Sample records for analytic receiver analysis

  1. Performance Evaluation of Linear Turbo-Receivers Using Analytical Extrinsic Information Transfer Functions

    Directory of Open Access Journals (Sweden)

    Leszek Szczeciński


    Full Text Available Turbo-receivers reduce the effect of the interference-limited propagation channels through the iterative exchange of information between the front-end receiver and the channel decoder. Such an iterative (turbo process is difficult to describe in a closed form so the performance evaluation is often done by means of extensive numerical simulations. Analytical methods for performance evaluation have also been proposed in the literature, based on Gaussian approximation of the output of the linear signal combiner. In this paper, we propose to use mutual information to parameterize the logarithmic-likelihood ratios (LLRs at the input/output of the decoder, casting our approach into the framework of extrinsic information transfer (EXIT analysis. We find the EXIT functions of the front-end (FE receiver analytically, that is, using solely the information about the channel state. This is done, decomposing the FE receiver into elementary blocks described independently. Our method gives an insight into the principle of functioning of the linear turbo-receivers, allows for an accurate calculation of the expected bit error rate in each iteration, and is more flexible than the one previously used in the literature, allowing us to analyze the performance for various FE structures. We compare the proposed analytical method with the results of simulated data transmission in case of multiple antennas transceivers.

  2. Exploratory Analysis in Learning Analytics (United States)

    Gibson, David; de Freitas, Sara


    This article summarizes the methods, observations, challenges and implications for exploratory analysis drawn from two learning analytics research projects. The cases include an analysis of a games-based virtual performance assessment and an analysis of data from 52,000 students over a 5-year period at a large Australian university. The complex…

  3. Double-contained receiver tank 244-TX, grab samples, 244TX-97-3 analytical results for the final report

    Energy Technology Data Exchange (ETDEWEB)

    Esch, R.A.


    This document is the final report for the double-contained receiver tank (DCRT) 244-TX grab samples. Three grabs samples were collected from riser 8 on May 29, 1997. Analyses were performed in accordance with the Compatibility Grab Sampling and Analysis Plan (TSAP) and the Data Quality Objectives for Tank Farms Waste Compatibility Program (DQO). The analytical results are presented in a table.

  4. Analysis of the omnium-g receiver

    Energy Technology Data Exchange (ETDEWEB)

    Bohn, M.


    A thermal analysis of the Omnium-G receiver is presented and the technique is shown to be generally applicable to solar thermal receivers utilizing a directly heated thermal mass. The thermal loss coefficient, including reradiation losses, is calculated and shown to agree quite well with the experimentally measured thermal loss coefficient. The rate of heat transfer to the working fluid is also analyzed and the analysis is used to show that the Omnium-G receiver is well matched to the water/steam working fluid because the steam outlet temperature is almost the same as the receiver temperature. A general procedure for calculating receiver performance is presented. With this procedure, the energy delivery to any working fluid, the delivered temperature of the working fluid, and the pressure drop through the receiver can be determined. An example of the calculation is also presented.

  5. Unified analytical expressions for calculating resonant frequencies, transimpedances, and equivalent input noise current densities of tuned receiver front ends



    Unified analytical expressions have been derived for calculating the resonant frequencies, transimpedance and equivalent input noise current densities of the four most widely used tuned optical receiver front ends built with FETs and p-i-n diodes. A more accurate FET model has been used to improve the accuracy of the analysis. The Miller capacitance has been taken into account, and its impact on the performances of the tuned front ends has been demonstrated. The accuracy of the expressions ha...

  6. A Behavior Level Analytical Method of Electromagnetic Susceptibility for Radio Frequency Receiver

    Institute of Scientific and Technical Information of China (English)

    YAN Zhaowen; YU Xiaofeng; XIE Shuguo; LIU Yan


    Based on simplified Volterra model, a behavior-level simulation analysis approach of electromagnetic susceptibility (EMS) for radio frequency (RF) receiver is presented in this article. Third order simplified Volterra model is adopted to analyze receiver EMS. A general criterion for EMS is proposed according to EMS response characteristics in frequency domain, and then the simulation flow charts for calculating susceptibility thresholds are given. This approach is superior to the previous EMS analysis method on receiver, which mainly relies on experiments but lack simulation analysis. Take the dual frequency GPS receiver and zero IF receiver interfered by continue wave as examples for in-band and out-of-band susceptibility threshold calculation. Simulation results show that the proposed method is not only valid and effective, but also reduces the internal storage and simulation time, which is suitable to RF receiver EMS analysis and practical in engineering and technology field.

  7. Analytical estimation of laser phase noise induced BER floor in coherent receiver with digital signal processing. (United States)

    Vanin, Evgeny; Jacobsen, Gunnar


    The Bit-Error-Ratio (BER) floor caused by the laser phase noise in the optical fiber communication system with differential quadrature phase shift keying (DQPSK) and coherent detection followed by digital signal processing (DSP) is analytically evaluated. An in-phase and quadrature (I&Q) receiver with a carrier phase recovery using DSP is considered. The carrier phase recovery is based on a phase estimation of a finite sum (block) of the signal samples raised to the power of four and the phase unwrapping at transitions between blocks. It is demonstrated that errors generated at block transitions cause the dominating contribution to the system BER floor when the impact of the additive noise is negligibly small in comparison with the effect of the laser phase noise. Even the BER floor in the case when the phase unwrapping is omitted is analytically derived and applied to emphasize the crucial importance of this signal processing operation. The analytical results are verified by full Monte Carlo simulations. The BER for another type of DQPSK receiver operation, which is based on differential phase detection, is also obtained in the analytical form using the principle of conditional probability. The principle of conditional probability is justified in the case of differential phase detection due to statistical independency of the laser phase noise induced signal phase error and the additive noise contributions. Based on the achieved analytical results the laser linewidth tolerance is calculated for different system cases.

  8. Analysis of signal acquisition in GPS receiver software

    Directory of Open Access Journals (Sweden)

    Vlada S. Sokolović


    . the whole receiver is software implemented in a MATLAB software package. One of the processes during the signal processing is the initial synchronization (acquisition, where a signal is detected and the carrier frequency is determined as well as the phase sequence code and the carrier Doppler frequency. The acquisition aim is to determine, in the shortest time possible, the parameters of the detected signals and forward them to the next block in synchronization. Depending on the speed and accuracy of the signal parameter determination, different methods of acquisition are applied in practice. The paper presents the methods of serial, parallel and cyclic convolution. For comparison purposes, the architectures of signal processing of particular methods for implementation in receiver software are shown. All measurements were performed on the same signal under the same conditions. On the basis of the tests performed, a detailed analysis of the collected data was carried out and the most acceptable acquisition method for implementation in software GPS receiver was proposed. Because of a relatively high level of noise at the receiver entrance and the received signal interference, the comparison of the results has been done on the basis of the analytical results and the mean time of signal synchronization. The measurement results are shown in tables for easy comparison. The results of measurements using the proposed method are presented as well. The technology of receiver software allows the user to access easily to the architecture of the receiver and therefore allows a simple change of parameters. The influence of the parameters on the process of signal acquisition is also shown in the paper. The graphic presentation shows how and to what extent some of the parameters affect the process of the receiver signal processing. All listed acquisition methods are used in practice. The proposed method is the most suitable for application in software receivers. Based on the analysis

  9. Phenol Analysis -- Some Analytical Considerations (United States)

    Starkey, R. J., Jr.


    Contamination of potable water supplies with halogenated phenols in concentrations of 2-10 parts per billion (ppb) produces objectionable tastes and odors capable of influencing consumer acceptability. Routine analysis by the distillation/ 4-aminoantipyrine method is limited by lack of sensitivity and subject to interference by aryl amines. This has been overcome by developing a continuous liquid-liquid extraction system to selectively isolate phenols and eliminate major interfering substances. Stable reagents have been formulated to reduce blank color and extend sensitivity. Equipment suitable for analysis of phenols at the 1 ppb level or less in 20 minutes is described.

  10. Analytical techniques in pharmaceutical analysis: A review

    Directory of Open Access Journals (Sweden)

    Masoom Raza Siddiqui


    Full Text Available The development of the pharmaceuticals brought a revolution in human health. These pharmaceuticals would serve their intent only if they are free from impurities and are administered in an appropriate amount. To make drugs serve their purpose various chemical and instrumental methods were developed at regular intervals which are involved in the estimation of drugs. These pharmaceuticals may develop impurities at various stages of their development, transportation and storage which makes the pharmaceutical risky to be administered thus they must be detected and quantitated. For this analytical instrumentation and methods play an important role. This review highlights the role of the analytical instrumentation and the analytical methods in assessing the quality of the drugs. The review highlights a variety of analytical techniques such as titrimetric, chromatographic, spectroscopic, electrophoretic, and electrochemical and their corresponding methods that have been applied in the analysis of pharmaceuticals.


    Energy Technology Data Exchange (ETDEWEB)

    Reigel, M.; Best, D.


    The Mixed Oxide Fuel Fabrication Facility (MFFF) will use colemanite bearing concrete neutron absorber panels credited with attenuating neutron flux in the criticality design analyses and shielding operators from radiation. The Savannah River National Laboratory (SRNL) is tasked with measuring the boron oxide content of the colemanite raw aggregate material prior to it being mixed into the concrete. SRNL received ten samples of colemanite for analysis on July 22, 2013. The elemental boron content of each sample was measured according to ASTM C 1301. The boron oxide content was calculated using the oxide conversion factor for boron.

  12. Unified analytical expressions for calculating resonant frequencies, transimpedances, and equivalent input noise current densities of tuned receiver front ends

    DEFF Research Database (Denmark)

    Liu, Qing Zhong


    Unified analytical expressions have been derived for calculating the resonant frequencies, transimpedance and equivalent input noise current densities of the four most widely used tuned optical receiver front ends built with FETs and p-i-n diodes. A more accurate FET model has been used to improve...

  13. Asymmetric Hardware Distortions in Receive Diversity Systems: Outage Performance Analysis

    KAUST Repository

    Javed, Sidrah


    This paper studies the impact of asymmetric hardware distortion (HWD) on the performance of receive diversity systems using linear and switched combining receivers. The asymmetric attribute of the proposed model motivates the employment of improper Gaussian signaling (IGS) scheme rather than the traditional proper Gaussian signaling (PGS) scheme. The achievable rate performance is analyzed for the ideal and non-ideal hardware scenarios using PGS and IGS transmission schemes for different combining receivers. In addition, the IGS statistical characteristics are optimized to maximize the achievable rate performance. Moreover, the outage probability performance of the receive diversity systems is analyzed yielding closed form expressions for both PGS and IGS based transmission schemes. HWD systems that employ IGS is proven to efficiently combat the self interference caused by the HWD. Furthermore, the obtained analytic expressions are validated through Monte-Carlo simulations. Eventually, non-ideal hardware transceivers degradation and IGS scheme acquired compensation are quantified through suitable numerical results.

  14. Prediction and optimization of the performance of parabolic solar dish concentrator with sphere receiver using analytical function

    CERN Document Server

    Huang, Weidong; Hu, Peng; Chen, Zeshao


    Parabolic solar dish concentrator with sphere receiver is less studied. We present an analytic function to calculate the intercept factor of the system with real sun bright distribution and Gaussian distribution, the results indicate that the intercept factor is related to the rim angle of reflector and the ratio of open angle of receiver at the top of reflector to optical error when the optical error is larger than or equal to 5 mrad, but is related to the rim angle, open angle and optical error in less than 5 mrad optical error. Furthermore we propose a quick process to optimize the system to provide the maximum solar energy to net heat efficiency for different optical error under typical condition. The results indicate that the parabolic solar dish concentrator with sphere receiver has rather high solar energy to net heat efficiency which is 20% more than solar trough and tower system including higher cosine factor and lower heat loss of the receiver.

  15. Comparison of analytical eddy current models using principal components analysis (United States)

    Contant, S.; Luloff, M.; Morelli, J.; Krause, T. W.


    Monitoring the gap between the pressure tube (PT) and the calandria tube (CT) in CANDU® fuel channels is essential, as contact between the two tubes can lead to delayed hydride cracking of the pressure tube. Multifrequency transmit-receive eddy current non-destructive evaluation is used to determine this gap, as this method has different depths of penetration and variable sensitivity to noise, unlike single frequency eddy current non-destructive evaluation. An Analytical model based on the Dodd and Deeds solutions, and a second model that accounts for normal and lossy self-inductances, and a non-coaxial pickup coil, are examined for representing the response of an eddy current transmit-receive probe when considering factors that affect the gap response, such as pressure tube wall thickness and pressure tube resistivity. The multifrequency model data was analyzed using principal components analysis (PCA), a statistical method used to reduce the data set into a data set of fewer variables. The results of the PCA of the analytical models were then compared to PCA performed on a previously obtained experimental data set. The models gave similar results under variable PT wall thickness conditions, but the non-coaxial coil model, which accounts for self-inductive losses, performed significantly better than the Dodd and Deeds model under variable resistivity conditions.

  16. Guided text analysis using adaptive visual analytics (United States)

    Steed, Chad A.; Symons, Christopher T.; DeNap, Frank A.; Potok, Thomas E.


    This paper demonstrates the promise of augmenting interactive visualizations with semi-supervised machine learning techniques to improve the discovery of significant associations and insight in the search and analysis of textual information. More specifically, we have developed a system-called Gryffin-that hosts a unique collection of techniques that facilitate individualized investigative search pertaining to an ever-changing set of analytical questions over an indexed collection of open-source publications related to national infrastructure. The Gryffin client hosts dynamic displays of the search results via focus+context record listings, temporal timelines, term-frequency views, and multiple coordinated views. Furthermore, as the analyst interacts with the display, the interactions are recorded and used to label the search records. These labeled records are then used to drive semi-supervised machine learning algorithms that re-rank the unlabeled search records such that potentially relevant records are moved to the top of the record listing. Gryffin is described in the context of the daily tasks encountered at the Department of Homeland Security's Fusion Centers, with whom we are collaborating in its development. The resulting system is capable of addressing the analysts information overload that can be directly attributed to the deluge of information that must be addressed in search and investigative analysis of textual information.

  17. Finite Element Analysis of the LOLA Receiver Telescope Lens (United States)

    Matzinger, Elizabeth


    This paper presents the finite element stress and distortion analysis completed on the Receiver Telescope lens of the Lunar Orbiter Laser Altimeter (LOLA). LOLA is one of six instruments on the Lunar Reconnaissance Orbiter (LRO), scheduled to launch in 2008. LOLA's main objective is to produce a high-resolution global lunar topographic model to aid in safe landings and enhance surface mobility in future exploration missions. The Receiver Telescope captures the laser pulses transmitted through a diffractive optical element (DOE) and reflected off the lunar surface. The largest lens of the Receiver Telescope, Lens 1, is a 150 mm diameter aspheric lens originally designed to be made of BK7 glass. The finite element model of the Receiver Telescope Lens 1 is comprised of solid elements and constrained in a manner consistent with the behavior of the mounting configuration of the Receiver Telescope tube. Twenty-one temperature load cases were mapped to the nodes based on thermal analysis completed by LOLA's lead thermal analyst, and loads were applied to simulate the preload applied from the ring flexure. The thermal environment of the baseline design (uncoated BK7 lens with no baffle) produces large radial and axial gradients in the lens. These large gradients create internal stresses that may lead to part failure, as well as significant bending that degrades optical performance. The high stresses and large distortions shown in the analysis precipitated a design change from BK7 glass to sapphire.

  18. Analytic standard errors for exploratory process factor analysis. (United States)

    Zhang, Guangjian; Browne, Michael W; Ong, Anthony D; Chow, Sy Miin


    Exploratory process factor analysis (EPFA) is a data-driven latent variable model for multivariate time series. This article presents analytic standard errors for EPFA. Unlike standard errors for exploratory factor analysis with independent data, the analytic standard errors for EPFA take into account the time dependency in time series data. In addition, factor rotation is treated as the imposition of equality constraints on model parameters. Properties of the analytic standard errors are demonstrated using empirical and simulated data.

  19. Correlation analysis between ionospheric scintillation levels and receiver tracking performance (United States)

    Sreeja, V.; Aquino, M.; Elmas, Z. G.; Forte, B.


    Rapid fluctuations in the amplitude and phase of a transionospheric radio signal caused by small scale plasma density irregularities in the ionosphere are known as scintillation. Scintillation can seriously impair a GNSS (Global Navigation Satellite Systems) receiver tracking performance, thus affecting the required levels of availability, accuracy and integrity, and consequently the reliability of modern day GNSS based applications. This paper presents an analysis of correlation between scintillation levels and tracking performance of a GNSS receiver for GPS L1C/A, L2C and GLONASS L1, L2 signals. The analyses make use of data recorded over Presidente Prudente (22.1°S, 51.4°W, dip latitude ˜12.3°S) in Brazil, a location close to the Equatorial Ionisation Anomaly (EIA) crest in Latin America. The study presents for the first time this type of correlation analysis for GPS L2C and GLONASS L1, L2 signals. The scintillation levels are defined by the amplitude scintillation index, S4 and the receiver tracking performance is evaluated by the phase tracking jitter. Both S4 and the phase tracking jitter are estimated from the post correlation In-Phase (I) and Quadra-Phase (Q) components logged by the receiver at a high rate. Results reveal that the dependence of the phase tracking jitter on the scintillation levels can be represented by a quadratic fit for the signals. The results presented in this paper are of importance to GNSS users, especially in view of the forthcoming high phase of solar cycle 24 (predicted for 2013).

  20. The Cycle of Warfare - Analysis of an Analytical Model

    DEFF Research Database (Denmark)

    Jensen, Mikkel Storm


    The abstract has the title: “The Cycle of Warfare - Analysis of an Analytical Model” The Cycle of Warfare is an analytical model designed to illustrate the coherence between the organization, doctrine and technology of a military entity and the influence of the surrounding society as expressed...

  1. Securitization of Receivables - An Analysis of the Inherent Risks

    Directory of Open Access Journals (Sweden)

    José Roberto Ferreira Savoia


    Full Text Available Securitization is a modality of structured finance which allows a company to raise funds based on its receivables through capital markets. In Brazil, securitization was developed mostly in the form of mutual funds - the FIDC, which raise money by issuing senior cotes for qualified investors, and subordinated cotes, usually bought by the company that originated the receivables. This paper evaluates the risk and return for both kinds of investors through a stochastic model with two main variables: interest rates and default rates. The model is still sensible to the characteristics of the fund, like the amount of subordinated cotes, the type of asset being securitized; and the amount of receivables in relation to the assets. Regarding the case of senior cotes, the risk of returns under the basic level of interest rates is highly improbable; and in the case of subordinated cotes, the risk of returns under the basic interest rate may be considered still low, due to the high spreads observed in the Brazilian financial market. The simulations indicated that under historically mean interest rate volatility the default rates are the main component of the total risk. Accordingly to the developed analysis of international standards of regulation, the Brazilian Central Bank imposes very strong capital requirements to banks that securitize their assets and purchase the corresponding subordinated cotes.


    Directory of Open Access Journals (Sweden)

    Kamil Pluta


    Full Text Available Reducing waste water discharges to the receiver is now one of the most important activities to ensure the protection of surface waters. This is caused mainly by progressive urbanization and increasing impervious surfaces. Discharge of sewage with a large load of pollutants affect the receivers in a negative way. The quality of waste water varies and depends on many factors, but above all, it is closely linked with sewer system applied to the drainage catchment. The article presents a comparative analysis of the environmental impact of three basic sewer systems: combined, separate and semi-separate. The analysis was performed for a typical urban catchment, using the average concentration of the basic indicators of pollution, which total suspended solids, nitrogen and phosphorus, COD, BOD5, selected heavy metals are merked. The results concluded that each of these sewer systems characterized by varying environmental impacts depending on the indicator of pollution. The best of today available technical solutions seem to be semi-separate sewer system, using the storage tank with the control in real time (RTC for controlling the flow.

  3. Summative Mass Analysis of Algal Biomass - Integration of Analytical Procedures: Laboratory Analytical Procedure (LAP)

    Energy Technology Data Exchange (ETDEWEB)

    Laurens, L. M. L.


    This procedure guides the integration of laboratory analytical procedures to measure algal biomass constituents in an unambiguous manner and ultimately achieve mass balance closure for algal biomass samples. Many of these methods build on years of research in algal biomass analysis.

  4. Correlated Data Analysis Modeling, Analytics, and Applications

    CERN Document Server

    Song, Peter X-K


    Presents developments in correlated data analysis. This book provides a systematic treatment for the topic of estimating functions. In addition to marginal models and mixed-effects models, it covers topics on joint regression analysis based on Gaussian copulas and generalized state space models for longitudinal data from long time series.

  5. Analytical Analysis of Generic Reusabilty: Weyukers Properties

    Directory of Open Access Journals (Sweden)

    Parul Gandhi


    Full Text Available Reusability is the key concept in todays software development environment. The concept of reusability can be achieved by Generic programming approach. C++ templates help us to develop generic code which results in reusable software modules and also identify effectiveness of this reuse strategy. Many researchers have already developed various reusability metrics [9] [7]. In this paper we emphasis on evaluating reusability metrics on weyukers set of properties. Weyukers list of properties has always been a point of reference and suggested as a guiding tool in identification of a good complexity measure by several researchers. We have chosen some recently reported reusability metrics Method Template Inheritance Factor (MTIF and Attribute Template Inheritance factor (ATIF and evaluated them against Weyukers set of principles. We divide our work in a two-step framework. In the first step the metrics are analytically evaluated against a formal list of Weyukers properties and in the second step we calculate LOC metric value by using three different programs designed using template and inheritance features of object-oriented programming and observe that by using template with inheritance property we can reduce number of lines of a project to a great extent.

  6. Monobit Digital Receivers for QPSK: Design, Analysis and Performance

    CERN Document Server

    Wang, Zhiyong; Zhang, Wenyi; Wei, Guo


    Future communication system requires large bandwidth to achieve high data rate up to multigigabit/ sec, which makes analog-to-digital (ADC) become a key bottleneck for the implementation of digital receivers due to its high complexity and large power consumption. Therefore, monobit receivers for BPSK have been proposed to address this problem. In this work, QPSK modulation is considered for higher data rate. First, the optimal receiver based on monobit ADC with Nyquist sampling is derived, and its corresponding performance in the form of deflection ratio is calculated. Then a suboptimal but more practical monobit receiver is obtained, along with iterative demodulation and small sample removal. The effect of the imbalances between the In-phase (I) and Quadrature-phase (Q) branches, including the amplitude and phase imbalances, is carefully investigated too. To combat the performance loss caused by IQ imbalances, monobit receivers based on double training sequences are proposed. Numerical simulations show that ...

  7. Evaluation and Error Analysis for a Solar thermal Receiver

    Energy Technology Data Exchange (ETDEWEB)

    Pfander, M.


    In the following study a complete balance over the REFOS receiver module, mounted on the tower power plant CESA-1 at the Plataforma Solar de Almeria (PSA), is carried out. Additionally an error inspection of the various measurement techniques used in the REFOS project is made. Especially the flux measurement system Prohermes that is used to determine the total entry power of the receiver module and known as a major error source is analysed in detail. Simulations and experiments on the particular instruments are used to determine and quantify possible error sources. After discovering the origin of the errors they are reduced and included in the error calculation. the ultimate result is presented as an overall efficiency of the receiver module in dependence on the flux density at the receiver module's entry plane and the receiver operating temperature. (Author) 26 refs.

  8. Risk analysis of analytical validations by probabilistic modification of FMEA

    DEFF Research Database (Denmark)

    Barends, D.M.; Oldenhof, M.T.; Vredenbregt, M.J.


    Risk analysis is a valuable addition to validation of an analytical chemistry process, enabling not only detecting technical risks, but also risks related to human failures. Failure Mode and Effect Analysis (FMEA) can be applied, using a categorical risk scoring of the occurrence, detection...... and severity of failure modes, and calculating the Risk Priority Number (RPN) to select failure modes for correction. We propose a probabilistic modification of FMEA, replacing the categorical scoring of occurrence and detection by their estimated relative frequency and maintaining the categorical scoring...... of undetected failure mode(s) can be estimated quantitatively, for each individual failure mode, for a set of failure modes, and the full analytical procedure....

  9. Units of analysis in task-analytic research. (United States)

    Haring, T G; Kennedy, C H


    We develop and discuss four criteria for evaluating the appropriateness of units of analysis for task-analytic research and suggest potential alternatives to the units of analysis currently used. Of the six solutions discussed, the most commonly used unit of analysis in current behavior analytic work, percentage correct, meets only one of the four criteria. Five alternative units of analysis are presented and evaluated: (a) percentage of opportunities to perform meeting criterion, (b) trials to criteria, (c) cumulative competent performances, (d) percentage correct with competent performance coded, and (e) percentage correct with competent performance coded and a grid showing performance on individual steps of the task analysis. Of the solutions evaluated, only one--percentage correct with competent performance coded and a task analysis grid--met all four criteria.

  10. Risk analysis of analytical validations by probabilistic modification of FMEA. (United States)

    Barends, D M; Oldenhof, M T; Vredenbregt, M J; Nauta, M J


    Risk analysis is a valuable addition to validation of an analytical chemistry process, enabling not only detecting technical risks, but also risks related to human failures. Failure Mode and Effect Analysis (FMEA) can be applied, using a categorical risk scoring of the occurrence, detection and severity of failure modes, and calculating the Risk Priority Number (RPN) to select failure modes for correction. We propose a probabilistic modification of FMEA, replacing the categorical scoring of occurrence and detection by their estimated relative frequency and maintaining the categorical scoring of severity. In an example, the results of traditional FMEA of a Near Infrared (NIR) analytical procedure used for the screening of suspected counterfeited tablets are re-interpretated by this probabilistic modification of FMEA. Using this probabilistic modification of FMEA, the frequency of occurrence of undetected failure mode(s) can be estimated quantitatively, for each individual failure mode, for a set of failure modes, and the full analytical procedure.

  11. Performance analysis of underlay cognitive multihop regenerative relaying systems with multiple primary receivers

    KAUST Repository

    Hyadi, Amal


    Multihop relaying is an efficient strategy to improve the connectivity and extend the coverage area of secondary networks in underlay cognitive systems. In this work, we provide a comprehensive performance study of cognitive multihop regenerative relaying systems in an underlay spectrum sharing scenario with the presence of multiple primary receivers. Both interference power and peak power constraints are taken into account. In our analysis, all the links are subject to independent, non-identically distributed Nakagami-m fading. We derive closed-form expressions for the outage probability, high-order amount of fading, bit error rate, symbol error rate, and ergodic capacity. Different scenarios are presented to illustrate the obtained results and Monte Carlo simulations confirm the accuracy of our analytical derivations. © 2013 IEEE.

  12. Waste Analysis Plan for the Waste Receiving and Processing (WRAP) Facility

    Energy Technology Data Exchange (ETDEWEB)

    TRINER, G.C.


    The purpose of this waste analysis plan (WAP) is to document the waste acceptance process, sampling methodologies, analytical techniques, and overall processes that are undertaken for dangerous, mixed, and radioactive waste accepted for confirmation, nondestructive examination (NDE) and nondestructive assay (NDA), repackaging, certification, and/or storage at the Waste Receiving and Processing Facility (WRAP). Mixed and/or radioactive waste is treated at WRAP. WRAP is located in the 200 West Area of the Hanford Facility, Richland, Washington. Because dangerous waste does not include source, special nuclear, and by-product material components of mixed waste, radionuclides are not within the scope of this documentation. The information on radionuclides is provided only for general knowledge.

  13. Flow Injection Analysis: A Revolution in Modern Analytical Chemistry

    DEFF Research Database (Denmark)

    Hansen, Elo Harald


    A review is made of the fundamentals of Flow Injection Analysis (FIA), and the versatility and applicability of this analytical concept is demonstrated by a series of examples, comprizing the use of different types of FIA-manifolds and various detection devices (optical and electrochemical). Emph...

  14. Analytical and experimental analysis of tube coil heat exchanger (United States)

    Smusz, R.


    The paper presents the analytical and experimental analysis of heat transfer for the finned tube coil heat exchanger immersed in thermal storage tank. The tank is equipped with three helical-shaped heating coils and cylindrical- shaped stratification device. Two coils, upper and lower, use the water as a heating medium. The third, double wall heat exchanger coil, located at the bottom head on the tank is filled by the refrigerant (freon). Calculations of thermal power of water coil were made. Correlations of heat transfer coefficients in curved tubes were applied. In order to verify the analytical calculations the experimental studies of heat transfer characteristic for coil heat exchanger were performed.

  15. Central receiver power plant: an environmental, ecological, and socioeconomic analysis

    Energy Technology Data Exchange (ETDEWEB)

    Davison, M.; Grether, D.


    The technical details of the central receiver design are reviewed. Socio-economic questions are considered including: market penetration, air industrial sector model, demands on industry, employment, effluents associated with manufacture of components, strains due to intensive construction, water requirements, and land requirements. The ecological effects in the vicinity of the central receiver plant site are dealt with, with emphasis on effects on land surface, mammals, and reptiles and amphibians. Climatological considerations are reviewed including: desert types, effects of surface albedo modification, effects of aerosols, effects on evaporation rates, the heliostat canopy, effects on turbulent transfer rates, effects on the wind profile, a model of convection about a central receiver plant, and a global scenario. Drawings of heliostat and plant design are included in appendices. (MHR)

  16. Finite element method for thermal analysis of concentrating solar receivers


    Shtrakov, Stanko; Stoilov, Anton


    Application of finite element method and heat conductivity transfer model for calculation of temperature distribution in receiver for dish-Stirling concentrating solar system is described. The method yields discretized equations that are entirely local to the elements and provides complete geometric flexibility. A computer program solving the finite element method problem is created and great number of numerical experiments is carried out. Illustrative numerical results are given for an array...

  17. Analytical analysis of modulation instability in fiber optics

    Directory of Open Access Journals (Sweden)

    M. Saeed Aslam


    Full Text Available In this paper, an improved analysis for modulation instability, which results from interaction between optical wave and noise, is presented. It is shown that Nonlinear Schrodinger equation (NLSE, which governs this process, leads to the coupled wave equations that result to Riccati's differential equations. A completely analytical solution of Riccati's equation is obtained for small fiber length that results in efficient computation of the modulation instability effect.

  18. The performance analysis of linux networking - packet receiving

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Wenji; Crawford, Matt; Bowden, Mark; /Fermilab


    The computing models for High-Energy Physics experiments are becoming ever more globally distributed and grid-based, both for technical reasons (e.g., to place computational and data resources near each other and the demand) and for strategic reasons (e.g., to leverage equipment investments). To support such computing models, the network and end systems, computing and storage, face unprecedented challenges. One of the biggest challenges is to transfer scientific data sets--now in the multi-petabyte (10{sup 15} bytes) range and expected to grow to exabytes within a decade--reliably and efficiently among facilities and computation centers scattered around the world. Both the network and end systems should be able to provide the capabilities to support high bandwidth, sustained, end-to-end data transmission. Recent trends in technology are showing that although the raw transmission speeds used in networks are increasing rapidly, the rate of advancement of microprocessor technology has slowed down. Therefore, network protocol-processing overheads have risen sharply in comparison with the time spent in packet transmission, resulting in degraded throughput for networked applications. More and more, it is the network end system, instead of the network, that is responsible for degraded performance of network applications. In this paper, the Linux system's packet receive process is studied from NIC to application. We develop a mathematical model to characterize the Linux packet receiving process. Key factors that affect Linux systems network performance are analyzed.

  19. Analysis of Cultural Heritage by Accelerator Techniques and Analytical Imaging (United States)

    Ide-Ektessabi, Ari; Toque, Jay Arre; Murayama, Yusuke


    In this paper we present the result of experimental investigation using two very important accelerator techniques: (1) synchrotron radiation XRF and XAFS; and (2) accelerator mass spectrometry and multispectral analytical imaging for the investigation of cultural heritage. We also want to introduce a complementary approach to the investigation of artworks which is noninvasive and nondestructive that can be applied in situ. Four major projects will be discussed to illustrate the potential applications of these accelerator and analytical imaging techniques: (1) investigation of Mongolian Textile (Genghis Khan and Kublai Khan Period) using XRF, AMS and electron microscopy; (2) XRF studies of pigments collected from Korean Buddhist paintings; (3) creating a database of elemental composition and spectral reflectance of more than 1000 Japanese pigments which have been used for traditional Japanese paintings; and (4) visible light-near infrared spectroscopy and multispectral imaging of degraded malachite and azurite. The XRF measurements of the Japanese and Korean pigments could be used to complement the results of pigment identification by analytical imaging through spectral reflectance reconstruction. On the other hand, analysis of the Mongolian textiles revealed that they were produced between 12th and 13th century. Elemental analysis of the samples showed that they contained traces of gold, copper, iron and titanium. Based on the age and trace elements in the samples, it was concluded that the textiles were produced during the height of power of the Mongol empire, which makes them a valuable cultural heritage. Finally, the analysis of the degraded and discolored malachite and azurite demonstrates how multispectral analytical imaging could be used to complement the results of high energy-based techniques.

  20. Statistical modeling and analysis of the influence of antenna polarization error on received power

    Institute of Scientific and Technical Information of China (English)


    The problem of statistical modeling of antenna polarization error is studied and the statistical characteristics of antenna's received power are analyzed. A novel Stokes-vector-based method is presented to describe the conception of antenna's polarization purity. Statistical model of antenna's polarization error in polarization domain is then built up. When an antenna with polarization error of uniform distribution is illuminated by an arbitrary polarized incident field, the probability density of antenna's received power is derived analytically. Finally, a group of curves of deviation and standard deviation of received power are plotted numerically.

  1. Central Andean crustal structure from receiver function analysis (United States)

    Ryan, Jamie; Beck, Susan; Zandt, George; Wagner, Lara; Minaya, Estela; Tavera, Hernado


    The Central Andean Plateau (15°-27°S) is a high plateau in excess of 3 km elevation, associated with thickened crust along the western edge of the South America plate, in the convergent margin between the subducting Nazca plate and the Brazilian craton. We have calculated receiver functions using seismic data from a recent portable deployment of broadband seismometers in the Bolivian orocline (12°-21°S) region and combined them with waveforms from 38 other stations in the region to investigate crustal thickness and crust and mantle structures. Results from the receiver functions provide a more detailed map of crustal thickness than previously existed, and highlight mid-crustal features that match well with prior studies. The active volcanic arc and Altiplano have thick crust with Moho depths increasing from the central Altiplano (65 km) to the northern Altiplano (75 km). The Eastern Cordillera shows large along strike variations in crustal thickness. Along a densely sampled SW-NE profile through the Bolivian orocline there is a small region of thin crust beneath the high peaks of the Cordillera Real where the average elevations are near 4 km, and the Moho depth varies from 55 to 60 km, implying the crust is undercompensated by 5 km. In comparison, a broader region of high elevations in the Eastern Cordillera to the southeast near 20°S has a deeper Moho at 65-70 km and appears close to isostatic equilibrium at the Moho. Assuming the modern-day pattern of high precipitation on the flanks of the Andean plateau has existed since the late Miocene, we suggest that climate induced exhumation can explain some of the variations in present day crustal structure across the Bolivian orocline. We also suggest that south of the orocline at 20°S, the thicker and isostatically compensated crust is due to the absence of erosional exhumation and the occurrence of lithospheric delamination.

  2. Big Data Visual Analytics for Exploratory Earth System Simulation Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Steed, Chad A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Ricciuto, Daniel M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Shipman, Galen M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Smith, Brian E. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Thornton, Peter E. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Wang, Dali [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Shi, Xiaoying [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Williams, Dean N. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)


    Rapid increases in high performance computing are feeding the development of larger and more complex data sets in climate research, which sets the stage for so-called big data analysis challenges. However, conventional climate analysis techniques are inadequate in dealing with the complexities of today s data. In this paper, we describe and demonstrate a visual analytics system, called the Exploratory Data analysis ENvironment (EDEN), with specific application to the analysis of complex earth system simulation data sets. EDEN represents the type of interactive visual analysis tools that are necessary to transform data into insight, thereby improving critical comprehension of earth system processes. In addition to providing an overview of EDEN, we describe real-world studies using both point ensembles and global Community Land Model Version 4 (CLM4) simulations.

  3. An analytic method for sensitivity analysis of complex systems (United States)

    Zhu, Yueying; Wang, Qiuping Alexandre; Li, Wei; Cai, Xu


    Sensitivity analysis is concerned with understanding how the model output depends on uncertainties (variances) in inputs and identifying which inputs are important in contributing to the prediction imprecision. Uncertainty determination in output is the most crucial step in sensitivity analysis. In the present paper, an analytic expression, which can exactly evaluate the uncertainty in output as a function of the output's derivatives and inputs' central moments, is firstly deduced for general multivariate models with given relationship between output and inputs in terms of Taylor series expansion. A γ-order relative uncertainty for output, denoted by Rvγ, is introduced to quantify the contributions of input uncertainty of different orders. On this basis, it is shown that the widely used approximation considering the first order contribution from the variance of input variable can satisfactorily express the output uncertainty only when the input variance is very small or the input-output function is almost linear. Two applications of the analytic formula are performed to the power grid and economic systems where the sensitivities of both actual power output and Economic Order Quantity models are analyzed. The importance of each input variable in response to the model output is quantified by the analytic formula.

  4. Risk analysis by FMEA as an element of analytical validation. (United States)

    van Leeuwen, J F; Nauta, M J; de Kaste, D; Odekerken-Rombouts, Y M C F; Oldenhof, M T; Vredenbregt, M J; Barends, D M


    We subjected a Near-Infrared (NIR) analytical procedure used for screening drugs on authenticity to a Failure Mode and Effects Analysis (FMEA), including technical risks as well as risks related to human failure. An FMEA team broke down the NIR analytical method into process steps and identified possible failure modes for each step. Each failure mode was ranked on estimated frequency of occurrence (O), probability that the failure would remain undetected later in the process (D) and severity (S), each on a scale of 1-10. Human errors turned out to be the most common cause of failure modes. Failure risks were calculated by Risk Priority Numbers (RPNs)=O x D x S. Failure modes with the highest RPN scores were subjected to corrective actions and the FMEA was repeated, showing reductions in RPN scores and resulting in improvement indices up to 5.0. We recommend risk analysis as an addition to the usual analytical validation, as the FMEA enabled us to detect previously unidentified risks.

  5. An analytical method for ditching analysis of an airborne vehicle (United States)

    Ghaffari, Farhad


    A simple analytical method has been introduced for aerohydrodynamic load analysis of an airborne configuration during water ditching. The method employs an aerodynamic panel code, based on linear potential flow theory, to simulate the flow of air and water around an aircraft configuration. The free surface separating the air and water region is represented by doublet sheet singularities. Although all the theoretical load distributions are computed for air, provisions are made to correct the pressure coefficients obtained on the configuration wetted surfaces to account for the water density. As an analytical tool, the Vortex Separation Aerodynamic (VSAERO) code is chosen to carry out the present investigation. After assessing the validity of the method, its first application is to analyze the water ditching of the Space Shuttle configuration at a 12 degree attitude.


    Directory of Open Access Journals (Sweden)

    Ranjeet Mithari


    Full Text Available Leaf spring are of the oldest suspension component they are still frequently used. The current leaf spring is multiple leaf spring types with a steel material. It has high weight, low natural frequency, high corrosion, more noise. Therefore current multiple leaf spring is replaced by mono composite (E- Glass epoxy leaf spring which has high natural frequency, low weight etc. The maximum stress produced at the cylindrically joint than fixed joint. Therefore stress analysis of composite material mono leaf spring is carried out. The result of finite element method is verified with analytical calculation. Also compare the natural frequency by FFT analyzer with FEA.

  7. Facilitating the analysis of immunological data with visual analytic techniques. (United States)

    Shih, David C; Ho, Kevin C; Melnick, Kyle M; Rensink, Ronald A; Kollmann, Tobias R; Fortuno, Edgardo S


    Visual analytics (VA) has emerged as a new way to analyze large dataset through interactive visual display. We demonstrated the utility and the flexibility of a VA approach in the analysis of biological datasets. Examples of these datasets in immunology include flow cytometry, Luminex data, and genotyping (e.g., single nucleotide polymorphism) data. Contrary to the traditional information visualization approach, VA restores the analysis power in the hands of analyst by allowing the analyst to engage in real-time data exploration process. We selected the VA software called Tableau after evaluating several VA tools. Two types of analysis tasks analysis within and between datasets were demonstrated in the video presentation using an approach called paired analysis. Paired analysis, as defined in VA, is an analysis approach in which a VA tool expert works side-by-side with a domain expert during the analysis. The domain expert is the one who understands the significance of the data, and asks the questions that the collected data might address. The tool expert then creates visualizations to help find patterns in the data that might answer these questions. The short lag-time between the hypothesis generation and the rapid visual display of the data is the main advantage of a VA approach.

  8. Gravity field error analysis: Applications of GPS receivers and gradiometers on low orbiting platforms (United States)

    Schrama, E.


    The concept of a Global Positioning System (GPS) receiver as a tracking facility and a gradiometer as a separate instrument on a low orbiting platform offers a unique tool to map the Earth's gravitational field with unprecedented accuracies. The former technique allows determination of the spacecraft's ephemeris at any epoch to within 3 to 10 cm, the latter permits the measurement of the tensor of second order derivatives of the gravity field to within 0.01 to 0.0001 Eotvos units depending on the type of gradiometer. First, a variety of error sources in gradiometry where emphasis is placed on the rotational problem pursuing as well a static as a dynamic approach is described. Next, an analytical technique is described and applied for an error analysis of gravity field parameters from gradiometer and GPS observation types. Results are discussed for various configurations proposed on Topex/Poseidon, Gravity Probe-B, and Aristoteles, indicating that GPS only solutions may be computed up to degree and order 35, 55, and 85 respectively, whereas a combined GPS/gradiometer experiment on Aristoteles may result in an acceptable solution up to degree and order 240.

  9. Gravity field error analysis - Applications of Global Positioning System receivers and gradiometers on low orbiting platforms (United States)

    Schrama, Ernst J. O.


    The concept of a Global Positioning System (GPS) receiver as a tracking facility and a gradiometer as a separate instrument on a low-orbiting platform offers a unique tool to map the earth's gravitational field with unprecedented accuracies. The former technique allows determination of the spacecraft's ephemeris at any epoch to within 3-10 cm, the latter permits the measurement of the tensor of second order derivatives of the gravity field to within 0.01 to 0.0001 Eotvos units depending on the type of gradiometer. First, a variety of error sources in gradiometry where emphasis is placed on the rotational problem pursuing as well a static as a dynamic approach is described. Next, an analytical technique is described and applied for an error analysis of gravity field parameters from gradiometer and GPS observation types. Results are discussed for various configurations proposed on Topex/Poseidon, Gravity Probe-B, and Aristoteles, indicating that GPS only solutions may be computed up to degree and order 35, 55, and 85, respectively, whereas a combined GPS/gradiometer experiment on Aristoteles may result in an acceptable solution up to degree and order 240.

  10. Visual Analytics for Integrated Data Analysis in Space Science (United States)

    Rosa, Reinaldo; Sawant, Hanumant; Sych, Robert; Fernandes, Francisco

    Analysis of information from multiple data sources obtained through high resolution instrumental measurements has become a fundamental task in all scientific areas. The development of expert methods able to treat such multi- source data systems, with both large variability and measurement extension, is a key for studying complex scientific phenomena, especially those related to systemic analysis in space and environmental sciences. In this talk, we present a time series generalization introducing the concept of generalized numerical lattice, which represents a discrete sequence of temporal measures for a given variable. In this novel representation approach each generalized numerical lattice brings post-analytical data information. We define a generalized numerical lattice £ as a set of three parameters representing the following data properties: dimensionality, size and post-analytical measure. From this generalization, any multi-source database can be reduced to a closed set of classified time series in spatio-temporal generalized dimensions. As a case study, we show a preliminary application in space science data, highlighting the possibility of a real time analysis expert system. In this particular application, we have selected and analyzed, applying detrended fluctuation analysis (DFA), decimetric solar bursts associated to X flare-classes. The association with geomagnetic activity is also reported. DFA method is performed in the framework of a radio burst automatic monitoring system. Our results may characterize the variability pattern evolution, computing the DFA scaling exponent, scanning the time series by a short windowing before the extreme event. For the first time, the application of systematic fluctuation analysis for space weather purposes is presented.

  11. Structural Analysis of Composite Laminates using Analytical and Numerical Techniques

    Directory of Open Access Journals (Sweden)

    Sanghi Divya


    Full Text Available A laminated composite material consists of different layers of matrix and fibres. Its properties can vary a lot with each layer’s or ply’s orientation, material property and the number of layers itself. The present paper focuses on a novel approach of incorporating an analytical method to arrive at a preliminary ply layup order of a composite laminate, which acts as a feeder data for the further detailed analysis done on FEA tools. The equations used in our MATLAB are based on analytical study code and supply results that are remarkably close to the final optimized layup found through extensive FEA analysis with a high probabilistic degree. This reduces significant computing time and saves considerable FEA processing to obtain efficient results quickly. The result output by our method also provides the user with the conditions that predicts the successive failure sequence of the composite plies, a result option which is not even available in popular FEM tools. The predicted results are further verified by testing the laminates in the laboratory and the results are found in good agreement.

  12. An analytic method for sensitivity analysis of complex systems

    CERN Document Server

    Zhu, Yueying; Li, Wei; Cai, Xu


    Sensitivity analysis is concerned with understanding how the model output depends on uncertainties (variances) in inputs and then identifies which inputs are important in contributing to the prediction imprecision. Uncertainty determination in output is the most crucial step in sensitivity analysis. In the present paper, an analytic expression, which can exactly evaluate the uncertainty in output as a function of the output's derivatives and inputs' central moments, is firstly deduced for general multivariate models with given relationship between output and inputs in terms of Taylor series expansion. A $\\gamma$-order relative uncertainty for output, denoted by $\\mathrm{R^{\\gamma}_v}$, is introduced to quantify the contributions of input uncertainty of different orders. On this basis, it is shown that the widely used approximation considering the first order contribution from the variance of input variable can satisfactorily express the output uncertainty only when the input variance is very small or the inpu...

  13. A Visual Analytics Approach for Correlation, Classification, and Regression Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Steed, Chad A [ORNL; SwanII, J. Edward [Mississippi State University (MSU); Fitzpatrick, Patrick J. [Mississippi State University (MSU); Jankun-Kelly, T.J. [Mississippi State University (MSU)


    New approaches that combine the strengths of humans and machines are necessary to equip analysts with the proper tools for exploring today's increasing complex, multivariate data sets. In this paper, a novel visual data mining framework, called the Multidimensional Data eXplorer (MDX), is described that addresses the challenges of today's data by combining automated statistical analytics with a highly interactive parallel coordinates based canvas. In addition to several intuitive interaction capabilities, this framework offers a rich set of graphical statistical indicators, interactive regression analysis, visual correlation mining, automated axis arrangements and filtering, and data classification techniques. The current work provides a detailed description of the system as well as a discussion of key design aspects and critical feedback from domain experts.

  14. Design and analysis of a novel concentrated photovoltaic-thermal receiver concept (United States)

    Hangweirer, Manfred; Höller, Robert; Schneider, Hartmut


    Solar concentrators, which focus the sunlight on a small surface of solar cells, are a promising way of reducing expensive semiconductor area and thus also the energy generation costs of photovoltaics. This paper presents the design and the analysis of a concentrated photovoltaic (CPV) receiver for a linear Fresnel concentrator mirror module. The receiver is designed as hybrid concentrated photovoltaic-thermal (CPV-T) receiver, which enables simultaneous generation of power and heat in one compact receiver. Spectral splitting with selective absorptive media and thermal decoupling of heat carrier and solar cells improves the electrical efficiency. Computational fluid dynamics (CFD) simulations of various receiver-setups result in an electrical efficiency of the receiver up to 6.2% and a thermal efficiency of up to 61.2% at a specific selected operating design point. 62% of the wavelengths of the incoming solar spectrum between 500 to 1100 nm hit the solar cells.

  15. An analytical paradigm for the analysis of national inmigration patterns. (United States)

    Weisberg, Y; Eaglstein, A S


    This study proposes and demonstrates an analytic paradigm based upon a substantive categorization of a set of inmigration correlates. It exemplifies the notion of categorizing, analyzing according to the categorization, and subsequently discussing the phenomenon in more depth. The paradigm has 2 steps: 1) the variables are categorized according to the cells resulting from the intersection of a preferably small number of nominal dimensions and 2) the data are analyzed, directly anchored in the prior categorization. The data used is Israel's 1983 census macro-data gathered from the Central Bureau of Statistics for the Israeli towns with populations of at least 5000. The authors defined 6 variables as push variables and 4 as pull variables. Results of the regression employing push variables show that 4 variables accounting for 72% of inmigration were found to significantly predict inmigration: 1) unemployment, 2) percentage of Asians-Africans, 3) town size, and 4) religiosity. Within the pull classification, the regression analysis reveals that 2 of the 4 variables explain 31% of the inmigration variance: 1) educational level (26%) and 2) income (5%). The 1st regression analysis on the 2nd dimension shows that the percentage of Asian-African origin and town population size account for 32% of the immigration variance. In the 2nd regression analysis, unemployment explains 48% of the inmigration variance and educational level explains 8%. In the 3rd regression, only home crowding explains a significant amount of the immigration variance (19%). Results of a multiple regression analysis show that unemployment level, percentage of Asian-Africans, population size, and level of religiosity account for 72% of the inmigration variance. Thus, the characteristics of a town inmigrating (push variables) are demographic, economic, and social. However, the attractive features of a town are only economic. Among all economic factors, unemployment is primary. In addition, not only are

  16. Dairy Analytics and Nutrient Analysis (DANA) Prototype System User Manual

    Energy Technology Data Exchange (ETDEWEB)

    Sam Alessi; Dennis Keiser


    This document is a user manual for the Dairy Analytics and Nutrient Analysis (DANA) model. DANA provides an analysis of dairy anaerobic digestion technology and allows users to calculate biogas production, co-product valuation, capital costs, expenses, revenue and financial metrics, for user customizable scenarios, dairy and digester types. The model provides results for three anaerobic digester types; Covered Lagoons, Modified Plug Flow, and Complete Mix, and three main energy production technologies; electricity generation, renewable natural gas generation, and compressed natural gas generation. Additional options include different dairy types, bedding types, backend treatment type as well as numerous production, and economic parameters. DANA’s goal is to extend the National Market Value of Anaerobic Digester Products analysis (informa economics, 2012; Innovation Center, 2011) to include a greater and more flexible set of regional digester scenarios and to provide a modular framework for creation of a tool to support farmer and investor needs. Users can set up scenarios from combinations of existing parameters or add new parameters, run the model and view a variety of reports, charts and tables that are automatically produced and delivered over the web interface. DANA is based in the INL’s analysis architecture entitled Generalized Environment for Modeling Systems (GEMS) , which offers extensive collaboration, analysis, and integration opportunities and greatly speeds the ability construct highly scalable web delivered user-oriented decision tools. DANA’s approach uses server-based data processing and web-based user interfaces, rather a client-based spreadsheet approach. This offers a number of benefits over the client-based approach. Server processing and storage can scale up to handle a very large number of scenarios, so that analysis of county, even field level, across the whole U.S., can be performed. Server based databases allow dairy and digester

  17. Compound-specific radiocarbon analysis - Analytical challenges and applications

    Energy Technology Data Exchange (ETDEWEB)

    Mollenhauer, G; Rethemeyer, J [Alfred-Wegener Institute for Polar and Marine Research Am Handelshafen 12, 27570 Bremerhaven (Germany)], E-mail:


    Within the last decades, techniques have become available that allow measurement of isotopic compositions of individual organic compounds (compound-specific isotope measurements). Most often the carbon isotopic composition of these compounds is studied, including stable carbon ({delta}{sup 13}C) and radiocarbon ({delta}{sup 14}C) measurements. While compound-specific stable carbon isotope measurements are fairly simple, and well-established techniques are widely available, radiocarbon analysis of specific organic compounds is a more challenging method. Analytical challenges include difficulty obtaining adequate quantities of sample, tedious and complicated laboratory separations, the lack of authentic standards for measuring realistic processing blanks, and large uncertainties in values of {delta}{sup 14}C at small sample sizes. The challenges associated with sample preparation for compound-specific {delta}{sup 14}C measurements will be discussed in this contribution. Several years of compound-specific radiocarbon analysis have revealed that in most natural samples, purified organic compounds consist of heterogeneous mixtures of the same compound. These mixtures could derive from multiple sources, each having a different initial reservoir age but mixed in the same terminal reservoir, from a single source but mixed after deposition, or from a prokaryotic organism using variable carbon sources including mobilization of ancient carbon. These processes not only represent challenges to the interpretation of compound-specific radiocarbon data, but provide unique tools for the understanding of biogeochemical and sedimentological processes influencing the preserved organic geochemical records in marine sediments. We will discuss some examples where compound-specific radiocarbon analysis has provided new insights for the understanding of carbon source utilization and carbon cycling.

  18. Analytic central path, sensitivity analysis and parametric linear programming

    NARCIS (Netherlands)

    A.G. Holder; J.F. Sturm; S. Zhang (Shuzhong)


    textabstractIn this paper we consider properties of the central path and the analytic center of the optimal face in the context of parametric linear programming. We first show that if the right-hand side vector of a standard linear program is perturbed, then the analytic center of the optimal face

  19. CFD analysis of supercritical CO2 used as HTF in a solar tower receiver (United States)

    Roldán, M. I.; Fernández-Reche, J.


    The relative cost of a solar receiver can be minimized by the selection of an appropriate heat transfer fluid capable of achieving high receiver efficiencies. In a conventional central receiver system, the concentrated solar energy is transferred from the receiver tube walls to the heat transfer fluid (HTF), which passes through a heat exchanger to generate steam for a Rankine cycle. Thus, higher working fluid temperature is associated with greater efficiency in receiver and power cycle. Emerging receiver designs that can enable higher efficiencies using advanced power cycles, such as supercritical CO2 (s-CO2) closed-loop Brayton cycles, include direct heating of s-CO2 in tubular receiver designs capable of withstanding high internal fluid pressures (around 20 MPa) and temperatures (900 K). Due to the high pressures required and the presence of moving components installed in pipelines (ball-joints and/or flexible connections), the use of s-CO2 presents many technical challenges due to the compatibility of seal materials and fluid leakages of the moving connections. These problems are solved in solar tower systems because the receiver is fixed. In this regard, a preliminary analysis of a tubular receiver with s-CO2 as HTF has been developed using the design of a molten-salt receiver which was previously tested at Plataforma Solar de Almería (PSA). Therefore, a simplified CFD model has been carried out in this study in order to analyze the feasibility of s-CO2 as HTF in solar towers. Simulation results showed that the heat gained by s-CO2 was around 75% greater than the one captured by molten salts (fluid inlet temperature of 715 K), but at a pressure range of 7.5-9.7 MPa. Thus, the use of s-CO2 as HTF in solar tower receivers appears to be a promising alternative, taking into account both the operating conditions required and their maintenance cost.

  20. BER Performance Analysis of Rake Receiver in Rayleigh Fading Channel for UMTS environment

    Directory of Open Access Journals (Sweden)

    Pravindra Kumar


    Full Text Available The goal for the third generation of mobile communications system is to integrate a wide variety of communication services such as high speed data, video and multimedia traffic as well as voice signals. Under the Universal Mobile Telecommunication System (UMTS environment the Third Generation (3G has many advantages such as highly efficient spectrum utilisation and variable user data rates. In this paper, we present the bit error rate (BER performance analysis of Rake Receiver under UMTS environment with BPSK modulation technique and the convolutional coding at the transmitter and viterbi decoding at the receiver side. The Standard Gaussian Approximation (SGA is used to evaluate the performance of Rake Receiver over a frequency selective Rayleigh fading channel. The data is modulated, encoded, spread and transmitted through a frequency selective Rayleigh fading channel. The transmitted signal is corrupted by multiple access interference, and is further corrupted by AWGNat the receiver. In the receiver, dispreading, decoded and demodulated. Rake Receiver, directive antenna are employed to improve the system performance. We examined the BER performance of Rake Receiver with, varying the number of users, spreading factor, Rake fingers, Interfering Cells, and the value of directivity of antenna at base Station. From the results we have seen that the BER performance of Rake Receiver is affected by varying these parameters and gives useful results.


    Institute of Scientific and Technical Information of China (English)



    The influence of the selection of receiving slits and the use of standard samples with random orientation on the result of quantitative texture analysis was tested and discussed. The result proves that it will improve the precision of the analysis to use proper slits and a randomly oriented standard sample. A simple method was given to interpolate the correction curves of random intensities.

  2. Analytic central path, sensitivity analysis and parametric linear programming


    A.G. Holder; Sturm, J.F.; Zhang, Shuzhong


    textabstractIn this paper we consider properties of the central path and the analytic center of the optimal face in the context of parametric linear programming. We first show that if the right-hand side vector of a standard linear program is perturbed, then the analytic center of the optimal face is one-side differentiable with respect to the perturbation parameter. In that case we also show that the whole analytic central path shifts in a uniform fashion. When the objective vector is pertur...

  3. Analysis of optical amplifier noise in coherent optical communication systems with optical image rejection receivers

    DEFF Research Database (Denmark)

    Jørgensen, Bo Foged; Mikkelsen, Benny; Mahon, Cathal J.


    performance. Two types of optical image rejection receivers are investigated: a novel, all-optical configuration and the conventional, microwave-based configuration. The analysis shows that local oscillator-spontaneous emission beat noise (LO-SP), signal-spontaneous emission beat noise (S-SP), and spontaneous......A detailed theoretical analysis of optical amplifier noise in coherent optical communication systems with heterodyne receivers is presented. The analysis quantifies in particular how optical image rejection receiver configurations reduce the influence of optical amplifier noise on system......-spontaneous beat noise (SP-SP) can all be reduced by 3 dB, thereby doubling the dynamic range of the optical amplifier. A 2.5-dB improvement in dynamic range has been demonstrated experimentally with the all-optical image rejection configuration. The implications of the increased dynamic range thus obtained...

  4. Nonlinear Scaling Laws for Parametric Receiving Arrays. Part II. Numerical Analysis (United States)


    8217" " .’Ml’.1 ’.■■’: ■ ’ ^ t- Nonlinear Scaling Laws for Parametric Receiving Arrays Part II Numerical Analysis » - m • o prepared ...8217 ’ ■ — Nonlinear Scaling Laws for Parametric Receiving Arrays » z Part II. Numerical Analysis prepared under: A ——^ N0ÖJ339- 7 5 - C -J02 59, //V-ARPA Order...IF ’IP ,6T, 10 .HNO. IR .I_E. £0> riELTI = LiELTrJ IF ’IP .GT. 3 0 .HMD. IP .LE. 3 0;. [ IELT I = IiELT3 IF

  5. Thermodynamic Analysis of Beam down Solar Gas Turbine Power Plant equipped with Concentrating Receiver System (United States)

    Azharuddin; Santarelli, Massimo


    Thermodynamic analysis of a closed cycle, solar powered Brayton gas turbine power plant with Concentrating Receiver system has been studied. A Brayton cycle is simpler than a Rankine cycle and has an advantage where the water is scarce. With the normal Brayton cycle a Concentrating Receiver System has been analysed which has a dependence on field density and optical system. This study presents a method of optimization of design parameter, such as the receiver working temperature and the heliostats density. This method aims at maximizing the overall efficiency of the three major subsystem that constitute the entire plant, namely, the heliostat field and the tower, the receiver and the power block. The results of the optimization process are shown and analysed.

  6. Analytical Model for High Impedance Fault Analysis in Transmission Lines

    Directory of Open Access Journals (Sweden)

    S. Maximov


    Full Text Available A high impedance fault (HIF normally occurs when an overhead power line physically breaks and falls to the ground. Such faults are difficult to detect because they often draw small currents which cannot be detected by conventional overcurrent protection. Furthermore, an electric arc accompanies HIFs, resulting in fire hazard, damage to electrical devices, and risk with human life. This paper presents an analytical model to analyze the interaction between the electric arc associated to HIFs and a transmission line. A joint analytical solution to the wave equation for a transmission line and a nonlinear equation for the arc model is presented. The analytical model is validated by means of comparisons between measured and calculated results. Several cases of study are presented which support the foundation and accuracy of the proposed model.

  7. A fossil subduction zone in the East Greenland Caledonides revealed by a Receiver Function analysis

    DEFF Research Database (Denmark)

    Schiffer, Christian; Jacobsen, B. H.; Balling, N.;

    evidence for the processes before and under the Caledonian orogeny. We performed a Receiver Function analysis of data from 11 seismological broadband stations forming the Ella-Øarray. This array, maintained by Aarhus University, covered an approximately 270 km long profile, spanning the East Greenland...

  8. Identifying failure mechanisms in LDMOS transistors by analytical stability analysis

    NARCIS (Netherlands)

    Ferrara, A.; Steeneken, P.G.; Boksteen, B.K.; Heringa, A.; Scholten, A.J.; Schmitz, J.; Hueting, R.J.E.


    In this work, analytical stability equations are derived and combined with a physics-based model of an LDMOS transistor in order to identify the primary cause of failure in different operating and bias conditions. It is found that there is a gradual boundary between an electrical failure region at h

  9. Power and Efficiency Analysis of a Solar Central Receiver Combined Cycle Plant with a Small Particle Heat Exchanger Receiver (United States)

    Virgen, Matthew Miguel

    Two significant goals in solar plant operation are lower cost and higher efficiencies. To achieve those goals, a combined cycle gas turbine (CCGT) system, which uses the hot gas turbine exhaust to produce superheated steam for a bottoming Rankine cycle by way of a heat recovery steam generator (HRSG), is investigated in this work. Building off of a previous gas turbine model created at the Combustion and Solar Energy Laboratory at SDSU, here are added the HRSG and steam turbine model, which had to handle significant change in the mass flow and temperature of air exiting the gas turbine due to varying solar input. A wide range of cases were run to explore options for maximizing both power and efficiency from the proposed CSP CCGT plant. Variable guide vanes (VGVs) were found in the earlier model to be an effective tool in providing operational flexibility to address the variable nature of solar input. Combined cycle efficiencies in the range of 50% were found to result from this plant configuration. However, a combustor inlet temperature (CIT) limit leads to two distinct Modes of operation, with a sharp drop in both plant efficiency and power occurring when the air flow through the receiver exceeded the CIT limit. This drawback can be partially addressed through strategic use of the VGVs. Since system response is fully established for the relevant range of solar input and variable guide vane angles, the System Advisor Model (SAM) from NREL can be used to find what the actual expected solar input would be over the course of the day, and plan accordingly. While the SAM software is not yet equipped to model a Brayton cycle cavity receiver, appropriate approximations were made in order to produce a suitable heliostat field to fit this system. Since the SPHER uses carbon nano-particles as the solar absorbers, questions of particle longevity and how the particles might affect the flame behavior in the combustor were addressed using the chemical kinetics software Chemkin

  10. An Analysis of the Effects of RFID Tags on Narrowband Navigation and Communication Receivers (United States)

    LaBerge, E. F. Charles


    The simulated effects of the Radio Frequency Identification (RFID) tag emissions on ILS Localizer and ILS Glide Slope functions match the analytical models developed in support of DO-294B provided that the measured peak power levels are adjusted for 1) peak-to-average power ratio, 2) effective duty cycle, and 3) spectrum analyzer measurement bandwidth. When these adjustments are made, simulated and theoretical results are in extraordinarily good agreement. The relationships hold over a large range of potential interference-to-desired signal power ratios, provided that the adjusted interference power is significantly higher than the sum of the receiver noise floor and the noise-like contributions of all other interference sources. When the duty-factor adjusted power spectral densities are applied in the evaluation process described in Section 6 of DO-294B, most narrowband guidance and communications radios performance parameters are unaffected by moderate levels of RFID interference. Specific conclusions and recommendations are provided.

