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Sample records for analytic receiver analysis

  1. Exploratory Analysis in Learning Analytics

    Science.gov (United States)

    Gibson, David; de Freitas, Sara

    2016-01-01

    This article summarizes the methods, observations, challenges and implications for exploratory analysis drawn from two learning analytics research projects. The cases include an analysis of a games-based virtual performance assessment and an analysis of data from 52,000 students over a 5-year period at a large Australian university. The complex…

  2. Optimal Analytical Solution for a Capacitive Wireless Power Transfer System with One Transmitter and Two Receivers

    Directory of Open Access Journals (Sweden)

    Ben Minnaert

    2017-09-01

    Full Text Available Wireless power transfer from one transmitter to multiple receivers through inductive coupling is slowly entering the market. However, for certain applications, capacitive wireless power transfer (CWPT using electric coupling might be preferable. In this work, we determine closed-form expressions for a CWPT system with one transmitter and two receivers. We determine the optimal solution for two design requirements: (i maximum power transfer, and (ii maximum system efficiency. We derive the optimal loads and provide the analytical expressions for the efficiency and power. We show that the optimal load conductances for the maximum power configuration are always larger than for the maximum efficiency configuration. Furthermore, it is demonstrated that if the receivers are coupled, this can be compensated for by introducing susceptances that have the same value for both configurations. Finally, we numerically verify our results. We illustrate the similarities to the inductive wireless power transfer (IWPT solution and find that the same, but dual, expressions apply.

  3. Receiver operator characteristic (ROC) analysis without truth

    International Nuclear Information System (INIS)

    Henkelman, R.M.; Kay, I.; Bronskill, M.J.

    1990-01-01

    Receiver operator characteristic (ROC) analysis, the preferred method of evaluating diagnostic imaging tests, requires an independent assessment of the true state of disease, which can be difficult to obtain and is often of questionable accuracy. A new method of analysis is described which does not require independent truth data and which can be used when several accurate tests are being compared. This method uses correlative information to estimate the underlying model of multivariate normal distributions of disease-positive and disease-negative patients. The method is shown to give results equivalent to conventional ROC analysis in a comparison of computed tomography, radionuclide scintigraphy, and magnetic resonance imaging for liver metastasis. When independent truth is available, the method can be extended to incorporate truth data or to evaluate the consistency of the truth data with the imaging data

  4. Receive-Noise Analysis of Capacitive Micromachined Ultrasonic Transducers.

    Science.gov (United States)

    Bozkurt, Ayhan; Yaralioglu, G Goksenin

    2016-11-01

    This paper presents an analysis of thermal (Johnson) noise received from the radiation medium by otherwise noiseless capacitive micromachined ultrasonic transducer (CMUT) membranes operating in their fundamental resonance mode. Determination of thermal noise received by multiple numbers of transducers or a transducer array requires the assessment of cross-coupling through the radiation medium, as well as the self-radiation impedance of the individual transducer. We show that the total thermal noise received by the cells of a CMUT has insignificant correlation, and is independent of the radiation impedance, but is only determined by the mass of each membrane and the electromechanical transformer ratio. The proof is based on the analytical derivations for a simple transducer with two cells, and extended to transducers with numerous cells using circuit simulators. We used a first-order model, which incorporates the fundamental resonance of the CMUT. Noise power is calculated by integrating over the entire spectrum; hence, the presented figures are an upper bound for the noise. The presented analyses are valid for a transimpedance amplifier in the receive path. We use the analysis results to calculate the minimum detectable pressure of a CMUT. We also provide an analysis based on the experimental data to show that output noise power is limited by and comparable to the theoretical upper limit.

  5. Analysis of signal acquisition in GPS receiver software

    Directory of Open Access Journals (Sweden)

    Vlada S. Sokolović

    2011-01-01

    . the whole receiver is software implemented in a MATLAB software package. One of the processes during the signal processing is the initial synchronization (acquisition, where a signal is detected and the carrier frequency is determined as well as the phase sequence code and the carrier Doppler frequency. The acquisition aim is to determine, in the shortest time possible, the parameters of the detected signals and forward them to the next block in synchronization. Depending on the speed and accuracy of the signal parameter determination, different methods of acquisition are applied in practice. The paper presents the methods of serial, parallel and cyclic convolution. For comparison purposes, the architectures of signal processing of particular methods for implementation in receiver software are shown. All measurements were performed on the same signal under the same conditions. On the basis of the tests performed, a detailed analysis of the collected data was carried out and the most acceptable acquisition method for implementation in software GPS receiver was proposed. Because of a relatively high level of noise at the receiver entrance and the received signal interference, the comparison of the results has been done on the basis of the analytical results and the mean time of signal synchronization. The measurement results are shown in tables for easy comparison. The results of measurements using the proposed method are presented as well. The technology of receiver software allows the user to access easily to the architecture of the receiver and therefore allows a simple change of parameters. The influence of the parameters on the process of signal acquisition is also shown in the paper. The graphic presentation shows how and to what extent some of the parameters affect the process of the receiver signal processing. All listed acquisition methods are used in practice. The proposed method is the most suitable for application in software receivers. Based on the analysis

  6. Double-contained receiver tank 244-TX, grab samples, 244TX-97-1 through 244TX-97-3 analytical results for the final report

    International Nuclear Information System (INIS)

    Esch, R.A.

    1997-01-01

    This document is the final report for the double-contained receiver tank (DCRT) 244-TX grab samples. Three grabs samples were collected from riser 8 on May 29, 1997. Analyses were performed in accordance with the Compatibility Grab Sampling and Analysis Plan (TSAP) and the Data Quality Objectives for Tank Farms Waste Compatibility Program (DQO). The analytical results are presented in a table

  7. Analytical analysis of the CELIV theory

    Energy Technology Data Exchange (ETDEWEB)

    Lorrmann, Jens; Deibel, Carsten [Experimental Physics VI, Physical Institute, Julius-Maximilians University of Wuerzburg (Germany); Badada, Bekele Homa; Inganaes, Olle [Biomolecular and Organic Electronics, IFM, Linkoeping University (Sweden); Dyakonov, Vladimir [Experimental Physics VI, Physical Institute, Julius-Maximilians University of Wuerzburg (Germany); ZAE Bayern, Div. Functional Materials for Energy Technology, Wuerzburg (Germany)

    2010-07-01

    Charge extraction by linearly increasing voltage (CELIV) has attracted much interest in organic semiconductor research, due to its feature of measuring charge carrier mobility and density directly and simultaneously. Up to now the theoretical description of this method has been solved for a low mobility approximation only, because the general solution was impeded by a Ricatti type first order differential equation. In this contribution we present the analytical solution for this Ricatti equation, thus completing the analytical framework of the CELIV method. We compare it with the approximated theory and show that especially for standard organic solar cell materials the low mobility approach is hardly valid. The evaluation of photo-CELIV measurements on poly(3-hexyl thiophene-2,5-diyl):[6,6]-phenyl-C{sub 61} butyric acid methyl ester solar cells can then be done by fitting the current transients. Surprisingly the fit results are only in a good agreement with the experimental currents, if two extraction currents are taken into account - the origin of which we will discuss. Furthermore we present a new equation for mobility evaluation from numerical analysis within our framework, which can be applied over the entire experimental range.

  8. Asymmetric Hardware Distortions in Receive Diversity Systems: Outage Performance Analysis

    KAUST Repository

    Javed, Sidrah

    2017-02-22

    This paper studies the impact of asymmetric hardware distortion (HWD) on the performance of receive diversity systems using linear and switched combining receivers. The asymmetric attribute of the proposed model motivates the employment of improper Gaussian signaling (IGS) scheme rather than the traditional proper Gaussian signaling (PGS) scheme. The achievable rate performance is analyzed for the ideal and non-ideal hardware scenarios using PGS and IGS transmission schemes for different combining receivers. In addition, the IGS statistical characteristics are optimized to maximize the achievable rate performance. Moreover, the outage probability performance of the receive diversity systems is analyzed yielding closed form expressions for both PGS and IGS based transmission schemes. HWD systems that employ IGS is proven to efficiently combat the self interference caused by the HWD. Furthermore, the obtained analytic expressions are validated through Monte-Carlo simulations. Eventually, non-ideal hardware transceivers degradation and IGS scheme acquired compensation are quantified through suitable numerical results.

  9. Analysis of the WindSat Receiver Frequency Passbands

    Science.gov (United States)

    2014-09-12

    The receiver frequency passband response is primarily determined by the band pass filter in the REU. The characteristics of the frequency passband ...Naval Research Laboratory Washington, DC 20375-5320 NRL/MR/7220--14-9558 Analysis of the WindSat Receiver Frequency Passbands September 12, 2014...Receiver Frequency Passbands Michael H. Bettenhausen and Peter W. Gaiser Naval Research Laboratory 4555 Overlook Avenue, SW Washington, DC 20375-5350

  10. Comparison of analytical eddy current models using principal components analysis

    Science.gov (United States)

    Contant, S.; Luloff, M.; Morelli, J.; Krause, T. W.

    2017-02-01

    Monitoring the gap between the pressure tube (PT) and the calandria tube (CT) in CANDU® fuel channels is essential, as contact between the two tubes can lead to delayed hydride cracking of the pressure tube. Multifrequency transmit-receive eddy current non-destructive evaluation is used to determine this gap, as this method has different depths of penetration and variable sensitivity to noise, unlike single frequency eddy current non-destructive evaluation. An Analytical model based on the Dodd and Deeds solutions, and a second model that accounts for normal and lossy self-inductances, and a non-coaxial pickup coil, are examined for representing the response of an eddy current transmit-receive probe when considering factors that affect the gap response, such as pressure tube wall thickness and pressure tube resistivity. The multifrequency model data was analyzed using principal components analysis (PCA), a statistical method used to reduce the data set into a data set of fewer variables. The results of the PCA of the analytical models were then compared to PCA performed on a previously obtained experimental data set. The models gave similar results under variable PT wall thickness conditions, but the non-coaxial coil model, which accounts for self-inductive losses, performed significantly better than the Dodd and Deeds model under variable resistivity conditions.

  11. CANSAR. Analytical irradiation for PCI analysis

    International Nuclear Information System (INIS)

    Bruet, M.; Lemaignan, C.

    1984-01-01

    The aim of ''CANSAR'' analytical irradiation is to evaluate the various mechanisms expected to be active during PCI failures (local concentration of fission products, fuel expansion, stress concentration induced by fuel fragment relocation, etc.). Two identical test pins, similar to classical PWR pins, but shorter, will be power-ramped in parallel. They will be filled with fuel pellets machined in various ways in order to simulate pellet fracture, relocation and preferential fission product migration path. One pin is highly instrumented with fission gas analysis, centre-line temperature and strain gauges on the cladding. The other can be unloaded between the pile cycles to perform other measurements such as diameter change, eddy currents, hot cell γ scanning. The gauges are necessary to obtain valuable information on cladding stresses. However, they induce significant modification of the thermal and mechanical behaviour of the cladding. Extensive finite element computation has been undertaken to estimate the temperature shift and the cladding reinforcement due to the gauges. Details of this work performed to design and implement the experiment will be presented. This included, in particular, high precision machining of UO 2 sectors to obtain ''precracked'' pellets and computation of the thermo-mechanical behaviour of the cladding with the gauges. (author)

  12. Analytical dosimetry for spontaneous tumor dogs receiving boron neutron capture therapy

    International Nuclear Information System (INIS)

    Wheeler, F.J.; Atkinson, C.A.; Gavin, P.R.

    1992-01-01

    The dog irradiation project of the Power Burst Facility/Boron Neutron Capture Therapy (PBF/BNCT) Program is administered by Washington State University (WSU) with analytical and physical dosimetry provided by the Idaho National Engineering Laboratory (INEL). One subtask of this project includes BNCT safety studies for dogs with spontaneously-occurring brain tumors. The boron compound (Na 2 B 12 H 11 SH or BSH) was administered and single irradiations performed using the epithermal-neutron beam at the Brookhaven Medical Research Reactor (BMRR). The main goal of the study was not to provide therapy, but to determine tumorcidal effect while administering a subtolerance dose to healthy tissue. Irradiation times were based on delivery of 19 Gy peak physical dose to the blood

  13. Sensor Network Information Analytical Methods: Analysis of Similarities and Differences

    Directory of Open Access Journals (Sweden)

    Chen Jian

    2014-04-01

    Full Text Available In the Sensor Network information engineering literature, few references focus on the definition and design of Sensor Network information analytical methods. Among those that do are Munson, et al. and the ISO standards on functional size analysis. To avoid inconsistent vocabulary and potentially incorrect interpretation of data, Sensor Network information analytical methods must be better designed, including definitions, analysis principles, analysis rules, and base units. This paper analyzes the similarities and differences across three different views of analytical methods, and uses a process proposed for the design of Sensor Network information analytical methods to analyze two examples of such methods selected from the literature.

  14. Analytical reliability analysis of soil-water characteristic curve

    Directory of Open Access Journals (Sweden)

    Johari A.

    2016-01-01

    Full Text Available The Soil Water Characteristic Curve (SWCC, also known as the soil water-retention curve, is an important part of any constitutive relationship for unsaturated soils. Deterministic assessment of SWCC has received considerable attention in the past few years. However the uncertainties of the parameters which affect SWCC dictate that the problem is of a probabilistic nature rather than being deterministic. In this research, a Gene Expression Programming (GEP-based SWCC model is employed to assess the reliability of SWCC. For this purpose, the Jointly Distributed Random Variables (JDRV method is used as an analytical method for reliability analysis. All input parameters of the model which are initial void ratio, initial water content, silt and clay contents are set to be stochastic and modelled using truncated normal probability density functions. The results are compared with those of the Monte Carlo (MC simulation. It is shown that the initial water content is the most effective parameter in SWCC.

  15. Workflow and cost analysis on MODULAR ANALYTICS.

    Science.gov (United States)

    Stolz, Herbert; Dossler, Bettina; Keller, Franz; Steigerwald, Udo

    2003-01-01

    Four stand-alone analyzers in a centralized laboratory were replaced by two modular analytical systems processing 45 methods of the general chemistry and specific protein segment. This consolidation led to a reduction of the daily workflow and operational costs. The cost saving with 1.3 million reported results per year was 53,000 Euro, which can be assessed as an important contribution to cost reduction in the health care system.

  16. Hydrocarbons in soil: analytical problems and interpretations in risk analysis

    International Nuclear Information System (INIS)

    Cambiaghi, M.; Cogliati, N.; Maspero, M.

    2009-01-01

    Risk analysis application to industrial sites contaminated by heavy hydrocarbons remains problematic. This is mainly due to a lack in analytical methods required to quantity hydrocarbons fractions needed to asses site quality, especially when aged pollution is involved. [it

  17. New analytical techniques for cuticle chemical analysis

    Energy Technology Data Exchange (ETDEWEB)

    Schulten, H.R. [Fachhochschule Fresenius, Dept. of Trace Analysis, Wiesbaden (Germany)

    1994-12-31

    1) The analytical methodology of pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS) and direct pyrolysis-mass spectrometry (Py-MS) using soft ionization techniques by high electric fields (FL) are briefly described. Recent advances of Py-GC/MS and Py-FIMS for the analyses of complex organic matter such as plant materials, humic substances, dissolved organic matter in water (DOM) and soil organic matter (SOM) in agricultural and forest soils are given to illustrate the potential and limitations of the applied methods. 2) Novel applications of Py-GC/MS and Py-MS in combination with conventional analytical data in an integrated, chemometric approach to investigate the dynamics of plant lipids are reported. This includes multivariate statistical investigations on maturation, senescence, humus genesis, and environmental damages in spruce ecosystems. 3) The focal point is the author`s integrated investigations on emission-induced changes of selected conifer plant constituents. Pattern recognition of Py-MS data of desiccated spruce needles provides a method for distinguishing needles damaged in different ways and determining the cause. Spruce needles were collected from both controls and trees treated with sulphur dioxide (acid rain), nitrogen dioxide, and ozone under controlled conditions. Py-MS and chemometric data evaluation are employed to characterize and classify leaves and their epicuticular waxes. Preliminary mass spectrometric evaluations of isolated cuticles of different plants such as spruce, ivy, holly, and philodendron, as well as ivy cuticles treated in vivo with air pollutants such as surfactants and pesticides are given. (orig.)

  18. New analytical techniques for cuticle chemical analysis

    International Nuclear Information System (INIS)

    Schulten, H.R.

    1994-01-01

    1) The analytical methodology of pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS) and direct pyrolysis-mass spectrometry (Py-MS) using soft ionization techniques by high electric fields (FL) are briefly described. Recent advances of Py-GC/MS and Py-FIMS for the analyses of complex organic matter such as plant materials, humic substances, dissolved organic matter in water (DOM) and soil organic matter (SOM) in agricultural and forest soils are given to illustrate the potential and limitations of the applied methods. 2) Novel applications of Py-GC/MS and Py-MS in combination with conventional analytical data in an integrated, chemometric approach to investigate the dynamics of plant lipids are reported. This includes multivariate statistical investigations on maturation, senescence, humus genesis, and environmental damages in spruce ecosystems. 3) The focal point is the author's integrated investigations on emission-induced changes of selected conifer plant constituents. Pattern recognition of Py-MS data of desiccated spruce needles provides a method for distinguishing needles damaged in different ways and determining the cause. Spruce needles were collected from both controls and trees treated with sulphur dioxide (acid rain), nitrogen dioxide, and ozone under controlled conditions. Py-MS and chemometric data evaluation are employed to characterize and classify leaves and their epicuticular waxes. Preliminary mass spectrometric evaluations of isolated cuticles of different plants such as spruce, ivy, holly, and philodendron, as well as ivy cuticles treated in vivo with air pollutants such as surfactants and pesticides are given. (orig.)

