto deciduous teeth: effectiveness of early rapid maxillary expansion in increasing dental arch dimension and improving anterior crowding

    OpenAIRE

    Mutinelli, Sabrina; Manfredi, Mario; Guiducci, Antonio; Denotti, Gloria; Cozzani, Mauro

    2015-01-01

    Background Anchorage onto permanent dentition is a common procedure in rapid maxillary expansion. However, replacing first permanent molars with the second deciduous molars seems to be an option to reduce some negative side effects during orthodontic treatment. The purpose of this study was to evaluate the dental effect of rapid maxillary expansion with anchorage exclusively onto deciduous teeth performed in the first period of transition. Methods Twenty patients with a lateral cross-bite tre...

  4. Inclusion of CFRP-Epoxy Composite for End Anchorage in NSM-Epoxy Strengthened Beams

    Directory of Open Access Journals (Sweden)

    Md. Akter Hosen

    2015-01-01

    Full Text Available Nowadays, the use of near surface mounted (NSM technique strengthening reinforced concrete (RC structural members is going very popular. The failure modes of NSM strengthened reinforced concrete (RC beams have been shown to be largely due to premature failure such as concrete cover separation. In this study, CFRP U-wrap end anchorage with CFRP fabrics was used to eliminate the concrete cover separation failure. A total of eight RC rectangular beam specimens of 125 mm width, 250 mm depth, and 2300 mm length were tested. One specimen was kept unstrengthened as a reference; three specimens were strengthened with NSM steel bars and the remaining four specimens were strengthened with NSM steel bars together with the U-wrap end anchorage. The experimental results showed that wrapped strengthened beams had higher flexural strength and superior ductility performance. The results also show that these beams had less deflection, strain, crack width, and spacing.

  5. Numerical implementation of multiple peeling theory and its application to spider web anchorages

    OpenAIRE

    Brely, L.; Bosia, F.; Pugno, N. M.

    2015-01-01

    Adhesion of spider web anchorages has been studied in recent years, including the specific functionalities achieved through different architectures. To better understand the delamination mechanisms of these and other biological or artificial fibrillar adhesives, and how their adhesion can be optimized, we develop a novel numerical model to simulate the multiple peeling of structures with arbitrary branching and adhesion angles, including complex architectures. The numerical model is based on ...

  6. Aiolos Promotes Anchorage Independence by Silencing p66Shc Transcription in Cancer Cells

    OpenAIRE

    Li, Xichuan; Xu, Zhao; Du, Wei; Zhang, Zhenfa; Wei, Yiliang; Wang, Hao; Zhu, Zhiyan; Qin, Litao; Wang, Lin; Niu, Qing; Zhao, Xiulan; Girard, Luc; Gong, Yimei; Ma, Zhenyi; Sun, Baocun

    2014-01-01

    Anchorage of tissue cells to their physical environment is an obligate requirement for survival which is lost in mature hematopoietic and in transformed epithelial cells. Here we find that a lymphocyte lineage-restricted transcription factor, Aiolos, is frequently expressed in lung cancers and predicts markedly reduced patient survival. Aiolos decreases expression of a large set of adhesion-related genes, disrupting cell-cell and cell-matrix interactions. Aiolos also reconfigures chromatin st...

  7. Comparative evaluation of sagittal anchorage loss in lingual and labial appliances during space closure: A pilot study

    Directory of Open Access Journals (Sweden)

    Shivanand Venkatesh

    2015-01-01

    Full Text Available Aim: The purpose of this investigation was to assess and compare the anchorage loss between labial and lingual appliance systems during space closure. Materials and Methods: Twenty subjects were part of the study among which 10 subjects (mean age 21 ± 3.6 years were treated using lingual appliance system (0.018" slot-STb™ and 10 subjects (mean age 19 ± 6.1 years were treated using labial preadjusted edgewise appliance system (0.018" slot-MBT™ . First premolar extractions were performed to enable retraction of anterior teeth. Lateral cephalometric radiographs were taken at two intervals, before starting space closure and after space closure that were connoted as T0 and T1 and were analyzed using the method described by Pancherz to measure anchorage loss. Intraclass correlation coefficient (ICC was used to evaluate intraexaminer reliability of the measurements. Student′s t-test was performed to verify any statistical significant correlation between the labial and lingual appliance systems. Statistical differences were determined at the 95% confidence level (P < 0.05. Results: The results showed that all ICC for lingual and labial group were ≥0.90 showing good repeatability of the measurements. Mean anchorage loss of 1.238 ± 0.17 mm in lingual appliance system and an anchorage loss of 2.06 ± 0.39 mm occurred with the labial appliance system. On the comparison between the two appliance systems, lingual appliance demonstrated a significantly lesser anchorage loss than did the labial appliance. Interpretation and Conclusion: This prospective study concludes with the fact that lingual appliance provided better anchorage control than labial appliance during space closure. Use of lingual appliance could be considered in critical anchorage cases when compared with labial appliance.

  8. Detection of bond failure in the anchorage zone of reinforced concrete beams via acoustic emission monitoring

    Science.gov (United States)

    Abouhussien, Ahmed A.; Hassan, Assem A. A.

    2016-07-01

    In this study, acoustic emission (AE) monitoring was utilised to identify the onset of bond failure in reinforced concrete beams. Beam anchorage specimens were designed and tested to fail in bond in the anchorage zone. The specimens included four 250 × 250 × 1500 mm beams with four variable bonded lengths (100, 200, 300, and 400 mm). Meanwhile, an additional 250 × 250 × 2440 mm beam, with 200 mm bonded length, was tested to investigate the influence of sensor location on the identification of bond damage. All beams were tested under four-point loading setup and continuously monitored using three distributed AE sensors. These attached sensors were exploited to record AE signals resulting from both cracking and bond deterioration until failure. The variations in the number of AE hits and cumulative signal strength (CSS) versus test time were evaluated to achieve early detection of crack growth and bar slippage. In addition, AE intensity analysis was performed on signal strength of collected AE signals to develop two additional parameters: historic index (H (t)) and severity (S r). The analysis of these AE parameters enabled an early detection of both first cracks (at almost the mid-span of the beam) and bar slip in either of the anchorage zones at the beams’ end before their visual observation, regardless of sensor location. The results also demonstrated a clear correlation between the damage level in terms of crack development/measured free end bar slip and AE parameters (number of hits, CSS, H(t), and S r).

  9. Verification of the local structural response of building structures in the anchorage areas of heavy components

    International Nuclear Information System (INIS)

    In conventional dynamic structural analyses for determining dynamic system response for various locations at which components are installed inside the structures it is common practice (in order to simplify analytical effort) to assume that the anchorage (anchor plate, anchor bolts or throughbolts, concrete and reinforcement in the area of bound) has rigid body characteristics and that the building structure itself does not display any local response of its own. The influence of the stiffness of the anchor plate as well anchor bolts and its stress level on the dynamic response is also neglected. For a large number of anchoring systems, especially for all those components and systems having only a small mass, this assumption is certainly appropriate. At some locations, particularly at points where heavy components are anchored or when loading input has been increased, this can lead to local loading of the anchor system as well as of the building structure well into the nonlinear range. Often, verification of capability to accommodate these loads is not possible without changing the wall thicknesses or increasing the percentage of reinforcement. Since the presence of linear or nonlinear effects can be expected to result in energy dissipation (increase in damping capacity and also a change in the stiffness of the coupled system) it must be assumed that the dynamic response between the theoretical coupling point A and the real connection point B of the component on the anchor plate can be considerably altered. Some changes of the dynamic response in the connection point B have to be expected generally even in cases of linear-elastic loading of the anchorage. Using typical anchoring systems as an example, the influence of consideration of nonlinear effects in the anchorage area of a typical anchor plate on the dynamic response as well as the conservatism of conventional analytical approaches are investigated

  10. Impact of a new gasoline benzene regulation on ambient air pollutants in Anchorage, Alaska

    Science.gov (United States)

    Yano, Yuriko; Morris, Stephen S.; Salerno, Christopher; Schlapia, Anne M.; Stichick, Mathew

    2016-05-01

    The purpose of this study was to quantify the impact of a new U.S. Environmental Protection Agency (EPA) standard that limits the amount of benzene allowed in gasoline on ambient benzene concentrations. This new standard, together with two companion regulations that limit cold-temperature automotive emissions and the permeability of portable fuel containers, was expected to lower the levels of ambient benzene and other volatile organic compounds (VOCs) nationwide. In this study the impact of the gasoline benzene standard was evaluated in Anchorage, Alaska in a two-phase ambient air monitoring study conducted before and after the new gasoline standard was implemented. Gasoline sold by Anchorage retailers was also evaluated in each phase to determine the content of benzene and other gasoline components. The average benzene content in Anchorage gasoline was reduced by 70%, from 5.05% (w/w) to 1.53% (w/w) following the implementation of the standard. The annual mean ambient benzene concentration fell by 51%, from 0.99 ppbv in Phase 1 to 0.49 ppbv in Phase 2. Analysis suggests the change in gasoline benzene content alone reduced benzene emissions by 46%. The changes in toluene, ethylbenzene, and xylene content in gasoline between Phase 1 and 2 were relatively small and the differences in the mean ambient concentrations of these compounds between phases were modest. Our results suggest that cold winter communities in high latitude and mountainous regions may benefit more from the gasoline benzene standard because of high benzene emissions resulting from vehicle cold start and a tendency to develop atmospheric stagnation conditions in the winter.

  11. Corticotomy-assisted molar protraction with the aid of temporary anchorage device.

    Science.gov (United States)

    Uribe, Flavio; Janakiraman, Nandakumar; Fattal, Amine N; Schincaglia, Gian Pietro; Nanda, Ravindra

    2013-11-01

    This case report describes the interdisciplinary management of a 58-year-old woman who was missing lower first molars and supraerupted maxillary first molars. The treatment plan included intrusion of the upper first molars and corticotomy-assisted mandibular second molar protraction with the aid of temporary anchorage devices. Miniscrews were effective in intrusion of the maxillary first molars and protraction of the lower second molars. Although good functional outcome was achieved in 41 months, the corticotomy-assisted procedure did not significantly reduce the treatment time. PMID:23834274

  12. Wind loads analysis at the anchorages of the Talavera de la Reina cable stayed bridge

    Directory of Open Access Journals (Sweden)

    L. Rosa

    2014-06-01

    Full Text Available This paper describes wind tunnel tests performed on wind tunnel models of the Talavera de la Reina cable stayed bridge. The work describes the aeroelastic model construction and it is focused on the evaluation and analysis of the mean and peak wind loads at the tower foundation and the cable anchorages since these data can be very useful by the bridge manufacturer as a support for the bridge design. The work is part of a complete wind tunnel study carried out to analyze the aeroelastic stability of the bridge.

  13. Self-assembled peptide-based hydrogels as scaffolds for anchorage-dependent cells.

    Science.gov (United States)

    Zhou, Mi; Smith, Andrew M; Das, Apurba K; Hodson, Nigel W; Collins, Richard F; Ulijn, Rein V; Gough, Julie E

    2009-05-01

    We report here the design of a biomimetic nanofibrous hydrogel as a 3D-scaffold for anchorage-dependent cells. The peptide-based bioactive hydrogel is formed through molecular self-assembly and the building blocks are a mixture of two aromatic short peptide derivatives: Fmoc-FF (Fluorenylmethoxycarbonyl-diphenylalanine) and Fmoc-RGD (arginine-glycine-aspartate) as the simplest self-assembling moieties reported so far for the construction of small-molecule-based bioactive hydrogels. This hydrogel provides a highly hydrated, stiff and nanofibrous hydrogel network that uniquely presents bioactive ligands at the fibre surface; therefore it mimics certain essential features of the extracellular matrix. The RGD sequence as part of the Fmoc-RGD building block plays a dual role of a structural component and a biological ligand. Spectroscopic and imaging analysis using CD, FTIR, fluorescence, TEM and AFM confirmed that FF and RGD peptide sequences self-assemble into beta-sheets interlocked by pi-pi stacking of the Fmoc groups. This generates the cylindrical nanofibres interwoven within the hydrogel with the presence of RGDs in tunable densities on the fibre surfaces. This rapid gelling material was observed to promote adhesion of encapsulated dermal fibroblasts through specific RGD-integrin binding, with subsequent cell spreading and proliferation; therefore it may offer an economical model scaffold to 3D-culture other anchorage-dependent cells for in-vitro tissue regeneration. PMID:19201459

  14. 33 CFR 110.236 - Pacific Ocean off Barbers Point, Island of Oahu, Hawaii: Offshore pipeline terminal anchorages.

    Science.gov (United States)

    2010-07-01

    ..., Island of Oahu, Hawaii: Offshore pipeline terminal anchorages. 110.236 Section 110.236 Navigation and... Grounds § 110.236 Pacific Ocean off Barbers Point, Island of Oahu, Hawaii: Offshore pipeline terminal... vessels of over 100 gross tons shall not approach within 1,000 yards at a speed in excess of 6 knots....

  15. 77 FR 66942 - Anchorages; Lower Mississippi River, Above Head of Passes, Convent, LA and Point Pleasant, LA

    Science.gov (United States)

    2012-11-08

    ... would double the available anchorage area in these sections of the river, which is necessary to help accommodate increased vessel volume and improve navigational safety for vessels transiting these river.... SUPPLEMENTARY INFORMATION: Table of Acronyms DHS Department of Homeland Security FR Federal Register NPRM...

  16. "How Will I Sew My Baskets?" Women Vendors, Market Art, and Incipient Political Activism in Anchorage, Alaska

    Science.gov (United States)

    Lee, Molly

    2003-01-01

    In this article the author examines the multifaceted role of the Alaska Federation of Natives crafts fair in the lives of Alaska Native women who have left their home villages and moved into Anchorage, Alaska's largest city. At the same time, this discussion raises broader issues such as the evolving politicization of women traders and the growing…

  17. Orthodontic retreatment using anchorage with miniplate to camouflage a Class III skeletal pattern.

    Science.gov (United States)

    Farret, Marcel Marchiori

    2016-06-01

    This manuscript describes the treatment of a 27-year-old patient who was previously treated with two maxillary first premolar extractions. The patient had skeletal Class III malocclusion, Class III canine relationship, anterior crossbite, and a concave profile. As the patient refused orthognathic surgery, a miniplate was used on the right side of the lower arch as an anchorage unit after the extraction of mandibular first premolars, aiding the retraction of anterior teeth. At the end of treatment, anterior crossbite was corrected, in which first molars and canines were in a Class I relationship, and an excellent intercuspation was reached. Furthermore, patient's profile remarkably improved as a result of mandibular incisor retraction. A 30-month follow-up showed good stability of the results obtained. This case was presented to the Brazilian Board of Orthodontics and Dentofacial Orthopedics (BBO) as one of the requirements to become diplomate by the BBO. PMID:27409659

  18. Association of ultraviolet-induced retrovirus expression with anchorage-independent survival in rat embryo cells

    International Nuclear Information System (INIS)

    The authors have shown in the AI assay that the nontransforming retrovirus increases the differential in enhanced survival response in infected cultures. To more fully understand this aspect of the system, they examined the effect of UV irradiation on infected and uninfected FRE cells. In this communication the authors report that UV irradiation induces AI survival in infected and uninfected cells;in uninfected cells there is a concomitant induction of endogenous retrovirus expression. The AI survival of both cell lines was determined using a previously described procedure. Anchorage-dependent media control and solvent control cells, when suspended in medium above an agar base layer, showed a rapid decline in cell survival;however, cells that had been treated with carcinogen did not undergo the destructive process that took place in control cells, indicating specificity

  19. Bio-cultural anchorage of the prickly pear cactus in Tlalnepantla (Morelos, Mexico

    Directory of Open Access Journals (Sweden)

    Torres-Salcido, Gerardo

    2016-06-01

    Full Text Available The prickly pear cactus is a source of food with strong bio-cultural anchorage in Mexico. This is due to at least three factors: 1 the nature and heritage of cacti; 2 cultural heritage; and 3 the socio-cultural relationships with historical and symbolic roots that have facilitated knowledge of how to cultivate it and how to use it. The aim of this article is to put factors of territorial anchorage and its historical transformation in context by examining the case of the municipality of Tlalnepantla in the state of Morelos, Mexico. This community has experienced accelerated change due to the exchange of traditional crops for the prickly pear cactus and the integration of farming, commercialization and agro-transformation. Our hypothesis is that the market, internal conflicts and a lack of socio-institutional coordination have put social organization into crisis, favoring the territorial spread of the prickly pear cactus and making the Local Agro-Food Systems (LAFS of Tlalnepantla less competitive. The conclusions highlight important economic and social advances whose roots lie in the strengthening and anchorage of the territory-product. However, circumstances both internal and external to the community persist, such as intra-community conflicts, the international market and cultural paradigm shifts that affect the producers and put consolidation of the LAFS at risk.El nopal es un alimento con un fuerte anclaje bio-cultural en México, propiciado por al menos tres factores: 1 la naturaleza y el patrimonio de cactáceas; 2 el patrimonio cultural; y, 3 las relaciones socio-culturales que han permitido un “saber hacer” y un “saber utilizar” con raíces históricas y simbólicas. El objetivo es situar los factores de anclaje territorial y su transformación histórica tomando como caso el municipio de Tlalnepantla, en el estado de Morelos, México. Esta comunidad ha experimentado un acelerado cambio por la reconversión de los cultivos

  20. The U.S. Department of Energy Office of Indian Energy Policy and Programs, Anchorage, Alaska, Roundtable Summary

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2011-04-14

    The Anchorage, Alaska Roundtable on Tribal Energy Policy convened at 10:00 a.m., Thursday April 15th, at the downtown Anchorage Hilton. The meeting was held by the Department of Energy (DOE) Office of Indian Energy Policy and Programs (Office of Indian Energy). Tracey LeBeau, Director of the Office of Indian Energy, and Pilar Thomas, Deputy Director-Policy of the Office of Indian Energy, represented DOE. Approximately twenty-seven people attended the meeting, including representatives of three native Alaskan villages, four Alaskan tribal corporations representing more than 40 tribal governments, as well as representatives from tribal associations and conferences. Interested state, federal, and non-profit representatives also were present. A full list of attendees is at the end of this summary. The meeting was facilitated by the Udall Foundation’s U.S. Institute for Environmental Conflict Resolution (U.S. Institute).  

  1. Transdisciplinary treatment of Class III malocclusion using conventional implant-supported anchorage: 10-year posttreatment follow-up

    Directory of Open Access Journals (Sweden)

    Mariana Roennau Lemos Rinaldi

    2015-06-01

    Full Text Available INTRODUCTION: Combined treatment offers advantages for partially edentulous patients. Conventional implants, used as orthodontic anchorage, enable previous orthodontic movement, which provides appropriate space gain for crown insertion. OBJECTIVE: This case report describes the treatment of a 61-year and 10-month-old patient with negative overjet which made ideal prosthetic rehabilitation impossible, thereby hindering dental and facial esthetics. CASE REPORT: After a diagnostic setup, conventional implants were placed in the upper arch to anchor intrusion and retract anterior teeth. Space gain for lateral incisors was achieved in the lower arch by means of an orthodontic appliance. CONCLUSIONS: Integrated planning combining Orthodontics and Implantology provided successful treatment by means of conventional implant-supported anchorage. The resulting occlusal relationship proved stable after 10 years.

  2. Metallurgical Behavior of Ti-6Al-4V Alloy Mini-Implants as a Temporary Anchorage Device in Orthodontics Applications

    Directory of Open Access Journals (Sweden)

    Mendoza-Bravo Ivan

    2014-01-01

    Full Text Available The application of mini implants as a temporary anchorage device in orthodontics is a new technique that allows the movement of teeth in an efficient and predictable way. Although they have started to be used in Germany, Japan and South Korea, there is still the need to analyze and diffuse the advantages this procedure can offer over the traditional techniques. The objective of this research work was to analyze the integrity of Ti-6Al-4V mini implants temporary employed for 4 months on three patients as an anchorage device. The mini implants were analyzed by means of electron scanning microscopy in order to determine superficial and microstructural changes as well as the interaction with human tissue. Results showed the presence of wear on the thread zone caused during the insertion into the maxilar bone. The adherence of organic tissue was also observed on two mini-implants.

  3. Canine retraction and anchorage loss self-ligating versus conventional brackets: a systematic review and meta-analysis

    OpenAIRE

    Zhou, Qiaozhen; ul Haq, Abdul Azeem Amin; Tian, Liu; Chen, Xiaofeng; Huang, Kui; Zhou, Yu

    2015-01-01

    Background The purpose of this systematic review is to identify and review the orthodontic literature with regards to assessing possible differences in canine retraction rate and the amount of antero-posterior anchorage (AP) loss during maxillary canine retraction, using conventional brackets (CBs) and self-ligating brackets (SLBs). Methods An electronic search without time or language restrictions was undertake in September 2014 in the following electronic databases: The Cochrane Oral Health...

  4. Internal structure of mandible around mandibular molar using computed tomography. Anatomical consideration of molar anchorage in orthodontic treatment

    International Nuclear Information System (INIS)

    For establishment of fine occlusion, facial profile and oral function in orthodontic treatment, molar anchorage in teeth movement is important manner in extracted cases. The aims of this study were to investigate the relationship between facial morphology and internal structure of mandibular body in molar region by computer tomography, and to discuss about molar anchorage in orthodontic treatment. The data for this study were obtained from 35 modern male Japanese skulls (mean age; 27 year-old, ranged from 18 year-old to 47 year-old). Measurement variables were FMA, SN to mandibular plane angle, gonial angle, alveolar breadth, cortical bone thickness of buccal and lingual sides, and the distance between dental root and cortical bone. As a result, alveolar breadth and the distance between dental root and cortical bone were narrow in long facial type, on the contrary, these variables were wide in short facial type. The result suggested that these variables were considered important factors as molar anchorage in extracted cases. (author)

  5. Research on the video detection device in the invisible part of stay cable anchorage system

    Science.gov (United States)

    Cai, Lin; Deng, Nianchun; Xiao, Zexin

    2012-11-01

    The cables in anchorage zone of cable-stayed bridge are hidden within the embedded pipe, which leads to the difficulty for detecting the damage of the cables with visual inspection. We have built a detection device based on high-resolution video capture, realized the distance observing of invisible segment of stay cable and damage detection of outer surface of cable in the small volume. The system mainly consists of optical stents and precision mechanical support device, optical imaging system, lighting source, drived motor control and IP camera video capture system. The principal innovations of the device are ⑴A set of telescope objectives with three different focal lengths are designed and used in different distances of the monitors by means of converter. ⑵Lens system is far separated with lighting system, so that the imaging optical path could effectively avoid the harsh environment which would be in the invisible part of cables. The practice shows that the device not only can collect the clear surveillance video images of outer surface of cable effectively, but also has a broad application prospect in security warning of prestressed structures.

  6. Liquid marbles for high-throughput biological screening of anchorage-dependent cells.

    Science.gov (United States)

    Oliveira, Nuno M; Correia, Clara R; Reis, Rui L; Mano, João F

    2015-01-28

    Stable liquid marbles (LM) are produced by coating liquid droplets with a hydrophobic powder. The used hydrophobic powder is produced by fluorosi-lanization of diatomaceous earth, used before to produce superhydrophobic structures. Here, the use of LM is proposed for high-throughput drug screening on anchorage-dependent cells. To provide the required cell adhesion sites inside the liquid environment of LM, surface-modified poly(l-lactic acid) microparticles are used. A simple method that takes advantage from LM appealing features is presented, such as the ability to inject liquid on LM without disrupting (self-healing ability), and to monitor color changes inside of LM. After promoting cell adhesion, a cytotoxic screening test is performed as a proof of concept. Fe(3+) is used as a model cytotoxic agent and is injected on LM. After incubation, AlamarBlue reagent is injected and used to assess the presence of viable cells, by monitoring color change from blue to red. Color intensity is measured by image processing and the analysis of pictures takes using an ordinary digital camera. The proposed method is fully validated in counterpoint to an MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carbo​xymethoxyphenyl)-2-(4-sulfophenyl)-2H-te​trazolium) colorimetric assay, a well-known method used for the cytotoxicity assessment. PMID:25091700

  7. Research Progress of the Anchorage Control in Orthodontic Treatment%正畸治疗中支抗控制的研究进展

    Institute of Scientific and Technical Information of China (English)

    刘春利; 肖丹娜

    2015-01-01

    正畸治疗中支抗控制至关重要,合理的支抗设计关系到治疗的成败。支抗控制可从支抗加强和支抗节省两方面考虑,并在治疗过程中联合应用。正畸治疗效果需以多维效果评价,为取得优质的治疗效果支抗需根据患者的垂直骨面型、牙颌畸形的类型,在矢状向、垂直向、水平向进行控制。该文就目前常用的加强支抗的方法进行简要概括,同时对新兴加强支抗的设计进行简要总结,并对支抗节省的理念、操作和矫治系统的选择进行综述。%The anchorage control is very important in orthodontic treatment,and good design matters to the success or failure of the treatment.Anchorage control includes two aspects of anchorage strengthening and anchorage saving,which both should be taken into consideration,and joint applied in the process of treat-ment.Effect of orthodontic treatment needs multidimensional performance evaluation,to achieve high quality of treatment,sagittal,vertical,and horizontal control should be done according to patients'vertical bone sur-face type and the type of teeth micromaxillary deformity.Here is to make a review of the common methods to strengthen the anchorage,as well as the emerging of strengthening anchorage design,and the idea of the anchorage saving,and the choices of operational and correctional systems.

  8. Mini-placa como ancoragem ortodôntica: relato de caso Mini screw as orthodontic anchorage: case report

    Directory of Open Access Journals (Sweden)

    André Luiz Zétola

    2005-08-01

    ígida pode ser utilizada com bastante propriedade no tratamento ortodôntico qunado for requerida uma ancoragem máxima.It is needless to say that anchorage control is necessary to a successful orthodontic treatment. Without it, it would be impossible to obtain an ideal occlusion through orthodontic mechanics in the majority of cases. The utilization of rigid devices, originated from face traumatology and implant dentistry principles, to obtain rigid anchorage in orthodontics revolutionized the way of treating cases with an unsatisfactory prognosis. Specially in cases where a lot of anchorage is needed and it is difficult or impossible to get it. The objective of this article was to revise the literature related to the use of mini-screw implant systems, to report a case where it was utilized and to discuss some aspects related to the usage of rigid anchorage orthodontics. The rigid anchorage was used in a 39 year old female patient, who had the upper left molars with a relevant extrusion due to the absence of the lower left molars. Fixed appliances were placed on the upper arch with a TPA connecting the second bicuspids. The TPA was used to anchor the intrusion of the upper left molars. A quad-helix appliance was used to correct the upper right third molar crossbite. Since the orthodontic intrusion with only dental anchorage did not have a satisfactory result, an "L" shaped titanium plate was placed on the maxilla, at the apical region of the upper first and second left molars, with the purpose of obtaining a rigid orthodontic anchorage to intrude them. Elastics were used during five months with intrusive force,the obtained intrusion was 6 millimeters. After the removal of the appliance, upper and lower dental bleaching was made and final prosthesis were placed over the implants. Through the literature reviewed and the case reported, it can be concluded that rigid anchorage can be indicated in orthodontic treatments where there is lack of anchorage or the need of an absolute

  9. Evaluation of the variable anchorage straightwire technique using Ricketts' growth prediction.

    Science.gov (United States)

    Parikakis, Konstantinos A; Moberg, Svante; Hellsing, Eva

    2009-02-01

    The purpose of this retrospective study was to evaluate the treatment effects of the variable anchorage straightwire technique (VAST) in Angle Class II patients using Ricketts' growth prediction analysis. The subjects belonged to two groups: a control, consisting of 30 untreated Class II Swedish individuals (20 girls, 10 boys) with a mean age of 11.2 years, and the other 29 Swedish patients (14 girls, 15 boys), mean age 12.6 years, post-normal and with an increased overbite (OB), treated with the VAST. Two lateral cephalograms were available for every individual. Growth prediction according to Ricketts' visual treatment objective (VTO) was used to estimate the expected growth increments for a 2-year period. It was first used in the control group to determine its validity and then applied to the treated group to evaluate the net effects of treatment. Cephalometric evaluation based on Ricketts' analysis and additional dentoalveolar variables were carried out. Statistical analysis was undertaken using a paired Student's t- and Wilcoxon signed ranks tests. The method of predicting growth according to the VTO was, in general, valid in the untreated subjects, apart from the inclination of the lower incisors, where the proclination had been underestimated. In the treated group, the net effects of treatment were significant for the dentoalveolar variables: reduction of overjet (OJ) and OB, proclination and relative intrusion of the lower incisors, extrusion of the molars, and increase in lower face height. The growth prediction method according to VTO was found to be valid in a sample of Swedish post-normal children concerning skeletal and dentoalveolar variables. The VAST treatment net effects in these growing patients were achieved mainly by dentoalveolar changes. PMID:18832190

  10. A Study of Success Rate of Miniscrew Implants as Temporary Anchorage Devices in Singapore

    Directory of Open Access Journals (Sweden)

    Song Yi Lin

    2015-01-01

    Full Text Available Objective. To find out the success rate of miniscrew implants in the National Dental Centre of Singapore (NDCS and the impact of patient-related, location-related, and miniscrew implant-related factors. Materials and Methods. Two hundred and eighty-five orthodontic miniscrew implants were examined from NDCS patient records. Eleven variables were analysed to see if there is any association with success. Outcome was measured twice, immediately after surgery prior to orthodontic loading (T1 and 12 months after surgery (T2. The outcome at T2 was assessed 12 months after the miniscrew’s insertion date or after its use as a temporary anchorage device has ceased. Results. Overall success rate was 94.7% at T1 and 83.3% at T2. Multivariate analysis revealed only the length of miniscrew implant to be significantly associated with success at both T1 (P=0.002 and T2 (P=0.030. Miniscrew implants with lengths of 10–12 mm had the highest success rate (98.0% compared to other lengths, and this is statistically significant (P=0.035. At T2, lengths of 10–12 mm had significantly (P=0.013 higher success rates (93.5% compared to 6-7 mm (76.7% and 8 mm (82.1% miniscrew implants. Conclusion. Multivariate statistical analyses of 11 variables demonstrate that length of miniscrew implant is significant in determining success.

  11. Protein disulfide isomerases in the endoplasmic reticulum promote anchorage-independent growth of breast cancer cells.

    Science.gov (United States)

    Wise, Randi; Duhachek-Muggy, Sara; Qi, Yue; Zolkiewski, Michal; Zolkiewska, Anna

    2016-06-01

    Metastatic breast cancer cells are exposed to stress of detachment from the extracellular matrix (ECM). Cultured breast cancer cells that survive this stress and are capable of anchorage-independent proliferation form mammospheres. The purpose of this study was to explore a link between mammosphere growth, ECM gene expression, and the protein quality control system in the endoplasmic reticulum (ER). We compared the mRNA and protein levels of ER folding factors in SUM159PT and MCF10DCIS.com breast cancer cells grown as mammospheres versus adherent conditions. Publicly available gene expression data for mammospheres formed by primary breast cancer cells and for circulating tumor cells (CTCs) were analyzed to assess the status of ECM/ER folding factor genes in clinically relevant samples. Knock-down of selected protein disulfide isomerase (PDI) family members was performed to examine their roles in SUM159PT mammosphere growth. We found that cells grown as mammospheres had elevated expression of ECM genes and ER folding quality control genes. CTC gene expression data for an index patient indicated that upregulation of ECM and ER folding factor genes occurred at the time of acquired therapy resistance and disease progression. Knock-down of PDI, ERp44, or ERp57, three members of the PDI family with elevated protein levels in mammospheres, in SUM159PT cells partially inhibited the mammosphere growth. Thus, breast cancer cell survival and growth under detachment conditions require enhanced assistance of the ER protein folding machinery. Targeting ER folding factors, in particular members of the PDI family, may improve the therapeutic outcomes in metastatic breast cancer. PMID:27161215

  12. Combining oxygen plasma treatment with anchorage of cationized gelatin for enhancing cell affinity of poly(lactide-co-glycolide).

    Science.gov (United States)

    Shen, Hong; Hu, Xixue; Yang, Fei; Bei, Jianzhong; Wang, Shenguo

    2007-10-01

    Surface characteristics greatly influence attachment and growth of cells on biomaterials. Although polylactone-type biodegradable polymers have been widely used as scaffold materials for tissue engineering, lack of cell recognition sites, poor hydrophilicity and low surface energy lead to a bad cell affinity of the polymers, which limit the usage of polymers as scaffolds in tissue engineering. In the present study, surface of poly (L-lactide-co-glycolide) (PLGA) was modified by a method of combining oxygen plasma treatment with anchorage of cationized gelatin. Modification effect of the method was compared with other methods of oxygen plasma treatment, cationized gelatin or gelatin coating and combining oxygen plasma treatment with anchorage of gelatin. The change of surface property was compared by contact angles, surface energy, X-ray photoelectron spectra (XPS), attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR) and scanning electron microscopy (SEM) measurement. The optimum oxygen pretreatment time determined by surface energy was 10 min when the power was 50 W and the oxygen pressure was 20 Pa. Analysis of the stability of gelatin and cationized gelatin anchored on PLGA by XPS, ATR-FTIR, contact angles and surface energy measurement indicated the cationized gelatin was more stable than gelatin. The result using mouse NIH 3T3 fibroblasts as model cells to evaluate cell affinity in vitro showed the cationized gelatin-anchored PLGA (OCG-PLGA) was more favorable for cell attachment and growth than oxygen plasma treated PLGA (O-PLGA) and gelatin-anchored PLGA (OG-PLGA). Moreover cell affinity of OCG-PLGA could match that of collagen-anchored PLGA (AC-PLGA). So the surface modification method combining oxygen plasma treatment with anchorage of cationized gelatin provides a universally effective way to enhance cell affinity of polylactone-type biodegradable polymers. PMID:17618682

  13. Moving Toward a Globally Harmonized Volcanic Ash Forecast System: Anchorage and Tokyo VAAC Best Practices on Collaboration

    Science.gov (United States)

    Osiensky, J. M.; Moore, D.; Igarashi, Y.

    2014-12-01

    Since the eruption of Eyjafjallajökull in 2010, there has been an increased awareness on the need for better collaboration between the Volcanic Ash Advisory Centers (VAACs). Work through the International Civil Aviation Organization (ICAO) International Airways Volcano Watch Operations Group (IAVWOPSG) and International Airways Volcano Task Force (IAVTF) brought increased awareness and focus to this challenge. A VAAC Best Practices group was formed out of these larger meetings and focused on VAAC specific issues of importance. Collaboration was one of the topics under consideration. Some ideas and procedures for an effective, yet easy, method for the VAACs to collaborate have been discussed. Implementation has been mainly on a VAAC to VAAC basis, however a more consolidated process needs to be developed and agreed upon between all VAACs in order to successfully move toward harmonization. Collaboration procedures and tools are being considered. The National Weather Service (NWS) Alaska Region has been looking at collaborative software to help the VAACs identify the presence of ash and forecast the plume both in the horizontal and vertical. Having an interactive graphical interface within the forecast operation may help to ensure consistency across VAAC boundaries. Existing chat software within NWS is being investigated to allow Tokyo and Anchorage VAAC to "chat" about forecast issues in real time. This capability is being tested through scenarios. The Anchorage and Tokyo VAACs participated in a series of meetings in Tokyo in March 2014. Collaboration was a major topic of discussion. This paper will outline some of the efforts being undertaken between the Anchorage and Tokyo VAACs as a result of these meetings and subsequent dialogue.

  14. 微种植体初期稳定性的影响因素%Factors affecting primary stability of mini-implant anchorage

    Institute of Scientific and Technical Information of China (English)

    鲁颖娟; 常少海

    2013-01-01

    Mini implant anchorage for the orthodontic treatment is an effective method, the primary stability is critical in the achievement of reliable anchorage. Therefore, it is the purpose of this review to summarize the cur-rent literature on the primary stability of mini-implant anchorage, in order to improve overall implant success.%  微种植体支抗技术是正畸治疗中一种有效和理想的方法,其初期稳定性是获得可靠支抗的必要条件。本文就影响微种植体支抗初期稳定性的患者因素、微种植体因素和操作因素等研究进展作一综述,以提高微种植体支抗的成功率。

  15. [Low-cost simple anchorage systems in the removable hybrid prosthesis. Locator Root Attachment and Würzburg post].

    Science.gov (United States)

    Teubner, Eckart; Galindo, Martha L; Arnold, Dario; Marinello, Carlo P

    2009-01-01

    For a simple and provisional retention of a removable prosthesis, less expensive direct retainers are an option compared to indirect cast gold copings with attachment. The Dalbo-Rotex-retainer and the Ticap-system are clinically established. The Locator Root attachment and the Würzburger Stift were recently introduced. The Locator Root attachment uses a massive profiled cylindrical post as a radicular anchorage. The Würzburger Stift has a small endodontic part which is retained by four spreadable lamellae in a convergent cavity. They further differ in the design of the male and female part. Depending on the clinical situation these characteristics can offer benefits and disadvantages. Both systems are documented and their indication, advantages and restrictions are discussed with clinical relevance. PMID:20112639

  16. Dexamethasone and zinc in combination inhibit the anchorage-independent growth of S-91 Cloudman murine melanoma

    International Nuclear Information System (INIS)

    Zinc inhibited the colony formation of Cloudman S-91 murine melanoma cells in a dose dependent manner with an ID50 of 3.4 μg/ml. Total inhibition of the melanoma colony-forming units occurred at a zinc concentration of 4.42 μg/ml. In the presence of dexamethasone the ID50 for zinc inhibition was reduced by 49% and total inhibition of anchorage-independent growth occurred at the achievable in vivo zinc concentration of 3.0 μg/ml. Dexamethasone and zinc in combination effected a greater than additive inhibition of the murine melanoma colony-forming units. Statistical evaluation of these results showed that zinc and dexamethasone interacted synergistically to inhibit the formation of murine melanoma colonies. 29 references, 1 figure, 1 table

  17. Characterization of the aspects of osteoprogenitor cell interactions with physical tetracalcium phosphate anchorage on titanium implant surfaces

    International Nuclear Information System (INIS)

    Well-designed implants are used not only to modify the geometry of the implant but also to change the chemical properties of its surfaces. The present study aims to assess the biofunctional effects of tetracalcium phosphate (TTCP) particles as a physical anchor on the implant surface derived through sandblasting. The characteristics of the surface, cell viability, and alkaline phosphatase (ALP) activity toward osteoprogenitor cells (D1) were obtained. D1 cells were cultured on a plain surface that underwent sandblasting and acid etching (SLA) (control SLA group) and on different SLA surfaces with different anchoring TTCP rates (new test groups, M and H). The mean anchoring rates were 57% (M) and 74% (H), and the anchored thickness was estimated to range from 12.6 μm to 18.3 μm. Compared with the control SLA surface on Ti substrate, the new test groups with different TTCP anchoring rates (M and H) failed to improve cell proliferation significantly but had a well-differentiated D1 cell phenotype that enhanced ALP expression in the early stage of cell cultures, specifically, at day 7. Results suggest that the SLA surface with anchored TTCP can accelerate progenitor bone cell mineralization. This study shows the potential clinical application of the constructed geometry in TTCP anchorage on Ti for dental implant surface modification. - Highlights: • TTCP (tetracalcium phosphate) as a physical anchorage on implant is characterized. • Theoretical values of anchored thickness and capping areas were estimated. • TTCP anchored by sandblasting can accelerate progenitor bone cell mineralization. • TTCP anchored on SLA (sandblasting and acid etching) surface is a promising method

  18. Characterization of the aspects of osteoprogenitor cell interactions with physical tetracalcium phosphate anchorage on titanium implant surfaces

    Energy Technology Data Exchange (ETDEWEB)

    Ko, Chia-Ling [Advanced Medical Devices and Composites Laboratory, Department of Fiber and Composite Materials, Feng Chia University, Taichung 40724, Taiwan (China); Dental Medical Devices and Materials Research Center, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan (China); Chang, Ya-Yuan; Liou, Cian-Hua [Alliance Global Technology Co., Ltd., Kaohsiung Medical Device Special Zone in Southern Taiwan Science Park, Kaohsiung 82151, Taiwan (China); Chen, Wen-Cheng, E-mail: wencchen@fcu.edu.tw [Advanced Medical Devices and Composites Laboratory, Department of Fiber and Composite Materials, Feng Chia University, Taichung 40724, Taiwan (China)

    2015-04-01

    Well-designed implants are used not only to modify the geometry of the implant but also to change the chemical properties of its surfaces. The present study aims to assess the biofunctional effects of tetracalcium phosphate (TTCP) particles as a physical anchor on the implant surface derived through sandblasting. The characteristics of the surface, cell viability, and alkaline phosphatase (ALP) activity toward osteoprogenitor cells (D1) were obtained. D1 cells were cultured on a plain surface that underwent sandblasting and acid etching (SLA) (control SLA group) and on different SLA surfaces with different anchoring TTCP rates (new test groups, M and H). The mean anchoring rates were 57% (M) and 74% (H), and the anchored thickness was estimated to range from 12.6 μm to 18.3 μm. Compared with the control SLA surface on Ti substrate, the new test groups with different TTCP anchoring rates (M and H) failed to improve cell proliferation significantly but had a well-differentiated D1 cell phenotype that enhanced ALP expression in the early stage of cell cultures, specifically, at day 7. Results suggest that the SLA surface with anchored TTCP can accelerate progenitor bone cell mineralization. This study shows the potential clinical application of the constructed geometry in TTCP anchorage on Ti for dental implant surface modification. - Highlights: • TTCP (tetracalcium phosphate) as a physical anchorage on implant is characterized. • Theoretical values of anchored thickness and capping areas were estimated. • TTCP anchored by sandblasting can accelerate progenitor bone cell mineralization. • TTCP anchored on SLA (sandblasting and acid etching) surface is a promising method.

  19. Mechanical behavior experiment of wedge-bond anchorage for CFRP-tendons%CFRP筋复合型锚具的受力性能试验

    Institute of Scientific and Technical Information of China (English)

    王军; 李明君; 蔡东升; 刘德鑫

    2012-01-01

    In order to investigate the influence of main design parameters on anchorage performance and internal stress distribution of wedge-bond anchorage for CFRP tendons, five groups of parameter tests on wedge-bond anchorage were designed. The ultimate load, slip deformation of anchor ring and stress of metal sleeve stations were determined. The influence of design parameters on anchorage performance, the tress distribution and variation of metal sleeve were contrastively investigated through static loading testing. The results show that the anchorage performance with metal sleeve thickness of 2 mm, a wedge length of 65 mm, bond length of 500 mm is optimal. The anchor between wedge and metal sleeve is good without relative displacement. The tress distribution and variation of metal sleeve can reflect the internal stress distribution of anchorage, and the perk of stress curve indicates bonding failure between colloid and CFRP tendon near the observation point.%为研究CFRP筋复合型锚具的主要设计参数对锚固性能的影响及锚具内部受力情况,设计了5个复合型锚具的参数静载试验,测量了锚具的极限荷载、锚环-CFRP筋间滑移变形和金属筒测点应变,通过静载试验对比分析了各设计参数对锚固效果的影响,以及金属筒表面应力的分布情况与变化规律.研究结果表明:当金属筒壁厚为2 mm,夹片夹持长度为65 mm,粘结长度为500 mm时,锚具的锚固性能较好;夹片-金属筒间锚固良好,无滑移;金属筒应力分布与变化可反映锚具内部受力情况,测点应力曲线峰值预示该位置附近的胶体与CFRP筋间的粘结破坏.

  20. Test instructions for evaluation of the anchorage system of the multiple position borehole extensometers used at the Near-Surface Test Facility

    International Nuclear Information System (INIS)

    The objective of this Post-Test Extensometer evaluation is to ascertain the anchorage ability of the downhole Multiple Position Borehole Extensometer (MPBX) anchors. Tasks to be performed include MPBX Anchor Creep Tests and MPBX Anchor Pull Tests. Information gained from these tests will assist in the evaluation of instrument performance over the period of the Full-Scale Heater Test and provide information to assist in future instrument development. 3 refs., 6 figs

  1. Factors influencing the anchorage strength of welded geogrid in soil%焊接土工格栅土中锚固强度的影响因素

    Institute of Scientific and Technical Information of China (English)

    徐超; 陈洪帅; 朱洪; 朱英俊; 石志龙

    2012-01-01

    A series of pull-out tests of 3 different selected types of welded geogrid buried in coarse grained soils are carried out in the present study. The anchorage strength and its influencing factors are analyzed based on the test results and according to the interaction mechanism of geogrid with soil. The results indicate that for geogrids with the same mesh size, the stronger the peel strength of a geogrid, the higher the anchorage strength in soils. The peel strength of welded geogrid is the controlling index, but not the only influencing factor to the geogrid anchorage strength in soil. The mesh size of georid and the property of soil are also of importance to the development of anchorage strength in soils.%选择3种不同规格的焊接土工格栅,完成了格栅在粗颗粒土中的一系列拉拔试验.根据试验结果和土工格栅与土的相互作用机理,分析了各种格栅在土中的锚固强度及其影响因素.结果表明:在网格尺寸相同的情况下,节点剥离强度越大,则土中锚固强度越高;焊接土工格栅的节点剥离强度是其土中锚固强度的控制指标,但非唯一影响因素,网格尺寸和填土性质也对格栅土中锚固阻力的发挥具有重要影响.

  2. Changes in strain patterns after implantation of a short stem with metaphyseal anchorage compared to a standard stem: an experimental study in synthetic bone

    Directory of Open Access Journals (Sweden)

    Jens Gronewold

    2014-03-01

    Full Text Available Short stem hip arthroplasties with predominantly metaphyseal fixation, such as the METHA® stem (Aesculap, Tuttlingen, Germany, are recommended because they are presumed to allow a more physiologic load transfer and thus a reduction of stress-shielding. However, the hypothesized metaphyseal anchorage associated with the aforementioned benefits still needs to be verified. Therefore, the METHA short stem and the Bicontact® standard stem (Aesculap, Tuttlingen, Germany were tested biomechanically in synthetic femora while strain gauges monitored their corresponding strain patterns. For the METHA stem, the strains in all tested locations including the region of the calcar (87% of the non-implanted femur were similar to conditions of synthetic bone without implanted stem. The Bicontact stem showed approximately the level of strain of the non-implanted femur on the lateral and medial aspect in the proximal diaphysis of the femur. On the anterior and posterior aspect of the proximal metaphysis the strains reached averages of 78% and 87% of the non-implanted femur, respectively. This study revealed primary metaphyseal anchorage of the METHA short stem, as opposed to a metaphyseal-diaphyseal anchorage of the Bicontact stem.

  3. 微种植体支抗在口腔正畸中的应用%Application of mini - implant anchorage in orthodontic treatment

    Institute of Scientific and Technical Information of China (English)

    侯亚男

    2011-01-01

    微种植体作为增强正畸支抗的措施获得了良好的临床效果.微种植体的植入手术简单,可提供绝对支抗,患者舒适感高.本文从微种植体的历史研究背景、作用原理、形态设计影响,植入方式和部位,临床应用,并发症及应用前景等方面进行详尽的综述.%With the rapid development of implant anchorage, the mini - implant has obtained good clinical results as one of the measures to enhance orthodontic anchorage, which has attracted wide attention. The procedure of implantation is simple, and after that the mini - implant can provide absolute anchorage and won't induce uncomfortableness for the patients. In this paper, we reviewed details of background, theory, effects of the design, style and position of the implantation, the clinical applications, the complications and the prospect.

  4. Chlamydia induces anchorage independence in 3T3 cells and detrimental cytological defects in an infection model.

    Directory of Open Access Journals (Sweden)

    Andrea E Knowlton

    Full Text Available Chlamydia are gram negative, obligate intracellular bacterial organisms with different species causing a multitude of infections in both humans and animals. Chlamydia trachomatis is the causative agent of the sexually transmitted infection (STI Chlamydia, the most commonly acquired bacterial STI in the United States. Chlamydial infections have also been epidemiologically linked to cervical cancer in women co-infected with the human papillomavirus (HPV. We have previously shown chlamydial infection results in centrosome amplification and multipolar spindle formation leading to chromosomal instability. Many studies indicate that centrosome abnormalities, spindle defects, and chromosome segregation errors can lead to cell transformation. We hypothesize that the presence of these defects within infected dividing cells identifies a possible mechanism for Chlamydia as a cofactor in cervical cancer formation. Here we demonstrate that infection with Chlamydia trachomatis is able to transform 3T3 cells in soft agar resulting in anchorage independence and increased colony formation. Additionally, we show for the first time Chlamydia infects actively replicating cells in vivo. Infection of mice with Chlamydia results in significantly increased cell proliferation within the cervix, and in evidence of cervical dysplasia. Confocal examination of these infected tissues also revealed elements of chlamydial induced chromosome instability. These results contribute to a growing body of data implicating a role for Chlamydia in cervical cancer development and suggest a possible molecular mechanism for this effect.

  5. Effects of artificial-recharge experiments at Ship Creek alluvial fan on water levels at Spring Acres Subdivision, Anchorage, Alaska

    Science.gov (United States)

    Meyer, William; Patrick, Leslie

    1980-01-01

    The effect of the artificial recharge experiments on water levels at Spring Acres subdivision, Anchorage, Alaska, was evaluated using two digital models constructed to simulate groundwater movement and water-level rises induced by the artificial recharge. The models predicted that the artificial recharge would have caused water levels in the aquifer immediately underlying Spring Acres subdivision to rise 0.2 foot from May 20 to August 7, 1975. The models also predicted a total rise in groundwater levels of 1.1 feet at this location from July 16, 1973 to August 7, 1975, as a result of the artificial-recharge experiments. Water-level data collected from auger holes in March 1975 by a consulting firm for the contractor indicated a depth to water of 6-7 feet below land surface at Spring Acres subdivision at this time. Water levels measured in and near Spring Acres subdivision several years before and after the 1973-75 artificial-recharge experiments showed seasonal rises of 2 to 12.4 feet. A depth to water below land surface of 2.6 feet was measured 600 feet from the subdivision in 1971 and in the subdivision in 1977. Average measured depth to water in the area was 7.0 feet from early 1976 to September 1979. (USGS)

  6. On-site tests to estimate aquifer permeability of drainage area of south caisson anchorage construction of Taizhou Bridge

    Institute of Scientific and Technical Information of China (English)

    Feng Zhaoxiang; Zhao Yanrong

    2011-01-01

    During the construction of the south caisson anchorage of Taizhou Bridge, the drainage area is located in the lower reaches of the Yangtze River and the permeability of stratums there is considerable. In order to maintain progress and guarantee safety during the sinking of the caisson, water should be drained in the initial period. Subsequently, detailed information about the aquifer permeability is required to make sure that the drainage will proceed successfully,which consequently necessitates the on-site estimation of the aquifer permeability in the drainage area. Therefore, the traditional pumping test and slug test are implemented respectively on site. The comparison of computational results of these two tests indicates that they are consistent overall. Notwithstanding, as slug test can be conducted with portable facilities in a short time and the manipulation is easy and few people need to be involved, the advantages of slug test is conspicuous compared with the traditional pumping test. It could be speculated that slug test will gain a prevalent application in the measurement of aquifer permeability in the future.