  11. Analytical Analysis of Vehicle Routing and Inventory Routing Problems (United States)


    The objective of the project is to perform analytical analyses of heuristics for the Vehicle Routing Problem ( VRP ) and apply the results in models...asymptotic optimal solution value of the VRP with capacity and time window constraints and used it to develop a new and efficient algorithm. (2) Obtained a...characterization of the effectiveness of set partitioning formulations for VRPs . (3) Characterized the worst case behavior of the linear programming

  12. Analytical Analysis and Numerical Solution of Two Flavours Skyrmion

    CERN Document Server

    Hadi, Miftachul; Hermawanto, Denny


    Two flavours Skyrmion will be analyzed analytically, in case of static and rotational Skyrme equations. Numerical solution of a nonlinear scalar field equation, i.e. the Skyrme equation, will be worked with finite difference method. This article is a more comprehensive version of \\textit{SU(2) Skyrme Model for Hadron} which have been published at Journal of Theoretical and Computational Studies, Volume \\textbf{3} (2004) 0407.

  13. Marketing Mix Formulation for Higher Education: An Integrated Analysis Employing Analytic Hierarchy Process, Cluster Analysis and Correspondence Analysis (United States)

    Ho, Hsuan-Fu; Hung, Chia-Chi


    Purpose: The purpose of this paper is to examine how a graduate institute at National Chiayi University (NCYU), by using a model that integrates analytic hierarchy process, cluster analysis and correspondence analysis, can develop effective marketing strategies. Design/methodology/approach: This is primarily a quantitative study aimed at…

  14. An Analytic Hierarchy Process Analysis: Application to Subscriber Retention Decisions in the Nigerian Mobile Telecommunications

    Directory of Open Access Journals (Sweden)

    Adebiyi Sulaimon Olanrewaju


    Full Text Available The introduction of mobile number portability (MNP in the Nigerian telecommunications industry has brought a new challenge for mobile operators. This study investigates the use of Analytic Hierarchy Process (AHP in customer retention decisions in the Nigerian telecommunication industry using a cross-sectional survey design. Primary data were obtained through questionnaires administered to 480 mobile telecommunications subscribers in six tertiary institutions located in Lagos State, Nigeria. These educational institutions were chosen using a multistage sampling technique. Of 438 questionnaires received from subscribers, 408 were valid. Based on this sample data an AHP model was built to assess the determinants of customer retention decisions. Next, eigen values, an eigen vector and maximum lambda (λMax were obtained using the AHP analysis for the matrices. This analysis shows that customers considered call quality as the important in the retention decision. We conclude that AHP is a meaningful tool for determining what motivates retention decisions, that can help network operators formulate effective customer retention strategies.

  15. Two-port network analysis and modeling of a balanced armature receiver. (United States)

    Kim, Noori; Allen, Jont B


    Models for acoustic transducers, such as loudspeakers, mastoid bone-drivers, hearing-aid receivers, etc., are critical elements in many acoustic applications. Acoustic transducers employ two-port models to convert between acoustic and electromagnetic signals. This study analyzes a widely-used commercial hearing-aid receiver ED series, manufactured by Knowles Electronics, Inc. Electromagnetic transducer modeling must consider two key elements: a semi-inductor and a gyrator. The semi-inductor accounts for electromagnetic eddy-currents, the 'skin effect' of a conductor (Vanderkooy, 1989), while the gyrator (McMillan, 1946; Tellegen, 1948) accounts for the anti-reciprocity characteristic [Lenz's law (Hunt, 1954, p. 113)]. Aside from Hunt (1954), no publications we know of have included the gyrator element in their electromagnetic transducer models. The most prevalent method of transducer modeling evokes the mobility method, an ideal transformer instead of a gyrator followed by the dual of the mechanical circuit (Beranek, 1954). The mobility approach greatly complicates the analysis. The present study proposes a novel, simplified and rigorous receiver model. Hunt's two-port parameters, the electrical impedance Ze(s), acoustic impedance Za(s) and electro-acoustic transduction coefficient Ta(s), are calculated using ABCD and impedance matrix methods (Van Valkenburg, 1964). The results from electrical input impedance measurements Zin(s), which vary with given acoustical loads, are used in the calculation (Weece and Allen, 2010). The hearing-aid receiver transducer model is designed based on energy transformation flow [electric→ mechanic→ acoustic]. The model has been verified with electrical input impedance, diaphragm velocity in vacuo, and output pressure measurements. This receiver model is suitable for designing most electromagnetic transducers and it can ultimately improve the design of hearing-aid devices by providing a simplified yet accurate, physically

  16. SplitRFLab: A MATLAB GUI toolbox for receiver function analysis based on SplitLab (United States)

    Xu, Mijian; Huang, Hui; Huang, Zhouchuan; Wang, Liangshu


    We add new modules for receiver function (RF) analysis in SplitLab toolbox, which includes the manual RF analysis module, automatic RF analysis and related quality control modules, and H- k stacking module. The updated toolbox (named SplitRFLab toolbox), especially its automatic RF analysis module, could calculate the RFs quickly and efficiently, which is very useful in RF analysis with huge amount of seismic data. China is now conducting the ChinArray project that plans to deploy thousands of portable stations across Chinese mainland. Our SplitRFLab toolbox may obtain reliable RF results quickly at the first time, which provide essentially new constraint to the crustal and mantle structures.

  17. Analysis and analytical characterization of bioheat transfer during radiofrequency ablation. (United States)

    Wang, Keyong; Tavakkoli, Fatemeh; Wang, Shujuan; Vafai, Kambiz


    Understanding thermal transport and temperature distribution within biological organs is important for therapeutic aspects related to hyperthermia treatments such as radiofrequency ablation (RFA). Unlike surface heating, the RFA treatment volumetrically heats up the biological media using a heating probe which provides the input energy. In this situation, the shape of the affected region is annular, which is described by an axisymmetric geometry. To better understand the temperature responses of the living tissues subject to RFA, comprehensive characteristics of bioheat transport through the annular biological medium is presented under local thermal non-equilibrium (LTNE) condition. Following the operational features of the RFA treatment, based on the porous media theory, analytical solutions have been derived for the blood and tissue temperature distributions as well as an overall heat exchange correlation in cylindrical coordinates. Our analytical results have been validated against three limiting cases which exist in the literature. The effects of various physiological parameters, such as metabolic heat generation, volume fraction of the vascular space, ratio of the effective blood to tissue conductivities, different biological media and the rate of heat exchange between the lumen and the tissue are investigated. Solutions developed in this study are valuable for thermal therapy planning of RFA. A criterion is also established to link deep heating protocol to surface heating.


    Analytical Chemistry voted to conduct a round robin to estimate the interlaboratory reproducibility. The round robin was designed to facilitate statistical analysis of the data. Three samples representing different purity levels as

  19. Archetypal facets: analysis of clinical case supporting the Analytical Psychology

    Directory of Open Access Journals (Sweden)

    Odéssia Fernanda Gomes de Assis


    Full Text Available This paper is a case study of a patient who came to us complaining of difficulties within the family due to the fact that he could not deny anything to people. The case was analyzed based on the framework of Analytical Psychology, founded mainly on Carl Gustav Jung. Psychological counseling sessions were held, and after the sessions, theoretical approaches have been made based on the material presented by the patient. The interventions were performed with the goal of enabling the patient and insights she sought other ways to position themselves in the world and to relate to the people around. Over the course of the sessions, the patient was able to construct a context in which allow and deny more in accordance with their abilities and possibilities.

  20. Analysis III analytic and differential functions, manifolds and Riemann surfaces

    CERN Document Server

    Godement, Roger


    Volume III sets out classical Cauchy theory. It is much more geared towards its innumerable applications than towards a more or less complete theory of analytic functions. Cauchy-type curvilinear integrals are then shown to generalize to any number of real variables (differential forms, Stokes-type formulas). The fundamentals of the theory of manifolds are then presented, mainly to provide the reader with a "canonical'' language and with some important theorems (change of variables in integration, differential equations). A final chapter shows how these theorems can be used to construct the compact Riemann surface of an algebraic function, a subject that is rarely addressed in the general literature though it only requires elementary techniques. Besides the Lebesgue integral, Volume IV will set out a piece of specialized mathematics towards which the entire content of the previous volumes will converge: Jacobi, Riemann, Dedekind series and infinite products, elliptic functions, classical theory of modular fun...

  1. Analytic robust stability analysis of SVD orbit feedback

    CERN Document Server

    Pfingstner, Jürgen


    Orbit feedback controllers are indispensable for the operation of modern particle accelerators. Many such controllers are based on the decoupling of the inputs and outputs of the system to be controlled with the help of the singular value decomposition (SVD controller). It is crucial to verify the stability of SVD controllers, also in the presence of mismatches between the used accelerator model and the real machine (robust stability problem). In this paper, analytical criteria for guaranteed stability margins of SVD orbit feedback systems for three different types of model mismatches are presented: scaling errors of actuators and BPMs (beam position monitors) and additive errors of the orbit response matrix. For the derivation of these criteria, techniques from robust control theory have been used, e.g the small gain theorem. The obtained criteria can be easily applied directly to other SVD orbit feedback systems. As an example, the criteria were applied to the orbit feedback system of the Compact Linear ...

  2. Analytical Model Analysis Of Distributed Cooperative Spectrum Sensing Method

    Directory of Open Access Journals (Sweden)

    Ravi Prakash Shukla


    Full Text Available Spectrum sensing is a key function of cognitive radio to prevent the harmful interference with licensed users and identify the available spectrum for improving the spectrum’s utilization. Various methods for spectrum sensing control, such as deciding which sensors should perform sensing simultaneously and finding the appropriate trade-off between probability of misdetection and false alarm rate, are described. However, detection performance in practice is often compromised with multipath fading, shadowing and receiver uncertainty issues. To mitigate the impact of these issues, cooperative spectrum sensing has been shown to be an effective method to improve the detection performance by exploiting spatial diversity.

  3. Waste Receiving and Processing (WRAP) Facility Final Safety Analysis Report (FSAR)

    Energy Technology Data Exchange (ETDEWEB)



    The Waste Receiving and Processing Facility (WRAP), 2336W Building, on the Hanford Site is designed to receive, confirm, repackage, certify, treat, store, and ship contact-handled transuranic and low-level radioactive waste from past and present U.S. Department of Energy activities. The WRAP facility is comprised of three buildings: 2336W, the main processing facility (also referred to generically as WRAP); 2740W, an administrative support building; and 2620W, a maintenance support building. The support buildings are subject to the normal hazards associated with industrial buildings (no radiological materials are handled) and are not part of this analysis except as they are impacted by operations in the processing building, 2336W. WRAP is designed to provide safer, more efficient methods of handling the waste than currently exist on the Hanford Site and contributes to the achievement of as low as reasonably achievable goals for Hanford Site waste management.

  4. The RIP and block-RIP analysis of Nyquist folding receiver for recovering signals (United States)

    Jiang, Kaili; Chen, Sujuan; Tang, Bin


    Modern radar and communication systems require the detection and parameter estimation of signal under a broadband radio frequency (RF) environment. The Nyquist folding receiver (NYFR) is an efficient analog-to-information (A2I) architecture. It can use the compressive sensing (CS) techniques to break the limitations of the analog-to-digital converter (ADC). This paper demonstrates the restricted isometry property (RIP) of the NYFR deterministically by applying the Gershgorin circle theory. And, the NYFR suffers a poor RIP for the broadband signal, which will lead the conventional CS algorithms to be invalid. So, we derive the Fourier spectrum of the broadband signal, which covered multiple Nyquist zones and received by the NYFR. Then, the broadband signal can be regarded as the block-sparse signal. And, the block CS algorithms are applied for recovering the signal based on the analysis of the block-RIP. Finally, the simulation experiments demonstrate the validity of the findings.

  5. Security analysis - from analytical methods to intelligent systems

    Energy Technology Data Exchange (ETDEWEB)

    Lambert-Torres, G.; Silva, A.P. Alves da; Ferreira, C. [Escola Federal de Engenharia de Itajuba, MG (Brazil); Mattos dos Reis, L.O. [Taubate Univ., SP (Brazil)


    This paper presents an alternative approach to Security Analysis based on Artificial Neural Network (ANN) techniques. This new technique tries to imitate the human brain and is based on neurons and synopses. A critical review of the ANN used in Power System Operation problem solving is made, while structures to solve the Security Analysis problems are proposed. (author) 7 refs., 4 figs.

  6. Comparative Analysis between Fuzzy and Traditional Analytical Hierarchy Process

    Directory of Open Access Journals (Sweden)

    Mulubrhan Freselam


    Full Text Available Analytic Hierarchy Process (AHP is one of the techniques commonly used for prioritizing different alternatives, by using complex criteria. In real applications, conventional AHP assumes the expert judgment as it is exact and use crisp number leading to inconsideration of the uncertainty that came from linguistic variable. Fuzzy logic deals with situations which are vague or unwell defined and gives a quantify value. In this study a comparison is made between traditional AHP and fuzzy AHP by taking a case of selecting an effective oil refinery. The selection is conducted using system effectiveness as a criterion. The two approaches have been compared on the same hierarchy structure and criteria set and the result show that in both case dual drum scheme (DDS has the highest priority but different value that is 0.51 and 0.36 for AHP and FAHP respectively which shows that if the expert opinion is certain AHP should be used if not FAHP should be preferred

  7. General analytical solutions for DC/AC circuit network analysis

    CERN Document Server

    Rubido, Nicolás; Baptista, Murilo S


    In this work, we present novel general analytical solutions for the currents that are developed in the edges of network-like circuits when some nodes of the network act as sources/sinks of DC or AC current. We assume that Ohm's law is valid at every edge and that charge at every node is conserved (with the exception of the source/sink nodes). The resistive, capacitive, and/or inductive properties of the lines in the circuit define a complex network structure with given impedances for each edge. Our solution for the currents at each edge is derived in terms of the eigenvalues and eigenvectors of the Laplacian matrix of the network defined from the impedances. This derivation also allows us to compute the equivalent impedance between any two nodes of the circuit and relate it to currents in a closed circuit which has a single voltage generator instead of many input/output source/sink nodes. Contrary to solving Kirchhoff's equations, our derivation allows to easily calculate the redistribution of currents that o...

  8. Sensitivity to imputation models and assumptions in receiver operating characteristic analysis with incomplete data. (United States)

    Karakaya, Jale; Karabulut, Erdem; Yucel, Recai M

    Modern statistical methods using incomplete data have been increasingly applied in a wide variety of substantive problems. Similarly, receiver operating characteristic (ROC) analysis, a method used in evaluating diagnostic tests or biomarkers in medical research, has also been increasingly popular problem in both its development and application. While missing-data methods have been applied in ROC analysis, the impact of model mis-specification and/or assumptions (e.g. missing at random) underlying the missing data has not been thoroughly studied. In this work, we study the performance of multiple imputation (MI) inference in ROC analysis. Particularly, we investigate parametric and non-parametric techniques for MI inference under common missingness mechanisms. Depending on the coherency of the imputation model with the underlying data generation mechanism, our results show that MI generally leads to well-calibrated inferences under ignorable missingness mechanisms.

  9. Analytical Laboratory (United States)

    Federal Laboratory Consortium — The Analytical Labspecializes in Oil and Hydraulic Fluid Analysis, Identification of Unknown Materials, Engineering Investigations, Qualification Testing (to support...

  10. Analysis of Multi-Antenna GNSS Receiver Performance under Jamming Attacks

    Directory of Open Access Journals (Sweden)

    Niranjana Vagle


    Full Text Available Although antenna array-based Global Navigation Satellite System (GNSS receivers can be used to mitigate both narrowband and wideband electronic interference sources, measurement distortions induced by array processing methods are not suitable for high precision applications. The measurement distortions have an adverse effect on the carrier phase ambiguity resolution, affecting the navigation solution. Depending on the array attitude information availability and calibration parameters, different spatial processing methods can be implemented although they distort carrier phase measurements in some cases. This paper provides a detailed investigation of the effect of different array processing techniques on array-based GNSS receiver measurements and navigation performance. The main novelty of the paper is to provide a thorough analysis of array-based GNSS receivers employing different beamforming techniques from tracking to navigation solution. Two beamforming techniques, namely Power Minimization (PM and Minimum Power Distortionless Response (MPDR, are being investigated. In the tracking domain, the carrier Doppler, Phase Lock Indicator (PLI, and Carrier-to-Noise Ratio (C/N0 are analyzed. Pseudorange and carrier phase measurement distortions and carrier phase position performance are also evaluated. Performance analyses results from simulated GNSS signals and field tests are provided.

  11. Analysis of Multi-Antenna GNSS Receiver Performance under Jamming Attacks. (United States)

    Vagle, Niranjana; Broumandan, Ali; Lachapelle, Gérard


    Although antenna array-based Global Navigation Satellite System (GNSS) receivers can be used to mitigate both narrowband and wideband electronic interference sources, measurement distortions induced by array processing methods are not suitable for high precision applications. The measurement distortions have an adverse effect on the carrier phase ambiguity resolution, affecting the navigation solution. Depending on the array attitude information availability and calibration parameters, different spatial processing methods can be implemented although they distort carrier phase measurements in some cases. This paper provides a detailed investigation of the effect of different array processing techniques on array-based GNSS receiver measurements and navigation performance. The main novelty of the paper is to provide a thorough analysis of array-based GNSS receivers employing different beamforming techniques from tracking to navigation solution. Two beamforming techniques, namely Power Minimization (PM) and Minimum Power Distortionless Response (MPDR), are being investigated. In the tracking domain, the carrier Doppler, Phase Lock Indicator (PLI), and Carrier-to-Noise Ratio (C/N₀) are analyzed. Pseudorange and carrier phase measurement distortions and carrier phase position performance are also evaluated. Performance analyses results from simulated GNSS signals and field tests are provided.

  12. Analytical kinematics analysis and synthesis of planar mechanisms

    CERN Document Server

    Gans, Deborah


    Using computational techniques and a complex variable formulation, this book teaches the student of kinematics to handle increasingly difficult problems in both the analysis and design of mechanisms all based on the fundamental loop closure equation.

  13. Numerical and Analytical Analysis of Elastic Rotor Natural Frequency

    Directory of Open Access Journals (Sweden)

    Adis J. Muminovic


    Full Text Available In this paper simulation model which enables quick analysis of elastic rotor natural frequency modes is developed using Matlab. This simulation model enables users to get dependency diagram of natural frequency in relation to diameter and length of the rotor,density of the material or modulus of elasticity. Testing of the model is done using numerical analysis in SolidWorks software.

  14. Next generation GNSS single receiver cycle slip reliability

    NARCIS (Netherlands)

    Teunissen, P.J.G.; De Bakker, P.F.


    In this contribution we study the multi-frequency, carrier-phase slip detection capabilities of a single receiver. Our analysis is based on an analytical expression that we present for themulti-frequencyminimal detectable carrier phase cycle slip.

  15. Traveling wave analysis of partial differential equations numerical and analytical methods with Matlab and Maple

    CERN Document Server

    Griffiths, Graham


    Although the Partial Differential Equations (PDE) models that are now studied are usually beyond traditional mathematical analysis, the numerical methods that are being developed and used require testing and validation. This is often done with PDEs that have known, exact, analytical solutions. The development of analytical solutions is also an active area of research, with many advances being reported recently, particularly traveling wave solutions for nonlinear evolutionary PDEs. Thus, the current development of analytical solutions directly supports the development of numerical methods by p

  16. Error-analysis and comparison to analytical models of numerical waveforms produced by the NRAR Collaboration

    CERN Document Server

    Hinder, Ian; Boyle, Michael; Etienne, Zachariah B; Healy, James; Johnson-McDaniel, Nathan K; Nagar, Alessandro; Nakano, Hiroyuki; Pan, Yi; Pfeiffer, Harald P; Pürrer, Michael; Reisswig, Christian; Scheel, Mark A; Sperhake, Ulrich; Szilágyi, Bela; Tichy, Wolfgang; Wardell, Barry; Zenginoglu, Anıl; Alic, Daniela; Bernuzzi, Sebastiano; Bode, Tanja; Brügmann, Bernd; Buchman, Luisa T; Campanelli, Manuela; Chu, Tony; Damour, Thibault; Grigsby, Jason D; Hannam, Mark; Haas, Roland; Hemberger, Daniel A; Husa, Sascha; Kidder, Lawrence E; Laguna, Pablo; London, Lionel; Lovelace, Geoffrey; Lousto, Carlos O; Marronetti, Pedro; Matzner, Richard A; Mösta, Philipp; Mroué, Abdul; Müller, Doreen; Mundim, Bruno C; Nerozzi, Andrea; Paschalidis, Vasileios; Pollney, Denis; Reifenberger, George; Rezzolla, Luciano; Shapiro, Stuart L; Shoemaker, Deirdre; Taracchini, Andrea; Taylor, Nicholas W; Teukolsky, Saul A; Thierfelder, Marcus; Witek, Helvi; Zlochower, Yosef


    The Numerical-Relativity-Analytical-Relativity (NRAR) collaboration is a joint effort between members of the numerical relativity, analytical relativity and gravitational-wave data analysis communities. The goal of the NRAR collaboration is to produce numerical-relativity simulations of compact binaries and use them to develop accurate analytical templates for the LIGO/Virgo Collaboration to use in detecting gravitational-wave signals and extracting astrophysical information from them. We describe the results of the first stage of the NRAR project, which focused on producing an initial set of numerical waveforms from binary black holes with moderate mass ratios and spins, as well as one non-spinning binary configuration which has a mass ratio of 10. All of the numerical waveforms are analysed in a uniform and consistent manner, with numerical errors evaluated using an analysis code created by members of the NRAR collaboration. We compare previously-calibrated, non-precessing analytical waveforms, notably the ...

  17. Performance Analysis of a Free Space Optics Link with Multiple Transmitters/Receivers

    Directory of Open Access Journals (Sweden)

    Nur Haedzerin Md Noor


    Full Text Available ABSTRACT:  Multiple transmitters/receivers (TX/RX are used to improve the quality of Free Space Optics (FSO communication systems. With the current needs of this technology for longer distance communication, the qualitative analysis of the system has become essential. In this work, the received power level (PR and bit error rate (BER are considered to influence the FSO link performance. The relationship between the two parameters are investigated and analysed. Furthermore, the received power for various numbers of TXs and RXs are experimentally measured and compared with the values obtained from theoretical calculations. The first part of the work deals with the theoretical calculation and simulation designs of multiple laser beams based on the commercial FSO used in actual sites. The second part describes the practical work and analysis of the system’s performance.ABSTRAK: Pemancar/penerima berganda (TX/RX digunakan bagi meningkatkan kualiti sistem komunikasi Ruang Optik Bebas (FSO. Analisis kualitatif ke atas sistemnya adalah penting bagi keperluan semasa teknologi ini untuk jarak jauh. Di dalam kajian ini, aras kuasa penerima (PR dan kadar ralat bit (BER telah diambilkira bagi menentukan prestasi rangkaian FSO. Hubungan di antara kedua-dua parameter telah dikaji dan dianalisis. Seterusnya, kuasa penerima untuk pelbagai nombor TXs dan RXs diukur secara eksperimen dan dibandingkan dengan nilai teori yang dikira. Bahagian pertama skop kajian berkaitan dengan pengiraan teori dan rekabentuk simulasi sinaran laser berdasarkan FSO komersial di lapangan. Bahagian kedua kajian adalah kerja lapangan dan analisis prestasi sistem.KEY WORDS:  Free Space Optics (FSO link; Multiple TX/RX FSO; bit error rate (BER; eye diagram.

  18. Shotgun lipidomic analysis of chemically sulfated sterols compromises analytical sensitivity

    DEFF Research Database (Denmark)

    Casanovas, Albert; Hannibal-Bach, Hans Kristian; Jensen, Ole Nørregaard


    Fourier transform mass spectrometry (FTMS) for identification and quantification of lipid species [6]. Shotgun lipidomics affords extensive lipidome coverage by combining the analysis of lipid extracts in positive and negative ion mode [1, 3]. Notably, sterols such as cholesterol and ergosterol exhibit...

  19. Stochastic Analysis of Offshore Steel Structures An Analytical Appraisal

    CERN Document Server

    Karadeniz, Halil


    Stochastic Analysis of Offshore Steel Structures provides a clear and detailed guide to advanced analysis methods of fixed offshore steel structures using 3D beam finite elements under random wave and earthquake loadings. Advanced and up-to-date research results are coupled with modern analysis methods and essential theoretical information to consider optimal solutions to structural issues. As these methods require and use knowledge of different subject matters, a general introduction to the key areas is provided. This is followed by in-depth explanations supported by design examples, relevant calculations and supplementary material containing related computer programmers. By combining this theoretical and practical approach Stochastic Analysis of Offshore Steel Structures cover a range of key concepts in detail including: ·         The basic principles of standard 3D beam finite elements and special connections, ·         Wave loading - from hydrodynamics to the calculation of wave load...

  20. Whole brain magnetization transfer histogram analysis of pediatric acute lymphoblastic leukemia patients receiving intrathecal methotrexate therapy

    Energy Technology Data Exchange (ETDEWEB)

    Yamamoto, Akira [Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto-shi Kyoto 606-8507 (Japan)]. E-mail:; Miki, Yukio [Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto-shi Kyoto 606-8507 (Japan)]. E-mail:; Adachi, Souichi [Department of Pediatrics, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto-shi Kyoto 606-8507 (Japan)]. E-mail: (and others)


    Background and purpose: The purpose of this prospective study was to evaluate the hypothesis that magnetization transfer ratio (MTR) histogram analysis of the whole brain could detect early and subtle brain changes nonapparent on conventional magnetic resonance imaging (MRI) in children with acute lymphoblastic leukemia (ALL) receiving methotrexate (MTX) therapy. Materials and methods: Subjects in this prospective study comprised 10 children with ALL (mean age, 6 years; range, 0-16 years). In addition to conventional MRI, magnetization transfer images were obtained before and after intrathecal and intravenous MTX therapy. MTR values were calculated and plotted as a histogram, and peak height and location were calculated. Differences in peak height and location between pre- and post-MTX therapy scans were statistically analyzed. Conventional MRI was evaluated for abnormal signal area in white matter. Results: MTR peak height was significantly lower on post-MTX therapy scans than on pre-MTX therapy scans (p = 0.002). No significant differences in peak location were identified between pre- and post-chemotherapy imaging. No abnormal signals were noted in white matter on either pre- or post-MTX therapy conventional MRI. Conclusions: This study demonstrates that MTR histogram analysis allows better detection of early and subtle brain changes in ALL patients who receive MTX therapy than conventional MRI.

  1. An Improved Time-Frequency Analysis Method in Interference Detection for GNSS Receivers. (United States)

    Sun, Kewen; Jin, Tian; Yang, Dongkai


    In this paper, an improved joint time-frequency (TF) analysis method based on a reassigned smoothed pseudo Wigner-Ville distribution (RSPWVD) has been proposed in interference detection for Global Navigation Satellite System (GNSS) receivers. In the RSPWVD, the two-dimensional low-pass filtering smoothing function is introduced to eliminate the cross-terms present in the quadratic TF distribution, and at the same time, the reassignment method is adopted to improve the TF concentration properties of the auto-terms of the signal components. This proposed interference detection method is evaluated by experiments on GPS L1 signals in the disturbing scenarios compared to the state-of-the-art interference detection approaches. The analysis results show that the proposed interference detection technique effectively overcomes the cross-terms problem and also preserves good TF localization properties, which has been proven to be effective and valid to enhance the interference detection performance of the GNSS receivers, particularly in the jamming environments.

  2. Experimental and Analytical Analysis of Perforated Plate Aerodynamics

    Institute of Scientific and Technical Information of China (English)

    Jürgen Zierep; Rainer Bohning; Piotr Doerffer


    Perforated walls and transpiration flow play an important role in aerodynamics due to an increasing interest in application of flow control by means of blowing and/or suction. An experimental study was carried out which has led to the determination of a transpiration flow characteristics in the form of a simple formula that is very useful in modelling such flows. In connection to this relation a method of "aerodynamic porosity" determination has been proposed which is much more reliable than geometric description of the porosity. A theoretical analysis of the flow through a perforation hole was also carried out. The flow was considered as compressible and viscous. The gasdynamic analysis led us to a very similar result to the relation obtained from the experiment. The adequacy of the theoretical result is discussed in respect to the experiment.



    Ranjeet Mithari; Amar Patil; Prof. E. N. Aitavade


    Leaf spring are of the oldest suspension component they are still frequently used. The current leaf spring is multiple leaf spring types with a steel material. It has high weight, low natural frequency, high corrosion, more noise. Therefore current multiple leaf spring is replaced by mono composite (E- Glass epoxy) leaf spring which has high natural frequency, low weight etc. The maximum stress produced at the cylindrically joint than fixed joint. Therefore stress analysis of composite materi...

  4. BIG Data Analytics: A Framework for Unstructured Data Analysis

    Directory of Open Access Journals (Sweden)

    P.Mohan Kumar


    Full Text Available Nowadays, most of information saved in companies are unstructured models. Retrieval and extraction of the information is essential works and importance in semantic web areas. Many of these requirements will be depend on the unstructured data analysis. More than 80% of all potentially useful business information is unstructured data, in kind of sensor readings, console logs and so on. The large number and complexity of unstructured data opens up many new possibilities for the analyst. Text mining and natural language processing are two techniques with their methods for knowledge discovery from textual context in documents. This is an approach to organize a complex unstructured data and to retrieve necessary information. The paper is to find an efficient way of storing unstructured data and appropriate approach of fetching data. Unstructured data targeted in this work to organize, is the publictweets of Twitter. Building an Big Data application that gets stream of public tweets from twitter which is latter stored in the HBase using Hadoop cluster and followed by data analysis for data retrieved from HBase by REST calls is the pragmatic approach of this project.

  5. A conflict of analysis: analytical chemistry and milk adulteration in Victorian Britain. (United States)

    Steere-Williams, Jacob


    This article centres on a particularly intense debate within British analytical chemistry in the late nineteenth century, between local public analysts and the government chemists of the Inland Revenue Service. The two groups differed in both practical methodologies and in the interpretation of analytical findings. The most striking debates in this period were related to milk analysis, highlighted especially in Victorian courtrooms. It was in protracted court cases, such as the well known Manchester Milk Case in 1883, that analytical chemistry was performed between local public analysts and the government chemists, who were often both used as expert witnesses. Victorian courtrooms were thus important sites in the context of the uneven professionalisation of chemistry. I use this tension to highlight what Christopher Hamlin has called the defining feature of Victorian public health, namely conflicts of professional jurisdiction, which adds nuance to histories of the struggle of professionalisation and public credibility in analytical chemistry.

  6. [Receiver operating characteristic analysis and the cost--benefit analysis in determination of the optimal cut-off point]. (United States)

    Vránová, J; Horák, J; Krátká, K; Hendrichová, M; Kovaírková, K


    An overview of the use of Receiver Operating Characteristic (ROC) analysis within medicine is provided. A survey of the theory behind the analysis is offered together with a presentation on how to create a ROC curve and how to use Cost--Benefit analysis to determine the optimal cut-off point or threshold. The use of ROC analysis is exemplified in the "Cost--Benefit analysis" section of the paper. In these examples, it can be seen that the determination of the optimal cut-off point is mainly influenced by the prevalence and the severity of the disease, by the risks and adverse events of treatment or the diagnostic testing, by the overall costs of treating true and false positives (TP and FP), and by the risk of deficient or non-treatment of false negative (FN) cases.

  7. An introduction to clinical microeconomic analysis: purposes and analytic methods. (United States)

    Weintraub, W S; Mauldin, P D; Becker, E R


    The recent concern with health care economics has fostered the development of a new discipline that is generally called clinical microeconomics. This is a discipline in which microeconomic methods are used to study the economics of specific medical therapies. It is possible to perform stand alone cost analyses, but more profound insight into the medical decision making process may be accomplished by combining cost studies with measures of outcome. This is most often accomplished with cost-effectiveness or cost-utility studies. In cost-effectiveness studies there is one measure of outcome, often death. In cost-utility studies there are multiple measures of outcome, which must be grouped together to give an overall picture of outcome or utility. There are theoretical limitations to the determination of utility that must be accepted to perform this type of analysis. A summary statement of outcome is quality adjusted life years (QALYs), which is utility time socially discounted survival. Discounting is used because people value a year of future life less than a year of present life. Costs are made up of in-hospital direct, professional, follow-up direct, and follow-up indirect costs. Direct costs are for medical services. Indirect costs reflect opportunity costs such as lost time at work. Cost estimates are often based on marginal costs, or the cost for one additional procedure of the same type. Finally an overall statistic may be generated as cost per unit increase in effectiveness, such as dollars per QALY.(ABSTRACT TRUNCATED AT 250 WORDS)

  8. Receiving Basin for Offsite Fuels and the Resin Regeneration Facility Safety Analysis Report, Executive Summary

    Energy Technology Data Exchange (ETDEWEB)

    Shedrow, C.B.


    The Safety Analysis Report documents the safety authorization basis for the Receiving Basin for Offsite Fuels (RBOF) and the Resin Regeneration Facility (RRF) at the Savannah River Site (SRS). The present mission of the RBOF and RRF is to continue in providing a facility for the safe receipt, storage, handling, and shipping of spent nuclear fuel assemblies from power and research reactors in the United States, fuel from SRS and other Department of Energy (DOE) reactors, and foreign research reactors fuel, in support of the nonproliferation policy. The RBOF and RRF provide the capability to handle, separate, and transfer wastes generated from nuclear fuel element storage. The DOE and Westinghouse Savannah River Company, the prime operating contractor, are committed to managing these activities in such a manner that the health and safety of the offsite general public, the site worker, the facility worker, and the environment are protected.

  9. Error analysis for semi-analytic displacement derivatives with respect to shape and sizing variables (United States)

    Fenyes, Peter A.; Lust, Robert V.


    Sensitivity analysis is fundamental to the solution of structural optimization problems. Consequently, much research has focused on the efficient computation of static displacement derivatives. As originally developed, these methods relied on analytical representations for the derivatives of the structural stiffness matrix (K) with respect to the design variables (b sub i). To extend these methods for use with complex finite element formulations and facilitate their implementation into structural optimization programs using the general finite element method analysis codes, the semi-analytic method was developed. In this method the matrix the derivative of K/the derivative b sub i is approximated by finite difference. Although it is well known that the accuracy of the semi-analytic method is dependent on the finite difference parameter, recent work has suggested that more fundamental inaccuracies exist in the method when used for shape optimization. Another study has argued qualitatively that these errors are related to nonuniform errors in the stiffness matrix derivatives. The accuracy of the semi-analytic method is investigated. A general framework was developed for the error analysis and then it is shown analytically that the errors in the method are entirely accounted for by errors in delta K/delta b sub i. Furthermore, it is demonstrated that acceptable accuracy in the derivatives can be obtained through careful selection of the finite difference parameter.

  10. [Local Regression Algorithm Based on Net Analyte Signal and Its Application in Near Infrared Spectral Analysis]. (United States)

    Zhang, Hong-guang; Lu, Jian-gang


    Abstract To overcome the problems of significant difference among samples and nonlinearity between the property and spectra of samples in spectral quantitative analysis, a local regression algorithm is proposed in this paper. In this algorithm, net signal analysis method(NAS) was firstly used to obtain the net analyte signal of the calibration samples and unknown samples, then the Euclidean distance between net analyte signal of the sample and net analyte signal of calibration samples was calculated and utilized as similarity index. According to the defined similarity index, the local calibration sets were individually selected for each unknown sample. Finally, a local PLS regression model was built on each local calibration sets for each unknown sample. The proposed method was applied to a set of near infrared spectra of meat samples. The results demonstrate that the prediction precision and model complexity of the proposed method are superior to global PLS regression method and conventional local regression algorithm based on spectral Euclidean distance.

  11. Stability Analysis of Magnetised Neutron Stars - A Semi-analytic Approach

    CERN Document Server

    Herbrik, Marlene


    We implement a semi-analytic approach for stability analysis, addressing the ongoing uncertainty about stability and structure of neutron star magnetic fields. Applying the energy variational principle, a model system is displaced from its equilibrium state. The related energy density variation is set up analytically, whereas its volume integration is carried out numerically. This facilitates the consideration of more realistic neutron star characteristics within the model compared to analytical treatments. At the same time, our method retains the possibility to yield general information about neutron star magnetic field and composition structures that are likely to be stable. In contrast to numerical studies, classes of parametrized systems can be studied at once, finally constraining realistic configurations for interior neutron star magnetic fields. We apply the stability analysis scheme on polytropic and non-barotropic neutron stars with toroidal, poloidal and mixed fields testing their stability in a New...

  12. Comparative analysis of methods for real-time analytical control of chemotherapies preparations. (United States)

    Bazin, Christophe; Cassard, Bruno; Caudron, Eric; Prognon, Patrice; Havard, Laurent


    Control of chemotherapies preparations are now an obligation in France, though analytical control is compulsory. Several methods are available and none of them is presumed as ideal. We wanted to compare them so as to determine which one could be the best choice. We compared non analytical (visual and video-assisted, gravimetric) and analytical (HPLC/FIA, UV/FT-IR, UV/Raman, Raman) methods thanks to our experience and a SWOT analysis. The results of the analysis show great differences between the techniques, but as expected none us them is without defects. However they can probably be used in synergy. Overall for the pharmacist willing to get involved, the implementation of the control for chemotherapies preparations must be widely anticipated, with the listing of every parameter, and remains according to us an analyst's job.

  13. Analytical importance of determination of lipase activity for the express analysis of contamination by heavy metals of sunflower seeds

    Directory of Open Access Journals (Sweden)

    Y. A. Dyachenko


    Full Text Available During the last decades becoming more sharply there is a problem of chemical and environmental monitoring and industrial inspection the content of toxic elements in food raw materials and foodstuff. At the same time there is a need to develop rapid methods, informative, integral, reflecting not only the safety but also the ecological purity of food raw materials. The method of determination of content of toxic elements on activity of its own lipase of in situ (AОL-method in seeds of oil-bearing crops, on the example of sunflower is offered. The system of mathematical assessment of analytical criteria of laboratory test used in clinical laboratory diagnostics was for this purpose adapted. Sunflower seeds in which established the maintenance of toxiferous elements served as an object of a research: Cd, Pb, As, Hg, by atomic absorption method on the KVANT-Z.ETA device. Further tests divided on clear, including high-quality and pollution-free, and polluted - naturally containing toxiferous elements and which are artificially contaminated. Definition of activity of a lipase of seeds was carried out by the standard titrimetric method. Decrease of the activity of enzyme was connected with the maintenance of toxiferous elements. Proceeding from the received results counted an analytical significance (sensitivity, specificity, and predictive value of descriptiveness the positive and negative results of determination of level of maintenance of toxiferous elements in sunflower seeds by the AОL-method. The set values of analytical specificity of a method and predictive value of a positive take at the level of 77.3% and 71.4% respectively, do not allow to use the offered method for the quantitative analysis, however, analytical sensitivity at the level of 86.2% and the predictive value of the negative result at the level of 89.5%, allow to recommend the AOL-method for screening programs of chemical environmental monitoring and technological monitoring of a

  14. Analytical standards production for the analysis of pomegranate anthocyanins by HPLC

    Directory of Open Access Journals (Sweden)

    Manuela Cristina Pessanha de Araújo Santiago


    Full Text Available Pomegranate (Punica granatum L. is a fruit with a long medicinal history, especially due to its phenolic compounds content, such as the anthocyanins, which are reported as one of the most important natural antioxidants. The analysis of the anthocyanins by high performance liquid chromatography (HPLC can be considered as an important tool to evaluate the quality of pomegranate juice. For research laboratories the major challenge in using HPLC for quantitative analyses is the acquisition of high purity analytical standards, since these are expensive and in some cases not even commercially available. The aim of this study was to obtain analytical standards for the qualitative and quantitative analysis of the anthocyanins from pomegranate. Five vegetable matrices (pomegranate flower, jambolan, jabuticaba, blackberry and strawberry fruits were used to isolate each of the six anthocyanins present in pomegranate fruit, using an analytical HPLC scale with non-destructive detection, it being possible to subsequently use them as analytical standards. Furthermore, their identities were confirmed by high resolution mass spectrometry. The proposed procedure showed that it is possible to obtain analytical standards of anthocyanins with a high purity grade (98.0 to 99.9% from natural sources, which was proved to be an economic strategy for the production of standards by laboratories according to their research requirements.

  15. Cancer risk in older people receiving statin therapy: a meta-analysis of randomized controlled trials (United States)

    Liu, Hong-Wei; Bian, Su-Yan; Zhu, Qi-Wei; Zhao, Yue-Xiang


    Background Although statins are well tolerated by most aged people, their potential carcinogenicity is considered as one of the biggest factors limiting the use of statins. The aim of the present study was to determine the risk of cancer in people aged over 60 years receiving statin therapy. Methods A comprehensive search for articles published up to December 2015 was performed, reviews of each randomized controlled trials (RCTs) that compared the effects of statin mono-therapy with placebo on the risk of cancer in people aged > 60 years were conducted and data abstracted. All the included studies were evaluated for publication bias and heterogeneity. Pooled odds ratios (OR) estimates and 95% confidence intervals (CIs) were calculated using the random effects model. Results A total of 12 RCTs, involving 62,927 patients (31,517 in statin therapy group and 31,410 in control group), with a follow-up duration of 1.9–5.4 years, contributed to the analysis. The statin therapy did not affect the overall incidence of cancer (OR = 1.03, 95% CI: 0.94–1.14, P = 0.52); subgroup analyses showed that neither the variety nor the chemical properties of the statins accounted for the incidence of cancer in older people. Conclusions Our meta-analysis findings do not support a potential cancer risk of statin treatment in people over 60 years old. Further targeted researches with a longer follow-up duration are warranted to confirm this issue.

  16. Receiver operating characteristic (ROC) analysis of images reconstructed with iterative expectation maximization algorithms

    Energy Technology Data Exchange (ETDEWEB)

    Takahashi, Yasuyuki; Murase, Kenya [Osaka Medical Coll., Takatsuki (Japan). Graduate School; Higashino, Hiroshi; Sogabe, Ichiro; Sakamoto, Kana


    The quality of images reconstructed by means of the maximum likelihood-expectation maximization (ML-EM) and ordered subset (OS)-EM algorithms, was examined with parameters such as the number of iterations and subsets, then compared with the quality of images reconstructed by the filtered back projection method. Phantoms showing signals inside signals, which mimicked single-photon emission computed tomography (SPECT) images of cerebral blood flow and myocardial perfusion, and phantoms showing signals around the signals obtained by SPECT of bone and tumor were used for experiments. To determine signals for recognition, SPECT images in which the signals could be appropriately recognized with a combination of fewer iterations and subsets of different sizes and densities were evaluated by receiver operating characteristic (ROC) analysis. The results of ROC analysis were applied to myocardial phantom experiments and scintigraphy of myocardial perfusion. Taking the image processing time into consideration, good SPECT images were obtained by OS-EM at iteration No. 10 and subset 5. This study will be helpful for selection of parameters such as the number of iterations and subsets when using the ML-EM or OS-EM algorithms. (author)

  17. MATT: Monitoring, Analysis and Toxicity of Toxaphene: improvement of analytical methods


    De Boer, J.; Klungsøyr, J; Nesje, G.; Meier, S; McHugh, B.; Nixon, E.; Rimkus, G.G.


    The European Research Project MATT (Investigation into the Monitoring, Analysis and Toxicity of Toxaphene) started in 1997 and had the objective to provide information on toxicological risks to the consumer of toxaphene residues in fish from European waters. This report includes information on the analytical block of the project, which comprised three studies.

  18. Social Cognitive Career Theory, Conscientiousness, and Work Performance: A Meta-Analytic Path Analysis (United States)

    Brown, Steven D.; Lent, Robert W.; Telander, Kyle; Tramayne, Selena


    We performed a meta-analytic path analysis of an abbreviated version of social cognitive career theory's (SCCT) model of work performance (Lent, Brown, & Hackett, 1994). The model we tested included the central cognitive predictors of performance (ability, self-efficacy, performance goals), with the exception of outcome expectations. Results…

  19. Critical Discourse Analysis. The Elaboration of a Problem Oriented Discourse Analytic Approach After Foucault

    Directory of Open Access Journals (Sweden)

    Rainer Diaz-Bone


    Full Text Available Abstract: The German discourse researcher Siegfried JÄGER from Duisburg is the first to have published a German-language book about the methodology of discourse analysis after FOUCAULT. JÄGER integrates in his work the discourse analytic work of Jürgen LINK as well as the interdisciplinary discussion carried on in the discourse analytic journal "kultuRRevolution" (Journal for Applied Discourse Analysis. JÄGER and his co-workers were associated with the Duisburger Institute for Language Research and Social Research (DISS, see for 20 years, developing discourse theory and the methodology of discourse analysis. The interview was done via e-mail. It depicts the discourse analytic approach of JÄGER and his co-workers following the works of FOUCAULT and LINK. The interview reconstructs JÄGERs vita and his academic career. Further topics of the interview are the agenda of JÄGERs discourse studies, methodological considerations, the (problematic relationship between FOUCAULDian discourse analysis and (discourses, linguistics, styles and organization of research and questions concerning applied discourse analytic research as a form of critical intervention. URN: urn:nbn:de:0114-fqs0603219

  20. Analysis of a Natural Yellow Dye: An Experiment for Analytical Organic Chemistry

    NARCIS (Netherlands)

    Villela, A.; Derksen, G.C.H.; Beek, van T.A.


    This experiment exposes second-year undergraduate students taking a course in analytical organic chemistry to high-performance liquid chromatography (HPLC) and quantitative analysis using the internal standard method. This is accomplished using the real-world application of natural dyes for textiles

  1. Experimental analysis of THz receiver performance in 80 Gbit/s communication system

    DEFF Research Database (Denmark)

    Jia, Shi; Yu, Xianbin; Hu, Hao


    We experimentally analyze the performance of Schottky mixer-based THz receiver in a high-speed THz wireless transmission system incorporating an ultra-broadband uni-travelling carrier photodiode (UTC-PD) as photo-mixing emitter. The multi-channel photonic THz wireless system operates in the 375–4...... in the receiver however severely affects the receiver bandwidth and induces the performance degradation of THz wireless communication systems....

  2. Validation of an analytical methodology for the quantitative analysis of petroleum hydrocarbons in marine sediment samples

    Directory of Open Access Journals (Sweden)

    Eloy Yordad Companioni Damas


    Full Text Available This work describes a validation of an analytical procedure for the analysis of petroleum hydrocarbons in marine sediment samples. The proposed protocol is able to measure n-alkanes and polycyclic aromatic hydrocarbons (PAH in samples at concentrations as low as 30 ng/g, with a precision better than 15% for most of analytes. The extraction efficiency of fortified sediments varied from 65.1 to 105.6% and 59.7 to 97.8%, for n-alkanes and PAH in the ranges: C16 - C32 and fluoranthene - benzo(apyrene, respectively. The analytical protocol was applied to determine petroleum hydrocarbons in sediments collected from a marine coastal zone.

  3. Numerical analysis of radiation propagation in innovative volumetric receivers based on selective laser melting techniques (United States)

    Alberti, Fabrizio; Santiago, Sergio; Roccabruna, Mattia; Luque, Salvador; Gonzalez-Aguilar, Jose; Crema, Luigi; Romero, Manuel


    Volumetric absorbers constitute one of the key elements in order to achieve high thermal conversion efficiencies in concentrating solar power plants. Regardless of the working fluid or thermodynamic cycle employed, design trends towards higher absorber output temperatures are widespread, which lead to the general need of components of high solar absorptance, high conduction within the receiver material, high internal convection, low radiative and convective heat losses and high mechanical durability. In this context, the use of advanced manufacturing techniques, such as selective laser melting, has allowed for the fabrication of intricate geometries that are capable of fulfilling the previous requirements. This paper presents a parametric design and analysis of the optical performance of volumetric absorbers of variable porosity conducted by means of detailed numerical ray tracing simulations. Sections of variable macroscopic porosity along the absorber depth were constructed by the fractal growth of single-cell structures. Measures of performance analyzed include optical reflection losses from the absorber front and rear faces, penetration of radiation inside the absorber volume, and radiation absorption as a function of absorber depth. The effects of engineering design parameters such as absorber length and wall thickness, material reflectance and porosity distribution on the optical performance of absorbers are discussed, and general design guidelines are given.

  4. Receiver Function Analysis of Strong-motion Stations in Kaohsiung-Pingtung area, Taiwan (United States)

    Lin, Che-Min; Wen, Kuo-Liang; Kuo, Chun-Hsiang; Huang, Jyun-Yan


    The Kaohsiung City and Pingtung County are located in southern Taiwan and bounded on the west side by several active faults. The shallow velocity structure of thick alluvium basin in this area should be delineated to understand the seismic site effect of strong ground motion. Receiver Function (RF) is a conventional technique for studying the structure of the crust and upper mantle beneath the seismometer. But, the RF analysis of high-frequency acceleration seismograms is also proved to be feasible for estimating shallow structures recently. This study applied the RF technique on the Strong-motion records of almost one-hundred TSMIP stations in Kaohsiung-Pingtung area to estimate the shallow shear-wave velocity structures. The averaged RFs of all stations exhibit the obvious variation because of the different geologies and site conditions. After the forward modeling of RFs based on the Genetic Algorithms (GA) searching, the shallow shear-wave velocity structures beneath all the strong-motion stations in the Kaohsiung-Pingtung area were estimated to delineate the iso-depth contour maps of the main formation interfaces and a preliminary shallow 3D velocity model.

  5. Analysis and Comprehensive Analytical Modeling of Statistical Variations in Subthreshold MOSFET's High Frequency Characteristics

    Directory of Open Access Journals (Sweden)

    Rawid Banchuin


    Full Text Available In this research, the analysis of statistical variations in subthreshold MOSFET's high frequency characteristics defined in terms of gate capacitance and transition frequency, have been shown and the resulting comprehensive analytical models of such variations in terms of their variances have been proposed. Major imperfection in the physical level properties including random dopant fluctuation and effects of variations in MOSFET's manufacturing process, have been taken into account in the proposed analysis and modeling. The up to dated comprehensive analytical model of statistical variation in MOSFET's parameter has been used as the basis of analysis and modeling. The resulting models have been found to be both analytic and comprehensive as they are the precise mathematical expressions in terms of physical level variables of MOSFET. Furthermore, they have been verified at the nanometer level by using 65~nm level BSIM4 based benchmarks and have been found to be very accurate with smaller than 5 % average percentages of errors. Hence, the performed analysis gives the resulting models which have been found to be the potential mathematical tool for the statistical and variability aware analysis and design of subthreshold MOSFET based VHF circuits, systems and applications.

  6. Crustal thickness variation beneath the Romanian seismic network from Rayleigh wave dispersion and receiver function analysis (United States)

    Tataru, Dragos; Grecu, Bogdan; Zaharia, Bogdan


    Variations in crustal thickness in Romania where determined by joint inversion of P wave receiver functions (RFs) and Rayleigh wave group velocity dispersion. We present new models of shear wave velocity structure of the crust beneath Romanian broad band stations. The data set consist in more than 500 teleseismic earthquake with epicentral distance between 30° and 95°, magnitude greater than 6 and a signal-to-noise ratio greater than 3 for the P-wave pulse. Most epicenters are situated along the northern Pacific Rim and arrive with backazimuths (BAZs) between 0° and 135° at the Romanian seismic network. We combine receiver functions with fundamental-mode of the Rayleigh wave group velocities to further constrain the shear-wave velocity structure.To extract the group velocities we applied the Multiple Filter Technique analysis to the vertical components of the earthquakes recordings. This technique allowed us to identify the Rayleigh wave fundamental mode and to compute the dispersion curves of the group velocities at periods between 10 and 150 s allowing us to resolve shear wave velocities to a depth of 100 km. The time-domain iterative deconvolution procedure of Ligorrıa and Ammon (1999) was employed to deconvolve the vertical component of the teleseismic P waveforms from the corresponding horizontal components and obtain radial and transverse receiver functions at each broadband station. The data are inverted using a joint, linearized inversion scheme (Hermann, 2002) which accounts for the relative influence of each set of observations, and allows a trade-off between fitting the observations, constructing a smooth model, and matching a priori constraints. The results show a thin crust for stations located inside the Pannonian basin (28-30 km) and a thicker crust for those in the East European Platform (36-40 km). The stations within the Southern and Central Carpathian Orogen are characterized by crustal depths of ~35 km. For stations located in the Northern

  7. Receiver subsystem analysis report (RADL Item 4-1). 10-MWe Solar Thermal Central-Receiver Pilot Plant: solar-facilities design integration

    Energy Technology Data Exchange (ETDEWEB)


    The results are presented of those thermal hydraulic, structural, and stress analyses required to demonstrate that the Receiver design for the Barstow Solar Pilot Plant will satisfy the general design and performance requirements during the plant's design life. Recommendations resulting from those analyses and supporting test programs are presented regarding operation of the receiver. The analyses are limited to receiver subsystem major structural parts (primary tower, receiver unit core support structure), pressure parts (absorber panels, feedwater, condensate and steam piping/components, flash tank, and steam mainfold) and shielding. (LEW)

  8. Analytical stability analysis of periodic systems by Poincaré mappings with application to rotorcraft dynamics

    Directory of Open Access Journals (Sweden)

    Henryk Flashner


    Full Text Available A point mapping analysis is employed to investigate the stability of periodic systems. The method is applied to simplified rotorcraft models. The proposed approach is based on a procedure to obtain an analytical expression for the period-to-period mapping description of system's dynamics, and its dependence on system's parameters. Analytical stability and bifurcation conditions are then determined and expressed as functional relations between important system parameters. The method is applied to investigate the parametric stability of flapping motion of a rotor and the ground resonance problem encountered in rotorcraft dynamics. It is shown that the proposed approach provides very accurate results when compared with direct numerical results which are assumed to be an “exact solution” for the purpose of this study. It is also demonstrated that the point mapping method yields more accurate results than the widely used classical perturbation analysis. The ability to perform analytical stability studies of systems with multiple degrees-of-freedom is an important feature of the proposed approach since most existing analysis methods are applicable to single degree-of-freedom systems. Stability analysis of higher dimensional systems, such as the ground resonance problems, by perturbation methods is not straightforward, and is usually very cumbersome.

  9. Covariate Adjustment in Receiver Operating Characteristic Curve Analysis for PSA in Diagnosis of Prostate Cancer

    Directory of Open Access Journals (Sweden)

    Emre DEMIR


    Full Text Available Objective: Markers which are used for classification into two groups, such as patient / healthy, benign/malignant or prediction of optimal cut off value for diagnostic test and evaluating the performance of diagnostic tests is evaluated by Receiver Operating Characteristic (ROC curve in the diagnostic test researches. In classification accuracy research, some variables such as gender and age, commonly is not similar in groups. In these cases, covariates should be considered to estimate in the area under ROC and covariate adjustment for ROC should be performed. This study aims to introduce methods in the literature for the effect of covariate adjustment and to present an application with sample from the health field. Material and Methods: In the study, we introduced methods used in the literatüre for covariate adjustment and prediction of the area under ROC curves as well as an application with data from the field of urology. In this study, 105 PSA (prostate specific antigen measurements were taken in order to examine the covariate effect for the age variable and to assess the diagnostic performance of PSA measurements with regard to pathologic methods. Results: Covariate effect were found statistically significant with 0.733 parameter estimation of the age in ROC curves analysis with PSA data (p<0.001. According to the methods (Non-parametric (empirical, non-parametric (normal, semi-parametric (empirical, parametric (normal that estimates of the area under ROC curves which is obtained without covariate effect were found 0.708, 0.629, 0.709 and 0.628, respectively, by using PSA measurements. Area under the curve that obtained by covariate adjustment were significantly lower as compared to the traditional ROC with estimation 0.580, 0.577, 0.582 and 0.579. Conclusion: Area under the ROC curves should be estimated with adjustment according to the covariates that could affect the markers value of diagnostic tests performed in concert with matching

  10. Transient analysis of a molten salt central receiver (MSCR) in a solar power plant (United States)

    Joshi, A.; Wang, C.; Akinjiola, O.; Lou, X.; Neuschaefer, C.; Quinn, J.


    Alstom is developing solar power tower plants utilizing molten salt as the working fluid. In solar power tower, the molten salt central receiver (MSCR) atop of the tower is constructed of banks of tubes arranged in panels creating a heat transfer surface exposed to the solar irradiation from the heliostat field. The molten salt heat transfer fluid (HTF), in this case 60/40%wt NaNO3-KNO3, flows in serpentine flow through the surface collecting sensible heat thus raising the HTF temperature from 290°C to 565°C. The hot molten salt is stored and dispatched to produce superheated steam in a steam generator, which in turn produces electricity in the steam turbine generator. The MSCR based power plant with a thermal energy storage system (TESS) is a fully dispatchable renewable power plant with a number of opportunities for operational and economic optimization. This paper presents operation and controls challenges to the MSCR and the overall power plant, and the use of dynamic model computer simulation based transient analyses applied to molten salt based solar thermal power plant. This study presents the evaluation of the current MSCR design, using a dynamic model, with emphasis on severe events affecting critical process response, such as MS temperature deviations, and recommend MSCR control design improvements based on the results. Cloud events are the scope of the transient analysis presented in this paper. The paper presents results from a comparative study to examine impacts or effects on key process variables related to controls and operation of the MSCR plant.

  11. The intracrustal structure beneath the Owyhee Plateau, Oregon, from receiver function analysis (United States)

    Hou, T.; Chen, C.; James, D. E.; Fouch, M. J.


    The Owyhee Plateau straddles southeastern Oregon, southwestern Idaho, and northern Nevada, and is an isolated block of older, and less modified, continental lithosphere relative to bordering geologic terranes. Previous seismic studies have characterized the Owyhee Plateau as having thickened crust with low Poisson's ratio and high intracrustal S-wave velocities, and distinct, albeit thin, mantle lithosphere. Significant tectonomagmatic activity, including extension in the northern Great Basin, and intraplate volcanism is present on the margins of the Plateau, but very little volcanism takes place within the Plateau itself. The volcanism is expressed as two prominent age-progressive volcanic tracks, the Snake River Plains-Yellowstone and the High Lava Plains, both of which appear to have originated from near the Owyhee Plateau at approximately 12 Ma. Recent ambient noise tomography and scattered-wave imaging reveal the presence of irregular high velocity layering in the Owyhee mid-crust, but the extent and properties of this feature, and its role in the tectonic evolution of the Owyhee Plateau, remain elusive. In this study, we perform detailed single station Ps receiver function analysis to better constrain the discontinuity structures within the Owyhee crust. We use teleseismic waveform data recorded at 28 High Lava Plains seismic array and 12 USArray Transportable Array broadband stations from 2006 to 2009. Preliminary results show coherent signals of converted phase at ~20 km depth, indicating the presence of a positive velocity discontinuity, which may mark the upper bound of the high velocity layer imaged in previous studies. We consider and examine possible effects of seismic anisotropy on our results and are also conducting synthetic experiments to further constrain the properties of this feature.

  12. Performance analysis of MRC spatial diversity receiver system for satellite-to-ground downlink optical transmissions (United States)

    Li, Kangning; Ma, Jing; Tan, Liying; Yu, Siyuan; Cao, Yubin


    The performances of satellite-to-ground downlink optical communications over Gamma-Gamma distributed turbulence are studied for multiple apertures receiver system. Maximum ratio combining (MRC) technique is considered as a combining scheme to mitigate the atmospheric turbulence under thermal noise limited conditions. Bit-error rate (BER) performances for on-off keying (OOK) modulated direct detection optical communications are analyzed for MRC diversity receptions through an approximation method. To show the net diversity gain of multiple apertures receiver system, BER performances of MRC receiver system are compared with a single monolithic aperture receiver system with the same total aperture area (same average total incident optical power) for satellite-to-ground downlink optical communications. All the numerical results are also verified by Monte-Carlo (MC) simulations.

  13. Analysis of Using a Heliostat with Non-Rotating Solar Energy Receivers


    Janpavlis, V; Suzdaļenko, A; Stepanovs, A; Dzelzkalēja, L


    The use of solar energy in Northern countries is not as obviously reasonable as in the countries that are located closer to the Equator due to bigger differences of daytime during changes of seasons, as well as lower solar irradiance. This paper investigates the advantages of using a heliostat with non-rotating solar energy receivers (like water/air heating collectors, stationary PV panels or solar illumination collectors). The optimal orientation of the solar receiver and the heliostat is di...

  14. Analysis of parallel optical sampling rate and ADC requirements in digital coherent receivers

    DEFF Research Database (Denmark)

    Lorences Riesgo, Abel; Galili, Michael; Peucheret, Christophe


    We comprehensively assess analog-to-digital converter requirements in coherent digital receiver schemes with parallel optical sampling. We determine the electronic requirements in accordance with the properties of the free running local oscillator.......We comprehensively assess analog-to-digital converter requirements in coherent digital receiver schemes with parallel optical sampling. We determine the electronic requirements in accordance with the properties of the free running local oscillator....

  15. Semi-Analytical Finite Strip Transfer Matrix Method for Buckling Analysis of Rectangular Thin Plates

    Directory of Open Access Journals (Sweden)

    Li-Ke Yao


    Full Text Available Plates and shells are main components of modern engineering structures, whose buckling analysis has been focused by researchers. In this investigation, rectangular thin plates with loaded edges simply supported can be discretized by semi-analytical finite strip technology. Then the control equations of the strip elements of the buckling plate will be rewritten as the transfer equations by transfer matrix method. A new approach, namely semi-analytical Finite Strip Transfer Matrix Method, is developed for the buckling analysis of plates. This method requires no global stiffness matrix of the system, reduces the system matrix order, and improves the computational efficiency. Comparing with some theoretical results and FEM’s results of two illustrations (the plates and the ribbed plates under six boundary conditions, the method is proved to be reliable and effective.

  16. Text Stream Trend Analysis using Multiscale Visual Analytics with Applications to Social Media Systems

    Energy Technology Data Exchange (ETDEWEB)

    Steed, Chad A [ORNL; Beaver, Justin M [ORNL; BogenII, Paul L. [Google Inc.; Drouhard, Margaret MEG G [ORNL; Pyle, Joshua M [ORNL


    In this paper, we introduce a new visual analytics system, called Matisse, that allows exploration of global trends in textual information streams with specific application to social media platforms. Despite the potential for real-time situational awareness using these services, interactive analysis of such semi-structured textual information is a challenge due to the high-throughput and high-velocity properties. Matisse addresses these challenges through the following contributions: (1) robust stream data management, (2) automated sen- timent/emotion analytics, (3) inferential temporal, geospatial, and term-frequency visualizations, and (4) a flexible drill-down interaction scheme that progresses from macroscale to microscale views. In addition to describing these contributions, our work-in-progress paper concludes with a practical case study focused on the analysis of Twitter 1% sample stream information captured during the week of the Boston Marathon bombings.