  19. Receiver function analysis using AlpArray stations in Hungary

    Science.gov (United States)

    Dániel, Kalmár; Bálint, Süle; István, Bondár

    2017-04-01

    The AlpArray temporary seismic network, together with the permanent stations of the Hungarian National Seismological Network provid an unprecedented density and resolution to study the Eastern Alps - Pannonian basin transition zone. Previous receiver functions studies .(Hetényi et al., 2007, 2015) in the region used a much smaller station density and shorter time period than the present paper. In the analysis we used data from 48 permanent and temporary AlpArray stations in Hungary and neighbouring countries. We present our methodology (P-wave receiver function analysis, H-K grid search and cross-correlation matrix methods), the pitfalls in processing, and finally our result, the detailed Moho map of the region.

  20. Summative Mass Analysis of Algal Biomass - Integration of Analytical Procedures: Laboratory Analytical Procedure (LAP)

    Energy Technology Data Exchange (ETDEWEB)

    Laurens, Lieve M. L.

    2016-01-13

    This procedure guides the integration of laboratory analytical procedures to measure algal biomass constituents in an unambiguous manner and ultimately achieve mass balance closure for algal biomass samples. Many of these methods build on years of research in algal biomass analysis.

  1. UV Lidar Receiver Analysis for Tropospheric Sensing of Ozone

    Science.gov (United States)

    Pliutau, Denis; DeYoung, Russell J.

    2013-01-01

    A simulation of a ground based Ultra-Violet Differential Absorption Lidar (UV-DIAL) receiver system was performed under realistic daytime conditions to understand how range and lidar performance can be improved for a given UV pulse laser energy. Calculations were also performed for an aerosol channel transmitting at 3 W. The lidar receiver simulation studies were optimized for the purpose of tropospheric ozone measurements. The transmitted lidar UV measurements were from 285 to 295 nm and the aerosol channel was 527-nm. The calculations are based on atmospheric transmission given by the HITRAN database and the Modern Era Retrospective Analysis for Research and Applications (MERRA) meteorological data. The aerosol attenuation is estimated using both the BACKSCAT 4.0 code as well as data collected during the CALIPSO mission. The lidar performance is estimated for both diffuseirradiance free cases corresponding to nighttime operation as well as the daytime diffuse scattered radiation component based on previously reported experimental data. This analysis presets calculations of the UV-DIAL receiver ozone and aerosol measurement range as a function of sky irradiance, filter bandwidth and laser transmitted UV and 527-nm energy

  2. Activation analysis in food analytics Pt. 2

    International Nuclear Information System (INIS)

    Szabo, A.; Bogancs, J.; Mihalyi, E.

    1979-01-01

    The composition of dried tomato products was examined by activation analysis. The following elements were determined: K, Na, Cl, Br, Mn, Au, Cu, Zn, Sb, As. The deviation of parallel measurements was < 2% in the case of Na, K, Cl, and < 10% in the case of Cu, Zn, Mn and Br. However, the deviation in cases of As, Sb and Au determinations exceeded 50%. The composition of a standard biological sample was also determined, and the results of activation analysis were in good agreement with literature data. (L.E.)

  3. Correlation analysis between ionospheric scintillation levels and receiver tracking performance

    Science.gov (United States)

    Sreeja, V.; Aquino, M.; Elmas, Z. G.; Forte, B.

    2012-06-01

    Rapid fluctuations in the amplitude and phase of a transionospheric radio signal caused by small scale plasma density irregularities in the ionosphere are known as scintillation. Scintillation can seriously impair a GNSS (Global Navigation Satellite Systems) receiver tracking performance, thus affecting the required levels of availability, accuracy and integrity, and consequently the reliability of modern day GNSS based applications. This paper presents an analysis of correlation between scintillation levels and tracking performance of a GNSS receiver for GPS L1C/A, L2C and GLONASS L1, L2 signals. The analyses make use of data recorded over Presidente Prudente (22.1°S, 51.4°W, dip latitude ˜12.3°S) in Brazil, a location close to the Equatorial Ionisation Anomaly (EIA) crest in Latin America. The study presents for the first time this type of correlation analysis for GPS L2C and GLONASS L1, L2 signals. The scintillation levels are defined by the amplitude scintillation index, S4 and the receiver tracking performance is evaluated by the phase tracking jitter. Both S4 and the phase tracking jitter are estimated from the post correlation In-Phase (I) and Quadra-Phase (Q) components logged by the receiver at a high rate. Results reveal that the dependence of the phase tracking jitter on the scintillation levels can be represented by a quadratic fit for the signals. The results presented in this paper are of importance to GNSS users, especially in view of the forthcoming high phase of solar cycle 24 (predicted for 2013).

  4. Second-Order Analytical Uncertainty Analysis in Life Cycle Assessment.

    Science.gov (United States)

    von Pfingsten, Sarah; Broll, David Oliver; von der Assen, Niklas; Bardow, André

    2017-11-21

    Life cycle assessment (LCA) results are inevitably subject to uncertainties. Since the complete elimination of uncertainties is impossible, LCA results should be complemented by an uncertainty analysis. However, the approaches currently used for uncertainty analysis have some shortcomings: statistical uncertainty analysis via Monte Carlo simulations are inherently uncertain due to their statistical nature and can become computationally inefficient for large systems; analytical approaches use a linear approximation to the uncertainty by a first-order Taylor series expansion and thus, they are only precise for small input uncertainties. In this article, we refine the analytical uncertainty analysis by a more precise, second-order Taylor series expansion. The presented approach considers uncertainties from process data, allocation, and characterization factors. We illustrate the refined approach for hydrogen production from methane-cracking. The production system contains a recycling loop leading to nonlinearities. By varying the strength of the loop, we analyze the precision of the first- and second-order analytical uncertainty approaches by comparing analytical variances to variances from statistical Monte Carlo simulations. For the case without loops, the second-order approach is practically exact. In all cases, the second-order Taylor series approach is more precise than the first-order approach, in particular for large uncertainties and for production systems with nonlinearities, for example, from loops. For analytical uncertainty analysis, we recommend using the second-order approach since it is more precise and still computationally cheap.

  5. Analytical analysis of sensitivity of optical waveguide sensor

    African Journals Online (AJOL)

    user

    In this article, we carried out analytical analysis of sensitivity and mode field of optical waveguide structure by use of effective index method. This structures as predicted have extended ..... analysis, Antennas, Optical & Photonic Waveguide. She has widely worked with Microcontrollers, uses artificial intelligence techniques .

  6. An overview on forensic analysis devoted to analytical chemists.

    Science.gov (United States)

    Castillo-Peinado, L S; Luque de Castro, M D

    2017-05-15

    The present article has as main aim to show analytical chemists interested in forensic analysis the world they will face if decision in favor of being a forensic analytical chemist is adopted. With this purpose, the most outstanding aspects of forensic analysis in dealing with sampling (involving both bodily and no bodily samples), sample preparation, and analytical equipment used in detection, identification and quantitation of key sample components are critically discussed. The role of the great omics in forensic analysis, and the growing role of the youngest of the great omics -metabolomics- are also discussed. The foreseeable role of integrative omics is also outlined. Copyright © 2017 Elsevier B.V. All rights reserved.

  7. THE ANALYSIS OF SEWAGE SYSTEM INFLUENCE ON RECEIVERS

    Directory of Open Access Journals (Sweden)

    Kamil Pluta

    2015-11-01

    Full Text Available Reducing waste water discharges to the receiver is now one of the most important activities to ensure the protection of surface waters. This is caused mainly by progressive urbanization and increasing impervious surfaces. Discharge of sewage with a large load of pollutants affect the receivers in a negative way. The quality of waste water varies and depends on many factors, but above all, it is closely linked with sewer system applied to the drainage catchment. The article presents a comparative analysis of the environmental impact of three basic sewer systems: combined, separate and semi-separate. The analysis was performed for a typical urban catchment, using the average concentration of the basic indicators of pollution, which total suspended solids, nitrogen and phosphorus, COD, BOD5, selected heavy metals are merked. The results concluded that each of these sewer systems characterized by varying environmental impacts depending on the indicator of pollution. The best of today available technical solutions seem to be semi-separate sewer system, using the storage tank with the control in real time (RTC for controlling the flow.

  8. Orthonormal polynomials in wavefront analysis: analytical solution.

    Science.gov (United States)

    Mahajan, Virendra N; Dai, Guang-ming

    2007-09-01

    Zernike circle polynomials are in widespread use for wavefront analysis because of their orthogonality over a circular pupil and their representation of balanced classical aberrations. In recent papers, we derived closed-form polynomials that are orthonormal over a hexagonal pupil, such as the hexagonal segments of a large mirror. We extend our work to elliptical, rectangular, and square pupils. Using the circle polynomials as the basis functions for their orthogonalization over such pupils, we derive closed-form polynomials that are orthonormal over them. These polynomials are unique in that they are not only orthogonal across such pupils, but also represent balanced classical aberrations, just as the Zernike circle polynomials are unique in these respects for circular pupils. The polynomials are given in terms of the circle polynomials as well as in polar and Cartesian coordinates. Relationships between the orthonormal coefficients and the corresponding Zernike coefficients for a given pupil are also obtained. The orthonormal polynomials for a one-dimensional slit pupil are obtained as a limiting case of a rectangular pupil.

  9. Design and simulation analysis of non-receiver aware and receiver ...

    African Journals Online (AJOL)

    We present multicast extensions to our recently proposed Location Prediction Based Routing (LPBR) protocol, referred to as NR-MLPBR and R-MLPBR, to simultaneously reduce the number of multicast tree discoveries and number of links per tree and/or the hop count per source-receiver path in mobile ad hoc networks ...

  10. FASP, an analytic resource appraisal program for petroleum play analysis

    Science.gov (United States)

    Crovelli, R.A.; Balay, R.H.

    1986-01-01

    An analytic probabilistic methodology for resource appraisal of undiscovered oil and gas resources in play analysis is presented in a FORTRAN program termed FASP. This play-analysis methodology is a geostochastic system for petroleum resource appraisal in explored as well as frontier areas. An established geologic model considers both the uncertainty of the presence of the assessed hydrocarbon and its amount if present. The program FASP produces resource estimates of crude oil, nonassociated gas, dissolved gas, and gas for a geologic play in terms of probability distributions. The analytic method is based upon conditional probability theory and many laws of expectation and variance. ?? 1986.

  11. Risk analysis of analytical validations by probabilistic modification of FMEA

    DEFF Research Database (Denmark)

    Barends, D.M.; Oldenhof, M.T.; Vredenbregt, M.J.

    2012-01-01

    Risk analysis is a valuable addition to validation of an analytical chemistry process, enabling not only detecting technical risks, but also risks related to human failures. Failure Mode and Effect Analysis (FMEA) can be applied, using a categorical risk scoring of the occurrence, detection...... of severity. In an example, the results of traditional FMEA of a Near Infrared (NIR) analytical procedure used for the screening of suspected counterfeited tablets are re-interpretated by this probabilistic modification of FMEA. Using this probabilistic modification of FMEA, the frequency of occurrence...... of undetected failure mode(s) can be estimated quantitatively, for each individual failure mode, for a set of failure modes, and the full analytical procedure....

  12. Nuclear activation analysis work at Analytical Chemistry Division: an overview

    International Nuclear Information System (INIS)

    Verma, R.; Swain, K.K.; Remya Devi, P.S.; Dalvi, Aditi A.; Ajith, Nicy; Ghosh, M.; Chowdhury, D.P.; Datta, J.; Dasgupta, S.

    2016-04-01

    Nuclear activation analysis using neutron and charged particles is used routinely for analysis and research at Analytical Chemistry Division (ACD), Bhabha Atomic Research Centre (BARC). Neutron activation analysis at ACD, BARC, Mumbai, India has been pursued since late fifties using Apsara, CIRUS, Dhruva and Critical facility Research reactors, 239 Pu-Be neutron source and neutron generator. Instrumental, Radiochemical, Chemical and Derivative neutron activation analysis approaches are adopted depending on the analyte and the matrix. Large sample neutron activation analysis as well as k 0 -based internal monostandard neutron activation analysis is also used. Charged particle activation analysis at ACD, Variable Energy Cyclotron Centre (VECC), Kolkata started in late eighties and is being used for industrial applications and research. Proton, alpha, deuteron and heavy ion beams from 224 cm room temperature Variable Energy Cyclotron are used for determination of trace elements, measurement of excitation function, thin layer activation and preparation of endohedral fullerenes encapsulated with radioactive isotopes. Analytical Chemistry Division regularly participates in Inter and Intra laboratory comparison exercises conducted by various organizations including International Atomic Energy Agency (IAEA) and the results invariably include values obtained by neutron activation analysis. (author)

  13. Analytical analysis of sensitivity of optical waveguide sensor | Verma ...

    African Journals Online (AJOL)

    In this article, we carried out analytical analysis of sensitivity and mode field of optical waveguide structure by use of effective index method. This structures as predicted have extended mode which could interact with the surrounding analyses in a much better way than the commonly used EWS.

  14. Analysis of the Extracts of Isatis tinctoria by New Analytical ...

    African Journals Online (AJOL)

    The methods of extraction, separation and analysis of alkaloids and indole glucosinolates (GLs) of Isatis tinctoria were reviewed. Different analytical approaches such as High-pressure Liquid Chromatography (HPLC), Liquid Chromatography with Electrospray Ionization Mass Spectrometry (LC/ESI/MS), Electrospray ...

  15. Flow Injection Analysis: A Revolution in Modern Analytical Chemistry

    DEFF Research Database (Denmark)

    Hansen, Elo Harald

    1996-01-01

    A review is made of the fundamentals of Flow Injection Analysis (FIA), and the versatility and applicability of this analytical concept is demonstrated by a series of examples, comprizing the use of different types of FIA-manifolds and various detection devices (optical and electrochemical...

  16. Applicability of analytical instrument in trace evidence analysis

    International Nuclear Information System (INIS)

    Sharma, Mukesh; Jha, Shailendra

    2014-01-01

    In the present paper, we explain the importance of the analytical instrument used in the field of forensic science for the analysis of the trace evidences collected from the scene of occurrence. The forensic scientist has to rely upon these instrumental analyses of trace amounts of materials like drugs, toxicological specimens, GSR, fibres, glass, paints, soil etc. Through this paper, reviews on these techniques which are extensively used in forensic sciences are reported. Our report summaries on the basis of analytical problem facing for a forensic expert and techniques employed to tackle them like XRD/XRF, inductively coupled plasma (ICP) techniques, Raman spectroscopy and microscopy (optical, GRIM, electron microscopy, TEM). (author)

  17. The Cycle of Warfare - Analysis of an Analytical Model

    DEFF Research Database (Denmark)

    Jensen, Mikkel Storm

    2016-01-01

    The abstract has the title: “The Cycle of Warfare - Analysis of an Analytical Model” The Cycle of Warfare is an analytical model designed to illustrate the coherence between the organization, doctrine and technology of a military entity and the influence of the surrounding society as expressed...... both retrospectively and predictively. As a tool for historians the model can help to identify decisive factors in developments and outcomes. As a tool for intelligence analysts, it can be used predictively to identify likely possible outcomes or unknown elements in analysed entities....

  18. Analytic uncertainty and sensitivity analysis of models with input correlations

    Science.gov (United States)

    Zhu, Yueying; Wang, Qiuping A.; Li, Wei; Cai, Xu

    2018-03-01

    Probabilistic uncertainty analysis is a common means of evaluating mathematical models. In mathematical modeling, the uncertainty in input variables is specified through distribution laws. Its contribution to the uncertainty in model response is usually analyzed by assuming that input variables are independent of each other. However, correlated parameters are often happened in practical applications. In the present paper, an analytic method is built for the uncertainty and sensitivity analysis of models in the presence of input correlations. With the method, it is straightforward to identify the importance of the independence and correlations of input variables in determining the model response. This allows one to decide whether or not the input correlations should be considered in practice. Numerical examples suggest the effectiveness and validation of our analytic method in the analysis of general models. A practical application of the method is also proposed to the uncertainty and sensitivity analysis of a deterministic HIV model.

  19. Analytical techniques for wine analysis: An African perspective; a review

    International Nuclear Information System (INIS)

    Villiers, André de; Alberts, Phillipus; Tredoux, Andreas G.J.; Nieuwoudt, Hélène H.

    2012-01-01

    Highlights: ► Analytical techniques developed for grape and wine analysis in Africa are reviewed. ► The utility of infrared spectroscopic methods is demonstrated. ► An overview of separation of wine constituents by GC, HPLC, CE is presented. ► Novel LC and GC sample preparation methods for LC and GC are presented. ► Emerging methods for grape and wine analysis in Africa are discussed. - Abstract: Analytical chemistry is playing an ever-increasingly important role in the global wine industry. Chemical analysis of wine is essential in ensuring product safety and conformity to regulatory laws governing the international market, as well as understanding the fundamental aspects of grape and wine production to improve manufacturing processes. Within this field, advanced instrumental analysis methods have been exploited more extensively in recent years. Important advances in instrumental analytical techniques have also found application in the wine industry. This review aims to highlight the most important developments in the field of instrumental wine and grape analysis in the African context. The focus of this overview is specifically on the application of advanced instrumental techniques, including spectroscopic and chromatographic methods. Recent developments in wine and grape analysis and their application in the African context are highlighted, and future trends are discussed in terms of their potential contribution to the industry.

