WorldWideScience

Sample records for anchor walls

  1. The Analysis Stability of Anchor Retaining Wall

    International Nuclear Information System (INIS)

    The construction of anchored retaining walls reach every day in the field of Civil Engineering especially in public works. Their dimensioning and stability are the axes of research for geotechnical. The rule is to reduce the active forces of the slide and increase the effective normal stress on the rupture surface. So that, we anchored tied-back (constituted by steel cables) in the stable ground located under the failure surface and we apply at the top a traction force. This effort can be distributed over the ground surface by means of small plates or massive reinforced concrete. The study of the stability of anchored retaining wall was also performed by using software GEO4. Many cases can be solved using analytical solutions available in the group GEO4 program, but for our standard model solution studied analytically proved unsatisfactory so we used a numerical analysis based on the method of finite element in this program. The results obtained by numerical study were interpreted to identify the precision numerical predictions. Moreover these methods were useful and economics in the realization of reinforced slopes by tied-buck. (author)

  2. Considerations on the design of through-wall anchors

    International Nuclear Information System (INIS)

    Connections to existing buildings are often the most difficult planning challenge for the realization of construction measures in case of piping system replacements in nuclear power plants. This is due to restricted space or limited load reserves of the building structure. Usually the realization of support connections to the existing buildings is achieved by anchor bolts. But in critical cases the preferred alternative solution uses through-wall anchors. Up to now uniform assessment thresholds are not available, no technical guidelines or regulations for construction variants exist. Through-wall anchors allow significantly higher load capacities for tensile and shear loads but require enhanced planning and realization efforts.

  3. Field Behavior of A High Anchored Reinforced Earth Wall

    Directory of Open Access Journals (Sweden)

    Faisal H. Ali

    2008-01-01

    Full Text Available Since the invention of Reinforced Earth by the French architect Hendri Vidal in 1966, numerous reinforced soil walls have been designed and constructed all over the world. In this study the focus was on a particular type of reinforced wall called Nehemiah wall which differed from the Vidal type in the sense that instead of steel strips, the reinforcing elements consisted of steel bars with anchor blocks attached at the free ends. A full scale high anchored reinforced earth wall was constructed and instrumented to capture the essential behavior of the wall. Two sections of the wall were monitored where at one of the sections polystyrene foam was inserted at the back face of the wall panel to allow for lateral deformation to take place which means that the facing was less flexible in the transverse direction. The lateral deformation, axial forces along the reinforcing bars and settlement were monitored and measured for both cases and the results were compared and discussed.

  4. Physical and numerical modelling of earth pressure on anchored sheet pile walls in sand

    DEFF Research Database (Denmark)

    Krogsbøll, Anette Susanne; Fuglsang, Leif D

    The influence of wall flexibility on earth pressure, bending moments and failure modes is studied. Numerical models are compared to results from model tests carried out in a geotechnical centrifuge. The back-fill is dry sand and failure is introduced by allowing the wall to rotate around the anchor......-model showed the right behaviour in pre-failure as well as failure for both flexible and stiff walls, whereas the MC-model showed some shortcomings when stiff walls were modelled....

  5. Cell wall antibiotics provoke accumulation of anchored mCherry in the cross wall of Staphylococcus aureus.

    Directory of Open Access Journals (Sweden)

    Wenqi Yu

    Full Text Available A fluorescence microscopy method to directly follow the localization of defined proteins in Staphylococcus was hampered by the unstable fluorescence of fluorescent proteins. Here, we constructed plasmid (pCX encoded red fluorescence (RF mCherry (mCh hybrids, namely mCh-cyto (no signal peptide and no sorting sequence, mCh-sec (with signal peptide, and mCh-cw (with signal peptide and cell wall sorting sequence. The S. aureus clones targeted mCh-fusion proteins into the cytosol, the supernatant and the cell envelope respectively; in all cases mCherry exhibited bright fluorescence. In staphylococci two types of signal peptides (SP can be distinguished: the +YSIRK motif SP(lip and the -YSIRK motif SP(sasF. mCh-hybrids supplied with the +YSIRK motif SP(lip were always expressed higher than those with -YSIRK motif SP(sasF. To study the location of the anchoring process and also the influence of SP type, mCh-cw was supplied on the one hand with +YSIRK motif (mCh-cw1 and the other hand with -YSIRK motif (mCh-cw2. MCh-cw1 preferentially localized at the cross wall, while mCh-cw2 preferentially localized at the peripheral wall. Interestingly, when treated with sub-lethal concentrations of penicillin or moenomycin, both mCh-cw1 and mCh-cw2 were concentrated at the cross wall. The shift from the peripheral wall to the cross wall required Sortase A (SrtA, as in the srtA mutant this effect was blunted. The effect is most likely due to antibiotic mediated increase of free anchoring sites (Lipid II at the cross wall, the substrate of SrtA, leading to a preferential incorporation of anchored proteins at the cross wall.

  6. Anchor reinforcements

    Energy Technology Data Exchange (ETDEWEB)

    Levkovich, P.Ye.; Sal' nikov, V.K.; Savich, N.S.

    1980-11-30

    An anchor reinforcement includes an anchor shaft, an elastic jig with a separator wall having compartments placed parallely along it and filled with reinforcement material and a device for destroying the jig wall separator. To quickly put the anchor in place and increase the reliability of the reinforcement by mixing the reinforcement material components better, the device for destroying the jig separator wall was made in the shape of a shovel, fastened to the anchor shaft and the separator wall has a longitudinal hollow for holding the anchor shaft/shovel.

  7. Restrictive glycosylphosphatidylinositol anchor synthesis in cwh6/gpi3 yeast cells causes aberrant biogenesis of cell wall proteins.

    OpenAIRE

    Vossen, J.H.; Müller, W. H.; Lipke, P N; Klis, F. M.

    1997-01-01

    We previously reported that the defects in the Saccharomyces cerevisiae cwh6 Calcofluor white-hypersensitive cell wall mutant are caused by a mutation in SPT14/GPI3, a gene involved in glycosylphosphatidylinositol (GPI) anchor biosynthesis. Here we describe the effect of cwh6/spt14/gpi3 on the biogenesis of cell wall proteins. It was found that the release of precursors of cell wall proteins from the endoplasmic reticulum (ER) was retarded. This was accompanied by proliferation of ER structur...

  8. Study of Individual Characteristic Abdominal Wall Thickness Based on Magnetic Anchored Surgical Instruments

    Directory of Open Access Journals (Sweden)

    Ding-Hui Dong

    2015-01-01

    Full Text Available Background: Magnetic anchored surgical instruments (MASI, relying on magnetic force, can break through the limitations of the single port approach in dexterity. Individual characteristic abdominal wall thickness (ICAWT deeply influences magnetic force that determines the safety of MASI. The purpose of this study was to research the abdominal wall characteristics in MASI applied environment to find ICAWT, and then construct an artful method to predict ICAWT, resulting in better safety and feasibility for MASI. Methods: For MASI, ICAWT is referred to the thickness of thickest point in the applied environment. We determined ICAWT through finding the thickest point in computed tomography scans. We also investigated the traits of abdominal wall thickness to discover the factor that can be used to predict ICAWT. Results: Abdominal wall at C point in the middle third lumbar vertebra plane (L3 is the thickest during chosen points. Fat layer thickness plays a more important role in abdominal wall thickness than muscle layer thickness. "BMI-ICAWT" curve was obtained based on abdominal wall thickness of C point in L3 plane, and the expression was as follow: f(x = P1 × x 2 + P2 × x + P3, where P1 = 0.03916 (0.01776, 0.06056, P2 = 1.098 (0.03197, 2.164, P3 = −18.52 (−31.64, −5.412, R-square: 0.99. Conclusions: Abdominal wall thickness of C point at L3 could be regarded as ICAWT. BMI could be a reliable predictor of ICAWT. In the light of "BMI-ICAWT" curve, we may conveniently predict ICAWT by BMI, resulting a better safety and feasibility for MASI.

  9. Automatic Thickness and Volume Estimation of Sprayed Concrete on Anchored Retaining Walls from Terrestrial LIDAR Data

    Science.gov (United States)

    Martínez-Sánchez, J.; Puente, I.; GonzálezJorge, H.; Riveiro, B.; Arias, P.

    2016-06-01

    When ground conditions are weak, particularly in free formed tunnel linings or retaining walls, sprayed concrete can be applied on the exposed surfaces immediately after excavation for shotcreting rock outcrops. In these situations, shotcrete is normally applied conjointly with rock bolts and mesh, thereby supporting the loose material that causes many of the small ground falls. On the other hand, contractors want to determine the thickness and volume of sprayed concrete for both technical and economic reasons: to guarantee their structural strength but also, to not deliver excess material that they will not be paid for. In this paper, we first introduce a terrestrial LiDAR-based method for the automatic detection of rock bolts, as typically used in anchored retaining walls. These ground support elements are segmented based on their geometry and they will serve as control points for the co-registration of two successive scans, before and after shotcreting. Then we compare both point clouds to estimate the sprayed concrete thickness and the expending volume on the wall. This novel methodology is demonstrated on repeated scan data from a retaining wall in the city of Vigo (Spain), resulting in a rock bolts detection rate of 91%, that permits to obtain a detailed information of the thickness and calculate a total volume of 3597 litres of concrete. These results have verified the effectiveness of the developed approach by increasing productivity and improving previous empirical proposals for real time thickness estimation.

  10. Sortase A substrate specificity in GBS pilus 2a cell wall anchoring.

    Directory of Open Access Journals (Sweden)

    Francesca Necchi

    Full Text Available Streptococcus agalactiae, also referred to as Group B Streptococcus (GBS, is one of the most common causes of life-threatening bacterial infections in infants. In recent years cell surface pili have been identified in several Gram-positive bacteria, including GBS, as important virulence factors and promising vaccine candidates. In GBS, three structurally distinct types of pili have been discovered (pilus 1, 2a and 2b, whose structural subunits are assembled in high-molecular weight polymers by specific class C sortases. In addition, the highly conserved housekeeping sortase A (SrtA, whose main role is to link surface proteins to bacterial cell wall peptidoglycan by a transpeptidation reaction, is also involved in pili cell wall anchoring in many bacteria. Through in vivo mutagenesis, we demonstrate that the LPXTG sorting signal of the minor ancillary protein (AP2 is essential for pilus 2a anchoring. We successfully produced a highly purified recombinant SrtA (SrtA(ΔN40 able to specifically hydrolyze the sorting signal of pilus 2a minor ancillary protein (AP2-2a and catalyze in vitro the transpeptidation reaction between peptidoglycan analogues and the LPXTG motif, using both synthetic fluorescent peptides and recombinant proteins. By contrast, SrtA(ΔN40 does not catalyze the transpeptidation reaction with substrate-peptides mimicking sorting signals of the other pilus 2a subunits (the backbone protein and the major ancillary protein. Thus, our results add further insight into the proposed model of GBS pilus 2a assembly, in which SrtA is required for pili cell wall covalent attachment, acting exclusively on the minor accessory pilin, representing the terminal subunit located at the base of the pilus.

  11. Comparison of cell wall proteins of Saccharomyces cerevisiae as anchors for cell surface expression of heterologous proteins.

    OpenAIRE

    van der Vaart, J. M.; te Biesebeke, R; Chapman, J.W.; Toschka, H Y; Klis, F M; Verrips, C. T.

    1997-01-01

    The carboxyl-terminal regions of five cell wall proteins (Cwp1p, Cwp2p, Ag alpha 1p, Tip1p, and Flo1p) and three potential cell wall proteins (Sed1p, YCR89w, and Tir1p) all proved capable of immobilizing alpha-galactosidase in the cell wall of Saccharomyces cerevisiae. The fraction of the total amount of fusion protein that was localized to the cell wall varied depending on the anchor domain used. The highest proportion of cell wall incorporation was achieved with Cwp2p, Ag alpha 1p, or Sed1p...

  12. The role of Listeria monocytogenes cell wall surface anchor protein LapB in virulence, adherence, and intracellular replication

    Science.gov (United States)

    Lmof2365_2117 is a Listeria monocytogenes putative cell wall surface anchor protein with a conserved domain found in collagen binding proteins. We constructed a deletion mutation in lmof2365_2117 in serotype 4b strain F2365, evaluated its virulence, and determined its ability to adhere and invade co...

  13. Characterisation of a cell wall-anchored protein of Staphylococcus saprophyticus associated with linoleic acid resistance

    Directory of Open Access Journals (Sweden)

    King Nathan P

    2012-01-01

    Full Text Available Abstract Background The Gram-positive bacterium Staphylococcus saprophyticus is the second most frequent causative agent of community-acquired urinary tract infections (UTI, accounting for up to 20% of cases. A common feature of staphylococci is colonisation of the human skin. This involves survival against innate immune defenses including antibacterial unsaturated free fatty acids such as linoleic acid which act by disrupting bacterial cell membranes. Indeed, S. saprophyticus UTI is usually preceded by perineal skin colonisation. Results In this study we identified a previously undescribed 73.5 kDa cell wall-anchored protein of S. saprophyticus, encoded on plasmid pSSAP2 of strain MS1146, which we termed S. saprophyticus surface protein F (SssF. The sssF gene is highly prevalent in S. saprophyticus clinical isolates and we demonstrate that the SssF protein is expressed at the cell surface. However, unlike all other characterised cell wall-anchored proteins of S. saprophyticus, we were unable to demonstrate a role for SssF in adhesion. SssF shares moderate sequence identity to a surface protein of Staphylococcus aureus (SasF recently shown to be an important mediator of linoleic acid resistance. Using a heterologous complementation approach in a S. aureus sasF null genetic background, we demonstrate that SssF is associated with resistance to linoleic acid. We also show that S. saprophyticus strains lacking sssF are more sensitive to linoleic acid than those that possess it. Every staphylococcal genome sequenced to date encodes SssF and SasF homologues. Proteins in this family share similar predicted secondary structures consisting almost exclusively of α-helices in a probable coiled-coil formation. Conclusions Our data indicate that SssF is a newly described and highly prevalent surface-localised protein of S. saprophyticus that contributes to resistance against the antibacterial effects of linoleic acid. SssF is a member of a protein family

  14. Domain Walls and Anchoring Transitions Mimicking Nematic Biaxiality in the Oxadiazole Bent-Core Liquid Crystal C7

    OpenAIRE

    Kim, Young-Ki; Cukrov, Greta; Xiang, Jie; Shin, Sung-Tae; Lavrentovich, Oleg D.

    2015-01-01

    We investigate the origin of secondary disclinations that were recently described as a new evidence of a biaxial nematic phase in an oxadiazole bent-core thermotropic liquid crystal C7. With an assortment of optical techniques such as polarizing optical microscopy, LC PolScope, and fluorescence confocal polarizing microscopy, we demonstrate that the secondary disclinations represent non-singular domain walls formed in an uniaxial nematic during the surface anchoring transition, in which surfa...

  15. Comparison of cell wall proteins of Saccharomyces cerevisiae as anchors for cell surface expression of heterologous proteins.

    Science.gov (United States)

    Van der Vaart, J M; te Biesebeke, R; Chapman, J W; Toschka, H Y; Klis, F M; Verrips, C T

    1997-01-01

    The carboxyl-terminal regions of five cell wall proteins (Cwp1p, Cwp2p, Ag alpha 1p, Tip1p, and Flo1p) and three potential cell wall proteins (Sed1p, YCR89w, and Tir1p) all proved capable of immobilizing alpha-galactosidase in the cell wall of Saccharomyces cerevisiae. The fraction of the total amount of fusion protein that was localized to the cell wall varied depending on the anchor domain used. The highest proportion of cell wall incorporation was achieved with Cwp2p, Ag alpha 1p, or Sed1p as an anchor. Although 80% of these fusion proteins were incorporated in the cell wall, the total production of alpha-galactosidase-Ag alpha 1p was sixfold lower than that of alpha-galactosidase-Cwp2p and eightfold lower than that of alpha-galactosidase-Sed1p. Differences in mRNA levels were not responsible for this discrepancy, nor was an intracellular accumulation of alpha-galactosidase-Ag alpha 1p detectable. A lower translation efficiency of the alpha-galactosidase-AG alpha 1 fusion construct is most likely to be responsible for the low level of protein production. alpha-Galactosidase immobilized by the carboxyl-terminal 67 amino acids of Cwp2p was most effective in the hydrolysis of the high-molecular-weight substrate guar gum from Cyamopsis tetragonoloba. This indicates that the use of a large anchoring domain does not necessarily result in a better exposure of the immobilized enzyme to the exterior of the yeast cell. PMID:9023939

  16. Synthesis of subnanometer-diameter vertically aligned single-walled carbon nanotubes with copper-anchored cobalt catalysts

    Science.gov (United States)

    Cui, Kehang; Kumamoto, Akihito; Xiang, Rong; An, Hua; Wang, Benjamin; Inoue, Taiki; Chiashi, Shohei; Ikuhara, Yuichi; Maruyama, Shigeo

    2016-01-01

    We synthesize vertically aligned single-walled carbon nanotubes (VA-SWNTs) with subnanometer diameters on quartz (and SiO2/Si) substrates by alcohol CVD using Cu-anchored Co catalysts. The uniform VA-SWNTs with a nanotube diameter of 1 nm are synthesized at a CVD temperature of 800 °C and have a thickness of several tens of μm. The diameter of SWNTs was reduced to 0.75 nm at 650 °C with the G/D ratio maintained above 24. Scanning transmission electron microscopy energy-dispersive X-ray spectroscopy (EDS-STEM) and high angle annular dark field (HAADF-STEM) imaging of the Co/Cu bimetallic catalyst system showed that Co catalysts were captured and anchored by adjacent Cu nanoparticles, and thus were prevented from coalescing into a larger size, which contributed to the small diameter of SWNTs. The correlation between the catalyst size and the SWNT diameter was experimentally clarified. The subnanometer-diameter and high-quality SWNTs are expected to pave the way to replace silicon for next-generation optoelectronic and photovoltaic devices.We synthesize vertically aligned single-walled carbon nanotubes (VA-SWNTs) with subnanometer diameters on quartz (and SiO2/Si) substrates by alcohol CVD using Cu-anchored Co catalysts. The uniform VA-SWNTs with a nanotube diameter of 1 nm are synthesized at a CVD temperature of 800 °C and have a thickness of several tens of μm. The diameter of SWNTs was reduced to 0.75 nm at 650 °C with the G/D ratio maintained above 24. Scanning transmission electron microscopy energy-dispersive X-ray spectroscopy (EDS-STEM) and high angle annular dark field (HAADF-STEM) imaging of the Co/Cu bimetallic catalyst system showed that Co catalysts were captured and anchored by adjacent Cu nanoparticles, and thus were prevented from coalescing into a larger size, which contributed to the small diameter of SWNTs. The correlation between the catalyst size and the SWNT diameter was experimentally clarified. The subnanometer-diameter and high

  17. Physical and numerical modelling of earth pressure on anchored sheet pile walls in sand

    DEFF Research Database (Denmark)

    Krogsbøll, Anette Susanne; Fuglsang, Leif D

    The influence of wall flexibility on earth pressure, bending moments and failure modes is studied. Numerical models are compared to results from model tests carried out in a geotechnical centrifuge. The back-fill is dry sand and failure is introduced by allowing the wall to rotate around the anch...

  18. Physical and numerical modelling of earth pressure on anchored sheet pile walls in sand

    DEFF Research Database (Denmark)

    Krogsbøll, Anette Susanne; Fuglsang, Leif D

    2006-01-01

    The influence of wall flexibility on earth pressure, bending moments and failure modes is studied. Numerical models are compared to results from model tests carried out in a geotechnical centrifuge. The back-fill is dry sand and failure is introduced by allowing the wall to rotate around the anch...

  19. Synthesis of subnanometer-diameter vertically aligned single-walled carbon nanotubes with copper-anchored cobalt catalysts.

    Science.gov (United States)

    Cui, Kehang; Kumamoto, Akihito; Xiang, Rong; An, Hua; Wang, Benjamin; Inoue, Taiki; Chiashi, Shohei; Ikuhara, Yuichi; Maruyama, Shigeo

    2016-01-21

    We synthesize vertically aligned single-walled carbon nanotubes (VA-SWNTs) with subnanometer diameters on quartz (and SiO2/Si) substrates by alcohol CVD using Cu-anchored Co catalysts. The uniform VA-SWNTs with a nanotube diameter of 1 nm are synthesized at a CVD temperature of 800 °C and have a thickness of several tens of μm. The diameter of SWNTs was reduced to 0.75 nm at 650 °C with the G/D ratio maintained above 24. Scanning transmission electron microscopy energy-dispersive X-ray spectroscopy (EDS-STEM) and high angle annular dark field (HAADF-STEM) imaging of the Co/Cu bimetallic catalyst system showed that Co catalysts were captured and anchored by adjacent Cu nanoparticles, and thus were prevented from coalescing into a larger size, which contributed to the small diameter of SWNTs. The correlation between the catalyst size and the SWNT diameter was experimentally clarified. The subnanometer-diameter and high-quality SWNTs are expected to pave the way to replace silicon for next-generation optoelectronic and photovoltaic devices. PMID:26690843

  20. PRACTICAL EARTH ANCHORING TECHNOLOGY FOR STRENGTHENING SLOPE WALL PROTECTION (CASE STUDY: DG. SIRUA ROAD POST CONSTRUCTION FAILURE WITH SKYHOOK ??? GRID BEAM TECHNOLOGY IN MAKASSAR CITY ??? INDONESIA)

    OpenAIRE

    Samang, Lawalenna; Hino, Takenori; Harianto, Tri; Ramli, Muhammad Isran; Walenna, Muhammad Akbar

    2013-01-01

    The application of soil anchoring system and grid beam method of strengthening protection wall post construction failure was observed in this research. The construction of the slope wall protection is situated to suit the existence of barrier made for aqueduct. Based on the numerical simulation on scenario of potential causes of slope failure, it indicates several phenomena such as the stability of barrier foundation experiences drastic drop. Scrutinizing the result of investigation and ideal...

  1. Analysis on anchoring plate retaining wall of Shanxi Science and Technology Museum%山西省科技馆锚定板挡土墙分析

    Institute of Scientific and Technical Information of China (English)

    张波

    2015-01-01

    介绍了锚定板式挡土墙的受力原理及适用条件,结合工程实例,从参数设计、土压力计算、锚定板抗拔力计算、稳定性分析等方面,阐述了锚定板挡土墙的具体设计方法,指出锚定板挡土墙具有施工速度快、造价低等优势。%This paper introduced the force principle and applicable conditions of anchoring plate retaining wall,combining with the engineering examples,from the parameter design,soil pressure calculation,anchor plate pulling force calculation,stability analysis and other aspects,elabo-rated the specific design method of anchoring plate retaining wall,pointed out that the anchoring plate retaining wall had quick construction speed,low cost and other advantages.

  2. Chemically Modified Multi-walled Carbon Nano tubes (MWCNTs) with Anchored Acidic Groups

    International Nuclear Information System (INIS)

    Surface functionalization of multi-walled carbon nano tubes (MWCNTs) was carried out using a gas phase treatment in a Universal Temperature Program (UTP) reactor by flowing SO3 gas onto the CNTs while being heated at different temperatures. The functionalized nano tubes were characterized using X-ray Fluorescence (XRF), Fourier Transform Infrared Spectroscopy (FT-IR) and Raman spectroscopy. The amount of oxygen and sulfur containing groups was determined by acid-base titration. The titration results were in good agreement with elemental analysis using x-ray fluorescence. FTIR analysis showed the presence of oxygen and sulfur containing groups, S=O, C-S, C=O and -COOH. Raman spectroscopy confirmed that oxygen and sulfur containing acidic groups covalently attached to the sidewall of the MWCNTs. (author)

  3. Role of the Group B antigen of Streptococcus agalactiae: a peptidoglycan-anchored polysaccharide involved in cell wall biogenesis.

    Directory of Open Access Journals (Sweden)

    Élise Caliot

    Full Text Available Streptococcus agalactiae (Group B streptococcus, GBS is a leading cause of infections in neonates and an emerging pathogen in adults. The Lancefield Group B carbohydrate (GBC is a peptidoglycan-anchored antigen that defines this species as a Group B Streptococcus. Despite earlier immunological and biochemical characterizations, the function of this abundant glycopolymer has never been addressed experimentally. Here, we inactivated the gene gbcO encoding a putative UDP-N-acetylglucosamine-1-phosphate:lipid phosphate transferase thought to catalyze the first step of GBC synthesis. Indeed, the gbcO mutant was unable to synthesize the GBC polymer, and displayed an important growth defect in vitro. Electron microscopy study of the GBC-depleted strain of S. agalactiae revealed a series of growth-related abnormalities: random placement of septa, defective cell division and separation processes, and aberrant cell morphology. Furthermore, vancomycin labeling and peptidoglycan structure analysis demonstrated that, in the absence of GBC, cells failed to initiate normal PG synthesis and cannot complete polymerization of the murein sacculus. Finally, the subcellular localization of the PG hydrolase PcsB, which has a critical role in cell division of streptococci, was altered in the gbcO mutant. Collectively, these findings show that GBC is an essential component of the cell wall of S. agalactiae whose function is reminiscent of that of conventional wall teichoic acids found in Staphylococcus aureus or Bacillus subtilis. Furthermore, our findings raise the possibility that GBC-like molecules play a major role in the growth of most if not all beta-hemolytic streptococci.

  4. PbsP, a cell wall-anchored protein that binds plasminogen to promote hematogenous dissemination of group B Streptococcus.

    Science.gov (United States)

    Buscetta, Marco; Firon, Arnaud; Pietrocola, Giampiero; Biondo, Carmelo; Mancuso, Giuseppe; Midiri, Angelina; Romeo, Letizia; Galbo, Roberta; Venza, Mario; Venza, Isabella; Kaminski, Pierre-Alexandre; Gominet, Myriam; Teti, Giuseppe; Speziale, Pietro; Trieu-Cuot, Patrick; Beninati, Concetta

    2016-07-01

    Streptococcus agalactiae (Group B Streptococcus or GBS) is a leading cause of invasive infections in neonates whose virulence is dependent on its ability to interact with cells and host components. We here characterized a surface protein with a critical function in GBS pathophysiology. This adhesin, designated PbsP, possesses two Streptococcal Surface Repeat domains, a methionine and lysine-rich region, and a LPXTG cell wall-anchoring motif. PbsP mediates plasminogen (Plg) binding both in vitro and in vivo and we showed that cell surface-bound Plg can be activated into plasmin by tissue plasminogen activator to increase the bacterial extracellular proteolytic activity. Absence of PbsP results in a decreased bacterial transmigration across brain endothelial cells and impaired virulence in a murine model of infection. PbsP is conserved among the main GBS lineages and is a major plasminogen adhesin in non-CC17 GBS strains. Importantly, immunization of mice with recombinant PbsP confers protective immunity. Our results indicate that GBS have evolved different strategies to recruit Plg which indicates that the ability to acquire cell surface proteolytic activity is essential for the invasiveness of this bacterium. PMID:26888569

  5. Permanent ground anchors: Nicholson design criteria

    Science.gov (United States)

    Nicholson, P. J.; Uranowski, D. D.; Wycliffe-Jones, P. T.

    1982-09-01

    The methods used by Nicholson Construction Company in the design of permanent ground anchors specifically as related to retaining walls are discussed. Basic soil parameters, design concepts, drilling and grouting methods for ground anchors are discussed. Particular emphasis is placed on anchors founded in soil rather than rock formations. Also, soil properties necessary for the proper design of anchored retaining walls are detailed. The second chapter of the report is devoted to a general discussion of retaining wall and anchor design. In addition, a design example of an anchored retaining wall is presented in a step by step manner.

  6. Bone Anchor Fixation in Abdominal Wall Reconstruction: A Useful Adjunct in Suprapubic and Para-iliac Hernia Repair.

    Science.gov (United States)

    Blair, Laurel J; Cox, Tiffany C; Huntington, Ciara R; Ross, Samuel W; Kneisl, Jeffrey S; Augenstein, Vedra A; Heniford, B Todd

    2015-07-01

    Suprapubic hernias, parailiac or flank hernias, and lumbar hernias are difficult to repair and are associated with high-recurrence rates owing to difficulty in obtaining substantive overlap and especially mesh fixation due to bone being a margin of the hernia. Orthopedic suture anchors used for ligament reconstruction have been used to attach prosthetic material to bony surfaces and can be used in the repair of these hernias where suture fixation was impossible. A prospective, single institution study of ventral hernia repairs involving bone anchor mesh fixation was performed. Demographics, operative details, and outcomes data were collected. Twenty patients were identified, with a mean age 53 (range: 35-70 years) and mean body mass index 28.4 kg/m(2) (range 21-38). Ten lumbar, seven suprapubic, and three parailiac hernias were studied. The majority were recurrent hernias (n = 13), with one to seven previously failed repairs. The mean hernia defect size was very large (270 cm(2); range: 56-832 cm(2)) with average mesh size of 1090 cm(2) (range 224-3640 cm(2)). Both Mitek GII (Depuy, Raynham, MA) and JuggerKnot 2.9-mm (Biomet, Biomedical Instruments, Warsaw, IN) anchors were used, with an average of four anchors/case (range: 1-16). Mean operative time was 218 minutes (120-495). There were three minor complications, no operative mortality, and no recurrences during an average follow-up of 24 months. Pelvic bone anchors permit mesh fixation in high-recurrence areas not amenable to traditional suture fixation. The ability to safely and effectively use bone anchor fixation is an essential tool in complex open ventral hernia repair. PMID:26140889

  7. Inactivation of the srtA Gene in Streptococcus gordonii Inhibits Cell Wall Anchoring of Surface Proteins and Decreases In Vitro and In Vivo Adhesion

    Science.gov (United States)

    Bolken, Tové C.; Franke, Christine A.; Jones, Kevin F.; Zeller, Gloria O.; Jones, C. Hal; Dutton, Emma K.; Hruby, Dennis E.

    2001-01-01

    The srtA gene product, SrtA, has been shown to be required for cell wall anchoring of protein A as well as virulence in the pathogenic bacterium Staphylococcus aureus. There are five major mechanisms for displaying proteins at the surface of gram-positive bacteria (P. Cossart and R. Jonquieres, Proc. Natl. Acad. Sci. USA 97:5013–5015, 2000). However, since many of the known surface proteins of gram-positive bacteria are believed to be exported and anchored via the sortase pathway, it was of interest to determine if srtA plays a similar role in other gram-positive bacteria. To that end, the srtA gene in the human oral commensal organism Streptococcus gordonii was insertionally inactivated. The srtA mutant S. gordonii exhibited a marked reduction in quantity of a specific anchored surface protein. Furthermore, the srtA mutant had reduced binding to immobilized human fibronectin and had a decreased ability to colonize the oral mucosa of mice. Taken together, these results suggest that the activity of SrtA plays an important role in the biology of nonpathogenic as well as pathogenic gram-positive cocci. PMID:11119491

  8. Two novel, putatively cell wall-associated and glycosylphosphatidylinositol-anchored α-glucanotransferase enzymes of Aspergillus niger

    NARCIS (Netherlands)

    Kaaij, R.M. van der; Yuan, X.L.; Franken, A.; Ram, A.F.J.; Punt, P.J.; Maarel, M.J.E.C. van der; Dijkhuizen, L.

    2007-01-01

    In the genome sequence of Aspergillus niger CBS 513.88, three genes were identified with high similarity to fungal α-amylases. The protein sequences derived from these genes were different in two ways from all described fungal α-amylases: they were predicted to be glycosylphosphatidylinositol anchor

  9. Role of the group B antigen of Streptococcus agalactiae a peptidoglycan-anchored polysaccharide involved in cell wall biogenesis : a Peptidoglycan-Anchored Polysaccharide involved in cell wall biogenesis

    OpenAIRE

    Élise Caliot; Shaynoor Dramsi; Marie-Pierre Chapot-Chartier; Pascal Courtin; Saulius Kulakauskas; Christine Péchoux; Patrick Trieu-Cuot; Michel-Yves Mistou

    2012-01-01

    Streptococcus agalactiae (Group B streptococcus, GBS) is a leading cause of infections in neonates and an emerging pathogen in adults. The Lancefield Group B carbohydrate (GBC) is a peptidoglycan-anchored antigen that defines this species as a Group B Streptococcus. Despite earlier immunological and biochemical characterizations, the function of this abundant glycopolymer has never been addressed experimentally. Here, we inactivated the gene gbcO encoding a putative UDP-N-acetylglucosamine-1-...

  10. Improved methods for binding acma-type protein anchor fusions yo cell-wall material of micro-organisms

    NARCIS (Netherlands)

    Leenhouts, Cornelis; Ramasamy, R.; Steen, Anton; Kok, Jan; Buist, Girbe; Kuipers, Oscar

    2002-01-01

    The invention provides a method for improving binding of a proteinaceous substance to cell-wall material of a Gram-positive bacterium, said substance comprising an AcmA cell wall binding domain or homolog or functional derivative thereof, said method comprising treating said cell-wall material with

  11. Role of BGT-1 and BGT-2, two predicted GPI-anchored glycoside hydrolases/glycosyltransferases, in cell wall remodeling in Neurospora crassa.

    Science.gov (United States)

    Martínez-Núñez, Leonora; Riquelme, Meritxell

    2015-12-01

    Neurospora crassa BGT-1 (NCU06381) and BGT-2 (NCU09175) are two putative glycoside hydrolases (GHs) with additional predicted glycosyltransferase activity and binding sites for a glycosyl phosphatidyl inositol (GPI) anchor that would facilitate their attachment to the plasma membrane (PM). To discern their role in key morphogenetic events during vegetative development of N. crassa, BGT-1 and BGT-2 were labeled with the green fluorescent protein (GFP). The gfp was inserted immediately after the signal peptide sequence, within the bgt-1 encoding sequence, or directly before the GPI-binding site in the case of bgt-2. Both BGT-1-GFP and BGT-2-GFP were observed at the PM of the hyphal apical dome, excluding the foremost apical region and the Spitzenkörper (Spk), where chitin and β-1,3-glucan synthases have been previously found. These and previous studies suggest a division of labor of the cell wall synthesizing machinery at the hyphal dome: at the very tip, glucans are synthesized by enzymes that accumulate at the Spk, before getting incorporated into the PM, whereas at the subtending zone below the apex, glucans are presumably hydrolyzed, producing amenable ends for further branching and crosslinking with other cell wall polymers. Additionally, BGT-1-GFP and BGT-2-GFP were observed at the leading edge of new developing septa, at unreleased interconidial junctions, at conidial poles, at germling and hyphal fusion sites, and at sites of branch emergence, all of them processes that seemingly involve cell wall remodeling. Even though single and double mutant strains for the corresponding genes did not show a drastic reduction of growth rate, bgt-2Δ and bgt-1Δ::bgt-2Δ strains exhibited an increased resistance to the cell wall stressors calcofluor white (CW) and congo red (CR) than the reference strain, which suggests they present significant architectural changes in their cell wall. Furthermore, the conidiation defects observed in the mutants indicate a significant

  12. Construction Technology of Anchor Support in Silo Wall of Large Underground Coal Storage%大型地下储煤槽仓仓壁锚杆支护施工方法

    Institute of Scientific and Technical Information of China (English)

    杨圣扩

    2012-01-01

    The silo wall in large underground coal storage is supported by anchor, which can assure stability of the anchored soil. This paper introduces in detail the characteristics of anchor support, technique principle, key operating points and quality control measures. The anchor support method is used in several projects. The application effect shows that the application of anchor in slope reinforcement can reduce soil excavation and discarding soil, decrease land use area, and so as to reduce damage to surrounding environment. The temporary anchor support surface of silo wall, also as permanent silo wall structure,can effectively shorten construction period, reduce project cost.%在大型地下储煤槽仓仓壁采用锚杆进行支护,能够保证被锚固土体的稳定.主要介绍了锚杆支护特点、工艺原理、操作要点和质量控制措施.该方法在多个项目成功应用,应用效果表明预应力锚杆在边坡加固中应用,有利于减少土方开挖和弃方量,减少用地面积,从而减少对周边环境的破坏.临时性仓壁支护锚杆面层与永久性结构仓壁合二为一,有效地缩短了施工工期,大大降低了工程投资.

  13. An asymmetric supercapacitor with ultrahigh energy density based on nickle cobalt sulfide nanocluster anchoring multi-wall carbon nanotubes hybrid

    Science.gov (United States)

    Wen, Ping; Fan, Mingjin; Yang, Desuo; Wang, Yan; Cheng, Hualei; Wang, Jinqing

    2016-07-01

    The development of novel electrode materials with high energy density and long cycling life is critical to realize electrochemical capacitive energy storage for practical applications. In this paper, the hybrids of nickle cobalt sulfide/multi-wall carbon nanotubes (NiCo2S4/MWCNTs) with different contents of MWCNTs are prepared using a facile one-pot solvothermal reaction. As novel active materials for supercapacitors, the electrochemistry tests show that the hybrid of NiCo2S4/MWCNTs-5 is able to deliver a high specific capacitance of 2080 F g-1 at the current density of 1 A g-1, even superior rate capability of 61% capacitance retention after a 20-fold increase in current densities, when the content of MWCNTs is up to 5%. More importantly, an asymmetric supercapacitor assembled by NiCo2S4/MWCNTs-5 as positive electrode and reduced graphene oxide (rGO) as negative electrode delivers a high energy density of 51.8 Wh Kg-1 at a power density of 865 W kg-1, and 85.7% of its initial capacitance is retained at the current density of 4 A g-1 after 5000 charge-discharge cycles, exhibiting potential prospect for practical applications.

  14. Stress Analysis of Building Curtain Wall Post Embedment Anchor Bolt%建筑幕墙后置埋件锚栓受力分析

    Institute of Scientific and Technical Information of China (English)

    陆新鑫; 吴强

    2014-01-01

    本文根据JGJ 145—2013《混凝土结构后锚固技术规程》第5.2.2条,对后置埋件在双向受弯矩、双向受剪力、以及扭矩、拉力的共同作用下进行的锚栓受力做了分析,提出了复合力作用下后置埋件锚栓的计算公式。%This paper, according to article 5.2.2 of JGJ 145 -2013 “technical specification for concrete structure of anch-oring force”, made an analysis of the force analysis of post anchor bolt under the interaction of bi-directional torque, shear force, bending, put ing forward the calculation formula of posts anchor bolt under composite force.

  15. Anchored nanostructure materials and method of fabrication

    Science.gov (United States)

    Seals, Roland D; Menchhofer, Paul A; Howe, Jane Y; Wang, Wei

    2012-11-27

    Anchored nanostructure materials and methods for their fabrication are described. The anchored nanostructure materials may utilize nano-catalysts that include powder-based or solid-based support materials. The support material may comprise metal, such as NiAl, ceramic, a cermet, or silicon or other metalloid. Typically, nanoparticles are disposed adjacent a surface of the support material. Nanostructures may be formed as anchored to nanoparticles that are adjacent the surface of the support material by heating the nano-catalysts and then exposing the nano-catalysts to an organic vapor. The nanostructures are typically single wall or multi-wall carbon nanotubes.

  16. 基于框架预应力锚杆加固技术的重力式挡土墙的稳定性分析%Stability analysis of gravity retaining wall reinforced with framed prestressed anchors

    Institute of Scientific and Technical Information of China (English)

    朱彦鹏; 王勇; 周勇

    2012-01-01

    Based on the instability phenomenon of gravity retaining wall, the framed anchor with prestress was used to reinforce the retaining wall. On the basis of limit equilibrium theory and Coulomb earth pressure theory, the stability of retaining walls was analyzed and the solution formula of safety coefficient of stability of anti-slip and anti-overturning was derived. It was shown by illustrative computation and cont-rastive analysis, the result showed that the safety coefficient of stability of the gravity retaining wall with this kind of reinforcement techniques was significantly improved. The safety coefficient of stability would be increased by about 50% when the prestress was increased by 50 kN. However, taking the economic and security aspects into account, 100 kN prestress applied to the anchors would be the most optimaL%基于重力式挡土墙不稳定的现象,运用框架预应力锚杆加固技术对重力式挡土墙进行加固.以极限平衡理论及库仑土压力理论为基础,对挡土墙进行稳定性分析,推导出挡土墙的抗滑移稳定性和抗倾覆稳定性安全系数的求解计算公式.通过算例计算及对比分析,结果显示引入此加固技术的重力式挡墙的稳定性安全系数明显提高,在锚杆预应力每增加50 kN时,稳定性安全系数提高的幅度达到50%左右;从经济性和安全性两方面综合考虑,对锚杆施加100kN的预应力是最佳的.

  17. wall

    Directory of Open Access Journals (Sweden)

    Irshad Kashif

    2016-01-01

    Full Text Available Maintaining indoor climatic conditions of buildings compatible with the occupant comfort by consuming minimum energy, especially in a tropical climate becomes a challenging problem for researchers. This paper aims to investigate this problem by evaluating the effect of different kind of Photovoltaic Trombe wall system (PV-TW on thermal comfort, energy consumption and CO2 emission. A detailed simulation model of a single room building integrated with PV-TW was modelled using TRNSYS software. Results show that 14-35% PMV index and 26-38% PPD index reduces as system shifted from SPV-TW to DGPV-TW as compared to normal buildings. Thermal comfort indexes (PMV and PPD lie in the recommended range of ASHARE for both DPV-TW and DGPV-TW except for the few months when RH%, solar radiation intensity and ambient temperature were high. Moreover PVTW system significantly reduces energy consumption and CO2 emission of the building and also 2-4.8 °C of temperature differences between indoor and outdoor climate of building was examined.

  18. Hypersensitivity to Suture Anchors

    Directory of Open Access Journals (Sweden)

    Masafumi Goto

    2013-01-01

    Full Text Available Hypersensitivity to suture anchor is extremely rare. Herein, we present a case in which hypersensitivity to suture anchor was strongly suspected. The right rotator cuff of a 50-year-old woman was repaired with a metal suture anchor. Three weeks after the surgery, she developed erythema around her face, trunk, and hands, accompanied by itching. Infection was unlikely because no abnormalities were detected by blood testing or by medical examination. Suspicious of a metallic allergy, a dermatologist performed a patch testing 6 months after the first surgery. The patient had negative reactions to tests for titanium, aluminum, and vanadium, which were the principal components of the suture anchor. The anchor was removed 7 months after the first surgery, and the erythema disappeared immediately. When allergic symptoms occur and persist after the use of a metal anchor, removal should be considered as a treatment option even if the patch test result is negative.

  19. Susceptibility to anchoring effects

    Directory of Open Access Journals (Sweden)

    Todd McElroy

    2007-02-01

    Full Text Available Previous research on anchoring has shown this heuristic to be a very robust psychological phenomenon ubiquitous across many domains of human judgment and decision-making. Despite the prevalence of anchoring effects, researchers have only recently begun to investigate the underlying factors responsible for how and in what ways a person is susceptible to them. This paper examines how one such factor, the Big-Five personality trait of openness-to-experience, influences the effect of previously presented anchors on participants' judgments. Our findings indicate that participants high in openness-to-experience were significantly more influenced by anchoring cues relative to participants low in this trait. These findings were consistent across two different types of anchoring tasks providing convergent evidence for our hypothesis.

  20. Anchoring visions in organizations

    DEFF Research Database (Denmark)

    Simonsen, Jesper

    1999-01-01

    This paper introduces the term 'anchoring' within systems development: Visions, developed through early systems design within an organization, need to be deeply rooted in the organization. A vision's rationale needs to be understood by those who decide if the vision should be implemented as well as...... anchoring is considered to be a main activity, is outlined. The task of anchoring visions is described, and techniques and activities are suggested with respect to those actors that have to act on the visions and the recommendations from a design proposal. The paper concludes that obtaining appropriate...

  1. Susceptibility to anchoring effects

    OpenAIRE

    Todd McElroy; Keith Dowd

    2007-01-01

    Previous research on anchoring has shown this heuristic to be a very robust psychological phenomenon ubiquitous across many domains of human judgment and decision-making. Despite the prevalence of anchoring effects, researchers have only recently begun to investigate the underlying factors responsible for how and in what ways a person is susceptible to them. This paper examines how one such factor, the Big-Five personality trait of openness-to-experience, influences the effect of previously p...

  2. Liquid crystal director fluctuations and surface anchoring by molecular simulation

    OpenAIRE

    Andrienko, D.; Germano, G; Allen, M. P.

    2002-01-01

    We propose a simple and reliable method to measure the liquid crystal surface anchoring strength by molecular simulation. The method is based on the measurement of the long-range fluctuation modes of the director in confined geometry. As an example, molecular simulations of a liquid crystal in slab geometry between parallel walls with homeotropic anchoring have been carried out using the Monte Carlo technique. By studying different slab thicknesses, we are able to calculate separately the pos...

  3. Anchoring the Deficit of the Anchor Deficit: Dyslexia or Attention?

    Science.gov (United States)

    Willburger, Edith; Landerl, Karin

    2010-01-01

    In the anchoring deficit hypothesis of dyslexia ("Trends Cogn. Sci.", 2007; 11: 458-465), it is proposed that perceptual problems arise from the lack of forming a perceptual anchor for repeatedly presented stimuli. A study designed to explicitly test the specificity of the anchoring deficit for dyslexia is presented. Four groups, representing all…

  4. Robotic Ankle for Omnidirectional Rock Anchors

    Science.gov (United States)

    Parness, Aaron; Frost, Matthew; Thatte, Nitish

    2013-01-01

    Future robotic exploration of near-Earth asteroids and the vertical and inverted rock walls of lava caves and cliff faces on Mars and other planetary bodies would require a method of gripping their rocky surfaces to allow mobility without gravitational assistance. In order to successfully navigate this terrain and drill for samples, the grippers must be able to produce anchoring forces in excess of 100 N. Additionally, the grippers must be able to support the inertial forces of a moving robot, as well gravitational forces for demonstrations on Earth. One possible solution would be to use microspine arrays to anchor to rock surfaces and provide the necessary load-bearing abilities for robotic exploration of asteroids. Microspine arrays comprise dozens of small steel hooks supported on individual suspensions. When these arrays are dragged along a rock surface, the steel hooks engage with asperities and holes on the surface. The suspensions allow for individual hooks to engage with asperities while the remaining hooks continue to drag along the surface. This ensures that the maximum possible number of hooks engage with the surface, thereby increasing the load-bearing abilities of the gripper. Using the microspine array grippers described above as the end-effectors of a robot would allow it to traverse terrain previously unreachable by traditional wheeled robots. Furthermore, microspine-gripping robots that can perch on cliffs or rocky walls could enable a new class of persistent surveillance devices for military applications. In order to interface these microspine grippers with a legged robot, an ankle is needed that can robotically actuate the gripper, as well as allow it to conform to the large-scale irregularities in the rock. The anchor serves three main purposes: deploy and release the anchor, conform to roughness or misalignment with the surface, and cancel out any moments about the anchor that could cause unintentional detachment. The ankle design contains a

  5. Study of two dimensional nematic liquid crystal reorientations and anchoring effects

    OpenAIRE

    S Shoarinejad; MA Shahzamanian

    2010-01-01

    In this paper, the director distribution is calculated for a nematic liquid crystal, in the cell with different surface anchoring conditions and external fields. The effects of finite and infinite surface anchoring on molecular orientations for one dimensional geometry are discussed. In these situations, the planar alignment is considered. Then, in a two dimensional geometry the planar and homotropic anchoring conditions are assumed for wall- interfaces of confined nematic, and the reorientat...

  6. The Anchoring Concept

    DEFF Research Database (Denmark)

    Simonsen, Jesper

    1998-01-01

    This paper introduces the term 'anchoring' within systems development: Visions, developed through early systems design within an organization, need to be deeply rooted in the organization. A vision's rationale needs to be understood by those who decide if the vision should be implemented as well as...... by those involved in the actual implementation. A model depicting a recent trend within systems development is presented: Organizations rely on purchasing generic software products and/or software development outsourced to external contractors. A contemporary method for participatory design, where...

  7. Bone Anchored Hearing Treatment Procedure

    Medline Plus

    Full Text Available ... skin to allow removal of some of the soft tissue where the screwlike fixture will be anchored. The ... screen, acting as a hinge. Beneath that the soft tissue consisting of fat and some muscle is removed. ...

  8. Bone Anchored Hearing Treatment Procedure

    Medline Plus

    Full Text Available ... to allow removal of some of the soft tissue where the screwlike fixture will be anchored. The ... series of slides demonstrates the removal of the tissue beneath the skin flap. You can see in ...

  9. Bone Anchored Hearing Treatment Procedure

    Medline Plus

    Full Text Available ... The Baha system consists of a bone-anchored titanium fixture that is implanted in the mastoid bone, ... the -- great. I'm going to grab the titanium implant. And what I want you to notice ...

  10. Bone Anchored Hearing Treatment Procedure

    Medline Plus

    Full Text Available ... of the bone oscillator is superficial on the skin, the transference of that energy is less efficient, ... slides, is to mark the location in the skin where the screwlike fixture will be anchored. Subsequent ...

  11. Effects of Anchor Bolts Failures in Steam Explosion Analyses

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Seung Hyun; Chang, Yoon-Suk [Kyung Hee University, Yongin (Korea, Republic of); Song, Sungchu; Cho, Yong-Jin [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

    2015-05-15

    Steam explosion may occur in a nuclear power plant by molten core-coolant interactions when the external reactor vessel cooling strategy is failed. This phenomenon can threat the integrity of reactor cavity, penetration piping and support structures. Even though extensive researches have been performed to predict influences of the steam explosion, due to complexity of physical phenomena and environmental thermal hydraulic conditions, it is remained as one of possible hazards. A steam explosion can cause intensive and rapid heat transfer, and lead to the formation of pressure waves and production of missiles that may endanger surrounding reactor cavity wall and associate components due to resulting dynamic effects. The goal of this research is to examine structural integrity of RPV (Reactor Pressure Vessel) support structures and anchor bolts under typical ex-vessel steam explosion conditions through FE analyses. Particularly, influence due to the failure of anchor bolts connecting RPV and support structures was evaluated. In this paper, influence of RPV and support structure due to the anchor bolt failure were evaluated under typical steam explosion conditions and the following conclusions were derived. The highest maximum stresses were calculated at the support structures under the steam explosion condition with the SVF and anchor bolts non-failure. The all stress values did not exceed their yield strengths. The displacements were high under anchor bolt failure conditions. However, the vertical movements of major components were small comparing to the overall dimensions of them.

  12. Cell wall sorting signals in surface proteins of gram-positive bacteria.

    OpenAIRE

    Schneewind, O; Mihaylova-Petkov, D; Model, P

    1993-01-01

    Staphylococcal protein A is anchored to the cell wall, a unique cellular compartment of Gram-positive bacteria. The sorting signal sufficient for cell wall anchoring consists of an LPXTG motif, a C-terminal hydrophobic domain and a charged tail. Homologous sequences are found in many surface proteins of Gram-positive bacteria and we explored the universality of these sequences to serve as cell wall sorting signals. We show that several signals are able to anchor fusion proteins to the staphyl...

  13. An accessory protein required for anchoring and assembly of amyloid fibres in B. subtilis biofilms.

    Science.gov (United States)

    Romero, Diego; Vlamakis, Hera; Losick, Richard; Kolter, Roberto

    2011-06-01

    Cells within Bacillus subtilis biofilms are held in place by an extracellular matrix that contains cell-anchored amyloid fibres, composed of the amyloidogenic protein TasA. As biofilms age they disassemble because the cells release the amyloid fibres. This release appears to be the consequence of incorporation of D-tyrosine, D-leucine, D-tryptophan and D-methionine into the cell wall. Here, we characterize the in vivo roles of an accessory protein TapA (TasA anchoring/assembly protein; previously YqxM) that serves both to anchor the fibres to the cell wall and to assemble TasA into fibres. TapA is found in discrete foci in the cell envelope and these foci disappear when cells are treated with a mixture of D-amino acids. Purified cell wall sacculi retain a functional form of this anchoring protein such that purified fibres can be anchored to the sacculi in vitro. In addition, we show that TapA is essential for the proper assembly of the fibres. Its absence results in a dramatic reduction in TasA levels and what little TasA is left produces only thin fibres that are not anchored to the cell. PMID:21477127

  14. Vertical Equilibrium of Sheet Pile Walls with Emphasis on Toe Capacity and Plugging

    DEFF Research Database (Denmark)

    Iversen, Kirsten Malte; Augustesen, Anders Hust; Nielsen, Benjaminn Nordahl

    Constructions including retaining walls are normally established in areas where it is impossible to conduct an excavation with inclined sides. Due to large excavation depths and due to restrictions on the deformations of the wall, it is often necessary to anchor the wall. The limited space makes it...... at the pile toe to fulfil vertical equilibrium. The paper describes a case study of sheet pile walls in Aalborg Clay, and the amount of loads transferred as point loads at the pile toe for free and anchored walls is estimated. A parametric study is made for the free wall with regards to the height...... and the roughness of the wall. Due to limitations of the calculation method, the study of the anchored wall only includes variation of the roughness. For the case study, it is found that the vertical equilibrium is fulfilled for the considered free wall. An anchored wall needs a plug forming at the...

  15. Anchoring in numeric judgments of visual stimuli

    Directory of Open Access Journals (Sweden)

    Linda eLangeborg

    2016-02-01

    Full Text Available This article investigates effects of anchoring in age estimation and estimation of quantities, two tasks which to different extents are based on visual stimuli. The results are compared to anchoring in answers to classic general knowledge questions that rely on semantic knowledge. Cognitive load was manipulated to explore possible differences between domains. Effects of source credibility, manipulated by differing instructions regarding the selection of anchor values (no information regarding anchor selection, information that the anchors are randomly generated or information that the anchors are answers from an expert on anchoring were also investigated. Effects of anchoring were large for all types of judgments but were not affected by cognitive load or by source credibility in either one of the researched domains. A main effect of cognitive load on quantity estimations and main effects of source credibility in the two visually based domains indicate that the manipulations were efficient. Implications for theoretical explanations of anchoring are discussed. In particular, because anchoring did not interact with source credibility or cognitive load, the results imply that the process behind anchoring in visual tasks is predominantly automatic and unconscious.

  16. Inconspicuous anchoring effects generated by false information

    Institute of Scientific and Technical Information of China (English)

    Chen Qu; Jun Wang; Yuejia Luo

    2008-01-01

    The impact of false information on numerical judgments was examined on young normal subjects by an event-related potential (ERP) experiment. To imitate the judgments in real world, we ensured the subjects acknowledged of the target task. The behavioral results found that both uncertain information and false information assimilated the final estimates: higher after higher anchors and lower after lower anchors; and false information caused a weaker anchoring bias than uncertain information. ERP results provided further electrophysiological evidence for the mechanism of anchoring. In the early phrase, it was an accessibility-dominated process in which two kinds of anchors elicited an N300 component related to the accessibility of anchors propositions. The knowledge relevant to targets joined the process in the late phrase, which caused a larger amplitude of late positive component (LPC) for implausible lower anchors than that for plausible higher anchors. Source analysis showed that medial frontal gyrus, whose activity was suggested to signal the need of adjustment, was more reliable to explain the LPC elicited by implausible lower anchors. Therefore, we suggest that accessibility is facilitated when the external anchor is consistent with the world knowledge, and adjustment is initiated when the external anchor is inconsistent.

  17. Anchoring in Numeric Judgments of Visual Stimuli.

    Science.gov (United States)

    Langeborg, Linda; Eriksson, Mårten

    2016-01-01

    This article investigates effects of anchoring in age estimation and estimation of quantities, two tasks which to different extents are based on visual stimuli. The results are compared to anchoring in answers to classic general knowledge questions that rely on semantic knowledge. Cognitive load was manipulated to explore possible differences between domains. Effects of source credibility, manipulated by differing instructions regarding the selection of anchor values (no information regarding anchor selection, information that the anchors are randomly generated or information that the anchors are answers from an expert) on anchoring were also investigated. Effects of anchoring were large for all types of judgments but were not affected by cognitive load or by source credibility in either one of the researched domains. A main effect of cognitive load on quantity estimations and main effects of source credibility in the two visually based domains indicate that the manipulations were efficient. Implications for theoretical explanations of anchoring are discussed. In particular, because anchoring did not interact with cognitive load, the results imply that the process behind anchoring in visual tasks is predominantly automatic and unconscious. PMID:26941684

  18. Simulation study of liquid crystal anchoring at a polymer surface

    Science.gov (United States)

    Hamaneh, Mehdi

    2005-03-01

    The process of rubbing a polymer substrate to induce planar anchoring has two effects. It aligns the polymer chains and also creates grooves in the surface. We have investigated which one of these effects is more important by conducting a series of simulations of molecules of 5CB in contact with a poly(vinyl alcohol) surface. The polymer surface was constructed from a set of parallel straight chains. It was then distorted to mimic the effect of grooves in a direction perpendicular to the chain direction, thus causing two opposing anchoring effects. It was found that the 5CB molecules ordered preferentially along the chain direction when the depth of the grooves was less than 20 percent of the distance between grooves. For grooves whose walls were more steeply pitched, the nematic ordering aligned with the grooves.