  7. 口腔正畸治疗中微型种植体支抗的使用价值%Value of micro- implant anchorage in orthodontic treatment

    Institute of Scientific and Technical Information of China (English)

    陈震春

    2011-01-01

    Objective To observe the success rate and effect of micro - implant anchorage in orthodontic treatment. Methods Totally 76 cases of needing orthodontic treatment patients, divided into experimental and control groups, experimental group using the orthodontic mini - implant anchorage method, while the control group using conventional methods of traditional orthodontics, to observe and compare their success rate and treatment. Results The test group and control group, no significant difference between general information, test group successfully planted micro - implant anchorage in 36 cases, the success rate was 97. 4% , growing successful anchorage stability is better, while the control group, 33 cases of successful a success rate of 84. 2% , lower than the experimental group, and the difference was statistically significant (P < 0. 05 ) , the experimental group molar shift less than the control group, the gap between the incisors protruding more than the control group, and the difference was statistically significant (P <0. 05). Conclusions Micro -implant anchorage than the traditional use of conventional methods with better efficacy, a higher success rate, is an ideal orthodontic treatment.%目的 观察微型种植体支抗在口腔正畸治疗中的成功率和效果.方法 选取76例需要正畸的患者,分为试验组和对照组,试验组采用微型种植体支抗的正畸方法,而对照组则采用常规的传统正畸方法,观察和对比其成功率和治疗效果.结果 试验组种植微型种植体支抗成功36例,成功率为97.4%,种植成功的支抗稳定性比较好,而对照组的成功33例,成功率为84.2%,比试验组低,且差异有统计学意义(P<0.05),试验组的磨牙移位比对照组少,上中切牙凸差距均比对照组多,差异有统计学意义(P<0.05).结论 微型种植体支抗的使用比传统的常规方法有着更好的疗效,成功率更高,是一种比较理想的正畸治疗方法.

  8. CFRP预应力筋粘结式锚固系统的抗疲劳性能%Fatigue Behavior of Bond-type Anchorage with CFRP Tendon

    Institute of Scientific and Technical Information of China (English)

    方志; 龚畅; 杨剑; 孙志刚

    2012-01-01

    CFRP预应力筋锚固系统的系统研究成果尤其是疲劳性能研究仍较少,采用疲劳试验机对以高性能活性粉末混凝土RPC作为新型粘结介质的CFRP预应力筋粘结式锚具的疲劳性能进行试验研究,CFRP预应力筋锚固系统疲劳试验采取对组装件交替施加静荷载和疲劳荷载,即用静载试验来检验组装件在经历一定次数重复荷载后的静力性能变化.试验结果表明该类锚具具有良好的抗疲劳性能,随着循环加载次数的增加,组装件之间的相对位置将趋于更加稳定的状态;循环加载过程中CFRP筋抗拉刚度略有降低,疲劳136万次与疲劳前组装件CFRP筋的抗拉刚度比值为93.7%.循环荷载作用下对粘结式锚具组装件有损伤,但当所施加的荷载未超过其极限破断力的40%时,CFRP筋与RPC之间的相对位置将保持比较稳定的状态,此时存在一定损伤的粘结式锚具组装件仍具有较好的承载能力.%The research on the anchorage system for CFRP tendons, especially about the fatigue behavior, is weak. A series of fatigue tests were conducted for the developing a bond-type anchorage system for CFRP tendon characterized with RPC as bond medium by fatigue machine under static load and fatigue load alternatively. Then the static behavior of the anchorage system, which experienced certain cycling loading, was inspected by static load test. The test result shows that (1) the new type of anchorage system has good fatigue behavior, with the increasing of cycling load times, the relative position of the parts of anchorage system at more stable status; (2) the tensile stiffness of CFRP tendons be slightly lower in loading process, after 136 million fatigue tests, it is 93.7% of that before fatigue test; (3) harm of anchorage system will occur under cyclic loading, however the relative slip is smaller between CFRP tendon and RPC under less than 40% of ultimate load, and the higher bearing capacity of harmed

  9. A Component-Based Study of the Effect of Diameter on Bond and Anchorage Characteristics of Blind-Bolted Connections.

    Directory of Open Access Journals (Sweden)

    Muhammad Nasir Amin

    Full Text Available Structural hollow sections are gaining worldwide importance due to their structural and architectural advantages over open steel sections. The only obstacle to their use is their connection with other structural members. To overcome the obstacle of tightening the bolt from one side has given birth to the concept of blind bolts. Blind bolts, being the practical solution to the connection hindrance for the use of hollow and concrete filled hollow sections play a vital role. Flowdrill, the Huck High Strength Blind Bolt and the Lindapter Hollobolt are the well-known commercially available blind bolts. Although the development of blind bolts has largely resolved this issue, the use of structural hollow sections remains limited to shear resistance. Therefore, a new modified version of the blind bolt, known as the "Extended Hollo-Bolt" (EHB due to its enhanced capacity for bonding with concrete, can overcome the issue of low moment resistance capacity associated with blind-bolted connections. The load transfer mechanism of this recently developed blind bolt remains unclear, however. This study uses a parametric approach to characterising the EHB, using diameter as the variable parameter. Stiffness and load-carrying capacity were evaluated at two different bolt sizes. To investigate the load transfer mechanism, a component-based study of the bond and anchorage characteristics was performed by breaking down the EHB into its components. The results of the study provide insight into the load transfer mechanism of the blind bolt in question. The proposed component-based model was validated by a spring model, through which the stiffness of the EHB was compared to that of its components combined. The combined stiffness of the components was found to be roughly equivalent to that of the EHB as a whole, validating the use of this component-based approach.

  10. The G Protein-Coupled Estrogen Receptor-1, GPER-1, Promotes Fibrillogenesis via a Shc-Dependent Pathway Resulting in Anchorage-Independent Growth

    Science.gov (United States)

    Magruder, Hilary T.; Quinn, Jeffrey A.; Schwartzbauer, Jean E.; Reichner, Jonathan; Huang, Allan

    2016-01-01

    The G protein-coupled estrogen receptor-1, GPER-1, coordinates fibronectin (FN) matrix assembly and release of heparan-bound epidermal growth factor (HB-EGF). This mechanism of action results in the recruitment of FN-engaged integrin α5β1 to fibrillar adhesions and the formation of integrin α5β1-Shc adaptor protein complexes. Here, we show that GPER-1 stimulation of murine 4 T1 or human SKBR3 breast cancer cells with 17β-estradiol (E2β) promotes the formation of focal adhesions and actin stress fibers and results in increased cellular adhesion and haptotaxis on FN, but not collagen. These actions are also induced by the xenoestrogen, bisphenol A, and the estrogen receptor (ER) antagonist, ICI 182, 780, but not the inactive stereoisomer, 17α-estradiol (E2α). In addition, we show that GPER-1 stimulation of breast cancer cells allows for FN-dependent, anchorage-independent growth and FN fibril formation in “hanging drop” assays, indicating that these GPER-1-mediated actions occur independently of adhesion to solid substrata. Stable expression of Shc mutant Y317F lacking its primary tyrosyl phosphorylation site disrupts E2β-induced focal adhesion and actin stress fiber formation and abolishes E2β-enhanced haptotaxis on FN and anchorage-dependent growth. Collectively, these data demonstrate that E2β action via GPER-1 enhances cellular adhesivity and FN matrix assembly and allows for anchorage-independent growth, cellular events that may allow for cellular survival, and tumor progression. PMID:25096985

  11. Mouse Balb/c3T3 cell mutant with low epidermal growth factor receptor activity: induction of stable anchorage-independent growth by transforming growth factor β

    International Nuclear Information System (INIS)

    A mutant clone (MO-5) was originally isolated as a clone resistant to Na+/K+ ionophoric antibiotic monensin from mouse Balb/c3T3 cells. MO-5 was found to show low receptor-endocytosis activity for epidermal growth factor (EGF):binding activity for EGF in MO-5 was less than one tenth of that in Balb/c3T3. Anchorage-independent growth of MO-5 was compared to that of Balb/c3T3 when assayed by colony formation capacity in soft agar. Coadministration of EGF and TGF-β efficiently enhanced anchorage-independent growth of normal rat kidney (NRK) cells, but neither factor alone was competent to promote the anchorage-independent growth. The frequency of colonies appearing in soft agar of MO-5 or Balb/c3T3 was significantly enhanced by TGF-β while EGF did not further enhance that of MO-5 or Balb/c3T3. Colonies of Balb/c3T3 formed in soft agar in the presence of TGF-β showed low colony formation capacity in soft agar in the absence of TGF-β. Colonies of MO-5 formed by TGF-β in soft agar, however, showed high colony formation capacity in soft agar in the absence of TGF-β. Pretreatment of MO-5 with TGF-β induced secretion of TGF-β-like activity from the cells, while the treatment of Balb/c3T3 did not induce the secretion of a significant amount of TGF-β-like activity. The loss of EGF-receptor activity in the stable expression and maintenance of the transformed phenotype in MO-5 is discussed

  12. Thermal Pollution Mathematical Model. Volume 6: Verification of Three-Dimensional Free-Surface Model at Anclote Anchorage. [environment impact of thermal discharges from power plants

    Science.gov (United States)

    Lee, S. S.; Sengupta, S.; Tuann, S. Y.; Lee, C. R.

    1980-01-01

    The free-surface model presented is for tidal estuaries and coastal regions where ambient tidal forces play an important role in the dispersal of heated water. The model is time dependent, three dimensional, and can handle irregular bottom topography. The vertical stretching coordinate is adopted for better treatment of kinematic condition at the water surface. The results include surface elevation, velocity, and temperature. The model was verified at the Anclote Anchorage site of Florida Power Company. Two data bases at four tidal stages for winter and summer conditions were used to verify the model. Differences between measured and predicted temperatures are on an average of less than 1 C.

  13. Clinical application of mini-implant anchorage in orthodontics%钛金属微种植体钉作为支抗的临床应用

    Institute of Scientific and Technical Information of China (English)

    陈亚刚; 王兴; 吴文文

    2011-01-01

    BACKGROUND: Mini-implant anchorage is widely used in orthodontic fie Id. because it is small, easy to implant, use and remove,reliable in therapeutic effect and low cost.OBJECTIVE: To study the clinical application and effect of mini-implant anchorage in orthodontics.METHODS: The cep halo metric analysis was performed in 38 patients to compare overbite, coverage, molar relationship and thedegree of anterior adductor before and after treatment.RESULTSAHD CONCLUSION: The total number of mini-implants was 106, and allthe mini-implant anchorages weresuccessfully implanted except 3 cases required secondary operation with 5 loosen implants and one patient with loss of 2implants required re-implantation. Mini-implant anchorages make the treatment process s imple and acceptable in clinicalapplication.%背景:微种植体支抗因其体积小,植入、使用和去除简单,疗效可靠且成本低廉在正畸领域得到了广泛的应用.目的:观察分析钛金属微种植体支抗在口腔正畸中的应用效果.方法:对38例微种植体患者的投影测量分析,比较治疗前后的覆牙合、覆盖、磨牙关系和前牙内收程度等.结果与结论:微螺钉种植体植入总数106枚,除3例患者因5枚种植体松动再次手术植入,1例患者因2枚种植体脱落拒绝再次植入而改用传统支抗外,其他病例均获得了满意的治疗效果,建立了正常的前牙覆牙合、覆盖关系,患者面型得到了明显的改善.微种植体矫治过程相对简单,患者易于接受.

  14. Anchorage-independent growth of Ewing sarcoma cells under serum-free conditions is not associated with stem-cell like phenotype and function.

    Science.gov (United States)

    Leuchte, Katharina; Altvater, Bianca; Hoffschlag, Simeon; Potratz, Jenny; Meltzer, Jutta; Clemens, Dagmar; Luecke, Andrea; Hardes, Jendrik; Dirksen, Uta; Juergens, Heribert; Kailayangiri, Sareetha; Rossig, Claudia

    2014-08-01

    Novel treatment strategies for Ewing sarcoma aim to eliminate residual tumor cells that have maintained the capacity to reinitiate tumor growth after intensive conventional therapy. Preclinical models that more closely mimic in vivo tumor growth than standard monolayer cultures are needed. Sphere formation under anchorage-independent, serum-free conditions has been proposed to enrich for cells with tumor-initiating, stem cell-like properties in various solid cancers. In the present study, we assessed the phenotype and functional stem cell characteristics of Ewing sarcoma spheres. Spheres were generated under serum-free culture conditions from four Ewing sarcoma cell lines and four relapse tumor biopsies. Standard monolayer cultures were established as controls. Median levels of surface expression of the Ewing sarcoma marker CD99 as well as the supposed stem cell marker CD133 and the neural crest marker CD57 were comparable between spheres and monolayers. Ewing sarcoma spheres from individual tumors failed to continuously self-renew by secondary sphere formation. They contained variable proportions of side populations (SPs). Sphere culture did not enhance the in vivo tumorigenicity of Ewing sarcoma cells in a murine xenograft model. We conclude that sphere formation under serum-free conditions is not a reliable tool to enrich for cells with stem cell characteristics in Ewing sarcoma. By mimicking the anchorage-independent, multicellular growth of Ewing sarcoma micrometastases, in vitro sphere growth may still add value as a preclinical tool to evaluate the efficacy of novel therapeutics. PMID:24927333

  15. Anchorages - USACE IENC

    Data.gov (United States)

    Department of Homeland Security — These inland electronic Navigational charts (IENCs) were developed from available data used in maintenance of Navigation channels. Users of these IENCs should be...

  16. Based on the Theory of Queuing for the VLCC Anchorage Admeasurements Assessment of Lanshan Port%基于排队论的岚山港大型油轮锚地容量评估

    Institute of Scientific and Technical Information of China (English)

    张锡海

    2012-01-01

    为了评估拟建码头的配套锚地容量是否满足要求,应用排队论对锚地容量进行了数学建模,并利用该模型对岚山港大型油轮锚地进行了计算分析,得出该锚地容量满足到港船舶安全锚泊的需要,证明了用排队论来评估锚地容量是可行的。%In order to evaluate the anchorage admeasurements to meet the requirements of the proposed wharf,establishing the mathematical model for anchorage admeasurements according to the queuing theory, and calculating the VLCC anchorage admeasurements of Lanshan Port,the results show that the anchorage admeas- urements can meet the needs of vessels anchor safetyo It is prove using the queuing theory to assess the anchor- age admeasurements is feasible.

  17. 微型种植体支抗用于口腔正畸治疗临床分析%Micro implant anchorage in orthodontic treatment clinical analysis

    Institute of Scientific and Technical Information of China (English)

    张栋

    2014-01-01

    Objective to analyze the micro-implant anchorage in orthodontic treatment application results. Methods 60 cases of patients treated with orthodontic mini-implant anchorage implants, after correction for patients before and after correction of complications and the shifting of the implant were observed and compared. Results all of the micro-implant patients remain stable after 1 month of treatment, the front teeth have reached the normal coverage and other. in addition, the patients had no infectious complications. compared with the prior correction, the correction after three weeks and a month has shown a shift situation, but after three weeks compared with the correction, the correction after a month shifting signiifcantly, P<0.05. Conclusion micro implant anchorage in orthodontic applications, good stability, fewer complications.%目的:分析微型种植体支抗在口腔正畸治疗中应用效果。方法60例口腔正畸治疗患者植入微型种植体支抗,对患者矫正后的并发症情况和矫正前后种植体的移位情况进行观察比较。结果所有患者的微型种植体都保持稳定,治疗1个月后,前牙都达到了正常的覆盖等。此外,患者均无感染并发症。与矫正前相比,矫正后3周以及1个月都出现了移位情况,但是与矫正后3周比较,矫正后1个月移位情况明显,P<0.05。结论采用微型种植体支抗在口腔正畸中应用,稳定性好,并发症少。

  18. Stability and safety of mini-implant anchorage in orthodontic treatment%口腔正畸治疗中微型种植体支抗的稳定和安全性

    Institute of Scientific and Technical Information of China (English)

    刘洪; 牟雁东; 于晓光; 彭凤英; 李庆华; 邓富华

    2016-01-01

    BACKGROUND: Traditional orthodontic anchorage has the disadvantages of discomfort, difficult to control, affecting the appearance, and relying on patient’s close cooperation. Because of short-time clinical research and application, mini-implant anchorage has a great controversy in the orthodontic treatment. OBJECTIVE: To explore the application value of mini-implant anchorage in the orthodontic treatment. METHODS:Eighty cases undergoing the orthodontic treatment at the Center of Ophthalmology and Otolaryngology, Yaan People’s Hospital in China from January 2012 to June 2015 were enrol ed in this study. These patients were equal y randomized into test group and control group, which were subjected to mini-implant anchorage or headgear anchorage, respectively. The treatment was continued for 2 years in the two groups. RESULTS AND CONCLUSION: After the treatment, the successful rate in the test group was significantly higher than that in the control group (P 0.05), but the rate of adverse reactions was significantly lower in the test group than the control group (P 0.05)。但试验组患者的不良反应率明显低于对照组(P <0.05)。说明微型种植体支抗能够明显提高口腔正畸治疗患者的治疗效果,提高治疗成功率,降低术后感染发生率,具有较好的安全性和稳定性,具有较好的临床应用价值。

  19. Nonsurgical treatment of an adult with an open bite and large lower anterior facial height with edgewise appliances and temporary anchorage devices.

    Science.gov (United States)

    Fukui, Tadao; Kano, Hiroyuki; Saito, Isao

    2016-06-01

    A woman was referred to the orthodontic clinic for treatment. She was diagnosed with a skeletal Class II malocclusion, a steep mandibular plane, and an anterior open bite. Conventional orthodontic treatment was considered to correct the maxillary protrusion and anterior open bite, but the patient also requested improvement of her facial esthetics. We therefore decided that nonsurgical treatment consisting of 4 premolar extractions combined with temporary anchorage devices was indicated. Satisfactory improvement of the overjet and overbite, and proper functional occlusion were obtained, resulting in a Class I molar relationship. Active treatment was completed in 2 years 10 months, and the result remained stable at 2 years 6 months after debonding. PMID:27242000

  20. Use of reconstructed CT images for evaluation of the position of screw-type temporary anchorage devices implanted in the maxillary molar region

    International Nuclear Information System (INIS)

    Temporary anchorage devices (TAD) have recently been employed for orthodontic treatment. I attempted to find the safest position for placing the screw-type TAD in the maxillary molar region. Using reconstructed CT images, I investigated the buccolingual and mesiodistal lengths of the interalveolar septums between the maxillary first premolar, second premolar, first molar, and the second molar. For the first and second molars, I measured the distance from the alveolar crest to the maxillary sinus. The results indicated that the safest position for placing a screw-type TAD was the interalveolar septum between the maxillary first molar and the second premolar at about a depth of 4-6 mm from the alveolar crest on the buccal side, and at about a depth of 2-6 mm from the alveolar crest on the palatal side. (author)

  1. Clinical study of stability of micro implant used as orthodontic anchorage%正畸微型种植体的临床应用研究

    Institute of Scientific and Technical Information of China (English)

    招惠珍; 殷慧; 黄纪美

    2012-01-01

    目的 微型种植体承受正畸力后的稳定性研究.方法 回顾2008年3月至2011年3月在佛山市禅城区中心医院口腔科确诊的安氏Ⅱ类错颌畸形患者26例,在上颌第二前磨牙与第一磨前牙之间的牙槽骨上植入微型种植体,用以支抗内收的上前牙.并于植入种植体后2周、6个月时摄X线头颅定位侧位片,比较加力前后变化,测量微型种植体的移位情况.结果 6个月后水平位移约为0.5mm,垂直位移平均约为0.4mm,与植入时相比具有统计学意义(P<0.05),其中微型种植体伸长者7例,占26.9%.结论 微型种植体是一种相对稳定的支抗,在承受正畸力后,会出现位置移动以及自体伸长,所以在微型种植体植入时要注意避开血管、神经丰富的区域,植入后要定期复诊.%Objective To study the stability of micro implant anchorage after orthodontic force. Methods Totally 26 patients with micro implants as the maxillary anchorage from March 2008 to March 2011 to in our hospital were included in this study. Micro implants were inserted on the maxillary alveolar between the second premolar and the first molar as a direct anchorage for anterior teeth retraction. And at 2 weeks after implant placement, 6 months, X ray skull lateral positioning, comparing changes before and after the afterburner, measuring micro - implant shifting. Results After 6 months the horizontal displacement of approximately 0. 5 mm, the average vertical displacement of approximately 0. 4mm, with statistically significant when compared to implants (P < 0. 05 ) , which mini - implant elongation in 7 cases, 26.9%. Conclusions Micro implants is a relatively stable anchorage to withstand orthodontic force, the position will be mobile and self - body stretch, so the mini - implant should pay attention to avoid the blood vessels, nerve - rich are-a, regular follow - up after implantation.

  2. Exposure to Bisphenol A Correlates with Early-Onset Prostate Cancer and Promotes Centrosome Amplification and Anchorage-Independent Growth In Vitro

    Science.gov (United States)

    Tarapore, Pheruza; Burke, Barbara; Bracken, Bruce; Ho, Shuk-Mei

    2014-01-01

    Human exposure to bisphenol A (BPA) is ubiquitous. Animal studies found that BPA contributes to development of prostate cancer, but human data are scarce. Our study examined the association between urinary BPA levels and Prostate cancer and assessed the effects of BPA on induction of centrosome abnormalities as an underlying mechanism promoting prostate carcinogenesis. The study, involving 60 urology patients, found higher levels of urinary BPA (creatinine-adjusted) in Prostate cancer patients (5.74 µg/g [95% CI; 2.63, 12.51]) than in non-Prostate cancer patients (1.43 µg/g [95% CI; 0.70, 2.88]) (p = 0.012). The difference was even more significant in patients <65 years old. A trend toward a negative association between urinary BPA and serum PSA was observed in Prostate cancer patients but not in non-Prostate cancer patients. In vitro studies examined centrosomal abnormalities, microtubule nucleation, and anchorage-independent growth in four Prostate cancer cell lines (LNCaP, C4-2, 22Rv1, PC-3) and two immortalized normal prostate epithelial cell lines (NPrEC and RWPE-1). Exposure to low doses (0.01–100 nM) of BPA increased the percentage of cells with centrosome amplification two- to eight-fold. Dose responses either peaked or reached the plateaus with 0.1 nM BPA exposure. This low dose also promoted microtubule nucleation and regrowth at centrosomes in RWPE-1 and enhanced anchorage-independent growth in C4-2. These findings suggest that urinary BPA level is an independent prognostic marker in Prostate cancer and that BPA exposure may lower serum PSA levels in Prostate cancer patients. Moreover, disruption of the centrosome duplication cycle by low-dose BPA may contribute to neoplastic transformation of the prostate. PMID:24594937

  3. Exposure to bisphenol A correlates with early-onset prostate cancer and promotes centrosome amplification and anchorage-independent growth in vitro.

    Directory of Open Access Journals (Sweden)

    Pheruza Tarapore

    Full Text Available Human exposure to bisphenol A (BPA is ubiquitous. Animal studies found that BPA contributes to development of prostate cancer, but human data are scarce. Our study examined the association between urinary BPA levels and Prostate cancer and assessed the effects of BPA on induction of centrosome abnormalities as an underlying mechanism promoting prostate carcinogenesis. The study, involving 60 urology patients, found higher levels of urinary BPA (creatinine-adjusted in Prostate cancer patients (5.74 µg/g [95% CI; 2.63, 12.51] than in non-Prostate cancer patients (1.43 µg/g [95% CI; 0.70, 2.88] (p = 0.012. The difference was even more significant in patients <65 years old. A trend toward a negative association between urinary BPA and serum PSA was observed in Prostate cancer patients but not in non-Prostate cancer patients. In vitro studies examined centrosomal abnormalities, microtubule nucleation, and anchorage-independent growth in four Prostate cancer cell lines (LNCaP, C4-2, 22Rv1, PC-3 and two immortalized normal prostate epithelial cell lines (NPrEC and RWPE-1. Exposure to low doses (0.01-100 nM of BPA increased the percentage of cells with centrosome amplification two- to eight-fold. Dose responses either peaked or reached the plateaus with 0.1 nM BPA exposure. This low dose also promoted microtubule nucleation and regrowth at centrosomes in RWPE-1 and enhanced anchorage-independent growth in C4-2. These findings suggest that urinary BPA level is an independent prognostic marker in Prostate cancer and that BPA exposure may lower serum PSA levels in Prostate cancer patients. Moreover, disruption of the centrosome duplication cycle by low-dose BPA may contribute to neoplastic transformation of the prostate.

  4. 微螺钉种植体支抗压低磨牙矫治前牙开(牙合)%Treatment of anterior open bite using miniscrew anchorage

    Institute of Scientific and Technical Information of China (English)

    寻春雷; 曾祥龙

    2010-01-01

    近些年来各种骨性支抗系统被开发并应用于临床,来完成牙齿各种类型的运动.微型种植体用于垂直支抗控制方面比传统方法有着更多的优势.本文病例通过应用自攻型微钛钉种植体支抗压低上下颌后部牙齿槽,治疗严重的骨性前牙开(牙合)畸形,证明自攻型微钛钉种植体提供垂直支抗控制的能力.本文也提示通过简单有效的骨性支抗手段,可以提供一种治疗较复杂骨性开(牙合)畸形的全新方法.%Skeletal anterior open bite is one type of the complicated malocclusions. It is critical to decrease the heights of posterior dentoalveolar reigons for successful treatment of anterior open bite.To obzain a stationary anchorage source, special designed implant and minisrew, miniplate have been developed recently in orthodontic clinic. Compared to traditional methods, mini-implant have more advantages in vertical control This report confirmed the effectiveness of miniscrew anchorage in skeletal anterior open bite treatment and showed the results of dental, skeletal and soft tissue profile treatment changes with the intrusion of posterior dentoalveolar segment.

  5. 微不锈钢种植体支抗的稳定性研究%Study on the stability of stainless miniscrew used as orthodontic anchorage

    Institute of Scientific and Technical Information of China (English)

    李永峰; 肖选队; 何站峰; 王朝彦; 孙晓爱

    2011-01-01

    Objective To study the stability of stainless steel implant used as anchorage under different force time. Methods Twenty malocclusional patients(10males,10females average age 16-18 years old)with a total forty miniscrews were examined.Miniscrews were insered on the maxillary tooth-bearing area between the second bicuspid and the first molar as a direct anchorage for anterior teeth extraction.AII the patients were divided into 2 groups.Force was activated immediately by nickel-titanium coil springs in group 1 after the insertion of the mini-screws.After 4 weeks the force was applied in group 2.the distance about the movement of the forced miniscrew were mearsured by the cephalometric radiographs at the beginning and half year later. Results In group 1,the miniscrews were tipped vertically 1.53mm and the sagittal distance of movement was 1.31mm on average.ln group 2,the distance was 0.83mm sagittally and 1.03mm vertically. Conclusion The stainless steel miniscrew could provide enough anchorage control for anterior teeth extraction. It is more stable for force exertion on after 4 weeks.%目的:分析不同施力时间对微不锈钢种植支抗稳定性的影响.方法:选择20例错牙合畸形患者(男10例,女10例),年龄16~18岁,分别将种植钉被植入每位患者上颌两侧第一前磨牙和第一磨牙区作为种植钉支抗内收前牙,共植入40颗不锈钢种植钉.男女患者按加载时间不同被随机平分为两组,实验组1:种植钉植入后便采用镍钛拉簧即刻加力,实验组2:4周后在进行加力,分别通过头颅侧位片测量种植钉加载前后半年的位移变化.然后对两个实验组进行统计学分析.结果:实验组1:种植钉在矢状向上平均移动了1.31mm,垂直向上平均移动了1.53mm.实验组2:种植钉在矢状向和垂直向的平均位移是0.83mm和1.03mm.结论:不锈钢种植钉能够为内收前牙提供稳定和可靠的支抗,植入4周后再施力更有助于种植钉的稳定.

  6. 锚固条件下矿用锚索中纵向导波传播特性的实验研究%Tests for propagation characteristics of longitudinal guided waves in an anchored mining anchorage cable

    Institute of Scientific and Technical Information of China (English)

    吴斌; 方舟; 刘增华; 何存富

    2014-01-01

    实验研究了矿用锚索的锚固段长度对纵向超声导波 L(0,1)模态的衰减与群速度的影响。首先,通过简化为细直杆的钢丝中纵向超声导波的频散曲线分析了无锚固矿用锚索中该模态的传播特性。然后采用厚度振动型压电陶瓷片在水泥锚固条件下的矿用锚索中进行穿透法的实验,得出频段20-500 kHz 内 L(0,1)模态的幅值,确定了该压电陶瓷片对水泥锚固条件下的锚固矿用锚索的最佳导波检测频率为280 kHz。在此基础上,研究了280 kHz 附近频率点下L(0,1)模态的幅值与群速度随水泥锚固段长度增加的变化规律。最后,对矿用树脂锚固条件下的矿用锚索进行了穿透法的实验,该实验结果与水泥锚固条件下的锚固矿用锚索的实验结果相符合。这些实验为利用纵向超声导波测量锚固条件下矿用锚索的长度奠定了基础。%The effect of anchored length of a mining anchorage cable on amplitude attenuation and group velocity of ultrasonic longitudinal guided wave mode L(0,1)was investigated experimentally.Firstly,the propagation characteristics of ultrasonic longitudinal guided wave in a mining anchorage cable unanchored were analyzed with the dispersion curves of a steel wire simplified as a rod.Then,a piezoelectric element of thickness vibration type was used to perform a through-transmission test in a mining anchorage cable anchored with cement,and the amplitudes of L(0,1)mode were acquired in the frequency range of 20-500kHz.The piezoelectric element’s most suitable monitoring frequency for guided wave in the mining anchorage cable anchored with cement was 280kHz.Based on this result,the amplitude attenuation and group velocity variation characteristics of L(0,1)mode at several frequencies near 280kHz were studied in the mining anchorage cable with increase in anchored length.Finally,the through-transmission tests were performed in a mining anchorage

  7. 探讨微型种植体支抗在口腔正畸中的临床应用%The Clinical Application of Micro-Implant Anchorage in Treating Orthodontics

    Institute of Scientific and Technical Information of China (English)

    方颖峰; 沈玥

    2014-01-01

    Object: To explore the clinical application of micro-implant anchorage in treating orthodontics. Methods: From January 2013 to December 2013, 50 cases orthodontics patients treated by micro-implant anchorage were observed and the effect of micro-implant anchorage was discussed. Results: Mini-implants were transplanted well with good stability, and there were no of loose and fall off occurred. Besides, the tooth arrangements were also corrected and the degrees of beautiful shape were significantly improved. Conclusions: Micro-implant anchorage in treating orthodontics showed better clinical application; simultaneously improved the tooth’s apparent, worth clinical promotion.%目的:探讨微型种植体支抗在口腔正畸中的应用和临床疗效。方法选取2013年1月至2013年12月期间在我院50例以微型种植体支抗进行口腔正畸治疗的患者作为调查对象。并探讨微型种植体支抗在口腔正畸中的作用。结果此次调查中,微型种植体均能良好植入,且植入后,微型种植体稳定性好、无松动、脱落等情况的发生。此外,患者牙齿排列也得到较好的矫正,外形美观程度有明显提升。结论微型种植体支抗在口腔正畸中可获得较好的临床应用,同时还可改善患者牙齿外观,可在临床上广泛推广。

  8. Mesialização de molares com ancoragem em mini-implantes Mesial movement of molars with mini-implants anchorage

    Directory of Open Access Journals (Sweden)

    Marcos Janson

    2008-10-01

    Full Text Available INTRODUÇÃO: é muito comum, na rotina do consultório odontológico, especialmente em Ortodontia, o paciente, após avaliar o plano de tratamento proposto, questionar sobre a possibilidade de fechamento de espaços presentes, ocasionados pela perda de dentes permanentes. O ortodontista, frente a essa questão, tem que avaliar diversos fatores, tais como a má oclusão presente, a integridade do osso e das raízes, o tempo de tratamento e a geometria do posicionamento dentário, que é o que permite avaliar se, com o fechamento dos espaços e, conseqüentemente, a perda de ancoragem dos segmentos anteriores, a finalização estará de acordo com os ideais que regem a especialidade. Com o advento dos mini-implantes, as possibilidades desta abordagem terapêutica aumentaram, pois o efeito adverso da perda de ancoragem pode ser eliminado e, com isso, o paciente pode ser beneficiado. No entanto, os outros fatores envolvidos, assim como a mecânica do movimento, requerem especial atenção. OBJETIVOS: no presente artigo serão abordados os fatores envolvidos neste tipo de tratamento, o raciocínio na tomada de decisões e os detalhes importantes que devem ser observados durante a condução da mecânica, ilustrados com casos clínicos.INTRODUCTION: It's routine, especially at the orthodontic office, the patient, after the assessment of the proposed treatment plan, answer about the possibility of closing their edentulous spaces caused by missed permanent teeth. In these situations, several factors must be evaluated, like the present malocclusion, the bone and roots integrity, the treatment time and the geometry of teeth positioning, that is what permits to assess if the loss of anchorage from the anterior segments, during the space closure, would permit the occlusion to end within the orthodontic ideals. With the mini-implants, the possibilities of this therapeutic approach have been improved, since the adverse effects are eliminated with the

  9. 微种植体支抗在安氏Ⅱ类1分类错牙合中的应用%The Application of Micro-implants Anchorage in Angle Class Ⅱ Division 1 Malocclusion

    Institute of Scientific and Technical Information of China (English)

    王铭蔚

    2012-01-01

    Angle class Ⅱ division 1 malocclusion prevalence is high. The premise of such disease to be successfully treated is the perfect anchorage control. Mini-implants anchorage provides stable anchorage effects for the orthodontic treatment, which is recognized and accepted by the majority of physicians. In practical application process, how to optimize the use of micro-implants to treatment of Angle class Ⅱ division 1 malocclusion is one of the difficulties in orthodontic.%安氏Ⅱ类1分类错牙合畸形患病率较高,正确的支抗设计和良好的支抗控制是这类错牙合获得成功矫治的前提.近年来,微种植体支抗由于为正畸治疗中提供稳定支抗效果而逐渐被广大医师认识和接受.在实际应用过程中,如何优化使用微种植体治疗安氏Ⅱ类1分类错牙合是当今正畸治疗的难点之一.

  10. 微种植体支抗压低前牙的临床与基础研究%The clinical and basic research of mini -implant anchorage for the anterior teeth intrusion

    Institute of Scientific and Technical Information of China (English)

    王亚楠; 杨四维

    2013-01-01

    The traditional methods are often not effective in intruding the anterior teeth, opening the bite and improv-ing the gummy smile during the orthodontic treatment. Mini-implant anchorage as an absolute anchorage can be im-planted into any part of the jaw. It can apply the absolute intrusion and also can produce a good clinical treatment effect. The aim of this article was to review the clinical and basic research of mini-implant anchorage for the anteri-or teeth intrusion.%  正畸临床矫治中在压低前牙,打开咬合,改善露龈笑时,传统方法对前牙施行绝对压低的效果往往不理想。微种植体支抗作为一种绝对支抗可植入颌骨任何部位,对前牙实施绝对的压低,产生良好的临床矫治效果。本文对微种植体支抗压低前牙的临床与基础研究作一综述。

  11. The effect of canine disimpaction performed with temporary anchorage devices (TADs) before comprehensive orthodontic treatment to avoid root resorption of adjacent teeth

    Science.gov (United States)

    Heravi, Farzin; Shafaee, Hooman; Forouzanfar, Ali; Zarch, Seyed Hossein Hoseini; Merati, Mohsen

    2016-01-01

    ABSTRACT Objective: The aim of this study was to evaluate the movement of impacted canines away from the roots of neighboring teeth before full-mouth bracket placement, performed by means of TADs to decrease undesired side effects on adjacent teeth. Methods: The study sample consisted of 34 palatally impacted canines, being 19 in the experimental group and 15 in the control group. In the experimental group, before placement of brackets, the impacted canine was erupted by means of miniscrews. In the control group, after initiation of comprehensive orthodontics, canine disimpaction was performed by means of a cantilever spring soldered to a palatal bar. At the end of treatment, volume of lateral incisors and canine root resorption were measured and compared by means of a CBCT-derived tridimensional model. Visual Analogue Scale (VAS) score, bleeding on probing (BOP) and gingival index (GI) were recorded. Clinical success rate was also calculated. Results: The volume of root resorption of lateral teeth in the control group was significantly greater than in the experimental group (p < 0.001). At the end of treatment, VAS score, GI and BOP were not significantly different between the two groups. Conclusion: Based on our results, it seems that disimpaction of canines and moving them to the arch can be done successfully carried out with minimal side effects by means of skeletal anchorage. PMID:27275617

  12. MicroRNA let-7b targets important cell cycle molecules in malignant melanoma cells and interferes with anchorage-independent growth

    Institute of Scientific and Technical Information of China (English)

    Julia Schultz; Peter Lorenz; Gerd Gross; Saleh Ibrahim; Manfred Kunz

    2008-01-01

    A microRNA expression screen was performed analyzing 157 different microRNAs in laser-microdissected tissues from benign melanocytic nevi (n=10) and primary malignant melanomas (n=10),using quantitative real-time PCR.Differential expression was found for 72 microRNAs.Members of the let-7 family of microRNAs were significantly downregulated in primary melanomas as compared with benign nevi,suggestive for a possible role of these molecules as tumor suppressors in malignant melanoma.Interestingly,similar findings had been described for lung and colon cancer.Overexpression of let-7b in melanoma cells in vitro downregulated the expression of cyclins D1,D3,and A,and cyclin-dependent kinase (Cdk) 4,all of which had been described to play a role in melanoma development.The effect oflet-7b on protein expression was due to targeting of 3'-untranslated regions (3'UTRs) of individual mRNAs,as exemplified by reporter gene analyses for cyclin DI.In line with its downmodulating effects on cell cycle regulators,let-7b inhibited cell cycle progression and anchorage-independent growth of melanoma cells.Taken together,these findings not only point to new regulatory mechanisms of early melanoma development,but also may open avenues for future targeted therapies of this tumor.

  13. Induction of anchorage-independent growth in primary human cells exposed to protons or HZE ions separately or in dual exposures.

    Science.gov (United States)

    Sutherland, B M; Cuomo, N C; Bennett, P V

    2005-10-01

    Travelers on space missions will be exposed to a complex radiation environment that includes protons and heavy charged particles. Since protons are present at much higher levels than are heavy ions, the most likely scenario for cellular radiation exposure will be proton exposure followed by a hit by a heavy ion. Although the effects of individual ion species on human cells are being investigated extensively, little is known about the effects of exposure to both radiation types. One useful measure of mammalian cell damage is induction of the ability to grow in a semi-solid agar medium highly inhibitory to the growth of normal human cells, termed neoplastic transformation. Using primary human cells, we evaluated induction of soft-agar growth and survival of cells exposed to protons only or to heavy charged particles (600 MeV/nucleon silicon) only as well as of cells exposed to protons followed after a 4-day interval by silicon ions. Both ions alone efficiently transformed the human cells to anchorage-independent growth. Initial experiments indicate that the dose responses for neoplastic transformation of cells exposed to protons and then after 4 days to silicon ions appear similar to that of cells exposed to silicon ions alone. PMID:16187755

  14. Evaluation of stress patterns on maxillary posterior segment when intruded with mini implant anchorage: A three-dimensional finite element study

    Directory of Open Access Journals (Sweden)

    Nikhita Pekhale

    2016-01-01

    Full Text Available Introduction: The aim of this study is to evaluate stress and displacement effects of maxillary posterior intrusion mechanics with mini-implant anchorage by using finite element method. Materials and Methods: A computer stimulation of three-dimensional model maxilla with all teeth, PDL, bone, mini-implants, brackets, arch wire, force element, and transpalatal arch was constructed on the basis of average anatomic morphology. Finite element analysis was done to evaluate the amount of stress and its distribution during orthodontic intrusive force. Results: Increased Von Mises stress values were observed in mesio-cervical region of first molar. The middle third of second premolar and second molar and regions adjacent to force application sites also showed relatively high stress values. Minimum stress values were observed in apical region of first premolar as it is away from force application. Conclusion: Using three mini-implant and transpalatal arches, this study demonstrates that significant amount of true intrusion of maxillary molars could be obtained with lesser concentration of stresses in the apical area recorded.

  15. Cellular Dichotomy Between Anchorage-Independent Growth Responses to bFGF and TA Reflects Molecular Switch in Commitment to Carcinogenesis

    Energy Technology Data Exchange (ETDEWEB)

    Waters, Katrina M.; Tan, Ruimin; Opresko, Lee K.; Quesenberry, Ryan D.; Bandyopadhyay, Somnath; Chrisler, William B.; Weber, Thomas J.

    2009-11-01

    We have investigated gene expression patterns underlying reversible and irreversible anchorage-independent growth (AIG) phenotypes to identify more sensitive markers of cell transformation for studies directed at interrogating carcinogenesis responses. In JB6 mouse epidermal cells, basic fibroblast growth factor (bFGF) induces an unusually efficient and reversible AIG response, relative to 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced AIG which is irreversible. The reversible and irreversible AIG phenotypes are characterized by largely non-overlapping global gene expression profiles. However, a subset of differentially expressed genes were identified as common to reversible and irreversible AIG phenotypes, including genes regulated in a reciprocal fashion. Hepatic leukemia factor (HLF) and D-site albumin promoter-binding protein (DBP) were increased in both bFGF and TPA soft agar colonies and selected for functional validation. Ectopic expression of human HLF and DBP in JB6 cells resulted in a marked increase in TPA- and bFGF-regulated AIG responses. HLF and DBP expression were increased in soft agar colonies arising from JB6 cells exposed to gamma radiation and in a human basal cell carcinoma tumor tissue, relative to paired non-tumor tissue. Subsequent biological network analysis suggests that many of the differentially expressed genes that are common to bFGF- and TPA-dependent AIG are regulated by c-Myc, SP-1 and HNF-4 transcription factors. Collectively, we have identified a potential molecular switch that mediates the transition from reversible to irreversible AIG.

  16. 分析微螺钉种植体支抗在口腔正畸中的临床效果%Clinical Analysis of the Effect of Micro Screw Implant Anchorage in Orthodontic Treatment

    Institute of Scientific and Technical Information of China (English)

    赵嘉颖

    2015-01-01

    Objective To study the analysis of orthodontic Mini screw implant use result of anchorage.Methods According to the 82 cases of orthodontic patients in our hospital received to carry on the research analysis, these patients were grouped into control group and observation group, in al 41 cases patients, patients in the control group received orthodontic anchorage in treatment, the observation group use micro screw implant anchorage treatment, carries on the comparative analysis of orthodontic clinical effect of two groups of patients.Results The clinical observation of the patients in the treatment group the effective rate was 97.56%, the effective rate of the control group was 87.8%; the patients in the observation group were molars shift to lower than the control group, upper incisor inclination than the control group. Conclusion The use of micro screw implant anchorage has very good effect in orthodontic treatment, compared to the conventional anchorage effect is more prominent, and has great application value in clinical, it is worth to promote the use.%目的:研究分析口腔正畸使用微螺钉种植体支抗的效果。方法根据我院接收的82例口腔正畸患者来进行研究分析,将这些患者分组为对照组和观察组,均有41例患者,对照组患者接受正畸支抗治疗,观察组使用微螺钉种植支抗治疗,对两组患者的临床正畸效果进行比较分析。结果观察组患者的临床治疗有效率是97.56%,对照组的有效率是87.8%;观察组患者的磨牙移位要比对照组低,上中切牙倾角差比对照组高。结论在口腔正畸治疗时使用微螺钉种植支抗具有非常好的效果,相比常规的支抗效果更加突出,在临床具有较大的应用价值,值得推广使用。

  17. The Factors Affecting the Primary Stability of Mini-implant Anchorage%影响微种植体支抗初期稳定性的因素

    Institute of Scientific and Technical Information of China (English)

    王硕; 贺娇娇; 刘畅

    2015-01-01

    The use of mini-implants anchorage for the orthodontic and orthopedic treatment is an effec-tive and ideal method.It enlarges the treatment scope in clinic for its stability and efficiency .According to the implantation site and the quality of local bone tissue,it is essential to select the appropriate size of the mini-implants,implantation angle and implantation method for establishing adequate initial stability .Considerable researches have been done to investigate the initial stability of orthodontic mini-implants.Here is to make a review of the influencing factors of the primary stability of orthodontic mini-implants.%利用微种植体作为支抗装置进行正畸和矫形治疗是一种高效、理想的方法。微种植体支抗的应用使临床可矫治的范围大大增加。根据植入部位和局部骨组织的质量,适当选择微种植体的尺寸与植入角度和植入方式对建立足够的初期稳定性至关重要。许多学者对微种植体支抗的初期稳定性进行了临床及试验研究。该文就影响微种植体支抗初期稳定性的因素进行综述。

  18. 微型种植体支抗用于口腔正畸治疗中的效果观察%Effect of Mini Implant Anchorage for Orthodontic Treatment

    Institute of Scientific and Technical Information of China (English)

    王海

    2015-01-01

    Objective To observe the effect of the application of Micro Implant Anchorage in orthodontic treatment. Methods 70 cases of patients were selected, according to the method of random number will be the into the observation group and the control group and observation group with micro implant body anchorage in the treatment and control group treated by routine method and compared between the two groups effect. Results The observation group molar displacement, the upper central incisors angle difference and the difference between the upper central incisors and the central incisors were superior to the control group, and the incidence of adverse reactions was lower than the control group (P<0.05). Conclusion The application of Micro Implant Anchorage in orthodontic treatment is remarkable.%目的:观察在口腔正畸治疗中微型种植体支抗的应用效果。方法选取接受正畸治疗的患者70例,根据数字随机法将其分为观察组与对照组,观察组采用微型种植体支抗治疗,对照组采用常规方法治疗,比较两组疗效。结果观察组磨牙移位、上中切牙倾角差以及上中切牙凸距差等方面均优于对照组,且不良反应发生率低于对照组(P<0.05)。结论口腔正畸治疗中微型种植体支抗的应用效果显著。

  19. Study on Structural Forms of External Prestressing Anchorage for a Novel Continuous UHPC Box-girder Bridge%新型UHPC连续箱梁桥的体外预应力锚固构造形式研究

    Institute of Scientific and Technical Information of China (English)

    邵旭东; 张良; 张松涛; 欧阳泽卉

    2016-01-01

    针对新型UHPC连续箱梁桥的结构特点及预应力体系布置,对其腹板处体外预应力下折索进行齿块锚固研究。对独立矩形齿块进行应力分析,揭示板厚对锚固区壁板外侧“局部弯曲效应”的影响。通过拓扑优化分析构建出一个揭示齿块锚固区传力机理的简化平面杆系模型,提出两种齿块锚固区局部加强的方法。在此基础上,对UHPC箱梁桥的腹板体外预应力锚固齿块进行构造设计,对比6种不同锚固方案,分析横隔板、预应力筋齿块内转向和锚固长度对锚固区受力的影响,最终得出较为合理的体外预应力齿块锚固构造形式。%According to the characteristics of a novel continuous UHPC box-girder bridge and the lay-out of its prestressing system,the anchor block for external tendons on the web was studied.Firstly,the effect of the plate thickness on the“local bending effect”in anchorage zone was evaluated through the anal-ysis of stress in the isolated rectangular anchor block.A simplified plane linkage model was proposed through the topology optimization in order to study the force transfer mechanism in anchorage zone.More-over,two kinds of methods were developed to strengthen the anchorage zone based on the simplified mod-el.On the basis of the above research procedure,six different anchoring schemes of the anchor block for the external tendons were designed.After analyzing and comparing the performance of the different ancho-ring schemes,the effects of diaphragms,steering of prestressing tendons,and anchoring length of the an-chor block on the mechanical behavior of the anchorage zone were evaluated.Finally,a type of reasonable anchor block of the external tendons was obtained.

  20. Caracterização de mini-implantes utilizados na ancoragem ortodôntica Characterization of the mini-implants used to orthodontic anchorage

    Directory of Open Access Journals (Sweden)

    Luciana Rougemont Squeff

    2008-10-01

    Full Text Available INTRODUÇÃO: o diâmetro reduzido do mini-implante, e a decorrente facilidade na sua inserção, minimizam a possibilidade de erro do operador e de contato entre a rosca do mini-implante e a raiz dentária. Entretanto, o risco de fratura da peça aumenta à medida que seu diâmetro é diminuído. MÉTODOS: neste trabalho foram analisados quatro produtos de marcas nacionais (INP, SIN, Conexão e Neodente e um de marca alemã (Mondeal, com o objetivo de identificar características importantes para o bom desempenho deste recurso como acessório de ancoragem. Foram observados composição e design das peças e realizado o ensaio mecânico de torque até a fratura (estudo in vitro, cujos valores foram submetidos à análise de variância (ANOVA e teste de Tukey. RESULTADOS: os resultados mostraram que todos os mini-implantes testados estão aptos à utilização clínica como reforço de ancoragem ortodôntica.INTRODUCTION: The reduced diameter of the mini-implants and the simplicity of the technique could minimize the operator mistake's possibility and avoid the contact between the thread of the screw and the dental root. In spite of that, it increases the fracture risk because of the diameter's decrease. METHODS: At the present work, mini-implants from five different trade marks, four Brazilian systems (INP, SIN, Conexão and Neodente and a German system (Mondeal were studied to identify important characteristics of this anchorage accessory, like composition, design and resistance to the insertion torque (in vitro. The values obtained from the mechanical torque test were submitted to variance analysis (ANOVA and Tukey's test. RESULTS: All studied groups presented good results and are recommended to orthodontic clinic use.

  1. Inhibition of Anchorage-Independent Proliferation and G0/G1 Cell-Cycle Regulation in Human Colorectal Carcinoma Cells by 4,7-Dimethoxy-5-Methyl-l,3-Benzodioxole Isolated from the Fruiting Body of Antrodia camphorate

    Directory of Open Access Journals (Sweden)

    Hsiu-Man Lien

    2011-01-01

    Full Text Available In this study, 4,7-dimethoxy-5-methyl-l,3-benzodioxole (SY-1 was isolated from three different sources of dried fruiting bodies of Antrodia camphorate (AC. AC is a medicinal mushroom that grows on the inner heartwood wall of Cinnamomum kanehirai Hay (Lauraceae, an endemic species that is used in Chinese medicine for its anti-tumor and immunomodulatory properties. In this study, we demonstrated that SY-1 profoundly decreased the proliferation of human colon cancer cells (COLO 205 through G0/G1 cell-cycle arrest (50–150 μM and induction of apoptosis (>150 μM. Cell-cycle arrest induced by SY-1 was associated with a significant increase in levels of p53, p21/Cip1 and p27/Kip1, and a decrease in cyclins D1, D3 and A. In contrast, SY-1 treatment did not induce significant changes in G0/G1 phase cell-cycle regulatory proteins in normal human colonic epithelial cells (FHC. The cells were cultured in soft agar to evaluate anchorage-independent colony formation, and we found that the number of transformed colonies was significantly reduced in the SY-1-treated COLO 205 cells. These findings demonstrate for the first time that SY-1 inhibits human colon cancer cell proliferation through inhibition of cell growth and anchorage-independent colony formation in soft agar. However, the detailed mechanisms of these processes remain unclear and will require further investigation.