  17. Biological and Analytical Variation of the Human Sweating Response: Implications for Study Design and Analysis (United States)


    information This infomation is current as of January 24, 2012. ISSN: 0363-6119, ESSN: 1522-1490. Visit our...sweating rate; reproducibility; exercise-heat stress; sweating onset A FUNDAMENTAL CHALLENGE IN the study of human integrative physiology is in the...analysis software. Analytical variation. To determine the ventilated sweat capsule measurement system CVa, measurements of SR were made in an

  18. Studies of Micellar Electrokinetic Chromatography as an Analytical Technique in Pharmaceutical Analysis - an Industrial Perspective


    Stubberud, Karin


    Studies have been performed to evaluate the use of micellar electrokinetic chromatography (MEKC), one mode of capillary electrophoresis (CE), as an analytical technique in industrial pharmaceutical analysis. The potential for using chemometrics for the optimisation of MEKC methods has also been studied as well as the possibilities of coupling MEKC with mass spectrometry (MS). Two methods were developed, one for the determination of ibuprofen and codeine and another for pilocarpine, together ...

  19. Techno-economic analysis of receiver replacement scenarios in a parabolic trough field (United States)

    Röger, Marc; Lüpfert, Eckhard; Caron, Simon; Dieckmann, Simon


    The heat loss of an evacuated parabolic trough receiver of solar thermal power plants ranges typically between values below 150 and 200 W/m at 350°C. Defects, such as glass breakage by wind events and coating degradation, anti-reflection coating degradation or hydrogen accumulation in the annulus, decrease the annual electricity production. This study examines the effect of different receiver performance loss scenarios on the energetic and economic output of a modern 150-MWel-parabolic trough plant with 7.5-hours molten-salt storage, located in Ma'an, Jordan over the whole lifetime by modeling it in an extended version of the software greenius. Compared to the reference scenario, a wind event in year 5 (10, 15) causing glass envelope breakage and consequential degradation of the selective coating of 5.6% of the receivers reduces the electricity output by 5.1% (3.8%, 2.5%), the net present value is reduced by 36.5% (23.1%, 13.1%). The payback time of receiver replacement is only 0.7 years and hence this measure is recommended. The highest negative impact on performance and net present value of a project has the hydrogen accumulation scenario (50% of field affected) in event year 5 (10,15) reducing net electric output by 10.7% (8.1%, 5.4%) and the net present value by 77.0% (48.7%, 27.6%). Replacement of the receivers or even better an inexpensive repair solution is an energetically and economically sensible solution. The option of investing in premium receivers with Xe-capsule during the construction phase is a viable option if the surplus cost for premium receivers is lower than 10 to 20 percent.

  20. Analysis and Compensation of Transmitter and Receiver I/Q Imbalances in Space-Time Coded Multiantenna OFDM Systems

    Directory of Open Access Journals (Sweden)

    Zou Yaning


    Full Text Available Abstract The combination of orthogonal frequency division multiplexing (OFDM and multiple-input multiple-output (MIMO techniques has been widely considered as the most promising approach for building future wireless transmission systems. The use of multiple antennas poses then big restrictions on the size and cost of individual radio transmitters and receivers, to keep the overall transceiver implementation feasible. This results in various imperfections in the analog radio front ends. One good example is the so-called I/Q imbalance problem related to the amplitude and phase matching of the transceiver I and Q chains. This paper studies the performance of space-time coded (STC multiantenna OFDM systems under I/Q imbalance, covering both the transmitter and the receiver sides of the link. The challenging case of frequency-selective I/Q imbalances is assumed, being an essential ingredient in future wideband wireless systems. As a practical example, the Alamouti space-time coded OFDM system with two transmit and M receive antennas is examined in detail and a closed-form solution for the resulting signal-to-interference ratio (SIR at the detector input due to I/Q imbalance is derived. This offers a valuable analytical tool for assessing the I/Q imbalance effects in any STC-OFDM system, without lengthy data or system simulations. In addition, the impact of I/Q imbalances on the channel estimation in the STC-OFDM context is also analyzed analytically. Furthermore, based on the derived signal models, a practical pilot-based I/Q imbalance compensation scheme is also proposed, being able to jointly mitigate the effects of frequency-selective I/Q imbalances as well as channel estimation errors. The performance of the compensator is analyzed using extensive computer simulations, and it is shown to virtually reach the perfectly matched reference system performance with low pilot overhead.

  1. Analysis and Compensation of Transmitter and Receiver I/Q Imbalances in Space-Time Coded Multiantenna OFDM Systems

    Directory of Open Access Journals (Sweden)

    Yaning Zou


    Full Text Available The combination of orthogonal frequency division multiplexing (OFDM and multiple-input multiple-output (MIMO techniques has been widely considered as the most promising approach for building future wireless transmission systems. The use of multiple antennas poses then big restrictions on the size and cost of individual radio transmitters and receivers, to keep the overall transceiver implementation feasible. This results in various imperfections in the analog radio front ends. One good example is the so-called I/Q imbalance problem related to the amplitude and phase matching of the transceiver I and Q chains. This paper studies the performance of space-time coded (STC multiantenna OFDM systems under I/Q imbalance, covering both the transmitter and the receiver sides of the link. The challenging case of frequency-selective I/Q imbalances is assumed, being an essential ingredient in future wideband wireless systems. As a practical example, the Alamouti space-time coded OFDM system with two transmit and M receive antennas is examined in detail and a closed-form solution for the resulting signal-to-interference ratio (SIR at the detector input due to I/Q imbalance is derived. This offers a valuable analytical tool for assessing the I/Q imbalance effects in any STC-OFDM system, without lengthy data or system simulations. In addition, the impact of I/Q imbalances on the channel estimation in the STC-OFDM context is also analyzed analytically. Furthermore, based on the derived signal models, a practical pilot-based I/Q imbalance compensation scheme is also proposed, being able to jointly mitigate the effects of frequency-selective I/Q imbalances as well as channel estimation errors. The performance of the compensator is analyzed using extensive computer simulations, and it is shown to virtually reach the perfectly matched reference system performance with low pilot overhead.

  2. An advanced complex analysis problem book topological vector spaces, functional analysis, and Hilbert spaces of analytic functions

    CERN Document Server

    Alpay, Daniel


    This is an exercises book at the beginning graduate level, whose aim is to illustrate some of the connections between functional analysis and the theory of functions of one variable. A key role is played by the notions of positive definite kernel and of reproducing kernel Hilbert space. A number of facts from functional analysis and topological vector spaces are surveyed. Then, various Hilbert spaces of analytic functions are studied.

  3. Investigation of Lab Fire Prevention Management System of Combining Root Cause Analysis and Analytic Hierarchy Process with Event Tree Analysis


    Cheng-Chan Shih; Horng, Richard S.; Shin-Ku Lee


    This paper proposed a new approach, combining root cause analysis (RCA), analytic hierarchy process (AHP), and event tree analysis (ETA) in a loop to systematically evaluate various laboratory safety prevention strategies. First, 139 fire accidents were reviewed to identify the root causes and draw out prevention strategies. Most fires were caused due to runaway reactions, operation error and equipment failure, and flammable material release. These mostly occurred in working places of no prom...

  4. Exact capture probability analysis of GSC receivers over Rayleigh fading channel

    KAUST Repository

    Nam, Sungsik


    For third generation systems and ultrawideband systems, RAKE receivers have been introduced due to the advantage of RAKE receivers which is their ability to combine different replicas of the transmitted signal arriving at different delays in a rich multipath environment. In principle, RAKE receivers combine all resolvable paths which gives the best performance in a rich diversity environment. However, this is usually costly in terms of hardware required as the number of RAKE fingers increases. Therefore, generalized selection combining (GSC) RAKE reception was proposed and has been studied by many researcher as an alternative to the classical two fundamental diversity schemes: maximal ratio combining and selection combining. Previous work on performance analyses of GSC RAKE receivers based on the signal to noise ratio focused on the development of methodologies to derive exact closedform expressions for various performance measures. However, the remaining set of uncombined paths affect the overall performance both in terms of loss in power. Therefore, to have a full understanding of the performance of GSC RAKE receivers, we introduce in this paper the notion of capture probability, which is defined as the ratio of the captured power (essentially combined paths power) to that of the total available power. The major difficulty in these problems is to derive some joint statistics of ordered exponential variates. With this motivation in mind, we capitalize in this paper on some new order statistics results to derive exact closed-form expressions for the capture probability over independent and identically distributed Rayleigh fading channels. © 2010 IEEE.

  5. Analytical Round Robin for Elastic-Plastic Analysis of Surface Cracked Plates: Phase I Results (United States)

    Wells, D. N.; Allen, P. A.


    An analytical round robin for the elastic-plastic analysis of surface cracks in flat plates was conducted with 15 participants. Experimental results from a surface crack tension test in 2219-T8 aluminum plate provided the basis for the inter-laboratory study (ILS). The study proceeded in a blind fashion given that the analysis methodology was not specified to the participants, and key experimental results were withheld. This approach allowed the ILS to serve as a current measure of the state of the art for elastic-plastic fracture mechanics analysis. The analytical results and the associated methodologies were collected for comparison, and sources of variability were studied and isolated. The results of the study revealed that the J-integral analysis methodology using the domain integral method is robust, providing reliable J-integral values without being overly sensitive to modeling details. General modeling choices such as analysis code, model size (mesh density), crack tip meshing, or boundary conditions, were not found to be sources of significant variability. For analyses controlled only by far-field boundary conditions, the greatest source of variability in the J-integral assessment is introduced through the constitutive model. This variability can be substantially reduced by using crack mouth opening displacements to anchor the assessment. Conclusions provide recommendations for analysis standardization.

  6. BER analysis of IM/DD FSO system with APD receiver over gamma-gamma turbulence

    Directory of Open Access Journals (Sweden)

    Petković Milica I.


    Full Text Available In this paper, the bit-error rate (BER performance of intensity modulated with direct detection (IM/DD free space optical (FSO system using the on-off keying (OOK and avalanche photodiode (APD receiver is analyzed. The intensity fluctuations of the received optical signal are modeled by gamma gamma distribution, while both zero and nonzero inner scale models are observed. The total receiver noise includes APD shot noise and thermal noise. The BER expression is theoretically derived and numerical results are presented. The results illustrate the BER dependence on the turbulence strength, propagation path length, APD gain and noise temperature. [Projekat Ministarstva nauke Republike Srbije, br. TR-32028 i br. III-44006

  7. A brief history of free-response receiver operating characteristic paradigm data analysis. (United States)

    Chakraborty, Dev P


    In the receiver operating characteristic paradigm the observer assigns a single rating to each image and the location of the perceived abnormality, if any, is ignored. In the free-response receiver operating characteristic paradigm the observer is free to mark and rate as many suspicious regions as are considered clinically reportable. Credit for a correct localization is given only if a mark is sufficiently close to an actual lesion; otherwise, the observer's mark is scored as a location-level false positive. Until fairly recently there existed no accepted method for analyzing the resulting relatively unstructured data containing random numbers of mark-rating pairs per image. This report reviews the history of work in this field, which has now spanned more than five decades. It introduces terminology used to describe the paradigm, proposed measures of performance (figures of merit), ways of visualizing the data (operating characteristics), and software for analyzing free-response receiver operating characteristic studies.

  8. Dynamics of Caribbean and Nazca Plate Subduction Beneath Colombia from Receiver Function Analysis (United States)

    Porter, R. C.; Warren, L. M.


    The tectonics of northwestern South America are controlled by the complex interactions of the South American, Nazca, and Caribbean plates. In order to better understand subduction within the region, we utilize data recorded by the Colombian National Seismic Network to calculate P-to-S receiver functions at a range of frequencies across the nation of Colombia. Where the station spacing was dense enough, receiver functions were stacked using the Common Conversion Point (CCP) method in order to better image lateral changes in crustal and upper mantle structure. Along the Pacific margin of Colombia, where the Nazca plate is subducting beneath South America, the subducting slab dips too steeply to image it with receiver functions. However, layering and strong negative arrivals are observed in the crust above the subducting slab where active volcanoes are present. The presence of these arrivals is possibly indicative of slab dehydration and the presence of partial melt within the crust. In northeastern Colombia, the Caribbean plate is subducting beneath South America at an oblique angle. Along the direction of convergence, the slab extends ~500 km inland with a relatively shallow dip before steepening. Preliminary receiver function images from this region show a shallowly-dipping negative arrival, interpreted as the top of the slab. This arrival is underlain by a positive conversion, interpreted as the down-going oceanic Moho. As the dip of the seismicity associated with the subducting slab steepens, these arrivals are no longer observed within the receiver function stacks. These cross sections of the Caribbean plate subduction are consistent with the idea that phase changes within the downgoing oceanic crust and mantle are controlling the slab buoyancy and, as a result, the angle of subduction. As the receiver functions are refined and further combined with local earthquake locations, we will better be able to understand the location of earthquakes within the subducting

  9. Approximate analytical solution of diffusion equation with fractional time derivative using optimal homotopy analysis method

    Directory of Open Access Journals (Sweden)

    S. Das


    Full Text Available In this article, optimal homotopy-analysis method is used to obtain approximate analytic solution of the time-fractional diffusion equation with a given initial condition. The fractional derivatives are considered in the Caputo sense. Unlike usual Homotopy analysis method, this method contains at the most three convergence control parameters which describe the faster convergence of the solution. Effects of parameters on the convergence of the approximate series solution by minimizing the averaged residual error with the proper choices of parameters are calculated numerically and presented through graphs and tables for different particular cases.

  10. Performance Analysis of Ultra Wideband Receivers for High Data Rate Wireless Personal Area Network System

    CERN Document Server

    Das, Bikramaditya; 10.5121/jgraphhoc.2010.2104


    For high data rate ultra wideband communication system, performance comparison of Rake, MMSE and Rake-MMSE receivers is attempted in this paper. Further a detail study on Rake-MMSE time domain equalizers is carried out taking into account all the important parameters such as the effect of the number of Rake fingers and equalizer taps on the error rate performance. This receiver combats inter-symbol interference by taking advantages of both the Rake and equalizer structure. The bit error rate performances are investigated using MATLAB simulation on IEEE 802.15.3a defined UWB channel models. Simulation results show that the bit error rate probability of Rake-MMSE receiver is much better than Rake receiver and MMSE equalizer. Study on non-line of sight indoor channel models illustrates that bit error rate performance of Rake-MMSE (both LE and DFE) improves for CM3 model with smaller spread compared to CM4 channel model. It is indicated that for a MMSE equalizer operating at low to medium SNR values, the number o...

  11. Stress Analysis and Evaluating of 841BB03 Receiving Tank Ⅱ

    Institute of Scientific and Technical Information of China (English)

    WANG; Jun; DAI; Shou-tong; JING; Dan


    Entrusted by China Nuclear Engineer Ltd.,we’ve analyzed and evaluated the stress of Type 841BB03receiving tankⅡthat is one of the high level radioactive waste vitrification process equipments in 821 Plant.The equipment evaluated is classified as safety,radiochemical ClassⅠ,anti-seismic TypeⅠ.

  12. Performance Analysis of Ultra Wideband Receivers for High Data Rate Wireless Personal Area Network System

    Directory of Open Access Journals (Sweden)

    Bikramaditya Das


    Full Text Available For high data rate ultra wideband communication system, performance comparison of Rake, MMSE andRake-MMSE receivers is attempted in this paper. Further a detail study on Rake-MMSE time domainequalizers is carried out taking into account all the important parameters such as the effect of the numberof Rake fingers and equalizer taps on the error rate performance. This receiver combats inter-symbolinterference by taking advantages of both the Rake and equalizer structure. The bit error rateperformances are investigated using MATLAB simulation on IEEE 802.15.3a defined UWB channelmodels. Simulation results show that the bit error rate probability of Rake-MMSE receiver is much betterthan Rake receiver and MMSE equalizer. Study on non-line of sight indoor channel models illustratesthat bit error rate performance of Rake-MMSE (both LE and DFE improves for CM3 model with smallerspread compared to CM4 channel model. It is indicated that for a MMSE equalizer operating at low tomedium SNR values, the number of Rake fingers is the dominant factor to improve system performance,while at high SNR values the number of equalizer taps plays a more significant role in reducing the errorrate.

  13. Assessing the Classification Accuracy of Early Numeracy Curriculum-Based Measures Using Receiver Operating Characteristic Curve Analysis (United States)

    Laracy, Seth D.; Hojnoski, Robin L.; Dever, Bridget V.


    Receiver operating characteristic curve (ROC) analysis was used to investigate the ability of early numeracy curriculum-based measures (EN-CBM) administered in preschool to predict performance below the 25th and 40th percentiles on a quantity discrimination measure in kindergarten. Areas under the curve derived from a sample of 279 students ranged…

  14. Homotopy Analysis Method:A new Analytical Technique for Non—linear Problems

    Institute of Scientific and Technical Information of China (English)



    In this paper,the basic ideas of a new kind of analytical technique,namely the Homotopy Analysis Method(HAM),are briefly described.Different from perturbation techniques,the HAM does not depend on whether or not there exist small parameters in non-linear equations under consideration.Therefore,it provides us with a powerful tool to analyse strongly nonlinear problems.A simple but typical example is used to illustrate the validity and the great potential of the HAM.Moreover,a pure mathematical theorem,namely the General Taylor Theorem,is given in appendix,which provides us with some rational knowldge for the validity of this new analytical technique.

  15. Dynamic buckling analysis of delaminated composite plates using semi-analytical finite strip method (United States)

    Ovesy, H. R.; Totounferoush, A.; Ghannadpour, S. A. M.


    The delamination phenomena can become of paramount importance when the design of the composite plates is concerned. In the current study, the effect of through-the-width delamination on dynamic buckling behavior of a composite plate is studied by implementing semi-analytical finite strip method. In this method, the energy and work integrations are computed analytically due to the implementation of trigonometric functions. Moreover, the method can lead to converged results with comparatively small number of degrees of freedom. These features have made the method quite efficient. To account for delamination effects, displacement field is enriched by adding appropriate terms. Also, the penetration of the delamination surfaces is prevented by incorporating an appropriate contact scheme into the time response analysis. Some selected results are validated against those available in the literature.

  16. An analytical method for the ditching analysis of an airborne vehicle (United States)

    Ghaffari, Farhad


    A simple analytical method has been introduced for aerohydrodynamic load analysis of an airborne configuration during water ditching. The method employs an aerodynamic panel code, based on linear potential flow theory, to simulate the flow of air and water around an aircraft configuration. The free surface separating the air and water region is represented by doublet sheet singularities. Although all the theoretical load distributions are computed for air, provisions are made to correct the pressure coefficients obtained on the configuration wetted surfaces to account for the water density. As an analytical tool, the Vortex Separation Aerodynamic (VSAERO) code is chosen to carry out the present investigation. After assessing the validity of the method, its first application is to analyze the water ditching of the Space Shuttle configuration at a 12 degree attitude.

  17. Modeling of closed-loop recycling liquid-liquid chromatography: Analytical solutions and model analysis. (United States)

    Kostanyan, Artak E


    In closed-loop recycling (CLR) chromatography, the effluent from the outlet of a column is directly returned into the column through the sample feed line and continuously recycled until the required separation is reached. To select optimal operating conditions for the separation of a given feed mixture, an appropriate mathematical description of the process is required. This work is concerned with the analysis of models for the CLR separations. Due to the effect of counteracting mechanisms on separation of solutes, analytical solutions of the models could be helpful to understand and optimize chromatographic processes. The objective of this work was to develop analytical expressions to describe the CLR counter-current (liquid-liquid) chromatography (CCC). The equilibrium dispersion and cell models were used to describe the transport and separation of solutes inside a CLR CCC column. The Laplace transformation is applied to solve the model equations. Several possible CLR chromatography methods for the binary and complex mixture separations are simulated.

  18. Space Trajectories Error Analysis (STEAP) Programs. Volume 1: Analytic manual, update (United States)


    Manual revisions are presented for the modified and expanded STEAP series. The STEAP 2 is composed of three independent but related programs: NOMAL for the generation of n-body nominal trajectories performing a number of deterministic guidance events; ERRAN for the linear error analysis and generalized covariance analysis along specific targeted trajectories; and SIMUL for testing the mathematical models used in the navigation and guidance process. The analytic manual provides general problem description, formulation, and solution and the detailed analysis of subroutines. The programmers' manual gives descriptions of the overall structure of the programs as well as the computational flow and analysis of the individual subroutines. The user's manual provides information on the input and output quantities of the programs. These are updates to N69-36472 and N69-36473.

  19. Implementation Recommendations for MOSAIC: A Workflow Architecture for Analytic Enrichment. Analysis and Recommendations for the Implementation of a Cohesive Method for Orchestrating Analytics in a Distributed Model (United States)


    recognition and genre detection. This analytic work must happen before any of the active workflows execute on the incoming document, so it is...documents of a particular language or genre and this information must be made available to all of them up front. Any further or deeper analysis should...of the structure of an Item to us, but still leaves the location of the document text a mystery . We did some exploring by using the GUI to create a

  20. Effects of Joint Controller on Analytical Modal Analysis of Rotational Flexible Manipulator

    Institute of Scientific and Technical Information of China (English)

    CHU Ming; ZHANG Yanheng; CHEN Gang; SUN Hanxu


    Modal analysis is a fundamental and important task for modeling and control of the flexible manipulator. However, almost all of the traditional modal analysis methods view the flexible manipulator as a pure mechanical structure and neglect feedback action of joint controller. In order to study the effects of joint controller on the modal analysis of rotational flexible manipulator, a closed-loop analytical modal analysis method is proposed. Firstly, two exact boundary constralnts, namely servo feedback constralnt and bending moment constralnt, are derived to solve the vibration partial differential equation. It is found that the stiffness and damping galns of joint controller are both included in the boundary conditions, which lead to an unconventional secular term. Secondly, analytical algorithm based on Ritz approach is developed by using Laplace transform and complex modal approach to obtaln the natural frequencies and mode shapes. And then, the numerical simulations are performed and the computational results show that joint controller has pronounced influence on the modal parameters:joint controller stiffness reduces the natural frequency, while joint controller damping makes the shape phase non-zero. Furthermore, the validity of the presented conclusion is confirmed through experimental studies. These findings are expected to improve the performance of dynamics simulation systems and model-based controllers.

  1. Improvement of analytical capabilities of neutron activation analysis laboratory at the Colombian Geological Survey (United States)

    Parrado, G.; Cañón, Y.; Peña, M.; Sierra, O.; Porras, A.; Alonso, D.; Herrera, D. C.; Orozco, J.


    The Neutron Activation Analysis (NAA) laboratory at the Colombian Geological Survey has developed a technique for multi-elemental analysis of soil and plant matrices, based on Instrumental Neutron Activation Analysis (INAA) using the comparator method. In order to evaluate the analytical capabilities of the technique, the laboratory has been participating in inter-comparison tests organized by Wepal (Wageningen Evaluating Programs for Analytical Laboratories). In this work, the experimental procedure and results for the multi-elemental analysis of four soil and four plant samples during participation in the first round on 2015 of Wepal proficiency test are presented. Only elements with radioactive isotopes with medium and long half-lives have been evaluated, 15 elements for soils (As, Ce, Co, Cr, Cs, Fe, K, La, Na, Rb, Sb, Sc, Th, U and Zn) and 7 elements for plants (Br, Co, Cr, Fe, K, Na and Zn). The performance assessment by Wepal based on Z-score distributions showed that most results obtained |Z-scores| ≤ 3.

  2. GNSS software receiver sampling noise and clock jitter performance and impact analysis (United States)

    Chen, Jian Yun; Feng, XuZhe; Li, XianBin; Wu, GuangYao


    In the design of a multi-frequency multi-constellation GNSS software defined radio receivers is becoming more and more popular due to its simple architecture, flexible configuration and good coherence in multi-frequency signal processing. It plays an important role in navigation signal processing and signal quality monitoring. In particular, GNSS software defined radio receivers driving the sampling clock of analogue-to-digital converter (ADC) by FPGA implies that a more flexible radio transceiver design is possible. According to the concept of software defined radio (SDR), the ideal is to digitize as close to the antenna as possible. Whereas the carrier frequency of GNSS signal is of the frequency of GHz, converting at this frequency is expensive and consumes more power. Band sampling method is a cheaper, more effective alternative. When using band sampling method, it is possible to sample a RF signal at twice the bandwidth of the signal. Unfortunately, as the other side of the coin, the introduction of SDR concept and band sampling method induce negative influence on the performance of the GNSS receivers. ADC's suffer larger sampling clock jitter generated by FPGA; and low sampling frequency introduces more noise to the receiver. Then the influence of sampling noise cannot be neglected. The paper analyzes the sampling noise, presents its influence on the carrier noise ratio, and derives the ranging error by calculating the synchronization error of the delay locked loop. Simulations aiming at each impact factors of sampling-noise-induced ranging error are performed. Simulation and experiment results show that if the target ranging accuracy is at the level of centimeter, the quantization length should be no less than 8 and the sampling clock jitter should not exceed 30ps.

  3. Analysis of referrals received by a psychiatric unit in a general hospital Part 2

    Directory of Open Access Journals (Sweden)

    VJ Ehlers


    Full Text Available The study sought to analyse the referrals received by a psychiatric unit in a general hospital in the Western Cape by studying the referral letters and the referral responses.

    Hierdie navorsing het gepoog om verwysings te ontleed wat deur 'n psigiatriese eenheid in 'n algemene hospitaal in die Wes Kaap ontvang is. *Please note: This is a reduced version of the abstract. Please refer to PDF for full text.

  4. Solar power satellite rectenna design study: Directional receiving elements and parallel-series combining analysis (United States)

    Gutmann, R. J.; Borrego, J. M.


    Rectenna conversion efficiencies (RF to dc) approximating 85 percent were demonstrated on a small scale, clearly indicating the feasibility and potential of efficiency of microwave power to dc. The overall cost estimates of the solar power satellite indicate that the baseline rectenna subsystem will be between 25 to 40 percent of the system cost. The directional receiving elements and element extensions were studied, along with power combining evaluation and evaluation extensions.

  5. Patient perspectives on care received at community acupuncture clinics: a qualitative thematic analysis



    Abstract Background Community acupuncture is a recent innovation in acupuncture service delivery in the U.S. that aims to improve access to care through low-cost treatments in group-based settings. Patients at community acupuncture clinics represent a broader socioeconomic spectrum and receive more frequent treatments compared to acupuncture users nationwide. As a relatively new model of acupuncture in the U.S., little is known about the experiences o...

  6. Pattern-matching analysis of fine echo delays by the spectrogram correlation and transformation receiver. (United States)

    Park, Munhum; Allen, Robert


    Among a few previous attempts to model the outstanding echolocation capability of bats, the work by Saillant et al. [J. Acoust. Soc. Am. 94, 2691-2712 (1993)] is, arguably, one of the most frequently referenced studies in which the predictions of spectrogram correlation and transformation (SCAT) model were compared to the results of relevant behavioral experiments. The SCAT model consists of cochlear, spectrogram correlation and spectrogram transformation blocks, where the latter two processes estimate the overall and the fine time delays between the animal's call and the echoes, given the neural representation of the acoustic signals generated by the cochlear block. This paper first provides a rigorous account of the spectrogram transformation (ST) block. By approximating the neural signals in analytic forms, many aspects of the ST block are explained and discussed in relation to the predictive scope of the model. Furthermore, based on these analytical arguments, the ST block is investigated from a different point of view, interpreted as a pattern-matching process which may operate at the high level of the animal's auditory pathway.

  7. Design of shielded encircling send-receive type pulsed eddy current probe using numerical analysis method

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Young Kil [Dept. of Electircal Engineeirng, Kunsan National University, Kunsan (Korea, Republic of)


    An encircling send-receive type pulsed eddy current (PEC) probe is designed for use in aluminum tube inspection. When bare receive coils located away from the exciter were used, the peak time of the signal did not change although the distance from the exciter increased. This is because the magnetic flux from the exciter coil directly affects the receive coil signal. Therefore, in this work, both the exciter and the sensor coils were shielded in order to reduce the influence of direct flux from the exciter coil. Numerical simulation with the designed shielded encircling PEC probe showed the corresponding increase of the peak time as the sensor distance increased. Ferrite and carbon steel shields were compared and results of the ferrite shielding showed a slightly stronger peak value and a quicker peak time than those of the carbon steel shielding. Simulation results showed that the peak value increased as the defect size (such as depth and length) increased regardless of the sensor location. To decide a proper sensor location, the sensitivity of the peak value to defect size variation was investigated and found that the normalized peak value was more sensitive to defect size variation when the sensor was located closer to the exciter.

  8. Optics characterization of a 900-GHz HEB receiver for the ASTE telescope: design, measurement and tolerance analysis (United States)

    Gonzalez, A.; Soma, T.; Shiino, T.; Kaneko, K.; Uzawa, Y.; Yamamoto, S.


    The optics of a 900-GHz HEB receiver for the ASTE telescope have been analyzed by quasi-optical analysis and Physical Optics simulations in combination with beam pattern measurements. The disagreement between simulations and measurements has motivated an extensive campaign of Monte Carlo analyses to find out the cause of such a difference in results. Monte Carlo analyses have considered fabrication and assembly tolerances in all components in the RF chain, as well as some non-expected fabrication errors. This strategy has allowed determining the defective component. In short, the use of all available analyses techniques together with measurements has allowed singling out an underperforming element in an astronomical receiver. The change of this component will improve the optical efficiency and ease astronomical observations. These ideas can be of interest for any quasi-optical receiver at THz frequencies.

  9. A New Homotopy Analysis Method for Approximating the Analytic Solution of KdV Equation

    Directory of Open Access Journals (Sweden)

    Vahid Barati


    Full Text Available In this study a new technique of the Homotopy Analysis Method (nHAM is applied to obtain an approximate analytic solution of the well-known Korteweg-de Vries (KdV equation. This method removes the extra terms and decreases the time taken in the original HAM by converting the KdV equation to a system of first order differential equations. The resulted nHAM solution at third order approximation is then compared with that of the exact soliton solution of the KdV equation and found to be in excellent agreement.

  10. Analytical modeling of the input admittance of an electric drive for stability analysis purposes (United States)

    Girinon, S.; Baumann, C.; Piquet, H.; Roux, N.


    Embedded electric HVDC distribution network are facing difficult issues on quality and stability concerns. In order to help to resolve those problems, this paper proposes to develop an analytical model of an electric drive. This self-contained model includes an inverter, its regulation loops and the PMSM. After comparing the model with its equivalent (abc) full model, the study focuses on frequency analysis. The association with an input filter helps in expressing stability of the whole assembly by means of Routh-Hurtwitz criterion.

  11. A Symbolic Formulation for Analytical Compliance Analysis and Synthesis of Flexure Mechanisms. (United States)

    Su, Hai-Jun; Shi, Hongliang; Yu, Jingjun


    This paper presents a symbolic formulation for analytical compliance analysis and synthesis of flexure mechanisms with serial, parallel, or hybrid topologies. Our approach is based on the screw theory that characterizes flexure deformations with motion twists and loadings with force wrenches. In this work, we first derive a symbolic formulation of the compliance and stiffness matrices for commonly used flexure elements, flexure joints, and simple chains. Elements of these matrices are all explicit functions of flexure parameters. To analyze a general flexure mechanism, we subdivide it into multiple structural modules, which we identify as serial, parallel, or hybrid chains. We then analyze each module with the known flexure structures in the library. At last, we use a bottom-up approach to obtain the compliance/stiffness matrix for the overall mechanism. This is done by taking appropriate coordinate transformation of twists and wrenches in space. Four practical examples are provided to demonstrate the approach. A numerical example is employed to compare analytical compliance models against a finite element model. The results show that the errors are sufficiently small (2%, compared with finite element (FE) model), if the range of motion is limited to linear deformations. This work provides a systematical approach for compliance analysis and synthesis of general flexure mechanisms. The symbolic formulation enables subsequent design tasks, such as compliance synthesis or sensitivity analysis.

  12. Analysis of 10B by PIGE with factor analytical gamma-ray peak identification. (United States)

    Savolainen, S; Räisänen, J; Eteläniemi, V; Abo Ramadan, U A; Kallio, M


    Studying the biodistribution of boronated compounds for B neutron capture therapy (BNCT) requires the accurate detection of low levels of boron (10B) in biological samples. Proton induced gamma-ray emission analysis (PIGE) of 10B was found to be viable in a study of low density lipoprotein (LDL), in tissue and blood samples. However, the method is sensitive to Na present in the samples and can therefore not be used for accurate measurements of 10B concentrations below 5 ppm in samples containing Na. PIGE can be considered to be an appropriate reference method for chemical B analysis. The factor analytical method presented here is the most objective way to separate Na and B peaks from each other, and the factorizing method can be applied in different forms of spectral analysis.

  13. Design and thermal analysis of a direct steam generation central-receiver solar thermal power plant


    Garrido Camino, Carlos


    Thermo-solar central receiver power plants use radiation coming from the Sun, a clean energy source, to produce electricity. The best locations for this type of installations are the ones between 30º and 40º of latitude, both in the northern and southern hemisphere, what makes Spain to be one of the most suitable and attractive places all over the world for this energy source. However, this technology is not well developed yet comparing to other renewable energy sources such as wind energy or...

  14. Application of Nomographs for Analysis and Prediction of Receiver Spurious Response EMI (United States)


    cud permit cLction of optiniuni test frequencies. The Technical )wO’tidu v prepareA frut a paper with the same title inserted at the VS 1.EE-E...TEST DIRECTORATE PATUXENT RIVER, MARYLAND 20670-5304 I I. CONTROLLING OFFICE NAME ANO ADDRESS 12. REPORT DATE NAVAL AIR TEST CENTER 23 JULY 1985...receiver interuodulotion Pit . and associated Da For W . Fit) (2) margins. o The INC ctst engineer takes a different perspective wheret Flo w Local

  15. Analysis, development and testing of a fixed tilt solar collector employing reversible Vee-Trough reflectors and vacuum tube receivers (United States)

    Selcuk, M. K.


    The Vee-Trough/Vacuum Tube Collector (VTVTC) aimed to improve the efficiency and reduce the cost of collectors assembled from evacuated tube receivers. The VTVTC was analyzed rigorously and a mathematical model was developed to calculate the optical performance of the vee-trough concentrator and the thermal performance of the evacuated tube receiver. A test bed was constructed to verify the mathematical analyses and compare reflectors made out of glass, Alzak and aluminized GEB Teflon. Tests were run at temperatures ranging from 95 to 180 C during the months of April, May, June, July and August 1977. Vee-trough collector efficiencies of 35-40 per cent were observed at an operating temperature of about 175 C. Test results compared well with the calculated values. Test data covering a complete day are presented for selected dates throughout the test season. Predicted daily useful heat collection and efficiency values are presented for a year's duration at operation temperatures ranging from 65 to 230 C. Estimated collector costs and resulting thermal energy costs are presented. Analytical and experimental results are discussed along with an economic evaluation.

  16. Exact capture probability analysis of GSC receivers over i.n.d. Rayleigh fading channels

    KAUST Repository

    Nam, Sungsik


    A closed-form expression of the capture probability of generalized selection combining (GSC) RAKE receivers was introduced in [1]. The idea behind this new performance metric is to quantify how the remaining set of uncombined paths affects the overall performance both in terms of loss in power and increase in interference levels. In this previous work, the assumption was made that the fading is both independent and identically distributed from path to path. However, the average strength of each path is different in reality. In order to derive a closed-form expression of the capture probability over independent and non-identically distributed (i.n.d.) fading channels, we need to derive the joint statistics of ordered non-identical exponential variates. With this motivation in mind, we first provide in this paper some new order statistics results in terms of both moment generating function (MGF) and probability density function (PDF) expressions under an i.n.d. assumption and then derive a new exact closed-form expression for the capture probability GSC RAKE receivers in this more realistic scenario. © 2013 IEEE.

  17. Crustal structure in the southern part of West Java based on analysis of teleseismic receiver function (United States)

    Syuhada, Anggono, Titi


    We analyzed teleseismic receiver functions from five broadband stations to determine the crustal thickness and Vp/vs ratios in the southern part of west Java. We observed that the study area is characterized by crustal thickness around 31-37 km with Vp/Vs varying between 1.66 and 1.87. We suggest that lower values of Vp/Vs obtained in some stations indicate more felsic crustal composition. The mid-crust low velocity zone is observed beneath a seismic station located near the volcanic zones with high values of Vp/Vs ratio suggesting the presence of partial melt due to geothermal activities in the upper mantle. Furthermore, a seismic station located near the active fault zone also has high Vp/Vs ratio, which may indicate the presence of fluid filled fracture zone. However, this station exhibits complicated receiver functions, thus it needs further research involving a larger dataset with good backazimuth coverage of the teleseismic data to resolve this issue.

  18. Accuracy Analysis of Position Estimation Based on Measurements of Received Signal Strength Difference

    Institute of Scientific and Technical Information of China (English)

    LIU Lin; FAN Ping-zhi


    The performance of a cellular location system based on received signal strength difference (RSSD) is investigated. In the cellular location system, each mobile station needs to measure the signal strength transmitted by surrounding base stations, and sends its measurements to the service base station. Using the strength differonce between the service base station and neighboring base stations, the position of a mobile station is estimated. The related Cramer-Rao lower bound (CRLB) on the location error of this method was derived, and numerical simulations are made to discuss the influences of the number of base stations, correlation coefficient of shadowing attenuation, and cell radius on CRLB. The results show that the CRLB is positively correlated with the standard deviation of shadowing attenuation and cell radius, but negatively correlated with the number of base stations and the correlation coefficient of shadowing attenuation. In addition, the CRLB results obtained in this paper were compared with those of the cellular location system based on received signal strength (RSS) measurements, which reveals that the former is more fight.

  19. Receiver Function Analysis of the Lithospheric Structure Beneath the Western Great Plains (United States)

    Thurner, S.; Zhai, Y.; Levander, A.


    The lithosphere in the western Great Plain region of the Southwestern U.S. has been subject to tectonic deformation from the Proterozoic to present day. Proterozoic island arc terranes accreted onto the North American continent between 1.8 and 1.1 Ga, forming the original continent, and there is evidence for Proterozoic continental extension which formed basement penetrating faults between 1.5 and .6 Ga . This was followed by the uplift of the Ancestral Rockies and, most recently, the subduction of the Farallon plate beneath North America. Extension has occurred throughout the Basin and Range and formed the Rio Grand Rift (RGR). However, the relative impact that large scale tectonic forces, regional asthenospheric upwelling, and preexisting structural weaknesses have on the extension of the RGR is still undetermined. This study seeks to better understand the current tectonic system east of the Colorado Plateau beneath the RGR and western Great Plains. We use teleseismic receiver functions to investigate the nature of extension in the RGR as well as its connection to the small-scale convection thought to be occurring beneath the Colorado Plateau-RGR-Great Plains region. Our receiver function images were generated from 85 earthquake events recorded at 187 USArray Transportable Array seismic stations located throughout the western Great Plains (Latitude: 28-48, Longitude: -105-100). Previous studies have indicated crustal thickness between 39 km and 50 km beneath the Great Plains and as thin as 35 km beneath the RGR (Wilson, 2005). Tomography results have shown high velocity anomalies on both sides of the RGR, extending to 600 km depth beneath the western Great Plains, and a low velocity anomaly directly beneath the RGR (Gok et. al, 2003, Wilson et. al, 2005, Gao et. al, Song and Helmberger, 2007). The western Great Plains high velocity anomaly has been interpreted to be part of the downwelling portion of an edge driven convection system induced by a lateral

  20. Analysis of the bureaucratic unsolicited mountainous paper heap (BUMPH) that general practitioners received in 1994. (United States)

    Kenny, D.


    OBJECTIVES--To record and analyse the bureaucratic unsolicited mountainous paper heap (BUMPH) received by general practitioners; to make some suggestions for coping with the ensuing workload. DESIGN--Daily record of all BUMPH landing on the desk of a general practitioner in one year. SETTING--Mixed practice with one full time and two job sharing principals. RESULTS--5100 pages of BUMPH arrived during the year. The most prolific source of origin was health authorities (1549 pages). Fridays, Mondays, and the day after a holiday were the days BUMPH was most frequently seen. CONCLUSIONS--BUMPH is a major source of workload. One way of avoiding it is not to work on the day after a day off. Images p1706-a PMID:8541768

  1. Analysis of heterogeneity in molecular weight and shape by analytical ultracentrifugation using parallel distributed computing. (United States)

    Demeler, Borries; Brookes, Emre; Nagel-Steger, Luitgard


    A computational approach for fitting sedimentation velocity experiments from an analytical ultracentrifuge in a model-independent fashion is presented. This chapter offers a recipe for obtaining high-resolution information for both the shape and the molecular weight distributions of complex mixtures that are heterogeneous in shape and molecular weight and provides suggestions for experimental design to optimize information content. A combination of three methods is used to find the solution most parsimonious in parameters and to verify the statistical confidence intervals of the determined parameters. A supercomputer implementation with a MySQL database back end is integrated into the UltraScan analysis software. The UltraScan LIMS Web portal is used to perform the calculations through a Web interface. The performance and limitations of the method when employed for the analysis of complex mixtures are demonstrated using both simulated data and experimental data characterizing amyloid aggregation.

  2. Costs of Quality: Exploratory Analysis of Hidden Elements and Prioritization using Analytic Hierarchy Process

    Directory of Open Access Journals (Sweden)

    Sailaja A


    Full Text Available Cost of Quality analysis is emerged as an effective tool for the industrial managers for pinpointing the deficiencies in the system as well as for identifying the improvement areas by highlighting the cost reduction opportunities. However , this analysis will be fully effective only if it is further extended to identify the cost incurred in ensuring quality in all areas of the supply chain including the hidden costs and costs of missed out opportunities. Most of the hidden elements of quality costs are difficult to track and not accounted by the traditional accounting tools. An exploratory analysis is made in this research to identify the hidden elements of quality costs in manufacturing industry. Further, the identified cost elements are classified into various groups for better analysis and, finally, prioritized to identify the vital few among them. Analytic Hierarchy Process (AHP technique which is one of the most popular Multi Criteria Decision Method (MCDM and Pareto analysis were used in this study for prioritizing the hidden quality cost elements based on their degree of impact on overall cost of quality. By this analysis, the key cost elements which are to be addressed to reduce the overall cost of quality are identified.

  3. Analytical modeling and thermodynamic analysis of robust superhydrophobic surfaces with inverse-trapezoidal microstructures. (United States)

    Im, Maesoon; Im, Hwon; Lee, Joo-Hyung; Yoon, Jun-Bo; Choi, Yang-Kyu


    A polydimethylsiloxane (PDMS) elastomer surface with perfectly ordered microstructures having an inverse-trapezoidal cross-sectional profile (simply PDMS trapezoids) showed superhydrophobic and transparent characteristics under visible light as reported in our previous work. The addition of a fluoropolymer (Teflon) coating enhances both features and provides oleophobicity. This paper focuses on the analytical modeling of the fabricated PDMS trapezoids structure and thermodynamic analysis based on the Gibbs free energy analysis. Additionally, the wetting characteristics of the fabricated PDMS trapezoids surface before and after the application of the Teflon coating are analytically explained. The Gibbs free energy analysis reveals that, due to the Teflon coating, the Cassie-Baxter state becomes energetically more favorable than the Wenzel state and the contact angle difference between the Cassie-Baxter state and the Wenzel state decreases. These two findings support the robustness of the superhydrophobicity of the fabricated Teflon-coated PDMS trapezoids. This is then verified via the impinging test of a water droplet at a high speed. The dependencies of the design parameters in the PDMS trapezoids on the hydrophobicity are also comprehensively studied through a thermodynamic analysis. Geometrical dependency on the hydrophobicity shows that overhang microstructures do not have a significant influence on the hydrophobicity. In contrast, the intrinsic contact angle of the structural material is most important in determining the apparent contact angle. On the other hand, the experimental results showed that the side angles of the overhangs are critical not for the hydrophobic but for the oleophobic property with liquids of a low surface tension. Understanding of design parameters in the PDMS trapezoids surface gives more information for implementation of superhydrophobic surfaces.

  4. Analytics for Education (United States)

    MacNeill, Sheila; Campbell, Lorna M.; Hawksey, Martin


    This article presents an overview of the development and use of analytics in the context of education. Using Buckingham Shum's three levels of analytics, the authors present a critical analysis of current developments in the domain of learning analytics, and contrast the potential value of analytics research and development with real world…

  5. Analysis for Resolution of Bistatic SAR Configuration with Geosynchronous Transmitter and UAV Receiver

    Directory of Open Access Journals (Sweden)

    Yicheng Jiang


    Full Text Available Bistatical SAR with geosynchronous illuminator and unmanned aerial vehicle receiver (GEO-UAV BiSAR has significant potential advantages in the field of continuous local observation under a dangerous environment within nearly 24 h. Due to the extreme platform velocity differences, the ellipse orbital movement of GEOSAR makes this BiSAR configuration not like the conventional spaceborne BiSAR. In this paper, based on the orbital kinetic characteristic of GEOSAR, we theoretically analyze the variations of bistatic configuration effect on common azimuth coverage and coherent accumulated time. In addition, two-dimension the resolution is deduced by geometrical configuration on the basis of gradient method. The simulations show that the appropriate selection of initial bistatic configuration can restrain from the appearance of the dead zone in common coverage. And the image results are obtained by frequency domain RD based on Method of Series Reversion (MSR. It is shown that GEO-UAV BiSAR has the high resolution ability.

  6. Crust and uppermost mantle structure of the Ailaoshan-Red River fault from receiver function analysis

    Institute of Scientific and Technical Information of China (English)

    XU; Mingjie; WANG; Liangshu; LIU; Jianhua; ZHONG; Kai; LI; Hua; HU; Dezhao; XU; Zhen


    S-wave velocity structure beneath the Ailaoshan-Red River fault was obtained from receiver functions by using teleseismic body wave records of broadband digital seismic stations. The average crustal thickness, Vp/Vs ratio and Poisson's ratio were also estimated. The results indicate that the interface of crust and mantle beneath the Ailaoshan-Red River fault is not a sharp velocity discontinuity but a characteristic transition zone. The velocity increases relatively fast at the depth of Moho and then increases slowly in the uppermost mantle. The average crustal thickness across the fault is 36-37 km on the southwest side and 40-42 km on the northeast side, indicating that the fault cuts the crust. The relatively high Poisson's ratio (0.26-0.28) of the crust implies a high content of mafic materials in the lower crust. Moreover, the lower crust with low velocity could be an ideal position for decoupling between the crust and upper mantle.

  7. An analytical method for error analysis of GRACE-like missions based on spectral analysis

    CERN Document Server

    Cai, Lin; Li, Qiong; Luo, Zhicai; Hsu, Houtse


    The aim of this paper is to present an analytical relationship between the power spectral density of GRACE-like mission measurements and the accuracies of the gravity field coefficients mainly from the point of view of theory of signal and system, which indicates the one-to-one correspondence between spherical harmonic error degree variances and frequencies of the measurement noise. In order to establish this relationship, the average power of the errors due to gravitational acceleration difference and the relationship between perturbing forces and range-rate perturbations are derived, based on the orthogonality property of associated Legendre functions and the linear orbit perturbation theory, respectively. This method provides a physical insight into the relation between mission parameters and scientific requirements. By taking GRACE-FO as the object of research, the effects of sensor noises and time variable gravity signals are analyzed. If LRI measurements are applied, a mission goal with a geoid accuracy...

  8. Topological data analysis: A promising big data exploration tool in biology, analytical chemistry and physical chemistry. (United States)

    Offroy, Marc; Duponchel, Ludovic


    An important feature of experimental science is that data of various kinds is being produced at an unprecedented rate. This is mainly due to the development of new instrumental concepts and experimental methodologies. It is also clear that the nature of acquired data is significantly different. Indeed in every areas of science, data take the form of always bigger tables, where all but a few of the columns (i.e. variables) turn out to be irrelevant to the questions of interest, and further that we do not necessary know which coordinates are the interesting ones. Big data in our lab of biology, analytical chemistry or physical chemistry is a future that might be closer than any of us suppose. It is in this sense that new tools have to be developed in order to explore and valorize such data sets. Topological data analysis (TDA) is one of these. It was developed recently by topologists who discovered that topological concept could be useful for data analysis. The main objective of this paper is to answer the question why topology is well suited for the analysis of big data set in many areas and even more efficient than conventional data analysis methods. Raman analysis of single bacteria should be providing a good opportunity to demonstrate the potential of TDA for the exploration of various spectroscopic data sets considering different experimental conditions (with high noise level, with/without spectral preprocessing, with wavelength shift, with different spectral resolution, with missing data).

  9. Granular Flow Dynamics on Earth, Moon, and Mars from analytical, numerical and field analysis (United States)

    Lucas, A.; Mangeney, A.; Mhge, D.


    Prediction of landslides dynamics remains difficult in spite of a considerable body of work. A number of previous studies have been based on runout analysis in relation to mean dissipation calibration via the friction coefficient. However, the shape of the initial scar is generally unknown in real cases, which weakens landslide material spreading predictions and has alters calibration parameters of numerical models. We study numerically the effects of scar geometry on flow and distribution of the deposits and show that the initial shape of the scar, independent of the friction coefficient, does not affect the runout distance. In contrast, 3D tests show that the shape of the final deposits is a function of the scar geometry, and hence information on initial scar geometry and initial volume involved in the mass spreading may be retrieved from analysis of final deposit morphology. From an analytical solution we show here why the classical mobility (defined as the ratio between total height and runout distance) decreases when the volume increases, as is generally observed in geological data. We thus introduce analytically a new mobility variable obtained from geomorphic measurements reflecting the intrinsic dissipation independent of the aspect ratio, of the volume of the granular mass involved, of the underlying topography, and of the initial scar geometry. Comparison between experimental results, terrestrial, Lunar and Martian cases highlights a larger new mobility measure of natural granular flows compared to dry mass spreading simulated in the laboratory. In addition, landslides in a similar geological context give a single value showing the robustness of this new parameter. Finally, the new mobility provides a first order estimate of the effective friction required in models to reproduce the extent of the deposits in a given geological context. This enables a feedback analysis method for retrieving the volume and shape of the initial landslide material and then

  10. An analysis of beam parameters on proton-acoustic waves through an analytic approach. (United States)

    Aytac Kipergil, Esra; Erkol, Hakan; Kaya, Serhat; Gulsen, Gultekin; Unlu, Mehmet


    It has been reported that acoustic waves are generated when a high energy pulsed proton beam is deposited in a small volume within tissue. One possible application of the proton induced acoustics is to get a real-time feedback for intratreatment adjustments by monitoring such acoustic waves. High spatial resolution in ultrasound imaging may reduce proton range uncertainty. Thus, it is crucial to understand the dependence of the acoustic waves on the proton beam characteristics. In this manuscript, firstly, an analytic solution to the proton induced acoustic wave is presented to reveal the dependence of signal on beam parameters, and then combined with an analytic approximation of the Bragg curve. The influence of the beam energy, pulse duration, and beam diameter variation on the acoustic waveform are investigated. Further analysis is performed regarding the Fourier decomposition of proton-acoustic signals. Our results show that smaller spill time of proton beam upsurges the amplitude of acoustic wave for constant number of protons, and hence beneficial for dose monitoring. The increase in the energy of each individual proton in the beam leads to spatial broadening of the Bragg curve, which also yields acoustic waves of greater amplitude. The pulse duration and the beam width of the proton beam do not affect the central frequency of the acoustic wave, but they change the amplitude of the spectral components.

  11. A non-linear analytic stress model for the analysis on the stress interaction between TSVs

    Directory of Open Access Journals (Sweden)

    Ming-Han Liao


    Full Text Available Thermo-elastic strain is induced by through silicon vias (TSV due to the difference of thermal expansion coefficients between the copper (∼18 ppm/◦C and silicon (∼2.8 ppm/◦C when the structure is exposed to a thermal budget in the three dimensional integrated circuit (3DIC process. These thermal expansion stresses are high enough to induce the delamination on the interfaces between the copper, silicon, and isolated dielectric. A compact analytic model for the strain field induced by different layouts of thermal copper filled TSVs with the linear superposition principle is found to result in large errors due to the strong stress interaction between TSVs. In this work, a nonlinear stress analytic model with different TSV layouts is demonstrated by the finite element method and Mohr’s circle analysis. The stress characteristics are also measured by the atomic force microscope-raman technique at a nanometer level resolution. This nonlinear stress model for the strong interactions between TSVs results in an electron mobility change ~2-6% smaller than that resulting from a model that only considers the linear stress superposition principle.

  12. Longitudinal analysis of quality of life in patients receiving conformal radiation therapy for prostate cancer

    Energy Technology Data Exchange (ETDEWEB)

    Geinitz, Hans; Thamm, Reinhard; Scholz, Christian; Heinrich, Christine; Prause, Nina; Kerndl, Simone; Molls, Michael; Zimmermann, Frank B. [Dept. of Radiotherapy and Radiooncology, Technische Univ. Muenchen (Germany); Keller, Monika [Psychooncology Section, Dept. of Psychosomatic and General Clinical Medicine, Univ. Hospital, Heidelberg (Germany); Busch, Raymonde [Inst. of Medical Statistics and Epidemiology, Technische Univ. Muenchen (Germany)


    Purpose: To prospectively assess quality of life (QoL) in patients receiving conformal radiation therapy (CRT) for prostate cancer. Patients and Methods: 78 men with definitive CRT for prostate cancer were entered into the study. Patients were assessed before CRT, at 40 and 60 Gy, and 2, 12 and 24 months after the end of treatment. QoL was assessed using the EORTC Quality of Life Questionnaire C30 and the prostate module PR25. Changes in mean QoL scores with time of {>=} 10 points were considered clinically relevant. Results: Global QoL did not change statistically significant during CRT and was slightly above baseline levels during follow-up. CRT had a statistically significant negative short-term impact on role functioning, fatigue, and PR25 urinary symptoms. The scores recovered within 2 months to 1 year after CRT. Emotional functioning and social functioning scores slightly increased during and after CRT. Role functioning decreased by > 10 points at 60 Gy and urinary symptoms decreased by > 10 points at 40 and 60 Gy. All other differences were < 10 points. A high number of concomitant diseases and having no children were negative pretreatment predictors for long-term global QoL. Conclusion: Definitive CRT for prostate cancer does not compromise global QoL during therapy and up to 2 years after treatment. It has a limited negative effect on role functioning, urinary symptoms and, to a lesser extent, on fatigue with restitution within 2 months to 1 year after treatment. (orig.)

  13. Low Complexity Precoder and Receiver Design for Massive MIMO Systems: A Large System Analysis using Random Matrix Theory

    KAUST Repository

    Sifaou, Houssem


    Massive MIMO systems are shown to be a promising technology for next generations of wireless communication networks. The realization of the attractive merits promised by massive MIMO systems requires advanced linear precoding and receiving techniques in order to mitigate the interference in downlink and uplink transmissions. This work considers the precoder and receiver design in massive MIMO systems. We first consider the design of the linear precoder and receiver that maximize the minimum signal-to-interference-plus-noise ratio (SINR) subject to a given power constraint. The analysis is carried out under the asymptotic regime in which the number of the BS antennas and that of the users grow large with a bounded ratio. This allows us to leverage tools from random matrix theory in order to approximate the parameters of the optimal linear precoder and receiver by their deterministic approximations. Such a result is of valuable practical interest, as it provides a handier way to implement the optimal precoder and receiver. To reduce further the complexity, we propose to apply the truncated polynomial expansion (TPE) concept on a per-user basis to approximate the inverse of large matrices that appear on the expressions of the optimal linear transceivers. Using tools from random matrix theory, we determine deterministic approximations of the SINR and the transmit power in the asymptotic regime. Then, the optimal per-user weight coe cients that solve the max-min SINR problem are derived. The simulation results show that the proposed precoder and receiver provide very close to optimal performance while reducing signi cantly the computational complexity. As a second part of this work, the TPE technique in a per-user basis is applied to the optimal linear precoding that minimizes the transmit power while satisfying a set of target SINR constraints. Due to the emerging research eld of green cellular networks, such a problem is receiving increasing interest nowadays. Closed

  14. Effects of aerobic exercise on cancer-related fatigue in breast cancer patients receiving chemotherapy: a meta-analysis. (United States)

    Zou, Ling-Yun; Yang, Liu; He, Xiao-Ling; Sun, Ming; Xu, Jin-Jiang


    Increasing scientific evidences suggest that aerobic exercise may improve cancer-related fatigue in breast cancer patients, but many existing studies have yielded inconclusive results. This meta-analysis aimed to derive a more precise estimation of the effects of aerobic exercise on cancer-related fatigue in breast cancer patients receiving chemotherapy. The PubMed, CISCOM, CINAHL, Web of Science, Google Scholar, EBSCO, Cochrane Library, and CBM databases were searched from inception through July 1, 2013 without language restrictions. Crude standardized mean difference (SMD) with 95 % confidence interval (CI) was calculated. Twelve comparative studies were assessed with a total of 1,014 breast cancer patients receiving chemotherapy, including 522 patients in the aerobic exercise group (intervention group) and 492 patients in the usual care group (control group). The meta-analysis results revealed that the Revised Piper Fatigue Scale (RPFS) scores of breast cancer patients in the intervention group were significantly lower than those in the control group (SMD=-0.82, 95% CI=-1.04 ∼ -0.60, Pintervention and control groups (SMD=0.09, 95% CI=-0.07 ∼ 0.25, P=0.224). Subgroup analysis by ethnicity indicated that there were significant differences in RPFS and FACIT-F scores between the intervention and control groups among Asian populations (RPFS: SMD=-1.08, 95% CI=-1.35 ∼ -0.82, P0.05). The current meta-analysis indicates that aerobic exercise may improve cancer-related fatigue in breast cancer patients receiving chemotherapy, especially among Asian populations.

  15. Pure-rotational spectrometry: a vintage analytical method applied to modern breath analysis. (United States)

    Hrubesh, Lawrence W; Droege, Michael W


    Pure-rotational spectrometry (PRS) is an established method, typically used to study structures and properties of polar gas-phase molecules, including isotopic and isomeric varieties. PRS has also been used as an analytical tool where it is particularly well suited for detecting or monitoring low-molecular-weight species that are found in exhaled breath. PRS is principally notable for its ultra-high spectral resolution which leads to exceptional specificity to identify molecular compounds in complex mixtures. Recent developments using carbon aerogel for pre-concentrating polar molecules from air samples have extended the sensitivity of PRS into the part-per-billion range. In this paper we describe the principles of PRS and show how it may be configured in several different modes for breath analysis. We discuss the pre-concentration concept and demonstrate its use with the PRS analyzer for alcohols and ammonia sampled directly from the breath.

  16. Improving analytic hierarchy process applied to fire risk analysis of public building

    Institute of Scientific and Technical Information of China (English)

    SHI Long; ZHANG RuiFang; XIE QiYuan; FU LiHua


    The structure importance in Fault Tree Analysis (FTA) reflects how important Basic Events are to Top Event.Attribute at alternative level in Analytic Hierarchy Process (AHP) also reflect its importance to general goal.Based on the coherence of these two methods,an improved AHP is put forward.Using this improved method,how important the attribute is to the fire safety of public building can be ana-lyzed more credibly because of the reduction of subjective judgment.Olympic venues are very impor-tant public buildings in China.The fire safety evaluation of them will be a big issue to engineers.Im-proved AHP is a useful tool to the safety evaluation to these Olympic venues,and it will guide the evaluation in other areas.

  17. A semi-analytical method for the analysis of pile-supported embankments

    Institute of Scientific and Technical Information of China (English)

    Wan-huan ZHOU; Ren-peng CHEN; Lin-shuang ZHAO; Zheng-zhong XU; Yun-min CHEN


    In this paper,a semi-analytical method for the analysis of pile-supported embankments is proposed.The mathematic model describes the cooperative behavior of pile,pile cap,foundation soil,and embankment fills.Based on Terzaghi's ID consolidation theory of saturated soil,the consolidation of foundation soil is calculated.The embankments with two different types of piles:floating piles and end-bearing piles are investigated and discussed.The results of axial force and skin friction distributions along the pile and the settlements of pile-supported embankments are presented.It is found that it takes a longer time for soil consolidation in the embankment with floating piles,compared with the case using end-bearing piles.The differential settlement between the pile and surrounding soil at the pile top is larger for the embankment with end-bearing piles,compared with the case of floating piles.

  18. A Highly Accurate and Efficient Analytical Approach to Bridge Deck Free Vibration Analysis

    Directory of Open Access Journals (Sweden)

    D.J. Gorman


    Full Text Available The superposition method is employed to obtain an accurate analytical type solution for the free vibration frequencies and mode shapes of multi-span bridge decks. Free edge conditions are imposed on the long edges running in the direction of the deck. Inter-span support is of the simple (knife-edge type. The analysis is valid regardless of the number of spans or their individual lengths. Exact agreement is found when computed results are compared with known eigenvalues for bridge decks with all spans of equal length. Mode shapes and eigenvalues are presented for typical bridge decks of three and four span lengths. In each case torsional and non-torsional modes are studied.

  19. Some analytical approximations to radiative transfer theory and their application for the analysis of reflectance data (United States)

    Kokhanovsky, Alexander; Hopkinson, Ian


    We derive an analytical approximation in the framework of the radiative transfer theory for use in the analysis of diffuse reflectance measurements. This model uses two parameters to describe a material, the transport free path length, l, and the similarity parameter, s. Using a simple algebraic expression, s and l can be applied for the determination of the absorption coefficient Kabs, which can be easily compared to absorption coefficients measured using transmission spectroscopy. l and Kabs can be seen as equivalent to the S and K parameters, respectively, in the Kubelka-Munk formulation. The advantage of our approximation is a clear basis in the complete radiative transfer theory. We demonstrate the application of our model to a range of different paper types and to fabrics treated with known levels of a dye.

  20. Energy Efficiency Evaluation Based on Data Envelopment Analysis Integrated Analytic Hierarchy Process in Ethylene Production☆

    Institute of Scientific and Technical Information of China (English)

    Yongming Han; Zhiqiang Geng; Qiyu Liu


    Energy efficiency data from ethylene production equipment are of high dimension, dynamic and time sequential, so their evaluation is af ected by many factors. Abnormal data from ethylene production are eliminated through consisten-cy test, making the data consumption uniform to improve the comparability of data. Due to the limit of input and output data of decision making unit in data envelopment analysis (DEA), the energy efficiency data from the same technology in a certain year are disposed monthly using DEA. The DEA data of energy efficiency from the same technology are weighted and fused using analytic hierarchy process. The energy efficiency data from different technologies are evalu-ated by their relative ef ectiveness to find the direction of energy saving and consumption reduction.

  1. Regime transition in electromechanical fluid atomization and implications to analyte ionization for mass spectrometric analysis. (United States)

    Forbes, Thomas P; Degertekin, F Levent; Fedorov, Andrei G


    The physical processes governing the transition from purely mechanical ejection to electromechanical ejection to electrospraying are investigated through complementary scaling analysis and optical visualization. Experimental characterization and visualization are performed with the ultrasonically-driven array of micromachined ultrasonic electrospray (AMUSE) ion source to decouple the electrical and mechanical fields. A new dimensionless parameter, the Fenn number, is introduced to define a transition between the spray regimes, in terms of its dependence on the characteristic Strouhal number for the ejection process. A fundamental relationship between the Fenn and Strouhal numbers is theoretically derived and confirmed experimentally in spraying liquid electrolytes of different ionic strength subjected to a varying magnitude electric field. This relationship and the basic understanding of the charged droplet generation physics have direct implications on the optimal ionization efficiency and mass spectrometric response for different types of analytes.