  19. Anchors and their use in offshore petroleum operations

    Energy Technology Data Exchange (ETDEWEB)

    1984-01-01

    Holding a ship or vessel in a fixed position over specific spots is essential in drilling subsea wells. Conventional anchors and holding systems have thus been transformed into permanent mooring points capable of withstanding enormous stresses. This book specifies the parameters directly governing behavior of these new anchors, studies the mechanisms involved in anchor/seabed interaction and interprets these in the context of soil mechanics, and draws practical conclusions in the form of methods for predicting holding capacity in different types of subsea soils. Contents are: history of anchors; high-capacity anchoring systems; kinetics of anchors; holding power of anchors; anchoring site survey; choice of an anchor; and anchoring tests.

  20. Cell Wall Anchoring of the Campylobacter Antigens to Lactococcus lactis.

    Science.gov (United States)

    Kobierecka, Patrycja A; Olech, Barbara; Książek, Monika; Derlatka, Katarzyna; Adamska, Iwona; Majewski, Paweł M; Jagusztyn-Krynicka, Elżbieta K; Wyszyńska, Agnieszka K

    2016-01-01

    Campylobacter jejuni is the most frequent cause of human food-borne gastroenteritis and chicken meat is the main source of infection. Recent studies showed that broiler chicken immunization against Campylobacter should be the most efficient way to lower the number of human infections by this pathogen. Induction of the mucosal immune system after oral antigen administration should provide protective immunity to chickens. In this work we tested the usefulness of Lactococcus lactis, the most extensively studied lactic acid bacterium, as a delivery vector for Campylobacter antigens. First we constructed hybrid protein - CjaA antigen presenting CjaD peptide epitopes on its surface. We showed that specific rabbit anti-rCjaAD serum reacted strongly with both CjaA and CjaD produced by a wild type C. jejuni strain. Next, rCjaAD and CjaA were fused to the C-terminus of the L. lactis YndF containing the LPTXG motif. The genes expressing these proteins were transcribed under control of the L. lactis Usp45 promoter and their products contain the Usp45 signal sequences. This strategy ensures a cell surface location of both analyzed proteins, which was confirmed by immunofluorescence assay. In order to evaluate the impact of antigen location on vaccine prototype efficacy, a L. lactis strain producing cytoplasm-located rCjaAD was also generated. Animal experiments showed a decrease of Campylobacter cecal load in vaccinated birds as compared with the control group and showed that the L. lactis harboring the surface-exposed rCjaAD antigen afforded greater protection than the L. lactis producing cytoplasm-located rCjaAD. To the best of our knowledge, this is the first attempt to employ Lactic Acid Bacteria (LAB) strains as a mucosal delivery vehicle for chicken immunization. Although the observed reduction of chicken colonization by Campylobacter resulting from vaccination was rather moderate, the experiments showed that LAB strains can be considered as an alternative vector to deliver heterologous antigens to the bird immune system. Additionally, the analysis of the structure and immunogenicity of the generated rCjaAD hybrid protein showed that the CjaA antigen can be considered as a starting point to construct multiepitope anti-Campylobacter vaccines. PMID:26925040

  1. Protein transport across the cell wall of monoderm Gram-positive bacteria

    OpenAIRE

    Forster, Brian M.; Marquis, Hélène

    2012-01-01

    In monoderm (single membrane) Gram-positive bacteria, the majority of secreted proteins are first translocated across the cytoplasmic membrane into the inner wall zone. For a subset of these proteins, final destination is within the cell envelope either as membrane-anchored or cell wall-anchored proteins, whereas another subset of proteins is destined to be transported across the cell wall into the extracellular milieu. Although the cell wall is a porous structure, there is evidence that, for...

  2. Shifting Nominal Anchors: The Experience of Mexico

    OpenAIRE

    Leonardo Leiderman; Nissan Liviatan; Alfredo Thorne

    1995-01-01

    In the mid-1980’s Mexico successfully brought down its high rate of inflation by using the exchange rate as nominal anchor in combination with strict fiscal discipline, tight monetary policy, and incomes policy. This paper discusses the role of exchange rate policy as nominal anchor in Mexico and develops the inflation target as the monetary framework for anchoring prices. It also describes how Mexico is applying this frame work while shifting to a more flexible exchange regime and discusses ...

  3. Capital Asset Pricing Model Adjusted for Anchoring

    OpenAIRE

    Hammad, Siddiqi

    2015-01-01

    I show that adjusting CAPM for anchoring provides a unified explanation for the size, value, and momentum effects. Anchoring adjusted CAPM (ACAPM) predicts that stock splits are associated with positive abnormal returns and an increase in return volatility, whereas the reverse stock-splits are associated with negative abnormal returns and a fall in return volatility. Existing empirical evidence strongly supports these predictions. Anchoring has the effect of pushing up the equity premium, a ...

  4. Method of fabrication of anchored nanostructure materials

    Science.gov (United States)

    Seals, Roland D; Menchhofer, Paul A; Howe, Jane Y; Wang, Wei

    2013-11-26

    Methods for fabricating anchored nanostructure materials are described. The methods include heating a nano-catalyst under a protective atmosphere to a temperature ranging from about 450.degree. C. to about 1500.degree. C. and contacting the heated nano-catalysts with an organic vapor to affix carbon nanostructures to the nano-catalysts and form the anchored nanostructure material.

  5. Suction anchors for floating production systems

    Energy Technology Data Exchange (ETDEWEB)

    Tjelta, T.I.; Rusas, P. [Statoil a.s. (Norway); Edvardsen, G. [HEX a.s. (Norway)

    1996-12-31

    Since the suction anchor is a recent development in its current use, this work provides a brief historical background. It is shown that the suction anchor throughout evolution today is a competitive foundation solution for many applications. Examples from these categories are included in this paper. Also several installation methods are discussed. 3 refs., 7 figs., 2 tabs.

  6. Cell wall sorting of lipoproteins in Staphylococcus aureus.

    OpenAIRE

    Navarre, W W; Daefler, S; Schneewind, O

    1996-01-01

    Many surface proteins are thought to be anchored to the cell wall of gram-positive organisms via their C termini, while the N-terminal domains of these molecules are displayed on the bacterial surface. Cell wall anchoring of surface proteins in Staphylococcus aureus requires both an N-terminal leader peptide and a C-terminal cell wall sorting signal. By fusing the cell wall sorting of protein A to the C terminus of staphylococcal beta-lactamase, we demonstrate here that lipoproteins can also ...

  7. An Accessory Protein Required for Anchoring and Assembly of Amyloid Fibers in B. subtilis Biofilms

    OpenAIRE

    Romero, Diego; Vlamakis, Hera; Losick, Richard; Kolter, Roberto

    2011-01-01

    Cells within Bacillus subtilis biofilms are held in place by an extracellular matrix that contains cell-anchored amyloid fibers, composed of the amyloidogenic protein TasA. As biofilms age they disassemble because the cells release the amyloid fibers. This release appears to be the consequence of incorporation of D-tyrosine, D-leucine, D-tryptophan and D-methionine into the cell wall. Here, we characterize the in vivo roles of an accessory protein TapA (TasA anchoring/assembly protein; previo...

  8. Construction of a highly active xylanase displaying oleaginous yeast: comparison of anchoring systems.

    Directory of Open Access Journals (Sweden)

    Sophie Duquesne

    Full Text Available Three Yarrowia lipolytica cell wall proteins (YlPir, YlCWP1 and YlCBM were evaluated for their ability to display the xylanase TxXYN from Thermobacillus xylanilyticus on the cell surface of Y. lipolytica. The fusion proteins were produced in Y. lipolytica JMY1212, a strain engineered for mono-copy chromosomal insertion, and enabling accurate comparison of anchoring systems. The construction using YlPir enabled cell bound xylanase activity to be maximised (71.6 U/g. Although 48% of the activity was released in the supernatant, probably due to proteolysis at the fusion zone, this system is three times more efficient for the anchoring of TxXYN than the YlCWP1 system formerly developed for Y. lipolytica. As far as we know it represents the best displayed xylanase activity ever published. It could be an attractive alternative anchoring system to display enzymes in Y. lipolytica.

  9. Mooring Anchors for Marine Renewable Energy Foundations

    OpenAIRE

    Stevens, Robert F.; Rahim, Amir

    2014-01-01

    With the increasing use of offshore wind turbines, it has become necessary to explore deep-water sites for locating wind farms. Floating turbines are an ideal choice for these locations. Such turbines are anchored with mooring chains to the sea floor using suction anchors, driven piles or gravity foundations. This paper presents design methods for these types of foundations. Moored gravity foundations have been used for the much larger floating oil and gas installations. These concrete founda...

  10. Anchoring Adjusted Capital Asset Pricing Model

    OpenAIRE

    Hammad, Siddiqi

    2015-01-01

    An anchoring adjusted Capital Asset Pricing Model (ACAPM) is developed in which the payoff volatilities of well-established stocks are used as starting points that are adjusted to form volatility judgments about other stocks. Anchoring heuristic implies that such adjustments are typically insufficient. ACAPM converges to CAPM with correct adjustment, so CAPM is a special case of ACAPM. The model provides a unified explanation for the size, value, and momentum effects in the stock market. A ke...

  11. FRP-to-concrete joint assemblies anchored with multiple FRP anchors: experimental investigation

    OpenAIRE

    Zhang, H.; Smith, ST

    2010-01-01

    Higher strains can be developed in fibre-reinforced polymer (FRP) composites which are bonded to the surfaces of concrete members if the FRP is anchored. Anchors made from FRP (also known as FRP spike anchors but herein referred to as FRP anchors) are a promising type of anchorage as they can be applied to a variety of different shaped structural elements and they have been shown to be effective in en-hancing the strain capacity of externally bonded FRP. Limited research, however, has been co...

  12. Bacterial glycobiology: rhamnose-containing cell wall polysaccharides in Gram-positive bacteria.

    OpenAIRE

    Mistou, Michel-Yves; Sutcliffe, Iain; van Sorge, Nina

    2016-01-01

    The composition of the Gram-positive cell wall is typically described as containing peptidoglycan, proteins and essential secondary cell wall structures called teichoic acids, which comprise approximately half of the cell wall mass. The cell walls of many species within the genera Streptococcus, Enterococcus and Lactococcus contain large amounts of the sugar rhamnose, which is incorporated in cell wall-anchored polysaccharides (CWP) that possibly function as homologues of well-studied wall te...

  13. Anchors as Semantic Primes in Value Construction: An EEG Study of the Anchoring Effect.

    Directory of Open Access Journals (Sweden)

    Qingguo Ma

    Full Text Available Previous research regarding anchoring effects has demonstrated that human judgments are often assimilated to irrelevant information. Studies have demonstrated that anchors influence the economic valuation of various products and experiences; however, the cognitive explanations of this effect remain controversial, and its neural mechanisms have rarely been explored. In the current study, we conducted an electroencephalography (EEG experiment to investigate the anchoring effect on willingness to accept (WTA for an aversive hedonic experience and the role of anchors in this judgment heuristic. The behavioral results demonstrated that random numbers affect participants' WTA for listening to pieces of noise. The participants asked for higher pay after comparing their WTA with higher numbers. The EEG results indicated that anchors also influenced the neural underpinnings of the valuation process. Specifically, when a higher anchor number was drawn, larger P2 and late positive potential amplitudes were elicited, reflecting the anticipation of more intensive pain from the subsequent noise. Moreover, higher anchors induced a stronger theta band power increase compared with lower anchors when subjects listened to the noises, indicating that the participants felt more unpleasant during the actual experience of the noise. The levels of unpleasantness during both anticipation and experience were consistent with the semantic information implied by the anchors. Therefore, these data suggest that a semantic priming process underlies the anchoring effect in WTA. This study provides proof for the robustness of the anchoring effect and neural evidence of the semantic priming model. Our findings indicate that activated contextual information, even seemingly irrelevant, can be embedded in the construction of economic value in the brain.

  14. Effects of wetting and anchoring on capillary phenomena in a confined liquid crystal.

    Science.gov (United States)

    De Las Heras, D; Velasco, E; Mederos, L

    2004-03-01

    A fluid of hard spherocylinders of length-to-breadth ratio L/D=5 confined between two identical planar, parallel walls--forming a pore of slit geometry--has been studied using a version of the Onsager density-functional theory. The walls impose an exclusion boundary condition over the particle's centers of mass, while at the same time favoring a particular anchoring at the walls, either parallel or perpendicular to the substrate. We observe the occurrence of a capillary transition, i.e., a phase transition associated with the formation of a nematic film inside the pore at a chemical potential different from micro(b)-the chemical potential at the bulk isotropic-nematic transition. This transition terminates at an Ising-type surface critical point. In line with previous studies based on the macroscopic Kelvin equation and the mesoscopic Landau-de Gennes approach, our microscopic model indicates that the capillary transition is greatly affected by the wetting and anchoring properties of the semi-infinite system, i.e., when the fluid is in contact with a single wall or, equivalently, the walls are at a very large distance. Specifically, in a situation where the walls are preferentially wetted by the nematic phase in the semi-infinite system, one has the standard scenario with the capillary transition taking place at chemical potentials less than micro(b) (capillary nematization transition or capillary ordering transition). By contrast, if the walls tend to orientationally disorder the fluid, the capillary transition may occur at chemical potentials larger than micro(b), in what may be called a capillary isotropization transition or capillary disordering transition. Moreover, the anchoring transition that occurs in the semi-infinite system may affect very decisively the confinement properties of the liquid crystal and the capillary transitions may become considerably more complicated. PMID:15267357

  15. Monitoring ground anchor using non-destructive ground anchor integrity test (NDT-GRANIT)

    International Nuclear Information System (INIS)

    Monitoring at ground anchor commonly uses a pull out test method, therefor we developing a non-destructive ground anchor integrity testing (NDT-GRANIT). NDT-GRANIT using the principle of seismic waves that have been modified into form of sweep signal, the signal will be demodulated, filtered, and Fourier transformation (inverse discrete Fourier transform) so the data can be interpreted reflected wave from the ground anchor. The method was applied to determine whether the ground anchor still gripped in the subsurface by looking the attenuation of the wave generated sources. From the result we can see that ground anchor does not grip. To validate the results of the comparison method of measurement used pile integrity test

  16. Percutaneous Transcholecystic Biliary Interventions Using Gallbladder Anchors: Feasibility Study in the Swine

    International Nuclear Information System (INIS)

    The purpose of this study was to report our initial experience with a swine model for biliary interventions by using a percutaneous transcholecystic access after suture anchor of the gallbladder. Telepaque tablets were given to five pigs to opacify the gallbladder. Under fluoroscopy, the opacified gallbladder was punctured percutaneously and three suture anchors were used to fix the anterior wall of the gallbladder to the abdominal wall. Two weeks later, the gallbladder was punctured and access into the distal common bile was obtained through the cystic duct. Balloon expandable stents were deployed into the distal common bile duct. Follow-up cholangiograms were obtained at 1 and 2 weeks. Necropsy was performed after 2 weeks to evaluate the relationship between the gallbladder and abdominal wall. Suture anchor placement was successful in all five pigs. One pig with a deep and highly positioned gallbladder developed fever, anorexia, and vomiting secondary to excessive stretch of the gallbladder. Placement of the guidewire through the extremely tortuous and small cystic ducts proved to be the most challenging step of the procedure. Metallic stents were successfully deployed in all four pigs in which it was attempted. Four animals tolerated the procedures without changes in their clinical conditions and no symptoms. Successful follow-up cholangiograms were performed at 1 and 2 weeks post-stent deployment without complications. All stents remained patent during the follow-up period. Necropsy demonstrated close attachment and adherence of the gallbladders to the antero-lateral abdominal wall in all four animals. Suture anchoring of the gallbladder is feasible in most pigs with superficially located gallbladders. This technique allows a safe and repeat access into the biliary system using a transcholecystic approach

  17. Energy dissipation and high-strain rate dynamic response of E-glass fiber composites with anchored carbon nanotubes

    Science.gov (United States)

    This study explores the mechanical properties of an E-glass fabric composite reinforced with anchored multi-walled carbon nanotubes (CNTs). The CNTs were grown on the E-glass fabric using a floating catalyst chemical vapor deposition procedure. The E-glass fabric with attached CNTs was then incorpor...

  18. ANCHORING EFFECT ANALYSIS OF TENSIONED BOLTS

    Institute of Scientific and Technical Information of China (English)

    夏建中

    1997-01-01

    The paper analyses quantitatively the anchoring effect of tensioned bolts on surrounding rock strength, and defines two concepts: one is the surrounding rock strength increased amount △τ13 and the other is the strength influence factor k. The anchoring effect of tensioned bolts is considered to increase a strength increased amount △τ13 where △τ13 is the product k and tensioned load p, i. e. △τ13= kp, where k is a function of two variables x and y. The distributive properties both △τ13 and k are also discussed in the paper, obtaining some useful results for designing bolting support parameters.

  19. Cell Wall

    OpenAIRE

    Jamet, Elisabeth; Canut, Hervé; Boudart, Georges; Albenne, Cécile; Pont-Lezica, Rafael F

    2008-01-01

    This chapter covers our present knowledge of cell wall proteomics highlighting the distinctive features of cell walls and cell wall proteins in relation to problems encountered for protein extraction, separation and identification. It provides clues to design strategies for efficient cell wall proteomic studies. It gives an overview of the kinds of proteins that have yet been identified: the expected proteins vs the identified proteins. Finally, the new vision of the cell wall proteome, and t...

  20. Monogenean anchor morphometry: systematic value, phylogenetic signal, and evolution.

    Science.gov (United States)

    Khang, Tsung Fei; Soo, Oi Yoon Michelle; Tan, Wooi Boon; Lim, Lee Hong Susan

    2016-01-01

    Background. Anchors are one of the important attachment appendages for monogenean parasites. Common descent and evolutionary processes have left their mark on anchor morphometry, in the form of patterns of shape and size variation useful for systematic and evolutionary studies. When combined with morphological and molecular data, analysis of anchor morphometry can potentially answer a wide range of biological questions. Materials and Methods. We used data from anchor morphometry, body size and morphology of 13 Ligophorus (Monogenea: Ancyrocephalidae) species infecting two marine mugilid (Teleostei: Mugilidae) fish hosts: Moolgarda buchanani (Bleeker) and Liza subviridis (Valenciennes) from Malaysia. Anchor shape and size data (n = 530) were generated using methods of geometric morphometrics. We used 28S rRNA, 18S rRNA, and ITS1 sequence data to infer a maximum likelihood phylogeny. We discriminated species using principal component and cluster analysis of shape data. Adams's K mult was used to detect phylogenetic signal in anchor shape. Phylogeny-correlated size and shape changes were investigated using continuous character mapping and directional statistics, respectively. We assessed morphological constraints in anchor morphometry using phylogenetic regression of anchor shape against body size and anchor size. Anchor morphological integration was studied using partial least squares method. The association between copulatory organ morphology and anchor shape and size in phylomorphospace was used to test the Rohde-Hobbs hypothesis. We created monogeneaGM, a new R package that integrates analyses of monogenean anchor geometric morphometric data with morphological and phylogenetic data. Results. We discriminated 12 of the 13 Ligophorus species using anchor shape data. Significant phylogenetic signal was detected in anchor shape. Thus, we discovered new morphological characters based on anchor shaft shape, the length between the inner root point and the outer root

  1. Anchor Stress Checking of Security Injection Tank

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    The intention of the calculating is to check the anchor stresses of the security injection tank to know whether the stress is satisfied the code requirements on the basis of all the reaction forces gained in the static, seismic and thermal stress results.

  2. Stone anchors from Minicoy Island, Lakshadweep, India

    Digital Repository Service at National Institute of Oceanography (India)

    Tripati, S.

    at Androth, Kadmat, Kavaratti and Minicoy. In addition to these finds, in recent past an Indo-Arabian type of stone anchor has come to lime light at the Jama Mosque of Funhilol of Minicoy. In this paper an attempt has been made to describe the Indo...

  3. Predicting Anchor Links between Heterogeneous Social Networks

    CERN Document Server

    Sajadmanesh, Sina; Khodadadi, Ali

    2016-01-01

    People usually get involved in multiple social networks to enjoy new services or to fulfill their needs. Many new social networks try to attract users of other existing networks to increase the number of their users. Once a user (called source user) of a social network (called source network) joins a new social network (called target network), a new inter-network link (called anchor link) is formed between the source and target networks. In this paper, we concentrated on predicting the formation of such anchor links between heterogeneous social networks. Unlike conventional link prediction problems in which the formation of a link between two existing users within a single network is predicted, in anchor link prediction, the target user is missing and will be added to the target network once the anchor link is created. To solve this problem, we use meta-paths as a powerful tool for utilizing heterogeneous information in both the source and target networks. To this end, we propose an effective general meta-pat...

  4. Influence of Anchoring on Burial Depth of Submarine Pipelines

    Science.gov (United States)

    Zhuang, Yuan; Li, Yang; Su, Wei

    2016-01-01

    Since the beginning of the twenty-first century, there has been widespread construction of submarine oil-gas transmission pipelines due to an increase in offshore oil exploration. Vessel anchoring operations are causing more damage to submarine pipelines due to shipping transportation also increasing. Therefore, it is essential that the influence of anchoring on the required burial depth of submarine pipelines is determined. In this paper, mathematical models for ordinary anchoring and emergency anchoring have been established to derive an anchor impact energy equation for each condition. The required effective burial depth for submarine pipelines has then been calculated via an energy absorption equation for the protection layer covering the submarine pipelines. Finally, the results of the model calculation have been verified by accident case analysis, and the impact of the anchoring height, anchoring water depth and the anchor weight on the required burial depth of submarine pipelines has been further analyzed. PMID:27166952

  5. Influence of Anchoring on Burial Depth of Submarine Pipelines.

    Science.gov (United States)

    Zhuang, Yuan; Li, Yang; Su, Wei

    2016-01-01

    Since the beginning of the twenty-first century, there has been widespread construction of submarine oil-gas transmission pipelines due to an increase in offshore oil exploration. Vessel anchoring operations are causing more damage to submarine pipelines due to shipping transportation also increasing. Therefore, it is essential that the influence of anchoring on the required burial depth of submarine pipelines is determined. In this paper, mathematical models for ordinary anchoring and emergency anchoring have been established to derive an anchor impact energy equation for each condition. The required effective burial depth for submarine pipelines has then been calculated via an energy absorption equation for the protection layer covering the submarine pipelines. Finally, the results of the model calculation have been verified by accident case analysis, and the impact of the anchoring height, anchoring water depth and the anchor weight on the required burial depth of submarine pipelines has been further analyzed. PMID:27166952

  6. The Effect of Molecular Anchoring and Curvature on Confined Liquid Crystals

    Science.gov (United States)

    Ondris-Crawford, Renate Johanna

    Nematic liquid crystals confined to curved geometries exhibit unique elastic and anchoring properties. One result of this study was the first simultaneous measurement of the azimuthal (W_phi) and polar (W_theta) anchoring strength and the saddle-splay surface elastic constant K_{24}. The technique confined 4^'-pentyl-4 -cyanobiphenyl (5CB) to submicrometer polyimide treated cylindrical cavities of polycarbonate (Nuclepore) membranes with concentric tangential anchoring conditions for deuterium nuclear magnetic resonance studies. A structural transition upon increasing cavity radius from a planar-bipolar (PB, R 0.5 mu m) structure resulted in the measurement of W _theta and W_phi (comparable in these systems), and of K _{24}/K. The effect of the bend elastic constant K _{33} on the escaped nematic director -field of 4^'-octyl-cyanobiphenyl (8CB) in the submicrometer cavities of Nuclepore membranes is significant near the nematic-smectic A transition. The project encompassed monitoring the anchoring angle, measuring the defect density, and estimating the values for W _theta and K_{24 }/K. The lack of pretransitional smectic layering was attributed to the roughness of the cavity wall. The effect of surface treatments on the nematic structures in the submicrometer cavities of alumina (Anopore) membranes was systematically studied by treating the cavity walls with aliphatic acids (C_{n} H_{2n+1}-COOH) of varying carbon number, n. A configuration transition upon decreasing n from a planar-polar (PP, n>7) to a parallel-axial (PA, n<7) structure indicated a discontinuous anchoring transition from homeotropic to planar anchoring at n = 7. Stable nematic director-fields of chiral nematics in Anopore membranes revealed a structural transition from a PA to a twisted PB (TPB) structure as the percentage of chiral additive increased. The TPB structure is the same as the PB structure in-plane, but the symmetry axis twists along the cylinder axis to accommodate the intrinsic twist

  7. Stone anchors of India: Findings, classification and significance.

    Digital Repository Service at National Institute of Oceanography (India)

    Tripati, S.

    Honolulu, Hawaii, May 12-16, 2014, Vol. 2: 973-986 973 Stone anchors of India: Findings, Classification and Significance Sila Tripati CSIR-National Institute of Oceanography, Dona Paula, Goa 403 004, India Email: sila@nio.org Abstract Various.... The making of anchors from the hero stones indicates their alternative use (Sila Tripati and Patnaik, 2008). Classification Stone anchors are classified according to character, shape and region. In general stone anchors have been classified...

  8. Susceptibility to anchoring effects: How openness-to-experience influences responses to anchoring cues

    OpenAIRE

    Todd McElroy; Keith Dowd

    2007-01-01

    Previous research on anchoring has shown this heuristic to be a very robust psychological phenomenon ubiquitous across many domains of human judgment and decision-making. Despite the prevalence of anchoring effects, researchers have only recently begun to investigate the underlying factors responsible for how and in what ways a person is susceptible to them. This paper examines how one such factor, the Big-Five personality trait of openness-to-experience, influences the effect of previously p...

  9. Technical Note: Drifting vs. anchored flux chambers for measuring greenhouse gas emissions from running waters

    Directory of Open Access Journals (Sweden)

    A. Lorke

    2015-09-01

    Full Text Available Stream networks were recently discovered as major but poorly constrained natural greenhouse gas (GHG sources. A fundamental problem is that several measurement approaches have been used without cross comparisons. Flux chambers represent a potentially powerful methodological approach if robust and reliable ways to use chambers on running water can be defined. Here we compare the use of anchored and freely drifting chambers on various streams having different flow velocities. The study clearly shows that (1 drifting chambers have a very small impact on the water turbulence under the chamber and thus generate more reliable fluxes, (2 anchored chambers enhance turbulence under the chambers and thus elevate fluxes, (3 the bias of the anchored chambers greatly depends on chamber design and sampling conditions, and (4 there is a promising method to reduce the bias from anchored chambers by using a flexible plastic foil seal to the water surface rather than having rigid chamber walls penetrating into the water. Altogether, these results provide novel guidance on how to apply flux chambers in running water, which will have important consequences for measurements to constrain the global GHG balances.

  10. How curved membranes recruit amphipathic helices and protein anchoring motifs

    DEFF Research Database (Denmark)

    Hatzakis, Nikos; Bhatia, Vikram Kjøller; Larsen, Jannik;

    2009-01-01

    : membrane-anchored proteins. The fact that unrelated structural motifs such as alpha-helices and alkyl chains sense MC led us to propose that MC sensing is a generic property of curved membranes rather than a property of the anchoring molecules. We therefore anticipate that MC will promote the...... redistribution of proteins that are anchored in membranes through other types of hydrophobic moieties....

  11. 33 CFR 401.14 - Anchor marking buoys.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Anchor marking buoys. 401.14 Section 401.14 Navigation and Navigable Waters SAINT LAWRENCE SEAWAY DEVELOPMENT CORPORATION, DEPARTMENT OF TRANSPORTATION SEAWAY REGULATIONS AND RULES Regulations Condition of Vessels § 401.14 Anchor marking buoys. A highly visible anchor marking...

  12. Students' Anchoring Predisposition: An Illustration from Spring Training Baseball

    Science.gov (United States)

    Mohrweis, Lawrence C.

    2014-01-01

    The anchoring tendency results when decision makers anchor on initial values and then make final assessments that are adjusted insufficiently away from the initial values. The professional literature recognizes that auditors often risk falling into the judgment trap of anchoring and adjusting (Ranzilla et al., 2011). Students may also be unaware…

  13. Geodesic defect anchoring on nematic shells.

    Science.gov (United States)

    Mirantsev, Leonid V; Sonnet, André M; Virga, Epifanio G

    2012-08-01

    Nematic shells are colloidal particles coated with nematic liquid crystal molecules, which may freely glide and rotate on the colloid's surface while keeping their long axis on the local tangent plane. Molecular dynamics simulations on a nanoscopic spherical shell indicate that under appropriate adhesion conditions for the molecules on the equator, the equilibrium nematic texture exhibits at each pole a pair of +1/2 defects so close to one another to be treated as one +1 defect. Spirals connect the polar defects, though the continuum limit of the interaction potential would not feature any elastic anisotropy. A molecular averaging justifies an anchoring defect energy that feels the geodesics emanating from the defect. All our observations are explained by such a geodesic anchoring, which vanishes on flat manifolds. PMID:23005713

  14. Recent Study of Drag Embedment Plate Anchors in China

    Institute of Scientific and Technical Information of China (English)

    Haixiao Liu

    2012-01-01

    Experimental and theoretical studies of drag embedment plate anchors recently carried out in Tianjin University are summarized in this research paper,which involve a series of important topics relevant to the study of drag anchors.The techniques for measuring the trajectory and movement direction of drag anchors in soils,the techniques for measuring the moving embedment point and reverse catenary shape of the embedded drag line,the penetration mechanism and kinematic behavior of drag anchors,the ultimate embedment depth of drag anchors,the movement direction of the anchor with an arbitrary fluke section,the reverse catenary properties of the embedded drag line,the interactional properties between drag anchor and installation line,the kinematic model of drag anchors in seabed soils,and the analytical method for predicting the anchor trajectory in soils will all be examined.The present work remarkably reduces the uncertainties in design and analysis of drag embedment plate anchors,and is beneficial to improving the application of this new type of drag anchor in offshore engineering.

  15. Anchoring in a novel bimanual coordination pattern.

    Science.gov (United States)

    Maslovat, Dana; Lam, Melanie Y; Brunke, Kirstin M; Chua, Romeo; Franks, Ian M

    2009-02-01

    Anchoring in cyclical movements has been defined as regions of reduced spatial or temporal variability [Beek, P. J. (1989). Juggling dynamics. PhD thesis. Amsterdam: Free University Press] that are typically found at movement reversal points. For in-phase and anti-phase movements, synchronizing reversal points with a metronome pulse has resulted in decreased anchor point variability and increased pattern stability [Byblow, W. D., Carson, R. G., & Goodman, D. (1994). Expressions of asymmetries and anchoring in bimanual coordination. Human Movement Science, 13, 3-28; Fink, P. W., Foo, P., Jirsa, V. K., & Kelso, J. A. S. (2000). Local and global stabilization of coordination by sensory information. Experimental Brain Research, 134, 9-20]. The present experiment examined anchoring during acquisition, retention, and transfer of a 90 degrees phase-offset continuous bimanual coordination pattern (whereby the right limb lags the left limb by one quarter cycle), involving horizontal flexion about the elbow. Three metronome synchronization strategies were imposed: participants either synchronized maximal flexion of the right arm (i.e., single metronome), both flexion and extension of the right arm (i.e., double metronome within-limb), or flexion of each arm (i.e., double metronome between-limb) to an auditory metronome. In contrast to simpler in-phase and anti-phase movements, synchronization of additional reversal points to the metronome did not reduce reversal point variability or increase pattern stability. Furthermore, practicing under different metronome synchronization strategies did not appear to have a significant effect on the rate of acquisition of the pattern. PMID:18842313

  16. Molecular Conductance: Chemical Trends of Anchoring Groups

    OpenAIRE

    Ke, San-Huang; Baranger, Harold U.; Yang, Weitao

    2004-01-01

    Combining density functional theory calculations for molecular electronic structure with a Green function method for electron transport, we calculate from first principles the molecular conductance of benzene connected to two Au leads through different anchoring atoms -- S, Se, and Te. The relaxed atomic structure of the contact, different lead orientations, and different adsorption sites are fully considered. We find that the molecule-lead coupling, electron transfer, and conductance all dep...

  17. Anchor Toolkit - a secure mobile agent system

    OpenAIRE

    Mudumbai, Srilekha S.; Johnston, William; Essiari, Abdelilah

    2008-01-01

    Mobile agent technology facilitates intelligent operation in software systems with less human interaction. Major challenge to deployment of mobile agents include secure transmission of agents and preventing unauthorized access to resources between interacting systems, as either hosts, or agents, or both can act maliciously. The Anchor toolkit, designed by LBNL, handles the transmission and secure management of mobile agents in a heterogeneous distributed computing environment. It provide...

  18. Anchoring Heuristic and the Equity Premium Puzzle

    OpenAIRE

    Siddiqi, Hammad

    2015-01-01

    What happens when the anchoring and adjustment heuristic of Tversky and Kahneman (1974) is incorporated in the standard consumption-based capital asset pricing model (CCAPM)? The surprising finding is that it not only resolves the high equity-premium and low risk-free rate puzzles with a low risk-aversion coefficient, but also provides a unified framework for understanding countercyclical equity-premium, excess volatility, size, value, and momentum effects, and abnormal returns and volatiliti...

  19. Characterization of the Sclerotinia sclerotiorum cell wall proteome.

    Science.gov (United States)

    Liu, Longzhou; Free, Stephen J

    2016-08-01

    We used a proteomic analysis to identify cell wall proteins released from Sclerotinia sclerotiorum hyphal and sclerotial cell walls via a trifluoromethanesulfonic acid (TFMS) digestion. Cell walls from hyphae grown in Vogel's glucose medium (a synthetic medium lacking plant materials), from hyphae grown in potato dextrose broth and from sclerotia produced on potato dextrose agar were used in the analysis. Under the conditions used, TFMS digests the glycosidic linkages in the cell walls to release intact cell wall proteins. The analysis identified 24 glycosylphosphatidylinositol (GPI)-anchored cell wall proteins and 30 non-GPI-anchored cell wall proteins. We found that the cell walls contained an array of cell wall biosynthetic enzymes similar to those found in the cell walls of other fungi. When comparing the proteins in hyphal cell walls grown in potato dextrose broth with those in hyphal cell walls grown in the absence of plant material, it was found that a core group of cell wall biosynthetic proteins and some proteins associated with pathogenicity (secreted cellulases, pectin lyases, glucosidases and proteases) were expressed in both types of hyphae. The hyphae grown in potato dextrose broth contained a number of additional proteins (laccases, oxalate decarboxylase, peroxidase, polysaccharide deacetylase and several proteins unique to Sclerotinia and Botrytis) that might facilitate growth on a plant host. A comparison of the proteins in the sclerotial cell wall with the proteins in the hyphal cell wall demonstrated that sclerotia formation is not marked by a major shift in the composition of cell wall protein. We found that the S. sclerotiorum cell walls contained 11 cell wall proteins that were encoded only in Sclerotinia and Botrytis genomes. PMID:26661933

  20. FragAnchor: A Large-Scale Predictor of Glycosylphosphatidylinositol Anchors in Eukaryote Protein Sequences by Qualitative Scoring

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    A glycosylphosphatidylinositol (GPI) anchor is a common but complex C-terminal post-translational modification of extracellular proteins in eukaryotes. Here we investigate the problem of correctly annotating GPI-anchored proteins for the growing number of sequences in public databases. We developed a computational system, called FragAnchor, based on the tandem use of a neural network (NN) and a hidden Markov model (HMM). Firstly, NN selects potential GPI-anchored proteins in a dataset, then HMM parses these potential GPI signals and refines the prediction by qualitative scoring. FragAnchor correctly predicted 91% of all the GPI-anchored proteins annotated in the Swiss-Prot database.In a large-scale analysis of 29 eukaryote proteomes, FragAnchor predicted that the percentage of highly probable GPI-anchored proteins is between 0.21% and 2.01%. The distinctive feature of FragAnchor, compared with other systems,is that it targets only the C-terminus of a protein, making it less sensitive to the background noise found in databases and possible incomplete protein sequences. Moreover, FragAnchor can be used to predict GPI-anchored proteins in all eukaryotes. Finally, by using qualitative scoring, the predictions combine both sensitivity and information content. The predictor is publicly available at http: // navet. ics. hawaii.edu/~fraganchor/NNHMM/NNHMM.html.

  1. Strengthening of existing concrete dams using post-tensioned anchors: a state-of-the-art review

    International Nuclear Information System (INIS)

    Many old dams are in need of strengthening and rehabilitation as a result of aging, deterioration, deficiencies in design and construction, and more stringent safety standards. Post-tensioned anchors are the most practical and cost-effective method of strengthening existing dams subjected to direct tension, sliding, overturning and seismic loading. Post-tensioning technique requires minimum demolition, has only a minor impact on the dam, and is relatively inexpensive using a small number of anchors. About 60 case histories of concrete dams strengthened by post-tensioned anchors were reviewed. The reasons for strengthening were analyzed, and the general design, construction, drilling, grouting, testing, and performance of post-tensioned anchors were outlined. Principal reasons for using post-tensioned anchors were: (1) increasing spillway capacity and dam stability, (2) raising dam height for great storage, (3) upgrading dams to new safety standards, (4) remedying the deficiencies in design, (5) stabilizing concrete cracks, (6) strengthening dam abutments, and (7) reinforcing lock walls or building blocks into coffer dams. 72 refs., 12 figs., 6 tabs

  2. Dynamic performance of concrete undercut anchors for Nuclear Power Plants

    International Nuclear Information System (INIS)

    Graphical abstract: - Highlights: • Behavior of undercut anchors under dynamic actions simulating earthquakes. • First high frequency load and crack cycling tests on installed concrete anchors ever. • Comprehensive review of anchor qualification for Nuclear Power Plants. - Abstract: Post-installed anchors are widely used for structural and nonstructural connections to concrete. In many countries, concrete anchors used for Nuclear Power Plants have to be qualified to ensure reliable behavior even under extreme conditions. The tests required for qualification of concrete anchors are carried out at quasi-static loading rates well below the rates to be expected for dynamic actions deriving from earthquakes, airplane impacts or explosions. To investigate potentially beneficial effects of high loading rates and cycling frequencies, performance tests on installed undercut anchors were conducted. After introductory notes on anchor technology and a comprehensive literature review, this paper discusses the qualification of anchors for Nuclear Power Plants and the testing carried out to quantify experimentally the effects of dynamic actions on the load–displacement behavior of undercut anchors

  3. Analysis of Glenoid Inter-anchor Distance with an All-Suture Anchor System

    Science.gov (United States)

    Kramer, Jonathan; Robinson, Sean; Dutton, Pascual; Dickinson, Ephraim; Rodriguez, John Paul; Camisa, William; Leasure, Jeremi M.; Montgomery, William H.

    2016-01-01

    Objectives: Arthroscopic shoulder stabilization using suture anchors are commonly used techniques. More recently developed all-suture systems employ smaller diameter anchors, which increase repair contact area and allow greater placement density on narrow surfaces such as the glenoid. Our goal is investigate the strength characteristics of various inter-anchor distances in a human glenoid model. Methods: Twelve fresh-frozen human cadaveric glenoids were potted after the labrum was excised. The glenoids were then implanted with 1.4 mm all-suture anchors (Juggerknot, Biomet, Warsaw, IN) at varying inter-anchor distances. Anchors were implanted adjacent to one another or at 2 mm, 3 mm, or 5 mm distances using a template with pre-drilled holes. The glenoids were then underwent single cycle pullout testing using a test frame (Instron 8521, Instron Inc., Norwood, MA). A 5 N preload was applied to the construct and the actuator was driven away from the shoulder at a rate of 12.5mm/s as seen in Figure 1. Force and displacement were collected from the test frame actuator at a rate of 500 Hz. The primary outcomes were failure strength and stiffness. Stiffness was calculated from the initial linear region of the force displacement curve. Failure strength was defined as the first local maximum inflection point in the force displacement curve. Results: During load to fail testing, all but three of the specimens had both anchors pull out of the glenoid. The other mode of failure included one or both of the sutures failing. Stiffness was 13.52 ± 3.8, 17.97 ± 5.02, 17.59 ± 4.65 and 18.95 ± 4.67 N/mm for the adjacent, 2 mm, 3 mm and 5 mm treatment groups as shown Table 1. The adjacent group had a significantly lower stiffness compared to the other treatment groups. Failure strength was 48.68 ± 20.64, 76.16 ± 23.78, 73.19 ± 35.83 and 87.04 ± 34.67 N for the adjacent, 2 mm, 3 mm and 5 mm treatment groups as shown in Table 1. The adjacent group had a significantly lower

  4. Ambiguous walls

    DEFF Research Database (Denmark)

    Mody, Astrid

    2012-01-01

    The introduction of Light Emitting Diodes (LEDs) in the built environment has encouraged myriad applications, often embedded in surfaces as an integrated part of the architecture. Thus the wall as responsive luminous skin is becoming, if not common, at least familiar. Taking into account how wall...

  5. Anchoring of FRET Sensors-A Requirement for Spatiotemporal Resolution.

    Science.gov (United States)

    Ivanova, Elena V; Figueroa, Ricardo A; Gatsinzi, Tom; Hallberg, Einar; Iverfeldt, Kerstin

    2016-01-01

    FRET biosensors have become a routine tool for investigating mechanisms and components of cell signaling. Strategies for improving them for particular applications are continuously sought. One important aspect to consider when designing FRET probes is the dynamic distribution and propagation of signals within living cells. We have addressed this issue by directly comparing an anchored (taFS) to a non-anchored (naFS) cleavable FRET sensor. We chose a microtubule-associated protein tau as an anchor, as microtubules are abundant throughout the cytosol of cells. We show that tau-anchored FRET sensors are concentrated at the cytoskeleton and enriched in the neurite-like processes of cells, providing high intensity of the total signal. In addition, anchoring limits the diffusion of the sensor, enabling spatiotemporally resolved monitoring of subcellular variations in enzyme activity. Thus, anchoring is an important aspect to consider when designing FRET sensors for deeper understanding of cell signaling. PMID:27196902

  6. Adsorption phenomena and anchoring energy in nematic liquid crystals

    CERN Document Server

    Barbero, Giovanni

    2005-01-01

    Despite the large quantity of phenomenological information concerning the bulk properties of nematic phase liquid crystals, little is understood about the origin of the surface energy, particularly the surface, interfacial, and anchoring properties of liquid crystals that affect the performance of liquid crystal devices. Self-contained and unique, Adsorption Phenomena and Anchoring Energy in Nematic Liquid Crystals provides an account of new and established results spanning three decades of research into the problems of anchoring energy and adsorption phenomena in liquid crystals.The book contains a detailed discussion of the origin and possible sources of anchoring energy in nematic liquid crystals, emphasizing the dielectric contribution to the anchoring energy in particular. Beginning with fundamental surface and anchoring properties of liquid crystals and the definition of the nematic phase, the authors explain how selective ion adsorption, dielectric energy density, thickness dependence, and bias voltage...

  7. Anchor Toolkit - a secure mobile agent system

    Energy Technology Data Exchange (ETDEWEB)

    Mudumbai, Srilekha S.; Johnston, William; Essiari, Abdelilah

    1999-05-19

    Mobile agent technology facilitates intelligent operation insoftware systems with less human interaction. Major challenge todeployment of mobile agents include secure transmission of agents andpreventing unauthorized access to resources between interacting systems,as either hosts, or agents, or both can act maliciously. The Anchortoolkit, designed by LBNL, handles the transmission and secure managementof mobile agents in a heterogeneous distributed computing environment. Itprovides users with the option of incorporating their security managers.This paper concentrates on the architecture, features, access control anddeployment of Anchor toolkit. Application of this toolkit in a securedistributed CVS environment is discussed as a case study.

  8. Starting point anchoring effects in choice experiments

    DEFF Research Database (Denmark)

    Ladenburg, Jacob; Olsen, Søren Bøye

    Anchoring is acknowledged as a potential source of considerable bias in Dichotomous Choice Contingent Valuation studies. Recently, another stated preference method known as Choice Experiments has gained in popularity as well as the number of applied studies. However, as the elicitation of...... subjectivity in the present study is gender dependent, pointing towards, that female respondents are prone to be affected by the price levels employed. Male respondents, on the other hand, are not sensitive towards these prices levels. Overall, this implicates that female respondents, when employing a low...

  9. The bone-anchored hearing aid

    DEFF Research Database (Denmark)

    Foghsgaard, Søren

    2014-01-01

    The bone-anchored hearing aid (Baha) was introduced in 1977 by Tjellström and colleagues and has now been used clinically for over 30 years. Generally, the outcomes are good, and several studies have shown improved audiological- and quality of life outcomes. The principle of the Baha is, that sound...... vibrations are led directly to the inner ear via the mastoid bone, bypassing the middle ear. This is achieved via an osseointegrated implant and a skin-penetrating abutment. Studies report high success rates and a majority of complications as typically minor in nature....

  10. Nominal Anchor Exchange Rate Policies as a Domestic Distortion

    OpenAIRE

    Anne O. Krueger

    1997-01-01

    This paper analyzes a nominal anchor exchange rate policy as a domestic distortion, in the tradition of international trade theory. It is shown that, in addition to the problems of sustainability and exit pinpointed in the exchange rate literature, a nominal anchor exchange rate policy, while in force, drives a wedge between the domestic and the international intertemporal marginal rates of substitution. The welfare cost of the Mexican use of the nominal anchor exchange rate policy prior to D...

  11. The impact of anchoring bias in the UK equity market

    OpenAIRE

    Koskinen, Matti

    2013-01-01

    PURPOSE OF THE STUDY The purpose of this thesis is to study how the anchoring bias, a cognitive bias, affects equity analysts' forecasts and what kind of implications this bias has for investors and managers of listed companies in the UK stock market. I test whether industry median forecast earnings per share can work as an anchor when analysts are estimating companies' future earnings and how this potential anchoring affects forecast errors, future stock returns, earnings surprises and s...

  12. Decoding Cytoskeleton-Anchored and Non-Anchored Receptors from Single-Cell Adhesion Force Data.

    Science.gov (United States)

    Sariisik, Ediz; Popov, Cvetan; Müller, Jochen P; Docheva, Denitsa; Clausen-Schaumann, Hauke; Benoit, Martin

    2015-10-01

    Complementary to parameters established for cell-adhesion force curve analysis, we evaluated the slope before a force step together with the distance from the surface at which the step occurs and visualized the result in a two-dimensional density plot. This new tool allows detachment steps of long membrane tethers to be distinguished from shorter jumplike force steps, which are typical for cytoskeleton-anchored bonds. A prostate cancer cell line (PC3) immobilized on an atomic-force-microscopy sensor interacted with three different substrates: collagen-I (Col-I), bovine serum albumin, and a monolayer of bone marrow-derived stem cells (SCP1). To address PC3 cells' predominant Col-I binding molecules, an antibody-blocking β1-integrin was used. Untreated PC3 cells on Col-I or SCP1 cells, which express Col-I, predominantly showed jumps in their force curves, while PC3 cells on bovine-serum-albumin- and antibody-treated PC3 cells showed long membrane tethers. The probability density plots thus revealed that β1-integrin-specific interactions are predominately anchored to the cytoskeleton, while the nonspecific interactions are mainly membrane-anchored. Experiments with latrunculin-A-treated PC3 cells corroborated these observations. The plots thus reveal details of the anchoring of bonds to the cell and provide a better understanding of receptor-ligand interactions. PMID:26445433

  13. Illusion of Relevance: Anchoring in Economic and Financial Knowledge

    Directory of Open Access Journals (Sweden)

    Andrey Kudryavtse

    2010-12-01

    Full Text Available Contemporary research documents various psychological aspects of economic thought and decision-making. The main goal of our study is to analyze the role of the anchoring (bias(Tversky and Kahneman, 1974 in perceiving economic and financial information, and, in particular, the effect of perceived relevance of the anchors on the degree of the bias. Anchoring bias refers to people's tendency to form their estimates for different categories, starting from a particular available, and often irrelevant, value and insufficiently adjusting their final judgments from this starting value. We carry out an experiment involving a group of MBA students, asking them to recall a number of recent economic and financial indicators (stock and bond market index returns, rates of inflation, currency exchange rates, etc., with half of the participants receiving actual information about some unrelated indicators (anchors, before answering the questions. We document that significant anchoring bias is exhibited, on average, for each of our experimental questions and by vast majority of the participants, the degree of the bias being higher for women and older participants. Furthermore, in the context of the effect of anchors' perceived relevance, we find that people exhibit significantly stronger bias in cases when the anchor is presented as a similar category. Our findings indicate that if, at least at the first glance, an anchor bears some similarity to the target question, then the resulting answer may be more assimilated towards the anchor

  14. Ultimate limit state design of sheet pile walls by finite elements and nonlinear programming

    DEFF Research Database (Denmark)

    Krabbenhøft, Kristian; Damkilde, Lars; Krabbenhøft, Sven

    2005-01-01

    The design of sheet pile walls by lower bound limit analysis is considered. The design problem involves the determination of the necessary yield moment of the wall, the wall depth and the anchor force such that the structure is able to sustain the given loads. This problem is formulated as a nonl......The design of sheet pile walls by lower bound limit analysis is considered. The design problem involves the determination of the necessary yield moment of the wall, the wall depth and the anchor force such that the structure is able to sustain the given loads. This problem is formulated...... as a nonlinear programming problem where the yield moment of the wall is minimized subject to equilibrium and yield conditions. The finite element discretization used enables exact fulfillment of these conditions and thus, according to the lower bound theorem, the solutions are safe....

  15. Ultimate Limit State Design Of Sheet Pile Walls By Finite Elements And Nonlinear Programming

    DEFF Research Database (Denmark)

    Krabbenhøft, Kristian; Damkilde, Lars; Krabbenhøft, Sven

    2005-01-01

    The design of sheet pile walls by lower bound limit analysis is considered. The design problem involves the determination of the necessary yield moment of the wall, the wall depth and the anchor force such that the structure is able to sustain the given loads. This problem is formulated as a nonl......The design of sheet pile walls by lower bound limit analysis is considered. The design problem involves the determination of the necessary yield moment of the wall, the wall depth and the anchor force such that the structure is able to sustain the given loads. This problem is formulated...... as a nonlinear programming problem where the yield moment of the wall is minimized subject to equilibrium and yield conditions. The finite element discretization used enables exact fulfillment of these conditions and thus, according to the lower bound theorem, the solutions are safe...

  16. Bidimensional distortion in ferroelectric liquid crystals with strong anchoring in bookshelf geometry

    Indian Academy of Sciences (India)

    S Ponti; M Becchi; A Strigazzi; S Torgova

    2003-08-01

    In the last decade, it has been experimentally found that in certain conditions a periodic domain pattern arises in ferroelectric liquid crystals (FLC) in bookshelf geometry. Such a periodic texture appears after switching-off an external electric field, even in strong anchoring conditions. It has a static character and is bidimensional, being dependent on directions normal to both the smectic planes and the cell plates. Here a new model explaining this phenomenon is proposed, valid in the case of FLC with strong anchoring. The model is based on the coupling between the spontaneous polarization field in the first semi-period of its modulation along the cell plates and the same field in the second semi-period. This coupling competes with the FLC medium elasticity and is trapped by the anchoring. According to our model, in the ferroelectric state the biperiodic texture is favored by increasing the values of spontaneous polarization. The critical value of the spontaneous polarization for which the undeformed state becomes unstable is found. It is shown to be proportional to the square root of the ratio between the FLC elastic constant and the cell thickness. Moreover, it is inversely proportional to the sinus of the pre-tilt angle with respect to the cell walls.

  17. Increasing pull-out capacity of granular pile anchors in expansive soils using base geosynthetics

    Energy Technology Data Exchange (ETDEWEB)

    Phani Kumar, B.R.; Ramachandra Rao, N. [JNTU College of Engineering, Kakinada (India)

    2000-08-04

    Expansive soils react to changes in moisture regimes by swelling and shrinking. As a result civil engineering structures such as foundations, retaining walls, pavements, canal beds and linings built on them can suffer damage. Granular pile anchors are new and effective ways to resist the uplift pressure exerted on the foundation by swelling expansive soil. The foundation of the anchors is cemented at the bottom of a granular pile to a plate using a steel rod which renders the granular pile tension-resistant and allows it to resist the uplift force. This resistance depends mostly on the shear parameters of the pile-soil interface and the lateral swelling pressure of the soil. Placing a base geosynthetic above the anchor can further increase the resistance to uplift. The increase in resistance results from the friction between the geosynthetic and the confining media when the uplift load acts on the pile and the geosynthetic moves along with the pile. The effects of these parameters on pull-out load, rate of heave, and relative ground movement near the pile surface were discussed. 11 refs., 3 tabs., 14 figs.

  18. Seismic response of unanchored and partially anchored liquid-storage tanks. Final report

    International Nuclear Information System (INIS)

    Ground-mounted vertical storage tanks are important components of nuclear plant safety systems. A systematic study is made of the principal effects of base uplifting on the seismic response of laterally excited, unanchored and partially anchored cylindrical liquid-storage tanks. The study consists of two parts: the first deals with the static uplifting resistance of the flexible base plate, and the second deals with the dynamic response of the uplifting system. An insight into the behavior of the uplifting base plate is first gained with the help of a prismatic beam solution. In Section 2, the solution is implemented exactly, whereas in Section 3 it is implemented approximately by use of the Ritz energy procedure. Solutions are next presented for axisymmetrically and asymmetrically uplifted base plate of tanks, in Section 4. For the axisymmetric case the solution is implemented exactly, as well as approximately by modeling the plate by a series of semiinfinite prismatic beams. The accuracy of the latter approach is confirmed by comparing its predictions with those of the former. In Section 5, a highly efficient and rational method is presented for the dynamic response analysis of uplifting tanks. Both unanchored tanks and partially anchored tanks, for which the number of anchor bolts at the base is insufficient to ensure full fixity, are considered. It is shown that base uplifting may reduce significantly the hydrodynamic pressures, but these reductions may be associated with increased axial compressive stresses in the tank wall and large plastic rotations at the plate-shell junction. For partially anchored tanks, energy loss due to bolt yielding is found to be small

  19. 30 CFR 57.9311 - Anchoring stationary sizing devices.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Anchoring stationary sizing devices. 57.9311 Section 57.9311 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND... Dumping Sites § 57.9311 Anchoring stationary sizing devices. Grizzlies and other stationary sizing...

  20. 30 CFR 56.9311 - Anchoring stationary sizing devices.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Anchoring stationary sizing devices. 56.9311 Section 56.9311 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND... Dumping Sites § 56.9311 Anchoring stationary sizing devices. Grizzlies and other stationary sizing...

  1. Understanding Rasch Measurement: Partial Credit Model and Pivot Anchoring.

    Science.gov (United States)

    Bode, Rita K.

    2001-01-01

    Describes the Rasch measurement partial credit model, what it is, how it differs from other Rasch models, and when and how to use it. Also describes the calibration of instruments with increasingly complex items. Explains pivot anchoring and illustrates its use and describes the effect of pivot anchoring on step calibrations, item hierarchy, and…

  2. Breaking anchored droplets in a microfluidic Hele-Shaw cell

    CERN Document Server

    Amselem, Gabriel; Gallaire, François; Baroud, Charles N

    2015-01-01

    We study microfluidic self digitization in Hele-Shaw cells using pancake droplets anchored to surface tension traps. We show that above a critical flow rate, large anchored droplets break up to form two daughter droplets, one of which remains in the anchor. Below the critical flow velocity for breakup the shape of the anchored drop is given by an elastica equation that depends on the capillary number of the outer fluid. As the velocity crosses the critical value, the equation stops admitting a solution that satisfies the boundary conditions; the drop breaks up in spite of the neck still having finite width. A similar breaking event also takes place between the holes of an array of anchors, which we use to produce a 2D array of stationary drops in situ.

  3. Study on range interval distance of prestressed anchor bars using update backpropagation neural network

    Institute of Scientific and Technical Information of China (English)

    WU Shun-chuan(吴顺川); ZHANG You-pa(张友葩); GAO Yong-tao(高永涛)

    2003-01-01

    Taking the practical reinforced engineering of a reinforced soil retaining wall as an example, which located in Shandong Province and set on 104 national highway, the stress-spread behaviors of the anchor bars in the preforced proceeding were tested. According to the test data, and by use of the update backpropagation (BP) algorithm neural network(NN), the test method and it's mechanism were studied by the network, then the learning results show the mean square error(MSE) only at the 2.55% level, and the proof-testing results show the MSE at 4.38% level (the main aim is to build a NN directly from the in-situ test results (the learning phase)). Ipso-facto, the learning and adjustment abilities of the NN permit us to develop the test data, subsequently, 36 test data were acquired from the NN. By use of the provide data, as well as the failure situation and carried loading capacity of the retaining wall, finally, the choice the reasonable range interval distance of prestress cement grouting anchor bars were carried out, and the result was 2 m×2 m.