  2. Construction Technique of Dragging Stay Cables with Parallel Steel Wire Strands into Anchorages for the Second Jiujiang Changjiang River Bridge%九江二桥平行钢丝斜拉索牵引入锚施工技术

    Institute of Scientific and Technical Information of China (English)

    吴小斌; 杜俊; 李东辉

    2014-01-01

    The main bridge of the Second Jiujiang Changjiang River Bridge is a two-pylon six-span asymmetrical hybrid girder cable-stayed bridge with a main span of 818 m and with double ca-ble planes .The stay cables are composed of the φ7 mm parallel steel wires ,each having a nominal tensile strength of 1 670 MPa .By the comparative analysis of the dragging construction techniques of dragging carried out by hoisters ,soft dragging ,strong dragging and a combination of the two , it was determined to drag the stay cables via a combined application of the above dragging tech -niques ,taking into consideration of the facts that the stay cables are very heavy and long and the difference between the cable forces in the central span and the side spans are great .According to the actual characteristics of the construction ,the auxiliary facilities for the stay cables installation were prepared ,including lifting portal mounted on pylon tops and the platform used to drag the ca-bles into the anchorages on the girder ,by which the problems of the insufficient hoisting capacity and the difficult installation of the dragging devices were resolved .To improve the efficiency of stay cable installation ,the short cables were installed by the steel strand elongation method ,effec-tively reducing the dragging force in the pressing anchorages in the girder and accelerating the speed of the cable′s entering into the anchorages in the girder .The long cables were dragged into the anchorages by the soft dragging and combined application of the aforementioned methods ,re-solving the difficulty of dragging the long cables into the anchorages in the girder .%九江二桥主桥为主跨818 m 的六跨不对称双塔双索面混合梁斜拉桥,斜拉索采用平行钢丝斜拉索,钢丝直径7 mm ,抗拉强度标准值1670 MPa 。通过对卷扬机牵引、软牵引、硬牵引及软硬组合牵引等牵引施工工艺的对比分析,结合该桥的斜拉索超重超长、中边跨索

  3. Application progress of orthodontic treatment with titanium miniplate anchorage system%微钛板种植支抗在口腔正畸临床中应用进展

    Institute of Scientific and Technical Information of China (English)

    宁召亮(综述); 刘琳(审校)

    2013-01-01

    种植支抗作为多学科交流融合产物,无疑对正畸临床的诊断与治疗理念产生了巨大影响。从目前国内外对于种植支抗的关注度以及临床应用情况来看,微螺钉种植支抗将成为口腔正畸种植支抗的主要趋势。微钛板种植支抗由于其优势,如脱落率极低、固位钉远离牙根、植入时或牙齿在较大范围内移动时也不会累及牙根、临床加力简单、不依赖于患者的配合程度等,可为多种复杂错牙合畸形提供治疗选择。由于微钛板埋入手术的损伤较大,术后肿胀较明显,术后不良反应给患者带来的恐惧心理以及较高的费用均影响了微钛板支抗在正畸临床上的应用。而组织相容性好、稳定性强、简单、微创、舒适的微钛板种植支抗系统的进一步研究,必将对正畸临床诊断和治疗产生积极深远的影响。%As a product of multidisciplinary combination,the usage of implant anchorage undoubtedly had a great impact on clinical diagnosis and concept of modern orthodontic treatment. From the perspectives of both international and do-mestic interests in the clinical application of orthodontic anchorage,mini-screws anchorage implant would become a sig-nificant trend in this field. However,titanium miniplate anchorage could more efficiently offer a new choice for the treat-ment of complex maxillofacial malformation,because it had plenty of advantages that other methods did not,such as low losing ratio,retentive pin far away from tooth roots,easy applying force operation for orthodontists,tooth roots barely in-volved during implantation or obvious tooth movement,and being less dependent on patients' compliance. Inevitably, there were also several drawbacks restricting its clinical application,including the possibility of severe surgical injury, significant swelling after implantation,patients' great fear caused by side-effects and higher surgery cost. But one thing is certain

  4. Mini-implant Anchorage in Orthodontic Treatment Nursing Intervention%微型种植支抗在口腔正畸治疗中的护理干预

    Institute of Scientific and Technical Information of China (English)

    龚晓琳

    2014-01-01

    Objective To summarize the micro-implant anchorage methods and ef ects of nursing interventions in orthodontic treatment. Methods Our hospital in January 2012-2013 February malocclusion treated 45 patients were given orthodontic mini-implant anchorage surgery before and after surgery have implemented measures to improve nursing intervention period was 14 days. Patient satisfaction through 9 Surgical cosmetic surgery orthodontic clinical data analysis. Results After the intervention ef ective in 34 cases, ef ective in 11 cases, the ef ective rate was 100.0%, with no serious complications and at achment loss occurs. After 14 days in patients with plaque index increased significantly, while the probing depth decreased with preoperative contrast significantly dif erent ( <0.05). Conclusion The mini implant anchorage in orthodontic treatment applied to ef ectively improve the appearance of the mouth and chewing function, but also the need to strengthen nursing intervention.%目的:总结微型种植支抗在口腔正畸治疗中的护理干预方法与效果。方法选择我院正畸科2012年1月~2013年2月收治的错颌畸形患者45例,都给予口腔正畸微型种植支抗手术治疗,在手术前后都实行了完善的护理措施,干预周期为14d。通过对患者进行临床资料分析。结果干预后显效34例,有效11例,有效率为100.0%,无严重并发症与附着丧失发生。术后14d患者的菌斑指数明显下降,而探诊深度明显下降,与术前对比差异明显(<0.05)。结论微型种植支抗在口腔正畸治疗中的应用有效改善了口腔美观及咀嚼功能,但是也需要加强护理干预。

  5. Combination application of implant and mini-screw implant as anchorage in orthodontic and renovation%种植体和微型种植体支抗在正畸与修复中的联合应用

    Institute of Scientific and Technical Information of China (English)

    武秀萍; 李冰; 冯云霞

    2013-01-01

    目的:探讨种植体和微型种植体支抗在正畸与修复中的联合应用的可行性,并观察临床效果。方法:选择24例下颌磨牙缺失对牙伸长需要做种植的患者。缺牙区植入ITI种植体,常规种植治疗。同时在对伸长的磨牙的近中腭侧和远中颊侧各植入一枚微型种植体,用橡皮链挂在颊、腭侧的种植体上,以压低伸长的对牙齿,定期更换并进行临床检查。结果:24例患者中,1枚微型种植钉松动脱落,余23例患者伸长牙平均压低2.4mm,平均压低时间为5.6个月,经种植修复后均获得满意的临床效果。结论:针对下颌磨牙缺失对牙伸长的病例,种植体和微型种植体支抗的联合应用,能达到最佳的修复效果。%Objective: To evaluate the clinical effects of combination application of implant and mini-screw implant as anchorage in orthodontic and renovation. Methods: Choose 24 patients who's mandibular molar had defected and maxillary molar had elongated>2.5mm. The patients' mandibular molar defect were received ITI implant installation under the normal treatment rules. At the same time, the extruded maxillary molar were treated with self-drillinng mini-screw implant as anchorage for intrusion. Rusults:1 patient's miniscrew implant were loosed and then lost because of peri-implant inflammation. Other 23 patients' maxillary molar were average intruded 2.4mm in 5.6 month. After ITI implant installed in par-tial edentulous area, the effect of the treatment were excellent. Conclusion: To the patients of mandibular molar defected and maxillary first molar elongated, combination application of implant and mini-screw implant as anchorage in orthodontic and renovation can obtain optimal results.

  6. 碳纤维增强复合材料筋复合型锚具试验研究和有限元分析%EXPERIMENTAL INVESTIGATION AND FINITE ELEMENT ANALYSIS OF WEDGE-BOND ANCHORAGE FOR CFRP-TENDONS

    Institute of Scientific and Technical Information of China (English)

    刘荣桂; 李明君; 刘德鑫; 蔡东升; 谢桂华

    2012-01-01

    In order to colligate the virtue of bonding-anchor and wedge-anchor, the wedge-bond anchorage for CFRP tendons was investigated, which was made by bonding and wedge parts, working in parallel. Based on the characteristics of exiting CFRP tendon anchors and according to a series of static load tests, it was studied the bonding property of colloid, and the influence of bond length, colloids thickness on the performance of straight pipe bonding anchorage. The static load test of wedge-bond anchorage was conducted to investigate its failure mode, ultimate load, slip deformation, etc. Transport mechanism of anchorage stress is preliminarily analysed according to variation of actual stress in the anchorage zone. The influences of variation in specific parameters, such as wedge slope, angular differential, presetting load, on the internal stress of the anchorage were simulated by using finite element method. And the suggested design parameters were offered. Which can provide academic reference for the optimization of wedge-bond anchorage.%为综合粘结型锚具与夹片型锚具各自的优点,在已有碳纤维增强复合材料(简称CFRP)筋锚具的基础上,研究由粘结部分与夹持部分协同工作而成的复合型锚具。由直筒粘结型锚具的静载试验,研究胶体粘结性能,粘结长度、胶体厚度对锚固性能的影响。通过复合型锚具静载试验,研究该类锚具的失效模式、极限荷载、滑移变形等,结合锚固区实测应力变化,初步分析锚固应力的传递机制。通过有限元分析方法,模拟计算夹片倾角、锥角差、预紧力等参数对复合型锚具内部受力的影响,得到建议设计参数,为复合型锚具结构优化提供参考。

  7. 微型种植体骨性支抗在临床的应用研究%The application and research of micro-implant bone anchorage in clinic

    Institute of Scientific and Technical Information of China (English)

    苏丽英; 刘国实; 王松梅; 张宏; 卢晓梅; 陈竟男; 夏国栋; 李光磊

    2011-01-01

    [目的]探讨微型自攻型钛种植体作为骨性支抗在临床正畸工作中的应用及其优、劣势.[方法]20例患者应用48颗微型种植体,用于拉前牙向后,关闭拔牙间隙时植入第2前磨牙与第1磨牙之间牙槽间隔,单侧磨牙缺失时植入第2磨牙的远中,需直立后牙者置于该牙齿的倾斜方向反向颊侧.微型种植体植入后可即刻加力,承受的牵动力为100~200 g.[结果]安氏Ⅱ类骨性上颌突、双颌突病例12例治疗结束后,切牙切缘平均内收6.3~6.4 mm,支抗磨牙平均前移0.3~0.4mm,单侧恒磨牙缺失的病例磨牙支抗前移1.0~1.5 mm,面型均得到明显的改善.安氏I类、安氏Ⅲ类错(牙合)病例的治疗均达到理想效果.[结论]自攻型微钛钉种植体作为骨性支抗具有接触面积小、稳定性强、力量强的优点;种植后即刻加力,缩短了疗程;正畸医师可以独立完成操作,患者也易于接受.%[Objective] To study the self-drilling titanium screw mini-implants as skeletal anchorage in the clinical application of orthodontic work, study its advantages and disadvantages. [Methods] 20 patients treated with 48 micro-implant for anterior teeth pulled back. Implanted at the time extraction space closed second premolar and the first molar alveolar interval, when the unilateral molar implant distal second molar, to be placed upright in the posterior teeth by reversing the direction of tilt of the cheek teeth side. Micro-implants after immediate loading, will affect the force to withstand 100~200 g. [Results] Class II skeletal maxillary protrusion, bimaxillary protrusion cases of 12 patients after treatment, the average margin of incisors adductor 6.3 ~ 6.4 mm, the average molar anchorage forward 0.3 - 0.4 mm, the missing cases of unilateral molar molar anchorage forward 1.0 ~ 1.5 mm, the surface shape were improved obviously. Class I , Class IH malocclusion, are to achieve the desired effect. [Conclusion] The self

  8. 斜拉桥索塔锚固区节段足尺模型试验与分析%Test and analysis on full scale segmental model of cable tower anchorage zone in cable stayed bridge

    Institute of Scientific and Technical Information of China (English)

    郭凡; 杨永清; 周厚斌; 刘国军

    2012-01-01

    A FEM model of the cable tower anchorage zone section in certain cable stayed bridge was built to analyze the spatial stress field,and the values obtained by spatial stress analysis and full scale model test were compared.The evaluation of the operating capability and safety of the bridge tower was brought forward.The frictional coefficient values of the U-shaped plastic corrugated pipes and the extension values of tendons were analyzed.Stress distribution and deformation under U-shaped and small radius ring prestressed tendons and cable force were investigated.Some suggestions about constitution and design were given to similar force analysis of cable tower anchorage zone as references.%对某斜拉桥索塔锚固区节段建立有限元计算模型进行空间应力分析,并与足尺模型试验得出的结果相比较,对该桥塔锚固区工作性能及安全性进行评价。测试分析U形塑料波纹管孔道摩阻系数和钢束伸长值,研究了小半径环向U形预应力束与拉索作用下的锚固区应力与变形情况,提出构造及设计上的建议,为设计与施工提供依据,也可为同类斜拉桥索塔锚固区的受力分析提供借鉴。

  9. STABILITY ANALYSIS OF ANCHORAGE FOR SUPER SUSPENSION BRIDGE OVER LONGJIANG RIVER IN YUNNAN PROVINCE%云南龙江特大悬索桥锚碇稳定性分析

    Institute of Scientific and Technical Information of China (English)

    郭松峰; 祁生文; 李正熔; 马健; 柴建峰; 翟文龙

    2011-01-01

    重力式是悬索桥安全的关键结构之一,其支墩的偏移量对悬索桥的稳定性至关重要.拟建的云南龙江特大悬索桥保山岸地层复杂,岩性软弱,地基土力学参数较低.在工程设计中,需预测在施工运行过程中的锚碇支墩偏移量,以合理确定地基是否需要加固处理以及设定加固参数.为此,本文利用FLAC3D按照锚碇基坑开挖、锚碇主体施工、回填及二期构件完成、主缆索连接的施工步骤,依次建立较为精细的数值模型来模拟实际工况.数值分析结果表明:云南龙江特大斜拉桥锚碇保山岸锚碇支墩在回填压重和最大缆力工况下的水平偏移量小于5cm,在允许范围15cm内,锚碇基坑底部沉降量顺桥轴线方向自锚后到锚前逐渐减少,但梯度不大,锚碇略微后倾0.05°,不会发生倾倒翻转,也不需对地基加固.数值计算中发现,岩土参数的取值对计算结果影响有较大影响,为此,作者对变形模量、泊松比、黏聚力、内摩擦角、密度等5个参数进行了敏感性分析.结果表明,在研究区的岩土参数取值范围内,变形模量E敏感度较大,在工程勘察中通过足够的试验合理地确定其值十分重要.%As a style of anchoring the cable of suspension bridge, the gravity anchor is one of the most important elements for the safe of the bridge. The displacement of the anchorage buttress is the key factor for the stability. Thispaper examines the stability of the anchorage for a Super Cable-stayed Bridge planned to be built over Longjiang river in Yunnan Province. It is located in the place with complex stratum condition. The soil strength and modulus parameters are very small at the construction site. Therefore, predicting the displacement of anchorage buttresses under various conditions is very important to design the proposal of foundation treatment and determine treatment parameters reasonably. This paper presents the large-scale numerical models with

  10. 3-D Finite Element Study on Rapid Maxillary Expansion Using Implant Anchorage%腭种植体支抗快速扩弓的三维有限元分析

    Institute of Scientific and Technical Information of China (English)

    潘虹海; 黄跃; 杨正; 杨四维

    2011-01-01

    Objective To evaluate the biomechanic changes of craniofacial complex with rapid maxillary expansion using implant anchorage. Methods Rapid maxillary expansion using implant anchorage was simulated with MSC. Marc. Mentat software, restrained at the region around the foramen magnum and the anterior middle point of parietale and foramen. In the area of implant surface, forces of 80 N were applied with rapid maxillary expansion. Different numbers and positions of implant anchorage were chosen. Their influences on the craniofacial complex were analysed. Results The stress distribution and displacement trend of the craniofacial complex under different conditions were approximate. The greatest stress appeared on the areas along the frontonasal suture, zygomaticomaxillary suture, nasomaxillary suture and pterygopalatal suture. Two halves of palatine were separated in a "V" shape. Maximal stress and displacement were found when the implant was located between maxillary canine and first premolar. Conclusion The numbers of implant are not associated with the size of stress and displacement. Greater stress and displacement occur when the implant position is in the front.%目的 研究不同位置和数目腭种植体支抗在快速扩弓时颅面复合体的生物力学变化,为临床应用腭种植体支抗快速扩弓提供理论依据.方法 应用MSC.Marc.mentat 2005 R3软件,模拟上颌快速扩弓,以枕骨大孔边缘及顶骨、枕骨前部中点作为固定,种植体处施加扩弓力.设定扩弓力大小为80 N,模拟不同位置及数目腭种植体支抗快速扩弓,分析不同加载条件对颅面复合体的影响.结果 不同位置及数目腭种植体支抗快速扩弓时颅面复合体的应力分布和位移趋势较为一致,应力较大区域分布在鼻额缝、颧颌缝、鼻上颌缝、翼腭缝,腭中缝呈“V”形打开,种植体位于上颌尖牙和第一前磨牙之间时相应的应力和位移最大.结论 快速扩弓时腭种植体数目

  11. A study on the stability of miniscrew on different loading time as orthodontic anchorage%不同时机受力对微种植体支抗稳定性的影响

    Institute of Scientific and Technical Information of China (English)

    朱良燕; 严拥庆; 高益鸣

    2011-01-01

    PURPOSE: To evaluate the stability of the miniscrew on different loading time as orthodontic anchorage. METHODS: 2 healthy adult male Beagle dogs were used in this study. 48 mini-implants were implanted into the maxilla and mandible of the dogs. The miniscrews were divided into 8 different groups, 1 group was loaded Og as control group and the others were loaded 200g forces as experimental groups. 200g forces were loaded on the corresponding mini-implant anchorages immediately after implantation and at the time of lw,2w,3w,4w,5w and 6w after implantation. The dogs were sacrificed at 12w after implantation. Histological progresses of implant -bone interfaces was examined with light microscope.Blue deposition and contact ratio were calculated and analyzed using SPSS13.0 software package. RESULTS: Fibrous and osseous-integration was noted in the interface, there was no significant difference in bone deposition ratio and bone contact ratio. CONCLUSION: Different force loading time does not affect the stability of the mini -implant anchorage.Supported by Natural Science Foundation of Shanghai Jiao Tong University School of Medicine(757).%目的:通过对微种植体-骨组织界面的组织形态学分析,研究不同加载时机对微种植体支抗稳定性的影响.方法:全麻下将48枚微型钛金属种植体植入2只实验Beagle犬双侧上、下颌骨,每只24枚.将48枚种植体分为8组,1组为对照组,负载力值为0g;其余7组为加力组,负载力值为200g.加力组分别在植入术后即刻、第1周、第2周、第3周、第4周、第5周和第6周,用正畸专用镍钛螺旋拉簧对各组微种植钉在相应的时间施加200g的水平拉力.在种植钉植入术后的第6周、第8周和第10周,分别对2只实验犬颈部皮下注射荧光剂四环素、土霉素和钙黄绿素溶液.于植入术后第12周处死实验犬,应用光学显微镜及病理图像分析系统对种植体骨磨片进行纵断面观察,并计算各种植植体-骨

  12. A clinical cephalometric study of mini-implant anchorage for en-masse retraction of eight maxillary anterior teeth%微种植体辅助整体内收上前牙段的头影测量

    Institute of Scientific and Technical Information of China (English)

    张华; 麦志辉; 卢红飞; 艾虹; 文冲

    2011-01-01

    目的:研究微种植体支抗在矫治上颌前突病例中整体内收上前牙段的应用.方法:选择5例上颌前突患者,拔除第二前磨牙,采用直丝弓矫治技术,辅以微种植体支抗同时整体内收前牙段(6个前牙及2个第一前磨牙),通过X线头影测量分析,观察矫治前后上颌骨软硬组织的变化.结果:上颌骨的变化轻微;切牙平均内收(4.6±1.5)mm,压低(0.8±1.1)mm,根尖后移(1.7±1.4)mm,切牙与腭平面的夹角减少(6.8±3.5)度;支抗磨牙水平前移(0.5±0.3)mm,没有出现明显的颌向伸长;上唇突度减少(2.0±0.9)mm,鼻唇角增大(3±2.4)度.结论:微种植体能提供稳定的支抗,同时整体内收上前牙段,最大限度避免支抗的丧失,改善上唇突度.%Aim: To Study the efficiency of mini-implants as intraoral anchorage units for en-masse retraction of the 6 maxillary anterior teeth and 2 first premolars after the second premolars are extracted. Methods: Five patients requiring high anchorage after extraction of the maxillary second premolars were selected for this study. Straight wire appliance and mini-implants were used for en-masse retraction, Horizontal , vertical, and angular positions of the maxillary ? Rst molar and central incisor were evaluated ceph-alometrically before and after orthodontic retraction. Results; The edge of upper incisors were retracted (4. 6 ±1. 5)mm and intruded (0. 8 ±1. L)mm, the root apex moved distally (1. 7 ± 1.4)mm. The maxillary first molars showed mesial movement of (0. 5 ±0. 3)mm. The nasolabial angle increased (3 ±2.4)° and the angle between upper incisor and PP-plane decreased (6. 8 ± 3. 5 ) °. Conclusion: Mini-implants are efficient for intraoral anchorage reinforcement for en-masse retraction and intrusion of maxillary anterior teeth.

  13. 微型种植体支抗在口腔正畸治疗中的疗效评价%Clinical efficacy of micro-implant anchorage in orthodontics treatment

    Institute of Scientific and Technical Information of China (English)

    安葵; 万惠子; 肖长芬

    2013-01-01

    Objective To investigate the clinical efficacy of micro-implant anchorage in orthodontics treatment.Methods Eighty-three patients undergoing orthodontics treatment were divided into two groups,including the observation group of 42 patients with micro-implant anchorage anti-treatment and control group of 41 patients with traditional orthodontics treatment.The effects and adverse reactions of the two groups were compared.Results 05) o After treatment,the indicators such as the molar shift,the upper central incisors inclination poor and upper central incisors protrusion distance in the observation group were better than those in the control group,and the differences were statistically significant (P < 0.05).The rate of adverse reactions in the observation group was only 7.14 %,significantly lower than in the control group.The difference was statistically significant (P< 0.05).Conclusion The mini-implant in the treatment of orthodontics is better than traditional orthodontics treatment and it is worthy of wider application.%目的 探讨微型种植体支抗在口腔正畸治疗中的疗效.方法 选择本院收治的接受口腔正畸治疗的患者83例,并随机分为观察组(n=42)和对照组(n=41).观察组给予微型种植体支抗治疗,对照组给予传统正畸方法治疗,比较2组患者的治疗效果和不良反应发生情况.结果 治疗后,观察组磨牙移位、上中切牙倾角差及上中切牙凸距差等指标均明显优于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为7.14%,明显低于对照组的36.59%,差异有统计学意义(P<0.05).结论 微型种植体在口腔正畸治疗中具有较佳的支抗作用,明显优于传统的口腔正畸治疗措施,值得临床推广应用.

  14. The Research of Application of the Looped Prestressed Tendons with Large Tonnage and Small Radius in the Anchorage Zone of Cable-stayed Bridge Tower%大吨位小半径环向预应力在斜拉桥索塔锚固区中的应用研究

    Institute of Scientific and Technical Information of China (English)

    陈建阳; 徐国平; 刘丽; 朱正群

    2001-01-01

    Nowadays the large tonnage and small radius annular prestress system are applied in the anchorage region of large span cable-stayed bridge construction in our country. The application of this system has been a breakthrough of the Design Specification of Highway Bridge and Culvert. In this article, the application of this system applied in the anchorage region of cable-stayed bridge tower has been probed in close connection with the full-scale model test of the anchorage zone of the Wuhan Junshan Changjiang River Bridge.%目前我国大跨径斜拉桥索塔锚固区开始采用大吨位小半径环向预应力体系,该体系突破了现行《公路桥涵设计规范》的规定。结合武汉军山长江公路大桥索塔锚固区足尺模型试验及张拉工艺模型试验对该预应力体系在斜拉桥索塔锚固区中的应用作了深入的探讨。

  15. 施桥船闸下游停泊锚地工程预应力管桩施工工艺%Construction Technology Research on Prestressed Pipe Pile of Shiqiao Shiplock Downstream Anchorage Engineering

    Institute of Scientific and Technical Information of China (English)

    汪萍

    2014-01-01

    Shiqiao Shiplock downstream anchorage engineering soil condition is very poor and the un-derground water level is high.The high strength PHC prestressed pipe pile for reinforcing soft soil foundation is adopted in the project.According to the characteristic condition,the pile sinking tech-nology and the treatment of pile top and bottom connection for prestressed concrete pipe pile are stud-ied.Effective measures to control the position accuracy of pile sinking when pile length up to 6.38m, reduce the surface exposed time and ensure the connection quality of pile top and bottom under the conditions of large excavation in soft soil foundation are performed and good effect has achieved.%针对施桥船闸下游停泊锚地工程现场地质条件,对预应力管桩的沉桩工艺和管桩桩顶与底板的连接处理进行了研究,就送桩长度达6.38 m 如何控制沉桩的位置精度,以及在软土大开挖条件下如何减少地基表层裸露时间,保证桩顶与底板的连接质量,采取了有效措施,取得了良好的效果。

  16. Application value of micro-implant anchorage in orthodontic therapy%微型种植体支抗在口腔正畸治疗中的应用价值

    Institute of Scientific and Technical Information of China (English)

    葛长平

    2016-01-01

    目的:探讨微型种植抗体支抗在口腔正畸治疗中的应用价值。方法选取口腔科门诊2012年4月至2014年7月行正畸治疗患者90例,随机分为两组,每组45例。对照组按照传统方法实施正畸治疗,实验组采用微型种植体开展正畸治疗,对比两组患者的正畸治疗效果及术后并发症的发生情况。结果实验组正畸治疗结束后其上中切牙倾角差、凸距差和磨牙移位情况均明显优于对照组,差异有统计学意义( P<0.05);实验组不良反应的发生率明显低于对照组,差异有统计学意义( P<0.05)。结论微型种植体能够为口腔正畸治疗提供有效的支抗作用,有助于提高正畸治疗的临床效果,安全可靠,建议临床推广。%Objective To investigate the application value of micro-implant anchorage in ortho-dontic therapy.Methods From April 2012 to July 2014, 90 patients with orthodontic treatment were se-lected, and they were randomly divided into two groups , with 45 cases in each group .The control group was given traditional orthodontic treatment methods , the experiment group were conducted with micro-im-plant orthodontic treatment , the effect of orthodontic , and postoperative complications of the two groups were compared.Results After the end of the orthodontic treatment , the inclination poor, poor and teeth protruding from the shifting of the patients in experiment group were significantly better than those in con-trol group , the differences were significant ( P<0.05 );The incidence of adverse reactions in patients of experiment group was significantly lower than that of control group , the difference was significant ( P<0.05 ) .Conclusions Mini implants can provide effective treatment for orthodontic anchorage , help to improve the clinical effectiveness of orthodontic treatment , and it is safe and reliable , so it is recommen-ded to further promote in clinical practice .

  17. Experimental Research on Stress Behavior of Stud Shear Connector in Tower Anchorage Area of Cable-stayed Bridge%斜拉桥锚固区栓钉剪力键力学特性研究

    Institute of Scientific and Technical Information of China (English)

    吴秀发; 张小亭

    2014-01-01

    针对栓钉剪力键用于斜拉桥索塔锚固区连接部位时的应力应变特性,以中部横梁均匀加载为思路,建立局部试验模型,以栓钉剪力键的极限承载力为依据,设计加载方案,通过试验获取栓钉的应变随荷载变化的基本特征,并分析了破坏机理。结果表明:中部加载使模型两侧剪力键受力均匀,设计更为合理;栓钉剪力键的剪应力以加载梁为中心向两侧逐渐降低;高度方向,第7排栓钉受力最大,长度方向,单钉根部受到的剪力最大,应作为控制截面;破坏时,栓钉弯曲变形,根部发生45°剪切破坏,混凝土局部产生裂缝或压碎破坏。%This article mainly studied the stud shear connector for anchorage zone of pylon cable-stayed bridge connecting parts when subject to stress-strain characteristics.Taking central uniform load for ideas established local test model.Loading program was designed which based on the ultimate bearing ca-pacity of stud shear connector.It has acquired the basic characteristics of stud strain with load variation and analyzed the failure mechanism.The results showed that:The model adopts central loaded design is more reasonable because it makes shear connector force uniform on both sides of the model.The shear stress of stud shear connector decreased gradually from the center to both ends of the load beam.In the height direction,the 7th rows of pegs subject the maximum shear stress.In the longitudinal direction,sin-gle nail roots subject the maximum shear stress.It should be used as the control section.When the stud destruction,the stud bending deformation occurs,peg roots shear failure in direction of 45 °,the partial concrete will produce cracks or be crushed.

  18. Comparative study of clinic effects of segmental archs and mini-implants for orthodontic anchorage on orthodontic canine distalization%片段弓与微种植体支抗拉尖牙向远中的临床应用对比研究

    Institute of Scientific and Technical Information of China (English)

    徐晓静; 沈云娟; 秦燕军

    2012-01-01

    Objective To compare the clinic effects of segmental archs and mini-implants for orthodontic anchorage on orthodontic canine distalization. Methods 60 cases of dental crowding, whose four first premolars were extracted and canine distalization was needed according to the treatment protocol, were randomly divided into 2 groups. Mini-implants were used in the cases in experimental group as orthodontic anchorage to move canine distally, and segmental archs were used in the control cases. The distances of canine dis-talizalion and the angles of anchorage molar inclination in 60 cases were measured and compared. Results The mean velocity of canine distalizalion in the experimental group was (1.428 ±0.072) mm/month,which was faster than(l. 137 ±0.081)mm/month in the control group. The degree of molar inclination (1.27 ±0.18) in the experimental group was less than that in the control group (1.91 ±0.13). Statistic analysis showed that there were significant differences. Conclusions The mini-implants for orthodontic anchorage can move the canine faster and control the anchorage molar better than the segmental arch.%目的 比较片段弓技术和微种植体支抗在拉尖牙向远中的临床应用效果.方法 60例牙列拥挤,双侧对称拔除第一前磨牙且需将尖牙拉向远中的患者,随机分为2组,试验组尖牙远移时应用微种植体作为支抗,对照组则使用片段弓技术远移尖牙,测量尖牙向远中移动的距离以及磨牙近中倾斜的程度.结果 试验组尖牙移动的速率为(1.428±0.072)mm/月,快于对照组(1.137±0.081)mm/月;试验组磨牙近中倾斜程度为(1.27±0.18)°,小于对照组(1.91±0.13)°.经统计学检验差异均有显著性(P<0.05).结论 使用微种植体支抗拉尖牙向远中在牙齿移动速率以及控制磨牙近中倾斜等方面优于片段弓技术.

  19. Rapid Maxillary Expansion without Posterior Anchorage.

    Science.gov (United States)

    Oliveira, Adauê; Amaral, Cássia

    2016-01-01

    This work aimed to evaluate an alternative form of maxillary expansion anchored with mini-implants. A patient 12 years, class III in permanent canine teeth, with multiple agenesis of upper posterior teeth was treated with the aid of four mini-implants in the palate and Haas modified type appliance. During the period of expansion, an interincisal diastema was observed as the first clinical sign of disjunction of the sutures. After correction of cross bite, the expansion of the palate was confirmed by upper occlusal radiographs. Thus, the evaluations showed that the technique was effective and that new scientific studies should be conducted to further develop this subject. Keywords: Appliances; Biomechanics; Implants; Malocclusions PMID:27319047

  20. Annual game report, Anchorage district, 1955

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Facilities, personnel, equipment, funds, communications, patrol activities, record of travel, cooperative activities, and game law violations.

  1. 76 FR 52599 - Anchorage Regulations; Wells, ME

    Science.gov (United States)

    2011-08-23

    ... Federal Register (73 FR 3316). Public Meeting We do not now plan to hold a public meeting. But, you may... Wells, Maine. All coordinates referenced use datum: NAD 83. Dated: Aug. 9, 2011. Daniel A. Neptun,...

  2. 77 FR 6010 - Anchorage Regulations; Newport, RI

    Science.gov (United States)

    2012-02-07

    ...; Newport, RI'' in the Federal Register (76 FR 59596). We received no comments on the proposed rule. Basis.... * * * * * Dated: January 20, 2012. Daniel A. Neptun, Rear Admiral, U.S. Coast Guard, Commander, First Coast...

  3. 76 FR 59596 - Anchorage Regulations; Newport, RI

    Science.gov (United States)

    2011-09-27

    ... FR 3316). Public Meeting We do not now plan to hold a public meeting. But, you may submit a request...) of this section. * * * * * ] Dated: September 13, 2011. Daniel A. Neptun, Rear Admiral, U.S....

  4. 爆炸荷载下不同锚固参数围岩的加速度响应分析%Acceleration response analysis of surrounding rock with different anchorage parameters subjected to explosive loads

    Institute of Scientific and Technical Information of China (English)

    杨自友; 杨本水; 顾金才; 李永池; 高光发

    2011-01-01

    If acceleration of rock mass is too large, the surrounding rock of underground cavern is not stable.By analyzing time-history curves of acceleration obtained by model test, the acceleration response characteristics of surrounding rock with different anchorage parameters in underground cavern subjected to explosive loads are studied.The forms and peak values of the time-history curves of acceleration of underground cavern's crown, floor and two sides are explained respectively.Because of the different reinforcing modes, the distinctions of the acceleration response of surrounding rock of underground cavern are compared emphatically.The results indicate that the time-history curves of the vertical acceleration of crown and the horizontal acceleration of floor right side are smooth enough; but the vibration of the time-history curves of the vertical acceleration of floor and the left side are larger than the others.The acceleration of the crown is the largest than the other positions.For the cavern of the smallest spacing of rock bolts in four underground caverns, the acceleration of its crown and two sides is smaller than the other caverns; but the acceleration of its floor is larger slightly than the others'.By means of comparing and analyzing above, reducing the spacing of the rock bolts can enhance the stabilization of underground cavern.%地下洞室岩体加速度过大易造成围岩的不稳定,通过由模型试验得到的加速度-时程曲线分析,研究了爆炸荷载作用下不同锚固参数洞室围岩的加速度响应特征.分别阐述了洞室拱顶、底板、两帮加速度时程曲线的形态及其峰值大小,重点比较了洞室围岩因锚杆加固方式的不同对爆炸产生加速度响应的差异,结果表明,拱顶垂直和右帮水平加速度-时程曲线较光滑,而底板和左帮垂直加速度-时程曲线存在较大震动;洞室拱顶加速度峰值最大;4个洞室中锚杆间距最小的洞室,其拱项、两帮加速度

  5. Factors influencing the stability of miniscrew implants as orthodontic anchorage%影响微螺钉支抗种植体稳定性的相关因素

    Institute of Scientific and Technical Information of China (English)

    季清皎; 刘忠汉

    2013-01-01

    目的:探讨影响微螺钉种植体作为支抗植入后的稳定性相关因素。方法:回顾性分析在44名患者中植入的100枚微螺钉种植体,临床因素包括患者的性别、年龄,负载的时间,微螺钉的大小,种植的部位。结果:种植成功率为83.0%。即刻负载种植成功率为94.4%明显高于延期负载种植成功率的76.6%,有统计学差异(P<0.05)。直径1.6mm螺钉种植成功率为93.0%,直径2.0mm螺钉种植成功率为75.4%,两者比较P<0.05。上颌种植成功率为91.7%,下颌种植成功率为75.0%,两者比较P<0.05。结论:微螺钉支抗种植体稳定性跟种植部位、种植螺钉的大小以及种植后负载的时间有关,而跟性别、年龄以及牙弓内左右侧、前部后部无关。%Objective: To investigate the factors influencing the stability of miniscrew implants as orthodontic anchorage. Methods: In this retrospective study, the records of 100 miniscrews inserted in 44 patients were evaluated. The clinical variables evaluated included the gender and age of patients, the time of load application, the size of miniscrews, the screw location in the bone. Result:The overall success rate in this study was 83.0%. The success rate of immediate loading was 94.4%, significantly higher than the success rate of delayed loading which was 76.6%(P<0.05). The success rate of 1.6mm-diameter miniscrew implants was 93.0%and the success rate of 2.0mm-diameter miniscrew implants was 75.4%, respectively(P<0.05). In case of miniscrew implants in maxilla, the rate was 91.7%, while for miniscrew implants in mandible, it was 75.0%, with the difference of P<0.05. Conclusion: The stability of mini-screw implants is related to the location in the bone, the sizes of miniscrews and the time of load appli-cation, rather than the gender and age of patients; the left and right side, the anterior and posterior in dental arch were not affected the stability.

  6. CLINICAL EFFECTS OF DEPRESSING EDENTULOUS AREA WITH MICRO -SCREW IM-PLANT ANCHORAGE COMBINED WITH SEGMENTAL ARCH TECHINIQUE ON POSTERI-OR TEETH IN ELONGATED JAW%应用微螺钉种植体支抗联合片段弓技术压低缺牙区对颌伸长后牙的临床探讨

    Institute of Scientific and Technical Information of China (English)

    张金望

    2015-01-01

    Objective To study the application of micro -screw implant anchorage combined with segmental arch technique on posterior teeth in elongated jaw to depress edentulous area.Methods 29 adult patients with 31 posterior teeth were depressed with micro -screw implant as skeletal anchorage combined with segmental arch tech-nique in order to help restoration.Results 31 posterior teeth in the experimental group were successfully depressed to the occlusal plane with micro -screw implant anchorage combined with segmental arch technique in order to create restoration space in edentulous area with an average course of treatment of 10 months.29 posterior teeth in the control group were grinded and given root canal therapy to create restoration space in edentulous area.Conclusion The ap-plication of micro -screw implant anchorage combined with segmental arch technique on posterior teeth in elongated jaw to depress edentulous area is an effective straightening method, whereas grinding is the last resort in creating res-toration space in edentulous area.Because patients in primary hospitals have relatively low oral health awareness, some hope for faster and easier solutions and find it difficult to accept traumatic micro -screw implant.%目的:研究微螺钉种植体支抗联合片段弓技术在压低缺牙区对颌过长后牙中的应用。方法使用微螺钉种植体作为骨性支抗联合片段弓技术对29例成人患者共31颗后牙进行压低,以利于修复。结果实验组微螺钉种植体联合片段弓技术31颗后牙均成功压低至咬合平面,为对颌缺牙区开辟修复空间,平均疗程10个月。对照组29颗后牙采用调磨对颌牙后根管治疗的方法为缺失牙开辟空间。讨论使用微螺钉种植体支抗联合片段弓技术压低缺牙区对颌伸长后牙,为缺牙区开辟空间,是一种有效的矫治方法。而调磨对颌牙为缺失牙开辟空间的方法在基层实为不得已而为之。因为基层医院

  7. Effect of Low Bone Metabolic Rate on the Stability of Immediate Loading Micro-Implant Anchorage in Rats%低骨代谢率对微型种植支抗即刻负载稳定性的影响

    Institute of Scientific and Technical Information of China (English)

    张彬; 李冠娥; 李金源; 廖囡囡; 刘蓉艳

    2011-01-01

    目的:研究在低骨代谢率情况下,即刻负载微型种植体支抗的可行性及稳定性.方法:健康Wistar雌性大鼠20只,随机分成2组,每组10只.低骨代谢组(甲减组)给予0.1%丙基硫氧嘧啶;对照组给予蒸馏水,2组均按10μL/g体质量每天灌胃.28 d后植入微型种植体并加力0.98 N,分别于加力后第16、17、26、27天进行标记,加力后30d处死动物.通过X线片测量种植体骨内移动间距;荧光显微镜、光镜下观察含种植钉超硬组织切片并计算骨矿化沉积率、骨结合率.结果:造模后甲减组血清三碘甲状腺原氨酸(T3)、甲状腺素(T4)水平低于对照组,而促甲状腺激素(TSH)则显著高于对照组,甲减组种植体骨内移动间距、骨矿化沉积率及骨结合率均低于对照组.结论:低骨代谢率对微型种植体稳定性有显著影响,低骨代谢情况下微型种植体即刻负载是可行的.%Objective : To investigate the effect of the low bone metabolic rate on the feasibility and stability of immediate loading micro-implant anchorage. Methods : Twenty healthy female Wistar rats were randomly divided into two groups,namely hypothyroid group and control group. There were 10 rats in each group. Rats of hypothyroid group were given intragastrically 10 μL/g, 0.1% propylthiouracil, and rats in control group were given intragastrically distilled water in the same manner for 28 days. Then micro-screws were implanted and 0.98 N force was loaded to all rats. After loaded 16 d, 17 d, 26 d and 27 d, rats were marked by tetracycline and calcein. All rats were killed after loaded 30 days. The mobile space was measured by X-ray. Super-hard nail tissue sections containing plant were observed under fluorescence microscopy and light microscopy. The bone mineral deposition rate and bone contact ratio were calculated. Results: The serum levels of T3 and T4 were lower in hypothyroid group than those of control group, but the level of TSH was significantly

  8. 微型种植体支抗压低犬切牙移动过程中牙周牙根骨性组织的变化%Histological changes of tooth root and periodontal tissue during mini-implant anchorage for incisor intrusion in dogs

    Institute of Scientific and Technical Information of China (English)

    葛振林; 卢嘉静; 祁涛; 田佳灵; 杨彩霞

    2011-01-01

    BACKGROUND: Tooth intrusion easily leads to root resorption. Previous studies regarding orthodontic treatment-caused tooth root resorption or retrospective clinical studies based on X-ray films have great errors in outcome evaluation because of intrusion force which cannot be precisely controlled. OBJECTIVE: This study established dog models of mini-implant anchorage for incisor intrusion to observe the histological changes of tooth root and periodontal tissue and to evaluate the feasibility and safety of mini-implant anchorage for incisor intrusion. METHODS: Nine dogs were assigned to one control group (n = 1) and four experimental groups per time to sacrifice (1, 2, 4 and 12 weeks; n = 2 dogs for each experimental group). No force was added to the control group. In the experimental groups, mini-implant as an anchorage was placed in the buccal alveoli between maxillary second and third incisors on each side. A traction force of 100 g was imposed to each side to intrude the maxillary first and second incisors on each side. At 1, 2, 3, and 4 weeks (traction force was imposed for 4 weeks and after withdrawal of extraction force, mini-implant was retained in place for 8 weeks), dogs were sacrificed. The first and second incisors together with gingival and alveolar bone were completely resected to prepare histological specimens. Following hematoxylin-eosin staining, histological changes of tooth root and periodontal tissue were observed. RESULTS AND CONCLUSION: Compared with the control group, in the 1-week group, histological changes were primarily at the root tip and alveolar ridge crest, alveolar bone and cementum were absorbed and peridental membrane presented glassy degeneration in local region; in the 2-week group, bone resorption degree and range were obviously enlarged, and bone resorption developed from root tip, root middle part to cervical part; in the 4-week group, bone resorption was still active and the glassy degeneration of peridental membrane

  9. 微型种植体支抗辅助牵引成骨重建上颌骨部分缺损的效果评估%Mini-screw implant anchorage-assisted distraction osteogenesis for reconstruction of partial maxillary defect

    Institute of Scientific and Technical Information of China (English)

    冯贻苗; 沈国芳; 房兵; 毛丽霞; 娄新田

    2009-01-01

    PURPOSE:To evaluate the usefulness of self-made distraction osteogenesis instrument by orthodontic technique and mini-screw implant anchorage-assisted distraction osteogenesis(DO) to reconstruct partial maxillary defects. METHODS: Eight patients suffering from partial maxillary defects were selected. Their ages ranged from 19 to 43 years and the average age was 33.2 years. There were 5 males. After a special instrument was fabricated, elastic force trifocal distraction was performed by mini-implant borne aneborage. Three months later the implants were implanted in the two distracted region and the prosthetic restorations were finished finally. RESULTS: In the areas of distraction osteogenesis, ossifications were fine and alveolar bones were completed. The partial maxillary defects were repaired with the implant technique and the prosthodontie technique, and favourable occlusion was obtained. CONCLUSION: Combined orthodontic and DO techniques can reconstruct partial maxillary defect successfully and restore the complicated anatomical contour of the maxilla, especially the dental-alveolar bone.%目的:评价正畸技术自制牵引成骨装置及微型种植体支抗辅助弹力牵引重建上颌骨部分缺损的疗效.方法:选择5例上颌骨部分缺损病例,均为男性,年龄19~43岁,平均33.2岁.制作特殊的牵引装置.采用微型种植体支抗辅助支持的弹力牵引方式,进行三焦点式牵引成骨.3个月后,在两侧牵引区植入种植体,进行牙列修复.结果:骨缺损区牵引成骨后成骨良好,形成完整的牙槽嵴,可应用种植和托牙技术进行牙列修复,恢复良好的咬合关系.结论:对上颌骨部分骨缺损病例,可应用正畸技术和牵引成骨技术联合治疗,以恢复颌骨复杂的解剖结构,尤其是牙槽嵴,为牙列修复提供必备的条件.

  10. Mechanical anchorage of FRP tendons – A literature review

    DEFF Research Database (Denmark)

    Schmidt, Jacob W.; Bennitz, Anders; Täljsten, Björn;

    2012-01-01

    High tensile strength, good resistance to degradation and creep, low weight and, to some extent, the ability to change the modulus of elasticity are some of the advantages of using prestressed, unidirectional FRP (Fibre Reinforced Polymer) tendon systems. Bonded and non-bonded versions of these s...

  11. DIGITAL FLOOD INSURANCE RATE MAP DATABASE, ANCHORAGE, ALASKA, USA

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — FEMA Framework Basemap datasets comprise six of the seven FGDC themes of geospatial data that are used by most GIS applications (Note: the seventh framework theme,...

  12. Process entanglement as a neuronal anchorage mechanism to rough surfaces

    International Nuclear Information System (INIS)

    The organization of neurons and glia cells on substrates composed of pristine carbon nanotube islands was investigated using high resolution scanning electron microscopy, immunostaining and confocal microscopy. Neurons were found bound and preferentially anchored to the rough surfaces; moreover, the morphology of the neuronal processes on the small, isolated islands of high density carbon nanotubes was found to be conspicuously curled and entangled. We further demonstrate that the roughness of the surface must match the diameter of the neuronal processes in order to allow them to bind. The results presented here suggest that entanglement, a mechanical effect, may constitute an additional mechanism by which neurons (and possibly other cell types) anchor themselves to rough surfaces. Understanding the nature of the interface between neurons and carbon nanotubes is essential to effectively harness carbon nanotube technology in neurological applications such as neuro-prosthetic and retinal electrodes.

  13. Metabolism Kinetics of Glucose in Anchorage-dependent Cell Cultures

    Institute of Scientific and Technical Information of China (English)

    孙祥明; 张元兴

    2001-01-01

    The kinetic model of glucose metabolism was established and successfully applied to batchcultures of rCHO and rBHK cells. It was found that a large amount of glucose was utilized for cellmaintenance, and the overwhelming majority of maintenance energy from glucose was by its anaerobicmetabolism in both rBHK and rCHO cell cultures. The overall maintenance coefficients from aerobicmetabolism were 1.9×10-13 mmol/(cell.h) for rCHO cells and 7×10-13 mmol/(cell.h) for rBHK cells. Inaddition, all Go/T and Eo/T gradually increased with the same trend as the cell growth in the culture ofboth rCHO and rBHK cells. The overall molecule yield coefficients of lactate to glucose were 1.61 for rCHO cells and 1.38 for rBHK cells. The yield coefficients of cell to glucose were 4.5×108 cells/mmol for rCHO cells and 1.9 × 108 cells/mmol for rBHK cells, respectively.

  14. Transfer and anchorage bond behaviour in self-compacting concrete

    OpenAIRE

    Rigueira-Víctor, J. W.; Arbeláez, C. A.; Serna-Ros, P.; Martí-Vargas, J. R.

    2006-01-01

    Self-compacting concretes (SCC) provide solutions to the problems facing precast concrete construction, enhancing competitiveness, reducing turnaround times and improving final product quality. SCC is fast becoming a key product for the future development of the precast pre-stressed concrete industry.The present paper compares the bond performance of SCC and traditional concrete (TC). The bond performance results confirm the viability of SCC in precast pre-stressed concrete manufacture, despi...

  15. Process entanglement as a neuronal anchorage mechanism to rough surfaces

    Science.gov (United States)

    Sorkin, Raya; Greenbaum, Alon; David-Pur, Moshe; Anava, Sarit; Ayali, Amir; Ben-Jacob, Eshel; Hanein, Yael

    2009-01-01

    The organization of neurons and glia cells on substrates composed of pristine carbon nanotube islands was investigated using high resolution scanning electron microscopy, immunostaining and confocal microscopy. Neurons were found bound and preferentially anchored to the rough surfaces; moreover, the morphology of the neuronal processes on the small, isolated islands of high density carbon nanotubes was found to be conspicuously curled and entangled. We further demonstrate that the roughness of the surface must match the diameter of the neuronal processes in order to allow them to bind. The results presented here suggest that entanglement, a mechanical effect, may constitute an additional mechanism by which neurons (and possibly other cell types) anchor themselves to rough surfaces. Understanding the nature of the interface between neurons and carbon nanotubes is essential to effectively harness carbon nanotube technology in neurological applications such as neuro-prosthetic and retinal electrodes.

  16. DIGITAL FLOOD INSURANCE RATE MAP DATABASE, MUNICIPALITY OF ANCHORAGE, ALASKA

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — The Digital Flood Insurance Rate Map (DFIRM) Database depicts flood risk information and supporting data used to develop the risk data. The primary risk...

  17. FRP tendon anchorage in post-tensioned concrete structures

    DEFF Research Database (Denmark)

    Schmidt, Jacob Wittrup; Täljsten, Björn; Bennitz, Anders; Henning, Pedersen

    Strengthening of building structures by the use of various external post-tensioning steel tendon systems, is known to be a very efficient method. However, FRP as material in external post-tensioning projects has been investigated during the last decade. The advantages for this material are the high...

