A. S. Kolbin
Full Text Available Background: Omalizumab is the first and yet the only biopreparation for asthma which combines high efficiency and high cost. The clinical-economic expediency of using omalizumab in asthmatic children has not been previously studied in Russia.Objective: Our aim was to evaluate the clinical and economic expediency of using omalizumab as additive treatment (to basic or supporting therapy in children with severe uncontrolled atopic asthma under the Russian economic conditions.Methods: We conducted a mathematical simulation of asthma treatment in children with an increased frequency of hospitalization (9 times per year with an average monthly omalizumab requirement of 558 mg. The model is based on the Markov chain. The model includes direct and non-direct costs. The planning horizons were 2 and 5 years. We analyzed the efficiency and utility of the costs and their influence on the budget. The stability of received data is proven by sensitivity analyzis.Results: Over a 5-year planning horizon the cost of an additional year of quality life (due to using omalizumab was 1,259,185 roubles, while the “society’s solvency” is 1 341 308 roubles (cost utility analizis. It takes 39,820 rubles to prevent one hospitalization with omalizumab over a 5-year planning horizon (cost efficiency analizis, which is comparable to the cost of hospitalization (43,141 rubles. Total costs for treating 100 children with asthma, 7 of which would be treated with omalizumab, were equal to the amount of money which is enough to treat 105 children without omalizumab (analysis of budgetary influence.Conclusion: The analyses of cost efficiency and utility have shown that the strategy of using omalizumab together with standard treatment is economically expedient. Budgetary influence analysis has not detected a significant burden on the budget.
Title: Study of H3 + recombination in selected quantum states Author: Jozef Varju Department : Department of Surface and Plasma Science Supervisor of the doctoral thesis: Prof. RNDr. Juraj Glosík, DrSc., Department of Surface and Plasma Science Abstract: In this work measurement of the effective recombination rate coefficient of H3 + dominated and recombination governed afterglow plasma at 77 K and 145 K are presented. Population of para-H3 + in the studied plasma has been varied by using par...
Soós, V.; Sebestyén, E.; Juhász, A.; Light, M. E.; Kohout, Ladislav; Szalai, G.; Tandori, J.; van Staden, J.; Balázs, E.
Roč. 10, č. 236 (2010), s. 1-15 ISSN 1471-2229 Institutional research plan: CEZ:AV0Z40550506 Keywords : smoke compound * transcriptome * KAR1 * butenolide Subject RIV: CC - Organic Chemistry Impact factor: 4.085, year: 2010
This paper presents a simple embodiment of the system that can be used for the primary stability analysis of the cemented hip prosthesis. The proposed variant is based on experimental test stand for hip prostheses (in terms of tribology) found in Biomechatronics Lab of the Product Design and Environment Faculty. For this study three aspects are important: counting the number of cycles that it performs cemented hip prosthesis and the time when the first microdisplacements ...
Carlos Alberto Mussel Barrozo
Full Text Available O estudo objetivou avaliar resultados imediatos e tardios da cirurgia das reoperações em pacientes portadores de valvopatias, analisando o seguimento do paciente e não da prótese empregada. Foram analisados retrospectivamente 697 (419 fem. e 278 masc. pacientes que foram reoperados entre 1970 a 1993. A idade média foi de 43,4±17,9 anos. Como diagnóstico pré-operatório, 281 (40,3% apresentavam disfunção de prótese, 212 (30,5% reestenose pós comissurotomia, 103 (14,7% tiveram rotura e 101 (14,5% trombose da prótese. Reoperação em valvopatias representou uma média de 7,38% de todo o movimento cirúrgico do Serviço, sendo, nos últimos 2 anos, 26,7% das operações por valvopatia. A mortalidade hospitalar foi de 9,89%, e o intervalo entre a 1º e a 2º operação foi de 77±37 meses. Desses pacientes, 110 já foram submetidos a uma 3º operação no nosso Serviço, com intervalo médio de 81±28 meses e 10 já foram submetidos a uma 4º operação. A mortalidade tardiafoi de 16,6% e o seguimento médio de 14 anos, com perda de seguimento de 18,7% de pacientes. Ao contrário da maioria dos estudos de reoperações onde é acompanhada a evolução de determinada prótese, nós procuramos enfocar o paciente e sua evolução clínica. Os resultados demonstram que a incidência de reoperações na prática do Serviço vem aumentando sucessivamente e que esse tipo de operação pode ser realizado com um risco aceitável, e seus resultados, ainda que não excelentes a longo prazo, permitem ao paciente uma sobrevida razoável e a oportunidade de uma nova operação.The aim of this study was to analyze the early and late results of the reoperation for valvar disease with the focus on the patient not on the prosthesis. A retrospective analysis of 697 patients (419 female, 278 male was done between 1970 and 1990. The mean age was 43.4+17.9 years old. Pre-operative diagnosis were 281 (40.3% prosthesis dysfunction, (2/2 30.5% restenosis pos-comissurotomy, (103 4,7% prosthesis rupture, 101 (14.5% prosthesis thrombosis. Reoperations for valvopathy were 7.38% of the total surgical procedures in our Service, and in the last 2 years 26.7% of the total valvar surgery procedures. The hospital mortality was 9.89%, and the mean interval between the first and second procedure was 77+37 months. A third operation was carry on 110 patients with the mean interval of 81+28 and 10 had a fourth intervention. The late mortality was 16.6% and the mean follow up is 14 years with 18.7% lost of segment. Different from others studies where the prosthesis have been followed, our main goal was followthe patient's clinical evolution. The results shown that reoperations for valvopathy have increased in our Institution. The procedure can be done with an acceptable risk even though the long term results are not excellent the patients can have a reasonable survival and a chance of a new operation.