  4. Estimation of maximum axial force of anchor bolts in consideration of random bolt failures

    International Nuclear Information System (INIS)

    This paper proposes a method for structural reliability analysis of anchor bolts used in the support skirt of a reactor vessel. The method is based on the conservative assumption that a few anchor bolts within the skirt's inner-wall may fail in a random nature. Under the assumption, the maximum axial forces in the intact bolts are estimated. To reflect the uncertainty, random numbers are generated to simulate the possible failed bolts among a total of 60 bolts, which are circumferentially arranged along the inner side of the wall. Then the outcome of failed bolts together with their locations for every 60 bolts is defined as an experiment of a sample. The locations of failed bolt can significantly affect the stress analysis and its random outcomes require an efficient calculation scheme. In this paper we propose a rapid calculation algorithm, thus the direction of bending moment that causes the worst scenario in the stress analysis of bolts for each experiment can be rapidly found. Taking into consideration of design loads, the finite element method is further employed to calculate the maximum axial bolt force of each experiment. After statistical analysis of maximum axial forces from all experiments, the average maximum axial-force interval that the remaining bolts can withstand under a given random condition is estimated with a 95% confidence level. This interval can be used in conjunction with various results of structural integrity assessment to ensure the structural safety and reliability of a nuclear power plant component

  5. Optimal Design of Sheet Pile Wall Embedded in Clay

    Science.gov (United States)

    Das, Manas Ranjan; Das, Sarat Kumar

    2015-09-01

    Sheet pile wall is a type of flexible earth retaining structure used in waterfront offshore structures, river protection work and temporary supports in foundations and excavations. Economy is an essential part of a good engineering design and needs to be considered explicitly in obtaining an optimum section. By considering appropriate embedment depth and sheet pile section it may be possible to achieve better economy. This paper describes optimum design of both cantilever and anchored sheet pile wall penetrating clay using a simple optimization tool Microsoft Excel ® Solver. The detail methodology and its application with examples are presented for cantilever and anchored sheet piles. The effects of soil properties, depth of penetration and variation of ground water table on the optimum design are also discussed. Such a study will help professional while designing the sheet pile wall penetrating clay.

  6. Neurostimulation leads, intrathecal catheters and anchoring devices evolution

    Directory of Open Access Journals (Sweden)

    Laura Demartini

    2015-03-01

    Full Text Available Many scientific studies highlight the usefulness of spinal cord stimulation and intrathecal therapy for the management of chronic pain syndromes resistant to pharmacological or less invasive interventional therapies. One of the possible complications of these techniques, reported in literature, is migration of the lead or catheter; thus the use of an anchoring system is considered mandatory. Every company that produces devices for neurostimulation or neuromodulation provides various anchoring devices evolved over time. In the study, the authors discuss about the most common anchoring devices based on their clinical experience.

  7. Instability of a Biaxial Nematic Liquid Crystal Formed by Homeotropic Anchoring on Surface Grooves

    Institute of Scientific and Technical Information of China (English)

    ZHANG Zhi-Dong; XUAN Li

    2011-01-01

    A method used to treat the elastic distortion of a uniaxial nematic liquid crystal induced by homogeneous anchoring on the surface grooves is generalized to biaxial nematic liquid crystals under the homeotropic anchoring condition.Employing some approximations for the elastic constants,we obtain an additional term in the elastic energy per unit area which depends on the angle between the minor director at infinity and the direction of the grooves,with a period of π/2.This leads to instability on the surface grooves so that two states with crossed minor directors are energetically indistinguishable.Our theoretical study explains why the homeotropic alignment method developed for uniaxial liquid crystals loses efficacy for biaxial nematics.In most liquid crystal devices,the liquid crystals are sandwiched between two substrates coated with alignment layers.In the absence of externally applied fields,the orientation of the liquid crystal in the cell is determined by the anchoring condition of the alignment layer.[1-3] One usually distinguishes three main types of liquid crystalline director alignment near solid walls:homeotropic,homogeneous (or planar) and tilted orientations.Here we study the first of these and consider the biaxial nematic phase,which was observed in lyotropic systems as early as 1980[4] and has been confirmed by deuterium NMR spectroscopy.%A method used to treat the elastic distortion of a uniaxial nematic liquid crystal induced by homogeneous anchoring on the surface grooves is generalized to biaxial nematic liquid crystals under the homeotropic anchoring condition. Employing some approximations for the elastic constants, we obtain an additional term in the elastic energy per unit area which depends on the angle between the minor director at infinity and the direction of the grooves, with a period of π/2. This leads to instability on the surface grooves so that two states with crossed minor directors are energetically indistinguishable. Our

  8. Maxillary sinus perforation by orthodontic anchor screws.

    Science.gov (United States)

    Motoyoshi, Mitsuru; Sanuki-Suzuki, Rina; Uchida, Yasuki; Saiki, Akari; Shimizu, Noriyoshi

    2015-06-01

    To facilitate safe placement of orthodontic anchor screws (miniscrews), we investigated the frequency of maxillary sinus perforation after screw placement and the effect of sinus perforation on screw stability. Maxillary sinus perforations involving 82 miniscrews (diameter, 1.6 mm; length, 8 mm) were evaluated using cone-beam computed tomography. All miniscrews were placed in maxillary alveolar bone between the second premolar and first molar for anchorage for anterior retraction in patients undergoing first premolar extraction. The placement torque and screw mobility of each implant were determined using a torque tester and a Periotest device, and variability in these values in relation to sinus perforation was evaluated. Eight of the 82 miniscrews perforated the maxillary sinus. There was no case of sinusitis in patients with miniscrew perforation and no significant difference in screw mobility or placement torque between perforating and non-perforating miniscrews. The sinus floor was significantly thinner in perforated cases than in non-perforated cases. A sinus floor thickness of 6.0 mm or more is recommended in order to avoid miniscrew perforation of the maxillary sinus. PMID:26062857

  9. Anchored boundary conditions for locally isostatic networks

    Science.gov (United States)

    Theran, Louis; Nixon, Anthony; Ross, Elissa; Sadjadi, Mahdi; Servatius, Brigitte; Thorpe, M. F.

    2015-11-01

    Finite pieces of locally isostatic networks have a large number of floppy modes because of missing constraints at the surface. Here we show that by imposing suitable boundary conditions at the surface the network can be rendered effectively isostatic. We refer to these as anchored boundary conditions. An important example is formed by a two-dimensional network of corner sharing triangles, which is the focus of this paper. Another way of rendering such networks isostatic is by adding an external wire along which all unpinned vertices can slide (sliding boundary conditions). This approach also allows for the incorporation of boundaries associated with internal holes and complex sample geometries, which are illustrated with examples. The recent synthesis of bilayers of vitreous silica has provided impetus for this work. Experimental results from the imaging of finite pieces at the atomic level need such boundary conditions, if the observed structure is to be computer refined so that the interior atoms have the perception of being in an infinite isostatic environment.

  10. Stone anchors from the Okhamandal region, Gujarat Coast, India

    Digital Repository Service at National Institute of Oceanography (India)

    Sundaresh; Gaur, A.S.; Gudigar, P.; Tripati, S.; Vora, K.H.; Bandodkar, S.N.

    Dwarka and Armada yielded a number of stone anchors which suggest that Okhamandal area was major concentration of maritime activities in Saurashtra region in the past. Among these three sites, Bet Dwarka has clear evidence on the settlement of Harappan...

  11. Neurostimulation leads, intrathecal catheters and anchoring devices evolution

    OpenAIRE

    Laura Demartini; Gianluca Conversa; Luciana Armiento; Lucia Angelini; Cesare Bonezzi

    2015-01-01

    Many scientific studies highlight the usefulness of spinal cord stimulation and intrathecal therapy for the management of chronic pain syndromes resistant to pharmacological or less invasive interventional therapies. One of the possible complications of these techniques, reported in literature, is migration of the lead or catheter; thus the use of an anchoring system is considered mandatory. Every company that produces devices for neurostimulation or neuromodulation provides various anchoring...

  12. Monetary sterilization and dual nominal anchors: some Caribbean examples

    OpenAIRE

    Khemraj, Tarron; Pasha, Sukrishnalall

    2011-01-01

    This paper notes that a high sterilization coefficient plus a de facto pegged exchange rate indicates the existence of dual nominal anchors. The econometric evidence presented shows that several Caribbean economies with fixed exchange rate regimes also possess high sterilization coefficients. Given open capital accounts in the various economies, the paper argues that this finding contravenes the money neutrality thesis, which holds that only one nominal anchor can prevail in the long-term. Th...

  13. Epidermolysis Bullosa Acquisita: Autoimmunity to Anchoring Fibril Collagen

    OpenAIRE

    Chen, Mei; Kim, Gene H; Prakash, Lori; Woodley, David T.

    2011-01-01

    Epidermolysis bullosa acquisita (EBA) is a rare and acquired autoimmune subepidermal bullous disease of the skin and mucosa. EBA includes various distinct clinical manifestations resembling Bullous Pemphigus, Brunsting-Perry pemphigoid, or cicatricial pemphigoid. These patients have autoantibodies against type VII collagen, an integral component of anchoring fibrils, which are responsible for attaching the dermis to the epidermis. Destruction or perturbation of the normally functioning anchor...

  14. Transosseous Acetabular Labral Repair as an Alternative to Anchors

    OpenAIRE

    Pérez-Carro, Luis; Cabello, Andres Gonzalez; Rakha, Mohamed Ibrahim; Patnaik, Sarthak; Centeno, Elias; Miranda, Victor; Fernández, Ana Alfonso

    2015-01-01

    Labral tears are the most common pathology in patients undergoing hip arthroscopy and the most common cause of mechanical hip symptoms. Labral repair techniques have been described in the literature using suture anchors placed as close as possible to the acetabular rim without penetrating the articular surface. Optimal surgical technique for labral repair is very important, and an inappropriate entry point and guide angulation may lead to intra-articular penetration of the anchor, chondral da...

  15. The Effect of Anchoring Sutures on Medicinal Leech Mortality

    OpenAIRE

    Davila, Victor J.; Hoppe, Ian C.; Landi, Rocco; Ciminello, Frank S.

    2009-01-01

    Objective: The implementation of leech therapy for surgical flaps is not always logistically easy or comfortable for patients or healthcare providers. We examine different methods of placing sutures in the medicinal leech, Hirudo medicinalis, to make the implementation of leech therapy easier. Methods: Sixteen leeches were randomly divided into 3 groups: a control group, a deep anchoring suture group, and a superficial anchoring suture group. The leeches were observed to determine if either o...

  16. Anchor stud monotonic and cyclic shear tests. Final report

    International Nuclear Information System (INIS)

    In a prestressed concrete reactor vessel (PCRV), the main cavity liner and other cavity liners with large diameter/thickness (D/t) ratios are anchored to the concrete by anchor studs. These anchor studs are subject to shear loading resulting from prestressing, pressurization, temperature, and creep of the PCRV. The test program discussed in this report consists of both monotonic and cyclic testing of models simulating the prototype anchor stud/concrete assembly. The tests determined the shear stiffness characteristics of the 3/4-in.-diameter, one-piece Nelson anchor stud embedded in concrete and established its low-cycle fatigue life under displacement-controlled loading. The previously obtained results of Phase I and Phase II tests on two-piece anchor studs, along with high-cyclic fatigue data taken from the literature, are discussed and are plotted with the current, Phase III, results to form a displacement versus cycles to failure curve covering a useful range of design applications

  17. Evaluation of mitral valve replacement anchoring in a phantom

    Science.gov (United States)

    McLeod, A. Jonathan; Moore, John; Lang, Pencilla; Bainbridge, Dan; Campbell, Gordon; Jones, Doug L.; Guiraudon, Gerard M.; Peters, Terry M.

    2012-02-01

    Conventional mitral valve replacement requires a median sternotomy and cardio-pulmonary bypass with aortic crossclamping and is associated with significant mortality and morbidity which could be reduced by performing the procedure off-pump. Replacing the mitral valve in the closed, off-pump, beating heart requires extensive development and validation of surgical and imaging techniques. Image guidance systems and surgical access for off-pump mitral valve replacement have been previously developed, allowing the prosthetic valve to be safely introduced into the left atrium and inserted into the mitral annulus. The major remaining challenge is to design a method of securely anchoring the prosthetic valve inside the beating heart. The development of anchoring techniques has been hampered by the expense and difficulty in conducting large animal studies. In this paper, we demonstrate how prosthetic valve anchoring may be evaluated in a dynamic phantom. The phantom provides a consistent testing environment where pressure measurements and Doppler ultrasound can be used to monitor and assess the valve anchoring procedures, detecting pararvalvular leak when valve anchoring is inadequate. Minimally invasive anchoring techniques may be directly compared to the current gold standard of valves sutured under direct vision, providing a useful tool for the validation of new surgical instruments.

  18. Anchor Plates in Two-Layered Cohesion Less Soils

    Directory of Open Access Journals (Sweden)

    Hamed Niroumand

    2010-01-01

    Full Text Available Problem statement: During the past few years a great number of experimental model and numerical analysis results on the uplift resistance of anchor plate embedded in homogeneous cohesion less soil has been reported by many researchers. A review of related literature shows that not much research has been done to analyze the performance of anchor plates in layered soils a problem, which is often encountered by the professional engineers in the field. Approach: This study presented the performance of the anchor plates in the cohesion less soil by different researchers. It was based on different previous researches, from the earliest till the most recent ones. The main aim of this research was focused on the prediction of the anchor plates behavior and the force in the layered cohesion less soils. Few laboratory studies were conducted to investigate the uplift capacity behavior of cohesion less soil by previous researchers. Results: The experimental and numerical investigation included uplift test on cohesion less soil by last researchers. The embedment ratio and the effect of density on uplift response were evaluated. This analysis was investigated experimentally and numerically behavior of anchor plates buried in two layered cohesion less soil. Although earlier researchers developed experimentally expressions to estimate the uplift capacity of irregular anchor plates in layered cohesion less soils. Conclusion: The study observed that the ultimate uplift capacity is dependent on the relative strength of the two layers, the depth ratio of embedment and the upper layer thickness ratio.

  19. Pyramidal anchor stone from Baga waters of Goa, west coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Tripati, S.

    . Pyramidal anchor stones have an apex hole which goes up to the round hole, however Goa anchor stone has no such perforation, but, instead has a rectangular cutting on the apex. The anchor stone is compared with Greek pyramidal anchor stones, and probably...

  20. Transcriptome and biochemical analysis reveals that suppression of GPI-anchor synthesis leads to autophagy and possible necroptosis in Aspergillus fumigatus.

    Directory of Open Access Journals (Sweden)

    Jianghong Yan

    Full Text Available Previously, it has been shown that GPI proteins are required for cell wall synthesis and organization in Aspergillus fumigatus, a human opportunistic pathogen causing life-threatening invasive aspergillosis (IA in immunocompromised patients. Blocking GPI anchor synthesis leads to severe phenotypes such as cell wall defects, increased cell death, and attenuated virulence. However, the mechanism by which these phenotypes are induced is unclear. To gain insight into global effects of GPI anchoring in A. fumigatus, in this study a conditional expression mutant was constructed and a genome wide transcriptome analysis was carried out. Our results suggested that suppression of GPI anchor synthesis mainly led to activation of phosphatidylinositol (PtdIns signaling and ER stress. Biochemical and morphological evidence showed that autophagy was induced in response to suppression of the GPI anchor synthesis, and also an increased necroptosis was observed. Based on our results, we propose that activation of PtdIns3K and increased cytosolic Ca(2+, which was induced by both ER stress and PtdIns signaling, acted as the main effectors to induce autophagy and possible necroptosis.

  1. Living walls for the Vancouver Aquarium

    Energy Technology Data Exchange (ETDEWEB)

    Sharp, R. [Sharp and Diamond Landscape Architecture and Planning, Vancouver, BC (Canada)]|[Verdir Systems Inc., Abbotsford, BC (Canada)

    2005-07-01

    Thermal living walls are developed for exterior locations to provide many of the benefits of green roofs, while also providing greenery in visible locations. Living walls can be used to provide shading, thermal mass, and air filtration for buildings and wildlife habitats. This paper provided details of a set of living walls proposed for the Vancouver Aquarium. The walls were comprised of pockets of growing medium wrapped in moisture retention felt and porous black pumice in an aluminum framework. The pockets were designed to replicate pockets in natural rock faces that support ferns, sedum, columbine and other rainforest plants. The plants were grown from cuttings or plugs anchored in the growing medium. Some plant species were selected to spread by tentacles clinging on to the porous volcanic rock. Soaker hoses will be used to provide moisture weeping down the walls during periods of drought. White roofs will provide cool rainwater which will flow through a series of rainwater gardens and cascade down several terraces. An ecological-based approach was proposed for the Aquarium walls to reduce the requirements for watering, fertilizer and maintenance. The layers and rock pockets have been designed to provide vertical habitats and shelter for a variety of wildlife species. Trellis systems and facade green structures have been designed to connect habitat on green roofs to the ground. It was concluded that the aquarium's living wall will help to educate and inspire the next generation of environmental leaders. A review of innovative living wall and green architecture precedents from around the world included bio-climatic skyscrapers in Malaysia, mur vegetal systems in France, biowalls in Canada; and plant walls in Japan. 8 refs., 19 figs.

  2. A distinct sortase SrtB anchors and processes a streptococcal adhesin AbpA with a novel structural property

    Science.gov (United States)

    Liang, Xiaobo; Liu, Bing; Zhu, Fan; Scannapieco, Frank A.; Haase, Elaine M.; Matthews, Steve; Wu, Hui

    2016-01-01

    Surface display of proteins by sortases in Gram-positive bacteria is crucial for bacterial fitness and virulence. We found a unique gene locus encoding an amylase-binding adhesin AbpA and a sortase B in oral streptococci. AbpA possesses a new distinct C-terminal cell wall sorting signal. We demonstrated that this C-terminal motif is required for anchoring AbpA to cell wall. In vitro and in vivo studies revealed that SrtB has dual functions, anchoring AbpA to the cell wall and processing AbpA into a ladder profile. Solution structure of AbpA determined by NMR reveals a novel structure comprising a small globular α/β domain and an extended coiled-coil heliacal domain. Structural and biochemical studies identified key residues that are crucial for amylase binding. Taken together, our studies document a unique sortase/adhesion substrate system in streptococci adapted to the oral environment rich in salivary amylase. PMID:27492581

  3. A distinct sortase SrtB anchors and processes a streptococcal adhesin AbpA with a novel structural property.

    Science.gov (United States)

    Liang, Xiaobo; Liu, Bing; Zhu, Fan; Scannapieco, Frank A; Haase, Elaine M; Matthews, Steve; Wu, Hui

    2016-01-01

    Surface display of proteins by sortases in Gram-positive bacteria is crucial for bacterial fitness and virulence. We found a unique gene locus encoding an amylase-binding adhesin AbpA and a sortase B in oral streptococci. AbpA possesses a new distinct C-terminal cell wall sorting signal. We demonstrated that this C-terminal motif is required for anchoring AbpA to cell wall. In vitro and in vivo studies revealed that SrtB has dual functions, anchoring AbpA to the cell wall and processing AbpA into a ladder profile. Solution structure of AbpA determined by NMR reveals a novel structure comprising a small globular α/β domain and an extended coiled-coil heliacal domain. Structural and biochemical studies identified key residues that are crucial for amylase binding. Taken together, our studies document a unique sortase/adhesion substrate system in streptococci adapted to the oral environment rich in salivary amylase. PMID:27492581

  4. Perceptual anchoring in preschool children: not adultlike, but there.

    Directory of Open Access Journals (Sweden)

    Karen Banai

    Full Text Available BACKGROUND: Recent studies suggest that human auditory perception follows a prolonged developmental trajectory, sometimes continuing well into adolescence. Whereas both sensory and cognitive accounts have been proposed, the development of the ability to base current perceptual decisions on prior information, an ability that strongly benefits adult perception, has not been directly explored. Here we ask whether the auditory frequency discrimination of preschool children also improves when given the opportunity to use previously presented standard stimuli as perceptual anchors, and whether the magnitude of this anchoring effect undergoes developmental changes. METHODOLOGY/PRINCIPAL FINDINGS: Frequency discrimination was tested using two adaptive same/different protocols. In one protocol (with-reference, a repeated 1-kHz standard tone was presented repeatedly across trials. In the other (no-reference, no such repetitions occurred. Verbal memory and early reading skills were also evaluated to determine if the pattern of correlations between frequency discrimination, memory and literacy is similar to that previously reported in older children and adults. Preschool children were significantly more sensitive in the with-reference than in the no-reference condition, but the magnitude of this anchoring effect was smaller than that observed in adults. The pattern of correlations among discrimination thresholds, memory and literacy replicated previous reports in older children. CONCLUSIONS/SIGNIFICANCE: The processes allowing the use of context to form perceptual anchors are already functional among preschool children, albeit to a lesser extent than in adults. Nevertheless, immature anchoring cannot fully account for the poorer frequency discrimination abilities of young children. That anchoring is present among the majority of typically developing preschool children suggests that the anchoring deficits observed among individuals with dyslexia represent a

  5. Design of SC walls and slabs for impulsive loading

    Energy Technology Data Exchange (ETDEWEB)

    Varma, Amit H. [Purdue Univ., West Lafayette, IN (United States)

    2015-11-11

    Reinforced concrete (RC) structures have historically been the preferred choice for blast resistant structures because of their mass and the ductility provided by steel reinforcement. Steel-plate composite (SC) walls are a viable alternative to RC for protecting the infrastructure against explosive threats. SC structures consist of two steel faceplates with a plain concrete core between them. The steel faceplates are anchored to the concrete using stud anchors and connected to each other using tie bars. SC structures provide mass from the concrete infill and ductility from the continuous external steel faceplates. This dissertation presents findings and recommendations from experimental and analytical investigations of the performance of SC walls subjected to far-field blast loads.

  6. Use of radiotracer for the characterization of anchor-type discontinued reactors

    International Nuclear Information System (INIS)

    The infusion rate of a slug of tracer into an anchor agitated 100 liters batch mixer was characterised by a decay rate constant. This constant was then used to define a dimensionless mixing-rate number which was related to achieve any desired degree of uniformity of the mixture. Tc 99m was used as radiotracer and the mixing process was followed by two scintillation NaI(Ti) sondes situated on the reactor wall at 46 cm from its bottom, one of them near the injection point and the other one in the opposite side. The experimental data was processed by means of a specially for these calculations elaborated program. The programming language was Visual Basic-version 3.0 and Access-version 2.0 was used for data bases making

  7. Optical Fiber Grating Sensor for Force Measurement of Anchor Cable

    Institute of Scientific and Technical Information of China (English)

    JIANG Desheng; FU Jinghua; LIU Shengchun; SUI Lingfeng; FU Rong

    2006-01-01

    The development of the sensor suitable for measuring large load stress to the anchor cable becomes an important task in bridge construction and maintenance. Therefore, a new type of optical fiber sensor was developed in the laboratory - optical fiber grating sensor for force measurement of anchor cable (OFBFMAC). No similar report about this kind of sensor has been found up to now in China and other countries. This sensor is proved to be an effective way of monitoring in processes of anchor cable installation, cable cutting, cable force regulation, etc, with the accurate and repeatable measuring results. Its successful application in the tie bar cable force safety monitoring for Wuhan Qingchuan bridge is a new exploration of optical fiber grating sensing technology in bridge tie bar monitoring system.

  8. Plate anchored stirrup; Pureto teichakugata sendan hokyo tekkin

    Energy Technology Data Exchange (ETDEWEB)

    Nakamura, T.; Tanaka, Y.; Nakano, K.; Yamamoto, T. [Taisei Construction Co. Ltd., Tokyo (Japan)

    1998-09-01

    After the Great Hanshin Earthquake, the use of edge form of stirrups of semicircular hook or acute-angled hook which functions sufficiently even after exfoliation of concrete cover is proposed instead of right angle hook. However, when these stirrups are used in plate structures requiring hooks on two ends or in columns as connection reinforcement of hoop, the construction of these stirrups is so complicated that brings higher cost. The authors proposes stirrups to anchor by plate for stirrups of planar members. Anchorage capacity of these plate anchored stirrups and hooks after exfoliation of concrete cover was examined by experiments and the anchorage capacity was confirmed to be larger than that of semicircular hooks. The plate anchored stirrups are effective and easy to construct with low cost. 7 refs., 13 figs., 4 tabs.

  9. Locomotion in a liquid crystal near a wall

    Science.gov (United States)

    Powers, Thomas; Krieger, Madison; Spagnolie, Saverio

    2015-11-01

    Recent observations of bacteria swimming in nematic liquid crystal solution motivate the theoretical study of how swimming speed depends on liquid crystal properties. We consider the Taylor sheet near a wall, in which propulsion is achieved by the propagation of traveling waves along the length of the swimmer. Using the lubrication approximation, we determine how swimming speed depends on the Ericksen number, which is the ratio of elastic to viscous stresses. We also study the effect of anchoring strength, at the surface of the swimmer and the surface of the wall. Supported by NSF-CBET 1437195.

  10. Falling walls

    CERN Multimedia

    It was 20 years ago this week that the Berlin wall was opened for the first time since its construction began in 1961. Although the signs of a thaw had been in the air for some time, few predicted the speed of the change that would ensue. As members of the scientific community, we can take a moment to reflect on the role our field played in bringing East and West together. CERN’s collaboration with the East, primarily through links with the Joint Institute for Nuclear Research, JINR, in Dubna, Russia, is well documented. Less well known, however, is the role CERN played in bringing the scientists of East and West Germany together. As the Iron curtain was going up, particle physicists on both sides were already creating the conditions that would allow it to be torn down. Cold war historian Thomas Stange tells the story in his 2002 CERN Courier article. It was my privilege to be in Berlin on Monday, the anniversary of the wall’s opening, to take part in a conference entitled &lsquo...

  11. Unimpeded permeation of water through biocidal graphene oxide sheets anchored on to 3D porous polyolefinic membranes

    Science.gov (United States)

    Mural, Prasanna Kumar S.; Jain, Shubham; Kumar, Sachin; Madras, Giridhar; Bose, Suryasarathi

    2016-04-01

    3D porous membranes were developed by etching one of the phases (here PEO, polyethylene oxide) from melt-mixed PE/PEO binary blends. Herein, we have systematically discussed the development of these membranes using X-ray micro-computed tomography. The 3D tomograms of the extruded strands and hot-pressed samples revealed a clear picture as to how the morphology develops and coarsens over a function of time during post-processing operations like compression molding. The coarsening of PE/PEO blends was traced using X-ray micro-computed tomography and scanning electron microscopy (SEM) of annealed blends at different times. It is now understood from X-ray micro-computed tomography that by the addition of a compatibilizer (here lightly maleated PE), a stable morphology can be visualized in 3D. In order to anchor biocidal graphene oxide sheets onto these 3D porous membranes, the PE membranes were chemically modified with acid/ethylene diamine treatment to anchor the GO sheets which were further confirmed by Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS) and surface Raman mapping. The transport properties through the membrane clearly reveal unimpeded permeation of water which suggests that anchoring GO on to the membranes does not clog the pores. Antibacterial studies through the direct contact of bacteria with GO anchored PE membranes resulted in 99% of bacterial inactivation. The possible bacterial inactivation through physical disruption of the bacterial cell wall and/or reactive oxygen species (ROS) is discussed herein. Thus this study opens new avenues in designing polyolefin based antibacterial 3D porous membranes for water purification.3D porous membranes were developed by etching one of the phases (here PEO, polyethylene oxide) from melt-mixed PE/PEO binary blends. Herein, we have systematically discussed the development of these membranes using X-ray micro-computed tomography. The 3D tomograms of the extruded strands and

  12. Proteomic analysis of GPI-anchored membrane proteins

    DEFF Research Database (Denmark)

    Jung, Hye Ryung; Jensen, Ole Nørregaard

    2006-01-01

    humans. GPI-APs confer important cellular functions as receptors, enzymes and scaffolding molecules. Specific enzymes and detergent extraction methods combined with separation technologies and mass spectrometry permit proteomic analysis of GPI-APs from plasma membrane preparations to reveal cell......Glycosyl-phosphatidyl-inositol-anchored proteins (GPI-APs) represent a subset of post-translationally modified proteins that are tethered to the outer leaflet of the plasma membrane via a C-terminal GPI anchor. GPI-APs are found in a variety of eukaryote species, from pathogenic microorganisms to...

  13. Addition of lipid substituents of mammalian protein glycosylphosphoinositol anchors.

    OpenAIRE

    Singh, N.; Zoeller, R A; Tykocinski, M. L.; Lazarow, P B; Tartakoff, A M

    1994-01-01

    A single metabolic path leading to synthesis of ether lipids is known in animal cells, the major products of which are plasmalogens. To learn whether this peroxisomal path is also responsible for the synthesis of base-resistant lipid components of glycosylphosphoinositol (GPI)-anchored membrane proteins, we have investigated the structure of anchor precursor mannolipids both in wild-type cells (CHO-K1 and a macrophage-like line, RAW 264.7) and in two corresponding mutant cells in which ether ...

  14. PULLOUT CAPACITY OF HORIZONTAL AND INCLINED PLATE ANCHORS IN CLAYEY SOILS

    Directory of Open Access Journals (Sweden)

    BALESHWAR SINGH

    2011-11-01

    Full Text Available Soil anchors are required to withstand uplift or lateral forces acting on the foundations of structures constructed both in land and offshore sites. Plate anchoring system is being increasingly used to moor floating structures for the exploration and development of oil and gas fields. In this study, various experimental,theoretical and numerical approaches for estimation of pullout capacity of horizontal and inclined plate anchors in clayey soils are reviewed. A comparative analysis of the ultimate capacity is then carried out for plate anchors embedded in clayey soils by varying embedment ratio for horizontal anchors and by varying inclination angle for inclined plate anchors.

  15. Current status of frameless anchored IUD for immediate intracesarean insertion.

    Science.gov (United States)

    Wildemeersch, Dirk; Goldstuck, Norman D; Hasskamp, Thomas

    2016-01-01

    Immediate postpartum intrauterine device (IUD) insertion deserves great attention as it can provide immediate, timely and convenient contraception plus the added benefit of preventing repeat unintended pregnancies. Although women post vaginal delivery can benefit from immediate post-placenta contraception, women undergoing Cesarean section clearly need contraception, as an inter-delivery interval shorter than 18 months places them at a high risk for uterine rupture. The main drawback of currently available framed IUD devices for immediate postpartum insertion of an IUD is their high expulsion and displacement rates when inserted immediately postpartum after both vaginal and Cesarean delivery. Current research suggests that a brief window of opportunity exists of 10 minutes for insertion of conventional IUDs after which time expulsion rates both immediately and over time are greatly enhanced. This paper summarizes the current research conducted to overcome the expulsion problems associated with conventional T-shaped devices as well as through the use of an anchored frameless device. In the 1970s and 1980s, attempts were made to solve the expulsion problem by modifying existing devices, such as adding absorbable sutures (Delta-T) or additional appendages. These attempts proved to be clinically unsuccessful as the catgut suture added to the transverse arms did not provide sufficient resistance to prevent downward displacement and expulsion. An anchoring technique to suspend a copper IUD to the fundus of the uterus was developed in Belgium in the 1980s and has been the subject of extensive ongoing clinical research since 1985. Recently the frameless copper releasing anchor IUD, GyneFix, has been tested for postplacental insertion. Initially, the anchor was modified by the inclusion of a biodegradable cone which was added below the anchoring knot. Clinical studies confirmed the adequacy of this approach suggesting that it was technically possible to anchor an IUD

  16. [Dactylogyrids (Monogenea: Dactylogyridea) with an unusual number of anchors, their origin and phylogenetic significance. Reference data].

    Science.gov (United States)

    Gerasev, P I

    2002-01-01

    It is considered that in Anacanthorinae, Markewitschiana and Pseudacolpenteron pavlovskii (Dactylogyridae s. s.) the anchors are absent originally. In the other dactylogyrids (s. l.) without anchors (Pseudacolpenteron ignotus; Acolpenteron; Anonchohaptor-Icelanchohaptor; Kritskyia-Telethecium-Pavanelliela) these structures are lost. In related genera Rhinoxenus and Nanotrema the dorsal pair of anchors is transformed into the "spikes"; in Heteronchocleidinae there is one anchor; in Trinigyrus and Schilbetrematoides are two anchors; and in Urogyrus three anchors are reduced. But in Rhinonaster, Cacatyocotyle, Callceostomella, Neocalseostoma elongatum and Pseudodactylogyridae the presence of one pair of ventral "peduncular" or "haptoral" anchors appear to be the original state. For Anacanthorinae and Dactylogyridae s. s. the presence of 18-16 hooks, original lacking of anchors, appearance of one pair of them, evolutionary development and subsequent reduction of these structures are characteristic. In the dactylogyrids (s. l.) having two pairs of anchors and 14 hooks, one pair of the anchors is present originally, then usually the second dorsal pair grows up, and finally, the reduction of a part of anchors or all the anchors is possible. In the 16-hooked dactylogyrids (s. l.) having two pairs of anchors (Tetraonchinea, Amphibdellainea, Neodactylodiscinea) the original lacking or reduction of the anchors is not reported. The author considers, that it is unwarranted to unite all dactylogyrids (s. l.) without anchors into the superorder Ananchorea Malmberg, 1990 or to postulate the original presence of the two pairs of ventral anchors in this group. It is also impossible to unit all dactylogyrids (s. l.) having 0-4 anchors and 18-14 hooks into Dactylogyridae sensu Boeger et Kritsky, 1993. PMID:12070963

  17. SNP Discovery and Chromosome Anchoring Provide the First Physically-Anchored Hexaploid Oat Map and Reveal Synteny with Model Species.

    OpenAIRE

    Rebekah E Oliver; Tinker, Nicholas A.; Lazo, Gerard R.; Shiaoman Chao; Jellen, Eric N.; Martin L. Carson; Rines, Howard W; Donald E Obert; Lutz, Joseph D.; Irene Shackelford; Korol, Abraham B.; Charlene P. Wight; Gardner, Kyle M.; Jiro Hattori; Beattie, Aaron D

    2013-01-01

    A physically anchored consensus map is foundational to modern genomics research; however, construction of such a map in oat (Avena sativa L., 2n = 6x = 42) has been hindered by the size and complexity of the genome, the scarcity of robust molecular markers, and the lack of aneuploid stocks. Resources developed in this study include a modified SNP discovery method for complex genomes, a diverse set of oat SNP markers, and a novel chromosome-deficient SNP anchoring strategy. These resources wer...

  18. 76 FR 10627 - Assumption Buster Workshop: Trust Anchors Are Invulnerable

    Science.gov (United States)

    2011-02-25

    ...) Committee, an interagency working group that coordinates cyber security research activities in support of... confident that they are immune from the attacks.'' This assertion underlies significant cyber security research and development that is aimed at developing and implementing invulnerable trust anchors,...

  19. Localization in Wireless Sensor Networks and Anchor Placement

    Directory of Open Access Journals (Sweden)

    Benjamin Tatham

    2012-06-01

    Full Text Available Applications of wireless sensor network (WSN often expect knowledge of the precise location of the nodes. Many different localization protocols have been proposed that allow nodes to derive their location rather than equipping them with dedicated localization hardware such as GPS receivers, which increases node costs. We provide a brief survey of the major approaches to software-based node localization in WSN. One class of localization protocols with good localization performance patches together relative-coordinate, local maps into a global-coordinate map. These protocols require some nodes that know their absolute coordinates, called anchor nodes. While many factors influence the node position errors, in this class of protocols, using Procrustes Analysis, the placement of the anchor nodes can significantly impact the error. Through simulation, using the Curvilinear Component Analysis (CCA-MAP protocol as a representative protocol in this category, we show the impact of anchor node placement and propose a set of guidelines to ensure the best possible outcome, while using the smallest number of anchor nodes possible.

  20. When Does Scale Anchoring Work? A Case Study

    Science.gov (United States)

    Sinharay, Sandip; Haberman, Shelby J.; Lee, Yi-Hsuan

    2011-01-01

    Providing information to test takers and test score users about the abilities of test takers at different score levels has been a persistent problem in educational and psychological measurement. Scale anchoring, a technique which describes what students at different points on a score scale know and can do, is a tool to provide such information.…

  1. The importance of anchor text for ad hoc search revisited

    NARCIS (Netherlands)

    M. Koolen; J. Kamps

    2010-01-01

    It is generally believed that propagated anchor text is very important for effective Web search as offered by the commercial search engines. "Google Bombs" are a notable illustration of this. However, many years of TREC Web retrieval research failed to establish the effectiveness of link evidence fo

  2. Ten Anchor Points for Teaching Principles of Marketing

    Science.gov (United States)

    Tomkovick, Chuck

    2004-01-01

    Effective marketing instructors commonly share a love for their students, an affinity for the subject matter, and a devotion to continuous quality improvement. The purpose of this article is to highlight 10 anchor points for teaching Principles of Marketing, which are designed to better engage students in the learning process. These anchor…

  3. A+: Adjusted anchored neighborhood regression for fast super-resolution

    OpenAIRE

    Timofte, Radu; De Smet, Vincent; Van Gool, Luc

    2015-01-01

    Timofte R., De Smet V., Van Gool L., ''A+: Adjusted anchored neighborhood regression for fast super-resolution'', Lecture notes in computer science, vol. 9006, part IV, pp. 111-126, 2015 (12th Asian conference on computer vision - ACCV 2014, November 1-5, 2014, Singapore).

  4. Analytical Model for Hook Anchor Pull-Out

    DEFF Research Database (Denmark)

    Brincker, Rune; Ulfkjær, J. P.; Adamsen, P.;

    1995-01-01

    A simple analytical model for the pull-out of a hook anchor is presented. The model is based on a simplified version of the fictitious crack model. It is assume that the fracture process is the pull-off of a cone shaped concrete part, simplifying the problem by assuming pure rigid body motions...

  5. Analytical Model for Hook Anchor Pull-out

    DEFF Research Database (Denmark)

    Brincker, Rune; Ulfkjær, J. P.; Adamsen, P.;

    A simple analytical model for the pull-out of a hook anchor is presented. The model is based on a simplified version of the fictitious crack model. It is assumed that the fracture process is the pull-off of a cone shaped concrete part, simplifying the problem by assuming pure rigid body motions...

  6. Impact of Enhanced Anchored Instruction in Inclusive Math Classrooms

    Science.gov (United States)

    Bottge, Brian A.; Toland, Michael D.; Gassaway, Linda; Butler, Mark; Choo, Sam; Griffen, Ann Katherine; Ma, Xin

    2015-01-01

    The Common Core State Standards for Mathematics will place more pressure on special education and math teachers to raise the skill levels of all students, especially those with disabilities in math (MD). The purpose of this study was to assess the effects of enhanced anchored instruction (EAI) on students with and without MD in co-taught general…

  7. Experience-based, body-anchored qualitative research interviewing

    DEFF Research Database (Denmark)

    Stelter, Reinhard

    2010-01-01

    -anchored interviewing, and second, by an interview guide that explores a research participant's personal experience with mindfulness meditation. An excerpt from an interview is discussed to illustrate the advantages of this interview form, namely its value as a methodological instrument for qualitative research in...

  8. Fullerene-based Anchoring Groups for Molecular Electronics

    DEFF Research Database (Denmark)

    Martin, Christian A.; Ding, Dapeng; Sørensen, Jakob Kryger;

    2008-01-01

    We present results on a new fullerene-based anchoring group for molecular electronics. Using lithographic mechanically controllable break junctions in vacuum we have determined the conductance and stability of single-molecule junctions of 1,4-bis(fullero[c]pyrrolidin-1-yl)benzene. The compound can...

  9. Preliminary X-ray characterization of a novel type of anchoring cohesin from the cellulosome of Ruminococcus flavefaciens

    International Nuclear Information System (INIS)

    The cloning, expression, purification, crystallization and preliminary X-ray characterization of a novel class of cohesin module (type III) from the R. flavefaciens ScaE anchoring scaffoldin are described. Ruminococcus flavefaciens is an anaerobic bacterium that resides in the gastrointestinal tract of ruminants. It produces a highly organized multi-enzyme cellulosome complex that plays a key role in the degradation of plant cell walls. ScaE is one of the critical structural components of its cellulosome that serves to anchor the complex to the cell wall. The seleno-l-methionine-labelled derivative of the ScaE cohesin module has been cloned, expressed, purified and crystallized. The crystals belong to space group C2, with unit-cell parameters a = 155.6, b = 69.3, c = 93.0 Å, β = 123.4°, and contain four molecules in the asymmetric unit. Diffraction data were phased to 1.95 Å using the anomalous signal from the Se atoms

  10. A Single-hole stone anchor from Kottapatnam: Early historic port site of Andhra Pradesh, India

    Digital Repository Service at National Institute of Oceanography (India)

    Tripati, S.; Rao, K.P.; Kumari, S.; Imsong, O.; Vanlalhruaitluangi, V.

    broken piece of polished stone celt in addition to other findings. The recent explorations brought to light a Vijayanagar period coin, pottery and a single hole stone anchor. The finding of the stone anchor throws light on the maritime activities...

  11. Anchoring a Leviathan: How the Nuclear Membrane Tethers the Genome

    Directory of Open Access Journals (Sweden)

    Rafal eCzapiewski

    2016-05-01

    Full Text Available It is well established that the nuclear envelope has many distinct direct connections to chromatin that contribute to genome organization. The functional consequences of genome organization on gene regulation are less clear. Even less understood is how interactions of lamins and nuclear envelope transmembrane proteins (NETs with chromatin can produce anchoring tethers that can withstand the physical forces of and on the genome. Chromosomes are the largest molecules in the cell, making megadalton protein structures like the nuclear pore complexes and ribosomes seem small by comparison. Thus to withstand strong forces from chromosome dynamics an anchoring tether is likely to be much more complex than a single protein-protein or protein-DNA interaction. Here we will briefly review known NE-genome interactions that likely contribute to spatial genome organization, postulate in the context of experimental data how these anchoring tethers contribute to gene regulation, and posit several hypotheses for the physical nature of these tethers that need to be investigated experimentally. Significantly, disruption of these anchoring tethers and the subsequent consequences for gene regulation could explain how mutations in nuclear envelope proteins cause diseases ranging from muscular dystrophy to lipodystrophy to premature ageing progeroid syndromes. The two favored hypotheses for nuclear envelope protein involvement in disease are 1 weakening nuclear and cellular mechanical stability, and 2 disrupting genome organization and gene regulation. Considerable experimental support has been obtained for both. The integration of both mechanical and gene expression defects in the disruption of anchoring tethers could provide a unifying hypothesis consistent with both.

  12. Characterizing the flow of stirred vessels with anchor type impellers

    Directory of Open Access Journals (Sweden)

    Peixoto S.M.C.

    2000-01-01

    Full Text Available Despite its importance in chemical industries, there are few works which studies anchor type impellers and only a fraction of the works investigate these systems under a computational approach. The great majority refers to turbine impellers, specially Rushton turbines, under turbulent flow. Anchor impellers are used specially for highly viscous flow, typical of polymer reactions. The viscosity is normally in the range 1000-10000 cp. Since this range of viscosity describe highly viscous flows, the reactions for anchor agitated systems are normally carried out under laminar flow. This work presents a detailed computational fluid dynamics (CFD approach to study the behaviour of stirred vessels using anchor impellers. The axial plane of the tank, which is being modelled, is divided into small control volumes, which collectively is referred to as the mesh, or grid. In each of these cells the momentum balance, energy and mass conservation, which describes the model, are rewritten algebraically using the finite volumes method to relate such variables as velocity, pressure and temperature to values in neighbouring cells. The equations are then solved numerically, and the results yield the flow corresponding to the model. Since the geometry of a vessel with anchor impellers strictly calls for a three dimensional method, an approximation is made to account for the effect of the blades (Kuncewics, 1992. The main objective of this work is to give a detailed description of the flow generated by this axial impeller with a view to indicate ways in which the design and operation of these systems can be improved.

  13. An Investigation to Determine the Career Anchors Which Affect the Career Decision of Tourism Students

    OpenAIRE

    GEZEN, Tuba; Köroğlu, Özlem

    2014-01-01

    AbstractAlthough career anchors are used as a career tool in organizations, are examined in many limited researches. The purpose of this study is to determine the career anchors which affect the job and career decision of the tourism students. Therefore, Tourism and Hotel Management students who attend four-year programs/departments of Balikesir University have been conducted surveys. The Career Anchors Scale developed by Schein (1990) has been used to determine the career anchors of the tour...

  14. Developments, expectations of wave energy converters and mooring anchors in the UK

    Science.gov (United States)

    Huang, Ming; Aggidis, G. A.

    2008-02-01

    The paper introduces the important developments of Wave Energy Converters (WECs) in the UK, and the generic anchor types for WECs and similar structures. Several WECs and their characteristics are introduced to explain the development direction. The anchors are discussed in relation to the behaviour and performance of WECs, and comparisons are made with similar aspects of the offshore industry. Typical and desirable features of anchors for WECs are summarized. Additionally, expectations and research suggestions for WECs and their anchor design are presented.

  15. Cement grouting during installation of ground anchors in non-cohesive soils

    OpenAIRE

    Domes, Xenia A. L.

    2015-01-01

    Pressure grouting during installation of grouted ground anchors is known to increase anchor capacity in non-cohesive soils, but little information is available on correlations between applied grouting pressures, duration of grouting, ground conditions and increase of anchor pull-out capacity. The presented PhD study is concerned with processes taking place during installation of grouted ground anchors in non-cohesive soils, where filtration of the cement grout is assumed. It...

  16. Competition of elastic and adhesive properties of carbon nanotubes anchored to atomic force microscopy tips

    International Nuclear Information System (INIS)

    In this paper we address the mechanical properties of carbon nanotubes anchored to atomic force microscopy (AFM) tips in a detailed analysis of experimental results and exhaustive description of a simple model. We show that volume elastic and surface adhesive forces both contribute to the dynamical AFM experimental signals. Their respective weights depend on the nanotube properties and on an experimental parameter: the oscillation amplitude. To quantify the elastic and adhesive contributions, a simple analytical model is used. It enables analytical expressions of the resonance frequency shift and dissipation that can be measured in the atomic force microscopy dynamical frequency modulation mode. It includes the nanotube adhesive contribution to the frequency shift. Experimental data for single-wall and multi-wall carbon nanotubes compare well to the model predictions for different oscillation amplitudes. Three parameters can be extracted: the distance necessary to unstick the nanotube from the surface and two spring constants corresponding to tube compression and to the elastic force required to overcome the adhesion force

  17. A group of 20 stone anchors from the waters of Dwarka, on the Gujarat Coast, India

    Digital Repository Service at National Institute of Oceanography (India)

    Gaur, A; Sundaresh; Tripati, S.; Gudigar, P.; Vora, K.H.; Bandodkar, S.N.

    A large number of stone anchors were discovered in a water depth of 10-14 m off Dwarka during the 1998-99 season. The seabed near the anchors consists of a ledge with an average height of 1 m. Several anchors were found trapped between the rocks...

  18. 33 CFR 401.83 - Reporting position at anchor, wharf, etc.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Reporting position at anchor, wharf, etc. 401.83 Section 401.83 Navigation and Navigable Waters SAINT LAWRENCE SEAWAY DEVELOPMENT... § 401.83 Reporting position at anchor, wharf, etc. A vessel anchoring in a designated anchorage area,...

  19. Biomimetic Mussel Adhesive Inspired Clickable Anchors Applied to the Functionalization of Fe3O4 Nanoparticles

    NARCIS (Netherlands)

    Goldmann, Anja S.; Schoedel, Christine; Walther, Andreas; Yuan, Jiayin; Loos, Katja; Mueller, Axel H. E.; Müller, Axel H.E.

    2010-01-01

    The functionalization of magnetite (Fe3O4) nanoparticles with dopamine-derived clickable biomimetic anchors is reported. Herein, an alkyne-modified catechol-derivative is employed as the anchor, as i) the catechol-functional anchor groups possess irreversible covalent binding affinity to Fe3O4 nanop

  20. Displaying Lipase B from Candida antarctica in Pichia pastoris Using the Yeast Surface Display Approach: Prospection of a New Anchor and Characterization of the Whole Cell Biocatalyst.

    Directory of Open Access Journals (Sweden)

    Marcelo Victor Holanda Moura

    Full Text Available Yeast Surface Display (YSD is a strategy to anchor proteins on the yeast cell wall which has been employed to increase enzyme stability thus decreasing production costs. Lipase B from Candida antarctica (LipB is one of the most studied enzymes in the context of industrial biotechnology. This study aimed to assess the biochemical features of this important biocatalyst when immobilized on the cell surface of the methylotrophic yeast Pichia pastoris using the YSD approach. For that purpose, two anchors were tested. The first (Flo9 was identified after a prospection of the P. pastoris genome being related to the family of flocculins similar to Flo1 but significantly smaller. The second is the Protein with Internal Repeats (Pir1 from P. pastoris. An immunolocalization assay showed that both anchor proteins were able to display the reporter protein EGFP in the yeast outer cell wall. LipB was expressed in P. pastoris fused either to Flo9 (FLOLIPB or Pir1 (PIRLIPB. Both constructions showed hydrolytic activity towards tributyrin (>100 U/mgdcw and >80 U/mgdcw, respectively, optimal hydrolytic activity around 45°C and pH 7.0, higher thermostability at 45°C and stability in organic solvents when compared to a free lipase.

  1. Displaying Lipase B from Candida antarctica in Pichia pastoris Using the Yeast Surface Display Approach: Prospection of a New Anchor and Characterization of the Whole Cell Biocatalyst

    Science.gov (United States)

    Moura, Marcelo Victor Holanda; da Silva, Giulia Pontes; Machado, Antônio Carlos de Oliveira; Torres, Fernando Araripe Gonçalves; Freire, Denise Maria Guimarães; Almeida, Rodrigo Volcan

    2015-01-01

    Yeast Surface Display (YSD) is a strategy to anchor proteins on the yeast cell wall which has been employed to increase enzyme stability thus decreasing production costs. Lipase B from Candida antarctica (LipB) is one of the most studied enzymes in the context of industrial biotechnology. This study aimed to assess the biochemical features of this important biocatalyst when immobilized on the cell surface of the methylotrophic yeast Pichia pastoris using the YSD approach. For that purpose, two anchors were tested. The first (Flo9) was identified after a prospection of the P. pastoris genome being related to the family of flocculins similar to Flo1 but significantly smaller. The second is the Protein with Internal Repeats (Pir1) from P. pastoris. An immunolocalization assay showed that both anchor proteins were able to display the reporter protein EGFP in the yeast outer cell wall. LipB was expressed in P. pastoris fused either to Flo9 (FLOLIPB) or Pir1 (PIRLIPB). Both constructions showed hydrolytic activity towards tributyrin (>100 U/mgdcw and >80 U/mgdcw, respectively), optimal hydrolytic activity around 45°C and pH 7.0, higher thermostability at 45°C and stability in organic solvents when compared to a free lipase. PMID:26510006

  2. Iron anchors of Northern Odisha, east coast India: Maritime contacts with European countries

    Digital Repository Service at National Institute of Oceanography (India)

    Tripati, S.; Patnaik, S.K.; Acharya, S.B.

    at Siraf. Second Interim Report. Iran 8: 1–17. 12    List of Figures Figure 1. Iron anchor find sites, ports and trade centres of Odisha. Figure 2. Iron anchor found at Balaramgadi, Northern Odisha (Photo: Sila Tripati) Figure 2a. Iron anchor found... at Balaramgadi, Northern Odisha (S.B. Chitari & Rudra Behera). Figure 3. Iron anchor found at Chandabali on the mouth of the River Baitarani (OMISEAS, Bhubaneswar). Figure 4. Iron anchor found at Chandabali on the mouth of the River Baitarani (Photo: Sila...

  3. Mobile Anchor Assisted Node Localization for Wireless Sensor Networks

    CERN Document Server

    Chen, Hongyang; Huang, Pei; Poor, H Vincent; Sezaki, Kaoru

    2009-01-01

    In this paper, a cooperative localization algorithm is proposed that considers the existence of obstacles in mobilityassisted wireless sensor networks (WSNs). In this scheme, a mobile anchor (MA) node cooperates with static sensor nodes and moves actively to refine location performance. The localization accuracy of the proposed algorithm can be improved further by changing the transmission range of mobile anchor node. The algorithm takes advantage of cooperation betweenMAs and static sensors while, at the same time, taking into account the relay node availability to make the best use of beacon signals. For achieving high localization accuracy and coverage, a novel convex position estimation algorithm is proposed, which can effectively solve the localization problem when infeasible points occur because of the effects of radio irregularity and obstacles. This method is the only range-free based convex method to solve the localization problem when the feasible set of localization inequalities is empty. Simulatio...

  4. Proteomic analysis of glycosylphosphatidylinositol-anchored membrane proteins

    DEFF Research Database (Denmark)

    Elortza, Felix; Nühse, Thomas S; Foster, Leonard J;

    2003-01-01

    Glycosylphosphatidylinositol-anchored proteins (GPI-APs) are a functionally and structurally diverse family of post-translationally modified membrane proteins found mostly in the outer leaflet of the plasma membrane in a variety of eukaryotic cells. Although the general role of GPI-APs remains...... unclear, they have attracted attention because they act as enzymes and receptors in cell adhesion, differentiation, and host-pathogen interactions. GPI-APs may represent potential diagnostic and therapeutic targets in humans and are interesting in plant biotechnology because of their key role in root...... and 44 GPI-APs in an Arabidopsis thaliana membrane preparation, representing the largest experimental dataset of GPI-anchored proteins to date....

  5. Graphene nanoribbons anchored to SiC substrates

    Science.gov (United States)

    Le, Nam B.; Woods, Lilia M.

    2016-09-01

    Graphene nanoribbons are quasi-one-dimensional planar graphene allotropes with diverse properties dependent on their width and types of edges. Graphene nanoribbons anchored to substrates is a hybrid system, which offers novel opportunities for property modifications as well as experimental control. Here we present electronic structure calculations of zigzag graphene nanoribbons chemically attached via the edges to the Si or C terminated surfaces of a SiC substrate. The results show that the edge characteristics are rather robust and the properties are essentially determined by the individual nanoribbon. While the localized spin polarization of the graphene nanoribbon edge atoms is not significantly affected by the substrate, secondary energy gaps in the highest conduction and lowest valence region may emerge in the anchored structures. The van der Waals interaction together with the electrostatic interactions due to the polarity of the surface bonds are found to be important for the structure parameters and energy stability.

  6. Anchoring FRP Composite Armor in Flexible Offshore Riser Systems

    DEFF Research Database (Denmark)

    Costache, Andrei

    Unbonded flexible pipes find extensive use in the offshore oil industry. Although more expensive than rigid pipe, the total cost of flexible pipe installations are often less. This is because flexible pipes are easier to store and deploy, coupled with superior fatigue performance. Among other...... composite materials. One of the problems related to the substitution of tensile steel members is that anchoring in the metallic end fittings of the pipe is very challenging.The purpose of this thesis is to ensure the transfer of tensile loads between a unidirectional fiber reinforced polymer and a metallic...... the grip, and to measure the contact stresses distribution and evolution during pullout.The results of the experimental and numerical analysis show that it is possible to reliably anchor composite materials using a metallic grip. The models developed during the project show how to improve the...

  7. Graphene nanoribbons anchored to SiC substrates.

    Science.gov (United States)

    Le, Nam B; Woods, Lilia M

    2016-09-14

    Graphene nanoribbons are quasi-one-dimensional planar graphene allotropes with diverse properties dependent on their width and types of edges. Graphene nanoribbons anchored to substrates is a hybrid system, which offers novel opportunities for property modifications as well as experimental control. Here we present electronic structure calculations of zigzag graphene nanoribbons chemically attached via the edges to the Si or C terminated surfaces of a SiC substrate. The results show that the edge characteristics are rather robust and the properties are essentially determined by the individual nanoribbon. While the localized spin polarization of the graphene nanoribbon edge atoms is not significantly affected by the substrate, secondary energy gaps in the highest conduction and lowest valence region may emerge in the anchored structures. The van der Waals interaction together with the electrostatic interactions due to the polarity of the surface bonds are found to be important for the structure parameters and energy stability. PMID:27392014

  8. Organization, 'Anchoring' of Knowledge, and Innovative Activity in Construction

    DEFF Research Database (Denmark)

    Drejer, Ina; Vinding, Anker Lund

    2006-01-01

    The construction industry is characterised by the widespread use of project organisation. It has been suggested that the relatively low level of innovative activity in the industry can be explained by the temporary nature of firm boundary-crossing projects. Survey data from the Danish construction...... industry is used to investigate the importance of learning and 'anchoring' of project-specific knowledge at the firm level for participation in innovative activities. The data cover both the overall Danish construction industry and a specific region, North Jutland, which has a relatively high...... specialisation of construction workers. Latent class and regression analyses reveal that firms that make extensive use of partnering, together with internal product and process evaluation and knowledge diffusion (labelled 'knowledge-anchoring mechanisms'), are more likely to participate in innovative activities...