  2. 2D analysis of polydisperse core-shell nanoparticles using analytical ultracentrifugation. (United States)

    Walter, Johannes; Gorbet, Gary; Akdas, Tugce; Segets, Doris; Demeler, Borries; Peukert, Wolfgang


    Accurate knowledge of the size, density and composition of nanoparticles (NPs) is of major importance for their applications. In this work the hydrodynamic characterization of polydisperse core-shell NPs by means of analytical ultracentrifugation (AUC) is addressed. AUC is one of the most accurate techniques for the characterization of NPs in the liquid phase because it can resolve particle size distributions (PSDs) with unrivaled resolution and detail. Small NPs have to be considered as core-shell systems when dispersed in a liquid since a solvation layer and a stabilizer shell will significantly contribute to the particle's hydrodynamic diameter and effective density. AUC measures the sedimentation and diffusion transport of the analytes, which are affected by the core-shell compositional properties. This work demonstrates that polydisperse and thus widely distributed NPs pose significant challenges for current state-of-the-art data evaluation methods. The existing methods either have insufficient resolution or do not correctly reproduce the core-shell properties. First, we investigate the performance of different data evaluation models by means of simulated data. Then, we propose a new methodology to address the core-shell properties of NPs. This method is based on the parametrically constrained spectrum analysis and offers complete access to the size and effective density of polydisperse NPs. Our study is complemented using experimental data derived for ZnO and CuInS2 NPs, which do not have a monodisperse PSD. For the first time, the size and effective density of such structures could be resolved with high resolution by means of a two-dimensional AUC analysis approach.

  3. Value of the free light chain analysis in the clinical evaluation of response in multiple myeloma patients receiving anti-myeloma therapy

    DEFF Research Database (Denmark)

    Toftmann Hansen, Charlotte; Pedersen, Per T.; Jensen, Bo Amdi;

    Value of the free light chain analysis in the clinical evaluation of response in multiple myeloma patients receiving anti-myeloma therapy.......Value of the free light chain analysis in the clinical evaluation of response in multiple myeloma patients receiving anti-myeloma therapy....

  4. Familiarity Vs Trust: A Comparative Study of Domain Scientists' Trust in Visual Analytics and Conventional Analysis Methods. (United States)

    Dasgupta, Aritra; Lee, Joon-Yong; Wilson, Ryan; Lafrance, Robert A; Cramer, Nick; Cook, Kristin; Payne, Samuel


    Combining interactive visualization with automated analytical methods like statistics and data mining facilitates data-driven discovery. These visual analytic methods are beginning to be instantiated within mixed-initiative systems, where humans and machines collaboratively influence evidence-gathering and decision-making. But an open research question is that, when domain experts analyze their data, can they completely trust the outputs and operations on the machine-side? Visualization potentially leads to a transparent analysis process, but do domain experts always trust what they see? To address these questions, we present results from the design and evaluation of a mixed-initiative, visual analytics system for biologists, focusing on analyzing the relationships between familiarity of an analysis medium and domain experts' trust. We propose a trust-augmented design of the visual analytics system, that explicitly takes into account domain-specific tasks, conventions, and preferences. For evaluating the system, we present the results of a controlled user study with 34 biologists where we compare the variation of the level of trust across conventional and visual analytic mediums and explore the influence of familiarity and task complexity on trust. We find that despite being unfamiliar with a visual analytic medium, scientists seem to have an average level of trust that is comparable with the same in conventional analysis medium. In fact, for complex sense-making tasks, we find that the visual analytic system is able to inspire greater trust than other mediums. We summarize the implications of our findings with directions for future research on trustworthiness of visual analytic systems.


    Institute of Scientific and Technical Information of China (English)

    杨维; 程时昕


    The conventional 2D-Rake receivers for code-division multiple access (CDMA) system over frequency-selective fading channels are generally based on the second-order statistics while assuming perfect array conditions. However, the sensor response, location uncertainty, and the use of sample statistics can severely degrade the performance of second-order statistics processing. And in practical application, it is impossible to calibrate the array frequently. In this paper a cumulant-based 2D-Rake receiver for synchronous CDMA system with decorrelator is presented. Decorrelating is a multi-user detection approach that not only provides a fundamental solution to the mutual interference problem in CDMA communications but also makes it convenient for the decoupled signal to be processed spatially and temporally. High-order signal processing has some inherent advantages over that of second-order. Employing second-order statistics it is impossible to estimate source steering vector blindly, while employing higher than second-order cumulants, this purpose can be achieved. The performance analysis shows that employing cumulant-based signal processing technique the proposed 2D-Rake receiver is blind and demonstrates excellent performance.

  6. Incorporating the nuclear vibrational energies into the -atom in molecules- analysis: An analytical study

    CERN Document Server

    Gharabaghi, Masumeh


    The orthodox quantum theory of atoms in molecules (QTAIM) is based on the clamped nucleus paradigm and working solely with the electronic wavefunctions, so unable to include nuclear vibrations in the AIM analysis. On the other hand, the recently extended version of the QTAIM, called the multi-component QTAIM (MC-QTAIM), incorporates both electrons and quantum nuclei, i.e. those nuclei treated as quantum waves instead of clamped point charges, into the AIM analysis using non-adiabatic wavefunctions. Thus, the MC-QTAIM is the natural framework to incorporate the role of nuclear vibrations into the AIM analysis. In this study, within the context of the MC-QTAIM, the formalism of including nuclear vibrational energy in the atomic basin energy is developed in detail and its contribution is derived analytically using the recently proposed non-adiabatic Hartree product nuclear wavefunction. It is demonstrated that within the context of this wavefunction the quantum nuclei may be conceived pseudo-adiabatically as qua...

  7. Analysis of Local Control in Patients Receiving IMRT for Resected Pancreatic Cancers

    Energy Technology Data Exchange (ETDEWEB)

    Yovino, Susannah; Maidment, Bert W. [Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD (United States); Herman, Joseph M. [Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD (United States); Pandya, Naimish; Goloubeva, Olga [Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD (United States); Wolfgang, Chris; Schulick, Richard; Laheru, Daniel [Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD (United States); Hanna, Nader; Alexander, Richard [Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD (United States); Regine, William F., E-mail: [Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD (United States)


    Purpose: Intensity-modulated radiotherapy (IMRT) is increasingly incorporated into therapy for pancreatic cancer. A concern regarding this technique is the potential for geographic miss and decreased local control. We analyzed patterns of first failure among patients treated with IMRT for resected pancreatic cancer. Methods and Materials: Seventy-one patients who underwent resection and adjuvant chemoradiation for pancreas cancer are included in this report. IMRT was used for all to a median dose of 50.4 Gy. Concurrent chemotherapy was 5-FU-based in 72% of patients and gemcitabine-based in 28%. Results: At median follow-up of 24 months, 49/71 patients (69%) had failed. The predominant failure pattern was distant metastases in 35/71 patients (49%). The most common site of metastases was the liver. Fourteen patients (19%) developed locoregional failure in the tumor bed alone in 5 patients, regional nodes in 4 patients, and concurrently with metastases in 5 patients. Median overall survival (OS) was 25 months. On univariate analysis, nodal status, margin status, postoperative CA 19-9 level, and weight loss during treatment were predictive for OS. On multivariate analysis, higher postoperative CA19-9 levels predicted for worse OS on a continuous basis (p < 0.01). A trend to worse OS was seen among patients with more weight loss during therapy (p = 0.06). Patients with positive nodes and positive margins also had significantly worse OS (HR for death 2.8, 95% CI 1.1-7.5; HR for death 2.6, 95% CI 1.1-6.2, respectively). Grade 3-4 nausea and vomiting was seen in 8% of patients. Late complication of small bowel obstruction occurred in 4 (6%) patients. Conclusions: This is the first comprehensive report of patterns of failure among patients treated with adjuvant IMRT for pancreas cancer. IMRT was not associated with an increase in local recurrences in our cohort. These data support the use of IMRT in the recently activated EORTC/US Intergroup/RTOG 0848 adjuvant pancreas


    Directory of Open Access Journals (Sweden)

    Irina Petrova


    Full Text Available The research deals with the issue of the patent analysis efficiency, which is a necessary stage of seaching analogues and prototypes to obtain technical solutions. The article presents the results of analyzing the present automation systems for finding necessary information in the patent databases and identifies their advantages and disadvantages. It gives a description of the “Intellect” system, which is an example of software systems for the conceptual design stage support. Materials and Methods The article presents some of the possible ways to organize the patents-analogues search process and specific features of searching analogues and prototypes for the generated parametric structure scheme of the technical solution, which is the result of the synthesis of a new information-measuring and control system element in the “Intellect” system. The description of the proposed search query forming method is given. The article gives the structure of the patent passport, which must be stored in a database to organize the process of searcing analogues and prototypes. There given a description of algorithms for automatic adding a patent to the database, recalculating the weights while adding a patent by experts, identifying the fact of using different physical and technical effects in a patent. Results The final part of the article contains an example of the results of testing the developed subsystem implementing the proposed method. According to the test results it is concluded that the selected software and algorithmic solutions are effective.

  9. Trends in the analytical methods for water analysis; Tendencias de los metodos analiticos para el analisis del agua

    Energy Technology Data Exchange (ETDEWEB)

    Tortajada-Genero, L. A.; Campins-Falco, P. [Universidad de Valencia (Spain)


    The technological and methodological advances have provided and evolution of analytical chemistry, specially in the area of water analysis. There area wide variety of problems for this kind of analysis, as result of the high number of possible objectives. They involve from complex environmental studies to routine control of a physical-chemical parameter. Additionally, the variety of analysis to analyse is increasing as in total number as in complexity terms. The response has been the appearance of a high number of analytical methods. Some guidelines and recommendations have been described together with different strategies for quality assurance. In this paper, a review of the last analytical methods described in the scientific references for determinations in water was realised. The evolution and future perspectives were also studied. (Author) 16 refs.

  10. Web analytics tools and web metrics tools: An overview and comparative analysis


    Ivan Bekavac; Daniela Garbin Praničević


    The aim of the paper is to compare and analyze the impact of web analytics tools for measuring the performance of a business model. Accordingly, an overview of web analytics and web metrics tools is given, including their characteristics, main functionalities and available types. The data acquisition approaches and proper choice of web tools for particular business models are also reviewed. The research is divided in two sections. First, a qualitative focus is placed on reviewing web analytic...

  11. Using Landscape Metrics Analysis and Analytic Hierarchy Process to Assess Water Harvesting Potential Sites in Jordan

    Directory of Open Access Journals (Sweden)

    Abeer Albalawneh


    Full Text Available Jordan is characterized as a “water scarce” country. Therefore, conserving ecosystem services such as water regulation and soil retention is challenging. In Jordan, rainwater harvesting has been adapted to meet those challenges. However, the spatial composition and configuration features of a target landscape are rarely considered when selecting a rainwater-harvesting site. This study aimed to introduce landscape spatial features into the schemes for selecting a proper water-harvesting site. Landscape metrics analysis was used to quantify 10 metrics for three potential landscapes (i.e., Watershed 104 (WS 104, Watershed 59 (WS 59, and Watershed 108 (WS 108 located in the Jordanian Badia region. Results of the metrics analysis showed that the three non–vegetative land cover types in the three landscapes were highly suitable for serving as rainwater harvesting sites. Furthermore, Analytic Hierarchy Process (AHP was used to prioritize the fitness of the three target sites by comparing their landscape metrics. Results of AHP indicate that the non-vegetative land cover in the WS 104 landscape was the most suitable site for rainwater harvesting intervention, based on its dominance, connectivity, shape, and low degree of fragmentation. Our study advances the water harvesting network design by considering its landscape spatial pattern.

  12. Amendment to "Performance Analysis of the V-BLAST Algorithm: An Analytical Approach." [1

    CERN Document Server

    Loyka, Sergey


    An analytical technique for the outage and BER analysis of the nx2 V-BLAST algorithm with the optimal ordering has been presented in [1], including closed-form exact expressions for average BER and outage probabilities, and simple high-SNR approximations. The analysis in [1] is based on the following essential approximations: 1. The SNR was defined in terms of total after-projection signal and noise powers, and the BER was analyzed based on their ratio. This corresponds to a non-coherent (power-wise) equal-gain combining of both the signal and the noise, and it is not optimum since it does not provide the maximum output SNR. 2. The definition of the total after-projection noise power at each step ignored the fact that the after-projection noise vector had correlated components. 3. The after-combining noises at different steps (and hence the errors) were implicitly assumed to be independent of each other. Under non-coherent equal-gain combining, that is not the case. It turns out that the results in [1] hold a...

  13. Automatic evaluation and data generation for analytical chemistry instrumental analysis exercises

    Directory of Open Access Journals (Sweden)

    Arsenio Muñoz de la Peña


    Full Text Available In general, laboratory activities are costly in terms of time, space, and money. As such, the ability to provide realistically simulated laboratory data that enables students to practice data analysis techniques as a complementary activity would be expected to reduce these costs while opening up very interesting possibilities. In the present work, a novel methodology is presented for design of analytical chemistry instrumental analysis exercises that can be automatically personalized for each student and the results evaluated immediately. The proposed system provides each student with a different set of experimental data generated randomly while satisfying a set of constraints, rather than using data obtained from actual laboratory work. This allows the instructor to provide students with a set of practical problems to complement their regular laboratory work along with the corresponding feedback provided by the system's automatic evaluation process. To this end, the Goodle Grading Management System (GMS, an innovative web-based educational tool for automating the collection and assessment of practical exercises for engineering and scientific courses, was developed. The proposed methodology takes full advantage of the Goodle GMS fusion code architecture. The design of a particular exercise is provided ad hoc by the instructor and requires basic Matlab knowledge. The system has been employed with satisfactory results in several university courses. To demonstrate the automatic evaluation process, three exercises are presented in detail. The first exercise involves a linear regression analysis of data and the calculation of the quality parameters of an instrumental analysis method. The second and third exercises address two different comparison tests, a comparison test of the mean and a t-paired test.

  14. Video Analytics

    DEFF Research Database (Denmark)

    include: re-identification, consumer behavior analysis, utilizing pupillary response for task difficulty measurement, logo detection, saliency prediction, classification of facial expressions, face recognition, face verification, age estimation, super-resolution, pose estimation, and pain recognition......This book collects the papers presented at two workshops during the 23rd International Conference on Pattern Recognition (ICPR): the Third Workshop on Video Analytics for Audience Measurement (VAAM) and the Second International Workshop on Face and Facial Expression Recognition (FFER) from Real...

  15. An Analytical Model for the Performance Analysis of Concurrent Transmission in IEEE 802.15.4

    Directory of Open Access Journals (Sweden)

    Cengiz Gezer


    Full Text Available Interference is a serious cause of performance degradation for IEEE802.15.4 devices. The effect of concurrent transmissions in IEEE 802.15.4 has been generally investigated by means of simulation or experimental activities. In this paper, a mathematical framework for the derivation of chip, symbol and packet error probability of a typical IEEE 802.15.4 receiver in the presence of interference is proposed. Both non-coherent and coherent demodulation schemes are considered by our model under the assumption of the absence of thermal noise. Simulation results are also added to assess the validity of the mathematical framework when the effect of thermal noise cannot be neglected. Numerical results show that the proposed analysis is in agreement with the measurement results on the literature under realistic working conditions.

  16. An Analytical Model for the Performance Analysis of Concurrent Transmission in IEEE 802.15.4 (United States)

    Gezer, Cengiz; Zanella, Alberto; Verdone, Roberto


    Interference is a serious cause of performance degradation for IEEE802.15.4 devices. The effect of concurrent transmissions in IEEE 802.15.4 has been generally investigated by means of simulation or experimental activities. In this paper, a mathematical framework for the derivation of chip, symbol and packet error probability of a typical IEEE 802.15.4 receiver in the presence of interference is proposed. Both non-coherent and coherent demodulation schemes are considered by our model under the assumption of the absence of thermal noise. Simulation results are also added to assess the validity of the mathematical framework when the effect of thermal noise cannot be neglected. Numerical results show that the proposed analysis is in agreement with the measurement results on the literature under realistic working conditions. PMID:24658624

  17. An analytical model for the performance analysis of concurrent transmission in IEEE 802.15.4. (United States)

    Gezer, Cengiz; Zanella, Alberto; Verdone, Roberto


    Interference is a serious cause of performance degradation for IEEE802.15.4 devices. The effect of concurrent transmissions in IEEE 802.15.4 has been generally investigated by means of simulation or experimental activities. In this paper, a mathematical framework for the derivation of chip, symbol and packet error probability of a typical IEEE 802.15.4 receiver in the presence of interference is proposed. Both non-coherent and coherent demodulation schemes are considered by our model under the assumption of the absence of thermal noise. Simulation results are also added to assess the validity of the mathematical framework when the effect of thermal noise cannot be neglected. Numerical results show that the proposed analysis is in agreement with the measurement results on the literature under realistic working conditions.

  18. The Promise and Peril of Predictive Analytics in Higher Education: A Landscape Analysis (United States)

    Ekowo, Manuela; Palmer, Iris


    Predictive analytics in higher education is a hot-button topic among educators and administrators as institutions strive to better serve students by becoming more data-informed. In this paper, the authors describe how predictive analytics are used in higher education to identify students who need extra support, steer students in courses they will…

  19. The Role of Teamwork in the Analysis of Big Data: A Study of Visual Analytics and Box Office Prediction. (United States)

    Buchanan, Verica; Lu, Yafeng; McNeese, Nathan; Steptoe, Michael; Maciejewski, Ross; Cooke, Nancy


    Historically, domains such as business intelligence would require a single analyst to engage with data, develop a model, answer operational questions, and predict future behaviors. However, as the problems and domains become more complex, organizations are employing teams of analysts to explore and model data to generate knowledge. Furthermore, given the rapid increase in data collection, organizations are struggling to develop practices for intelligence analysis in the era of big data. Currently, a variety of machine learning and data mining techniques are available to model data and to generate insights and predictions, and developments in the field of visual analytics have focused on how to effectively link data mining algorithms with interactive visuals to enable analysts to explore, understand, and interact with data and data models. Although studies have explored the role of single analysts in the visual analytics pipeline, little work has explored the role of teamwork and visual analytics in the analysis of big data. In this article, we present an experiment integrating statistical models, visual analytics techniques, and user experiments to study the role of teamwork in predictive analytics. We frame our experiment around the analysis of social media data for box office prediction problems and compare the prediction performance of teams, groups, and individuals. Our results indicate that a team's performance is mediated by the team's characteristics such as openness of individual members to others' positions and the type of planning that goes into the team's analysis. These findings have important implications for how organizations should create teams in order to make effective use of information from their analytic models.

  20. Original position statistic distribution analysis (original position analysis)--A new analytical method in research and quality evaluation of materials

    Institute of Scientific and Technical Information of China (English)



    Original position statistic distribution analysis (OPA) is a new analytical method to determine the quantitative distribution of different chemical compositions and their states on a big scope of the materials. A new quantitative metal original position analyzer, which was invented based on the analysis technology of single discharge analysis (SDA) and a continuous scanning excitement spark spectrum without pre-excitement, can be used effectively to analyze the original position statistic distribution of the metals. Thus, the new information of the materials, such as the quantitative statistic distribution of contents of various elements and inclusions on different positions in the materials, the distribution of the size of the inclusions, can be obtained. The technique can also be applied to the accurate calculation of the segregation of various elements in the materials, as well as the quantitative description of the homogeneity and porosity of the materials. The concept of the original position statistic distribution analysis along with the wide utilization of the metal original position analyzer will provide researchers and scientists a new method to study the inside characteristics and properties of the materials.

  1. A Novel WPT System Based on Dual Transmitters and Dual Receivers for High Power Applications: Analysis, Design and Implementation

    Directory of Open Access Journals (Sweden)

    Yong Li


    Full Text Available Traditional Wireless Power Transfer (WPT systems only have one energy transmission path, which can hardly meet the power demand for high power applications, e.g., railway applications (electric trains and trams, etc. due to the capacity constraints of power electronic devices. A novel WPT system based on dual transmitters and dual receivers is proposed in this paper to upgrade the power capacity of the WPT system. The reliability and availability of the proposed WPT system can be dramatically improved due to the four energy transmission paths. A three-dimensional finite element analysis (FEA tool ANSYS MAXWELL (ANSYS, Canonsburg, PA, USA is adopted to investigate the proposed magnetic coupling structure. Besides, the effects of the crossing coupling mutual inductances among the transmitters and receivers are analyzed. It shows that the same-side cross couplings will decrease the efficiency and transmitted power. Decoupling transformers are employed to mitigate the effects of the same-side cross couplings. Meanwhile, the output voltage in the secondary side can be regulated at its designed value with a fast response performance, and the system can continue work even with a faulty inverter. Finally, a scale-down experimental setup is provided to verify the proposed approach. The experimental results indicate that the proposed method could improve the transmitted power capacity, overall efficiency and reliability, simultaneously. The proposed WPT structure is a potential alternative for high power applications.

  2. Network Traffic Analysis With Query Driven VisualizationSC 2005HPC Analytics Results

    Energy Technology Data Exchange (ETDEWEB)

    Stockinger, Kurt; Wu, Kesheng; Campbell, Scott; Lau, Stephen; Fisk, Mike; Gavrilov, Eugene; Kent, Alex; Davis, Christopher E.; Olinger,Rick; Young, Rob; Prewett, Jim; Weber, Paul; Caudell, Thomas P.; Bethel,E. Wes; Smith, Steve


    Our analytics challenge is to identify, characterize, and visualize anomalous subsets of large collections of network connection data. We use a combination of HPC resources, advanced algorithms, and visualization techniques. To effectively and efficiently identify the salient portions of the data, we rely on a multi-stage workflow that includes data acquisition, summarization (feature extraction), novelty detection, and classification. Once these subsets of interest have been identified and automatically characterized, we use a state-of-the-art-high-dimensional query system to extract data subsets for interactive visualization. Our approach is equally useful for other large-data analysis problems where it is more practical to identify interesting subsets of the data for visualization than to render all data elements. By reducing the size of the rendering workload, we enable highly interactive and useful visualizations. As a result of this work we were able to analyze six months worth of data interactively with response times two orders of magnitude shorter than with conventional methods.

  3. Structural damage localization by outlier analysis of signal-processed mode shapes - Analytical and experimental validation (United States)

    Ulriksen, M. D.; Damkilde, L.


    Contrary to global modal parameters such as eigenfrequencies, mode shapes inherently provide structural information on a local level. Therefore, this particular modal parameter and its derivatives are utilized extensively for damage identification. Typically, more or less advanced mathematical methods are employed to identify damage-induced discontinuities in the spatial mode shape signals, hereby, potentially, facilitating damage detection and/or localization. However, by being based on distinguishing damage-induced discontinuities from other signal irregularities, an intrinsic deficiency in these methods is the high sensitivity towards measurement noise. In the present paper, a damage localization method which, compared to the conventional mode shape-based methods, has greatly enhanced robustness towards measurement noise is proposed. The method is based on signal processing of a spatial mode shape by means of continuous wavelet transformation (CWT) and subsequent application of a generalized discrete Teager-Kaiser energy operator (GDTKEO) to identify damage-induced mode shape discontinuities. In order to evaluate whether the identified discontinuities are in fact damage-induced, outlier analysis is conducted by applying the Mahalanobis metric to major principal scores of the sensor-located bands of the signal-processed mode shape. The method is tested analytically and benchmarked with other mode shape-based damage localization approaches on the basis of a free-vibrating beam and validated experimentally in the context of a residential-sized wind turbine blade subjected to an impulse load.

  4. Analytical model and stability analysis of the leading edge spar of a passively morphing ornithopter wing. (United States)

    Wissa, Aimy; Calogero, Joseph; Wereley, Norman; Hubbard, James E; Frecker, Mary


    This paper presents the stability analysis of the leading edge spar of a flapping wing unmanned air vehicle with a compliant spine inserted in it. The compliant spine is a mechanism that was designed to be flexible during the upstroke and stiff during the downstroke. Inserting a variable stiffness mechanism into the leading edge spar affects its structural stability. The model for the spar-spine system was formulated in terms of the well-known Mathieu's equation, in which the compliant spine was modeled as a torsional spring with a sinusoidal stiffness function. Experimental data was used to validate the model and results show agreement within 11%. The structural stability of the leading edge spar-spine system was determined analytically and graphically using a phase plane plot and Strutt diagrams. Lastly, a torsional viscous damper was added to the leading edge spar-spine model to investigate the effect of damping on stability. Results show that for the un-damped case, the leading edge spar-spine response was stable and bounded; however, there were areas of instability that appear for a range of spine upstroke and downstroke stiffnesses. Results also show that there exist a damping ratio between 0.2 and 0.5, for which the leading edge spar-spine system was stable for all values of spine upstroke and downstroke stiffnesses.

  5. Improved analytic extreme-mass-ratio inspiral model for scoping out eLISA data analysis

    CERN Document Server

    Chua, Alvin J K


    The space-based gravitational-wave detector eLISA has been selected as the ESA L3 mission, and the mission design will be finalised by the end of this decade. To prepare for mission formulation over the next few years, several outstanding and urgent questions in data analysis will be addressed using mock data challenges, informed by instrument measurements from the LISA Pathfinder satellite launching at the end of 2015. These data challenges will require accurate and computationally affordable waveform models for anticipated sources such as the extreme-mass-ratio inspirals (EMRIs) of stellar-mass compact objects into massive black holes. Previous data challenges have made use of the well-known analytic EMRI waveforms of Barack and Cutler, which are extremely quick to generate but dephase relative to more accurate waveforms within hours, due to their mismatched radial, polar and azimuthal frequencies. In this paper, we describe an augmented Barack-Cutler model that uses a frequency map to the correct Kerr freq...

  6. Elasto-plastic strain analysis by a semi-analytical method

    Indian Academy of Sciences (India)

    Debabrata Das; Prasanta Sahoo; Kashinath Saha


    The aim of this paper is to develop a simulation model of large deformation problems following a semi-analytical method, incorporating the complications of geometric and material non-linearity in the formulation. The solution algorithm is based on the method of energy principle in structural mechanics, as applicable for conservative systems. A one-dimensional solid circular bar problem has been solved in post-elastic range assuming linear elastic, linear strain hardening material behaviour. Type of loading includes uniform uniaxial loading and gravity loading due to body force, whereas the geometry of the bar is considered to be non-uniformly taper. Results are validated successfully with benchmark solution and some new results have also been reported. The location of initiation of elasto-plastic front and its growth are found to be functions of geometry of the bar and loading conditions. Some indicative results have been presented for static and dynamic problems and the solution methodology developed for one-dimension has been extended to the elasto-plastic analysis of two-dimensional strain field problems of a rotating disk.

  7. Solid waste facilities location using of analytical network process and data envelopment analysis approaches. (United States)

    Khadivi, M R; Fatemi Ghomi, S M T


    Selection of the appropriate site for solid waste facilities is a complex problem and requires an extensive evaluation process, because it is very difficult to develop a selection criterion that can precisely describe the preference of one location over another. Therefore selection of these sites can be viewed as a multiple criteria decision-making or multiple attributes decision-making problem. For this purpose, we propose a technique that can effectively take managerial preferences and subjective data into consideration, along with quantitative factors. The tool proposed here relies on the use of the analytical network process (ANP) and to help integrate managerial evaluations into a more quantitatively based decision tool, data envelopment analysis (DEA) is applied. In this paper, a location selection procedure is presented to construct an undesirable facility applying ANP and DEA approaches in two stages. In the first stage ANP approach is used, results of this stage are inputs for the second stage. In this stage, DEA is applied to select the best location. Finally, to illustrate the proposed framework, at "Results and discussion" section, a total of four undesirable facility locations are evaluated.

  8. Analytic Multi-Regge Theory and the Pomeron in QCD; 2, Gauge Theory Analysis

    CERN Document Server

    White, Alan R


    The high-energy Regge behavior of gauge theories is studied via the formalism of Analytic Multi-Regge Theory. Perturbative results for spontaneously-broken theories are first organised into reggeon diagrams. Unbroken gauge theories are studied via a reggeon diagram infra-red analysis of symmetry restoration. Massless fermions play a crucial role and the case of QCD involves the Super-Critical Pomeron as an essential intermediate stage. An introductory review of the build up of transverse momentum diagrams and reggeon diagrams from leading log calculations in gauge theories is presented first. It is then shown that the results closely reproduce the general structure for multi-regge amplitudes derived in Part I of the article, allowing the construction of general reggeon diagrams for spontaneously-broken theories. Next it is argued that, with a transverse-momentum cut-off, unbroken gauge theories can be reached through an infra-red limiting process which successively decouples fundamental representation Higgs f...

  9. GeneAnalytics Pathway Analysis and Genetic Overlap among Autism Spectrum Disorder, Bipolar Disorder and Schizophrenia

    Directory of Open Access Journals (Sweden)

    Naveen S. Khanzada


    Full Text Available Bipolar disorder (BPD and schizophrenia (SCH show similar neuropsychiatric behavioral disturbances, including impaired social interaction and communication, seen in autism spectrum disorder (ASD with multiple overlapping genetic and environmental influences implicated in risk and course of illness. GeneAnalytics software was used for pathway analysis and genetic profiling to characterize common susceptibility genes obtained from published lists for ASD (792 genes, BPD (290 genes and SCH (560 genes. Rank scores were derived from the number and nature of overlapping genes, gene-disease association, tissue specificity and gene functions subdivided into categories (e.g., diseases, tissues or functional pathways. Twenty-three genes were common to all three disorders and mapped to nine biological Superpathways including Circadian entrainment (10 genes, score = 37.0, Amphetamine addiction (five genes, score = 24.2, and Sudden infant death syndrome (six genes, score = 24.1. Brain tissues included the medulla oblongata (11 genes, score = 2.1, thalamus (10 genes, score = 2.0 and hypothalamus (nine genes, score = 2.0 with six common genes (BDNF, DRD2, CHRNA7, HTR2A, SLC6A3, and TPH2. Overlapping genes impacted dopamine and serotonin homeostasis and signal transduction pathways, impacting mood, behavior and physical activity level. Converging effects on pathways governing circadian rhythms support a core etiological relationship between neuropsychiatric illnesses and sleep disruption with hypoxia and central brain stem dysfunction.

  10. Characterization of plutonium-bearing wastes by chemical analysis and analytical electron microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Behrens, R.G. [Los Alamos National Lab., NM (United States); Buck, E.C.; Dietz, N.L.; Bates, J.K.; Van Deventer, E.; Chaiko, D.J. [Argonne National Lab., IL (United States)


    This report summarizes the results of characterization studies of plutonium-bearing wastes produced at the US Department of Energy weapons production facilities. Several different solid wastes were characterized, including incinerator ash and ash heels from Rocky Flats Plant and Los Alamos National Laboratory; sand, stag, and crucible waste from Hanford; and LECO crucibles from the Savannah River Site. These materials were characterized by chemical analysis and analytical electron microscopy. The results showed the presence of discrete PuO{sub 2}PuO{sub 2{minus}x}, and Pu{sub 4}O{sub 7} phases, of about 1{mu}m or less in size, in all of the samples examined. In addition, a number of amorphous phases were present that contained plutonium. In all the ash and ash heel samples examined, plutonium phases were found that were completely surrounded by silicate matrices. Consequently, to achieve optimum plutonium recovery in any chemical extraction process, extraction would have to be coupled with ultrafine grinding to average particle sizes of less than 1 {mu}m to liberate the plutonium from the surrounding inert matrix.

  11. Advanced organic analysis and analytical methods development: FY 1995 progress report. Waste Tank Organic Safety Program

    Energy Technology Data Exchange (ETDEWEB)

    Wahl, K.L.; Campbell, J.A.; Clauss, S.A. [and others


    This report describes the work performed during FY 1995 by Pacific Northwest Laboratory in developing and optimizing analysis techniques for identifying organics present in Hanford waste tanks. The main focus was to provide a means for rapidly obtaining the most useful information concerning the organics present in tank waste, with minimal sample handling and with minimal waste generation. One major focus has been to optimize analytical methods for organic speciation. Select methods, such as atmospheric pressure chemical ionization mass spectrometry and matrix-assisted laser desorption/ionization mass spectrometry, were developed to increase the speciation capabilities, while minimizing sample handling. A capillary electrophoresis method was developed to improve separation capabilities while minimizing additional waste generation. In addition, considerable emphasis has been placed on developing a rapid screening tool, based on Raman and infrared spectroscopy, for determining organic functional group content when complete organic speciation is not required. This capability would allow for a cost-effective means to screen the waste tanks to identify tanks that require more specialized and complete organic speciation to determine tank safety.

  12. Analytic hierarchy process analysis for choosing a corporate social entrepreneurship strategy

    Directory of Open Access Journals (Sweden)

    Hadad Shahrazad


    Full Text Available After conducting an extensive analysis of both the specialised literature and practice and identifying three types of corporate social entrepreneurship in my PhD thesis titled “Corporate social entrepreneurship - the new paradigm of reshaping and rethinking business”, I decided to determine which of the three approaches is mostly suited for the Romanian market. The three types of corporate social entrepreneurship: corporate social entrepreneurship as local development tool, corporate social entrepreneurship as market development tool, and corporate social entrepreneurship as transformational innovation tool were organised as the alternatives of a carefully constructed hierarchy having as criteria: return on investment (which does not necessarily refer to the money that the company invests in the strategy; the term is derived from sustainability and scalability, degree of novelty, pre-entry knowledge and interest in solving the communities’ social problems. The questionnaire constructed based on the hierarchy using analytic hierarchy processes was distributed to experts (business developers coming from the following industries or sectors: beverages, IT, banking, furniture, and automotive. The research reveals which is the approach most likely to be employed by Romanian business developers. The results may be inferred to the sum of businesses represented by the expert business developers who were part of the research.

  13. A Big Data Analytics Pipeline for the Analysis of TESS Full Frame Images (United States)

    Wampler-Doty, Matthew; Pierce Doty, John


    We present a novel method for producing a catalogue of extra-solar planets and transients using the full frame image data from TESS. Our method involves (1) creating a fast Monte Carlo simulation of the TESS science instruments, (2) using the simulation to create a labeled dataset consisting of exoplanets with various orbital durations as well as transients (such as tidal disruption events), (3) using supervised machine learning to find optimal matched filters, Support Vector Machines (SVMs) and statistical classifiers (i.e. naïve Bayes and Markov Random Fields) to detect astronomical objects of interest and (4) “Big Data” analysis to produce a catalogue based on the TESS data. We will apply the resulting methods to all stars in the full frame images. We hope that by providing libraries that conform to industry standards of Free Open Source Software we may invite researchers from the astronomical community as well as the wider data-analytics community to contribute to our effort.

  14. A comparison of analytic hierarchy process and conjoint analysis methods in assessing treatment alternatives for stroke rehabilitation

    NARCIS (Netherlands)

    IJzerman, M.J.; Til, van J.A.; Bridges, J.F.P.


    Background: With growing emphasis on patient involvement in health technology assessment, there is a need for scientific methods that formally elicit patient preferences. Analytic hierarchy process (AHP) and conjoint analysis (CA) are two established scientific methods – albeit with very different o

  15. A Systematic Mapping on the Learning Analytics Field and Its Analysis in the Massive Open Online Courses Context (United States)

    Moissa, Barbara; Gasparini, Isabela; Kemczinski, Avanilde


    Learning Analytics (LA) is a field that aims to optimize learning through the study of dynamical processes occurring in the students' context. It covers the measurement, collection, analysis and reporting of data about students and their contexts. This study aims at surveying existing research on LA to identify approaches, topics, and needs for…

  16. moocRP: Enabling Open Learning Analytics with an Open Source Platform for Data Distribution, Analysis, and Visualization (United States)

    Pardos, Zachary A.; Whyte, Anthony; Kao, Kevin


    In this paper, we address issues of transparency, modularity, and privacy with the introduction of an open source, web-based data repository and analysis tool tailored to the Massive Open Online Course community. The tool integrates data request/authorization and distribution workflow features as well as provides a simple analytics module upload…

  17. An analytical solution of the Fokker-Planck equation in the phase-locked loop transient analysis (United States)

    Zhang, Weijian


    A probabilistic approach is used to obtain an analytical solution to the Fokker-Planck equation used in the transient analysis of the phase-locked loop phase error process of the first-order phase-locked loop. The solution procedure, which is based on the Girsanov transformation, is described.

  18. Receiver-Operating-Characteristic Analysis Reveals Superiority of Scale-Dependent Wavelet and Spectral Measures for Assessing Cardiac Dysfunction

    CERN Document Server

    Thurner, S; Lowen, S B; Teich, M C; Thurner, Stefan; Feurstein, Markus C.; Lowen, Steven B.; Teich, Malvin C.


    Receiver-operating-characteristic (ROC) analysis was used to assess the suitability of various heart rate variability (HRV) measures for correctly classifying electrocardiogram records of varying lengths as normal or revealing the presence of heart failure. Scale-dependent HRV measures were found to be substantially superior to scale-independent measures (scaling exponents) for discriminating the two classes of data over a broad range of record lengths. The wavelet-coefficient standard deviation at a scale near 32 heartbeat intervals, and its spectral counterpart near 1/32 cycles per interval, provide reliable results using record lengths just minutes long. A jittered integrate-and-fire model built around a fractal Gaussian-noise kernel provides a realistic, though not perfect, simulation of heartbeat sequences.

  19. Web analytics tools and web metrics tools: An overview and comparative analysis

    Directory of Open Access Journals (Sweden)

    Ivan Bekavac


    Full Text Available The aim of the paper is to compare and analyze the impact of web analytics tools for measuring the performance of a business model. Accordingly, an overview of web analytics and web metrics tools is given, including their characteristics, main functionalities and available types. The data acquisition approaches and proper choice of web tools for particular business models are also reviewed. The research is divided in two sections. First, a qualitative focus is placed on reviewing web analytics tools to exploring their functionalities and ability to be integrated into the respective business model. Web analytics tools support the business analyst’s efforts in obtaining useful and relevant insights into market dynamics. Thus, generally speaking, selecting a web analytics and web metrics tool should be based on an investigative approach, not a random decision. The second section is a quantitative focus shifting from theory to an empirical approach, and which subsequently presents output data resulting from a study based on perceived user satisfaction of web analytics tools. The empirical study was carried out on employees from 200 Croatian firms from either an either IT or marketing branch. The paper contributes to highlighting the support for management that available web analytics and web metrics tools available on the market have to offer, and based on the growing needs of understanding and predicting global market trends.

  20. Integrated Data Collection Analysis (IDCA) Program — KClO3 (as received)/Icing Sugar

    Energy Technology Data Exchange (ETDEWEB)

    Sandstrom, Mary M. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Brown, Geoffrey W. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Preston, Daniel N. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Pollard, Colin J. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Warner, Kirstin F. [Naval Surface Warfare Center (NSWC IHD), Indian Head, MD (United States). Indian Head Division; Sorenson, Daniel N. [Naval Surface Warfare Center (NSWC IHD), Indian Head, MD (United States). Indian Head Division; Remmers, Daniel L. [Naval Surface Warfare Center (NSWC IHD), Indian Head, MD (United States). Indian Head Division; Shelley, Timothy J. [Air Force Research Lab. (AFRL/RXQL), Tyndall AFB, FL (United States); Reyes, Jose A. [Applied Research Associates, Inc., Tyndall AFB, FL (United States); Hsu, Peter C. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Whipple, Richard E. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Reynolds, John G. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)


    The Integrated Data Collection Analysis (IDCA) program is conducting a proficiency study for Small-Scale Safety and Thermal (SSST) testing of homemade explosives (HMEs). Described here are the results for impact, friction, electrostatic discharge, and differential scanning calorimetry analysis of a mixture of KClO3 as received from the manufacturer mixed with icing sugar, sized through a 100-mesh sieve—KClO3/icing sugar (AR) mixture. This material was selected because of the challenge of performing SSST testing of a mixture of two solid materials. The mixture was found to: 1) be more sensitive to impact than RDX, similar to PETN, 2) be the same or less sensitive to friction than PETN, and 3) to be less sensitive to spark than RDX. The thermal analysis showed that the mixture has thermally stability similar to RDX and is perhaps more energetic upon decomposition but variable results indicate sampling issues. Compared to the 100-mesh sieved counter part, the KClO3/icing sugar (-100) mixture, the AR mixture was found to be about the same sensitivity towards impact, friction and ESD.

  1. An Analytical Approach for Analysis of Slider Bearings with Non-Newtonian Lubricants

    Directory of Open Access Journals (Sweden)

    Li-Ming Chu


    Full Text Available In this study, a regular perturbation technique is utilized to derive the modified Reynolds equation which is applicable to power-law lubricant. The performance of slider bearings including pressure distributions, velocity distributions, film thickness, load capacity, flow rate, shear force, and friction coefficient is also derived analytically for various ξ, flow indices (n, and outlet film thicknesses (H0. These analytical solutions are clear to find the effects of the operation parameters rather than numerical methods. It can be simply and fast used for engineers. Subsequently, these proposed analytical solutions are used to analyze the lubrication performance of slider bearing with the power-law fluids.

  2. Analytical Analysis and Case Study of Transient Behavior of Inrush Current in Power Transformer for Designing of Efficient Circuit Breakers (United States)

    Harmanpreet, Singh, Sukhwinder; Kumar, Ashok; Kaur, Parneet


    Stability & security are main aspects in electrical power systems. Transformer protection is major issue of concern to system operation. There are many mall-trip cases of transformer protection are caused by inrush current problems. The phenomenon of transformer inrush current has been discussed in many papers since 1958. In this paper analytical analysis of inrush current in a transformer switched on dc and ac supply has been done. This analysis will help in design aspects of circuit breakers for better performance.

  3. Clustering in analytical chemistry. (United States)

    Drab, Klaudia; Daszykowski, Michal


    Data clustering plays an important role in the exploratory analysis of analytical data, and the use of clustering methods has been acknowledged in different fields of science. In this paper, principles of data clustering are presented with a direct focus on clustering of analytical data. The role of the clustering process in the analytical workflow is underlined, and its potential impact on the analytical workflow is emphasized.

  4. Analytical and Experimental Modal Analysis for Operational Validation and Calibration of a Miniature Silicon Sensor (United States)

    Zhang, P. Q.; Tang, X. L.; Shan, B. X.; Brandon, J. A.; Kwan, A. S. K.


    The development of micromechanical sensors poses new challenges in design, calibration and operation. The paper reports a study where analytical and experimental techniques are applied to a prototype sensor. Analytically, a substructuring method is used together with a proprietary finite element package. Experimentally, novel excitation and response transducers are used to provide input data for specialised time domain identification algorithms. The resulting comparisons provide confidence in the combination of techniques used in the study.

  5. Summary receiver operating characteristics (SROC) and hierarchical SROC models for analysis of diagnostic test evaluations of antibody ELISAs for paratuberculosis. (United States)

    Toft, Nils; Nielsen, Søren S


    Critical, systematic reviews of available diagnostic test evaluations are a meticulous approach to synthesize evidence about a diagnostic test. However, often the review finds that data quality is poor due to deficiencies in design and reporting of the test evaluations and formal statistical comparisons are discouraged. Even when only simple summary measures are appropriate, the strong correlation between sensitivity and specificity and their dependence on differences in diagnostic threshold across studies, creates the need for tools to summarise properties of the diagnostic test under investigation. This study presents summary receiver operating characteristics (SROC) analysis as a means to synthesize information from diagnostic test evaluation studies. Using data from a review of diagnostic tests for ante mortem diagnosis of paratuberculosis as an illustration, SROC and hierarchical SROC (HSROC) analysis were used to estimate overall diagnostic accuracies of antibody ELISAs for bovine paratuberculosis while accounting for covariates: the target condition (infectious or infected) used in the test evaluation (one for the evaluation of Se and one for Sp); and the type of test (serum vs. milk). The methods gave comparable results (regarding the estimated diagnostic log odds ratio), considering the small sample size and the quality of data. The SROC analysis found a difference in the performance of tests when the target condition for evaluation of Se was infected rather than infectious, suggesting that ELISAs are not suitable for detecting infected cattle. However, the SROC model does not take differences in sample size between study units into account, whereas the HSROC allows for both between and within study variation. Considering the small sample size, more credibility should be given to the results of the HSROC. For both methods the area under the (H)SROC curve was calculated and results were comparable. The conclusion is that while the SROC is simpler and easier

  6. Diagnostic accuracy of serum biochemical fibrosis markers in children with chronic hepatitis B evaluated by receiver operating characteristics analysis

    Institute of Scientific and Technical Information of China (English)

    Dariusz Marek Lebensztejn; El(z)bieta Skiba; Jolanta Tobolczyk; Maria El(z)bieta Sobaniec-Lotowska; Maciej Kaczmarski


    AIM: To investigate the diagnostic accuracy of potent serum biochemical fibrosis markers in children with chronic hepatitis B evaluated by receiver operating characteristics (ROC) analysis.METHODS: We determined the serum level of apolipoprotein A-I (APO A-I), haptoglobin (HPT) and a-2macroglobulin (A2M) with an automatic nephelometer in 63 children (age range 4-17 years, mean 10 years)with biopsy-verified chronic HBeAg-positive hepatitis B.Fibrosis stage and inflammation grade were assessed in a blinded fashion according to Batts and Ludwig. We defined mild liver fibrosis as a score ≤2 and advanced fibrosis as a score equal to 3. ROC analysis was used to calculate the power of the assays to detect advanced liver fibrosis (AccuROC, Canada).RESULTS: Serum concentrations of APO A-I, HPT and A2M were not significantly different in patients with chronic hepatitis B compared to controls. However, APO A-I level of 1.19 ng/L had a sensitivity of 85.7% and a specificity of 60.7% (AUC = 0.7117, P = 0.035) to predict advanced fibrosis. All other serum biochemical markers and their combination did not allow a useful prediction.None of these markers was a good predictor of histologic inflammation.CONCLUSION: Apolipoprotein A-I may be a suitable serum marker to predict advanced liver fibrosis in children with chronic hepatitis B.

  7. Safety analysis, 200 Area, Savannah River Plant: Separations area operations. Receiving Basin for Offsite Fuel (Supplement 3)

    Energy Technology Data Exchange (ETDEWEB)

    Allen, P M


    Analysis of the Savannah River Plant RBOF and RRF included an evaluation of the reliability of process equipment and controls, administrative controls, and engineered safety features. The evaluation also identified potential scenarios and radiological consequences. Risks were calculated in terms of 50-year population dose commitment per year (man-rem/year) to the onsite and offsite population within an 80 Km radius of RBOF and RRF, and to an individual at the plant boundary. The total 50-year onsite and offsite population radiological risks of operating the RBOF and RRF were estimated to be 1.0 man-rem/year. These risks are significantly less than the population dose of 54,000 man/rem/yr for natural background radiation in a 50-mile radius. The 50-year maximum offsite individual risk from operating the facility was estimated to be 2.1 {times} 10{sup 5} rem/yr. These risks are significantly lower than 93 mrem/yr an individual is expected to receive from natural background radiation in this area. The analysis shows. that the RBOF and RRF can be operated without undue risk to onsite personnel or to the general public.

  8. Investigation of Lab Fire Prevention Management System of Combining Root Cause Analysis and Analytic Hierarchy Process with Event Tree Analysis

    Directory of Open Access Journals (Sweden)

    Cheng-Chan Shih


    Full Text Available This paper proposed a new approach, combining root cause analysis (RCA, analytic hierarchy process (AHP, and event tree analysis (ETA in a loop to systematically evaluate various laboratory safety prevention strategies. First, 139 fire accidents were reviewed to identify the root causes and draw out prevention strategies. Most fires were caused due to runaway reactions, operation error and equipment failure, and flammable material release. These mostly occurred in working places of no prompt fire protection. We also used AHP to evaluate the priority of these strategies and found that chemical fire prevention strategy is the most important control element, and strengthening maintenance and safety inspection intensity is the most important action. Also together with our surveys results, we proposed that equipment design is also critical for fire prevention. Therefore a technical improvement was propounded: installing fire detector, automatic sprinkler, and manual extinguisher in the lab hood as proactive fire protections. ETA was then used as a tool to evaluate laboratory fire risks. The results indicated that the total risk of a fire occurring decreases from 0.0351 to 0.0042 without/with equipment taking actions. Establishing such system can make Environment, Health and Safety (EH&S office not only analyze and prioritize fire prevention policies more practically, but also demonstrate how effective protective equipment improvement can achieve and the probabilities of the initiating event developing into a serious accident or controlled by the existing safety system.

  9. Analysis of Synthetic Cannabinoids in Botanical Material: A Review of Analytical Methods and Findings. (United States)

    Presley, B C; Jansen-Varnum, S A; Logan, B K


    Synthetic cannabinoid analogs have gained a great deal of attention from the forensic community within the last four years. The compounds found to be of most interest to forensic practitioners include those of the following series: JWH, CP, HU, AM, WIN, RCS, and most recently, XLR and UR. Structurally the HU compounds are most similar in structure to Δ9-tetrahydrocannabinol (THC), the main psychoactive component of marijuana. The novel compounds include cyclohexylphenols, naphthoylindoles, naphthylmethylindoles, naphthylmethylindenes, benzoylindoles, naphthoylpyrroles, phenylacetylindoles, adamantoylindoles, and tetramethylcyclopropylindoles. Many of these compounds are cannabinoid receptor agonists and were originally synthesized for medical research purposes but have recently been appropriated into the illicit drug market. Their psychoactive effects, mimicking those of marijuana, as well as their indeterminate legal status, have made them popular for recreational use. Solutions of the compounds dissolved in organic solvents are sprayed onto botanical material and sold as "herbal incense" products via the Internet, and in smoke shops, convenience stores, and gas stations around the world. Many of the products are labeled "Not for human consumption" in an attempt to circumvent legislation that bans the sale and manufacture of certain compounds and their analogs for human use. The compounds that were first detected following forensic analysis of botanical materials included JWH-018, JWH-073, and CP 47,497 (C7 and C8 homologs). However, in the four years since their appearance the number of compounds has grown, and additional diverse classes of compounds have been detected. Governments worldwide have taken action in an attempt to control those compounds that have become widespread in their regions. This article discusses the history of synthetic cannabinoids and how they have been detected in the illicit drug market. It also discusses the analytical methods and

  10. A two-dimensional analytical-model-based comparative threshold performance analysis of SOI-SON MOSFETs

    Institute of Scientific and Technical Information of China (English)

    Sanjoy Deb; Saptarsi Ghosh; N Basanta Singh; A K De; Subir Kumar Sarkar


    A generalized threshold voltage model based on two-dimensional Poisson analysis has been developed for SOI/SON MOSFETs.Different short channel field effects,such as fringing fields,junction-induced lateral fields and substrate fields,are carefully investigated,and the related drain-induced barrier-lowering effects are incorporated in the analytical threshold voltage model.Through analytical model-based simulation,the threshold voltage roll-off and subthreshold slope for both structures are compared for different operational and structural parameter variations.Results of analytical simulation are compared with the results of the ATLAS 2D physicsbased simulator for verification of the analytical model.The performance of an SON MOSFET is found to be significantly different from a conventional SOI MOSFET.The short channel effects are found to be reduced in an SON,thereby resulting in a lower threshold voltage roll-offand a smaller subthreshold slope.This type of analysis is quite useful to figure out the performance improvement of SON over SOI structures for next generation short channel MOS devices.

  11. Decentral gene expression analysis: analytical validation of the Endopredict genomic multianalyte breast cancer prognosis test

    Directory of Open Access Journals (Sweden)

    Kronenwett Ralf


    Full Text Available Abstract Background EndoPredict (EP is a clinically validated multianalyte gene expression test to predict distant metastasis in ER-positive, HER2-negative breast cancer treated with endocrine therapy alone. The test is based on the combined analysis of 12 genes in formalin-fixed, paraffin-embedded (FFPE tissue by reverse transcription-quantitative real-time PCR (RT-qPCR. Recently, it was shown that EP is feasible for reliable decentralized assessment of gene expression. The aim of this study was the analytical validation of the performance characteristics of the assay and its verification in a molecular-pathological routine laboratory. Methods Gene expression values to calculate the EP score were assayed by one-step RT-qPCR using RNA from FFPE tumor tissue. Limit of blank, limit of detection, linear range, and PCR efficiency were assessed for each of the 12 PCR assays using serial samples dilutions. Different breast cancer samples were used to evaluate RNA input range, precision and inter-laboratory variability. Results PCR assays were linear up to Cq values between 35.1 and 37.2. Amplification efficiencies ranged from 75% to 101%. The RNA input range without considerable change of the EP score was between 0.16 and 18.5 ng/μl. Analysis of precision (variation of day, day time, instrument, operator, reagent lots resulted in a total noise (standard deviation of 0.16 EP score units on a scale from 0 to 15. The major part of the total noise (SD 0.14 was caused by the replicate-to-replicate noise of the PCR assays (repeatability and was not associated with different operating conditions (reproducibility. Performance characteristics established in the manufacturer’s laboratory were verified in a routine molecular pathology laboratory. Comparison of 10 tumor samples analyzed in two different laboratories showed a Pearson coefficient of 0.995 and a mean deviation of 0.15 score units. Conclusions The EP test showed reproducible performance


    Institute of Scientific and Technical Information of China (English)

    Zhongwei SI; Jinyuan DU


    Let R0,n be the real Clifford algebra generated by e1,e2,…,en satisfying eiej +ejei =-2δij,i,j =1,2,…,n.e0 is the unit element.Let Ω be an open set.A function f is called left generalized analytic in Ω if f satisfies the equation Lf =0,(0.1)where L =q0e0(δ)x0 + q1e1(δ)x1 + … +qnen(δ)xn,qi > 0,i =0,1,…,n.In this article,we first give the kernel function.for the generalized analytic function.Further,the Hilbert boundary value problem for generalized analytic functions in Rn+1+ will be investigated.

  13. Analytic estimation of statistical significance maps for support vector machine based multi-variate image analysis and classification. (United States)

    Gaonkar, Bilwaj; Davatzikos, Christos


    Multivariate pattern analysis (MVPA) methods such as support vector machines (SVMs) have been increasingly applied to fMRI and sMRI analyses, enabling the detection of distinctive imaging patterns. However, identifying brain regions that significantly contribute to the classification/group separation requires computationally expensive permutation testing. In this paper we show that the results of SVM-permutation testing can be analytically approximated. This approximation leads to more than a thousandfold speedup of the permutation testing procedure, thereby rendering it feasible to perform such tests on standard computers. The speedup achieved makes SVM based group difference analysis competitive with standard univariate group difference analysis methods.

  14. An Analytical Analysis of CDT Coupled to Dimer-like Matter

    CERN Document Server

    Atkin, Max R


    We consider a model of restricted dimers coupled to two-dimensional causal dynamical triangulations (CDT), where the dimer configurations are restricted in the sense that they do not include dimers in regions of high curvature. It is shown how the model can be solved analytically using bijections with decorated trees. At a negative critical value for the dimer fugacity the model undergoes a phase transition at which the critical exponent associated to the geometry changes. This represents the first account of an analytical study of a matter model with two-dimensional interactions coupled to CDT.

  15. Policy-Making Theory as an Analytical Framework in Policy Analysis: Implications for Research Design and Professional Advocacy. (United States)

    Sheldon, Michael R


    Policy studies are a recent addition to the American Physical Therapy Association's Research Agenda and are critical to our understanding of various federal, state, local, and organizational policies on the provision of physical therapist services across the continuum of care. Policy analyses that help to advance the profession's various policy agendas will require relevant theoretical frameworks to be credible. The purpose of this perspective article is to: (1) demonstrate the use of a policy-making theory as an analytical framework in a policy analysis and (2) discuss how sound policy analysis can assist physical therapists in becoming more effective change agents, policy advocates, and partners with other relevant stakeholder groups. An exploratory study of state agency policy responses to address work-related musculoskeletal disorders is provided as a contemporary example to illustrate key points and to demonstrate the importance of selecting a relevant analytical framework based on the context of the policy issue under investigation.

  16. GeneAnalytics: An Integrative Gene Set Analysis Tool for Next Generation Sequencing, RNAseq and Microarray Data (United States)

    Ben-Ari Fuchs, Shani; Lieder, Iris; Mazor, Yaron; Buzhor, Ella; Kaplan, Sergey; Bogoch, Yoel; Plaschkes, Inbar; Shitrit, Alina; Rappaport, Noa; Kohn, Asher; Edgar, Ron; Shenhav, Liraz; Safran, Marilyn; Lancet, Doron; Guan-Golan, Yaron; Warshawsky, David; Shtrichman, Ronit


    Abstract Postgenomics data are produced in large volumes by life sciences and clinical applications of novel omics diagnostics and therapeutics for precision medicine. To move from “data-to-knowledge-to-innovation,” a crucial missing step in the current era is, however, our limited understanding of biological and clinical contexts associated with data. Prominent among the emerging remedies to this challenge are the gene set enrichment tools. This study reports on GeneAnalytics™ (, a comprehensive and easy-to-apply gene set analysis tool for rapid contextualization of expression patterns and functional signatures embedded in the postgenomics Big Data domains, such as Next Generation Sequencing (NGS), RNAseq, and microarray experiments. GeneAnalytics' differentiating features include in-depth evidence-based scoring algorithms, an intuitive user interface and proprietary unified data. GeneAnalytics employs the LifeMap Science's GeneCards suite, including the GeneCards®—the human gene database; the MalaCards—the human diseases database; and the PathCards—the biological pathways database. Expression-based analysis in GeneAnalytics relies on the LifeMap Discovery®—the embryonic development and stem cells database, which includes manually curated expression data for normal and diseased tissues, enabling advanced matching algorithm for gene–tissue association. This assists in evaluating differentiation protocols and discovering biomarkers for tissues and cells. Results are directly linked to gene, disease, or cell “cards” in the GeneCards suite. Future developments aim to enhance the GeneAnalytics algorithm as well as visualizations, employing varied graphical display items. Such attributes make GeneAnalytics a broadly applicable postgenomics data analyses and interpretation tool for translation of data to knowledge-based innovation in various Big Data fields such as precision medicine, ecogenomics, nutrigenomics

  17. Analysis and Design of I/Q Charge-Sharing Band-Pass-Filter for Superheterodyne Receivers

    NARCIS (Netherlands)

    Madadi, I.; Tohidian, M.; Staszewski, R.B.


    A complex quadrature charge-sharing (CS) technique is proposed to implement a discrete-time band-pass filter (BPF) with a programmable bandwidth of 20–100 MHz. The BPF is part of a cellular superheterodyne receiver and completely determines the receiver frequency selectivity. It operates at the full

  18. Big Data Geo-Analytical Tool Development for Spatial Analysis Uncertainty Visualization and Quantification Needs (United States)

    Rose, K.; Bauer, J. R.; Baker, D. V.


    As big data computing capabilities are increasingly paired with spatial analytical tools and approaches, there is a need to ensure uncertainty associated with the datasets used in these analyses is adequately incorporated and portrayed in results. Often the products of spatial analyses, big data and otherwise, are developed using discontinuous, sparse, and often point-driven data to represent continuous phenomena. Results from these analyses are generally presented without clear explanations of the uncertainty associated with the interpolated values. The Variable Grid Method (VGM) offers users with a flexible approach designed for application to a variety of analyses where users there is a need to study, evaluate, and analyze spatial trends and patterns while maintaining connection to and communicating the uncertainty in the underlying spatial datasets. The VGM outputs a simultaneous visualization representative of the spatial data analyses and quantification of underlying uncertainties, which can be calculated using data related to sample density, sample variance, interpolation error, uncertainty calculated from multiple simulations. In this presentation we will show how we are utilizing Hadoop to store and perform spatial analysis through the development of custom Spark and MapReduce applications that incorporate ESRI Hadoop libraries. The team will present custom 'Big Data' geospatial applications that run on the Hadoop cluster and integrate with ESRI ArcMap with the team's probabilistic VGM approach. The VGM-Hadoop tool has been specially built as a multi-step MapReduce application running on the Hadoop cluster for the purpose of data reduction. This reduction is accomplished by generating multi-resolution, non-overlapping, attributed topology that is then further processed using ESRI's geostatistical analyst to convey a probabilistic model of a chosen study region. Finally, we will share our approach for implementation of data reduction and topology generation

  19. Analytical treatment of system of KdV equations by Homotopy Perturbation Method (HPM and Homotopy Analysis Method (HAM

    Directory of Open Access Journals (Sweden)

    Hafiz Abdul Wahab


    Full Text Available In this article the Homotopy Perturbation Method (HPM and Homotopy Analysis Method (HAM are applied to obtain analytic approximate solution to three system of nonlinear wave equations, namely two component evolutionary system of a homogeneous KdV Equations of order three (system-I as well as (system-II and the generalized coupled Hirota Satsuma KdV (System-III.

  20. Analytic estimation of statistical significance maps for support vector machine based multi-variate image analysis and classification


    Gaonkar, Bilwaj; Davatzikos, Christos


    Multivariate pattern analysis (MVPA) methods such as support vector machines (SVMs) have been increasingly applied to fMRI and sMRI analyses, enabling the detection of distinctive imaging patterns. However, identifying brain regions that significantly contribute to the classification/group separation requires computationally expensive permutation testing. In this paper we show that the results of SVM-permutation testing can be analytically approximated. This approximation leads to more than a...

  1. Innovative methods for data analysis in analytical chemistry using Bayesian statistics and machine learning

    NARCIS (Netherlands)

    Woldegebriel, M.T.


    In analytical chemistry, rapid advancement in instrumentation, especially in high resolution mass-spectrometry is making a significant contribution for further developments of the field. As such, in separation science, nowadays, several hyphenated techniques have proven to be the state-of-the-art te

  2. Methods for Integrating Moderation and Mediation: A General Analytical Framework Using Moderated Path Analysis (United States)

    Edwards, Jeffrey R.; Lambert, Lisa Schurer


    Studies that combine moderation and mediation are prevalent in basic and applied psychology research. Typically, these studies are framed in terms of moderated mediation or mediated moderation, both of which involve similar analytical approaches. Unfortunately, these approaches have important shortcomings that conceal the nature of the moderated…

  3. Instrumental Analysis of Biodiesel Content in Commercial Diesel Blends: An Experiment for Undergraduate Analytical Chemistry (United States)

    Feng, Z. Vivian; Buchman, Joseph T.


    The potential of replacing petroleum fuels with renewable biofuels has drawn significant public interest. Many states have imposed biodiesel mandates or incentives to use commercial biodiesel blends. We present an inquiry-driven experiment where students are given the tasks to gather samples, develop analytical methods using various instrumental…

  4. Stress analysis of fatigue cracks in mechanically fastened joints: an analytical and experimental investigation

    NARCIS (Netherlands)

    De Rijck, J.J.M.


    The two historical fuselage failures, Comet in 1954 and Aloha in 1988, illustrate that similar accidents must be avoided which requires a profound understanding of the fatigue mechanisms involved, including analytical models to predict the fatigue behavior of riveted joints of a fuselage structure.

  5. An Analytical Approach to Low Observable Maintenance Practices Using Simulation and Marginal Analysis (United States)


    more analytical schedule could offer consistency be- tween maintenance units and remove the manual input factor that is currently used. We found that...Technical Infor- mation Center: AD- A320 502/8. AUTHOR BIOGRAPHIES STEPHANIE C. YSEBAERT is an operations research analyst and First Lieutenant in

  6. Classification of a target analyte in solid mixtures using principal component analysis, support vector machines, and Raman spectroscopy (United States)

    O'Connell, Marie-Louise; Howley, Tom; Ryder, Alan G.; Leger, Marc N.; Madden, Michael G.


    The quantitative analysis of illicit materials using Raman spectroscopy is of widespread interest for law enforcement and healthcare applications. One of the difficulties faced when analysing illicit mixtures is the fact that the narcotic can be mixed with many different cutting agents. This obviously complicates the development of quantitative analytical methods. In this work we demonstrate some preliminary efforts to try and account for the wide variety of potential cutting agents, by discrimination between the target substance and a wide range of excipients. Near-infrared Raman spectroscopy (785 nm excitation) was employed to analyse 217 samples, a number of them consisting of a target analyte (acetaminophen) mixed with excipients of different concentrations by weight. The excipients used were sugars (maltose, glucose, lactose, sorbitol), inorganic materials (talcum powder, sodium bicarbonate, magnesium sulphate), and food products (caffeine, flour). The spectral data collected was subjected to a number of pre-treatment statistical methods including first derivative and normalisation transformations, to make the data more suitable for analysis. Various methods were then used to discriminate the target analytes, these included Principal Component Analysis (PCA), Principal Component Regression (PCR) and Support Vector Machines.