  18. The North sea, one of the group's anchorage points

    International Nuclear Information System (INIS)

    The North Sea is one of the pillars of the Elf Aquitaine group's Exploration-Production strategy. The most recent start-up in the North Sea, last february, concerned the Froy field where Elf Petroleum Norge (AS) is an operator with a 24.573 % interest alongside Statoil, Total Norge AS (15.2346 %) and Norsk Hydro. The first gas sales occurred on June 15, as scheduled. The oil production marketed by Elf (net of royalties) remained stable at 13.9 Gm3. At january 1,1995, Elf Aquitaine's mining area covered a gross surface area of 435,894 km2. In countries where the group is already established, the policy is : - to withdraw from exploration licenses considered as being the least promising in terms of discovery or profitability; - to concentrate on sectors where the existing production means allow for an optimisation of later developments ; - to penetrate more extensive exploration areas with good targets. In the British zone, the additional reserves revealed in the Elgin and Franklin condensate fields have doubled the initial forecast, placing the former among the major fields. All the discoveries made in the British zone have allowed the group to renew productions until now. Elf's production in Piper, Saltire, Chanter is 100,000 b/d which is added to the production of the Claymore and Scapa fields (100,000 b/d). The Flotta terminal processes the crude coming from these fields to which is added the production from the neighbouring fields of Tartan (Texaco) and Ivanhoe-Rob Roy (Amerada Hess), i.e. a total of more than 300,000 b/d. Other than Elgin or the Viking Graben, the future of the Elf group in Great Britain will most certainly come from the West Shetlands and the Irish Sea. In the Norwegian zone, the group has interest in the Frigg, Heimldal, Ekofisk, Valhall, Lille-Frigg, Froy, Oseberg, Hod, Sleipner East an Sleipner West Brage, Troll, Snorre, Statfjord East and Tordis production fields. (authors). 3 tabs., 1 photo

  19. 微型种植体支抗-骨界面压力侧和非压力侧的组织学研究%A histological study on the bone-implant interface of the mini-screw implant anchorage

    Institute of Scientific and Technical Information of China (English)

    冯贻苗; 房兵; 娄新田; 吴勇; 江凌勇

    2011-01-01

    目的 研究在不同愈合时间和负载条件下微型种植体支抗-骨界面压力侧和非压力侧的组织学变化.方法 选用纯种Beagle犬8只,在其上颌根间牙槽骨中植入86颗微型种植体支抗,分别进行即刻负载、愈合2周、愈合4周、愈合12周后加载150 g和300 g牵引力,定期注射荧光标志物,加载2个月后处死动物.标记种植体的压力侧和非压力侧,两侧分别进行种植体颈部骨结合率(BIC)、骨充填率(BSA)和矿物沉积率(MAR)的测量以及HE染色组织形态观察,以BIC和BSA作为骨整合能力的观察指标.结果 即刻负载组和愈合2周负载300克组压力侧的骨整合能力、矿物沉积率和骨改建活跃程度均小于非压力侧,其余各组则相反.不同负载力值组间比较无显著性差异.结论 微型种植体支抗-骨界面颈部即刻负载时压力侧的骨整合和骨改建较非压力侧低,随着愈合时间的延长,压力侧相对增强,非压力侧相对降低,而负载力值对界面的影响较小.%Objective To investigate the histological difference at the bone-implant interface between pressure and non-pressure sides of the mini-screw implant anchorage (MIA) under the condition of different loading force and heeling time. Methods Eighty-six MIAs were inserted in the maxillary alveolar bone between the dental roots in 8 beagles. Healing after 0, 2, 4, 12 weeks, 150 g and 300 g forces were loaded perpendicularly to the implants and fluorochrome was injected. Two months later, all dogs were sacrificed. The slices of MIA on the pressure and non-pressure sides were labeled. Bone implant contact ratio(BIC), bone surface area(BSA) and mineral apposition rate (MAR) were measured and histological observations were carried out. Results BIC, BSA, MAR and bone remodeling on the pressure side were lower than those on the non-pressure side in the immediate loading group and the group healing after 2 weeks with 300 g force, while the reverse result

  20. PREREQUISITES TO UNCOVERING THE REGULARITIES OF THE FATIGUE RESISTANCE OF ANCHORAGE OF CURTAIN WALL SYSTEMS

    Directory of Open Access Journals (Sweden)

    Alisultanov Ramidin Semedovich

    2016-04-01

    Full Text Available Curtain wall systems are subjected to the influence of air flow, which is changing in its direction and speed. Such an influence gives rise to variable forces, which leads to fluctuating stresses in the structures of curtain wall systems. In case of fluctuating stresses the structural element is destroyed at lower loads, than in case of constant stresses. This fracture is called the fatigue. The fatigue fractures lead to drastic consequences because of their sudden emergence. The fracture mode of structural materials depends on the number of loading cycles. The authors state the notions of multicycle and low-cycle fatigue of materials. Some types of fatigue curves are offered. The authors hypothesize on the absence of horizontal areas of Wehler curve in case of plastic materials.

  1. 77 FR 43514 - Anchorage Regulations; Narragansett Bay and Rhode Island Sound, RI

    Science.gov (United States)

    2012-07-25

    ... Rhode Island Sound, RI,'' in the Federal Register (76 FR 15246). We received nine comments on the... Sound, RI AGENCY: Coast Guard, DHS. ACTION: Final rule. SUMMARY: The Coast Guard is removing an obsolete... Island Sound south of Brenton Point, Rhode Island, for use by vessels waiting to enter Narragansett...

  2. Anchorage of collagen-tailed acetylcholinesterase to the extracellular matrix is mediated by heparan sulfate proteoglycans

    OpenAIRE

    1985-01-01

    Heparan sulfate and heparin, two sulfated glycosaminoglycans (GAGs), extracted collagen-tailed acetylcholinesterase (AChE) from the extracellular matrix (ECM) of the electric organ of Discopyge tschudii. The effect of heparan sulfate and heparin was abolished by protamine; other GAGs could not extract the esterase. The solubilization of the asymmetric AChE apparently occurs through the formation of a soluble AChE-GAG complex of 30S. Heparitinase treatment but not chondroitinase ABC treatment ...

  3. Effect of the pilot hole preparation on the anchorage of pedicle screws

    OpenAIRE

    Abrahão, Gustavo Silva; Rosa, Rodrigo César; Okubo, Rodrigo; Shimano, Antônio Carlos

    2012-01-01

    Objective We evaluated the influence of the diameter and the preparation of the pilot hole on the resistance to the pulling out and the strength when inserting pedicle screws with conical internal diameter. Methods Mechanical experiments were performed with pedicle conical screws of 4.2 mm and 5.2 mm diameter. They were inserted in the vertebral pedicles of swine. The hole was manufactured with a drill and probes with different diameters. Results While testing the 4.2 mm screw, the perforatio...

  4. 33 CFR 401.65 - Communication-ports, docks and anchorages.

    Science.gov (United States)

    2010-07-01

    ... giving its destination and the expected time of arrival at the next check point. (c) Every vessel... the expected time of arrival at the next check point. (68 Stat. 93-96, 33 U.S.C. 981-990, as...

  5. Mandibular implant-retained overdenture: a clinical trial of two anchorage systems.

    Science.gov (United States)

    Menicucci, G; Lorenzetti, M; Pera, P; Preti, G

    1998-01-01

    This in-vivo study aimed to investigate the load on the working-side implant and on the edentulous distal mucosa of the nonworking side in a mandibular implant-retained overdenture (MIR-OVD) anchored to 2 implants by either a ball- or a clips-and-bar attachment. Three female patients were provided with duplicate dentures anchored in the 2 ways. Strain on the implant was investigated using a strain-gauged abutment, and load on the mucosa was measured using a suitably placed load cell. Ball attachments appeared to provide greater stability to the MIR-OVD, since load was more evenly distributed onto the distal mucosa of both sides. When the MIR-OVD was bar-anchored, axial load on the working-side abutment increased. PMID:9857597

  6. Mandibular implant-retained overdenture: finite element analysis of two anchorage systems.

    Science.gov (United States)

    Menicucci, G; Lorenzetti, M; Pera, P; Preti, G

    1998-01-01

    Transmission of masticatory load in mandibular implant-retained overdentures was evaluated using a three-dimensional finite element model. The reaction forces on the distal edentulous mucosa and the stress on the perimplant bone were compared in overdentures retained either by two ball attachments or by two clips on a bar connecting two implants. In the finite element model, a 35 N load on the first mandibular molar induced a greater reaction force on the distal edentulous ridge mucosa of the nonworking side when the overdenture was anchored by ball attachments than with the clips/bar attachment. Stress on peri-implant bone was greater with the clips/bar attachment than with the ball attachment. PMID:9638007

  7. H08203: NOS Hydrographic Survey , Anchorage, Alaska, 1955-05-27

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The National Oceanic and Atmospheric Administration (NOAA) has the statutory mandate to collect hydrographic data in support of nautical chart compilation for safe...

  8. Denmark: criminal law as an anchorage point for pro-active anti-terrorism legislation

    DEFF Research Database (Denmark)

    Vestergaard, Jørn

    2012-01-01

    The article focuses on the compatibility of criminal law anti-terrorism legislation in Danish law with basic principles regarding the rule of law and due process. The so-called anti-terror-packages of 2002 and 2006 involve a set of rather uncertain and wide-reaching provisions fundamentally chall......, the challenges regarding rule of law and due process also relate to secondary legislation in fields like law enforcement, criminal procedure, intelligence, public law, treatment of foreigners, etc.......The article focuses on the compatibility of criminal law anti-terrorism legislation in Danish law with basic principles regarding the rule of law and due process. The so-called anti-terror-packages of 2002 and 2006 involve a set of rather uncertain and wide-reaching provisions fundamentally...... challenging the principle of legality and substantially widening of the scope of criminal law. These provisions criminalize various activities more or less remote from actual or attempted terrorist acts and participation in such activities, too. The legislature has even over-implemented vari-ous legal...

  9. Downregulation of Akt1 Inhibits Anchorage-Independent Cell Growth and Induces Apoptosis in Cancer Cells

    Directory of Open Access Journals (Sweden)

    Xuesong Liu

    2001-01-01

    Full Text Available The serine/threonine kinases, Akti/PKBα, Akt2/PKBβ, and Akt3/PKBγ, play a critical role in preventing cancer cells from undergoing apoptosis. However, the function of individual Akt isoforms in the tumorigenicity of cancer cells is still not well defined. In the current study, we used an AM antisense oligonucleotide (AS to specifically downregulate Akti protein in both cancer and normal cells. Our data indicate that AM AS treatment inhibits the ability of MiaPaCa-2, H460, HCT-15, and HT1080 cells to grow in soft agar. The treatment also induces apoptosis in these cancer cells as demonstrated by FRCS analysis and a caspase activity assay. Conversely, Akti AS treatment has little effect on the cell growth and survival of normal human cells including normal human fibroblast (NHF, fibroblast from muscle (FBM, and mammary gland epithelial 184135 cells. In addition, AM AS specifically sensitizes cancer cells to typical chemotherapeutic agents. Thus, Akti is indispensable for maintaining the tumorigenicity of cancer cells. Inhibition of AM may provide a powerful sensitization agent for chemotherapy specifically in cancer cells.

  10. Ancient anchorage systems in India with reference to the Gujarat coast

    Digital Repository Service at National Institute of Oceanography (India)

    Gaur, A.S.; Sundaresh; Tripati, S.

    , Kindar Kheda near Mul Dwarka (Visawada) and Kanjetar and Kaj near Mul Dwarka (Kodinar). All the three Dwarka have ancient temples dated to the 10 th -12 th century AD. Nonetheless, these sites were ancient busy ports and perhaps temples were served... and anchoring points along the west coast of India from the protohistoric period (Ray, 2003, 2). The discovery of a large number of stone structures and anchors at Dwarka suggests that it was a busy port during the historical and the medieval times (Gaur, et...

  11. Ancient technology of jetties and anchorage system along the Saurastra coast, India

    Digital Repository Service at National Institute of Oceanography (India)

    Gaur, A; Sundaresh

    few semicircular structures joined with a hard mortar are partially intact. Structures with 2–3 courses have been noticed at least at 10 locations. The semicircular structures were constructed by using L-shaped blocks with provision for dowels... (lighthouse (Fig. 2.6)) about 4 m. high, constructed with dressed limestone blocks, was noticed. If this structure has served as a lighthouse in the past, it may be the earliest remains of a lighthouse on the Saurashtra coast. Explorations in inter tidal...

  12. Ultimate Bearing Strength of Post-tensioned Local Anchorage Zones in Lightweight Concrete

    OpenAIRE

    Axson, Daniel Peter

    2008-01-01

    Currently, NCHRP Report 356 has published an equation to estimate the ultimate strength of the local zone in normal weight concrete. The local zone is the area of concrete directly ahead of the bearing plate. The equation can be broken into two distinct parts: unconfined bearing strength of concrete enhanced by the A/Ab ratio and the enhancement of strength due to the presence of confining. Research has shown that the strength enhancement of the A/Ab ratio and confining reinfor...

  13. Fatigue of threaded rods in cable anchorages due to Vortex shedding

    NARCIS (Netherlands)

    Maljaars, J.; Snijder, H.H.

    2013-01-01

    The 'Hovenring' is a bicycle roundabout flyover built as a signature bridge with a central steel pylon carrying a circular bridge deck suspended through stay-cables. Shortly after installation of the bridge, the stay-cables turned out to vibrate in the wind due to vortex shedding. These vibrations h

  14. Salmon habitat improvement reconnaissance, Prince William Sound, Cordova and Anchorage districts, September 1985

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report is on the salmon habitat improvement reconnaissance in the Prince William sound, Alaska. The purpose of the trip was to discover new habitat improvement...

  15. Group Distal Movement of Teeth using Micro-Screw–Implant Anchorage-A Case Report

    Science.gov (United States)

    2014-01-01

    This case report describes a case of orthodontic tooth movement of a 29-year-old female patient utilizing maxillary posterior edentulous area. Micro-implants were placed at buccal edentulous spaces and inter-radicular space for retraction of entire maxillary dentition. An overjet reduction of 8mm and good posterior occlusion were achieved. PMID:24995260

  16. Group Distal Movement of Teeth using Micro-Screw-Implant Anchorage-A Case Report.

    Science.gov (United States)

    Kalarickal, Biju

    2014-05-01

    This case report describes a case of orthodontic tooth movement of a 29-year-old female patient utilizing maxillary posterior edentulous area. Micro-implants were placed at buccal edentulous spaces and inter-radicular space for retraction of entire maxillary dentition. An overjet reduction of 8mm and good posterior occlusion were achieved. PMID:24995260

  17. INFLUENCE OF PIT WALL ANCHORAGE ONTO ADDITIONAL DEFORMATIONS OF EXISTING BUILDINGS

    Directory of Open Access Journals (Sweden)

    Kubetskiy Valeriy Leonidovich

    2012-07-01

    Assessment of additional projected deformations of buildings located in close proximity to pits is exemplified by the specific structure of the pit support system that has active PIT [1] anchors. The authors also consider the influence produced by the structure of anchors onto the two buildings located within the area of influence of the excavation works and protected by the anchors installed underneath the foundations of the two adjacent buildings.

  18. 33 CFR 166.200 - Shipping safety fairways and anchorage areas, Gulf of Mexico.

    Science.gov (United States)

    2010-07-01

    ... Navigation or danger markings must be installed as required by 33 CFR Subchapter C. (c) Special Conditions...: For Federal Register citations affecting § 166.200, see the List of CFR Sections Affected, which... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Shipping safety fairways...

  19. 77 FR 19155 - Federal Motor Vehicle Safety Standards; Seat Belt Assembly Anchorages; Incorporation by Reference

    Science.gov (United States)

    2012-03-30

    ... NPRM that, among other matters, proposed to require passenger seat belts on motorcoaches (75 FR 50958... published on April 11, 2000 (65 FR 19477-78). FOR FURTHER INFORMATION CONTACT: For non-legal issues: Ms... tested with the body block placed against the seat back, and that NHTSA's placement of the pelvic...

  20. H08213: NOS Hydrographic Survey , Anchorage, Alaska, 1955-06-30

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The National Oceanic and Atmospheric Administration (NOAA) has the statutory mandate to collect hydrographic data in support of nautical chart compilation for safe...

  1. Anchorage of titanium implants with different surface characteristics: an experimental study in rabbits

    DEFF Research Database (Denmark)

    Gotfredsen, K; Berglundh, T; Lindhe, J

    2000-01-01

    ) TiO2-blasted with particles of grain size 10 to 53 microns; (3) TiO2-blasted, grain size 63 to 90 microns; (4) TiO2-blasted, grain size 90 to 125 microns; (5) titanium plasma-sprayed (TPS). The surface topography was determined by the use of an optical instrument. Twelve rabbits, divided into two...... and Sy values, whereas the highest scores were recorded for the TPS implants. The corresponding Sa and Sy values for the TiO2-blasted implants were higher when a larger size of grain particles had been used for blasting. At all four observation intervals, the TPS implants had the highest and the...... turned implants the lowest RMT scores. The differences between the various TiO2-blasted implants were, in general, small, but the screws with the largest Sa value had higher RMT scores at 6, 9, and 12 weeks than implants with lower Sa values. The histologic analysis of the sections representing 6, 9, and...

  2. Being physically active : a bodily anchorage on the journey for recovery in mental ill-health

    OpenAIRE

    Lassenius, Oona

    2014-01-01

    Suffering from mental ill-health does not merely involve mental distress; it also often comprises deteriorated physical health. The physical consequences can be of a severe nature and may lead to premature death. Since physical inactivity has been identified as a critical health risk factor, there is an imperative need to support physical activity in persons with mental ill-health. The benefits of being physically active for persons with mental ill-health are many, but there are also consider...

  3. Group Distal Movement of Teeth using Micro-Screw–Implant Anchorage-A Case Report

    OpenAIRE

    Kalarickal, Biju

    2014-01-01

    This case report describes a case of orthodontic tooth movement of a 29-year-old female patient utilizing maxillary posterior edentulous area. Micro-implants were placed at buccal edentulous spaces and inter-radicular space for retraction of entire maxillary dentition. An overjet reduction of 8mm and good posterior occlusion were achieved.

  4. F00267: NOS Hydrographic Survey , Chesapeake Bay Hurricane Anchorages, Virginia, 1984-06-21

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The National Oceanic and Atmospheric Administration (NOAA) has the statutory mandate to collect hydrographic data in support of nautical chart compilation for safe...

  5. A role for collagen XXIII in cancer cell adhesion, anchorage-independence, and metastasis

    OpenAIRE

    Spivey, Kristin A.; Chung, Ivy; Banyard, Jacqueline; Adini, Irit; Feldman, Henry A.; Bruce R Zetter

    2011-01-01

    Collagen XXIII is a transmembrane collagen previously shown to be upregulated in metastatic prostate cancer that has been used as a tissue and fluid biomarker for non-small cell lung cancer and prostate cancer. To determine whether collagen XXIII facilitates cancer cell metastasis in vivo and to establish a function for collagen XXIII in cancer progression, collagen XXIII knockdown cells were examined for alterations in in vivo metastasis as well as in vitro cell adhesion. In experimental and...

  6. Neural maintenance roles for the matrix receptor dystroglycan and the nuclear anchorage complex in Caenorhabditis elegans

    NARCIS (Netherlands)

    Johnson, R.P.; Kramer, J.M.

    2012-01-01

    Recent studies in Caenorhabditis elegans have revealed specific neural maintenance mechanisms that protect soma and neurites against mispositioning due to displacement stresses, such as muscle contraction. We report that C. elegans dystroglycan (DG) DGN-1 functions to maintain the position of lumbar

  7. 76 FR 15246 - Anchorage Regulations; Narragansett Bay and Rhode Island Sound, RI

    Science.gov (United States)

    2011-03-21

    ... regarding our public dockets in the January 17, 2008 issue of the Federal Register (73 FR 3316). Public... coordinates referenced use datum: NAD 83. Dated: March 3, 2011. Daniel A. Neptun, Rear Admiral, U.S....

  8. 77 FR 5743 - Special Anchorage Areas; Port of New York, NY

    Science.gov (United States)

    2012-02-06

    ..., 2008, issue of the Federal Register (73 FR 3316). Public Meeting We do not now plan to hold a public.... Neptun, Rear Admiral, U.S. Coast Guard Commander, First Coast Guard District. BILLING CODE 9110-04-P...

  9. NUMERICAL ANALYSIS OF ANCHORAGE PERFORMANCE ON SAND CONSOLIDATED ANCHORAGE PRESTRESSED BOLT BY PARTICLE FLOW CODE%砂固结预应力锚杆锚固性能的颗粒流数值分析

    Institute of Scientific and Technical Information of China (English)

    张思峰; 周健; 李艳梅

    2007-01-01

    基于颗粒流理论,建立分析砂固结预应力锚杆锚固性能的颗粒流数值分析模型.通过数值模型试验,对砂固结预应力锚杆的荷载-位移特性以及砂颗粒在载荷作用下的应力、位移及孔隙率变化规律等细观特性进行分析.分析结果表明:加载初期挡板位移增长较快;而随着荷载逐级增大,表现出位移增量的逐级收敛性;随挡板移动,砂颗粒内部孔隙率及其相互之间的接触力从距离挡板由近及远分别经历孔隙率减小、颗粒接触力增大的过程,并最终分别趋于稳定.通过与室内模型试验结果相对比,验证数值模拟的正确性,并通过对挡板埋置深度、砂体初始孔隙率、挡板宽度等因素的分析,探讨影响砂固结预应力锚杆锚固性能的一些因素.

  10. Accelerated Sorption Diffusion for Cu(II) Retention by Anchorage of Nano-zirconium Dioxide onto Highly charged Polystyrene Material

    Science.gov (United States)

    Zhang, Qingrui; Du, Qing; Jiao, Tifeng; Teng, Jie; Sun, Qina; Peng, Qiuming; Chen, Xinqing; Gao, Faming

    2015-01-01

    The development of nanocomposite with strong adsorption ability exhibits great potential applications for environmental remediation. However, the pore blocking in preparation frequently constrains sorption diffusion, resulting in low utilization efficiency. Here we synthesized a new nano-ZrO2/Polystyrene (NZO-PS) material tailored with a specific fixed SO3-Na group to enhance Cu(II) removal. The NZO-PS exhibits efficient Cu(II) sequestration in a wide pH range (3.0–6.5) and preferential sorption performances. The efficient kinetic behavior and column applicability suggest the blocked pore channel is not a matter when presence of negatively charged moiety, which accelerates Cu(II) sorption diffusion and enrichment toward target active site. Moreover, the exhausted NZO-PS can be readily regenerated through HCl-NaCl binary solution. The preparation route can be extended to synthesize other functional composited materials. Simultaneously, the characteristics of simplicity, high-yield and regeneration provide some promising industrial merits. PMID:26184921

  11. Alpha9beta1 integrin in melanoma cells can signal different adhesion states for migration and anchorage

    DEFF Research Database (Denmark)

    Lydolph, Magnus C; Morgan-Fisher, Marie; Høye, Anette M;

    2009-01-01

    Cell surface integrins are the primary receptors for cell migration on extracellular matrix, and exist in several activation states regulated in part by ectodomain conformation. The alpha9 integrin subunit, which pairs only with beta1, has specific roles in the immune system and may regulate cell......beta1 integrin- and Rho kinase-dependent focal adhesion and stress fibre formation, suggesting that the activation status of alpha9beta1 integrin was altered. The effect of manganese ions in promoting focal adhesion formation was reproduced by beta1 integrin activating antibody. The alpha9beta1...

  12. KSHV MicroRNAs Repress Tropomyosin 1 and Increase Anchorage-Independent Growth and Endothelial Tube Formation

    OpenAIRE

    Kieffer-Kwon, Philippe; Happel, Christine; Uldrick, Thomas S.; Ramalingam, Dhivya; Ziegelbauer, Joseph M.

    2015-01-01

    Kaposi’s sarcoma (KS) is characterized by highly vascularized spindle-cell tumors induced after infection of endothelial cells by Kaposi’s sarcoma-associated herpesvirus (KSHV). In KS tumors, KSHV expresses only a few latent proteins together with 12 pre-microRNAs. Previous microarray and proteomic studies predicted that multiple splice variants of the tumor suppressor protein tropomyosin 1 (TPM1) were targets of KSHV microRNAs. Here we show that at least two microRNAs of KSHV, miR-K2 and miR...

  13. Orthogonal Click Conjugation to the Liposomal Surface Reveals the Stability of the Lipid Anchorage as Crucial for Targeting.

    Science.gov (United States)

    Fritz, Thomas; Voigt, Matthias; Worm, Matthias; Negwer, Inka; Müller, Sophie S; Kettenbach, Kathrin; Ross, Tobias L; Roesch, Frank; Koynov, Kaloian; Frey, Holger; Helm, Mark

    2016-08-01

    Synthetic access to multiple surface decorations are a bottleneck in the development of liposomes for receptor mediated targeting. This opens a complex multiparameter space, exploration of which is severely limited in terms of sample numbers and turnaround times. Here, we unlock this technological barrier by a combination of a milligram-scale liposome formulation using dual centrifugation and orthogonal click chemistry on the liposomal surface. Application of these techniques to conceptually new amphiphilic compounds, which feature norbornene and alkyne groups at the apex of sterically stabilizing, hyperbranched polyglycerol moieties, revealed a particular influence of the membrane anchor of functional amphiphiles. Folic acid residues clicked to cholesterol-based amphiphiles were inefficient in folate-mediated cell targeting, while dialkyl-anchored amphiphiles remained stable in the liposomal membrane and imparted efficient targeting properties. These findings are of specific importance considering the popularity of cholesterol as a lipophilic anchor. PMID:27403892

  14. The LKB1 tumor suppressor differentially affects anchorage independent growth of HPV positive cervical cancer cell lines

    International Nuclear Information System (INIS)

    Infection with high-risk human papillomaviruses is causally linked to cervical carcinogenesis. However, most lesions caused by high-risk HPV infections do not progress to cancer. Host cell mutations contribute to malignant progression but the molecular nature of such mutations is unknown. Based on a previous study that reported an association between liver kinase B1 (LKB1) tumor suppressor loss and poor outcome in cervical cancer, we sought to determine the molecular basis for this observation. LKB1-negative cervical and lung cancer cells were reconstituted with wild type or kinase defective LKB1 mutants and we examined the importance of LKB1 catalytic activity in known LKB1-regulated processes including inhibition of cell proliferation and elevated resistance to energy stress. Our studies revealed marked differences in the biological activities of two kinase defective LKB1 mutants in the various cell lines. Thus, our results suggest that LKB1 may be a cell-type specific tumor suppressor. - Highlights: • LKB1 is a tumor suppressor that is linked to Peutz-Jeghers syndrome. • Peutz-Jeghers syndrome patients have a high incidence of cervical cancer. • Cervical cancer is caused by HPV infections. • This study investigates LKB1 tumor suppressor activity in cervical cancer

  15. Three-Dimensional Finite Element Analysis of Anterior Single Implant-Supported Prostheses with Different Bone Anchorages

    OpenAIRE

    Fellippo Ramos Verri; Joel Ferreira Santiago Júnior; Daniel Augusto de Faria Almeida; Ana Caroline Gonçales Verri; Victor Eduardo de Souza Batista; Cleidiel Aparecido Araujo Lemos; Pedro Yoshito Noritomi; Eduardo Piza Pellizzer

    2015-01-01

    The aim of this study was to evaluate the stress distribution of monocortical and bicortical implant placement of external hexagon connection in the anterior region of the maxilla by 3D finite element analysis (FEA). 3D models were simulated to represent a bone block of anterior region of the maxilla containing an implant (4.0 × 10.0 mm) and an implant-supported cemented metalloceramic crown of the central incisor. Different techniques were tested (monocortical, bicortical, and bicortical ass...

  16. CD13 Regulates Anchorage and Differentiation of the Skeletal Muscle Satellite Stem Cell Population in Ischemic Injury

    OpenAIRE

    Rahman, M. Mamunur; Ghosh, Mallika; Subramani, Jaganathan; Fong, Guo-Hua; Carlson, Morgan E.; Shapiro, Linda H.

    2014-01-01

    CD13 is a multifunctional cell surface molecule that regulates inflammatory and angiogenic mechanisms in vitro, but its contribution to these processes in vivo or potential roles in stem cell biology remains unexplored. We investigated the impact of loss of CD13 on a model of ischemic skeletal muscle injury that involves angiogenesis, inflammation and stem cell mobilization. Consistent with its role as an inflammatory adhesion molecule, lack of CD13 altered myeloid trafficking in the injured ...

  17. Measurement of strain distribution in cortical bone around miniscrew implants used for orthodontic anchorage using digital speckle pattern interferometry

    Science.gov (United States)

    Kumar, Manoj; Agarwal, Rupali; Bhutani, Ravi; Shakher, Chandra

    2016-05-01

    An application of digital speckle pattern interferometry (DSPI) for the measurement of deformations and strain-field distributions developed in cortical bone around orthodontic miniscrew implants inserted into the human maxilla is presented. The purpose of this study is to measure and compare the strain distribution in cortical bone/miniscrew interface of human maxilla around miniscrew implants of different diameters, different implant lengths, and implants of different commercially available companies. The technique is also used to measure tilt/rotation of canine caused due to the application of retraction springs. The proposed technique has high sensitivity and enables the observation of deformation/strain distribution. In DSPI, two specklegrams are recorded corresponding to pre- and postloading of the retraction spring. The DSPI fringe pattern is observed by subtracting these two specklegrams. Optical phase was extracted using Riesz transform and the monogenic signal from a single DSPI fringe pattern. The obtained phase is used to calculate the parameters of interest such as displacement/deformation and strain/stress. The experiment was conducted on a dry human skull fulfilling the criteria of intact dental arches and all teeth present. Eight different miniscrew implants were loaded with an insertion angulation of 45 deg in the inter-radicular region of the maxillary second premolar and molar region. The loading of miniscrew implants was done with force level (150 gf) by nickel-titanium closed-coil springs (9 mm). The obtained results from DSPI reveal that implant diameter and implant length affect the displacement and strain distribution in cortical bone layer surrounding the miniscrew implant.

  18. Down-regulation of Survivin by Antisense Oligonucleotides Increases Apoptosis, Inhibits Cytokinesis and Anchorage-Independent Growth

    Directory of Open Access Journals (Sweden)

    Jun Chen

    2000-05-01

    Full Text Available Survivin, a member of the inhibitor of apoptosis protein (IAP family, is detected in most common human cancers but not in adjacent normal cells. Previous studies suggest that survivin associates with the mitotic spindle and directly inhibits caspase activity. To further investigate the function of survivin, we used a survivin antisense (AS oligonucleotide to downregulate survivin expression in normal and cancer cells. We found that inhibition of survivin expression increased apoptosis and polyploidy while decreasing colony formation in soft agar. Immunohistochemistry showed that cells without survivin can initiate the cleavage furrow and contractile ring, but cannot complete cytokinesis, thus resulting in multinucleated cells. These findings indicate that survivin plays important roles in a late stage of cytokinesis, as well as in apoptosis.

  19. Amino-functionalized monolayers covalently grafted to silica-based substrates as a robust primer anchorage in aqueous media

    Science.gov (United States)

    Giraud, Lucie; Nadarajah, Rakini; Matar, Yasmine; Bazin, Gwénaëlle; Sun, Jing; Zhu, X. X.; Giasson, Suzanne

    2016-05-01

    Controlling surface coverage and stability of supported aminoalkylsilane monolayers on silica-based substrates still remains a challenge for the development of biosensors and nanomaterials. We have developed protocols using simple surface chemistry and self-assembly from solution without stringent deposition conditions to covalently attach monolayers of 11-aminoundecyltriethoxysilane (AUTES) onto mica and silica substrates. The resulting self-assembled monolayers (SAMs) exhibited excellent hydrolytic stability. The long alkyl chain together with the large grafting density and homogeneity enhanced the monolayer stability by preventing the Sisilanesbnd Osbnd Sisurface bonds from hydrolysis over a wide range of pH values (2-10) for long time periods (up to 8 days). The control over the surface density of amino groups was achieved and the reactivity of the amino SAMs was confirmed by covalently attaching carboxyl-functionalized nanoparticles on the SAMs. The immobilized nanoparticles exhibited the same hydrolytic stability as that of the SAMs. The AUTES SAMs prepared in this study exhibited the best hydrolytic stability of similar systems reported so far.

  20. 76 FR 20287 - Superfund Site, New Bedford Harbor, New Bedford, MA: Anchorage Ground and Regulated Navigation Area

    Science.gov (United States)

    2011-04-12

    ..., 2008, issue of the Federal Register (73 FR 3316). Public Meeting We do not now plan to hold a public... establish a regulated navigation area (RNA) prohibiting activities that disturb the ] seabed around the site... the docket, call Renee V. Wright, Program Manager, Docket Operations, telephone...

  1. The LKB1 tumor suppressor differentially affects anchorage independent growth of HPV positive cervical cancer cell lines

    Energy Technology Data Exchange (ETDEWEB)

    Mack, Hildegard I.D.; Munger, Karl, E-mail: kmunger@rics.bwh.harvard.edu

    2013-11-15

    Infection with high-risk human papillomaviruses is causally linked to cervical carcinogenesis. However, most lesions caused by high-risk HPV infections do not progress to cancer. Host cell mutations contribute to malignant progression but the molecular nature of such mutations is unknown. Based on a previous study that reported an association between liver kinase B1 (LKB1) tumor suppressor loss and poor outcome in cervical cancer, we sought to determine the molecular basis for this observation. LKB1-negative cervical and lung cancer cells were reconstituted with wild type or kinase defective LKB1 mutants and we examined the importance of LKB1 catalytic activity in known LKB1-regulated processes including inhibition of cell proliferation and elevated resistance to energy stress. Our studies revealed marked differences in the biological activities of two kinase defective LKB1 mutants in the various cell lines. Thus, our results suggest that LKB1 may be a cell-type specific tumor suppressor. - Highlights: • LKB1 is a tumor suppressor that is linked to Peutz-Jeghers syndrome. • Peutz-Jeghers syndrome patients have a high incidence of cervical cancer. • Cervical cancer is caused by HPV infections. • This study investigates LKB1 tumor suppressor activity in cervical cancer.

  2. Fluxes of water through aquaporin 9 weaken membrane-cytoskeleton anchorage and promote formation of membrane protrusions.

    Directory of Open Access Journals (Sweden)

    Thommie Karlsson

    Full Text Available All modes of cell migration require rapid rearrangements of cell shape, allowing the cell to navigate within narrow spaces in an extracellular matrix. Thus, a highly flexible membrane and a dynamic cytoskeleton are crucial for rapid cell migration. Cytoskeleton dynamics and tension also play instrumental roles in the formation of different specialized cell membrane protrusions, viz. lamellipodia, filopodia, and membrane blebs. The flux of water through membrane-anchored water channels, known as aquaporins (AQPs has recently been implicated in the regulation of cell motility, and here we provide novel evidence for the role of AQP9 in the development of various forms of membrane protrusion. Using multiple imaging techniques and cellular models we show that: (i AQP9 induced and accumulated in filopodia, (ii AQP9-associated filopodial extensions preceded actin polymerization, which was in turn crucial for their stability and dynamics, and (iii minute, local reductions in osmolarity immediately initiated small dynamic bleb-like protrusions, the size of which correlated with the reduction in osmotic pressure. Based on this, we present a model for AQP9-induced membrane protrusion, where the interplay of water fluxes through AQP9 and actin dynamics regulate the cellular protrusive and motile activity of cells.

  3. 78 FR 11745 - Anchorages; Lower Mississippi River, Above Head of Passes, Convent, LA and Point Pleasant, LA

    Science.gov (United States)

    2013-02-20

    ... of the river, which is necessary to help accommodate increased vessel volume and improve navigational... Acronyms DHS Department of Homeland Security FR Federal Register NPRM Notice of Proposed Rulemaking A... Proposed Rule Making (NPRM) in the Federal Register (77 FR 66942). There were 3 comments received....

  4. Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions in vivo.

    Directory of Open Access Journals (Sweden)

    Martin F Dietrich

    Full Text Available BACKGROUND: The low-density lipoprotein (LDL receptor gene family is a highly conserved group of membrane receptors with diverse functions in developmental processes, lipoprotein trafficking, and cell signaling. The low-density lipoprotein (LDL receptor-related protein 1b (LRP1B was reported to be deleted in several types of human malignancies, including non-small cell lung cancer. Our group has previously reported that a distal extracellular truncation of murine Lrp1b that is predicted to secrete the entire intact extracellular domain (ECD is fully viable with no apparent phenotype. METHODS AND PRINCIPAL FINDINGS: Here, we have used a gene targeting approach to create two mouse lines carrying internally rearranged exons of Lrp1b that are predicted to truncate the protein closer to the N-terminus and to prevent normal trafficking through the secretary pathway. Both mutations result in early embryonic lethality, but, as expected from the restricted expression pattern of LRP1b in vivo, loss of Lrp1b does not cause cellular lethality as homozygous Lrp1b-deficient blastocysts can be propagated normally in culture. This is similar to findings for another LDL receptor family member, Lrp4. We provide in vitro evidence that Lrp4 undergoes regulated intramembraneous processing through metalloproteases and gamma-secretase cleavage. We further demonstrate negative regulation of the Wnt signaling pathway by the soluble extracellular domain. CONCLUSIONS AND SIGNIFICANCE: Our results underline a crucial role for Lrp1b in development. The expression in mice of truncated alleles of Lrp1b and Lrp4 with deletions of the transmembrane and intracellular domains leads to release of the extracellular domain into the extracellular space, which is sufficient to confer viability. In contrast, null mutations are embryonically (Lrp1b or perinatally (Lrp4 lethal. These findings suggest that the extracellular domains of both proteins may function as a scavenger for signaling ligands or signal modulators in the extracellular space, thereby preserving signaling thresholds that are critical for embryonic development, as well as for the clear, but poorly understood role of LRP1b in cancer.

  5. The Zonules Selectively Alter the Shape of the Lens During Accommodation Based on the Location of Their Anchorage Points

    Science.gov (United States)

    Nankivil, Derek; Maceo Heilman, Bianca; Durkee, Heather; Manns, Fabrice; Ehrmann, Klaus; Kelly, Shawn; Arrieta-Quintero, Esdras; Parel, Jean-Marie

    2015-01-01

    Purpose. To determine the role of anterior and posterior zonular tension on the optomechanical lens response during accommodation simulation. Methods. Ten eyes from nine hamadryas baboons (4.9 ± 0.7 years) and 20 eyes from 18 cynomolgus monkeys (5.4 ± 0.3 years) were dissected, leaving the lens, zonules, ciliary body, hyaloid membrane, anterior vitreous, and a segmented scleral rim intact. The lens preparation was mounted in a lens stretcher, and the outer scleral shell was displaced radially in a stepwise fashion. The load, lens, and ciliary body diameters, lens power, lens thickness, and the anterior and posterior radius of curvature were measured during stretching. The zonular fibers attached to either the posterior or anterior lens surface were then carefully transected and the experiment was repeated. Zonular transection was confirmed in four eyes via laser scanning confocal microscopy after immunostaining. The effect of zonular transection on the tissue response to stretching was quantified. Results. Without anterior zonules, 48% and 97% of the changes in anterior and posterior radii are retained. Without posterior zonules, 81% and 67% of the changes in anterior and posterior radii are retained. The changes in lens shape were reduced after transecting either the anterior or posterior zonules; however, both surfaces still changed shape. Conclusions. While either the anterior or posterior zonules alone are capable of changing the shape of both lens surfaces, the anterior zonules have a greater effect on the anterior lens surface, and the posterior zonules have a greater effect on the posterior lens surface. PMID:25698707

  6. Anchorage of TiO2-blasted, HA-coated, and machined implants: an experimental study with rabbits

    DEFF Research Database (Denmark)

    Gotfredsen, K; Wennerberg, A; Johansson, C;

    1995-01-01

    rabbit had a machined, a TiO2-blasted, and a TiO2-blasted, HA-coated implant placed in each tibia. After a healing period of 3 and 12 weeks, respectively, the implants placed in the right tibia were used for removal torque test, and the implants placed in the left tibia were used for histomorphometrical...

  7. 75 FR 38465 - Taking and Importing Marine Mammals; Taking Marine Mammals Incidental to the Port of Anchorage...

    Science.gov (United States)

    2010-07-02

    ... driving were issued on July 15, 2009 (74 FR 35136), and remain in effect until July 14, 2014. These... (APU) to implement a NMFS-approved scientific monitoring plan. The scientific marine mammal monitoring.... The APU observers conducted scientific monitoring from the Cairn Point Station on Elmendorf Air...

  8. 76 FR 39386 - Taking and Importing Marine Mammals; Taking Marine Mammals Incidental to the Port of Anchorage...

    Science.gov (United States)

    2011-07-06

    ... vitulina), by Level B harassment, incidental to in-water pile driving were issued on July 15, 2009 (74 FR... monitoring team from the Alaska Pacific University (APU) to implement a NMFS-approved scientific monitoring... (ICRC, 2011). A summary of that report follows. The APU observers conducted scientific monitoring...

  9. 76 FR 35742 - Superfund Site, New Bedford Harbor, New Bedford, MA: Anchorage Ground and Regulated Navigation Area

    Science.gov (United States)

    2011-06-20

    ... Register (76 FR 20287). We received no comments on the proposed rule. A public meeting was not requested....S. Coast Guard. Dated: June 6, 2011. D.A. Neptun, Rear Admiral, U.S. Coast Guard, Commander,...

  10. 75 FR 54092 - North Pacific Fishery Management Council; Public Meeting

    Science.gov (United States)

    2010-09-03

    ... Management Council's (Council) Scallop Plan Team will meet September 28th, 2010 at the Anchorage Hilton Hotel... be held at the Anchorage Hilton Hotel, 500 West 3rd Avenue, Anchorage, AK 99501. Council...

  11. "Landslide at sunuapa 401 (hydrocarbon exploration well). Risk reduction by mitigation measures: drainage, piles barrier and anchorages system, shotcrete and reforestation, Chiapas, México".

    Science.gov (United States)

    Cuanalo, Oscar; Polanco, Gabriel; Rivera, Julio

    2013-04-01

    We report the case of a landslide of hydrocarbon exploration well "Sunuapa 401" located in Chiapas, Mexico. First were identified the determinants and triggers factors (morphology, geology, rain, seismic and volcanic activity, human activity, etc); second we assessed the threat, vulnerability and risk from geotechnical stability analysis (safety factor and critical failure surface); third, by using the methodology of valuation factors, stabilization processes were selected and designed, and finally they were built by Petróleos Mexicanos, in order to avoid a disaster (environmental, ecological and social). These construction processes included drainage elements, flattening and benching of slopes, piles barrier and anchors, shotcrete and reforestation.

  12. Influência do preparo do orifício piloto na ancoragem dos parafusos pediculares Effect of the pilot hole preparation on the anchorage of pedicle screws

    OpenAIRE

    Gustavo Silva Abrahão; Rodrigo César Rosa; Rodrigo Okubo; Antônio Carlos Shimano

    2012-01-01

    OBJETIVO: Avaliamos a influência do diâmetro e do modo de preparação do orifício piloto na resistência ao arrancamento e no torque de inserção dos parafusos pediculares com diâmetro interno cônico. MÉTODOS: Ensaios mecânicos foram realizados com parafusos pediculares com alma cônica e diâmetro de 4,2mm e 5,2mm inseridos nos pedículos vertebrais lombares de suínos. O orifício piloto foi confeccionado com de broca e sondas (pontiaguda e cortante) com diferentes diâmetros. RESULTADOS: Testando o...

  13. Influência do preparo do orifício piloto na ancoragem dos parafusos pediculares Effect of the pilot hole preparation on the anchorage of pedicle screws

    Directory of Open Access Journals (Sweden)

    Gustavo Silva Abrahão

    2012-01-01

    Full Text Available OBJETIVO: Avaliamos a influência do diâmetro e do modo de preparação do orifício piloto na resistência ao arrancamento e no torque de inserção dos parafusos pediculares com diâmetro interno cônico. MÉTODOS: Ensaios mecânicos foram realizados com parafusos pediculares com alma cônica e diâmetro de 4,2mm e 5,2mm inseridos nos pedículos vertebrais lombares de suínos. O orifício piloto foi confeccionado com de broca e sondas (pontiaguda e cortante com diferentes diâmetros. RESULTADOS: Testando o parafuso de 4,2mm a perfuração com orifício igual ou inferior ao menor diâmetro interno do parafuso, aumentou o torque e a resistência ao arrancamento. Perfurações com diferentes instrumentos apresentaram comportamento semelhante. Perfurações com sondas permitiram que orifícios confeccionados com dimensões superiores ao menor diâmetro interno do parafuso apresentassem resistência semelhante a das perfurações com dimensões iguais ao menor diâmetro interno do implante, realizadas com sondas e brocas. CONCLUSÕES: Nos de 4,2 mm o diâmetro e o modo de preparação do orifício influenciam o torque e a resistência, nos de 5,2 mm apenas o torque de inserção. Não há correlação entre força de arrancamento e torque de inserção. Nível de evidência II, Estudos terapêuticos - Investigação dos Resultados do Tratamento.OBJECTIVE: We evaluated the influence of the diameter and the preparation of the pilot hole on the resistance to the pulling out and the strength when inserting pedicle screws with conical internal diameter. METHODS: Mechanical experiments were performed with pedicle conical screws of 4.2 mm and 5.2 mm diameter. They were inserted in the vertebral pedicles of swine. The hole was manufactured with a drill and probes with different diameters. RESULTS: While testing the 4.2 mm screw, the perforation of holes with measure equal or inferior to the lesser internal diameter of the screw increased the torque and the resistance to pulling out. Perforations with different instruments have presented similar results. Perforations with probes allowed the holes manufactured with dimensions superior to the lesser internal diameter of the screw to show similar resistance to that of the perforations with dimensions equal to the lesser internal diameter of the implant, made with probes and drills. CONCLUSIONS: For 4.2 mm screws, the diameter and the preparation of the hole influence the torque and the resistance. For 5.2 mm screws, there is only influence on the insertion torque. There is no correlation between pulling out strength and insertion torque. Level of Evidence II, Therapeutic Studies - Investigating the Results of Treatment.

  14. A role for Mfb1p in region-specific anchorage of high-functioning mitochondria and lifespan in Saccharomyces cerevisiae

    OpenAIRE

    Pernice, Wolfgang M.; Vevea, Jason D.; Pon, Liza A.

    2016-01-01

    Previous studies indicate that replicative lifespan in daughter cells of Sacchraromyces cerevisiae depends on the preferential inheritance of young, high-functioning mitochondria. We report here that mitochondria are functionally segregated even within single mother cells in S. cerevisiae. A high-functioning population of mitochondria accumulates at the tip of the mother cell distal to the bud. We find that the mitochondrial F-box protein (Mfb1p) localizes to mitochondria in the mother tip an...

  15. Brefeldin A Reduces Anchorage-Independent Survival, Cancer Stem Cell Potential and Migration of MDA-MB-231 Human Breast Cancer Cells

    Directory of Open Access Journals (Sweden)

    Chao-Neng Tseng

    2014-10-01

    Full Text Available Cancer stem cells (CSCs are a subset of cancer cells in tumors or established cancer cell lines that can initiate and sustain the growth of tumors in vivo. Cancer stem cells can be enriched in serum-free, suspended cultures that allow the formation of tumorspheres over several days to weeks. Brefeldin A (BFA is a mycotoxin that induces endoplasmic reticulum (ER stress in eukaryotic cells. We found that BFA, at sub-microgram per milliliter concentrations, preferentially induced cell death in MDA-MB-231 suspension cultures (EC50: 0.016 µg/mL compared to adhesion cultures. BFA also effectively inhibited clonogenic activity and the migration and matrix metalloproteinases-9 (MMP-9 activity of MDA-MB-231 cells. Western blotting analysis indicated that the effects of BFA may be mediated by the down-regulation of breast CSC marker CD44 and anti-apoptotic proteins Bcl-2 and Mcl-1, as well as the reversal of epithelial-mesenchymal transition. Furthermore, BFA also displayed selective cytotoxicity toward suspended MDA-MB-468 cells, and suppressed tumorsphere formation in T47D and MDA-MB-453 cells, suggesting that BFA may be effective against breast cancer cells of various phenotypes.

  16. Cigarette side-stream smoke lung and bladder carcinogenesis: inducing mutagenic acrolein-DNA adducts, inhibiting DNA repair and enhancing anchorage-independent-growth cell transformation.

    Science.gov (United States)

    Lee, Hyun-Wook; Wang, Hsiang-Tsui; Weng, Mao-wen; Chin, Chiu; Huang, William; Lepor, Herbert; Wu, Xue-Ru; Rom, William N; Chen, Lung-Chi; Tang, Moon-shong

    2015-10-20

    Second-hand smoke (SHS) is associated with 20-30% of cigarette-smoke related diseases, including cancer. Majority of SHS (>80%) originates from side-stream smoke (SSS). Compared to mainstream smoke, SSS contains more tumorigenic polycyclic aromatic hydrocarbons and acrolein (Acr). We assessed SSS-induced benzo(a)pyrene diol epoxide (BPDE)- and cyclic propano-deoxyguanosine (PdG) adducts in bronchoalveolar lavage (BAL), lung, heart, liver, and bladder-mucosa from mice exposed to SSS for 16 weeks. In SSS exposed mice, Acr-dG adducts were the major type of PdG adducts formed in BAL (p < 0.001), lung (p < 0.05), and bladder mucosa (p < 0.001), with no significant accumulation of Acr-dG adducts in heart or liver. SSS exposure did not enhance BPDE-DNA adduct formation in any of these tissues. SSS exposure reduced nucleotide excision repair (p < 0.01) and base excision repair (p < 0.001) in lung tissue. The levels of DNA repair proteins, XPC and hOGG1, in lung tissues of exposed mice were significantly (p < 0.001 and p < 0.05) lower than the levels in lung tissues of control mice. We found that Acr can transform human bronchial epithelial and urothelial cells in vitro. We propose that induction of mutagenic Acr-DNA adducts, inhibition of DNA repair, and induction of cell transformation are three mechanisms by which SHS induces lung and bladder cancers. PMID:26431382

  17. Suppression of autophagy by CUB domain-containing protein 1 signaling is essential for anchorage-independent survival of lung cancer cells.