  9. Dithiocarbamate Anchoring in Molecular Wire Junctions: A First Principles Study

    OpenAIRE

    Li, Zhenyu; Kosov, D. S.

    2007-01-01

    Recent experimental realization [J. Am. Chem. Soc., 127 (2005) 7328] of various dithiocarbamate self assembly on gold surface opens the possibility for use of dithiocarbamate linkers to anchor molecular wires to gold electrodes. In this paper, we explore this hypothesis computationally. We computed the electron transport properties of 4,4'-bipyridine (BP), 4,4'-bipyridinium-1,1'-bis(carbodithioate) (BPBC), 4-(4'-pyridyl)-peridium-1-carbodithioate (BPC) molecule junctions based on the density ...

  10. Endoplasmic reticulum anchored heme-oxygenase 1 faces the cytosol

    OpenAIRE

    Gottlieb, Yehonatan; Truman, Marianna; Cohen, Lyora A.; Leichtmann-Bardoogo, Yael; Meyron-Holtz, Esther G.

    2012-01-01

    Heme-oxygenase 1 is an endoplasmic reticulum-anchored enzyme that breaks down heme into iron, carbon monoxide and biliverdin. Heme is a hydrophobic co-factor in many proteins, including hemoglobin. Free heme is highly cytotoxic and, therefore, both heme synthesis and breakdown are tightly regulated. During turnover of heme proteins, heme is released in the phago-lysosomal compartment or the cytosol. The subcellular location of the heme-oxygenase 1 active site has not been clarified. Using con...

  11. Indoor Pedestrian Positioning Tracking Algorithm with Sparse Anchor Nodes

    OpenAIRE

    Zhou Yong; Cai Zehui; Chen Pengpeng

    2013-01-01

    In order to solve the indoor pedestrian positioning and tracking problems under the condition of sparse anchor nodes, this paper presents a new tracking scheme which predicts the staff position under the condition of indoor location fingerprints based on particle filter. In the proposed algorithm, the indoor topology is adopted to constrain and correct the results. Simulation results show that the proposed algorithm can significantly improve the accuracy of indoor pedestrian positioning and t...

  12. PredGPI: a GPI-anchor predictor

    Directory of Open Access Journals (Sweden)

    Casadio Rita

    2008-09-01

    Full Text Available Abstract Background Several eukaryotic proteins associated to the extracellular leaflet of the plasma membrane carry a Glycosylphosphatidylinositol (GPI anchor, which is linked to the C-terminal residue after a proteolytic cleavage occurring at the so called ω-site. Computational methods were developed to discriminate proteins that undergo this post-translational modification starting from their aminoacidic sequences. However more accurate methods are needed for a reliable annotation of whole proteomes. Results Here we present PredGPI, a prediction method that, by coupling a Hidden Markov Model (HMM and a Support Vector Machine (SVM, is able to efficiently predict both the presence of the GPI-anchor and the position of the ω-site. PredGPI is trained on a non-redundant dataset of experimentally characterized GPI-anchored proteins whose annotation was carefully checked in the literature. Conclusion PredGPI outperforms all the other previously described methods and is able to correctly replicate the results of previously published high-throughput experiments. PredGPI reaches a lower rate of false positive predictions with respect to other available methods and it is therefore a costless, rapid and accurate method for screening whole proteomes.

  13. The anchor of the frameless intrauterine device does not migrate over time: an analysis in over 300 women

    Directory of Open Access Journals (Sweden)

    Wildemeersch D

    2014-12-01

    Full Text Available Dirk Wildemeersch,1 Ansgar Pett,2 Sohela Jandi,2 Kilian Nolte,3 Wolfgang Albrecht4 1Gynecological Outpatient Clinic and IUD Training Centre, Ghent, Belgium; 2Gynecological Outpatient Clinic, Berlin, Germany; 3Gynecological Outpatient Clinic, Uetze, Germany; 4Gynecological Outpatient Clinic, Feldkirchen, Austria Objective: To evaluate the correct position of the anchor at insertion and follow-up and assess if migration of the anchor occurs over time. Materials and methods: This was an insertion-related, prospective, postmarketing study in 309 women. Following insertion, women were followed up at 4–6 weeks, 6 months, and yearly thereafter. The position of the visualized anchor in the fundus of the uterus was evaluated using ultrasound by measuring its distance from the serosal surface of the uterus (SA-distance. Results: A total of 309 parous (n=115 and nulliparous (n=194 women were fitted with the frameless GyneFix 200 or the GyneFix 330 intrauterine device for contraception. The mean SA-distance in 306 parous and nulliparous women was 6.0 mm (range 2.0–24.0 mm at insertion in the parous group and 5.4 mm (range 1.3–11.0 mm in the nulliparous group. At the first follow-up in 281 women, the SA-distance was 6.0 mm (range 2.0–12.0 mm in the parous group and 5.5 mm (range 1.1–11.0 mm in the nulliparous group. The SA-distance was not significantly different. One patient had an exceptionally large SA-distance of 24 mm, probably due to insertion in the posterior wall. No follow-up could be done in this patient. In 77 women, the SA-distance was measured up to 42 months. The mean SA-distance at insertion in the parous group was 5.2 mm (range 3.0–8.5 mm and 4.8 mm (range 1.3–7.0 mm in the nulliparous group. At the last follow-up up to 36 months or longer, the SA-distance was 5.1 mm (range 3.0–8.5 mm in the parous group and 4.9 mm (range 1.3–7.0 mm in the nulliparous group. The SA-distance was not significantly different. The visualized

  14. Controlling the Adsorption of Ruthenium Complexes on Carbon Surfaces through Noncovalent Bonding with Pyrene Anchors: An Electrochemical Study.

    Science.gov (United States)

    Kohmoto, Mayuko; Ozawa, Hiroaki; Yang, Li; Hagio, Toshihiro; Matsunaga, Mariko; Haga, Masa-Aki

    2016-05-01

    Surface modifications of carbon nanomaterials, such as graphene or carbon nanotubes, through noncovalent π-π interactions between π-conjugated carbon surfaces and pyrene anchors have received much attention on account of the applications of these materials in organic electronic and sensor devices. Despite the rapidly expanding use of pyrene anchors, little is known about the number of pyrene groups required in order to achieve a stable attachment of molecules on nanocarbon surfaces. So far, systematic studies on such surface modifications through adsorption isotherms and desorption behavior of molecules still remain scarce. In this study, we have investigated the effect of the number of pyrene anchors in redox-active Ru complexes on their adsorption on carbon nanomaterials through noncovalent π-π interactions. The Ru(II/III) couple was used as a redox marker in order to determine the surface coverage on nanocarbon surfaces such as highly oriented pyrolytic graphite (HOPG), single-walled carbon nanotubes (SWCNTs), and multiwalled carbon nanotubes (MWCNTs). The amount of surface coverage as well as the kinetic stability of the Ru complexes was thereby observed to be directly proportional to the number of pyrene groups present in the ligands. The desorption rate from HOPG electrode increased in the order Ru-1 with eight pyrene groups (k = 2.0 × 10(-5) s(-1)) compounds having more than two and/or optimally four pyrene groups revealed a stable adsorption on the nanocarbon surfaces. The heterogeneous electron transfer rate between the Ru complex, Ru-2, and the carbon nanomaterials increased in the order SWCNTs (kET = 1.3 s(-1)) < MWCNTs (ϕ = 5-9 nm) (kET = 4.0 s(-1)) < MWCNTs (ϕ = 110-170 nm) (kET = 14.9 s(-1)) < HOPG (kET = 110 s(-1)). PMID:27065057

  15. Parameter Sensitivity Analysis on Deformation of Composite Soil-Nailed Wall Using Artificial Neural Networks and Orthogonal Experiment

    OpenAIRE

    Jianbin Hao; Banqiao Wang

    2014-01-01

    Based on the back-propagation algorithm of artificial neural networks (ANNs), this paper establishes an intelligent model, which is used to predict the maximum lateral displacement of composite soil-nailed wall. Some parameters, such as soil cohesive strength, soil friction angle, prestress of anchor cable, soil-nail spacing, soil-nail diameter, soil-nail length, and other factors, are considered in the model. Combined with the in situ test data of composite soil-nail wall reinforcement engi...

  16. Not all nutrition claims are perceived equal: anchoring effects and moderating mechanisms in food advertising.

    Science.gov (United States)

    Paek, Hye-Jin; Yoon, Hye Jin; Hove, Thomas

    2011-03-01

    Despite the increased use of health claims in food advertising, few studies have investigated how specific nutrition claims have differential effects depending on how they are presented. In this context, the current study tests the anchoring hypothesis. Anchoring refers to a common human tendency to evaluate information differently depending on the presence or absence of a numerical "anchor" or reference point. Two (pilot and main) experimental studies explore anchoring effects on audience response to food advertising both directly and moderated by cognitive, motivational, and message factors. The pilot study finds that food product ads employing nutrition claims with an anchor rather than without an anchor generate two results: First, participants perceive the product to have lower fat/lower calorie contents (anchoring hypothesis); second, they prefer the messages with an anchor over those without an anchor. The main study reports that when anchoring is successfully evoked, it produces favorable attitudes toward the ad, favorable attitudes toward the brand, and purchase intention-but only when moderated by health orientation, claim believability, and nutrition knowledge. Practical implications are provided with respect to regulatory guidelines and effective communication strategies for promoting low-fat and low-calorie products in food advertising. PMID:21308579

  17. Domain Walls on Singularities

    CERN Document Server

    Halyo, Edi

    2009-01-01

    We describe domain walls that live on $A_2$ and $A_3$ singularities. The walls are BPS if the singularity is resolved and non--BPS if it is deformed and fibered. We show that these domain walls may interpolate between vacua that support monopoles and/or vortices.

  18. Anchoring a Lexicalized Tree-Adjoining Grammar for Discourse

    CERN Document Server

    Webber, Bryan R; Webber, Bonnie Lynn; Joshi, Aravind K.

    1998-01-01

    We here explore a ``fully'' lexicalized Tree-Adjoining Grammar for discourse that takes the basic elements of a (monologic) discourse to be not simply clauses, but larger structures that are anchored on variously realized discourse cues. This link with intra-sentential grammar suggests an account for different patterns of discourse cues, while the different structures and operations suggest three separate sources for elements of discourse meaning: (1) a compositional semantics tied to the basic trees and operations; (2) a presuppositional semantics carried by cue phrases that freely adjoin to trees; and (3) general inference, that draws additional, defeasible conclusions that flesh out what is conveyed compositionally.

  19. Direct imaging of rotating molecules anchored on graphene

    Science.gov (United States)

    Choe, Jeongheon; Lee, Yangjin; Fang, Lei; Lee, Gun-Do; Bao, Zhenan; Kim, Kwanpyo

    2016-07-01

    There has been significant research interest in controlling and imaging molecular dynamics, such as translational and rotational motions, especially at a single molecular level. Here we applied aberration-corrected transmission electron microscopy (ACTEM) to actuate and directly image the rotational motions of molecules anchored on a single-layer-graphene sheet. Nanometer-sized carbonaceous molecules anchored on graphene provide ideal systems for monitoring rotational motions via ACTEM. We observed the preferential registry of longer molecular axis along graphene zigzag or armchair lattice directions due to the stacking-dependent molecule-graphene energy landscape. The calculated cross section from elastic scattering theory was used to experimentally estimate the rotational energy barriers of molecules on graphene. The observed energy barrier was within the range of 1.5-12 meV per atom, which is in good agreement with previous calculation results. We also performed molecular dynamics simulations, which revealed that the edge atoms of the molecule form stably bonds to graphene defects and can serve as a pivot point for rotational dynamics. Our study demonstrates the versatility of ACTEM for the investigation of molecular dynamics and configuration-dependent energetics at a single molecular level.There has been significant research interest in controlling and imaging molecular dynamics, such as translational and rotational motions, especially at a single molecular level. Here we applied aberration-corrected transmission electron microscopy (ACTEM) to actuate and directly image the rotational motions of molecules anchored on a single-layer-graphene sheet. Nanometer-sized carbonaceous molecules anchored on graphene provide ideal systems for monitoring rotational motions via ACTEM. We observed the preferential registry of longer molecular axis along graphene zigzag or armchair lattice directions due to the stacking-dependent molecule-graphene energy landscape. The

  20. Analytical Model for Hook Anchor Pull-Out

    DEFF Research Database (Denmark)

    Brincker, Rune; Ulfkjær, Jens Peder; Adamsen, Peter; Langvad, Lotte; Toft, Rune

    A simple analytical model for the pull-out of a hook anchor is presented. The model is based on a simplified version of the fictitious crack model. It is assumed that the fracture process is the pull-off of a cone shaped concrete part, simplifying the problem by assuming pure rigid body motions...... allowing elastic deformations only in a layer between the pull-out cone and the concrete base. The derived model is in good agreement with experimental results, it predicts size effects and the model parameters found by calibration of the model on experimental data are in good agreement with what should be...

  1. Models for Anchoring and Acquiescence Bias in Consumption Data

    OpenAIRE

    van Soest, A.H.O.; Hurd, M.

    2004-01-01

    Item non-response in household survey data on economic variables such as income, assets or consumption is a well-known problem. Follow-up unfolding bracket questions have been used as a tool to collect partial information on respondents that do not answer an open-ended question. It is also known, however, that mistakes are made in answering such unfolding bracket questions. In this paper, we develop several limited dependent variable models to analyze two sources of mistakes, anchoring and ac...

  2. Different size biomolecules anchoring on porous silicon surface: fluorescence and reflectivity pores infiltration comparative studies

    Energy Technology Data Exchange (ETDEWEB)

    Giovannozzi, Andrea M.; Rossi, Andrea M. [National Institute for Metrological Research, Thermodynamic Division, Strada delle Cacce 91, 10135 Torino (Italy); Renacco, Chiara; Farano, Alessandro [Ribes Ricecrhe Srl, Via Lavoratori Vittime del Col du Mont 24, 11100 Aosta (Italy); Derosas, Manuela [Biodiversity Srl, Via Corfu 71, 25124 Brescia (Italy); Enrico, Emanuele [National Institute for Metrological Research, Electromagnetism Division, Strada delle Cacce 91, 10135 Torino (Italy)

    2011-06-15

    The performance of porous silicon optical based biosensors strongly depends on material nanomorphology, on biomolecules distribution inside the pores and on the ability to link sensing species to the pore walls. In this paper we studied the immobilization of biomolecules with different size, such as antibody anti aflatoxin (anti Aflatox Ab, {proportional_to}150 KDa), malate dehydrogenase (MDH, {proportional_to}36KDa) and metallothionein (MT, {proportional_to}6KDa) at different concentrations on mesoporous silicon samples ({proportional_to}15 nm pores diameter). Fluorescence measurements using FITC- labeled biomolecules and refractive index analysis based on reflectivity spectra have been employed together to detect the amount of proteins bound to the surface and to evaluate their diffusion inside the pores. Here we suggest that these two techniques should be used together to have a better understanding of what happens at the porous silicon surface. In fact, when pores dimensions are not perfectly tuned to the protein size a higher fluorescence signal doesn't often correspond to a higher biomolecules distribution inside the pores. When a too much higher concentration of biomolecule is anchored on the surface, steric crowd effects and repulsive interactions probably take over and hinder pores infiltration, inducing a small or absent shift in the fringe pattern even if a higher fluorescence signal is registered. (copyright 2011 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  3. Covalent functionalization of multi-walled carbon nanotubes by lipase

    International Nuclear Information System (INIS)

    Lipase from Candida rugosa was covalently anchored onto acid-treated multi-walled carbon nanotubes (MWNTs) through a self-catalytic mechanism. A variety of characterization techniques including FTIR, Raman spectroscopy, and XPS were employed to demonstrate the formation of the ester linkage between lipase and MWNTs. The MWNTs-lipase biocomposites showed significantly increased solubility in some common-used organic solvents, such as THF, DMF and chloroform. This study may offer a novel and facile route for covalent modification of carbon nanotubes, and expand the potential utilization of both lipases and MWNTs in the fields of biocatalyst and biosensor

  4. Membrane curvature enables N-Ras lipid anchor sorting to liquid-ordered membrane phases

    DEFF Research Database (Denmark)

    Larsen, Jannik Bruun; Jensen, Martin Borch; Bhatia, Vikram Kjøller;

    2015-01-01

    Trafficking and sorting of membrane-anchored Ras GTPases are regulated by partitioning between distinct membrane domains. Here, in vitro experiments and microscopic molecular theory reveal membrane curvature as a new modulator of N-Ras lipid anchor and palmitoyl chain partitioning. Membrane...... curvature was essential for enrichment in raft-like liquid-ordered phases; enrichment was driven by relief of lateral pressure upon anchor insertion and most likely affects the localization of lipidated proteins in general....

  5. An internally positioned signal can direct attachment of a glycophospholipid membrane anchor

    OpenAIRE

    1991-01-01

    All known glycophosphatidylinositol (GPI)-anchored membrane proteins contain a COOH-terminal hydrophobic domain necessary for signalling anchor attachment. To examine the requirement that this signal be at the COOH terminus of the protein, we constructed a chimeric protein, DAFhGH, in which human growth hormone (hGH) was fused to the COOH terminus of decay accelerating factor (DAF) (a GPI-anchored protein), thereby placing the GPI signal in the middle of the chimeric protein. We show that the...

  6. A glycophospholipid membrane anchor acts as an apical targeting signal in polarized epithelial cells

    OpenAIRE

    1989-01-01

    Glycosyl-phosphatidylinositol- (GPI) anchored proteins contain a large extracellular protein domain that is linked to the membrane via a glycosylated form of phosphatidylinositol. We recently reported the polarized apical distribution of all endogenous GPI-anchored proteins in the MDCK cell line (Lisanti, M. P., M. Sargiacomo, L. Graeve, A. R. Saltiel, and E. Rodriguez-Boulan. 1988. Proc. Natl. Acad. Sci. USA. 85:9557-9561). To study the role of this mechanism of membrane anchoring in targeti...

  7. Model Test of Anchoring Effect on Zonal Disintegration in Deep Surrounding Rock Masses

    OpenAIRE

    Xu-Guang Chen; Qiang-Yong Zhang; Yuan Wang; De-Jun Liu; Ning Zhang

    2013-01-01

    The deep rock masses show a different mechanical behavior compared with the shallow rock masses. They are classified into alternating fractured and intact zones during the excavation, which is known as zonal disintegration. Such phenomenon is a great disaster and will induce the different excavation and anchoring methodology. In this study, a 3D geomechanics model test was conducted to research the anchoring effect of zonal disintegration. The model was constructed with anchoring in a half an...

  8. Nothing so certain as your anchors? A consumer bias that might lower prices

    OpenAIRE

    Bakó, Barna; Kálecz-Simon, András

    2014-01-01

    Anchoring is a well-known decision-making bias: original guesses for a certain question could act as anchors and could influence our final answers. Reference prices - in a similar fashion - can lead to a bias in consumer valuations, and thus consumer demand will be coherent but not one derived from a utility framework. In our paper we investigate the effect of the existence of anchoring on how oligopolistic firms might change their pricing strategy. More specifically, we analyze the effec...

  9. Post-installed concrete anchors in nuclear power plants: Performance and qualification

    International Nuclear Information System (INIS)

    Graphical abstract: - Highlights: • Review of qualification and design regulations for anchors in nuclear power plants. • First complete set of nuclear anchor load–displacement data and its evaluation ever. • Demonstration of robust test behavior of a qualified post-installed anchor product. - Abstract: In nuclear power plants (NPPs), post-installed anchors are widely used for structural and non-structural connections to concrete. In many countries, anchor products employed for safety relevant applications have to be approved by the authorities. For the high safety standards in force for NPPs, special requirements have to be met to allow for extreme design situations. This paper presents an experimental test program conducted to evaluate the performance of anchors according to the German Guideline for Anchorages in Nuclear Power Plants and Nuclear Technology Installations (DIBt KKW Leitfaden, 2010). After a brief introduction to anchor behavior and the regulative context, the results of tension and shear tests carried out on undercut anchors are discussed. Robust load capacities and relatively small displacements determined for demanding load and crack cycling tests demonstrated the suitability of anchors qualified according to a state-of-the-art qualification guideline

  10. The biggest stone anchors (Indo-Arab type) from Mithi Virdi, Bhavnagar, west coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Gaur, A.S.; Sundaresh; Kumar, B.

    as Bhima Ka Khatiya ('Cot of Bhima'), was discovered near the village of Mithi Virdi. Here, five grapnel type of stone anchors were noticed lying in a field. The lower two holes of the grapnel anchors on either face of the section of stone block... been cut from conglomeratic sedimentary grit rock, which is dark brown in colour and small gravel can be noticed. The anchors have only lower two rectangular holes and the upper circular hole is absent in all the anchors. A brief description...

  11. Theoretical model and solution for the rheological problem of anchor-grouting a soft rock tunnel

    International Nuclear Information System (INIS)

    The paper presents an analytical method for analysis of the soft rock tunnel, based on a model dividing soft rock tunnels into a region of anchor-grouting and a region of non-anchor-grouting surrounding rock. The Poynting-Thomson model and the Kelvin-Hooke model are applied to the region of non-anchor-grouting surrounding rock and the region of anchor-grouting, respectively. Stress expressions in the region of non-anchor-grouting surrounding rock and the region of anchor-grouting are obtained. Expanding the expression of displacements in the region of anchor-grouting into a Maclaurin series, and utilizing the cumulative displacement curve of the surrounding rock through observation, a theoretical model is set up. This model and its solution for the rheology problem of anchor-grouting a soft tunnel have been proved to be effective in practical engineering; according to the Mohr-Coulomb yield condition, a safe criterion for an anchor-grouting soft rock of a tunnel can be found

  12. Radiocarbon dates of the medieval period stone anchors from Dabhol, west coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Gaur, A.S.; Sundaresh; Tripati, S.; Vora, K.H.

    dredging operation in Dabhol creek. the anchors are lying in front of the Cus- tom Office of Dabhol. One of the anchors had wooden fluke remains in the holes, which were removed and kept safely by an active social worker at Dabhol. These anchors.... The calibrated date of the first sam- ple ranged between 654 and 524 yrs BP, and the second sample ranged between 653 and 537 yrs BP (Table 2). Discussion The discovery of anchors from the Dab- hol creek is one of the significant find- ings to support...

  13. Dithiocarbamate anchoring in molecular wire junctions: a first principles study.

    Science.gov (United States)

    Li, Zhenyu; Kosov, Daniel S

    2006-05-25

    Recent experimental realization [J. Am. Chem. Soc., 127 (2005) 7328] of various dithiocarbamate self-assembly on gold surface opens the possibility for use of dithiocarbamate linkers to anchor molecular wires to gold electrodes. In this paper, we explore this hypothesis computationally. We computed the electron transport properties of 4,4'-bipyridine (BP), 4,4'-bipyridinium-1,1'-bis(carbodithioate) (BPBC), 4-(4'-pyridyl)-peridium-1-carbodithioate (BPC) molecule junctions based on the density functional theory and nonequilibrium Green's functions. We demonstrated that the stronger molecule-electrode coupling associated with the conjugated dithiocarbamate linker broadens transmission resonances near the Fermi energy. The broadening effect along with the extension of the pi conjugation from the molecule to the gold electrodes lead to enhanced electrical conductance for BPBC molecule. The conductance enhancement factor is as large as 25 at applied voltage bias 1.0 V. Rectification behavior is predicted for BPC molecular wire junction, which has the asymmetric anchoring groups. PMID:16706444

  14. Adaptive anchored inversion for Gaussian random fields using nonlinear data

    International Nuclear Information System (INIS)

    In a broad and fundamental type of ‘inverse problems’ in science, one infers a spatially distributed physical attribute based on observations of processes that are controlled by the spatial attribute in question. The data-generating field processes, known as ‘forward processes’, are usually nonlinear with respect to the spatial attribute, and are often defined non-analytically by a numerical model. The data often contain a large number of elements with significant inter-correlation. We propose a general statistical method to tackle this problem. The method is centered on a parameterization device called ‘anchors’ and an iterative algorithm for deriving the distribution of anchors conditional on the observed data. The algorithm draws upon techniques of importance sampling and multivariate kernel density estimation with weighted samples. Anchors are selected automatically; the selection evolves in iterations in a way that is tailored to important features of the attribute field. The method and the algorithm are general with respect to the scientific nature and technical details of the forward processes. Conceptual and technical components render the method in contrast to standard approaches that are based on regularization or optimization. Some important features of the proposed method are demonstrated by examples from the earth sciences, including groundwater flow, rainfall-runoff and seismic tomography. (paper)

  15. Direct imaging of rotating molecules anchored on graphene.

    Science.gov (United States)

    Choe, Jeongheon; Lee, Yangjin; Fang, Lei; Lee, Gun-Do; Bao, Zhenan; Kim, Kwanpyo

    2016-07-21

    There has been significant research interest in controlling and imaging molecular dynamics, such as translational and rotational motions, especially at a single molecular level. Here we applied aberration-corrected transmission electron microscopy (ACTEM) to actuate and directly image the rotational motions of molecules anchored on a single-layer-graphene sheet. Nanometer-sized carbonaceous molecules anchored on graphene provide ideal systems for monitoring rotational motions via ACTEM. We observed the preferential registry of longer molecular axis along graphene zigzag or armchair lattice directions due to the stacking-dependent molecule-graphene energy landscape. The calculated cross section from elastic scattering theory was used to experimentally estimate the rotational energy barriers of molecules on graphene. The observed energy barrier was within the range of 1.5-12 meV per atom, which is in good agreement with previous calculation results. We also performed molecular dynamics simulations, which revealed that the edge atoms of the molecule form stably bonds to graphene defects and can serve as a pivot point for rotational dynamics. Our study demonstrates the versatility of ACTEM for the investigation of molecular dynamics and configuration-dependent energetics at a single molecular level. PMID:27333828

  16. Impact of fuel composition on the recirculation zone structure and its role in lean premixed flame anchoring

    KAUST Repository

    Hong, Seunghyuck

    2015-01-01

    © 2014 The Combustion Institute. Published by Elsevier Inc. All rights reserved. We investigate the dependence of the recirculation zone (RZ) size and structure on the fuel composition using high-speed particle image velocimetry (PIV) and chemiluminescence measurements for C3H8/H2/air lean premixed flames stabilized in a backward-facing step combustor. Results show an intricate coupling between the flame anchoring and the RZ structure and length. For a fixed fuel composition, at relatively low equivalence ratios, the time-averaged RZ is comprised of two counter rotating eddies: a primary eddy (PE) between the shear layer and the bottom wall; and a secondary eddy (SE) between the vertical step wall and the PE. The flame stabilizes downstream of the saddle point of the dividing streamline between the two eddies. As equivalence ratio is raised, the flame moves upstream, pushing the saddle point with it and reducing the size of the SE. Higher temperature of the products reduces the velocity gradient in the shear layer and thus the reattachment length. As equivalence ratio approaches a critical value, the saddle point reaches the step and the SE collapses while the flame starts to exhibit periodic flapping motions, suggesting a correlation between the RZ structure and flame anchoring. The overall trend in the flow field is the same as we add hydrogen to the fuel at a fixed equivalence ratio, demonstrating the impact of fuel composition on the flow field. We show that the reattachment lengths (LR), which are shown to encapsulate the mean RZ structure, measured over a range of fuel composition and equivalence ratio collapse if plotted against the strained consumption speed (Sc). Results indicate that for the flame to remain anchored, the RZ structure should satisfy lR,isothermal/L R,reacting · S c/U ∞ ∼ 0.1. If this criterion cannot be met, the flame blows off, flashes back or becomes thermoacoustically unstable, suggesting a Damköhler-like criterion for

  17. C-Anchor for Strengthening the Connection between Adhesively Bonded Laminates and Concrete Substrates

    Directory of Open Access Journals (Sweden)

    Ghani Razaqpur

    2015-11-01

    Full Text Available A new carbon fiber reinforced polymer (CFRP anchor is developed and tested to delay debonding in reinforced concrete (RC beams externally strengthened with FRP laminate/sheet. The C-shape anchor is made from a commercially available CFRP grid. The anchors legs are 95 mm long while the spacing between the legs is adjustable, depending on FRP laminate and beam widths. Nine full scale RC beams, 3.0 m long, 250 mm wide and 400 mm deep, were strengthened with CFRP laminate/sheet, with and without the C-anchor. The main test parameters were the type and amount of FRP laminate and the presence/absence of the anchor. Test results showed that beams with the anchor had generally 5%–10% higher debonding and failure load, and they reached higher deflection at failure than the companion beams without anchors. Although complete separation of the FRP laminate from the concrete was not observed in any of the beams with anchors, there was noticeable slip at failure at one end of the laminate. A significant outcome of the study is that anchors are effective in limiting the extent of debonding along the laminate, thus contributing to the flexural stiffness of the beam by reducing the extent of cracking and limiting the crack width along the beam. Finally, the anchor allowed the FRP to reach or exceed its theoretically allowable strain computed based on the American Concrete Institute (ACI Committee 440 recommendation while in none of the beams without anchors, the FRP reached its theoretically allowable strain.

  18. Impingement syndrome of the shoulder following double row suture anchor technique for arthroscopic rotator cuff repair: a case report

    Directory of Open Access Journals (Sweden)

    Rambani Rohit

    2009-06-01

    Full Text Available Abstract Introduction Arthroscopic repair of the rotator cuff is a demanding surgery. Accurate placement of anchors is key to success. Case presentation A 38-year-old woman received arthroscopic repair of her rotator cuff using a double row suture anchor technique. Postoperatively, she developed impingement syndrome which resulted from vertical displacement of a suture anchor once the shoulder was mobilised. The anchor was removed eight weeks following initial surgery and the patient had an uneventful recovery. Conclusion Impingement syndrome following arthroscopic repair of the rotator cuffs using double row suture anchor has not been widely reported. This is the first such case where anchoring has resulted in impingement syndrome.

  19. Experimental study and advanced CFD simulation of fire safety performance of building external wall insulation system

    OpenAIRE

    Yan Zhenghua; Zhao Chenggang; Liu Yan; Deng Xiaobing; Ceng Xubin; Liu Songlin; Lan Bin; Nilsson Richard; Jeansson Sebastian

    2013-01-01

    Large scale fire tests of building external wall insulation system were conducted. In the experiment, thermal-couples were mounted to measure the insulation system surface temperature and the gas temperature inside rooms at the second and third floors. Photos were also taken during the fire tests. The measurement provides information of the ignition and fire spread of the external insulation system which consists of surface protection layer, glass fibre net, bonding thin layer, anchor and the...

  20. Retrofit of Thin-walled Steel Tanks for Low Liquid Level Operation

    OpenAIRE

    C. Maraveas , K. Miamis

    2013-01-01

    The safe operation of steel oil storage tanks is vital for the petroleum industry. Such tanks are typically thin-walled, cylindrical, with large diameters and are not mechanically anchored to the foundation. Until recently, code provisions were oriented towards the design of tanks operating at high levels of the contained liquid and emphasis was given on preventing failure modes associated with yielding of the shell (plastic limit state). Based on this concept, the majority of the existing ta...

  1. Preliminary design and parametric study of 1400 m partially earth-anchored cable-stayed bridge

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    The preliminary design and parametric study of 1400 m partially earth-anchored cable-stayed bridge are described. Static per-formance of this new type of bridge is discussed. Compared with fully self-anchored cable-stayed bridge, its advantages in fin-ished state are summarized. Based on numerical calculation, effects of several structural parameters on static performance are presented.

  2. Structural models of the membrane anchors of envelope glycoproteins E1 and E2 from pestiviruses

    International Nuclear Information System (INIS)

    The membrane anchors of viral envelope proteins play essential roles in cell entry. Recent crystal structures of the ectodomain of envelope protein E2 from a pestivirus suggest that E2 belongs to a novel structural class of membrane fusion machinery. Based on geometric constraints from the E2 structures, we generated atomic models of the E1 and E2 membrane anchors using computational approaches. The E1 anchor contains two amphipathic perimembrane helices and one transmembrane helix; the E2 anchor contains a short helical hairpin stabilized in the membrane by an arginine residue, similar to flaviviruses. A pair of histidine residues in the E2 ectodomain may participate in pH sensing. The proposed atomic models point to Cys987 in E2 as the site of disulfide bond linkage with E1 to form E1–E2 heterodimers. The membrane anchor models provide structural constraints for the disulfide bonding pattern and overall backbone conformation of the E1 ectodomain. - Highlights: • Structures of pestivirus E2 proteins impose constraints on E1, E2 membrane anchors. • Atomic models of the E1 and E2 membrane anchors were generated in silico. • A “snorkeling” arginine completes the short helical hairpin in the E2 membrane anchor. • Roles in pH sensing and E1–E2 disulfide bond formation are proposed for E1 residues. • Implications for E1 ectodomain structure and disulfide bonding pattern are discussed

  3. An Anchor-Based Pedestrian Navigation Approach Using Only Inertial Sensors.

    Science.gov (United States)

    Gu, Yang; Song, Qian; Li, Yanghuan; Ma, Ming; Zhou, Zhimin

    2016-01-01

    In inertial-based pedestrian navigation, anchors can effectively compensate the positioning errors originating from deviations of Inertial Measurement Units (IMUs), by putting constraints on pedestrians' motions. However, these anchors often need to be deployed beforehand, which can greatly increase system complexity, rendering it unsuitable for emergency response missions. In this paper, we propose an anchor-based pedestrian navigation approach without any additional sensors. The anchors are defined as the intersection points of perpendicular corridors and are considered characteristics of building structures. In contrast to these real anchors, virtual anchors are extracted from the pedestrian's trajectory and are considered as observations of real anchors, which can accordingly be regarded as inferred building structure characteristics. Then a Rao-Blackwellized particle filter (RBPF) is used to solve the joint estimation of positions (trajectory) and maps (anchors) problem. Compared with other building structure-based methods, our method has two advantages. The assumption on building structure is minimum and valid in most cases. Even if the assumption does not stand, the method will not lead to positioning failure. Several real-scenario experiments are conducted to validate the effectiveness and robustness of the proposed method. PMID:26959031

  4. Model test of anchoring effect on zonal disintegration in deep surrounding rock masses.

    Science.gov (United States)

    Chen, Xu-Guang; Zhang, Qiang-Yong; Wang, Yuan; Liu, De-Jun; Zhang, Ning

    2013-01-01

    The deep rock masses show a different mechanical behavior compared with the shallow rock masses. They are classified into alternating fractured and intact zones during the excavation, which is known as zonal disintegration. Such phenomenon is a great disaster and will induce the different excavation and anchoring methodology. In this study, a 3D geomechanics model test was conducted to research the anchoring effect of zonal disintegration. The model was constructed with anchoring in a half and nonanchoring in the other half, to compare with each other. The optical extensometer and optical sensor were adopted to measure the displacement and strain changing law in the model test. The displacement laws of the deep surrounding rocks were obtained and found to be nonmonotonic versus the distance to the periphery. Zonal disintegration occurs in the area without anchoring and did not occur in the model under anchoring condition. By contrasting the phenomenon, the anchor effect of restraining zonal disintegration was revealed. And the formation condition of zonal disintegration was decided. In the procedure of tunnel excavation, the anchor strain was found to be alternation in tension and compression. It indicates that anchor will show the nonmonotonic law during suppressing the zonal disintegration. PMID:23997683

  5. The glycosylphosphatidylinositol-anchored protein repertoire of babesia bovis and its significance for erythrocyte invasion

    Science.gov (United States)

    Glycosylphosphatidyl-anchored proteins are particularly abundant on the surface of pathogenic protozoans and might play an important role for parasite survival. In the present work the relevance of GPI-anchored proteins for erythrocyte invasion of Babesia bovis, one of the tick-transmitted causative...

  6. Unintended anchors: Building rating systems and energy performance goals for U.S. buildings

    International Nuclear Information System (INIS)

    In the U.S., where buildings account for 40% of energy use, commercial buildings use more energy per unit area than ever before. However, exemplary buildings demonstrate the feasibility of much better energy performance at no additional first cost. This research examines one possible explanation for this inconsistency. The aim is to investigate whether the anchoring bias, which refers to our tendency to gravitate towards a pre-defined standard regardless of its relevance, influences energy performance goals in building design. The scope examines professionals who help set energy performance goals for U.S. buildings. Prior to being asked to set an energy performance goal, these professionals were randomly directed to one of three series of questions. One series set an anchor of 90% energy reduction beyond standard practice, one set a 30% anchor, and one set no anchor. Respondents exposed to the 90% anchor, and respondents exposed to no anchor at all, set higher energy performance goals than respondents exposed to the 30% anchor. These results suggest that building rating systems that only reward incremental energy improvements may inadvertently create anchors, thereby discouraging more advanced energy performance goals and inhibiting energy performance that is technically and economically feasible.

  7. Structural models of the membrane anchors of envelope glycoproteins E1 and E2 from pestiviruses

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Jimin, E-mail: jimin.wang@yale.edu; Li, Yue; Modis, Yorgo, E-mail: yorgo.modis@yale.edu

    2014-04-15

    The membrane anchors of viral envelope proteins play essential roles in cell entry. Recent crystal structures of the ectodomain of envelope protein E2 from a pestivirus suggest that E2 belongs to a novel structural class of membrane fusion machinery. Based on geometric constraints from the E2 structures, we generated atomic models of the E1 and E2 membrane anchors using computational approaches. The E1 anchor contains two amphipathic perimembrane helices and one transmembrane helix; the E2 anchor contains a short helical hairpin stabilized in the membrane by an arginine residue, similar to flaviviruses. A pair of histidine residues in the E2 ectodomain may participate in pH sensing. The proposed atomic models point to Cys987 in E2 as the site of disulfide bond linkage with E1 to form E1–E2 heterodimers. The membrane anchor models provide structural constraints for the disulfide bonding pattern and overall backbone conformation of the E1 ectodomain. - Highlights: • Structures of pestivirus E2 proteins impose constraints on E1, E2 membrane anchors. • Atomic models of the E1 and E2 membrane anchors were generated in silico. • A “snorkeling” arginine completes the short helical hairpin in the E2 membrane anchor. • Roles in pH sensing and E1–E2 disulfide bond formation are proposed for E1 residues. • Implications for E1 ectodomain structure and disulfide bonding pattern are discussed.

  8. Analysis on the anchor mechanism of the full length resin bolt

    Institute of Scientific and Technical Information of China (English)

    宋彦波; 刘洪涛

    2003-01-01

    The purpose of this paper is to reveal the stress distribution characteristic along the full length anchor bolt. Based on the mechanic model set up, the author calculated the anchor mechanism of the full length resin rock-bolt. The stress distribution characteristic is different according to different type of surrounding-rock. The conclusion is important to optimize the roadway bolt support design.

  9. MODIFICATION OF PALLADIUM METALLIC CATALYST WITH POLYMER-ANCHORED THIOETHER LIGANDS

    Institute of Scientific and Technical Information of China (English)

    LIU Hanfan; MAO Guoping

    1993-01-01

    A well-dispersed metallic palladium catalyst modified by polymer-anchored thioether ligands was used for the hydrogenation of cyclopentadiene to cyclopentene with high activity and selectivity in ambient condition. The evidences to show the modification of catalytic properties by polymer anchored ligands were given.

  10. Model for ion confinement in a hot-electron tandem mirror anchor

    International Nuclear Information System (INIS)

    Anisotropic, hot electrons trapped in local minimum-B wells have been proposed as MHD-stabilizing anchors to an otherwise axisymmetric tandem configuration. This work describes a model for plasma confinement between the anchors and the remainder of the system and calcuates the power loss implied by maintenance of this plasma

  11. Stone anchors from Sindhudurg Fort on the west coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Tripati, S.; Gaur, A.S.

    , of which there are triangular and three grapnet-type, used to construct the jetty along with the locally available sand stone. The two remaining grapnet-type anchors are erected on the jetty for mooring purposes. It is found that none of the anchors were...

  12. Thermal anchoring of wires in large scale superconducting coil test experiment

    International Nuclear Information System (INIS)

    Highlights: • We addressed how thermal anchoring in large scale coil test is different compare to small cryogenic apparatus? • We did precise estimation of thermal anchoring length at 77 K and 4.2 K heat sink in large scale superconducting coil test experiment. • We addressed, the quality of anchoring without covering entire wires using Kapton/Teflon tape. • We obtained excellent results in temperature measurement without using GE Varnish by doubling estimated anchoring length. -- Abstract: Effective and precise thermal anchoring of wires in cryogenic experiment is mandatory to measure temperature in milikelvin accuracy and to avoid unnecessary cooling power due to additional heat conduction from room temperature (RT) to operating temperature (OT) through potential, field, displacement and stress measurement instrumentation wires. Instrumentation wires used in large scale superconducting coil test experiments are different compare to cryogenic apparatus in terms of unique construction and overall diameter/area due to errorless measurement in large time-varying magnetic field compare to small cryogenic apparatus, often shielded wires are used. Hence, along with other variables, anchoring techniques and required thermal anchoring length are entirely different in this experiment compare to cryogenic apparatus. In present paper, estimation of thermal anchoring length of five different types of instrumentation wires used in coils test campaign at Institute for Plasma Research (IPR), India has been discussed and some temperature measurement results of coils test campaign have been presented

  13. Grapnel stone anchors from Saurashtra: Remnants of Indo-Arab trade on the Indian coast

    Digital Repository Service at National Institute of Oceanography (India)

    Gaur, A.S.; Sundaresh; Tripati, S.

    used as indications of ancient trade routes and sizes of boats. Marine archaeological investigations have brought to light a large number of stone anchors occurring along the Indian coast. One of the important type is grapnel anchor which has been cut...

  14. An Indo-Arabian type of stone anchor from Kannur, Kerala,west coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Tripati, S.; Manikfan, A.; Mohamed, M.

    has revealed an Indo-Arabian type of stone anchor at Hydross Palli Mosque near the beach of Kannur (Cannanore) city of Kerala. The anchor is lying on the southeast corner of the mosque and buried on the ground. Historical records mention...

  15. Associative Self-Anchoring Interacts with Obtainability of Chosen Objects

    Science.gov (United States)

    Prévost, Charlotte; Bolger, Niall; Mobbs, Dean

    2016-01-01

    While there is evidence that implicit self-esteem transfers to chosen objects (associative self-anchoring), it is still unknown whether this phenomenon extends to explicit self-esteem. Moreover, whether the knowledge that these objects might belong to the self in the future or not affects the evaluation of these objects has received little attention. Here, we demonstrate that evaluations of chosen objects are further enhanced when they are obtainable as compared to when they are not in participants with high explicit self-esteem, whereas participants with low explicit self-esteem exhibit the opposite pattern. These findings extend previous results and shed new light on the role of self-esteem in altering preferences for chosen objects depending on their obtainability. PMID:26913011

  16. Robust conductance of dumbbell molecular junctions with fullerene anchoring groups

    DEFF Research Database (Denmark)

    Markussen, Troels; Settnes, Mikkel; Thygesen, Kristian Sommer

    2011-01-01

    The conductance of a molecular wire connected to metallic electrodes is known to be sensitive to the atomic structure of the molecule-metal contact. This contact is to a large extent determined by the anchoring group linking the molecular wire to the metal. It has been found experimentally...... against variations in the detailed bonding geometry and in good agreement with the experimental value of G= 3 × 10-4G0. Electron tunneling across the molecular bridge occurs via the lowest unoccupied orbitals of C60 which are pinned close to the Fermi energy due to partial charge transfer. Our findings...... support the original motivation to achieve conductance values more stable towards changes in the structure of the molecule-metal contact leading to larger reproducibility in experiments. © 2011 American Institute of Physics....

  17. Structural basis for membrane anchoring of HIV-1 envelope spike.

    Science.gov (United States)

    Dev, Jyoti; Park, Donghyun; Fu, Qingshan; Chen, Jia; Ha, Heather Jiwon; Ghantous, Fadi; Herrmann, Tobias; Chang, Weiting; Liu, Zhijun; Frey, Gary; Seaman, Michael S; Chen, Bing; Chou, James J

    2016-07-01

    HIV-1 envelope spike (Env) is a type I membrane protein that mediates viral entry. We used nuclear magnetic resonance to determine an atomic structure of the transmembrane (TM) domain of HIV-1 Env reconstituted in bicelles that mimic a lipid bilayer. The TM forms a well-ordered trimer that protects a conserved membrane-embedded arginine. An amino-terminal coiled-coil and a carboxyl-terminal hydrophilic core stabilize the trimer. Individual mutations of conserved residues did not disrupt the TM trimer and minimally affected membrane fusion and infectivity. Major changes in the hydrophilic core, however, altered the antibody sensitivity of Env. These results show how a TM domain anchors, stabilizes, and modulates a viral envelope spike and suggest that its influence on Env conformation is an important consideration for HIV-1 immunogen design. PMID:27338706

  18. Phosphatidylinositol anchor of HeLa cell alkaline phosphatase

    International Nuclear Information System (INIS)

    Alkaline phosphatase from cancer cells, HeLa TCRC-1, was biosynthetically labeled with either 3H-fatty acids or [3H]ethanolamine as analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and fluorography of immunoprecipitated material. Phosphatidylinositol-specific phospholipase C (PI-PLC) released a substantial proportion of the 3H-fatty acid label from immunoaffinity-purified alkaline phosphatase but had no effect on the radioactivity of [3H]ethanolamine-labeled material. PI-PLC also liberated catalytically active alkaline phosphatase from viable cells, and this could be selectively blocked by monoclonal antibodies to alkaline phosphatase. However, the alkaline phosphatase released from 3H-fatty acid labeled cells by PI-PLC was not radioactive. By contrast, treatment with bromelain removed both the 3H-fatty acid and the [3H]ethanolamine label from purified alkaline phosphatase. Subtilisin was also able to remove the [3H]ethanolamine label from the purified alkaline phosphatase. The 3H radioactivity in alkaline phosphatase purified from [3H]ethanolamine-labeled cells comigrated with authentic [3H]ethanolamine by anion-exchange chromatography after acid hydrolysis. The data suggest that the 3H-fatty acid and [3H]ethanolamine are covalently attached to the carboxyl-terminal segment since bromelain and subtilisin both release alkaline phosphatase from the membrane by cleavage at that end of the polypeptide chain. The data are consistent with findings for other proteins recently shown to be anchored in the membrane through a glycosylphosphatidylinositol structure and indicate that a similar structure contributes to the membrane anchoring of alkaline phosphatase

  19. Phosphatidylinositol anchor of HeLa cell alkaline phosphatase

    Energy Technology Data Exchange (ETDEWEB)

    Jemmerson, R.; Low, M.G.

    1987-09-08

    Alkaline phosphatase from cancer cells, HeLa TCRC-1, was biosynthetically labeled with either /sup 3/H-fatty acids or (/sup 3/H)ethanolamine as analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and fluorography of immunoprecipitated material. Phosphatidylinositol-specific phospholipase C (PI-PLC) released a substantial proportion of the /sup 3/H-fatty acid label from immunoaffinity-purified alkaline phosphatase but had no effect on the radioactivity of (/sup 3/H)ethanolamine-labeled material. PI-PLC also liberated catalytically active alkaline phosphatase from viable cells, and this could be selectively blocked by monoclonal antibodies to alkaline phosphatase. However, the alkaline phosphatase released from /sup 3/H-fatty acid labeled cells by PI-PLC was not radioactive. By contrast, treatment with bromelain removed both the /sup 3/H-fatty acid and the (/sup 3/H)ethanolamine label from purified alkaline phosphatase. Subtilisin was also able to remove the (/sup 3/H)ethanolamine label from the purified alkaline phosphatase. The /sup 3/H radioactivity in alkaline phosphatase purified from (/sup 3/H)ethanolamine-labeled cells comigrated with authentic (/sup 3/H)ethanolamine by anion-exchange chromatography after acid hydrolysis. The data suggest that the /sup 3/H-fatty acid and (/sup 3/H)ethanolamine are covalently attached to the carboxyl-terminal segment since bromelain and subtilisin both release alkaline phosphatase from the membrane by cleavage at that end of the polypeptide chain. The data are consistent with findings for other proteins recently shown to be anchored in the membrane through a glycosylphosphatidylinositol structure and indicate that a similar structure contributes to the membrane anchoring of alkaline phosphatase.

  20. The detrimental consequences for seagrass of ineffective marine park management related to boat anchoring.

    Science.gov (United States)

    La Manna, G; Donno, Y; Sarà, G; Ceccherelli, G

    2015-01-15

    Posidonia oceanica (L.) Delile meadows are recognized as priority habitat for conservation by the EU Habitats Directive. The La Maddalena Archipelago National Park (Mediterranean Sea) P. oceanica meadow, the dominant coastal habitat of the area, is mostly threatened by boat anchoring. 12 years after the establishment of mooring fields and anchoring restrictions, a study was conducted to measure their effectiveness on the conservation of seagrass and the mitigation of anchoring damage. We found that: (i) the condition of P. oceanica was disturbed, both in the mooring fields and in control locations; (ii) mooring fields and anchoring restrictions did not show to be an efficient system for the protection of seagrass, in fact anchor scars increased after the tourist season; (iii) the mooring systems had an impact on the surrounding area of the meadow, probably due to their misuse. On the basis of these results, management recommendations for marine parks are proposed. PMID:25467874

  1. Functionalized Nanostructures: Redox-Active Porphyrin Anchors for Supramolecular DNA Assemblies

    KAUST Repository

    Börjesson, Karl

    2010-09-28

    We have synthesized and studied a supramolecular system comprising a 39-mer DNA with porphyrin-modified thymidine nucleosides anchored to the surface of large unilamellar vesicles (liposomes). Liposome porphyrin binding characteristics, such as orientation, strength, homogeneity, and binding site size, was determined, suggesting that the porphyrin is well suited as a photophysical and redox-active lipid anchor, in comparison to the inert cholesterol anchor commonly used today. Furthermore, the binding characteristics and hybridization capabilities were studied as a function of anchor size and number of anchoring points, properties that are of importance for our future plans to use the addressability of these redox-active nodes in larger DNA-based nanoconstructs. Electron transfer from photoexcited porphyrin to a lipophilic benzoquinone residing in the lipid membrane was characterized by steady-state and time-resolved fluorescence and verified by femtosecond transient absorption. © 2010 American Chemical Society.

  2. Capillary and anchoring effects in thin hybrid nematic films and connection with bulk behavior.

    Science.gov (United States)

    de las Heras, D; Mederos, Luis; Velasco, Enrique

    2009-01-01

    By means of a molecular model, we examine hybrid nematic films with antagonistic anchoring angles where one of the surfaces is in the strong anchoring regime. If anchoring at the other surface is weak, and in the absence of wetting by the isotropic phase, the anchoring transition may interact with the capillary isotropic-nematic transition. For general anchoring conditions on this surface we confirm the existence of the steplike biaxial phase and the associated transition to the linear constant-tilt-rotation, configuration. The steplike phase is connected with the bulk isotropic phase for increasing film thickness so that the latter transition is to be interpreted as the capillary isotropic-nematic transition in a hybrid film. PMID:19257057

  3. Procedural debiasing of primacy/anchoring effects in clinical-like judgments.

    Science.gov (United States)

    Mumma, G H; Wilson, S B

    1995-11-01

    Primacy (or anchoring) effects in clinical judgment occur when information presented at an early stage unduly influences a judgment compared to the effect of the same information presented at a later stage. Using recent theoretical models of these effects, three debiasing methods were developed and tested for their efficacy. Contrary to some recent failures to find anchoring effects, both single-cue and sequence anchoring manipulations produced medium-size effects on personality trait ratings and generalized to predictions of behavior. A consider-the-opposite procedure that involved cue sorting by diagnosticity debiased single-cue anchoring, but comparable results were obtained by subjects who simply took notes while reviewing each cue prior to judgment. Bias inoculation was marginally successful at reducing single-cue anchoring. Methodological issues as well as suggestions for future research are discussed. PMID:8778134

  4. Vibration Characteristic of Anchoring System of Bolt and Elastic Wave Propagation Law

    Institute of Scientific and Technical Information of China (English)

    WANG Cheng; LI Yi; NING Jian-guo; LIN Hua-chang

    2006-01-01

    Based on one-dimension wave theory, the propagation law of elastic wave along the rock bolt, rock medium and their coupling system are researched, and the attenuation law and propagation mechanism of wave in the anchoring system are obtained. Meanwhile, the studies on end reflection and dynamic response under load are also carried out experimentally, the relationship between anchoring length and excited wave length is obtained when the end reflection of bolt emerges, and it is concluded that under the condition of bolt loaded,as the load increases, the reflection of the upper interface of anchoring segment weakens while the end reflection strengthens relatively, hence the energy attenuation increases. These results provide some important theory basis for measuring the effective anchoring length of bolt, judging the bonding quality of anchoring end and surrounding rock, and estimating the utmost load force of bolt.

  5. Assessment of behavior, design and testing of anchors for fastening to concrete

    International Nuclear Information System (INIS)

    This report presents the evaluation of behavior and the prediction of tensile capacity of anchors that fail concrete, as the design basis for anchorage. Tests of cast-in place headed anchors, domestically manufactured and installed in uncracked, unreinforced concrete were performed to investigate the behavior of single anchors and multiple anchors with the consideration of various embedment lengths and edge distances. The failure mode and the load-deformation response of these anchors are discussed and the concrete failure data then compared with capacities by the two exiting methods : the 45 degree cone method of ACI 349, appendix B and the Concrete Capacity Design (CCD) method. Discrepancies between the test results and these two prediction methods are assessed and also the basic differences in philosophy and the factors contributing to the philosophical differences in these two methods are addressed

  6. International Divider Walls

    NARCIS (Netherlands)

    Kruis, A.; Sneller, A.C.W.(L.)

    2013-01-01

    The subject of this teaching case is the Enterprise Resource Planning (ERP) system implementation at International Divider Walls, the world market leader in design, production, and sales of divider walls. The implementation in one of the divisions of this multinational company had been successful, a

  7. Thin Wall Iron Castings

    Energy Technology Data Exchange (ETDEWEB)

    J.F. Cuttino; D.M. Stefanescu; T.S. Piwonka

    2001-10-31

    Results of an investigation made to develop methods of making iron castings having wall thicknesses as small as 2.5 mm in green sand molds are presented. It was found that thin wall ductile and compacted graphite iron castings can be made and have properties consistent with heavier castings. Green sand molding variables that affect casting dimensions were also identified.

  8. Timber frame walls

    DEFF Research Database (Denmark)

    Hansen, Ernst Jan de Place; Brandt, Erik

    2010-01-01

    A ventilated cavity is usually considered good practice for removing moisture behind the cladding of timber framed walls. Timber frame walls with no cavity are a logical alternative as they are slimmer and less expensive to produce and besides the risk of a two-sided fire behind the cladding is...

  9. The Humming Wall

    DEFF Research Database (Denmark)

    Morrison, Ann Judith; Manresa-Yee, Cristina; Jensen, Brian Walther Skovgaard; Eshraghi, Neda

    2016-01-01

    We observed interactions with The Humming Wall, a vibrotactile and vibroacoustic interactive artifact placed in an urban park. Prior studies have focused on interactivity with primarily vision based systems (or with this system, the interaction between the wall and a wearable vibrotactile vest...

  10. Skyrmions and domain walls

    OpenAIRE

    Piette, B.; Zakrzewski, W. J.

    1997-01-01

    We study the 3+1 dimensional Skyrme model with a mass term different from the usual one. We show that this new model possesses domain walls solutions. We describe how, in the equivalent 2+1 dimensional model, the Skyrmion is absorbed by the wall.

  11. Stone anchors along the coast of Chilika Lake: New light on the maritime activities of Orissa, India

    Digital Repository Service at National Institute of Oceanography (India)

    Tripati, S.; Patnaik, A.P.

    various parts of India. Kanas is the first instance where stone anchors have been found along with hero stones. This communication deals with stone anchors of Kanas and their role in the maritime activities of Chilika Lake region....

  12. Solar Walls in tsbi3

    DEFF Research Database (Denmark)

    Wittchen, Kim Bjarne

    tsbi3 is a user-friendly and flexible computer program, which provides support to the design team in the analysis of the indoor climate and the energy performance of buildings. The solar wall module gives tsbi3 the capability of simulating solar walls and their interaction with the building. This...... version, C, of tsbi3 is capable of simulating five types of solar walls say: mass-walls, Trombe-walls, double Trombe-walls, internally ventilated walls and solar walls for preheating ventilation air. The user's guide gives a description of the capabilities and how to simulate solar walls in tsbi3....