  7. LU Peizhang receives Golay Award

    Institute of Scientific and Technical Information of China (English)


    @@ Prof. LU Peizhang, an analytical chemist with the CAS Dalian Institute of Chemical Physics, received the prestigious Golay Award at the 30th International Symposium on Capillary Chromatography opened on 5 June in Dalian, a port city in northeast China's Liaoning Province.

  8. Performance Analysis of a Six-Port Receiver in a WCDMA Communication System including a Multipath Fading Channel

    Directory of Open Access Journals (Sweden)

    A. O. Olopade


    Full Text Available Third generation communication systems require receivers with wide bandwidth of operation to support high transmission rates and are also reconfigurable to support various communication standards with different frequency bands. An ideal software defined radio (SDR will be the absolute answer to this requirement but it is not achievable with the current level of technology. This paper proposes the use of a six-port receiver (SPR front-end (FE in a WCDMA communication system. A WCDMA end-to-end physical layer MATLAB demo which includes a multipath channel distortion block is used to determine the viability of the six-port based receiver. The WCDMA signal after passing through a multipath channel is received using a constructed SPR FE. The baseband signal is then calibrated and corrected in MATLAB. The six-port receiver performance is measured in terms of bit error rate (BER. The signal-to-noise ratio (SNR of the transmitted IQ data is varied and the BER profile of the communication system is plotted. The effect of the multipath fading on the receiver performance and the accuracy of the calibration algorithm are obtained by comparing two different measured BER curves for different calibration techniques to the simulated BER curve of an ideal receiver.

  9. Receiver Design, Performance Analysis, and Evaluation for Space-Borne Laser Altimeters and Space-to-Space Laser Ranging Systems (United States)

    Davidson, Frederic M.; Sun, Xiaoli; Field, Christopher T.


    This progress report consists of two separate reports. The first one describes our work on the use of variable gain amplifiers to increase the receiver dynamic range of space borne laser altimeters such as NASA's Geoscience Laser Altimeter Systems (GLAS). The requirement of the receiver dynamic range was first calculated. A breadboard variable gain amplifier circuit was made and the performance was fully characterized. The circuit will also be tested in flight on board the Shuttle Laser Altimeter (SLA-02) next year. The second report describes our research on the master clock oscillator frequency calibration for space borne laser altimeter systems using global positioning system (GPS) receivers.

  10. Analysis of receiving sensitivity of multi-beam antenna systems with a focal plane array (in Russian)

    CERN Document Server

    Iupikov, O


    In this paper, we present a numerical electromagnetic model of a focal plane array in combination with a multi-channel receiver. Initial experimental validation results are shown that confirm the expected predictions from the model.

  11. A micro-process analysis of Functional Analytic Psychotherapy's mechanism of change. (United States)

    Busch, Andrew M; Kanter, Jonathan W; Callaghan, Glenn M; Baruch, David E; Weeks, Cristal E; Berlin, Kristoffer S


    This study sought to clarify the micro-process of Functional Analytic Psychotherapy (FAP) by using the Functional Analytic Psychotherapy Rating Scale (FAPRS) to code every client and therapist turn of speech over the course of successful treatment of an individual meeting diagnostic criteria for depression and histrionic personality disorder. Treatment consisted of cognitive behavioral therapy alone followed by the addition of FAP techniques in a unique A / A+B design. In-session client behavior improved following the shift to FAP techniques, and micro-process data suggested that client behavior was effectively shaped by in-vivo FAP procedures. These results support FAP's purported mechanisms of change and highlight the advantages of utilizing molecular coding systems to explore these mechanisms.

  12. Analytical determination of orbital elements using Fourier analysis. I. The radial velocity case (United States)

    Delisle, J.-B.; Ségransan, D.; Buchschacher, N.; Alesina, F.


    We describe an analytical method for computing the orbital parameters of a planet from the periodogram of a radial velocity signal. The method is very efficient and provides a good approximation of the orbital parameters. The accuracy is mainly limited by the accuracy of the computation of the Fourier decomposition of the signal which is sensitive to sampling and noise. Our method is complementary with more accurate (and more expensive in computer time) numerical algorithms (e.g. Levenberg-Marquardt, Markov chain Monte Carlo, genetic algorithms). Indeed, the analytical approximation can be used as an initial condition to accelerate the convergence of these numerical methods. Our method can be applied iteratively to search for multiple planets in the same system.

  13. Process analysis of two-layered tube hydroforming with analytical and experimental verification

    Energy Technology Data Exchange (ETDEWEB)

    Seyedkashi, S. M. Hossein [The University of Birjand, Birjand (Iran, Islamic Republic of); Panahizadeh R, Valiollah [Shahid Rajaee Teacher Training University, Tehran (Iran, Islamic Republic of); Xu, Haibin; Kim, Sang Yun; Moon, Young Hoon [Pusan National University, Busan (Korea, Republic of)


    Two-layered tubular joints are suitable for special applications. Designing and manufacturing of two layered components require enough knowledge about the tube material behavior during the hydroforming process. In this paper, hydroforming of two-layered tubes is investigated analytically, and the results are verified experimentally. The aim of this study is to derive an analytical model which can be used in the process design. Fundamental equations are written for both of the outer and inner tubes, and the total forming pressure is obtained from these equations. Hydroforming experiments are carried out on two different combinations of materials for inner and outer tubes; case 1: copper/aluminum and case 2: carbon steel/stainless steel. It is observed that experimental results are in good agreement with the theoretical model obtained for estimation of forming pressure able to avoid wrinkling.

  14. Design, Analysis and Implementation of An Area-Efficient Beam-Steerable Sub-Terahertz Imaging Receiver Array Architecture


    Caster II, Francis


    Multi-pixel passive imaging arrays are presently fabricated in expensive processes with low integration levels. Imaging arrays designed in inexpensive processes with higher levels of integration would result in cheaper larger arrays. The objective of this work is twofold: 1) to develop a highly integrated silicon-based passive imaging receiver integrating the entire receiver frontend from antenna to detector; and 2) to develop a highly scalable architecture for use in focal plane arrays of ar...

  15. IoT Big-Data Centred Knowledge Granule Analytic and Cluster Framework for BI Applications: A Case Base Analysis. (United States)

    Chang, Hsien-Tsung; Mishra, Nilamadhab; Lin, Chung-Chih


    The current rapid growth of Internet of Things (IoT) in various commercial and non-commercial sectors has led to the deposition of large-scale IoT data, of which the time-critical analytic and clustering of knowledge granules represent highly thought-provoking application possibilities. The objective of the present work is to inspect the structural analysis and clustering of complex knowledge granules in an IoT big-data environment. In this work, we propose a knowledge granule analytic and clustering (KGAC) framework that explores and assembles knowledge granules from IoT big-data arrays for a business intelligence (BI) application. Our work implements neuro-fuzzy analytic architecture rather than a standard fuzzified approach to discover the complex knowledge granules. Furthermore, we implement an enhanced knowledge granule clustering (e-KGC) mechanism that is more elastic than previous techniques when assembling the tactical and explicit complex knowledge granules from IoT big-data arrays. The analysis and discussion presented here show that the proposed framework and mechanism can be implemented to extract knowledge granules from an IoT big-data array in such a way as to present knowledge of strategic value to executives and enable knowledge users to perform further BI actions.

  16. IoT Big-Data Centred Knowledge Granule Analytic and Cluster Framework for BI Applications: A Case Base Analysis.

    Directory of Open Access Journals (Sweden)

    Hsien-Tsung Chang

    Full Text Available The current rapid growth of Internet of Things (IoT in various commercial and non-commercial sectors has led to the deposition of large-scale IoT data, of which the time-critical analytic and clustering of knowledge granules represent highly thought-provoking application possibilities. The objective of the present work is to inspect the structural analysis and clustering of complex knowledge granules in an IoT big-data environment. In this work, we propose a knowledge granule analytic and clustering (KGAC framework that explores and assembles knowledge granules from IoT big-data arrays for a business intelligence (BI application. Our work implements neuro-fuzzy analytic architecture rather than a standard fuzzified approach to discover the complex knowledge granules. Furthermore, we implement an enhanced knowledge granule clustering (e-KGC mechanism that is more elastic than previous techniques when assembling the tactical and explicit complex knowledge granules from IoT big-data arrays. The analysis and discussion presented here show that the proposed framework and mechanism can be implemented to extract knowledge granules from an IoT big-data array in such a way as to present knowledge of strategic value to executives and enable knowledge users to perform further BI actions.

  17. Mathematical analysis of recent analytical approximations to the collapse of an empty spherical bubble. (United States)

    Amore, Paolo; Fernández, Francisco M


    We analyze the Rayleigh equation for the collapse of an empty bubble and provide an explanation for some recent analytical approximations to the model. We derive the form of the singularity at the second boundary point and discuss the convergence of the approximants. We also give a rigorous proof of the asymptotic behavior of the coefficients of the power series that are the basis for the approximate expressions.


    Institute of Scientific and Technical Information of China (English)

    李建平; 唐远炎; 严中洪; 张万萍


    Based on sine and cosine functions, the compactly supported orthogonal wavelet filter coefficients with arbitrary length are constructed for the first time. When/N = 2k- 1 and N = 2k , the unified analytic constructions of orthogonal wavelet filters are put forward,respectively. The famous Daubechies filter and some other well-known wavelet filters are tested by the proposed novel method which is very useful for wavelet theory research and many application areas such as pattern recognition.

  19. A semi-automated method for the detection of seismic anisotropy at depth via receiver function analysis (United States)

    Licciardi, A.; Piana Agostinetti, N.


    Information about seismic anisotropy is embedded in the variation of the amplitude of the Ps pulses as a function of the azimuth, on both the Radial and the Transverse components of teleseismic receiver functions (RF). We develop a semi-automatic method to constrain the presence and the depth of anisotropic layers beneath a single seismic broad-band station. An algorithm is specifically designed to avoid trial and error methods and subjective crustal parametrizations in RF inversions, providing a suitable tool for large-size data set analysis. The algorithm couples together information extracted from a 1-D VS profile and from a harmonic decomposition analysis of the RF data set. This information is used to determine the number of anisotropic layers and their approximate position at depth, which, in turn, can be used to, for example, narrow the search boundaries for layer thickness and S-wave velocity in a subsequent parameter space search. Here, the output of the algorithm is used to invert an RF data set by means of the Neighbourhood Algorithm (NA). To test our methodology, we apply the algorithm to both synthetic and observed data. We make use of synthetic RF with correlated Gaussian noise to investigate the resolution power for multiple and thin (1-3 km) anisotropic layers in the crust. The algorithm successfully identifies the number and position of anisotropic layers at depth prior the NA inversion step. In the NA inversion, strength of anisotropy and orientation of the symmetry axis are correctly retrieved. Then, the method is applied to field measurement from station BUDO in the Tibetan Plateau. Two consecutive layers of anisotropy are automatically identified with our method in the first 25-30 km of the crust. The data are then inverted with the retrieved parametrization. The direction of the anisotropic axis in the uppermost layer correlates well with the orientation of the major planar structure in the area. The deeper anisotropic layer is associated with

  20. 3D imaging of the Corinth rift from a new passive seismic tomography and receiver function analysis (United States)

    Godano, Maxime; Gesret, Alexandrine; Noble, Mark; Lyon-Caen, Hélène; Gautier, Stéphanie; Deschamps, Anne


    model and earthquake location. In addition to the tomographic imaging, we perform a preliminary receiver function analysis of teleseismic data recorded by the broadband stations of the CRL network. The RF analysis should provide the interface depths beneath seismometers and increase the imaging resolution of the upper crustal structures provided by the 3D tomography. In this first attempt, we adjust the 1D velocity model that produces a synthetic RF as similar as possible to the observed RF for a subset of data. We compare the identified interfaces with structures imaged by the tomography.

  1. Limitations in the Statistical Analysis of Normalised Cigarette Smoke Analyte Yield per Milligram of Nicotine Yield

    Directory of Open Access Journals (Sweden)

    Cahours X


    Full Text Available Yields of selected mainstream smoke analytes expressed per milligram of nicotine yield (nicotine ratio and ceilings on these ratios have been proposed by WHO as part of future cigarette product regulation. This paper describes the different approaches required for precision assessment, depending on whether yields or nicotine ratios are being studied. The widely used approach of assessment of yield precision is to perform a collaborative study using a standardised method. However, for assessment of ratio precision the measurement of smoke analyte and smoke nicotine yields are often not carried out on the same set of cigarettes (unpaired due to analytical constraints and therefore the statistical approach described in ISO 5725 is inappropriate due to the various replicate combinations. In this paper, the precision of ratios was computed with unpaired measurements for NNN and nicotine yield data for the CM6 monitor test piece and the Kentucky Reference 1R5F cigarette carried out during a collaborative study in 2011 (1. A sampling technique, based on the draw of the most representative ratios, has been used to evaluate the range of both estimated repeatability and reproducibility under the ISO smoking regime that might be expected when comparing data between different laboratories. This statistical evaluation highlighted that a robust estimate of repeatability and reproducibility could not be determined for ratios obtained with unpaired measurements, using the method defined by ISO5725-2.

  2. Analytical Analysis and Field Test Investigation of Consolidation for CCSG Pile Composite Foundation in Soft Clay

    Directory of Open Access Journals (Sweden)

    Jin Yu


    Full Text Available Low-grade concrete-cored sand-gravel (CCSG pile composite foundation is a new kind of composite foundation for thick and soft clay ground treatment. An analytical solution was derived for calculating the consolidation process of this composite foundation by considering coefficients of horizontal permeability in smear zone, the radial flow within the sand-gravel shell, and the impervious property of concrete-cored pile. The results show that Terzaghi’s one-dimensional consolidation solution and the consolidation analytical solution of ordinary composite foundation were special cases of this solution. Curves of the average consolidation degree of the composite foundation under various nondimensional parameters were observed using the program based on the theoretical formula. Meanwhile, a series of in situ measurements including the settlement of pile and soil, the pore water pressure, and the total stress under embankment load were obtained on the CCSG pile composite foundation on a section of Zhenjiang-Liyang highway. The analyzed results show that the new style composite foundation patent technology has many advantages such as small differential postconstruction settlement (differential is not good, small is, reliable quality, high bearing capacity, and stability. And the consolidation of composite foundation is largely affected by the nondimensional parameters. The analytical solution is finally verified with the actual measurement data.

  3. Analytical and numerical analysis of frictional damage in quasi brittle materials (United States)

    Zhu, Q. Z.; Zhao, L. Y.; Shao, J. F.


    Frictional sliding and crack growth are two main dissipation processes in quasi brittle materials. The frictional sliding along closed cracks is the origin of macroscopic plastic deformation while the crack growth induces a material damage. The main difficulty of modeling is to consider the inherent coupling between these two processes. Various models and associated numerical algorithms have been proposed. But there are so far no analytical solutions even for simple loading paths for the validation of such algorithms. In this paper, we first present a micro-mechanical model taking into account the damage-friction coupling for a large class of quasi brittle materials. The model is formulated by combining a linear homogenization procedure with the Mori-Tanaka scheme and the irreversible thermodynamics framework. As an original contribution, a series of analytical solutions of stress-strain relations are developed for various loading paths. Based on the micro-mechanical model, two numerical integration algorithms are exploited. The first one involves a coupled friction/damage correction scheme, which is consistent with the coupling nature of the constitutive model. The second one contains a friction/damage decoupling scheme with two consecutive steps: the friction correction followed by the damage correction. With the analytical solutions as reference results, the two algorithms are assessed through a series of numerical tests. It is found that the decoupling correction scheme is efficient to guarantee a systematic numerical convergence.

  4. Analysis of plant gums and saccharide materials in paint samples: comparison of GC-MS analytical procedures and databases

    Directory of Open Access Journals (Sweden)

    Lluveras-Tenorio Anna


    Full Text Available Abstract Background Saccharide materials have been used for centuries as binding media, to paint, write and illuminate manuscripts and to apply metallic leaf decorations. Although the technical literature often reports on the use of plant gums as binders, actually several other saccharide materials can be encountered in paint samples, not only as major binders, but also as additives. In the literature, there are a variety of analytical procedures that utilize GC-MS to characterize saccharide materials in paint samples, however the chromatographic profiles are often extremely different and it is impossible to compare them and reliably identify the paint binder. Results This paper presents a comparison between two different analytical procedures based on GC-MS for the analysis of saccharide materials in works-of-art. The research presented here evaluates the influence of the analytical procedure used, and how it impacts the sugar profiles obtained from the analysis of paint samples that contain saccharide materials. The procedures have been developed, optimised and systematically used to characterise plant gums at the Getty Conservation Institute in Los Angeles, USA (GCI and the Department of Chemistry and Industrial Chemistry of the University of Pisa, Italy (DCCI. The main steps of the analytical procedures and their optimisation are discussed. Conclusions The results presented highlight that the two methods give comparable sugar profiles, whether the samples analysed are simple raw materials, pigmented and unpigmented paint replicas, or paint samples collected from hundreds of centuries old polychrome art objects. A common database of sugar profiles of reference materials commonly found in paint samples was thus compiled. The database presents data also from those materials that only contain a minor saccharide fraction. This database highlights how many sources of saccharides can be found in a paint sample, representing an important step

  5. Predictors of Outcome in Traumatic Brain Injury: New Insight Using Receiver Operating Curve Indices and Bayesian Network Analysis.

    Directory of Open Access Journals (Sweden)

    Zsolt Zador

    Full Text Available Traumatic brain injury remains a global health problem. Understanding the relative importance of outcome predictors helps optimize our treatment strategies by informing assessment protocols, clinical decisions and trial designs. In this study we establish importance ranking for outcome predictors based on receiver operating indices to identify key predictors of outcome and create simple predictive models. We then explore the associations between key outcome predictors using Bayesian networks to gain further insight into predictor importance.We analyzed the corticosteroid randomization after significant head injury (CRASH trial database of 10008 patients and included patients for whom demographics, injury characteristics, computer tomography (CT findings and Glasgow Outcome Scale (GCS were recorded (total of 13 predictors, which would be available to clinicians within a few hours following the injury in 6945 patients. Predictions of clinical outcome (death or severe disability at 6 months were performed using logistic regression models with 5-fold cross validation. Predictive performance was measured using standardized partial area (pAUC under the receiver operating curve (ROC and we used Delong test for comparisons. Variable importance ranking was based on pAUC targeted at specificity (pAUCSP and sensitivity (pAUCSE intervals of 90-100%. Probabilistic associations were depicted using Bayesian networks.Complete AUC analysis showed very good predictive power (AUC = 0.8237, 95% CI: 0.8138-0.8336 for the complete model. Specificity focused importance ranking highlighted age, pupillary, motor responses, obliteration of basal cisterns/3rd ventricle and midline shift. Interestingly when targeting model sensitivity, the highest-ranking variables were age, severe extracranial injury, verbal response, hematoma on CT and motor response. Simplified models, which included only these key predictors, had similar performance (pAUCSP = 0.6523, 95% CI: 0

  6. Google analytics integrations

    CERN Document Server

    Waisberg, Daniel


    A roadmap for turning Google Analytics into a centralized marketing analysis platform With Google Analytics Integrations, expert author Daniel Waisberg shows you how to gain a more meaningful, complete view of customers that can drive growth opportunities. This in-depth guide shows not only how to use Google Analytics, but also how to turn this powerful data collection and analysis tool into a central marketing analysis platform for your company. Taking a hands-on approach, this resource explores the integration and analysis of a host of common data sources, including Google AdWords, AdSens

  7. Image analysis for a microfluidic paper-based analytical device using the CIE L*a*b* color system. (United States)

    Komatsu, Takeshi; Mohammadi, Saeed; Busa, Lori Shayne Alamo; Maeki, Masatoshi; Ishida, Akihiko; Tani, Hirofumi; Tokeshi, Manabu


    The combination of a microfluidic paper-based analytical device (μPAD) and digital image analysis is widely used for quantitative analysis with μPADs because of its easy and simple operation. Herein, we have demonstrated a quantitative analysis based on multiple color changes on a μPAD. The CIE L*a*b* color system was employed to analyse the digital images obtained with the μPAD. We made pH measurements using a universal pH-indicator showing multiple color changes for various pH values of aqueous test solutions. The detectable pH range of this method was wider than the typical grayscale-based image analysis, and we succeeded in the measurements for a wide pH range of 2-9.

  8. Performance outlook of the SCRAP receiver (United States)

    Lubkoll, Matti; von Backström, Theodor W.; Harms, Thomas M.


    A combined cycle (CC) concentrating solar power (CSP) plant provides significant potential to achieve an efficiency increase and an electricity cost reduction compared to current single-cycle plants. A CC CSP system requires a receiver technology capable of effectively transferring heat from concentrated solar irradiation to a pressurized air stream of a gas turbine. The small number of pressurized air receivers demonstrated to date have practical limitations, when operating at high temperatures and pressures. As yet, a robust, scalable and efficient system has to be developed and commercialized. A novel receiver system, the Spiky Central Receiver Air Pre-heater (SCRAP) concept has been proposed to comply with these requirements. The SCRAP system is conceived as a solution for an efficient and robust pressurized air receiver that could be implemented in CC CSP concepts or standalone solar Brayton cycles without a bottoming Rankine cycle. The presented work expands on previous publications on the thermal modeling of the receiver system. Based on the analysis of a single heat transfer element (spike), predictions for its thermal performance can be made. To this end the existing thermal model was improved by heat transfer characteristics for the jet impingement region of the spike tip as well as heat transfer models simulating the interaction with ambient. While the jet impingement cooling effect was simulated employing a commercial CFD code, the ambient heat transfer model was based on simplifying assumptions in order to employ empirical and analytical equations. The thermal efficiency of a spike under design conditions (flux 1.0 MW/m2, air outlet temperature just below 800 °C) was calculated at approximately 80 %, where convective heat losses account for 16.2 % of the absorbed radiation and radiative heat losses for a lower 2.9 %. This effect is due to peak surface temperatures occurring at the root of the spikes. It can thus be concluded that the geometric

  9. Analytical performance of benchtop total reflection X-ray fluorescence instrumentation for multielemental analysis of wine samples (United States)

    Dalipi, Rogerta; Marguí, Eva; Borgese, Laura; Bilo, Fabjola; Depero, Laura E.


    Recent technological improvements have led to a widespread adoption of benchtop total reflection X-ray fluorescence systems (TXRF) for analysis of liquid samples. However, benchtop TXRF systems usually present limited sensitivity compared with high-scale instrumentation which can restrict its application in some fields. The aim of the present work was to evaluate and compare the analytical capabilities of two TXRF systems, equipped with low power Mo and W target X-ray tubes, for multielemental analysis of wine samples. Using the Mo-TXRF system, the detection limits for most elements were one order of magnitude lower than those attained using the W-TXRF system. For the detection of high Z elements like Cd and Ag, however, W-TXRF remains a very good option due to the possibility of K-Lines detection. Accuracy and precision of the obtained results have been evaluated analyzing spiked real wine samples and comparing the TXRF results with those obtained by inductively coupled plasma emission spectroscopy (ICP-OES). In general, good agreement was obtained between ICP-OES and TXRF results for the analysis of both red and white wine samples except for light elements (i.e., K) which TXRF concentrations were underestimated. However, a further achievement of analytical quality of TXRF results can be achieved if wine analysis is performed after dilution of the sample with de-ionized water.

  10. Crustal structure of Tolfa domes complex (northern Latium - Italy) inferred from receiver functions analysis: an interplay between tectonics and magmatism (United States)

    Buttinelli, M.; Bianchi, I.; Anselmi, M.; Chiarabba, C.; de Rita, D.; Quattrocchi, F.


    The Tolfa-Cerite volcanic district developed along the Tyrrhenian passive margin of central Italy, as part of magmatic processes started during the middle Pliocene. In this area the uncertainties on the deep crustal structures and the definition of the intrusive bodies geometry are focal issues that still need to be addressed. After the onset of the spreading of the Tyrrhenian sea during the Late Miocene, the emplacement of the intrusive bodies of the Tolfa complex (TDC), in a general back-arc geodynamical regime, generally occurred in a low stretching rate, in correspondence of the junctions between major lithospheric discontinuities. Normal faults, located at the edge of Mio-Pliocene basins, were used as preferential pathways for the rising of magmatic masses from the mantle to the surface. We used teleseismic recordings at the TOLF and MAON broad band station of the INGV seismic network (located between the Argentario promontory and Tolfa-Ceriti dome complexes -TDC-) to image the principal seismic velocity discontinuities by receiver function analysis (RF's). Together with RF’s velocity models of the area computed using the teleseismic events recorded by a temporary network of eight stations deployed around the TDC, we achieve a general crustal model of this area. The geometry of the seismic network has been defined to focus on the crustal structure beneath the TDC, trying to define the main velocity changes attributable to the intrusive bodies, the calcareous basal complex, the deep metamorphic basement, the lower crust and the Moho. The analysis of these data show the Moho at a depth of 23 km in the TDC area and 20 km in the Argentario area. Crustal models also show an unexpected velocity decrease between 12 and 18 km, consistent with a slight dropdown of the Vp/Vs ratio, imputable to a regional mid-crustal shear zone inherited from the previous alpine orogenesis, re-activated in extensional tectonic by the early opening phases of the Tyrrhenian sea. Above

  11. Metagenomic analysis of bacterial community composition and antibiotic resistance genes in a wastewater treatment plant and its receiving surface water. (United States)

    Tang, Junying; Bu, Yuanqing; Zhang, Xu-Xiang; Huang, Kailong; He, Xiwei; Ye, Lin; Shan, Zhengjun; Ren, Hongqiang


    The presence of pathogenic bacteria and the dissemination of antibiotic resistance genes (ARGs) may pose big risks to the rivers that receive the effluent from municipal wastewater treatment plants (WWTPs). In this study, we investigated the changes of bacterial community and ARGs along treatment processes of one WWTP, and examined the effects of the effluent discharge on the bacterial community and ARGs in the receiving river. Pyrosequencing was applied to reveal bacterial community composition including potential bacterial pathogen, and Illumina high-throughput sequencing was used for profiling ARGs. The results showed that the WWTP had good removal efficiency on potential pathogenic bacteria (especially Arcobacter butzleri) and ARGs. Moreover, the bacterial communities of downstream and upstream of the river showed no significant difference. However, the increase in the abundance of potential pathogens and ARGs at effluent outfall was observed, indicating that WWTP effluent might contribute to the dissemination of potential pathogenic bacteria and ARGs in the receiving river.

  12. Analysis of Relaxed States in Coaxial Helicity Injection Tokamaks on the Basis of Analytical Solutions

    Institute of Scientific and Technical Information of China (English)

    周登; 张澄


    The principle of the minimum energy dissipation rate is applied to toroidal plasmas with a coaxial direct current helicity injection. The relaxed states are analysed based on the analytical solutions of the resulting Euler-Lagrangian equations. Three typical states are found. The relaxed states are close to the Taylor state if the ratio of current density to magnetic field on the boundary is small enough. The states will deviate from the Taylor state when the ratio increases, but when it approaches a critical value the central part of relaxed plasmas may approach a force free state, and above the critical value both current and magnetic field may reverse in the central part.

  13. Kinematic analysis of a class of analytic planar 3-RPR parallel manipulators

    CERN Document Server

    Wenger, Philippe


    A class of analytic planar 3-RPR manipulators is analyzed in this paper. These manipulators have congruent base and moving platforms and the moving platform is rotated of 180 deg about an axis in the plane. The forward kinematics is reduced to the solution of a 3rd-degree polynomial and a quadratic equation in sequence. The singularities are calculated and plotted in the joint space. The second-order singularities (cups points), which play an important role in non-singular change of assembly-mode motions, are also analyzed.

  14. Pressure analysis for green supply chain management implementation in Indian industries using analytic hierarchy process

    DEFF Research Database (Denmark)

    Mathiyazhagan, K.; Govindan, Kannan; Noorul Haq, A.


    into six groups. Then common acceptable pressures were identified through a questionnaire survey from different industrial sectors in Phase 1. Finally, essential pressures are prioritised with the help of analytic hierarchy process in Phase 2. © 2013 Copyright Taylor and Francis Group, LLC.......Due to growing awareness about environment protection, firms are forced to implement environmental practices to enhance their green image. In recent times, academicians and practitioners have shown interest in green marketing and green supply chain management (GSCM). Fields of green branding...

  15. Using Fuzzy Analytic Hierarchy Process multicriteria and Geographical information system for coastal vulnerability analysis in Morocco: The case of Mohammedia (United States)

    Tahri, Meryem; Maanan, Mohamed; Hakdaoui, Mustapha


    This paper shows a method to assess the vulnerability of coastal risks such as coastal erosion or submarine applying Fuzzy Analytic Hierarchy Process (FAHP) and spatial analysis techniques with Geographic Information System (GIS). The coast of the Mohammedia located in Morocco was chosen as the study site to implement and validate the proposed framework by applying a GIS-FAHP based methodology. The coastal risk vulnerability mapping follows multi-parametric causative factors as sea level rise, significant wave height, tidal range, coastal erosion, elevation, geomorphology and distance to an urban area. The Fuzzy Analytic Hierarchy Process methodology enables the calculation of corresponding criteria weights. The result shows that the coastline of the Mohammedia is characterized by a moderate, high and very high level of vulnerability to coastal risk. The high vulnerability areas are situated in the east at Monika and Sablette beaches. This technical approach is based on the efficiency of the Geographic Information System tool based on Fuzzy Analytical Hierarchy Process to help decision maker to find optimal strategies to minimize coastal risks.

  16. Analytical model for Transient Current Technique (TCT) signal prediction and analysis for thin interface characterization (United States)

    Bronuzzi, J.; Mapelli, A.; Sallese, J. M.


    A silicon wafer bonding technique has been recently proposed for the fabrication of monolithic silicon radiation detectors. This new process would enable direct bonding of a read-out electronic chip wafer on a highly resistive silicon substrate wafer. Therefore, monolithic silicon detectors could be fabricated in this way which would allow the free choice of electronic chips and high resistive silicon bulk, even from different providers. Moreover, a monolithic detector with a high resistive bulk would also be available. Electrical properties of the bonded interface are then critical for this application. Indeed, mobile charges generated by radiation inside the bonded bulk are expected to transit through the interface to be collected by the read-out electronics. In order to characterize this interface, the concept of Transient Current Technique (TCT) has been explored by means of numerical simulations combined with a physics based analytical model. In this work, the analytical model giving insight into the physics behind the TCT dependence upon interface traps is validated using both TCAD simulations and experimental measurements.

  17. Performances of analytical methods for freshwater analysis assessed through intercomparison exercises. II. Major ions.

    Directory of Open Access Journals (Sweden)

    Herbert MUNTAU


    Full Text Available From 1991 to 1997, nine intercomparison exercises on rainwater and freshwater samples were held in the framework of an activity connecting laboratories participating in different projects (Environmental studies in the Mediterranean basin, Italian network for the study of wet deposition, Acidification of mountain lakes, Limnological studies of Lake Léman, Monitoring of atmospheric deposition in forests. The number of participants increased from 72 in 1991 to 177 in 1997. Among the measured variables (pH, conductivity, alkalinity, major ions and nutrients, Ca, Mg, Na, K, ammonium, sulphate, chloride and nitrate are considered in this paper. The methods commonly used by the laboratories involved in the exercises are compared for precision, and an estimate of the performance of each method at different concentrations is made. The results show that some of the participating laboratories use analytical methods which are not reliable for the concentration values occurring in freshwater and/or in rainwater. However, outliers are also produced by laboratories using well-performing methods, indicating the importance of introducing analytical control procedures.

  18. Thermal susceptibility of the Planck-LFI receivers

    Energy Technology Data Exchange (ETDEWEB)

    Terenzi, L; Morgante, G; Butler, R C; Cuttaia, F [INAF - IASF Bologna, via P. Gobetti 101, 40129 Bologna (Italy); Colin, A [Instituto de Fisica de Cantabria (CSIC-UC), Av. Los Castros s/n. 39005 Santander (Spain); Mennella, A; Tomasi, M; Bersanelli, M [Universita degli Studi di Milano, Via Celoria 16, 20133 Milano (Italy); Battaglia, P; Lapolla, M; Franceschet, C [Thales Alenia Space Italia, Sede di Milano, S.S. Padana Superiore 290, 20090, Vimodrone (Italy); D' Arcangelo, O [Istituto di Fisica del Plasma CNR, via Cozzi 53, 20125 Milan (Italy); Davis, R [Jodrell Bank Centre for Astrophysics, Alan Turing Building, University of Manchester, Manchester, M13 9PL (United Kingdom); Galeotta, S [INAF Osservatorio Astronomico di Trieste, via Tiepolo 11, Trieste 34143 (Italy); Gregorio, A [University of Trieste, Department of Physics, via Valerio 2, Trieste 34127 (Italy); Hughes, N; Jukkala, P [DA-Design Oy, Keskuskatu 29, FI-31600, Jokioinen (Finland); Kettle, D [School of Electrical and Electronic Engineering, University of Manchester, Manchester, M60 1QD (United Kingdom); Laaninen, M [Ylinen Electronics Oy, Teollisuustie 9A, FIN-02700 Kauniainen (Finland); Salmon, M J, E-mail: terenzi@iasfbo.inaf.i


    This paper describes the impact of the Planck Low Frequency Instrument front end physical temperature fluctuations on the output signal. The origin of thermal instabilities in the instrument are discussed, and an analytical model of their propagation and impact on the receivers signal is described. The experimental test setup dedicated to evaluate these effects during the instrument ground calibration is reported together with data analysis methods. Finally, main results obtained are discussed and compared to the requirements.

  19. The crust and mantle beneath the Siberian provinces: a preliminary model based on new receiver function analysis

    DEFF Research Database (Denmark)

    Soliman, Mohammad Youssof Ahmad; Artemieva, Irina; Thybo, Hans;


    The new receiver function (RF) study complements the existing seismic data on the crustal and upper mantle structure at the margins of the Siberian craton and the West Siberian Basin. So far, RF studies of Siberia have been largely restricted to the Baikal rift zone (Gao et al., 2004; Liu and Gao...

  20. An Analysis of Vocational Rehabilitation Services for Consumers with Hearing Impairments Who Received College or University Training (United States)

    Boutin, Daniel L.; Wilson, Keith


    The purpose of this study was to determine the predictive ability of vocational rehabilitation services for deaf and hard of hearing consumers who received college and university training. The RSA-911 database for fiscal year 2004 was analyzed to evaluate the effectiveness of 21 services in leading to competitive employment. A model predicting…

  1. Advances in analytical methodology for bioinorganic speciation analysis: metallomics, metalloproteomics and heteroatom-tagged proteomics and metabolomics. (United States)

    Szpunar, Joanna


    The recent developments in analytical techniques capable of providing information on the identity and quantity of heteroatom-containing biomolecules are critically discussed. Particular attention is paid to the emerging areas of bioinorganic analysis including: (i) a comprehensive analysis of the entirety of metal and metalloid species within a cell or tissue type (metallomics), (ii) the study of the part of the metallome involving the protein ligands (metalloproteomics), and (iii) the use of a heteroelement, naturally present in a protein or introduced in a tag added by means of derivatisation, for the spotting and quantification of proteins (heteroatom-tagged proteomics). Inductively coupled plasma mass spectrometry (ICP MS), used as detector in chromatography and electrophoresis, and supported by electrospray and MALDI MS, appears as the linchpin analytical technique for these emerging areas. This review focuses on the recent advances in ICP MS in biological speciation analysis including sensitive detection of non-metals, especially of sulfur and phosphorus, couplings to capillary and nanoflow HPLC and capillary electrophoresis, laser ablation ICP MS detection of proteins in gel electrophoresis, and isotope dilution quantification of biomolecules. The paper can be considered as a followup of a previous review by the author on a similar topic (J. Szpunar, Analyst, 2000, 125, 963).

  2. Analysis of Pre-Analytic Factors Affecting the Success of Clinical Next-Generation Sequencing of Solid Organ Malignancies

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Hui [Department of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 (United States); Luthra, Rajyalakshmi, E-mail:; Goswami, Rashmi S.; Singh, Rajesh R. [Department of Hematopathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 (United States); Roy-Chowdhuri, Sinchita [Department of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 (United States)


    Application of next-generation sequencing (NGS) technology to routine clinical practice has enabled characterization of personalized cancer genomes to identify patients likely to have a response to targeted therapy. The proper selection of tumor sample for downstream NGS based mutational analysis is critical to generate accurate results and to guide therapeutic intervention. However, multiple pre-analytic factors come into play in determining the success of NGS testing. In this review, we discuss pre-analytic requirements for AmpliSeq PCR-based sequencing using Ion Torrent Personal Genome Machine (PGM) (Life Technologies), a NGS sequencing platform that is often used by clinical laboratories for sequencing solid tumors because of its low input DNA requirement from formalin fixed and paraffin embedded tissue. The success of NGS mutational analysis is affected not only by the input DNA quantity but also by several other factors, including the specimen type, the DNA quality, and the tumor cellularity. Here, we review tissue requirements for solid tumor NGS based mutational analysis, including procedure types, tissue types, tumor volume and fraction, decalcification, and treatment effects.

  3. Analysis of Pre-Analytic Factors Affecting the Success of Clinical Next-Generation Sequencing of Solid Organ Malignancies

    Directory of Open Access Journals (Sweden)

    Hui Chen


    Full Text Available Application of next-generation sequencing (NGS technology to routine clinical practice has enabled characterization of personalized cancer genomes to identify patients likely to have a response to targeted therapy. The proper selection of tumor sample for downstream NGS based mutational analysis is critical to generate accurate results and to guide therapeutic intervention. However, multiple pre-analytic factors come into play in determining the success of NGS testing. In this review, we discuss pre-analytic requirements for AmpliSeq PCR-based sequencing using Ion Torrent Personal Genome Machine (PGM (Life Technologies, a NGS sequencing platform that is often used by clinical laboratories for sequencing solid tumors because of its low input DNA requirement from formalin fixed and paraffin embedded tissue. The success of NGS mutational analysis is affected not only by the input DNA quantity but also by several other factors, including the specimen type, the DNA quality, and the tumor cellularity. Here, we review tissue requirements for solid tumor NGS based mutational analysis, including procedure types, tissue types, tumor volume and fraction, decalcification, and treatment effects.

  4. [Microarray analytic system for multiplex analysis by real-time polymerase chain reaction with reagents immobilized in microreactors]. (United States)

    Navolotskiĭ, D V; Perchik, A V; Mark'ianov, I A; Ganeev, A A; Sliadnev, M N


    A microarray analytic system that uses a silicon chip with immobilized in microreactor test-system for multiplex analysis of DNA by real-time polymerase chain reaction (RT-PCR) was developed and optimized. We suggested the method of immobilization of PCR-components of a test-system, chose the stabilizer, and conducted the optimization of the composition of reaction mixture to achieve permanent stability of a microarray. We conducted optimization of preparation of samples using magnetic sorbent and indicated that, with 2.6 x 10(4) copies/ml, 60 min are necessary to obtain positive identification including time for preparation of model probes. The abilities of the created system were demonstrated on the example of microarray analysis of samples with different content of DNA, low absolute limits of identification (20 DNA copies in microreactor), and high reproducibility of the analysis.

  5. Teaching the Analytical Life (United States)

    Jackson, Brian


    Using a survey of 138 writing programs, I argue that we must be more explicit about what we think students should get out of analysis to make it more likely that students will transfer their analytical skills to different settings. To ensure our students take analytical skills with them at the end of the semester, we must simplify the task we…

  6. Analytic Materials

    CERN Document Server

    Milton, Graeme W


    The theory of inhomogeneous analytic materials is developed. These are materials where the coefficients entering the equations involve analytic functions. Three types of analytic materials are identified. The first two types involve an integer $p$. If $p$ takes its maximum value then we have a complete analytic material. Otherwise it is incomplete analytic material of rank $p$. For two-dimensional materials further progress can be made in the identification of analytic materials by using the well-known fact that a $90^\\circ$ rotation applied to a divergence free field in a simply connected domain yields a curl-free field, and this can then be expressed as the gradient of a potential. Other exact results for the fields in inhomogeneous media are reviewed. Also reviewed is the subject of metamaterials, as these materials provide a way of realizing desirable coefficients in the equations.

  7. Analytic trigonometry

    CERN Document Server

    Bruce, William J; Maxwell, E A; Sneddon, I N


    Analytic Trigonometry details the fundamental concepts and underlying principle of analytic geometry. The title aims to address the shortcomings in the instruction of trigonometry by considering basic theories of learning and pedagogy. The text first covers the essential elements from elementary algebra, plane geometry, and analytic geometry. Next, the selection tackles the trigonometric functions of angles in general, basic identities, and solutions of equations. The text also deals with the trigonometric functions of real numbers. The fifth chapter details the inverse trigonometric functions

  8. Astronomical Receiver Modelling Using Scattering Matrices

    CERN Document Server

    King, O G; Copley, C; Davis, R J; Leahy, J P; Leech, J; Muchovej, S J C; Pearson, T J; Taylor, Angela C


    Proper modelling of astronomical receivers is vital: it describes the systematic errors in the raw data, guides the receiver design process, and assists data calibration. In this paper we describe a method of analytically modelling the full signal and noise behaviour of arbitrarily complex radio receivers. We use electrical scattering matrices to describe the signal behaviour of individual components in the receiver, and noise correlation matrices to describe their noise behaviour. These are combined to produce the full receiver model. We apply this approach to a specified receiver architecture: a hybrid of a continous comparison radiometer and correlation polarimeter designed for the C-Band All-Sky Survey. We produce analytic descriptions of the receiver Mueller matrix and noise temperature, and discuss how imperfections in crucial components affect the raw data. Many of the conclusions drawn are generally applicable to correlation polarimeters and continuous comparison radiometers.

  9. Intracavity optogalvanic spectroscopy. An analytical technique for 14C analysis with subattomole sensitivity. (United States)

    Murnick, Daniel E; Dogru, Ozgur; Ilkmen, Erhan


    We show a new ultrasensitive laser-based analytical technique, intracavity optogalvanic spectroscopy, allowing extremely high sensitivity for detection of (14)C-labeled carbon dioxide. Capable of replacing large accelerator mass spectrometers, the technique quantifies attomoles of (14)C in submicrogram samples. Based on the specificity of narrow laser resonances coupled with the sensitivity provided by standing waves in an optical cavity and detection via impedance variations, limits of detection near 10(-15) (14)C/(12)C ratios are obtained. Using a 15-W (14)CO2 laser, a linear calibration with samples from 10(-15) to >1.5 x 10(-12) in (14)C/(12)C ratios, as determined by accelerator mass spectrometry, is demonstrated. Possible applications include microdosing studies in drug development, individualized subtherapeutic tests of drug metabolism, carbon dating and real time monitoring of atmospheric radiocarbon. The method can also be applied to detection of other trace entities.

  10. A nonlinear model arising in the buckling analysis and its new analytic approximate solution

    Energy Technology Data Exchange (ETDEWEB)

    Khan, Yasir [Zhejiang Univ., Hangzhou, ZJ (China). Dept. of Mathematics; Al-Hayani, Waleed [Univ. Carlos III de Madrid, Leganes (Spain). Dept. de Matematicas; Mosul Univ. (Iraq). Dept. of Mathematics


    An analytical nonlinear buckling model where the rod is assumed to be an inextensible column and prismatic is studied. The dimensionless parameters reduce the constitutive equation to a nonlinear ordinary differential equation which is solved using the Adomian decomposition method (ADM) through Green's function technique. The nonlinear terms can be easily handled by the use of Adomian polynomials. The ADM technique allows us to obtain an approximate solution in a series form. Results are presented graphically to study the efficiency and accuracy of the method. To the author's knowledge, the current paper represents a new approach to the solution of the buckling of the rod problem. The fact that ADM solves nonlinear problems without using perturbations and small parameters can be judged as a lucid benefit of this technique over the other methods. (orig.)

  11. Analytical and experimental analysis of stress concentration in notched multilayered composites with finite outer boundaries (United States)

    Hufenbach, W.; Grüber, B.; Gottwald, R.; Lepper, M.; Zhou, B.


    A solution method for stress concentration problems of fibre- and textile-reinforced multilayered composites with account of the influence of a circular or elliptical cut-out and of the finite outer boundary of a composite plate is presented. The method is based on complex-valued displacement functions and conformal mappings in combination with the boundary collocation and least squares methods. This allows a layer-by-layer calculation of full stress, strain, and displacement fields in a generally multilayered anisotropic plate. To verify the calculation model, extensive experimental studies have been carried out. For all the combinations of multilayered GF/PP plates, laminate lay-ups, and notch and specimen dimensions investigated so far, a very good agreement between the analytical calculations and experimental results is found to exist.

  12. Analytical and experimental analysis of a low-pressure heat exchanger suitable for passive ventilation

    DEFF Research Database (Denmark)

    Hviid, Christian Anker; Svendsen, Svend


    AbstractA core element in sustainable ventilation systems is the heat recovery system. Conventional heat recovery systems have a high pressure drop that acts as blockage to naturally driven airflow. The heat recovery system we propose here consists of two separated air-to-liquid heat exchangers...... interconnected by a liquid loop powered by a pump ideal as a component in a heat recovery system for passive ventilation systems. This paper describes the analytical framework and the experimental development of one exchanger in the liquid-loop. The exchanger was constructed from the 8mm plastic tubing...... that is commonly used in water-based floor-heating systems. The pressure loss and temperature exchange efficiency was measured. For a design airflow rate of 560L/s, the pressure loss was 0.37Pa and the efficiency was 75.6%. The experimental results agree well with the literature or numerical fluid calculations...

  13. Towards more complete specifications for acceptable analytical performance - a plea for error grid analysis. (United States)

    Krouwer, Jan S; Cembrowski, George S


    Abstract We examine limitations of common analytical performance specifications for quantitative assays. Specifications can be either clinical or regulatory. Problems with current specifications include specifying limits for only 95% of the results, having only one set of limits that demarcate no harm from minor harm, using incomplete models for total error, not accounting for the potential of user error, and not supplying sufficient protocol requirements. Error grids are recommended to address these problems as error grids account for 100% of the data and stratify errors into different severity categories. Total error estimation from a method comparison can be used to estimate the inner region of an error grid, but the outer region needs to be addressed using risk management techniques. The risk management steps, foreign to many in laboratory medicine, are outlined.

  14. Priority survey between indicators and analytic hierarchy process analysis for green chemistry technology assessment (United States)

    Kim, Sungjune; Hong, Seokpyo; Ahn, Kilsoo; Gong, Sungyong


    Objectives This study presents the indicators and proxy variables for the quantitative assessment of green chemistry technologies and evaluates the relative importance of each assessment element by consulting experts from the fields of ecology, chemistry, safety, and public health. Methods The results collected were subjected to an analytic hierarchy process to obtain the weights of the indicators and the proxy variables. Results These weights may prove useful in avoiding having to resort to qualitative means in absence of weights between indicators when integrating the results of quantitative assessment by indicator. Conclusions This study points to the limitations of current quantitative assessment techniques for green chemistry technologies and seeks to present the future direction for quantitative assessment of green chemistry technologies. PMID:26206364

  15. Comparison of Heat Insulations for Cryogenic Tankers Using Analytical and Numerical Analysis

    Directory of Open Access Journals (Sweden)

    Ramón Miralbés Buil


    Full Text Available This paper presented a methodology for the design of heat insulations used in cryogenic tankers. This insulation usually comprises a combination of vacuum and perlite or vacuum and superinsulation. Concretely, it is a methodology to obtain the temperatures, heat fluxes, and so forth. Using analytical tools has been established, which is based on the equivalence with an electric circuit, and on numerical tools using finite elements. Results obtained with both methods are then compared. In addition, the influence of the outer finish of the external part, due to the effect of the solar radiation, is analyzed too, and the equations to determine the maximum time available to transport the cryogenic liquid have been established. All these aspects are applied to a specific cryogenic commercial vehicle.

  16. Biomarker Analysis of Stored Blood Products: Emphasis on Pre-Analytical Issues

    Directory of Open Access Journals (Sweden)

    Niels Lion


    Full Text Available Millions of blood products are transfused every year; many lives are thus directly concerned by transfusion. The three main labile blood products used in transfusion are erythrocyte concentrates, platelet concentrates and fresh frozen plasma. Each of these products has to be stored according to its particular components. However, during storage, modifications or degradation of those components may occur, and are known as storage lesions. Thus, biomarker discovery of in vivo blood aging as well as in vitro labile blood products storage lesions is of high interest for the transfusion medicine community. Pre-analytical issues are of major importance in analyzing the various blood products during storage conditions as well as according to various protocols that are currently used in blood banks for their preparations. This paper will review key elements that have to be taken into account in the context of proteomic-based biomarker discovery applied to blood banking.

  17. Gravity field error analysis for pendulum formations by a semi-analytical approach (United States)

    Li, Huishu; Reubelt, Tilo; Antoni, Markus; Sneeuw, Nico


    Many geoscience disciplines push for ever higher requirements on accuracy, homogeneity and time- and space-resolution of the Earth's gravity field. Apart from better instruments or new observables, alternative satellite formations could improve the signal and error structure compared to Grace. One possibility to increase the sensitivity and isotropy by adding cross-track information is a pair of satellites flying in a pendulum formation. This formation contains two satellites which have different ascending nodes and arguments of latitude, but have the same orbital height and inclination. In this study, the semi-analytical approach for efficient pre-mission error assessment is presented, and the transfer coefficients of range, range-rate and range-acceleration gravitational perturbations are derived analytically for the pendulum formation considering a set of opening angles. The new challenge is the time variations of the opening angle and the range, leading to temporally variable transfer coefficients. This is solved by Fourier expansion of the sine/cosine of the opening angle and the central angle. The transfer coefficients are further applied to assess the error patterns which are caused by different orbital parameters. The simulation results indicate that a significant improvement in accuracy and isotropy is obtained for small and medium initial opening angles of single polar pendulums, compared to Grace. The optimal initial opening angles are 45° and 15° for accuracy and isotropy, respectively. For a Bender configuration, which is constituted by a polar Grace and an inclined pendulum in this paper, the behaviour of results is dependent on the inclination (prograde vs. retrograde) and on the relative baseline orientation (left or right leading). The simulation for a sun-synchronous orbit shows better results for the left leading case.

  18. Hard Data Analytics Problems Make for Better Data Analysis Algorithms: Bioinformatics as an Example. (United States)

    Bacardit, Jaume; Widera, Paweł; Lazzarini, Nicola; Krasnogor, Natalio


    Data mining and knowledge discovery techniques have greatly progressed in the last decade. They are now able to handle larger and larger datasets, process heterogeneous information, integrate complex metadata, and extract and visualize new knowledge. Often these advances were driven by new challenges arising from real-world domains, with biology and biotechnology a prime source of diverse and hard (e.g., high volume, high throughput, high variety, and high noise) data analytics problems. The aim of this article is to show the broad spectrum of data mining tasks and challenges present in biological data, and how these challenges have driven us over the years to design new data mining and knowledge discovery procedures for biodata. This is illustrated with the help of two kinds of case studies. The first kind is focused on the field of protein structure prediction, where we have contributed in several areas: by designing, through regression, functions that can distinguish between good and bad models of a protein's predicted structure; by creating new measures to characterize aspects of a protein's structure associated with individual positions in a protein's sequence, measures containing information that might be useful for protein structure prediction; and by creating accurate estimators of these structural aspects. The second kind of case study is focused on omics data analytics, a class of biological data characterized for having extremely high dimensionalities. Our methods were able not only to generate very accurate classification models, but also to discover new biological knowledge that was later ratified by experimentalists. Finally, we describe several strategies to tightly integrate knowledge extraction and data mining in order to create a new class of biodata mining algorithms that can natively embrace the complexity of biological data, efficiently generate accurate information in the form of classification/regression models, and extract valuable new

  19. Gravity field error analysis for pendulum formations by a semi-analytical approach (United States)

    Li, Huishu; Reubelt, Tilo; Antoni, Markus; Sneeuw, Nico


    Many geoscience disciplines push for ever higher requirements on accuracy, homogeneity and time- and space-resolution of the Earth's gravity field. Apart from better instruments or new observables, alternative satellite formations could improve the signal and error structure compared to uc(Grace). One possibility to increase the sensitivity and isotropy by adding cross-track information is a pair of satellites flying in a pendulum formation. This formation contains two satellites which have different ascending nodes and arguments of latitude, but have the same orbital height and inclination. In this study, the semi-analytical approach for efficient pre-mission error assessment is presented, and the transfer coefficients of range, range-rate and range-acceleration gravitational perturbations are derived analytically for the pendulum formation considering a set of opening angles. The new challenge is the time variations of the opening angle and the range, leading to temporally variable transfer coefficients. This is solved by Fourier expansion of the sine/cosine of the opening angle and the central angle. The transfer coefficients are further applied to assess the error patterns which are caused by different orbital parameters. The simulation results indicate that a significant improvement in accuracy and isotropy is obtained for small and medium initial opening angles of single polar pendulums, compared to uc(Grace). The optimal initial opening angles are 45° and 15° for accuracy and isotropy, respectively. For a Bender configuration, which is constituted by a polar uc(Grace) and an inclined pendulum in this paper, the behaviour of results is dependent on the inclination (prograde vs. retrograde) and on the relative baseline orientation (left or right leading). The simulation for a sun-synchronous orbit shows better results for the left leading case.

  20. Electronic warfare receivers and receiving systems

    CERN Document Server

    Poisel, Richard A


    Receivers systems are considered the core of electronic warfare (EW) intercept systems. Without them, the fundamental purpose of such systems is null and void. This book considers the major elements that make up receiver systems and the receivers that go in them.This resource provides system design engineers with techniques for design and development of EW receivers for modern modulations (spread spectrum) in addition to receivers for older, common modulation formats. Each major module in these receivers is considered in detail. Design information is included as well as performance tradeoffs o

  1. Performance analysis of a Kalina cycle for a central receiver solar thermal power plant with direct steam generation

    DEFF Research Database (Denmark)

    Modi, Anish; Haglind, Fredrik


    Solar thermal power plants have attracted increasing interest in the past few years - with respect to both the design of the various plant components, and extending the operation hours by employing different types of storage systems. One approach to improve the overall plant efficiency is to use...... without corroding the equipment by using suitable additives with the mixture. The purpose of the study reported here was to investigate if there is any benefit of using a Kalina cycle for a direct steam generation, central receiver solar thermal power plant with high live steam temperature (450 C...... direct steam generation with water/steam as both the heat transfer fluid in the solar receivers and the cycle working fluid. This enables operating the plant with higher turbine inlet temperatures. Available literature suggests that it is feasible to use ammonia-water mixtures at high temperatures...

  2. Crustal structure beneath two seismic stations in the Sunda-Banda arc transition zone derived from receiver function analysis

    Energy Technology Data Exchange (ETDEWEB)

    Syuhada, E-mail: [Graduate Research on Earthquake and Active Tectonics (GREAT), Bandung Institute of Technology, Jalan Ganesha 10, Bandung 40132 (Indonesia); Research Centre for Physics - Indonesian Institute of Sciences (LIPI), Kompleks Puspiptek Serpong, Tangsel 15314, Banten Indonesia (Indonesia); Hananto, Nugroho D.; Handayani, Lina [Research Centre for Geotechnology - Indonesian Institute of Sciences (LIPI), Jl. Sangkuriang (Kompleks LIPI) Bandung 40135 (Indonesia); Puspito, Nanang T; Yudistira, Tedi [Faculty of Mining and Petroleum Engineering ITB, Jalan Ganesha 10, Bandung 40132 (Indonesia); Anggono, Titi [Research Centre for Physics - Indonesian Institute of Sciences (LIPI), Kompleks Puspiptek Serpong, Tangsel 15314, Banten Indonesia (Indonesia)


    We analyzed receiver functions to estimate the crustal thickness and velocity structure beneath two stations of Geofon (GE) network in the Sunda-Banda arc transition zone. The stations are located in two different tectonic regimes: Sumbawa Island (station PLAI) and Timor Island (station SOEI) representing the oceanic and continental characters, respectively. We analyzed teleseismic events of 80 earthquakes to calculate the receiver functions using the time-domain iterative deconvolution technique. We employed 2D grid search (H-κ) algorithm based on the Moho interaction phases to estimate crustal thickness and Vp/Vs ratio. We also derived the S-wave velocity variation with depth beneath both stations by inverting the receiver functions. We obtained that beneath station PLAI the crustal thickness is about 27.8 km with Vp/Vs ratio 2.01. As station SOEI is covered by very thick low-velocity sediment causing unstable solution for the inversion, we modified the initial velocity model by adding the sediment thickness estimated using high frequency content of receiver functions in H-κ stacking process. We obtained the crustal thickness is about 37 km with VP/Vs ratio 2.2 beneath station SOEI. We suggest that the high Vp/Vs in station PLAI may indicate the presence of fluid ascending from the subducted plate to the volcanic arc, whereas the high Vp/Vs in station SOEI could be due to the presence of sediment and rich mafic composition in the upper crust and possibly related to the serpentinization process in the lower crust. We also suggest that the difference in velocity models and crustal thicknesses between stations PLAI and SOEI are consistent with their contrasting tectonic environments.

  3. Pyrosequencing Analysis Reveals Changes in Intestinal Microbiota of Healthy Adults Who Received a Daily Dose of Immunomodulatory Probiotic Strains

    Directory of Open Access Journals (Sweden)

    Julio Plaza-Díaz


    Full Text Available The colon microbiota plays a crucial role in human gastrointestinal health. Current attempts to manipulate the colon microbiota composition are aimed at finding remedies for various diseases. We have recently described the immunomodulatory effects of three probiotic strains (Lactobacillus rhamnosus CNCM I-4036, Lactobacillus paracasei CNCM I-4034, and Bifidobacterium breve CNCM I-4035. The goal of the present study was to analyze the compositions of the fecal microbiota of healthy adults who received one of these strains using high-throughput 16S ribosomal RNA gene sequencing. Bacteroides was the most abundant genus in the groups that received L. rhamnosus CNCM I-4036 or L. paracasei CNCM I-4034. The Shannon indices were significantly increased in these two groups. Our results also revealed a significant increase in the Lactobacillus genus after the intervention with L. rhamnosus CNCM I-4036. The initially different colon microbiota became homogeneous in the subjects who received L. rhamnosus CNCM I-4036. While some orders that were initially present disappeared after the administration of L. rhamnosus CNCM I-4036, other orders, such as Sphingobacteriales, Nitrospirales, Desulfobacterales, Thiotrichales, and Synergistetes, were detected after the intervention. In summary, our results show that the intake of these three bacterial strains induced changes in the colon microbiota.

  4. Analytical Expression for the MIMO Channel Capacity

    Institute of Scientific and Technical Information of China (English)

    ZHAO Yifei; ZHAO Ming; XIAO Limin; WANG Jing


    This paper presents analytical expressions for the multiple-input multiple-output (MIMO) channel capacity in frequency-flat Rayleigh fading environments. An exact analytical expression is given for the ergodic capacity for single-input multiple-output (SIMO) channels. The analysis shows that the SIMO channel capacity can be approximated by a Gaussian random variable and that the MIMO channel capacity can be approximated as the sum of multiple SIMO capacities. The SIMO channel results are used to derive approximate closed-form expressions for the MIMO channel ergodic capacity and the complementary cumulative distribution function (CCDF) of the MIMO channel capacity (outage capacity). Simulations show that these theoretical results are good approximations for MIMO systems with an arbitrary number of transmit or receive antennas. Moreover, these analytical expressions are relatively simple which makes them very useful for practical computations.

  5. Analysis and Reflections on the Third Learning Analytics and Knowledge Conference (LAK 2013) (United States)

    Ochoa, Xavier; Suthers, Dan; Verbert, Katrien; Duval, Erik


    Analyzing a conference, especially one as young and focused as LAK, provides the opportunity to observe the structure and contributions of the scientific community around it. This work will perform a Scientometric analysis, coupled with a more in-depth manual content analysis, to extract this insight from the proceedings and program of LAK 2013.…

  6. Flipping the analytical coin : closing the information flow loop in high speed (real time) analysis

    NARCIS (Netherlands)

    Shahroudi, K.E.


    Analysis modules tend to be set up as one way flow of information, i.e a clear distinction between cause and effect or input and output. However, as the speed of analysis approaches real time (or faster than movie rate), it becomes increasingly difficult for an external user to distinguish between c

  7. Content Analysis of Meta-Analytic Studies from I/O Psychology. (United States)

    Cornwell, John M.

    The use of meta-analysis in industrial and organizational psychology has become quite common. Unfortunately, the understanding and research necessary to ensure appropriate application of the technique have not been as widespread. As part of a larger study, a content analysis of meta-analyses from the industrial and organizational psychological…

  8. Analysis of plasticizers in PVC medical devices: Performance comparison of eight analytical methods. (United States)

    Bernard, L; Bourdeaux, D; Pereira, B; Azaroual, N; Barthélémy, C; Breysse, C; Chennell, P; Cueff, R; Dine, T; Eljezi, T; Feutry, F; Genay, S; Kambia, N; Lecoeur, M; Masse, M; Odou, P; Radaniel, T; Simon, N; Vaccher, C; Verlhac, C; Yessad, M; Décaudin, B; Sautou, V


    A wide variety of medical devices (MDs) used in hospitals are made of flexible plasticized polyvinylchloride (PVC). Different plasticizers are present in variable amounts in the PVC matrix of the devices and can leach out into the infused solutions and may enter into contact with the patients. The ARMED(1) project aims to assess the migration of these plasticizers from medical devices and therefore the level of exposure in patients. For the first task of the project, eight methods were developed to directly detect and quantify the plasticizers in the PVC matrix of the MDs. We compared the overall performances of the analytical methods using standardized and validated criteria in order to provide the scientific community with the guidance and the technical specifications of each method for the intended application. We have shown that routine rapid screening could be performed directly on the MDs using the FTIR technique, with cost-effective analyses. LC techniques may also be used, but with limits and only with individual quantification of the main plasticizers expected in the PVC matrix. GC techniques, especially GC-MS, are both more specific and more sensitive than other techniques. NMR is a robust and specific technique to precisely discriminate all plasticizers in a MD but is limited by its cost and its low ability to detect and quantify plasticizer contamination, e.g. by DEHP. All these results have been confirmed by a real test, called the " blind test " carried out on 10 MD samples.

  9. Ambient aerodynamic ionization source for remote analyte sampling and mass spectrometric analysis. (United States)

    Dixon, R Brent; Sampson, Jason S; Hawkridge, Adam M; Muddiman, David C


    The use of aerodynamic devices in ambient ionization source development has become increasingly prevalent in the field of mass spectrometry. In this study, an air ejector has been constructed from inexpensive, commercially available components to incorporate an electrospray ionization emitter within the exhaust jet of the device. This novel aerodynamic device, herein termed remote analyte sampling, transport, and ionization relay (RASTIR) was used to remotely sample neutral species in the ambient and entrain them into an electrospray plume where they were subsequently ionized and detected using a linear ion trap Fourier transform mass spectrometer. Two sets of experiments were performed in the ambient environment to demonstrate the device's utility. The first involved the remote (approximately 1 ft) vacuum collection of pure sample particulates (i.e., dry powder) from a glass slide, entrainment and ionization at the ESI emitter, and mass spectrometric detection. The second experiment involved the capture (vacuum collection) of matrix-assisted laser desorbed proteins followed by entrainment in the ESI emitter plume, multiple charging, and mass spectrometric detection. This approach is in principle a RASTIR-assisted matrix-assisted laser desorption electrospray ionization source (Sampson, J. S.; Hawkridge, A. M.; Muddiman, D. C. J. Am. Soc. Mass Spectrom. 2006, 17, 1712-1716; Rapid Commun. Mass Spectrom. 2007, 21, 1150-1154.). A detailed description of the device construction, operational parameters, and preliminary small molecule and protein data are presented.