    Science.gov (United States)

    Uekita, Takamasa; Fujii, Satoko; Miyazawa, Yuri; Hashiguchi, Akinori; Abe, Hitosi; Sakamoto, Michiie; Sakai, Ryuichi

    2013-07-01

    CUB (C1r/C1s, urchin embryonic growth factor, BMP1) domain-containing protein 1 (CDCP1) has been implicated in promoting metastasis of cancer cells through several mechanisms, including the inhibition of anoikis, which is cell death triggered by the loss of extracellular matrix interactions. However, the mechanism inhibiting cell death regulated by CDCP1 remains elusive. Inhibition of CDCP1 expression using small interfering RNA (siRNA) induced the cell death of suspended cancer cells without cleaving caspase-3, a marker of apoptosis; cell death was not inhibited by a general caspase inhibitor, suggesting that the loss of CDCP1 induces caspase-independent cell death. In contrast, knockdown of CDCP1 as well as protein kinase Cδ (PKCδ), a downstream effector of CDCP1, in a suspension culture of lung cancer cells resulted in marked induction of membranous microtubule-associated protein 1 light chain 3 (LC3)-II protein, a hallmark of autophagy, and caused the formation of an autophagosome structure visualized using green fluorescent protein-tagged LC3-II. Expression and phosphorylation of exogenous CDCP1 by Fyn kinase reduced the formation of autophagosomes and inhibited phosphorylation of CDCP1 by PP2, a Src kinase inhibitor or inhibited PKCδ by rottlerin, stimulating autophagosome formation. Moreover, death of suspended lung cancer cells induced by CDCP1 siRNA or by PKCδ siRNA was reduced by the autophagy inhibitor 3-methyladenine. These results indicate that CDCP1-PKCδ signaling plays a critical role in inhibiting autophagy, which is responsible for anoikis resistance of lung cancer cells. PMID:23510015

  18. Application of anchorages in treatment of quality defects of aqueducts%植筋技术在渡槽质量事故处理中的应用

    Institute of Scientific and Technical Information of China (English)

    方业源

    2010-01-01

    五化灌区塘柳渡槽在施工不慎发生槽壁钢筋严重偏移的质量事故,在受到施工工期严格限制的情况下采用植筋技术,弥补了施工缺陷.本文介绍了该质量事故的处理方案、植筋的具体施工工序和需要注意的一些问题,可为工程技术人员处理类似质量事故提供参考.

  19. Transformation of primary human embryonic kidney cells to anchorage independence by a combination of BK virus DNA and the Harvey-ras oncogene

    International Nuclear Information System (INIS)

    Primary human embryonic kidney (HEK) cells were transformed by a focus assay with BK virus (BKV) DNA molecularly cloned at its unique EcoRI site. Both viral DNA sequences and viral tumor antigens were present and expressed in all the foci that the authors examined. However, cells isolated from foci were incapable of growth in soft agar. They then examined the transformation of HEK cells after their transfection with a combination of BKV DNA and either the normal or the activated form of the human Ha-ras oncogene (EJ c-Ha-ras-1). Only the cells transfected with a combination of BKV DNA and the activated form of Ha-ras DNAs were present in the transformed colonies. BKV tumor antigens and the Ha-ras p21 protein were also expressed

  20. Remains of the ancient ports and anchorage points at Miyani and Visawada, on the west coast of India: A study based on underwater investigations

    Digital Repository Service at National Institute of Oceanography (India)

    Gaur, A.S.; Sundaresh; Tripati, S.

    The recent underwater explorations on the Saurashtra coast, Gujarat, India between Miyani on the west and Porbandar on the east yielded the existence two ports at Visawada and Miyani. Both sites are situated along the creeks, which would have served...

  1. Fibronectin has a dual role in locomotion and anchorage of primary chick fibroblasts and can promote entry into the division cycle

    DEFF Research Database (Denmark)

    Couchman, J R; Rees, D A; Green, M R; Smith, C G

    1982-01-01

    microscopy with a colloidal gold marker reveals the presence of small membrane-associated plaques of fibronectin in motile cells with associated submembranous specialization. A fibrillar matrix containing fibronectin is dominant in nonmotile, growing fibroblasts. The development of focal adhesions for...

  2. 微型种植体支抗正畸过程中的稳定性%Stability of mini-implant during orthodontic treatment as anchorage

    Institute of Scientific and Technical Information of China (English)

    石彦涛; 平燕; 单丽华; 宋建设; 邱志香

    2008-01-01

    背景:微型种植体作为绝对支抗应用于正畸治疗中存在的最大问题是稳定性.目的:应用微型种植体支抗内收上颌前牙,观察上颌前牙及第一磨牙位置的变化,评价微型种植体作为强支抗在正畸治疗过程中的稳定性.设计、时间及地点:对比观察实验.于2006-10/2007-12选择河北医科大学第二医院口腔正畸科门诊患者.对象:选取门诊就诊的双颌前突或上颌前突患者20例,男6例,女14例;年龄15-27岁,平均20.7岁.矫治设计拔除4颗第1 双尖牙或上颌第1及下颌第2双尖牙.方法:随机选择10例应用上颌后牙区微螺钉型种植体支抗内收前牙,微型钛钉直径为1.5 mm,长度为8 mm,由西安中邦钛生物制品有限公司提供.所有种植体由同一术者采取相同的手术方式植入.另10 例采用腭杆加口外弓的支抗方法.主要观察指标:治疗前及关闭拔牙间隙后拍摄X射线头颅侧位片,测量前牙内收情况、软组织变化及磨牙支抗的变化.结果:①微型钛钉种植体存拔牙间隙关闭的过程中保持了稳定,成功率89%.②种植体支抗治疗后上中切牙倾角及凸距的减少量明显多于非种植体强支抗治疗后的减少量.差异有显著性意义(P<0.01);种植体支抗组磨牙位移明显少于非种植体强支抗组.差异有显著性意义(P<0.01).结论:微型钛钉种植体作为稳定的骨件正畸支抗,可以实现理想的支抗控制效果.

  3. Mini-implant anchorage in orthodontic treatment related to molar problems%种植体支抗在磨牙矫治中临床应用

    Institute of Scientific and Technical Information of China (English)

    寻春雷; 曾祥龙

    2009-01-01

    目前对磨牙问题的关注和研究使得正畸医生对错牙争机制的认识和矫治设计的理念正在发生某些改变.而针对主要由磨牙问题形成的错牙争畸形进行的磨牙矫治,无论是在设计思想还是矫治手段上,都是一类棘手的难题.近年来,微型种植体支抗技术得到快速发展,有助于在解决这类难题时提供崭新的思路.本文概述种植支抗和磨牙矫治的结合带给正畸设计和治疗理念上的变化.

  4. Orthodontic clinical application of mini- implant anchorage%微小种植体支抗在正畸临床中的应用

    Institute of Scientific and Technical Information of China (English)

    刘鑫; 张云飞

    2009-01-01

    通过对利用微小种植体作为支抗来完成关闭拔牙间隙、推磨牙向远中、压低后牙、压低前牙、解决后牙锁、上颌单侧扩弓、协助导萌、直立或前移磨牙的正畸矫治的描述,介绍了常见的微小种植体支抗在正畸临床的应用方法,以期为正畸医生在临床正确使用微小种植体提供一定的帮助.

  5. 微小种植体支抗手术的护理配合%Nursing Cooperation of Mini-implant Surgery for Orthodontic Anchorage

    Institute of Scientific and Technical Information of China (English)

    张楠楠; 高妍

    2016-01-01

    对47例接受微小种植体支抗手术的患者进行术前、术中和术后护理,探讨微小种植体支抗手术的最佳护理配合措施。做好种植体支抗手术患者的护理配合,可避免伤口感染,促进伤口愈合,并可提高种植支抗手术的成功率。

  6. A Novel Rat Model of Orthodontic Tooth Movement Using Temporary Skeletal Anchorage Devices: 3D Finite Element Analysis and In Vivo Validation

    Directory of Open Access Journals (Sweden)

    Neelambar Kaipatur

    2014-01-01

    Full Text Available The aim of this animal study was to develop a model of orthodontic tooth movement using a microimplant as a TSAD in rodents. A finite element model of the TSAD in alveolar bone was built using μCT images of rat maxilla to determine the von Mises stresses and displacement in the alveolar bone surrounding the TSAD. For in vivo validation of the FE model, Sprague-Dawley rats (n=25 were used and a Stryker 1.2 × 3 mm microimplant was inserted in the right maxilla and used to protract the right first permanent molar using a NiTi closed coil spring. Tooth movement measurements were taken at baseline, 4 and 8 weeks. At 8 weeks, animals were euthanized and tissues were analyzed by histology and EPMA. FE modeling showed maximum von Mises stress of 45 Mpa near the apex of TSAD but the average von Mises stress was under 25 Mpa. Appreciable tooth movement of 0.62 ± 0.04 mm at 4 weeks and 1.99 ± 0.14 mm at 8 weeks was obtained. Histological and EPMA results demonstrated no active bone remodeling around the TSAD at 8 weeks depicting good secondary stability. This study provided evidence that protracted tooth movement is achieved in small animals using TSADs.

  7. 33 CFR 110.150 - Block Island Sound, N.Y.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Block Island Sound, N.Y. 110.150 Section 110.150 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.150 Block Island Sound, N.Y. (a) The anchorage ground. A...

  8. 33 CFR 110.208 - Buffalo Harbor, N.Y.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Buffalo Harbor, N.Y. 110.208 Section 110.208 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.208 Buffalo Harbor, N.Y. (a) The anchorage...

  9. 33 CFR 110.142 - Nantucket Harbor, Mass.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Nantucket Harbor, Mass. 110.142 Section 110.142 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.142 Nantucket Harbor, Mass. (a) The anchorage grounds. In...

  10. 33 CFR 110.138 - Boston Harbor, Mass.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Boston Harbor, Mass. 110.138 Section 110.138 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.138 Boston Harbor, Mass. (a) The anchorage grounds—(1)...

  11. 75 FR 2126 - Regulations Governing the Conduct of Open Seasons for Alaska Natural Gas Transportation Projects...

    Science.gov (United States)

    2010-01-14

    ..., 2010, from 1 p.m. to 5 p.m. (AST) at: Tikhatnu Ballroom D, Anchorage Convention Center, Dena`Ina Civic and Convention Center, 600 West Seventh Avenue, Anchorage, AK 99501. All interested parties may...

  12. 33 CFR 110.205 - Chicago Harbor, Ill.

    Science.gov (United States)

    2010-07-01

    ... boundaries of the anchorage area. (3) Any vessel anchoring under circumstances of great emergency outside of... an established anchorage ground or in stress of weather or to avoid collision, is...

  13. Rock bolt mechanical analysis and its application to engineering

    Institute of Scientific and Technical Information of China (English)

    GUO Ling-yun; XIAO Ming; XIAO Ying-chun

    2008-01-01

    Combined with the 3D FEM, end-anchored anchorage bolts were simulated by implicit anchorage bolt element. Implicit anchorage bolt elements hide in the elements of rock mass and extremely simplify the element subdivision. The calculated value of an-chorage bolt stress is larger than the measured one for the most time. we further analyzed the reciprocity of anchorage bolt and rock mass, and then deduced the analytical equa-tions of anchorage bolt stress and rock mass deformation under elasto-plastic state. The results indicate that it is essential to revise the anchorage bolts stress by using the formu-las deduced when rock mass is softened or significantly deformed. Finally, a case study indicates that the calculated results agree with those measured. Some helpful methods are offerd for more accurate simulation of the support effect and anchorage bolts real stress state.

  14. 76 FR 71321 - North Pacific Fishery Management Council; Public Meetings

    Science.gov (United States)

    2011-11-17

    ... Anchorage Hilton Hotel. DATES: The Council will begin its plenary session at 8 a.m. on Wednesday, December 7... Hilton Hotel, 500 West Third Avenue, Anchorage, AK. Council address: North Pacific Fishery...

  15. 33 CFR 110.229 - Straits of Juan de Fuca, Wash.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Straits of Juan de Fuca, Wash. 110.229 Section 110.229 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.229 Straits of Juan de Fuca, Wash. (a)...

  16. 33 CFR 110.230 - Puget Sound Area, Wash.

    Science.gov (United States)

    2010-07-01

    ... citations affecting § 110.230, see the List of CFR Sections Affected, which appears in the Finding Aids... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Puget Sound Area, Wash. 110.230... ANCHORAGE REGULATIONS Anchorage Grounds § 110.230 Puget Sound Area, Wash. (a) The anchorage...

  17. 33 CFR 110.127 - Lake Mohave and Lake Mead, Nevada and Arizona.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Lake Mohave and Lake Mead, Nevada and Arizona. 110.127 Section 110.127 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.127 Lake Mohave and Lake Mead, Nevada and Arizona. (a) Willow...

  18. 33 CFR 110.255 - Ponce Harbor, P.R.

    Science.gov (United States)

    2010-07-01

    ...) Floats for marking anchors in place will be allowed; stakes or mooring piles are prohibited. 33 CFR Ch. I... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Ponce Harbor, P.R. 110.255... ANCHORAGE REGULATIONS Anchorage Grounds § 110.255 Ponce Harbor, P.R. (a) Small-craft anchorage. On...

  19. 33 CFR 110.156 - Randall Bay, Freeport, Long Island, N.Y.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Randall Bay, Freeport, Long Island, N.Y. 110.156 Section 110.156 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.156 Randall Bay, Freeport, Long Island,...

  20. 33 CFR 110.45 - Onset Bay, Mass.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Onset Bay, Mass. 110.45 Section 110.45 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.45 Onset Bay, Mass. Northerly of a line extending...

  1. 33 CFR 110.27 - Lynn Harbor in Broad Sound, Mass.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Lynn Harbor in Broad Sound, Mass. 110.27 Section 110.27 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.27 Lynn Harbor in Broad Sound, Mass. North...

  2. 33 CFR 110.38 - Edgartown Harbor, Mass.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Edgartown Harbor, Mass. 110.38 Section 110.38 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.38 Edgartown Harbor, Mass. An area in the inner...

  3. 33 CFR 110.29 - Boston Inner Harbor, Mass.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Boston Inner Harbor, Mass. 110.29 Section 110.29 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.29 Boston Inner Harbor, Mass. (a) Vicinity of...

  4. 33 CFR 110.32 - Hingham Harbor, Hingham, Mass.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Hingham Harbor, Hingham, Mass. 110.32 Section 110.32 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.32 Hingham Harbor, Hingham, Mass. (a) Area...

  5. 33 CFR 110.37 - Sesuit Harbor, Dennis, Mass.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Sesuit Harbor, Dennis, Mass. 110.37 Section 110.37 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.37 Sesuit Harbor, Dennis, Mass. All the...

  6. 33 CFR 110.186 - Port Everglades, Florida.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Port Everglades, Florida. 110.186... ANCHORAGE REGULATIONS Anchorage Grounds § 110.186 Port Everglades, Florida. (a) The anchorage grounds. The... entrance to Port Everglades, is an area bounded by a line connecting points with the following...

  7. 33 CFR 110.71 - Jacobs Nose Cove, Elk River, Md.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Jacobs Nose Cove, Elk River, Md... ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.71 Jacobs Nose Cove, Elk River, Md. The water area of Jacobs Nose Cove, on the west side of the mouth of Elk River, Maryland, comprising the...

  8. 底板设置锚筋的圆形水泵房内力分析研究和实践%Inner Force Analytic Research and Practice of the Circular Pump House to Install Anchorage on Motherboard

    Institute of Scientific and Technical Information of China (English)

    陈惠明

    2003-01-01

    在岩基和水深较大的位置修筑水泵房时,在底板设置锚筋,对泵房抗浮、改善泵房内力分布,利用自然条件降低工程造价,起到较好的作用.对底板设置锚筋的圆形水泵房进行内力分析研究,并在来宾电厂水泵房中应用,取得很好的效果.

  9. GFRP锚杆结构预应力锁定装置研制与现场试验%Development of load anchorage device for pre-stress GFRP soil nail reinforcement element in slopes and field tests

    Institute of Scientific and Technical Information of China (English)

    刘龙; 李国维; 贺冠军; 余亮; 刘学

    2015-01-01

    The fiber reinforced polymer (FRP) bars have the behavior of strong corrosion resistance, high tensile strength and small elastic modulus, and can be used to replace steel bars, which undergo wearing due to rusting in slope reinforcement. The pre-stress FRP bars are reasonable, but the bars have low shear strength and cannot be pre-stressed using the traditional rigid clamp, lest they are crashed to failure. An end anchoring pre-stress locking device is designed for pre-stress application and retention in the FRP bars. Field tests are conducted to verify the stability of the device. The test results show that the device is practically feasible and convenient, and it can apply and retain pre-stress in basalt-glass fiber reinforced polymer (B-GFRP) bars well. Exposure to external factors such as heavy rains and blasting results in the loss of pre-stress. The pre-stress loss is caused by degeneration of the bonding resulting from external factors, but not by the invalidation of the device. The pre-stress retention by the device in the B-GFRP bars is 5%~35%, which conforms to the control criterion for the pre-stress loss of the steel pre-stressed soil nail reinforcement.%纤维增强聚合物(FRP)筋耐腐蚀,抗拉强度高,弹性模量小,用于边坡加固锚杆结构是解决钢筋锚杆结构耐久性问题的途径之一,预应力FRP锚杆结构是合理型式。FRP筋抗剪强度低,钢筋锚杆施加预应力采用的刚性夹具不能用于FRP锚杆。基于端部封闭的钢套管充填膨胀剂锚固FRP筋法,设计了FRP锚杆预应力施加及锚索装置,并进行了现场试验。试验结果表明:预应力锁定装置的原理可行,结构合理,使用方便,能较好地完成玄武–玻璃纤维增强聚合物(B-GFRP)锚杆的预应力施加和锁定,经历外部环境变化检验,降雨、震动等环境影响产生的预应力损失均缘于杆体界面的黏结蜕化,没有发生锁定装置失效导致荷载明显损失的现象。B-GFRP锚杆的预应力损失百分率在5%~35%间,达到了精轧螺纹钢锚杆预应力损失的控制标准。

  10. Orthodontic treatment of condylar fracture in children with implant anchorage%固定矫治器联合种植体支抗正畸治疗儿童髁突骨折

    Institute of Scientific and Technical Information of China (English)

    林有籁; 午君武; 郑松

    2013-01-01

    目的 观察正畸固定矫治器联合种植体支抗牵引固定儿童髁突骨折的治疗效果.方法 选取年龄为7~18岁,临床确诊为儿童髁突骨折的病例8例.即刻粘结正畸固定矫治器,植入种植体支抗,上颌间接支抗联合颌间牵引固定复位.结果 所有患者经治疗后均取得良好的临床疗效.张口度,咬合关系,咀嚼功能恢复正常,颌面部发育正常.全景片示髁突骨折逐渐恢复.结论 正畸固定矫治器联合种植体支抗牵引固定是临床上一种有效的治疗儿童髁突骨折的方法.

  11. A preliminary overview of skin and skeletal diseases and traumata in small cetaceans from South American waters. SC/59/DW4, International Whaling Commission/SC, Anchorage, Alaska, May 2007

    OpenAIRE

    Van Bressem, M.-F.; Van Waerebeek, K.; Reyes, J; Félix, F.; M. Echegaray; Siciliano, S.; Di Beneditto, A.P.; Flach, L.; Viddi, F.; Avila, I.C.; Bolaños, J.; Castineira, E.; Montes, D.; Crespo, E.; Flores, P. A. C.

    2007-01-01

    Miscellaneous lesions of the skin and skeletal system, and external traumata were observed in 558 of 7,400 specimens of 12 odontocete species from the waters of Colombia, Ecuador, Peru, Chile, Argentina, Uruguay, Brazil and Venezuela examined in 1984-2007. Tattoo skin disease (TSD), lobomycosis-like and cutaneous diseases of unknown aetiology seem to be emerging in several populations and, in some cases, may be associated with chemical and organic water pollution. TSD was observed in eight sp...

  12. EXPERIMENTAL STUDY ON SAND CONSOLIDATED ANCHORAGE PRESTRESSED BOLT AND ITS APPLICATIONS%砂固结内锚头预应力锚杆试验研究及应用

    Institute of Scientific and Technical Information of China (English)

    覃卫民; 葛修润; 王浩

    2007-01-01

    为将砂固结内锚头预应力锚杆推广应用到锚固工程中,在长江三峡工程砂石料场及湖南凤滩电站地下厂房开展应用试验研究.通过三峡工程砂石料场边坡12根(φ) 32 mm高强材质锚杆现场试验研究,提出此类锚杆的设计方法和施工工艺,对其锚固的长期稳定性进行预应力监测.根据凤滩电站工程实际情况进行技术创新,研究出一种刚性封口的新型砂固结内锚头预应力锚杆,获得国家专利局授权发明专利.

  13. TESTING STUDY AND NUMERICAL SIMULATION ON SAND-CONSOLIDATED-ANCHORAGE-PRESTRESSED BOLT%砂固结预应力锚杆的试验及其数值模拟

    Institute of Scientific and Technical Information of China (English)

    陈荣; 彭伟东; 尹建华; 胡正东; 葛修润; 丰定祥

    2000-01-01

    砂固结预应力锚杆的锚固力是由砂体与锚孔壁之间的摩擦力提供的. 设计了室内试验和现场试验, 并对这项技术作了深入地研究. 基于室内试验成果, 对现场试验作了数值模拟分析.

  14. An archaeological site survey and inventory for the Aleutian Islands National Wildlife Refuge, Alaska 1972: A report submitted to the Wilderness Studies Branch, U.S. Fish and Wildlife Service, Anchorage, Alaska

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report summarizes a 1972 voyage in the Aleutian archipelago to locate prehistoric and historic archeological sites. The report centers on the problems...

  15. 隧道锚围岩拉拔模型试验研究及数值模拟%Pull-out model test for tunnel anchorage and numerical analysis

    Institute of Scientific and Technical Information of China (English)

    胡波; 赵海滨; 王思敬; 刘海宁; 彭运动; 刘晓丽; 张晓平

    2009-01-01

    采用现场模型试验同FLAC3D数值试验相结合进行对比研究.介绍了坝陵河大桥西锚碇1:20、1:30现场模型试验,研究发现锚碇横截面位移呈马鞍型,向两端逐渐收敛,轴线方向呈梯形分布,围岩残余变形率呈V形分布,相同应力水平下,大尺寸模型的监测位移较大.数值试验发现,应力分布具有明显的分段特征,沿锚体呈不对称分布,可能的破坏方式是锚体带动周边一定范围岩体发生塞体状的整体拉剪复合破坏.设计和施工过程中应对显著变形区及破损区内的岩体进行重点加固.

  16. Three-dimensional finite element analysis on mini-implants for orthodontic anchorage%正畸微种植体支抗的三维有限元研究进展

    Institute of Scientific and Technical Information of China (English)

    于海璐; 蔡兴伟; 李涛

    2016-01-01

    近年来,微种植体支抗在口腔正畸临床实践中的应用逐渐增多.与传统支抗相比,微种植体支抗体积较小且相对价格低廉、操作简便,能够解决更多疑难病例,但却仍然存在一定的失败率.为了进一步提高其稳定性,本文对国内外学者关于微种植体结构设计、骨质量、植体材料、正畸力载荷以及植入角度的有限元研究进行综述,进一步明确这些因素对于微种植体稳定性的影响,为微种植体支抗能够更加高效的应用于临床提供依据.

  17. Orthodontic treatment for gum-smile with mini-implant anchorage by maxillary anterior teeth intrusion%应用微种植体支抗压低上前牙改善露龈笑的临床研究

    Institute of Scientific and Technical Information of China (English)

    刘名燕; 任娟; 周斌; 冯云霞

    2014-01-01

    目的 探讨上颌前牙区微种植体支抗压低上前牙改善露龈笑的临床疗效.方法 选择露龈笑伴深覆殆患者15例,平均年龄(19.7±5.4)岁,在位于12,22近中根尖处颌骨内各植入1颗微种植钉,在方丝12,22近中置游离拉钩,向微种植钉做弹性牵引,每侧加力0.6N,平均加力压低的时间为(6.2±1.6)个月.测量矫治前后X线头颅侧位片的相关软硬组织指标,使用SPSS 13.0软件进行统计分析.结果 前牙垂直压低的量及切牙牙冠长度明显减少(P<0.01),磨牙伸长量不显著.前牙的覆殆与覆盖均矫治达到正常范围.结论 微种植体做支抗压低上前牙、纠正深覆黯效果理想,能有效改善露龈笑.

  18. 微型种植体支抗在青少年口腔正畸治疗中的效果及安全性%Efficacy and Safety of Mini Implant Anchorage in Orthodontic Treatment of Adolescents

    Institute of Scientific and Technical Information of China (English)

    孙洁; 邓立兰; 凌燕; 魏永亮; 史聪翀

    2016-01-01

    目的:研究微型种植体支抗治疗青少年口腔正畸的疗效及安全性.方法:选择2013年5月-2015年5月在我院接受治疗的80例青少年口腔正畸患者,随机分为试验组和对照组.试验组给予微型种植体支抗治疗,对照组给予传统正畸治疗.观察并比较两组患者的临床疗效、不良反应及头影测量结果.结果:试验组患者的上、中切牙倾角差、上中切牙凸距差、磨牙移位的改善情况均明显高于对照组,差异有统计学意义(P<0.05);与治疗前比较,两组患者治疗后U1-L1、U1-SN、L1-MP、U1-NA、L1-NB、SNA、SNB及ANB差值均有统计学意义(P<0.05);试验组U1-L1、SNB显著大于对照组,其他指标均显著小于对照组,差异具有统计学意义(P<0.05);试验组患者不良反应的发生率明显低于对照组,差异具有统计学意义(P<0.05).结论:与传统支抗方法相比,微型种植体支抗用于青少年口腔正畸治疗具有操作简便、疗效显著、安全性较高等优点,适合在临床推广使用.

  19. Effect of Orthodontic Mini-implant Anchorage on Masticatory Function Of Malocclusion Patients%微型种植钉支抗法正畸对错(牙合)畸形患者咀嚼功能的影响

    Institute of Scientific and Technical Information of China (English)

    纪芳; 刘宝君; 陶疆

    2009-01-01

    [目的]研究微型种植钉支抗正畸矫治错(牙合)畸形患者手术前后咀嚼功能的变化.[方法]选择安氏Ⅱ类伴上颌前突患者24例,用微型种植钉加强支抗,分别测定治疗前后的吞咽起始时间以及治疗前后的咀嚼效率.[结果]①24例中21例微型种植钉成功作为加强支抗完成治疗,磨牙前移轻微,切牙后移明显,成功率为87.5%;②矫治前后吞咽开始时间的减少值和咀嚼效率的改善值相比均有统计学意叉(P<0.05).[结论]微型种植钉支抗法正畸成功率高,能够有效改善错(牙合)畸形患者的咀嚼功能.

  20. Clinical application of mini-screw implant anchorage for anterior teeth retraction orthodontic treatment%微型种植体支抗在内收前牙正畸治疗中的临床应用

    Institute of Scientific and Technical Information of China (English)

    安志良; 胡玉柱; 詹颖; 张朝晖; 刘志利

    2008-01-01

    目的 评价微螺钉种植体在正畸治疗中作为支抗内收前牙的有效性.方法 选择双颌前突和上颌前突的患者共19例,应用上、下颌后牙区微螺钉种植体作为支抗内收前牙.在治疗前后拍摄头颅定位侧位片,以SN为基准重叠治疗前、后头影测量描记图,观察第一磨牙的位置改变.治疗结束后观察患者前牙覆(牙合)覆盖关系和Ⅱ类磨牙关系的改变,以及面型凸度的改善程度.结果 19例患者中16例患者应用微螺钉种植体支抗顺利完成正畸治疗,均建立了正常的前牙覆(牙合)覆盖关系,成功纠正了Ⅱ类磨牙关系,面型凸度明显改善,第一磨牙位置稳定.结论 国产微螺钉种植体支抗与传统的强支抗方式相比,确保磨牙支抗不丧失的能力更强,几乎达到绝对支抗的能力,可以实现理想的支抗控制.

  1. Nursing experience on insertion of self-tapping mini-implant for orthodontic anchorage%自攻式微种植支抗钉植入术护理体会

    Institute of Scientific and Technical Information of China (English)

    林洁; 赵佛容

    2012-01-01

    目的 探讨自攻式微种植钉植入手术的护理要点.方法 150例需要植入微种植支抗钉病例,于齿槽骨或颌骨内植入自攻式微种植钉.在手术前进行心理护理和用物准备;术中配合医生操作,安抚患者;术后对患者进行饮食、口腔卫生等指导.结果 150例患者共植入322颗自攻式微种植钉,成功304颗,失败18颗,成功率94.4%.结论 正确的医护配合及术前术后的卫生宣教,既能减少感染的发生,也助于提高微种植支抗钉植入手术的成功率.

  2. Clinical outcome evaluation of midpalatal mini-implant anchorage system in orthodontic treatment%腭中部微种植钉支抗系统的临床效果评价

    Institute of Scientific and Technical Information of China (English)

    潘一春; 赵健慧

    2014-01-01

    目的:初步探讨腭中部微种植钉支抗系统在固定矫治中的支抗效果,为正畸临床支抗的选择提供参考.方法:选择骨性Ⅰ、Ⅱ类需上颌强支抗的青少年正畸患者14例作为研究对象,均采用双颌固定矫治器进行正畸治疗,在上颌减数两颗第一双尖牙并在腭中线旁、第一磨牙水平植入微种植钉一颗.以0.019 inch×0.022 inch(1inch =2.54 cm)的不锈钢方丝横腭杆固定连接微种植钉和双侧上颌第一磨牙,组成一个腭中部微种植钉支抗系统进行正畸力的负载,下牙列不纳入研究.植入微种植钉时(T0)、上颌间隙关闭或基本关闭时(T1)分别拍摄头颅侧位片进行头影测量描图.分别采用SN-7平面及PP平面作为参考平面,对微种植钉以及上颌第一磨牙在T0、T1的位置差异进行头影测量分析.采用配对t检验进行统计学分析.结果:腭中部微种植钉植入后的临床成功率为73.9%.14例进行测量分析的病例中,微种植系统负载正畸力后仍保持稳固,双侧第一磨牙没有发生明显的近中移动.微种植钉以及上颌第一磨牙的位置变化在两组间的差异没有统计学意义.结论:本研究中设计的腭中部微种植支抗系统具有较好的稳定性,在正畸治疗中能够起到强支抗的作用,可作为一种正畸强支抗的可选方案在临床中应用.

  3. 正畸微种植体支抗功能期的护理%Postoperative nursing of patients accepting mini-implants for orthodontic anchorage in functional period

    Institute of Scientific and Technical Information of China (English)

    李珩; 张安翔; 雷逸灵

    2009-01-01

    @@ 近年来,种植支抗在正畸临床中正广泛推广应用[1].与传统支抗手段相比,微种植体支抗减少了病人的不适感,可实现对支抗的有效控制,应用安全、隐蔽、疗程短、植入方法简单和价格较低,在我国已迅速普及开展[2,3].

  4. Molecular mechanisms of the 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced inverted U-shaped dose responsiveness in anchorage independent growth and cell proliferation of human breast epithelial cells with stem cell characteristics

    International Nuclear Information System (INIS)

    Although 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has a variety of carcinogenic and noncarcinogenic effects in experimental animals, its role in human carcinogenicity remain controversial. A simian virus 40-immortalized cell line from normal human breast epithelial cells with stem cells and luminal characteristics (M13SV1) was used to study whether TCDD can induce AIG positive colony formation and cause increased cell numbers in a inverted U-shaped dose-response manner. TCDD activated Akt, ERK2, and increased the expression of CYP1A1, PAI-2, IL-lb mRNA, and ERK2 protein levels. TCDD was able to increased phosphorylation and expression of ERK2 in same dose-response manner as AIG positive colony formation. Thus, TCDD induced tumorigenicity in M13SV1, possibly through the phosphorylation of ERK2 and/or Akt. Further, cDNA microarray with 7448 sequence-verified clones was used to profile various gene expression patterns after treatment of TCDD. Three clear patterns could be delineated: genes that were dose-dependently up-regulated, genes expressed in either U-shape and/or inverted U-shape. The fact that these genes are intrinsically related to breast epithelial cell proliferation and survival clearly suggests that they may be involved in the TCDD-induced breast tumorigenesis

  5. 33 CFR 110.74a - Manatee River, Bradenton, Fla.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Manatee River, Bradenton, Fla... ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.74a Manatee River, Bradenton, Fla. The waters of the Manatee River enclosed by a line beginning at latitude 27°31′18.6″ N. longitude 82°36′49.2″...

  6. 33 CFR 110.81 - Muskegon Lake, Mich.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Muskegon Lake, Mich. 110.81... ANCHORAGE REGULATIONS Special Anchorage Areas § 110.81 Muskegon Lake, Mich. (a) Muskegon Lake West. The waters of the southwest side of Muskegon Lake enclosed by a line beginning at latitude 43°13′24″...

  7. 76 FR 28776 - Re-Proposal of Effluent Limits Under the NPDES General Permit for Oil and Gas Exploration...

    Science.gov (United States)

    2011-05-18

    ... Alaska Department of Environmental Conservation (ADEC) on May 3, 2011. EPA intends to seek a final certification from ADEC prior to issuing the final Permit. When the State issues certification, the State may.../Permits+Homepage . (4) ADEC Anchorage office, 555 Cordova Street, Anchorage, AK 99501-2617. (5) ADEC...

  8. Effectiveness of Mini Implants in Three-Dimensional Control During Retraction - A Clinical Study

    OpenAIRE

    Victor, Deepak; Prabhakar, Ramchandra; Karthikeyan, M.K.; R.Saravanan; Vanathi, P.; Vikram, N. Raj; Reddy, P. Adarsh; Sudeepthi, M.

    2013-01-01

    Introduction: Three-dimensional control throughout the orthodontic treatment is essential for uncompromised results. Mini screws introduced for orthodontic anchorage has given the clinician an option of absolute three dimensional control. The purpose of this study was to compare and measure the vertical control and torque control of incisors and molar during enmass retraction with titanium microimplants and conventional molar anchorage.

  9. Mechanical mechanism analysis of tension type anchor based on shear displacement method

    Institute of Scientific and Technical Information of China (English)

    XIAO Shu-jun; CHEN Chang-fu

    2008-01-01

    Based on the fact that the shear stress along anchorage segment is neither linearly nor uniformly distributed, the load transfer mechanism of the tension type anchor was studied and the mechanical characteristic of anchorage segment was analyzed. Shear stress-strain relationship of soil surrounding anchorage body was simplified into three-folding-lines model consisting of elastic phase, elasto-plastic phase and residual phase considering its softening eharaeteristic. Meanwhile, shear displacement method that has been extensively used in the analysis of pile foundation was introduced. Based on elasto-plastic theory, the distributions of displacement, shear stress and axial force along the anchorage segment of tension type anchor were obtained, and the formula for calculating the elastic limit load was also developed accordingly. Finally, an example was given to discuss the variation of stress and displacement in the anchorage segment with the loads exerted on the anchor, and a program was worked out to calculate the anchor maximum bearing capacity. The influence of some parameters on the anchor bearing capacity was discussed, and effective anchorage length was obtained simultaneously. The results show that the shear stress first increases and then decreases and finally trends to theresidual strength with increase of distance from bottom of the anchorage body, the displacement increases all the time with theincrease of distance from bottom of the anchorage body, and the increase of velocity gradually becomes greater.

  10. 78 FR 42757 - Marine Mammals; File No. 17411

    Science.gov (United States)

    2013-07-17

    .... Jennifer Burns, University of Alaska Anchorage, Biology Department, Anchorage, AK, to conduct research on... (78 FR 14984) that a request for a permit to conduct research on Weddell seals (Leptonychotes... National Oceanic and Atmospheric Administration RIN 0648-XC541 Marine Mammals; File No. 17411...

  11. 78 FR 14984 - Marine Mammals; File No. 17411

    Science.gov (United States)

    2013-03-08

    ..., University of Alaska Anchorage, Biology Department, Anchorage, AK, has applied in due form for a permit to... National Oceanic and Atmospheric Administration RIN 0648-XC541 Marine Mammals; File No. 17411 AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric Administration (NOAA),...

  12. 33 CFR 110.159 - Annapolis Harbor, MD.

    Science.gov (United States)

    2010-07-01

    ... structures, and mooring and anchorage of vessels in anchorages (a)(3), and (a)(5). These local ordinances... area, lying between the Naval Academy and the Naval Ship Research and Development Laboratory and having... Naval Ship Research and Development Laboratory; northwestern limit, a line bearing 054° from the...

  13. 33 CFR 110.25 - Salem Sound, Mass.

    Science.gov (United States)

    2010-07-01

    ... described in 33 CFR 110.25(a) to the point of beginning. (f) Marblehead Harbor, Marblehead, MA. The area... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Salem Sound, Mass. 110.25 Section... ANCHORAGE REGULATIONS Special Anchorage Areas § 110.25 Salem Sound, Mass. (a) Beverly Harbor, north of...

  14. 33 CFR 110.30 - Boston Harbor, Mass.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Boston Harbor, Mass. 110.30... ANCHORAGE REGULATIONS Special Anchorage Areas § 110.30 Boston Harbor, Mass. (a) Vicinity of South Boston... the local Harbor Master, Hull, Mass. (m) Hingham Harbor Area 1. Beginning at position latitude...

  15. Calculation of shear strength of prestressed hollow core slabs by use of plastic theory

    DEFF Research Database (Denmark)

    Hoang, Linh Cao; Jørgensen, H.G.; Nielsen, Mogens Peter

    2014-01-01

    saw-cut into units with the desirable length. For this reason, hollow core slabs are usually not shear reinforced and anchorage of the prestressing strands has to be established by bond. Hollow core slabs may therefore be more critical to shear and anchorage failure than ordinary two-way spanning...... reinforced concrete slabs....

  16. Test on Beams Strengthened with Multi-layers Carbon Fiber Sheets Anchored by Wave-shaped-gear-grip Anchorage%锚固多层碳纤维布加固钢筋混凝土梁的试验研究

    Institute of Scientific and Technical Information of China (English)

    卓静; 李唐宁; 章庆学; 周密

    2006-01-01

    为了进一步验证采用波形齿夹具锚锚固碳纤维布可以完全避免碳纤维布端部的剥离破坏,分别对采用粘贴4,6,8,10层碳纤维布加固的4根钢筋混凝土梁进行了抗弯加载试验.试验结果表明,由于采用了波形齿夹具锚作为碳纤维布的端部锚固措施,尽管粘贴的碳纤维布层数较多,并且碳纤维布的粘贴质量也较差,然而抗弯加固的碳纤维布都没有出现端部的剥离失效问题,并且碳纤维布的强度也得到了较充分的发挥.

  17. LABORATORY TESTING STUDY ON SAND-CONSOLIDATED- ANCHORAGE-PRESTRESSED BOLT AND NEW SUGGESTION ON SAND STRENGTH THEORY%砂固结锚固室内试验及砂土强度特性理论的再认识

    Institute of Scientific and Technical Information of China (English)

    陈荣; 邓学璟; 胡正东; 葛修润; 丰定祥

    2000-01-01

    砂固结内锚头预应力锚杆的锚固力是由砂体与锚孔壁之间的摩擦力提供的,设计的室内试验测出了摩擦力的分布曲线,基于本试验成果对目前的砂土强度特性理论提出了一些看法.

  18. The Clinical Application of Mini-screw Implant Anchorage in the orthodontic Treatment Of Adult Bimaxillary Protrusion%微螺钉种植体支抗在成人双颌前突正畸治疗中的临床应用

    Institute of Scientific and Technical Information of China (English)

    赵红卫; 杨雨民

    2010-01-01

    目的:总结微螺钉种植体支抗在临床中治疗成人双颌前突的经验,评价微螺钉种植体在正畸治疗中作为强支抗内收前牙的有效性.方法:从临床病例中选择12例成人双颌前突患者,矫治设计均为拔除4颗第一前磨牙,在上下颌第一恒磨牙与第二恒磨牙或上下颌第一恒磨牙与第二前磨牙之间的颊侧根尖部植入微螺钉种植体作为强支抗,共48颗,以每侧200g力滑动法关闭间隙.在治疗前后均拍摄头颅定位侧位片及全颌曲面断层片,比较双颌前突患者治疗前后前牙内收情况及第一恒磨牙位置的变化.结果:12例成人双突患者面型均得到明显改善,应用微螺钉种植体支抗顺利完成正畸治疗,第一恒磨牙位置稳定.结论:微螺钉种植体支抗可避免上颌磨牙的前移,能为上下颌前突畸形的矫治提供有效的支抗.

  19. 种植体支抗辅助非拔牙矫正成人Ⅱ类2分类错(牙合)的临床研究%Clinical study of non-extraction orthodontic treatment for adult Angle's Ⅱ Division 2 malocclusion assisted by mini-screw implant anchorage

    Institute of Scientific and Technical Information of China (English)

    冯贻苗; 万澎波; 娄新田; 王一霖

    2014-01-01

    目的 探讨微型种植体支抗辅助矫治成人安氏Ⅱ类2分类错(牙合)的临床作用机制.方法 选择12例安氏Ⅱ类2分类病例,男4例,女8例,年龄18~38岁,平均21.0岁.应用微型种植体支抗牵引上牙列整体向后移动,压低上前牙,分析治疗前后患者牙齿、颌骨及软组织变化.结果 上颌中切牙矢状向牙冠基本保持不动,牙根平均远中移动3.63 mm,平均倾斜比率为6050%,牙冠压低4.60 mm.上颌第一前磨牙牙冠平均远中移动3.25 mm,牙根远中移动3.65 mm,平均倾斜比率为112.3%,牙冠压低2.90 mm.上颌第一磨牙牙冠平均远中移动3.11 mm,牙根远中移动3.21 mm,平均倾斜比率为103.2%,牙冠压低1.17 mm.上颌第二磨牙牙冠平均远中移动3.22 mm,牙根平均远中移动3.15 mm,平均倾斜比率为97.8%,压低0.69 mm.结论 运用微型种植体支抗可以有效地使上颌牙列整体后移、压低上前牙并改建上颌前牙区齿槽骨形态,是非拔牙矫正安氏Ⅱ类内倾型深覆(牙合)患者的有效方法.

  20. Light microscopic observation on immediate and early loading of mini screw implants used for orthodontic anchorage in Beagle dogs%Beagle犬上颌骨微钛螺纹钉种植体支抗即刻和早期加载的光镜观察

    Institute of Scientific and Technical Information of China (English)

    孙嵘; 范春香; 吴丽萍

    2009-01-01

    目的 通过光镜观察不同加载时间及加载力值对微钛螺纹钉种植体-骨结合界面的影响.方法 将90枚微钛螺纹钉种植体(mini screw implant, MSI)分为9组,植入5只Beagle犬的上颌骨.分别于即刻、第2周、第4周、第8周加载100 g或300 g的水平力,对照组不加力.第20周处死动物取材.垂直于种植体长轴方向切片,制成50 μm左右的硬组织切片,苦味酸-品红染色,在光学显微镜下观察种植体-骨结合界面的密合程度并计算种植体-骨结合率.结果 本实验共有9枚MSI松动.其余MSI在光镜下显示与骨组织直接接触,未见纤维组织长入.各组MSI与周围骨组织的平均骨结合率为(45.28±23.89)%.各组间骨结合率差别无统计学意义.结论 在一定骨质及初期稳定性的保证下,在Beagle犬的上颌骨MSI即刻加载300 g以内的水平力是可行的.

  1. 微小种植体支抗与传统强支抗在成人双颌前突尖牙远移中的比较%Comparative study of mini-implant for orthodontic anchorage and traditional anchorge in cuspid retration in adult patients with bimaxillary protrusion

    Institute of Scientific and Technical Information of China (English)

    刘鑫; 段银钟; 刘岚

    2004-01-01

    目的:研究微小种植体在成人双颌前突矫治尖牙远移中的支抗应用,同时与口外弓配合Nance弓的传统支抗相比较.方法:24例成人双颌前突患者随机分为2组,试验组尖牙远移时应用微小种植体做为支抗,对照组远移尖牙时则利用口外弓配合Nance弓的传统支抗,通过尖牙远移前后的X线头影测量变化来判断2支抗丧失情况并做组间比较.结果:2组患者在3~6个月后远移尖牙到位,试验组上颌第一磨牙前移0.85mm,上切牙腭侧移动1.82mm对照组上颌第一磨牙前移0.91mm,上切牙腭侧移动2.02mm.方差分析可见2组间无差异.结论:微小种植体是一种具有稳固、生物相容性好、舒适等特点的支抗,完全可以代替口外弓配合Nance弓的传统强支抗,在尖牙远移过程中发挥强大的支抗作用.

  2. 微种植支抗关闭正畸拔牙间隙对下颌垂直向位置的影响%Influence to the mandibular plane in vertical dimension in extraction-orthodontic treatment applying mini-implant anchorage

    Institute of Scientific and Technical Information of China (English)

    李建军; 施生根

    2013-01-01

    目的 分析应用微种植支抗关闭正畸拔牙间隙对下颌垂直向位置的影响.方法 选择2008年1月~2011年12月解放军306医院患者20例,将应用微种植支抗的高角正畸拔牙患者进行5项与下颌垂直位置有关的指标测量,对治疗前后指标进行统计学分析.结果 上颌中切牙(U1)治疗前后[(33.01±2.43)、(30.70±2.53) mm]垂直向位置变化具有高度统计学意义(P<0.01);上颌第一磨牙(U6)平均压低治疗前后[(23.93±1.99)、(22.78±2.02) mm]垂直向位置变化具有统计学意义(P<0.05);治疗前后下颌平面角及合平面角(GOGN-SN、FMA、Occp-FH)变化差异具有统计学意义(P<0.05).结论 种植支抗辅助高角拔牙正畸治疗后,上颌中切牙及上颌第一磨牙呈现一定程度压低,下颌平面角及合平面角减小,下颌产生一定程度逆时针旋转.

  3. The animal experiment on the stability of mini-screws anchorage implant under different orthodontic force%不同受力条件下微螺钉支抗种植体稳定性的动物实验研究

    Institute of Scientific and Technical Information of China (English)

    石咏梅; 王翔; 王虎中; 郭家平; 彭艳芳

    2005-01-01

    目的:探讨微螺钉支抗种植体在不同受力条件下的稳定性.方法:观察在300 g力值下,以微型螺钉种植体为支抗,牵拉犬上下颌尖牙;在150 g力值下压低上颌前牙;在300 g、400 g、600 g逐渐加力和600 g即刻加力情况下,种植体交互牵引.观察尖牙横向位移、前牙压低位移以及微螺钉支抗种植体的相互位移情况.结果:种植体拉尖牙移动、压低前牙有效.在600 g力的条件下种植体发生相互位移,并有部分种植体发生松动.结论:微螺钉种植体支抗的稳定性与受力大小有关.

  4. Dual Aurora A and JAK2 kinase blockade effectively suppresses malignant transformation

    OpenAIRE

    Hua YANG; Lawrence, Harshani R.; Kazi, Aslamuzzaman; Gevariya, Harsukh; Patel, Ronil; Luo, Yunting; Rix, Uwe; Schonbrunn, Ernst; Lawrence, Nicholas J.; Sebti, Said M.

    2014-01-01

    Aurora A and JAK2 kinases are involved in cell division and tumor cell survival, respectively. Here we demonstrate that ectopic expression of Aurora A and JAK2 together is more effective than each alone at inducing non-transformed cells to grow in an anchorage-independent manner and to invade. Furthermore, siRNA silencing or pharmacological inhibition of Aurora A and JAK2 with Alisertib and Ruxolitinib, respectively, is more effective than blocking each kinase alone at suppressing anchorage-d...

  5. Movimentação ortodôntica com mini-implantes: relato de caso clínico

    Directory of Open Access Journals (Sweden)

    Jean Cleiton Buchmann Machado

    2011-01-01

    conventional anchorage would produce limitations in the treatment. The purpose of this paper is to describe a case report of a adult female, with skeletal Class II, an upper dental midline deviation to the left, with fixed bridge from 23 to 26 and the absence of the 14 and the 15. For the current treatment a mini screw was used as absolute anchorage and a niquel titanium closed coil for distalizing mechanics. The objective of this article is to show the importance of mini screws for anchorage associated with fixed appliances.

  6. Opposing activities of the Ras and Hippo pathways converge on regulation of YAP protein turnover

    DEFF Research Database (Denmark)

    Hong, Xin; Nguyen, Thanh Hung; Chen, Qingfeng;

    2014-01-01

    Cancer genomes accumulate numerous genetic and epigenetic modifications. Yet, human cellular transformation can be accomplished by a few genetically defined elements. These elements activate key pathways required to support replicative immortality and anchorage independent growth, a predictor of...

  7. ARCTIC FOUNDATIONS, INC. FREEZE BARRIER SYSTEM - SITE TECHNOLOGY CAPSULE

    Science.gov (United States)

    Arctic Foundations, Inc. (AFI), of Anchorage, Alaska has developed a freeze barrier technology designed to prevent the migration of contaminants in groundwater by completely isolating contaminant source areas until appropriate remediation techniques can be applied. With this tec...

  8. ARCTIC FOUNDATIONS, INC. FREEZE BARRIER TECHNOLOGY; INNOVATIVE TECHNOLOGY EVALUATION REPORT

    Science.gov (United States)

    Arctic Foundations, Inc. (AFI), of Anchorage, Alaska has developed a freeze barrier technology designed to prevent the migration of contaminants in groundwater by completely isolating contaminant source areas until appropriate remediation techniques can be applied. With this tech...

  9. 30 CFR 250.415 - What must my casing and cementing programs include?

    Science.gov (United States)

    2010-07-01

    ... effect, proper anchorage, and well control. (e) A statement of how you evaluated the best practices included in API RP 65, Recommended Practice for Cementing Shallow Water Flow Zones in Deep Water...

  10. Formuleren onderzoeksvraag en theoretische verankering

    NARCIS (Netherlands)

    Bijker, Monique; Wetzels, Sandra

    2012-01-01

    Bijker, M. M., & Wetzels, S. A. J. (2012, 10 July). Formuleren onderzoeksvraag en theoretische verankering [Formulating a research question and its anchorage in theory]. Presentation given in project 'Professionaliseringstraject: onderzoeksvaardigheden van docenten' of Fontys MER, Eindhoven, The Net

  11. ATLAS Civil Engineering Point 1

    CERN Multimedia

    Jean-Claude Vialis

    2001-01-01

    Different phases of realisation to Point 1: zone of the ATLAS experiment 14-02-2001Realising anchorage, isolations and scaffoldings at UX 15 18-04-2001Concreting the arch and posing the metal reinforcements at UX 15

  12. Elmendorf-Fort Richardson cooperative moose research project

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report summarizes the findings of a moose study to establish scientific management practices for the moose population found in Anchorage. A description of the...

  13. Proposed Becharof Wildlife Refuge headquarters site inventory King Salmon and Naknek

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — As d2 legislation moves through Congress, the Refuges and Resource Planning Divisions of the U.S. Fish and Wildlife Service office in Anchorage work to prepare for...

  14. 14 CFR 93.51 - Applicability.

    Science.gov (United States)

    2010-01-01

    ... AND GENERAL OPERATING RULES SPECIAL AIR TRAFFIC RULES Anchorage, Alaska, Terminal Area § 93.51... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Applicability. 93.51 Section 93.51..., Terminal Area....

  15. Eagle river flats bird dieoff: A summary of findings 1988

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Since 1982, periodic waterfowl die-offs have been documented at Ft. Richardson Army Base, Anchorage, Alaska in an area at the mouth of Eagle River known as Eagle...