  13. Effect of confining walls on the interaction between particles in a nematic liquid crystal

    International Nuclear Information System (INIS)

    We investigate theoretically how the confining walls of a nematic cell affect the interaction of particles mediated by the elastic deformation of a nematic liquid crystal. We consider the case where strong homeotropic or planar anchoring is imposed on the flat parallel walls so that the director on the wall surfaces is fixed and uniform alignment is achieved in the bulk. This set-up is more realistic experimentally than any other previous theoretical studies concerning the elastic-deformation-mediated interactions that assume an infinite medium. When the anchoring on the particle surfaces is weak, an exact expression of the interaction between two particles can be obtained. The two-body interaction can be regarded as the interaction between one particle and an infinite array of 'mirror images' of the other particle. We also obtain the 'self-energy' of one particle, the interaction of a particle with confining walls, which is interpreted along the same way as the interaction of one particle with its mirror images. We show that the walls play a different role in homeotropic and planar cells, which is attributed to the difference in the symmetry of the cells. We also present the landscapes of the interaction energy when one particle is fixed and demonstrate that the interaction is sensitively dependent on the fixed particle as well as the interparticle distance

  14. Suture locking of isolated internal locking knotless suture anchors is not affected by bone quality

    Directory of Open Access Journals (Sweden)

    Woodmass JM

    2015-06-01

    Full Text Available Jarret M Woodmass,1 Graeme Matthewson,1 Yohei Ono,1,2 Aaron J Bois,1 Richard S Boorman,1 Ian KY Lo,1 Gail M Thornton1,31Department of Surgery, Section of Orthopaedic Surgery, McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, AB, Canada; 2Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan; 3Department of Orthopaedics, University of British Columbia, Vancouver, BC, Canada Purpose: The purpose of this study was to evaluate the mechanical performance of different suture locking mechanisms including: i interference fit between the anchor and the bone (eg, 4.5 mm PushLock, 5.5 mm SwiveLock, ii internal locking mechanism within the anchor itself (eg, 5.5 mm SpeedScrew, or iii a combination of interference fit and internal locking (eg, 4.5 mm MultiFIX P, 5.5 mm MultiFIX S. Methods: Anchors were tested in foam blocks representing normal (20/8 foam or osteopenic (8/8 foam bone, using standard suture loops pulled in-line with the anchor to isolate suture locking. Mechanical testing included cyclic testing for 500 cycles from 10 N to 60 N at 60 mm/min, followed by failure testing at 60 mm/min. Displacement after 500 cycles at 60 N, number of cycles at 3 mm displacement, load at 3 mm displacement, and maximum load were evaluated. Results: Comparing 8/8 foam to 20/8 foam, load at 3 mm displacement and maximum load were significantly decreased (P<0.05 with decreased bone quality for anchors that, even in part, relied on an interference fit suture locking mechanism (ie, 4.5 mm PushLock, 5.5 mm SwiveLock, 4.5 mm MultiFIX P, 5.5 mm MultiFIX S. Bone quality did not affect the mechanical performance of 5.5 mm SpeedScrew anchors which have an isolated internal locking mechanism. Conclusion: The mechanical performance of anchors that relied, even in part, on interference fit were affected by bone quality. Isolated internal locking knotless suture anchors functioned independently of bone quality

  15. Career Anchors and the Effects of Downsizing: Implications for Generations and Cultures at Work. A Preliminary Investigation.

    Science.gov (United States)

    Marshall, Verena; Bonner, Dede

    2003-01-01

    The relationships among career anchors, age, culture, gender, employment experience, and the impact of career planning on downsizing were examined with data from 423 management students (49% had been downsized). Lifestyle was the most valued anchor across age groups, stability/security the least; compared with Schein's earlier anchors research,…

  16. First wall for NET

    International Nuclear Information System (INIS)

    In collaboration with ANSALDO and within the frame of the European Fusion Tecnology Task N1 (Plasma Facing Components Design Studies), ENEA has performed a design an manufacturing feasibility study for the first wall of the Next European Torus (NET) during its ''physics'' operation phase. The main design specifications are average neutron wall load=1 MW/m2, peak surface heat flux=0.4 MW/m2, total number of burn pulses=1*104, average burn pulse duration=100 s, average neutron fluence=0.03 MWy/m2, structure material=AISI 316L SA, coolant=H2O at 50/100 centigrates (in/out). The reference ENEA-ANSALDO design is based on the use of flat plates coupled by microbrazing to poloidal cooling tubes. The technological development work has led to the design and manufacturing of a representative NET first wall box segment (0.65x 0.25x0.15 m) mockup which will be tested in the 190 kW Thermal Fatique Test Facility at JRC-Ispra. In this paper, we report on the various aspects of the basic experimental and theoretical investigations on the plasma-wall interactions for adequate protection of the first wall against erosion, global stress analysis of the first wall box, thecnological tests on brazed joints, and disign and manufacturing of the first wall mockup

  17. Incisionless Pubovaginal Fascial Sling Using Transvaginal Bone Anchors for the Treatment of Stress Urinary Incontinence

    Directory of Open Access Journals (Sweden)

    Sandip P. Vasavada

    2004-01-01

    Full Text Available Introduction: Bladder neck suspension (BNS for stress urinary incontinence (SUI can have significant morbidity, including bleeding, infection and pain. In an effort to reduce this potential morbidity, we have devised a technique which provides the same suburethral support as a standard anterior vaginal wall sling (AVWS, but without a vaginal or suprapubic incision. We describe this minimally invasive technique. Methods: From April 1998 to February 1999, 85 women underwent an incisionless suburethral fascial sling procedure. A transvaginal bone drill was used to place a bone anchor loaded with #1 prolene suture into the inferior aspect of the pubic bone on either side of the urethra. A subepithelial tunnel was created at the level of the bladder neck. A 2 x 7 cm segment of cadaveric fascia lata was placed through the subepithelial tunnel. The sutures were passed through the fascia 5mm from either edge, effectively creating a 6.0 cm sling. Finally, the sutures are tied up to the pubic symphysis.Results: Follow-up was via a self-administered questionnaire and patient interview. Recurrent SUI was noted in 2/85 (3%. New onset urge incontinence was present in 4/85 (5%. Permanent urinary retention has not occurred in either group. All procedures were performed on an outpatient basis and no operative complications occurred.Conclusions: Early results for the incisionless sling compare favorably with the long term results for the AVWS. This minimally invasive approach has thus far not been associated with any significant complications. Elimination of the vaginal and suprapubic incisions has not compromised efficacy, and appears to reduce the incidence of urge incontinence. Long term follow-up will establish the lasting efficacy of this novel surgical technique.

  18. Magnetic domain wall gratings for magnetization reversal tuning and confined dynamic mode localization.

    Science.gov (United States)

    Trützschler, Julia; Sentosun, Kadir; Mozooni, Babak; Mattheis, Roland; McCord, Jeffrey

    2016-01-01

    High density magnetic domain wall gratings are imprinted in ferromagnetic-antiferromagnetic thin films by local ion irradiation by which alternating head-to-tail-to-head-to-tail and head-to-head-to-tail-to-tail spatially overlapping domain wall networks are formed. Unique magnetic domain processes result from the interaction of anchored domain walls. Non-linear magnetization response is introduced by the laterally distributed magnetic anisotropy phases. The locally varying magnetic charge distribution gives rise to localized and guided magnetization spin-wave modes directly constrained by the narrow domain wall cores. The exchange coupled multiphase material structure leads to unprecedented static and locally modified dynamic magnetic material properties. PMID:27487941

  19. 地震动对锚索桩的响应特性研究%Dynamic Response Characteristics of Anchor Cable Piles under Ground Motion

    Institute of Scientific and Technical Information of China (English)

    曲宏略; 胡焕国; 张建经; 朱大鹏

    2015-01-01

    汶川地震震害调查表明使用预应力锚索的桩板墙变形协调性好,抗震性能高,但目前在预应力锚索桩板墙的抗震设计理论研究方面仍比较落后。鉴于此,利用 FLAC3D 对预应力锚索桩板墙的地震响应特征进行研究,包括桩身土压力分布、桩身变位及锚索内锚段应力的动力响应特性等,并通过改变地震动参数进行多种工况的分析,系统研究地震动参数对桩-土-锚动力耦合相互作用规律的影响。研究成果可加强对预应力锚索桩板墙抗震表现的认识,也为深化抗震机理研究提供可靠的依据。%Prestressed anchor sheet pile wall is a light-weight retaining structure.As a new style of retaining structure,the stressed form of a prestressed anchor sheet pile is similar to a beam-style structure.This is deemed to be more reasonable than the stressed form of a cantilever that is usu-ally used for stabilizing piles.In addition,because of advanced deformation compatibility and bet-ter seismic performance,the prestressed anchor sheet pile is widely used in landslide treatment. An investigation of seismic hazards in the Wenchuan earthquake suggests that a stabilizing pile has many advantages in terms of landslide treatment.Because this structure plays an important role in landslide treatment,many researchers have performed analysis on static design and loading characteristics;however,there is limited research on the seismic design theory of prestressed an-chor sheet pile walls.The FLAC3D model was used to study the seismic response of this struc-ture,including the distribution of seismic earth pressure along the pile,deflection of the pile,and dynamic characteristics of cable stress in the anchor.In addition,the analyses of multiple cases were completed using various parameters of ground motion;thus,the influence of the parameters on the dynamic interaction law of pile-soil-anchor was systematically derived.Through FLAC3D and a

  20. Plasma-wall interactions

    International Nuclear Information System (INIS)

    The plasma wall interactions for two extreme cases, the 'vacuum model' and the 'cold gas blanket' are outlined. As a first step for understanding the plasma wall interactions the elementary interaction processes at the first wall are identified. These are energetic ion and neutral particle trapping and release, ion and neutral backscattering, ion sputtering, desorption by ions, photons and electrons and evaporation. These processes have only recently been started to be investigated in the parameter range of interest for fusion research. The few measured data and their extrapolation into regions not yet investigated are reviewed

  1. Actual model test for tensile capacity evaluation of anchor system in NPPs

    International Nuclear Information System (INIS)

    The design of anchor system for fastening the equipments and piping systems, etc. to concrete structure has based on the ACI 349 code in Korean nuclear power plant. But, CCD method of CEB code which was processed in Europe shows that anchor system design according to ACI 349 code has some of overestimated effects in the evaluation of tensile and shear capacity of the anchor system. Furthermore, according to US NRC SRP published in 1996. US NRC recognized that ACI 349 code had some problems for design of anchor system and recommended that anchor system should be designed by test results for each case. In order to identify the validity of both ACI 349 Code and CEB-CCD code for design of anchor system in NPPs. KEPRI is examining a large number of literatures related to this subject and based on the above examination, is carrying out the actual model test considering various test conditions. Among the actual model test, test plan and pretest results related to tensile capacity evaluation of anchor system are shown in this paper

  2. Engineering kinematic theory of the contact earth pressure and its application to the static calculation of thin quay walls

    Directory of Open Access Journals (Sweden)

    V.S. Korovkin

    2013-10-01

    Full Text Available Construction of deep-water thrust berthing structures requires using new and more perfect methods of calculation containing fewer assumptions. A version of the engineering kinematic theory of contact earth pressure in the application to the water-transport and offshore structures was suggested in the article. A dimensionless static “compression – tension” diagram of the soil, presented by curvilinear function, was used in the method. In this case, the displacement of the limit point of the diagram is determined with the account of the plastic deformation modulus in the earth contact point. Practical application of engineering theory was implemented in the proposed method of the mirroring with respect to anchored thin walls. In this method different lateral pressure profiles depending on the rated scheme were used. This method consists in three steps’ loading of anchored wall. The first stage – the normal calculation of the wall in the form of beam loaded by active earth pressure and bearing on the anchor pole and partly on the base ground. The second stage – the anchor reaction and the foundation earth reactive pressure are mirrored in the form of external loads acting on the part of the water area on the beam bearing on the backfill and foundation soil. Third stage – repeating the first external load in the form of the earth pressure profile behind the wall derived in the second calculation step. Suggested calculation as distinct from existing methods, which are using active earth pressure, defines more exactly the strains in retaining wall upward or downward.

  3. Red electroluminescence of ruthenium sensitizer functionalized by sulfonate anchoring groups.

    Science.gov (United States)

    Shahroosvand, Hashem; Abbasi, Parisa; Mohajerani, Ezeddin; Janghouri, Mohammad

    2014-06-28

    We have synthesized five novel Ru(ii) phenanthroline complexes with an additional aryl sulfonate ligating substituent at the 5-position [Ru(L)(bpy)2](BF4)2 (1), [Ru(L)(bpy)(SCN)2] (2), [Ru(L)3](BF4)2 (3), [Ru(L)2(bpy)](BF4)2 (4) and [Ru(L)(BPhen)(SCN)2] (5) (where L = 6-one-[1,10]phenanthroline-5-ylamino)-3-hydroxynaphthalene 1-sulfonic, bpy = 2,2'-bipyridine, BPhen = 4,7-diphenyl-1,10-phenanthroline), as both photosensitizers for oxide semiconductor solar cells (DSSCs) and light emitting diodes (LEDs). The absorption and emission maxima of these complexes red shifted upon extending the conjugation of the phenanthroline ligand. Ru phenanthroline complexes exhibit broad metal to ligand charge transfer-centered electroluminescence (EL) with a maximum near 580 nm. Our results indicated that a particular structure (2) can be considered as both DSSC and OLED devices. The efficiency of the LED performance can be tuned by using a range of ligands. Device (2) has a luminance of 550 cd m(-2) and maximum efficiency of 0.9 cd A(-1) at 18 V, which are the highest values among the five devices. The turn-on voltage of this device is approximately 5 V. The role of auxiliary ligands in the photophysical properties of Ru complexes was investigated by DFT calculation. We have also studied photovoltaic properties of dye-sensitized nanocrystalline semiconductor solar cells based on Ru phenanthroline complexes and an iodine redox electrolyte. A solar energy to electricity conversion efficiency (η) of 0.67% was obtained for Ru complex (2) under standard AM 1.5 irradiation with a short-circuit photocurrent density (Jsc) of 2.46 mA cm(-2), an open-circuit photovoltage (Voc) of 0.6 V, and a fill factor (ff) of 40%, which are all among the highest values for ruthenium sulfonated anchoring groups reported so far. Monochromatic incident photon to current conversion efficiency was 23% at 475 nm. Photovoltaic studies clearly indicated dyes with two SCN substituents yielded a higher Jsc for the

  4. Wireless and acoustic hearing with bone-anchored hearing devices

    Science.gov (United States)

    Bosman, Arjan J.; Mylanus, Emmanuel A.M.; Hol, Myrthe K.S.; Snik, Ad F.M.

    2016-01-01

    Abstract Objective: The efficacy of wireless connectivity in bone-anchored hearing was studied by comparing the wireless and acoustic performance of the Ponto Plus sound processor from Oticon Medical relative to the acoustic performance of its predecessor, the Ponto Pro. Study sample: Nineteen subjects with more than two years' experience with a bone-anchored hearing device were included. Thirteen subjects were fitted unilaterally and six bilaterally. Design: Subjects served as their own control. First, subjects were tested with the Ponto Pro processor. After a four-week acclimatization period performance the Ponto Plus processor was measured. In the laboratory wireless and acoustic input levels were made equal. In daily life equal settings of wireless and acoustic input were used when watching TV, however when using the telephone the acoustic input was reduced by 9 dB relative to the wireless input. Results: Speech scores for microphone with Ponto Pro and for both input modes of the Ponto Plus processor were essentially equal when equal input levels of wireless and microphone inputs were used. Only the TV-condition showed a statistically significant (p <5%) lower speech reception threshold for wireless relative to microphone input. In real life, evaluation of speech quality, speech intelligibility in quiet and noise, and annoyance by ambient noise, when using landline phone, mobile telephone, and watching TV showed a clear preference (p <1%) for the Ponto Plus system with streamer over the microphone input. Due to the small number of respondents with landline phone (N = 7) the result for noise annoyance was only significant at the 5% level. Conclusion: Equal input levels for acoustic and wireless inputs results in equal speech scores, showing a (near) equivalence for acoustic and wireless sound transmission with Ponto Pro and Ponto Plus. The default 9-dB difference between microphone and wireless input when using the telephone results in a substantial

  5. Extrusion of bone anchor suture following flexor digitorum profundus tendon avulsion injury repair.

    LENUS (Irish Health Repository)

    Tiong, William H C

    2011-09-01

    Flexor digitorum profundus (FDP) zone I tendon avulsion injury is traditionally repaired with a pullout suture technique. More recently, bone anchor sutures have been used as a viable alternative and have largely replaced areas in hand surgery where pullout suture technique was once required. To date, there have been very few complications reported related to bone anchor suture use in FDP tendon reattachment to the bone. We report a very unusual case of extrusion of bone anchor through the nailbed, 6 years after zone I FDP tendon avulsion injury repair and a brief review of literature.

  6. Rock engineering design of post-tensioned anchors for dams – A review

    OpenAIRE

    Brown, E.T.

    2015-01-01

    High-capacity, post-tensioned anchors have found wide-spread use, originally in initial dam design and construction, and more recently in the strengthening and rehabilitation of concrete dams to meet modern design and safety standards. Despite the advances that have been made in rock mechanics and rock engineering during the last 80 years in which post-tensioned anchors have been used in dam engineering, some aspects of the rock engineering design of high-capacity rock anchors for dams have c...

  7. Behavior of pre-stress group anchors--Theory approach and model

    Institute of Scientific and Technical Information of China (English)

    HE Siming; WANG Chenghua; QIAO Jianping

    2003-01-01

    First of all the pre-stress group anchor ropes are resolved into two sub-systems: the stable rock stand lateral resistance load and inner bonding section stand lateral resistance load and pre-stress load. Then, discretization of every sub-system was carried on and it is assumed that different micro-sections possess uniform distribution side resistance. On the basis of Mindlin stress solution, stress overlay principle, modified layered-summation method as well as the load transfer method, we study the anchor group effect and present a theory model which calculates the anchor group effect and establishes the relevant iterate standard.

  8. Pull-out behavior of CFRP single-strap ground anchors

    OpenAIRE

    Fan, Haifeng; Keller, Thomas; Vassilopoulos, Anastasios

    2016-01-01

    Pull-out experiments were performed on four carbon fiber-reinforced polymer (CFRP) ground anchors simulating their applications in rock and soil. The CFRP tendons used in these anchors comprise a single-strap end on both the ground and air sides. On the ground side, the single-strap end is embedded in a cylinder of high-strength grout which fits into the borehole. In rock applications, the ground-side anchor can be used directly without additional confinement, while in the case of soil, an ad...

  9. Automatic Wall Painting Robot

    OpenAIRE

    P.KEERTHANAA, K.JEEVITHA, V.NAVINA, G.INDIRA, S.JAYAMANI

    2013-01-01

    The Primary Aim Of The Project Is To Design, Develop And Implement Automatic Wall Painting Robot Which Helps To Achieve Low Cost Painting Equipment. Despite The Advances In Robotics And Its Wide Spreading Applications, Interior Wall Painting Has Shared Little In Research Activities. The Painting Chemicals Can Cause Hazards To The Human Painters Such As Eye And Respiratory System Problems. Also The Nature Of Painting Procedure That Requires Repeated Work And Hand Rising Makes It Boring, Time A...

  10. Plasma-wall interaction

    International Nuclear Information System (INIS)

    This document gathers the 43 slides presented in the framework of the week long lecture 'hot plasmas 2004' and dedicated to plasma-wall interaction in a tokamak. This document is divided into 4 parts: 1) thermal load on the wall, power extraction and particle recovery, 2) basic edge plasma physics, 3) processes that drive the plasma-solid interaction, and 4) material conditioning (surface treatment...) for ITER

  11. Conducting Wall Hall Thrusters

    Science.gov (United States)

    Goebel, Dan M.; Hofer, Richard R.; Mikellides, Ioannis G.; Katz, Ira; Polk, James E.; Dotson, Brandon

    2013-01-01

    A unique configuration of the magnetic field near the wall of Hall thrusters, called Magnetic Shielding, has recently demonstrated the ability to significantly reduce the erosion of the boron nitride (BN) walls and extend the life of Hall thrusters by orders of magnitude. The ability of magnetic shielding to minimize interactions between the plasma and the discharge chamber walls has for the first time enabled the replacement of insulating walls with conducting materials without loss in thruster performance. The boron nitride rings in the 6 kW H6 Hall thruster were replaced with graphite that self-biased to near the anode potential. The thruster efficiency remained over 60% (within two percent of the baseline BN configuration) with a small decrease in thrust and increase in Isp typical of magnetically shielded Hall thrusters. The graphite wall temperatures decreased significantly compared to both shielded and unshielded BN configurations, leading to the potential for higher power operation. Eliminating ceramic walls makes it simpler and less expensive to fabricate a thruster to survive launch loads, and the graphite discharge chamber radiates more efficiently which increases the power capability of the thruster compared to conventional Hall thruster designs.

  12. Peptide Anchor for Folate-Targeted Liposomal Delivery.

    Science.gov (United States)

    Nogueira, Eugénia; Mangialavori, Irene C; Loureiro, Ana; Azoia, Nuno G; Sárria, Marisa P; Nogueira, Patrícia; Freitas, Jaime; Härmark, Johan; Shimanovich, Ulyana; Rollett, Alexandra; Lacroix, Ghislaine; Bernardes, Gonçalo J L; Guebitz, Georg; Hebert, Hans; Moreira, Alexandra; Carmo, Alexandre M; Rossi, Juan Pablo F C; Gomes, Andreia C; Preto, Ana; Cavaco-Paulo, Artur

    2015-09-14

    Specific folate receptors are abundantly overexpressed in chronically activated macrophages and in most cancer cells. Directed folate receptor targeting using liposomes is usually achieved using folate linked to a phospholipid or cholesterol anchor. This link is formed using a large spacer like polyethylene glycol. Here, we report an innovative strategy for targeted liposome delivery that uses a hydrophobic fragment of surfactant protein D linked to folate. Our proposed spacer is a small 4 amino acid residue linker. The peptide conjugate inserts deeply into the lipid bilayer without affecting liposomal integrity, with high stability and specificity. To compare the drug delivery potential of both liposomal targeting systems, we encapsulated the nuclear dye Hoechst 34580. The eventual increase in blue fluorescence would only be detectable upon liposome disruption, leading to specific binding of this dye to DNA. Our delivery system was proven to be more efficient (2-fold) in Caco-2 cells than classic systems where the folate moiety is linked to liposomes by polyethylene glycol. PMID:26241560

  13. Econophysical anchoring of unimodal power-law distributions

    International Nuclear Information System (INIS)

    The sciences are abundant with size distributions whose densities have a unimodal shape and power-law tails both at zero and at infinity. The quintessential examples of such unimodal and power-law (UPL) distributions are the sizes of income and wealth in human societies. While the tails of UPL distributions are precisely quantified by their corresponding power-law exponents, their bulks are only qualitatively characterized as unimodal. Consequently, different statistical models of UPL distributions exist, the most popular considering lognormal bulks. In this paper we present a general econophysical framework for UPL distributions termed ‘the anchoring method’. This method: (i) universally approximates UPL distributions via three ‘anchors’ set at zero, at infinity, and at an intermediate point between zero and infinity (e.g. the mode); (ii) is highly versatile and broadly applicable; (iii) encompasses the existing statistical models of UPL distributions as special cases; (iv) facilitates the introduction of new statistical models of UPL distributions and (v) yields a socioeconophysical analysis of UPL distributions. (paper)

  14. High performance supercapacitors using metal oxide anchored graphene nanosheet electrodes

    KAUST Repository

    Baby, Rakhi Raghavan

    2011-01-01

    Metal oxide nanoparticles were chemically anchored onto graphene nanosheets (GNs) and the resultant composites - SnO2/GNs, MnO2/GNs and RuO2/GNs (58% of GNs loading) - coated over conductive carbon fabric substrates were successfully used as supercapacitor electrodes. The results showed that the incorporation of metal oxide nanoparticles improved the capacitive performance of GNs due to a combination of the effect of spacers and redox reactions. The specific capacitance values (with respect to the composite mass) obtained for SnO2/GNs (195 F g-1) and RuO 2/GNs (365 F g-1) composites at a scan rate of 20 mV s-1 in the present study are the best ones reported to date for a two electrode configuration. The resultant supercapacitors also exhibited high values for maximum energy (27.6, 33.1 and 50.6 W h kg-1) and power densities (15.9, 20.4 and 31.2 kW kg-1) for SnO2/GNs, MnO2/GNs and RuO2/GNs respectively. These findings demonstrate the importance and great potential of metal oxide/GNs based composite coated carbon fabric in the development of high-performance energy-storage systems. © 2011 The Royal Society of Chemistry.

  15. Comparison of the Tendon Damage Caused by Four Different Anchor Systems Used in Transtendon Rotator Cuff Repair

    Directory of Open Access Journals (Sweden)

    Qing-Song Zhang

    2012-01-01

    Full Text Available Objectives. The objective of this study was to compare the damage to the rotator cuff tendons caused by four different anchor systems. Methods. 20 cadaveric human shoulder joints were used for transtendon insertion of four anchor systems. The Healix Peek, Fastin RC, Bio-Corkscrew Suture, and Healix Transtend anchors were inserted through the tendons using standard transtendon procedures. The areas of tendon damage were measured. Results. The areas of tendon damage (mean ± standard deviation, n=7 were 29.1 ± 4.3 mm2 for the Healix Peek anchor, 20.4 ± 2.3 mm2 for the Fastin RC anchor, 23.4 ± 1.2 mm2 for the Bio-Corkscrew Suture anchor, 13.7 ± 3.2 mm2 for the Healix Transtend anchor inserted directly, and 9.1 ± 2.1 mm2 for the Healix Transtend anchor inserted through the Percannula system (P<0.001 or P<0.001, compared to other anchors. Conclusions. In a cadaver transtendon rotator cuff repair model, smaller anchors caused less damage to the tendon tissues. The Healix Transtend implant system caused the least damage to the tendon tissues. Our findings suggest that smaller anchors should be considered when performing transtendon procedures to repair partial rotator cuff tears.

  16. Simulation of the Load Evolution of an Anchoring System under a Blasting Impulse Load Using FLAC3D

    Directory of Open Access Journals (Sweden)

    Xigui Zheng

    2015-01-01

    Full Text Available A limitation in research on bolt anchoring is the unknown relationship between dynamic perturbation and mechanical characteristics. This paper divides dynamic impulse loads into engineering loads and blasting loads and then employs numerical calculation software FLAC3D to analyze the stability of an anchoring system perturbed by an impulse load. The evolution of the dynamic response of the axial force/shear stress in the anchoring system is thus obtained. It is revealed that the corners and middle of the anchoring system are strongly affected by the dynamic load, and the dynamic response of shear stress is distinctly stronger than that of the axial force in the anchoring system. Additionally, the perturbation of the impulse load reduces stress in the anchored rock mass and induces repeated tension and loosening of the rods in the anchoring system, thus reducing the stability of the anchoring system. The oscillation amplitude of the axial force in the anchored segment is mitigated far more than that in the free segment, demonstrating that extended/full-length anchoring is extremely stable and surpasses simple anchors with free ends.

  17. Two novel, putatively cell wall-associated and glycosylphosphatidylinositol-anchored alpha-glucanotransferase enzymes of aspergillus niger

    NARCIS (Netherlands)

    van der Kaaij, R. A.; Yuan, X.-L.; Franken, A.; Ram, A. F. J.; Punt, P. J.; Dijkhuizen, L.; Maarel, M.J.E.C. van der

    2007-01-01

    In the genome sequence of Aspergillus niger CBS 513.88, three genes were identified with high similarity to fungal alpha-amylases. The protein sequences derived from these genes were different in two ways from all described fungal alpha-amylases: they were predicted to be glycosylphosphatidyllinosit

  18. Structural and Functional Analysis of Cell Wall-anchored Polypeptide Adhesin BspA in Streptococcus agalactiae.

    Science.gov (United States)

    Rego, Sara; Heal, Timothy J; Pidwill, Grace R; Till, Marisa; Robson, Alice; Lamont, Richard J; Sessions, Richard B; Jenkinson, Howard F; Race, Paul R; Nobbs, Angela H

    2016-07-29

    Streptococcus agalactiae (group B Streptococcus, GBS) is the predominant cause of early-onset infectious disease in neonates and is responsible for life-threatening infections in elderly and immunocompromised individuals. Clinical manifestations of GBS infection include sepsis, pneumonia, and meningitis. Here, we describe BspA, a deviant antigen I/II family polypeptide that confers adhesive properties linked to pathogenesis in GBS. Heterologous expression of BspA on the surface of the non-adherent bacterium Lactococcus lactis confers adherence to scavenger receptor gp340, human vaginal epithelium, and to the fungus Candida albicans Complementary crystallographic and biophysical characterization of BspA reveal a novel β-sandwich adhesion domain and unique asparagine-dependent super-helical stalk. Collectively, these findings establish a new bacterial adhesin structure that has in effect been hijacked by a pathogenic Streptococcus species to provide competitive advantage in human mucosal infections. PMID:27311712

  19. Mechanical Analysis of Stress Distribution in a Carbon Fiber-Reinforced Polymer Rod Bonding Anchor

    Directory of Open Access Journals (Sweden)

    Peng Feng

    2014-04-01

    Full Text Available This paper presents an elastic shear stress distribution theoretical model at the carbon fiber-reinforced polymer (CFRP-adhesive interface of a single-rod and a multi-rod straight-pipe bonding anchor. A comparison between theoretical and finite element analysis results reveals that the accuracy of the theory can be used to guide the preliminary design of CFRP rod bonding anchors. The mechanical performance of the inner cone bonding anchor for multi-rods are evaluated within different coefficients of friction and inner inclined angles. Numerical results indicate that the straight-parabolic inner cone bonding anchor has a significant effect on reducing the shear force at the loading end.

  20. Suture slippage in knotless suture anchors resulting in subacromial-subdeltoid bursitis.

    Science.gov (United States)

    Hayeri, Mohammad Reza; Keefe, Daniel T; Chang, Eric Y

    2016-05-01

    Rotator cuff repair using a suture bridge and knotless suture anchors is a relatively new, but increasingly used technique. The suture bridge technique creates an anatomically similar and more secure rotator cuff repair compared with conventional arthroscopic techniques and the use of knotless anchors eliminates the challenges associated with knot tying during arthroscopic surgery. However, previous in vitro biomechanical tests have shown that the hold of the suture in a knotless suture anchor is far lower than the pullout strength of the anchor from bone. Up until now slippage has been a theoretical concern. We present a prospectively diagnosed case of in vivo suture loosening after rotator cuff repair using a knotless bridge technique resulting in subacromial-subdeltoid bursitis. PMID:26739301

  1. Wind wave spectra gathered by anchored data buoys (NODC Accession 9900175)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Wind wave spectra data were collected using anchored data buoys in various place such as Coastal Waters of Western US, Gulf of Mexico, South Pacific Ocean, Great...

  2. Stone anchors from Bet Dwarka Island, Gujarat, Coast, India: Significance to historical period maritime activities

    Digital Repository Service at National Institute of Oceanography (India)

    Sundaresh; Gaur, A.S.; Tripati, S.; Gudigar, P.; Bandodkar, S.N.

    Bet Dwarka Island is situated on the extreme west of Indian territory in Jamnagar district of Gujarat. Underwater, the most preserved remains of ancient maritime activity could be the stone anchors of different types, as every boat requires...

  3. Anchored Neighborhood Regression for Fast Example-Based Super-Resolution

    OpenAIRE

    Timofte, Radu; De Smet, Vincent; Van Gool, Luc

    2013-01-01

    Timofte R., De Smet V., Van Gool L., ''Anchored neighborhood regression for fast example-based super-resolution'', Proceedings 14th international conference on computer vision - ICCV 2013, pp. 1920-1927, December 3-6, 2013, Sydney, Australia.

  4. Tri-layer wrinkling as a mechanism for anchoring center initiation in the developing cerebellum.

    Science.gov (United States)

    Lejeune, Emma; Javili, Ali; Weickenmeier, Johannes; Kuhl, Ellen; Linder, Christian

    2016-07-01

    During cerebellar development, anchoring centers form at the base of each fissure and remain fixed in place while the rest of the cerebellum grows outward. Cerebellar foliation has been extensively studied; yet, the mechanisms that control anchoring center initiation and position remain insufficiently understood. Here we show that a tri-layer model can predict surface wrinkling as a potential mechanism to explain anchoring center initiation and position. Motivated by the cerebellar microstructure, we model the developing cerebellum as a tri-layer system with an external molecular layer and an internal granular layer of similar stiffness and a significantly softer intermediate Purkinje cell layer. Including a weak intermediate layer proves key to predicting surface morphogenesis, even at low stiffness contrasts between the top and bottom layers. The proposed tri-layer model provides insight into the hierarchical formation of anchoring centers and establishes an essential missing link between gene expression and evolution of shape. PMID:27252048

  5. Comparison of two bone anchored hearing instruments: BP100 and Ponto Pro

    DEFF Research Database (Denmark)

    Olsen, Steen Østergaard; Glad, Henrik; Nielsen, Lars Holme

    2011-01-01

    This study aimed at investigating if there were differences in auditory performance, operation, or user preference between the Ponto Pro or the BP100, two bone anchored hearing instruments (BAHI) with modern sound processing technology....

  6. The Chlamydomonas cell wall: characterization of the wall framework

    OpenAIRE

    1985-01-01

    The cell wall of the biflagellate alga Chlamydomonas reinhardtii is a multilayered, extracellular matrix composed of carbohydrates and 20-25 polypeptides. To learn more about the forces responsible for the integrity of this cellulose-deficient cell wall, we have begun studies to identify and characterize the framework of the wall and to determine the effects of the cell wall-degrading enzyme, lysin, on framework structure and protein composition. In these studies we used walls released into t...

  7. Dynamic behaviour of anchors in cracked and uncracked concrete: a progress report

    International Nuclear Information System (INIS)

    In early 1993, the US Nuclear Regulatory Commission began a research program at The University of Texas at Austin, dealing with the dynamic behavior of anchors in cracked and uncracked concrete. In this paper, the progress of that research program is reviewed. The test program is summarized, and work performed to date is reviewed, with emphasis on the dynamic and static behavior of single tensile anchors in uncracked concrete. General conclusions from that work are discussed, and future plans are presented. (orig.)

  8. Dynamic behavior of anchors in cracked and uncracked concrete: A progress report

    International Nuclear Information System (INIS)

    In early 1993, the US Nuclear Regulatory Commission began a research program at The University of Texas at Austin, dealing with the dynamic behavior of anchors in cracked and uncracked concrete. In this paper, the progress of that research program is reviewed. The test program is summarized, the work performed to date is reviewed, with emphasis on the dynamic and static behavior of single tensile anchors in uncracked concrete. General conclusions from that work are discussed, and future plans are presented

  9. Dynamic behaviour of anchors in cracked and uncracked concrete: a progress report

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez, M. [Texas Univ., Austin, TX (United States). Dept. of Civil Engineering; Zhang Yonggang [Texas Univ., Austin, TX (United States). Dept. of Civil Engineering; Lotez, D. [Texas Univ., Austin, TX (United States). Dept. of Civil Engineering; Graves, H.L. III [US Nuclear Regulatory Commission, Washington, DC (United States); Klingner, R.E. [Texas Univ., Austin, TX (United States). Dept. of Civil Engineering

    1997-05-01

    In early 1993, the US Nuclear Regulatory Commission began a research program at The University of Texas at Austin, dealing with the dynamic behavior of anchors in cracked and uncracked concrete. In this paper, the progress of that research program is reviewed. The test program is summarized, and work performed to date is reviewed, with emphasis on the dynamic and static behavior of single tensile anchors in uncracked concrete. General conclusions from that work are discussed, and future plans are presented. (orig.)

  10. Psychological career resources as predictors of working adults’ career anchors: An exploratory study

    OpenAIRE

    Melinde Coetzee; Dries Schreuder

    2009-01-01

    This study explored the relationship between the psychological career resources and career anchors of a sample of 2 997 working adults at predominantly managerial and supervisory levels in the service industry. The Psychological Career Resources Inventory and the Career Orientations Inventory were applied. Stepwise regression analyses indicated dimensions of psychological career resources as significant predictors of  participants’ career anchors. The findings add valuable new knowledge that ...

  11. GPI-anchored proteins do not reside in ordered domains in the live cell plasma membrane

    OpenAIRE

    Sevcsik, Eva; Brameshuber, Mario; Fölser, Martin; Weghuber, Julian; Honigmann, Alf; Schütz, Gerhard J.

    2015-01-01

    The organization of proteins and lipids in the plasma membrane has been subject of a long-lasting debate. Membrane rafts of higher lipid chain order were proposed to mediate protein interactions, but have thus far not been directly observed. Here, we use protein micropatterning combined with single-molecule tracking to put current models to the test: we rearranged lipid-anchored raft proteins (glycosylphosphatidylinositol(GPI)-anchored mGFP) directly in the live cell plasma membrane and measu...

  12. GPI-anchored proteins do not reside in ordered domains in the live cell plasma membrane.

    OpenAIRE

    Sevcsik, E.; Brameshuber, M.; Fölser, M.; Weghuber, J.; Honigmann, A.; Schütz, G

    2015-01-01

    The organization of proteins and lipids in the plasma membrane has been the subject of a long-lasting debate. Membrane rafts of higher lipid chain order were proposed to mediate protein interactions, but have thus far not been directly observed. Here we use protein micropatterning combined with single-molecule tracking to put current models to the test: we rearranged lipid-anchored raft proteins (glycosylphosphatidylinositol(GPI)-anchored-mGFP) directly in the live cell plasma membrane and me...

  13. Uplift of Symmetrical Anchor Plates by Using Grid-Fixed Reinforced Reinforcement in Cohesionless Soil

    Institute of Scientific and Technical Information of China (English)

    Hamed Niroumand; Khairul Anuar Kassim

    2014-01-01

    Uplift response of symmetrical anchor plates with and without grid fixed reinforced (GFR) reinforcement was evaluated in model tests and numerical simulations by Plaxis. Many variations of reinforcement layers were used to reinforce the sandy soil over symmetrical anchor plates. In the current research, different factors such as relative density of sand, embedment ratios, and various GFR parameters including size, number of layers, and the proximity of the layer to the symmetrical anchor plate were investigated in a scale model. The failure mechanism and the associated rupture surface were observed and evaluated. GFR, a tied up system made of fiber reinforcement polymer (FRP) strips and end balls, was connected to the geosynthetic material and anchored into the soil. Test results showed that using GFR reinforcement significantly improved the uplift capacity of anchor plates. It was found that the inclusion of one layer of GFR, which rested directly on the top of the anchor plate, was more effective in enhancing the anchor capacity itself than other methods. It was found that by including GFR the uplift response was improved by 29%. Multi layers of GFR proved more effective in enhancing the uplift capacity than a single GFR reinforcement. This is due to the additional anchorage provided by the GFR at each level of reinforcement. In general, the results show that the uplift capacity of symmetrical anchor plates in loose and dense sand can be significantly increased by the inclusion of GFR. It was also observed that the inclusion of GFR reduced the requirement for a large L/D ratio to achieve the required uplift capacity. The laboratory and numerical analysis results are found to be in agreement in terms of breakout factor and failure mechanism pattern.

  14. Application Research on Nondestructive Testing Technology for Quality of Anchor Based on Elastic Wave Reflection Method

    Science.gov (United States)

    Xiao, G.; Zhou, L.

    2014-12-01

    Anchor technology has been widely used to reinforce slopes, underground caverns, deep excavations and the foundation of dams. It has attracted more and more attention of research worldwide on how to find a comfortable method to test the quality of anchoring systems. According to the characteristics of anchor systems, we set up the kinetic equations and mathematical models, then solved the models using ANSYS / LS-DYNA program. We found that the simulated mathematical models perfectly match the experimental data. By changing one of the parameters or the input conditions in the model, we were able to understand the characteristic response of excitation energy, excitation length, structural defects, rock quality, and different data acquisition methods. For short anchor systems (grouting density. The obtained values were consistent with the actual experimental data. We also demonstrated that the kinetic energy of the collected waves from the bottom of the anchor had very close relationship with the grouting density and the position of the structural defects. For long anchors (> 60 m), mostly cable anchors, since little research could be followed, we started our research from designing the instrument, writing the program for data acquisition and analysis. We designed and developed novel sensors and preamplifiers. We used vertical stack technology to effectively enhance the weak signals from the deeper interfaces. In data processing, in addition to the traditional filter method, we also explored the current technology of signal processing such as true amplitude recovery and deconvolution, which enabled us to obtain improved signal to noise ratio and sensing precision. Through the above mentioned systematical studies, we developed a reliable nondestructive test method for both short and long anchors based on elastic wave reflection. This research is funded by National Natural Science Foundation of China (Grant No. 41202223)

  15. Dynamic behavior of anchors in cracked and uncracked concrete: A progress report

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez, M.; Yong-gang Zhang; Lotze, D. [Univ. of Texas, Austin, TX (United States)] [and others

    1995-04-01

    In early 1993, the US Nuclear Regulatory Commission began a research program at The University of Texas at Austin, dealing with the dynamic behavior of anchors in cracked and uncracked concrete. In this paper, the progress of that research program is reviewed. The test program is summarized, the work performed to date is reviewed, with emphasis on the dynamic and static behavior of single tensile anchors in uncracked concrete. General conclusions from that work are discussed, and future plans are presented.

  16. The outcome study of arthroscopic repair with anchor suture for anterior shoulder instabilities

    OpenAIRE

    Guity MR; Sianati S

    2010-01-01

    "nBackground: Anterior glenohumeral instabilities can be corrected with open and arthroscopic surgery. The purpose of this study was to evaluate retrospectively the surgical outcomes of arthroscopic repair of anterior glenohumeral instabilities with use of suture anchors in a series of patients who were followed for twenty to fifty months."n "nMethods: The results of arthroscopic Bankart repair with use of suture anchors in 30 patients with traumatic recurrent anterior instabil...

  17. A Bayesian Examination of Anchoring Bias and Cheap Talks in Constructed Markets

    OpenAIRE

    Aadland, David; Caplan, Arthur J.

    2005-01-01

    We present a theoretical framework for understanding the relationship between anchoring bias, hypothetical bias, and cheap talk in constructed markets. In our theory, interviewers provide agents with signals such as cheap talk and bid values while eliciting the value for nonmarket goods. In response to these signals, agents revise their prior distributions over the value of the good. Previous empirical studies have failed to account for the interaction between cheap talk and anchoring during ...

  18. Cholesterol-dependent retention of GPI-anchored proteins in endosomes.

    OpenAIRE

    Mayor, S; Sabharanjak, S; Maxfield, F R

    1998-01-01

    Several cell surface eukaryotic proteins have a glycosylphosphatidylinositol (GPI) modification at the Cterminal end that serves as their sole means of membrane anchoring. Using fluorescently labeled ligands and digital fluorescence microscopy, we show that contrary to the potocytosis model, GPI-anchored proteins are internalized into endosomes that contain markers for both receptor-mediated uptake (e.g. transferrin) and fluid phase endocytosis (e.g. dextrans). This was confirmed by immunogol...

  19. DEX-1 and DYF-7 establish sensory dendrite length by anchoring dendritic tips during cell migration

    OpenAIRE

    Heiman, Maxwell G.; Shaham, Shai

    2009-01-01

    Cells are devices whose structures delimit function. For example, in the nervous system, neuronal and glial shapes dictate paths of information flow. To understand how cells acquire their shapes, we examined the formation of a sense organ in C. elegans. Using time-lapse imaging, we found that sensory dendrites form by stationary anchoring of dendritic tips during cell-body migration. A genetic screen identified DEX-1 and DYF-7, extracellular proteins required for dendritic tip anchoring, whic...

  20. Flapping states of an el astically anchored wing in a uniform flow

    OpenAIRE

    Orchini, A.; Mazzino, A; Guerrero, J.; Festa, R.; Boragno, C.

    2012-01-01

    Linear stability analysis of an elastically anchored wing in a uniform flow is investigated both analytically and numerically. The analytical formulation explicitly takes into account the effect of the wake on the wing by means of Theodorsen's theory. Three different parameters non-trivially rule the observed dynamics: mass density ratio between wing and fluid, spring elastic constant and distance between the wing center of mass and the spring anchor point on the wing. We found relationships ...

  1. Seismic behavior of outrigger truss-wall shear connections using multiple steel angles

    Science.gov (United States)

    Li, Xian; Wang, Wei; Lü, Henglin; Zhang, Guangchang

    2016-06-01

    An experimental investigation on the seismic behavior of a type of outrigger truss-reinforced concrete wall shear connection using multiple steel angles is presented. Six large-scale shear connection models, which involved a portion of reinforced concrete wall and a shear tab welded onto a steel endplate with three steel angles, were constructed and tested under combined actions of cyclic axial load and eccentric shear. The effects of embedment lengths of steel angles, wall boundary elements, types of anchor plates, and thicknesses of endplates were investigated. The test results indicate that properly detailed connections exhibit desirable seismic behavior and fail due to the ductile fracture of steel angles. Wall boundary elements provide beneficial confinement to the concrete surrounding steel angles and thus increase the strength and stiffness of connections. Connections using whole anchor plates are prone to suffer concrete pry-out failure while connections with thin endplates have a relatively low strength and fail due to large inelastic deformations of the endplates. The current design equations proposed by Chinese Standard 04G362 and Code GB50011 significantly underestimate the capacities of the connection models. A revised design method to account for the influence of previously mentioned test parameters was developed.

  2. Bioabsorbable Suture Anchor Migration to the Acromioclavicular Joint: How Far Can These Implants Go?

    Directory of Open Access Journals (Sweden)

    Giovanna Medina

    2014-01-01

    Full Text Available Few complications regarding the use of bioabsorbable suture anchors in the shoulder have been reported. What motivated this case report was the unusual location of the anchor, found in the acromioclavicular joint which, to our knowledge, has never been reported so far. A 53-year old male with previous rotator cuff (RC repair using bioabsorbable suture anchors presented with pain and weakness after 2 years of surgery. A suspicion of retear of the RC led to request of a magnetic resonance image, in which the implant was found located in the acromioclavicular joint. The complications reported with the use of metallic implants around the shoulder led to the development of bioabsorbable anchors. Advantages are their absorption over time, minimizing the risk of migration or interference with revision surgery, less artifacts with magnetic resonance imaging, and tendon-to-bone repair strength similar to metallic anchors. Since the use of bioabsorbable suture anchors is increasing, it is important to know the possible complications associated with these devices.

  3. Design and Application of a Field Sensing System for Ground Anchors in Slopes

    Directory of Open Access Journals (Sweden)

    Hyo Seon Park

    2013-03-01

    Full Text Available In a ground anchor system, cables or tendons connected to a bearing plate are used for stabilization of slopes. Then, the stability of a slope is dependent on maintaining the tension levels in the cables. So far, no research on a strain-based field sensing system for ground anchors has been reported. Therefore, in this study, a practical monitoring system for long-term sensing of tension levels in tendons for anchor-reinforced slopes is proposed. The system for anchor-reinforced slopes is composed of: (1 load cells based on vibrating wire strain gauges (VWSGs, (2 wireless sensor nodes which receive and process the signals from load cells and then transmit the result to a master node through local area communication, (3 master nodes which transmit the data sent from sensor nodes to the server through mobile communication, and (4 a server located at the base station. The system was applied to field sensing of ground anchors in the 62 m-long and 26 m-high slope at the side of the highway. Based on the long-term monitoring, the safety of the anchor-reinforced slope can be secured by the timely applications of re-tensioning processes in tendons.

  4. Mechanical characterization of bone anchors used with a bone-attached, parallel robot for skull surgery.

    Science.gov (United States)

    Kobler, Jan-Philipp; Prielozny, Lenka; Lexow, G Jakob; Rau, Thomas S; Majdani, Omid; Ortmaier, Tobias

    2015-05-01

    Bone-attached robots and microstereotactic frames, intended for deep brain stimulation and minimally invasive cochlear implantation, typically attach to a patient's skull via bone anchors. A rigid and reliable link between such devices and the skull is mandatory in order to fulfill the high accuracy demands of minimally invasive procedures while maintaining patient safety. In this paper, a method is presented to experimentally characterize the mechanical properties of the anchor-bone linkage. A custom-built universal testing machine is used to measure the pullout strength as well as the spring constants of bone anchors seated in four different bone substitutes as well as in human cranial bone. Furthermore, the angles at which forces act on the bone anchors are varied to simulate realistic conditions. Based on the experimental results, a substitute material that has mechanical properties similar to those of cranial bone is identified. The results further reveal that the pullout strength of the investigated anchor design is sufficient with respect to the proposed application. However, both the measured load capacity as well as the spring constants vary depending on the load angles. Based on these findings, an alternative bone anchor design is presented and experimentally validated. Furthermore, the results serve as a basis for stiffness simulation and optimization of bone-attached microstereotactic frames. PMID:25771430

  5. DEX-1 and DYF-7 establish sensory dendrite length by anchoring dendritic tips during cell migration.

    Science.gov (United States)

    Heiman, Maxwell G; Shaham, Shai

    2009-04-17

    Cells are devices whose structures delimit function. For example, in the nervous system, neuronal and glial shapes dictate paths of information flow. To understand how cells acquire their shapes, we examined the formation of a sense organ in C. elegans. Using time-lapse imaging, we found that sensory dendrites form by stationary anchoring of dendritic tips during cell-body migration. A genetic screen identified DEX-1 and DYF-7, extracellular proteins required for dendritic tip anchoring, which act cooperatively at the time and place of anchoring. DEX-1 and DYF-7 contain, respectively, zonadhesin and zona pellucida domains, and DYF-7 self-associates into multimers important for anchoring. Thus, unlike other dendrites, amphid dendritic tips are positioned by DEX-1 and DYF-7 without the need for long-range guidance cues. In sequence and function, DEX-1 and DYF-7 resemble tectorins, which anchor stereocilia in the inner ear, suggesting that a sensory dendrite anchor may have evolved into part of a mechanosensor. PMID:19344940

  6. Pash 2.0: scaleable sequence anchoring for next-generation sequencing technologies.

    Science.gov (United States)

    Coarfa, Cristian; Milosavljevic, Aleksandar

    2008-01-01

    Many applications of next-generation sequencing technologies involve anchoring of a sequence fragment or a tag onto a corresponding position on a reference genome assembly. Positional Hashing method, implemented in the Pash 2.0 program, is specifically designed for the task of high-volume anchoring. In this article we present multi-diagonal gapped kmer collation and other improvements introduced in Pash 2.0 that further improve accuracy and speed of Positional Hashing. The goal of this article is to show that gapped kmer matching with cross-diagonal collation suffices for anchoring across close evolutionary distances and for the purpose of human resequencing. We propose a benchmark for evaluating the performance of anchoring programs that captures key parameters in specific applications, including duplicative structure of genomes of humans and other species. We demonstrate speedups of up to tenfold in large-scale anchoring experiments achieved by PASH 2.0 when compared to BLAT, another similarity search program frequently used for anchoring. PMID:18229679

  7. Axion domain wall baryogenesis

    Energy Technology Data Exchange (ETDEWEB)

    Daido, Ryuji; Kitajima, Naoya [Department of Physics, Tohoku University,Sendai 980-8578 (Japan); Takahashi, Fuminobu [Department of Physics, Tohoku University,Sendai 980-8578 (Japan); Kavli IPMU, TODIAS, University of Tokyo,Kashiwa 277-8583 (Japan)

    2015-07-28

    We propose a new scenario of baryogenesis, in which annihilation of axion domain walls generates a sizable baryon asymmetry. Successful baryogenesis is possible for a wide range of the axion mass and decay constant, m≃10{sup 8}–10{sup 13} GeV and f≃10{sup 13}–10{sup 16} GeV. Baryonic isocurvature perturbations are significantly suppressed in our model, in contrast to various spontaneous baryogenesis scenarios in the slow-roll regime. In particular, the axion domain wall baryogenesis is consistent with high-scale inflation which generates a large tensor-to-scalar ratio within the reach of future CMB B-mode experiments. We also discuss the gravitational waves produced by the domain wall annihilation and its implications for the future gravitational wave experiments.

  8. Double wall underground storage tank

    Energy Technology Data Exchange (ETDEWEB)

    Canaan, E.B. Jr.; Wiegand, J.R.; Bartlow, D.H.

    1993-07-06

    A double wall underground storage tank is described comprising: (a) a cylindrical inner wall, (b) a cylindrical outer wall comprising plastic resin and reinforcement fibers, and (c) a layer of spacer filaments wound around the inner wall, the spacer filaments separating the inner and outer walls, and the spacer filaments being at least partially surrounded by voids to enable liquids to flow along the filaments.

  9. Back Reaction from Walls

    CERN Document Server

    Di Dio, Enea; Durrer, Ruth

    2011-01-01

    We study the distance-redshift relation in a universe filled with 'walls' of pressure-less dust separated by under dense regions. We show that as long as the density contrast of the walls is small, or the diameter of the under dense regions is much smaller than the Hubble scale, the distance-redshift relation remains close to what is obtained in a Friedmann universe. However, when arbitrary density contrasts are allowed, every prescribed distance-redshift relation can be reproduced with such models.

  10. Occupy Wall Street

    DEFF Research Database (Denmark)

    Jensen, Michael J.; Bang, Henrik

    2013-01-01

    This article analyzes the political form of Occupy Wall Street on Twitter. Drawing on evidence contained within the profiles of over 50,000 Twitter users, political identities of participants are characterized using natural language processing. The results find evidence of a traditional oppositio......This article analyzes the political form of Occupy Wall Street on Twitter. Drawing on evidence contained within the profiles of over 50,000 Twitter users, political identities of participants are characterized using natural language processing. The results find evidence of a traditional...

  11. UWB Propagation through Walls

    Directory of Open Access Journals (Sweden)

    M. Hajek

    2006-04-01

    Full Text Available The propagation of ultra wide band (UWB signals through walls is analyzed. For this propagation studies, it is necessary to consider not only propagation at a single frequency but in the whole band. The UWB radar output signal is formed by both transmitter and antenna. The effects of antenna receiving and transmitting responses for various antenna types (such as small and aperture antennas are studied in the frequency as well as time domain. Moreover, UWB radar output signals can be substantially affected due to electromagnetic wave propagation through walls and multipath effects.

  12. Side-wall sampler

    Energy Technology Data Exchange (ETDEWEB)

    Morrison, B.

    1969-11-01

    A side-wall sampler which is capable of taking samples from the walls of test holes to a depth of 1,000 ft or more is described. Samples have been extracted from till, clay, silt, and fine- to coarse-grained sands in drift and nonindurated bedrock from more than 1,000 test holes in S. Saskatchewan. Side-hole sampling is faster and cheaper than conventional sampling methods and is ideally suited for geological investigations. Mineralogical paleonto- locical and radiocarbon analyses have been determined on side-hole cores.

  13. Fly on the Wall

    Science.gov (United States)

    Berry, Dave; Korpan, Cynthia

    2009-01-01

    This paper describes the implementation of a peer observation program at the University of Victoria called the Lecture Club. The observers are not interactive during the class--they are the proverbial flies on the wall. The paper identifies the program as self-developmental, discussing the attributes of this learning-to-teach and peer-sharing…

  14. Endometriosis Abdominal wall

    International Nuclear Information System (INIS)

    Endometriosis of abdominal wall is a rare entity wi ch frequently appears after gynecological surgery. Case history includes three cases of parietal endometriosis wi ch were treated in Maciel Hospital of Montevideo. The report refers to etiological diagnostic aspects and highlights the importance of total resection in order to achieve definitive healing

  15. Anterior vaginal wall repair

    Science.gov (United States)

    ... symptoms will go away. This improvement will often last for years. Alternative Names A/P repair; Vaginal wall repair; Anterior and/ ... writing by ADAM Health Solutions. About MedlinePlus Site Map FAQs Contact ... Institutes of Health Page last updated: 23 August 2016

  16. The Invisible Wall.

    Science.gov (United States)

    Zenger, John H.

    1997-01-01

    The barrier to a company's performance may be a conflict of organizational values and culture with those of the training profession. Elements of this value system that create the invisible wall are egalitarianism, people focus, "guerilla" training tactics, and emphasis on human interaction. (JOW)

  17. Disturbance of the bacterial cell wall specifically interferes with biofilm formation.

    Science.gov (United States)

    Bucher, Tabitha; Oppenheimer-Shaanan, Yaara; Savidor, Alon; Bloom-Ackermann, Zohar; Kolodkin-Gal, Ilana

    2015-12-01

    In nature, bacteria communicate via chemical cues and establish complex communities referred to as biofilms, wherein cells are held together by an extracellular matrix. Much research is focusing on small molecules that manipulate and prevent biofilm assembly by modifying cellular signalling pathways. However, the bacterial cell envelope, presenting the interface between bacterial cells and their surroundings, is largely overlooked. In our study, we identified specific targets within the biosynthesis pathways of the different cell wall components (peptidoglycan, wall teichoic acids and teichuronic acids) hampering biofilm formation and the anchoring of the extracellular matrix with a minimal effect on planktonic growth. In addition, we provide convincing evidence that biofilm hampering by transglycosylation inhibitors and D-Leucine triggers a highly specific response without changing the overall protein levels within the biofilm cells or the overall levels of the extracellular matrix components. The presented results emphasize the central role of the Gram-positive cell wall in biofilm development, resistance and sustainment. PMID:26472159

  18. Investigation on the Effect of Drained Strength when Designing Sheet Pile Walls

    DEFF Research Database (Denmark)

    Iversen, Kirsten Malte; Nielsen, Benjaminn Nordahl; Augustesen, Anders Hust

    the height, anchor force, and the maximum bending moment in the wall can be lowered significantly when the effective cohesion is increased above zero. However, as the cohesion increases, the drop in the moment levels off, which implies that the benefit obtained from investigations increasing the......Long sheet pile walls are constructed in the cities as an integrated part of deep excavations for e.g. parking lots, pumping stations, reservoirs, and cut and cover tunnels. To minimise costs, the strength of the soil needs to be determined in the best possible way. The drained strength of clay...... expressed by c and ϕ is often estimated as c 10% = 10%・cu, and found by estimations based on the soil describtion, respectively. However, due to possible slicken slides and tension cracks, c = 0 is used on the back side of the sheet pile wall. This reduces the strength significantly. A parametric study is...