Full Text Available Predložena praca bola zamerana na stanovenie obsahu vybranych fenolovych zlučenin (celkove fenoly, triesloviny, flavonoidy a antokyany troch roznych druhov rodu Thymus (T. pulegioides, T. pannonicus, T. praecox s rozdielnym povodom (Českomoravska vrchovina, Křivoklat a Považsky Inovec. Na stanovenie tychto zložiek boli využite spektrofotometricke metody Europskeho liekopisu, 8. vydanie. Zaroveň bol stanoveny aj obsah silice a bola vykonana analyza jej zložiek. Obsah celkovych polyfenolov bol stanoveny spektrofotometrickou metodou s využitim Folin-Ciocalteovho činidla. Obsah kolisal od 3.87 % do 8,86 %. Obsah trieslovin bol realizovany na zaklade predošleho stanovenia obsahu celkovych fenolov, a to adsorpciou trieslovin na kožny prašok. Ich obsah sa pohyboval v rozmedzi 1,96 % do 5,65 %. Na stanovenie obsahu flavonoidov bola využita spektrofotometricka metoda s chloridom hlinitym. Obsah flavonoidov vyjadrenych ako luteolin-7-O-glukozid (λ = 392 nm kolisal od 0,59 % do 1,52 % a obsah flavonoidov vyjadrenych ako rutin (λ = 420 nm sa pohyboval v rozmedzi od 0,41 % do 1,12 %. Antokyany zaberaju v ramci fenolovych zložiek rodu Thymus len minimalny podiel. V našich vzorkach bol obsah antokyanov vyjadreny ako cyanidin-3- O-glukozid a kolisal od 0,02 % do 0,1 %. Na stanovenie obsahu silice bola využita metoda Europskeho liekopisu, 8.vydanie. Obsah silice sa pohyboval v rozmedzi od 0,2 % do 0,75 %. Na analyzu silice bola nasledne využita metoda plynovej chromatografie s hmotnostnou spektrometriou. Na zaklade tejto analyzy bola zistena pritomnosť troch chemotypov silice, a to tymoloveho, karvakroloveho a linalooloveho chemotypu. Vďaka variaciami chemickeho zloženia silice, bolo možne pozorovať vzťah medzi pritomnosťou určiteho chemotypu a povodom vzorky. Rozdiely v stanoveni obsahu flavonoidov nepreukazali žiadny vyrazny vzťah k lokalite povodu.
This report documents the work performed during phase two of Project 0-5534, Asset Management Texas : Style. This phase included gathering historical Texas Department of Transportation (TxDOT) right-of-way : acquisition information, analyzi...
Roč. 2016, č. 04 (2016), s. 23-26 ISSN 2336-5056 Institutional support: RVO:68081766 Subject RIV: EG - Zoology http://www.casopis. forum ochranyprirody.cz/magazin/analyzy-komentare/masozravci-na-prahu-mesta-pozoruhodna-flexibilita-selem-v-urbannim-prostredi
The character of activities of human resource management is in today's world wider and wider, to be a good employer is not enough, it is needed to communicate this message through various channels and grip potential employees, current employees and also the public. On the basis of analyzis of available sources, the thesis summarizes and completes current knowledge in the area of personnel marketing and employer branding, and proves the importance of personnel marketing in the discipline of hu...
The research aimed to measure the accuracy and combination of Classic and Modern Technical Analysis. PT Wijaya Karya Tbk (WIKA)’s stock in two periods is the sample of research. Technical analysis was used to predict stock prices by observing changes in historical share price. Practically, technical analysis is divided into Classic Technical and Modern. Research was conducted by library study and using a computer software. Microsft Excel was used for the simulation and Chart Nexus for analyzi...
Klinge Jacobsen, Henrik
Technological progress is an important issue in long-term energy demand projections and in environmental analyses. Different assumptions on technological progress and diffusion of new technologies are among the reasons for diverging results obtained using bottom-up and top-down models for analyzi...... of residential heat demand, fuel price increases are found to accelerate diffusion by increasing replacement rates for heating equipment....
The aim of my article is to describe the word “dream” and its meanings in the Leśmian’s poetry. The phrase itself is one of the most significant words which adds to Leśmian's works. In the first part I have done analyzis of grammatical categories of the word “dream” and I have distinguished three of them - verbal, adjectival and noun. Besides, I have analized the phrase-in question's word-formation. The conclusion I have drawn is that the nouns have been transformed with low fr...
Bouffioux, C.; Habraken, A.M.; Carton, M.; Lecomte-Beckers, J.
The prediction of the final axial stresses and the residual strains of complex extruded aluminium profiles requires a good knowledge of the material behavior and of the industrial process. This paper is focused on the methods required to provide the whole set of data: material ones and process ones. Scanning differential calorimetry, dilatometry and diffusivity tests identify thermophysic material properties and hot tensile tests identify parameters of the elasto-visco-plastic Norton-Hoff law. The description of the industrial process and its simulations are described. Then a sensitivity analyzis provides the cooling key parameters causing the undesired final curvature during the industrial process
Full Text Available Identifikacia druhov v rode Mentha L. je obzvlašť naročna. Je to sposobene ľahkym križenim podporenym gynodioeciou, ktora je ďalej skomplikovana polymorfizmom, pestovanim, polyploiditou a vegetativnym rozmnožovanim, čo vysvetľuje genetickopopulačne a mikroevolučne pozadie premenlivosti v rode Mentha. V tejto praci sme študovali využitie mikromorfologickych a fytochemickych parametrov pri identifikacii a charakterizacii vybranych druhov rodu Mentha. Na spodnej pokožke listov 20 populacii Mentha sme stanovili veľkosť a počet „žliazok typu Lamiaceae“. Silicu sme analyzovali pomocou GC MS. Identifikovali a charakterizovali sme populacie druhov M. × piperita, M. spicata, M. spicata subsp. condensata, M. spicata var. crispa, M. spicata var. citrata, M. × gentilis, M. aquatic, M. arvensis a M. longifolia. Sledovanie veľkosti a počtu „žliazok typu Lamiaceae prispievaju k charakterizacii niektorych druhov Mentha (najma M. longifolia a M. × piperita.