  10. Material degradation due to moisture and temperature. Part 1: mathematical model, analysis, and analytical solutions (United States)

    Xu, C.; Mudunuru, M. K.; Nakshatrala, K. B.


    The mechanical response, serviceability, and load-bearing capacity of materials and structural components can be adversely affected due to external stimuli, which include exposure to a corrosive chemical species, high temperatures, temperature fluctuations (i.e., freezing-thawing), cyclic mechanical loading, just to name a few. It is, therefore, of paramount importance in several branches of engineering—ranging from aerospace engineering, civil engineering to biomedical engineering—to have a fundamental understanding of degradation of materials, as the materials in these applications are often subjected to adverse environments. As a result of recent advancements in material science, new materials such as fiber-reinforced polymers and multi-functional materials that exhibit high ductility have been developed and widely used, for example, as infrastructural materials or in medical devices (e.g., stents). The traditional small-strain approaches of modeling these materials will not be adequate. In this paper, we study degradation of materials due to an exposure to chemical species and temperature under large strain and large deformations. In the first part of our research work, we present a consistent mathematical model with firm thermodynamic underpinning. We then obtain semi-analytical solutions of several canonical problems to illustrate the nature of the quasi-static and unsteady behaviors of degrading hyperelastic solids.

  11. Recursive organizer (ROR): an analytic framework for sequence-based association analysis. (United States)

    Zhao, Lue Ping; Huang, Xin


    The advent of next-generation sequencing technologies affords the ability to sequence thousands of subjects cost-effectively, and is revolutionizing the landscape of genetic research. With the evolving genotyping/sequencing technologies, it is not unrealistic to expect that we will soon obtain a pair of diploidic fully phased genome sequences from each subject in the near future. Here, in light of this potential, we propose an analytic framework called, recursive organizer (ROR), which recursively groups sequence variants based upon sequence similarities and their empirical disease associations, into fewer and potentially more interpretable super sequence variants (SSV). As an illustration, we applied ROR to assess an association between HLA-DRB1 and type 1 diabetes (T1D), discovering SSVs of HLA-DRB1 with sequence data from the Wellcome Trust Case Control Consortium. Specifically, ROR reduces 36 observed unique HLA-DRB1 sequences into 8 SSVs that empirically associate with T1D, a fourfold reduction of sequence complexity. Using HLA-DRB1 data from Type 1 Diabetes Genetics Consortium as cases and data from Fred Hutchinson Cancer Research Center as controls, we are able to validate associations of these SSVs with T1D. Further, SSVs consist of nine nucleotides, and each associates with its corresponding amino acids. Detailed examination of these selected amino acids reveals their potential functional roles in protein structures and possible implication to the mechanism of T1D.

  12. Analytical expressions for chatter analysis in milling operations with one dominant mode (United States)

    Iglesias, A.; Munoa, J.; Ciurana, J.; Dombovari, Z.; Stepan, G.


    In milling, an accurate prediction of chatter is still one of the most complex problems in the field. The presence of these self-excited vibrations can spoil the surface of the part and can also cause a large reduction in tool life. The stability diagrams provide a practical selection of the optimum cutting conditions determined either by time domain or frequency domain based methods. Applying these methods parametric or parameter traced representations of the linear stability limits can be achieved by solving the corresponding eigenvalue problems. In this work, new analytical formulae are proposed related to the parameter domains of both Hopf and period doubling type stability boundaries emerging in the regenerative mechanical model of time periodical milling processes. These formulae are useful to enrich and speed up the currently used numerical methods. Also, the destabilization mechanism of double period chatter is explained, creating an analogy with the chatter related to the Hopf bifurcation, considering one dominant mode and using concepts established by the Pioneers of chatter research.

  13. Analytical analysis of modulated signal in apertureless scanning near-field optical microscopy. (United States)

    Lo, Y L; Chuang, C H


    Eliminating background-scattering effects from the detected signal is crucial in improving the performance of super-high-resolution apertureless scanning near-field optical microscopy (A-SNOM). Using a simple mathematical model of the A-SNOM detected signal, this study explores the respective effects of the phase modulation depth, the wavelength and angle of the incident light, and the amplitude of the tip vibration on the signal contrast and signal intensity. In general, the results show that the background-noise decays as the order of the Bessel function increases and that higher-order harmonic frequencies yield an improved signal contrast. Additionally, it is found that incident light with a longer wavelength improves the signal contrast for a constant order of modulation frequency. The signal contrast can also be improved by reducing the incident angle of the incident light. Finally, it is demonstrated that sample stage scanning yields an improved imaging result. However, tip scanning provides a reasonable low-cost and faster solution in the smaller scan area. The analytical results presented in this study enable a better understanding of the complex detected signal in A-SNOM and provide insights into methods of improving the signal contrast of the A-SNOM measurement.

  14. 2.5D S-wave velocity model of the TESZ area in northern Poland from receiver function analysis (United States)

    Wilde-Piorko, Monika; Polkowski, Marcin; Grad, Marek


    Receiver function (RF) locally provides the signature of sharp seismic discontinuities and information about the shear wave (S-wave) velocity distribution beneath the seismic station. The data recorded by "13 BB Star" broadband seismic stations (Grad et al., 2015) and by few PASSEQ broadband seismic stations (Wilde-Piórko et al., 2008) are analysed to investigate the crustal and upper mantle structure in the Trans-European Suture Zone (TESZ) in northern Poland. The TESZ is one of the most prominent suture zones in Europe separating the young Palaeozoic platform from the much older Precambrian East European craton. Compilation of over thirty deep seismic refraction and wide angle reflection profiles, vertical seismic profiling in over one hundred thousand boreholes and magnetic, gravity, magnetotelluric and thermal methods allowed for creation a high-resolution 3D P-wave velocity model down to 60 km depth in the area of Poland (Grad et al. 2016). On the other hand the receiver function methods give an opportunity for creation the S-wave velocity model. Modified ray-tracing method (Langston, 1977) are used to calculate the response of the structure with dipping interfaces to the incoming plane wave with fixed slowness and back-azimuth. 3D P-wave velocity model are interpolated to 2.5D P-wave velocity model beneath each seismic station and synthetic back-azimuthal sections of receiver function are calculated for different Vp/Vs ratio. Densities are calculated with combined formulas of Berteussen (1977) and Gardner et al. (1974). Next, the synthetic back-azimuthal sections of RF are compared with observed back-azimuthal sections of RF for "13 BB Star" and PASSEQ seismic stations to find the best 2.5D S-wave models down to 60 km depth. National Science Centre Poland provided financial support for this work by NCN grant DEC-2011/02/A/ST10/00284.

  15. An analysis of the incidence and related factors for radiation dermatitis in breast cancer patients who receive radiation therapy

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Sun Young; Kwon, Hyoung Cheol; Kim, Jung Soo [Dept. of Radiation Oncology, Chonbuk National University Hospital, Jeonju (Korea, Republic of); Lee, Heui Kwan [Prebyterian Medical Center, Jeonju (Korea, Republic of)


    We analyzed the incidence and related factors of radiation dermatitis; at first, to recognize whether a decrease in radiation dermatitis is possible or not in breast cancer patients who received radiation therapy. Of 338 patients, 284 with invasive breast cancer who received breast conservation surgery with radiotherapy at Chonbuk National University Hospital from January 2007 to June 2009 were evaluated. Patients who also underwent bolus, previous contralateral breast irradiation and irradiation on both breasts were excluded. For patients who appeared to have greater than moderate radiation dermatitis, the incidence and relating factors for radiation dermatitis were analyzed retrospectively. A total of 207 and 77 patients appeared to have RTOG grade 0/1 or above RTOG grade 2 radiation dermatitis, respectively. The factors found to be statistically significant for the 77 patients who appeared to have greater than moderate radiation dermatitis include the presence of lymphocele due to the stasis of lymph and lymph edema which affect the healing disturbance of radiation dermatitis (p=0.003, p=0.001). Moreover, an allergic reaction to plaster due to the immune cells of skin and the activation of cytokine and concomitant hormonal therapy were also statistically significant factors (p=0.001, p=0.025). Most of the breast cancer patients who received radiation therapy appeared to have a greater than mild case of radiation dermatitis. Lymphocele, lymphedema, an allergy to plaster and concomitant hormonal therapy which affect radiation dermatitis were found to be significant factors. Consequently, we should eliminate lymphocele prior to radiation treatment for patients who appear to have an allergic reaction to plaster. We should also instruct patients of methods to maintain skin moisture if they appear to have a greater than moderate case of radiation dermatitis.

  16. Extreme Scale Visual Analytics

    Energy Technology Data Exchange (ETDEWEB)

    Steed, Chad A [ORNL; Potok, Thomas E [ORNL; Pullum, Laura L [ORNL; Ramanathan, Arvind [ORNL; Shipman, Galen M [ORNL; Thornton, Peter E [ORNL; Potok, Thomas E [ORNL


    Given the scale and complexity of today s data, visual analytics is rapidly becoming a necessity rather than an option for comprehensive exploratory analysis. In this paper, we provide an overview of three applications of visual analytics for addressing the challenges of analyzing climate, text streams, and biosurveilance data. These systems feature varying levels of interaction and high performance computing technology integration to permit exploratory analysis of large and complex data of global significance.

  17. The Thirty Gigahertz Instrument Receiver for the QUIJOTE Experiment: Preliminary Polarization Measurements and Systematic-Error Analysis. (United States)

    Casas, Francisco J; Ortiz, David; Villa, Enrique; Cano, Juan L; Cagigas, Jaime; Pérez, Ana R; Aja, Beatriz; Terán, J Vicente; de la Fuente, Luisa; Artal, Eduardo; Hoyland, Roger; Génova-Santos, Ricardo


    This paper presents preliminary polarization measurements and systematic-error characterization of the Thirty Gigahertz Instrument receiver developed for the QUIJOTE experiment. The instrument has been designed to measure the polarization of Cosmic Microwave Background radiation from the sky, obtaining the Q, U, and I Stokes parameters of the incoming signal simultaneously. Two kinds of linearly polarized input signals have been used as excitations in the polarimeter measurement tests in the laboratory; these show consistent results in terms of the Stokes parameters obtained. A measurement-based systematic-error characterization technique has been used in order to determine the possible sources of instrumental errors and to assist in the polarimeter calibration process.

  18. Geochemical analysis of soils and sediments, Coeur d'Alene drainage basin, Idaho: sampling, analytical methods, and results (United States)

    Box, Stephen E.; Bookstrom, Arthur A.; Ikramuddin, Mohammed; Lindsay, James


    This report presents the locations, descriptions, analytical procedures used, and an inter-lab comparison of over 1100 geochemical analyses of samples of soil and sediment in and downstream of a major lead-zinc-silver mining district in the Coeur d'Alene (CdA) drainage basin of northern Idaho. The samples fall in 3 broad categories: (1) samples from vertical profiles of floodplain soils in the valley of the main stem of the CdA River (767 samples) and of the South Fork of the CdA River (38 samples), (2) size fractionated surficial samples of sediment bedload within the channel of the South Fork of the CdA River (68 samples), and (3) samples from vertical profiles of sediment bedload within the channel of the main stem of the CdA River (260 samples). Five different laboratories contributed geochemical data for this report. Four of the five laboratories employed analytical methods that require sample dissolution prior to analysis; one laboratory (US Geological Survey) used analytical instrumentation (energy dispersive x-ray fluorescence [EDXRF]) that is applied to pulverized samples. Some dissolution procedures use four acids (hydrochloric, nitric, perchloric, and hydrofluoric; Eastern Washington University [EWU] Geochemical Laboratory and XRAL Laboratories, Inc.), others use two acids (nitric acid and aqua regia; CHEMEX Labs, Inc.), and some use only concentrated nitric acid (ACZ Laboratories, Inc.). Most analyses of dissolved samples were done by Inductively Coupled Plasma - Atomic Emission Spectroscopy (ICP-AES) or by ICP - MS (Mass Spectroscopy). Some analyses for Ag and K were done by Flame Atomic Absorption (FAA). Inter-laboratory comparisons are made for 6 elements: lead (Pb), zinc (Zn), iron

  19. Fuzzy surfaces in GIS and geographical analysis theory, analytical methods, algorithms and applications

    CERN Document Server

    Lodwick, Weldon


    Surfaces are a central to geographical analysis. Their generation and manipulation are a key component of geographical information systems (GISs). However, geographical surface data is often not precise. When surfaces are used to model geographical entities, the data inherently contains uncertainty in terms of both position and attribute. Fuzzy Surface in GIS and Geographical Analysis sets out a process to identify the uncertainty in geographic entities. It describes how to successfully obtain, model, analyze, and display data, as well as interpret results within the context of GIS. Focusing on uncertainty that arises from transitional boundaries, the book limits its study to three types of uncertainties: intervals, fuzzy sets, and possibility distributions. The book explains that uncertainty in geographical data typically stems from these three and it is only natural to incorporate them into the analysis and display of surface data. The book defines the mathematics associated with each method for analysis,...

  20. Mechanisms and mediation in survival analysis: towards an integrated analytical framework.

    LENUS (Irish Health Repository)

    Haase, Trutz


    A wide-ranging debate has taken place in recent years on mediation analysis and causal modelling, raising profound theoretical, philosophical and methodological questions. The authors build on the results of these discussions to work towards an integrated approach to the analysis of research questions that situate survival outcomes in relation to complex causal pathways with multiple mediators. The background to this contribution is the increasingly urgent need for policy-relevant research on the nature of inequalities in health and healthcare.

  1. Analysis Problem of Baitul Maal Wat Tamwil (BMT Operation in Pekanbaru Indonesia Using Analytical Network Process (ANP Approach

    Directory of Open Access Journals (Sweden)



    Full Text Available BMT is a financial institution which is sought after by small entrepreneurs for financing their business operations. This institution provides finance to help small entrepreneurs who cannot access finance from the larger banking sector. In addition, the existence of BMTs is a blessing for the lower income group in society, keeping them away from illegal money lenders who burden them with much higher interest rates. Since its appearance in 1992, the BMT has been receiving positive responses from all sections of society in Indonesia. Many people take advantage of these opportunities which are available through the setting up of a BMT institution; however, many of them failed and ended up bankrupt. It is because they faced many problems in their operations. Therefore, this research selected BMT in Pekanbaru as a case study in order to analyze the problems faced by BMT whether these problems due to internal or external factors. In this regard, the study employs the method of Analytic Network Process (ANP. The data used are primary data obtained from interviews (depth interview with academicians, practitioners, and regulators, who have an understanding of the subject matter covered. This paper concluded that the internal problems of lacking quality of Human resource become a major problem to be resolved through training and education. While externally, the major problem that must be immediately to resolve is the absence of specific regulation governing BMT.

  2. Spatial Analysis in Determination Of Flood Prone Areas Using Geographic Information System and Analytical Hierarchy Process at Sungai Sembrong's Catchment (United States)

    Bukari, S. M.; Ahmad, M. A.; Wai, T. L.; Kaamin, M.; Alimin, N.


    Floods that struck Johor state in 2006 and 2007 and the East Coastal in 2014 have triggered a greatly impact to the flood management here in Malaysia. Accordingly, this study conducted to determine potential areas of flooding, especially in Batu Pahat district since it faces terrifying experienced with heavy flood. This objective is archived by using the application of Geographic Information Systems (GIS) on study area of flood risk location at the watershed area of Sungai Sembrong. GIS functions as spatial analysis is capable to produce new information based on analysis of data stored in the system. Meanwhile the Analytical Hierarchy Process (AHP) was used as a method for setting up in decision making concerning the existing data. By using AHP method, preparation and position of the criteria and parameters required in GIS are neater and easier to analyze. Through this study, a flood prone area in the watershed of Sungai Sembrong was identified with the help of GIS and AHP. Analysis was conducted to test two different cell sizes, which are 30 and 5. The analysis of flood prone areas were tested on both cell sizes with two different water levels and the results of the analysis were displayed by GIS. Therefore, the use of AHP and GIS are effective and able to determine the potential flood plain areas in the watershed area of Sungai Sembrong.

  3. Experimental and Analytical Analysis of Mechanical Response and Deformation Mode Selection in Balsa Wood (United States)

    Vural, Murat; Ravichandran, Guruswami

    This study investigates the influence of relative density and strain rate on the compressive response of balsa wood as a sandwich core material commonly used in naval structures. Compressive strength, plateau stress and densification strain of balsa wood along the grain direction is investigated over its entire density spectrum ranging from 55 to 380kg/m3 at both quasi-static (10-3 s-3) and dynamic (103 s-3) strain rates using a modified Kolsky (split Hopkinson) bar. Scanning electron microscopy is used on recovered specimens subjected to controlled loading histories to identify the failure mode selection as a function of density and strain rate. The results indicate that compressive strength of balsa wood increases with relative density though the rate of increase is significantly larger at high strain rates. The failure of low-density specimens is governed by elastic and/or plastic buckling, while kink band formation and end-cap collapse dominate in higher density balsa specimens. Based on the experimental results and observations, several analytical models are proposed to predict the quasi-static compressive strength of balsa wood under uniaxial loading conditions. Results also show that the initial failure stress is very sensitive to the rate of loading, and the degree of dynamic strength enhancement is different for buckling and kink band modes. Kinematics of deformation of the observed failure modes and associated micro-inertial effects are modeled to explain this different behavior. Specific energy dissipation capacity of balsa wood was computed and is found to be comparable with those of fiber-reinforced polymer composites.

  4. Analytic geometry

    CERN Document Server

    Burdette, A C


    Analytic Geometry covers several fundamental aspects of analytic geometry needed for advanced subjects, including calculus.This book is composed of 12 chapters that review the principles, concepts, and analytic proofs of geometric theorems, families of lines, the normal equation of the line, and related matters. Other chapters highlight the application of graphing, foci, directrices, eccentricity, and conic-related topics. The remaining chapters deal with the concept polar and rectangular coordinates, surfaces and curves, and planes.This book will prove useful to undergraduate trigonometric st

  5. Application of semi-analytical mathematical approach for thermal analysis of convective-radiative fin with variable specific heat

    Directory of Open Access Journals (Sweden)

    J. Dutta


    Full Text Available This research paper depicts the application of highly powerful and accurate semi-analytical methods, Differential transformation method (DTM to portray the non linear temperature distribution of convective-radiative fin with variable specific heat. With the help of DTM, the nonlinear terms appeared in governing equations are reduced to recurrence relation with non-dimensional terms. A longitudinal fin of constant rectangular profile through which air flows in transverse direction at ambient temperature has been considered for present analysis. The governing differential equation and corresponding boundary conditions are decided based on the heat transfer in longitudinal fin. The governing equation is non-dimensionalised for successful application of DTM with generalised terms. The results of temperature distribution in fin have been obtained for a range of values of several parameters of DTM. The results have indicated that DTM is efficient and convenient tool for analysing nonlinear differential equations of several environments. Present results have been compared and analysed with other analytical methods available in literature.

  6. 2-D Analysis of Enhancement of Analytes Adsorption Due to Flow Stirring by Electrothermal Force in The Microcantilever Sensor

    CERN Document Server

    Wu, M C; Yang, C -K


    Ac electrokinetic flows are commonly used for manipulating micron-scale particles in a biosensor system. At the solid-liquid state there are two kinds of processes in the reaction between analytes and ligands: the mass transport process and the chemical reaction process. The mass transport process is related to convection and diffusion. Total or partial limit of mass transport would retard the diffusion from the bulk fluid to the interface of reaction. This effect decreases the possibility of adsorption of analyte and ligand because the chemical reaction is faster than the diffusion. In order to solve this problem, we apply an ac electric field to induce a vortex field by the electrothermal effect, which helps in increasing the rate of diffusion. By using the finite element analysis software, COMSOL Multiphysics, we optimized several parameters of the microelectrode structures and the position of the reacting surface, i.e. the microcantilever, by a simplified 2-D model and a 3-D model. It is successful in acc...

  7. Is food allergen analysis flawed? Health and supply chain risks and a proposed framework to address urgent analytical needs. (United States)

    Walker, M J; Burns, D T; Elliott, C T; Gowland, M H; Mills, E N Clare


    Food allergy is an increasing problem for those affected, their families or carers, the food industry and for regulators. The food supply chain is highly vulnerable to fraud involving food allergens, risking fatalities and severe reputational damage to the food industry. Many facets are being pursued to ameliorate the difficulties including better food labelling and the concept of thresholds of elicitation of allergy symptoms as risk management tools. These efforts depend to a high degree on the ability reliably to detect and quantify food allergens; yet all current analytical approaches exhibit severe deficiencies that jeopardise accurate results being produced particularly in terms of the risks of false positive and false negative reporting. If we fail to realise the promise of current risk assessment and risk management of food allergens through lack of the ability to measure food allergens reproducibly and with traceability to an international unit of measurement, the analytical community will have failed a significant societal challenge. Three distinct but interrelated areas of analytical work are urgently needed to address the substantial gaps identified: (a) a coordinated international programme for the production of properly characterised clinically relevant reference materials and calibrants for food allergen analysis; (b) an international programme to widen the scope of proteomics and genomics bioinformatics for the genera containing the major allergens to address problems in ELISA, MS and DNA methods; (c) the initiation of a coordinated international programme leading to reference methods for allergen proteins that provide results traceable to the SI. This article describes in more detail food allergy, the risks of inapplicable or flawed allergen analyses with examples and a proposed framework, including clinically relevant incurred allergen concentrations, to address the currently unmet and urgently required analytical requirements. Support for the

  8. Analytical solutions in $R+qR^{n}$ cosmology from singularity analysis

    CERN Document Server

    Paliathanasis, Andronikos


    The integrability of higher-order theories of gravity is of importance in the determining the properties of these models and so their viability as models of reality. An important tool in the establishment of integrability is the singularity analysis. We apply this analysis to the case of fourth-order theory of gravity $f(R) = R + qR^{n}$ to establish those values of the free parameters $q$ and $n$ for which integrability in this sense exists. As a prelininary we examine the well-known case of $n = 4/3$.

  9. The Thirty Gigahertz Instrument Receiver for the QUIJOTE Experiment: Preliminary Polarization Measurements and Systematic-Error Analysis

    Directory of Open Access Journals (Sweden)

    Francisco J. Casas


    Full Text Available This paper presents preliminary polarization measurements and systematic-error characterization of the Thirty Gigahertz Instrument receiver developed for the QUIJOTE experiment. The instrument has been designed to measure the polarization of Cosmic Microwave Background radiation from the sky, obtaining the Q, U, and I Stokes parameters of the incoming signal simultaneously. Two kinds of linearly polarized input signals have been used as excitations in the polarimeter measurement tests in the laboratory; these show consistent results in terms of the Stokes parameters obtained. A measurement-based systematic-error characterization technique has been used in order to determine the possible sources of instrumental errors and to assist in the polarimeter calibration process.

  10. The Thirty Gigahertz Instrument Receiver for the QUIJOTE Experiment: Preliminary Polarization Measurements and Systematic-Error Analysis (United States)

    Casas, Francisco J.; Ortiz, David; Villa, Enrique; Cano, Juan L.; Cagigas, Jaime; Pérez, Ana R.; Aja, Beatriz; Terán, J. Vicente; de la Fuente, Luisa; Artal, Eduardo; Hoyland, Roger; Génova-Santos, Ricardo


    This paper presents preliminary polarization measurements and systematic-error characterization of the Thirty Gigahertz Instrument receiver developed for the QUIJOTE experiment. The instrument has been designed to measure the polarization of Cosmic Microwave Background radiation from the sky, obtaining the Q, U, and I Stokes parameters of the incoming signal simultaneously. Two kinds of linearly polarized input signals have been used as excitations in the polarimeter measurement tests in the laboratory; these show consistent results in terms of the Stokes parameters obtained. A measurement-based systematic-error characterization technique has been used in order to determine the possible sources of instrumental errors and to assist in the polarimeter calibration process. PMID:26251906

  11. Widely Linear Equalization for IQ Imbalance and Skew Compensation in Optical Coherent Receivers

    DEFF Research Database (Denmark)

    Porto da Silva, Edson; Zibar, Darko


    In this paper, an alternative approach to design linear equalization algorithms for optical coherent receivers is introduced. Using widely linear complex analysis, a general analytical model it is shown, where In-phase/quadrature (IQ) imbalances and IQ skew at the coherent receiver front......, it is shown that, by applying the widely linear complex analysis, one can derive a complex-valued adaptive equalizer structure which is able to compensate for linear IQ-mixing effects at the receiver front-end. By extensive numerical simulations, the performance versus complexity of the proposed equalizer...

  12. Effects of Lipid Emulsions in Parenteral Nutrition of Esophageal Cancer Surgical Patients Receiving Enteral Nutrition: A Comparative Analysis

    Directory of Open Access Journals (Sweden)

    Wu-Ping Wang


    Full Text Available Background: Olive oil-based lipid emulsion (LE and medium chain triglyceride/long chain triglyceride (MCT/LCT emulsion are both LEs with low ω-6 polyunsaturated fat acids (PUFAs content. However, which one of these LEs is associated with a lower infection risk in patients receiving parenteral nutrition (PN remains unclear. The aim of the study was to compare the effects of the two LEs in PN in esophageal cancer patients undergoing surgery. Methods: Patients with resectable esophageal carcinoma were recruited and allocated randomly to two groups. The test group was given enteral nutrition (EN with PN containing olive oil-based LE after tumor resection for ≥7 days, and the patients in the control group were supported by EN with MCT/LCT emulsion-based PN after surgery for the same time period. Immunological markers and inflammatory indicators were tested and perioperative clinical outcomes were determined. The trial was registered in the Chinese Clinical Trial Register, number ChiCTR-TRC-13003562. 94 Patients were recruited, and grouped (olive oil-based LE, n = 46 and MCT/LCT, n = 48, matched for sex, age, body mass index, histological type, TNM stage, and nutrition risk screening (NRS 2002 score. Results: There were no differences in perioperative fever (>38 °C, infectious complications, length of hospital stay (>14 days, length of critical care stay (>2 days, time for oral food intake, and in-hospital mortality between the two groups. The test group showed a higher increase in IgG level compared with the MCT/LCT group (p = 0.028. There was no difference in other immunological markers and inflammatory indicators between the two groups. Conclusion: PN containing olive oil-based or MCT/LCT LEs had similar effects on perioperative outcome, cell-mediated immune function and inflammatory response in esophageal cancer patients who had undergone surgery and were receiving EN.

  13. Analytical Laboratories (United States)

    Federal Laboratory Consortium — NETL’s analytical laboratories in Pittsburgh, PA, and Albany, OR, give researchers access to the equipment they need to thoroughly study the properties of materials...

  14. Black Boxes in Analytical Chemistry: University Students' Misconceptions of Instrumental Analysis (United States)

    Carbo, Antonio Domenech; Adelantado, Jose Vicente Gimeno; Reig, Francisco Bosch


    Misconceptions of chemistry and chemical engineering university students concerning instrumental analysis have been established from coordinated tests, tutorial interviews and laboratory lessons. Misconceptions can be divided into: (1) formal, involving specific concepts and formulations within the general frame of chemistry; (2)…

  15. Researcher Effects on Mortality Salience Research: A Meta-Analytic Moderator Analysis (United States)

    Yen, Chih-Long; Cheng, Chung-Ping


    A recent meta-analysis of 164 terror management theory (TMT) papers indicated that mortality salience (MS) yields substantial effects (r = 0.35) on worldview and self-esteem-related dependent variables (B. L. Burke, A. Martens, & E. H. Faucher, 2010). This study reanalyzed the data to explore the researcher effects of TMT. By cluster-analyzing…

  16. The Effect of Gender on Organizational Commitment of Teachers: A Meta Analytic Analysis (United States)

    Aydin, Ayhan; Sarier, Yilmaz; Uysal, Sengul


    The purpose of this study is to determine the effect of gender on the organizational commitment of teachers. In this respect, the levels of organizational commitment were also investigated with organizational commitment. Fifteen master and doctorate theses done between 2005-2009 were analyzed using meta analysis. At the end of the research study,…

  17. Information-analytical system for a comprehensive assessment and analysis of the enterprises

    Directory of Open Access Journals (Sweden)

    Baydybekova Saltanat Kenzhebaevna


    Lack of theoretical elaboration and high practical significance the problem of forming the system of internal control and analysis of economic organizations, the need for further development of his theory, methodology and organization, as well as great practical relevance in specific methods and techniques for its implementation led to the choice of research topic and its relevance.

  18. Factor Analysis of People Rather than Variables: Q and Other Two-Mode Factor Analytic Models. (United States)

    Frederick, Brigitte N.

    Factor analysis attempts to study how different objects group together to form factors with the purposes of: (1) reducing the number of factorable entities (e.g., variables) with which the researcher needs to deal; (2) searching data for qualitative and quantitative differences; and (3) testing hypotheses (R. Gorsuch, 1983). While most factor…

  19. An analytical platform for mass spectrometry-based identification and chemical analysis of RNA in ribonucleoprotein complexes. (United States)

    Taoka, Masato; Yamauchi, Yoshio; Nobe, Yuko; Masaki, Shunpei; Nakayama, Hiroshi; Ishikawa, Hideaki; Takahashi, Nobuhiro; Isobe, Toshiaki


    We describe here a mass spectrometry (MS)-based analytical platform of RNA, which combines direct nano-flow reversed-phase liquid chromatography (RPLC) on a spray tip column and a high-resolution LTQ-Orbitrap mass spectrometer. Operating RPLC under a very low flow rate with volatile solvents and MS in the negative mode, we could estimate highly accurate mass values sufficient to predict the nucleotide composition of a approximately 21-nucleotide small interfering RNA, detect post-transcriptional modifications in yeast tRNA, and perform collision-induced dissociation/tandem MS-based structural analysis of nucleolytic fragments of RNA at a sub-femtomole level. Importantly, the method allowed the identification and chemical analysis of small RNAs in ribonucleoprotein (RNP) complex, such as the pre-spliceosomal RNP complex, which was pulled down from cultured cells with a tagged protein cofactor as bait. We have recently developed a unique genome-oriented database search engine, Ariadne, which allows tandem MS-based identification of RNAs in biological samples. Thus, the method presented here has broad potential for automated analysis of RNA; it complements conventional molecular biology-based techniques and is particularly suited for simultaneous analysis of the composition, structure, interaction, and dynamics of RNA and protein components in various cellular RNP complexes.

  20. Analytical solution to stagnation-point flow and heat transfer over a stretching sheet based on homotopy analysis

    Institute of Scientific and Technical Information of China (English)

    Jing ZHU; Lian-cun ZHENG; Xin-xin ZHANG


    This paper is concerned with two-dimensional stagnation-point steady flow of an incompressible viscous fluid towards a stretching sheet whose velocity is proportional to the distance from the slit. The governing system of partial differential equations is first transformed into a system of dimensionless ordinary differential equations. Analytical solutions of the velocity distribution and dimensionless temperature profiles are obtained for different ratios of free stream velocity and stretching velocity, Prandtl number, Eckert number and dimensionality index in series forms using homotopy analysis method(HAM).It is shown that a boundary layer is formed when the free stream velocity exceeds the stretching velocity, and an inverted boundary layer is formed when the free stream velocity is less than the stretching velocity. Graphs are presented to show the effects of different parameters.

  1. Probing primordial non Gaussianity in the BOOMERanG CMB maps: an analysis based on analytical Minkowski functionals

    Energy Technology Data Exchange (ETDEWEB)

    Migliaccio, M.; Natoli, P.; De Troia, G. [Dipartimento di Fisica, Universita di Roma ' Tor Vergata' , Via della Ricerca Scientifica, 1 I-00133 Roma (Italy); Hikage, C. [School of Physics and Astronomy, Cardiff University, Cardiff, CF24 3AA (United Kingdom); Komatsu, E. [Texas Cosmology Center, University of Texas at Austin, 1 University Station, C1400, Austin, TX 78712 (United States); Ade, P.A.R. [School of Physics and Astronomy, Cardiff University, Cardiff, CF24 3AA (United Kingdom); Bock, J.J. [Jet Propulsion Laboratory, Pasadena, CA (United States); Bond, J.R. [Canadian Institute for Theoretical Astrophysics, University of Toronto, Toronto, Ontario (Canada); Borrill, J. [Computational Research Division, Lawrence Berkeley National Laboratory, Berkeley, CA (United States); Boscaleri, A. [IFAC-CNR, Firenze (Italy); Contaldi, C.R. [Theoretical Physics Group, Imperial College, London (United Kingdom); Crill, B.P. [Jet Propulsion Laboratory, Pasadena, CA (United States); Bernardis, P. de [Dipartimento di Fisica, Universita La Sapienza, Roma (Italy); Gasperis, G. de [Dipartimento di Fisica, Universita di Roma ' Tor Vergata' , Via della Ricerca Scientifica, 1 I-00133 Roma (Italy); Oliveira-Costa, A. de [Department of Physics, MIT, Cambridge, MA 02139 (United States); Di Stefano, G. [Istituto Nazionale di Geofisica e Vulcanologia, 00143 Rome (Italy); Hivon, E. [Institut d' Astrophysique, Paris (France); Kisner, T.S. [Computational Research Division, Lawrence Berkeley National Laboratory, Berkeley, CA (United States); Jones, W.C. [Department of Physics, Princeton University, Princeton, NJ 0854 (United States); Lange, A.E. [Observational Cosmology, California Institute of Technology, Pasadena, CA (United States)


    Minkowski functionals are a powerful tool to constrain the Gaussianity of the Cosmic Microwave Background (CMB). In the limit of a weakly non Gaussian field, a perturbative approach can be derived [Hikage C., Komatsu E., and Matsubara T., 2006, ApJ, 653, 11] that is completely based on analytical formulae without requiring computationally intensive, dedicated Monte Carlo non Gaussian simulations of the CMB anisotropy. We apply this machinery to an intensity map derived from the 1998 and 2003 flights of BOOMERanG, analyzed here together for the first time. We set limits on the non-linear coupling parameter f{sub NL} as -1020analysis was limited to the BOOMERanG 2003 dataset. These limits are the most stringent ever set among suborbital experiments.

  2. Rapid process development of chromatographic process using direct analysis in real time mass spectrometry as a process analytical technology tool. (United States)

    Yan, Binjun; Chen, Teng; Xu, Zhilin; Qu, Haibin


    The concept of quality by design (QbD) is widely applied in the process development of pharmaceuticals. However, the additional cost and time have caused some resistance about QbD implementation. To show a possible solution, this work proposed a rapid process development method, which used direct analysis in real time mass spectrometry (DART-MS) as a process analytical technology (PAT) tool for studying the chromatographic process of Ginkgo biloba L., as an example. The breakthrough curves were fast determined by DART-MS at-line. A high correlation coefficient of 0.9520 was found between the concentrations of ginkgolide A determined by DART-MS and HPLC. Based on the PAT tool, the impacts of process parameters on the adsorption capacity were discovered rapidly, which showed a decreased adsorption capacity with the increase of the flow rate. This work has shown the feasibility and advantages of integrating PAT into QbD implementation for rapid process development.

  3. Ion beam analysis and PD-MS as new analytical tools for quality control of pharmaceuticals: comparative study from fluphenazine in solid dosage forms. (United States)

    Nsouli, Bilal; Bejjani, Alice; Negra, Serge Della; Gardon, Alain; Thomas, Jean-Paul


    In order to evaluate the potential of accelerator based analytical techniques ((particle induced X-ray emission (PIXE), particle induced gamma-ray emission (PIGE), and particle desorption mass spectrometry (PD-MS)) for the analysis of commercial pharmaceutical products in their solid dosage form, the fluphenazine drug has been taken as a representative example. It is demonstrated that PIXE and PIGE are by far the best choice for quantification of the active ingredient (AI) (certification with 7% precision) from the reactions induced on its specific heteroatoms fluorine and sulfur using pellets made from original tablets. Since heteroatoms cannot be present in all types of drugs, the PD-MS technique, which makes easily the distinction between AI(s) and excipients, has been evaluated for the same material. It is shown that the quantification of AI is obtained via the detection of its protonated molecule. However, calibration curves have to be made from the secondary ion yield variations since matrix effects of various nature are characteristics of such mixtures of heterogeneous materials (including deposits from soluble components). From the analysis of solid tablets, (either transformed into pellets and even as received), it is strongly suggested that the physical state of the grains in the mixture is a crucial parameter in the ion emission and accordingly for the calibration curves. As a result of our specific (but not optimized) conditions the resulting precision is <17% with an almost linear range extending from 0.04 to 7.87 mg of AI in a tablet made under the manufacturer conditions (the commercial drug product is labeled at 5 mg).

  4. A Multi-facetted Visual Analytics Tool for Exploratory Analysis of Human Brain and Function Datasets. (United States)

    Angulo, Diego A; Schneider, Cyril; Oliver, James H; Charpak, Nathalie; Hernandez, Jose T


    Brain research typically requires large amounts of data from different sources, and often of different nature. The use of different software tools adapted to the nature of each data source can make research work cumbersome and time consuming. It follows that data is not often used to its fullest potential thus limiting exploratory analysis. This paper presents an ancillary software tool called BRAVIZ that integrates interactive visualization with real-time statistical analyses, facilitating access to multi-facetted neuroscience data and automating many cumbersome and error-prone tasks required to explore such data. Rather than relying on abstract numerical indicators, BRAVIZ emphasizes brain images as the main object of the analysis process of individuals or groups. BRAVIZ facilitates exploration of trends or relationships to gain an integrated view of the phenomena studied, thus motivating discovery of new hypotheses. A case study is presented that incorporates brain structure and function outcomes together with different types of clinical data.


    Directory of Open Access Journals (Sweden)

    Pardhi Swati S


    Full Text Available Highly Active antiretroviral therapy ( HAART , a combination drug therapy is a topic of current interest in the treatment of HIV and AIDS. Techniques for the analysis and the quality control of antiretroviral drugs, particularly in the drug combinations are vital in achieving quality of these drugs and the treatments involved. Integrase inhibitor are a class of antiretroviral drug designed to block the action of integrase , a viral enzymes that inserts a viral genome into the DNA of the host cell. Since integration is a vital step in retroviral replication, blocking it can halt further spread of the virus. Integrase inhibitor were initially developed for the treatment of HIV infection . The HPLC,UV and HPTLC methods are available for the analysis of Raltegravir and Elvitegravir, the recently used drug for HIV and AIDS are reviewed in this articles.

  6. Clinical examination and foot pressure analysis of diabetic foot: Prospective analytical study in Indian diabetic patients.

    Directory of Open Access Journals (Sweden)

    Harshanand Popalwar


    Conclusion: Meticulous clinical examination can easily identify diabetic neuropathy and related pathological complications of diabetic foot. This shall help for early diagnosis and prevention of diabetic foot complications. Foot pressure analysis can be useful tool to screen patients of diabetic foot for abnormal high pressure point areas and can predict future risk of ulceration due to high foot pressure. This study states findings in Indian diabetic patients. [Natl J Med Res 2016; 6(1.000: 17-22

  7. Analytic hierarchy process analysis for choosing a corporate social entrepreneurship strategy


    Hadad Shahrazad


    After conducting an extensive analysis of both the specialised literature and practice and identifying three types of corporate social entrepreneurship in my PhD thesis titled “Corporate social entrepreneurship - the new paradigm of reshaping and rethinking business”, I decided to determine which of the three approaches is mostly suited for the Romanian market. The three types of corporate social entrepreneurship: corporate social entrepreneurship as local development tool, corporate social e...

  8. Analytical Solution for the Free Vibration Analysis of Delaminated Timoshenko Beams



    This work presents a method to find the exact solutions for the free vibration analysis of a delaminated beam based on the Timoshenko type with different boundary conditions. The solutions are obtained by the method of Lagrange multipliers in which the free vibration problem is posed as a constrained variational problem. The Legendre orthogonal polynomials are used as the beam eigenfunctions. Natural frequencies and mode shapes of various Timoshenko beams are presented to demonstrate the effi...

  9. Analytical solution for the free vibration analysis of delaminated Timoshenko beams. (United States)

    Jafari-Talookolaei, Ramazan-Ali; Abedi, Maryam


    This work presents a method to find the exact solutions for the free vibration analysis of a delaminated beam based on the Timoshenko type with different boundary conditions. The solutions are obtained by the method of Lagrange multipliers in which the free vibration problem is posed as a constrained variational problem. The Legendre orthogonal polynomials are used as the beam eigenfunctions. Natural frequencies and mode shapes of various Timoshenko beams are presented to demonstrate the efficiency of the methodology.

  10. Nuclear analytical chemistry

    Energy Technology Data Exchange (ETDEWEB)

    Brune, D.; Forkman, B.; Persson, B.


    This book covers the general theories and techniques of nuclear chemical analysis, directed at applications in analytical chemistry, nuclear medicine, radiophysics, agriculture, environmental sciences, geological exploration, industrial process control, etc. The main principles of nuclear physics and nuclear detection on which the analysis is based are briefly outlined. An attempt is made to emphasise the fundamentals of activation analysis, detection and activation methods, as well as their applications. The book provides guidance in analytical chemistry, agriculture, environmental and biomedical sciences, etc. The contents include: the nuclear periodic system; nuclear decay; nuclear reactions; nuclear radiation sources; interaction of radiation with matter; principles of radiation detectors; nuclear electronics; statistical methods and spectral analysis; methods of radiation detection; neutron activation analysis; charged particle activation analysis; photon activation analysis; sample preparation and chemical separation; nuclear chemical analysis in biological and medical research; the use of nuclear chemical analysis in the field of criminology; nuclear chemical analysis in environmental sciences, geology and mineral exploration; and radiation protection.

  11. Long term outcome and side effects in patients receiving low-dose I125 brachytherapy: a retrospective analysis

    Directory of Open Access Journals (Sweden)

    Pieter Logghe

    Full Text Available ABSTRACT Objectives: To retrospectively evaluate the disease free survival (DFS, disease specific survival (DSS,overall survival (OS and side effects in patients who received low-dose rate (LDR brachytherapy with I125 stranded seeds. Materials and methods: Between july 2003 and august 2012, 274 patients with organ confined prostate cancer were treated with permanent I125 brachytherapy. The median follow-up, age and pretreatment prostate specific antigen (iPSA was 84 months (12-120, 67 years (50-83 and 7.8 ng/mL (1.14-38, respectively. Median Gleason score was 6 (3-9. 219 patients (80% had stage cT1c, 42 patients (15.3% had stage cT2a, 3 (1.1% had stage cT2b and 3 (1.1% had stage cT2c. The median D90 was 154.3 Gy (102.7-190.2. Results: DSS was 98.5%.OS was 93.5%. 13 patients (4.7% developed systemic disease, 7 patients (2.55% had local progression. In 139 low risk patients, the 5 year biochemical freedom from failure rate (BFFF was 85% and 9 patients (6.4% developed clinical progression. In the intermediate risk group, the 5 year BFFF rate was 70% and 5 patients (7.1% developed clinical progression. Median nPSA in patients with biochemical relapse was 1.58 ng/mL (0.21 – 10.46, median nPSA in patients in remission was 0.51 ng/mL (0.01 – 8.5. Patients attaining a low PSA nadir had a significant higher BFFF (p<0.05. Median D90 in patients with biochemical relapse was 87.2 Gy (51 – 143,1. Patients receiving a high D90 had a significant higher BFFF (p<0.05. Conclusion: In a well selected patient population, LDR brachytherapy offers excellent outcomes. Reaching a low PSA nadir and attaining high D90 values are significant predictors for a higher DFS.

  12. Error and Performance Analysis of MEMS-based Inertial Sensors with a Low-cost GPS Receiver

    Directory of Open Access Journals (Sweden)

    Yang Gao


    Full Text Available Global Navigation Satellite Systems (GNSS, such as the Global Positioning System (GPS, have been widely utilized and their applications are becoming popular, not only in military or commercial applications, but also for everyday life. Although GPS measurements are the essential information for currently developed land vehicle navigation systems (LVNS, GPS signals are often unavailable or unreliable due to signal blockages under certain environments such as urban canyons. This situation must be compensated in order to provide continuous navigation solutions. To overcome the problems of unavailability and unreliability using GPS and to be cost and size effective as well, Micro Electro Mechanical Systems (MEMS based inertial sensor technology has been pushing for the development of low-cost integrated navigation systems for land vehicle navigation and guidance applications. This paper will analyze the characterization of MEMS based inertial sensors and the performance of an integrated system prototype of MEMS based inertial sensors, a low-cost GPS receiver and a digital compass. The influence of the stochastic variation of sensors will be assessed and modeled by two different methods, namely Gauss-Markov (GM and AutoRegressive (AR models, with GPS signal blockage of different lengths. Numerical results from kinematic testing have been used to assess the performance of different modeling schemes.

  13. Evaluation of Deterministic and Complex Analytical Hierarchy Process Methods for Agricultural Land Suitability Analysis in a Changing Climate

    Directory of Open Access Journals (Sweden)

    Harmen Romeijn


    Full Text Available Land suitability analysis is employed to evaluate the appropriateness of land for a particular purpose whilst integrating both qualitative and quantitative inputs, which can be continuous in nature. However, in agricultural modelling there is often a disregard of this contiguous aspect. Therefore, some parametric procedures for suitability analysis compartmentalise units into defined membership classes. This imposition of crisp boundaries neglects the continuous formations found throughout nature and overlooks differences and inherent uncertainties found in the modelling. This research will compare two approaches to suitability analysis over three differing methods. The primary approach will use an Analytical Hierarchy Process (AHP, while the other approach will use a Fuzzy AHP over two methods; Fitted Fuzzy AHP and Nested Fuzzy AHP. Secondary to this, each method will be assessed into how it behaves in a climate change scenario to understand and highlight the role of uncertainties in model conceptualisation and structure. Outputs and comparisons between each method, in relation to area, proportion of membership classes and spatial representation, showed that fuzzy modelling techniques detailed a more robust and continuous output. In particular the Nested Fuzzy AHP was concluded to be more pertinent, as it incorporated complex modelling techniques, as well as the initial AHP framework. Through this comparison and assessment of model behaviour, an evaluation of each methods predictive capacity and relevance for decision-making purposes in agricultural applications is gained.

  14. Space Trajectory Error Analysis Program (STEAP) for halo orbit missions. Volume 1: Analytic and user's manual (United States)

    Byrnes, D. V.; Carney, P. C.; Underwood, J. W.; Vogt, E. D.


    Development, test, conversion, and documentation of computer software for the mission analysis of missions to halo orbits about libration points in the earth-sun system is reported. The software consisting of two programs called NOMNAL and ERRAN is part of the Space Trajectories Error Analysis Programs (STEAP). The program NOMNAL targets a transfer trajectory from Earth on a given launch date to a specified halo orbit on a required arrival date. Either impulsive or finite thrust insertion maneuvers into halo orbit are permitted by the program. The transfer trajectory is consistent with a realistic launch profile input by the user. The second program ERRAN conducts error analyses of the targeted transfer trajectory. Measurements including range, doppler, star-planet angles, and apparent planet diameter are processed in a Kalman-Schmidt filter to determine the trajectory knowledge uncertainty. Execution errors at injection, midcourse correction and orbit insertion maneuvers are analyzed along with the navigation uncertainty to determine trajectory control uncertainties and fuel-sizing requirements. The program is also capable of generalized covariance analyses.

  15. A Comparative Analysis of Soil Metal Concentrations in Terms of Differences in Sampling and Analytical Approaches

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Ki Hyun [Sangji University, Wonju(Korea)


    To investigate the effects of inter-related factors affecting the interpretation of soil-metal concentrations, analysis of soil samples was conducted using various comparative steps. To this end, two soil sites were selected to represent both grassland and playground within a school site. Then, two study sites were investigated using 'individual grid' and 'composite' samples after being treated by two extraction methods. Results of our analysis indicated several important aspects of various factors. In general, disturbed soil site (playground) exhibited systematically enhanced metal levels in most cases than undisturbed site (grassland). However, opposite trends were also apparent for some metals including Pb, V and Zn, as their concentrations were higher in undisturbed soils, when analyzed by Korean Standard Method(KSM). The concentration patterns were more complicated, if analyzed in terms of variability within the 9 rectangular grid points of meter-by-meter intervals. Despite many differences arising from various factors involved in their analyses, computation of their arithmetic mean values were almost indistinguishable from that of their geometric mean values. The overall results of this study thus suggest that interpretation of soil-metal data should be handled with great caution. (author). 7 refs., 1 tab., 3 figs.

  16. An analytical study on performance of a diagrid structure using nonlinear static pushover analysis

    Directory of Open Access Journals (Sweden)

    Kiran Kamath


    Full Text Available In this study, an attempt has been made to study the performance characteristics of diagrid structures using nonlinear static pushover analysis. The models studied are circular in plan with aspect ratio H/B (where H is total height and B is the base width of structure varying from 2.67 to 4.26. The three different angles of external brace considered are 59°, 71° and 78° (Kim et al., 2010. The width of the base is kept constant at 12 m and height of the structure is varied accordingly. The nonlinear behaviour of the elements is modelled using plastic hinges based on moment–curvature relationship as described in FEMA 356 guidelines. Seismic response of structure in terms of base shear and roof displacement corresponding to performance point were evaluated using nonlinear static analysis and the results are compared. For 71° brace angle model base shear at performance shows an increase in all the aspect ratio considered in the study. The performance of the structure is influenced by brace angle and aspect ratio.

  17. Applying green analytical chemistry for rapid analysis of drugs: Adding health to pharmaceutical industry

    Directory of Open Access Journals (Sweden)

    Nazrul Haq


    Full Text Available Green RP-HPLC method for a rapid analysis of olmesartan medoxomil (OLM in bulk drugs, self-microemulsifying drug delivery system (SMEDDS and marketed tablets was developed and validated in the present investigation. The chromatographic identification was achieved on Lichrosphere 250 × 4.0 mm RP C8 column having a 5 μm packing as a stationary phase using a combination of green solvents ethyl acetate:ethanol (50:50% v/v as a mobile phase, at a flow rate of 1.0 mL/min with UV detection at 250 nm. The proposed method was validated for linearity, selectivity, accuracy, precision, reproducibility, robustness, sensitivity and specificity. The utility of the proposed method was verified by an assay of OLM in SMEDDS and commercial tablets. The proposed method was found to be selective, precise, reproducible, accurate, robust, sensitive and specific. The amount of OLM in SMEDDS and commercial tablets was found to be 101.25% and 98.67% respectively. The proposed method successfully resolved OLM peak in the presence of its degradation products which indicated stability-indicating property of the proposed method. These results indicated that the proposed method can be successfully employed for a routine analysis of OLM in bulk drugs and commercial formulations.

  18. Benefits and Adverse Events in Younger Versus Older Patients Receiving Neoadjuvant Chemotherapy for Osteosarcoma : Findings From a Meta-Analysis

    NARCIS (Netherlands)

    Collins, Marnie; Wilhelm, Miriam; Conyers, Rachel; Herschtal, Alan; Whelan, Jeremy; Bielack, Stefan; Kager, Leo; Kuehne, Thomas; Sydes, Matthew; Gelderblom, Hans; Ferrari, Stefano; Picci, Piero; Smeland, Sigbjorn; Eriksson, Mikael; Petrilli, Antonio Sergio; Bleyer, Archie; Thomas, David M.


    Purpose The LIVESTRONG Young Adult Alliance has conducted a meta-analysis of individual patient data from prospective neoadjuvant chemotherapy osteosarcoma studies and registries to examine the relationships of sex, age, and toxicity on survival. Patients and Methods Suitable data sets were identifi

  19. Impact of analysing continuous outcomes using final values, change scores and analysis of covariance on the performance of meta-analytic methods: a simulation study. (United States)

    McKenzie, Joanne E; Herbison, G Peter; Deeks, Jonathan J


    When meta-analysing intervention effects calculated from continuous outcomes, meta-analysts often encounter few trials, with potentially a small number of participants, and a variety of trial analytical methods. It is important to know how these factors affect the performance of inverse-variance fixed and DerSimonian and Laird random effects meta-analytical methods. We examined this performance using a simulation study. Meta-analysing estimates of intervention effect from final values, change scores, ANCOVA or a random mix of the three yielded unbiased estimates of pooled intervention effect. The impact of trial analytical method on the meta-analytic performance measures was important when there was no or little heterogeneity, but was of little relevance as heterogeneity increased. On the basis of larger than nominal type I error rates and poor coverage, the inverse-variance fixed effect method should not be used when there are few small trials. When there are few small trials, random effects meta-analysis is preferable to fixed effect meta-analysis. Meta-analytic estimates need to be cautiously interpreted; type I error rates will be larger than nominal, and confidence intervals will be too narrow. Use of trial analytical methods that are more efficient in these circumstances may have the unintended consequence of further exacerbating these issues. © 2015 The Authors. Research Synthesis Methods published by John Wiley & Sons, Ltd. © 2015 The Authors. Research Synthesis Methods published by John Wiley & Sons, Ltd.

  20. Crustal structure beneath the High Lava Plains of eastern Oregon and surrounding regions from receiver function analysis (United States)

    Eagar, Kevin C.; Fouch, Matthew J.; James, David E.; Carlson, Richard W.


    We analyze teleseismic P-to-S receiver functions to image crustal structure beneath the High Lava Plains (HLP) of eastern Oregon and surrounding regions. Coverage from 206 broadband seismic stations provides the first opportunity to resolve variations in crustal composition, thickness, and heterogeneity on scales of a few km in depth and tens of km laterally across the HLP region. We utilize both H - κ stacking and a new Gaussian-weighted common conversion point stacking technique. We find crust that is ≥40 km thick beneath the Cascades, Idaho Batholith, and Owyhee Plateau and thinner (˜31 km) crust beneath the HLP and northern Great Basin. Low Poisson's ratios of ˜0.240 characterize the granitic crust beneath the Idaho Batholith, while the Owyhee Plateau exhibits values of ˜0.270, typical of average continental crust. The Owyhee Plateau is a thick simple crustal block with distinct edges at depth. The western HLP exhibits high average values of 0.304, typical for regions of widespread basaltic volcanism. Combined with other geological and geophysical observations, the areas of abnormally high Poisson's ratios (˜0.320) and low-velocity zones in the crust beneath north-central and southern Oregon are consistent with the presence of partial melt on either side of the HLP trend, suggesting a central zone where crustal melts have drained to the surface, perhaps enabled by the Brothers Fault Zone. Thicker crust and an anomalous N-S band of low Poisson's ratios (˜0.252) skirting the Steens Mountain escarpment is consistent with residuum from a midcrustal magma source of the massive flood basalts, supporting the view of extensive mafic underplating and intraplating of the crust from Cenozoic volcanism.

  1. Predictive analysis using Big data Analytics for Sensors used in Fleet Truck Monitoring System

    Directory of Open Access Journals (Sweden)

    Preethi Varsha. V


    Full Text Available The production of large amounts of data has not only been observed in web based companies but has seen entering other domains such as automation and automobile.Smart sensors and smart devices contribute to growing amounts of data that need to be processed. The outcome expected from processing is prediction for better control, clustering for more effective maintenance or improving the overall production. The potential use is to monitor machines or infrastructure such as ventilation equipment, energy meters, truck engines, tires and environmental conditions. This predictive analysis on the data can generate information like intimation for repair or replace these items even before they break; suggestion on driving patterns on various road conditions to both the driver and fleet owner. This project examines the utilization of big data technologies for truck maintenance and performance domain. The approach is based on sensor measurements with the goal of detecting specific events and patterns.

  2. Interventions to reduce sexual prejudice: a study-space analysis and meta-analytic review. (United States)

    Bartoş, Sebastian E; Berger, Israel; Hegarty, Peter


    Sexual prejudice is an important threat to the physical and mental well-being of lesbians, gay men, and bisexual people. Therefore, we reviewed the effectiveness of interventions designed to reduce such prejudice. A study-space analysis was performed on published and unpublished papers from all over the world to identify well-studied and underexplored issues. Most studies were conducted with North American undergraduates and were educational in nature. Dissertations were often innovative and well designed but were rarely published. We then performed meta-analyses on sets of comparable studies. Education, contact with gay people, and combining contact with education had a medium-size effect on several measures of sexual prejudice. The manipulation of social norms was effective in reducing antigay behavior. Other promising interventions, such as the use of entertainment media to promote tolerance, need further investigation. More research is also needed on populations other than American students, particularly groups who may have higher levels of sexual prejudice.

  3. Critical discourse analysis on the news about terrorism: An analytical study on Turkish media

    Directory of Open Access Journals (Sweden)

    Aykut Töngür


    Full Text Available Today, combating terrorism is accepted as an international issue. Turkey has struggled with this problem for years. Combating terrorism is not only a matter for the state or government to address, but nongovernmental organizations must be contribute to the process of developing strategies and policies against terrorism. Media organs may have contribution in fighting against terrorism and newspapers which can be tools to combat terrorism are the subject of this study. Three newspapers were selected as samples of this study and news reports relating to terror and terrorism in these newspapers were analyzed according to Van Dijk’s Critical Discourse Analysis. As a result of the findings of this study, it is seen that media organs are not free from biases and ruling ideology and political view effects newspapers, magazines or televisions while presenting terror news. At the end of the study, some suggestions were developed especially for the stakeholders in the fight against terrorism.

  4. Analysis of Transverse Cracking in Composite Structures. Analytical, Numerical and Experimental Investigations

    Energy Technology Data Exchange (ETDEWEB)

    Anderssen, R.


    The background for this doctoral thesis was the need of the oil industry to be able to predict the damage level and life of composite pipes. The transverse cracking phenomena in cross-ply and angle-ply structures is studied. The best approximate stress/strain field caused by transverse matrix cracks is found by using the principles of minimum potential energy. For the cross-ply laminate the stiffness degradation and the progressive damage development as a function of the crack density was predicted. The model accounts for thermal residual stresses and the results were compared to a finite element analysis. The method was also extended to model the three-dimensional transverse cracking in angle-ply filament wound pipes. A unit cell for a general cracked angle-ply filament wound pipe, consisting of two half plies of +{theta} and -{theta} orientation, was identified. An admissible displacement field consisting of unknown functions and constraints was proposed for the 3D cracked unit cell, providing the stress and strain field in every point of this structure. Fracture criteria like the Tsai-Wu and a criteria based on the linear elastic fracture mechanics were used in the application of the model. The stiffness degradation for a {+-}{theta} angle-ply structure as a function of crack density was predicted and compared to a 3D finite element analysis. The model was applied to angle-ply filament wound pipes subjected to arbitrary ratios of applied axial and hoop stress. The proposed model combined with a convenient failure criterion seems to be able to predict the onset and subsequent progressive matrix cracking. 78 refs., 46 figs., 6 tabs.

  5. Analysis of Navigation Receiver Power Control Parameters and Performance%导航接收机功率控制参数优化与性能分析

    Institute of Scientific and Technical Information of China (English)

    陈道伟; 唐小妹; 李柏渝; 王飞雪


    随着卫星导航接收机设计的越发复杂和先进,接收机功耗越来越高,对以电池供电为主的接收机来说是一个限制问题。功率控制技术是导航接收机实现低功耗行之有效的方法。对基本功率控制技术中的关键参数时间参数进行了优化分析,利用对锁相环进行暂态响应分析的方法,得出了最优的时间参数选取,同时进一步分析了功率控制对接收机性能的影响情况,为接收机在低功耗和性能之间的选择提供了参考。本文的结论可以直接指导接收机的功率控制设计。%With the design of satellite navigation receiver becomes more complex and ad-vance ,the receiver consumes much more power ,for the receivers which powered by battery it is an important limited question ,the power control technology is an efficient way to realize the lower power consumption of the receiver .This paper analyzes the key parameters of time for the basic power control technology .Utilize the analysis of PLL (PLL ,Phase lock Loop) transient response ,the basic requirement of time parameters selection is obtained ,and ana-lyzes the effect of power control on the receiver performance ,providing a reference to select betw een the receiver performance and low pow er consumption .T he conclusion of this paper could be used to guide the power control design of the receiver .

  6. Analytical Microscopy

    Energy Technology Data Exchange (ETDEWEB)


    In the Analytical Microscopy group, within the National Center for Photovoltaic's Measurements and Characterization Division, we combine two complementary areas of analytical microscopy--electron microscopy and proximal-probe techniques--and use a variety of state-of-the-art imaging and analytical tools. We also design and build custom instrumentation and develop novel techniques that provide unique capabilities for studying materials and devices. In our work, we collaborate with you to solve materials- and device-related R&D problems. This sheet summarizes the uses and features of four major tools: transmission electron microscopy, scanning electron microscopy, the dual-beam focused-ion-beam workstation, and scanning probe microscopy.

  7. Evaluation of hemoglobin performance in the assessment of iron stores in feto-maternal pairs in a high-risk population: receiver operating characteristic curve analysis

    Directory of Open Access Journals (Sweden)

    José Carlos Jaime-Pérez


    Full Text Available Objective: By applying receiver operating characteristic curve analysis, the objective of this study was to see whether hemoglobin levels reflect body iron stores in a group of pregnant women at term who, by using serum ferritin as the reference test, had a high pre-test prob- ability of having iron deficiency anemia. Likewise, we evaluated the ability of hemoglobin and maternal serum ferritin levels to predict iron deficiency anemia in newborns. Methods: Hemoglobin and serum ferritin were measured in 187 pregnant women at term belonging to a group with a high pre-test probability of iron deficiency anemia and their newborns. Women with Hb <11.0 g/dL and newborns with cord Hb <13.0 g/dL were classified as anemic. A serum ferritin <12.0 µg/L in women and a cord blood serum ferritin <35.0 µg/L were considered to reflect empty iron stores. Receiver operating characteristic curve analysis was applied to select the cut-off points that better reflected iron stores. Results: The Hb cut-off point selected by receiver operating characteristic curve analysis in women was <11.5 g/dL (sensitivity: 60.82, specificity: 53.33%, Youden Index: 0.450. Most of the newborns had normal Hb which precluded this analysis. Maternal Hb <11.0 g/dL was the cut-off point that best reflected iron deficiency anemia in newborns (sensitivity: 55.88%, specificity: 57.24%, Youden Index: 0.217. The best cut-off point of maternal serum ferritin to reflect empty iron stores in newborns was <6.0 µg/L (sensitivity: 76.47%, specificity: 31.58%, Youden Index: 0.200. Conclusion: Hemoglobin concentration performed poorly to detect iron deficiency anemia in women at term with high risk for iron deficiency and their newborns.