  19. The Cell Wall Teichuronic Acid Synthetase (TUAS) Is an Enzyme Complex Located in the Cytoplasmic Membrane of Micrococcus luteus

    OpenAIRE

    Anderson, John S.; Alexander, Alice A.; Lingyi Lynn Deng; Sijin Lei

    2010-01-01

    The cell wall teichuronic acid (TUA) of Micrococcus luteus is a long-chain polysaccharide composed of disaccharide repeating units [-4-β-D-ManNAcAp-(1→6)α-D-Glcp−1-]n, which is covalently anchored to the peptidoglycan on the inner cell wall and extended to the outer surface of the cell envelope. An enzyme complex responsible for the TUA chain biosynthesis was purified and characterized. The 440 kDa enzyme complex, named teichuronic acid synthetase (TUAS), is...

  20. Moisture Research - Optimizing Wall Assemblies

    Energy Technology Data Exchange (ETDEWEB)

    Arena, Lois [Consortium for Advanced Residential Buildings (CARB), Norwalk, CT (United States); Mantha, Pallavi [Consortium for Advanced Residential Buildings (CARB), Norwalk, CT (United States)

    2013-05-01

    In this project, the Consortium for Advanced Residential Buildings (CARB) team evaluated several different configurations of wall assemblies to determine the accuracy of moisture modeling and make recommendations to ensure durable, efficient assemblies. WUFI and THERM were used to model the hygrothermal and heat transfer characteristics of these walls. Wall assemblies evaluated included code minimum walls using spray foam insulation and fiberglass batts, high R-value walls at least 12 in. thick (R-40 and R-60 assemblies), and brick walls with interior insulation.

  1. Thoracic meningocele in lumbo-costo-vertebral syndrome in a child: possible enlargement with repeated motion by anchoring to the diaphragm.

    Science.gov (United States)

    Wataya, Takafumi; Horikawa, Kyohei; Kitagawa, Masashi; Tashiro, Yuzuru

    2016-08-01

    Lumbo-costo-vertebral syndrome (LCVS) is a rare disorder in children that is characterized by hemivertebrae, congenital absence of ribs, meningocele, and hypoplasia of the truncal and abdominal wall presenting as a congenital lumbar hernia. An otherwise healthy 12-month-old girl was referred to the authors' hospital with soft swelling on her left middle back; scoliosis had been present since birth. Imaging revealed a thoracic meningocele, ectopia of the spleen suggesting lumbar hernia, multiple anomalies of the thoracic vertebral columns, and defects of the ribs; thus, LCVS was diagnosed. Surgical observation revealed that the meningocele was firmly anchored to part of the diaphragm, which created stretching tension in the meningocele continuously with exhalation. Once detached, the meningocele shrank spontaneously and never developed again after cauterization. In this case, continuous or pulsatile pressure in the presence of a vertebral defect was thus considered to be an important factor for formation of the thoracic meningocele. PMID:27058456

  2. Renal Arteriovenous Fistula with Rapid Blood Flow Successfully Treated by Transcatheter Arterial Embolization: Application of Interlocking Detachable Coil as Coil Anchor

    International Nuclear Information System (INIS)

    A 70-year-old woman presented to our outpatient clinic with a large idiopathic renal arteriovenous fistula (AVF). Transcatheter arterial embolization (TAE) using interlocking detachable coils (IDC) as an anchor was planned. However, because of markedly rapid blood flow and excessive coil flexibility, detaching an IDC carried a high risk of migration. Therefore, we first coiled multiple loops of a microcatheter and then loaded it with an IDC. In this way, the coil was well fitted to the arterial wall and could be detached by withdrawing the microcatheter during balloon occlusion ('pre-framing technique'). Complete occlusion of the afferent artery was achieved by additional coiling and absolute ethanol. This technique contributed to a safe embolization of a high-flow AVF, avoiding migration of the IDC

  3. Rising damp in building walls: the wall base ventilation system

    Science.gov (United States)

    Guimarães, A. S.; Delgado, J. M. P. Q.; de Freitas, V. P.

    2012-12-01

    This work intends to validate a new system for treating rising damp in historic buildings walls. The results of laboratory experiments show that an efficient way of treating rising damp is by ventilating the wall base, using the HUMIVENT technique. The analytical model presented describes very well the observed features of rising damp in walls, verified by laboratory tests, who contributed for a simple sizing of the wall base ventilation system that will be implemented in historic buildings.

  4. Comparison of the Tendon Damage Caused by Four Different Anchor Systems Used in Transtendon Rotator Cuff Repair

    OpenAIRE

    Qing-Song Zhang; Sen Liu; Qiuyang Zhang; Yun Xue; Dongxia Ge; Michael J O'Brien; Savoie, Felix H.; Zongbing You

    2012-01-01

    Objectives. The objective of this study was to compare the damage to the rotator cuff tendons caused by four different anchor systems. Methods. 20 cadaveric human shoulder joints were used for transtendon insertion of four anchor systems. The Healix Peek, Fastin RC, Bio-Corkscrew Suture, and Healix Transtend anchors were inserted through the tendons using standard transtendon procedures. The areas of tendon damage were measured. Results. The areas of tendon damage (mean ± standard deviation, ...

  5. Formation of liquid crystal multi-domains with different threshold voltages by varying the surface anchoring energy

    Science.gov (United States)

    Lee, Ji-Hoon; Jin, Huillian; Kim, Jung-Wook; Kim, Ki-Han; Park, Byung Wok; Yoon, Tae-Hoon; Kim, Hoon; Shin, Ki-Chul; Kim, Hee Seop

    2012-09-01

    We propose methods to obtain multi-domains with different threshold voltages for vertically aligned liquid crystal displays without additional transistors or capacitors. We exposed an ultraviolet light through a photomask and spatially varied the surface anchoring energy by partially decomposing the polyimide or inducing the adsorption of reactive monomers. The threshold voltage was reduced with smaller surface anchoring, and the reduction of the threshold could be qualitatively interpreted using a model describing a weak anchoring condition.

  6. Crucial Role for Prion Protein Membrane Anchoring in the Neuroinvasion and Neural Spread of Prion Infection ▿

    OpenAIRE

    Klingeborn, Mikael; Race, Brent; Meade-White, Kimberly D.; Rosenke, Rebecca; Striebel, James F.; Chesebro, Bruce

    2010-01-01

    In nature prion diseases are usually transmitted by extracerebral prion infection, but clinical disease results only after invasion of the central nervous system (CNS). Prion protein (PrP), a host-encoded glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein, is necessary for prion infection and disease. Here, we investigated the role of the anchoring of PrP on prion neuroinvasion by studying various inoculation routes in mice expressing either anchored or anchorless PrP. In contr...

  7. Parameter Sensitivity Analysis on Deformation of Composite Soil-Nailed Wall Using Artificial Neural Networks and Orthogonal Experiment

    Directory of Open Access Journals (Sweden)

    Jianbin Hao

    2014-01-01

    Full Text Available Based on the back-propagation algorithm of artificial neural networks (ANNs, this paper establishes an intelligent model, which is used to predict the maximum lateral displacement of composite soil-nailed wall. Some parameters, such as soil cohesive strength, soil friction angle, prestress of anchor cable, soil-nail spacing, soil-nail diameter, soil-nail length, and other factors, are considered in the model. Combined with the in situ test data of composite soil-nail wall reinforcement engineering, the network is trained and the errors are analyzed. Thus it is demonstrated that the method is applicable and feasible in predicting lateral displacement of excavation retained by composite soil-nailed wall. Extended calculations are conducted by using the well-trained intelligent forecast model. Through application of orthogonal table test theory, 25 sets of tests are designed to analyze the sensitivity of factors affecting the maximum lateral displacement of composite soil-nailing wall. The results show that the sensitivity of factors affecting the maximum lateral displacement of composite soil nailing wall, in a descending order, are prestress of anchor cable, soil friction angle, soil cohesion strength, soil-nail spacing, soil-nail length, and soil-nail diameter. The results can provide important reference for the same reinforcement engineering.

  8. High-R Walls for Remodeling: Wall Cavity Moisture Monitoring

    Energy Technology Data Exchange (ETDEWEB)

    Wiehagen, J.; Kochkin, V.

    2012-12-01

    The focus of the study is on the performance of wall systems, and in particular, the moisture characteristics inside the wall cavity and in the wood sheathing. Furthermore, while this research will initially address new home construction, the goal is to address potential moisture issues in wall cavities of existing homes when insulation and air sealing improvements are made.

  9. High-R Walls for Remodeling. Wall Cavity Moisture Monitoring

    Energy Technology Data Exchange (ETDEWEB)

    Wiehagen, J. [NAHB Research Center Industry Partnership, Upper Marlboro, MD (United States); Kochkin, V. [NAHB Research Center Industry Partnership, Upper Marlboro, MD (United States)

    2012-12-01

    The focus of the study is on the performance of wall systems, and in particular, the moisture characteristics inside the wall cavity and in the wood sheathing. Furthermore, while this research will initially address new home construction, the goal is to address potential moisture issues in wall cavities of existing homes when insulation and air sealing improvements are made.

  10. Mechanical mechanism analysis of tension type anchor based on shear displacement method

    Institute of Scientific and Technical Information of China (English)

    XIAO Shu-jun; CHEN Chang-fu

    2008-01-01

    Based on the fact that the shear stress along anchorage segment is neither linearly nor uniformly distributed, the load transfer mechanism of the tension type anchor was studied and the mechanical characteristic of anchorage segment was analyzed. Shear stress-strain relationship of soil surrounding anchorage body was simplified into three-folding-lines model consisting of elastic phase, elasto-plastic phase and residual phase considering its softening eharaeteristic. Meanwhile, shear displacement method that has been extensively used in the analysis of pile foundation was introduced. Based on elasto-plastic theory, the distributions of displacement, shear stress and axial force along the anchorage segment of tension type anchor were obtained, and the formula for calculating the elastic limit load was also developed accordingly. Finally, an example was given to discuss the variation of stress and displacement in the anchorage segment with the loads exerted on the anchor, and a program was worked out to calculate the anchor maximum bearing capacity. The influence of some parameters on the anchor bearing capacity was discussed, and effective anchorage length was obtained simultaneously. The results show that the shear stress first increases and then decreases and finally trends to theresidual strength with increase of distance from bottom of the anchorage body, the displacement increases all the time with theincrease of distance from bottom of the anchorage body, and the increase of velocity gradually becomes greater.

  11. Maleimide-functionalized lipids that anchor polypeptides to lipid bilayers and membranes.

    Science.gov (United States)

    Elliott, J T; Prestwich, G D

    2000-01-01

    Two maleimide-containing diacylglycerol derivatives were synthesized to permit the anchoring of short peptides and longer polypeptides to phospholipid bilayers and membranes. The maleimide was introduced at the site normally occupied by a phospholipid headgroup. The first lipid, the dipalmitoyl ester of 1-maleimido-2,3-propanediol, was developed as a membrane anchor for extracellular domains of transmembrane proteins. The second anchoring lipid, in which the 3-position contained a 6-aminohexanoate, was designed for convenient modification with amine-reactive reporter groups. Specifically, the NBD fluorophore, 7-nitrobenzo-2-oxa-1, 3-diazole-aminohexanoic-N-hydroxysuccinimide ester, was attached to give an fluorescent anchoring reagent. Next, these reagents were applied to the anchoring of a C-terminally cysteamine-modified 8 kDa polypeptide that comprises the extracellular N-terminal domain of the human thrombin receptor, a transmembrane protease-activated receptor (PAR-1). Gel filtration and fluorescence analysis showed that the fluorescent lipopolypeptide spontaneously inserted into preformed phospholipid vesicles, but it did not insert into whole cell membranes. In contrast, the dipalmitoyl derivative could only be reconstituted into artificial membranes by mixing the lipopolypeptide and phospholipid before vesicle formation. These results suggest that biophysical interactions governing the lipopolypeptide insertion into artificial and cellular membranes may differ. The thiol-reactive lipidating reagents should be valuable materials for studying the structure and function of peptides and polypeptides at phospholipid bilayer surfaces. PMID:11087332

  12. Determination of azimuthal anchoring strength in twisted nematic liquid crystal cells using heterodyne polarimeter.

    Science.gov (United States)

    Yu, Tsung-Chih; Lo, Yu-Lung; Huang, Rei-Rong

    2010-09-27

    Two external-field-free methods are presented for measuring the azimuthal anchoring strength in twisted nematic liquid crystal (TNLC) cells. For asymmetrical TNLC samples, the twist angle is derived from the phase of the detected signal in a phase-sensitive heterodyne polarimeter and is then used to calculate the weak anchoring strength directly. The measurement resolution which is found to be about 0.01 μJ/m(2) makes the present method sensitive enough for the LC-based bio-sensing application. Using the proposed method, the weak azimuthal anchoring strength of a composite liquid crystal mixture (40% LCT-061153 + 60% MJO-42761) in contact with a plasma-alignment layer is found to be 7.19 μJ/m(2). For symmetrical TNLC samples, the liquid crystals are injected into a wedge cell, and the two-dimensional distributions of the twist angle and cell gap are extracted from the detected phase distribution using a genetic algorithm (GA). The azimuthal anchoring strength is then obtained by applying a fitting technique to the twist angle vs. cell gap curve. Utilizing the proposed approach, it is shown that the strong anchoring strength between a rubbed polyimide (PI) alignment layer and E7 liquid crystal is around 160 μJ/m(2) while that between a rubbed PI alignment layer and MLC-7023 liquid crystal is approximately 32 μJ/m(2). PMID:20941014

  13. Influences of surface and flexoelectric polarization on the effective anchoring energy in nematic liquid crystal

    Science.gov (United States)

    Guan, Rong-Hua; Ye, Wen-Jiang; Xing, Hong-Yu

    2015-10-01

    The physical effects on surface and flexoelectric polarization in a weak anchoring nematic liquid crystal cell are investigated systematically. We derive the analytic expressions of two effective anchoring energies for lower and upper substrates respectively as well as their effective anchoring strengths and corresponding tilt angles of effective easy direction. All of these quantities are relevant to the magnitudes of both two polarizations and the applied voltage U. Based on these expressions, the variations of effective anchoring strength and the tilt angle with the applied voltage are calculated for the fixed values of two polarizations. For an original weak anchoring hybrid aligned nematic cell, it may be equivalent to a planar cell for a small value of U and has a threshold voltage. The variation of reduced threshold voltage with reduced surface polarization strength is also calculated. The role of surface polarization is important without the adsorptive ions considered. Project supported by the National Natural Science Foundation of China (Grant Nos. 11274088, 11374087, and11304074), the Natural Science Foundation of Hebei Province, China (Grant No. A2014202123), the Research Project of Hebei Provincial Education Department, China (Grant No. QN2014130), and the Key Subject Construction Project of Hebei Provincial University, China.

  14. A development of numerical analysis model for tensile capacity evaluation of cast-in-place anchor

    International Nuclear Information System (INIS)

    Numerical analysis is carried out to identify the appropriateness of the design codes that is available for the tensile design of fastening system at Nuclear Power Plant (NPP) in this study. This study is intended for the cast-in-place anchor that is widely used for the fastening of equipment in Korean NPPs. The microplane model and the elastic-perfectly plastic model are employed for the quasi-brittle material like concrete and for the ductile material like anchor bolt as constitutive model for numerical analysis and smeared crack model is employed for the crack and damage phenomena. The developed numerical model is verified on a basis of the various test data of cast-in-place anchor. The appropriateness of both ACI 349 Code and CCD approach of CEB-FIP Code is evaluated for the tensile design of cast-in-place anchor and it is proved that both design codes give a conservative results compared with real tensile capacity of cast-in-place anchor

  15. Interference Screw vs. Suture Anchor Fixation for Open Subpectoral Biceps Tenodesis: Does it Matter?

    Directory of Open Access Journals (Sweden)

    Gobezie Reuben

    2008-09-01

    Full Text Available Abstract Background Bioabsorbable interference screw fixation has superior biomechanical properties compared to suture anchor fixation for biceps tenodesis. However, it is unknown whether fixation technique influences clinical results. Hypothesis We hypothesize that subpectoral interference screw fixation offers relevant clinical advantages over suture anchor fixation for biceps tenodesis. Study Design Case Series. Methods We performed a retrospective review of a consecutive series of 88 patients receiving open subpectoral biceps tenodesis with either interference screw fixation (34 patients or suture anchor fixation (54 patients. Average follow up was 13 months. Outcomes included Visual Analogue Pain Scale (0–10, ASES score, modified Constant score, pain at the tenodesis site, failure of fixation, cosmesis, deformity (popeye and complications. Results There were no failures of fixation in this study. All patients showed significant improvement between their preoperative and postoperative status with regard to pain, ASES score, and abbreviated modified Constant scores. When comparing IF screw versus anchor outcomes, there was no statistical significance difference for VAS (p = 0.4, ASES score (p = 0.2, and modified Constant score (P = 0.09. One patient (3% treated with IF screw complained of persistent bicipital groove tenderness, versus four patients (7% in the SA group (nonsignificant. Conclusion Subpectoral biceps tenodesis reliably relieves pain and improves function. There was no statistically significant difference in the outcomes studied between the two fixation techniques. Residual pain at the site of tenodesis may be an issue when suture anchors are used in the subpectoral location.

  16. A Study on the Holding Capacity Safety Factors for Torpedo Anchors

    Directory of Open Access Journals (Sweden)

    Luís V. S. Sagrilo

    2012-01-01

    Full Text Available The use of powerful numerical tools based on the finite-element method has been improving the prediction of the holding capacity of fixed anchors employed by the offshore oil industry. One of the main achievements of these tools is the reduction of the uncertainty related to the holding capacity calculation of these anchors. Therefore, it is also possible to reduce the values of the associated design safety factors, which have been calibrated relying on models with higher uncertainty, without impairing the original level of structural safety. This paper presents a study on the calibration of reliability-based safety factors for the design of torpedo anchors considering the statistical model uncertainty evaluated using results from experimental tests and their correspondent finite-element-based numerical predictions. Both working stress design (WSD and load and resistance factors design (LRFD design methodologies are investigated. Considering the WSD design methodology, the single safety is considerably lower than the value typically employed in the design of torpedo anchors. Moreover, a LRFD design code format for torpedo anchors is more appropriate since it leads to designs having less-scattered safety levels around the target value.

  17. Automatic Wall Painting Robot

    Directory of Open Access Journals (Sweden)

    P.KEERTHANAA, K.JEEVITHA, V.NAVINA, G.INDIRA, S.JAYAMANI

    2013-07-01

    Full Text Available The Primary Aim Of The Project Is To Design, Develop And Implement Automatic Wall Painting Robot Which Helps To Achieve Low Cost Painting Equipment. Despite The Advances In Robotics And Its Wide Spreading Applications, Interior Wall Painting Has Shared Little In Research Activities. The Painting Chemicals Can Cause Hazards To The Human Painters Such As Eye And Respiratory System Problems. Also The Nature Of Painting Procedure That Requires Repeated Work And Hand Rising Makes It Boring, Time And Effort Consuming. When Construction Workers And Robots Are Properly Integrated In Building Tasks, The Whole Construction Process Can Be Better Managed And Savings In Human Labour And Timing Are Obtained As A Consequence. In Addition, It Would Offer The Opportunity To Reduce Or Eliminate Human Exposure To Difficult And Hazardous Environments, Which Would Solve Most Of The Problems Connected With Safety When Many Activities Occur At The Same Time. These Factors Motivate The Development Of An Automated Robotic Painting System.

  18. Scalable Resolution Display Walls

    KAUST Repository

    Leigh, Jason

    2013-01-01

    This article will describe the progress since 2000 on research and development in 2-D and 3-D scalable resolution display walls that are built from tiling individual lower resolution flat panel displays. The article will describe approaches and trends in display hardware construction, middleware architecture, and user-interaction design. The article will also highlight examples of use cases and the benefits the technology has brought to their respective disciplines. © 1963-2012 IEEE.

  19. In a walled garden

    OpenAIRE

    Mullaniff, Kathleen

    2009-01-01

    Mullaniff exhibited one painting from the series, ‘in a walled garden’. These works are based on a Victorian garden at St Leonards on Sea. An investigation into the history of the house and garden built 1860. This research endeavors to explore the progression of restoring the original Victorian garden, as recorded through the painting and drawing process This involves forming links between the past domestic histories and the current site. The research is based on the botanical paintings of Ma...

  20. Light shining through walls

    Energy Technology Data Exchange (ETDEWEB)

    Redondo, Javier [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Max-Planck-Institut fuer Physik, Muenchen (Germany); Ringwald, Andreas [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2010-11-15

    Shining light through walls? At first glance this sounds crazy. However, very feeble gravitational and electroweak effects allow for this exotic possibility. Unfortunately, with present and near future technologies the opportunity to observe light shining through walls via these effects is completely out of question. Nevertheless there are quite a number of experimental collaborations around the globe involved in this quest. Why are they doing it? Are there additional ways of sending photons through opaque matter? Indeed, various extensions of the standard model of particle physics predict the existence of new particles called WISPs - extremely weakly interacting slim particles. Photons can convert into these hypothetical particles, which have no problems to penetrate very dense materials, and these can reconvert into photons after their passage - as if light was effectively traversing walls. We review this exciting field of research, describing the most important WISPs, the present and future experiments, the indirect hints from astrophysics and cosmology pointing to the existence of WISPs, and finally outlining the consequences that the discovery of WISPs would have. (orig.)

  1. Light shining through walls

    International Nuclear Information System (INIS)

    Shining light through walls? At first glance this sounds crazy. However, very feeble gravitational and electroweak effects allow for this exotic possibility. Unfortunately, with present and near future technologies the opportunity to observe light shining through walls via these effects is completely out of question. Nevertheless there are quite a number of experimental collaborations around the globe involved in this quest. Why are they doing it? Are there additional ways of sending photons through opaque matter? Indeed, various extensions of the standard model of particle physics predict the existence of new particles called WISPs - extremely weakly interacting slim particles. Photons can convert into these hypothetical particles, which have no problems to penetrate very dense materials, and these can reconvert into photons after their passage - as if light was effectively traversing walls. We review this exciting field of research, describing the most important WISPs, the present and future experiments, the indirect hints from astrophysics and cosmology pointing to the existence of WISPs, and finally outlining the consequences that the discovery of WISPs would have. (orig.)

  2. Canal Wall Reconstruction Mastoidectomy

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Objective To investigate the advantages of canal wall reconstruction (CWR) mastoidectomy, a single-stage technique for cholesteatoma removal and posterior external canal wall reconstruction, over the open and closed procedures in terms of cholesteatoma recurrence. Methods: Between June 2002 and December 2005, 38 patients (40 ears) with cholesteatoma were admited to Sun Yat-Sen Memorial Hospital and received surgical treatments. Of these patients, 25 were male with ages ranging between 11 and 60 years (mean = 31.6 years) and 13 were female with ages ranging between 20 and 65 years (mean = 38.8 years). Canal wall reconstruction (CWR)mastoidectomy was performed in 31 ears and canal wall down (CWD) mastoidectomy in 9 ears. Concha cartilage was used for ear canal wall reconstruction in 22 of the 31 CWR procedures and cortical mastoid bone was used in the remaining 9 cases. Results At 0.5 to 4 years follow up, all but one patients remained free of signs of cholesteatoma recurrence, i.e., no retraction pocket or cholesteatoma matrix. One patient, a smoker, needed revision surgery due to cholesteatoma recurrence 1.5 year after the initial operation. The recurrence rate was therefore 3.2% (1/31). Cholesteatoma recurrence was monitored using postoperative CT scans whenever possible. In the case that needed a revision procedure, a retraction pocket was identified by otoendoscopy in the pars flacida area that eventually evolved into a cholesteatoma. A pocket extending to the epitympanum filled with cholesteatoma matrix was confirmed during the revision operation, A decision to perform a modified mastoidectomy was made as the patient refused to quit smoking. The mean air-bone gap in pure tone threshold was 45 dB before surgery and 25 dB after (p < 0.05). There was no difference between using concha cartilage and cortical mastoid bone for the reconstruction regarding air-bone gap improvement, CT findings and otoendoscopic results. Conclusion CWR mastoidectomy can be used for

  3. Traction endurance biomechanical study of metallic suture anchors at different insertion angles

    Directory of Open Access Journals (Sweden)

    Azato Flávia Namie

    2003-01-01

    Full Text Available The suture anchors' insertion angle and its traction resistance are the main subjects of this study. Twenty trials were realized using threaded suture anchors in four diferents angulations (30º /45º /60º /90º in human bone (distal femur and another twenty trials in artificial bone (SawboneTM. The anchors were pulled out being tractioned uprightly from its bone surface by a Kratos Universal test machine. The human bone results found no relation between the main subjects of this study, so whithout statistical value. On the other hand at the artificial bone the insertion angle of 90º beared more traction, being statistically significant compared to the other angles.

  4. Capacidad de carga de las anclas de plataformas petroleras. // Load capacity of oil platforms anchors.

    Directory of Open Access Journals (Sweden)

    J. García de la Figal Costales

    2001-07-01

    Full Text Available Se determina la capacidad de carga de las anclas de solicitación vertical, empleadas en la fijación de las plataformasperforadoras de petróleo de aguas profundas. Para ello, se desarrollan varios modelos del proceso de retención del ancla enel fango del fondo marino por medio del método de los Elementos Finitos. Se analizan con ellos, la influencia de variosparámetros en la capacidad de carga.Palabras claves: ancla, petróleo, elementos finitos, plataformas petroleras._________________________________________________________________________________AbstractThe load capacity of anchors for vertical fixation used as petroleum perforators platforms on deep waters are determined.Several models of retention process of the anchor are developed by means of Finite Elements Method and the influence ofseveral parameters in the load capacity are analized.Key words: anchors, petroleum, Finite Elements Method (FEM.

  5. Computing of the Anchor by the Method of Three-Dimension Point-Radiate Infinite Elements

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    On the basis of the one-dimension infinite element theory, the coordinate translation and shape function of 3D point-radiate 8-node and 4-node infinite elements are derived. They are coupled with 20-node and 8-node finite elements to compute the compression distortion of the prestressed anchorage segment. The results indicate that when the prestressed force acts on the anchorage head and segment, the stresses and the displacements in the rock around the anchorage head and segment concentrate on the zone center with the anchor axis, and they decrease with exponential forms. Therefore,the stresses and the displacement spindles are formed. The calculating results of the infinite element are close to the theoretical results. This indicates the method is right. This article introduces a new way to study the mechanism of prestressed anchors. The obtained results have an important role in the research of the anchor mechanism and engineering application.

  6. The anchoring function: parental authority and the parent-child bond.

    Science.gov (United States)

    Omer, Haim; Steinmetz, Sarit G; Carthy, Tal; von Schlippe, Arist

    2013-06-01

    Descriptions of parental authority and of the formation of a secure parent-child bond have remained unconnected in conceptualizations about parenting and child development. The parental anchoring function is here presented as an integrative metaphor for the two fields. Parents who fulfill an anchoring function offer a secure relational frame for the child, while also manifesting a stabilizing and legitimate kind of authority. The anchoring function enriches the two fields by: (1) adding a dimension of authority to the acknowledged functions of the safe haven and the secure base that are seen as core to a secure parent-child bond, and (2) adding considerations about the parent-child bond to Baumrind's classical description of authoritative parenting. PMID:23763680

  7. Simulation experiment on anti-penetration capability of anchored rock mass

    Institute of Scientific and Technical Information of China (English)

    Xia Songlin; Liu Hongwei; Han Lijun; Xu Guoan

    2011-01-01

    In order to solve the problem of experimental research on the penetration process of projectile into anchored rock mass,we derived the essential similarity conditions for the physical simulation experiment according to the similarity theory,carried out the experiment on the penetration process of a kind of penetrating bomb into the anchored rock mass of type Ⅲ,and compared the experimental results with the values computed by the professional Young's empirical formula.The test results show that the physical simulation experiment can represent the actual penetration process of projectile into anchored rock mass.The research method proposed in this paper provides technical support for the experimental research on the design and reconstruction of underground protection works.

  8. Career anchor profiles of a sample of business and professional women

    Directory of Open Access Journals (Sweden)

    Ronel Erwee

    1990-06-01

    Full Text Available The career anchors of a sample of 95 business and professional woman were studied by means of the Career Orientations Inventory (DeLong, 1982. The hierarchy of career anchors of the sample was as follows: Service, Variety, Security (job tenure, Managerial competence. Autonomy, Identity, Technical/functional competence, Entrepreneurship and Security (geographical location. A few significant differences in career anchors did occur between various occupational groups. The implicatons of these findings in terms of career management in organisations are discussed. Opsomming Die loopbaanankers van 'n steekproef van 95 sake- en beroepsvroue is bestudeer deur middel van die "Career Orientations Inventory" (DeLong, 1982. Die steekproef het die volgende hierargie van loopbaanankers getoon: Diens, Verskeidenheid, Sekuriteit (organisatories, Bestuursbevoegdheid, Outonomie, Identiteit, Tegnies/funksionele bevoegdheid, Entrepreneurskap en Sekuriteit (geografies. 'n Paar beduidende verskille in loopbaanankerprofiele het tussen die onderskeie beroepsgroepe voorgekom. Die implikasies van die bevindings ten opsigte van loopbaanbeplanning in ondernemings word bespreek.

  9. Analysis of Cracking Mode of Anchor Structure of Underground Engineering Induced by Reinforcement Corrosion

    Directory of Open Access Journals (Sweden)

    Wantao Ding

    2014-02-01

    Full Text Available Based on elastic theory and assumption of maximum tensile-stress failure criterion, together with construction process of anchor structure and rust expansion critical process, this study proposed a simplified reinforcement rust expansion mechanical model of anchor structure system. Elastic criterion of different initial cracking mode was rewarded under different stress ratios. According to analysis of critical cracking mode of different medium, cracking order of mortar and surrounding rock depended on their material parameters, in-situ stress and thickness of mortar cover. Critical cracking conditions of different medium without effect of in-situ stress was the same as that of considering in-situ stress while k is equal to 3 or 1/3. And engineering example shows that three different cracking modes exist under different stress ratios. The result provides a useful reference for analysis of mechanical deterioration mechanism of anchor structure and design of support structure of underground engineering.

  10. Anchor-free NEMS non-volatile memory cell for harsh environment data storage

    International Nuclear Information System (INIS)

    This work demonstrates a novel anchor-free nano-electromechanical (NEMS) based non-volatile memory cell, suitable for high temperature (T ≤ 300 °C) and radiation prone harsh environment applications. The anchor-free circular metal beam is actuated by electrostatic force and is held in one of the bi-stable memory states by adhesion force between two smooth metal surfaces in contact. Smooth metal layers form strong van der Waals stiction between two surfaces in contact and memory detection (Logic-‘1’ / Logic-‘0’) is obtained by detecting the conductance between two fixed contacts. This anchor-free design offers highest density (9F2 footprint) compared to other mechanical memory devices reported to date. (paper)

  11. Cell Wall Biology: Perspectives from Cell Wall Imaging

    Institute of Scientific and Technical Information of China (English)

    Kieran J.D.Lee; Susan E.Marcus; J.Paul Knox

    2011-01-01

    Polysaccharide-rich plant cell walls are important biomaterials that underpin plant growth,are major repositories for photosynthetically accumulated carbon,and,in addition,impact greatly on the human use of plants. Land plant cell walls contain in the region of a dozen major polysaccharide structures that are mostly encompassed by cellulose,hemicelluloses,and pectic polysaccharides. During the evolution of land plants,polysaccharide diversification appears to have largely involved structural elaboration and diversification within these polysaccharide groups. Cell wall chemistry is well advanced and a current phase of cell wall science is aimed at placing the complex polysaccharide chemistry in cellular contexts and developing a detailed understanding of cell wall biology. Imaging cell wall glycomes is a challenging area but recent developments in the establishment of cell wall molecular probe panels and their use in high throughput procedures are leading to rapid advances in the molecular understanding of the spatial heterogeneity of individual cell walls and also cell wall differences at taxonomic levels. The challenge now is to integrate this knowledge of cell wall heterogeneity with an understanding of the molecular and physiological mechanisms that underpin cell wall properties and functions.

  12. A general pipeline for the development of anchor markers for comparative genomics in plants

    Directory of Open Access Journals (Sweden)

    Stougaard Jens

    2006-08-01

    Full Text Available Abstract Background Complete or near-complete genomic sequence information is presently only available for a few plant species representing a large phylogenetic diversity among plants. In order to effectively transfer this information to species lacking sequence information, comparative genomic tools need to be developed. Molecular markers permitting cross-species mapping along co-linear genomic regions are central to comparative genomics. These "anchor" markers, defining unique loci in genetic linkage maps of multiple species, are gene-based and possess a number of features that make them relatively sparse. To identify potential anchor marker sequences more efficiently, we have established an automated bioinformatic pipeline that combines multi-species Expressed Sequence Tags (EST and genome sequence data. Results Taking advantage of sequence data from related species, the pipeline identifies evolutionarily conserved sequences that are likely to define unique orthologous loci in most species of the same phylogenetic clade. The key features are the identification of evolutionarily conserved sequences followed by automated design of intron-flanking Polymerase Chain Reaction (PCR primer pairs. Polymorphisms can subsequently be identified by size- or sequence variation of PCR products, amplified from mapping parents or populations. We illustrate our procedure in legumes and grasses and exemplify its application in legumes, where model plant studies and the genome- and EST-sequence data available have a potential impact on the breeding of crop species and on our understanding of the evolution of this large and diverse family. Conclusion We provide a database of 459 candidate anchor loci which have the potential to serve as map anchors in more than 18,000 legume species, a number of which are of agricultural importance. For grasses, the database contains 1335 candidate anchor loci. Based on this database, we have evaluated 76 candidate anchor loci

  13. Diagnosis of traction electric motor at irregularity in speed of anchor rotation

    Directory of Open Access Journals (Sweden)

    D.V. Cyernyayev

    2013-06-01

    Full Text Available Purpose. To offer a complex diagnostic parameter (or system of parameters that would allow determining the fault of electric traction motor as well as electromagnetic and mechanical nature. Methodology. Technology transition to maintenance and repair of equipment in accordance with its actual condition are developed rapidly in the world practice in recent years. Control of equipment and forecasting of its technical condition with the use of non-destructive testing and diagnosis in-place methods is the basis of such technologies. In operation the reliability level of electrical machines including traction electric motor is very difficult to maintain. Analyzing failures of rolling stock, which arise from the operation, we can see that traction electric motors are the least reliable nodes. Diagnostics of traction electric motor at irregularity in speed of anchor rotation is proposed. A measurement device for irregularity in speed of anchor rotation was developed. Findings. An experimental research in order to determine the irregularity in speed of anchor armature shaft rotation and coupling of irregularity in speed of anchor rotation with traction electric motors nodes failures was executed. The experimental dependence of the waveform uneven rotation anchor for engines with different technical conditions. Originality. A method for diagnosis of traction electric motors at irregularity in speed of anchor armature shaft rotation was first proposed. This method after further improvement can be used at bench test of engines in their work without load and for the quality of the repair. Practical value. The device for detecting defects of the traction electric motor nodes as well as electromagnetic and mechanical nature without engine disassembly may be used for control of engine assembly after repair, and at testing of traction electric motor without load.

  14. Bottlebrush Polymer Synthesis by Ring-Opening Metathesis Polymerization: The Significance of the Anchor Group.

    Science.gov (United States)

    Radzinski, Scott C; Foster, Jeffrey C; Chapleski, Robert C; Troya, Diego; Matson, John B

    2016-06-01

    Control over bottlebrush polymer synthesis by ring-opening metathesis polymerization (ROMP) of macromonomers (MMs) is highly dependent on the competition between the kinetics of the polymerization and the lifetime of the catalyst. We evaluated the effect of anchor group chemistry-the configuration of atoms linking the polymer to a polymerizable norbornene-on the kinetics of ROMP of polystyrene and poly(lactic acid) MMs initiated by (H2IMes)(pyr)2(Cl)2Ru═CHPh (Grubbs third generation catalyst). We observed a variance in the rate of propagation of >4-fold between similar MMs with different anchor groups. This phenomenon was conserved across all MMs tested, regardless of solvent, molecular weight (MW), or repeat unit identity. The observed >4-fold difference in propagation rate had a dramatic effect on the maximum obtainable backbone degree of polymerization, with slower propagating MMs reducing the maximum bottlebrush MW by an order of magnitude (from ∼10(6) to ∼10(5) Da). A chelation mechanism was initially proposed to explain the observed anchor group effect, but experimental and computational studies indicated that the rate differences likely resulted from a combination of varying steric demands and electronic structure among the different anchor groups. The addition of trifluoroacetic acid to the ROMP reaction substantially increased the propagation rate for all anchor groups tested, likely due to scavenging of the pyridine ligands. Based on these data, rational selection of the anchor group is critical to achieve high MM conversion and to prepare pure, high MW bottlebrush polymers by ROMP grafting-through. PMID:27219866

  15. Prediction of the pull-out strength of chemical anchors in natural stone

    Directory of Open Access Journals (Sweden)

    L. Contrafatto

    2014-07-01

    Full Text Available The applicability of some numerical models for the prediction of the failure mechanism and of the bearing capacity of post-installed threaded rods chemically anchored in basalt, sandstone and limestone is investigated, as well as the reliability of theoretical formulations conceived for concrete. The numerical predictions, performed by means of engineering structural analysis software and advanced numerical codes, are compared with the results of an experimental research related to chemical anchors in natural stone. The minimum embedment depth for such fastening system is identified.

  16. Exploring body-anchored and experience-based learning in a community of practice

    DEFF Research Database (Denmark)

    Stelter, Reinhard

    The article aims to integrate body-anchored and experience-based learning in the theoretical concept of learning in a community of practice. Present moment, epoché, intentional orientation and meaning making are introduced as the four basic premises for body-anchored and experience-based learning...... which, in a second step, is presented as part of the social realm and as one of the prerequisites of learning in a community of practice. This integration is established and becomes visible through the following two concepts: 1. Reification as the outflow of co-ordinated action, and 2. narratives as the...

  17. Organisation, ‘anchoring’ of knowledge, and innovation in the construction industry

    DEFF Research Database (Denmark)

    Drejer, Ina; Vinding, Anker Lund

    2004-01-01

    other interorganisational features, combined with internal product and process evaluation and knowledge diffusion, are more likely to engage in innovative activities than firms that make less use of what we label ?knowledge anchoring mechanisms?. This indicates that there are ways for firms to......explanation for the relatively poor innovation performance of the industry. Using survey data from the Danish construction industry the paper investigates the importance of learning and ?anchoring? of project specific knowledge within the firms for facilitating engagement in innovative activities...

  18. Ancient technology of jetties and anchoring points along the west coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Gaur, A.S.; Vora, K.H.

    , majority of these anchors belong to ring stone-type (Figure 9). The port plays a dominant role in facilitating sea trade. There have been several ports all along the Indian coast since antiquity. A prerequisite for the selection of any port site... variation and seabed topography played a signifi- cant role in the construction of jetties. As stated earlier, the higher tidal variation in Gujarat has been used by navigators to anchor boats in the inter-tidal zone; thus loading and unloading become...

  19. Approaches to enhance body-anchored and experience-based learning

    DEFF Research Database (Denmark)

    Stelter, Reinhard

    2008-01-01

    Subsequent to the theoretical framework presented in the two earlier contributions to this volume ("Learning Bodies")the aim of this article is to unfold some ideas for the application of body-anchored learning. Some of the basic principles like focusing, perceptual attention training, being in the...... rhythm and intentional orientation can also be applied to different areas, for example, psychotherapy or coaching. But the main focus is on examples from physical education. The final part of the article sees body-anchored learning as integrated in a cultural setting and as part of learning in a...

  20. Fixation of a human rib by an intramedullary telescoping splint anchored by bone cement.

    Science.gov (United States)

    Liovic, Petar; Šutalo, Ilija D; Marasco, Silvana F

    2016-09-01

    A novel concept for rib fixation is presented that involves the use of a bioresorbable polymer intramedullary telescoping splint. Bone cement is used to anchor each end of the splint inside the medullary canal on each side of the fracture site. In this manner, rib fixation is achieved without fixation device protrusion from the rib, making the splint completely intramedullary. Finite element analysis is used to demonstrate that such a splint/cement composite can preserve rib fixation subjected to cough-intensity force loadings. Computational fluid dynamics and porcine rib experiments were used to study the anchor formation process required to complete the fixation. PMID:26733094

  1. Technical note: Endoscopic resection of a dermoid cyst anchored to the anterior optic chiasm

    Directory of Open Access Journals (Sweden)

    Yuichiro Yoneoka, MD, PhD

    2014-06-01

    Conclusion: To the best of our knowledge, ours is the only case of a dermoid cyst anchored to the anterior optic chiasma, which was visually confirmed under endoscopic observation. After surgery, the patient presented a transient impairment of the visual field, which was not evident at four month follow-up. It will contribute to a similar case, in which surgeons hesitate to make an incision in the optic chiasm. A subtotal excision should be considered in cases of dermoid cysts anchored to the anterior optic chiasm, because all the previously reported cases of suprasellar dermoid cysts are young people or those who have a relatively long life expectancy.

  2. Interaction of Rupture Zones of Adjacent Anchor Plates in an Analogical Medium

    Directory of Open Access Journals (Sweden)

    H. Abbad

    2013-12-01

    Full Text Available In this paper, an experimental study which required the design and implementation of a model containing plastic granules powder to simulate a natural environment, is presented. The latter is subjected to the removal of "anchor plates." For each test, several digital photographs are taken to materialize different deformed configurations during the pullout process. These photos processed in couples by the 7D software (image correlation giving the evolution of the displacement field and plane strain analogical environment. Particular attention is paid to the discussion of the interference of rupture zones of neighboring anchors by reducing the axis between plates.

  3. Thick-Walled Cylinder Theory Applied on a Conical Wedge Anchorage

    DEFF Research Database (Denmark)

    Bennitz, Anders; Grip, Niklas; Schmidt, Jacob Wittrup

    2011-01-01

    Conical wedge anchorages are frequently used to anchor steel tendons in prestressing applications within the construction industry. To replace the steel tendons with non-corrosive and low weight FRPs (Fiber Reinforced Polymers), the different mechanical interactions between the steel and FRPs call...... for further development of the anchorage.In this paper, we derive and examine an analytical model for the internal stresses and strains within the anchorage for a prescribed presetting distance. This model is derived from the theory of thick walled cylinders under the assumptions regarding plane...

  4. Correlations of coronary plaque wall thickness with wall pressure and wall pressure gradient: a representative case study

    OpenAIRE

    Liu Biyue; Zheng Jie; Bach Richard; Tang Dalin

    2012-01-01

    Abstract Background There are two major hemodynamic stresses imposed at the blood arterial wall interface by flowing blood: the wall shear stress (WSS) acting tangentially to the wall, and the wall pressure (WP) acting normally to the wall. The role of flow wall shear stress in atherosclerosis progression has been under intensive investigation, while the impact of blood pressure on plaque progression has been under-studied. Method The correlations of wall thickness (WT) with wall pressure (WP...

  5. Forward Wall Detector

    International Nuclear Information System (INIS)

    The Forward Wall Detector is designed to identify projectile like fragments from heavy ion reactions at CELSIUS storage ring in Uppsala, Sweden. The FWD consist of 96 detection modules covering azimuthal angle from 3.9o to 11.7o with efficiency of 81%. The detection module can be either of phoswitch type (10 mm fast plastic + 80 mm CsI(Tl)) or standard ΔE-E telescope (750 μm Si + 88 mm CsI(Tl)). It is expected to have charge identification up to Z=18, mass resolution for H and He isotopes and energy resolution ∼ 8%. (author)

  6. Scheme Comparison and Selection for Anchor Foundation of Maputo Bridge in Mozambique%莫桑比克马普托大桥锚碇基础方案比选

    Institute of Scientific and Technical Information of China (English)

    周健; 邹恩杰; 李元博; 孟令亮

    2014-01-01

    莫桑比克马普托(M aputo )大桥主桥为单跨680 m悬索桥,为确定马普托大桥锚碇基础方案,依据大桥桥位处的地质和水文情况,以及重力式锚碇的结构受力特点,针对锚碇基础基底持力层选择、施工工艺的适用性、技术可行性、经济性、合理性,分别对沉井基础和地下连续墙基础进行研究。研究结果表明:采用地下连续墙基础,施工期间可以避免由于地质情况变化带来的风险,如翻砂、突涌等;可以严格控制锚碇基础施工过程中对周围土体造成的沉降,最大限度地减少对周围铁路正常运营的影响。在确定地下连续墙基础形式后,针对施工过程中的突涌问题,对深地下连续墙和浅地下连续墙+灌浆帷幕+深井抽排水降低水头方案进行研究。研究结果表明:采用深地下连续墙基础,投入设备相对单一,施工工艺、工序简单,施工工效相对较高,施工工期较短,工期可控,应为马普托大桥合理的锚碇基础方案。%The main bridge of Maputo Bridge in Mozambique is a suspension bridge with a sin‐gle span of 680 m .In order to make a rational anchor foundation scheme ,the types of caisson foundation and underground diaphragm wall were studied in accordance with the geological and hydrological condition at the bridge site and the load bearing characteristics of gravity anchor .I‐tems such as the selection of the base bearing stratum for the anchor foundation ,feasibility of the construction techniques and the applicability ,economic performance and rationality of the tech‐niques were also taken into account in the study .The results of the study indicate that the adapta‐tion of the underground diaphragm wall foundation is able to avoid the risks induced by variation of geological condition ,such as quicksand and heavy‐piping ,and is possible to strictly control the surrounding soil settlement during the

  7. The Role of Anchor Stations in the Validation of Earth Observation Satellite Data and Products. The Valencia and the Alacant Anchor Stations

    Science.gov (United States)

    Lopez-Baeza, Ernesto; Geraldo Ferreira, A.; Saleh-Contell, Kauzar

    Space technology facilitates humanity and science with a global revolutionary view of the Earth through the acquisition of Earth Observation satellite data. Satellites capture information over different spatial and temporal scales and assist in understanding natural climate processes and in detecting and explaining climate change. Accurate Earth Observation data is needed to describe climate processes by improving the parameterisations of different climate elements. Algorithms to produce geophysical parameters from raw satellite observations should go through selection processes or participate in inter-comparison programmes to ensure performance reliability. Geophysical parameter datasets, obtained from satellite observations, should pass a quality control before they are accepted in global databases for impact, diagnostic or sensitivity studies. Calibration and Validation, or simply "Cal/Val", is the activity that endeavours to ensure that remote sensing products are highly consistent and reproducible. This is an evolving scientific activity that is becoming increasingly important as more long-term studies on global change are undertaken, and new satellite missions are launched. Calibration is the process of quantitatively defining the system responses to known, controlled signal inputs. Validation refers to the process of assessing, by independent means, the quality of the data products derived from the system outputs. These definitions are generally accepted and most often used in the remote sensing context to refer specifically and respectively to sensor radiometric calibration and geophysical parameter validation. Anchor Stations are carefully selected locations at which instruments measure quantities that are needed to run, calibrate or validate models and algorithms. These are needed to quanti-tatively evaluate satellite data and convert it into geophysical information. The instruments collect measurements of basic quantities over a long timescale

  8. 15 CFR Appendix C to Subpart H of... - No-Anchoring Seagrass Protection Zones in Tomales Bay

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false No-Anchoring Seagrass Protection Zones in Tomales Bay C Appendix C to Subpart H of Part 922 Commerce and Foreign Trade Regulations Relating... 922—No-Anchoring Seagrass Protection Zones in Tomales Bay Coordinates listed in this Appendix...

  9. Control of the anchoring behavior of polymer-dispersed liquid crystals: effect of branching in the side chains of polyacrylates.

    Science.gov (United States)

    Zhou, Jian; Collard, David M; Park, Jung O; Srinivasarao, Mohan

    2002-08-28

    A temperature-driven anchoring transition in a polymer/nematic fluid composite that is far from the bulk nematic-isotropic transition temperature is reported. A series of poly(methylheptyl acrylates) were studied to probe the subtle effects of the side chain structure of the polymer on control of the anchoring. A polymer-dispersed liquid crystal film made from TL205 and 1-methylheptyl acrylate shows only planar anchoring over the temperature range studied, while the films made from TL205 and each of the other methylheptyl acrylates or n-heptyl acrylate show the homeotropic-to-planar anchoring transition at temperatures between 70 and 78 degrees C. An interfacial model is proposed in which the different conformation of the side chains is suggested as the cause for the dramatic difference in the observed anchoring behavior. PMID:12188649

  10. Auditory frequency discrimination in adult dyslexics: A test of the anchoring hypothesis

    NARCIS (Netherlands)

    Wijnen, F.N.K.; Kappers, A.M.L.; Vlutters, L.D.; Winkel, S.

    2012-01-01

    Purpose: A recent hypothesis ascribes dyslexia to a perceptual anchoring deficit. Supporting results have so far been obtained only in children with dyslexia and additional learning difficulties, but the hypothesis has been argued to apply to all individuals with dyslexia. Method: The authors measur

  11. Substrate-anchored and degradation-sensitive anti-inflammatory coatings for implant materials

    Science.gov (United States)

    Wu, Duo; Chen, Xingyu; Chen, Tianchan; Ding, Chunmei; Wu, Wei; Li, Jianshu

    2015-06-01

    Implant materials need to be highly biocompatible to avoid inflammation in clinical practice. Although biodegradable polymeric implants can eliminate the need for a second surgical intervention to remove the implant materials, they may produce acidic degradation products in vivo and cause non-bacterial inflammation. Here we show the strategy of “substrate-anchored and degradation-sensitive coatings” for biodegradable implants. Using poly(lactic acid)/hydroxyapatite as an implant material model, we constructed a layer-by-layer coating using pH-sensitive star polymers and dendrimers loaded with an anti-inflammatory drug, which was immobilised through a hydroxyapatite-anchored layer. The multifunctional coating can effectively suppress the local inflammation caused by the degradation of implant materials for at least 8 weeks in vivo. Moreover, the substrate-anchored coating is able to modulate the degradation of the substrate in a more homogeneous manner. The “substrate-anchored and degradation-sensitive coating” strategy therefore exhibits potential for the design of various self-anti-inflammatory biodegradable implant materials.

  12. A cell-surface-anchored ratiometric i-motif sensor for extracellular pH detection.

    Science.gov (United States)

    Ying, Le; Xie, Nuli; Yang, Yanjing; Yang, Xiaohai; Zhou, Qifeng; Yin, Bincheng; Huang, Jin; Wang, Kemin

    2016-06-14

    A FRET-based sensor is anchored on the cell surface through streptavidin-biotin interactions. Due to the excellent properties of the pH-sensitive i-motif structure, the sensor can detect extracellular pH with high sensitivity and excellent reversibility. PMID:27241716

  13. The anchoring mechanism of a bluff-body stabilized laminar premixed flame

    KAUST Repository

    Kedia, Kushal S.

    2014-09-01

    The objective of this work is to investigate the mechanism of the laminar premixed flame anchoring near a heat-conducting bluff-body. We use unsteady, fully resolved, two-dimensional simulations with detailed chemical kinetics and species transport for methane-air combustion. No artificial flame anchoring boundary conditions were imposed. Simulations show a shear-layer stabilized flame just downstream of the bluff-body, with a recirculation zone formed by the products of combustion. A steel bluff-body resulted in a slightly larger recirculation zone than a ceramic bluff-body; the size of which grew as the equivalence ratio was decreased. A significant departure from the conventional two-zone flame-structure is shown in the anchoring region. In this region, the reaction zone is associated with a large negative energy convection (directed from products to reactants) resulting in a negative flame-displacement speed. It is shown that the premixed flame anchors at an immediate downstream location near the bluff-body where favorable ignition conditions are established; a region associated with (1) a sufficiently high temperature impacted by the conjugate heat exchange between the heat-conducting bluff-body and the hot reacting flow and (2) a locally maximum stoichiometry characterized by the preferential diffusion effects. © 2014 The Combustion Institute.

  14. Discriminative ability of two different external anchors: improvement appears better than importance

    DEFF Research Database (Denmark)

    Lauridsen, Henrik Hein

    2009-01-01

    Title:    Discriminative ability of two different external anchors: improvement appears better than importance. Authors and affiliation: Henrik H. Lauridsen, DC, MSc, PhD*, Claus Manniche, MD, DMSc‡, Werner Vach, PhD §, Niels Grunnet-Nilsson DC, MD, PhD*, Jan Hartvigsen, DC, PhD*† * Clinical...

  15. Discriminative ability of two different external anchors: improvement appears better than importance

    DEFF Research Database (Denmark)

    Lauridsen, Henrik Hein

    Title:    Discriminative ability of two different external anchors: improvement appears better than importance. Authors and affiliation: Henrik H. Lauridsen, DC, MSc, PhD*, Claus Manniche, MD, DMSc‡, Werner Vach, PhD §, Niels Grunnet-Nilsson DC, MD, PhD*, Jan Hartvigsen, DC, PhD*†   * Clinical...

  16. Anchor-Based Methods for Judgmentally Estimating Item Difficulty Parameters. LSAC Research Report Series.

    Science.gov (United States)

    Hambleton, Ronald K.; Sireci, Stephen G.; Swaminathan, H.; Xing, Dehui; Rizavi, Saba

    The purposes of this research study were to develop and field test anchor-based judgmental methods for enabling test specialists to estimate item difficulty statistics. The study consisted of three related field tests. In each, researchers worked with six Law School Admission Test (LSAT) test specialists and one or more of the LSAT subtests. The…

  17. Orbital Interaction Mechanisms of Conductance Enhancement and Rectification by Dithiocarboxylate Anchoring Group

    OpenAIRE

    Li, Zhenyu; Kosov, D. S.

    2006-01-01

    We study computationally the electron transport properties of dithiocarboxylate terminated molecular junctions. Transport properties are computed self-consistently within density functional theory and nonequilibrium Green's functions formalism. A microscopic origin of the experimentally observed current amplification by dithiocarboxylate anchoring groups is established. For the 4,4'-biphenyl bis(dithiocarboxylate) junction, we find that the interaction of the lowest unoccupied molecular orbit...

  18. Solid-phase oligosaccharide synthesis with tris(alkoxy)benzyl amine (BAL) safety-catch anchoring

    DEFF Research Database (Denmark)

    Tolborg, Jakob Fjord; Jensen, Knud Jørgen

    2000-01-01

    A tris(alkoxy)benzylamine (BAL) handle strategy was developed for safety-catch anchoring of D-glucosamine derivatives in solid-phase synthesis of oligosaccharides; the linkage between the BAL handle and the amine proved stable to conc. TFA and Lewis acids, but after N-acylation the amide could be...

  19. Human carbonic anhydrase II as a host for piano-stool complexes bearing a sulfonamide anchor.

    Science.gov (United States)

    Monnard, Fabien W; Heinisch, Tillmann; Nogueira, Elisa S; Schirmer, Tilman; Ward, Thomas R

    2011-08-01

    d(6)-piano-stool complexes bearing an arylsulfonamide anchor display sub-micromolar affinity towards human Carbonic Anhydrase II (hCA II). The 1.3 Å resolution X-ray crystal structure of [(η(6)-C(6)Me(6))Ru(bispy 3)Cl](+)⊂ hCA II highlights the nature of the host-guest interactions. PMID:21706094

  20. Peptide nanofibers modified with a protein by using designed anchor molecules bearing hydrophobic and functional moieties.