  20. Analytical techniques for wine analysis: An African perspective; a review

    Energy Technology Data Exchange (ETDEWEB)

    Villiers, Andre de, E-mail: ajdevill@sun.ac.za [Department of Chemistry and Polymer Science, Stellenbosch University, Private Bag X1, Matieland 7602, Stellenbosch (South Africa); Alberts, Phillipus [Department of Chemistry and Polymer Science, Stellenbosch University, Private Bag X1, Matieland 7602, Stellenbosch (South Africa); Tredoux, Andreas G.J.; Nieuwoudt, Helene H. [Institute for Wine Biotechnology, Department of Viticulture and Oenology, Stellenbosch University, Private Bag X1, Matieland 7602, Stellenbosch (South Africa)

    2012-06-12

    Highlights: Black-Right-Pointing-Pointer Analytical techniques developed for grape and wine analysis in Africa are reviewed. Black-Right-Pointing-Pointer The utility of infrared spectroscopic methods is demonstrated. Black-Right-Pointing-Pointer An overview of separation of wine constituents by GC, HPLC, CE is presented. Black-Right-Pointing-Pointer Novel LC and GC sample preparation methods for LC and GC are presented. Black-Right-Pointing-Pointer Emerging methods for grape and wine analysis in Africa are discussed. - Abstract: Analytical chemistry is playing an ever-increasingly important role in the global wine industry. Chemical analysis of wine is essential in ensuring product safety and conformity to regulatory laws governing the international market, as well as understanding the fundamental aspects of grape and wine production to improve manufacturing processes. Within this field, advanced instrumental analysis methods have been exploited more extensively in recent years. Important advances in instrumental analytical techniques have also found application in the wine industry. This review aims to highlight the most important developments in the field of instrumental wine and grape analysis in the African context. The focus of this overview is specifically on the application of advanced instrumental techniques, including spectroscopic and chromatographic methods. Recent developments in wine and grape analysis and their application in the African context are highlighted, and future trends are discussed in terms of their potential contribution to the industry.

  1. An Analysis of Earth Science Data Analytics Use Cases

    Science.gov (United States)

    Shie, Chung-Lin; Kempler, Steve

    2014-01-01

    The increase in the number and volume, and sources, of globally available Earth science data measurements and datasets have afforded Earth scientists and applications researchers unprecedented opportunities to study our Earth in ever more sophisticated ways. In fact, the NASA Earth Observing System Data Information System (EOSDIS) archives have doubled from 2007 to 2014, to 9.1 PB (Ramapriyan, 2009; and https:earthdata.nasa.govaboutsystem-- performance). In addition, other US agency, international programs, field experiments, ground stations, and citizen scientists provide a plethora of additional sources for studying Earth. Co--analyzing huge amounts of heterogeneous data to glean out unobvious information is a daunting task. Earth science data analytics (ESDA) is the process of examining large amounts of data of a variety of types to uncover hidden patterns, unknown correlations and other useful information. It can include Data Preparation, Data Reduction, and Data Analysis. Through work associated with the Earth Science Information Partners (ESIP) Federation, a collection of Earth science data analytics use cases have been collected and analyzed for the purpose of extracting the types of Earth science data analytics employed, and requirements for data analytics tools and techniques yet to be implemented, based on use case needs. ESIP generated use case template, ESDA use cases, use case types, and preliminary use case analysis (this is a work in progress) will be presented.

  2. Receiver operating characteristic analysis improves diagnosis by radionuclide ventriculography

    International Nuclear Information System (INIS)

    Dickinson, C.Z.; Forman, M.B.; Vaugh, W.K.; Sandler, M.P.; Kronenberg, M.W.

    1985-01-01

    Receiver operating characteristic analysis (ROC) evaluates continuous variables to define diagnostic criteria for the optimal sensitivity (SENS) and specificity (SPEC) of a test. The authors studied exercise-induced chest pain (CP), ST-changes on electrocardiography (ECG) and rest-exercise gated radionuclide ventriculography (RVG) using ROC to clarify the optimal criteria for detecting myocardial ischemia due to coronary artherosclerosis (CAD). The data of 95 consecutive patients studied with coronary angiography, rest-exercise RVG and ECG were reviewed. 77 patients had ''significant'' CAD (≥50% lesions). Exercise-induced CP, ECG abnormalities (ST-T shifts) and RVG abnormalities (change in ejection fraction, 2-view regional wall motion change and relative end-systolic volume) were evaluated to define optimal SENS/SPEC of each and for the combined data. ROC curves were constructed by multiple logistic regression (MLR). By MLR, RVG alone was superior to ECG and CP. The combination of all three produced the best ROC curve for the entire group and for clinical subsets based on the number of diseased vessels and the presence or absence of prior myocardial infarction. When CP, ECG and RVG were combined, the optimal SENS/SPEC for detection of single vessel disease was 88/86. The SENS/SPEC for 3 vessel disease was 93/95. Thus, the application of RVG for the diagnosis of myocardial ischemia is improved with the inclusion of ECG and CP data by the use of a multiple logistic regression model. ROC analysis allows clinical application of multiple data for diagnosing CAD at desired SENS/SPEC rather than by arbitrary single-standard criteria

  3. Evaluation and Error Analysis for a Solar Thermal Receiver

    International Nuclear Information System (INIS)

    Pfander, M.

    2001-01-01

    In the following study a complete balance over the REFOS receiver module, mounted on the tower power plant CESA-1 at the Plataforma Solar de Almeria (PSA), is carried out. Additionally an error inspection of the various measurement techniques used in the REFOS project is made. Especially the flux measurement system Pro hermes that is used to determine the total entry power of the receiver module and known as a major error source is analysed in detail. Simulations and experiments on the particular instruments are used to determine and quantify possible error sources. After discovering the origin of the errors they are reduced and included in the error calculation. The ultimate result is presented as an overall efficiency of the receiver module in dependence on the flux density at the receiver modules entry plane and the receiver operating temperature. (Author) 26 refs

  4. Evaluation and Error Analysis for a Solar thermal Receiver

    Energy Technology Data Exchange (ETDEWEB)

    Pfander, M.

    2001-07-01

    In the following study a complete balance over the REFOS receiver module, mounted on the tower power plant CESA-1 at the Plataforma Solar de Almeria (PSA), is carried out. Additionally an error inspection of the various measurement techniques used in the REFOS project is made. Especially the flux measurement system Prohermes that is used to determine the total entry power of the receiver module and known as a major error source is analysed in detail. Simulations and experiments on the particular instruments are used to determine and quantify possible error sources. After discovering the origin of the errors they are reduced and included in the error calculation. the ultimate result is presented as an overall efficiency of the receiver module in dependence on the flux density at the receiver module's entry plane and the receiver operating temperature. (Author) 26 refs.

  5. THE ANALYSIS OF SEWAGE SYSTEM INFLUENCE ON RECEIVERS

    OpenAIRE

    Kamil Pluta

    2015-01-01

    Reducing waste water discharges to the receiver is now one of the most important activities to ensure the protection of surface waters. This is caused mainly by progressive urbanization and increasing impervious surfaces. Discharge of sewage with a large load of pollutants affect the receivers in a negative way. The quality of waste water varies and depends on many factors, but above all, it is closely linked with sewer system applied to the drainage catchment. The article presents a comparat...

  6. Waste Receiving and Processing (WRAP) Weight Scale Analysis Results

    International Nuclear Information System (INIS)

    JOHNSON, M.D.

    2000-01-01

    Fairbanks Weight Scales are used at the Waste Receiving and Processing (WRAP) facility to determine the weight of waste drums as they are received, processed, and shipped. Due to recent problems, discovered during calibration, the WRAP Engineering Department has completed this document which outlines both the investigation of the infeed conveyor scale failure in September of 1999 and recommendations for calibration procedure modifications designed to correct deficiencies in the current procedures

  7. Performance analysis of underlay cognitive multihop regenerative relaying systems with multiple primary receivers

    KAUST Repository

    Hyadi, Amal

    2013-12-01

    Multihop relaying is an efficient strategy to improve the connectivity and extend the coverage area of secondary networks in underlay cognitive systems. In this work, we provide a comprehensive performance study of cognitive multihop regenerative relaying systems in an underlay spectrum sharing scenario with the presence of multiple primary receivers. Both interference power and peak power constraints are taken into account. In our analysis, all the links are subject to independent, non-identically distributed Nakagami-m fading. We derive closed-form expressions for the outage probability, high-order amount of fading, bit error rate, symbol error rate, and ergodic capacity. Different scenarios are presented to illustrate the obtained results and Monte Carlo simulations confirm the accuracy of our analytical derivations. © 2013 IEEE.

  8. Optimization of Turbine Engine Cycle Analysis with Analytic Derivatives

    Science.gov (United States)

    Hearn, Tristan; Hendricks, Eric; Chin, Jeffrey; Gray, Justin; Moore, Kenneth T.

    2016-01-01

    A new engine cycle analysis tool, called Pycycle, was recently built using the OpenMDAO framework. This tool uses equilibrium chemistry based thermodynamics, and provides analytic derivatives. This allows for stable and efficient use of gradient-based optimization and sensitivity analysis methods on engine cycle models, without requiring the use of finite difference derivative approximation methods. To demonstrate this, a gradient-based design optimization was performed on a multi-point turbofan engine model. Results demonstrate very favorable performance compared to an optimization of an identical model using finite-difference approximated derivatives.

  9. Search Analytics: Automated Learning, Analysis, and Search with Open Source

    Science.gov (United States)

    Hundman, K.; Mattmann, C. A.; Hyon, J.; Ramirez, P.

    2016-12-01

    The sheer volume of unstructured scientific data makes comprehensive human analysis impossible, resulting in missed opportunities to identify relationships, trends, gaps, and outliers. As the open source community continues to grow, tools like Apache Tika, Apache Solr, Stanford's DeepDive, and Data-Driven Documents (D3) can help address this challenge. With a focus on journal publications and conference abstracts often in the form of PDF and Microsoft Office documents, we've initiated an exploratory NASA Advanced Concepts project aiming to use the aforementioned open source text analytics tools to build a data-driven justification for the HyspIRI Decadal Survey mission. We call this capability Search Analytics, and it fuses and augments these open source tools to enable the automatic discovery and extraction of salient information. In the case of HyspIRI, a hyperspectral infrared imager mission, key findings resulted from the extractions and visualizations of relationships from thousands of unstructured scientific documents. The relationships include links between satellites (e.g. Landsat 8), domain-specific measurements (e.g. spectral coverage) and subjects (e.g. invasive species). Using the above open source tools, Search Analytics mined and characterized a corpus of information that would be infeasible for a human to process. More broadly, Search Analytics offers insights into various scientific and commercial applications enabled through missions and instrumentation with specific technical capabilities. For example, the following phrases were extracted in close proximity within a publication: "In this study, hyperspectral images…with high spatial resolution (1 m) were analyzed to detect cutleaf teasel in two areas. …Classification of cutleaf teasel reached a users accuracy of 82 to 84%." Without reading a single paper we can use Search Analytics to automatically identify that a 1 m spatial resolution provides a cutleaf teasel detection users accuracy of 82

  10. Noodle based analytical devices for cost effective green chemical analysis.

    Science.gov (United States)

    Kiwfo, Kanokwan; Wongwilai, Wasin; Paengnakorn, Pathinan; Boonmapa, Sasithorn; Sateanchok, Suphasinee; Grudpan, Kate

    2018-05-01

    Noodle based analytical devices are proposed for cost effective green chemical analysis. Two noodle based analytical platforms have been examined. Conditions for flow with laminar behaviors could be established. Detection may be via a webcam camera or a flatbed scanner. Acid-base reactions were chosen as a model study. The assays of acetic acid and sodium hydroxide were investigated. Apart from bromothymol blue, simple aqueous extract of butterfly pea flower was used as a natural reagent. Another model was the assay of copper (Cu 2+ ) which was based on the redox reaction of copper (Cu 2+ ) with iodide to produce tri-iodide forming brown/black product with starch which already exists in the noodle platform. Demonstration to apply the noodle platforms for real samples was made. Copyright © 2017 Elsevier B.V. All rights reserved.

  11. Central receiver power plant: an environmental, ecological, and socioeconomic analysis

    Energy Technology Data Exchange (ETDEWEB)

    Davison, M.; Grether, D.

    1977-06-01

    The technical details of the central receiver design are reviewed. Socio-economic questions are considered including: market penetration, air industrial sector model, demands on industry, employment, effluents associated with manufacture of components, strains due to intensive construction, water requirements, and land requirements. The ecological effects in the vicinity of the central receiver plant site are dealt with, with emphasis on effects on land surface, mammals, and reptiles and amphibians. Climatological considerations are reviewed including: desert types, effects of surface albedo modification, effects of aerosols, effects on evaporation rates, the heliostat canopy, effects on turbulent transfer rates, effects on the wind profile, a model of convection about a central receiver plant, and a global scenario. Drawings of heliostat and plant design are included in appendices. (MHR)

  12. Macro elemental analysis of food samples by nuclear analytical technique

    Science.gov (United States)

    Syahfitri, W. Y. N.; Kurniawati, S.; Adventini, N.; Damastuti, E.; Lestiani, D. D.

    2017-06-01

    Energy-dispersive X-ray fluorescence (EDXRF) spectrometry is a non-destructive, rapid, multi elemental, accurate, and environment friendly analysis compared with other detection methods. Thus, EDXRF spectrometry is applicable for food inspection. The macro elements calcium and potassium constitute important nutrients required by the human body for optimal physiological functions. Therefore, the determination of Ca and K content in various foods needs to be done. The aim of this work is to demonstrate the applicability of EDXRF for food analysis. The analytical performance of non-destructive EDXRF was compared with other analytical techniques; neutron activation analysis and atomic absorption spectrometry. Comparison of methods performed as cross checking results of the analysis and to overcome the limitations of the three methods. Analysis results showed that Ca found in food using EDXRF and AAS were not significantly different with p-value 0.9687, whereas p-value of K between EDXRF and NAA is 0.6575. The correlation between those results was also examined. The Pearson correlations for Ca and K were 0.9871 and 0.9558, respectively. Method validation using SRM NIST 1548a Typical Diet was also applied. The results showed good agreement between methods; therefore EDXRF method can be used as an alternative method for the determination of Ca and K in food samples.

  13. Enhancing Safeguards through Information Analysis: Business Analytics Tools

    International Nuclear Information System (INIS)

    Vincent, J.; Midwinter, J.

    2015-01-01

    For the past 25 years the IBM i2 Intelligence Analysis product portfolio has assisted over 4,500 organizations across law enforcement, defense, government agencies, and commercial private sector businesses to maximize the value of the mass of information to discover and disseminate actionable intelligence that can help identify, investigate, predict, prevent, and disrupt criminal, terrorist, and fraudulent acts; safeguarding communities, organizations, infrastructures, and investments. The collaborative Intelligence Analysis environment delivered by i2 is specifically designed to be: · scalable: supporting business needs as well as operational and end user environments · modular: an architecture which can deliver maximum operational flexibility with ability to add complimentary analytics · interoperable: integrating with existing environments and eases information sharing across partner agencies · extendable: providing an open source developer essential toolkit, examples, and documentation for custom requirements i2 Intelligence Analysis brings clarity to complex investigations and operations by delivering industry leading multidimensional analytics that can be run on-demand across disparate data sets or across a single centralized analysis environment. The sole aim is to detect connections, patterns, and relationships hidden within high-volume, all-source data, and to create and disseminate intelligence products in near real time for faster informed decision making. (author)

  14. Two dimensional analysis of a high temperature gaseous radiation receiver

    Science.gov (United States)

    Mcfall, K. A.; Mattick, A. T.

    1992-01-01

    The characteristics of the Flowing Gas Radiation Receiver (FGRR), a device that absorbs solar radiation volumetrically in a gas to produce high temperatures for space propulsion and power applications, are analyzed using a two-dimensional axisymmetric numerical model of the flow and radiation fields within a diffusely reflecting channel. The results show that an FGRR system is capable of generating temperatures in excess of 3000 K with collection efficiencies of approximately 75 percent for a channel with a reflectivity of 0.9. For a collinear radiation source, outflow temperatures of 3193 and 3092 K were achieved for axial and radial flow inputs, respectively, with receiver efficiencies of 0.82 and 0.76.

  15. Analysis of received AIS data from a LEO Cubesat

    DEFF Research Database (Denmark)

    Larsen, Jesper Abildgaard; Mortensen, Hans Peter; Tausen, Mathias

    2014-01-01

    using their AIS broadcast signals as an indication of position by means of a simple dipole antenna. The SDR based receiver used on board the satellite is using a single chip front-end solution, which downconverts the AIS signal located around 162 MHz to an intermediate frequency at 200 kHz. This I....../Q signal is sampled with a 750 kSPS A/D converter and further processed by an Analog De- vices DSP. The algorithm first analyses the stream to identify possible AIS transmissions on the two different AIS channels. If likely transmissions are identified, the center frequency of the transmission is estimated...... of the satellite was to perform a feasibility study about the possibility of detecting AIS signals from a 1U cubesat in LEO. However, soon after launch it was found, that the AIS receiver performed very well and an improved algorithm which samples and decodes real-time was developed and uploaded to the satellite...