Stefanovic, Andrea B; Jovanovic, Jelena R; Balanc, Bojana D; Šekuljica, Nataša Ž; Tanaskovic, Sonja M Jakovetic; Dojcinovic, Marina B; Kneževic-Jugovic, Zorica D
The objective of this study was to discover the relationship between the ultrasound probe treatment (UPT) on egg white proteins (EWPs) before EWPs hydrolysis by different proteases, and the functional properties of the obtained hydrolysates. To fulfill this goal, the protein solubility, foaming, and emulsifying properties were studied as a function of the UPT time and then related to the surface characteristics and structural properties. The changes in the hydrolysates microstructures and macromolecular conformation, induced by the UPT, were followed using scanning electron microscope analyzis (SEM) and Fourier transforms infrared spectroscopy (FTIR). The results showed that UPT influenced (P < 0.05) the proteolysis of egg white proteins for all examined treatment times. Alcalase hydrolysates (AHs) and papain hydrolysates (PHs) were found to have a higher solubility, as a consequence of their relatively higher foaming, and emulsifying properties compared to the untreated hydrolysates. The changes in surface hydrophobicity, sulfhydryl content and surface charge of AHs and PHs indicated unfolding of EWPs affected by ultrasound. SEM analyzis showed that UPT destroyed the microstructures of AHs and PHs, while FTIR spectra indicated remarkable changes in the macromolecular conformation of AHs and PHs after UPT. This study revealed that by combining ultrasound pre-hydrolysis treatment under controlled conditions with thoughtful proteases selection, hydrolysates with improved functional properties could be produced, enhancing utilization of EWPs in food products.
V. V. Poliuha
Full Text Available The article interprets the gender issues and their interconnection of musical art that leads to analyzis of music pedagogy and educational system in general. The purpose of the study is the selection and analysis of such gender definitions of music as ender dimension, gender roles, gender approach, the gender component in the system of music education. Methodology of the study is based on the interdisciplinary approach that involves the use of scientific methods of analysis, synthesis and synthesis. Also, there is the method of comparative analysis and analogy applied in understanding the problems related to the study of gender influence in art and education. Originality is reflected in modern educational concept that appeals to the understanding of gender issues as a way of more thorough understanding of individuals, their role status of the individual, which in turn defines social opportunities in educational activities. Accordingly, the modern science can not remain uninvolved into the problems of modern times. Conclusions. Studies of gender in musical art education leads to selection, analyzis and understanding of such definitions as: gender dimension, which is focused on the understanding of the principle of obtaining polysynthetic, gender sensation from a musical work; gender roles, which distinguish representation of women in different kinds of music; gender approach, which establishes the availability of gender imbalance in the system of music education; gender component, which distinguishes the importance of understanding and practical implementation of gender equality in the system of music education.
Full Text Available This paper as a synthetic analyzis based on the Markowitz and Sharpe models deals with the problem of portfolio trying to determine both the optimum proportion of titles and the influence of a considered macroeconomic factor over their level of efficiency and risk. The improvement of these models was made through the introduction of a new model, the APT model (Arbitrage Price Theory, as a development of the uni-factorial CAPM model, in other words, the above-mentioned model only constitutes a particular form of the APT model trying to establish a relationship between the individual efficiency of a title from the portfolio and several macroeconomic factors. Also, this model involves the identification of macroeconomic factors influencing the profitability of the titles and the determination of the influence of these factors individually, through the application of the APT model.
Myriam Guadalupe Colmenares López
Full Text Available This research analyzes the labor´s sex segregation and its association with the wage differ-ence in the model of industrial development of import substitution as well as in theexportation industrial model, comparing the Guadalajara and El Salto metropolitan zoneand the city of Tijuana betwen 1989 and 1999.The segregation analyzis is based on a study of the concentration indexes and asynthetic segregation index. Their interrelationship with wages levels of every industrialbranch allows the study of the association between segregation by sex and salary differ-ences. The conclusion of this research is that the Guadalajara and El Salto metropolitanzone presents a stronger sexual segregation in the industry than in Tijuana, despite bothcities converge toward the same model of industrialization and exportation.