    Science.gov (United States)

    Miyachi, Ayaka; Takahashi, Tsuyoshi; Matsumura, Sachiko; Mihara, Hisakazu

    2010-06-11

    Self-assembly of peptides and proteins is a key feature of biological functions. Short amphiphilic peptides designed with a beta-sheet structure can form sophisticated nanofiber structures, and the fibers are available as nanomaterials for arranging biomolecules. Peptide FI (H-PKFKIIEFEP-OH) self-assembles into nanofibers with a coiled fine structure, as reported in our previous work. We have constructed anchor molecules that have both a binding moiety for the fiber structure and a functional unit capable of capturing target molecules, with the purpose of arranging proteins on the designed peptide nanofibers. Designed anchors containing an alkyl chain as a binding unit and biotin as a functional moiety were found to bind to peptide fibers FI and F2i (H-ALEAKFAAFEAKLA-NH(2)). The surface-exposed biotin moiety on the fibers could capture an anti-biotin antibody. Moreover, hydrophobic dipeptide anchor units composed of iminodiacetate connected to Phe-Phe or Ile-Ile and a peptide composed of six histidine residues connected to biotin could also connect FI peptide fibers to the anti-biotin antibody through the chelation of Ni(2+) ions. This strategy of using designed anchors opens a novel approach to constructing nanoscale protein arrays on peptide nanomaterials. PMID:20419712

  1. Understanding and valuing environmental issues: the effects of availability and anchoring on judgment.

    Science.gov (United States)

    van der Pligt, J; van Schie, E C; Hoevenagel, R

    1998-01-01

    This paper addresses the effects of availability and anchoring-and-adjustment on people's beliefs and values concerning environmental issues. The first three studies focus on lay people's perceptions of the causes of large scale environmental risks, the second series of three studies deals with how people value environmental goods and how much they are prepared to pay to mitigate environmental risks. In studies 1-3 we investigate the effects of availability and anchoring-and-adjustment on estimating the contribution of various factors to large scale environmental risks. Highly complex risks such as acid rain and global warming tend to be associated with multiple causes, and our results show that estimating the role of these causes is clearly affected by availability and anchoring-and-adjustment. Both have sizeable effects and persist over time. Moreover, corrective procedures only seem to have a limited effect. Availability and anchoring-and-adjustment not only play a role in judging the possible causes of risks; they also play a role in research attempting to assess the public's willingness to pay (WTP) to protect our environment. The outcomes of WTP surveys are often used as a tool to help policy decision making. In the second part of this article we present three studies on this issue. Results provide further evidence of the impact of the two heuristics on the outcomes of WTP research. Implications for research and practice are briefly discussed. PMID:9857823

  2. Neutron reflectivity of supported membranes incorporating terminally anchored polymers: Protrusions vs. blisters

    DEFF Research Database (Denmark)

    Fragneto, Giovanna; Halperin, Avraham; Klösgen-Buchkremer, Beate Maria; Sferrazza, Michele

    2013-01-01

    The effect of terminally anchored chains on the structure of lipid bilayers adsorbed at the solid/water interface was characterized by neutron reflectivity. In the studied system, the inner leaflet, closer to the substrate, consisted of head-deuterated 1,2-distearoyl-sn-glycero-3-phosphorylcholin...... blister-like membrane deformations....

  3. Side-chain-anchored N(alpha)-Fmoc-Tyr-OPfp for bidirectional solid-phase synthesis

    DEFF Research Database (Denmark)

    Olsen, Christian A; Jørgensen, Malene; Hansen, Steen H; Witt, Matthias; Jaroszewski, Jerzy W; Franzyk, Henrik

    2005-01-01

    [reaction: see text] A mild resin-immobilization strategy employing a readily prepared trityl bromide resin for anchoring building blocks via a phenol group has been developed. With N(alpha)-Fmoc-Tyr-OPfp as a starter building block, it was possible to prepare asymmetrically substituted hybrids o...

  4. Test results on the dynamic testing of expansion type concrete anchors

    Energy Technology Data Exchange (ETDEWEB)

    Barron, B.; Rice, R.; Stephen, R.M.

    1974-12-01

    Tests were performed to determine the structural response of commercially available expansion type anchors for the FFTF when subjected to dynamic loadings similar to machine vibrations and earthquakes. The specimens were subjected to tension, shear, and combined shear-tension loads.

  5. Test results on the dynamic testing of expansion type concrete anchors

    International Nuclear Information System (INIS)

    Tests were performed to determine the structural response of commercially available expansion type anchors for the FFTF when subjected to dynamic loadings similar to machine vibrations and earthquakes. The specimens were subjected to tension, shear, and combined shear-tension loads

  6. Influence of the order parameter on the anchoring energy of liquid crystals

    Energy Technology Data Exchange (ETDEWEB)

    Dadivanyan, A. K., E-mail: dadivank@mail.ru; Chausov, D. N., E-mail: d.chausov@yandex.ru [Moscow State Regional University (Russian Federation); Noa, O. V. [Moscow State University (Russian Federation); Belyaev, V. V. [Moscow State Regional University (Russian Federation); Chigrinov, V. G. [Hong Kong University of Science and Technology (China); Pashinina, Yu. M. [Moscow State Regional University (Russian Federation)

    2012-12-15

    No theory of the polar and azimuthal anchoring energies of liquid crystals (LCs) has been developed on a molecular level, despite the scientific and practical topicality of the problem. The interaction energies of mesogenic molecules with graphite and polyethylene surfaces calculated previously by the method of atom-atom potentials are in good agreement with the experimental data, but, at the same time, the calculated polar and azimuthal anchoring energies are larger than their experimental values by one and two orders of magnitude, respectively. To explain these values, the anchoring energy has been assumed to depend not only on the interaction with the surface but also on the interaction between the LC molecules arranged in the model in the form of quasi-layers. The mesogenic molecules have been modeled by rods with virtual C' atoms (carbon atoms with hydrogen atoms attached to them) 'threaded' on them. The molecule orientation has been specified by the polar and azimuthal angles {theta}{sub i}, {phi}{sub i} and {theta}{sub j}, {phi}{sub j} relative to the directors of the ith and jth layers. The derived polar and azimuthal anchoring energies as well as their dependences on the order parameter have turned out to be close to the experimental data.

  7. Influence of the order parameter on the anchoring energy of liquid crystals

    International Nuclear Information System (INIS)

    No theory of the polar and azimuthal anchoring energies of liquid crystals (LCs) has been developed on a molecular level, despite the scientific and practical topicality of the problem. The interaction energies of mesogenic molecules with graphite and polyethylene surfaces calculated previously by the method of atom-atom potentials are in good agreement with the experimental data, but, at the same time, the calculated polar and azimuthal anchoring energies are larger than their experimental values by one and two orders of magnitude, respectively. To explain these values, the anchoring energy has been assumed to depend not only on the interaction with the surface but also on the interaction between the LC molecules arranged in the model in the form of quasi-layers. The mesogenic molecules have been modeled by rods with virtual C’ atoms (carbon atoms with hydrogen atoms attached to them) “threaded” on them. The molecule orientation has been specified by the polar and azimuthal angles θi, φi and θj, φj relative to the directors of the ith and jth layers. The derived polar and azimuthal anchoring energies as well as their dependences on the order parameter have turned out to be close to the experimental data.

  8. Auditory Frequency Discrimination in Adults with Dyslexia: A Test of the Anchoring Hypothesis

    Science.gov (United States)

    Wijnen, Frank; Kappers, Astrid M. L.; Vlutters, Leoni D.; Winkel, Sven

    2012-01-01

    Purpose: A recent hypothesis ascribes dyslexia to a perceptual anchoring deficit. Supporting results have so far been obtained only in children with dyslexia and additional learning difficulties, but the hypothesis has been argued to apply to all individuals with dyslexia. Method: The authors measured auditory frequency discrimination thresholds…

  9. Operative treatment of acromioclavicular joint dislocation: a new technique with suture anchors

    Directory of Open Access Journals (Sweden)

    Zhang Jingwei

    2014-07-01

    Full Text Available 【Abstract】Objective: To evaluate clinical outcome of suture anchors in strengthening both acromioclavicular and coracoclavicular ligaments in the surgical treatment of acromioclavicular joint dislocation. Methods: Twenty-eight patients with acute traumatic Rockwood III, IV and V dislocations of the acromioclavicular joint surgically treated at our institute between October 2010 and January 2012 were recruited. All patients underwent open reduction combined with suture anchors. Function was evaluated using the ConstantMurley shoulder score. Clinical and radiographic shoulder ratings were evaluated using Taft criteria at 3, 6 and 12 months. Results:Two cases with fixation loosening were not included in final statistical analysis. Other patients obtained full joint reposition on immediate postoperative radiographs. Follow-up was performed with an average of 15.6 months (range, 12-19. After early range of motion exercises, 96.2% of the patients (25/26 could abduct and elevate their shoulders more than 90 degrees within postoperative 3 months. There was no infection. Average Constant-Murley score was 96.3 points (range, 94-100 and mean Taft shoulder rating was 10.7 points (range, 8-12 at 12 months. Conclusion: The suture anchor is a relatively simple technique and can avoid screw removal which is helpful in reconstructing both acromioclavicular and coracoclavicular ligaments in acute traumatic acromioclavicular joint dislocation. Key words: Acromioclavicular joint; Dislocations; Surgery; Suture anchors

  10. The Effect of Listener Experience and Anchors on Judgments of Dysphonia

    Science.gov (United States)

    Eadie, Tanya L.; Kapsner-Smith, Mara

    2011-01-01

    Purpose: To determine the effect of auditory anchors on judgments of overall severity (OS) and vocal effort (VE) in dysphonic speech when judgments are made by experienced and inexperienced listeners, and when self-rated by individuals with dysphonia (speaker-listeners). Method: Twenty individuals with dysphonia and 4 normal controls provided…

  11. Effects of Thinking Style and Spatial Ability on Anchoring Behavior in Geographic Information Systems

    Science.gov (United States)

    Wang, Dai-Yi; Lee, Mei-Hsuan; Sun, Chuen-Tsai

    2013-01-01

    The authors propose an instructional use for Google Earth (a GIS application) as an anchoring tool for knowledge integration. Google Earth can be used to support student explorations of world geography based on Wikipedia articles on earth science and history topics. We asked 66 Taiwanese high-school freshmen to make place marks with explanatory…

  12. Using Automated Essay Scores as an Anchor When Equating Constructed Response Writing Tests

    Science.gov (United States)

    Almond, Russell G.

    2014-01-01

    Assessments consisting of only a few extended constructed response items (essays) are not typically equated using anchor test designs as there are typically too few essay prompts in each form to allow for meaningful equating. This article explores the idea that output from an automated scoring program designed to measure writing fluency (a common…

  13. An improvement of design criteria for cast-in place anchor

    International Nuclear Information System (INIS)

    Actual model tests are carried out to examine the appropriateness of design criteria that is available for the anchorage design in this study. These tests are intended for the cast-in-place anchor that is widely used for the fastening of equipment in Korean NPPs. 35 test specimens taking account of 7 test conditions are manufactured on a basis of ASTM E488 under non-cracked and plain concrete for these actual model tests. As principal test variables, effective anchor embedment depth, anchor with edge effects, and anchor with overlapping failure volume etc. are chosen. In order to apply the tensile force, 100 tonf-capacity actuator is used with displacement control of 0.5 mm/min. It is proved that ACI 349-01 and CCD procedure of CEB- FIP Code are very conservative against test results through these actual model tests and the improved design criterion is proposed on a basis of test results in order to better the economical efficiency of NPPs in this study

  14. Arrows as Anchors: An Analysis of the Material Features of Electric Field Vector Arrows

    Science.gov (United States)

    Gire, Elizabeth; Price, Edward

    2014-01-01

    Representations in physics possess both physical and conceptual aspects that are fundamentally intertwined and can interact to support or hinder sense making and computation. We use distributed cognition and the theory of conceptual blending with material anchors to interpret the roles of conceptual and material features of representations in…

  15. The information-anchoring model of first offers: When moving first helps versus hurts negotiators.

    Science.gov (United States)

    Loschelder, David D; Trötschel, Roman; Swaab, Roderick I; Friese, Malte; Galinsky, Adam D

    2016-07-01

    Does making the first offer increase or impair a negotiator's outcomes? Past research has found evidence supporting both claims. To reconcile these contradictory findings, we developed and tested an integrative model-the Information-Anchoring Model of First Offers. The model predicts when and why making the first offer helps versus hurts. We suggest that first offers have 2 effects. First, they serve as anchors that pull final settlements toward the initial first-offer value; this anchor function often produces a first-mover advantage. Second, first offers can convey information on the senders' priorities, which makes the sender vulnerable to exploitation and increases the risk of a first-mover disadvantage. To test this model, 3 experiments manipulated the information that senders communicated in their first offer. When senders did not reveal their priorities, the first-mover advantage was replicated. However, when first offers revealed senders' priorities explicitly, implicitly, or both, a first-mover disadvantage emerged. Negotiators' social value orientation moderated this effect: A first-mover disadvantage occurred when senders faced proself recipients who exploited priority information, but not with prosocial recipients. Moderated mediation analyses supported the model assumptions: Proself recipients used their integrative insight to feign priorities in their low-priority issues and thereby claimed more individual value than senders. The final discussion reviews theoretical and applied implications of the Information-Anchoring Model of First Offers. (PsycINFO Database Record PMID:27065345

  16. Statistical Procedures to Evaluate Quality of Scale Anchoring. Research Report. ETS RR-11-02

    Science.gov (United States)

    Haberman, Shelby J.; Sinharay, Sandip; Lee, Yi-Hsuan

    2011-01-01

    Providing information to test takers and test score users about the abilities of test takers at different score levels has been a persistent problem in educational and psychological measurement (Carroll, 1993). Scale anchoring (Beaton & Allen, 1992), a technique that describes what students at different points on a score scale know and can do, is…

  17. Exploring the Affordances of Second Life Machinima as an Anchor for Classroom-Based Apprenticeship

    Science.gov (United States)

    Muldoon, Nona; Kofoed, Jennifer

    2011-01-01

    The research reported in this paper is part of an ongoing investigation into the design of a technology-enhanced learning environment that draws from approaches embodied in the situated learning theory. In this learning context, Second Life machinima (animated artefact filmed in a 3D virtual environment) is used as an anchor to mediate authentic…

  18. High-throughput physical map anchoring via BAC-pool sequencing

    Czech Academy of Sciences Publication Activity Database

    Cviková, Kateřina; Cattonaro, F.; Alaux, M.; Stein, N.; Mayer, K.F.X.; Doležel, Jaroslav; Bartoš, Jan

    2015-01-01

    Roč. 15, APR 11 (2015). ISSN 1471-2229 R&D Projects: GA ČR GA13-08786S; GA MŠk(CZ) LO1204 Institutional support: RVO:61389030 Keywords : Physical map * Contig anchoring * Next generation sequencing Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 3.813, year: 2014

  19. Bearing Capacity Analyses for the Great Belt East Bridge Anchor Blocks

    DEFF Research Database (Denmark)

    Sørensen, Carsten Steen; Clausen, Carl J. Frimann; Andersen, Henrik

    1993-01-01

    This paper presents a comparison between different methods of bearing capacity analyses: Upper Bound Method. Limit Equilibrium Analysis and Finite Element Analysis. For the Great Belt East Bridge anchor blocks it was concluded that these methods of calculation agree within 5%. However, for cases...

  20. Linking self and ingroup : Self-anchoring as distinctive cognitive route to social identification

    NARCIS (Netherlands)

    van Veelen, Ruth; Otten, Sabine; Hansen, Nina

    2011-01-01

    The present paper investigates how cognitive projection processes instigate social identification. We complement the classical self-stereotyping approach (i.e., conforming to prototypical group norms) by investigating self-anchoring (i.e., projection from self to group) as a distinct cognitive route

  1. Hearing rehabilitation in Treacher Collins Syndrome with bone anchored hearing aid

    Directory of Open Access Journals (Sweden)

    José Fernando Polanski

    2015-12-01

    Full Text Available Objective: To describe a case of hearing rehabilitation with bone anchored hearing aid in a patient with Treacher Collins syndrome. Case description: 3 years old patient, male, with Treacher Collins syndrome and severe complications due to the syndrome, mostly related to the upper airway and hearing. He had bilateral atresia of external auditory canals, and malformation of the pinna. The initial hearing rehabilitation was with bone vibration arch, but there was poor acceptance due the discomfort caused by skull compression. It was prescribed a model of bone-anchored hearing aid, in soft band format. The results were evaluated through behavioral hearing tests and questionnaires Meaningful Use of Speech Scale (MUSS and Infant-Toddler Meaningful Auditory Integration Scale (IT-MAIS. Comments: The patient had a higher acceptance of the bone-anchored hearing aid compared to the traditional bone vibration arch. Audiological tests and the speech and auditory skills assessments also showed better communication and hearing outcomes. The bone-anchored hearing aid is a good option in hearing rehabilitation in this syndrome.

  2. Phospholipase D specific for the phosphatidylinositol anchor of cell-surface proteins is abundant in plasma

    International Nuclear Information System (INIS)

    An enzyme activity capable of degrading the glycosyl-phosphatidylinositol membrane anchor of cell-surface proteins has previously been reported in a number of mammalian tissues. The experiments reported here demonstrate that this anchor-degrading activity is also abundant in mammalian plasma. The activity was inhibited by EGTA or 1,10-phenanthroline. It was capable of removing the anchor from alkaline phosphatase, 5'-nucleotidase, and variant surface glycoprotein but had little or no activity toward phosphatidylinositol or phosphatidylcholine. Phosphatidic acid was the only 3H-labeled product when this enzyme hydrolyzed [3H]myristate-labeled variant surface glycoprotein. It could be distinguished from the Ca2=-dependent inositol phospholipid-specific phospholipase C activity in several rat tissues on the basis of its molecular size and its sensitivity to 1,10-phenanthroline. The data therefore suggest that this activity is due to a phospholipase D with specificity for glycosylphosphatidylinositol structures. Although the precise physiological function of this anchor-specific phospholipase D remains to be determined, these findings indicate that it could play an important role in regulating the expression and release of cell-surface proteins in vivo

  3. Parameter analysis of anchor bolt support for large-span and jointed rock mass

    Institute of Scientific and Technical Information of China (English)

    LI Xi-bing; ZHOU Zi-long; LI Qi-yue; HU Liu-qing

    2005-01-01

    In order to obtain the optimal parameters of anchor bolt supporting system for large-span and jointed rock mass in Kaiyang Phosphor Mine, it is expensive and unavailable with the method of in-situ experiments. This paper describes a numerical modeling with discrete element method for the supporting effects of different type of anchor bolts. The anchor bolts with variant length of 0.5 m, 0.8 m, 1.0 m, diameter of 10 mm, 15 mm, 20 mm, setting spacing of 3.0 m, 2.5 m, 2.0 m, and setting angle of 10°, 20°, 30°, are simulated respectively. The results show that there exist optimal parameters of anchor bolt support for large-span and jointed rock mass. For the bolt support of the concerning, the optimal length is 2.5-3.5 m, the diameter is 25-35 mm, the spacing is 0.5-0.6 m, and the setting angle is 105°.

  4. The Study of Collective Actions in a University Anchored Community Wireless Network

    Science.gov (United States)

    Kuchibhotla, Hari N.

    2012-01-01

    The emergence of wireless devices and the ease in setting up wireless devices has created opportunities for various entities, and in particular to universities, by partnering with their local communities in the form of a university anchored community wireless network. This provides opportunities for students to be part of the community-based…

  5. Distinct Pathways Mediate the Sorting of Tail-anchored Mitochondrial Outer Membrane Proteins

    Science.gov (United States)

    Little is known about the biogenesis of tail-anchored (TA) proteins localized to the mitochondrial outer membrane in plant cells. To address this issue, we screened all of the (>600) known and predicted TA proteins in Arabidopsis thaliana for those annotated, based on Gene Ontology, to possess mitoc...

  6. Hearing rehabilitation in Treacher Collins Syndrome with bone anchored hearing aid

    Science.gov (United States)

    Polanski, José Fernando; Plawiak, Anna Clara; Ribas, Angela

    2015-01-01

    Objective: To describe a case of hearing rehabilitation with bone anchored hearing aid in a patient with Treacher Collins syndrome. Case description: 3 years old patient, male, with Treacher Collins syndrome and severe complications due to the syndrome, mostly related to the upper airway and hearing. He had bilateral atresia of external auditory canals, and malformation of the pinna. The initial hearing rehabilitation was with bone vibration arch, but there was poor acceptance due the discomfort caused by skull compression. It was prescribed a model of bone-anchored hearing aid, in soft band format. The results were evaluated through behavioral hearing tests and questionnaires Meaningful Use of Speech Scale (MUSS) and Infant-Toddler Meaningful Auditory Integration Scale (IT-MAIS). Comments: The patient had a higher acceptance of the bone-anchored hearing aid compared to the traditional bone vibration arch. Audiological tests and the speech and auditory skills assessments also showed better communication and hearing outcomes. The bone-anchored hearing aid is a good option in hearing rehabilitation in this syndrome. PMID:26298651

  7. Dynamic calculation model and seismic response for frame supporting structure with prestressed anchors

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    A dynamic calculation model of frame supporting structures with prestressed anchors for the slope stability is proposed. The frame and soil are closely contacted in the role of prestressed anchors and they cannot be separated along the whole slope. The lateral displacement of frame and soil is nearly in phase. The movement characteristic satisfies the theory of elastic foundation beam. The frame is treated with elastic foundation beam in this model. The influence of prestressed anchors is simplified as linear spring and damped system related with velocity. Under the condition of horizontal earthquake excitation, the equation of vibration response is established by using the model of dynamic Winkler beam and the analytical solutions are obtained for simple harmonic vibration. This method is applied to a case record for illustration of its capability, in order to verify the method, 3D nonlinear FEM (ADINA) is used to analyze the seismic performance of this case, the comparative results show that the design and the analysis are safe and credible by using the proposed method. The calculation model provides a new way for earthquake analysis and seismic design of slope stability supported by frame structure with prestressed anchors.

  8. Decay accelerating factor (DAF) is anchored to membranes by a C-terminal glycolipid

    International Nuclear Information System (INIS)

    Purified 70 kDa membrane (m) DAF incorporates into cells when added in vitro. A 2 kDa smaller DAF form which functions extrinsically like C4bp but is unable to incorporate can be isolated from urine (u). Because of common deficits of mDAF and acetylcholinesterase (AChE) in erythrocytes (E) of patients with paroxysmal nocturnal hemoglobinuria (PNH), mDAF was analyzed for a O-terminal glycolipid membrane anchor similar to that in E AChE. Incubation of E with phosphatidylinositol-specific phospholipase C, an enzyme which cleaves a similar glycolipid anchor in trypanosome variant surface glycoproteins (mfVSGs), released 20% of the DAF antigen. The released DAF species resembled uDAF in size, extrinsic model of C4b2a decay, and lack of hydrophobicity. Reductive radiomethylation of mDAF with [14C]HCHO and NaCNBH3 revealed ethanolamine and glucosamine in proportions similar to those in the E AChE glycolipid anchor. Papain cleavage of radiomethylated mDAF released the labeled ethanolamine and glucosamine in small O-terminal fragments from the residual DAF that retained N-terminal Asp. Following labeling of the anchors of mDAF and E AChE with the lipophilic photoreagent 3-trifluoromethyl-3-(m-[125I]iodophenyl)diazirine, cleavage at the glucosamine residue by deamination quantitatively released the label from both proteins. Biosynthetic labeling of Hela cells with [3H]ethanolamine resulted in rapid 3H incorporation into both 48 kDa proDAF and 70 kDa mDAF. These data indicate that mDAF is anchored by a glycolipid similar to that in E AChE, mfVSGs and Thy-1 antigen and raise the possibility that a defect in the assembly or attachment of this structure could account for the deficits of mDAF and E AChE in PNH

  9. A deformable generic 3D model of haptoral anchor of Monogenean.

    Directory of Open Access Journals (Sweden)

    Bee Guan Teo

    Full Text Available In this paper, a digital 3D model which allows for visualisation in three dimensions and interactive manipulation is explored as a tool to help us understand the structural morphology and elucidate the functions of morphological structures of fragile microorganisms which defy live studies. We developed a deformable generic 3D model of haptoral anchor of dactylogyridean monogeneans that can subsequently be deformed into different desired anchor shapes by using direct manipulation deformation technique. We used point primitives to construct the rectangular building blocks to develop our deformable 3D model. Point primitives are manually marked on a 2D illustration of an anchor on a Cartesian graph paper and a set of Cartesian coordinates for each point primitive is manually extracted from the graph paper. A Python script is then written in Blender to construct 3D rectangular building blocks based on the Cartesian coordinates. The rectangular building blocks are stacked on top or by the side of each other following their respective Cartesian coordinates of point primitive. More point primitives are added at the sites in the 3D model where more structural variations are likely to occur, in order to generate complex anchor structures. We used Catmull-Clark subdivision surface modifier to smoothen the surface and edge of the generic 3D model to obtain a smoother and more natural 3D shape and antialiasing option to reduce the jagged edges of the 3D model. This deformable generic 3D model can be deformed into different desired 3D anchor shapes through direct manipulation deformation technique by aligning the vertices (pilot points of the newly developed deformable generic 3D model onto the 2D illustrations of the desired shapes and moving the vertices until the desire 3D shapes are formed. In this generic 3D model all the vertices present are deployed for displacement during deformation.

  10. Walls shielding against ionizing radiation

    International Nuclear Information System (INIS)

    These specifications are to help the users of lead bricks as under DIN 25407, leaf 1, with the construction of walls shielding against ionizing radiation by examples for the uses of the different types of lead bricks and by recommendations for the construction of shielding walls and for the determination of the wall thickness necessary for shielding against γ-radiation as a function of energy. (orig./AK)

  11. Dynamics of monopole walls

    Energy Technology Data Exchange (ETDEWEB)

    Maldonado, R., E-mail: rafael.maldonado@durham.ac.uk; Ward, R.S., E-mail: richard.ward@durham.ac.uk

    2014-06-27

    The moduli space of centred Bogomolny–Prasad–Sommerfield 2-monopole fields is a 4-dimensional manifold M with a natural metric, and the geodesics on M correspond to slow-motion monopole dynamics. The best-known case is that of monopoles on R{sup 3}, where M is the Atiyah–Hitchin space. More recently, the case of monopoles periodic in one direction (monopole chains) was studied a few years ago. Our aim in this note is to investigate M for doubly-periodic fields, which may be visualized as monopole walls. We identify some of the geodesics on M as fixed-point sets of discrete symmetries, and interpret these in terms of monopole scattering and bound orbits, concentrating on novel features that arise as a consequence of the periodicity.

  12. Dynamics of monopole walls

    International Nuclear Information System (INIS)

    The moduli space of centred Bogomolny–Prasad–Sommerfield 2-monopole fields is a 4-dimensional manifold M with a natural metric, and the geodesics on M correspond to slow-motion monopole dynamics. The best-known case is that of monopoles on R3, where M is the Atiyah–Hitchin space. More recently, the case of monopoles periodic in one direction (monopole chains) was studied a few years ago. Our aim in this note is to investigate M for doubly-periodic fields, which may be visualized as monopole walls. We identify some of the geodesics on M as fixed-point sets of discrete symmetries, and interpret these in terms of monopole scattering and bound orbits, concentrating on novel features that arise as a consequence of the periodicity

  13. Dynamics of monopole walls

    CERN Document Server

    Maldonado, R

    2014-01-01

    The moduli space of centred Bogomolny-Prasad-Sommmerfield 2-monopole fields is a 4-dimensional manifold M with a natural metric, and the geodesics on M correspond to slow-motion monopole dynamics. The best-known case is that of monopoles on R^3, where M is the Atiyah-Hitchin space. More recently, the case of monopoles periodic in one direction (monopole chains) was studied a few years ago. Our aim in this note is to investigate M for doubly-periodic fields, which may be visualized as monopole walls. We identify some of the geodesics on M as fixed-point sets of discrete symmetries, and interpret these in terms of monopole scattering and bound orbits, concentrating on novel features that arise as a consequence of the periodicity.

  14. Great Wall of China

    Science.gov (United States)

    2001-01-01

    This ASTER sub-image covers a 12 x 12 km area in northern Shanxi Province, China, and was acquired January 9, 2001. The low sun angle, and light snow cover highlight a section of the Great Wall, visible as a black line running diagonally through the image from lower left to upper right. The Great Wall is over 2000 years old and was built over a period of 1000 years. Stretching 4500 miles from Korea to the Gobi Desert it was first built to protect China from marauders from the north.This image is located at 40.2 degrees north latitude and 112.8 degrees east longitude.Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) is one of five Earth-observing instruments launched December 18, 1999, on NASA's Terra satellite. The instrument was built by Japan's Ministry of International Trade and Industry. A joint U.S./Japan science team is responsible for validation and calibration of the instrument and the data products. Dr. Anne Kahle at NASA's Jet Propulsion Laboratory, Pasadena, Calif., is the U.S. Science team leader; Moshe Pniel of JPL is the project manager. ASTER is the only high resolution imaging sensor on Terra. The primary goal of the ASTER mission is to obtain high-resolution image data in 14 channels over the entire land surface, as well as black and white stereo images. With revisit time of between 4 and 16 days, ASTER will provide the capability for repeat coverage of changing areas on Earth's surface.The broad spectral coverage and high spectral resolution of ASTER will provide scientists in numerous disciplines with critical information for surface mapping, and monitoring dynamic conditions and temporal change. Example applications are: monitoring glacial advances and retreats, monitoring potentially active volcanoes, identifying crop stress, determining cloud morphology and physical properties, wetlands Evaluation, thermal pollution monitoring, coral reef degradation, surface temperature mapping of soils and geology, and measuring surface

  15. Domain wall networks on solitons

    International Nuclear Information System (INIS)

    Domain wall networks on the surface of a soliton are studied in a simple theory. It consists of two complex scalar fields, in 3+1 dimensions, with a global U(1)xZn symmetry, where n>2. Solutions are computed numerically in which one of the fields forms a Q ball and the other field forms a network of domain walls localized on the surface of the Q ball. Examples are presented in which the domain walls lie along the edges of a spherical polyhedron, forming junctions at its vertices. It is explained why only a small restricted class of polyhedra can arise as domain wall networks

  16. Effect of shear connectors on local buckling and composite action in steel concrete composite walls

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Kai, E-mail: kai-zh@purdue.edu [School of Civil Engineering, Purdue University, West Lafayette, IN (United States); Varma, Amit H., E-mail: ahvarma@purdue.edu [School of Civil Engineering, Purdue University, West Lafayette, IN (United States); Malushte, Sanjeev R., E-mail: smalusht@bechtel.com [Bechtel Power Corporation, Frederick, MD (United States); Gallocher, Stewart, E-mail: stewart.gallocher@steelbricks.com [Modular Walling Systems Ltd., Glasgow (United Kingdom)

    2014-04-01

    Steel concrete composite (SC) walls are being used for the third generation nuclear power plants, and also being considered for small modular reactors. SC walls consist of thick concrete walls with exterior steel faceplates serving as reinforcement. These steel faceplates are anchored to the concrete infill using shear connectors, for example, headed steel studs. The steel faceplate thickness (t{sub p}) and yield stress (F{sub y}), and the shear connector spacing (s), stiffness (k{sub s}), and strength (Q{sub n}) determine: (a) the level of composite action between the steel plates and the concrete infill, (b) the development length of steel faceplates, and (c) the local buckling of the steel faceplates. Thus, the shear connectors have a significant influence on the behavior of composite SC walls, and should be designed accordingly. This paper presents the effects of shear connector design on the level of composite action and development length of steel faceplates in SC walls. The maximum steel plate slenderness, i.e., ratio of shear connector spacing-to-plate thickness (s/t{sub p}) ratio to prevent local buckling before yielding is also developed based on the existing experimental database and additional numerical analysis.

  17. Effect of shear connectors on local buckling and composite action in steel concrete composite walls

    International Nuclear Information System (INIS)

    Steel concrete composite (SC) walls are being used for the third generation nuclear power plants, and also being considered for small modular reactors. SC walls consist of thick concrete walls with exterior steel faceplates serving as reinforcement. These steel faceplates are anchored to the concrete infill using shear connectors, for example, headed steel studs. The steel faceplate thickness (tp) and yield stress (Fy), and the shear connector spacing (s), stiffness (ks), and strength (Qn) determine: (a) the level of composite action between the steel plates and the concrete infill, (b) the development length of steel faceplates, and (c) the local buckling of the steel faceplates. Thus, the shear connectors have a significant influence on the behavior of composite SC walls, and should be designed accordingly. This paper presents the effects of shear connector design on the level of composite action and development length of steel faceplates in SC walls. The maximum steel plate slenderness, i.e., ratio of shear connector spacing-to-plate thickness (s/tp) ratio to prevent local buckling before yielding is also developed based on the existing experimental database and additional numerical analysis

  18. Morphometric quantification of biodegradable PLDLLA-anchor implant-beds on magnetic resonance images of the humeral head

    International Nuclear Information System (INIS)

    An overview of the functional anatomy of the human shoulder joint is the base for understanding of rotator cuff tears and its surgical repair by means of suture anchors. These anchors, manufactured of biodegradable polymers, do not (or not totally) degrade in the period of time postulated by the manufactures. Bone healing seems to be impaired. Radiological follow-ups of 8 months to years postoperative revealed osteolysis and even cystic deformation of the implant beds (=anchor-holes). In this present study the anchor-holes are morphometrically measured for the first time on MRT-images. For this prospective study MRIs from altogether 38 patients (20 female/18 male, age 43.9a - 81.6a) were selected after arthroscopic rotator cuff repair with 1-4 biodegradable suture anchors (PLDLLA 'Bio-Corkscrews', Arthrex Inc., Naples FL, USA) at a single institution. After signing an informed consent form patients' MRIs could be evaluated after a mean follow-up period of 15.8 and 36 months. The shapes of the bony implant beds were subjectively categorized and for the computer-assisted morphometry of the anchor-hole areas Adobe Photoshop; CS3 Extended (Version 10.0) was used and adapted. The results were statistically analyzed and correlated with the clinical success rate (Constant Score=CS). All anchor-holes were discernable for up to 42 months. A significant shift of threaded to cylindric anchor-hole shapes was evident from the 1st to 2nd follow-up. Only 11.5% of the anchor-holes showed a cystic enlargement. At the 1st follow-up the anchor-hole areas increased on average by 50.87% compared to original anchor size. However, at the 2nd follow-up all anchor-hole areas decreased significantly (pst follow-up. The average preoperative CS improved from 38.5 points to 87.4 (1st follow-up) and then remained at 87 points (2nd follow-up). Anchor-holes of biodegradable suture anchor are, as opposed to the time period claimed by the manufacturers, visible and thus not totally degraded for up

  19. Effect of the hydroaffinity and topology of pore walls on the structure and dynamics of confined water

    Energy Technology Data Exchange (ETDEWEB)

    Harrach, Michael F., E-mail: harrach@fkp.tu-darmstadt.de; Klameth, Felix; Drossel, Barbara; Vogel, Michael, E-mail: michael.vogel@physik.tu-darmstadt.de [Institut für Festkörperphysik, Technische Universität Darmstadt, Hochschulstr. 6, 64289 Darmstadt (Germany)

    2015-01-21

    We perform molecular dynamics simulations to observe the structure and dynamics of SPC/E water in amorphous silica pores and amorphous ice pores with radii slightly larger than 10 Å. In addition to atomically rough pores, we construct completely smooth pores such that the potential felt at a given distance from the pore wall is an averaged atomic potential. As compared to rough walls, smooth walls induce stronger distortions of water structure for both silica and ice confinements. On the other hand, unlike the smooth pores, the rough pores strongly slow down water dynamics at the pore wall. The slowdown vanishes when reducing the atomic charges in the wall, i.e., when varying the hydroaffinity, while keeping the surface topology, indicating that it is not a geometric effect. Rather, it is due to the fact that the wall atoms provide a static energy landscape along the surface, e.g., fixed anchor-points for hydrogen bonds, to which the water molecules need to adapt, blocking channels for structural rearrangement. In the smooth pores, water dynamics can be faster than in the bulk liquid not only at the pore wall but also in the pore center. Changes in the tetrahedral order rather than in the local density are identified as the main cause for this change of the dynamical behavior in the center of smooth pores.

  20. Moisture Research - Optimizing Wall Assemblies

    Energy Technology Data Exchange (ETDEWEB)

    Arena, L.; Mantha, P.

    2013-05-01

    The Consortium for Advanced Residential Buildings (CARB) evaluated several different configurations of wall assemblies to determine the accuracy of moisture modeling and make recommendations to ensure durable, efficient assemblies. WUFI and THERM were used to model the hygrothermal and heat transfer characteristics of these walls.

  1. Triple labrum tears repaired with the JuggerKnot™ soft anchor: Technique and results

    Directory of Open Access Journals (Sweden)

    Vivek Agrawal

    2015-01-01

    Full Text Available Purpose: The 2-year outcomes of patients undergoing repair of triple labrum tears using an all-suture anchor device were assessed. Materials and Methods: Eighteen patients (17 male, one female; mean age 36.4 years, range: 14.2-62.3 years with triple labrum tears underwent arthroscopic repair using the 1.4 mm JuggerKnot Soft Anchor (mean number of anchors 11.5, range: 9-19 anchors. Five patients had prior surgeries performed on their operative shoulder. Patients were followed for a mean of 2.0 years (range: 1.6-3.0 years. Constant-Murley shoulder score (CS and Flexilevel scale of shoulder function (FLEX-SF scores were measured, with preoperative and final postoperative mean scores compared with a paired Student′s t-test (P < 0.05. Magnetic resonance imaging (MRI was also performed at final postoperative. Results: Overall total CS and FLEX-SF scores increased from 52.9 ± 20.4 to 84.3 ± 10.7 (P < 0.0001 and from 29.3 ± 4.7 to 42.0 ± 7.3 (P < 0.0001, respectively. When divided into two groups by whether or not glenohumeral arthrosis was present at the time of surgery (n = 9 each group, significant improvements in CS and FLEX-SF were obtained for both groups (P < 0.0015. There were no intraoperative complications. All patients, including contact athletes, returned to their preinjury level of sports activity and were satisfied. MRI evaluation revealed no instances of subchondral cyst formation or tunnel expansion. Anchor tracts appeared to heal with fibrous tissue, complete bony healing, or combined fibro-osseous healing. Conclusion: Our results are encouraging, demonstrating a consistent healing of the anchor tunnels through arthroscopic treatment of complex labrum lesions with a completely suture-based implant. It further demonstrates a meaningful improvement in patient outcomes, a predictable return to activity, and a high rate of patient satisfaction. Level of Evidence: Level IV case series.

  2. Multi-dimensional Likelihood Estimation Techniques in conjunction with the Method of Anchored Distributions (MAD)

    Science.gov (United States)

    Over, M. W.; Murakami, H.; Hahn, M. S.; Yang, Y.; Rubin, Y.

    2010-12-01

    The method of anchored distributions (MAD, Rubin et al., Water Resour. Res., 2010) is a Bayesian inversion technique that combines geostatistical concepts with a strategy for localization of data that is indirectly related to the target variables, using anchors. Anchors are statistical distributions of the target variables (e.g., the hydraulic conductivity) at specific locations The variable field is described by the statistical distributions of structural parameters that characterize global features and by anchor distributions that intend to capture local effects. The posterior distributions of structural and anchor parameter sets are used to update the approximate spatial distribution of target variable and are generated by re-sampling the parameter sets using their normalized likelihood estimates as the probability of being selected. Increasing the dimension of the data, to include additional information in the likelihood estimate, increases the computational burden. Two measures are taken to accommodate the advantageous additional data without spurious side effects. (1) Partitioning parameter sets into hypercubes, based upon the similarity of the structural parameter values. (2) Principal component analysis, to reduce the dimensionality by discarding a certain percentage of principal components. As an additional feature for large sample sets, or faster calculation, a ‘bundling’ regime can be implemented. Bundling is employed immediately after partitioning the parameter sets into hypercubes. Bundling identifies spatial patterns amongst the realizations generated from the distributions defining the anchor parameters. The added organizational step allows data with reduced sample sizes to be passed to the PCA algorithm. The division of the data set allows for simple parallelization of the computation and our case study achieved a three-fold dimension reduction. Because of the high dimension involved in the calculation, without absurdly large sample sizes, it is

  3. Constructive and problem-based learning using blended learning anchored instruction approaches

    Science.gov (United States)

    Mayer, M.

    2012-04-01

    Based on an anchored instruction approach, an enriched blended learning lecture course ("Introduction into GNSS positioning") was established in order to enable constructive and problem-based learning. The lecture course "Introduction into GNSS positioning" is a compulsory part of the Bachelor study course "Geodesy and Geoinformatics" and also a supplementary module of the Bachelor study course "Geophysics". Within the lecture course, basic knowledge and basic principles of Global Navigation Satellite Systems, like GPS, are imparted. The presented higher education technique "anchored instruction" uses a real and up-to-date and therefore authentic scientific paper dealing with a recent large-scale geodetic project (Fehmarn Belt Fixed Link) in order to introduce the topic of GNSS-based positioning to the students. In the beginning of the semester, the students have to read the paper individually and carefully. This enables them to realize a lot of not-known GNSS-related facts. Therefore, questions can be formulated focusing on new, unclear or not-understood aspects of the paper. The lecture course deals with these questions, in order to answer them throughout the semester. During the lecture course this paper is referred, e.g., in the middle of the semester, the paper has to be read again in order to check which questions have been answered; in addition, new question arise. At the end of the lecture course, the author of the scientific paper gave a concluding lecture. The framing anchor technique enables the students to anchor their GNSS knowledge. The presented case study uses a teaching resp. learning setting consisting of classroom lectures (given by teachers and learners), practical trainings (e.g., field exercises, students select topics individually), and online lectures (learning management system ILIAS is used as data, result, and asynchronous communication platform). The implementation and the elements of the anchoring technique, which enables student

  4. The utilisation of a career conversation framework based on Schein’s career anchors model

    Directory of Open Access Journals (Sweden)

    Magda Bezuidenhout

    2013-01-01

    Full Text Available Orientation: This  study  constituted  and  reported  on  the  outcomes  of  a  structured  career conversation  framework  based  on  Schein’s  eight  career  anchors  in  an  open  distance  and e-learning (ODeL university in South Africa.Research purpose: The purpose of the research was to report on the utilisation of a structured career conversation framework based on Schein’s career anchors model.Motivation for the study: The rationale for the study was the paucity of studies investigating career anchors in South Africa’s multicultural organisational context.Research design, approach and method: A quantitative approach was adopted in the study. The population consisted of 4200 employees at a university in South Africa. Statistical analysis was performed using one-way analysis of variance (ANOVA as well as a Scheffe post hoc test.Main  findings: The  findings  of  this  study  suggest  that  career  conversation  has  a  dynamic nature (i.e. it changes over a period of time. Consequently, career development interventions in the workplace need to approach the workforce holistically.Practical/managerial implications: The findings and results will assist managers, practitioners and  career  development  specialists  in  the  practical  implementation  of  the  career  anchor concept.Contribution/value-add: The career conversation framework based on Schein’s career anchors has expanded the existing theory to find the right balance between career conversations and career anchors to keep people motivated to perform optimally in an organisation.

  5. High-affinity binding of short peptides to major histocompatibility complex class II molecules by anchor combinations.

    OpenAIRE

    Hammer, J.; Belunis, C; Bolin, D; Papadopoulos, J.; Walsky, R; Higelin, J; Danho, W; Sinigaglia, F; Nagy, Z A

    1994-01-01

    We have previously identified four anchor positions in HLA-DRB1*0101-binding peptides, and three anchors involved in peptide binding to DRB1*0401 and DRB1*1101 molecules, by screening of an M13 peptide display library (approximately 20 million independent nonapeptides) for DR-binding activity. In this study, high stringency screening of the M13 library for DRB1*0401 binding has resulted in identification of three further anchor positions. Taken together, a peptide-binding motif has been obtai...

  6. Dry wall Kras 2011

    Directory of Open Access Journals (Sweden)

    Domen Zupančič

    2012-01-01

    Full Text Available Despite the modesty of hiska, they show a simple understanding of corbelling technique. One could say they are all examples of human landscape cultivation. Although there is no evident common line when comparing all types of hiska, the cunning eye may observe one shared feature: the positioning of the entrance. More or less all the documented shelters have south or south-western facing entrances. The burja is a cold northerly wind; from the south (Adriatic Sea the winds are warmer. When resting, the setting sun is taken as a sign of the ending of the working day and a reward for the whole day’s efforts. Entrances are the only openings to these structures, and they should serve as well as possible - to watch over the crops, to wait when hunting, to enjoy the calm of evening light, to breathe the sea wind.The syntax of the architectural language of layering stone and shaping the pattern of the landscape remain an inventive realisation of spatial ideas from the past until today. Not only ideas of shaping space - these ideas are basic interventions in the natural habitat which contribute to survival. Culture and an awareness of its values are the origins of local development and reasonable heritage preservation. The next step are tutorial days with workshops on how to build dry stone structures, walls and other stone architecture, as the DSWA organisation in the UK is doing.

  7. Pharmacy without walls.

    Science.gov (United States)

    Shane, R R

    1996-02-15

    Attributes of excellence in pharmacy management are described: big-picture thinking, the ability to exploit change, and willingness to take risks. Big-picture thinking means understanding trends that are shaping health care in order to determine where pharmacy fits. Health systems look beyond inpatient care and use case managers to maximize resource use; pharmacists might serve as case managers. Managed care has caused physicians to be more receptive to resource-management strategies, such as clinical pathways; pharmacists can collaborate in the development of clinical pathways. Pharmacists can serve as physician extenders; for example, by conducting anticoagulation or hypertension clinics. Pharmacists need flexibility to adapt to changes in the internal organization of acute care institutions; they will need to learn about the clinical, behavioral, operational, and fiscal aspects of managing the total patient. New reporting relationships give pharmacists the opportunity to demonstrate to other members of the health care team their role in preventing, managing, and resolving drug-related problems throughout the continuum of care. Risk-taking can mean setting ambitious goals. By setting and achieving ambitious goals for products and services, pharmacists can raise patients' and other health care providers' expectations for pharmacy services. Pharmacists' success will depend on their willingness to experiment with new services and discard services that do not substantially advance patient care. Pharmacists must monitor changes in the provision of health care, determine the implications for their practice and seek opportunities for participation outside the walls within which they have traditionally practiced. PMID:8673664

  8. Application of the Expansion Anchor Bolt and the Chemical Anchor to the Stair Lift%膨胀螺栓和化学锚栓在楼梯升降机中的应用

    Institute of Scientific and Technical Information of China (English)

    蔡祖光; 万海如

    2012-01-01

    This paper introduces the construction,principle,failure way, design and selection,installation quality and the evaluation for the expansion anchor bolt and the chemical anchor, and discusses key points of the stair lift installation with the expansion anchor bolt and the chemical anchor in detail.%介绍了膨胀螺栓和化学锚栓的结构、工作机理、失效方式、设计选用、安装质量及其评定方法,详细讨论了楼梯升降机安装施工中使用膨胀螺栓和化学螺栓时应注意的问题。

  9. Webtag: a new web tool providing tags/anchors for RT-PCR experiments with prokaryotes

    Directory of Open Access Journals (Sweden)

    Lindblad Peter

    2007-10-01

    Full Text Available Abstract Background Webtag is a tool providing oligonucleotide sequences (usually called tags or anchors that are absent from a specified genome. These tags/anchors can be appended to gene specific primers for reverse transcriptase polymerase chain reaction experiments, circumventing genomic DNA contamination. Results The use of a relational database, in conjunction with a series of scripts written in PHP and Perl, allows the user to rapidly obtain tags that are: 1 suitable for a specific organism, and 2 compatible with other oligonucleotides to be used in the experimental procedures. Conclusion This new web tool allows scientists to easily and rapidly obtain suitable tags for RT-PCR experiments, and is available at http://www.egs.uu.se/software/webtag/.

  10. Communication: Electrical rectification of C59N: The role of anchoring and doping sites

    International Nuclear Information System (INIS)

    Based on the nonequilibrium Green’s function formalism and density-functional theory, we investigate the onset of electrical rectification in a single C59N molecule in conjunction with gold electrodes. Our calculations reveal that rectification is dependent upon the anchoring of the Au atom on C59N; when the Au electrode is singly bonded to a C atom (labeled here as A), the system does not exhibit rectification, whereas when the electrode is connected to the C–C bridge site between two hexagonal rings (labeled here as B), transmission asymmetry is observed, where the rectification ratio reaches up to 2.62 at ±1 V depending on the N doping site relative to the anchoring site. Our analysis of the transmission mechanism shows that N doping of the B configuration causes rectification because more transmission channels are available for transmission in the B configuration than in the A configuration

  11. Communication: Electrical rectification of C{sub 59}N: The role of anchoring and doping sites

    Energy Technology Data Exchange (ETDEWEB)

    Tawfik, Sherif Abdulkader, E-mail: sherif.abbas@sydney.edu.au; Stampfl, C. [School of Physics, The University of Sydney, Sydney, New South Wales 2006 (Australia); Cui, X. Y.; Ringer, S. P. [Australian Centre for Microscopy and Microanalysis, and School of Aerospace, Mechanical and Mechatronic Engineering, The University of Sydney, Sydney, New South Wales 2006 (Australia)

    2016-01-14

    Based on the nonequilibrium Green’s function formalism and density-functional theory, we investigate the onset of electrical rectification in a single C{sub 59}N molecule in conjunction with gold electrodes. Our calculations reveal that rectification is dependent upon the anchoring of the Au atom on C{sub 59}N; when the Au electrode is singly bonded to a C atom (labeled here as A), the system does not exhibit rectification, whereas when the electrode is connected to the C–C bridge site between two hexagonal rings (labeled here as B), transmission asymmetry is observed, where the rectification ratio reaches up to 2.62 at ±1 V depending on the N doping site relative to the anchoring site. Our analysis of the transmission mechanism shows that N doping of the B configuration causes rectification because more transmission channels are available for transmission in the B configuration than in the A configuration.

  12. The Effect of Colour on the Anchoring Heuristic in Consumer Decision Making

    Directory of Open Access Journals (Sweden)

    Sungwon Han

    2014-08-01

    Full Text Available The purpose of our research was to investigate the effect of colour on cognitive processing styles in social decision-making situations. The present research investigated the effect of colour on estimating the price of a gift for a social target. Two colours, blue and red, were provided as environmental cues, and the motivation for a decision was manipulated, by varying the target person’s level of attractiveness in a presentation slide during a gift-purchasing simulation. A blue background with low motivation resulted in the anchoring effect, meaning that participants used heuristic processing. However, for a blue background with high motivation and red backgrounds with both high and low motivational levels, participants were not influenced by any anchoring effect. The results indicated that the effect of colour on cognitive style interacted with the motivational level, the attractiveness of the photo target. The theoretical implications, evolutionary explanation, and ideas for further research are also discussed.

  13. Multiwalled carbon nanotubes anchored with maghemite nanocrystals for high-performance lithium storage

    International Nuclear Information System (INIS)

    Highlights: • γ-Fe2O3 nanocrystals uniformly anchored on MWCNT via facile layer-by-layer technique. • The hybrid exhibits enhanced structural stability and charge transport capability. • Superior lithium storage performance by virtue of unique structural characteristics. - Abstract: In this paper, we have anchored maghemite (γ-Fe2O3) nanocrystals compactly and uniformly on multiwalled carbon nanotubes (MWCNT) via a polyelectrolyte-assisted layer-by-layer assembly approach based on electrostatic attraction. When evaluated as an anode for lithium-ion batteries (LIBs), the as-synthesized MWCNT-γ-Fe2O3 nanohybrid displays high reversible capacities, remarkable cycling stability, and magnificent high rate capability, facilitating its application as an advanced anode for high-energy, long-life, and high-power LIBs

  14. Note on the hydrodynamic description of thin nematic films: strong anchoring model

    CERN Document Server

    Lin, Te-Sheng; Archer, Andrew J; Kondic, Lou; Thiele, Uwe

    2013-01-01

    We discuss the long-wave hydrodynamic model for a thin film of nematic liquid crystal in the limit of strong anchoring at the free surface and at the substrate. Our aim is to clarify how the elastic energy enters the evolution equation for the film thickness; several models exist in the literature that result in qualitatively different behaviour. We consolidate the various approaches and show that the long-wave model derived through an asymptotic expansion of the full nemato-hydrodynamic equations with consistent boundary conditions agrees with the equation one obtains by employing a thermodynamically motivated gradient dynamics formulation based on an underlying free energy functional. As a result, we find that the elastic distortion energy is always stabilising in the case of strong anchoring. To support the discussion in the main part of the paper, an appendix gives the full derivation of the evolution equation for the film thickness via asymptotic expansion.

  15. Focused suggestion with somatic anchoring technique: rapid self-hypnosis for pain management.

    Science.gov (United States)

    Donatone, Brooke

    2013-04-01

    This article details a self-hypnosis technique designed to teach patients how to manage acute or chronic pain through directed focus. The focused suggestion with somatic anchoring technique has been used with various types of pain, including somatic pain (arthritis, post-injury pain from bone breaks, or muscle tears), visceral pain (related to irritable bowel disease), and neuropathic pain (related to multiple sclerosis). This technique combines cognitive restructuring and mindfulness meditation with indirect and direct suggestions during hypnosis. The case examples demonstrate how the focused suggestion with somatic anchoring technique is used with both acute and chronic pain conditions when use of long-term medication has been relatively ineffective. PMID:23724568

  16. Flapping states of an el astically anchored wing in a uniform flow

    CERN Document Server

    Orchini, A; Guerrero, J; Festa, R; Boragno, C

    2012-01-01

    Linear stability analysis of an elastically anchored wing in a uniform flow is investigated both analytically and numerically. The analytical formulation explicitly takes into account the effect of the wake on the wing by means of Theodorsen's theory. Three different parameters non-trivially rule the observed dynamics: mass density ratio between wing and fluid, spring elastic constant and distance between the wing center of mass and the spring anchor point on the wing. We found relationships between these parameters which rule the transition between stable equilibrium and fluttering. The shape of the resulting marginal curve has been successfully verified by high Reynolds number direct numerical simulations. Our findings are of interest in applications related to energy harvesting by fluid-structure interaction, a problem which has recently attracted a great deal of attention. The main aim in that context is to identify the optimal physical/geometrical system configuration leading to large sustained motion, w...

  17. Urokinase-catalysed cleavage of the urokinase receptor requires an intact glycolipid anchor

    DEFF Research Database (Denmark)

    Høyer-Hansen, G; Pessara, U; Holm, A;

    2001-01-01

    reaction, even though the actual cleavage occurs between the first and second domains. Purified full-length GPI-anchored uPAR (GPI-uPAR) proved much more susceptible to uPA-mediated cleavage than recombinant truncated soluble uPAR (suPAR), which lacks the glycolipid anchor. This was not a general...... difference in proteolytic susceptibility since GPI-uPAR and suPAR were cleaved with equal efficiency by plasmin. Since the amino acid sequences of GPI-uPAR and suPAR are identical except for the C-terminal truncation, the different cleavage patterns suggest that the two uPAR variants differ in the......PAR, purified from plasma, was found to have a similar resistance to uPA cleavage as phospholipase C-treated GPI-uPAR and recombinant suPAR....

  18. Palladium nanoparticle anchored polyphosphazene nanotubes: preparation and catalytic activity on aryl coupling reactions

    Indian Academy of Sciences (India)

    V Devi; A Ashok Kumar; S Sankar; K Dinakaran

    2015-06-01

    Highly accessible-supported palladium (Pd) nanoparticles anchored polyphosphazene (PPZ) nanotubes (NTs) having average diameter of 120 nm were synthesized rapidly at room temperature and homogeneously decorated with Pd nanoparticles. The resultant PPZ–Pd nanocomposites were morphologically and structurally characterized by means of transmission electron microscope equipped with energy-dispersive X-ray spectroscopy and X-ray diffraction analysis. Characterization results showed that the Pd nanoparticles with good dispersibility could be well anchored onto the surfaces of the PPZ NTs. The PPZ–Pd NTs show enhanced catalytic activity for the Suzuki coupling of aryl bromides with arylboronic acid. In addition, these PPZ–Pd NTs show excellent behaviour as reusable catalysts of the Suzuki and Heck coupling reactions.

  19. Anchoring energy enhancement and pretilt angle control of liquid crystal alignment on polymerized surfaces

    Science.gov (United States)

    Weng, Libo; Liao, Pei-Chun; Lin, Chen-Chun; Ting, Tien-Lun; Hsu, Wen-Hao; Su, Jenn-Jia; Chien, Liang-Chy

    2015-09-01

    We demonstrate enhanced surface anchoring energy and control of pretilt angle in a nematic liquid crystal cell with vertical alignment and polymerized surfaces (PS-VA). The polymerized surfaces are formed by ultraviolet (UV) irradiation-induced phase separation of a minute amount of a reactive monomer in the vertical-aligned nematic liquid crystal. By introducing a bias voltage during UV curing, surface-localized polymer protrusions with a dimension of 100nm and a field-induced pretilt angle are observed. Experimental evidences and theoretical analyses validate that PS-VA has increased surface anchoring strength by two folds and pretilt angle has been changed from 89° to 86° compared to those of a VA cell. The enabling PS-VA cell technique with excel electro-optical properties such as very good dark state, high optical contrast, and fast rise and decay times may lead to development of a wide range of applications.