  16. 50 CFR 217.204 - Mitigation.

    Science.gov (United States)

    2010-10-01

    ... SPECIFIED ACTIVITIES Taking Of Marine Mammals Incidental To The Port of Anchorage Marine Terminal... cease and vessels will reduce to the slowest speed practicable while still maintaining control of...

  17. 50 CFR 29.21-2 - Application procedures.

    Science.gov (United States)

    2010-10-01

    ... “Procedures for the Protection of Historic and Cultural Properties” (36 CFR, part 800). Concerning the... including the impact on air and water quality; scenic and esthetic features; historic, architectural..., 1101 E. Tudor Road, Anchorage, Alaska 99503....

  18. 78 FR 78824 - North Pacific Fishery Management Council; Public Meeting

    Science.gov (United States)

    2013-12-27

    ... Modeling Workshop. SUMMARY: The workshop will be held January 14-17 at the Hilton Hotel, 500 West Third....m. to 5 p.m. ADDRESSES: The workshop will be held at the Anchorage Hilton Hotel, 500 West...

  19. Phellinus linteus suppresses growth, angiogenesis and invasive behaviour of breast cancer cells through the inhibition of AKT signalling

    OpenAIRE

    Sliva, D; Jedinak, A; Kawasaki, J.; Harvey, K; Slivova, V

    2008-01-01

    The antitumour activity of a medicinal mushroom Phellinus linteus (PL), through the stimulation of immune system or the induction of apoptosis, has been recently described. However, the molecular mechanisms responsible for the inhibition of invasive behaviour of cancer cells remain to be addressed. In the present study, we demonstrate that PL inhibits proliferation (anchorage-dependent growth) as well as colony formation (anchorage-independent growth) of highly invasive human breast cancer ce...

  20. Reversible Adaptive Plasticity: A Mechanism for Neuroblastoma Cell Heterogeneity and Chemo-Resistance

    OpenAIRE

    AnthonyDSandler

    2012-01-01

    We describe a novel form of tumor cell plasticity characterized by reversible adaptive plasticity in murine and human neuroblastoma. Two cellular phenotypes were defined by their ability to exhibit adhered, anchorage dependent (AD) or sphere forming, anchorage independent (AI) growth. The tumor cells could transition back and forth between the two phenotypes and the transition was dependent on the culture conditions. Both cell phenotypes exhibited stem-like features such as expression of nest...

  1. Stem Cell Derived Extracellular Matrix Enables Survival and Multi Lineage Differentiation within Superporous Hydrogels

    OpenAIRE

    Köllmer, Melanie; Keskar, Vandana; Hauk, Thomas G.; Collins, John M.; Russell, Brenda; Gemeinhart, Richard A.

    2012-01-01

    Hydrophilic poly(ethylene glycol) diacrylate (PEGDA) hydrogel surfaces resist protein adsorption and are generally thought to be unsuitable for anchorage dependent cells to adhere. Intriguingly, our previous findings revealed that PEGDA superporous hydrogel scaffolds (SPHs) allow anchorage of bone marrow derived human mesenchymal stem cells (hMSCs) and support their long term survival. Therefore, we hypothesized that the physicochemical characteristics of the scaffold impart properties that c...

  2. Application of pre-stressed technology in the crossing construction of the China–Myanmar Gas Pipeline

    Directory of Open Access Journals (Sweden)

    Xuejun Wang

    2015-01-01

    Full Text Available Concrete structure is commonly used in the anchorages of a large cable-suspended pipeline crossing construction. With the increase of span and load, the stress on the concrete anchorages may rise rapidly. In case of traditional anchoring structure fixed by anchor rods, concrete cracking will occur, thereby reducing the anchorage life. To solve this problem, the pre-stressed structure was designed to effectively improve the efficiency of anchoring and reduce engineering cost. In the crossing construction of China–Myanmar Gas Pipeline, the pre-stressed technology was used to establish an effective pre-stressed anchoring system, which integrates the pre-stressed structures (e.g. tunnel anchorages in the anchors and the optimization measures (e.g. positioning mode, anchorage structure, concrete placement, pre-stressed, and medium injection, in line with the crossing structure and load features of this project. The system can delay the occurrence of concrete cracking and enhance the stress durability of the structure and anchoring efficiency. This technology has been successfully applied in the crossing construction of China–Myanmar Gas Pipeline, with good economic and social benefits, indicating that this technology is a new effective solution to the optimization of suspended pipeline anchorage structures, providing technical support for the development of pipeline crossing structure.

  3. A damage detection model for unbonded post-tensioning tendons based on relative strain variation in multi-strand anchors

    Science.gov (United States)

    Abdullah, A. B. M.; Rice, Jennifer A.; Hamilton, H. R.

    2014-03-01

    Post-tensioned segmental bridges are common throughout the US; however, in recent years, the incidence of tendon failure in bonded post-tensioned bridges has raised questions regarding their design, construction, and maintenance. These failures have led to the investigation of the applicability of using replaceable unbonded tendons in segmental construction and new methods for monitoring their condition. This paper presents a damage detection algorithm to identify strand breakage in unbonded tendons based on the relative variation of strains in the anchorage. In unbonded construction, the anchorage assembly usually undergoes a severe stress-state condition as the entire prestressing force only passes through the deviator and end anchorage locations. The strain distribution in the anchorage mechanism, therefore, goes through significant changes in response to the breakage of an individual wire or an entire strand in a multi-strand arrangement. In this way, breakage of a post-tensioning strand can be identified by observing a non-uniform variation of the strain field over the anchorage region in contrast to a uniform variation of strains due to environmental or traffic loading. A reduced scale laboratory experiment is performed followed by an extensive finite element simulation to conduct a parametric study with wire/strand breakages at different locations on multi-strand anchorages commonly used in industry. Based on the observed strain variations from simulation, a damage detection model is proposed that enables the adoption of an automated monitoring strategy to characterize the breakage programmatically.

  4. Analisis parametrico de las variables que influyen en el comportamiento adherente de las armaduras pretesas en el hormigon

    Science.gov (United States)

    Arbelaez Jaramillo, Cesar Augusto

    Prestressed concrete technique through the use of prestressed reinforcement is extended in the precast concrete industry. This technique consists on casting a concrete element over a previously prestressed reinforcement, proceeding to release once the concrete has reached a determined strength so the prestressed stress introduced to the reinforcement be transmitted, by bond, to concrete. The bond behaviour of prestressed reinforcement includes two phenomena: prestress transmission from the reinforcement to concrete and anchorage of the reinforcement. This bond behaviour is characterized by mean of two lengths: transmission length and anchorage length. The good design of these lengths is a basic and fundamental aspect in the project of precast prestressed concrete elements to guaranty the appropriate transmission of prestress and to allow the anchorage of the reinforcement along the structural element service life. The influence of the parameters related to the concrete dosage on the transmission and anchorage lengths of prestressing strands have been analyzed. The ECADA test method has been applied. With this method the operations of transmission of prestress and anchorage of the reinforcement are sequentially done. The transmission and anchorage lengths are determined from the force control supported by the reinforcement testing series of specimens with different embedment lengths. The differentiation of the concepts of anchorage length without slips and with slips has been proposed. The relationship of the parameters of dosage with the bond stress and the registered slips during the processes of transmission and anchorage has been studied. Expressions to value the slips distribution of the reinforcement in the transmission zone and in the anchorage zone have been proposed. A study on the determination of the transmission length from the free reinforcement slip end has been done and the viability to experimentally determine the transmission length from the slips

  5. Pedicle Screw Fixation Study in Immature Porcine Spines to Improve Pullout Resistance during Animal Testing.

    Science.gov (United States)

    Le Cann, Sophie; Cachon, Thibaut; Viguier, Eric; Miladi, Lotfi; Odent, Thierry; Rossi, Jean-Marie; Chabrand, Patrick

    2015-01-01

    The porcine model is frequently used during development and validation of new spinal devices, because of its likeness to the human spine. These spinal devices are frequently composed of pedicle screws with a reputation for stable fixation but which can suffer pullouts during preclinical implantation on young animals, leading to high morbidity. With a view to identifying the best choices to optimize pedicle screw fixation in the porcine model, this study evaluates ex vivo the impact of weight (age) of the animal, the level of the vertebrae (lumbar or thoracic) and the type of screw anchorage (mono- or bi-cortical) on pedicle screw pullouts. Among the 80 pig vertebrae (90- and 140-day-old) tested in this study, the average screw pullout forces ranged between 419.9N and 1341.2N. In addition, statistical differences were found between test groups, pointing out the influence of the three parameters stated above. We found that the the more caudally the screws are positioned (lumbar level), the greater their pullout resistance is, moreover, screw stability increases with the age, and finally, the screws implanted with a mono-cortical anchorage sustained lower pullout forces than those implanted with a bi-cortical anchorage. We conclude that the best anchorage can be obtained with older animals, using a lumbar fixation and long screws traversing the vertebra and inducing bi-cortical anchorage. In very young animals, pedicle screw fixations need to be bi-cortical and more numerous to prevent pullout. PMID:26451947

  6. Pedicle Screw Fixation Study in Immature Porcine Spines to Improve Pullout Resistance during Animal Testing.

    Directory of Open Access Journals (Sweden)

    Sophie Le Cann

    Full Text Available The porcine model is frequently used during development and validation of new spinal devices, because of its likeness to the human spine. These spinal devices are frequently composed of pedicle screws with a reputation for stable fixation but which can suffer pullouts during preclinical implantation on young animals, leading to high morbidity. With a view to identifying the best choices to optimize pedicle screw fixation in the porcine model, this study evaluates ex vivo the impact of weight (age of the animal, the level of the vertebrae (lumbar or thoracic and the type of screw anchorage (mono- or bi-cortical on pedicle screw pullouts. Among the 80 pig vertebrae (90- and 140-day-old tested in this study, the average screw pullout forces ranged between 419.9N and 1341.2N. In addition, statistical differences were found between test groups, pointing out the influence of the three parameters stated above. We found that the the more caudally the screws are positioned (lumbar level, the greater their pullout resistance is, moreover, screw stability increases with the age, and finally, the screws implanted with a mono-cortical anchorage sustained lower pullout forces than those implanted with a bi-cortical anchorage. We conclude that the best anchorage can be obtained with older animals, using a lumbar fixation and long screws traversing the vertebra and inducing bi-cortical anchorage. In very young animals, pedicle screw fixations need to be bi-cortical and more numerous to prevent pullout.

  7. Stone cladding engineering

    CERN Document Server

    Sousa Camposinhos, Rui de

    2014-01-01

    This volume presents new methodologies for the design of dimension stone based on the concepts of structural design while preserving the excellence of stonemasonry practice in façade engineering. Straightforward formulae are provided for computing action on cladding, with special emphasis on the effect of seismic forces, including an extensive general methodology applied to non-structural elements. Based on the Load and Resistance Factor Design Format (LRDF), minimum slab thickness formulae are presented that take into consideration stress concentrations analysis based on the Finite Element Method (FEM) for the most commonly used modern anchorage systems. Calculation examples allow designers to solve several anchorage engineering problems in a detailed and objective manner, underlining the key parameters. The design of the anchorage metal parts, either in stainless steel or aluminum, is also presented.

  8. Computing of the Anchor by the Method of Three-Dimension Point-Radiate Infinite Elements

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    On the basis of the one-dimension infinite element theory, the coordinate translation and shape function of 3D point-radiate 8-node and 4-node infinite elements are derived. They are coupled with 20-node and 8-node finite elements to compute the compression distortion of the prestressed anchorage segment. The results indicate that when the prestressed force acts on the anchorage head and segment, the stresses and the displacements in the rock around the anchorage head and segment concentrate on the zone center with the anchor axis, and they decrease with exponential forms. Therefore,the stresses and the displacement spindles are formed. The calculating results of the infinite element are close to the theoretical results. This indicates the method is right. This article introduces a new way to study the mechanism of prestressed anchors. The obtained results have an important role in the research of the anchor mechanism and engineering application.

  9. Transversely Compressed- and Restrained Shear Joints

    DEFF Research Database (Denmark)

    Schmidt, Jacob Wittrup; Hansen, Christian Skodborg

    2013-01-01

    Anchorage of FRP strengthening systems where the deformation perpendicular to the FRP material is restrained or a compressive force is applied on the strengthening, seems to provide ductility, increased utilization of the FRP and failure modes which can be controlled through the anchorage method....... This paper presents theoretical model which can predict the response of transversely compressed and restrained single- and double lap shear joints. The interface material model is based on a cohesive law in the shear-slip plane with a descending branch and a uniform frictional stress added due to the...... friction in the crack, emanating from the transverse pressure or restraint. The theoretical model is compared with experimental results from transversely compressed single- and double shear joints. Also theoretical predictions of a mechanical integrated sleeve-wedge anchorage load capacity are carried out...

  10. 241-U-701 new compressor building and instrument air piping analyses

    International Nuclear Information System (INIS)

    Building anchorage analysis is performed to qualify the design of the new compressor building foundation given in the ECN ''241-U-701 New Compressor Building.'' Recommendations for some changes in the ECN are made accordingly. Calculations show that the 6-in.-slab is capable of supporting the pipe supports, and that the building foundation, air compressor and dryer anchorage, and electric rack are adequate structurally. Analysis also shows that the instrument air piping and pipe supports for the compressed air system meet the applicable code requirements and are acceptable. The building is for the U-Farm instrument air systems

  11. Calculation of shear strength of prestressed hollow core slabs by use of plastic theory

    DEFF Research Database (Denmark)

    Hoang, Linh Cao; Jørgensen, Henrik Brøner; Nielsen, Mogens Peter

    2014-01-01

    This paper deals with calculations of the shear capacity of precast, prestressed hollow core slabs. Such slabs are often used as floor systems in Building structures. A common way to produce hollow core slabs is to use the extrusion technique where long strips of slabs are extruded and thereafter...... saw-cut into units with the desirable length. For this reason, hollow core slabs are usually not shear reinforced and anchorage of the prestressing strands has to be established by bond. Hollow core slabs may therefore be more critical to shear and Anchorage failure than ordinary two-way spanning...

  12. Calculation of shear strength of prestressed hollow core slabs by use of plastic theory

    DEFF Research Database (Denmark)

    Hoang, Linh Cao; Jørgensen, H.G.; Nielsen, Mogens Peter

    2014-01-01

    Th is paper deals with calculations of the shear capacity of precast, prestressed hollow core slabs. Such slabs are often used as floor systems in building structures. A common way to produce hollow core slabs is to use the extrusion technique where long strips of slabs are extruded and thereafter...... saw-cut into units with the desirable length. For this reason, hollow core slabs are usually not shear reinforced and anchorage of the prestressing strands has to be established by bond. Hollow core slabs may therefore be more critical to shear and anchorage failure than ordinary two-way spanning...

  13. Experimental investigations and seismic analysis for benchmark study of 1000 MW WWER type units (water-cooled and moderated reactor) nuclear power plant Kozloduy. Final report from 1 November 1994 - 31 October 1995

    International Nuclear Information System (INIS)

    This final report summarizes the research carried out and the results obtained presented in previous progress reports. In includes the description of the research carried out, namely, definition of terms and references, criteria, design parameters and methods of analysis; development of 3-dimensional and 2-dimensional mathematical models for diesel generator stations concerning seismic analyses; supports and anchorages analyses and seismic capacity estimation for main components of the cooling system; methodology for verification of component anchorages; conclusions drawn concerning the seismic safety of Kozloduy NPP

  14. MULTIPHASE BLASTING OF THE BRIDGE ACROSS THE DRENICA RIVER

    OpenAIRE

    Branko Božić

    1989-01-01

    The construction of new bridges on the sites of the existing ones require demolition of the old bridge. Due to closeness of newly erected bridge elements the fundations of old bridges are demolished by multiphase blasting process. The blasting of the piers and anchorages of the bridge across 'the Drenica river carrying the Balačevac—Goleš industrial railway was done in four phases. The piers and anchorages of a new bridge and its construction elements have been erected before (the paper is pu...

  15. Shear strengthening of full-scale RC T-beams using textile-reinforced mortar and textile-based anchors

    OpenAIRE

    Tetta, Z.C.; Koutas, L.N.; Bournas, D.A.

    2016-01-01

    This paper presents a study on the effectiveness of TRM jacketing in shear strengthening of full-scale reinforced concrete (RC) T-beams focussing on the behaviour of a novel end-anchorage system comprising textile-based anchors. The parameters examined in this study include: (a) the use of textile-based anchors as end-anchorage system of TRM U-jackets; (b) the number of TRM layers; (c) the textile properties (material, geometry); and (d) the strengthening system, namely textile-reinforced mor...

  16. Corticotomy-assisted retraction: An outcome assessment

    Directory of Open Access Journals (Sweden)

    S Vijayashri Sakthi

    2014-01-01

    Conclusion: The rate of retraction with study group was twice as faster when compared to the control group, accelerating during the first 2 months of retraction. There was better anchorage control with the undecorticated molar segment during the retraction period but was found to increase as time advanced.

  17. Lever-arm and mini-implant system for anterior torque control during retraction in lingual orthodontic treatment.

    Science.gov (United States)

    Hong, Ryoon-Ki; Heo, Jung-Min; Ha, Young-Ki

    2005-01-01

    Anterior torque control during retraction is difficult to achieve with lingual orthodontic treatment. This article describes the use of a lever-arm and mini-implant system as absolute anchorage for controlled retraction of the anterior teeth during lingual orthodontic treatment and evaluates 2 protrusion cases treated with this system. Various clinical situations are discussed and analyzed from a biomechanical standpoint. Mini-implants are needed to control the point of force application in the posterior area and produce en masse retraction with no anchorage loss. When the length of the lever-arm is adjusted to the position of the mini-implant, the desired line of action of the retraction force with respect to the center of resistance of the anterior segment is selected. Controlled retraction of the anterior teeth was achieved with no loss of anchorage. The mini-implant, in conjunction with the lever-arm, is useful not only for absolute anchorage but also for anterior torque control during retraction in lingual orthodontic treatment. PMID:15747828

  18. 14 CFR 93.69 - Special requirements, Lake Campbell and Sixmile Lake Airports.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Special requirements, Lake Campbell and Sixmile Lake Airports. 93.69 Section 93.69 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... Anchorage, Alaska, Terminal Area § 93.69 Special requirements, Lake Campbell and Sixmile Lake Airports....

  19. 49 CFR 214.7 - Definitions.

    Science.gov (United States)

    2010-10-01

    ... struck by a moving train or on-track equipment, or in any case is within four feet of the field side of... with track centers spaced less than 25 feet apart. Anchorage means a secure point of attachment for..., an interlocking, or a controlled point, or a segment of controlled track. Controlled track...

  20. The measurement of un-bonded tendon loads in PCPV and primary containment buildings

    International Nuclear Information System (INIS)

    This paper describes work undertaken as part of a study conducted for the Licensees of all commercial nuclear generating stations in the United Kingdom. The scope included researching the records of prestressing tendon load measurements held by the Licensees which encompassed 18 prestressed concrete pressure vessels (PCPV) for gas cooled reactors and one primary containment for PWR; the historical record contains more than 300 reactor-years of data. The main purpose of the study was to assess the validity of specified calibration and measurement techniques used by the Licensees or their contractors to establish jacking and residual anchorage loads in the post construction period. This included existing lift-off measurement techniques such as feeler gauge insertion and displacement transducer systems allied to graphical analysis of jack load versus displacement to determine the residual anchorage load. The second stage was to assess the designer's assumptions regarding long term creep and relaxation effects in the light of all available load checks since construction to determine whether the original design was adversely affected as a result of the current assessment of tendon load distributions. The paper includes summaries of the results of the assessment of historical load check data, load measurement methods and derived residual anchorage loads. Conclusions are made regarding the validity of design assumptions for anchorage and residual tendon loads and their implications for future load measurements

  1. 33 CFR 110.194a - Mobile Bay, Ala., and Mississippi Sound, Miss.

    Science.gov (United States)

    2010-07-01

    ... Sound, Miss. 110.194a Section 110.194a Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF... Mississippi Sound, Miss. (a) The anchorage grounds. (1) The waters of lower Mobile Bay, near Cedar Point... south by latitude 30°20′00″, and on the west by longitude 88°06′00″. (2) The waters of Mississippi...

  2. 改良腭弓矫治后牙锁节对后牙功能恢复的影响%Influence of promote palatine arch treating buccal teeth lock on occlusion function recovery of buccal teeth

    Institute of Scientific and Technical Information of China (English)

    马宁; 孙应明; 白槐延

    2002-01-01

    @@ Background: Buccal teeth occlusion lock is a kind of common malocclusion malformation in orthodonic clinic. Traditional treatment to buccal teeth occlusion lock is interactive traction of upper and lower buccal teeth.This treatment had shortcoming such as insufficient anchorage and elongation of buccal teeth.We adopted promote fix palatine arch therapy, which recovery patients' occlusion function by clinical observation.

  3. 77 FR 67386 - Announcement of Funding Awards; Indian Community Development Block Grant Program; Fiscal Year 2012

    Science.gov (United States)

    2012-11-09

    ..., Anchorage, AK 99508, (907) 793- 3088. Crow Creek Housing Authority, Joseph 900,000 Housing Rehabilitation.... occupied/3 rental units and Box 38, Pablo, MT 59855, (406) 675-4491. homebuyer assistance. Sault Ste. Marie..., 523 Infrastructure. Ashmun Street, Sault Ste. Marie, MI 49783, (906) 635-6050. Seminole...

  4. Development of Mechanical Anchor for CFRP Tendons Using Integrated Sleeve

    DEFF Research Database (Denmark)

    Schmidt, Jacob Wittrup; Bennitz, Anders; Täljsten, Björn; Pedersen, Henning

    2010-01-01

    A durable and very efficient external strengthening system is achieved if steel tendons for post-tensioning applications can be replaced with CFRP (Carbon Fibre Reinforced Polymer) tendons and if reliable anchorage systems are developed,. This paper presents a newly developed and simple-to-use two...

  5. 50 CFR 679.61 - Formation and operation of fishery cooperatives.

    Science.gov (United States)

    2010-10-01

    ... materials to the North Pacific Fishery Management Council, 605 West 4th Ave, Suite 306, Anchorage, AK 99501... State of Alaska for any pollock harvested in the directed pollock fishery that are not landed in the State of Alaska, in amounts which would otherwise accrue had the pollock been landed in the State...

  6. A concrete balanced cantilever box girder bridge in the Netherlands with carbon fibre prestressing cables

    NARCIS (Netherlands)

    Hordijk, D.A.; Bruggeling, A.S.G.; Kaptijn, N.

    1998-01-01

    In the Netherlands a pilot project has started to recognize the possibilities of non-metallic materials for prestressing. This project will also serve to gather more knowledge regarding the properties of non-metallic wires, their anchorages and their application in large tendons. It is intended to a

  7. 76 FR 55325 - Approval and Promulgation of State Implementation Plans: Alaska

    Science.gov (United States)

    2011-09-07

    ... of Subjects in 40 CFR Part 52 Environmental protection, Air pollution control, Carbon monoxide..., 1978. The Municipality of Anchorage prepared a plan to attain the CO National Ambient Air Quality... (67 FR 58711). \\1\\ The national 8-hour CO ambient standard is attained when the highest 8-hour...

  8. 77 FR 1414 - Approval and Promulgation of State Implementation Plans: Alaska

    Science.gov (United States)

    2012-01-10

    ... Environmental protection, Air pollution control, Carbon monoxide, Incorporation by reference, Intergovernmental... Anchorage Carbon Monoxide Maintenance Plan (Volume II Sections II, III.A and III.B of the State Air Quality... maintenance of the National Ambient Air Quality Standards (NAAQS), or any other CAA requirements. See...

  9. 40 CFR 52.70 - Identification of plan.

    Science.gov (United States)

    2010-07-01

    ... Section V. Ambient Air Monitoring A. Purpose B. Completed Air Monitoring Projects 1. Carbon Monoxide 2... National Ambient Air Quality Standards for carbon monoxide in the Anchorage carbon monoxide nonattainment... Actions, Section III.A. Statewide Carbon Monoxide Control Program, April 4, 2008 (3)......

  10. American Occupation

    Institute of Scientific and Technical Information of China (English)

    CHEN WEN

    2011-01-01

    The "Occupy Wall Street" protests have grown from an insignificant lower Manhattan gathering of around 1,500 people to tens of thousands of people across the United States,from Anchorage,Alaska to Tampa,Florida.The protests started on September 17,denouncing the greed and recklessness of the financial titans who brought down the U.S.economy.

  11. 75 FR 48321 - ORPC Alaska, LLC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting...

    Science.gov (United States)

    2010-08-10

    ... the Cook Inlet ] Tidal Energy Project to be located in Cook Inlet in the vicinity of Anchorage, Alaska... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission ORPC Alaska, LLC; Notice of Preliminary Permit Application Accepted...

  12. 78 FR 44557 - Turnagain Arm Tidal Energy Corporation; Notice of Preliminary Permit Application Accepted for...

    Science.gov (United States)

    2013-07-24

    ... Energy Regulatory Commission Turnagain Arm Tidal Energy Corporation; Notice of Preliminary Permit... February 1, 2013, the Turnagain Arm Tidal Energy Corporation, filed an application for a preliminary permit... Tidal Energy Corporation, 821 N. Street, Suite 207, Anchorage, Alaska 99501; phone: (907) 274-7571....

  13. The life times of polymer composites in construction

    Science.gov (United States)

    Meier, Urs

    2016-05-01

    This paper discusses examples that prove the long-term reliability of Fiber Reinforced Polymers (FRP) under extreme loading conditions and outdoor weathering. Results of polymer/steel-composite anchorage systems, Glass Fiber Reinforced Polymer (GFRP) plates and shells, GFRP box girders, Carbon Fiber Reinforced Polymer (CFRP) post-tensioning tendons and CFRP stays are going to be presented.

  14. 49 CFR 179.102-1 - Carbon dioxide, refrigerated liquid.

    Science.gov (United States)

    2010-10-01

    ....102-1, see the List of CFR Sections Affected, which appears in the Finding Aids section of the printed... and anchorage of tanks must be made of carbon steel conforming to ASTM A 516/A 516M (IBR, see § 171.7...) (IBR, see § 171.7 of this subchapter) in the longitudinal direction of rolling. The TC 128 plate...

  15. Helping General Physical Educators and Adapted Physical Educators Address the Office of Civil Rights Dear Colleague Guidance Letter: Part III--Practitioners and Programs

    Science.gov (United States)

    Poulin, David; Martinez, David; Aenchbacher, Amy; Aiello, Rocco; Doyle, Mike; Hilgenbrinck, Linda; Busse, Sean; Cappuccio, Jim

    2013-01-01

    In Part III of the feature, physical educators and adapted physical educators offer current best practices as models of implementation for readers. Contributions included are: (1) Answer to the Dear Colleague Letter from the Anchorage School District's Adapted Sport Program (David Poulin); (2) Georgia's Adapted Physical Educators…

  16. Strategies for Successful Retention of Alaska Native and American Indian Study Participants

    Science.gov (United States)

    Redwood, Diana; Leston, Jessica; Asay, Elvin; Ferucci, Elizabeth; Etzel, Ruth; Lanier, Anne P.

    2011-01-01

    This paper reports the strategies used to track and follow 3,828 Alaska Native and American Indian study participants in the city of Anchorage and more rural areas of Alaska and provides characteristics of respondents and non-respondents. Over 88% were successfully followed-up, with 49% of respondents completed in three or fewer attempts.…

  17. Report of a Class I bimaxillary dental protrusion case with extraction of first premolars treated with Clarity™ SL MBT appliances

    Directory of Open Access Journals (Sweden)

    Hugo Trevisi

    2013-01-01

    Full Text Available Bimaxillary protrusion cases are common in orthodontic practice. For the best facial outcome, the biomechanics can often be challenging. A class I bimaxillary protrusion case is presented below illustrating the careful application of extractions and bracket prescription. The case highlights how self-ligating brackets and high precision bracket positioning can reduce the need for additional anchorage.

  18. 78 FR 55061 - North Pacific Fishery Management Council; Public Meetings

    Science.gov (United States)

    2013-09-09

    ... the Magnuson- Stevens Act section 302(g)(1)(e), and the National Standard 2 guidelines (78 FR 43066). The peer review process is also deemed to satisfy the requirements of the Information Quality Act... executive sessions. ADDRESSES: The meetings will be held on Hilton Hotel, 500 West 3rd Avenue, Anchorage,...

  19. 76 FR 82114 - Amendment of VOR Federal Airways V-320 and V-440; Alaska

    Science.gov (United States)

    2011-12-30

    ... Anchorage VOR navigation aid (76 FR 68674). Interested parties were invited to participate in this... (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a regulatory evaluation as.... 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The incorporation by reference in...

  20. Surface slick trajectories and risk analysis to oil spill and its derivates, caused by vessel in the Vitoria Bay and Espirito Santo Bay; Analise da trajetoria e dos riscos do derrame de petroleo e seus derivados proveniente da area de fundeio dos portos situados nas baias de Vitoria e do Espirito Santo

    Energy Technology Data Exchange (ETDEWEB)

    Fontana, A.R. [Espirito Santo Univ., Vitoria, ES (Brazil). Programa de Pos-graduacao em Engenharia Ambiental]. E-mail: arfont@terra.com.br; Sarmento, R. [Espirito Santo Univ., Vitoria, ES (Brazil)]. E-mail: robsar@npd.ufes.br

    2003-07-01

    This report presents information of surface slick trajectories and risk analysis to oil spill, provoked by vessel in the Vitoria Bay and Espirito Santo Bay anchorage port area. The trajectory has been simulated by mathematical modeling surface spill trajectory, pushed by wind and tidal currents. Those information are a contribution to elaborate contingency plans to the ports activities in this region. (author)

  1. Un error en los calculos matematicos destroza el acelerador de particulas del CERN

    CERN Multimedia

    Cernuda, Olalla

    2007-01-01

    The most famous particle accelerator in the world, who is at CERN, has suffered a catastrophic damage after a great explosion took place in its depths. This explosion has an absolutely scientific explanation: a mathematical mistake in the design of the anchorages of great magnets. (1 page)

  2. Encoding the Shipping Crisis

    Institute of Scientific and Technical Information of China (English)

    Xue Lina; Lin Lin; Wang Siyuan

    2009-01-01

    @@ According to the statistics from Frech shipping advisory bod-ies,till December 21,2008,165 container ships were idle,leav-ing the fees,such as anchorage fees,ship maintaining fee,crev resettlement fee and repaying loans for ship-buying,an-noying the ship-owners.

  3. 33 CFR 401.83 - Reporting position at anchor, wharf, etc.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Reporting position at anchor, wharf, etc. 401.83 Section 401.83 Navigation and Navigable Waters SAINT LAWRENCE SEAWAY DEVELOPMENT... § 401.83 Reporting position at anchor, wharf, etc. A vessel anchoring in a designated anchorage area,...

  4. The Educational Attainment of Children with Fetal Alcohol Syndrome. Recommendations and Reports.

    Science.gov (United States)

    Gessner, Bradford; Bischoff, Herbert; Perham-Hester, Kathy; Chandler, Bruce; Middaugh, John

    This study examined the educational records of 36 children who met all or most of the criteria for fetal alcohol syndrome (FAS) and who were referred to special education in Anchorage, Fairbanks, or Juneau (Alaska) school districts. Thirty of the children were found to have medical comorbidities independent of the findings generally associated…

  5. Reinforced concrete T-beams externally prestressed with unbonded carbon fiber-reinforced polymer tendons

    DEFF Research Database (Denmark)

    Bennitz, Anders; Nilimaa, Jonny; Ravn, Dorthe Lund;

    2012-01-01

    This study describes a series of experiments examining the behavior of seven beams prestressed with unbonded external carbon fiberreinforced polymer (CFRP) tendons anchored using a newly developed anchorage and post-tensioning system. The effects of varying the initial tendon depth, prestressing ...

  6. Association between different types of chromosomal aberrations in human peripheral lymphocytes and cancer in different locations

    Czech Academy of Sciences Publication Activity Database

    Šmerhovský, Zdeněk; Landa, K.; Rössner st., Pavel; Juzova, D.

    2002-01-01

    Roč. 39, č. 33 (2002), s. 59. ISSN 0893-6692. [ Environmental Mutagen Society Annual Meeting /33./. 27.04.2002-02.05.2002, Anchorage - USA] R&D Projects: GA MZd NJ5177 Grant ostatní: GA-(EC) QLK4-2000-00628 Keywords : cytogenic analysis * cancer incidence * chromosomal aberrations Subject RIV: DN - Health Impact of the Environment Quality

  7. Peri-implant evaluation of osseointegrated implants subjected to orthodontic forces: results after three years of functional loading

    Science.gov (United States)

    Marins, Bruna de Rezende; Pramiu, Suy Ellen; Busato, Mauro Carlos Agner; Marchi, Luiz Carlos; Togashi, Adriane Yaeko

    2016-01-01

    ABSTRACT Objective: The objective of this study was to clinically and radiographically assess the peri-implant conditions of implants used as orthodontic anchorage. Methods: Two groups were studied: 1) a test group in which osseointegrated implants were used as orthodontic anchorage, with the application of 200-cN force; and 2) a control group in which implants were not subjected to orthodontic force, but supported a screw-retained prosthesis. Clinical evaluations were performed three, six and nine months after prosthesis installation and 1- and 3-year follow-up examinations. Intraoral periapical radiographs were obtained 30 days after surgical implant placement, at the time of prosthesis installation, and one, two and three years thereafter. The results were compared by Kruskal-Wallis test. Results: There was no statistically significant difference in clinical probing depth (p = 0.1078) or mesial and distal crestal bone resorption (p = 0.1832) during the study period. After three years of follow-up, the mean probing depth was 2.21 mm for the control group and 2.39 mm for the test group. The implants of the control group showed a mean distance between the bone crest and implant shoulder of 2.39 mm, whereas the implants used as orthodontic anchorage showed a mean distance of 2.58 mm at the distal site. Conclusion: Results suggest that the use of stable intraoral orthodontic anchorage did not compromise the health of peri-implant tissues or the longevity of the implant. PMID:27275618

  8. 33 CFR 110.140 - Buzzards Bay, Nantucket Sound, and adjacent waters, Mass.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Buzzards Bay, Nantucket Sound, and adjacent waters, Mass. 110.140 Section 110.140 Navigation and Navigable Waters COAST GUARD..., Nantucket Sound, and adjacent waters, Mass. (a) New Bedford Outer Harbor—(1) Anchorage A. West of...

  9. 14 CFR 93.59 - General rules: International segment.

    Science.gov (United States)

    2010-01-01

    ... (CONTINUED) AIR TRAFFIC AND GENERAL OPERATING RULES SPECIAL AIR TRAFFIC RULES Anchorage, Alaska, Terminal... Knik Arm. (b) Each person operating an airplane at a speed of more than 105 knots within this segment... person operating an airplane at a speed of 105 knots or less within this segment (except that...

  10. 14 CFR 93.63 - General rules: Merrill segment.

    Science.gov (United States)

    2010-01-01

    ... (CONTINUED) AIR TRAFFIC AND GENERAL OPERATING RULES SPECIAL AIR TRAFFIC RULES Anchorage, Alaska, Terminal... Knik Arm. (b) Each person operating an airplane at a speed of more than 105 knots within this segment... person operating an airplane at a speed of 105 knots or less within this segment (except for that...

  11. 14 CFR 93.65 - General rules: Elmendorf segment.

    Science.gov (United States)

    2010-01-01

    ... (CONTINUED) AIR TRAFFIC AND GENERAL OPERATING RULES SPECIAL AIR TRAFFIC RULES Anchorage, Alaska, Terminal... turbine-powered aircraft) at a speed of more than 105 knots within this segment shall operate that... descent. (c) Each person operating an airplane (other than turbine-powered aircraft) at a speed of...

  12. 78 FR 12794 - Notice of Determinations Regarding Eligibility To Apply for Worker Adjustment Assistance

    Science.gov (United States)

    2013-02-25

    .... Corporation (IBC), Hostess Brands, Inc. 82,165A Interstate Brands Montgomery, AL..... November 19, 2011. Corporation (IBC), Hostess Brands, Inc. 82,165AA Interstate Brands Rochester, NH...... November 19, 2011. Corporation (IBC), Hostess Brands, Inc. 82,165B Interstate Brands Anchorage, AK...... November 19,...

  13. A simple approach to cancer therapy afforded by multivalent pseudopeptides that target cell-surface nucleoproteins

    NARCIS (Netherlands)

    Destouches, D.; Page, N.; Hamma-Kourbali, Y.; Machi, V.; Chaloin, O.; Frechault, S.; Birmpas, C.; Katsoris, P.; Beyrath, J.D.; Albanese, P.; Maurer, M.; Carpentier, G.; Strub, J.M.; Dorsselaer, A. van; Muller, S.; Bagnard, D.; Briand, J.P.; Courty, J.

    2011-01-01

    Recent studies have implicated the involvement of cell surface forms of nucleolin in tumor growth. In this study, we investigated whether a synthetic ligand of cell-surface nucleolin known as N6L could exert antitumor activity. We found that N6L inhibits the anchorage-dependent and independent growt

  14. Gonorrhea among drug users: an Alaskan versus a national sample.

    Science.gov (United States)

    Paschane, D M; Fisher, D G; Cagle, H H; Fenaughty, A M

    1998-05-01

    The study described here investigates the replicability of gender-specific risk profiles for gonorrhea based on an Alaskan sample compared to a U.S. national sample of drug users at risk for HIV infection. The Alaska sample (interviewed at a field station in Anchorage, Alaska; N=1,049) and the national sample (interviewed at 18 sites other than Alaska; N=17,619) consisted of cocaine smokers and injection drug users not in drug treatment. A history of gonorrhea infection was self-reported and coded as ever or never. The Anchorage and national risk profile for men included the following factors: (a) history of intranasal or parenteral cocaine use, (b) being black versus nonblack, (c) being older, (d) income from illegal activity, and (e) history of amphetamine use. The Anchorage and national risk profiles for women included the following factors: (a) trading sex for money, (b) being Native American versus non-Native American, and (c) trading sex for drugs. The Anchorage model for women included perceived homelessness as a factor, but it was not retained in the national model. The extent of the replicability of these models illustrates the generalizability of Alaskan findings to other U.S. drug-using populations. The authors also discuss the implications of these findings for disease prevention. PMID:9643466

  15. Economic Education Experiences of Award Winning Alaska Teachers.

    Science.gov (United States)

    Thomas, Monica, Ed.

    Award-winning economic education projects devised by Alaska teachers included three elementary (K-6) projects and three second level (7-12) ones. Faith Greenough's students (Chinook Elementary School, Anchorage) compared Tlingit traditional and market economies in Alaska, so economics became an integrated part of elementary instruction. Marie…

  16. Seismic Adequacy Review of PC012 SCEs that are Potential Seismic Hazards with PC3 SCEs - CVD Facility

    International Nuclear Information System (INIS)

    This document provides seismic adequacy review of PCO12 Systems, Components L Equipment anchorage that are potential seismic interaction hazards with PC3 SCEs during a Design Basis Earthquake. The PCO12 items are identified in the Safety Equipment List as 3/1 SCEs

  17. 76 FR 14883 - Endangered and Threatened Species; Proposed Threatened Status for Distinct Population Segments of...

    Science.gov (United States)

    2011-03-18

    ...) 713- 1401. SUPPLEMENTARY INFORMATION: Background On December 10, 2010 (75 FR 77496), we published a... to March 25, 2011 (76 FR 6755; February 8, 2011). Public Hearings Joint Commerce--Interior ESA... public hearings to be held in Anchorage and Barrow, AK (76 FR 9734, February 22, 2011). We are...

  18. 50 CFR 27.92 - Private structures.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Private structures. 27.92 Section 27.92... NATIONAL WILDLIFE REFUGE SYSTEM PROHIBITED ACTS Other Disturbing Violations § 27.92 Private structures. No..., pier, dock, fence, wall, pile, anchorage, or other structure or obstruction in any national...

  19. Using Personnel Evaluation To Focus on the Development of Teaching Skills: Faculty Ideas and University Policy.

    Science.gov (United States)

    O'Leary, Neil; Fenton, Ray

    The role of the personnel evaluation process in improving the performance of teachers as classroom communicators is explored by contrasting the personnel evaluation system of Alaska Pacific University (APU) with that of the Anchorage School District (Alaska). While the APU system offers little specification for formative evaluation activities, the…

  20. 29 CFR 1926.601 - Motor vehicles.

    Science.gov (United States)

    2010-07-01

    ... employees to be carried. (9) Seat belts and anchorages meeting the requirements of 49 CFR part 571... 29 Labor 8 2010-07-01 2010-07-01 false Motor vehicles. 1926.601 Section 1926.601 Labor Regulations...) SAFETY AND HEALTH REGULATIONS FOR CONSTRUCTION Motor Vehicles, Mechanized Equipment, and...

  1. Early loading of plalatal implants (ortho-type II a prospective multicenter randomized controlled clinical trial

    Directory of Open Access Journals (Sweden)

    Gedrange Tomasz

    2007-09-01

    Full Text Available Abstract Background In orthodontic treatment, anchorage control is a fundamental aspect. Usually conventional mechanism for orthodontic anchorage control can be either extraoral or intraoral that is headgear or intermaxillary elastics. Their use are combined with various side effects such as tipping of occlusal plane or undesirable movements of teeth. Especially in cases, where key-teeth are missing, conventional anchorage defined as tooth-borne anchorage will meet limitations. Therefore, the use of endosseous implants for anchorage purposes are increasingly used to achieve positional stability and maximum anchorage. Methods/Design The intended study is designed as a prospective, multicenter randomized controlled trial (RCT, comparing and contrasting the effect of early loading of palatal implant therapy versus implant loading after 12 weeks post implantation using the new ortho-implant type II anchor system device (Orthosystem Straumann, Basel, Switzerland. 124 participants, mainly adult males or females, whose diagnoses require temporary stationary implant-based anchorage treatment will be randomized 1:1 to one of two treatment groups: group 1 will receive a loading of implant standard therapy after a healing period of 12 week (gold standard, whereas group 2 will receive an early loading of orthodontic implants within 1 week after implant insertion. Participants will be at least followed for 12 months after implant placement. The primary endpoint is to investigate the behavior of early loaded palatal implants in order to find out if shorter healing periods might be justified to accelerate active orthodontic treatment. Secondary outcomes will focus e.g. on achievement of orthodontic treatment goals and quantity of direct implant-bone interface of removed bone specimens. As tertiary objective, a histologic and microtomography evaluation of all retrieved implants will be performed to obtain data on the performance of the SLA surface in human bone

  2. PtdIns(3,4,5)P3-dependent Rac Exchanger 1 (PREX1) Rac-Guanine Nucleotide Exchange Factor (GEF) Activity Promotes Breast Cancer Cell Proliferation and Tumor Growth via Activation of Extracellular Signal-regulated Kinase 1/2 (ERK1/2) Signaling.

    Science.gov (United States)

    Liu, Heng-Jia; Ooms, Lisa M; Srijakotre, Nuthasuda; Man, Joey; Vieusseux, Jessica; Waters, JoAnne E; Feng, Yue; Bailey, Charles G; Rasko, John E J; Price, John T; Mitchell, Christina A

    2016-08-12

    PtdIns(3,4,5)P3-dependent Rac exchanger 1 (PREX1) is a Rac-guanine nucleotide exchange factor (GEF) overexpressed in a significant proportion of human breast cancers that integrates signals from upstream ErbB2/3 and CXCR4 membrane surface receptors. However, the PREX1 domains that facilitate its oncogenic activity and downstream signaling are not completely understood. We identify that ERK1/2 MAPK acts downstream of PREX1 and contributes to PREX1-mediated anchorage-independent cell growth. PREX1 overexpression increased but its shRNA knockdown decreased ERK1/2 phosphorylation in response to EGF/IGF-1 stimulation, resulting in induction of the cell cycle regulators cyclin D1 and p21(WAF1/CIP1) PREX1-mediated ERK1/2 phosphorylation, anchorage-independent cell growth, and cell migration were suppressed by inhibition of MEK1/2/ERK1/2 signaling. PREX1 overexpression reduced staurosporine-induced apoptosis whereas its shRNA knockdown promoted apoptosis in response to staurosporine or the anti-estrogen drug tamoxifen. Expression of wild-type but not GEF-inactive PREX1 increased anchorage-independent cell growth. In addition, mouse xenograft studies revealed that expression of wild-type but not GEF-dead PREX1 resulted in the formation of larger tumors that displayed increased phosphorylation of ERK1/2 but not AKT. The impaired anchorage-independent cell growth, apoptosis, and ERK1/2 signaling observed in stable PREX1 knockdown cells was restored by expression of wild-type but not GEF-dead-PREX1. Therefore, PREX1-Rac-GEF activity is critical for PREX1-dependent anchorage-independent cell growth and xenograft tumor growth and may represent a possible therapeutic target for breast cancers that exhibit PREX1 overexpression. PMID:27358402

  3. Prestressing in nuclear power plants anchor lift-off measuring system for 37 T 15 tendons

    International Nuclear Information System (INIS)

    The Asco Nuclear Power Plant is composed of two 930 MW PWR units. The external wall of the Containment Building in each unit is made of prestressed concrete. The Pre-stressing System, a Freyssinet technology using 37 T 15 tendons, is of the non-adhering type (sheathing is filled with grease). This technique allows to verify the design conditions of the prestressing design directly through the tendons by means of periodical inspections carried out during the whole life of the structure. These inspections take place three times in the first five years and afterwards, once every five years. One of the objectives of these inspections is to measure the prestressing force that the type 37 T 15 tendons apply on the structure. The measurement of the force is made by the same KC 1000 jack used in the pre-tensioning with a capacity of 1000 ton which acts on the tendon anchorage, increasing the outside tendon tension progressively up to reaching the block anchorage lift-off from its support plate. The lift-off force applied by the jack is the internal tension developed by the tendon. The problem is to determine the exact moment when the tendon anchorage block 'lift-off' takes place. In the 1980's decade, the anchorage block lift-off was determined by inserting thin shims. The insertion of one of these shims between the support plate and the anchorage block indicated the separation. Simultaneously, the necessary force applied by the jack to overcome the tendon compressive action on the structure was registered. This force, extrapolated to a zero separation, was assumed to be acting on the anchorage. This procedure had the inconvenient of a lack of accuracy in determining the physical phenomena. The system used at the present to measure the lift-off force consists basically in taking continuous elongation and jacking force data by means of a computerized system. The present work describes this new system, resulting from 15 years of experience in measuring the lift-off forces in

  4. Correction of facial asymmetry and maxillary canting with corticotomy and 1-jaw orthognathic surgery.

    Science.gov (United States)

    Ahn, Hyo-Won; Seo, Dong Hwi; Kim, Seong-Hun; Lee, Baek-Soo; Chung, Kyu-Rhim; Nelson, Gerald

    2014-12-01

    Although 2-jaw orthognathic surgery is a typical recommendation for the treatment of facial asymmetry, another good treatment alternative is maxillary corticotomy with temporary skeletal anchorage devices followed by mandibular orthognathic surgery. The corticotomy procedure described here can achieve unilateral molar intrusion and occlusal plane canting correction with potentially fewer complications than 2-jaw orthognathic surgery. The approach allows movement of dentoalveolar segments in less time than with conventional dental intrusion using temporary skeletal anchorage devices. A 2-jaw asymmetry with occlusal plane canting might be corrected using maxillary corticotomy and mandibular orthognathics rather than 2-jaw orthognathics. Two patients with facial asymmetry are presented here. In each one, the maxillary cant was corrected over a period of 2 to 3 months with 3.5 mm of intrusion of the unilateral buccal segment. After the preorthognathic cant correction, orthognathic surgery was done to correct the mandibular asymmetry. PMID:25432261

  5. Anterior maxillary intrusion and retraction with corticotomy-facilitated orthodontic treatment and burstone three piece intrusive arch.

    Science.gov (United States)

    Prabhakar, Ramachandra; Karthikeyan, M K; Saravanan, R; Kannan, K S; Arun Raj, M R

    2013-12-01

    An adult patient with proclination and spacing was performed orthodontic treatment combined with corticotomy and the burstone three piece intrusive arch who desired a shortened treatment period. The patient had Angle's Class I malocclusion with flaring of the maxillary and mandibular incisors. Pre adjusted edgewise appliance (MBT prescription) was fixed to the maxillary and mandibular teeth. Then corticotomy was performed on the cortical bone of the buccal sides in the maxillary anterior regions. Intrusion and retraction initiated immediately after the corticotomy. The intrusive arch was adjusted once in every 2 weeks. The total treatment time for intrusion was 5 months. Cephalometric superimpositions showed no anchorage loss, and panoramic radiographs showed neither significant reduction in the crestal bone height nor marked apical root resorption. A corticotomy-facilitated orthodontic treatment shortened treatment period without any anchorage loss or adverse effects. PMID:24551742

  6. Epidermal growth factor receptor (EGFR) antisense transfection reduces the expression of EGFR and suppresses the malignant phenotype of a human ovarian cancer cell line.

    Science.gov (United States)

    Brader, K R; Wolf, J K; Chakrabarty, S; Price, J E

    1998-01-01

    An EGFR-expressing clone of the human ovarian cancer line 2774 was transfected with an antisense construct of EGFR to test how suppression of this gene modulates the malignant phenotype. Transfected clones were screened for EGFR expression by Western blot and FACS analysis. Anchorage-independent growth was used to assess the effect of reduced EGFR on the malignant behavior of the cells. Several transfected clones with decreased EGFR (40-50% reduction) were identified. A correlation was noted between reduced EGFR and decreased anchorage-independent growth, with the transfected clones losing the ability to grow in agarose and responsiveness to exogenous EGF. These results suggest that EGFR may be an important factor in the malignant behavior of this ovarian cancer cell line. PMID:9683849

  7. Deflection analysis of reinforced concrete beams strengthened with carbon fibre reinforced polymer under long-term load action

    Institute of Scientific and Technical Information of China (English)

    Mykolas DAUGEVI(C)IUS; Juozas VALIVONIS; Gediminas MAR(C)IUKAITIS

    2012-01-01

    This paper presents the results of an experimental research on reinforced concrete beams strengthened with an external carbon fibre reinforced polymer (CFRP) layer under long-term load action that lasted for 330 d.We describe the characteristics of deflection development of the beams strengthened with different additional anchorages of the external carbon fibre composite layer during the period of interest.The conducted experiments showed that the additional anchorage influences the slip of the extemal layer with respect to the strengthened element.Thus,concrete and carbon fibre composite interface stiffness decreases with a long-term load action.Therefore,the proposed method of analysis based on the built-up-bars theory can be used to estimate concrete and carbon fibre composite interface stiffness in the case of long-term load.