  16. The performance analysis of linux networking - packet receiving

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Wenji; Crawford, Matt; Bowden, Mark; /Fermilab

    2006-11-01

    The computing models for High-Energy Physics experiments are becoming ever more globally distributed and grid-based, both for technical reasons (e.g., to place computational and data resources near each other and the demand) and for strategic reasons (e.g., to leverage equipment investments). To support such computing models, the network and end systems, computing and storage, face unprecedented challenges. One of the biggest challenges is to transfer scientific data sets--now in the multi-petabyte (10{sup 15} bytes) range and expected to grow to exabytes within a decade--reliably and efficiently among facilities and computation centers scattered around the world. Both the network and end systems should be able to provide the capabilities to support high bandwidth, sustained, end-to-end data transmission. Recent trends in technology are showing that although the raw transmission speeds used in networks are increasing rapidly, the rate of advancement of microprocessor technology has slowed down. Therefore, network protocol-processing overheads have risen sharply in comparison with the time spent in packet transmission, resulting in degraded throughput for networked applications. More and more, it is the network end system, instead of the network, that is responsible for degraded performance of network applications. In this paper, the Linux system's packet receive process is studied from NIC to application. We develop a mathematical model to characterize the Linux packet receiving process. Key factors that affect Linux systems network performance are analyzed.

  17. Structural Analysis of Composite Laminates using Analytical and Numerical Techniques

    Directory of Open Access Journals (Sweden)

    Sanghi Divya

    2016-01-01

    Full Text Available A laminated composite material consists of different layers of matrix and fibres. Its properties can vary a lot with each layer’s or ply’s orientation, material property and the number of layers itself. The present paper focuses on a novel approach of incorporating an analytical method to arrive at a preliminary ply layup order of a composite laminate, which acts as a feeder data for the further detailed analysis done on FEA tools. The equations used in our MATLAB are based on analytical study code and supply results that are remarkably close to the final optimized layup found through extensive FEA analysis with a high probabilistic degree. This reduces significant computing time and saves considerable FEA processing to obtain efficient results quickly. The result output by our method also provides the user with the conditions that predicts the successive failure sequence of the composite plies, a result option which is not even available in popular FEM tools. The predicted results are further verified by testing the laminates in the laboratory and the results are found in good agreement.

  18. Analysis of received AIS data from a LEO Cubesat

    DEFF Research Database (Denmark)

    Larsen, Jesper Abildgaard; Mortensen, Hans Peter; Tausen, Mathias

    2014-01-01

    using their AIS broadcast signals as an indication of position by means of a simple dipole antenna. The SDR based receiver used on board the satellite is using a single chip front-end solution, which downconverts the AIS signal located around 162 MHz to an intermediate frequency at 200 kHz. This I...... in order to compensate for the Doppler shift due to the large speed difference between the satellite and the ships. After this a noncoherent demodulation takes place using the estimated center frequency. The initial SW in the SDR was implemented as a sample and process algorithm, since the primary mission...... to the SDR algorithms have been identified after the launch of the satellite, and these improved algorithms have been uploaded to the satellite. Although able to detect more than 10k packets/hour it is also found that the large field of view and high number of ships in heavily congested areas yields many...

  19. Receiver Operating Characteristic Analysis for Detecting Explosives-related Threats

    Energy Technology Data Exchange (ETDEWEB)

    Oxley, Mark E; Venzin, Alexander M

    2012-11-14

    The Department of Homeland Security (DHS) and the Transportation Security Administration (TSA) are interested in developing a standardized testing procedure for determining the performance of candidate detection systems. This document outlines a potential method for judging detection system performance as well as determining if combining the information from a legacy system with a new system can signicantly improve performance. In this document, performance corresponds to the Neyman-Pearson criterion applied to the Receiver Operating Characteristic (ROC) curves of the detection systems in question. A simulation was developed to investigate how the amount of data provided by the vendor in the form of the ROC curve eects the performance of the combined detection system. Furthermore, the simulation also takes into account the potential eects of correlation and how this information can also impact the performance of the combined system.

  20. Which diabetic patients should receive podiatry care? An objective analysis.

    Science.gov (United States)

    McGill, M; Molyneaux, L; Yue, D K

    2005-08-01

    Diabetes is the leading cause of lower limb amputation in Australia. However, due to limited resources, it is not feasible for everyone with diabetes to access podiatry care, and some objective guidelines of who should receive podiatry is required. A total of 250 patients with neuropathy (Biothesiometer; Biomedical Instruments, Newbury, Ohio, USA) ( > 30, age podiatry care (mean of estimates from 10 reports), the NNT to prevent one foot ulcer per year was: no neuropathy (vibration perception threshold (VPT) 30) alone, NNT = 45; +cannot feel monofilament, NNT = 18; +previous ulcer/amputation, NNT = 7. Provision of podiatry care to diabetic patients should not be only economically based, but should also be directed to those with reduced sensation, especially where there is a previous history of ulceration or amputation.

  1. Central Andean crustal structure from receiver function analysis

    Science.gov (United States)

    Ryan, Jamie; Beck, Susan; Zandt, George; Wagner, Lara; Minaya, Estela; Tavera, Hernado

    2016-07-01

    The Central Andean Plateau (15°-27°S) is a high plateau in excess of 3 km elevation, associated with thickened crust along the western edge of the South America plate, in the convergent margin between the subducting Nazca plate and the Brazilian craton. We have calculated receiver functions using seismic data from a recent portable deployment of broadband seismometers in the Bolivian orocline (12°-21°S) region and combined them with waveforms from 38 other stations in the region to investigate crustal thickness and crust and mantle structures. Results from the receiver functions provide a more detailed map of crustal thickness than previously existed, and highlight mid-crustal features that match well with prior studies. The active volcanic arc and Altiplano have thick crust with Moho depths increasing from the central Altiplano (65 km) to the northern Altiplano (75 km). The Eastern Cordillera shows large along strike variations in crustal thickness. Along a densely sampled SW-NE profile through the Bolivian orocline there is a small region of thin crust beneath the high peaks of the Cordillera Real where the average elevations are near 4 km, and the Moho depth varies from 55 to 60 km, implying the crust is undercompensated by 5 km. In comparison, a broader region of high elevations in the Eastern Cordillera to the southeast near 20°S has a deeper Moho at 65-70 km and appears close to isostatic equilibrium at the Moho. Assuming the modern-day pattern of high precipitation on the flanks of the Andean plateau has existed since the late Miocene, we suggest that climate induced exhumation can explain some of the variations in present day crustal structure across the Bolivian orocline. We also suggest that south of the orocline at 20°S, the thicker and isostatically compensated crust is due to the absence of erosional exhumation and the occurrence of lithospheric delamination.

  2. Learning Geospatial Analysis Skills with Consumer-Grade GPS Receivers and Low Cost Spatial Analysis Software

    Science.gov (United States)

    Linehan, Peter E.

    2006-01-01

    Spatial analysis technologies are increasingly important tools for all aspects of forest resource management. Field work previously accomplished with map, compass, and engineers' scale is now being augmented, or superseded, by the use of GPS and GIS. Professional-grade GPS receivers and commercial GIS software are preferred for their accuracy and…

  3. An Analytical Approach for Performance Enhancement of FSO Communication System Using Array of Receivers in Adverse Weather Conditions

    Science.gov (United States)

    Nagpal, Shaina; Gupta, Amit

    2017-08-01

    Free Space Optics (FSO) link exploits the tremendous network capacity and is capable of offering wireless communications similar to communications through optical fibres. However, FSO link is extremely weather dependent and the major effect on FSO links is due to adverse weather conditions like fog and snow. In this paper, an FSO link is designed using an array of receivers. The disparity of the link for very high attenuation conditions due to fog and snow is analysed using aperture averaging technique. Further effect of aperture averaging technique is investigated by comparing the systems using aperture averaging technique with systems not using aperture averaging technique. The performance of proposed model of FSO link has been evaluated in terms of Q factor, bit error rate (BER) and eye diagram.

  4. SEURAT: Visual analytics for the integrated analysis of microarray data

    Directory of Open Access Journals (Sweden)

    Bullinger Lars

    2010-06-01

    Full Text Available Abstract Background In translational cancer research, gene expression data is collected together with clinical data and genomic data arising from other chip based high throughput technologies. Software tools for the joint analysis of such high dimensional data sets together with clinical data are required. Results We have developed an open source software tool which provides interactive visualization capability for the integrated analysis of high-dimensional gene expression data together with associated clinical data, array CGH data and SNP array data. The different data types are organized by a comprehensive data manager. Interactive tools are provided for all graphics: heatmaps, dendrograms, barcharts, histograms, eventcharts and a chromosome browser, which displays genetic variations along the genome. All graphics are dynamic and fully linked so that any object selected in a graphic will be highlighted in all other graphics. For exploratory data analysis the software provides unsupervised data analytics like clustering, seriation algorithms and biclustering algorithms. Conclusions The SEURAT software meets the growing needs of researchers to perform joint analysis of gene expression, genomical and clinical data.

  5. SEURAT: visual analytics for the integrated analysis of microarray data.

    Science.gov (United States)

    Gribov, Alexander; Sill, Martin; Lück, Sonja; Rücker, Frank; Döhner, Konstanze; Bullinger, Lars; Benner, Axel; Unwin, Antony

    2010-06-03

    In translational cancer research, gene expression data is collected together with clinical data and genomic data arising from other chip based high throughput technologies. Software tools for the joint analysis of such high dimensional data sets together with clinical data are required. We have developed an open source software tool which provides interactive visualization capability for the integrated analysis of high-dimensional gene expression data together with associated clinical data, array CGH data and SNP array data. The different data types are organized by a comprehensive data manager. Interactive tools are provided for all graphics: heatmaps, dendrograms, barcharts, histograms, eventcharts and a chromosome browser, which displays genetic variations along the genome. All graphics are dynamic and fully linked so that any object selected in a graphic will be highlighted in all other graphics. For exploratory data analysis the software provides unsupervised data analytics like clustering, seriation algorithms and biclustering algorithms. The SEURAT software meets the growing needs of researchers to perform joint analysis of gene expression, genomical and clinical data.

  6. A Visual Analytics Approach for Correlation, Classification, and Regression Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Steed, Chad A [ORNL; SwanII, J. Edward [Mississippi State University (MSU); Fitzpatrick, Patrick J. [Mississippi State University (MSU); Jankun-Kelly, T.J. [Mississippi State University (MSU)

    2012-02-01

    New approaches that combine the strengths of humans and machines are necessary to equip analysts with the proper tools for exploring today's increasing complex, multivariate data sets. In this paper, a novel visual data mining framework, called the Multidimensional Data eXplorer (MDX), is described that addresses the challenges of today's data by combining automated statistical analytics with a highly interactive parallel coordinates based canvas. In addition to several intuitive interaction capabilities, this framework offers a rich set of graphical statistical indicators, interactive regression analysis, visual correlation mining, automated axis arrangements and filtering, and data classification techniques. The current work provides a detailed description of the system as well as a discussion of key design aspects and critical feedback from domain experts.

  7. Analytical framework for recurrence network analysis of time series.

    Science.gov (United States)

    Donges, Jonathan F; Heitzig, Jobst; Donner, Reik V; Kurths, Jürgen

    2012-04-01

    Recurrence networks are a powerful nonlinear tool for time series analysis of complex dynamical systems. While there are already many successful applications ranging from medicine to paleoclimatology, a solid theoretical foundation of the method has still been missing so far. Here, we interpret an ɛ-recurrence network as a discrete subnetwork of a "continuous" graph with uncountably many vertices and edges corresponding to the system's attractor. This step allows us to show that various statistical measures commonly used in complex network analysis can be seen as discrete estimators of newly defined continuous measures of certain complex geometric properties of the attractor on the scale given by ɛ. In particular, we introduce local measures such as the ɛ-clustering coefficient, mesoscopic measures such as ɛ-motif density, path-based measures such as ɛ-betweennesses, and global measures such as ɛ-efficiency. This new analytical basis for the so far heuristically motivated network measures also provides an objective criterion for the choice of ɛ via a percolation threshold, and it shows that estimation can be improved by so-called node splitting invariant versions of the measures. We finally illustrate the framework for a number of archetypical chaotic attractors such as those of the Bernoulli and logistic maps, periodic and two-dimensional quasiperiodic motions, and for hyperballs and hypercubes by deriving analytical expressions for the novel measures and comparing them with data from numerical experiments. More generally, the theoretical framework put forward in this work describes random geometric graphs and other networks with spatial constraints, which appear frequently in disciplines ranging from biology to climate science.

  8. Measuring diagnostic and predictive accuracy in disease management: an introduction to receiver operating characteristic (ROC) analysis.

    Science.gov (United States)

    Linden, Ariel

    2006-04-01

    Diagnostic or predictive accuracy concerns are common in all phases of a disease management (DM) programme, and ultimately play an influential role in the assessment of programme effectiveness. Areas, such as the identification of diseased patients, predictive modelling of future health status and costs and risk stratification, are just a few of the domains in which assessment of accuracy is beneficial, if not critical. The most commonly used analytical model for this purpose is the standard 2 x 2 table method in which sensitivity and specificity are calculated. However, there are several limitations to this approach, including the reliance on a single defined criterion or cut-off for determining a true-positive result, use of non-standardized measurement instruments and sensitivity to outcome prevalence. This paper introduces the receiver operator characteristic (ROC) analysis as a more appropriate and useful technique for assessing diagnostic and predictive accuracy in DM. Its advantages include; testing accuracy across the entire range of scores and thereby not requiring a predetermined cut-off point, easily examined visual and statistical comparisons across tests or scores, and independence from outcome prevalence. Therefore the implementation of ROC as an evaluation tool should be strongly considered in the various phases of a DM programme.

  9. Dairy Analytics and Nutrient Analysis (DANA) Prototype System User Manual

    Energy Technology Data Exchange (ETDEWEB)

    Sam Alessi; Dennis Keiser

    2012-10-01

    This document is a user manual for the Dairy Analytics and Nutrient Analysis (DANA) model. DANA provides an analysis of dairy anaerobic digestion technology and allows users to calculate biogas production, co-product valuation, capital costs, expenses, revenue and financial metrics, for user customizable scenarios, dairy and digester types. The model provides results for three anaerobic digester types; Covered Lagoons, Modified Plug Flow, and Complete Mix, and three main energy production technologies; electricity generation, renewable natural gas generation, and compressed natural gas generation. Additional options include different dairy types, bedding types, backend treatment type as well as numerous production, and economic parameters. DANA’s goal is to extend the National Market Value of Anaerobic Digester Products analysis (informa economics, 2012; Innovation Center, 2011) to include a greater and more flexible set of regional digester scenarios and to provide a modular framework for creation of a tool to support farmer and investor needs. Users can set up scenarios from combinations of existing parameters or add new parameters, run the model and view a variety of reports, charts and tables that are automatically produced and delivered over the web interface. DANA is based in the INL’s analysis architecture entitled Generalized Environment for Modeling Systems (GEMS) , which offers extensive collaboration, analysis, and integration opportunities and greatly speeds the ability construct highly scalable web delivered user-oriented decision tools. DANA’s approach uses server-based data processing and web-based user interfaces, rather a client-based spreadsheet approach. This offers a number of benefits over the client-based approach. Server processing and storage can scale up to handle a very large number of scenarios, so that analysis of county, even field level, across the whole U.S., can be performed. Server based databases allow dairy and digester

  10. Launch Velocities in Successful Golf Putting: An Analytical Analysis

    Directory of Open Access Journals (Sweden)

    John F. Mahoney

    2017-04-01

    Full Text Available Background: This study is concerned with the special case of a putted ball intersecting a standard golf hole at its diameter. The velocity of the ball at the initial rim of the hole is termed the launch velocity and depending upon its value the ball may either be captured or it may escape capture by jumping over the hole. The critical value of the launch velocity (V is such that lesser values result in capture while greater values produce escape. Purpose: Since the value of the V entered prominently in some theoretical studies of putting, the aim of the current study is to provide an original re-evaluation of V and to contrast our results with existing results. Method: This analytical analysis relies on trigonometry in conjunction with Newtonian mechanics and the mathematics of projectiles. The results of a recent study into the mathematics of a bouncing ball which included the notions of restitution and friction were also employed in the analysis. Results: If bouncing and slipping do not occur when the ball hits the far rim of the hole our analysis produces a value of V of 1.356 m/s. When bouncing and slipping are present we find that V is at least 1.609 m/s but increases beyond this value as slipping and friction become greater. Useful relations which relate the dynamics and geometry of the ball to V are provided. Conclusion: Since ambient conditions may influence the extent of bounce and slippage we conjecture that the value of V is not unique.

  11. Compound-specific radiocarbon analysis - Analytical challenges and applications

    Science.gov (United States)

    Mollenhauer, G.; Rethemeyer, J.

    2009-01-01

    Within the last decades, techniques have become available that allow measurement of isotopic compositions of individual organic compounds (compound-specific isotope measurements). Most often the carbon isotopic composition of these compounds is studied, including stable carbon (δ13C) and radiocarbon (Δ14C) measurements. While compound-specific stable carbon isotope measurements are fairly simple, and well-established techniques are widely available, radiocarbon analysis of specific organic compounds is a more challenging method. Analytical challenges include difficulty obtaining adequate quantities of sample, tedious and complicated laboratory separations, the lack of authentic standards for measuring realistic processing blanks, and large uncertainties in values of Δ14C at small sample sizes. The challenges associated with sample preparation for compound-specific Δ14C measurements will be discussed in this contribution. Several years of compound-specific radiocarbon analysis have revealed that in most natural samples, purified organic compounds consist of heterogeneous mixtures of the same compound. These mixtures could derive from multiple sources, each having a different initial reservoir age but mixed in the same terminal reservoir, from a single source but mixed after deposition, or from a prokaryotic organism using variable carbon sources including mobilization of ancient carbon. These processes not only represent challenges to the interpretation of compound-specific radiocarbon data, but provide unique tools for the understanding of biogeochemical and sedimentological processes influencing the preserved organic geochemical records in marine sediments. We will discuss some examples where compound-specific radiocarbon analysis has provided new insights for the understanding of carbon source utilization and carbon cycling.