  20. Anchoring energy enhancement and pretilt angle control of liquid crystal alignment on polymerized surfaces

    Directory of Open Access Journals (Sweden)

    Libo Weng

    2015-09-01

    Full Text Available We demonstrate enhanced surface anchoring energy and control of pretilt angle in a nematic liquid crystal cell with vertical alignment and polymerized surfaces (PS-VA. The polymerized surfaces are formed by ultraviolet (UV irradiation-induced phase separation of a minute amount of a reactive monomer in the vertical-aligned nematic liquid crystal. By introducing a bias voltage during UV curing, surface-localized polymer protrusions with a dimension of 100nm and a field-induced pretilt angle are observed. Experimental evidences and theoretical analyses validate that PS-VA has increased surface anchoring strength by two folds and pretilt angle has been changed from 89° to 86° compared to those of a VA cell. The enabling PS-VA cell technique with excel electro-optical properties such as very good dark state, high optical contrast, and fast rise and decay times may lead to development of a wide range of applications.

  1. In-plane acoustic reflectors for reducing effective anchor loss in lateral–extensional MEMS resonators

    International Nuclear Information System (INIS)

    In this paper, novel in-plane acoustic reflectors are proposed to enhance the quality factor (Q) in lateral-mode micromachined resonators. Finite element coupled-domain simulation is used to model anchor loss and to estimate the relative change in the resonator's performance without and with the inclusion of acoustic reflectors. Several 27 and 110 MHz AlN-on-silicon resonators are fabricated and measured to validate the theoretical and simulated data. An average Q enhancement of up to 560% is reported for specific designs with reflectors over the same resonators without reflectors. The measured results trend well with the simulated data and support that the acoustic reflectors can reduce the overall anchor loss with minimum modification in the resonator design

  2. Effects of molecule anchoring and dispersion on nanoscopic friction under electrochemical control

    International Nuclear Information System (INIS)

    The application of electric fields is a promising strategy for in situ control of friction. While there have recently been many experimental studies on friction under the influence of electric fields, theoretical understanding is very limited. Recently, we introduced a simple theoretical model for friction under electrochemical conditions that focused on the interaction of a force microscope tip with adsorbed molecules whose orientation was dependent on the applied electric field. Here we focus on the effects of anchoring of the molecules on friction. We show that anchoring affects the intensity and width of the peak in the friction that occurs near a reorientation transition of adsorbed molecules, and explain this by comparing the strength of molecule–molecule and molecule–tip interactions. We derive a dispersion relation for phonons in the layer of adsorbed molecules and demonstrate that it can be used to understand important features of the frictional response. (paper)

  3. Dynamic interaction between the soil and an anchored sheet pile during seismic excitation

    Science.gov (United States)

    Degrande, G.; Praet, E.; van Zegbroeck, B.; van Marcke, P.

    2002-05-01

    A subdomain approach for dynamic soil-structure interaction is proposed for the linear elastic seismic analysis of an anchored sheet pile, retaining a horizontally layered soil on rigid bedrock. A hybrid solution technique is used, employing a finite element formulation for the generalized sheet pile, a thin layer formulation for the soil and a direct stiffness formulation for the tieback; the displacement vectors of the sheet pile and the soil are decomposed, using the eigenmodes of the sheet pile and the propagating or decaying modes in the soil. The discretization can be limited to the interface(s), where pointwise continuity of the displacements is enforced, whereas a weak variational formulation is used for the stress equilibrium. The solution technique is illustrated by means of a numerical example, where the harmonic response of a flexible anchored sheet pile is considered and compared to the case where no tieback is present.

  4. Multiwalled carbon nanotubes anchored with maghemite nanocrystals for high-performance lithium storage

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Ping, E-mail: zjuwuping@njnu.edu.cn; Xie, Kongwei; Xu, Xiali; Li, Jianping; Tang, Yawen; Zhou, Yiming, E-mail: zhouyiming@njnu.edu.cn; Lu, Tianhong

    2015-04-15

    Highlights: • γ-Fe{sub 2}O{sub 3} nanocrystals uniformly anchored on MWCNT via facile layer-by-layer technique. • The hybrid exhibits enhanced structural stability and charge transport capability. • Superior lithium storage performance by virtue of unique structural characteristics. - Abstract: In this paper, we have anchored maghemite (γ-Fe{sub 2}O{sub 3}) nanocrystals compactly and uniformly on multiwalled carbon nanotubes (MWCNT) via a polyelectrolyte-assisted layer-by-layer assembly approach based on electrostatic attraction. When evaluated as an anode for lithium-ion batteries (LIBs), the as-synthesized MWCNT-γ-Fe{sub 2}O{sub 3} nanohybrid displays high reversible capacities, remarkable cycling stability, and magnificent high rate capability, facilitating its application as an advanced anode for high-energy, long-life, and high-power LIBs.

  5. Communication: Electrical rectification of C59N: The role of anchoring and doping sites.

    Science.gov (United States)

    Tawfik, Sherif Abdulkader; Cui, X Y; Ringer, S P; Stampfl, C

    2016-01-14

    Based on the nonequilibrium Green's function formalism and density-functional theory, we investigate the onset of electrical rectification in a single C59N molecule in conjunction with gold electrodes. Our calculations reveal that rectification is dependent upon the anchoring of the Au atom on C59N; when the Au electrode is singly bonded to a C atom (labeled here as A), the system does not exhibit rectification, whereas when the electrode is connected to the C-C bridge site between two hexagonal rings (labeled here as B), transmission asymmetry is observed, where the rectification ratio reaches up to 2.62 at ±1 V depending on the N doping site relative to the anchoring site. Our analysis of the transmission mechanism shows that N doping of the B configuration causes rectification because more transmission channels are available for transmission in the B configuration than in the A configuration. PMID:26772547

  6. Hypothalamus-Anchored Resting Brain Network Changes before and after Sertraline Treatment in Major Depression

    OpenAIRE

    2014-01-01

    Sertraline, one of the oldest antidepressants, remains to be the most efficacious treatment for depression. However, major depression disorder (MDD) is characterized by altered emotion processing and deficits in cognitive control. In cognitive interference tasks, patients with MDD have shown excessive hypothalamus activity. The purpose of this study was to examine the effects of antidepressant treatment (sertraline) on hypothalamus-anchored resting brain circuitry. Functional magnetic resonan...

  7. A-Kinase Anchoring Protein Mediates TRPV1 Thermal Hyperalgesia through PKA Phosphorylation of TRPV1

    OpenAIRE

    Jeske, Nathaniel A.; Diogenes, Anibal; Ruparel, Nikita B.; Fehrenbacher, Jill C.; Henry, Michael; Akopian, Armen N.; Hargreaves, Kenneth M.

    2008-01-01

    Certain phosphorylation events are tightly controlled by scaffolding proteins such as A-Kinase Anchoring Protein (AKAP). On nociceptive terminals, phosphorylation of transient receptor potential channel type 1 (TRPV1) results in the sensitization to many different stimuli, contributing to the development of hyperalgesia. In this study, we investigated the functional involvement of AKAP150 in mediating sensitization of TRPV1, and found that AKAP150 is co-expressed in trigeminal ganglia (TG) ne...

  8. The Effect of the Trabecular Microstructure on the Pullout Strength of Suture Anchors

    OpenAIRE

    Yakacki, Christopher M.; Poukalova, Mariya; Guldberg, Robert E.; Lin, Angela; Saing, Minn; Gillogly, Scott; Gall, Ken

    2010-01-01

    This study investigates how the microstructural properties of trabecular bone affect suture anchor performance. Seven fresh-frozen humeri were tested for pullout strength with a 5 mm Arthrex Corkscrew in the greater tuberosity, lesser tuberosity, and humeral head. Micro-computed tomography analysis was performed in the three regions of interest directly adjacent to individual pullout experiments. The morphometric properties of bone mineral density (BMD), structural model index (SMI), trabecul...

  9. Pullout Strength of Suture Anchors: Effect of Mechanical Properties of Trabecular Bone

    OpenAIRE

    Poukalova, Mariya; Yakacki, Christopher M.; Guldberg, Robert E.; Lin, Angela; Saing, Minn; Gillogly, Scott D.; Gall, Ken

    2010-01-01

    This study investigated the relationships between trabecular microstructure and elastic modulus, compressive strength, and suture anchor pullout strength. Twelve fresh-frozen humeri underwent mechanical testing followed by micro-computed tomography (μCT). Either compression testing of cylindrical bone samples or pullout testing using an Arthrex 5 mm Corkscrew was performed in synthetic sawbone or at specific locations in the humerus such as the greater tuberosity, lesser tuberosity, and humer...

  10. Implantation of a polycaprolactone scaffold with subchondral bone anchoring ameliorates nodules formation and other tissue alterations

    OpenAIRE

    Vikingsson, Line; Sancho-Tello, Mar??a; Ruiz-Saur??, Amparo; Martinez-Diaz, Santos; G??mez-Tejedor, Jos?? Antonio; Gallego Ferrer, Gloria; Carda, Carmen; Monllau Garc??a, Juan Carlos; G??mez Ribelles, Jos?? Luis

    2016-01-01

    PURPOSE: Articular cartilage has limited repair capacity. Two different implant devices for articular cartilage regeneration were tested in vivo in a sheep model to evaluate the effect of subchondral bone anchoring for tissue repair. METHODS: The implants were placed with press-fit technique in a cartilage defect after microfracture surgery in the femoral condyle of the knee joint of the sheep and histologic and mechanical evaluation was done 4.5 months later. The first group consisted of a b...

  11. Lentiviral Engineered Fibroblasts Expressing Codon Optimized COL7A1 Restore Anchoring Fibrils in RDEB

    OpenAIRE

    Georgiadis, Christos,; Syed, Farhatullah; Petrova, Anastasia; Abdul-Wahab, Alya; Lwin, Su M; Farzaneh, Farzin; Chan, Lucas; Ghani, Sumera; Fleck, Roland A.; Glover, Leanne; McMillan, James R.; Chen, Mei; Adrian J Thrasher; McGrath, John A; Di, Wei-Li

    2015-01-01

    Cells therapies, engineered to secrete replacement proteins, are being developed to ameliorate otherwise debilitating diseases. Recessive dystrophic epidermolysis bullosa (RDEB) is caused by defects of type VII collagen (C7), a protein essential for anchoring fibril formation at the dermal-epidermal junction (DEJ). Whilst allogeneic fibroblasts injected directly into the dermis can mediate transient disease modulation, autologous gene-modified fibroblasts should evade immunological rejection ...

  12. Liquid crystal anchoring transitions on aligning substrates processed by plasma beam

    OpenAIRE

    Yaroshchuk, Oleg V.; Kiselev, Alexei D.; Kravchuk, Ruslan M.

    2007-01-01

    We observe a sequence of the anchoring transitions in nematic liquid crystals (NLC) sandwiched between the hydrophobic polyimide substrates treated with the plasma beam. There is a pronounced continuous transition from homeotropic to low tilted (nearly planar) alignment with the easy axis parallel to the incidence plane of the plasma beam (the zenithal transition) that takes place as the exposure dose increases. In NLC with positive dielectric anisotropy, a further increase in the exposure do...

  13. Employees’ work engagement and job commitment: The moderating role of career anchors

    Directory of Open Access Journals (Sweden)

    Melinde Coetzee

    2014-02-01

    Full Text Available Orientation: Organisations continue to focus on human resource initiatives for enhancingemployee commitment, satisfaction and engagement in order to gain a competitive edge in adynamic and fast-changing marketplace.Research purpose: The objective of the present study was to assess whether individuals’career anchors (measured by the career orientations inventory significantly moderate therelationship between their work engagement (measured by the Utrecht work engagementscale and job commitment (measured by the organisation-related commitment scale.Motivation for the study: Although the literature review suggests that people’s workengagement and job commitment may be influenced by their career anchors, there seems to bea paucity of research examining the interaction effects between these three variables.Research approach, design and method: A cross-sectional quantitative survey approach wasused. A non-probability purposive sample of adults (N = 318 employed in a human resourcecapacity in the South African service industry participated in the study. Stepwise hierarchicalmoderated regression analysis was performed to achieve the objective of the study.Main findings: The results showed that the work engagement-job commitment relationshipwas generally stronger for high career anchor preferences than for low career anchorpreferences.Practical/managerial implications: The results of the study can be useful when human resourceinterventions for enhancing employees’ engagement and commitment are developed.Contribution: The results of the study add new insights to the career literature by showing thatpeople’s career self-concepts (as reflected by their career anchors are important to consider inenhancing their work engagement and job commitment.

  14. Employees’ work engagement and job commitment: The moderating role of career anchors

    OpenAIRE

    Melinde Coetzee; Dries Schreuder; Rebecca Tladinyane

    2014-01-01

    Orientation: Organisations continue to focus on human resource initiatives for enhancingemployee commitment, satisfaction and engagement in order to gain a competitive edge in adynamic and fast-changing marketplace.Research purpose: The objective of the present study was to assess whether individuals’career anchors (measured by the career orientations inventory) significantly moderate therelationship between their work engagement (measured by the Utrecht work engagementscale) and job commitme...

  15. Anchoring of organic molecules to a metal surface: HtBDC on Cu(110)

    DEFF Research Database (Denmark)

    Schunack, M.; Petersen, L.; Kuhnle, A.;

    2001-01-01

    The interaction of largish molecules with metal surfaces has been studied by combining the imaging and manipulation capabilities of the scanning tunneling microscope (STM). At the atomic scale, the STM results directly reveal that the adsorption of a largish organic molecule can induce a...... restructuring of a metal surface underneath. This restructuring anchors the molecules on the substrate and is the driving force for a self-assembly process of the molecules into characteristic molecular double rows....

  16. Facial reconstruction with a bone-anchored prosthesis following destructive cancer surgery

    Science.gov (United States)

    MELLO, MONICA C.P.; PIRAS, JOAQUIM AUGUSTO OLIVEIRA; TAKIMOTO, ROBERTO M.; CERVANTES, ONIVALDO; ABRAÃO, MÁRCIO; DIB, LUCIANO L.

    2012-01-01

    Reconstruction of craniofacial defects following cancer surgery may be performed using several techniques and materials. This case report describes surgery for a large tumor, as well as the rehabilitation process which involved a craniofacial prosthesis covering the whole defect of the anterior brain, orbit, mid-face and hard palate. The results suggest that a craniofacial prosthesis anchored on titanium implants is a viable alternative as a retention system, and also a good alternative to other reconstructive surgeries. PMID:23205082

  17. Lipid transfer proteins do their thing anchored at membrane contact sites… but what is their thing?

    Science.gov (United States)

    Wong, Louise H; Levine, Tim P

    2016-04-15

    Membrane contact sites are structures where two organelles come close together to regulate flow of material and information between them. One type of inter-organelle communication is lipid exchange, which must occur for membrane maintenance and in response to environmental and cellular stimuli. Soluble lipid transfer proteins have been extensively studied, but additional families of transfer proteins have been identified that are anchored into membranes by transmembrane helices so that they cannot diffuse through the cytosol to deliver lipids. If such proteins target membrane contact sites they may be major players in lipid metabolism. The eukaryotic family of so-called Lipid transfer proteins Anchored at Membrane contact sites (LAMs) all contain both a sterol-specific lipid transfer domain in the StARkin superfamily (related to StART/Bet_v1), and one or more transmembrane helices anchoring them in the endoplasmic reticulum (ER), making them interesting subjects for study in relation to sterol metabolism. They target a variety of membrane contact sites, including newly described contacts between organelles that were already known to make contact by other means. Lam1-4p target punctate ER-plasma membrane contacts. Lam5p and Lam6p target multiple contacts including a new category: vacuolar non-NVJ cytoplasmic ER (VancE) contacts. These developments confirm previous observations on tubular lipid-binding proteins (TULIPs) that established the importance of membrane anchored proteins for lipid traffic. However, the question remaining to be solved is the most difficult of all: are LAMs transporters, or alternately are they regulators that affect traffic more indirectly? PMID:27068964

  18. Morphometric analysis of treatment effects of bone-anchored maxillary protraction in growing Class III patients

    OpenAIRE

    Baccetti, T.; Clerck, H.J. de; Cevidanes, L. H.; Franchi, L

    2010-01-01

    The aim of the present morphometric investigation was to evaluate the effects of bone-anchored maxillary protraction (BAMP) in the treatment of growing patients with Class III malocclusion. The shape and size changes in the craniofacial configuration of a sample of 26 children with Class III malocclusions consecutively treated with the BAMP protocol were compared with a matched sample of 15 children with untreated Class III malocclusions. All subjects in the two groups were at a prepubertal s...

  19. Fate, complications and MRI implications of retention anchor suture placed during gastrostomy in children

    Energy Technology Data Exchange (ETDEWEB)

    Narayanam, Surendra; De Oliveira, Vicente; Sertic, Madeleine; Connolly, Bairbre L. [The Hospital for Sick Children, Diagnostic Imaging, Division of Image Guided Therapy, Toronto (Canada); Krishnamurthy, Ganesh [The Children' s Hospital of Philadelphia, Department of Radiology, Philadelphia, PA (United States); Bekhit, Elhamy [RCG Melbourne, Medical Imaging, Melbourne (Australia); Cheng, Hai-Ling [The Hospital for Sick Children, Diagnostic Imaging, Toronto (Canada)

    2013-08-15

    Retrograde radiologic gastrostomy is one of several techniques used for placing a gastrostomy and is a common technique used in children. The use of a retention anchor suture (RAS) is an important component of this procedure. This pictorial essay explores the normal course and passage of the RAS, as well as abnormal migration, various complications and the implications of the RAS with regard to MRI safety. (orig.)

  20. The outcome study of arthroscopic repair with anchor suture for anterior shoulder instabilities

    Directory of Open Access Journals (Sweden)

    Guity MR

    2010-10-01

    Full Text Available "nBackground: Anterior glenohumeral instabilities can be corrected with open and arthroscopic surgery. The purpose of this study was to evaluate retrospectively the surgical outcomes of arthroscopic repair of anterior glenohumeral instabilities with use of suture anchors in a series of patients who were followed for twenty to fifty months."n "nMethods: The results of arthroscopic Bankart repair with use of suture anchors in 30 patients with traumatic recurrent anterior instability of the shoulder were evaluated. At the time of follow-up (mean of thirty-three months, the patients were assessed with two outcome measurement tools (the Rowe score, the Constant score. The recurrence rate, range of motion, and risk factors for postoperative recurrence were evaluated."n "nResults: According to the Rowe scale, 12 patients (40% had an excellent score; 13 (43%, a good score; 4 (13%, a fair score; and 1 (4%, a poor score. The mean ROWE score was 81.8 and the mean CONSTANT score was 85.5. Overall, the rate of postoperative recurrence of instability was 10% (two dislocations, one subluxation. The mean delay to recurrence was 20 months. Loss of external rotation in regard to uninvolved extremity was less than 10 degrees in 30% and more than 10 degrees in 10% of patients. The average number of anchors used was 3.2 which follow-up radiographs showed all of them in the osseous glenoid without pullout. In preoperative studies, shoulder 3D CT scan was not performed routinely. Radiographic signs of degenerative changes were noted in one shoulder."n "nConclusion: Arthroscopic capsulolabral repair with use of suture anchors can provide satisfactory outcomes in terms of recurrence rate, activity, and range of motion.

  1. The relationship between perceived own health state and health assessments of anchoring vignettes

    OpenAIRE

    Hinz, Andreas; Häuser, Winfried; Glaesmer, Heide; Brähler, Elmar

    2016-01-01

    Self-reported health depends on the internal frame of reference and on response styles. One way of studying this dependency is using anchoring vignettes. Response shift effects are assumed to induce a negative correlation between self-reported health and the health assessments attributed to the vignettes. Method: A representative sample of the German adult population (N = 2,409) was selected. Participants were asked to rate their health state and the health states of two rather complex vignet...

  2. Decay accelerating factor of complement is anchored to cells by a C-terminal glycolipid

    International Nuclear Information System (INIS)

    Membrane-associated decay accelerating factor (DAF) of human erythrocytes (E/sup hu/) was analyzed for a C-terminal glycolipid anchoring structure. Automated amino acid analysis of DAF following reductive radiomethylation revealed ethanolamine and glucosamine residues in proportions identical with those present in the E/sup hu/ acetylcholinesterase (AChE) anchor. Cleavage of radiomethylated 70-kilodalton (kDa) DAF with papain released the labeled ethanolamine and glucosamine and generated 61- and 55-kDa DAF products that retained all labeled Lys and labeled N-terminal Asp. Incubation of intact E/sup hu/ with phosphatidylinositol-specific phospholipase C (PI-PLC), which cleaves the anchors in trypanosome membrane form variant surface glycoproteins (mfVSGs) and murine thymocyte Thy-1 antigen, released 15% of the cell-associated DAF antigen. The released 67-kDa PI-PLC DAF derivative retained its ability to decay the classical C3 convertase C4b2a but was unable to membrane-incorporate and displayed physicochemical properties similar to urine DAF, a hydrophilic DAF form that can be isolated for urine. Nitrous acid deamination cleavage of E/sup hu/ DAF at glucosamine following labeling with the lipophilic photoreagent 3-(trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine ([125I]TID) released the [125I]TID label in a parallel fashion as from [125I]TID-labeled AChE. Biosynthetic labeling of HeLa cells with [3H] ethanolamine resulted in rapid 3H incorporation into both 48-kDa pro-DAF and 72-kDa mature epithelial cell DAF. The findings indicate that DAF and AChE are anchored in E/sup hu/ by the same or a similar glycolipid structure and that, like VSGs, this structure is incorporated into DAF early in DAF biosynthesis prior to processing of pro-DAF in the Golgi

  3. Taggers versus Linkers: Comparing Tags and Anchor Text of Web Pages

    OpenAIRE

    Liu, Yiming; Kumar, Ruchi; Lim, Kevin

    2008-01-01

    The Web is home to information services that generate vast quantities of content. This presents a tremendous challenge for services that organize this content and facilitate efficient and relevant retrieval. Tagging is one way to organize this information. Tags are short, user-selected keywords and phrases applied to a Web resource, which can serve as concise semantic descriptions of that resource. Hyperlink anchor text appears to serve similar purposes — namely, as user-generated, concise re...

  4. Formation and properties of surface-anchored polymer assemblies with tunable physico-chemical characteristics

    Science.gov (United States)

    Wu, Tao

    We describe two new methodologies leading to the formation of novel surface-anchored polymer assemblies on solid substrates. While the main goal is to understand the fundamentals pertaining to the preparation and properties of the surface-bound polymer assemblies (including neutral and chargeable polymers), several examples also are mentioned throughout the Thesis that point out to practical applications of such structures. The first method is based on generating assemblies comprising anchored polymers with a gradual variation of grafting densities on solid substrates. These structures are prepared by first covering the substrate with a molecular gradient of the polymerization initiator, followed by polymerization from these substrate-bound initiator centers ("grafting from"). We apply this technique to prepare grafting density gradients of poly(acryl amide) (PAAm) and poly(acrylic acid) (PAA) on silica-covered substrates. We show that using the grafting density gradient geometry, the characteristics of surface-anchored polymers in both the low grafting density ("mushroom") regime as well as the high grafting density ("brush") regime can be accessed conveniently on a single sample. We use a battery of experimental methods, including Fourier transform infrared spectroscopy (FTIR), Near-edge absorption fine structure spectroscopy (NEXAFS), contact angle, ellipsometry, to study the characteristics of the surface-bound polymer layers. We also probe the scaling laws of neutral polymer as a function of grafting density, and for weak polyelectrolyte, in addition to the grafting density, we study the affect of solution ionic strength and pH values. In the second novel method, which we coined as "mechanically assisted polymer assembly" (MAPA), we form surface anchored polymers by "grafting from" polymerization initiators deposited on elastic surfaces that have been previously extended uniaxially by a certain length increment, Deltax. Upon releasing the strain in the

  5. Exploring value compasses of leaders in organizations: introducing nine spiritual anchors

    OpenAIRE

    Karakas, Fahri

    2010-01-01

    This article aims to develop an integral framework for analyzing and capturing diverse forms of value compasses of leaders in organizations. Building on the concept of “career anchors” (Schein, Career anchors: discovering your real values, Jossey-Bass Pfeiffer, San Francisco, 1990), the concept of “spiritual anchors” is introduced, patterns of deeply held spiritual motives, values and attitudes that provide direction, meaning, wholeness, and connectedness to a person’s life or work. Based on ...

  6. ARTHROSCOPIC REPAIR OF BANKART’S LESION USING SUTURE ANCHORS IN RECURRENT ANTERIOR SHOULDER INSTABILITY

    OpenAIRE

    Santosh Kumar; Anant Kumar; Sanjay

    2015-01-01

    BACKGROUND : Shoulder instability and its treatment were described even in ancient times by the Greek and Egyptian physicians. Evidence of shoulder dislocation has been found in archaeological and paleopathological examinations of human shoulders several thousand years old. 1 Many techniques have been described in literature for treatment of recurrent shoulder dislocation. Arthroscopic repair of Bankart’s lesion using suture anchors is a noble technique. A sut...

  7. Combining Comprehension Reading Instruction with Video Anchors with Middle Level Learners

    OpenAIRE

    Andreasen, Heidi

    2009-01-01

    Reading comprehension is a multidimensional process and a key component of this process is the activation of prior knowledge in the comprehension of text. This study utilized video clips as a means to anchor instruction and assist struggling middle-level readers in comprehending text. Participants in this study were 17 seventh- and eighth-grade students from a rural middle school. The study used a single-subject reversal design. During the baseline phase of the study, students read four ...

  8. How Buyers Evaluate Product Bundles: A Model of Anchoring and Adjustment.

    OpenAIRE

    Yadav, Manjit S

    1994-01-01

    Bundling, the joint offering of two or more items, is a common selling strategy, yet little research has been conducted on buyers' evaluation of bundle offers. We developed and tested a model of bundle evaluation in which the buyers anchored their evaluation on the item perceived as most important and then made adjustments on the basis of their evaluations of the remaining bundle items. The results of two computerized laboratory experiments suggested that people tend to examine bundle items i...

  9. A glycolipid-anchored prion protein is endocytosed via clathrin-coated pits

    OpenAIRE

    1994-01-01

    The cellular prion protein (PrPc) is a glycolipid-anchored, cell surface protein of unknown function, a posttranslationally modified isoform of which PrPSc is involved in the pathogenesis of Creutzfeldt- Jakob disease, scrapie, and other spongiform encephalopathies. We have shown previously that chPrP, a chicken homologue of mammalian PrPC, constitutively cycles between the cell surface and an endocytic compartment, with a transit time of approximately 60 min in cultured neuroblastoma cells. ...

  10. Hearing rehabilitation in Treacher Collins Syndrome with bone anchored hearing aid

    OpenAIRE

    José Fernando Polanski; Anna Clara Plawiak; Angela Ribas

    2015-01-01

    Objective: To describe a case of hearing rehabilitation with bone anchored hearing aid in a patient with Treacher Collins syndrome. Case description: 3 years old patient, male, with Treacher Collins syndrome and severe complications due to the syndrome, mostly related to the upper airway and hearing. He had bilateral atresia of external auditory canals, and malformation of the pinna. The initial hearing rehabilitation was with bone vibration arch, but there was poor acceptance due the discom...

  11. Is hexamerin receptor a GPI-anchored protein in Achaea janata (Lepidoptera: Noctuidae)?

    Indian Academy of Sciences (India)

    Madhusudhan Budatha; Thuirei Jacob Ningshen; Aparna Dutta-Gupta

    2011-08-01

    The process of uptake of hexamerins during metamorphosis from insect haemolymph by fat body cells is reminiscent of receptor-mediated endocytosis. Previously, we had identified a hexamerin-binding protein (HBP) and reported for the first time that uptake of hexamerins is dependent on the phosphorylation of HBP partly by a tyrosine kinase, which is, in turn, activated by 20-hydroxyecdysone (20E). However, the exact nature of HBP and the mechanism of interaction are still unknown. Here we report the possibility of HBP being a GPI-anchored protein in the fat body of Achaea janata and its role in the tyrosine-kinase-mediated phosphorylation signalling. Digestion of fat body membrane preparation with bacterial phosphatidylinositol-specific phospholipase C (PI-PLC), and the subsequent recognition by antibodies specific for the cross-reacting determinant (CRD), revealed that HBP is glycosylphosphatidylinositol (GPI)-anchored protein and, further, that the hexamerin binding to HBP was inhibited after digestion. Hexamerin overlay assay (HOA) of co-immunoprecipitated in vitro phosphorylated HBP showed exclusive binding to ∼120 kDa protein. Lectin-binding analysis of hexamerins revealed the presence of -acetylgalactosamine (GalNAc) and -acetylglucosamine (GluNAc), whereas HBP showed the presence of GalNac alone. Mild chemical deglycosylation studies and binding interaction in the presence of sugars revealed that glycan moieties are possibly not involved in the interaction between HBP and hexamerins. Taken together, these results suggest that HBP may be a GPI-anchored protein, and interaction and activation of HBP is through lipid-linked non-receptor src tyrosine kinases. However, additional studies are needed to prove that HBP is a GPI-anchored protein.

  12. A Bayesian Examination of Anchoring Bias and Cheap Talk in Contingent Valuation Studies

    OpenAIRE

    Aadland, David; Caplan, Arthur J.; Phillips, Owen R.

    2005-01-01

    We present a theoretical framework for understanding the relationship between anchoring bias, hypothetical bias, and cheap talk in contingent valuation surveys. In our theory, interviewers provide agents with signals such as cheap talk and bid values while eliciting the value for nonmarket goods. In response to these signals, agents revise their prior distributions over the value of the good. Previous empirical studies have failed to account for the interaction between cheap talk and anchorin...

  13. SPECIFIC ASPECTS OF ANCHORING TO BE USED IN FORWARD-LOOKING MARKETING TECHNOLOGIES

    OpenAIRE

    SHKLYAR TATYANA L'VOVNA; PONYAVINA MARIA BORISOVNA

    2015-01-01

    The article describes the use of the tool of neuro-linguistic programming, such as anchoring, with examples of political and economic advertising. In various examples, the authors have demonstrated the overall impact on the psychology of the consumer. Examined the hypothesis that separating Economics and politics marketing specialists lose a lot. The authors propose to look at these two vectors through a single prism of the tools of marketing and psychology. Both in politics and in the econom...

  14. GPI-anchored influenza hemagglutinin induces hemifusion to both red blood cell and planar bilayer membranes

    OpenAIRE

    1995-01-01

    Under fusogenic conditions, fluorescent dye redistributed from the outer monolayer leaflet of red blood cells (RBCs) to cells expressing glycophosphatidylinositol-anchored influenza virus hemagglutinin (GPI- HA) without transfer of aqueous dye. This suggests that hemifusion, but not full fusion, occurred (Kemble, G. W., T. Danieli, and J. M. White. 1994. Cell. 76:383-391). We extended the evidence for hemifusion by labeling the inner monolayer leaflets of RBCs with FM4-64 and observing that t...

  15. Would an inflation target help anchor U.S. inflation expectations?

    OpenAIRE

    Eric T. Swanson

    2006-01-01

    Since the October 2005 nomination of Ben Bernanke to become Chairman of the Federal Reserve Board, there has been increasing speculation in the financial press that the Federal Open Market Committee (FOMC) might soon adopt an explicit numerical objective for inflation. However, skeptics of inflation targeting have maintained that this would constrain the FOMC and might provide little benefit in return—after all, it has been argued, haven't inflation expectations in the U.S. been well anchored...

  16. Reactor building comprising a vessel well anchored in a slab wedged at its periphery

    International Nuclear Information System (INIS)

    This reactor building includes a containment enclosure within which are positioned internal structures composed of a internal structures raft, a vessel well, a bearing slab being placed between the general raft and the internal structures raft, the vessel well being anchored in the bearing slab wedged on its periphery against the bottom part of the containment enclosure skirt, a horizontal slide seal being placed between the bearing slab and the internal structures raft

  17. Repair of acute injuries of the lateral ligament complex of the ankle by suture anchors

    OpenAIRE

    Liu, Xiang-Fei; Fang, Yang; Cao, Zhong-Hua; Li, Guang-Feng; Guo-qing YANG

    2015-01-01

    Objective: The objective of this study was to investigate the clinical curative effect of stage I repair of acute injuries of the lateral ligament complex of the ankle by the application of suture anchors. Methods: We retrospectively analyzed 18 cases of III degree acute injuries of the lateral ligament complex of the ankle. Results: There were statistically significant differences in preoperative and last follow-up VAS pain scores and AOFAS ankle hind-foot function scores. The X-ray talus di...

  18. Identification of a lipid-anchored heparan sulfate proteoglycan in Schwann cells

    OpenAIRE

    1990-01-01

    Schwann cells synthesize both hydrophobic and peripheral cell surface heparan sulfate proteoglycans (HSPGs). Previous analysis of the kinetics of radiolabeling suggested the peripheral HSPGs are derived from the membrane-anchored forms (Carey, D., and D. Evans. 1989. J. Cell Biol. 108:1891-1897). Peripheral cell surface HSPGs were purified from phytic acid extracts of cultured neonatal rat sciatic nerve Schwann cells by anion exchange, gel filtration, and laminin-affinity chromatography. Appr...

  19. Interaction of Rupture Zones of Adjacent Anchor Plates in an Analogical Medium

    OpenAIRE

    Abbad, H.; M. Meghachou; C. Dekar; S. M. Daoud

    2013-01-01

    In this paper, an experimental study which required the design and implementation of a model containing plastic granules powder to simulate a natural environment, is presented. The latter is subjected to the removal of "anchor plates." For each test, several digital photographs are taken to materialize different deformed configurations during the pullout process. These photos processed in couples by the 7D software (image correlation) giving the evolution of the displacement field and plane s...

  20. Activated radixin is essential for GABAA receptor α5 subunit anchoring at the actin cytoskeleton

    OpenAIRE

    Loebrich, Sven; Bähring, Robert; Katsuno, Tatsuya; Tsukita, Sachiko; Kneussel, Matthias

    2006-01-01

    Neurotransmitter receptor clustering is thought to represent a critical parameter for neuronal transmission. Little is known about the mechanisms that anchor and concentrate inhibitory neurotransmitter receptors in neurons. GABAA receptor (GABAAR) α5 subunits mainly locate at extrasynaptic sites and are thought to mediate tonic inhibition. Notably, similar as synaptic GABAARs, these receptor subtypes also appear in cluster formations at neuronal surface membranes and are of particular interes...

  1. Ligation-anchored PCR unveils immune repertoire of TCR-beta from whole blood

    OpenAIRE

    Gao, Fan; Kai WANG

    2015-01-01

    Background As one of the genetic mechanisms for adaptive immunity, V(D)J recombination generates an enormous repertoire of T-cell receptors (TCRs). With the development of high-throughput sequencing techniques, systematic exploration of V(D)J recombination becomes possible. Multiplex PCR has been previously developed to assay immune repertoire; however, the use of primer pools leads to inherent biases in target amplification. In our study, we developed a “single-primer" ligation-anchored PCR ...

  2. Peripunctal "anchor" suture for securing the silicone bicanalicular stent in the repair of canalicular lacerations.

    Science.gov (United States)

    Benger, Ross S; Nemet, Arie Y

    2008-01-01

    We used punctal absorbable suture in 8 patients (8 eyes) for silicone stent stabilization in canalicular repair surgery to prevent the postoperative complication of "cheese-wiring." Postoperatively there was 1 case of cheese-wiring of the repaired canaliculus, and no other complication related to the bicanalicular stent. The pericanalicular "anchor" suture may reduce the incidence of cheese-wiring by silicone bicanalicular stents after repair of canalicular lacerations or resections for stenosis. PMID:18209644

  3. Substrate-anchored and degradation-sensitive anti-inflammatory coatings for implant materials

    OpenAIRE

    Duo Wu; Xingyu Chen; Tianchan Chen; Chunmei Ding; Wei Wu; Jianshu Li

    2015-01-01

    Implant materials need to be highly biocompatible to avoid inflammation in clinical practice. Although biodegradable polymeric implants can eliminate the need for a second surgical intervention to remove the implant materials, they may produce acidic degradation products in vivo and cause non-bacterial inflammation. Here we show the strategy of “substrate-anchored and degradation-sensitive coatings” for biodegradable implants. Using poly(lactic acid)/hydroxyapatite as an implant material mode...

  4. Sialic Acid within the Glycosylphosphatidylinositol Anchor Targets the Cellular Prion Protein to Synapses.

    Science.gov (United States)

    Bate, Clive; Nolan, William; McHale-Owen, Harriet; Williams, Alun

    2016-08-12

    Although the cellular prion protein (PrP(C)) is concentrated at synapses, the factors that target PrP(C) to synapses are not understood. Here we demonstrate that exogenous PrP(C) was rapidly targeted to synapses in recipient neurons derived from Prnp knock-out((0/0)) mice. The targeting of PrP(C) to synapses was dependent upon both neuronal cholesterol concentrations and the lipid and glycan composition of its glycosylphosphatidylinositol (GPI) anchor. Thus, the removal of either an acyl chain or sialic acid from the GPI anchor reduced the targeting of PrP(C) to synapses. Isolated GPIs (derived from PrP(C)) were also targeted to synapses, as was IgG conjugated to these GPIs. The removal of sialic acid from GPIs prevented the targeting of either the isolated GPIs or the IgG-GPI conjugate to synapses. Competition studies showed that pretreatment with sialylated GPIs prevented the targeting of PrP(C) to synapses. These results are consistent with the hypothesis that the sialylated GPI anchor attached to PrP(C) acts as a synapse homing signal. PMID:27325697

  5. Anchoring of Expectations: The Role of Credible Targets in a Game Experiment

    Directory of Open Access Journals (Sweden)

    Bodo Herzog

    2015-10-01

    Full Text Available This paper provides new evidence on the formation and anchoring of inflation expectations. I conduct a game experiment and analyze the adjustment as well as the impact of credible targets on expectations. In addition, I evaluate the idiosyncratic determinants on the formation of expectations. The analysis reveals six results: First, I find evidence that long-term inflation expectations are firmly anchored to a credible target. Second, a temporary deviation due to unexpected monetary policy might trigger a decline in credibility, and third a de-anchoring of expectations due to uncertainty. Fourth, I find that people change their expectations little if a credible target exists. Fifth, expectations exhibit a large degree of time-variance only in environments without a target. Sixth, the dynamic adjustment to an ‘incomplete’ equilibrium, which is theoretically unstable, is nevertheless rapid and persistent in case of credible targets. All in all, I demonstrate a unique game setup with contributions to both experimental and monetary economics.

  6. Tension-compression asymmetry in the binding affinity of membrane-anchored receptors and ligands

    Science.gov (United States)

    Xu, Guang-Kui; Liu, Zishun; Feng, Xi-Qiao; Gao, Huajian

    2016-03-01

    Cell adhesion plays a crucial role in many biological processes of cells, e.g., immune responses, tissue morphogenesis, and stem cell differentiation. An essential problem in the molecular mechanism of cell adhesion is to characterize the binding affinity of membrane-anchored receptors and ligands under different physiological conditions. In this paper, a theoretical model is presented to study the binding affinity between a large number of anchored receptors and ligands under both tensile and compressive stresses, and corroborated by demonstrating excellent agreement with Monte Carlo simulations. It is shown that the binding affinity becomes lower as the magnitude of the applied stress increases, and drops to zero at a critical tensile or compressive stress. Interestingly, the critical compressive stress is found to be substantially smaller than the critical tensile stress for relatively long and flexible receptor-ligand complexes. This counterintuitive finding is explained by using the Euler instability theory of slender columns under compression. The tension-compression asymmetry in the binding affinity of anchored receptors and ligands depends subtly on the competition between the breaking and instability of their complexes. This study helps in understanding the role of mechanical forces in cell adhesion mediated by specific binding molecules.

  7. Electrical properties and mechanical stability of anchoring groups for single-molecule electronics

    Directory of Open Access Journals (Sweden)

    Riccardo Frisenda

    2015-07-01

    Full Text Available We report on an experimental investigation of transport through single molecules, trapped between two gold nano-electrodes fabricated with the mechanically controlled break junction (MCBJ technique. The four molecules studied share the same core structure, namely oligo(phenylene ethynylene (OPE3, while having different aurophilic anchoring groups: thiol (SAc, methyl sulfide (SMe, pyridyl (Py and amine (NH2. The focus of this paper is on the combined characterization of the electrical and mechanical properties determined by the anchoring groups. From conductance histograms we find that thiol anchored molecules provide the highest conductance; a single-level model fit to current–voltage characteristics suggests that SAc groups exhibit a higher electronic coupling to the electrodes, together with better level alignment than the other three groups. An analysis of the mechanical stability, recording the lifetime in a self-breaking method, shows that Py and SAc yield the most stable junctions while SMe form short-lived junctions. Density functional theory combined with non-equlibrium Green’s function calculations help in elucidating the experimental findings.

  8. Astral microtubule pivoting promotes their search for cortical anchor sites during mitosis in budding yeast.

    Directory of Open Access Journals (Sweden)

    Stephan Baumgärtner

    Full Text Available Positioning of the mitotic spindle is crucial for proper cell division. In the budding yeast Saccharomyces cerevisiae, two mechanisms contribute to spindle positioning. In the Kar9 pathway, astral microtubules emanating from the daughter-bound spindle pole body interact via the linker protein Kar9 with the myosin Myo2, which moves the microtubule along the actin cables towards the neck. In the dynein pathway, astral microtubules off-load dynein onto the cortical anchor protein Num1, which is followed by dynein pulling on the spindle. Yet, the mechanism by which microtubules target cortical anchor sites is unknown. Here we quantify the pivoting motion of astral microtubules around the spindle pole bodies, which occurs during spindle translocation towards the neck and through the neck. We show that this pivoting is largely driven by the Kar9 pathway. The microtubules emanating from the daughter-bound spindle pole body pivot faster than those at the mother-bound spindle pole body. The Kar9 pathway reduces the time needed for an astral microtubule inside the daughter cell to start pulling on the spindle. Thus, we propose a new role for microtubule pivoting: By pivoting around the spindle pole body, microtubules explore the space laterally, which helps them search for cortical anchor sites in the context of spindle positioning in budding yeast.

  9. An evaluation of tensile capacity of cast-in-place anchor with crack

    International Nuclear Information System (INIS)

    Actual model tests are carried out to develop the model that can accurately incorporate the effect of the various types of cracks in this study. These tests are intended for the cast-in-place anchor that is widely used for the fastening of equipment in Korean NPPs. 115 test specimens with single anchor are constructed on a basis of ASTM E488 under 23 cracked conditions and plain concrete for these actual model tests. As principal test variables related to crack, the crack width, the crack depth, and the distance between crack and anchor etc. are chosen. In order to apply the tensile force, 100 tonf-capacity actuator is used with displacement control of 0.5 mm/min. Through these test results, the model incorporating the effect of various types of cracks accurately, is developed and will be available for the an chorage capacity evaluation for seismic qualification of equipment in USI A -46 NPPs and anchorage design of new NPPs

  10. Role of suture anchors in management of fractures of inferior pole of patella

    Directory of Open Access Journals (Sweden)

    Anand Ashish

    2010-01-01

    Full Text Available Background: The traditional recommendation for displaced comminuted inferior pole fractures is excision of the comminuted pole followed by reattachment of the patellar tendon with transosseous suture. To the best of our knowledge there has been no previous published study mentioning the use of suture anchors for fracture inferior pole of patella. We present a retrospective analysis of five cases of patients doing well at final follow-up of two years. Materials and Methods: Five patients treated at our institute using suture anchors for repair of comminuted inferior pole fractures of patella between January 2007 to March 2007. (range 28 years-55 years. There were three males and two females. Results: The average follow-up was 25 months (range 24 months-26 months. The patients were evaluated for range of motion, strength, patellofemoral scores and any alteration of patellar height. The outcome of the procedure was assessed with use of the patellofemoral scoring system of Noyes et al, 5 as adapted by Saltzman et al. 6 The final patellofemoral score (maximum 100 points was 94.6 (range 93-96. Conclusion: We believe it is a novel extended indication of the use of suture anchors and should be in the armament of every trauma surgeon.

  11. High-resolution structure of TBP with TAF1 reveals anchoring patterns in transcriptional regulation

    Science.gov (United States)

    Anandapadamanaban, Madhanagopal; Andresen, Cecilia; Helander, Sara; Ohyama, Yoshifumi; Siponen, Marina I.; Lundström, Patrik; Kokubo, Tetsuro; Ikura, Mitsuhiko; Moche, Martin; Sunnerhagen, Maria

    2016-01-01

    The general transcription factor TFIID provides a regulatory platform for transcription initiation. Here we present the crystal structure (1.97 Å) and NMR analysis of yeast TAF1 N-terminal domains TAND1 and TAND2 when bound to yeast TBP, together with mutational data. The yTAF1-TAND1, which in itself acts as a transcriptional activator, binds into the DNA-binding TBP concave surface by presenting similar anchor residues to TBP as E. coli Mot1 but from a distinct structural scaffold. Furthermore, we show how yTAF1-TAND2 employs an aromatic and acidic anchoring pattern to bind a conserved yTBP surface groove traversing the basic helix region, and we find highly similar TBP-binding motifs also presented by the structurally distinct TFIIA, Mot1 and Brf1 proteins. Our identification of these anchoring patterns, which can be easily disrupted or enhanced, provides compelling insight into the competitive multiprotein TBP interplay critical to transcriptional regulation. PMID:23851461

  12. Gastrotomy closure with a new tissue anchoring device: A porcine survival study

    Institute of Scientific and Technical Information of China (English)

    Carlos Guarner-Argente; Henry Córdova; Graciela Martínez-Pallí; Ricard Navarro-Ripoll; Antonio Rodríguez-d'Jesús; Cristina Rodríguez de Miguel; Mireia Beltrán; Gloria Fernández-Esparrach

    2011-01-01

    AIM: To evaluate the feasibility, reproducibility and efficacy of a new tissue anchoring device in a porcine survival model.METHODS: Gastrotomies were performed using a needle-knife and balloon dilator in 10 female Yorkshire pigs weighing 30-35 kg. Gastric closure was attempted usinga new tissue anchoring device. The tightness of the closure was confirmed by means of air insufflation and the ability to maintain gastric distension with stability in peritoneal pressure measured with a Veress needle. All animals were monitored daily for signs of peritonitis and sepsis over 14 d. During necropsy, the peritoneal cavity and the gastric access site were examined.RESULTS: Transgastric access, closure and 14 d survival was achieved in all pigs. The mean closure timewas 18.1 ± 19.2 min and a mean of 2.1 ± 1 devices were used. Supplementary clips were necessary in 2 cases. The closure time was progressively reduced(24.8 ± 13.9 min in the first 5 pigs vs 11.4 ± 5.9 min in the last 5, P = NS). At necropsy, the gastric access site was correctly closed in all cases with all brace-bars present. One device was misplaced in the mesocolon.Minimal adhesions were observed in 3 pigs and signs of mild peritonitis and adhesions in one.CONCLUSIONS: The use of this new tissue anchoring device in porcine stomachs is feasible, reproducible and effective and requires a short learning curve.

  13. Numerical simulation of the effect of coupling support of bolt-mesh-anchor in deep tunnel

    Institute of Scientific and Technical Information of China (English)

    SUN Xiao-ming; CAI Feng; YANG Jun; CAO Wu-fu

    2009-01-01

    The mechanical effects of bolt-mesh-anchor coupling support in deep tunnels were studied by using a numerical method, based on deep tunnel coupling supporting techniques and non-linear deformation mechanical theory of rock mass at great depths. It is shown that the potential of a rigid bolt support can be efficiently activated through the coupling effect between a bolt-net support and the surrounding rock. It is found that the accumulated plastic energy in the surrounding rock can be sufficiently transformed by the coupling effect of a bolt-mesh-tray support. The strength of the surrounding rock mass can be mobilized to control the deformation of the surrounding rock by a pre-stress and time-space effect of the anchor support. The high stress transformation effect can be realized by the mechanical coupling effect of the bolt-mesh-anchor support, whereby the force of the support and deformation of the surrounding rock tends to become uniform, leading to a sustained stability of the tunnel.

  14. Secreted form of the human interleukin 2 receptor encoded by an anchor minus cDNA

    International Nuclear Information System (INIS)

    The DNA sequence encoding all of the putative intracytoplasmic domain and most of the trans-membrane domain of the huma IL 2 receptor was detected from a full length receptor cDNA. After expression in mouse L cells, the resultant anchor minus cDNA was found to direct the synthesis of a secreted rather than membrane-associated form of the IL 2 receptor. The secreted receptor protein (44,000 to 46,000 M/sub r/) retained the capacity to bind both IL 2 and the monoclonal anti-Tac antibody, as evidenced by (1) retention on IL 2 and anti-Tac affinity columns, (2) inhibition of [3H]-antiTac binding to HUT 102B2 cells, and (3) partial inhibition of IL 2-induced CTLL proliferation. Removal of these domains from the IL 2 receptor did not alter the post-translational processing or rate of export of the truncated receptor protein. These data confirm the proposed membrane orientation of the IL 2 receptor (NH2 terminus out, COOH terminus in) and underscore the anchoring function of this carboxy terminal receptor segment. The availability of such anchor minus receptor cDNA constructs may facilitate purification of large quantities of receptor protein for further analysis of receptor structure, valency, and localization of the IL 2 binding site(s)

  15. Evaluation of postoperative results from videoarthroscopic treatment for recurrent shoulder dislocation using metal anchors

    Directory of Open Access Journals (Sweden)

    Éder Menegassi Martel

    2016-02-01

    Full Text Available ABSTRACT OBJECTIVE: To clinically and radiologically evaluate the results from videoarthroscopic treatment using metal anchors in patients with recurrent shoulder dislocation and its complications. METHODS: This was a retrospective study on 47 patients (47 shoulders operated by the shoulder group of the orthopedic hospital between February 2010 and February 2012. A questionnaire, interview and physical and radiographic examinations were used, with the classification of Samilson and Pietro. The mean postoperative follow-up was 33 months (range 12-47 months. The statistical analysis consisted of using Fisher's exact test through the IBM SPSS 22 statistical software. The significance level used was 5%. RESULTS: Recurrence was observed in nine cases. The patients were, on average, 26.5 years old at the first episode, and 19.1% were aged 20 years or under. Among these, 55.6% presented recurrence. In relation to age at the time of the surgical procedure, the average age was 27 years, and 12.8% were aged 20 years or under. Nineteen patients presented prominent anchors and, of these, 21% manifested arthrosis. CONCLUSION: There was a statistically identified correlation between the recurrence rate and age less than or equal to 20 years at the times of first dislocation and the surgical procedure. Further studies should be conducted in order to compare the use of absorbable anchors, which despite higher cost, may provide lower risk of developing glenohumeral arthrosis in some cases.

  16. Device Design and Test of Fatigue Behaviour of Expansion Anchor Subjected to Tensile Loads

    Directory of Open Access Journals (Sweden)

    Zhang Jinfeng

    2016-01-01

    Full Text Available In order to study on the fatigue behaviour of expansion anchor (M16, grade 8.8 for overhead contact system in electrification railways, a set of safe, practical loading device is designed and a fatigue test campaign was carried out at structural laboratory of China Academy of Building Research on expansion anchor embedded in concrete block. The mobile frame of the loading device was designed well by finite-element simulation. According to some fatigue performance test of expansion anchor with different size and form, the device have been assessed experimentally its dependability. The results were found that no fatigue damage phenomenon occurred in all specimens after 2×106 cycles tensile fatigue test in this specific series. It shows that in the condition of medium level or slightly lower maximum stress limit and nominal stress range, expansion bolt has good fatigue resistance. The biggest relative displacement and the residual relative displacement after test (Δδ = δ2-δ1 was also strongly lower than the symbol of the fatigue test failure index of this specific series (0.5mm in the high cycle fatigue regime. The ultimate tension failures mode after fatigue tests in all tested samples take place in the concrete anchorage zone. The reduction range of the ultimate tensile strength properties of the anchorage system was not obvious, and the concrete was seen to be the weakest link of the system.

  17. Anchor-wire technique for multiple plastic biliary stents to prevent stent dislocation

    Institute of Scientific and Technical Information of China (English)

    Tsuyoshi Hamada; Kazuhiko Koike; Yousuke Nakai; Saburo Matsubara; Hiroyuki Isayama; Akiko Narita; Kazuhiro Watanabe; Yukihiro Koike; Shigeo Matsukawa; Tateo Kawase

    2011-01-01

    In endoscopic placement of multiple plastic biliary stents (PBSs), we sometimes experience proximal dislocation of the first PBS at the time of subsequent PBS insertion. We describe the case of a 79-year-old male with obstructive jaundice caused by cholangiocarcinoma who needed to receive multiple PBS placements for management of cholangitis. Although proximal dislocation of the first PBS was observed, we prevented the dislocation via our technique of using guidewire inserted from the distal end of the first PBS to the side hole as the anchor-wire. We could complete this technique only by inserting guidewire through the side hole of the first PBS during the process of releasing the first PBS and pulling out the guidewire and the inner sheath. It did not matter whether the anchor-wire went towards the third portion of the duodenum or the duodenal bulb. Here we introduce this "anchor-wire technique", which is useful for the prevention of PBS proximal dislocation in placing multiple PBSs.

  18. Stresses induced by post-tensioned anchor in jointed rock mass

    Institute of Scientific and Technical Information of China (English)

    Alan Showkati; Parviz Maarefvand; Hossein Hassani

    2015-01-01

    A new analytical study on stresses around a post-tensioned anchor in rocks with two perpendicular joint sets is presented. The assumptions of orthotropic elastic rock with plane strain conditions are made in derivation of the formulations. A tri-linear bond-slip constitutive law is used for modeling the tendon-grout interface behavior and debonding of this interface. The bearing plate width is also considered in the analysis. The obtained solutions are in the integral forms and numerical techniques that have been used for evaluation. In the illustrative example given, the major principal stress is compressive in the anchor free zone and compressive stress concentrations of 815 kPa and 727 kPa (for the anchor load of 300 kN) are observed under the bearing plate and the bond length proximal end, respectively. However, large values of tensile stresses with the maximum of−434 kPa are formed at the bond length distal end. The results obtained using the proposed solution are compared very those of numerical method (FEM).

  19. Operative treatment of acromioclavicular joint dislocation:a new technique with suture anchors

    Institute of Scientific and Technical Information of China (English)

    Zhang Jingwei; Li Min; He Xianfeng; Yu Yihui; Zhu Limei

    2014-01-01

    Objective:To evaluate clinical outcome of suture anchors in strengthening both acromioclavicular and coracoclavicular ligaments in the surgical treatment of acromioclavicular joint dislocation.Methods:Twenty-eight patients with acute traumatic Rockwood Ⅲ,Ⅳ and Ⅴ dislocations of the acromioclavicular joint surgically treated at our institute between October 2010 and January 2012 were recruited.All patients underwent open reduction combined with suture anchors.Function was evaluated using the ConstantMurley shoulder score.Clinical and radiographic shoulder ratings were evaluated using Taft criteria at 3,6 and 12 months.Results:Two cases with fixation loosening were not included in final statistical analysis.Other patients obtained full joint reposition on immediate postoperative radiographs.Follow-up was performed with an average of 15.6 months (range,12-19).After early range of motion exercises,96.2% of the patients (25/26) could abduct and elevate their shoulders more than 90 degrees within postoperative 3 months.There was no infection.Average Constant-Murley score was 96.3 points (range,94-100)and mean Taft shoulder rating was 10.7 points (range,8-12) at 12 months.Conclusion:The suture anchor is a relatively simple technique and can avoid screw removal which is helpful in reconstructing both acromioclavicular and coracoclavicular ligaments in acute traumatic acromioclavicular joint dislocation.

  20. Geometric Nonlinear Analysis of Self-Anchored Cable-Stayed Suspension Bridges

    Directory of Open Access Journals (Sweden)

    Wang Hui-Li

    2013-01-01

    Full Text Available Geometric nonlinearity of self-anchored cable-stayed suspension bridges is studied in this paper. The repercussion of shrinkage and creep of concrete, rise-to-span ratio, and girder camber on the system is discussed. A self-anchored cable-stayed suspension bridge with a main span of 800 m is analyzed with linear theory, second-order theory, and nonlinear theory, respectively. In the condition of various rise-to-span ratios and girder cambers, the moments and displacements of both the girder and the pylon under live load are acquired. Based on the results it is derived that the second-order theory can be adopted to analyze a self-anchored cable-stayed suspension bridge with a main span of 800 m, and the error is less than 6%. The shrinkage and creep of concrete impose a conspicuous impact on the structure. And it outmatches suspension bridges for system stiffness. As the rise-to-span ratio increases, the axial forces of the main cable and the girder decline. The system stiffness rises with the girder camber being employed.