  8. Mitosis and microtubule organizational changes in rice root-tip cells

    Institute of Scientific and Technical Information of China (English)

    XUSHIXIONG(SYZEE); CHUNGUILI; CHENGZHU

    1993-01-01

    The pattern of change of the microtubule cytoskeleton of the root-tip cells of rice during mitosis was studied using immunofluorescence technic and confocal laser scanning microscopy. All the major stages of ceil division including preprophase, prophase, metaphase, anaphase and telophase were observed. The most significant finding was that in the preprophase cells microtubules radiating from the nuclear surface to the cortex were frequently seen. During development these microtubules became closely associated with the preprophase band and prophase spindie indicating that the microtubules radiating from the nuclear surface, the preprophase band and the prophazc spindle were structurally and functionally closely related to each other. Granule-like anchorage sites for the radiating microtubules at the muclear surface were often seen and the possibility that these gramle-like anchorage sites might represent the microtubule organizing centres was discussed.

  9. Plate anchored stirrup; Pureto teichakugata sendan hokyo tekkin

    Energy Technology Data Exchange (ETDEWEB)

    Nakamura, T.; Tanaka, Y.; Nakano, K.; Yamamoto, T. [Taisei Construction Co. Ltd., Tokyo (Japan)

    1998-09-01

    After the Great Hanshin Earthquake, the use of edge form of stirrups of semicircular hook or acute-angled hook which functions sufficiently even after exfoliation of concrete cover is proposed instead of right angle hook. However, when these stirrups are used in plate structures requiring hooks on two ends or in columns as connection reinforcement of hoop, the construction of these stirrups is so complicated that brings higher cost. The authors proposes stirrups to anchor by plate for stirrups of planar members. Anchorage capacity of these plate anchored stirrups and hooks after exfoliation of concrete cover was examined by experiments and the anchorage capacity was confirmed to be larger than that of semicircular hooks. The plate anchored stirrups are effective and easy to construct with low cost. 7 refs., 13 figs., 4 tabs.

  10. Microstructural investigation of innovative UHPC

    Energy Technology Data Exchange (ETDEWEB)

    Reda, M.M.; Shrive, N.G.; Gillott, J.E. [Univ. of Calgary, Alberta (Canada). Dept. of Civil Engineering

    1999-03-01

    The production of ultra high performance concrete (UHPC) with target strengths greater than 200 MPa has recently been considered for specific structural applications that need this enhanced mechanical performance. The main purpose of developing these innovative UHPC mixtures is to produce high-strength precast concrete elements with excellent durability to serve as both the inner wedges and the outer barrel of a new nonmetallic anchorage system. The anchorage is for post-tensioning applications using carbon fiber-reinforced polymer tendons. The UHPC mixtures examined show very dense microstructures with some unique characteristics. The bond between the micro carbon fibers and the cement paste seems to be very good and the cement paste observed in the vicinity of the fibers was shown to be very dense and homogeneous. The micro carbon fibers seem to govern the strength and postcracking behavior of these materials.

  11. Histomorphometric and removal torque analysis for TiO2-blasted titanium implants. An experimental study on dogs

    DEFF Research Database (Denmark)

    Gotfredsen, K; Nimb, L; Hjörting-Hansen, E;

    1992-01-01

    bilaterally and 24 commercial pure titanium implants were placed immediately in extraction sockets and covered with mucoperiosteum. Each dog had inserted 4 implants: 1 screw implant and 1 cylindrical implant blasted with titanium-dioxide-particles; 1 screw implant and 1 cylindrical implant with machine......-produced (m.p.) surface (controls). After a healing period of 12 weeks, 16 implants from 4 animals were used for removal torque test, which demonstrated that significantly higher removal torque force was needed to unscrew the implants blasted with titanium-dioxide-particles, than the normal m.p. implants. The......-blasted implants and the control implants. The implants blasted with titanium-dioxide-particles in this study showed a better anchorage than implants with a machine-produced surface. The screw implants showed a better anchorage than the cylindrical implants....

  12. Strengthening of non-seismically detailed reinforced concrete beam–column joints using SIFCON blocks

    Indian Academy of Sciences (India)

    I S Misir; S Kahraman

    2013-02-01

    This article aims to propose a novel seismic strengthening technique for non-seismically detailed beam–column joints of existing reinforced concrete buildings, typical of the pre-1975 construction practice in Turkey. The technique is based on mounting pre-fabricated SIFCON composite corner and plate blocks on joints with anchorage rods. For the experimental part three 2/3 scale exterior beam–column joint specimens were tested under quasi-static cyclic loading. One of them was a control specimen with non-seismic details, and the remaining two with the same design properties were strengthened with composite blocks with different thickness and anchorage details. Results showed that the control specimen showed brittle shear failure at low drift levels, whereas in the strengthened specimens, plastic hinge formation moved away from column face allowing specimens to fail in flexure. The proposed technique greatly improved lateral strength, stiffness, energy dissipation, and ductility.

  13. Torque control during lingual anterior retraction without posterior appliances

    OpenAIRE

    Mo, Sung-Seo; Kim, Seong-Hun; Sung, Sang-Jin; Chung, Kyu-Rhim; Chun, Yun-Sic; Kook, Yoon-Ah; Nelson, Gerald

    2013-01-01

    Objective To evaluate the factors that affect torque control during anterior retraction when utilizing the C-retractor with a palatal miniplate as an exclusive source of anchorage without posterior appliances. Methods The C-retractor was modeled using a 3-dimensional beam element (0.9-mm-diameter stainless-steel wire) attached to mesh bonding pads. Various vertical heights and 2 attachment positions for the lingual anterior retraction hooks (LARHs) were evaluated. A force of 200 g was applied...

  14. Mandibular lip bumper for molar torque control.

    Science.gov (United States)

    Celentano, Giuseppe; Longobardi, Annalisa; Cannavale, Rosangela; Perillo, Letizia

    2011-01-01

    Treatment effects of lip bumpers alone include flaring of the mandibular incisors, distalization and uprighting of the mandibular first molars, and buccal expansion of the canines, premolars, and molar. Lip forces are transmitted through this appliance onto the molars. Moreover the lip bumper is able to derotate, expand or constrict, upright and reinforce the anchorage whereas torque control is lacking. Aim of this paper is the presentation of a new type of lip bumper that allows the molar torque control. PMID:21515237

  15. New vertical cryostat for the high field superconducting magnet test station at CERN

    Czech Academy of Sciences Publication Activity Database

    Vande Craen, A.; Atieh, S.; Bajko, M.; Benda, M.; de Rijk, G.; Favre, G.; Giloux, C.; Hanzelka, Pavel; Minginette, P.; Parma, V.; Perret, P.; Pirotte, O.; Ramos, D.; Viret, P.

    Melville, New York: American Institute of Physics, 2014, s. 229-236. (AIP Conference Proceedings. 1573). ISBN 978-0-7354-1201-9. ISSN 0094-243X. [Transaction of the Cryogenic Engineering Conference - CEC. Anchorage, Alaska (US), 17.06.2013-21.06.2013] R&D Projects: GA MŠk(CZ) LO1212; GA MŠk ED0017/01/01 Institutional support: RVO:68081731 Keywords : vertical cryostat * FRESCA2 * eucard * high field magnet Subject RIV: BK - Fluid Dynamics

  16. Cellular prion protein contributes to LS 174T colon cancer cell carcinogenesis by increasing invasiveness and resistance against doxorubicin-induced apoptosis.

    Science.gov (United States)

    Chieng, Cornelius Kwang-Lee; Say, Yee-How

    2015-09-01

    As the cellular prion protein (PrP(C)) has been implicated in carcinogenesis, we aimed to investigate the effects of cancer cell-specific PrP(C) overexpression from the invasion, metastasis, and apoptosis aspects, by performing cell motility assays, cell proliferation assays under anchorage-dependent and anchorage-independent conditions, and apoptosis evasion when subjected to multiple anti-cancer drugs. Overexpression of PrP(C) in LS 174T was achieved by stable transfection. PrP(C) overexpression was shown to increase cell proliferation in anchorage-dependent and anchorage-independent manners, as shown by more viable cells in 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, more colonies formed in soft agar assay and increased resistance to anoikis in poly-2-hydroxyethyl methacrylate-coated surface. PrP(C) overexpression also increased cell motility and invasiveness of LS 174T. Cell adhesion to extracellular matrix using collagen- and fibronectin-coated surfaces revealed increased cell attachment in LS 174T cells overexpressing PrP(C). Analysis of apoptotic and necrotic cells by propidium iodide/annexin V-fluorescein isothiocyanate microscopy and 7-amino-actinomycin D/annexin V-phycoerythrin flow cytometry revealed that PrP(C) overexpression attenuated doxorubicin-induced apoptosis. Human apoptosis antibody array with 35 apoptosis-related proteins revealed that three inhibitor of apoptosis proteins (IAPs)-survivin, X-linked inhibitor of apoptosis protein (XIAP), and cellular inhibitor of apoptosis protein-1 (cIAP-1)-were upregulated in LS 174T cells overexpressing PrP(C) in doxorubicin-induced apoptosis. In conclusion, the overexpression of PrP(C) could enhance the invasiveness and survival of LS 174T colorectal cancer cells, indicating that PrP(C) plays a role in colorectal cancer biology. PMID:25983001

  17. HPV vaccines for circumpolar health: summary of plenary session, “Opportunities for Prevention: Global HPV Vaccine” and “Human Papillomavirus Prevention: The Nordic Experience”

    Directory of Open Access Journals (Sweden)

    Eileen F. Dunne

    2013-08-01

    Full Text Available In this publication, we provide an overview of the presentations, “Opportunities for Prevention: Global HPV Vaccine” and “Human Papillomavirus Prevention: The Nordic Experience” as a part of the 15th International Congress on Circumpolar Health, held at Anchorage, Alaska, on August 8, 2012. We provide an overview of HPV, HPV vaccines and policy as well as the Nordic experience with HPV vaccine introduction.

  18. Does surface anodisation of titanium implants change osseointegration and make their extraction from bone any easier?

    OpenAIRE

    Langhoff, J; Mayer, J.; Faber, L.; Kästner, S B; Guibert, G.; Zlinszky, K; Auer, J. A.; von Rechenberg, B

    2008-01-01

    Objectives: Titanium implants have a tendency for high bone-implant bonding, and, in comparison to stainless steel implants are more difficult to remove. The current study was carried out to evaluate, i) the release strength of three selected anodized titanium surfaces with increased nanohardness and low roughness, and ii) bone-implant bonding in vivo. These modified surfaces were intended to give improved anchorage while facilitating easier removal of temporary implants. Material and methods...

  19. Improved extraction torque of hydroxyapatite-coated pedicle screws

    OpenAIRE

    Sandén, B.; Olerud, Claes; JOHANSSON, CARINA; Larsson, Sune

    2000-01-01

    Loosening of the screws is a problem in instrumentation with pedicle screws. Coating with hydroxyapatite improves the holding characteristics for metal implants, but the possible effects on the anchorage of pedicle screws have not been described. In this study, seven patients were operated on with spinal instrumentation using four stainless steel pedicle screws. Hydroxyapatite-coated screws were used in either the upper or the lower of the instrumented levels. The insertion torque was measure...

  20. Mechanical Quantification of Local Bone Quality in the Humeral Head: A Feasibility Study

    OpenAIRE

    Scola, Alexander; Gebhard, Florian; Weckbach, Sebastian; Dehner, Christoph; Schwyn, Ronald; Fliri, Ladina; Röderer, Götz

    2013-01-01

    Objectives: Surgical treatment of proximal humerus fractures can be challenging due to osteoporosis. The weak bone stock makes stable implant anchorage difficult, which can result in low primary stability. Accordingly, significant failure rates, even with modern locking plates, are reported in the literature. Intraoperative knowledge of local bone quality could be helpful in improving results. This study evaluates the feasibility of local bone quality quantification using breakaway torque mea...

  1. Dental implants inserted in native bone: Cases series analyses

    OpenAIRE

    Riccardo Guidi; Alessandro Viscioni; Frencesco Dattola; Francesco Carinci

    2012-01-01

    Background: The concept of osseointegration, i.e., the direct anchorage of endosseous implants made of commercially pure or titanium alloy to the bone caused a breakthrough in oral rehabilitation. The identification of factors for long-term survival and success rate are the main goal of the recent literature. Several variables can influence the final result, and in general they are grouped in surgery-, host-, implant-, and occlusion-related factors. Materials and Methods: A retrospective a...

  2. NIH 3T3 cells stably transfected with the gene encoding phosphatidylcholine-hydrolyzing phospholipase C from Bacillus cereus acquire a transformed phenotype.

    OpenAIRE

    Johansen, T.; Bjørkøy, G; Overvatn, A; Diaz-Meco, M T; Traavik, T; Moscat, J

    1994-01-01

    In order to determine whether chronic elevation of intracellular diacylglycerol levels generated by hydrolysis of phosphatidylcholine (PC) by PC-hydrolyzing phospholipase C (PC-PLC) is oncogenic, we generated stable transfectants of NIH 3T3 cells expressing the gene encoding PC-PLC from Bacillus cereus. We found that constitutive expression of this gene (plc) led to transformation of NIH 3T3 cells as evidenced by anchorage-independent growth in soft agar, formation of transformed foci in tiss...

  3. Comparison between Conventional Mechanical Fixation and Use of Autologous Platelet Rich Plasma (PRP) in Wound Beds Prior to Resurfacing with Split Thickness Skin Graft

    OpenAIRE

    P Waiker, Veena; Shivalingappa, Shanthakumar

    2015-01-01

    BACKGROUND Platelet rich plasma is known for its hemostatic, adhesive and healing properties in view of the multiple growth factors released from the platelets to the site of wound. The primary objective of this study was to use autologous platelet rich plasma (PRP) in wound beds for anchorage of skin grafts instead of conventional methods like sutures, staplers or glue. METHODS In a single center based randomized controlled prospective study of nine months duration, 200 patients with wounds ...

  4. Assessment of potential anti-cancer stem cell activity of marine algal compounds using an in vitro mammosphere assay

    OpenAIRE

    de la Mare, Jo-Anne; Sterrenberg, Jason N; Sukhthankar, Mugdha G; Chiwakata, Maynard T; Denzil R. Beukes; Blatch, Gregory L.; Edkins, Adrienne L.

    2013-01-01

    Background The cancer stem cell (CSC) theory proposes that tumours arise from and are sustained by a subpopulation of cells with both cancer and stem cell properties. One of the key hallmarks of CSCs is the ability to grow anchorage-independently under serum-free culture conditions resulting in the formation of tumourspheres. It has further been reported that these cells are resistant to traditional chemotherapeutic agents. Methods In this study, the tumoursphere assay was validated in MCF-7 ...

  5. Evolution of membrane oxygenator technology for utilization during pediatric cardiopulmonary bypass

    OpenAIRE

    Melchior, Richard

    2016-01-01

    Richard W Melchior,1 Steven W Sutton,2 William Harris,3 Heidi J Dalton4,5 1Department of Perfusion Services, The Children's Hospital of Philadelphia, Philadelphia, PA, 2Cardiovascular Support Services, Inc., Dallas, TX, 3Department of Perfusion Services, Ochsner Clinic Foundation, New Orleans, LA, 4Alaskan Native Tribal Health Consortium, Anchorage, AK, 5Department of Child Health, University of Arizona-College of Medicine, Phoenix, AZ, USAAbstract: The development of the membrane oxy...

  6. Evaluation of near-field earthquake effects

    Energy Technology Data Exchange (ETDEWEB)

    Shrivastava, H.P.

    1994-11-01

    Structures and equipment, which are qualified for the design basis earthquake (DBE) and have anchorage designed for the DBE loading, do not require an evaluation of the near-field earthquake (NFE) effects. However, safety class 1 acceleration sensitive equipment such as electrical relays must be evaluated for both NFE and DBE since they are known to malfunction when excited by high frequency seismic motions.

  7. Inhibition of testicular embryonal carcinoma cell tumorigenicity by peroxisome proliferator-activated receptor-β/δ- and retinoic acid receptor-dependent mechanisms

    OpenAIRE

    Yao, Pei-Li; Chen, Li Ping; Dobrzański, Tomasz P.; Phillips, Dylan A.; Zhu, Bokai; Kang, Boo-Hyon; Frank J. Gonzalez; Peters, Jeffrey M.

    2015-01-01

    Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) has important physiological functions in control of cell growth, lipid and glucose homeostasis, differentiation and inflammation. To investigate the role of PPARβ/δ in cancer, stable human testicular embryonal carcinoma cell lines were developed that constitutively express PPARβ/δ. Expression of PPARβ/δ caused enhanced activation of the receptor, and this significantly decreased proliferation, migration, invasion, anchorage-independent ...

  8. Numerical simulation of galvanized rebars pullout

    OpenAIRE

    Hélder Pereira; Cunha, Vitor M. C. F.; Sena-Cruz, José

    2015-01-01

    The usage of rebars in construction is the most common method for reinforcing plain concrete and thus bridging the tensile stresses along the concrete crack surfaces. Usually design codes for modelling the bond behaviour of rebars and concrete suggest a local bond stress – slip relationship that comprises distinct reinforcement mechanisms, such as adhesion, friction and mechanical anchorage. In this work, numerical simulations of pullout tests were performed using the finite element method fr...

  9. Gigantol Suppresses Cancer Stem Cell-Like Phenotypes in Lung Cancer Cells

    OpenAIRE

    Narumol Bhummaphan; Pithi Chanvorachote

    2015-01-01

    As cancer stem cells (CSCs) contribute to malignancy, metastasis, and relapse of cancers, potential of compound in inhibition of CSCs has garnered most attention in the cancer research as well as drug development fields recently. Herein, we have demonstrated for the first time that gigantol, a pure compound isolated from Dendrobium draconis, dramatically suppressed stem-like phenotypes of human lung cancer cells. Gigantol at nontoxic concentrations significantly reduced anchorage-independent ...

  10. LGBT Workplace Climate in Astronomy

    Science.gov (United States)

    Gaudi, B. S.; Danner, R.; Dixon, W. V.; Henderson, C. B.; Kay, L. E.

    2013-01-01

    The AAS Working Group on LGBTIQ Equality (WGLE) held a town hall meeting at the 220th AAS meeting in Anchorage to explore the workplace climate for LGBTIQ individuals working in Astronomy and related fields. Topics of discussion included anti-discrimination practices, general workplace climate, and pay and benefit policies. Four employment sectors were represented: industry, the federal government, private colleges, and public universities. We will summarize and expand on the town hall discussions and findings of the panel members.

  11. Factors influencing the large-scale distribution of Hg° in the Mexico City area and over the North Pacific

    OpenAIRE

    D. Blake; S. Vay; Sachse, G.; Browell, E.; Avery, M.; J. Dibb; E. Scheuer; H. Mao; Talbot, R.; Huey, G.; H. Fuelberg

    2007-01-01

    Gas-phase elemental mercury (Hg°) was measured aboard the NASA DC-8 aircraft during the Intercontinental Chemical Transport Experiment Phase B (INTEX-B) campaign in spring 2006. Flights were conducted around Mexico City and on two subsequent deployments over the North Pacific based out of Honolulu, Hawaii and Anchorage, Alaska. Data obtained from 0.15–12 km altitude showed that Hg° exhibited a relatively constant vertical profile centered around 100 ppqv. Highly concentrated pol...

  12. Factors influencing the large-scale distribution of Hg° in the Mexico City area and over the North Pacific

    OpenAIRE

    Talbot, R.; H. Mao; E. Scheuer; J. Dibb; Avery, M.; Browell, E.; Sachse, G.; S. Vay; D. Blake; Huey, G.; H. Fuelberg

    2008-01-01

    Gas-phase elemental mercury (Hg°) was measured aboard the NASA DC-8 aircraft during the Intercontinental Chemical Transport Experiment Phase B (INTEX-B) campaign in spring 2006. Flights were conducted around Mexico City and on two subsequent deployments over the North Pacific based out of Honolulu, Hawaii and Anchorage, Alaska. Data obtained from 0.15–12 km altitude showed that Hg° exhibited a relatively constant vertical profile centered around 100 ppqv. Highl...

  13. Factors influencing the large-scale distribution of Hg° in the Mexico City area and over the North Pacific

    OpenAIRE

    Talbot, R.; H. Mao; E. Scheuer; J. Dibb; Avery, M.; Browell, E.; Sachse, G.; S. Vay; D. Blake; Huey, G.; H. Fuelberg

    2008-01-01

    International audience Gas-phase elemental mercury (Hg°) was measured aboard the NASA DC-8 aircraft during the Intercontinental Chemical Transport Experiment Phase B (INTEX-B) campaign in spring 2006. Flights were conducted around Mexico City and on two subsequent deployments over the North Pacific based out of Honolulu, Hawaii and Anchorage, Alaska. Data obtained from 0.15?12 km altitude showed that Hg° exhibited a relatively constant vertical profile centered around 100 ppqv. Highly conc...

  14. Reactive Oxygen Generated by NADPH Oxidase 1 (Nox1) Contributes to Cell Invasion by Regulating Matrix Metalloprotease-9 Production and Cell Migration*

    OpenAIRE

    Shinohara, Masahiro; Adachi, Yoshifumi; Mitsushita, Junji; Kuwabara, Mitsuhiro; Nagasawa, Atsushi; Harada, Saori; Furuta, Shuichi; Zhang, Yugen; Seheli, Kajla; Miyazaki, Hitoshi; Kamata, Tohru

    2009-01-01

    A mediating role of the reactive oxygen species-generating enzyme Nox1 has been suggested for Ras oncogene transformation phenotypes including anchorage-independent cell growth, augmented angiogenesis, and tumorigenesis. However, little is known about whether Nox1 signaling regulates cell invasiveness. Here, we report that the cell invasion activity was augmented in K-Ras-transformed normal rat kidney cells and attenuated by transfection of Nox1 small interference RNAs (siRNAs) into the cells...

  15. Targeted Disruption of the LAMA3 Gene in Mice Reveals Abnormalities in Survival and Late Stage Differentiation of Epithelial Cells

    OpenAIRE

    Ryan, Maureen C.; Lee, Keesook; Miyashita, Yuko; Carter, William G.

    1999-01-01

    Laminin 5 regulates anchorage and motility of epithelial cells through integrins α6β4 and α3β1, respectively. We used targeted disruption of the LAMA3 gene, which encodes the α3 subunit of laminin 5 and other isoforms, to examine developmental functions that are regulated by adhesion to the basement membrane (BM). In homozygous null animals, profound epithelial abnormalities were detected that resulted in neonatal lethality, consistent with removal of all α3-laminin isoforms from epithelial B...

  16. 33 CFR 110.84b - Buffalo, N.Y.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Buffalo, N.Y. 110.84b Section 110... REGULATIONS Special Anchorage Areas § 110.84b Buffalo, N.Y. The area within the Port of Buffalo known as Port of Buffalo Small Boat Harbor commencing at a point on shore at latitude 42°51′05″ N., longitude...

  17. Evolutionary learning of regularization networks with product kernel units

    Czech Academy of Sciences Publication Activity Database

    Vidnerová, Petra; Neruda, Roman

    Piscataway: IEEE, 2011, s. 638-643. ISBN 978-1-4577-0652-3. ISSN 1062-922X. [SMC 2011. International Conference on Systems, Man and Cybernetics. Anchorage (US), 09.10.2011-12.10.2011] R&D Projects: GA ČR GAP202/11/1368; GA AV ČR KJB100300804 Institutional research plan: CEZ:AV0Z10300504 Keywords : genetic algorithms * kernel functions * regularization networks Subject RIV: IN - Informatics, Computer Science

  18. The term basal plate of the human placenta as a source of functional extravillous trophoblast cells

    OpenAIRE

    Borbely, Alexandre U; Sandri, Silvana; Fernandes, Isabella R; Prado, Karen M; Cardoso, Elaine C; Correa-Silva, Simone; Albuquerque, Renata; Knöfler, Martin; Beltrão-Braga, Patricia; Campa, Ana; Bevilacqua, Estela

    2014-01-01

    Background Extravillous trophoblast (EVT) cells are of pivotal importance in human embryo implantation and homeostasis of the maternal fetal interface. Invasion of the endometrium by EVT contributes to placental anchorage, spiral artery remodeling, immunological defense, tolerogenic responses, and several collaborative cross talks involved in establishing and maintaining a successful pregnancy. We report here an improved protocol for the isolation of fully differentiated EVT cells from the ba...

  19. Bond between textile-reinforced mortar (TRM) and concrete substrates: experimental investigation

    OpenAIRE

    Raoof, Saad M.; Koutas, Lampros N.; Bournas, Dionysios A.

    2016-01-01

    This paper presents an extended experimental study on the bond behaviour between textile-reinforced mortar (TRM) and concrete substrates. The parameters examined include: (a) the bond length (from 50 mm to 450 mm); (b) the number of TRM layers (from one to four); (c) the concrete surface preparation (grinding versus sandblasting); (d) the concrete compressive strength (15 MPa or 30 MPa); (e) the textile coating; and (f) the anchorage through wrapping with TRM jackets. For this purpose, a tota...

  20. hiPS-MSCs differentiation towards fibroblasts on a 3D ECM mimicking scaffold

    OpenAIRE

    Xu, Ruodan; Taskin, Mehmet Berat; Rubert, Marina; Seliktar, Dror; Besenbacher, Flemming; Chen, Menglin

    2015-01-01

    Fibroblasts are ubiquitous cells that constitute the stroma of virtually all tissues and play vital roles in homeostasis. The poor innate healing capacity of fibroblastic tissues is attributed to the scarcity of fibroblasts as collagen-producing cells. In this study, we have developed a functional ECM mimicking scaffold that is capable to supply spatial allocation of stem cells as well as anchorage and storage of growth factors (GFs) to direct stem cells differentiate towards fibroblasts. Ele...

  1. Mallas macroporosas bioestables con aplicación en implantes protésicos y trasplante de células.

    OpenAIRE

    Antolinos Turpín, Carmen María

    2015-01-01

    [EN] This thesis has focused mainly on the synthesis and characterization of biostable macroporous polymers from the family of polyacrylates, for application in regenerative medicine. Scaffolds and membranes developed in this work can have different applications in regenerative medicine that require the transplantation of cells to the organism. In particular, ring of cornea prosthesis, anchorage of bone prosthesis, articular cartilage, and dressing for stem cell transplantation on skin regene...

  2. Identification of Distinct Breast Cancer Stem Cell Populations Based on Single-Cell Analyses of Functionally Enriched Stem and Progenitor Pools

    OpenAIRE

    Nina Akrap; Daniel Andersson; Eva Bom; Pernilla Gregersson; Anders Ståhlberg; Göran Landberg

    2016-01-01

    Summary The identification of breast cancer cell subpopulations featuring truly malignant stem cell qualities is a challenge due to the complexity of the disease and lack of general markers. By combining extensive single-cell gene expression profiling with three functional strategies for cancer stem cell enrichment including anchorage-independent culture, hypoxia, and analyses of low-proliferative, label-retaining cells derived from mammospheres, we identified distinct stem cell clusters in b...

  3. Carcinoembryonic antigen is anchored to membranes by covalent attachment to a glycosylphosphatidylinositol moiety: identification of the ethanolamine linkage site.

    OpenAIRE

    Hefta, S A; Hefta, L J; Lee, T.D. (Taunia D.); Paxton, R J; Shively, J. E.

    1988-01-01

    The COOH-terminal amino acid of carcinoembryonic antigen (CEA) is shown to covalently link with ethanolamine, evidence consistent with the anchorage of CEA to the plasma membrane through a phosphatidylinositol-glycan tail. Purified CEA was digested with trypsin, and the resulting peptides were isolated by reverse-phase HPLC. Tryptic hexapeptide T12, terminating atypically with alanine, corresponded in sequence (Ser-Ile-Thr-Val-Ser-Ala) with the last six residues (637-642) of the third repeati...

  4. Hyaluronan Constitutively Regulates Activation of COX-2-mediated Cell Survival Activity in Intestinal Epithelial and Colon Carcinoma Cells*

    OpenAIRE

    Misra, Suniti; Obeid, Lina M.; Hannun, Yusuf A.; Minamisawa, Susumu; Berger, Franklin G.; Markwald, Roger R.; Toole, Bryan P.; Ghatak, Shibnath

    2008-01-01

    Hyaluronan is a major component of the pericellular matrix surrounding tumor cells, including colon carcinomas. Elevated cycooxygenase-2 levels have been implicated in several malignant properties of colon cancer. We now show for the first time a strong link between hyaluronan-CD44 interaction and cyclooxygenase-2 in colon cancer cells. First, we have shown that increased expression of hyaluronan synthase-2 induces malignant cell properties, including increased proliferation, anchorage-indepe...

  5. Perturbation of Hyaluronan Interactions Inhibits Malignant Properties of Glioma Cells

    OpenAIRE

    Ward, Jeanine A; Huang, Lei; Guo, Huiming; Ghatak, Shibnath; Toole, Bryan P.

    2003-01-01

    Malignant progression of gliomas is characterized by acquisition of inappropriate growth and invasive properties. In vitro, these malignant properties are reflected in, and measured by, the ability to grow in an anchorage-independent manner and to invade artificial extracellular matrices. The results of numerous studies have suggested that the extracellular and pericellular matrix polysaccharide, hyaluronan, plays an important role in these attributes of malignant cancer cells. However, with ...

  6. Instructions

    OpenAIRE

    Production, Co-Action Publishing

    2005-01-01

    Scope and purpose. The International Journal of Circumpolar Health is published by the International Union for Circumpolar Health, the Nordic Society of Arctic Medicine, the University of Oulu, the University of Alaska, Anchorage, and the University of Manitoba. The journal follows the tradition initiated by its predecessor, Arctic Medical Research. The journal specializes in Arctic and Antarctic health issues. It provides a forum for many disciplines, including the biomedical sciences, socia...

  7. Experimental investigations and seismic analysis for benchmark study of 1000 MW WWER type units (water-cooled and moderated reactor) nuclear power plant Kozloduy. Final report

    International Nuclear Information System (INIS)

    This final report covers the experimental investigations and seismic analysis for benchmark study of WWER-1000 type units of Kozloduy NPP. A description of the research carried out includes terms of reference, criteria, design parameters and method of analysis, description of mathematical models developed, method for verification of anchorage components and results obtained by the mentioned methods. Experimental investigations concerned with verification of seismic safety related components are described with the conclusions drawn

  8. Clinical application of 3D imaging for assessment of treatment outcomes

    OpenAIRE

    Cevidanes, Lucia H.C.; Oliveira, Ana Emilia Figueiredo; Grauer, Dan; Styner, Martin; Proffit, William R.

    2011-01-01

    This paper outlines the clinical application of CBCT for assessment of treatment outcomes, and discusses current work to superimpose digital dental models and 3D photographs. Superimposition of CBCTs on stable structures of reference now allow assessment of 3D dental, skeletal and soft tissue changes for both growing and non-growing patients. Additionally, we describe clinical findings from CBCT superimpositions in assessment of surgery and skeletal anchorage treatment.

  9. Construcción de esculturas de hormigón con elementos procedentes del reciclado

    OpenAIRE

    Ivorra, S.; Maciá, A.; Saval, J. M.

    2010-01-01

    This paper shows the conceptual development, project, constructive and execution processes of a group of seven sculptures designed to act as containers of other art works carried out by the Spanish artist Jesús Soler. This sculptural group bases its message on the sustainability and the recycling of materials. Its fundamental boundary conditions are the capacity to be mounted and dismounted without any anchorage to the soil, durability and protection of the art work in front of meteorological...

  10. Connections in Precast Buildings using Ultra High-Strength Fibre Reinforced Concrete

    DEFF Research Database (Denmark)

    Hansen, Lars Pilegaard

    1995-01-01

    Ultra high-strength concrete adds new dimensions to the design of concrete structures. It is a brittle material but introducing fibres into the matrix changes the material into a highly ductile material. Furthermore, the fibre reinforcement increases the anchorage of traditional reinforcement bars...... and the fire resistance. Such a fibre reinforced ultra high-strength material has been used to develop a simple joint solution between slab elements in a column - slab building system....

  11. Employment Protection, Flexibility and Firms’ Strategic Location Decisions under Uncertainty

    OpenAIRE

    Dewit, Gerda; Leahy, Dermot; Montagna, Catia

    2013-01-01

    We construct a model in which oligopolistic firms decide between locating in a country where employment protection implies costly output adjustments and in one without employment protection. Using a two-period three-stage game with uncertainty, we demonstrate that location is influenced by both flexibility and strategic concerns. The strategic effects under Cournot work towards domestic anchorage in the country with employment protection while those under Bertrand do not. St...

  12. Employment Protection and Globalization in Dynamic Oligopoly

    OpenAIRE

    Dewit, Gerda; Leahy, Dermot; Montagna, Catia

    2003-01-01

    We construct a model in which oligopolistic firms decide where to locate. Firms choose to locate either in a country where employment protection implies costly output adjustments or in one without adjustment costs. Using a two-period three-stage game with uncertainty it is demonstrated that location is influenced by both flexibility and strategic concerns. We show that the strategic effects under Cournot work towards domestic anchorage in the country with adjustment costs while those under Be...

  13. Function and regulation of transcription factors involved in root apical meristem and stem cell maintenance

    OpenAIRE

    Drisch, Rebecca C.; Stahl, Yvonne

    2015-01-01

    Plant roots are essential for overall plant development, growth, and performance by providing anchorage in the soil and uptake of nutrients and water. The primary root of higher plants derives from a group of pluripotent, mitotically active stem cells residing in the root apical meristem (RAM) which provides the basis for growth, development, and regeneration of the root. The stem cells in the Arabidopsis thaliana RAM are surrounding the quiescent center (QC), which consists of a group of rar...

  14. Shear behaviour of reinforced phyllite concrete beams

    International Nuclear Information System (INIS)

    Highlights: ► Phyllite concrete beams often exhibited shear with anchorage bond failure. ► Different shear design provisions for reinforced phyllite beams are compared. ► Predicted shear capacity of phyllite beams must be modified by a reduction factor. -- Abstract: The shear behaviour of concrete beams made from phyllite aggregates subjected to monotonic and cyclic loading is reported. First diagonal shear crack load of beams with and without shear reinforcement was between 42–58% and 42–92% of the failure loads respectively. The phyllite concrete beams without shear links had lower post-diagonal cracking shear resistance compared to corresponding phyllite beams with shear links. As a result of hysteretic energy dissipation, limited cyclic loading affected the stiffness, strength and deformation of the phyllite beams with shear reinforcement. Generally, beams with and without shear reinforcement showed anchorage bond failure in addition to the shear failure due to high stress concentration near the supports. The ACI, BS and EC codes are conservative for the prediction of phyllite concrete beams without shear reinforcement but they all overestimate the shear strength of phyllite concrete beams with shear reinforcement. It is recommended that the predicted shear capacity of phyllite beams reinforced with steel stirrups be modified by a reduction factor of 0.7 in order to specify a high enough safety factor on their ultimate strength. It is also recommended that susceptibility of phyllite concrete beams to undergo anchorage bond failure is averted in design by the provision of greater anchorage lengths than usually permitted.

  15. Strontium coating by electrochemical deposition improves implant osseointegration in osteopenic models

    OpenAIRE

    LIANG, YONGQIANG; Li, Haoyan; Xu, Jiang; Li, Xin; LI, XINCHANG; Yan, Yuting; QI, MENGCHUN; Hu, Min

    2014-01-01

    Osteopenia, a preclinical state of osteoporosis, restricts the application of adult orthodontic implant anchorage and tooth implantation. Strontium (Sr) is able to promote bone formation and inhibit bone absorption. The aim of the present study was to evaluate a new method for improving the success rate of dental implantation. In this study, an electrochemical deposition (ECD) method was used to prepare a Sr coating on a titanium implant. The coating composition was investigated by energy dis...

  16. Osseointegration by bone morphogenetic protein-2 and transforming growth factor beta2 coated titanium implants in femora of New Zealand white rabbits

    OpenAIRE

    Fritz Thorey; Henning Menzel; Corinna Lorenz; Gerhard Gross; Andrea Hoffmann; Henning Windhagen

    2011-01-01

    Background: Intramembranous bone formation is essential in uncemented joint replacement to provide a mechanical anchorage of the implant. Since the discovery of bone morphogenic proteins (BMPs) by Urist in 1965, many studies have been conducted to show the influence of growth factors on implant ingrowth. In this study, the influence of bone morphogenetic protein-2 (rhBMP-2) and transforming growth factor β2 (TGF-β2) on implant osseointegration was investigated. Materials and Methods: Thir...

  17. Osseointegration by bone morphogenetic protein-2 and transforming growth factor beta2 coated titanium implants in femora of New Zealand white rabbits

    Directory of Open Access Journals (Sweden)

    Fritz Thorey

    2011-01-01

    Conclusions: No differences between BMP-2 alone and a combination of BMP-2+TGF-β2 could be seen in the present study. However, the results of this study confirm the results of other studies that a coating with growth factors is able to enhance bone implant ingrowth. This may be of importance in defect situations during revision surgery to support the implant ingrowth and implant anchorage.

  18. Implant-retained craniofacial prostheses for facial defects

    OpenAIRE

    Federspil, Philipp A.

    2011-01-01

    Craniofacial prostheses, also known as epistheses, are artificial substitutes for facial defects. The breakthrough for rehabilitation of facial defects with implant-retained prostheses came with the development of the modern silicones and bone anchorage. Following the discovery of the osseointegration of titanium in the 1950s, dental implants have been made of titanium in the 1960s. In 1977, the first extraoral titanium implant was inserted in a patient. Later, various solitary extraoral impl...

  19. Friction in orthodontics

    OpenAIRE

    Prashant, P. S.; Nandan, Hemant; Gopalakrishnan, Meera

    2015-01-01

    Conventional wisdom suggests that resistance to sliding (RS) generated at the wire-bracket interface has a bearing on the force transmitted to the teeth. The relative importance of static and kinetic friction and also the effect of friction on anchorage has been a topic of debate. Lot of research work has been done to evaluate the various factors that affect friction and thus purportedly retards the rate of tooth movement. However, relevancy of these studies is questionable as the methodology...

  20. Bond between textile-reinforced mortar (TRM) and concrete substrates: Experimental investigation

    OpenAIRE

    Raoof, Saad M.; Koutas, Lampros N.; Bournas, Dionysios A.

    2016-01-01

    This paper presents an extended experimental study on the bond behaviour between textile-reinforced mortar (TRM) and concrete substrates. The parameters examined include: (a) the bond length (from 50 mm to 450 mm); (b) the number of TRM layers (from one to four); (c) the concrete surface preparation (grinding versus sandblasting); (d) the concrete compressive strength (15 MPa or 30 MPa); (e) the textile coating; and (f) the anchorage through wrapping with TRM jackets. For this purpose, a tota...

  1. Generation of transforming viruses in cultures of chicken fibroblasts infected with an avian leukosis virus.

    OpenAIRE

    Stavnezer, E; Gerhard, D S; Binari, R C; Balazs, I.

    1981-01-01

    During serial passages of an avian leukosis virus (the transformation-defective, src deletion mutant of Bratislava 77 avian sarcoma virus, designated tdB77) in chicken embryo fibroblasts, viruses which transformed chicken embryo fibroblasts in vitro emerged. Chicken embryo fibroblasts infected with these viruses (SK770 and Sk780) had a distinctive morphology, formed foci in monolayer cultures, and grew independent of anchorage in semisolid agar. Bone marrow cells were not transformed by these...

  2. Influence of receptor lateral mobility on adhesion strengthening between membranes containing LFA-3 and CD2

    OpenAIRE

    1991-01-01

    We have used an in vitro model system of glass-supported planar membranes to study the effects of lateral mobility of membrane-bound receptors on cell adhesion. Egg phosphatidylcholine (PC) bilayers were reconstituted with two anchorage isoforms of the adhesion molecule lymphocyte function-associated antigen 3 (LFA-3). The diffusion coefficient of glycosyl phosphatidylinositol (GPI)-anchored LFA-3 approached that of phospholipids in the bilayers, whereas the transmembrane (TM)-anchored isofor...

  3. The Use of MMF Screws: Surgical Technique, Indications, Contraindications, and Common Problems in Review of the Literature

    OpenAIRE

    Cornelius, Carl-Peter; Ehrenfeld, Michael

    2010-01-01

    Mandibulo-maxillary fixation (MMF) screws are inserted into the bony base of both jaws in the process of fracture realignment and immobilisation. The screw heads act as anchor points to fasten wire loops or rubber bands connecting the mandible to the maxilla. Traditional interdental chain-linked wiring or arch bar techniques provide the anchorage by attached cleats, hooks, or eyelets. In comparison to these tooth-borne appliances MMF screws facilitate and shorten the way to achieve intermaxil...

  4. Management of Velopharyngeal Defects: A Review

    OpenAIRE

    Shetty, Nitin Bhaskar; Shetty, Sanyuktha; E., Nagraj; D’Souza, Raina; Shetty, Omkar

    2014-01-01

    Success in Maxillofacial Prosthetics depends on full cognizance of the principles that underlie facial harmony, anchorage and retention, weight bearing and leverage, durability, tissue compatibility and tolerance. The maxillofacial prosthodontist normally provides appliances to restore aesthetics and function to the patients who cannot be restored to normal appearances or functions by means of plastic reconstructions. The velopharynx is a dynamic anatomic structure which is essential for norm...

  5. Cold laminar galvanizing: a new anti-corrosion concept

    International Nuclear Information System (INIS)

    Cold laminar galvanizing, a recent anticorrosion technology, now combines the most positive characteristics of the hot galvanizing protective systems. This patented technology has a zinc laminated foil (obtained by processing 99.9% pure zinc ingots) that is homogeneous and isotropic, with a standard thickness of 80-100μm. This foil is backed with an electro-conductive, selfadhesive glue prepared under an original formula. The zinc laminated foil offers excellent anchorage and elevated resistance to the main atmospheric agents

  6. 49 CFR 571.201 - Standard No. 201; Occupant protection in interior impact.

    Science.gov (United States)

    2010-10-01

    ... incorporates an upper seat belt anchorage conforming to the requirements of S4.2.1 and S4.3.2 of 49 CFR 571.210... the requirements of S4.2.1 and S4.3.2 of 49 CFR 571.210, that is located forward of the rearmost... occupant crash protection requirements of S5.1 of 49 CFR 571.208 by means of inflatable restraint...

  7. Thermo-mechanical properties of commercially available epoxy resins for structural applications

    OpenAIRE

    Michels, Julien; Sena-Cruz, José; Czaderski, Christoph; Motavalli, Masoud

    2015-01-01

    Externally bonded (EB) or Near-Surface-Mounted (NSM) composite reinforcements are often bonded to a cementitious substrate by means of commercially available epoxies. These twocomponent- resins are generally ‘cold-curing’ (at room temperature), having however the ability to cure faster under elevated temperatures. One application requesting such an accelerated curing process is the gradient anchorage for strengthening of concrete structures with prestressed CFRP laminates, based o...

  8. mTOR ATP-competitive inhibitor INK128 inhibits neuroblastoma growth via blocking mTORC signaling

    OpenAIRE

    Zhang, Huiyuan; Dou, Jun; Yu, Yang; Zhao, Yanling; Fan, Yihui; Cheng, Jin; Xu, Xin; Liu, Wei; Guan, Shan; Chen, Zhenghu; Shi, Yan; Patel, Roma; Vasudevan, Sanjeev A.; Zage, Peter E; Zhang, Hong

    2015-01-01

    High-risk neuroblastoma often develops resistance to high-dose chemotherapy. The mTOR signaling cascade is frequently deregulated in human cancers and targeting mTOR signaling sensitizes many cancer types to chemotherapy. Here, using a panel of neuroblastoma cell lines, we found that the mTOR inhibitor INK128 showed inhibitory effects on both anchorage-dependent and independent growth of neuroblastoma cells and significantly enhanced the cytotoxic effects of doxorubicin (Dox) on these cell li...

  9. Understanding Energy Code Acceptance within the Alaska Building Community

    Energy Technology Data Exchange (ETDEWEB)

    Mapes, Terry S.

    2012-02-14

    This document presents the technical assistance provided to the Alaska Home Financing Corporation on behalf of PNNL regarding the assessment of attitudes toward energy codes within the building community in Alaska. It includes a summary of the existing situation and specific assistance requested by AHFC, the results of a questionnaire designed for builders surveyed in a suburban area of Anchorage, interviews with a lender, a building official, and a research specialist, and recommendations for future action by AHFC.

  10. An adult bimaxillary protrusion treated with corticotomy-facilitated orthodontics and titanium miniplates.

    Science.gov (United States)

    Iino, Shoichiro; Sakoda, Sumio; Miyawaki, Shouichi

    2006-11-01

    We performed an orthodontic treatment combined with corticotomy and the placement of titanium miniplates in an adult patient who desired a shortened treatment period. The patient had an Angle Class I malocclusion with flaring of the maxillary and mandibular incisors. First, titanium miniplates were placed into the buccal alveolar bone of the maxilla for absolute orthodontic anchorage. Second, an edgewise appliance was applied to the maxillary and mandibular teeth. Then, the maxillary first premolars and mandibular second premolars were extracted. At the same time, a corticotomy was performed on the cortical bone of the lingual and buccal sides in the maxillary anterior as well as the mandibular anterior and posterior regions. Leveling was initiated immediately after the corticotomy. The extraction spaces were closed with conventional orthodontic force (approximately 1 N per side). The edgewise appliance was adjusted once every 2 weeks. The total treatment time was 1 year. Cephalometric superimpositions showed no anchorage loss, and panoramic radiographs showed neither significant reduction in the crest bone height nor marked apical root resorption. A corticotomy-facilitated orthodontic treatment with titanium miniplates might shorten an orthodontic treatment period without any anchorage loss or adverse effects. PMID:17090169

  11. Torque control in lingual orthodontics with lever arm mechanics: a case report.

    Science.gov (United States)

    Aravind, M; Shivaprakash, G; Ramesh, G C

    2013-01-01

    The aim of this report is to illustrate treatment mechanics for torque control in lingual mechanotherapy using a lever arm and transpalatal arch (TPA) tab system during en masse retraction of anterior teeth. An 18-year-old female with bimaxillary dentoalveolar proclination with crowding was treated with a lever arm-TPA tab system. The retraction tabs bent into the TPA placed across the maxillary second molars were used as anchorage. The retraction force on the maxillary anterior teeth was applied using lever arm hooks soldered between the lateral incisors and canines on a lingual mushroom archwire. By applying a retraction force to the lever arm hooks, the maxillary anterior teeth experienced greater palatal root movement as compared to the conventional retraction forces applied at the crown level. The tabs, placed high in the TPA, produced a distal tipping moment on the maxillary second molars, reinforcing their anchorage. The retraction force applied to the long lever arm hooks from the TPA tabs at the level of center of resistance (CRes) of anterior and posterior teeth is advantageous mainly in two aspects. First, it reinforces the anchorage, and second, it favors the palatal root movement of anterior teeth, thus obtaining better control over the torque during en masse retraction. PMID:23646329

  12. Phenotypical Reversion and Differentiation of Breast Cancer in vitro by Sodium Phenylacetate

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Objective To evaluate the effect of a nontoxic differentiation inducer, sodium phenylacetate (NaPA) on breast cancer MCF-7 and MDA-453 cells in vitro. Methods The anchorage growth assay, ELISA, immunofluorescence analysis and electron microscopy were used to study the effect of NaPA on MCF-7 and MDA-453 cells. Results NaPA treatment resulted in a dose-dependent inhibition of MCF-7 or MDA-453 cell growth, including anchorage-dependent and anchorage-independent growth, but il did not significantly inhibit the growth of normal amnion tissue Wish cells and adult hepatic cells L-02. In addition, NaPA could enhance the expressions of intercellular adhesion molecule-1(ICAM-1), human leukocyte antigen ( HLA ) class Ⅰ and Ⅱ molecules on the surface of MCF-7 and MDA-453 cells. Electron micrographs demonstrated richer rough endoplasmic reticulum,mitochondria in NaPA-treated MCF-7 and MDA-453 cells, in contrast to the scant before-mentwned structures but scattered cytoplasmic polyribosomes in the untreated ones. Conclusion NaPA is effective in inducing phenotype reversion and differentiation of breast cancer, and potential in cancer intervention.

  13. A three-dimensional self-opening intraneural peripheral interface (SELINE)

    Science.gov (United States)

    Cutrone, A.; Del Valle, J.; Santos, D.; Badia, J.; Filippeschi, C.; Micera, S.; Navarro, X.; Bossi, S.

    2015-02-01

    Objective. In this study we present the development and testing in a rat model of the self-opening neural interface (SELINE), a novel flexible peripheral neural interface. Approach. This polyimide-based electrode has a three-dimensional structure that provides an anchorage system to the nerve and confers stability after implant. This geometry has been achieved by means of the plastic deformation of polyimide. Mechanical and electrochemical characterizations have been performed to prove the integrity of the electrode with very good results. Functionality of SELINEs for fascicular stimulation has been tested during in vivo acute experiments in the rat. Chronic implants were made to test the biocompatibility of the device. Main results. Results showed that SELINEs significantly improve mechanical anchorage to the nerve. Stimulation stability is considerably enhanced compared to common planar transversal electrodes and stimulation selectivity is increased for some motor fascicles. Chronic experimental results showed that SELINEs neither produce changes in the fascicular organization of sciatic nerves nor signs of nerve degeneration. Significance. The presented three-dimensional electrode provides an effective anchorage system to the nervous tissue that can improve the stability of the implant for acute and chronic studies.

  14. Finite element analysis on stress distribution of maxillary implant-retained overdentures depending on the Bar attachment design and palatal coverage

    Science.gov (United States)

    2016-01-01

    PURPOSE The purpose of this study was to determine the effect of anchorage systems and palatal coverage of denture base on load transfer in maxillary implant-retained overdenture. MATERIALS AND METHODS Maxillary implant-retained overdentures with 4 implants placed in the anterior region of edentulous maxilla were converted into a 3-D numerical model, and stress distribution patterns in implant supporting bone in the case of unilateral vertical loading on maxillary right first molar were compared with each other depending on various types of anchorage system and palatal coverage extent of denture base using three-dimensional finite element analysis. RESULTS In all experimental models, the highest stress was concentrated on the most distal implant and implant supporting bone on loaded side. The stress at the most distal implant-supporting bone was concentrated on the cortical bone. In all anchorage system without palatal coverage of denture base, higher stresses were concentrated on the most distal implant and implant supporting bone on loaded side. CONCLUSION It could be suggested that when making maxillary implant retained overdenture, using Hader bar instead of milled bar and full palatal coverage rather than partial palatal coverage are more beneficial in distributing the stress that is applied on implant supporting bone. PMID:27141251

  15. Dissipation of Impact Stress Waves within the Artificial Blasting Damage Zone in the Surrounding Rocks of Deep Roadway

    Directory of Open Access Journals (Sweden)

    Jianguo Ning

    2016-01-01

    Full Text Available Artificial explosions are commonly used to prevent rockburst in deep roadways. However, the dissipation of the impact stress wave within the artificial blasting damage zone (ABDZ of the rocks surrounding a deep roadway has not yet been clarified. The surrounding rocks were divided into the elastic zone, blasting damage zone, plastic zone, and anchorage zone in this research. Meanwhile, the ABDZ was divided into the pulverizing area, fractured area, and cracked area from the inside out. Besides, the model of the normal incidence of the impact stress waves in the ABDZ was established; the attenuation coefficient of the amplitude of the impact stress waves was obtained after it passed through the intact rock mass, and ABDZ, to the anchorage zone. In addition, a numerical simulation was used to study the dynamic response of the vertical stress and impact-induced vibration energy in the surrounding rocks. By doing so, the dissipation of the impact stress waves within the ABDZ of the surrounding rocks was revealed. As demonstrated in the field application, the establishment of the ABDZ in the surrounding rocks reduced the effect of the impact-induced vibration energy on the anchorage support system of the roadway.