Pande Made Udiyani
Full Text Available Pengganti Bahan bakar UO2, yang tergolong uranium pengkayaan rendah, adalah bahan bakar MOX yang mempunyai pengkayaan yang lebih tinggi. Bahan bakar MOX mempunyai kandungan plutonium dan nuklida dari golongan aktinida yang lebih tinggi dibandingkan bahan bakar UO2, yang akan menghasilkan karakteristik radionuklida yang berbeda untuk setiap sub-sistem reaktor daya. Analisis radionuklida untuk setiap sub-sistem keselamatan pada reaktor daya berbahan bakar MOX dilakukan untuk mengetahui karakteristik radionuklida khususnya plutonium dan aktinida yang akan menimbulkan dampak radiasi dari lepasan radionuklida tersebut. Analisis dilakukan dengan cara menghitung dan mengamati radionuklida untuk setiap sub-sistem keselamatan pada operasi normal dan kecelakaan (small LOCA, large LOCA, severe accident untuk reaktor PWR berkapasitas 1000 MWe. Disimpulkan bahwa penggunaan bahan bakar MOX dapat menambah konsekuensi radiologis ke lingkungan dan masyarakat, terutama karena inventori yang lebih besar termasuk dari radionuklida transuranic dan dari golongan aktinida, antara lain: Pu-239, Am-241, Cm-242, Pu-240, Pu-241 dan Pu-242. Kata kunci: karakteristik nuklida, reaktor daya, bahan bakar, MOX Substitute UO2 fuel that low enrichment of uranium is that MOX fuel has a higher enrichment. MOX fuel has a content of plutonium and actinide nuclides a higher than UO2 fuel, which will produce different characteristics of radionuclides for each sub-system of power reactors. Analyzis of radionuclide for each safety sub-system at MOX power reactor aims to determine the characteristics of radionuclides, especially plutonium and actinides consequences. Analyzis has done by calculating and observing the radionuclide for each safety sub-system in normal operation and accident (small LOCA, large LOCA, and severe accident on PWR-1000 reactors. It can concluded that the use of MOX fuel can add to the radiological consequences to the environment and public, mainly because a
Full Text Available Purpose: The main purpose of this study was to compare the phenomenon of interfrm cooperation strategy in both hyper-growth, and stable-growth knowledge and technology–intensive frms, in a country characterized by a high level of generalized trust: Sweden. Methodology: Qualitative methods were incorporated: direct semistructured interviews with top managers in 13 ICT frms (8 hyper-growth and 5 stable-growth, analyzis of reports, corporate websites and press releases. Furthermore, interviews in 3 expert frms in the industry were conducted, facilitating interfrm cooperation. Conclusions: There were signifcant differences in interfrm cooperation strategy in two distinguished groups of the frms: hyper-growth, and stable-growth. Managers’ individual approaches to uncertainty, strategy and cooperation might be more important than institutional settings. The ICT frms operate in a constantly changing global environment and local context seems to have only a minor impact on the rules of the game in the industry. Research limitations: This study was a qualitative explorative approach as an introduction to further empirical research. Originality: The study presents an interfrm cooperation phenomenon incorporating different perspectives and settings. It contributes to alliance portfolio literature (forming and managing of alliance portfolio in a different context/country/industry, and enhances understanding of frm strategies characterized by different growth rates.
Zhao Wei; Yi Genfa; Hu Jihong; Xiang Shutian; Jiang Yongneng; Li Liyuan; Hu Zhengqin; Yang Huiying; Li Hong; Shen Lijuan; Zhang Huaxian
Objective: To study the expressions of Fas, FasL, Bax,Bcl-2 and P53 in thyroid tissue and to analyzis (Semi-quantitative analysis)the relation between change of apoptosis in thyroid tissues and clinical therapeutic effect after thyroid arterial embolization in treating hyperthyroidism caused by Graves' disease with observation of apoptosis for 3 years. Methods: 15 patients undergone core needle biopsy of the thyroid gland were divided into three groups according to the amount of time elapsed after thyroid arterial embolization: A group, before thyroid arterial embolization, B group, 1 year group (including 7-day subgroup, 3-month subgroup, 6-month subgroup) and C group, 1 year subgroup and mom than 1 year subgroup after arterial embolization. Results: (1) After embolisation, 15 patients' symptoms and signs of hyperthyroidism disappeared or improved greatly with 9 long term released and 6 improved with small amount of ATD maintenance. (2) The positive staining of Fas and FasL located in endochylema and cell-membrane of thyroid tissue from patients treated with transcathter arterial embolization were higher than those not treated with transcathter arterial embolization (P 0.05). (4) The positive cell and the staining of P53 in thyroid tissue had significant difference before and after thyroid arterial embolization (P<0.05). Conclusions: The extra-expression and the increased expression of Fas, FasL, Bax, P53 in thyroid tissue of patient with GD treated by thyroid arterial embolization are correlated with the effects of interventional therapy. (authors)
Full Text Available Prispevok sa zaobera otazkou, ktoru často riešia majitelia spoločenskych zvierat vo všetkych členskych štatoch EU. Poskytuje bližši pohľad na povinnosti spojene s cestovanim so zvieraťom medzi členskymi štatmi, alebo medzi členskym štatom a treťou - nečlenskou krajinou. Zameriava sa na nekomerčnu prepravu, ako je napriklad dovolenka, vylet a podobne. Praca prostrednictvom syntezy, analyzy a porovnania ponuka prehľad zakladnych legislativnych aktov v predmetnej oblasti. Venuje sa tiež otazke tzv. pet pasu, najdoležitejšieho identifikačneho dokladu, vyžadovaneho pre spoločenske zvierata na uzemi EU. Možno v nej najsť aj definicie najčastejšie použivanej terminologie.
Sales, Neuza Josina; Castaneda, Daniel Francisco Neyra; Barreto, Íkaro Daniel de Carvalho; Paoliello, Marina; Campanha, Silvia Márcia Andrade
To describe how public prosecutors self-assess their communication approaches and how listeners react to them; to analyze how this relates to gender, age, and work experience. Descriptive, transversal study. A questionnaire was developed and sent to 126 public prosecutors for completion. Thirty-three completed questionnaires were sent back. The independent variables were gender, age, and number of years of professional experience. The dependent variables were communication self-assessment throughout the years of work, communication parameters used, and listeners' reactions. A descriptive analyzis and Fisher's Exact Test was carried out. the sample contained both male and female participants with a median age of 43 years and an average of 20 years of professional experience. Most of the respondents claimed they had experienced demotivation, insecurity, tension, and difficulty when trying to convince listeners. More women than men reported they felt that their communication had worsened throughout their careers. All the women reported they experienced insecurity when speaking in public. One third of the public prosecutors stated they suffered from disorders on their voice. Those respondents aged over 43, experienced greater proportion on voice change than younger ones. In contrast to their younger colleagues, the majority of public prosecutors with more than 20 years of professional experience revealed that they felt insecure when speaking in public. the public prosecutors identified their strong and weak communication parameters. Gender, age, and work experience affect communicative performance.