  12. Neutron activation analysis as analytical tool of environmental issue

    International Nuclear Information System (INIS)

    Otoshi, Tsunehiko

    2004-01-01

    Neutron activation analysis (NAA) ia applicable to the sample of wide range of research fields, such as material science, biology, geochemistry and so on. However, respecting the advantages of NAA, a sample with small amounts or a precious sample is the most suitable samples for NAA, because NAA is capable of trace analysis and non-destructive determination. In this paper, among these fields, NAA of atmospheric particulate matter (PM) sample is discussed emphasizing on the use of obtained data as an analytical tool of environmental issue. Concentration of PM in air is usually very low, and it is not easy to get vast amount of sample even using a high volume air sampling devise. Therefore, high sensitive NAA is suitable to determine elements in PM samples. Main components of PM is crust oriented silicate, and so on in rural/remote area, and carbonic materials and heavy metals are concentrated in PM in urban area, because of automobile exhaust and other anthropogenic emission source. Elemental pattern of PM reflects a condition of air around the monitoring site. Trends of air pollution can be traced by periodical monitoring of PM by NAA method. Elemental concentrations in air change by season. For example, crustal elements increase in dry season, and sea salts components increase their concentration when wind direction from sea is dominant. Elements that emitted from anthropogenic sources are mainly contained in fine portion of PM, and increase their concentration during winter season, when emission from heating system is high and air is stable. For further analysis and understanding of environmental issues, indicator elements for various emission sources, and elemental concentration ratios of some environmental samples and source portion assignment techniques are useful. (author)

  13. Using the Technology of the Confessional as an Analytical Resource: Four Analytical Stances Towards Research Interviews in Discourse Analysis

    Directory of Open Access Journals (Sweden)

    Brendan K. O'Rourke

    2007-05-01

    Full Text Available Among the various approaches that have developed from FOUCAULT's work is an Anglophone discourse analysis that has attempted to combine FOUCAULTian insights with the techniques of Conversation Analysis. An important current methodological issue in this discourse analytical approach is its theoretical preference for "naturally occurring" rather than research interview data. A FOUCAULTian perspective on the interview as a research instrument, questions the idea of "naturally-occurring discourse". The "technology of the confessional" operates, not only within research interviews, but permeates other interactions as well. Drawing on FOUCAULT does not dismiss the problems of the interview as research instrument rather it shows they cannot be escaped by simply switching to more "natural" interactions. Combining these insights with recent developments within discourse analysis can provide analytical resources for, rather than barriers to, the discourse analysis of research interviews. To aid such an approach, we develop a four-way categorisation of analytical stances towards the research interview in discourse analysis. A demonstration of how a research interview might be subjected to a discourse analysis using elements of this approach is then provided. URN: urn:nbn:de:0114-fqs070238

  14. Design, demonstration and analysis of a modified wavelength-correlating receiver for incoherent OCDMA system.

    Science.gov (United States)

    Zhou, Heng; Qiu, Kun; Wang, Leyang

    2011-03-28

    A novel wavelength-correlating receiver for incoherent Optical Code Division Multiple Access (OCDMA) system is proposed and demonstrated in this paper. Enabled by the wavelength conversion based scheme, the proposed receiver can support various code types including one-dimensional optical codes and time-spreading/wavelength-hopping two dimensional codes. Also, a synchronous detection scheme with time-to- wavelength based code acquisition is proposed, by which code acquisition time can be substantially reduced. Moreover, a novel data-validation methodology based on all-optical pulse-width monitoring is introduced for the wavelength-correlating receiver. Experimental demonstration of the new proposed receiver is presented and low bit error rate data-receiving is achieved without optical hard limiting and electronic power thresholding. For the first time, a detailed theoretical performance analysis specialized for the wavelength-correlating receiver is presented. Numerical results show that the overall performance of the proposed receiver prevails over conventional OCDMA receivers.

  15. Microplasmas for chemical analysis: analytical tools or research toys?

    International Nuclear Information System (INIS)

    Karanassios, Vassili

    2004-01-01

    An overview of the activities of the research groups that have been involved in fabrication, development and characterization of microplasmas for chemical analysis over the last few years is presented. Microplasmas covered include: miniature inductively coupled plasmas (ICPs); capacitively coupled plasmas (CCPs); microwave-induced plasmas (MIPs); a dielectric barrier discharge (DBD); microhollow cathode discharge (MCHD) or microstructure electrode (MSE) discharges, other microglow discharges (such as those formed between 'liquid' electrodes); microplasmas formed in micrometer-diameter capillary tubes for gas chromatography (GC) or high-performance liquid chromatography (HPLC) applications, and a stabilized capacitive plasma (SCP) for GC applications. Sample introduction into microplasmas, in particular, into a microplasma device (MPD), battery operation of a MPD and of a mini- in-torch vaporization (ITV) microsample introduction system for MPDs, and questions of microplasma portability for use on site (e.g., in the field) are also briefly addressed using examples of current research. To emphasize the significance of sample introduction into microplasmas, some previously unpublished results from the author's laboratory have also been included. And an overall assessment of the state-of-the-art of analytical microplasma research is provided

  16. Image analysis driven single-cell analytics for systems microbiology.

    Science.gov (United States)

    Balomenos, Athanasios D; Tsakanikas, Panagiotis; Aspridou, Zafiro; Tampakaki, Anastasia P; Koutsoumanis, Konstantinos P; Manolakos, Elias S

    2017-04-04

    Time-lapse microscopy is an essential tool for capturing and correlating bacterial morphology and gene expression dynamics at single-cell resolution. However state-of-the-art computational methods are limited in terms of the complexity of cell movies that they can analyze and lack of automation. The proposed Bacterial image analysis driven Single Cell Analytics (BaSCA) computational pipeline addresses these limitations thus enabling high throughput systems microbiology. BaSCA can segment and track multiple bacterial colonies and single-cells, as they grow and divide over time (cell segmentation and lineage tree construction) to give rise to dense communities with thousands of interacting cells in the field of view. It combines advanced image processing and machine learning methods to deliver very accurate bacterial cell segmentation and tracking (F-measure over 95%) even when processing images of imperfect quality with several overcrowded colonies in the field of view. In addition, BaSCA extracts on the fly a plethora of single-cell properties, which get organized into a database summarizing the analysis of the cell movie. We present alternative ways to analyze and visually explore the spatiotemporal evolution of single-cell properties in order to understand trends and epigenetic effects across cell generations. The robustness of BaSCA is demonstrated across different imaging modalities and microscopy types. BaSCA can be used to analyze accurately and efficiently cell movies both at a high resolution (single-cell level) and at a large scale (communities with many dense colonies) as needed to shed light on e.g. how bacterial community effects and epigenetic information transfer play a role on important phenomena for human health, such as biofilm formation, persisters' emergence etc. Moreover, it enables studying the role of single-cell stochasticity without losing sight of community effects that may drive it.

  17. ANAlyte: A modular image analysis tool for ANA testing with indirect immunofluorescence.

    Science.gov (United States)

    Di Cataldo, Santa; Tonti, Simone; Bottino, Andrea; Ficarra, Elisa

    2016-05-01

    The automated analysis of indirect immunofluorescence images for Anti-Nuclear Autoantibody (ANA) testing is a fairly recent field that is receiving ever-growing interest from the research community. ANA testing leverages on the categorization of intensity level and fluorescent pattern of IIF images of HEp-2 cells to perform a differential diagnosis of important autoimmune diseases. Nevertheless, it suffers from tremendous lack of repeatability due to subjectivity in the visual interpretation of the images. The automatization of the analysis is seen as the only valid solution to this problem. Several works in literature address individual steps of the work-flow, nonetheless integrating such steps and assessing their effectiveness as a whole is still an open challenge. We present a modular tool, ANAlyte, able to characterize a IIF image in terms of fluorescent intensity level and fluorescent pattern without any user-interactions. For this purpose, ANAlyte integrates the following: (i) Intensity Classifier module, that categorizes the intensity level of the input slide based on multi-scale contrast assessment; (ii) Cell Segmenter module, that splits the input slide into individual HEp-2 cells; (iii) Pattern Classifier module, that determines the fluorescent pattern of the slide based on the pattern of the individual cells. To demonstrate the accuracy and robustness of our tool, we experimentally validated ANAlyte on two different public benchmarks of IIF HEp-2 images with rigorous leave-one-out cross-validation strategy. We obtained overall accuracy of fluorescent intensity and pattern classification respectively around 85% and above 90%. We assessed all results by comparisons with some of the most representative state of the art works. Unlike most of the other works in the recent literature, ANAlyte aims at the automatization of all the major steps of ANA image analysis. Results on public benchmarks demonstrate that the tool can characterize HEp-2 slides in terms of

  18. Unifying Approach to Analytical Chemistry and Chemical Analysis: Problem-Oriented Role of Chemical Analysis.

    Science.gov (United States)

    Pardue, Harry L.; Woo, Jannie

    1984-01-01

    Proposes an approach to teaching analytical chemistry and chemical analysis in which a problem to be resolved is the focus of a course. Indicates that this problem-oriented approach is intended to complement detailed discussions of fundamental and applied aspects of chemical determinations and not replace such discussions. (JN)

  19. Analytical Master Plan for the analysis of the data from the electric utility rate demonstration projects

    Energy Technology Data Exchange (ETDEWEB)

    1978-06-01

    The Federal Energy Administration (now the US Department of Energy), in cooperation with state public utility commissions and participating utilities, has initiated 16 electric utility rate demonstration projects. The primary purpose of these projects was to evaluate experimentally the effects of time-of-use pricing of electricity for residential customers. The time-of-use rate most frequently employed was a time-of-day (TOD) rate. The method employed by the states to evaluate TOD rates was to select a subset of the residential population, place these people on TOD rates, and with special meters, monitor their temporal use of electricity. As might be expected, with the varying objectives of the states, available resources, and background in load management studies, a variety of approaches were employed, and a variety of data generated by the projects. Also, the received and expected analyses of the data vary considerably among the projects due to the differing interests of the states, available resources, and the composition of the project teams. The three purposes of this Analytical Master Plan (AMP) are: to ensure the data derived from the FEA projects and from related sources are subjected to econometric and statistical analysis that is both rigorous and as highly sophisticated as the state of the art will permit; to ensure that the results of the analysis are organized and displayed in a manner useful to utility and regulatory decision-makers; and to ensure that the analytical effort is conducted on a timely and professional basis. This report identifies the alternative analytical approaches, project specific analyses, project-pooled analyses and organization and management plan for completing the study. Synopses of all the demonstration projects are presented in the appendixes which are bound separately in Volume II.

  20. An analysis of referrals received by a psychiatric unit in a general ...

    African Journals Online (AJOL)

    An analysis of referrals received by a psychiatric unit in a general hospital part 1: the need for and research design adopted to study referrals received by a psychiatric unit in a general hospital: research. M. Dor, V.J. Ehlers, M.M. Van der Merwe ...

  1. An integrated approach to grey relational analysis, analytic hierarchy process and data envelopment analysis

    OpenAIRE

    Pakkar, Mohammad Sadegh

    2017-01-01

    Purpose: This paper aims to propose an integration of the analytic hierarchy process (AHP) and data envelopment analysis (DEA) methods in a multiattribute grey relational analysis (GRA) methodology in which the attribute weights are completely unknown and the attribute values take the form of fuzzy numbers. Design/methodology/approach: This research has been organized to proceed along the following steps: computing the grey relational coefficients for alternatives with respect to each attribu...

  2. Analytical Model for High Impedance Fault Analysis in Transmission Lines

    Directory of Open Access Journals (Sweden)

    S. Maximov

    2014-01-01

    Full Text Available A high impedance fault (HIF normally occurs when an overhead power line physically breaks and falls to the ground. Such faults are difficult to detect because they often draw small currents which cannot be detected by conventional overcurrent protection. Furthermore, an electric arc accompanies HIFs, resulting in fire hazard, damage to electrical devices, and risk with human life. This paper presents an analytical model to analyze the interaction between the electric arc associated to HIFs and a transmission line. A joint analytical solution to the wave equation for a transmission line and a nonlinear equation for the arc model is presented. The analytical model is validated by means of comparisons between measured and calculated results. Several cases of study are presented which support the foundation and accuracy of the proposed model.

  3. A Methodology for Project Selection Using Economic Analysis and the Analytic Hierarchy Process

    Science.gov (United States)

    1992-09-01

    x I. Introduction ...................... ....................... 1 Capital Budgeting and the Analytic Hierarchy Process ............ ............. 1...applicability of a multiple criterion decision making ( MCDM ) method, known as the Analytic Hierarchy Process (AHP), to economic analysis decisions involving...economic analysis of projects. Several MCDM methods were examined and the AHP was found to be the most promising technique to rate projects on a ratio scale

  4. Hair elemental analysis for forensic science using nuclear and related analytical methods

    Czech Academy of Sciences Publication Activity Database

    Kučera, Jan; Kameník, Jan; Havránek, Vladimír

    2018-01-01

    Roč. 7, č. 3 (2018), s. 65-74 ISSN 2468-1709 R&D Projects: GA ČR(CZ) GBP108/12/G108; GA MŠk LM2015056 Institutional support: RVO:61389005 Keywords : hair * forensic analysis * neutron activation analysis * particle induced X-ray emission Subject RIV: CB - Analytical Chemistry, Separation OBOR OECD: Analytical chemistry

  5. Analytical travelling wave solutions and parameter analysis for the ...

    Indian Academy of Sciences (India)

    By using dynamical system method, this paper considers the (2+1)-dimensional Davey–Stewartson-type equations. The analytical parametric representations of solitary wave solutions, periodic wave solutions as well as unbounded wave solutions are obtained under different parameter conditions. A few diagrams ...

  6. Reflections on the nature of analysis and some analytical skills ...

    African Journals Online (AJOL)

    Acknowledging the uniqueness of number and space alongside their mutual coherence serves to illustrate what a non-reductionist ontology means. This digression opens up the possibility to illustrate the nature of analytical skills by arguing that the arithmeticistic claims of modern set theory begs the question (it assumes ...

  7. Analytical travelling wave solutions and parameter analysis for the

    Indian Academy of Sciences (India)

    By using dynamical system method, this paper considers the (2+1)-dimensional Davey–Stewartson-type equations. The analytical parametric representations of solitary wave solutions, periodic wave solutions as well as unbounded wave solutions are obtained under different parameter conditions. A few diagrams ...

  8. Nonlinear analysis of doubly curved shells: An analytical approach

    Indian Academy of Sciences (India)

    is a time-honoured need to have an efficient analytical methodology of solution, which could serve as a bench-mark solution for the numerical methods. Chebyshev polynomials are orthogonal functions and have the property of minimax (Fox & Parker 1968). The. Sa┼dhana┼, Vol. 25, Part 4, August 2000, pp. 343±352.

  9. Chemometrics in analytical chemistry-part I: history, experimental design and data analysis tools.

    Science.gov (United States)

    Brereton, Richard G; Jansen, Jeroen; Lopes, João; Marini, Federico; Pomerantsev, Alexey; Rodionova, Oxana; Roger, Jean Michel; Walczak, Beata; Tauler, Romà

    2017-10-01

    Chemometrics has achieved major recognition and progress in the analytical chemistry field. In the first part of this tutorial, major achievements and contributions of chemometrics to some of the more important stages of the analytical process, like experimental design, sampling, and data analysis (including data pretreatment and fusion), are summarised. The tutorial is intended to give a general updated overview of the chemometrics field to further contribute to its dissemination and promotion in analytical chemistry.

  10. CFD analysis of supercritical CO2 used as HTF in a solar tower receiver

    Science.gov (United States)

    Roldán, M. I.; Fernández-Reche, J.

    2016-05-01

    The relative cost of a solar receiver can be minimized by the selection of an appropriate heat transfer fluid capable of achieving high receiver efficiencies. In a conventional central receiver system, the concentrated solar energy is transferred from the receiver tube walls to the heat transfer fluid (HTF), which passes through a heat exchanger to generate steam for a Rankine cycle. Thus, higher working fluid temperature is associated with greater efficiency in receiver and power cycle. Emerging receiver designs that can enable higher efficiencies using advanced power cycles, such as supercritical CO2 (s-CO2) closed-loop Brayton cycles, include direct heating of s-CO2 in tubular receiver designs capable of withstanding high internal fluid pressures (around 20 MPa) and temperatures (900 K). Due to the high pressures required and the presence of moving components installed in pipelines (ball-joints and/or flexible connections), the use of s-CO2 presents many technical challenges due to the compatibility of seal materials and fluid leakages of the moving connections. These problems are solved in solar tower systems because the receiver is fixed. In this regard, a preliminary analysis of a tubular receiver with s-CO2 as HTF has been developed using the design of a molten-salt receiver which was previously tested at Plataforma Solar de Almería (PSA). Therefore, a simplified CFD model has been carried out in this study in order to analyze the feasibility of s-CO2 as HTF in solar towers. Simulation results showed that the heat gained by s-CO2 was around 75% greater than the one captured by molten salts (fluid inlet temperature of 715 K), but at a pressure range of 7.5-9.7 MPa. Thus, the use of s-CO2 as HTF in solar tower receivers appears to be a promising alternative, taking into account both the operating conditions required and their maintenance cost.