  16. Application study on the first cable-stayed bridge with CFRP cables in China

    Directory of Open Access Journals (Sweden)

    Kuihua Mei

    2015-08-01

    Full Text Available In order to push forward the development of CFRP cable-stayed bridge and accumulate experiences, the study on the application of the first cable-stayed bridge with CFRP cables in China was carried out. The design essentials of main components of the bridge were introduced and its integral performances, including static properties, dynamic properties and seismic response were analyzed using finite element method. A new bond-type anchorage was developed and the processes of fabricating and installing CFRP cables were elaborated. Based on the results of construction simulation, a tension scheme for bridge was propound. During constructing, the stresses and displacement of girder and pylon, as well as the forces and stresses of cables, were tested. The results indicate that all sections of the bridge could meet the requirements of the ultimate bearing capacity and normal service; the performance of the anchorage is good and the stresses in each cable system are similar; the tested values accord well with the calculated values. Further, creep deformation of the resin in anchorages under service load is not obvious. All these results demonstrate that the first application of CFRP cables in the cable-stayed bridge in China is successful.

  17. miR-1301 promotes prostate cancer proliferation through directly targeting PPP2R2C.

    Science.gov (United States)

    Bi, Dongbin; Ning, Hao; Liu, Shuai; Que, Xinxiang; Ding, Kejia

    2016-07-01

    Prostate cancer is the leading cause of cancer deaths among men in the worldwide, it's important to find new prognostic factors and therapeutic targets. microRNAs play critical roles in the development and progression of prostate cancer. Here we revealed miR-1301 promoted prostate cancer progression. miR-1301 was upregulated in prostate cancer tissues and cells, overexpression of miR-1301 promoted anchorage-dependent and -independent growth using MTT analysis, colony formation analysis and soft agar growth analysis, whereas knockdown of miR-1301 suppressed anchorage-dependent and -independent growth. We also found overexpression of miR-1301 inhibited p27 expression and promoted Cyclin D1 expression, whereas knockdown of miR-1301 reduced this effect, suggesting miR-1301 promoted the G1/S transition. These results suggested miR-1301 promoted cell proliferation of prostate cancer. microRNAs can inhibit target mRNA translation or/and induce mRNA degradation, we found tumor suppresser PPP2R2C was the target of miR-1301, simultaneous downregualtion of PPP2R2C and miR-1301 promoted anchorage-dependent and -independent growth. These findings suggested miR-1301 promoted prostate cancer proliferation by inhibiting PPP2R2C, and might a therapeutic target for prostate cancer. PMID:27261573

  18. Trypsin-induced changes in cell shape and chromatin structure result in radiosensitization of monolayer Chinese hamster V79 cells

    International Nuclear Information System (INIS)

    Trypsin is the enzyme commonly used to prepare single cell suspensions from monolayer and spheroid cultures, both to determine survival and to assay DNA damage. Trypsin induces rounding, dissociation and radiosensitization of anchorage-dependent cells. Radiosensitivity and chromatin structure were compared between trypsin-treated (0.05%) round V79 cells from monolayers and spheroids vs. untreated spread monolayer cells in situ. The fluorescent halo technique was used to measure the changes in DNA supercoiling in nucleoids isolated from control and irradiated round and spread cells. Maximal halo diameters, the amount of initial and residual radiation-induced SNA damage and the radiosensitivity were higher in round cells than in spread monolayer V79 cells. The effects on cellular radiosensitivity and maximal halo diameter of other agents which also round and dissociate cells, e.g. 0.25% trypsin, pronase E and a non-enzymatic cell-dissociation solution, were similar to those of 0.05% trypsin. In LY-S cells, which are anchorage-independent, DNA loop size, the initial amount of DNA damage and radiosensitivity were not affected by trypsin. We suggest that the higher radiosensitivity of anchorage-dependent cells under immediate trypsinization and plating conditions, compared to cells with postirradiation in situ repair incubation, is due to correlated changes in cell shape and chromatin structure. (author)

  19. Outcome of orthodontic mini-implant loss in relation to interleukin 6 polymorphisms.

    Science.gov (United States)

    Reichow, A M; Melo, A C; de Souza, C M; Castilhos, B B; Olandoski, M; Alvim-Pereira, C C K; Alvim-Pereira, F; Trevilatto, P C

    2016-05-01

    Mini-implants (MIs) are used increasingly for orthodontic anchorage and their success may require some osseointegration, which is affected by the underlying host immune-inflammatory response. Interleukin 6 (IL-6) is a cytokine expressed during the host response after a trauma or infection. The aim of this study was to investigate the association of clinical characteristics and IL6 tag single nucleotide polymorphisms (which capture the information of the whole gene in terms of genetic variability) with the loss of MIs for orthodontic anchorage. A total of 487 patients were treated with orthodontic MIs between 2004 and 2010. After the application of inclusion and exclusion criteria, the sample comprised 104 patients with one or more MIs that had been in function for at least 6 months with no loss, and 31 patients who had lost one or more MIs. Allele A of rs2069843 and allele T of rs2069849 were suggestively associated with the loss of MIs for orthodontic anchorage and were in complete linkage disequilibrium, which means that one of them is sufficient to capture the same information. The location of installation (mandible) and the number of MIs installed per patient were also associated with the loss of MIs. PMID:26696139

  20. Penutupan Ruang Bekas Pencabutan Premolar Satu

    Directory of Open Access Journals (Sweden)

    Evie D. D. Yashadhana

    2015-09-01

    Full Text Available The aim of the present study was to investigate the amount of protraction of the anchor teeth (M1, as  a result of the retraction of the upper anterior dentition in protrusion cases with extraction of bot upper first premolars, using only upper first permanent molars as anchorage. This condition is surprisingly paid little attention. The data were obtained from pre and post treatment upper dental casts of Class I and Class II malocclusion with protrusion and slight crowding. After ecctraction of two upper first premolars, all patients were treated with fixed appliances. Measurement was gathered by using Coordinate Measuring Machine. The findings from statistical data analysis showed that the closing of the first Premolar extraction space was caused not only by the retraction of the anterior teeth, but also by the protraction of the upper first Molars as big as 40.4%. Compared to both right and left side of the arch, the probabiity of the posterior tooth protraction was even. It was not an anchorage loss investigation but the result indeed would take clinician's more attention to control the anchorage.

  1. Comparison of topical and infiltration anesthesia for orthodontic mini-implant placement

    Directory of Open Access Journals (Sweden)

    Matheus Miotello Valieri

    2014-04-01

    Full Text Available Objective: To compare the acceptability and effectiveness of topical and infiltration anesthesia for placement of mini-implants used as temporary anchorage devices. Methods: The sample comprised 40 patients, 17 males and 23 females, whose mean age was 26 years old and who were all undergoing orthodontic treatment and in need for anchorage reinforcement. Mini-implants were bilaterally placed in the maxilla of all individuals, with infiltration anesthesia on one side and topical anesthesia on the other. These 40 patients completed two questionnaires, one before and another after mini-implant placement and pain was measured through a visual analog scale (VAS. The data collected were analyzed using descriptive statistics and the measurements of pain were compared by means of the non-parametric test of Mann-Whitney. Results: It was found that 60% of patients felt more comfortable with the use of topical anesthesia for mini-implant placement; 72.5% of patients described the occurrence of pressure during placement of the anchorage device as the most unpleasant sensation of the entire process; 62.5% of patients felt more pain with the use of topical anesthesia. Conclusion: It was concluded that patients had less pain with the use of infiltration anesthesia, and also preferred this type of anesthetic.

  2. Development and testing of texture discriminators for the analysis of trabecular bone in proximal femur radiographs

    International Nuclear Information System (INIS)

    Purpose: Texture analysis of femur radiographs may serve as a potential low cost technique to predict osteoporotic fracture risk and has received considerable attention in the past years. A further application of this technique may be the measurement of the quality of specific bone compartments to provide useful information for treatment of bone fractures. Two challenges of texture analysis are the selection of the best suitable texture measure and reproducible placement of regions of interest (ROIs). The goal of this in vitro study was to automatically place ROIs in radiographs of proximal femur specimens and to calculate correlations between various different texture analysis methods and the femurs' anchorage strength. Methods: Radiographs were obtained from 14 femoral specimens and bone mineral density (BMD) was measured in the femoral neck. Biomechanical testing was performed to assess the anchorage strength in terms of failure load, breakaway torque, and number of cycles. Images were segmented using a framework that is based on the usage of level sets and statistical in-shape models. Five ROIs were automatically placed in the head, upper and lower neck, trochanteric, and shaft compartment in an atlas subject. All other subjects were registered rigidly, affinely, and nonlinearly, and the resulting transformation was used to map the five ROIs onto the individual femora. Results: In each ROI, texture features were extracted using gray level co-occurence matrices (GLCM), third-order GLCM, morphological gradients (MGs), Minkowski dimensions (MDs), Minkowski functionals (MFs), Gaussian Markov random fields, and scaling index method (SIM). Coefficients of determination for each texture feature with parameters of anchorage strength were computed. In a stepwise multiregression analysis, the most predictive parameters were identified in different models. Texture features were highly correlated with anchorage strength estimated by the failure load of up to R2=0.61 (MF

  3. Development and testing of texture discriminators for the analysis of trabecular bone in proximal femur radiographs

    Energy Technology Data Exchange (ETDEWEB)

    Huber, M. B.; Carballido-Gamio, J.; Fritscher, K.; Schubert, R.; Haenni, M.; Hengg, C.; Majumdar, S.; Link, T. M. [Department of Radiology and Biomedical Imaging, University of California, 400 Parnassus Avenue, San Francisco, California 94143 (United States); University of Health Sciences, Medical Informatics and Technology, 6060 Hall (Austria); AO Development Institute, 7270 Davos Platz (Switzerland); Medical University Innsbruck, 6020 Innsbruck (Austria); Department of Radiology and Biomedical Imaging, University of California, 400 Parnassus Avenue, San Francisco, California 94143 (United States)

    2009-11-15

    Purpose: Texture analysis of femur radiographs may serve as a potential low cost technique to predict osteoporotic fracture risk and has received considerable attention in the past years. A further application of this technique may be the measurement of the quality of specific bone compartments to provide useful information for treatment of bone fractures. Two challenges of texture analysis are the selection of the best suitable texture measure and reproducible placement of regions of interest (ROIs). The goal of this in vitro study was to automatically place ROIs in radiographs of proximal femur specimens and to calculate correlations between various different texture analysis methods and the femurs' anchorage strength. Methods: Radiographs were obtained from 14 femoral specimens and bone mineral density (BMD) was measured in the femoral neck. Biomechanical testing was performed to assess the anchorage strength in terms of failure load, breakaway torque, and number of cycles. Images were segmented using a framework that is based on the usage of level sets and statistical in-shape models. Five ROIs were automatically placed in the head, upper and lower neck, trochanteric, and shaft compartment in an atlas subject. All other subjects were registered rigidly, affinely, and nonlinearly, and the resulting transformation was used to map the five ROIs onto the individual femora. Results: In each ROI, texture features were extracted using gray level co-occurence matrices (GLCM), third-order GLCM, morphological gradients (MGs), Minkowski dimensions (MDs), Minkowski functionals (MFs), Gaussian Markov random fields, and scaling index method (SIM). Coefficients of determination for each texture feature with parameters of anchorage strength were computed. In a stepwise multiregression analysis, the most predictive parameters were identified in different models. Texture features were highly correlated with anchorage strength estimated by the failure load of up to R{sup 2

  4. Comparative Proteomics of Ovarian Cancer Aggregate Formation Reveals an Increased Expression of Calcium-activated Chloride Channel Regulator 1 (CLCA1).

    Science.gov (United States)

    Musrap, Natasha; Tuccitto, Alessandra; Karagiannis, George S; Saraon, Punit; Batruch, Ihor; Diamandis, Eleftherios P

    2015-07-10

    Ovarian cancer is a lethal gynecological disease that is characterized by peritoneal metastasis and increased resistance to conventional chemotherapies. This increased resistance and the ability to spread is often attributed to the formation of multicellular aggregates or spheroids in the peritoneal cavity, which seed abdominal surfaces and organs. Given that the presence of metastatic implants is a predictor of poor survival, a better understanding of how spheroids form is critical to improving patient outcome, and may result in the identification of novel therapeutic targets. Thus, we attempted to gain insight into the proteomic changes that occur during anchorage-independent cancer cell aggregation. As such, an ovarian cancer cell line, OV-90, was cultured in adherent and non-adherent conditions using stable isotope labeling with amino acids in cell culture (SILAC). Anchorage-dependent cells (OV-90AD) were grown in tissue culture flasks, whereas anchorage-independent cells (OV-90AI) were grown in suspension using the hanging-drop method. Cellular proteins from both conditions were then identified using LC-MS/MS, which resulted in the quantification of 1533 proteins. Of these, 13 and 6 proteins were up-regulated and down-regulated, respectively, in aggregate-forming cells compared with cells grown as monolayers. Relative gene expression and protein expression of candidates were examined in other cell line models of aggregate formation (TOV-112D and ES-2), which revealed an increased expression of calcium-activated chloride channel regulator 1 (CLCA1). Moreover, inhibitor and siRNA transfection studies demonstrated an apparent effect of CLCA1 on cancer cell aggregation. Further elucidation of the role of CLCA1 in the pathogenesis of ovarian cancer is warranted. PMID:26004777

  5. Insulin-like growth factor-I receptor signaling blockade combined with radiation.

    Science.gov (United States)

    Allen, Gregory W; Saba, Corey; Armstrong, Eric A; Huang, Shyh-Min; Benavente, Sergio; Ludwig, Dale L; Hicklin, Daniel J; Harari, Paul M

    2007-02-01

    Signaling through the insulin-like growth factor-I receptor (IGF-IR) is implicated in cellular proliferation, apoptosis, carcinogenesis, metastasis, and resistance to cytotoxic cancer therapies. Targeted disruption of IGF-IR signaling combined with cytotoxic therapy may therefore yield improved anticancer efficacy over conventional treatments alone. In this study, a fully human anti-IGF-IR monoclonal antibody A12 (ImClone Systems, Inc., New York, NY) is examined as an adjunct to radiation therapy. IGF-IR expression is shown for a diverse cohort of cell lines, whereas targeted IGF-IR blockade by A12 inhibits IGF-IR phosphorylation and activation of the downstream effectors Akt and mitogen-activated protein kinase. Anchorage-dependent proliferation and xenograft growth is inhibited by A12 in a dose-dependent manner, particularly for non-small cell lung cancer lines. Clonogenic radiation survival of H226 and H460 cells grown under anchorage-dependent conditions is impaired by A12, demonstrating a radiation dose-enhancing effect for IGF-IR blockade. Postradiation anchorage-independent colony formation is inhibited by A12 in A549 and H460 cells. In the H460 xenograft model, combining A12 and radiation significantly enhances antitumor efficacy compared with either modality alone. These effects may be mediated by promotion of radiation-induced, double-stranded DNA damage and apoptosis as observed in cell culture. In summary, these results validate IGF-IR signal transduction blockade as a promising strategy to improve radiation therapy efficacy in human tumors, forming a basis for future clinical trials. PMID:17283150

  6. Factors influencing the large-scale distribution of Hg° in the Mexico City area and over the North Pacific

    Directory of Open Access Journals (Sweden)

    D. Blake

    2007-11-01

    Full Text Available Gas-phase elemental mercury (Hg° was measured aboard the NASA DC-8 aircraft during the Intercontinental Chemical Transport Experiment Phase B (INTEX-B campaign in spring 2006. Flights were conducted around Mexico City and on two subsequent deployments over the North Pacific based out of Honolulu, Hawaii and Anchorage, Alaska. Data obtained from 0.15–12 km altitude showed that Hg° exhibited a relatively constant vertical profile centered around 100 ppqv. Highly concentrated pollution plumes emanating from the Mexico City urban agglomeration revealed that mixing ratios of Hg° as large as 500 ppqv were related to combustion tracers such as CO, but not SO2 which is presumably released locally from coal burning, refineries, and volcanoes. Our analysis of Mexico City plumes indicated that widespread multi-source urban/industrial emissions may have a more important influence on Hg° than specific point sources. Over the Pacific, correlations with CO, CO2, CH4, and C2Cl4 were diffuse overall, but recognizable on flights out of Anchorage and Honolulu. In distinct plumes originating from the Asian continent the Hg°- CO relationship yielded an average value of ~0.56 ppqv/ppbv, in good agreement with previous findings. A prominent feature of the INTEX-B dataset was frequent total depletion of Hg° in the upper troposphere when stratospherically influenced air was encountered. Ozone data obtained with the differential absorption lidar (DIAL showed that the stratospheric impact on the tropospheric column was a common and pervasive feature on all flights out of Honolulu and Anchorage. We propose that this is likely a major factor driving large-scale seasonality in Hg° mixing ratios, especially at mid-latitudes, and an important process that should be incorporated into global chemical transport models.

  7. Factors influencing the large-scale distribution of Hg° in the Mexico City area and over the North Pacific

    Directory of Open Access Journals (Sweden)

    D. Blake

    2008-04-01

    Full Text Available Gas-phase elemental mercury (Hg° was measured aboard the NASA DC-8 aircraft during the Intercontinental Chemical Transport Experiment Phase B (INTEX-B campaign in spring 2006. Flights were conducted around Mexico City and on two subsequent deployments over the North Pacific based out of Honolulu, Hawaii and Anchorage, Alaska. Data obtained from 0.15–12 km altitude showed that Hg° exhibited a relatively constant vertical profile centered around 100 ppqv. Highly concentrated pollution plumes emanating from the Mexico City urban agglomeration revealed that mixing ratios of Hg° as large as 500 ppqv were related to combustion tracers such as CO, but not SO2 which is presumably released locally from coal burning, refineries, and volcanoes. Our analysis of Mexico City plumes indicated that widespread multi-source urban/industrial emissions may have a more important influence on Hg° than specific point sources. Over the Pacific, correlations with CO, CO2, CH4, and C2Cl4 were diffuse overall, but recognizable on flights out of Anchorage and Honolulu. In distinct plumes originating from the Asian continent the Hg°- CO relationship yielded an average value of ~0.56 ppqv/ppbv, in good agreement with previous findings. A prominent feature of the INTEX-B dataset was frequent total depletion of Hg° in the upper troposphere when stratospherically influenced air was encountered. Ozone data obtained with the differential absorption lidar (DIAL showed that the stratospheric impact on the tropospheric column was a common and pervasive feature on all flights out of Honolulu and Anchorage. We propose that this is likely a major factor driving large-scale seasonality in Hg° mixing ratios, especially at mid-latitudes, and an important process that should be incorporated into global chemical transport models.

  8. Rapid tooth movement through distraction osteogenesis of the periodontal ligament in dogs

    Institute of Scientific and Technical Information of China (English)

    AI Hong; XU Qing-feng; LU Hong-fei; MAI Zhi-hui; AN Ai-qun; LIU Guo-ping

    2008-01-01

    Background Animal models are needed for the study of rapid tooth movement into the extraction socket through distraction osteogenesis of the periodontal ligament.Methods Modified distraction devices were placed on eight dogs between the first and third mandibular premolars on the left sides;similar placement of traditional straight wise appliances on the right sides served as the control.The experimental distractors were activated(0.25 mm/d)twice a day and the control devices were activated(100 g)for two weeks with consolidation periods at weeks two,three,six,and ten.Two dogs were sacrificed at each consolidation time point;rates and patterns of tooth movement,loss of anchorage,and periapical films were evaluated,and the aftected premolars and surrounding periodontal tissues were decalcified and examined histologically.General observations,X-ray periapical filming and histology examination were performed.Results Distal movement((3.66±0.1 4)mm)measured two weeks after modified distraction exceeded that achieved using the traditional device((1.15±0.21)mm;P<0.05).Loss of anchorage was minimally averaged(0.34±0.06)mm and (0.32±0.07)mm in the experimental and control sides,respectively.By radiography,apical and lateral surface root resorptions on both sides were minimal.Alveolar bone Iesions were never evident.Fibroblasts were endched in periodontal ligaments and bone spicules formed actively along directions of distraction.Conclusions The canine model is suitable for the study of rapid tooth movement through distraction osteogenesis of the periodontal ligament.The technique accelerates tooth movement,periodontal remodeling,alveolar bone absorption,and may induce fibroblast formation,as compared to the traditional orthodontic method,without adversely affecting root absorption,bone loss,tooth mobility and anchorage loss.

  9. Global ballast water management and the "same location" concept: a clear term or a clear issue?

    Science.gov (United States)

    David, Matej; Gollasch, Stephan; Pavliha, Marko

    2013-03-01

    The United Nations recognized the transfer of harmful organisms and pathogens across natural barriers as one of the four greatest pressures to the world's oceans and seas, causing global environmental changes, while also posing a threat to human health, property, and resources. Ballast water transferred by vessels was recognized as a prominent vector of such species and was regulated by the International Convention for the Control and Management of Ship's Ballast Water and Sediments (2004). Permanent exceptions from ballast water management requirements may apply when the uptake and discharge of ballast water occur at the "same location." However, the "same location" concept may be interpreted differently, e.g., a port basin, a port, an anchorage, or a larger area even with more ports inside. Considering that the Convention is nearing the beginning of enforcement, national authorities all around the world will soon be exposed to applications for exceptions. Here we consider possible effects of different interpretations of the "same location" concept. We have considered different possible extensions of the same location through environmental, shipping, and legal aspects. The extension of such areas, and the inclusion of more ports, may compromise the Convention's main purpose. We recommend that "same location" mean the smallest practicable unit, i.e., the same harbor, mooring, or anchorage. An entire smaller port, possibly also including the anchorage, could be considered as same location. For larger ports with a gradient of environmental conditions, "same location" should mean a terminal or a port basin. We further recommend that IMO consider the preparation of a guidance document to include concepts, criteria, and processes outlining how to identify "same location," which limits should be clearly identified. PMID:23634585

  10. Comparison of canine retraction using single and Siamese edgewise brackets: An in vivo study

    Directory of Open Access Journals (Sweden)

    Zeeshan Iqbal Bhat

    2013-01-01

    Full Text Available Objectives: The purpose of this study was to check the rate of canine retraction with bodily mechanics using two different pre-adjusted edgewise bracket Systems. Materials and Methods: A split mouth study with twenty patients who were randomly selected and allotted to a single operator. Duration of canine retraction, angulation of canine during its retraction, degree of Rotation, anchorage Loss, distance between canine and premolar at different time intervals were then evaluated, pre- (To, 3 months- (T1 and canine tip touches the second premolar- (T2. Descriptive statistics including mean values and standard deviations were calculated. Paired and unpaired t-test was performed to evaluate the differences between the groups. Results: Rotation and angulation of the canines did not show significant difference in both the systems. There was statistically significant difference (P<0.01 in anchorage loss between single wing and Siamese bracket being 2.65 ±1.41 mm and 1.31 ± 0.93 respectively. There was statistically significant intergroup difference (P<0.01 in canine movement i.e distance between canine and premolar was recorded as 4.72mm (15.06 ± 1.69 to 10.34 ± 1.68mm in single wing bracket and 6.25mm in Siamese (15.52 ± 1.41 to 9.27 ± 1.94. Conclusion: In cases where high anchorage is required and the rate of canine retraction is a concern, Siamese brackets pose a definite advantage over Single wing brackets.

  11. Evaluation of cortical bone thickness of mandible with cone beam computed tomography for orthodontic mini implant installation

    Directory of Open Access Journals (Sweden)

    Seyed Hossein Moslemzade

    2014-07-01

    Full Text Available Background: Achieving maximum anchorage without movement of the teeth in anchorage unit has been a great challenge in orthodontics and the success of the treatment plan highly depends on it. In this case, using orthodontic mini-implants can make a huge difference. The objective of this retrospective study was to measure thickness of cortical bone at prospective mini-implant placement sites in mandible in order to understand stability aspects of mini-implant placement by using cone-beam computed tomography (CBCT images.Materials and Methods: Initial 3-dimensional images of 40 adult patients were studied. The cortical bone thickness was obtained at the alveolar processes from canine to second molar at 5 different vertical levels from the cementoenamel junction (CEJ. To determine the cortical bone thickness, tangent lines were drawn buccolingually to the roots in axial section and a third line was drawn from the middle of these two lines, and the cortical bone thickness was measured where the third line crossed the buccal cortex. Results: Mandibular and buccal cortical bone thicknesses were 0.79 to 2.49 mm, respectively. There was a statistically significant increase from the CEJ to the apex (P<0.001, while this increase was not statically significant at interdental area of teeth #3 and #4. Comparing the 4 mm section in all sites showed significant increase from anterior to posterior.Conclusion: Based on our results, the cortical bone thickness mostly follows a pattern and depends on the interradicular site rather than individual differences.  Key words: Cone-beam computed tomography; orthodontic anchorage procedures

  12. The eukaryotic translation elongation factor eEF1A2 induces neoplastic properties and mediates tumorigenic effects of ZNF217 in precursor cells of human ovarian carcinomas

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Yu; Wong, Nicholas; Guan, Yinghui; Salamanca, Clara M.; Cheng, Jung Chien; Lee, Jonathan M.; Gray, Joe W.; Auersperg, Nelly

    2008-04-25

    Ovarian epithelial carcinomas (OEC) frequently exhibit amplifications at the 20q13 locus which is the site of several oncogenes, including the eukaryotic elongation factor EEF1A2 and the transcription factor ZNF217. We reported previously that overexpressed ZNF217 induces neoplastic characteristics in precursor cells of OEC. Unexpectedly, ZNF217, which is a transcriptional repressor, enhanced expression of eEF1A2. In this study, array comparative genomic hybridization, single nucleotide polymorphism and Affymetrix analysis of ZNF217-overexpressing cell lines confirmed consistently increased expression of eEF1A2 but not of other oncogenes, and revealed early changes in EEF1A2 gene copy numbers and increased expression at crisis during immortalization. We defined the influence of eEF1A2 overexpression on immortalized ovarian surface epithelial cells, and investigated interrelationships between effects of ZNF217 and eEF1A2 on cellular phenotypes. Lentivirally induced eEF1A2 overexpression caused delayed crisis, apoptosis resistance and increases in serum-independence, saturation densities, and anchorage independence. siRNA to eEF1A2 reversed apoptosis resistance and reduced anchorage independence in eEF1A2-overexpressing lines. Remarkably, siRNA to eEF1A2 was equally efficient in inhibiting both anchorage independence and resistance to apoptosis conferred by ZNF217 overexpression. Our data define neoplastic properties that are caused by eEF1A2 in nontumorigenic ovarian cancer precursor cells, and suggest that eEF1A2 plays a role in mediating ZNF217-induced neoplastic progression.

  13. Homotypic RANK signaling differentially regulates proliferation, motility and cell survival in osteosarcoma and mammary epithelial cells.

    Science.gov (United States)

    Beristain, Alexander G; Narala, Swami R; Di Grappa, Marco A; Khokha, Rama

    2012-02-15

    RANKL (receptor activator of NF-κB ligand) is a crucial cytokine for regulating diverse biological systems such as innate immunity, bone homeostasis and mammary gland differentiation, operating through activation of its cognate receptor RANK. In these normal physiological processes, RANKL signals through paracrine and/or heterotypic mechanisms where its expression and function is tightly controlled. Numerous pathologies involve RANKL deregulation, such as bone loss, inflammatory diseases and cancer, and aberrant RANK expression has been reported in bone cancer. Here, we investigated the significance of RANK in tumor cells with a particular emphasis on homotypic signaling. We selected RANK-positive mouse osteosarcoma and RANK-negative preosteoblastic MC3T3-E1 cells and subjected them to loss- and gain-of-RANK function analyses. By examining a spectrum of tumorigenic properties, we demonstrate that RANK homotypic signaling has a negligible effect on cell proliferation, but promotes cell motility and anchorage-independent growth of osteosarcoma cells and preosteoblasts. By contrast, establishment of RANK signaling in non-tumorigenic mammary epithelial NMuMG cells promotes their proliferation and anchorage-independent growth, but not motility. Furthermore, RANK activation initiates multiple signaling pathways beyond its canonical target, NF-κB. Among these, biochemical inhibition reveals that Erk1/2 is dominant and crucial for the promotion of anchorage-independent survival and invasion of osteoblastic cells, as well as the proliferation of mammary epithelial cells. Thus, RANK signaling functionally contributes to key tumorigenic properties through a cell-autonomous homotypic mechanism. These data also identify the likely inherent differences between epithelial and mesenchymal cell responsiveness to RANK activation. PMID:22421365

  14. Three-dimensional evaluation of upper anterior alveolar bone dehiscence after incisor retraction and intrusion in adult patients with bimaxillary protrusion malocclusion

    Institute of Scientific and Technical Information of China (English)

    Qing-yuan GUO; Shi-jie ZHANG; Hong LIU; Chun-ling WANG; Fu-lan WEI; Tao LV; Na-na WANG; Dong-xu LIU

    2011-01-01

    Objective: The purpose of this study was to evaluate three-dimensional (3D) dehiscence of upper anterior alveolar bone during incisor retraction and intrusion in adult patients with maximum anchorage.Methods: Twenty adult patients with bimaxillary dentoalveolar protrusion had the four first premolars extracted.Miniscrews were placed to provide maximum anchorage for upper incisor retraction and intrusion.A computed tomography (CT) scan was performed after placement of the miniscrews and treatment.The 3D reconstructions of pre- and post-CT data were used to assess the dehiscence of upper anterior alveolar bone.Results: The amounts of upper incisor retraction at the edge and apex were (7.64±1.68) and (3.91±2.10) mm,respectively,and (1.34±0.74) mm of upper central incisor intrusion.Upper alveolar bone height losses at labial alveolar ridge crest (LAC) and palatal alveolar ridge crest (PAC) were 0.543 and 2.612 mm,respectively,and the percentages were (6.49±3.54)% and (27.42±9.77)%,respectively.The shape deformations of LAC-labial cortex bending point (LBP) and PAC-palatal cortex bending point (PBP) were (15.37±5.20)° and (6.43±3.27)°,respectively.Conclusions: Thus,for adult patients with bimaxillary protrusion,mechanobiological response of anterior alveolus should be taken into account during incisor retraction and intrusion.Pursuit of maximum anchorage might lead to upper anterior alveolar bone loss.

  15. The role of Rac1 in the regulation of NF-kB activity, cell proliferation, and cell migration in non-small cell lung carcinoma

    Science.gov (United States)

    Gastonguay, Adam; Berg, Tracy; Hauser, Andrew D.; Schuld, Nathan; Lorimer, Ellen; Williams, Carol L.

    2012-01-01

    The small GTPase Rac1 regulates many cellular processes, including cytoskeletal reorganization, cell migration, proliferation, and survival. Additionally, Rac1 plays a major role in activating NF-κB-mediated transcription. Both Rac1 and NF-κB regulate many properties of the malignant phenotype, including anchorage-independent proliferation and survival, metastasis, and angiogenesis. Despite these findings, the roles of Rac1and NF-κB in non-small cell lung carcinoma, a leading cause of cancer deaths, have not been thoroughly investigated. Here, we compared the effects of Rac1 siRNA to that of the Rac1 inhibitor NSC23766 on multiple features of the NSCLC malignant phenotype, including NF-κB activity. We show that the siRNA-mediated silencing of Rac1 in lung cancer cells results in decreased cell proliferation and migration. The decrease in proliferation was observed in both anchorage-dependent and anchorage-independent assays. Furthermore, cells with decreased Rac1 expression have a slowed progression through the G1 phase of the cell cycle. These effects induced by Rac1 siRNA correlated with a decrease in NF-κB transcriptional activity. Additionally, inhibition of NF-κB signaling with BAY 11–7082 inhibited proliferation; indicating that the loss of cell proliferation and migration induced by the silencing of Rac1 expression may be attributed in part to loss of NF-κB activity. Interestingly, treatment with the Rac1 inhibitor NSC23766 strongly inhibits cell proliferation, cell cycle progression, and NF-κB activity in lung cancer cells, to an even greater extent than the inhibition induced by Rac1 siRNA. These findings indicate that Rac1 plays an important role in lung cancer cell proliferation and migration, most likely through its ability to promote NF-κB activity, and highlight Rac1 pathways as therapeutic targets for the treatment of lung cancer. PMID:22549160

  16. Effect of prostaglandin E1 versus corticotomy on orthodontic tooth movement: An in vivo study

    OpenAIRE

    U B Rajasekaran; U S Krishna Nayak

    2014-01-01

    Background and Aim: The aim of the present study is to compare the effect of corticotomy versus prostaglandin E1 injection in human subjects on rate of tooth movement, anchorage loss and their effect on crest bone height and root length. Settings and Design: Clinical interventional study. Split mouth design was used. Materials and Methods: Study was done on 32 regular orthodontic patients. A volume of 100 mcg of prostaglandin E1 was injected on the right side once in 2 weeks and on th...

  17. Continuous torque system with control of the reaction unit.

    Science.gov (United States)

    Gandini, Luiz Gonzaga; Gandini, Márcia Regina Elisa Aparecida Schiavon; Amaral, Roberta Maria de Paula

    2010-03-01

    This article describes an orthodontic system used to obtain active continuous torque with movement control of both active and reactive units; the system relies on principles of the segmented technique. A cantilever system with .017 x .025-in beta-titanium alloy wire was designed to provide the desirable moment on the active unit. A transpalatal bar or a lingual arch increases the anchorage and neutralizes the side effects on the reactive unit. This technique is an efficient approach for major corrections of buccolingual inclinations of certain teeth. PMID:20197179

  18. New techniques in dental surgical CT

    International Nuclear Information System (INIS)

    This paper demonstrates how CT can be used with dental software to evaluate prosthetic failure and for planning dental implants when a stent is used. The Food and Drug Administration issued a safety alert for proplast-coated temporomandibular joint prostheses. Prosthetic failure occurs with migration, fragmentation, or bone erosion. Sagittal CT requiring a special head holder can instead be performed with reformatted sagittal images. The technique of dental implant CT changes when a dental stent is used to provide more accurate implant anchorage and planning. Images must be parallel to the occlusal plane. We will demonstrate these techniques and present their rationale

  19. [Experience with surgical-orthodontic management of impacted and retained upper canines].

    Science.gov (United States)

    Herényi, G

    1990-07-01

    On basis of experiences obtained in the course of the surgical orthodontic treatment of 26 upper impacted and retained, respectively, incisors it has been established that, at given conditions, positioning the incisor into occlusion should be tried, even if the axis position approaches 90 degrees. The lesion is discovered relatively lately, many do not risk the treatment and the number of interrupted treatments is high as well. There is possibility to avoid possible complications, interruption of joining to force system, loss of anchorage, pulpa necrosis, root resorption, cysta follicularis. PMID:2390994

  20. Proton precipitation by a whistler-mode wave from a VLF transmitter

    International Nuclear Information System (INIS)

    Protons with 50 keV< E<530 keV were detected by sensors aboard satellite 1972-76B at an altitude of 700 km in the region conjugate to the transportable very-low-frequency (TVLF) transmitter which was being operated near Anchorage, Alaska Lapprox.4). Temporal maxima in the proton count rates can be identified on a one-to-one basis with short pulsed transmissions by the VLF transmitter. The observed time delay between the center of a transmitted pulse and the detection of the next maximum in the proton count rate at the sensor agrees well with the delay predicted from a simple plasmaspheric model. (auth)

  1. Three-dimensional mammalian cell growth on nonwoven polyester fabric disks.

    Science.gov (United States)

    Petti, S A; Lages, A C; Sussman, M V

    1994-01-01

    Small disks of nonwoven polyester fabric (NWPF), similar to Fibra-Cel carriers, were surface treated with strong acid and used as a high surface area support matrix for in vitro culture of anchorage dependent MRC-5 cells. The disks can be autoclaved, and require inocula concentrations of only 2-5% of the final cell densities, which have reached 10(8) cells/mL of disk bed volume. Scanning electron microscopy photographs shown herein reveal that cells grow in a multilayered fashion between the randomly arrayed fibers of the nonwoven fabric, emulating in vivo growth. PMID:7522468

  2. Korean Air Excellence in Flight

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ Korean Air with a fleet of 119 aircraft, is one of the world's top 20 airlines, and oper-ates almost 400 flights everyday to 90 cities in 33 countries. The airline has about 50 flights per week between the US and Asia from nine US gateways: New York, Los Angeles, Washington,Chicago, Dallas, San Francisco, Atlanta, Anchorage and Honolulu.The carrier is a founding member of SkyTeam, the global airline alliance partnering AeroMexico, Air France, Alitalia, CSA Czech Airlines, Continental Airlines, Delta Air Lines, KLM and Northwest Airlines to provide customers with extensive worldwide destina-tions, flights and services.

  3. The extension of the 7{sup th} level south shaft-landing, 10 shaft, Prosper Haniel colliery; Weiterauffahrung des suedlichen Fuellortes Schacht 10, 7. Sohle auf dem Bergwerk Prosper-Haniel

    Energy Technology Data Exchange (ETDEWEB)

    Luettig, Frank [RAG Aktiengesellschaft, Herne (Germany). BT-D Bergtechnik, Ausbau, Streckenplanung; Schlueter, Hartmut; Barth, Ulrich [Bergwerk Prosper-Haniel, Bottrop (Germany)

    2010-11-15

    During the further sinking of shaft 10 the landing on the 7{sup th} level was bilaterally discontinued for approx. 10 m. In September 2008, with the drifting of the lateral C467 the interconnection was effected at the northern landing. For that interconnection a numerical model was created in advance so as to assess the influence of the drifting on the very stiff support casing of the landing (steel-fibre-reinforced shotcrete with reticulate supports and anchorage). A detailed scheme of the individual drifting steps was elaborated based on the calculation results and the present geological/geotechnical situation, and the planned scheme was subsequently implemented with success in underground operations.

  4. FRP-to-concrete joint assemblies anchored with multiple FRP anchors: experimental investigation

    OpenAIRE

    Zhang, H.; Smith, ST

    2010-01-01

    Higher strains can be developed in fibre-reinforced polymer (FRP) composites which are bonded to the surfaces of concrete members if the FRP is anchored. Anchors made from FRP (also known as FRP spike anchors but herein referred to as FRP anchors) are a promising type of anchorage as they can be applied to a variety of different shaped structural elements and they have been shown to be effective in en-hancing the strain capacity of externally bonded FRP. Limited research, however, has been co...

  5. Biomechanics in Dentistry Evaluation of Different Surgical Approaches to Treat Atrophic Maxilla Patients

    CERN Document Server

    Ishak, Muhammad Ikman

    2013-01-01

    This book shows computational finite element simulations to analyse the strength of implant anchorage for intrasinus and extramaxillary approaches under various occlusal loading locations and directions. Three-dimensional model of the craniofacial area surrounding the region of interest, soft tissue and framework are developed using computed tomography image datasets.  The zygomatic and standard dental implants are modeled using a conventional computer-aided design software and placed at the appropriate location.  Material properties are assigned appropriately for the cortical, cancellous bones and implants with Masseter forces applied at the zygomatic arch and occlusal loadings applied on the framework surface.

  6. Activities of seismic safety enhancement on equipments and components in Kashiwazaki Kariwa Nuclear Power Station

    International Nuclear Information System (INIS)

    This article introduced seismic safety enhancement measures and upgrade of seismic evaluation methods on equipments and components in Kashiwazaki Kariwa Nuclear Power Station. Reinforcement works for seismic safety against the earthquake of 1000 gal at the bed rock of reactor building had been made on pipe support structure, fuel handling machine and ceiling mounted crane of reactor building using upgraded seismic response analysis. As for upgrade of seismic evaluation methods, hysteresis characteristics of reactor base structure and seismic affected fatigue of piping had been evaluated as well as forced vibration test of component base anchorage zone and underwater vibration test of spent fuel storage rack to obtain damping constant. (T. Tanaka)

  7. Guidelines for evaluation of non-Safety Class 1 structural components having effects on Safety Class 1 equipment

    International Nuclear Information System (INIS)

    Non-Safety Class 1 piping, vessels, and equipment require substantial seismic evaluation to ensure that failure during an earthquake does not result in Safety Class 1 equipment pressure boundary failure, distortion, or loss of function. Design analysis guidelines for non-Safety Class 1 equipment are presented that address applied loads, seismic inertia loads, and damping values. Approaches to evaluating existing equipment anchorage, anchor bolt allowables, piping contributory masses for support evaluation, and proposed allowable stresses are discussed in this paper. Proposed allowables are developed for piping, electrical conduit, and heating and ventilation ducting. Applications of the guidelines to nuclear reactor and nuclear facilities are discussed

  8. Introducing a Method of In Vitro Testing of Different Anchoring Systems Used for Female Incontinence and Prolapse Surgery

    OpenAIRE

    Ralf Anding; Ruth Tabaza; Manfred Staat; Eva Trenz; Philipp Lohmann; Uwe Klinge; Ruth Kirschner-Hermanns

    2013-01-01

    Aims. To develop a method for in vitro testing to compare different intracorporeal anchoring systems (AS) used, for example, in single-incision slings or vaginal meshes. Intracorporeal fixation needs reliable anchorage systems, which keep the implant in the operative and early postoperative phase in place. Up to now, the impact of the design of current anchor systems and their capability to provide sufficient retention forces is not known. Methods. Four AS (“PelFix”, “Surelift”, “TFS”, and “M...

  9. Inhibitory Role of α6β4-Associated Erbb-2 and Phosphoinositide 3-Kinase in Keratinocyte Haptotactic Migration Dependent on α3β1 Integrin

    OpenAIRE

    Hintermann, Edith; Bilban, Martin; Sharabi, Andrew; Quaranta, Vito

    2001-01-01

    Keratinocytes and other epithelial cells express two receptors for the basement membrane (BM) extracellular matrix component laminin-5 (Ln-5), integrins α3β1 and α6β4. While α3β1 mediates adhesion, spreading, and migration (Kreidberg, J.A. 2000. Curr. Opin. Cell Biol. 12:548–553), α6β4 is involved in BM anchorage via hemidesmosomes (Borradori, L., and A. Sonnenberg. 1999. J. Invest. Dermatol. 112:411–418). We investigated a possible regulatory interplay between α3β1 and α6β4 in cell motility ...

  10. Fast Dependency-Aware Feature Selection in Very-High-Dimensional Pattern Recognition

    Czech Academy of Sciences Publication Activity Database

    Somol, Petr; Grim, Jiří; Pudil, P.

    Piscataway: IEEE, 2011, s. 502-509. ISBN 978-1-4577-0653-0. [The 2011 IEEE International Conference on Systems, Man, and Cybernetics (IEEE SMC 2011). Anchorage, Alaska (US), 09.10.2011-12.10.2011] R&D Projects: GA MŠk 1M0572 Grant ostatní: GA MŠk(CZ) 2C06019 Institutional research plan: CEZ:AV0Z10750506 Keywords : feature selection * high dimensionality * ranking * classification * machine learning Subject RIV: IN - Informatics, Computer Science http://library.utia.cas.cz/separaty/2011/RO/somol-fast dependency-aware feature selection in very-high-dimensional pattern recognition-c.pdf

  11. Transversely Compressed Bonded Joints

    DEFF Research Database (Denmark)

    Hansen, Christian Skodborg; Schmidt, Jacob Wittrup; Stang, Henrik

    2012-01-01

    The load capacity of bonded joints can be increased if transverse pressure is applied at the interface. The transverse pressure is assumed to introduce a Coulomb-friction contribution to the cohesive law for the interface. Response and load capacity for a bonded single-lap joint was derived using...... non-linear fracture mechanics. The results indicated a good correlation between theory and tests. Furthermore, the model is suggested as theoretical base for determining load capacity of bonded anchorages with transverse pressure, in externally reinforced concrete structures....

  12. Mini-screws, a viable adjunct along with Incognito lingual appliance: A case series

    Directory of Open Access Journals (Sweden)

    Wei Lin

    2015-01-01

    Full Text Available Invisible orthodontics have been around for too long, and with the advent of computer-aided design/computer-aided manufacturing technology appliances such as Incognito TM has made the whole treatment experience more pleasant and aesthetic. However, even in lingual orthodontics, biomechanics play the most important role, and the use of temporary anchorage devices (TADs has made the whole treatment more effective and efficient. This article focuses on cases where TADs in lingual appliances play a critical role in the treatment of various malocclusions.

  13. Assessment of rock bolt systems for underground waste storage

    International Nuclear Information System (INIS)

    A review of existing rock bolting systems was undertaken to assess their suitability in underground design for storage of nuclear waste. Unique engineering considerations are required due to the thermal pulse generated by the waste causing additional stress to the support system and possibly affecting anchorage stability. Field visits were made to four underground projects to assess the performance of a wide variety of rock bolt systems. Cable bolts, point anchor bolts, locally debonded full column cement grout bolts, and yieldable bolt systems show promise. Full scale testing of bolt systems is recommended, together with assessing temperature effects on grout strength and grout longterm stability

  14. Civic Cohesion, and Sanctuaries for Coming to Terms with Modernity

    DEFF Research Database (Denmark)

    Greve, Anni

    2006-01-01

    The city is a key location of the modern social world, a home of rootlessness and transient everyday encounters between individuals. This essay explores the idea of 'the sanctuary' as a way in which people look for anchorage, and create and re-create images of a society, to cope with and negotiate...... Durkheim sees ritual -especially sacred drama - as at once a symbolism and an aesthetics, complete with the energies of a free creative 'surplus'. Even if in the end 'the sanctuary' is unequal to the marketplace, it is a necessary refuge of the transformative social imagination and a realm, not of everyday...

  15. REG Iα gene expression is linked with the poor prognosis of lung adenocarcinoma and squamous cell carcinoma patients via discrete mechanisms

    OpenAIRE

    KIMURA, MICHITAKA; NAITO, HIROSHI; Tojo, Takashi; ITAYA-HIRONAKA, ASAKO; Dohi, Yoshiko; YOSHIMURA, MAMIKO; NAKAGAWARA, KAN-ICHI; Takasawa, Shin; Taniguchi, Shigeki

    2013-01-01

    The aim of the present study was to evaluate the effects of the REG Iα and REG Iβ genes on lung cancer cell lines, and thereafter, the expression of REG family genes (REG Iα, REG Iβ, REG III, HIP/PAP and REG IV) in lung cancer in relation to patient prognosis was evaluated. Lung adenocarcinoma (AD) and squamous cell carcinoma (SCC) cell lines expressing REG Iα or REG Iβ (HLC-1 REG Iα/Iβ and EBC-1 REG Iα/Iβ) were established, and cell number, cell invasive activity, and anchorage-independent c...

  16. Managerial Spirit from de Social Representations: Venezuelan case

    Directory of Open Access Journals (Sweden)

    Leslie Borjas de Xena

    2010-11-01

    Full Text Available This research seeks to characterize the central and peripheral structures of the Social Representations (SR on Entrepreneurial Spirit (ES. The SR are ways of social thinking that include information, beliefs, attitudes, practices and experiences. This type of research is complementary. The methodology called for the analysis of content found in secondary literature and in depth interviews. The corpus includes 65 articles in the 2006-2009 period. The results showed that the anchorage of the SR in the Venezuelan context could be characterized as “highly” entrepreneur

  17. Is traditional treatment a good option for an adult with a Class II deepbite malocclusion?

    Science.gov (United States)

    Abdo Quintão, Catia Cardoso; Miguel, Jose Augusto Mendes; Brunharo, Ione Portela; Zanardi, Gustavo; Feu, Daniela

    2012-01-01

    The Tweed-Merrifield directional force technique is a useful treatment approach for a patient with a Class II malocclusion with dentoalveolar protrusion. The purpose of this case report was to present the diagnosis and treatment descriptions of a patient with an Angle Class II malocclusion complicated by tooth losses, severe dentoalveolar protrusion, and skeletal discrepancy. Treatment involved extraction of the maxillary first premolars, high-pull headgear to enhance anchorage, and high-pull J-hook headgear to retract and intrude the maxillary anterior segments. A successful outcome was achieved with traditional orthodontic treatment in this borderline surgical case. PMID:22196191

  18. Marine spill response planning for the non-persistent oil transportation industry in Alaska

    International Nuclear Information System (INIS)

    The unique difficulties that face oil spill response planning for the oil transportation industry in Alaska were discussed. Three levels of response strategies and actions proposed by the Alaska Petroleum Distributors and Transporters (APD and T) member companies were reviewed. They were: (1) immediate response (on-board resources), (2) in-region response (caches in Subareas), and (3) out-of-region cascaded resources (from Anchorage and other sources). The strategies and levels of capability were proposed as emergency measures in addition to the more important prevention measures already instituted to prevent discharges of non-persistent oil. 5 refs., 2 tabs., 9 figs

  19. Multilayer radar absorbing material processing by using polymeric nonwoven and conducting polymer

    Directory of Open Access Journals (Sweden)

    Luiza de Castro Folgueras

    2008-09-01

    Full Text Available This study shows the processing of radar absorbing multilayer structures based on nonwoven substrates of polyacrylonitrile and poly (ethylene terephthalate impregnated with a polyaniline and polyurethane mixture. Processed materials with different parameters - layer stacking and impregnated faces - were evaluated considering the incident radiation attenuation in the frequency range of 8 to 12 GHz. The results show the influence of the quantity, types and thickness of the impregnated layers. Scanning electronic microscopy observations evaluated the anchorage of the absorbing center (polyaniline in the substrate. In a general way, the different obtained structures presented incident radiation attenuation values between 87 and 99%. This result allows its use as microwave absorbers.

  20. HPV vaccines for circumpolar health: summary of plenary session, “Opportunities for Prevention: Global HPV Vaccine” and “Human Papillomavirus Prevention: The Nordic Experience”

    OpenAIRE

    Dunne, Eileen F; Koch, Anders

    2013-01-01

    In this publication, we provide an overview of the presentations, ‘‘Opportunities for Prevention: Global HPV Vaccine’’ and ‘‘Human Papillomavirus Prevention: The Nordic Experience’’ as a part of the 15th International Congress on Circumpolar Health, held at Anchorage, Alaska, on August 8, 2012. We provide an overview of HPV, HPV vaccines and policy as well as the Nordic experience with HPV vaccine introduction.Keywords: HPV vaccine; Nordic countries; circumpolar health; HPV(Published: 5 Augus...