The report is an investigation concerning strandby and actions by SKI (Swedish Nuclear Power Inspectorate) and SSI (National Institute of Radiation Protection) due to the Chernobyl reactor accident. It consists of a final report and two appendices. The final report is divided into two parts: 'I: Facts' and 'II: Analyzes'. 'Facts': The Swedish model for information: radio, press. Basic knowledge about ionizing radiation in the society. Resources for information. Need for information. Message forms for information. Announcements from the authorities in TV, radio, press, meeting, advertisements. Statements concerning the reactor accident and its consequences in Swedish mass media. How did the public recieve the information? 'Analyzis': Information responsibilities and policies. SSI information activities concerning radiologic accidents, conditions, methods and resources. Ditto for SKI, Swedish National Food Administration and the National Board of Agriculture. Appendix I: Information from authorities in the press three weeks after the Chernobyl accident: The material and the methods. The acute phase, the adoptation phase, the extension of the persective. What is said about the authorities in connection with Chernobyl? Appendix II: The fallout from Chernobyl, the authorities and the media coverage: The nationwide, regional and local coverage from radio and television. Ditto from the press. Topic and problem areas in reporting. Instructions from the authorities in media. Contribution in the media from people representing the authorities. Fallout in a chronologic perspective. (L.F.)
Znaien, J.; Moisy, F.; Hulin, J. P.; Salin, D.; Hinch, E. J.
2D PIV and LIF measurements have been performed on buoyancy driven flows of two miscible fluids of the same viscosity in a tube tilted at different angles θ from vertical and at different density contrasts (characterized by the Atwood number At). As θ increases and At decreases, the flow regime evolves, behind the front, from a turbulent shear flow towards a laminar counter flow with 3 layers of different concentrations. Time variations of the structure function show that both intermittent and developed turbulence occur in intermediate conditions. In the turbulent regime (Reλ˜60) the magnitudes of the longitudinal u'^2 and transverse v'^2 velocity fluctuations and of the component u'v' of the Reynolds stress tensor are shown to be largest on the tube axis while viscous stresses is only important close to the walls. The analyzis of the momentum transfer in the flow with buoyancy forces estimated from the concentration gradients demonstrates that 3D effects are required to achieve the momentum balance. These results are discussed in the framework of classical turbulence models.
Diana Puspita Sari
Full Text Available This research discusses mathematical models of joint economic lot size optimization in a supplier-buyer inventory system in a situation when the supplier offers decremental temporary discounts during a sale period. Here, the sale period consists of n phases and the phases of discounts offered descend as much as the number of phases. The highest discount will be given when orders are placed in the first phase while the lowest one will be given when they are placed in the last phase. In this situation, the supplier attempts to attract the buyer to place orders as early as possible during the sale period. The buyers will respon these offers by ordering a special quantity in one of the phase. In this paper, we propose such a forward buying model with discount-proportionally-distributed time phases. To examine the behaviour of the proposed model, we conducted numerical experiments. We assumed that there are three phases of discounts during the sale period. We then compared the total joint costs of special order placed in each phase for two scenarios. The first scenario is the case of independent situation – there is no coordination between the buyer and the supplie-, while the second scenario is the opposite one, the coordinated model. Our results showed the coordinated model outperform the independent model in terms of producing total joint costs. We finally conducted a sensitivity analyzis to examine the other behaviour of the proposed model. Keywords: supplier-buyer inventory system, forward buying model, decremental temporary discounts, joint economic lot sizing, optimization.
Lomba, M.; Conha, P.G. da; Almeida, C.E. de
The medical X-ray exposures due to radiological examinations are responsible for the largest contribution to the population collective dose as result of the normal use of artificial sources of radiation. The relative impact of the medical exposures to the total dose received by the population from all kinds of radiation sources varies from country to country and in some cases within the same country. The dose variations observed for a specific type of examination are in general associated to several factors i.e. the type of film-ecran combination, the choice of the appropriate physical parameters of the X-ray generator (Kvp, filament current, exposure time) and finally to the film processing conditions. At the present moment the data available in Brazil are scarce and scanty to allow a complete analyzis of this question so needed by the health authorities to justify the implementation of a quality assurance and dose reduction programs. In addition, it is desirable to establish a cost effective operation based on simple administrative concepts in order to reduce the number of films retake, then increasing the life expectancy of the equipment and the number of radiological procedures. The aim of this work was to assess the typical doses of an PA and LAT chest wall X-ray examinations in five different public hospitals (a University Hospital, a Cancer Hospital, a Navy Hospital, an Emergency Hospital and a State General Hospital), as representative of the city of Rio de Janeiro, and compare the results with the international data and recommendations available. (author)
Full Text Available Persons with Broca’s aphasia socialize in societymuch faster, because of the early rehabilitationtreatment using the speech therapy. In thebeginning of the illness, the voice production isarduous and the speech is with variable prosody.The patient expresses himself exceptionally withnouns and working verbs, also using mimics andgestures.The main purpose of the research is the evaluationof the communicational language skills of personswith Broca’s aphasia, even in the acuteness of theillness. The goal is also to examine and establishthe opinion of persons with Broca’s aphasia, theirfamily members and medical staff regarding theuse of early rehabilitation treatment with speechtherapy.The basic tasks of this research are to determinewhether the disturbance of verbal interaction isoften followed with speech apraxia andagrammatism among the persons suffering fromBroca’s aphasia. Two types of examinees areincluded in the research. The survey was conductedin Skopje and in a period of three months.The data gained from the research are grouped,tabulated, processed and graphically shownusing the program Microsoft Office Excel 2003.The differecnces in the data of the examinees isanalyzed with Chi square test with level of significanceр<0.05. From the analyzis and interpretationof the results we can see that personswith Broca’s aphasia, although produce incompletesentences, they verbalise sentences withcontent which are informative for their interlocutorand the auditory understending is less demagedthan the expressive funcion of the speech.In conclusion, the study found that earlyrehabilitation treatment using speech therapyfor persons with Broca’s aphasia resulted infaster improvements and better capabilities forspeech-language communicational skills.