  8. Evaluation of hemoglobin performance in the assessment of iron stores in feto-maternal pairs in a high-risk population: receiver operating characteristic curve analysis (United States)

    Jaime-Pérez, José Carlos; García-Arellano, Gisela; Méndez-Ramírez, Nereida; González-Llano, Óscar; Gómez-Almaguer, David


    Objective By applying receiver operating characteristic curve analysis, the objective of this study was to see whether hemoglobin levels reflect body iron stores in a group of pregnant women at term who, by using serum ferritin as the reference test, had a high pre-test probability of having iron deficiency anemia. Likewise, we evaluated the ability of hemoglobin and maternal serum ferritin levels to predict iron deficiency anemia in newborns. Methods Hemoglobin and serum ferritin were measured in 187 pregnant women at term belonging to a group with a high pre-test probability of iron deficiency anemia and their newborns. Women with Hb <11.0 g/dL and newborns with cord Hb <13.0 g/dL were classified as anemic. A serum ferritin <12.0 μg/L in women and a cord blood serum ferritin <35.0 μg/L were considered to reflect empty iron stores. Receiver operating characteristic curve analysis was applied to select the cut-off points that better reflected iron stores. Results The Hb cut-off point selected by receiver operating characteristic curve analysis in women was <11.5 g/dL (sensitivity: 60.82, specificity: 53.33%, Youden Index: 0.450). Most of the newborns had normal Hb which precluded this analysis. Maternal Hb <11.0 g/dL was the cut-off point that best reflected iron deficiency anemia in newborns (sensitivity: 55.88%, specificity: 57.24%, Youden Index: 0.217). The best cut-off point of maternal serum ferritin to reflect empty iron stores in newborns was <6.0 μg/L (sensitivity: 76.47%, specificity: 31.58%, Youden Index: 0.200). Conclusion Hemoglobin concentration performed poorly to detect iron deficiency anemia in women at term with high risk for iron deficiency and their newborns. PMID:26041420

  9. Mechanisms and mediation in survival analysis: towards an integrated analytical framework

    Directory of Open Access Journals (Sweden)

    Jonathan Pratschke


    Full Text Available Abstract Background A wide-ranging debate has taken place in recent years on mediation analysis and causal modelling, raising profound theoretical, philosophical and methodological questions. The authors build on the results of these discussions to work towards an integrated approach to the analysis of research questions that situate survival outcomes in relation to complex causal pathways with multiple mediators. The background to this contribution is the increasingly urgent need for policy-relevant research on the nature of inequalities in health and healthcare. Methods The authors begin by summarising debates on causal inference, mediated effects and statistical models, showing that these three strands of research have powerful synergies. They review a range of approaches which seek to extend existing survival models to obtain valid estimates of mediation effects. They then argue for an alternative strategy, which involves integrating survival outcomes within Structural Equation Models via the discrete-time survival model. This approach can provide an integrated framework for studying mediation effects in relation to survival outcomes, an issue of great relevance in applied health research. The authors provide an example of how these techniques can be used to explore whether the social class position of patients has a significant indirect effect on the hazard of death from colon cancer. Results The results suggest that the indirect effects of social class on survival are substantial and negative (-0.23 overall. In addition to the substantial direct effect of this variable (-0.60, its indirect effects account for more than one quarter of the total effect. The two main pathways for this indirect effect, via emergency admission (-0.12, on the one hand, and hospital caseload, on the other, (-0.10 are of similar size. Conclusions The discrete-time survival model provides an attractive way of integrating time-to-event data within the field of

  10. High throughput LC-MS/MS method for the simultaneous analysis of multiple vitamin D analytes in serum. (United States)

    Jenkinson, Carl; Taylor, Angela E; Hassan-Smith, Zaki K; Adams, John S; Stewart, Paul M; Hewison, Martin; Keevil, Brian G


    Recent studies suggest that vitamin D-deficiency is linked to increased risk of common human health problems. To define vitamin D 'status' most routine analytical methods quantify one particular vitamin D metabolite, 25-hydroxyvitamin D3 (25OHD3). However, vitamin D is characterized by complex metabolic pathways, and simultaneous measurement of multiple vitamin D metabolites may provide a more accurate interpretation of vitamin D status. To address this we developed a high-throughput liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to analyse multiple vitamin D analytes, with particular emphasis on the separation of epimer metabolites. A supportive liquid-liquid extraction (SLE) and LC-MS/MS method was developed to quantify 10 vitamin D metabolites as well as separation of an interfering 7α-hydroxy-4-cholesten-3-one (7αC4) isobar (precursor of bile acid), and validated by analysis of human serum samples. In a cohort of 116 healthy subjects, circulating concentrations of 25-hydroxyvitamin D3 (25OHD3), 3-epi-25-hydroxyvitamin D3 (3-epi-25OHD3), 24,25-dihydroxyvitamin D3 (24R,25(OH)2D3), 1,25-dihydroxyvitamin D3 (1α,25(OH)2D3), and 25-hydroxyvitamin D2 (25OHD2) were quantifiable using 220μL of serum, with 25OHD3 and 24R,25(OH)2D3 showing significant seasonal variations. This high-throughput LC-MS/MS method provides a novel strategy for assessing the impact of vitamin D on human health and disease.

  11. Radionuclide migration through fractured rock for arbitrary-length decay chain: Analytical solution and global sensitivity analysis (United States)

    Shahkarami, Pirouz; Liu, Longcheng; Moreno, Luis; Neretnieks, Ivars


    This study presents an analytical approach to simulate nuclide migration through a channel in a fracture accounting for an arbitrary-length decay chain. The nuclides are retarded as they diffuse in the porous rock matrix and stagnant zones in the fracture. The Laplace transform and similarity transform techniques are applied to solve the model. The analytical solution to the nuclide concentrations at the fracture outlet is governed by nine parameters representing different mechanisms acting on nuclide transport through a fracture, including diffusion into the rock matrices, diffusion into the stagnant water zone, chain decay and hydrodynamic dispersion. Furthermore, to assess how sensitive the results are to parameter uncertainties, the Sobol method is applied in variance-based global sensitivity analyses of the model output. The Sobol indices show how uncertainty in the model output is apportioned to the uncertainty in the model input. This method takes into account both direct effects and interaction effects between input parameters. The simulation results suggest that in the case of pulse injections, ignoring the effect of a stagnant water zone can lead to significant errors in the time of first arrival and the peak value of the nuclides. Likewise, neglecting the parent and modeling its daughter as a single stable species can result in a significant overestimation of the peak value of the daughter nuclide. It is also found that as the dispersion increases, the early arrival time and the peak time of the daughter decrease while the peak value increases. More importantly, the global sensitivity analysis reveals that for time periods greater than a few thousand years, the uncertainty of the model output is more sensitive to the values of the individual parameters than to the interaction between them. Moreover, if one tries to evaluate the true values of the input parameters at the same cost and effort, the determination of priorities should follow a certain

  12. Asaia bogorensis peritonitis identified by 16S ribosomal RNA sequence analysis in a patient receiving peritoneal dialysis. (United States)

    Snyder, Richard W; Ruhe, Jorg; Kobrin, Sidney; Wasserstein, Alan; Doline, Christa; Nachamkin, Irving; Lipschutz, Joshua H


    Here the authors report a case of refractory peritonitis leading to multiple hospitalizations and the loss of peritoneal dialysis access in a patient on automated peritoneal dialysis, caused by Asaia bogorensis, a bacterium not previously described as a human pathogen. This organism was identified by sequence analysis of the 16S ribosomal RNA gene. Unusual microbial agents may cause peritonitis, and molecular microbiological techniques are important tools for identifying these agents.

  13. Analytical quadrics

    CERN Document Server

    Spain, Barry; Ulam, S; Stark, M


    Analytical Quadrics focuses on the analytical geometry of three dimensions. The book first discusses the theory of the plane, sphere, cone, cylinder, straight line, and central quadrics in their standard forms. The idea of the plane at infinity is introduced through the homogenous Cartesian coordinates and applied to the nature of the intersection of three planes and to the circular sections of quadrics. The text also focuses on paraboloid, including polar properties, center of a section, axes of plane section, and generators of hyperbolic paraboloid. The book also touches on homogenous coordi

  14. Application of novel analytical ultracentrifuge analysis to solutions of fungal mannans

    KAUST Repository

    Gillis, Richard B.


    Polysaccharides, the most abundant biopolymers, are required for a host of activities in lower organisms, animals, and plants. Their solution characterization is challenging due to their complex shape, heterogeneity, and size. Here, recently developed data analysis approaches were applied for traditional sedimentation equilibrium and velocity methods in order to investigate the molar mass distribution(s) of a subtype of polysaccharide, namely, mannans from four Candida spp. The molecular weight distributions of these mannans were studied using two recently developed equilibrium approaches: SEDFIT-MSTAR and MULTISIG, resulting in corroboratory distribution profiles. Additionally, sedimentation velocity data for all four mannans, analyzed using ls-g*(s) and Extended Fujita approaches, suggest that two of the fungal mannans (FM-1 and FM-3) have a unimodal distribution of molecular species whereas two others (FM-2 and FM-4) displayed bi-modal and broad distributions, respectively: this demonstrates considerable molecular heterogeneity in these polysaccharides, consistent with previous observations of mannans and polysaccharides in general. These methods not only have applications for the characterization of mannans but for other biopolymers such as polysaccharides, DNA, and proteins (including intrinsically disordered proteins).

  15. A novel four-dimensional analytical approach for analysis of complex samples. (United States)

    Stephan, Susanne; Jakob, Cornelia; Hippler, Jörg; Schmitz, Oliver J


    A two-dimensional LC (2D-LC) method, based on the work of Erni and Frei in 1978, was developed and coupled to an ion mobility-high-resolution mass spectrometer (IM-MS), which enabled the separation of complex samples in four dimensions (2D-LC, ion mobility spectrometry (IMS), and mass spectrometry (MS)). This approach works as a continuous multiheart-cutting LC system, using a long modulation time of 4 min, which allows the complete transfer of most of the first - dimension peaks to the second - dimension column without fractionation, in comparison to comprehensive two-dimensional liquid chromatography. Hence, each compound delivers only one peak in the second dimension, which simplifies the data handling even when ion mobility spectrometry as a third and mass spectrometry as a fourth dimension are introduced. The analysis of a plant extract from Ginkgo biloba shows the separation power of this four-dimensional separation method with a calculated total peak capacity of more than 8700. Furthermore, the advantage of ion mobility for characterizing unknown compounds by their collision cross section (CCS) and accurate mass in a non-target approach is shown for different matrices like plant extracts and coffee. Graphical abstract Principle of the four-dimensional separation.

  16. Spectrophotometric investigation of famotidine-Pd(II complex and its analytical application in drug analysis

    Directory of Open Access Journals (Sweden)



    Full Text Available By using different spectrophotometric methods, it was found that famotidine and palladium(II ions form a complex, Pd(II : famotidine = 1:1, which has an absorption maximum at 345 nm. The formation of the complex between famotidine and palladium(II chloride in Britton–Robinson buffer solution in the pH range 2.23–8.50 was studied. The conditional stability constant of the complex at the optimum pH 2.62 and ionic strength 0.5 M was found to be log K’ = 3.742 ± 0.025. The Beer’s law was verified over the famotidine concentration range from 5×10-5 – 6×10-4 M. The proposed method was found to be suitable for accurate and sensitive analysis of famotidine both as the substance (RSD = 1.02–1.80 % and its dosage forms (RSD = 1.75–1.83 %.

  17. Analytic stability analysis of three-component self-regulatory genetic circuit

    CERN Document Server

    Lee, Julian


    A self-regulatory genetic circuit, where a protein acts as a positive regulator of its own production, is known to be a simplest form of biological network with a positive feedback loop. Although at least three components, DNA, RNA, and the protein, are required to form such a circuit, the stability analysis of fixed points of the self-regulatory circuit has been performed only after reducing the system into to a two-component system consisting of RNA and protein only, assuming a fast equilibration of the DNA component. Here, the stability of fixed points of the three-component positive feedback loop is analyzed by obtaining eigenvalues of full three dimensional Hessian matrix. In addition to rigorously identifying the stable fixed points and the saddle points, detailed information can be obtained, such as the number of positive eigenvalues near a saddle point. In particular, complex eigenvalues is shown to exist for sufficiently slow binding and unbinding of the auto-regulatory transcription factor to DNA, l...

  18. Analytical development of disturbed matrix eigenvalue problem applied to mixed convection stability analysis in Darcy media (United States)

    Hamed, Haikel Ben; Bennacer, Rachid


    This work consists in evaluating algebraically and numerically the influence of a disturbance on the spectral values of a diagonalizable matrix. Thus, two approaches will be possible; to use the theorem of disturbances of a matrix depending on a parameter, due to Lidskii and primarily based on the structure of Jordan of the no disturbed matrix. The second approach consists in factorizing the matrix system, and then carrying out a numerical calculation of the roots of the disturbances matrix characteristic polynomial. This problem can be a standard model in the equations of the continuous media mechanics. During this work, we chose to use the second approach and in order to illustrate the application, we choose the Rayleigh-Bénard problem in Darcy media, disturbed by a filtering through flow. The matrix form of the problem is calculated starting from a linear stability analysis by a finite elements method. We show that it is possible to break up the general phenomenon into other elementary ones described respectively by a disturbed matrix and a disturbance. A good agreement between the two methods was seen. To cite this article: H.B. Hamed, R. Bennacer, C. R. Mecanique 336 (2008).


    Directory of Open Access Journals (Sweden)

    Bárbara G. Amado


    Full Text Available The credibility of a testimony is a crucial component of judicial decision-making. Checklists of testimony credibility criteria are extensively used by forensic psychologists to assess the credibility of a testimony, and in many countries they are admitted as valid scientific evidence in a court of law. These checklists are based on the Undeutsch hypothesis asserting that statements derived from the memory of real-life experiences differ significantly in content and quality from fabricated or fictitious accounts. Notwithstanding, there is considerable controversy regarding the degree to which these checklists comply with the legal standards for scientific evidence to be admitted in a court of law (e.g., Daubert standards. In several countries, these checklists are not admitted as valid evidence in court, particularly in view of the inconsistent results reported in the scientific literature. Bearing in mind these issues, a meta-analysis was designed to test the Undeutsch hypothesis using the CBCA Checklist of criteria to discern between memories of self-experienced real-life events and fabricated or fictitious accounts. As the original hypothesis was formulated for populations of children, only quantitative studies with samples of children were considered for this study. In line with the Undeutsch hypothesis, the results showed a significant positive effect size that is generalizable to the total CBCA score, δ = 0.79. Moreover, a significant positive effect size was observed in each and all of the credibility criteria. In conclusion, the results corroborated the validity of the Undeutsch hypothesis and the CBCA criteria for discriminating between the memory of real self-experienced events and false or invented accounts. The results are discussed in terms of the implications for forensic practice. Con frecuencia, la evaluación de la fiabilidad de un testimonio se lleva a cabo mediante el uso de sistemas categoriales de análisis de contenido

  20. Proteomic analysis of synovial fluid as an analytical tool to detect candidate biomarkers for knee osteoarthritis. (United States)

    Liao, Weixiong; Li, Zhongli; Zhang, Hao; Li, Ji; Wang, Ketao; Yang, Yimeng


    We conducted research to detect the proteomic profiles in synovial fluid (SF) from knee osteoarthritis (OA) patients to better understand the pathogenesis and aetiology of OA. Our long-term goal is to identify reliable candidate biomarkers for OA in SF. The SF proteins obtained from 10 knee OA patients and 10 non-OA patients (9 of whom were patients with a meniscus injury in the knee; 1 had a discoid meniscus in the knee, and all exhibited intact articular cartilage) were separated by two-dimensional electrophoresis (2-DE). The repeatability of the obtained protein spots regarding their intensity was tested via triplicate 2-DE of selected samples. The observed protein expression patterns were subjected to statistical analysis, and differentially expressed protein spots were identified via matrix-assisted laser desorption/ionisation-time of flight/time of flight mass spectrometry (MALDI-TOF/TOF MS). Our analyses showed low intrasample variability and clear intersample variation. Among the protein spots observed on the gels, there were 29 significant differences, of which 22 corresponded to upregulation and 7 to downregulation in the OA group. One of the upregulated protein spots was confirmed to be haptoglobin by mass spectrometry, and the levels of haptoglobin in SF are positively correlated with the severity of OA (r = 0.89, P < 0.001). This study showed that 2-DE could be used under standard conditions to screen SF samples and identify a small subset of proteins in SF that are potential markers associated with OA. Spots of interest identified by mass spectrometry, such as haptoglobin, may be associated with OA severity.

  1. Criteria-Based Content Analysis (CBCA reality criteria in adults: A meta-analytic review

    Directory of Open Access Journals (Sweden)

    Bárbara G. Amado


    Full Text Available Antecedentes/Objetivo: El Criteria-Based Content Analysis (CBCA constituye la herramienta mundialmente más utilizada para la evaluación de la credibilidad del testimonio. Originalmente fue creado para testimonios de menores víctimas de abuso sexual, gozando de amparo científico. Sin embargo, se ha generalizado su práctica a poblaciones de adultos y otros contextos sin un aval de la literatura para tal generalización. Método: Por ello, nos planteamos una revisión meta-analítica con el objetivo de contrastar la Hipótesis Undeutsch y los criterios de realidad del CBCA para conocer su potencial capacidad discriminativa entre memorias de eventos auto-experimentados y fabricados en adultos. Resultados: Los resultados confirman la hipótesis Undeutsch y validan el CBCA como técnica. No obstante, los resultados no son generalizables y los criterios auto-desaprobación y perdón al autor del delito no discriminan entre ambas memorias. Además, se encontró que la técnica puede ser complementada con criterios adicionales de realidad. El estudio de moderadores mostró que la eficacia discriminativa era significativamente superior en estudios de campo en casos de violencia sexual y de género. Conclusiones: Se discute la utilidad, así como las limitaciones y condiciones para la transferencia de estos resultados a la práctica forense.

  2. Disaster risk management in prospect mining area Blitar district, East Java, using microtremor analysis and ANP (analytical network processing) approach

    Energy Technology Data Exchange (ETDEWEB)

    Parwatiningtyas, Diyan, E-mail:, E-mail:; Ambarsari, Erlin Windia, E-mail:, E-mail:; Marlina, Dwi, E-mail:, E-mail:; Wiratomo, Yogi, E-mail:, E-mail: [Department of Physics, Faculty of Engineering, Mathematics and Natural Sciences, Indraprasta PGRI University, Nangka Street No. 58C Tanjung Barat, South Jakarta (Indonesia)


    Indonesia has a wealth of natural assets is so large to be managed and utilized, either from its own local government and local communities, especially in the mining sector. However, mining activities can change the state of the surface layer of the earth that have a high impact disaster risk. This could threaten the safety and disrupt human life, environmental damage, loss of property, and the psychological impact, sulking to the rule of law no 24 of 2007. That's why we strive to manage and minimize the risk of mine disasters in the region, how to use the method of calculation of Amplification Factor (AF) from the analysis based microtremor sulking Kanai and Nakamura, and decision systems were tested by analysis of ANP. Based on the amplification factor and Analytical Network Processing (ANP) obtained, some points showed instability in the surface layer of a mining area include the site of the TP-7, TP-8, TP-9, TP-10, (Birowo2). If in terms of structure, location indicated unstable due to have a sloping surface layer, resulting in the occurrence of landslides and earthquake risk is high. In the meantime, other areas of the mine site can be said to be a stable area.

  3. Double-sided Microfluidic Device for Speciation Analysis of Iron in Water Samples: Towards Greener Analytical Chemistry. (United States)

    Youngvises, Napaporn; Thanurak, Porapichcha; Chaida, Thanatcha; Jukmunee, Jaroon; Alsuhaimi, Awadh


    Microfluidics minimize the amounts of reagents and generate less waste. While microdevices are commonly single-sided, producing a substrate with microchannels on multiple surfaces would increase their usefulness. Herein, a polymethymethacrylate substrate incorporating microchannel structures on two sides was sandwiched between two polydimethylsiloxane sheets to create a multi-analysis device, which was used for the spectrophotometric analysis of the ferrous ion (Fe(2+)) and the ferric ion (Fe(3+)), by utilizing colorimetric detection. To monitor the signals from both channel networks, dual optical sensors were integrated into the system. The linear ranges for Fe(2+) and Fe(3+) analyses were 0.1 - 20 mg L(-1) (R(2) = 0.9988) and 1.0 - 40 mg L(-1) (R(2) = 0.9974), respectively. The detection limits for Fe(2+) and Fe(3+) were 0.1 and 0.5 mg L(-1), respectively. The percent recoveries of Fe(2+) and Fe(3+) were 93.5 - 104.3 with an RSD analytical chemistry applications.

  4. Disaster risk management in prospect mining area Blitar district, East Java, using microtremor analysis and ANP (analytical network processing) approach (United States)

    Parwatiningtyas, Diyan; Ambarsari, Erlin Windia; Marlina, Dwi; Wiratomo, Yogi


    Indonesia has a wealth of natural assets is so large to be managed and utilized, either from its own local government and local communities, especially in the mining sector. However, mining activities can change the state of the surface layer of the earth that have a high impact disaster risk. This could threaten the safety and disrupt human life, environmental damage, loss of property, and the psychological impact, sulking to the rule of law no 24 of 2007. That's why we strive to manage and minimize the risk of mine disasters in the region, how to use the method of calculation of Amplification Factor (AF) from the analysis based microtremor sulking Kanai and Nakamura, and decision systems were tested by analysis of ANP. Based on the amplification factor and Analytical Network Processing (ANP) obtained, some points showed instability in the surface layer of a mining area include the site of the TP-7, TP-8, TP-9, TP-10, (Birowo2). If in terms of structure, location indicated unstable due to have a sloping surface layer, resulting in the occurrence of landslides and earthquake risk is high. In the meantime, other areas of the mine site can be said to be a stable area.

  5. The prognostic role of BRAF mutation in metastatic colorectal cancer receiving anti-EGFR monoclonal antibodies: a meta-analysis.

    Directory of Open Access Journals (Sweden)

    Zi-Xu Yuan

    Full Text Available BACKGROUND: BRAF mutation has been investigated as a prognostic factor in metastatic colorectal cancer (mCRC undergoing anti-EGFR monoclonal antibodies (moAbs, but current results are still inconclusive. The aim of this meta-analysis was to evaluate the relationship between BRAF mutation status and the prognosis of mCRC patients treated with moAbs. METHODS: Eligible studies were identified by systematically searching Pubmed, the Cochrane Library, Web of Knowledge, and OVID. Risk ratio (RR for overall response rate (ORR, Hazard ratios (HRs for Progression free survival (PFS and Overall survival (OS were extracted or calculated. Prespecified subgroup analyses were conducted in KRAS wild-type and in different study types. The source of between-trial variation was explored by sensitivity analyses. Quality assessment was conducted by the Hayden's criteria. RESULTS: A total of twenty one trials including 5229 patients were identified for the meta-analysis. 343 patients displayed BRAF mutations of 4616 (7.4% patients with known BRAF status. Patients with BRAF wild-type (WT showed decreased risks of progression and death with an improved PFS(HR 0.38, 95% confidence intervals 0.29-0.51 and an improved OS (HR 0.35 [0.29-0.42], compared to BRAF mutant. In KRAS WT population, there were even larger PFS benefit (HR 0.29[0.19,0.43] and larger OS benefit (HR 0.26 [0.20,0.35] in BRAF WT. A response benefit for BRAF WT was observed (RR 0.31[0.18,0.53] in KRAS WT patients, but not observed in unselected patients (RR 0.76 [0.43-1.33]. The results were consistent in the subgroup analysis of different study types. Heterogeneity between trials decreased in the subgroup and explained by sensitivity analysis. No publication bias of ORR, PFS and OS were detected. CONCLUSIONS: The results indicate that BRAF mutant is a predictive biomarker for poor prognosis in mCRC patients undergoing anti-EGFR MoAbs therapy, especially in KRAS WT patients. Additional large prospective

  6. Analytical Chemistry Laboratory (United States)

    Anderson, Mark


    The Analytical Chemistry and Material Development Group maintains a capability in chemical analysis, materials R&D failure analysis and contamination control. The uniquely qualified staff and facility support the needs of flight projects, science instrument development and various technical tasks, as well as Cal Tech.

  7. Game Analytics

    DEFF Research Database (Denmark)

    Seif El-Nasr, Magy; Drachen, Anders; Canossa, Alessandro


    Game Analytics has gained a tremendous amount of attention in game development and game research in recent years. The widespread adoption of data-driven business intelligence practices at operational, tactical and strategic levels in the game industry, combined with the integration of quantitative...

  8. A superconducting tunnel junction receiver for submillimeter astronomy, and analysis of observations of post-AGB star molecular envelopes. [AGB (asymptotic giant branch)

    Energy Technology Data Exchange (ETDEWEB)

    Jaminet, P.A.


    A heterodyne receiver designed for astronomical use between 450 and 520 GHz has been constructed. Very low capacitance (C [approximately] 5-10 fF) Superconductor-Insulator-Superconductor (SIS) junctions have been fabricated as the detectors; these junctions lie on the edges of niobium thin films and form Nb-Al-Al[sub 2]O[sub 3]-Al-Nb sandwiches. The double sideband (DSB) receiver noise temperature is between 400 K and 800 K throughout the 70 GHz band. In addition, detailed modelling and analysis of astronomical observations of two post-AGB (Asymptotic Giant Branch) stars was performed. The observations were made with an SIS receiver designed for 345 GHz. CO observations and modelling of the young planetary nebula NGC 7027 provided the best determination yet of its AGB mass loss rate, the first direct evidence for bipolarity in its AGB mass loss, evidence for close hydrodynamic coupling between the planetary nebula and the relic AGB wind, and evidence for evolution in the metallicity of the stellar wind. Observations of the proto-planetary nebula CRL 2688 found evidence for spatially extended fast wind emission with a non-bipolar morphology, and evidence for evolution is elemental abundances in the stellar wind.

  9. Diagnostic Accuracy of Computer based Tests for Attention-Deficit Hyperactivity Disorder: A Receiver-Operating Characteristic Analysis

    Directory of Open Access Journals (Sweden)

    Thomas Dreisörner


    Full Text Available Objectives: Attention-Deficit Hyperactivity Disorder (ADHD is one of the most common neurobehavioral diagnosis affecting children today. Guidelines of child psychiatry encourage clinicians to employ clinical interviews and questionnaires, learning and performance tests and behavior observation in making the diagnosis. Special attention tests can be conducted additionally. Computer-based attention tests constitute a promising method to do so as they appeal to children. In clinical practise in Germany two test batteries are commonly used: “Testbatterie zur Aufmerksamkeitsprüfung” (TAP and “Testbatterie zur Aufmerksamkeitsprüfung für Kinder” (KITAP. The latter having been adapted to the motivational needs of children. This study aims at examining the diagnostic accuracy of the TAP and KITAP. Methods: ROC-analysis of TAP- and KITAP parameters and logistic regressions were conducted in a sample of 24 children with and without ADHD. Results: Both TAP and KITAP proved to differentiate between children with and without ADHD. TAP parameters possessed a higher discriminating power for ADHD. In logistic regression analysis TAP parameters led to an amount of variance of 32.5% (KITAP: 21.6% and correct classification rate of 75% (KITAP: 72.9%. Adding KITAP parameters did not improve the amount of variance significantly whereas adding TAP parameters to the KITAP data did result in a significant increase. Conclusion: These findings suggest that TAP and KITAP could serve as useful additional test instruments to help identify cases likely to meet criteria for ADHD in clinical settings. For individual diagnosis TAP and KITAP lack cut-off criteria and substantial classification rates.

  10. [Analysis of proposals received and funded in discipline of microbiology of the National Natural Science Foundation of China from 2011 to 2015]. (United States)

    Zhang, Xin; Li, Weimin; He, Jianwei; Wen, Mingzhang; Du, Quansheng


    Based on a wrap-up of the research proposals received and awards made during 2011 through 2015 in the discipline of microbiology of the Department of Life Sciences, National Natural Science Foundation of China, this article presents a statistic analysis of award recipient institutions and main research trends, and attempts a prospective prioritization of the funding areas from the points of encouraging interdisciplinary research, optimizing funding instruments and strengthening talent training, with a view to providing reference for scientists and researchers in the field of microbiology.


    Directory of Open Access Journals (Sweden)

    Harumi Aini


    Full Text Available Cocoa is one of the plantation commodities whose role is quite important for the national economy of Indonesia. However, the cocoa industry faces several problems including the various risks involved in the cocoa supply chain. The aim of this study were: 1 Identify the various risks involved in the cocoa supply chain, 2 analyze and evaluate the supply chain actors members with the highest risk in the cocoa supply chain management, and 3 understand how to evaluate and mitigate the highest risk in the cocoa supply chain effectively and efficiently. An Integrated Analytic Network Process (ANP and Weighted Failure Mode Effect Analysis (WFMEA method will be used to determine and analyze the highest risk in the cocoa supply chain. The results of the priority of the members of the value chain in the cocoa supply chain risk management are the farmer (0.408 with the risk of having the greatest priority is production risk (0.221. Risk control could be done by improving the productivity and competitiveness of cocoa.Keywords: ANP, FMEA, cocoa, risk management, supply chainABSTRAKKakao merupakan salah satu komoditas perkebunan yang peranannya cukup penting bagi perekonomian Indonesia. Industri kakao menghadapi beberapa masalah termasuk berbagai risiko yang timbul dalam rantai pasokan kakao. Tujuan penelitian ini adalah 1 mengidentifikasi macam-macam risiko pada rantai pasok kakao, 2 menganalisis dan mengevaluasi anggota pelaku rantai pasok dengan risiko tertinggi dalam manajemen rantai pasok kakao, dan 3 mengetahui cara mengevaluasi dan memitigasi risiko tertinggi pada rantai pasok kakao dengan efektif dan efisien. Metode Analytic Network Process (ANP dan Weighted Failure Mode Effect Analysis (WFMEA terintegrasi digunakan untuk mengetahui dan menganalisis risiko tertinggi dalam rantai pasokan kakao. Hasil prioritas anggota pelaku rantai pasok dalam manajemen risiko rantai pasokan kakao petani (0,408 dengan risiko yang memiliki prioritas terbesar adalah

  12. Single-frequency, dual-GNSS versus dual-frequency, single-GNSS: a low-cost and high-grade receivers GPS-BDS RTK analysis (United States)

    Odolinski, Robert; Teunissen, Peter J. G.


    The concept of single-frequency, dual-system (SF-DS) real-time kinematic (RTK) positioning has become feasible since, for instance, the Chinese BeiDou Navigation Satellite System (BDS) has become operational in the Asia-Pacific region. The goal of the present contribution is to investigate the single-epoch RTK performance of such a dual-system and compare it to a dual-frequency, single-system (DF-SS). As the SF-DS we investigate the L1 GPS + B1 BDS model, and for DF-SS we take L1, L2 GPS and B1, B2 BDS, respectively. Two different locations in the Asia-Pacific region are analysed with varying visibility of the BDS constellation, namely Perth in Australia and Dunedin in New Zealand. To emphasize the benefits of such a model we also look into using low-cost ublox single-frequency receivers and compare such SF-DS RTK performance to that of a DF-SS, based on much more expensive survey-grade receivers. In this contribution a formal and empirical analysis is given. It will be shown that with the SF-DS higher elevation cut-off angles than the conventional 10° or 15° can be used. The experiment with low-cost receivers for the SF-DS reveals (for the first time) that it has the potential to achieve comparable ambiguity resolution performance to that of a DF-SS (L1, L2 GPS), based on the survey-grade receivers.

  13. Assessing the predictive performance of risk-based water quality criteria using decision error estimates from receiver operating characteristics (ROC) analysis. (United States)

    McLaughlin, Douglas B


    Field data relating aquatic ecosystem responses with water quality constituents that are potential ecosystem stressors are being used increasingly in the United States in the derivation of water quality criteria to protect aquatic life. In light of this trend, there is a need for transparent quantitative methods to assess the performance of models that predict ecological conditions using a stressor-response relationship, a response variable threshold, and a stressor variable criterion. Analysis of receiver operating characteristics (ROC analysis) has a considerable history of successful use in medical diagnostic, industrial, and other fields for similarly structured decision problems, but its use for informing water quality management decisions involving risk-based environmental criteria is less common. In this article, ROC analysis is used to evaluate predictions of ecological response variable status for 3 water quality stressor-response data sets. Information on error rates is emphasized due in part to their common use in environmental studies to describe uncertainty. One data set is comprised of simulated data, and 2 involve field measurements described previously in the literature. These data sets are also analyzed using linear regression and conditional probability analysis for comparison. Results indicate that of the methods studied, ROC analysis provides the most comprehensive characterization of prediction error rates including false positive, false negative, positive predictive, and negative predictive errors. This information may be used along with other data analysis procedures to set quality objectives for and assess the predictive performance of risk-based criteria to support water quality management decisions.

  14. Complex Analysis of Askaryan Radiation: A Fully Analytic Treatment including the LPM effect and Cascade Form Factor

    CERN Document Server

    Hanson, Jordan C


    The Askaryan effect describes coherent electromagnetic radiation from the collective charge within high-energy cascades in dense media. We present the first fully analytic model of Askaryan radiation that accounts simultaneously for the three-dimensional form factor of the electromagnetic cascade and the Landau-Pomeranchuk-Migdal (LPM) effect. Analytic calculations avoid computationally intensive Monte Carlo simulations of the cascades. Searches for cosmogenic neutrinos in Askaryan- based detectors benefit from computational speed, because neutrino event parameters affect the shape of the electromagnetic field, requiring scans of parameter space. The Askaryan field is derived and verified against Geant4 simulations, and compared with prior numerical and semi-analytic calculations. Finally, two special cases of the model are transformed from the Fourier domain to the time-domain, analytically. Next-generation in situ detectors like ARA and ARIANNA can use analytic time-domain signal models to search for phase ...

  15. Effect of noninvasive positive pressure ventilation on weaning success in patients receiving invasive mechanical ventilation: a meta-analysis

    Institute of Scientific and Technical Information of China (English)

    ZHU Fen; LIU Zi-long; LONG Xuan; WU Xiao-dan; ZHOU Jing; BAI Chun-xue; LI Shan-qun


    Background Noninvasive positive pressure ventilation (NIPPV) has been proposed to shorten the duration of mechanical ventilation in intubated patients,especially those who fail initial weaning from invasive mechanical ventilation (IMV).However,there are also some discrepancies in terms of weaning success or failure,incidence of re-intubation,complications observed during study and patient outcomes.The primary objective of this update was to specifically investigate the role of NIPPV on facilitating weaning and avoiding re-intubation in patients intubated for different etiologies of acute respiratory failure,by comparing with conventional invasive weaning approach.Methods We searched randomized controlled trials (RCTs) comparing noninvasive weaning of early extubation and immediate application of NIPPV with invasive weaning in intubated patients from PubMed,Embase,Cochrane Central Register of Controlled Trials,Web of Knowledge and Springerlink databases.Records from conference proceedings and reference lists of relevant studies were also identified.Results A total of 11 RCTs with 623 patients were available for the present analysis.Compared with IMV,NIPPV significantly increased weaning success rates (odds ratio (OR):2.50,95% confidence interval (C/):1.46-4.30,P=0.0009),decreased mortality (OR:0.39,95% CI:0.20-0.75,P=0.005),and reduced the incidence of ventilator associated pneumonia (VAP) (OR:0.17,95% CI:0.08-0.37,P <0.00001) and complications (OR:0.22,95% CI:0.07-0.72,P=0.01).However,effect of NIPPV on re-intubation did not reach statistical difference (OR:0.61,95% CI:0.33-1.11,P=0.11).Conclusions Early extubation and immediate application of NIPPV is superior to conventional invasive weaning approach in increasing weaning success rates,decreasing the risk of mortality and reducing the incidence of VAP and complications,in patients who need weaning from IMV.However,it should be applied with caution,as there is insufficient beneficial evidence to

  16. Combined approach of grey relational analysis and analytic hierarchy process for ARCAL/IAEA strategic actions prioritization

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Pedro Maffia da; Martins, Eduardo Ferraz; Rondinelli Junior, Francisco, E-mail:, E-mail:, E-mail: [Comissao Nacional de Energia Nuclear (CNEN), Rio de Janeiro, RJ (Brazil); Garcia, Pauli Adriano de Almada, E-mail: [Universidade Federal Fluminense (UFF), Volta Redonda, RJ (Brazil)


    The IAEA technical cooperation (TC) programme is the main mechanism through which the IAEA delivers technical services to its Member States. Through the programme, the IAEA helps Member States to build, strengthen and maintain capacities in the safe, peaceful and secure use of nuclear technology in support of sustainable socioeconomic development. The Regional Cooperation Agreement for the Promotion of Nuclear Science and Technology in Latin America and the Caribbean (ARCAL) is a TC agreement between most IAEA member states in the Latin America and the Caribbean region for technical and economic cooperation to promote the use of nuclear techniques for peace and development. The present study aims to propose a combined approach to prioritize the needs and problems of ARCAL region. To do that, this paper considers the concept of Grey Relational Analysis and Analytic Hierarchy Process for data treatment, standardization and ranking of those needs and problems. In other words, the proposition intend to reduce the biases that may be introduced along the stage of the needs and problems assessment in the regional strategic profile formulation. (author)

  17. On the propagation of concentration polarization from microchannel-nanochannel interfaces. Part I: Analytical model and characteristic analysis. (United States)

    Mani, Ali; Zangle, Thomas A; Santiago, Juan G


    We develop two models to describe ion transport in variable-height micro- and nanochannels. For the first model, we obtain a one-dimensional (unsteady) partial differential equation governing flow and charge transport through a shallow and wide electrokinetic channel. In this model, the effects of electric double layer (EDL) on axial transport are taken into account using exact solutions of the Poisson-Boltzmann equation. The second simpler model, which is approachable analytically, assumes that the EDLs are confined to near-wall regions. Using a characteristics analysis, we show that the latter model captures concentration polarization (CP) effects and provides useful insight into its dynamics. Two distinct CP regimes are identified: CP with propagation in which enrichment and depletion shocks propagate outward, and CP without propagation where polarization effects stay local to micro- nanochannel interfaces. The existence of each regime is found to depend on a nanochannel Dukhin number and mobility of the co-ion nondimensionalized by electroosmotic mobility. Interestingly, microchannel dimensions and axial diffusion are found to play an insignificant role in determining whether CP propagates. The steady state condition of propagating CP is shown to be controlled by channel heights, surface chemistry, and co-ion mobility instead of the reservoir condition. Both models are validated against experimental results in Part II of this two-paper series.

  18. Applying Fuzzy Analytic Hierarchy Process and Grey Relation Analysis to Evaluate the Supply Chain Performance of the Wafer Testing House

    Directory of Open Access Journals (Sweden)

    Yun-Chin Chen


    Full Text Available Problem statement: In the information age, the process of E-Commerce (EC operates quickly and the present enterprises of Taiwan have to face the Free Cross-Strait Market (FCSM with Mainland China, which will definitely change the model as well as the performance of the supply chain. Hence, this study focuses on the issue of supply chain performance evaluation of the wafer testing house in Taiwan. Approach: This investigation applied the Fuzzy Analytic Hierarchy Process (FAHP to derive the weights of influential indicators for evaluating the supply chain performance of the wafer testing house and the Grey Relation Analysis (GRA was used to evaluate the performance between the FCSM and EC aspects. Results: The analyzed results had identified the indicator weight of the supply chain performance evaluation in the wafer testing house and the indicator performances between different aspects were compared. The research results indicated that the FCSM aspect had better performance than EC aspect of the supply chain evaluation in the wafer testing house. Conclusion/Recommendations: Based on the analyzed results, the managers can find out the problems and improve the supply chain performance of the wafer testing house. This study not only can be a good basis for improvements of the case company, but also can be the reference for evaluating the supply chain performance of the wafer testing house.

  19. Effectiveness of cognitive behavioral therapy for depression in patients receiving disability benefits: a systematic review and individual patient data meta-analysis.

    Directory of Open Access Journals (Sweden)

    Shanil Ebrahim

    Full Text Available OBJECTIVES: To systematically summarize the randomized trial evidence regarding the relative effectiveness of cognitive behavioural therapy (CBT in patients with depression in receipt of disability benefits in comparison to those not receiving disability benefits. DATA SOURCES: All relevant RCTs from a database of randomized controlled and comparative studies examining the effects of psychotherapy for adult depression (, electronic databases (MEDLINE, EMBASE, PSYCINFO, AMED, CINAHL and CENTRAL to June 2011, and bibliographies of all relevant articles. STUDY ELIGIBILITY CRITERIA, PARTICIPANTS AND INTERVENTION: Adult patients with major depression, randomly assigned to CBT versus minimal/no treatment or care-as-usual. STUDY APPRAISAL AND SYNTHESIS METHODS: Three teams of reviewers, independently and in duplicate, completed title and abstract screening, full text review and data extraction. We performed an individual patient data meta-analysis to summarize data. RESULTS: Of 92 eligible trials, 70 provided author contact information; of these 56 (80% were successfully contacted to establish if they captured receipt of benefits as a baseline characteristic; 8 recorded benefit status, and 3 enrolled some patients in receipt of benefits, of which 2 provided individual patient data. Including both patients receiving and not receiving disability benefits, 2 trials (227 patients suggested a possible reduction in depression with CBT, as measured by the Beck Depression Inventory, mean difference [MD] (95% confidence interval [CI] = -2.61 (-5.28, 0.07, p = 0.06; minimally important difference of 5. The effect appeared larger, though not significantly, in those in receipt of benefits (34 patients versus not receiving benefits (193 patients; MD (95% CI = -4.46 (-12.21, 3.30, p = 0.26. CONCLUSIONS: Our data does not support the hypothesis that CBT has smaller effects in depressed patients receiving

  20. Influence of the nonlinear phase and ASE noise on DPSK balanced optical receiver in optical fiber communication system

    Institute of Scientific and Technical Information of China (English)

    李蔚; 梅君瑶; 韩庆生; 王腾


    The analytical expression of bit error probability in a balanced differential phase-shift keying(DPSK) optical receiver considering nonlinear phase noise and EDFA ASE noise is given,which is very useful to estimate the performance of DPSK balanced and unbalanced receiver in optical communication system.Through analysis,if only nonlinear phase noise is considered,both the balance and unbalanced receivers have the same performances.But if adding the ASE noise of EDFA,the balanced receiver is better.

  1. Error analysis of analytic solutions for self-excited near-symmetric rigid bodies - A numerical study (United States)

    Kia, T.; Longuski, J. M.


    Analytic error bounds are presented for the solutions of approximate models for self-excited near-symmetric rigid bodies. The error bounds are developed for analytic solutions to Euler's equations of motion. The results are applied to obtain a simplified analytic solution for Eulerian rates and angles. The results of a sample application of the range and error bound expressions for the case of the Galileo spacecraft experiencing transverse torques demonstrate the use of the bounds in analyses of rigid body spin change maneuvers.

  2. Competing on talent analytics. (United States)

    Davenport, Thomas H; Harris, Jeanne; Shapiro, Jeremy


    Do investments in your employees actually affect workforce performance? Who are your top performers? How can you empower and motivate other employees to excel? Leading-edge companies such as Google, Best Buy, Procter & Gamble, and Sysco use sophisticated data-collection technology and analysis to answer these questions, leveraging a range of analytics to improve the way they attract and retain talent, connect their employee data to business performance, differentiate themselves from competitors, and more. The authors present the six key ways in which companies track, analyze, and use data about their people-ranging from a simple baseline of metrics to monitor the organization's overall health to custom modeling for predicting future head count depending on various "what if" scenarios. They go on to show that companies competing on talent analytics manage data and technology at an enterprise level, support what analytical leaders do, choose realistic targets for analysis, and hire analysts with strong interpersonal skills as well as broad expertise.

  3. Highly Sensitive Optical Receivers

    CERN Document Server

    Schneider, Kerstin


    Highly Sensitive Optical Receivers primarily treats the circuit design of optical receivers with external photodiodes. Continuous-mode and burst-mode receivers are compared. The monograph first summarizes the basics of III/V photodetectors, transistor and noise models, bit-error rate, sensitivity and analog circuit design, thus enabling readers to understand the circuits described in the main part of the book. In order to cover the topic comprehensively, detailed descriptions of receivers for optical data communication in general and, in particular, optical burst-mode receivers in deep-sub-µm CMOS are presented. Numerous detailed and elaborate illustrations facilitate better understanding.

  4. Analytical Protocol (GC/ECNIMS) for OSWER's Response to OIG Report (2005-P-00022) on Toxaphene Analysis (United States)

    The research approached the large number and complexity of the analytes as four separate groups: technical toxaphene, toxaphene congeners (eight in number), chlordane, and organochlorine pesticides. This approach was advantageous because it eliminated potential interferences amon...

  5. Analysis of Environmental Contamination resulting from Catastrophic Incidents: Part two: Building Laboratory Capability by Selecting and Developing Analytical Methodologies (United States)

    Catastrophic incidents can generate a large number of samples with analytically diverse types including forensic, clinical, environmental, food, and others. Environmental samples include water, wastewater, soil, air, urban building and infrastructure materials, and surface resid...

  6. Simplified Analytical Method for Optimized Initial Shape Analysis of Self-Anchored Suspension Bridges and Its Verification

    Directory of Open Access Journals (Sweden)

    Myung-Rag Jung


    Full Text Available A simplified analytical method providing accurate unstrained lengths of all structural elements is proposed to find the optimized initial state of self-anchored suspension bridges under dead loads. For this, equilibrium equations of the main girder and the main cable system are derived and solved by evaluating the self-weights of cable members using unstrained cable lengths and iteratively updating both the horizontal tension component and the vertical profile of the main cable. Furthermore, to demonstrate the validity of the simplified analytical method, the unstrained element length method (ULM is applied to suspension bridge models based on the unstressed lengths of both cable and frame members calculated from the analytical method. Through numerical examples, it is demonstrated that the proposed analytical method can indeed provide an optimized initial solution by showing that both the simplified method and the nonlinear FE procedure lead to practically identical initial configurations with only localized small bending moment distributions.

  7. 压缩采样接收机抗ADC非线性影响的分析%Analysis of Random Demodulator Receiver Against ADC Nonlinearity

    Institute of Scientific and Technical Information of China (English)

    王庆国; 王华力; 曾显华


    For the wideband digital receiver is susceptible to Analog to Digital Converter(ADC)nonlinear influence,Research random demodulation receiver performance under the influence of the ADC nonlinear. This paper was based on deep understanding the working principle of Random Demodulation,modeled reasonably to ADC nonlinearity,analyzed how ADC nonlinearity impact the random demodulation.Comparing to traditional digital receiver,Random demodulation had a better robustness to ADC nonlinearity because of the reconstruction algorithm.Simulation results verified the above theoretical analysis.%针对宽带数字接收机易受模拟数字转换器( ADC )非线性的影响,研究压缩采样接收机在模拟数字转换器非线性影响下的性能。在深入剖析随机解调原理的基础上,通过对模拟数字转换器非线性的合理建模,分析了模拟数字转换器非线性因素对压缩采样接收机性能的影响。对比于传统数字接收机,压缩采样接收机得益于重构算法的优越性对模拟数字转换器非线性因素影响有更好的鲁棒性。仿真结果验证了上述理论分析。

  8. Automated Ground-Water Sampling and Analysis of Hexavalent Chromium using a “Universal” Sampling/Analytical System


    Venedam, Richard J.; Hartman, Mary J.; Hoffman, Dave A.; Scott R. Burge


    The capabilities of a “universal platform” for the deployment of analytical sensors in the field for long-term monitoring of environmental contaminants were expanded in this investigation. The platform was previously used to monitor trichloroethene in monitoring wells and at groundwater treatment systems (1,2). The platform was interfaced with chromium (VI) and conductivity analytical systems to monitor shallow wells installed adjacent to the Columbia River at the 100-D Area of the Hanford Si...

  9. Receiver System Analysis and Optimization (United States)


    passband and stopband specifications indicated on the graph. A synthesis module that realizes the abstract passive macro in the target process was...different from SPICE and its many clones, which forms the basis of almost all simulation programs in the market. The transistor level simulation

  10. Direct analysis of six antibiotics in wastewater samples using rapid high-performance liquid chromatography coupled with diode array detector: a chemometric study towards green analytical chemistry. (United States)

    Vosough, Maryam; Rashvand, Masoumeh; Esfahani, Hadi M; Kargosha, Kazem; Salemi, Amir


    In this work, a rapid HPLC-DAD method has been developed for the analysis of six antibiotics (amoxicillin, metronidazole, sulfamethoxazole, ofloxacine, sulfadiazine and sulfamerazine) in the sewage treatment plant influent and effluent samples. Decreasing the chromatographic run time to less than 4 min as well as lowering the cost per analysis, were achieved through direct injection of the samples into the HPLC system followed by chemometric analysis. The problem of the complete separation of the analytes from each other and/or from the matrix ingredients was resolved as a posteriori. The performance of MCR/ALS and U-PLS/RBL, as second-order algorithms, was studied and comparable results were obtained from implication of these modeling methods. It was demonstrated that the proposed methods could be used promisingly as green analytical strategies for detection and quantification of the targeted pollutants in wastewater samples while avoiding the more complicated high cost instrumentations.

  11. Noise and intercept point calculation for modern radio receiver planning

    DEFF Research Database (Denmark)

    Iversen, Christian Rye; Kolding, T. E.


    The paper presents analytical expressions for determining noise and intercept points for cascaded radio receiver stages. The theory allows for active receiver stages with frequency selectivity and flexible impedance levels. This makes the method highly usable for planning of modem receivers where...

  12. Usefulness of pinhole collimator in differential diagnosis of metastatic disease and degenerative joint disease in the vertebrae; Evaluation by receiver operating characteristics (ROC) analysis

    Energy Technology Data Exchange (ETDEWEB)

    Kosuda, Shigeru; Kawahara, Syunji; Ishibashi, Akihiko; Tamura, Kohei; Tsukatani, Yasushi; Fujii, Hiroshi (Okura National Hospital, Tokyo (Japan)); Kubo, Atsushi; Hashimoto, Shozo


    In order to evaluate the diagnostic efficacy of pinhole collimator (PHC) imaging combined with an X-ray for vertebral metastasis, our prospective study has employed receiver operating characteristics (ROC) analysis in 21 patients, 11 with osseous metastasis and 15 with degenerative joint disease in the lumbar vertebrae. PHC imaging provided better anatomic information on the extent of {sup 99m}Tc-MDP accumulation. PHC vertebral scintigraphy had a considerable impact on the decision-making process, although with variations and not very satisfactory results among the physicians with little experience. Our study suggests that PHC imaging and X-ray film are useful in differentiating between osseous metastasis and degenerative joint disease in the vertebra. (author).

  13. Treatment outcome and prognostic factor analysis in transplant-eligible Chinese myeloma patients receiving bortezomib-based induction regimens including the staged approach, PAD or VTD

    Directory of Open Access Journals (Sweden)

    Chim Chor


    Full Text Available Abstract Background We have reported promising outcomes using a staged approach, in which bortezomib/thalidomide/dexamethasone was used only in 14 patients with suboptimal response to VAD (vincristine/adriamycin/dexamethasone before autologous stem cell transplantation (ASCT. Here we compared the outcomes of the staged approach with frontline PAD (bortezomib/doxorubicin/dexamethasone or VTD (bortezomib/thalidomide/dexamethasone induction, and analysed prognostic factors for outcome. Patients and methods Ninety-one transplant-eligible Chinese patients received three induction regimens prior to ASCT [staged approach (N = 25, PAD (N = 31, VTD (N = 35]. and received thalidomide maintenance for 2 years post-ASCT. Results 43 (47.3% patients had International Staging System (ISS III disease. By an intention-to-treat analysis, the overall CR/nCR rate were 37.4% post-induction, and 62.6% post-ASCT. Five-year overall (OS and event-free (EFS survivals were 66% and 45.1%. There was no difference of the post-induction CR/nCR rate, EFS or OS between patients induced by these three regimens. Moreover, ISS III disease did not affect CR/nCR rates. Multivariate analysis showed that ISS and post-ASCT CR/nCR impacted OS while ISS and post-induction CR/nCR impacted EFS. Conclusions These three induction regimens produced comparable and favorable outcomes in myeloma. The unfavorable outcome of ISS stage III persisted despite upfront/early use of bortezomib. CR/nCR predicted favorable survivals.

  14. XRCC3 Thr241Met polymorphism and clinical outcomes of NSCLC patients receiving platinum-based chemotherapy: a systematic review and meta-analysis.

    Directory of Open Access Journals (Sweden)

    Xiao-yong Shen

    Full Text Available INTRODUCTION: X-ray repair cross-complementing protein 3 (XRCC3 is an essential gene involved in the double-strand break repair pathway. Published evidence has shown controversial results about the relationship between XRCC3 Thr241Met polymorphism and clinical outcomes of non-small cell lung cancer (NSCLC patients receiving platinum-based chemotherapy. METHODS: A systematic review and meta-analysis was performed to evaluate the predictive value of XRCC3 Thr241Met polymorphism on clinical outcomes of advanced NSCLC receiving platinum-based chemotherapy. Response to chemotherapy, overall survival (OS and progression-free survival (PFS were analyzed. RESULTS: A number of 11 eligible studies were identified according to the inclusion criteria. Carriers of the variant XRCC3 241Met allele were significantly associated with good response to platinum-based chemotherapy (ThrMet/MetMet vs. ThrThr: OR  = 1.509, 95% CI: 1.099-2.072, Pheterogeneity  = 0.618. The XRCC3 Thr241Met polymorphism was not associated with OS (MetMet vs. ThrThr, HR  = 0.939, 95% CI:0.651-1.356, Pheterogeneity  = 0.112 or PFS (MetMet vs. ThrThr, HR  = 0.960, 95% CI: 0.539-1.710, Pheterogeneity  = 0.198. Additionally, no evidence of publication bias was observed. CONCLUSIONS: This systematic review and meta-analysis shows that carriers of the XRCC3 241Met allele are associated with good response to platinum-based chemotherapy in advanced NSCLC, while the XRCC3 Thr241Met polymorphism is not associated with OS or PFS.

  15. Using Fourier and Taylor series expansion in semi-analytical deformation analysis of thick-walled isotropic and wound composite structures

    Directory of Open Access Journals (Sweden)

    Jiran L.


    Full Text Available Thick-walled tubes made from isotropic and anisotropic materials are subjected to an internal pressure while the semi-analytical method is employed to investigate their elastic deformations. The contribution and novelty of this method is that it works universally for different loads, different boundary conditions, and different geometry of analyzed structures. Moreover, even when composite material is considered, the method requires no simplistic assumptions. The method uses a curvilinear tensor calculus and it works with the analytical expression of the total potential energy while the unknown displacement functions are approximated by using appropriate series expansion. Fourier and Taylor series expansion are involved into analysis in which they are tested and compared. The main potential of the proposed method is in analyses of wound composite structures when a simple description of the geometry is made in a curvilinear coordinate system while material properties are described in their inherent Cartesian coordinate system. Validations of the introduced semi-analytical method are performed by comparing results with those obtained from three-dimensional finite element analysis (FEA. Calculations with Fourier series expansion show noticeable disagreement with results from the finite element model because Fourier series expansion is not able to capture the course of radial deformation. Therefore, it can be used only for rough estimations of a shape after deformation. On the other hand, the semi-analytical method with Fourier Taylor series expansion works very well for both types of material. Its predictions of deformations are reliable and widely exploitable.

  16. Social network data analytics

    CERN Document Server

    Aggarwal, Charu C


    Social network analysis applications have experienced tremendous advances within the last few years due in part to increasing trends towards users interacting with each other on the internet. Social networks are organized as graphs, and the data on social networks takes on the form of massive streams, which are mined for a variety of purposes. Social Network Data Analytics covers an important niche in the social network analytics field. This edited volume, contributed by prominent researchers in this field, presents a wide selection of topics on social network data mining such as Structural Pr

  17. Analytic Hilbert modules

    CERN Document Server

    Chen, Xiaoman


    The seminal 1989 work of Douglas and Paulsen on the theory of analytic Hilbert modules precipitated a number of major research efforts. This in turn led to some intriguing and valuable results, particularly in the areas of operator theory and functional analysis. With the field now beginning to blossom, the time has come to collect those results under one cover. Written by two of the most active and often-cited researchers in the field, Analytic Hilbert Modules reports on the progress made by the authors and others, including the characteristic space theory, rigidity, the equivalence problem, the Arveson modules, extension theory, and reproducing Hilbert spaces on n-dimensional complex space.

  18. Low complexity MIMO receivers

    CERN Document Server

    Bai, Lin; Yu, Quan


    Multiple-input multiple-output (MIMO) systems can increase the spectral efficiency in wireless communications. However, the interference becomes the major drawback that leads to high computational complexity at both transmitter and receiver. In particular, the complexity of MIMO receivers can be prohibitively high. As an efficient mathematical tool to devise low complexity approaches that mitigate the interference in MIMO systems, lattice reduction (LR) has been widely studied and employed over the last decade. The co-authors of this book are world's leading experts on MIMO receivers, and here they share the key findings of their research over years. They detail a range of key techniques for receiver design as multiple transmitted and received signals are available. The authors first introduce the principle of signal detection and the LR in mathematical aspects. They then move on to discuss the use of LR in low complexity MIMO receiver design with respect to different aspects, including uncoded MIMO detection...

  19. Analytic Methods for Cosmological Likelihoods


    Taylor, A. N.; Kitching, T. D.


    We present general, analytic methods for Cosmological likelihood analysis and solve the "many-parameters" problem in Cosmology. Maxima are found by Newton's Method, while marginalization over nuisance parameters, and parameter errors and covariances are estimated by analytic marginalization of an arbitrary likelihood function with flat or Gaussian priors. We show that information about remaining parameters is preserved by marginalization. Marginalizing over all parameters, we find an analytic...

  20. Nondestructive atomic compositional analysis of BeMgZnO quaternary alloys using ion beam analytical techniques

    Energy Technology Data Exchange (ETDEWEB)

    Zolnai, Z., E-mail: [Research Centre for Natural Sciences, Institute of Technical Physics and Materials Science (MFA), Konkoly-Thege M. út 29-33, H-1121 Budapest (Hungary); Toporkov, M. [Department of Electrical and Computer Engineering, Virginia Commonwealth University, 601W Main St, Richmond, VA 23284 (United States); Volk, J. [Research Centre for Natural Sciences, Institute of Technical Physics and Materials Science (MFA), Konkoly-Thege M. út 29-33, H-1121 Budapest (Hungary); Department of Electrical and Computer Engineering, Virginia Commonwealth University, 601W Main St, Richmond, VA 23284 (United States); Demchenko, D.O. [Department of Physics, Virginia Commonwealth University, 701W. Grace St., Richmond, VA 23284 (United States); Okur, S. [Department of Electrical and Computer Engineering, Virginia Commonwealth University, 601W Main St, Richmond, VA 23284 (United States); Szabó, Z. [Research Centre for Natural Sciences, Institute of Technical Physics and Materials Science (MFA), Konkoly-Thege M. út 29-33, H-1121 Budapest (Hungary); Özgür, Ü.; Morkoç, H.; Avrutin, V. [Department of Electrical and Computer Engineering, Virginia Commonwealth University, 601W Main St, Richmond, VA 23284 (United States); Kótai, E. [Wigner Research Centre for Physics, Institute for Particle and Nuclear Physics, Konkoly-Thege M. út 29-33, H-1121 Budapest (Hungary)


    Highlights: • BeMgZnO thin layers were grown with plasma-assisted molecular beam epitaxy (MBE). • The Be contents were accurately measured with RBS and proton elastic backscattering. • The Tauc bandgap was measured from optical transmittance experiments. • The bandgap has been varied between 3.26 eV and 4.62 eV via the Be and Mg content. • Experimental and density functional theory calculated bandgaps were in good agreement. - Abstract: The atomic composition with less than 1–2 atom% uncertainty was measured in ternary BeZnO and quaternary BeMgZnO alloys using a combination of nondestructive Rutherford backscattering spectrometry with 1 MeV He{sup +} analyzing ion beam and non-Rutherford elastic backscattering experiments with 2.53 MeV energy protons. An enhancement factor of 60 in the cross-section of Be for protons has been achieved to monitor Be atomic concentrations. Usually the quantitative analysis of BeZnO and BeMgZnO systems is challenging due to difficulties with appropriate experimental tools for the detection of the light Be element with satisfactory accuracy. As it is shown, our applied ion beam technique, supported with the detailed simulation of ion stopping, backscattering, and detection processes allows of quantitative depth profiling and compositional analysis of wurtzite BeZnO/ZnO/sapphire and BeMgZnO/ZnO/sapphire layer structures with low uncertainty for both Be and Mg. In addition, the excitonic bandgaps of the layers were deduced from optical transmittance measurements. To augment the measured compositions and bandgaps of BeO and MgO co-alloyed ZnO layers, hybrid density functional bandgap calculations were performed with varying the Be and Mg contents. The theoretical vs. experimental bandgaps show linear correlation in the entire bandgap range studied from 3.26 eV to 4.62 eV. The analytical method employed should help facilitate bandgap engineering for potential applications, such as solar blind UV photodetectors and

  1. Multivariate optimization of an analytical method for the analysis of dog and cat foods by ICP OES. (United States)

    da Costa, Silvânio Silvério Lopes; Pereira, Ana Cristina Lima; Passos, Elisangela Andrade; Alves, José do Patrocínio Hora; Garcia, Carlos Alexandre Borges; Araujo, Rennan Geovanny Oliveira


    Experimental design methodology was used to optimize an analytical method for determination of the mineral element composition (Al, Ca, Cd, Cr, Cu, Ba, Fe, K, Mg, Mn, P, S, Sr and Zn) of dog and cat foods. Two-level full factorial design was applied to define the optimal proportions of the reagents used for microwave-assisted sample digestion (2.0 mol L(-1) HNO3 and 6% m/v H2O2). A three-level factorial design for two variables was used to optimize the operational conditions of the inductively coupled plasma optical emission spectrometer, employed for analysis of the extracts. A radiofrequency power of 1.2 kW and a nebulizer argon flow of 1.0 L min(-1) were selected. The limits of quantification (LOQ) were between 0.03 μg g(-1) (Cr, 267.716 nm) and 87 μg g(-1) (Ca, 373.690 nm). The trueness of the optimized method was evaluated by analysis of five certified reference materials (CRMs): wheat flour (NIST 1567a), bovine liver (NIST 1577), peach leaves (NIST 1547), oyster tissue (NIST 1566b), and fish protein (DORM-3). The recovery values obtained for the CRMs were between 80 ± 4% (Cr) and 117 ± 5% (Cd), with relative standard deviations (RSDs) better than 5%, demonstrating that the proposed method offered good trueness and precision. Ten samples of pet food (five each of cat and dog food) were acquired at supermarkets in Aracaju city (Sergipe State, Brazil). Concentrations in the dog food ranged between 7.1 mg kg(-1) (Ba) and 2.7 g kg(-1) (Ca), while for cat food the values were between 3.7 mg kg(-1) (Ba) and 3.0 g kg(-1) (Ca). The concentrations of Ca, K, Mg, P, Cu, Fe, Mn, and Zn in the food were compared with the guidelines of the United States' Association of American Feed Control Officials (AAFCO) and the Brazilian Ministry of Agriculture, Livestock, and Food Supply (Ministério da Agricultura, Pecuária e Abastecimento-MAPA).

  2. Analytic Circuit Model of Ballistic Nanowire Metal-Oxide-Semiconductor Field-Effect Transistor for Transient Analysis (United States)

    Numata, Tatsuhiro; Uno, Shigeyasu; Kamakura, Yoshinari; Mori, Nobuya; Nakazato, Kazuo


    A fully analytic and explicit model of device properties in the ballistic transport in gate-all-around metal-oxide-semiconductor field-effect transistors (MOSFETs) is proposed, which enables circuit simulations. The electrostatic potential distribution in the wire cross section is approximated by a parabolic function. Using the applied potential, the energy levels of electrons are analytically obtained in terms of a single unknown parameter by perturbation theory. Ballistic current is obtained in terms of an unknown parameter using the analytic expression of the electron energy level and the current equation for ballistic transport. We analytically derive the parameter with a one-of-a-kind approximate methodology. With the obtained parameter, the fully analytic and explicit model of device properties such as energy levels, ballistic current, and effective capacitance is derived with satisfactory accuracy compared with the numerical simulation results. Finally, we perform a transient simulation using a circuit simulator, introducing our model to it as a Verilog-A script.