  11. Marketing Mix Formulation for Higher Education: An Integrated Analysis Employing Analytic Hierarchy Process, Cluster Analysis and Correspondence Analysis

    Science.gov (United States)

    Ho, Hsuan-Fu; Hung, Chia-Chi

    2008-01-01

    Purpose: The purpose of this paper is to examine how a graduate institute at National Chiayi University (NCYU), by using a model that integrates analytic hierarchy process, cluster analysis and correspondence analysis, can develop effective marketing strategies. Design/methodology/approach: This is primarily a quantitative study aimed at…

  12. Analytical analysis and experimental verification of interleaved parallelogram heat sink

    International Nuclear Information System (INIS)

    Chen, Hong-Long; Wang, Chi-Chuan

    2017-01-01

    Highlights: • A novel air-cooled heat sink profile (IPFM) is proposed to compete with the typical design. • It features two different perimeters with odd fin being rectangular and the rest being parallelogram. • A new modified dimensionless parameter characterized the flow length in triangular region is proposed. • The analytical predictions are in line with the experiments for both conventional and IPFM design. • IPFM design shows a much lower pressure drop and a superior performance especially for dense fins. - Abstract: In this study, a novel air-cooled heat sink profile is proposed to compete with the conventional design. The new design is termed as IPFM (Interleaved Parallelogram Fin Module) which features two different geometrical perimeter shapes of fins. This new design not only gains the advantage of lower pressure drop for power saving; but also gains a material saving for less fin surface area. An assessment of flow impedance and performance between the conventional and IPFM heat sink is analytically investigated and experimentally verified. A new modified dimensionless friction factor for triangular region is proposed. The analytical predictions agree with experimental measurements for both conventional and IPFM design. In electronic cooling design, especially for cloud server air-cooled heat sink design, the flow pattern is usually laminar with Reynolds number being operated less than 2000. In this regime, the IPFM design shows 8–12% less of surface than conventional design when the flow rate is less than 10 CFM; yet the thermal performance is slightly inferior to the conventional design when the flowrate is raised towards 25 CFM. Yet in the test range of 5–25 CFM, a 10–15% lower flow impedance is observed. The smaller fin spacing, the more conspicuous reduction of flow impedance is observed. The optimization of cutting angle is around 35° for 10 CFM, and it is reduced to 15° at a larger flowrate of 20 CFM.

  13. Analytical method for thermal stress analysis of plasma facing materials

    International Nuclear Information System (INIS)

    You, J.H.; Bolt, H.

    2001-01-01

    The thermo-mechanical response of plasma facing materials (PFMs) to heat loads from the fusion plasma is one of the crucial issues in fusion technology. In this work, a fully analytical description of the thermal stress distribution in armour tiles of plasma facing components is presented which is expected to occur under typical high heat flux (HHF) loads. The method of stress superposition is applied considering the temperature gradient and thermal expansion mismatch. Several combinations of PFMs and heat sink metals are analysed and compared. In the framework of the present theoretical model, plastic flow and the effect of residual stress can be quantitatively assessed. Possible failure features are discussed

  14. Analytical method for thermal stress analysis of plasma facing materials

    Science.gov (United States)

    You, J. H.; Bolt, H.

    2001-10-01

    The thermo-mechanical response of plasma facing materials (PFMs) to heat loads from the fusion plasma is one of the crucial issues in fusion technology. In this work, a fully analytical description of the thermal stress distribution in armour tiles of plasma facing components is presented which is expected to occur under typical high heat flux (HHF) loads. The method of stress superposition is applied considering the temperature gradient and thermal expansion mismatch. Several combinations of PFMs and heat sink metals are analysed and compared. In the framework of the present theoretical model, plastic flow and the effect of residual stress can be quantitatively assessed. Possible failure features are discussed.

  15. Analytic Analysis of Convergent Shocks to Multi-Gigabar Conditions

    Science.gov (United States)

    Ruby, J. J.; Rygg, J. R.; Collins, G. W.; Bachmann, B.; Doeppner, T.; Ping, Y.; Gaffney, J.; Lazicki, A.; Kritcher, A. L.; Swift, D.; Nilsen, J.; Landen, O. L.; Hatarik, R.; Masters, N.; Nagel, S.; Sterne, P.; Pardini, T.; Khan, S.; Celliers, P. M.; Patel, P.; Gericke, D.; Falcone, R.

    2017-10-01

    The gigabar experimental platform at the National Ignition Facility is designed to increase understanding of the physical states and processes that dominate in the hydrogen at pressures from several hundreds of Mbar to tens of Gbar. Recent experiments using a solid CD2 ball reached temperatures and densities of order 107 K and several tens of g/cm3 , respectively. These conditions lead to the production of D-D fusion neutrons and x-ray bremsstrahlung photons, which allow us to place constraints on the thermodynamic states at peak compression. We use an analytic model to connect the neutron and x-ray emission with the state variables at peak compression. This analytic model is based on the self-similar Guderley solution of an imploding shock wave and the self-similar solution of the point explosion with heat conduction from Reinicke. Work is also being done to create a fully self-similar solution of an imploding shock wave coupled with heat conduction and radiation transport using a general equation of state. This material is based upon work supported by the Department of Energy National Nuclear Security Administration under Award Number DE-NA0001944.

  16. Archetypal facets: analysis of clinical case supporting the Analytical Psychology

    Directory of Open Access Journals (Sweden)

    Odéssia Fernanda Gomes de Assis

    2016-01-01

    Full Text Available This paper is a case study of a patient who came to us complaining of difficulties within the family due to the fact that he could not deny anything to people. The case was analyzed based on the framework of Analytical Psychology, founded mainly on Carl Gustav Jung. Psychological counseling sessions were held, and after the sessions, theoretical approaches have been made based on the material presented by the patient. The interventions were performed with the goal of enabling the patient and insights she sought other ways to position themselves in the world and to relate to the people around. Over the course of the sessions, the patient was able to construct a context in which allow and deny more in accordance with their abilities and possibilities.

  17. Analytical capabilities of RIMS: absolute sensitivity and isotopic analysis

    International Nuclear Information System (INIS)

    Nogar, N.S.; Downey, S.W.; Miller, C.M.

    1984-01-01

    Resonance ionization mass spectrometry (RIMS) with thermal filament sources is becoming an established analytical technique. The results of recent isotope ratio measurements carried out on small (60 - 200ng) lutetium samples are presented. The sensitivity and selectivity of continuous wave (CW) laser RIMS allow the accurate determination of very large ratios (approx. 10 6 ) in real samples containing numerous isobaric interferences. In addition, high resolution optical spectra of lutetium isotopes have been generated using RIMS as a prelude to isotopically selective resonance ionization. Also, the results of two-color spectroscopic studies for isotope ratio measurements in technetium are presented. A large number of multiply-resonant sequences have been explored; however, the presence of Tc molecular species appears to limit the potential sensitivity of the measurement. (author)

  18. Analysis III analytic and differential functions, manifolds and Riemann surfaces

    CERN Document Server

    Godement, Roger

    2015-01-01

    Volume III sets out classical Cauchy theory. It is much more geared towards its innumerable applications than towards a more or less complete theory of analytic functions. Cauchy-type curvilinear integrals are then shown to generalize to any number of real variables (differential forms, Stokes-type formulas). The fundamentals of the theory of manifolds are then presented, mainly to provide the reader with a "canonical'' language and with some important theorems (change of variables in integration, differential equations). A final chapter shows how these theorems can be used to construct the compact Riemann surface of an algebraic function, a subject that is rarely addressed in the general literature though it only requires elementary techniques. Besides the Lebesgue integral, Volume IV will set out a piece of specialized mathematics towards which the entire content of the previous volumes will converge: Jacobi, Riemann, Dedekind series and infinite products, elliptic functions, classical theory of modular fun...

  19. Performance Analysis of Receive Diversity in Wireless Sensor Networks over GBSBE Models

    Directory of Open Access Journals (Sweden)

    Tai-hoon Kim

    2010-12-01

    Full Text Available Wireless sensor networks have attracted a lot of attention recently. In this paper, we develop a channel model based on the elliptical model for multipath components involving randomly placed scatterers in the scattering region with sensors deployed on a field. We verify that in a sensor network, the use of receive diversity techniques improves the performance of the system. Extensive performance analysis of the system is carried out for both single and multiple antennas with the applied receive diversity techniques. Performance analyses based on variations in receiver height, maximum multipath delay and transmit power have been performed considering different numbers of antenna elements present in the receiver array, Our results show that increasing the number of antenna elements for a wireless sensor network does indeed improve the BER rates that can be obtained.

  20. Analytical sensitivity analysis of geometric errors in a three axis machine tool

    International Nuclear Information System (INIS)

    Park, Sung Ryung; Yang, Seung Han

    2012-01-01

    In this paper, an analytical method is used to perform a sensitivity analysis of geometric errors in a three axis machine tool. First, an error synthesis model is constructed for evaluating the position volumetric error due to the geometric errors, and then an output variable is defined, such as the magnitude of the position volumetric error. Next, the global sensitivity analysis is executed using an analytical method. Finally, the sensitivity indices are calculated using the quantitative values of the geometric errors

  1. Meta-analysis as Statistical and Analytical Method of Journal's Content Scientific Evaluation.

    Science.gov (United States)

    Masic, Izet; Begic, Edin

    2015-02-01

    A meta-analysis is a statistical and analytical method which combines and synthesizes different independent studies and integrates their results into one common result. Analysis of the journals "Medical Archives", "Materia Socio Medica" and "Acta Informatica Medica", which are located in the most eminent indexed databases of the biomedical milieu. The study has retrospective and descriptive character, and included the period of the calendar year 2014. Study included six editions of all three journals (total of 18 journals). In this period was published a total of 291 articles (in the "Medical Archives" 110, "Materia Socio Medica" 97, and in "Acta Informatica Medica" 84). The largest number of articles was original articles. Small numbers have been published as professional, review articles and case reports. Clinical events were most common in the first two journals, while in the journal "Acta Informatica Medica" belonged to the field of medical informatics, as part of pre-clinical medical disciplines. Articles are usually required period of fifty to fifty nine days for review. Articles were received from four continents, mostly from Europe. The authors are most often from the territory of Bosnia and Herzegovina, then Iran, Kosovo and Macedonia. The number of articles published each year is increasing, with greater participation of authors from different continents and abroad. Clinical medical disciplines are the most common, with the broader spectrum of topics and with a growing number of original articles. Greater support of the wider scientific community is needed for further development of all three of the aforementioned journals.

  2. An Analytic Hierarchy Process Analysis: Application to Subscriber Retention Decisions in the Nigerian Mobile Telecommunications

    Directory of Open Access Journals (Sweden)

    Adebiyi Sulaimon Olanrewaju

    2015-12-01

    Full Text Available The introduction of mobile number portability (MNP in the Nigerian telecommunications industry has brought a new challenge for mobile operators. This study investigates the use of Analytic Hierarchy Process (AHP in customer retention decisions in the Nigerian telecommunication industry using a cross-sectional survey design. Primary data were obtained through questionnaires administered to 480 mobile telecommunications subscribers in six tertiary institutions located in Lagos State, Nigeria. These educational institutions were chosen using a multistage sampling technique. Of 438 questionnaires received from subscribers, 408 were valid. Based on this sample data an AHP model was built to assess the determinants of customer retention decisions. Next, eigen values, an eigen vector and maximum lambda (λMax were obtained using the AHP analysis for the matrices. This analysis shows that customers considered call quality as the important in the retention decision. We conclude that AHP is a meaningful tool for determining what motivates retention decisions, that can help network operators formulate effective customer retention strategies.

  3. Power and Efficiency Analysis of a Solar Central Receiver Combined Cycle Plant with a Small Particle Heat Exchanger Receiver

    Science.gov (United States)

    Virgen, Matthew Miguel

    Two significant goals in solar plant operation are lower cost and higher efficiencies. To achieve those goals, a combined cycle gas turbine (CCGT) system, which uses the hot gas turbine exhaust to produce superheated steam for a bottoming Rankine cycle by way of a heat recovery steam generator (HRSG), is investigated in this work. Building off of a previous gas turbine model created at the Combustion and Solar Energy Laboratory at SDSU, here are added the HRSG and steam turbine model, which had to handle significant change in the mass flow and temperature of air exiting the gas turbine due to varying solar input. A wide range of cases were run to explore options for maximizing both power and efficiency from the proposed CSP CCGT plant. Variable guide vanes (VGVs) were found in the earlier model to be an effective tool in providing operational flexibility to address the variable nature of solar input. Combined cycle efficiencies in the range of 50% were found to result from this plant configuration. However, a combustor inlet temperature (CIT) limit leads to two distinct Modes of operation, with a sharp drop in both plant efficiency and power occurring when the air flow through the receiver exceeded the CIT limit. This drawback can be partially addressed through strategic use of the VGVs. Since system response is fully established for the relevant range of solar input and variable guide vane angles, the System Advisor Model (SAM) from NREL can be used to find what the actual expected solar input would be over the course of the day, and plan accordingly. While the SAM software is not yet equipped to model a Brayton cycle cavity receiver, appropriate approximations were made in order to produce a suitable heliostat field to fit this system. Since the SPHER uses carbon nano-particles as the solar absorbers, questions of particle longevity and how the particles might affect the flame behavior in the combustor were addressed using the chemical kinetics software Chemkin

  4. Analysis of RNA by analytical polyacrylamide gel electrophoresis.

    Science.gov (United States)

    Petrov, Alexey; Tsa, Albet; Puglisi, Joseph D

    2013-01-01

    Polyacrylamide gel electrophoresis (PAGE) is a powerful tool for analyzing RNA samples. Denaturing PAGE provides information on the sample composition and structural integrity of the individual RNA species. Nondenaturing gel electrophoresis allows separation of the conformers and alternatively folded RNA species. It also can be used to resolve RNA protein complexes and to detect RNA complex formation by analyzing changes in the electrophoretic mobility of the RNA. RNA can be visualized within gels by different methods depending on the nature of the detection reagent. RNA molecules can be stained with various dyes, including toluidine blue, SYBR green, and ethidium bromide. Radioactively labeled RNA molecules are visualized by autoradiography, and fluorescently labeled RNA molecules can be observed with a fluorescence scanner. Generally, gels between 0.4 and 1.5mm thick are used for analytical PAGE. Gels thinner than 1mm are fragile and thus usually are not stained but rather are used for radiolabeled RNA. The gels are dried and the radiolabeled RNA is visualized by autoradiography. © 2013 Elsevier Inc. All rights reserved.

  5. Real-time analysis of healthcare using big data analytics

    Science.gov (United States)

    Basco, J. Antony; Senthilkumar, N. C.

    2017-11-01

    Big Data Analytics (BDA) provides a tremendous advantage where there is a need of revolutionary performance in handling large amount of data that covers 4 characteristics such as Volume Velocity Variety Veracity. BDA has the ability to handle such dynamic data providing functioning effectiveness and exceptionally beneficial output in several day to day applications for various organizations. Healthcare is one of the sectors which generate data constantly covering all four characteristics with outstanding growth. There are several challenges in processing patient records which deals with variety of structured and unstructured format. Inducing BDA in to Healthcare (HBDA) will deal with sensitive patient driven information mostly in unstructured format comprising of prescriptions, reports, data from imaging system, etc., the challenges will be overcome by big data with enhanced efficiency in fetching and storing of data. In this project, dataset alike Electronic Medical Records (EMR) produced from numerous medical devices and mobile applications will be induced into MongoDB using Hadoop framework with Improvised processing technique to improve outcome of processing patient records.

  6. OSD Perspective - Analytic Challenge: Global War on Terror Analysis

    Science.gov (United States)

    2007-06-01

    PMESII-TBD ITEM, THUNDER SOF Behavioral Analysis Tool ( Pythagoras ) Information Operations...US Pythagoras Interim Semi-static Stability Model Unconventional Warfare PMESII-TBD JTLS JTLS Civil Affairs Operations System Dynamics...JICM SOF Behavioral Analysis Tool ( Pythagoras ) Psychological Operations Direct Combat Model (JCATS

  7. Security analysis - from analytical methods to intelligent systems

    Energy Technology Data Exchange (ETDEWEB)

    Lambert-Torres, G.; Silva, A.P. Alves da; Ferreira, C. [Escola Federal de Engenharia de Itajuba, MG (Brazil); Mattos dos Reis, L.O. [Taubate Univ., SP (Brazil)

    1994-12-31

    This paper presents an alternative approach to Security Analysis based on Artificial Neural Network (ANN) techniques. This new technique tries to imitate the human brain and is based on neurons and synopses. A critical review of the ANN used in Power System Operation problem solving is made, while structures to solve the Security Analysis problems are proposed. (author) 7 refs., 4 figs.

  8. Discovering Hidden Controlling Parameters using Data Analytics and Dimensional Analysis

    Science.gov (United States)

    Del Rosario, Zachary; Lee, Minyong; Iaccarino, Gianluca

    2017-11-01

    Dimensional Analysis is a powerful tool, one which takes a priori information and produces important simplifications. However, if this a priori information - the list of relevant parameters - is missing a relevant quantity, then the conclusions from Dimensional Analysis will be incorrect. In this work, we present novel conclusions in Dimensional Analysis, which provide a means to detect this failure mode of missing or hidden parameters. These results are based on a restated form of the Buckingham Pi theorem that reveals a ridge function structure underlying all dimensionless physical laws. We leverage this structure by constructing a hypothesis test based on sufficient dimension reduction, allowing for an experimental data-driven detection of hidden parameters. Both theory and examples will be presented, using classical turbulent pipe flow as the working example. Keywords: experimental techniques, dimensional analysis, lurking variables, hidden parameters, buckingham pi, data analysis. First author supported by the NSF GRFP under Grant Number DGE-114747.