Yu, Xiao-Dan; Jiang, Chao; Huang, Lu-Qi; Qin, Shuang-Shuang; Zeng, Xiang-Mei; Chen, Ping; Yuan, Yuan
To clone SABATH methyltransferase (rLjSABATHMT) gene in Lonicera japonica var. chinensis, and compare the gene expression and intron sequence of SABATH methyltransferase orthologous in L. japonica with L. japonica var. chinensis. It provide a basis for gene regulate the formation of L. japonica floral scents. The cDNA and genome sequences of LjSABATHMT from L. japonica var. chinensis were cloned according to the gene fragments in cDNA library. The LjSABATHMT protein was characterized by bioinformatics analysis. SABATH family phylogenetic tree were built by MEGA 5.0. The transcripted level of SABATHMT orthologous were analyzed in different organs and different flower periods of L. japonica and L. japonica var. chinensis using RT-PCR analysis. Intron sequences of SABATHMT orthologous were also analyzied. The cDNA of LjSABATHMT was 1 251 bp, had a complete coding frame with 365 amino acids. The protein had the conservative SABATHMT domain, and phylogenetic tree showed that it may be a salicylic acid/benzoic acid methyltransferase. Higher expression of SABATH methyltransferase orthologous was found in flower. The intron sequence of L. japonica and L. japonica var. chinensis had rich polymorphism, and two SNP are unique genotype of L. japonica var. chinensis. The motif elements in two orthologous genes were significant differences. The intron difference of SABATH methyltransferase orthologous could be inducing to difference of gene expression between L. japonica and L. japonica var. chinensis. These results will provide important base on regulating active compounds of L. japonica.
Full Text Available Clustering is a popular technique for explorative analysis of data, as it can reveal subgroupings and similarities between data in an unsupervised manner. While clustering is routinely applied to gene expression data, there is a lack of appropriate general methodology for clustering of sequence-level genomic and epigenomic data, e.g. ChIP-based data. We here introduce a general methodology for clustering data sets of coordinates relative to a genome assembly, i.e. genomic tracks. By defining appropriate feature extraction approaches and similarity measures, we allow biologically meaningful clustering to be performed for genomic tracks using standard clustering algorithms. An implementation of the methodology is provided through a tool, ClusTrack, which allows fine-tuned clustering analyses to be specified through a web-based interface. We apply our methods to the clustering of occupancy of the H3K4me1 histone modification in samples from a range of different cell types. The majority of samples form meaningful subclusters, confirming that the definitions of features and similarity capture biological, rather than technical, variation between the genomic tracks. Input data and results are available, and can be reproduced, through a Galaxy Pages document at http://hyperbrowser.uio.no/hb/u/hb-superuser/p/clustrack. The clustering functionality is available as a Galaxy tool, under the menu option "Specialized analyzis of tracks", and the submenu option "Cluster tracks based on genome level similarity", at the Genomic HyperBrowser server: http://hyperbrowser.uio.no/hb/.