  3. Measuring social inequality with quantitative methodology: Analytical estimates and empirical data analysis by Gini and k indices (United States)

    Inoue, Jun-ichi; Ghosh, Asim; Chatterjee, Arnab; Chakrabarti, Bikas K.


    Social inequality manifested across different strata of human existence can be quantified in several ways. Here we compute non-entropic measures of inequality such as Lorenz curve, Gini index and the recently introduced k index analytically from known distribution functions. We characterize the distribution functions of different quantities such as votes, journal citations, city size, etc. with suitable fits, compute their inequality measures and compare with the analytical results. A single analytic function is often not sufficient to fit the entire range of the probability distribution of the empirical data, and fit better to two distinct functions with a single crossover point. Here we provide general formulas to calculate these inequality measures for the above cases. We attempt to specify the crossover point by minimizing the gap between empirical and analytical evaluations of measures. Regarding the k index as an 'extra dimension', both the lower and upper bounds of the Gini index are obtained as a function of the k index. This type of inequality relations among inequality indices might help us to check the validity of empirical and analytical evaluations of those indices.

  4. Delphi Accounts Receivable Module - (United States)

    Department of Transportation — Delphi accounts receivable module contains the following data elements, but are not limited to customer information, cash receipts, line of accounting details, bill...

  5. Analytical mechanics

    CERN Document Server

    Helrich, Carl S


    This advanced undergraduate textbook begins with the Lagrangian formulation of Analytical Mechanics and then passes directly to the Hamiltonian formulation and the canonical equations, with constraints incorporated through Lagrange multipliers. Hamilton's Principle and the canonical equations remain the basis of the remainder of the text. Topics considered for applications include small oscillations, motion in electric and magnetic fields, and rigid body dynamics. The Hamilton-Jacobi approach is developed with special attention to the canonical transformation in order to provide a smooth and logical transition into the study of complex and chaotic systems. Finally the text has a careful treatment of relativistic mechanics and the requirement of Lorentz invariance. The text is enriched with an outline of the history of mechanics, which particularly outlines the importance of the work of Euler, Lagrange, Hamilton and Jacobi. Numerous exercises with solutions support the exceptionally clear and concise treatment...

  6. A multiple receiver - multiple transmitter VLF high-order differential analysis evaluation network for near real-time detection and discrimination of seismic-ionospheric precursor phenomena (United States)

    Skeberis, Christos; Zaharis, Zaharias; Xenos, Thomas; Spatalas, Spyridon; Stratakis, Dimitrios; Maggipinto, Tommaso; Biagi, Pier francesco


    This study provides an evaluation of the application of high-order differential analysis on VLF signals on a multiple-receiver multiple-transmitter network. This application provides a method for near-real-time detection of disturbances that can be attributed to seismic-ionospheric precursor phenomena and can discriminate disturbances that could be classified as false positives and thus should be attributed to other geomagnetic influences. VLF data acquired in Thessaloniki, Greece (40.59N, 22,78E) Herakleion, Greece (35.31N, 25.10E), Nicosia, Cyprus (35.17N, 33.35E), Italy (42.42N, 13.08E) and transmitted by the VLF station in Tavolara, Italy (ICV station 40.923N, 9.731E) and the station in Keflavik, Iceland (ICE 64.02N, 22.57W) from January 2015 to January 2016 were used for the purpose of this paper. The receivers have been developed by Elettronika Srl and are part of the International Network for Frontier Research on Earthquake Precursors (INFREP). The process applied for this study has been further developed and is based on differential analysis. The signals undergo transformation using an enhanced version of the Hilbert Huang Transform, and relevant spectra are produced. On the product of this process, differential analysis is applied. Finally, the method produces the correlation coefficient of signals that are on the same path over an earthquake epicenter in order to highlight disturbances, and on the opposite can make comparisons with unrelated transmitted signals of different paths to eliminate disturbances that are not localized to the area of interest. This improvement provides a simple method of noise cancellation to signals that would otherwise be considered as false positives. A further evaluation of the method is provided with the presentation and discussion of sample results. The method seems to be a robust tool of analysis of VLF signals and also an automatic detection tool with built-in noise cancellation of outside disturbances.

  7. Analytic QCD Binding Potentials

    CERN Document Server

    Fried, H M; Grandou, T; Sheu, Y -M


    This paper applies the analytic forms of a recent non-perturbative, manifestly gauge- and Lorentz-invariant description (of the exchange of all possible virtual gluons between quarks ($Q$) and/or anti-quarks ($\\bar{Q}$) in a quenched, eikonal approximation) to extract analytic forms for the binding potentials generating a model $Q$-$\\bar{Q}$ "pion", and a model $QQQ$ "nucleon". Other, more complicated $Q$, $\\bar{Q}$ contributions to such color-singlet states may also be identified analytically. An elementary minimization technique, relevant to the ground states of such bound systems, is adopted to approximate the solutions to a more proper, but far more complicated Schroedinger/Dirac equation; the existence of possible contributions to the pion and nucleon masses due to spin, angular momentum, and "deformation" degrees of freedom is noted but not pursued. Neglecting electromagnetic and weak interactions, this analysis illustrates how the one new parameter making its appearance in this exact, realistic formali...

  8. Miniaturizing and automation of free acidity measurements for uranium (VI)-HNO3 solutions: Development of a new sequential injection analysis for a sustainable radio-analytical chemistry. (United States)

    Néri-Quiroz, José; Canto, Fabrice; Guillerme, Laurent; Couston, Laurent; Magnaldo, Alastair; Dugas, Vincent


    A miniaturized and automated approach for the determination of free acidity in solutions containing uranium (VI) is presented. The measurement technique is based on the concept of sequential injection analysis with on-line spectroscopic detection. The proposed methodology relies on the complexation and alkalimetric titration of nitric acid using a pH 5.6 sodium oxalate solution. The titration process is followed by UV/VIS detection at 650nm thanks to addition of Congo red as universal pH indicator. Mixing sequence as well as method validity was investigated by numerical simulation. This new analytical design allows fast (2.3min), reliable and accurate free acidity determination of low volume samples (10µL) containing uranium/[H(+)] moles ratio of 1:3 with relative standard deviation of developed sequential injection analysis method greatly improves the standard off-line oxalate complexation and alkalimetric titration method by reducing thousand fold the required sample volume, forty times the nuclear waste per analysis as well as the analysis time by eight fold. These analytical parameters are important especially in nuclear-related applications to improve laboratory safety, personnel exposure to radioactive samples and to drastically reduce environmental impacts or analytical radioactive waste.

  9. Croatian Analytical Terminology

    Directory of Open Access Journals (Sweden)

    Kastelan-Macan; M.


    oljić, I. Eškinja, M. Kaštelan-Macan, I. Piljac. Š. Cerjan-Stefanović and others translated Chromatographic nomenclature (IUPAC Compendium of Analytical Nomenclature. The related area is covered by books of V. Grdinić and F. Plavšić.During the project Croatian nomenclature of analytical chemistry there shall be an analysis of dictionaries, textbooks, handbooks, professional and scientific monographs and articles, official governmental and economic publications, regulations and instructions. The Compendium of Analytical Nomenclature is expected to have been translated and the translation mostly adjusted to the Croatian language standard. EUROLAB and EURACHEM documents related to quality assurance in analytical laboratories, especially in research and development have not yet been included in the Compendium, and due to the globalization of the information and service market, such documents need to be adjusted to the Croatian language standard in collaboration with consultants from the Institute for Croatian Language and Lingiustics. The terms shall be sorted according to the analytical process from sampling to final information.It is expected that the project's results shall be adopted by the Croatian scientific and professional community, so as to raise the awareness of the necessity of using Croatian terms in everyday professional communication and particularly in scientific and educational work. The Croatian language is rich enough for all analytical terms to be translated appropriately. This shall complete the work our predecessors began several times. We face a great challenge of contributing to the creation of the Croatian scientific terminology and believe we shall succeed.

  10. Studies on application of neutron activation analysis -Applied research on air pollution monitoring and development of analytical method of environmental samples

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Yong Sam; Moon, Jong Hwa; Chung, Young Ju; Jeong, Eui Sik; Lee, Sang Mi; Kang, Sang Hun; Cho, Seung Yeon; Kwon, Young Sik; Chung, Sang Wuk; Lee, Kyu Sung; Chun, Ki Hong; Kim, Nak Bae; Lee, Kil Yong; Yoon, Yoon Yeol; Chun, Sang Ki


    This research report is written for results of applied research on air pollution monitoring using instrumental neutron activation analysis. For identification and standardization of analytical method, 24 environmental samples are analyzed quantitatively, and accuracy and precision of this method are measured. Using airborne particulate matter and biomonitor chosen as environmental indicators, trace elemental concentrations of sample collected at urban and rural site monthly are determined ant then the calculation of statistics and the factor analysis are carried out for investigation of emission source. Facilities for NAA are installed in a new HANARO reactor, functional test is performed for routine operation. In addition, unified software code for NAA is developed to improve accuracy, precision and abilities of analytical processes. (author). 103 refs., 61 tabs., 19 figs.

  11. Transient Thermal Analysis of Heat Pipe Receiver under Microgravity%微重力条件下热管吸热器瞬态热分析

    Institute of Scientific and Technical Information of China (English)

    桂小红; 宋香娥


    基于微重力条件下的导热控制微分方程,采用焓法对热管吸热器相变材料容器进行了二维数值建模与仿真,在同时考虑空穴和相变的情况下,对微重力条件下蓄热单元相变传热进行了模拟计算,分析了空穴率对蓄热容器内部的温度场和热性能的影响,并将计算结果同美国航空航天局(NASA )方案热管吸热器蓄热单元相变传热计算结果进行了比较,验证了文中微重力条件下计算模型的合理性与准确性。研究结果表明:空穴影响着蓄热单元相变的进程,空穴的存在增加了容器内部的温度梯度,使得容器的蓄热能力降低;由于热管径向温差较小,热管壁温在相变材料熔点附近变化较小,从而在一定程度上能缓解热斑和热松脱现象。%High temperature heat pipe receivers are commonly used as a core component of space solar dynamic power system . On the base of heat conduction governing differential equation under microgravity , two‐dimensional numerical analysis of PCM container was conducted by a enthalpy method . With both void cavity and phase change considered , thermal performance of heat pipe receiver was analyzed . Numerical results were compared with NASA results . The accuracy of calculation model under gravity was verified .The results indicate that void cavity influences the process of phase change . T he void cavity reduces the utility and thermal storage ability of PCM . The temperature gradient of PCM zone is very significant because of the void cavity . The PCM contained in the integrated heat pipe performs the averaging function of the heat loads . Normal working of wick ensures the uniformity of heat pipe , thus heat pipe receiver alleviates thermal spot and thermal ratcheting .

  12. Addressing the Vaccine Hesitancy Continuum: An Audience Segmentation Analysis of American Adults Who Did Not Receive the 2009 H1N1 Vaccine. (United States)

    Ramanadhan, Shoba; Galarce, Ezequiel; Xuan, Ziming; Alexander-Molloy, Jaclyn; Viswanath, Kasisomayajula


    Understanding the heterogeneity of groups along the vaccine hesitancy continuum presents an opportunity to tailor and increase the impact of public engagement efforts with these groups. Audience segmentation can support these goals, as demonstrated here in the context of the 2009 H1N1 vaccine. In March 2010, we surveyed 1569 respondents, drawn from a nationally representative sample of American adults, with oversampling of racial/ethnic minorities and persons living below the United States Federal Poverty Level. Guided by the Structural Influence Model, we assessed knowledge, attitudes, and behaviors related to H1N1; communication outcomes; and social determinants. Among those who did not receive the vaccine (n = 1166), cluster analysis identified three vaccine-hesitant subgroups. Disengaged Skeptics (67%) were furthest from vaccine acceptance, with low levels of concern and engagement. The Informed Unconvinced (19%) were sophisticated consumers of media and health information who may not have been reached with information to motivate vaccination. The Open to Persuasion cluster (14%) had the highest levels of concern and motivation and may have required engagement about vaccination broadly. There were significant sociodemographic differences between groups. This analysis highlights the potential to use segmentation techniques to identify subgroups on the vaccine hesitancy continuum and tailor public engagement efforts accordingly.

  13. Differential recall bias, intermediate confounding, and mediation analysis in life course epidemiology: An analytic framework with empirical example.

    Directory of Open Access Journals (Sweden)

    Mashhood Ahmed Sheikh


    Full Text Available The mechanisms by which childhood socioeconomic status (CSES affects adult mental health, general health, and well-being are not clear. Moreover, the analytical assumptions employed when assessing mediation in social and psychiatric epidemiology are rarely explained. The aim of this paper was to explain the intermediate confounding assumption, and to quantify differential recall bias in the association between CSES, childhood abuse, and mental health (SCL-10, general health (EQ-5D, and subjective well-being (SWLS. Furthermore, we assessed the mediating role of psychological and physical abuse in the association between CSES and mental health, general health, and well-being; and the influence of differential recall bias in the estimation of total effects, direct effects, and proportion of mediated effects. The assumptions employed when assessing mediation are explained with reference to a causal diagram. Poisson regression models (relative risk, RR and 99% CI were used to assess the association between CSES and psychological and physical abuse in childhood. Mediation analysis (difference method was used to assess the indirect effect of CSES (through psychological and physical abuse in childhood on mental health, general health, and well-being. Psychological abuse and physical abuse mediated the association between CSES and adult mental health, general health, and well-being (6-16% among men and 7-14% among women, p<0.001. The results suggest that up to 27% of the association between CSES and childhood abuse, 23% of the association between childhood abuse, and mental health, general health, and well-being, and 44% of the association between CSES and mental health, general health, and well-being is driven by differential recall bias. Assessing mediation with cross-sectional data (exposure, mediator, and outcome measured at the same time showed that the total effects and direct effects were vastly overestimated (biased upwards. Consequently, the



    Mladen Varga; Miljenko Vuković


    Trends in data processing for decision support show that business users need business analytics, i.e. analytical applications which incorporate a variety of business oriented data analysis techniques and task-specific knowledge. The paper discusses the feasibility of investment in two models of implementing business analytics: custom development and packed analytical applications. The consequences of both models are shown on two models of business analytics implementation in Croatia.


    Directory of Open Access Journals (Sweden)

    Mladen Varga


    Full Text Available Trends in data processing for decision support show that business users need business analytics, i.e. analytical applications which incorporate a variety of business oriented data analysis techniques and task-specific knowledge. The paper discusses the feasibility of investment in two models of implementing business analytics: custom development and packed analytical applications. The consequences of both models are shown on two models of business analytics implementation in Croatia.

  16. Robust analysis of the hydrophobic basic analytes loratadine and desloratadine in pharmaceutical preparations and biological fluids by sweeping-cyclodextrin-modified micellar electrokinetic chromatography. (United States)

    El-Awady, Mohamed; Belal, Fathalla; Pyell, Ute


    The analysis of hydrophobic basic analytes by micellar electrokinetic chromatography (MEKC) is usually challenging because of the tendency of these analytes to be adsorbed onto the inner capillary wall in addition to the difficulty to separate these compounds as they exhibit extremely high retention factors. A robust and reliable method for the simultaneous determination of loratadine (LOR) and its major metabolite desloratadine (DSL) is developed based on cyclodextrin-modified micellar electrokinetic chromatography (CD-MEKC) with acidic sample matrix and basic background electrolyte (BGE). The influence of the sample matrix on the reachable focusing efficiency is studied. It is shown that the application of a low pH sample solution mitigates problems associated with the low solubility of the hydrophobic basic analytes in aqueous solution while having advantages with regard to on-line focusing. Moreover, the use of a basic BGE reduces the adsorption of these analytes in the separation compartment. The separation of the studied analytes is achieved in less than 7min using a BGE consisting of 10mmolL(-1) disodium tetraborate buffer, pH 9.30 containing 40mmolL(-1) SDS and 20mmolL(-1) hydroxypropyl-β-CD while the sample solution is composed of 10mmolL(-1) phosphoric acid, pH 2.15. A full validation study of the developed method based on the pharmacopeial guidelines is performed. The method is successfully applied to the analysis of the studied drugs in tablets without interference of tablet additives as well as the analysis of spiked human urine without any sample pretreatment. Furthermore, DSL can be detected as an impurity in LOR bulk powder at the stated pharmacopeial limit (0.1%, w/w). The selectivity of the developed method allows the analysis of LOR and DSL in combination with the co-formulated drug pseudoephedrine. It is shown that in CD-MEKC with basic BGE, solute-wall interactions are effectively suppressed allowing the development of efficient and precise

  17. Derivation and analysis of the analytical velocity and vortex stretching expressions for an O (N log N)-FMM

    DEFF Research Database (Denmark)

    Berdowski, T.; Walther, Jens Honore; Ferreira, Célia Maria Dias


    In the current paper, a method for deriving the analytical expressions for the velocity and vortex stretching terms as a function of the spherical multipole expansion approximation of the vector potential is presented. These terms are essential in the context of 3D Lagrangian vortex particle...

  18. Analytical travelling wave solutions and parameter analysis for the (2+1)-dimensional Davey–Stewartson-type equations

    Indian Academy of Sciences (India)

    Jianping Shi; Jibin Li; Shumin Li


    By using dynamical system method, this paper considers the (2+1)-dimensional Davey–Stewartson-type equations. The analytical parametric representations of solitary wave solutions, periodic wave solutions as well as unbounded wave solutions are obtained under different parameter conditions. A few diagrams corresponding to certain solutions illustrate some dynamical properties of the equations.

  19. Matrix effects break the LC behavior rule for analytes in LC-MS/MS analysis of biological samples (United States)

    High-performance liquid chromatography (HPLC) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) are generally accepted as the preferred techniques for detecting and quantitating analytes of interest in biological matrices on the basis of the rule that one chemical compound yields one LC-...

  20. What Is the Relevance of the GMAT Analytical Writing Assessment for Management Education? A Critical Analysis, Part I. (United States)

    Rogers, Priscilla S.; Rymer, Jone


    Comments on the Analytical Writing Assessment (AWA), a new component of the Graduate Management Admissions Test (GMAT). Examines the AWA's historical significance and addresses questions regarding the relevance of the writing test for management education. Finds that the AWA is of limited value as a writing assessment and will meet only some of…

  1. What Is the Functional Value of the GMAT Analytical Writing Assessment for Management Education? A Critical Analysis, Part 2. (United States)

    Rogers, Priscilla S.; Rymer, Jone


    Analyzes the Analytical Writing Assessment's (AWA) contribution as a performance assessment. Critiques its potential usefulness as a diagnostic tool for management education. Concludes that the AWA does not meet the expectations of GMAT-user schools who endorsed the test as a diagnostic instrument for identifying student deficiencies. States that…

  2. Web Analytics


    Mužík, Zbyněk


    Práce se zabývá problematikou měření ukazatelů souvisejících s provozem webových stránek a aplikací a technologickými prostředky k tomu sloužícími ? Web Analytics (WA). Hlavním cílem práce je otestovat a porovnat vybrané zástupce těchto nástrojů a podrobit je srovnání podle objektivních kriterií, dále také kritické zhodnocení možností WA nástrojů obecně. V první části se práce zaměřuje na popis různých způsobů měření provozu na WWW a definuje související metriky. Poskytuje také přehled dostup...

  3. Delineating a Retesting Zone Using Receiver Operating Characteristic Analysis on Serial QuantiFERON Tuberculosis Test Results in US Healthcare Workers

    Directory of Open Access Journals (Sweden)

    Wendy Thanassi


    Full Text Available Objective. To find a statistically significant separation point for the QuantiFERON Gold In-Tube (QFT interferon gamma release assay that could define an optimal “retesting zone” for use in serially tested low-risk populations who have test “reversions” from initially positive to subsequently negative results. Method. Using receiver operating characteristic analysis (ROC to analyze retrospective data collected from 3 major hospitals, we searched for predictors of reversion until statistically significant separation points were revealed. A confirmatory regression analysis was performed on an additional sample. Results. In 575 initially positive US healthcare workers (HCWs, 300 (52.2% had reversions, while 275 (47.8% had two sequential positive tests. The most statistically significant (Kappa = 0.48, chi-square = 131.0, P<0.001 separation point identified by the ROC for predicting reversion was the tuberculosis antigen minus-nil (TBag-nil value at 1.11 International Units per milliliter (IU/mL. The second separation point was found at TBag-nil at 0.72 IU/mL (Kappa = 0.16, chi-square = 8.2, P<0.01. The model was validated by the regression analysis of 287 HCWs. Conclusion. Reversion likelihood increases as the TBag-nil approaches the manufacturer's cut-point of 0.35 IU/mL. The most statistically significant separation point between those who test repeatedly positive and those who revert is 1.11 IU/mL. Clinicians should retest low-risk individuals with initial QFT results < 1.11 IU/mL.

  4. Method development for the redox speciation analysis of iron by ion chromatography-inductively coupled plasma mass spectrometry and carryover assessment using isotopically labeled analyte analogues. (United States)

    Wolle, Mesay Mulugeta; Fahrenholz, Timothy; Rahman, G M Mizanur; Pamuku, Matt; Kingston, H M 'Skip'; Browne, Damien


    An ion chromatography-inductively coupled plasma mass spectrometry (IC-ICP-MS) method was developed for the redox speciation analysis of iron (Fe) based on in-column complexation of Fe(2+) and Fe(3+) by dipicolinic acid (DPA). The effects of column type, mobile phase composition and molecular ion interference were studied in the method optimization. The carryover of the target species in the IC-ICP-MS method was uniquely and effectively evaluated using isotopically enriched analogues of the analytes ((54)Fe(2+) and (57)Fe(3+)). Standard solutions of the enriched standards were injected into the system following analysis of a sample, and the ratios of the isotopes of iron in the enriched standards were calculated based on the chromatographic peak areas. The concentrations of the analytes carried over from the sample to the enriched standards were determined using the quantitative relationship in isotope dilution mass spectrometry (IDMS). In contrast to the routine way of evaluating carryover effect by injecting a blank solution after sample analysis, the use of isotopically enriched standards identified significant analyte carryover in the present method. Extensive experiments were carried out to systematically identify the source of the carryover and to eliminate the problem; the separation column was found to be the exclusive source. More than 95% of the analyte carryover was eliminated by reducing the length of the column. The detection limit of the IC-ICP-MS method (MDL) for the iron species was 2ngg(-1). The method was used to determine Fe(2+) and Fe(3+) in synthetic aqueous standard solutions and a beverage sample.

  5. Earth Science Data Analytics: Bridging Tools and Techniques with the Co-Analysis of Large, Heterogeneous Datasets (United States)

    Kempler, Steve; Mathews, Tiffany


    The continuum of ever-evolving data management systems affords great opportunities to the enhancement of knowledge and facilitation of science research. To take advantage of these opportunities, it is essential to understand and develop methods that enable data relationships to be examined and the information to be manipulated. This presentation describes the efforts of the Earth Science Information Partners (ESIP) Federation Earth Science Data Analytics (ESDA) Cluster to understand, define, and facilitate the implementation of ESDA to advance science research. As a result of the void of Earth science data analytics publication material, the cluster has defined ESDA along with 10 goals to set the framework for a common understanding of tools and techniques that are available and still needed to support ESDA.

  6. Numerical analysis of a photonic crystal fiber based on a surface plasmon resonance sensor with an annular analyte channel (United States)

    Liu, Chao; Yang, Lin; Su, Weiquan; Wang, Famei; Sun, Tao; Liu, Qiang; Mu, Haiwei; Chu, Paul K.


    A sensing structure is designed with a photonic crystal fiber based on a surface plasmon resonance (PCF-SPR) sensor using gold as the sensitive material. The benefit of the structure is to reduce the difficulty in gold deposition, because the Au film is deposited on the outside of the fiber core instead of on the holes filled with analyte inside the core. The properties of the sensor are numerically calculated by the finite element method. The results show that the thickness of the gold film, refractive index of the analyte, and radius of the central hole affect the sensing performance of the PCF-SPR. By optimizing the model, an extra graphene layer with the thickness of 20 nm is deposited on the gold film in the model. The maximum spectral sensitivity can be as high as 7500 nm/RIU for the sensor with the gold-graphene composite film as the sensitive material.

  7. Recent Advances in the Analysis of Macromolecular Interactions Using the Matrix-Free Method of Sedimentation in the Analytical Ultracentrifuge

    Directory of Open Access Journals (Sweden)

    Stephen E. Harding


    Full Text Available Sedimentation in the analytical ultracentrifuge is a matrix free solution technique with no immobilisation, columns, or membranes required and can be used to study self-association and complex or “hetero”-interactions, stoichiometry, reversibility and interaction strength of a wide variety of macromolecular types and across a very large dynamic range (dissociation constants from 10−12 M to 10−1 M. We extend an earlier review specifically highlighting advances in sedimentation velocity and sedimentation equilibrium in the analytical ultracentrifuge applied to protein interactions and mucoadhesion and to review recent applications in protein self-association (tetanus toxoid, agrin, protein-like carbohydrate association (aminocelluloses, carbohydrate-protein interactions (polysaccharide-gliadin, nucleic-acid protein (G-duplexes, nucleic acid-carbohydrate (DNA-chitosan and finally carbohydrate-carbohydrate (xanthan-chitosan and a ternary polysaccharide complex interactions.

  8. Derivation and analysis on the analytical structure of interval type-2 fuzzy controller with two nonlinear fuzzy sets for each input variable

    Institute of Scientific and Technical Information of China (English)

    Bin-bin LEI; Xue-chao DUAN; Hong BAO; Qian XU


    Type-2 fuzzy controllers have been mostly viewed as black-box function generators. Revealing the analytical struc-ture of any type-2 fuzzy controller is important as it will deepen our understanding of how and why a type-2 fuzzy controller functions and lay a foundation for more rigorous system analysis and design. In this study, we derive and analyze the analytical structure of an interval type-2 fuzzy controller that uses the following identical elements: two nonlinear interval type-2 input fuzzy sets for each variable, four interval type-2 singleton output fuzzy sets, a Zadeh AND operator, and the Karnik-Mendel type reducer. Through dividing the input space of the interval type-2 fuzzy controller into 15 partitions, the input-output relationship for each local region is derived. Our derivation shows explicitly that the controller is approximately equivalent to a nonlinear proportional integral or proportional differential controller with variable gains. Furthermore, by comparing with the analytical structure of its type-1 counterpart, potential advantages of the interval type-2 fuzzy controller are analyzed. Finally, the reliability of the analysis results and the effectiveness of the interval type-2 fuzzy controller are verified by a simulation and an experiment.

  9. The Integrated Oncology Program of the Italian Ministry of Health. Analytical and clinical validation of new biomarkers for early diagnosis: network, resources, methodology, quality control, and data analysis. (United States)

    Paradiso, Angelo; Mangia, Anita; Orlando, Claudio; Verderio, Paolo; Belfiglio, Maurizio; Marchetti, Antonio; Bertario, Lucio; Chiappetta, Gennaro; Gion, Massimo; Tonini, Gian Paolo; Podo, Franca; Vocaturo, Amina; Silvestrini, Rosella; Romani, Massimo; Belloni, Elena; Cavallo, Delia; Ulivi, Paola; Tommasi, Stefania; Steffan, Agostino; Russo, Antonio; Alessio, Massimo; Calistri, Daniele; Zancan, Matelda; Parrela, Paola; Broggini, Massimo; Giuseppe, Antonio; Buttitta, Fiamma; Finocchiaro, Gaetano; Mazzocco, Katia; Veronesi, Giulia; Landuzzi, Lorena; Benevolo, Maria; Mariani, Luciano; De Marco, Federico; Venuti, Aldo; Giannelli, Gianluigi; Quaranta, Michele; Trojano, Vito


    In 2007, an Italian cancer research group proposed a specific concerted action aimed at the "analytical and clinica validation of new biomarkers for early diagnosis: Network, resources, methodology, quality control, and data analysis." The proposal united 37 national operative units involved in different biomarker studies and it created a strong coordinative body with the necessary expertise in methodologies, statistical analysis, quality control, and biological resources to perform ad hoc validation studies for new biomarkers of early cancer diagnosis. The action, financed by the Italian Ministry of Health within the Integrated Oncology Program (PIO) coordinated by NCI-Istituto Tumori Bari, started in 2007 and activated 7 projects, each of which focused on disease-specific biomarker studies. Overall, the 37 participating units proposed studies on 50 biomarkers, including analytical and clinical validation procedures. Clusters of units were specifically involved in research of early-detection biomarkers for cancers of the lung, digestive tract, prostate/bladder, and nervous system, as well as female cancers. Furthermore, a cluster involved in biomarkers for bioimaging and infection-related cancers was created. The first investigators' meeting, "Analytical and clinical validation of new biomarkers for early diagnosis," was held on 9 September 2008 in Bari. During this meeting, methodological aspects, scientific programs and preliminary results were presented and discussed.

  10. Thermoelastic analysis of spent fuel and high level radioactive waste repositories in salt. A semi-analytical solution. [JUDITH

    Energy Technology Data Exchange (ETDEWEB)

    St. John, C.M.


    An underground repository containing heat generating, High Level Waste or Spent Unreprocessed Fuel may be approximated as a finite number of heat sources distributed across the plane of the repository. The resulting temperature, displacement and stress changes may be calculated using analytical solutions, providing linear thermoelasticity is assumed. This report documents a computer program based on this approach and gives results that form the basis for a comparison between the effects of disposing of High Level Waste and Spent Unreprocessed Fuel.

  11. The design process for a pumpkin balloon: structural synthesis, structural analysis, and analytical assessment of some critical design issues (United States)

    Schur, W. W.

    Effects of varying parameters in the design of super-pressure balloons of the "pumpkin" shape such as gore design, tendon stiffness, and structural lack-of-fit between tendons and gore seams are exhibited in analytical studies. The importance of an accurate representation of Poisson's effect for the film is demonstrated. Important design aspects that affect load paths and robustness of the design are discussed together with their resolution and quantification where applicable.

  12. [Comparison of LCD and CRT monitors for detection of pulmonary nodules and interstitial lung diseases on digital chest radiographs by using receiver operating characteristic analysis]. (United States)

    Ikeda, Ryuji; Katsuragawa, Shigehiko; Shimonobou, Toshiaki; Hiai, Yasuhiro; Hashida, Masahiro; Awai, Kazuo; Yamashita, Yasuyuki; Doi, Kunio


    Soft copy reading of digital images has been practiced commonly in the PACS environment. In this study, we compared liquid-crystal display (LCD) and cathode-ray tube (CRT) monitors for detection of pulmonary nodules and interstitial lung diseases on digital chest radiographs by using receiver operating characteristic (ROC) analysis. Digital chest images with a 1000x1000 matrix size and a 8 bit grayscale were displayed on LCD/CRT monitor with 2M pixels in each observer test. Eight and ten radiologists participated in the observer tests for detection of nodules and interstitial diseases, respectively. In each observer test, radiologists marked their confidence levels for diagnosis of pulmonary nodules or interstitial diseases. The detection performance of radiologists was evaluated by ROC analyses. The average Az values (area under the ROC curve) in detecting pulmonary nodules with LCD and CRT monitors were 0.792 and 0.814, respectively. In addition, the average Az values in detecting interstitial diseases with LCD and CRT monitors were 0.951 and 0.953, respectively. There was no statistically significant difference between LCD and CRT for both detection of pulmonary nodules (P=0.522) and interstitial lung diseases (P=0.869). Therefore, we believe that the LCD monitor instead of the CRT monitor can be used for the diagnosis of pulmonary nodules and interstitial lung diseases in digital chest images.

  13. Capillary electrophoresis analysis of conventional splicing assays: IARC analytical and clinical classification of 31 BRCA2 genetic variants. (United States)

    de Garibay, Gorka Ruiz; Acedo, Alberto; García-Casado, Zaida; Gutiérrez-Enríquez, Sara; Tosar, Alicia; Romero, Atocha; Garre, Pilar; Llort, Gemma; Thomassen, Mads; Díez, Orland; Pérez-Segura, Pedro; Díaz-Rubio, Eduardo; Velasco, Eladio A; Caldés, Trinidad; de la Hoya, Miguel


    Rare sequence variants in "high-risk" disease genes, often referred as unclassified variants (UVs), pose a serious challenge to genetic testing. However, UVs resulting in splicing alterations can be readily assessed by in vitro assays. Unfortunately, analytical and clinical interpretation of these assays is often challenging. Here, we explore this issue by conducting splicing assays in 31 BRCA2 genetic variants. All variants were assessed by RT-PCR followed by capillary electrophoresis and direct sequencing. If assays did not produce clear-cut outputs (Class-2 or Class-5 according to analytical International Agency for Research on Cancer guidelines), we performed qPCR and/or minigene assays. The latter were performed with a new splicing vector (pSAD) developed by authors of the present manuscript (patent #P201231427 CSIC). We have identified three clinically relevant Class-5 variants (c.682-2A>G, c.7617+1G>A, and c.8954-5A>G), and 27 analytical Class-2 variants (not inducing splicing alterations). In addition, we demonstrate that rs9534262 (c.7806-14T>C) is a BRCA2 splicing quantitative trait locus.

  14. Analytical strategies for phosphoproteomics

    DEFF Research Database (Denmark)

    Thingholm, Tine E; Jensen, Ole N; Larsen, Martin R


    sensitive and specific strategies. Today, most phosphoproteomic studies are conducted by mass spectrometric strategies in combination with phospho-specific enrichment methods. This review presents an overview of different analytical strategies for the characterization of phosphoproteins. Emphasis...... will be on the affinity methods utilized specifically for phosphoprotein and phosphopeptide enrichment prior to MS analysis, and on recent applications of these methods in cell biological applications....

  15. Mapping the indentation between the Iberian and Eurasian plates beneath the Western Pyrenees/Eastern Cantabrian Mountains from receiver function analysis (United States)

    Díaz, J.; Pedreira, D.; Ruiz, M.; Pulgar, J. A.; Gallart, J.


    In the last decades, active seismic profiling in the northern part of the Iberian Peninsula has evidenced that the Alpine collision between the Iberian and Eurasian plates resulted in a complex crustal structure, with the Iberian crust underthrusting the Eurasian crust and reaching depths of at least 45-50 km beneath the Pyrenean chain and the Cantabrian Mountains. In the transition between these two zones the situation is particularly complex, as evidenced in previous wide-angle and passive seismic studies. This contribution focuses in getting new clues on the crustal structure of this transitional zone through receiver function (RF) analysis of teleseismic data recorded at permanent and temporary stations located in both the Spanish and French sides of the Western Pyrenees. Different techniques (H-κ stacking, pseudo-migration, synthetic 2D modeling) have been considered in the analysis. Passive seismic data from previous temporary deployments in the zone have been reworked and added to the discussion. A first order result is that passive seismic data are broadly consistent with the indentation of the Iberian and Eurasian crusts inferred from active seismic profiling, thus providing a completely independent confirmation of this feature. For the first time, an Iberian Moho underlying the Eurasian crust is documented from RF beneath the stations located at the Northern side of the Pyrenean range. Moreover, clear indications of dipping interfaces are observed at some stations. The new RF results suggest that in the crustal indentation beneath the Basque Massifs area, the Eurasian crust extends farther south with respect to the image inferred from active seismic data. This new geometry implies that the Pamplona transfer zone has played a major role in the regional geodynamic history.

  16. Schizophrenia symptoms and functioning in patients receiving long-term treatment with olanzapine long-acting injection formulation: a pooled analysis

    Directory of Open Access Journals (Sweden)

    Peuskens Joseph


    Full Text Available Abstract Background This analysis of pooled data evaluates treatment outcomes of patients with schizophrenia receiving maintenance treatment with olanzapine long-acting injection (OLAI by means of a categorical approach addressing the symptomatic and functional status of patients at different times. Methods Patients were grouped into 5 categories at baseline, 6 months, and 12 months. Shifts between categories were assessed for individual patients and factors associated with improvement were analyzed. 1182 patients from 3 clinical trials were included in the current analysis. Results At baseline, 434 (36.8% patients had minimal Positive and Negative Syndrome Scale (PANSS symptoms but seriously impaired Heinrich Carpenter’s Quality of Life Scale (QLS functioning; 303 (25.6% had moderate to severe symptoms and seriously impaired function; 208 (17.6% had mild to moderate symptoms but good functioning, and 162 (13.7% had minimal symptoms and good functioning. Baseline category was significantly associated with Clinical Global Impression – Severity (CGI-S, extrapyramidal symptoms, working status, age, and number of previous episodes. The majority of all patients starting OLAI treatment maintained or improved (62% at 6 months and 52% at 12 months their symptom and functioning levels on OLAI maintenance treatment. Less than 8% of the patients showed worsening of symptoms or functioning. An improvement in category was associated with high PANSS positive and low CGI-S scores at baseline. Conclusions We present evidence that a composite assessment of schizophrenic patients including symptom severity and functioning is helpful in the evaluation of maintenance treatment outcomes. This approach could also be useful for the assessment of treatment options in clinical practice. The trials from which data are reported here were registered on as NCT00088491, NCT00088465, and NCT00320489.

  17. Comparative effects of different enteral feeding methods in head and neck cancer patients receiving radiotherapy or chemoradiotherapy: a network meta-analysis

    Directory of Open Access Journals (Sweden)

    Zhang ZH


    Full Text Available Zhihong Zhang,1,2 Yu Zhu,1 Yun Ling,3 Lijuan Zhang,1 Hongwei Wan1 1Department of Nursing, Shanghai Proton and Heavy Ion Center, 2Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, 3Department of Human Resource, Shanghai Proton and Heavy Ion Center, Shanghai, People’s Republic of China Abstract: Nasogastric tube (NGT and percutaneous endoscopic gastrostomy were frequently used in the head and neck cancer patients when malnutrition was present. Nevertheless, the evidence was inclusive in terms of the choice and the time of tube placement. The aim of this network meta-analysis was to evaluate the comparative effects of prophylactic percutaneous endoscopic gastrostomy (pPEG, reactive percutaneous endoscopic gastrostomy (rPEG, and NGT in the head and neck cancer patients receiving radiotherapy or chemoradiotherapy. Databases of PubMed, Web of Science, and Elsevier were searched from inception to October 2015. Thirteen studies enrolling 1,631 participants were included in this network meta-analysis. The results indicated that both pPEG and NGT were superior to rPEG in the management of weight loss. pPEG was associated with the least rate of treatment interruption and nutrition-related hospital admission among pPEG, rPEG, and NGT. Meanwhile, there was no difference in tube-related complications. Our study suggested that pPEG might be a better choice in malnutrition management in the head and neck cancer patients undergoing radiotherapy or chemoradiotherapy. However, its effects need to be further investigated in more randomized controlled trials. Keywords: malnutrition, tube feeding, weight loss, treatment interruption, readmission, complication

  18. Determination of optimal PTV margin for patients receiving CBCT-guided prostate IMRT: comparative analysis based on CBCT dose calculation with four different margins. (United States)

    Gill, Sukhdeep K; Reddy, Krishna; Campbell, Nina; Chen, Changhu; Pearson, David


    Variations in daily setup and rectum/bladder filling lead to uncertainties in the delivery of prostate IMRT. The purpose of this study is to determine the optimal PTV margin for CBCT-guided prostate IMRT based on daily CBCT dose calculations using four different margins. Five patients diagnosed with low-risk prostate cancer were treated with prostate IMRT to 70 Gy in 28 fractions using daily CBCT for image guidance. The prostate CTV and OARs were contoured on all CBCTs. IMRT plans were created using 1 mm, 3 mm, 5 mm, and 7 mm CTV to PTV expansions. For each delivered fraction, dose calculations were generated utilizing the pretreatment CBCT translational shifts performed and dosimetric analysis was performed. One hundred and forty total treatment fractions (CBCT sessions) were evaluated. The planned prostate CTV V100% was 100% for all PTV margins. Based on CBCT analysis, the actual cumulative CTVs V100% were 96.55% ± 2.94%, 99.49% ± 1.36%, 99.98% ± 0.26%, and 99.99% ± 0.05% for 1, 3, 5, and 7 mm uniform PTV margins, respectively. Delivered rectum and bladder doses were different as compared to expected planned doses, with the magnitude of differences increasing with PTV margin. Daily setup variation during prostate IMRT yields differences in the actual vs. expected doses received by the prostate CTV, rectum, and bladder. The magnitude of these differences is significantly affected by the PTV margin utilized. It was found that when daily CBCT was used for soft-tissue alignment of the prostate, a 3 mm PTV margin allowed for CTV to be covered for 99% of cases.

  19. Correction methodology for the spectral interfering {gamma}-rays overlapping to the analytical peaks used in the analysis of {sup 232}Th

    Energy Technology Data Exchange (ETDEWEB)

    Yuecel, H., E-mail: [Institute of Nuclear Sciences, Ankara University (Australia), Besevler Yerleskesi, Tandogan, 06100 Ankara (Turkey); Koese, E. [Institute of Nuclear Sciences, Ankara University (Australia), Besevler Yerleskesi, Tandogan, 06100 Ankara (Turkey); Esen, A.N. [Energy Institute, Istanbul Technical University (ITU), Maslak, 34469 Istanbul (Turkey); Bor, D. [Institute of Nuclear Sciences, Ankara University (Australia), Besevler Yerleskesi, Tandogan, 06100 Ankara (Turkey)


    In the {gamma}-ray spectrometric analysis of the radionuclides, a correction factor is generally required for the spectral interfering {gamma}-rays in determining the net areas of the analytical peaks because some interfering {gamma}-rays often might contribute to the analytical peaks of interest. In present study, a correction methodology for the spectral interfering {gamma}-rays (CSI) is described. In particular, in the analysis of {sup 232}Th contained in samples, the interfering {gamma}-rays due to {sup 226}Ra, {sup 235}U, {sup 238}U and their decay products often overlap to the peaks of interest from {sup 232}Th decay products, and vise versa. For the validation of the proposed CSI method, several certified reference materials (CRM) containing U and Th were measured by using a 76.5% efficient n-type Ge detector. The required correction factors were quantified for spectral interference, self-absorption and true coincidence summing (TCS) effects for the relevant {gamma}-rays. The measured results indicate that if one ignores the contributions of the interfering {gamma}-rays to the analytical peaks at 583.2 keV of {sup 208}Tl and 727.3 keV of {sup 212}Bi, this leads to a significantly systematic influence on the resulted activities of {sup 232}Th. The correction factors required for spectral interference and TCS effects are estimated to be {approx}13.6% and {approx}15.4% for 583.2 keV peak. For the 727.3 keV peak, the correction factor is estimated to be {approx}15% for spectral interference, and {approx}5% for the TCS effects at the presently used detection geometry. On the other hand, the measured results also indicate that ignoring the contribution of the interfering {gamma}-rays to the areas of the analytical peaks at 860.6 keV of {sup 208}Tl, 338.3 and 911.2 keV of {sup 228}Ac does not lead to any significant systematic influence on the {sup 232}Th analysis. Because these factors are remained generally less than {approx}5%, i.e., within overall uncertainty

  20. Analysis and Trend Determination of the Evolution of Tourist Accommodation Establishments (Adjusted Data Based Seasonally in the European Union (28 with Analytical Methods

    Directory of Open Access Journals (Sweden)

    Rodica Pripoaie


    Full Text Available This work presents the comparative analysis and trend determination of the evolution tourist accommodation establishments in the European Union (28, adjusted data based seasonally, in the period May 2014 - December 2014 used the Analytical Methods. The principal causes of the evolution tourist accommodation establishments were: the general economic evolution of industries and GDP per capita, the relatively low revenue or low development of the infrastructure. Trend determination of the evolution tourist accommodation establishments in the European Union (28 with analytical methods requires least squares method. On the base the results of the absolute deviations between empirical and theoretical values for the linear, curvilinear and modified exponential regression, will choose the best trend equation for the smallest variation. The best trend model for evolution tourist accommodation establishments in EU (28 is modelled using linear regression equation.

  1. Performance analysis of junctionless double gate VeSFET considering the effects of thermal variation - An explicit 2D analytical model (United States)

    Chaudhary, Tarun; Khanna, Gargi


    The purpose of this paper is to explore junctionless double gate vertical slit field effect transistor (JLDG VeSFET) with reduced short channel effects and to develop an analytical threshold voltage model for the device considering the impact of thermal variations for the very first time. The model has been derived by solving 2D Poisson's equation and the effects of variation in temperature on various electrical parameters of the device such as Rout, drain current, mobility, subthreshold slope and DIBL has been studied and described in the paper. The model provides a deep physical insight of the device behavior and is also very helpful in contributing to the design space exploration for JLDG VeSFET. The proposed model is verified with simulative analysis at different radii of the device and it has been observed that there is a good agreement between the analytical model and simulation results.

  2. Banach spaces of analytic functions

    CERN Document Server

    Hoffman, Kenneth


    A classic of pure mathematics, this advanced graduate-level text explores the intersection of functional analysis and analytic function theory. Close in spirit to abstract harmonic analysis, it is confined to Banach spaces of analytic functions in the unit disc.The author devotes the first four chapters to proofs of classical theorems on boundary values and boundary integral representations of analytic functions in the unit disc, including generalizations to Dirichlet algebras. The fifth chapter contains the factorization theory of Hp functions, a discussion of some partial extensions of the f

  3. Multidimensional integral representations problems of analytic continuation

    CERN Document Server

    Kytmanov, Alexander M


    The monograph is devoted to integral representations for holomorphic functions in several complex variables, such as Bochner-Martinelli, Cauchy-Fantappiè, Koppelman, multidimensional logarithmic residue etc., and their boundary properties. The applications considered are problems of analytic continuation of functions from the boundary of a bounded domain in C^n. In contrast to the well-known Hartogs-Bochner theorem, this book investigates functions with the one-dimensional property of holomorphic extension along complex lines, and includes the problems of receiving multidimensional boundary analogs of the Morera theorem.   This book is a valuable resource for specialists in complex analysis, theoretical physics, as well as graduate and postgraduate students with an understanding of standard university courses in complex, real and functional analysis, as well as algebra and geometry.

  4. Analytical Quality by Design in pharmaceutical quality assurance: Development of a capillary electrophoresis method for the analysis of zolmitriptan and its impurities. (United States)

    Orlandini, Serena; Pasquini, Benedetta; Caprini, Claudia; Del Bubba, Massimo; Pinzauti, Sergio; Furlanetto, Sandra


    A fast and selective CE method for the determination of zolmitriptan (ZOL) and its five potential impurities has been developed applying the analytical Quality by Design principles. Voltage, temperature, buffer concentration, and pH were investigated as critical process parameters that can influence the critical quality attributes, represented by critical resolution values between peak pairs, analysis time, and peak efficiency of ZOL-dimer. A symmetric screening matrix was employed for investigating the knowledge space, and a Box-Behnken design was used to evaluate the main, interaction, and quadratic effects of the critical process parameters on the critical quality attributes. Contour plots were drawn highlighting important interactions between buffer concentration and pH, and the gained information was merged into the sweet spot plots. Design space (DS) was established by the combined use of response surface methodology and Monte Carlo simulations, introducing a probability concept and thus allowing the quality of the analytical performances to be assured in a defined domain. The working conditions (with the interval defining the DS) were as follows: BGE, 138 mM (115-150 mM) phosphate buffer pH 2.74 (2.54-2.94); temperature, 25°C (24-25°C); voltage, 30 kV. A control strategy was planned based on method robustness and system suitability criteria. The main advantages of applying the Quality by Design concept consisted of a great increase of knowledge of the analytical system, obtained throughout multivariate techniques, and of the achievement of analytical assurance of quality, derived by probability-based definition of DS. The developed method was finally validated and applied to the analysis of ZOL tablets.

  5. Wideband CMOS receivers

    CERN Document Server

    Oliveira, Luis


    This book demonstrates how to design a wideband receiver operating in current mode, in which the noise and non-linearity are reduced, implemented in a low cost single chip, using standard CMOS technology.  The authors present a solution to remove the transimpedance amplifier (TIA) block and connect directly the mixer’s output to a passive second-order continuous-time Σ∆ analog to digital converter (ADC), which operates in current-mode. These techniques enable the reduction of area, power consumption, and cost in modern CMOS receivers.


    Directory of Open Access Journals (Sweden)

    Ekaterina Viktorovna Medvedeva


    Full Text Available Analytical approaches to research of export operations depend on the conditions containing in separate external economic contracts with foreign buyers and also on a form of an exit of the Russian supplier of export goods to a foreign market. By means of analytical procedures it is possible to foresee and predict admissible situations which can have an adverse effect on a financial position of the economic subject. The economic entity, the engaged foreign economic activity, has to carry out surely not only the analysis of the current activity, but also the analysis of export operations. In article analytical approaches of carrying out the analysis of export operations are considered, on an example the analysis of export operations in dynamics is submitted, it is recommended to use the formulas allowing to estimate export in dynamics. For the comparative analysis export volume in the comparable prices is estimated. On the commodity groups including and quantitatively and qualitatively commensurable goods, the index of quantitative structure is calculated, the coefficient of delay of delivery of goods in comparison with other periods pays off. Carrying out the analysis allows to determine a tendency of change of export deliveries by export operations for the analyzed period for adoption of administrative decisions.Purpose Definition of the ways and receptions of the analysis applying when carrying out the analysis of export operations.Methodology in article economic-mathematical methods, and also statistical methods of the analysis were used.Results: the most informative parameters showing some aspects of carrying out the analysis of export operations are received.Practical implications it is expedient to apply the received results the economic subjects which are carrying out foreign economic activity, one of which elements are export operations.

  7. 学习分析主题结构研究及可视化分析%Topic Structure and Visualization Analysis of Learning Analytics Research

    Institute of Scientific and Technical Information of China (English)

    黄志南; 陆星儿; 胡贺宁; 李艳燕


    As an important part ofeducational data mining,learning analytics has drawn extensive attention among international scholars since its origin.To further explore the research on learning analytics,this paper,based on 674 articles on learning analytics between 2010 and 2015 from Web ofScience,explored and revealed the international re-search status about learning analytics. In this study,we used the “Bicomb”word frequency analysis software,the “Citespace”citation analysis tool and “SCI2”tool and visualization technology to analyze the high-cited articles,the distribution ofcore authors,high prolific institutions and high frequency keywords.In addition,based on dissimilarity matrix ofhigh frequency key-words,this paper further clarified the research scope using cluster analysis.Furthermore,by mapping out the strategic diagram graph,the trend ofthe development orientation oflearning analytics was further clarified in order to provide reference and suggestions for international research and practices on learning analytics. Results showed that the research topics had been greatly expanded and were more abundant during the 2011-2014 period.The learning analytics on behalfofcommunities suddenly rose and ranked to the top for four years,which made it the hottest research area during those period oftimes.Learning analytics showed an increasing trend year by year,mainly related to information retrieval and education data mining.While,there is a split phenomenon ofthe visual analytics.It has two successors involving “Visual analytics”and “Machine learning”,respectively as the repre-sentative ofthe theme.The two successors with the learning analytics become the three core research hotspots in 2015. From the results ofthe study,we can conclude that the learning analytics technology is still in the initial stage and the field ofresearch is not balanced.Learning analytics research also face many challenges concerning data secur-ity,ethics,and privacy. In

  8. Semi-Analytical Modeling and Analysis in Three Dimensions of the Optical Carrier Injection and Diffusion in a Semiconductor Substrate (United States)

    Gary, René; Arnould, Jean-Daniel; Vilcot, Anne


    In order to be faster and more precise than any numerical technique for the computation of the photo-induced plasma in semiconductor, an analytical solution has to be developed. In this paper, the Hankel transform is used to simplify the solution of the differential equation of second order with nonconstant coefficient, known as the diffusion equation. The resulting expression of the three-dimensional (3-D) carrier density includes all the physical parameters of the substrate and the laser beam as well. A parametric study was also feasible using the developed expressions.

  9. A reproducible analytical system based on the multi-component analysis of triterpene acids in Ganoderma lucidum. (United States)

    Da, Juan; Cheng, Chun-Ru; Yao, Shuai; Long, Hua-Li; Wang, Yan-Hong; Khan, Ikhlas A; Li, Yi-Feng; Wang, Qiu-Rong; Cai, Lu-Ying; Jiang, Bao-Hong; Liu, Xuan; Wu, Wan-Ying; Guo, De-An


    Ultra-performance liquid chromatography (UPLC) and Single Standard for Determination of Multi-Components (SSDMC) are becoming increasingly important for quality control of medicinal herbs; this approach was developed for Ganoderma lucidum. Special attention was necessary for the appropriate selection of markers, for determining the reproducibility of the relative retention times (RRT), and for the accuracy of conversion factors (F). Finally, ten components were determined, with ganoderic acid A serving as single standard. Stable system parameters were established, and with successful resolution of those issues, this analytical method could be used more broadly.

  10. Analytical chemistry in space

    CERN Document Server

    Wainerdi, Richard E


    Analytical Chemistry in Space presents an analysis of the chemical constitution of space, particularly the particles in the solar wind, of the planetary atmospheres, and the surfaces of the moon and planets. Topics range from space engineering considerations to solar system atmospheres and recovered extraterrestrial materials. Mass spectroscopy in space exploration is also discussed, along with lunar and planetary surface analysis using neutron inelastic scattering. This book is comprised of seven chapters and opens with a discussion on the possibilities for exploration of the solar system by

  11. Analytic device including nanostructures

    KAUST Repository

    Di, Fabrizio, E.


    A device for detecting an analyte in a sample comprising: an array including a plurality of pixels, each pixel including a nanochain comprising: a first nanostructure, a second nanostructure, and a third nanostructure, wherein size of the first nanostructure is larger than that of the second nanostructure, and size of the second nanostructure is larger than that of the third nanostructure, and wherein the first nanostructure, the second nanostructure, and the third nanostructure are positioned on a substrate such that when the nanochain is excited by an energy, an optical field between the second nanostructure and the third nanostructure is stronger than an optical field between the first nanostructure and the second nanostructure, wherein the array is configured to receive a sample; and a detector arranged to collect spectral data from a plurality of pixels of the array.

  12. Quantitative and Qualitative Analysis of Aconitum Alkaloids in Raw and Processed Chuanwu and Caowu by HPLC in Combination with Automated Analytical System and ESI/MS/MS

    Directory of Open Access Journals (Sweden)

    Aimin Sun


    Full Text Available HPLC in combination with automated analytical system and ESI/MS/MS was used to analyze aconitine (A, mesaconitine (MA, hypaconitine (HA, and their benzoyl analogs in the Chinese herbs Caowu and Chuanwu. First, an HPLC method was developed and validated to determine A, MA, and HA in raw and processed Caowu and Chuanwu. Then an automated analytical system and ESI/MS/MS were applied to analyze these alkaloids and their semihydrolyzed products. The results obtained from automated analytical system are identical to those from ESI/MS/MS, which indicated that the method is a convenient and rapid tool for the qualitative analysis of herbal preparations. Furthermore, HA was little hydrolyzed by heating processes and thus it might account more for the toxicity of processed aconites. Hence, HA could be used as an indicator when one alkaloid is required as a reference to monitor the quality of raw and processed Chuanwu and Caowu. In addition, the raw and processed Chuanwu and Caowu can be distinguished by monitoring the ratio of A and MA to HA.

  13. Development and optimization of an analytical system for volatile organic compound analysis coming from the heating of interstellar/cometary ice analogues. (United States)

    Abou Mrad, Ninette; Duvernay, Fabrice; Theulé, Patrice; Chiavassa, Thierry; Danger, Grégoire


    This contribution presents an original analytical system for studying volatile organic compounds (VOC) coming from the heating and/or irradiation of interstellar/cometary ice analogues (VAHIIA system) through laboratory experiments. The VAHIIA system brings solutions to three analytical constraints regarding chromatography analysis: the low desorption kinetics of VOC (many hours) in the vacuum chamber during laboratory experiments, the low pressure under which they sublime (10(-9) mbar), and the presence of water in ice analogues. The VAHIIA system which we developed, calibrated, and optimized is composed of two units. The first is a preconcentration unit providing the VOC recovery. This unit is based on a cryogenic trapping which allows VOC preconcentration and provides an adequate pressure allowing their subsequent transfer to an injection unit. The latter is a gaseous injection unit allowing the direct injection into the GC-MS of the VOC previously transferred from the preconcentration unit. The feasibility of the online transfer through this interface is demonstrated. Nanomoles of VOC can be detected with the VAHIIA system, and the variability in replicate measurements is lower than 13%. The advantages of the GC-MS in comparison to infrared spectroscopy are pointed out, the GC-MS allowing an unambiguous identification of compounds coming from complex mixtures. Beyond the application to astrophysical subjects, these analytical developments can be used for all systems requiring vacuum/cryogenic environments.


    Directory of Open Access Journals (Sweden)



    Full Text Available In this paper, we analyzed OSNR and received electric RF power of a RoF communication system having variable fiber length, using direct and external modulation techniques and different optical amplifiers. In this work, we have compared and measured the OSNR and received optical power of the RoF system for different modulation techniques, i.e. direct and external modulation. Further, we also compared the received electric RF power for variable fiber lengths for direct and external modulation using different optical amplifiers, i.e. EDFAand SOA. We observe an increase of –11 dB (approx. in the received RF power for External modulation compared to direct modulation with EDFA.

  15. Effectiveness of Cognitive Behavioral Therapy for Depression in Patients Receiving Disability Benefits: A Systematic Review and Individual Patient Data Meta-Analysis

    NARCIS (Netherlands)

    S. Ebrahim (Shanil); L. Montoya (Luis); W. Truong (Wanda); S. Hsu (Sandy); M. Kamal el Din (Mostafa); A. Carrasco-Labra (Alonso); J.W. Busse (Jason); S.D. Walter (Stephen); D. Heels-Ansdell (Diane); R. Couban (Rachel); I. Patelis-Siotis (Irene); M. Bellman (Marg); L.E. de Graaf (Esther); D.J.A. Dozois (David); P.J. Bieling (Peter); G.H. Guyatt (Gordon)


    textabstractObjectives: To systematically summarize the randomized trial evidence regarding the relative effectiveness of cognitive behavioural therapy (CBT) in patients with depression in receipt of disability benefits in comparison to those not receiving disability benefits. Data Sources: All rele

  16. Zero-power receiver

    Energy Technology Data Exchange (ETDEWEB)

    Brocato, Robert W.


    An unpowered signal receiver and a method for signal reception detects and responds to very weak signals using pyroelectric devices as impedance transformers and/or demodulators. In some embodiments, surface acoustic wave devices (SAW) are also used. Illustrative embodiments include satellite and long distance terrestrial communications applications.

  17. Analysis of aflatoxins in traditional Chinese medicines: Classification of analytical method on the basis of matrix variations. (United States)

    Zhao, Sheng-Ping; Zhang, Dan; Tan, Li-Hong; Yu, Bao; Cao, Wei-Guo


    A classification system for analytical methods was developed for the first time to determine the presence of aflatoxins B1, B2, G1 and G2 in traditional Chinese medicines (TCMs) based on different matrix types using ultra-performance liquid chromatography-tandem mass spectrometry. A useful characteristic of the approach was that the TCMs could be systematically divided into four categories (i.e., volatile oils, proteins, polysaccharides and fatty oils) depending on the matrix types. The approach concluded that different types of TCMs required different optimal sample preparation procedures. Based on the optimized analytical conditions, the limits of detection and quantification, average recoveries and linearity of four aflatoxins were determined and conformed to research limits. Of 22 TCMs samples, 14 samples were contaminated with at least one type aflatoxin at concentrations ranging from 0.2 to 7.5 μg/kg, and the average contents of aflatoxins were significantly different for the different matrix types. Moreover, we found a potential link between the contamination levels of aflatoxins and matrix types. TCMs containing fatty oils were the most susceptible to contamination by aflatoxins and followed by TCMs containing polysaccharides and proteins; TCMs containing abundant amounts of volatile oils were less prone to contamination.

  18. Analysis of magnesium from magnesium stearate in pharmaceutical tablet formulations using hydrophilic interaction liquid chromatography with nano quantity analyte detection. (United States)

    Risley, Donald S; Magnusson, Lars-Erik; Morow, Paul R; Aburub, Aktham


    This study demonstrates the use of hydrophilic interaction liquid chromatography with a nano quantity analyte detector for the retention, separation and detection of magnesium from magnesium stearate in tablet formulations for a drug product formulation blend containing a hydrochloride salt of a weakly basic compound as the active ingredient. The nano quantity analyte detector can provide direct detection of inactive excipients and inorganic salts lacking ultraviolet chromophores, as well as, all non-volatile compounds. The separation was accomplished using a SeQuant ZIC-HILIC column and mobile phase consisting of 32.5:32.5:35 of acetone/methanol/ammonium formate buffer (150 mM, pH 4.5). Common validation parameters were evaluated to assess the method's quantitative potential for magnesium (from magnesium stearate) including: linearity, accuracy, specificity, solution stability, repeatability, and intermediate precision. Overall, the method described in this report proved to be very robust and represents a novel technique to conveniently separate and detect magnesium from magnesium stearate in pharmaceutical preparations both quickly and accurately.

  19. A comparison of 1D analytical model and 3D finite element analysis with experiments for a rosen-type piezoelectric transformer. (United States)

    Boukazouha, F; Poulin-Vittrant, G; Tran-Huu-Hue, L P; Bavencoffe, M; Boubenider, F; Rguiti, M; Lethiecq, M


    This article is dedicated to the study of Piezoelectric Transformers (PTs), which offer promising solutions to the increasing need for integrated power electronics modules within autonomous systems. The advantages offered by such transformers include: immunity to electromagnetic disturbances; ease of miniaturisation for example, using conventional micro fabrication processes; and enhanced performance in terms of voltage gain and power efficiency. Central to the adequate description of such transformers is the need for complex analytical modeling tools, especially if one is attempting to include combined contributions due to (i) mechanical phenomena owing to the different propagation modes which differ at the primary and secondary sides of the PT; and (ii) electrical phenomena such as the voltage gain and power efficiency, which depend on the electrical load. The present work demonstrates an original one-dimensional (1D) analytical model, dedicated to a Rosen-type PT and simulation results are successively compared against that of a three-dimensional (3D) Finite Element Analysis (COMSOL Multiphysics software) and experimental results. The Rosen-type PT studied here is based on a single layer soft PZT (P191) with corresponding dimensions 18 mm × 3 mm × 1.5 mm, which operated at the second harmonic of 176 kHz. Detailed simulational and experimental results show that the presented 1D model predicts experimental measurements to within less than 10% error of the voltage gain at the second and third resonance frequency modes. Adjustment of the analytical model parameters is found to decrease errors relative to experimental voltage gain to within 1%, whilst a 2.5% error on the output admittance magnitude at the second resonance mode were obtained. Relying on the unique assumption of one-dimensionality, the present analytical model appears as a useful tool for Rosen-type PT design and behavior understanding.

  20. Green analytical chemistry--theory and practice. (United States)

    Tobiszewski, Marek; Mechlińska, Agata; Namieśnik, Jacek


    This tutorial review summarises the current state of green analytical chemistry with special emphasis on environmentally friendly sample preparation techniques. Green analytical chemistry is a part of the sustainable development concept; its history and origins are described. Miniaturisation of analytical devices and shortening the time elapsing between performing analysis and obtaining reliable analytical results are important aspects of green analytical chemistry. Solventless extraction techniques, the application of alternative solvents and assisted extractions are considered to be the main approaches complying with green analytical chemistry principles.