  9. Cluster Analytical Method of Fault Risk Analysis in Systems

    Science.gov (United States)

    Michaľčonok, German; Horalová Kalinová, Michaela

    2016-12-01

    In providing safety functions, the proposal of safety functions of control systems is an important part of a risk reduction strategy. In the specification of security requirements, it is necessary to determine and document individual characteristics and the desired performance level for each safety. This article presents the results of the experiment cluster analysis. The results of the experiment prove that the methods of cluster analysis provide a suitable tool for analyzing the reliability of safety systems analysis. Regarding the increasing complexity of the systems, we can state that the application of these methods in the subject area is a good choice.

  10. Analytical kinematics analysis and synthesis of planar mechanisms

    CERN Document Server

    Gans, Deborah

    2013-01-01

    Using computational techniques and a complex variable formulation, this book teaches the student of kinematics to handle increasingly difficult problems in both the analysis and design of mechanisms all based on the fundamental loop closure equation.

  11. Thermal Analysis of Direct Liquid-Immersed Solar Receiver for High Concentrating Photovoltaic System

    Directory of Open Access Journals (Sweden)

    Xinyue Han

    2015-01-01

    Full Text Available Concentrator solar cells that operate at high solar concentration level must be cooled. In this paper, direct liquid immersion cooling of triple-junction solar cells (InGaP/InGaAs/Ge is proposed as a heat dissipation solution for dense-array high concentrating photovoltaic (HCPV systems. The advantages of triple-junction CPV cells immersed in a circulating dielectric liquid and dish HCPV technology are integrated into a CPV system to improve the system electrical conversion efficiency. An analytical model for the direct liquid-immersed solar receiver with triple-junction CPV cells is presented. The main outputs of the model are the components temperatures of the receiver and the system electrical efficiency. The influence of concentration factor, mass flow rate, and inlet liquid temperature on the operating temperature of the triple-junction CPV cells and the system electrical conversion efficiency are discussed. It is shown that the system electrical conversion efficiency is very high for a wide range of operating conditions. The three operating parameters have a major effect on the operating temperature of the triple-junction CPV cells and, by extension, system output power. The flow rate selection should match concentration factor to keep the triple-junction CPV cells temperature lower and increase the electrical conversion efficiency of the dense-array HCPV system.

  12. Solar power generation by use of Stirling engine and heat loss analysis of its cavity receiver

    Science.gov (United States)

    Hussain, Tassawar

    position (AP=H/D) were used to characterize the different configurations of Cavity Receiver and it was found that the Cavity Receiver with AR=0.5 and AP=0.53 has the maximum capability to utilize the solar heat to attain the maximum temperature of the heat pipe receiver. Experimental heat loss analysis at low temperature for different configurations of the cavity receiver was performed and air film temperature profiles along the wall height (H) of the cavity receiver were determined. Since sodium heat pipes operate at high temperature (973K), there are huge possibilities of radiation and convection heat losses for direct solar heating of the heater head. Therefore mathematical modeling of heat loss analysis and its numerical solution at high temperature was also included in the research objectives. 2-D axisymmetric model with weakly compressible Navier Stokes equation and general heat conduction and convection equations were simultaneously solved using the finite element method approach. Computational fluid dynamics package COMSOL 3.5a was used as a numerical tool. The temperature, and flow field pattern inside the cavity receiver were also visualized by means of surface contours. Heat loss analysis were performed for different configurations of Cavity Receiver and the numerical solution of different configuration showed that the aperture ratio (AR) plays a significant role for convection and radiation heat losses whereas the aperture position (AP) effects are negligible.

  13. Shotgun lipidomic analysis of chemically sulfated sterols compromises analytical sensitivity

    DEFF Research Database (Denmark)

    Casanovas, Albert; Hannibal-Bach, Hans Kristian; Jensen, Ole Nørregaard

    2014-01-01

    Shotgun lipidomics affords comprehensive and quantitative analysis of lipid species in cells and tissues at high-throughput [1 5]. The methodology is based on direct infusion of lipid extracts by electrospray ionization (ESI) combined with tandem mass spectrometry (MS/MS) and/or high resolution F...... low ionization efficiency in ESI [7]. For this reason, chemical derivatization procedures including acetylation [8] or sulfation [9] are commonly implemented to facilitate ionization, detection and quantification of sterols for global lipidome analysis [1-3, 10]....

  14. Stochastic Analysis of Offshore Steel Structures An Analytical Appraisal

    CERN Document Server

    Karadeniz, Halil

    2013-01-01

    Stochastic Analysis of Offshore Steel Structures provides a clear and detailed guide to advanced analysis methods of fixed offshore steel structures using 3D beam finite elements under random wave and earthquake loadings. Advanced and up-to-date research results are coupled with modern analysis methods and essential theoretical information to consider optimal solutions to structural issues. As these methods require and use knowledge of different subject matters, a general introduction to the key areas is provided. This is followed by in-depth explanations supported by design examples, relevant calculations and supplementary material containing related computer programmers. By combining this theoretical and practical approach Stochastic Analysis of Offshore Steel Structures cover a range of key concepts in detail including: ·         The basic principles of standard 3D beam finite elements and special connections, ·         Wave loading - from hydrodynamics to the calculation of wave load...

  15. Analytical Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — The Analytical Labspecializes in Oil and Hydraulic Fluid Analysis, Identification of Unknown Materials, Engineering Investigations, Qualification Testing (to support...

  16. COMPARATIVE ANALYSIS O F ANALYTICAL AND NUMERICAL SOLVING OF HEAT PROBLEM, WHICH USES THE HEAT CONDUCTION EQUATION

    Directory of Open Access Journals (Sweden)

    A. N. Chichko

    2007-01-01

    Full Text Available The numerical analysis of temperature field, being cooled under analytical and numerical schematic models, is carried out. It is shown that implicit schematic model is close to analytical decision.

  17. Experimental and numerical analysis of convective heat losses from spherical cavity receiver of solar concentrator

    Directory of Open Access Journals (Sweden)

    Shewale Vinod C.

    2017-01-01

    Full Text Available Spherical cavity receiver of solar concentrator is made up of Cu tubing material having cavity diameter 385 mm to analyze the different heat losses such as conduction, convection and radiation. As the convection loss plays major role in heat loss analysis of cavity receiver, the experimental analysis is carried out to study convective heat loss for the temperature range of 55-75°C at 0°, 15°, 30°, 45°, 60°, and 90° inclination angle of downward facing cavity receiver. The numerical analysis is carried out to study convective heat loss for the low temperature range (55-75°C as well as high temperature range (150-300 °C for no wind condition only. The experimental set-up mainly consists of spherical cavity receiver which is insulated with glass wool insulation to reduce the heat losses from outside surface. The numerical analysis is carried out by using CFD software and the results are compared with the experimental results and found good agreement. The result shows that the convective loss increases with decrease in cavity inclination angle and decreases with decrease in mean cavity receiver temperature. The maximum losses are obtained at 0° inclination angle and the minimum losses are obtained at 90° inclination angle of cavity due to increase in stagnation zone in to the cavity from 0° to 90° inclination. The Nusselt number correlation is developed for the low temperature range 55-75°C based on the experimental data. The analysis is also carried out to study the effect of wind speed and wind direction on convective heat losses. The convective heat losses are studied for two wind speeds (3 m/s and 5 m/s and four wind directions [α is 0° (Side-on wind, 30°, 60°, and 90° (head-on wind]. It is found that the convective heat losses for both wind speed are higher than the losses obtained by no wind test. The highest heat losses are found for wind direction α is 60° with respect to receiver stand and lowest heat losses are found

  18. The Power of Social Media Analytics: Text Analytics Based on Sentiment Analysis and Word Clouds on R

    Directory of Open Access Journals (Sweden)

    Ahmed Imran KABIR

    2018-01-01

    Full Text Available Apparently, word clouds have grown as a clear and appealing illustration or visualization strategy in terms of text. Word clouds are used as a part of various settings as a way to give a diagram by cleansing text throughout those words that come up with most frequently. Generally, this is performed constantly as an unadulterated text outline. In any case, that there is a bigger capability to this basic yet intense visualization worldview in text analytics. In this work, we investigate the adequacy of word clouds for general text analysis errands and also analyze the tweets to find out the sentiment and also discuss the legal aspects of text mining. We used R software to pull twitter data which depends altogether on word cloud as a visualization technique and also with the help of positive and negative words to determine the user sentiment. We indicate how this approach can be viably used to explain text analysis tasks and assess it in a qualitative user research.

  19. Preliminary Analysis of the CASES GPS Receiver Performance during Simulated Seismic Displacements

    Science.gov (United States)

    De la Rosa-Perkins, A.; Reynolds, A.; Crowley, G.; Azeem, I.

    2014-12-01

    We explore the ability of a new GPS software receiver, called CASES (Connected Autonomous Space Environment Sensor), to measure seismic displacements in realtime. Improvements in GPS technology over the last 20 years allow for precise measurement of ground motion during seismic events. For example, GPS data has been used to calculate displacement histories at an earthquake's epicenter and fault slip estimations with great accuracy. This is supported by the ability to measure displacements directly using GPS, bypassing the double integration that accelerometers require, and by higher clipping limits than seismometers. The CASES receiver developed by ASTRA in collaboration with Cornell University and the University of Texas, Austin represents a new geodetic-quality software-based GPS receiver that measures ionospheric space weather in addition to the usual navigation solution. To demonstrate, in a controlled environment, the ability of the CASES receiver to measure seismic displacements, we simulated ground motions similar to those generated during earthquakes, using a shake box instrumented with an accelerometer and a GPS antenna. The accelerometer measured the box's actual displacement. The box moved on a manually controlled axis that underwent varied one-dimensional motions (from mm to cm) at different frequencies and amplitudes. The CASES receiver was configured to optimize the accuracy of the position solution. We quantified the CASES GPS receiver performance by comparing the GPS solutions against the accelerometer data using various statistical analysis methods. The results of these tests will be presented. The CASES receiver is designed with multiple methods of accessing the data in realtime, ranging from internet connection, blue-tooth, cell-phone modem and Iridium modem. Because the CASES receiver measures ionospheric space weather in addition to the usual navigation solution, CASES provides not only the seimic signal, but also the ionospheric space weather

  20. Analytical validation of the CACECO containment analysis code

    International Nuclear Information System (INIS)

    Peak, R.D.

    1979-08-01

    The CACECO containment analysis code was developed to predict the thermodynamic responses of LMFBR containment facilities to a variety of accidents. This report covers the verification of the CACECO code by problems that can be solved by hand calculations or by reference to textbook and literature examples. The verification concentrates on the accuracy of the material and energy balances maintained by the code and on the independence of the four cells analyzed by the code so that the user can be assured that the code analyses are numerically correct and independent of the organization of the input data submitted to the code

  1. SplitRFLab: A MATLAB GUI toolbox for receiver function analysis based on SplitLab

    Science.gov (United States)

    Xu, Mijian; Huang, Hui; Huang, Zhouchuan; Wang, Liangshu

    2016-02-01

    We add new modules for receiver function (RF) analysis in SplitLab toolbox, which includes the manual RF analysis module, automatic RF analysis and related quality control modules, and H- k stacking module. The updated toolbox (named SplitRFLab toolbox), especially its automatic RF analysis module, could calculate the RFs quickly and efficiently, which is very useful in RF analysis with huge amount of seismic data. China is now conducting the ChinArray project that plans to deploy thousands of portable stations across Chinese mainland. Our SplitRFLab toolbox may obtain reliable RF results quickly at the first time, which provide essentially new constraint to the crustal and mantle structures.

  2. Using Configural Frequency Analysis as a Person-Centered Analytic Approach with Categorical Data

    Science.gov (United States)

    Stemmler, Mark; Heine, Jörg-Henrik

    2017-01-01

    Configural frequency analysis and log-linear modeling are presented as person-centered analytic approaches for the analysis of categorical or categorized data in multi-way contingency tables. Person-centered developmental psychology, based on the holistic interactionistic perspective of the Stockholm working group around David Magnusson and Lars…

  3. Visual Analytics approach for Lightning data analysis and cell nowcasting

    Science.gov (United States)

    Peters, Stefan; Meng, Liqiu; Betz, Hans-Dieter

    2013-04-01

    Thunderstorms and their ground effects, such as flash floods, hail, lightning, strong wind and tornadoes, are responsible for most weather damages (Bonelli & Marcacci 2008). Thus to understand, identify, track and predict lightning cells is essential. An important aspect for decision makers is an appropriate visualization of weather analysis results including the representation of dynamic lightning cells. This work focuses on the visual analysis of lightning data and lightning cell nowcasting which aim to detect and understanding spatial-temporal patterns of moving thunderstorms. Lightnings are described by 3D coordinates and the exact occurrence time of lightnings. The three-dimensionally resolved total lightning data used in our experiment are provided by the European lightning detection network LINET (Betz et al. 2009). In all previous works, lightning point data, detected lightning cells and derived cell tracks are visualized in 2D. Lightning cells are either displayed as 2D convex hulls with or without the underlying lightning point data. Due to recent improvements of lightning data detection and accuracy, there is a growing demand on multidimensional and interactive visualization in particular for decision makers. In a first step lightning cells are identified and tracked. Then an interactive graphic user interface (GUI) is developed to investigate the dynamics of the lightning cells: e.g. changes of cell density, location, extension as well as merging and splitting behavior in 3D over time. In particular a space time cube approach is highlighted along with statistical analysis. Furthermore a lightning cell nowcasting is conducted and visualized. The idea thereby is to predict the following cell features for the next 10-60 minutes including location, centre, extension, density, area, volume, lifetime and cell feature probabilities. The main focus will be set to a suitable interactive visualization of the predicted featured within the GUI. The developed visual

  4. A conflict of analysis: analytical chemistry and milk adulteration in Victorian Britain.

    Science.gov (United States)

    Steere-Williams, Jacob

    2014-08-01

    This article centres on a particularly intense debate within British analytical chemistry in the late nineteenth century, between local public analysts and the government chemists of the Inland Revenue Service. The two groups differed in both practical methodologies and in the interpretation of analytical findings. The most striking debates in this period were related to milk analysis, highlighted especially in Victorian courtrooms. It was in protracted court cases, such as the well known Manchester Milk Case in 1883, that analytical chemistry was performed between local public analysts and the government chemists, who were often both used as expert witnesses. Victorian courtrooms were thus important sites in the context of the uneven professionalisation of chemistry. I use this tension to highlight what Christopher Hamlin has called the defining feature of Victorian public health, namely conflicts of professional jurisdiction, which adds nuance to histories of the struggle of professionalisation and public credibility in analytical chemistry.

  5. A technique for setting analytical thresholds in massively parallel sequencing-based forensic DNA analysis.

    Science.gov (United States)

    Young, Brian; King, Jonathan L; Budowle, Bruce; Armogida, Luigi

    2017-01-01

    Amplicon (targeted) sequencing by massively parallel sequencing (PCR-MPS) is a potential method for use in forensic DNA analyses. In this application, PCR-MPS may supplement or replace other instrumental analysis methods such as capillary electrophoresis and Sanger sequencing for STR and mitochondrial DNA typing, respectively. PCR-MPS also may enable the expansion of forensic DNA analysis methods to include new marker systems such as single nucleotide polymorphisms (SNPs) and insertion/deletions (indels) that currently are assayable using various instrumental analysis methods including microarray and quantitative PCR. Acceptance of PCR-MPS as a forensic method will depend in part upon developing protocols and criteria that define the limitations of a method, including a defensible analytical threshold or method detection limit. This paper describes an approach to establish objective analytical thresholds suitable for multiplexed PCR-MPS methods. A definition is proposed for PCR-MPS method background noise, and an analytical threshold based on background noise is described.

  6. Joint multifractal analysis based on the partition function approach: analytical analysis, numerical simulation and empirical application

    Science.gov (United States)

    Xie, Wen-Jie; Jiang, Zhi-Qiang; Gu, Gao-Feng; Xiong, Xiong; Zhou, Wei-Xing

    2015-10-01

    Many complex systems generate multifractal time series which are long-range cross-correlated. Numerous methods have been proposed to characterize the multifractal nature of these long-range cross correlations. However, several important issues about these methods are not well understood and most methods consider only one moment order. We study the joint multifractal analysis based on partition function with two moment orders, which was initially invented to investigate fluid fields, and derive analytically several important properties. We apply the method numerically to binomial measures with multifractal cross correlations and bivariate fractional Brownian motions without multifractal cross correlations. For binomial multifractal measures, the explicit expressions of mass function, singularity strength and multifractal spectrum of the cross correlations are derived, which agree excellently with the numerical results. We also apply the method to stock market indexes and unveil intriguing multifractality in the cross correlations of index volatilities.