Widya Novia Hedyanti
Full Text Available Family has a very important contribution to education because the family is the first and foremost in the world of early childhood education and continuing education of children. Appropriate care will motivate children to obtain optimal learning achievement. This type of research is ex post facto. The sample was 123 students in five schools that are members of the Cluster 2 Ngantang. Data were collected using a questionnaire as an instrument of variable patterns of parenting and motivation to learn., While learning outcomes are from the daily tests. The results of the questionnaire will be analyzed using path analysis and assisted with SPSS for Windows version 23. The results of data analysis showed that 1 There is a significant direct effect between parenting on the learning achievement of children and parenting on children learning motivation, 2 There is a significant direct effect between student’s motivation to IPS student achievement; 3 There is no direct influence between parenting on student achievement through learning motivation. Variable motivation to strengthen the direct influence of parenting on learning achievement IPS students. Keluarga memiliki kontribusi yang sangat penting terhadap dunia pendidikan karena keluarga merupakan orang yang pertama dan utama dalam dunia pendidikan awal anak dan kelanjutan pendidikan anak. Pengasuhan yang tepat akan memberikan motivasi pada anak untuk mendapatkan prestasi belajar yang optimal. Jenis penelitian ini adalah ex post facto. Sampel yang digunakan berjumlah 123 siswa di lima sekolah yang tergabung dalam Gugus 2 Kecamatan Ngantang. Data dikumpulkan dengan menggunakan angket sebagai instrumen dari variabel pola asuh orangtua dan motivasi belajar., sedangkan hasil belajar diambil dari nilai ulangan harian. Hasil dari angket akan dianalisis dengan menggunakan analisis jalur (path analyzis dan dibantu dengan SPSS for windows versi 23. Hasil analisis data menunjukkan bahwa 1 Terdapat pengaruh
Romilson Cesar Lima
Full Text Available A educação é considerada uma importante fonte de transformação do ser social. Provocações e novos desafios surgem a cada dia em busca de analisarmos se estamos atuando ou não de forma moral e ética. A sustentabilidade e o consumismo são características bem opostas, de um lado empresas que primam pelo progresso, oferecem vagas de empregos e beneficiam seres humanos com suas atividades, do outro, uma nova educação, dotada de preocupações com a preservação ambiental. Considerado um dos assuntos mais comentados na atualidade, a educação para sustentabilidade está intrinsecamente ligada à solidariedade, respeito e afetividade e precisa estar conectada a três pilares: prosperidade econômica, respeito ao meio ambiente e proteção social. Para isto, é necessário que as pessoas substituam o pensamento capitalista consumista, mantendo a sustentabilidade. Esta pesquisa teve o objetivo de identificar acontecimentos atuais provocados por uma mineradora no município de São João da Boa Vista e o quanto a conscientização pela Educação para a Sustentabilidade pode proporcionar para a localidade e humanidade. Investigouse a Lei Orgânica e Legislação Municipal a fim de evitarem a ação da mineradora e manter, sem maiores danos, o turismo local e regional. Education is considered an important source of transformation of social being. Provocations and new challenges arise every day in order to analyzy whether or not we are acting with morals and ethics. Sustainability and consumerism are quite opposite characteristics on the one hand companies that strive for progress, offer job openings a new education, endowed with concerns over environmental preservation. Considered as one of the most discussed subjects currently, education for sustainability is intrinsically linked to solidarity, respect and affection and has to be connected to three pillars: economic prosperity, environmental respect and social protection. To achieve this
A realização do teste anti-hiv no pré-natal: os significados para a gestante El establecimiento de la lucha contra la prueba del vih en pre-navidad: significados para el embarazo The establishment of anti-hiv test in pre-natal: meanings for pregnancy
Roberta Maria de Oliveira Silva
parte de la construcción del papel maternal de un cuidado bien-tomado del concreto con la salud del bebé.The study had as objective, the knowledge and the analyzis of the meaning of the accomplishment for the test anti-HIV in the prenatal one for the pregnant women. One is about a research with qualitative approach and was carried through in a Hospital School and a Maternity at the city of Rio de Janeiro. As a resource of technician-methodological, the speech of the collective citizen was used (DSC. After the analysis of the speeches we verified that, for the pregnant women the accomplishment of the test means the possibility to prevent the vertical transmission of the HIV and as part of the prenatal assistance. The prenatal one was considered by the pregnant women an excellent chance for the accomplishment of the test anti HIV, for the knowledge of the serological condition and precocious beginning of the treatment. It is concluded that the test, for the majority of the pregnant women, represents the possibility to protect the son of the HIV, beyond being part of the construction of the maternal paper from a well-taken care of concrete with the health of the baby.
Alta hospitalar e o cuidado do recém-nascido prematuro no domicílio: vivência materna Alta hospitalaria y el cuidado de los recién-nacidos prematuros en el hogar: experiencias de la madre Hospital and care of the premature newborn at home: maternal experiences
Mirna Albuquerque Frota
ía acerca del cuidado con el bebé después del alta, reforzando que las madres llevan al bebé a la casa sin estar preparadas para la nueva realidad.It aimed at learning about the mother's perception in a hospital and the care of premature newborns at home after the first week of discharge. Descriptive, qualitative approach, using semi-structured interviews to collect data, developed in the outpatient follow-up of premature (Follow up of the State Public Hospital Network of Fortaleza, in October and November 2011. The participants were nine mothers of preterm infants after the first week of discharge. It was applied the analyzis the content for data analysis. The results pointed to the categories: Guidelines on the care of premature infants during discharge; feelings and difficulties with the baby's arrival at home; family support in the care of premature infants. The study showed that some mothers were not instructed interdisciplinary team of neonatology care about the baby after discharge, stressing that they take the baby to the household without being prepared for the new reality.
collected observation, interview, and documentation. The procedure of the research were pre-court stage, field work stage and data analysis stage. The data were analyzied by data collection, data reduction, data presentation, and drawing conclusions.The result of the study showed that the archives management include the record, control and distribution of archive, archival storage, archive maintenance, archive monitoring, archive removal and destruction. The problem of the study is there are still archives that accumulate in the archives storage depos space, there is no of sanctions for borrowers who are late return.Based on the result on this study it can be concluded that the recording archive through archive complete, control and distribution of the data received, date of letter, initials of the recipient. System archive storage that is used system chronological (date, maintenance with cleaning every corner of the archive room either with a duster or broom and give camphor in the shelf filling also coat archive with cover paper, removal and destruction of archive conducted by periodic or once a year. Thus, it is recommended: 1 optimize the storage depot space that archive are still stacked and unprocessed, 2 give sanction the borrowers that return the archive not in time
Comparação de kits ELISA® comerciais para anticorpos no soro e leite com um teste coproparasitológico em bovinos naturalmente infectados por Fasciola hepatica Comparison of comercial® ELISA kits for antibodies in serum and milk with a fecal test in cattle naturally infected with Fasciola hepatica
Cíntia das C. Bernardo
Full Text Available A fasciolose é uma enfermidade causada por um trematoda que acomete o fígado principalmente de ruminantes domésticos, podendo parasitar o homem e seu diagnóstico é realizado rotineiramente por exames coproparasitológicos. O objetivo do presente estudo foi comparar kits comerciais de ELISA para anticorpos no soro e leite com um teste coproprarasitológico em bovinos naturalmente infectados por Fasciola hepatica. Foram coletadas amostras de fezes (92 sangue (92 e leite (43 de bovinos provenientes de propriedades de gado leiteiro do município de Jerônimo Monteiro, sul do Estado do Espírito Santo. As amostras de fezes coletadas foram processadas pela técnica de sedimentação fecal para ovos de F. hepatica, utilizada como padrão ouro para as análises. Amostras de sangue e de leite foram processadas segundo a orientação do fabricante dos respectivos Kits ELISA comerciais testados. Utilizou-se o c² de McNemar para comparação estatística e calcularam-se a sensibilidade e especificidade, valores preditivos e kappa. Os resultados obtidos mostraram que as frequências de positividade pelo uso dos kits ELISA comerciais de soro e de leite diferiram significativamente (pThe fascioliasis is a disease caused by a trematode that affects the liver mainly of domestic ruminants and can also parasite man; its diagnosis is routinely done by coprological methods. The aim of this study was to compare commercial ELISA kits for antibodies in serum and milk with a coprological test in cattle naturally infected by Fasciola hepatica. We collected fecal, blood and milk samples from cattle in the municipality of Jerônimo Monteiro, southern Espírito Santo state. The fecal samples were processed by the fecal egg sedimentation for F. hepatica, which is used as a gold standard for analyzis. Blood (92 and milk (43 samples were processed according to the manufacturer instructions of the respective commercial ELISA kits tested. We used the McNemar chi-square for
Eliane Viana Mancuzo
evolution of hematopoietic stem cell transplantation receptors.The objective of this study is to review the most frequent non-infection complications associated to hematopoietic stem cell transplantation since the first bone marrow transplantation performed in 1957.A systematic literature review was performed, using the PICO strategy to ask the questions. The descriptors hematopoietic stem cell transplantation, non-infectious pulmonary complications, systematic review, in portuguese and their english correspondents, were used to access the following databases: MEDLINE, EBM, Embase, Cocrane Library, LILACS and SciELO. In this review, 263 studies were identified, from which 31 were selected for full analyzis.The non-infection pulmonary complications most frequently found were: bronchiolitis obliterans, bronchiolitis obliterans organizing pneumonia, pulmonary edema, idiopathic pneumonia syndrome, delayed pulmonary toxicity syndrome, diffuse alveolar hemorrhage, engrafment syndrome and pulmonary cytolitic thrombi.Rev Port Pneumol 2010; XVI (5: 815-828 Palavras-chave: Transplante de células-tronco hematopoiéticas, complicações pulmonares não infecciosas, revisão sistemática, Key-words: Hematopoietic stem cell transplantation, non-infectious pulmonary complications, systematic review
Emprego de soluções adocicadas no alívio da dor neonatal em recém-nascido prematuro: uma revisão integrativa Empleo de soluciones edulcoradas en el manejo del dolor neonatal en recién nacido prematuro: una revisión integrativa Use of sweet solutions for neonatal pain relief in premature newborns: an integrative review
Caroline de Oliveira Alves
de la salud.The repeated painful experiences in newborns may have short- and long-time effects, especially in premature infants. The use of sweetened solutions during painful procedures has been recommended as a measure of pain relief. This study aims to evaluate the evidence of the effect of oral sucrose or glucose for acute pain relief in premature infants. An integrative review was conducted in the MEDLINE and LILACS databases. Eight articles were selected from 2005 to 2010. The analyzis of these articles revealed the analgesic effect of glucose and sucrose in acute procedures. No significant side effects were found in infants who received glucose/sucrose. We emphasize the importance of the use of the pain assessment scale most closely related to the predominant population in the Neonatal Intensive Care Unit, a scale easy to be used and handled by health professionals.
A influência do anel na evolução ponderal após quatro anos da derivação gástrica em y-de-roux laparoscópica Ring influence on ponderal evolution after four years of laparoscopic Roux-en-Y gastric bypass
ção do anel ao se analisar exclusivamente a perda de peso.BACKGROUND: Use of ring in Roux-en-Y gastric bypass is still a matter of controversy among bariatric surgeons. There is no consensus on its impact in relation to weight loss and weight maintenance in the long term. AIM: To evaluate the influence of the ring on the evolution of body weight over four years after bariatric surgery. METHODS: Retrospective analyzis of 143 women who underwent laparoscopic Roux-en-Y gastric bypass paired on the use or not use of Silastic® ring. Follow-up time was 48 months. Inclusion criteria were age over 18 years, primary bariatric operation and regular attendance at the clinic during the period of interest for research. The technique kept small gastric reservoir estimated in a volume of 30 ml. The food limb had in average 150 cm and the bile one 40 cm from the duodenojejunal angle. The group "ring" used Silastic® device with length of 6.5 cm, placed 2 cm from gastrojejunal anastomosis. The ring was closed for five polypropylene surgical thread sutures. In the morning after surgery the patients received isotonic fluids; on the second day salty liquid diet and were discharged on the third day. Semisolid diet started from the 20th day and solid on the 30th, with daily tablet of polivitamins. RESULTS: The weight loss was larger on the ring than without ring groups in all periods, respectively 10% and only 5% in the third postoperative year. The proportion of not having reached the 50% excess weight loss expectative was significantly higher in the group without ring than in the group with the ring (31% and 8% respectively in the fourth year. There was no difference between groups in delayed recovery of weight lost with the operation. CONCLUSIONS: The results were favorable to use the ring exclusively when it is analyzed only the weight loss.