  7. Meta-analysis as Statistical and Analytical Method of Journal’s Content Scientific Evaluation

    Science.gov (United States)

    Masic, Izet; Begic, Edin

    2015-01-01

    Introduction: A meta-analysis is a statistical and analytical method which combines and synthesizes different independent studies and integrates their results into one common result. Goal: Analysis of the journals “Medical Archives”, “Materia Socio Medica” and “Acta Informatica Medica”, which are located in the most eminent indexed databases of the biomedical milieu. Material and methods: The study has retrospective and descriptive character, and included the period of the calendar year 2014. Study included six editions of all three journals (total of 18 journals). Results: In this period was published a total of 291 articles (in the “Medical Archives” 110, “Materia Socio Medica” 97, and in “Acta Informatica Medica” 84). The largest number of articles was original articles. Small numbers have been published as professional, review articles and case reports. Clinical events were most common in the first two journals, while in the journal “Acta Informatica Medica” belonged to the field of medical informatics, as part of pre-clinical medical disciplines. Articles are usually required period of fifty to fifty nine days for review. Articles were received from four continents, mostly from Europe. The authors are most often from the territory of Bosnia and Herzegovina, then Iran, Kosovo and Macedonia. Conclusion: The number of articles published each year is increasing, with greater participation of authors from different continents and abroad. Clinical medical disciplines are the most common, with the broader spectrum of topics and with a growing number of original articles. Greater support of the wider scientific community is needed for further development of all three of the aforementioned journals. PMID:25870484

  8. An introduction to clinical microeconomic analysis: purposes and analytic methods.

    Science.gov (United States)

    Weintraub, W S; Mauldin, P D; Becker, E R

    1994-06-01

    The recent concern with health care economics has fostered the development of a new discipline that is generally called clinical microeconomics. This is a discipline in which microeconomic methods are used to study the economics of specific medical therapies. It is possible to perform stand alone cost analyses, but more profound insight into the medical decision making process may be accomplished by combining cost studies with measures of outcome. This is most often accomplished with cost-effectiveness or cost-utility studies. In cost-effectiveness studies there is one measure of outcome, often death. In cost-utility studies there are multiple measures of outcome, which must be grouped together to give an overall picture of outcome or utility. There are theoretical limitations to the determination of utility that must be accepted to perform this type of analysis. A summary statement of outcome is quality adjusted life years (QALYs), which is utility time socially discounted survival. Discounting is used because people value a year of future life less than a year of present life. Costs are made up of in-hospital direct, professional, follow-up direct, and follow-up indirect costs. Direct costs are for medical services. Indirect costs reflect opportunity costs such as lost time at work. Cost estimates are often based on marginal costs, or the cost for one additional procedure of the same type. Finally an overall statistic may be generated as cost per unit increase in effectiveness, such as dollars per QALY.(ABSTRACT TRUNCATED AT 250 WORDS)

  9. Local analytical sensitivity analysis for design of continua with optimized 3D buckling behavior

    DEFF Research Database (Denmark)

    Pedersen, Niels Leergaard; Pedersen, Pauli

    2018-01-01

    The localized analytical sensitivity for eigenfrequency is extended to the non-linear problem of 3D continuum buckling analysis. Implemented in a finite element approach the inherent complexity of mode switching and multiple eigenvalues is found not to be a practical problem. The number of necess......The localized analytical sensitivity for eigenfrequency is extended to the non-linear problem of 3D continuum buckling analysis. Implemented in a finite element approach the inherent complexity of mode switching and multiple eigenvalues is found not to be a practical problem. The number...

  10. Perioperative and ICU Healthcare Analytics within a Veterans Integrated System Network: a Qualitative Gap Analysis.

    Science.gov (United States)

    Mudumbai, Seshadri; Ayer, Ferenc; Stefanko, Jerry

    2017-08-01

    Health care facilities are implementing analytics platforms as a way to document quality of care. However, few gap analyses exist on platforms specifically designed for patients treated in the Operating Room, Post-Anesthesia Care Unit, and Intensive Care Unit (ICU). As part of a quality improvement effort, we undertook a gap analysis of an existing analytics platform within the Veterans Healthcare Administration. The objectives were to identify themes associated with 1) current clinical use cases and stakeholder needs; 2) information flow and pain points; and 3) recommendations for future analytics development. Methods consisted of semi-structured interviews in 2 phases with a diverse set (n = 9) of support personnel and end users from five facilities across a Veterans Integrated Service Network. Phase 1 identified underlying needs and previous experiences with the analytics platform across various roles and operational responsibilities. Phase 2 validated preliminary feedback, lessons learned, and recommendations for improvement. Emerging themes suggested that the existing system met a small pool of national reporting requirements. However, pain points were identified with accessing data in several information system silos and performing multiple manual validation steps of data content. Notable recommendations included enhancing systems integration to create "one-stop shopping" for data, and developing a capability to perform trends analysis. Our gap analysis suggests that analytics platforms designed for surgical and ICU patients should employ approaches similar to those being used for primary care patients.

  11. Waste Receiving and Processing (WRAP) Facility Final Safety Analysis Report (FSAR)

    Energy Technology Data Exchange (ETDEWEB)

    TOMASZEWSKI, T.A.

    2000-04-25

    The Waste Receiving and Processing Facility (WRAP), 2336W Building, on the Hanford Site is designed to receive, confirm, repackage, certify, treat, store, and ship contact-handled transuranic and low-level radioactive waste from past and present U.S. Department of Energy activities. The WRAP facility is comprised of three buildings: 2336W, the main processing facility (also referred to generically as WRAP); 2740W, an administrative support building; and 2620W, a maintenance support building. The support buildings are subject to the normal hazards associated with industrial buildings (no radiological materials are handled) and are not part of this analysis except as they are impacted by operations in the processing building, 2336W. WRAP is designed to provide safer, more efficient methods of handling the waste than currently exist on the Hanford Site and contributes to the achievement of as low as reasonably achievable goals for Hanford Site waste management.

  12. Waste Receiving and Processing (WRAP) Facility Final Safety Analysis Report (FSAR)

    International Nuclear Information System (INIS)

    TOMASZEWSKI, T.A.

    2000-01-01

    The Waste Receiving and Processing Facility (WRAP), 2336W Building, on the Hanford Site is designed to receive, confirm, repackage, certify, treat, store, and ship contact-handled transuranic and low-level radioactive waste from past and present U.S. Department of Energy activities. The WRAP facility is comprised of three buildings: 2336W, the main processing facility (also referred to generically as WRAP); 2740W, an administrative support building; and 2620W, a maintenance support building. The support buildings are subject to the normal hazards associated with industrial buildings (no radiological materials are handled) and are not part of this analysis except as they are impacted by operations in the processing building, 2336W. WRAP is designed to provide safer, more efficient methods of handling the waste than currently exist on the Hanford Site and contributes to the achievement of as low as reasonably achievable goals for Hanford Site waste management

  13. Framework for Analytic Cognition (FAC): A Guide for Doing All-Source Intelligence Analysis

    Science.gov (United States)

    2011-12-01

    situation. SWOT analysis helps strategists focus on the key issues that they must address in order to enhance an organization’s success. It is...within the event sequence.” 129 Sharma, A. " SWOT Analysis " in The Analyst’s Cookbook. Volume I...Structured Analytic Techniques for Improving Intelligence Analysis , 2009. Abelson, R.P. "Beliefs are Like Possessions," Journal for the Theory of

  14. Comparative analysis of methods for real-time analytical control of chemotherapies preparations.

    Science.gov (United States)

    Bazin, Christophe; Cassard, Bruno; Caudron, Eric; Prognon, Patrice; Havard, Laurent

    2015-10-15

    Control of chemotherapies preparations are now an obligation in France, though analytical control is compulsory. Several methods are available and none of them is presumed as ideal. We wanted to compare them so as to determine which one could be the best choice. We compared non analytical (visual and video-assisted, gravimetric) and analytical (HPLC/FIA, UV/FT-IR, UV/Raman, Raman) methods thanks to our experience and a SWOT analysis. The results of the analysis show great differences between the techniques, but as expected none us them is without defects. However they can probably be used in synergy. Overall for the pharmacist willing to get involved, the implementation of the control for chemotherapies preparations must be widely anticipated, with the listing of every parameter, and remains according to us an analyst's job. Copyright © 2015 Elsevier B.V. All rights reserved.

  15. Stability analysis of magnetized neutron stars - a semi-analytic approach

    Science.gov (United States)

    Herbrik, Marlene; Kokkotas, Kostas D.

    2017-04-01

    We implement a semi-analytic approach for stability analysis, addressing the ongoing uncertainty about stability and structure of neutron star magnetic fields. Applying the energy variational principle, a model system is displaced from its equilibrium state. The related energy density variation is set up analytically, whereas its volume integration is carried out numerically. This facilitates the consideration of more realistic neutron star characteristics within the model compared to analytical treatments. At the same time, our method retains the possibility to yield general information about neutron star magnetic field and composition structures that are likely to be stable. In contrast to numerical studies, classes of parametrized systems can be studied at once, finally constraining realistic configurations for interior neutron star magnetic fields. We apply the stability analysis scheme on polytropic and non-barotropic neutron stars with toroidal, poloidal and mixed fields testing their stability in a Newtonian framework. Furthermore, we provide the analytical scheme for dropping the Cowling approximation in an axisymmetric system and investigate its impact. Our results confirm the instability of simple magnetized neutron star models as well as a stabilization tendency in the case of mixed fields and stratification. These findings agree with analytical studies whose spectrum of model systems we extend by lifting former simplifications.

  16. Analytical standards production for the analysis of pomegranate anthocyanins by HPLC

    Directory of Open Access Journals (Sweden)

    Manuela Cristina Pessanha de Araújo Santiago

    2014-03-01

    Full Text Available Pomegranate (Punica granatum L. is a fruit with a long medicinal history, especially due to its phenolic compounds content, such as the anthocyanins, which are reported as one of the most important natural antioxidants. The analysis of the anthocyanins by high performance liquid chromatography (HPLC can be considered as an important tool to evaluate the quality of pomegranate juice. For research laboratories the major challenge in using HPLC for quantitative analyses is the acquisition of high purity analytical standards, since these are expensive and in some cases not even commercially available. The aim of this study was to obtain analytical standards for the qualitative and quantitative analysis of the anthocyanins from pomegranate. Five vegetable matrices (pomegranate flower, jambolan, jabuticaba, blackberry and strawberry fruits were used to isolate each of the six anthocyanins present in pomegranate fruit, using an analytical HPLC scale with non-destructive detection, it being possible to subsequently use them as analytical standards. Furthermore, their identities were confirmed by high resolution mass spectrometry. The proposed procedure showed that it is possible to obtain analytical standards of anthocyanins with a high purity grade (98.0 to 99.9% from natural sources, which was proved to be an economic strategy for the production of standards by laboratories according to their research requirements.

  17. Classification and recognition in artificial grammar learning: Analysis of receiver operating characteristics.

    Science.gov (United States)

    Lotz, Anja; Kinder, Annette

    2006-04-01

    In two experiments we investigated recognition and classification judgements using an artificial grammar learning paradigm. In Experiment 1, when only new test items had to be judged, analysis of z-transformed receiver operating characteristics (z-ROCs) revealed no differences between classification and recognition. In Experiment 2, where we included old test items, z-ROCs in the two tasks differed, suggesting that judgements relied on different types of information. The results are interpreted in terms of heuristics that people use when making classification and recognition judgements.

  18. Analysis of Multi-Antenna GNSS Receiver Performance under Jamming Attacks.

    Science.gov (United States)

    Vagle, Niranjana; Broumandan, Ali; Lachapelle, Gérard

    2016-11-17

    Although antenna array-based Global Navigation Satellite System (GNSS) receivers can be used to mitigate both narrowband and wideband electronic interference sources, measurement distortions induced by array processing methods are not suitable for high precision applications. The measurement distortions have an adverse effect on the carrier phase ambiguity resolution, affecting the navigation solution. Depending on the array attitude information availability and calibration parameters, different spatial processing methods can be implemented although they distort carrier phase measurements in some cases. This paper provides a detailed investigation of the effect of different array processing techniques on array-based GNSS receiver measurements and navigation performance. The main novelty of the paper is to provide a thorough analysis of array-based GNSS receivers employing different beamforming techniques from tracking to navigation solution. Two beamforming techniques, namely Power Minimization (PM) and Minimum Power Distortionless Response (MPDR), are being investigated. In the tracking domain, the carrier Doppler, Phase Lock Indicator (PLI), and Carrier-to-Noise Ratio (C/N₀) are analyzed. Pseudorange and carrier phase measurement distortions and carrier phase position performance are also evaluated. Performance analyses results from simulated GNSS signals and field tests are provided.

  19. Investigation of drug products received for analysis in the Swedish STRIDA project on new psychoactive substances.

    Science.gov (United States)

    Bäckberg, Matilda; Jönsson, Karl-Henrik; Beck, Olof; Helander, Anders

    2018-02-01

    The web-based open sale of unregulated new psychoactive substances (NPS) has shown a steady increase in recent years. Analysis of drug products sold as NPS is useful to confirm the true chemical contents, for comparison with the substances detected in corresponding body fluids, but also to study drug trends. This work describes the examination of 251 drug products that were randomly submitted for analysis in 173 cases of suspected NPS-related intoxications in the Swedish STRIDA project in 2010-2015. Of the products, 39% were powders/crystals, 32% tablets/capsules, 16% herbal materials, 8% liquids, 1% blotters, and 4% others. The analysis involved tandem mass spectrometry and nuclear magnetic resonance spectroscopy. In 88 products (35%), classic psychoactive substances, prescription pharmaceuticals, dietary supplements, or doping agents were found; however, in none of these cases had an NPS-related intoxication been indicated from product markings or patient self-reports. Another 12 products tested negative for psychoactive substances. The remaining 151 products contained 86 different NPS (30% contained ≥2 substances). In 104 drug products, a specific NPS ingredient was indicated based on labelling (69%) or patient self-report; in 92 cases this was also analytically confirmed to be correct. Overall, the NPS products submitted for analysis in the STRIDA project showed a high degree of consistency between suspected and actual content (88%). The results of related urine and/or blood analysis further demonstrated that the patients commonly (89%) tested positive for the indicated NPS, but also revealed that polysubstance intoxication was common (83%), indicating use of additional drug products. Copyright © 2017 John Wiley & Sons, Ltd.

  20. Multicriteria decision analysis in ranking of analytical procedures for aldrin determination in water.

    Science.gov (United States)

    Tobiszewski, Marek; Orłowski, Aleksander

    2015-03-27

    The study presents the possibility of multi-criteria decision analysis (MCDA) application when choosing analytical procedures with low environmental impact. A type of MCDA, Preference Ranking Organization Method for Enrichment Evaluations (PROMETHEE), was chosen as versatile tool that meets all the analytical chemists--decision makers requirements. Twenty five analytical procedures for aldrin determination in water samples (as an example) were selected as input alternatives to MCDA analysis. Nine different criteria describing the alternatives were chosen from different groups--metrological, economical and the most importantly--environmental impact. The weights for each criterion were obtained from questionnaires that were sent to experts, giving three different scenarios for MCDA results. The results of analysis show that PROMETHEE is very promising tool to choose the analytical procedure with respect to its greenness. The rankings for all three scenarios placed solid phase microextraction and liquid phase microextraction--based procedures high, while liquid-liquid extraction, solid phase extraction and stir bar sorptive extraction--based procedures were placed low in the ranking. The results show that although some of the experts do not intentionally choose green analytical chemistry procedures, their MCDA choice is in accordance with green chemistry principles. The PROMETHEE ranking results were compared with more widely accepted green analytical chemistry tools--NEMI and Eco-Scale. As PROMETHEE involved more different factors than NEMI, the assessment results were only weakly correlated. Oppositely, the results of Eco-Scale assessment were well-correlated as both methodologies involved similar criteria of assessment. Copyright © 2015 Elsevier B.V. All rights reserved.

  1. Analytical importance of determination of lipase activity for the express analysis of contamination by heavy metals of sunflower seeds

    Directory of Open Access Journals (Sweden)

    Y. A. Dyachenko

    2016-01-01

    Full Text Available During the last decades becoming more sharply there is a problem of chemical and environmental monitoring and industrial inspection the content of toxic elements in food raw materials and foodstuff. At the same time there is a need to develop rapid methods, informative, integral, reflecting not only the safety but also the ecological purity of food raw materials. The method of determination of content of toxic elements on activity of its own lipase of in situ (AОL-method in seeds of oil-bearing crops, on the example of sunflower is offered. The system of mathematical assessment of analytical criteria of laboratory test used in clinical laboratory diagnostics was for this purpose adapted. Sunflower seeds in which established the maintenance of toxiferous elements served as an object of a research: Cd, Pb, As, Hg, by atomic absorption method on the KVANT-Z.ETA device. Further tests divided on clear, including high-quality and pollution-free, and polluted - naturally containing toxiferous elements and which are artificially contaminated. Definition of activity of a lipase of seeds was carried out by the standard titrimetric method. Decrease of the activity of enzyme was connected with the maintenance of toxiferous elements. Proceeding from the received results counted an analytical significance (sensitivity, specificity, and predictive value of descriptiveness the positive and negative results of determination of level of maintenance of toxiferous elements in sunflower seeds by the AОL-method. The set values of analytical specificity of a method and predictive value of a positive take at the level of 77.3% and 71.4% respectively, do not allow to use the offered method for the quantitative analysis, however, analytical sensitivity at the level of 86.2% and the predictive value of the negative result at the level of 89.5%, allow to recommend the AOL-method for screening programs of chemical environmental monitoring and technological monitoring of a

  2. Whole brain magnetization transfer histogram analysis of pediatric acute lymphoblastic leukemia patients receiving intrathecal methotrexate therapy

    International Nuclear Information System (INIS)

    Yamamoto, Akira; Miki, Yukio; Adachi, Souichi

    2006-01-01

    Background and purpose: The purpose of this prospective study was to evaluate the hypothesis that magnetization transfer ratio (MTR) histogram analysis of the whole brain could detect early and subtle brain changes nonapparent on conventional magnetic resonance imaging (MRI) in children with acute lymphoblastic leukemia (ALL) receiving methotrexate (MTX) therapy. Materials and methods: Subjects in this prospective study comprised 10 children with ALL (mean age, 6 years; range, 0-16 years). In addition to conventional MRI, magnetization transfer images were obtained before and after intrathecal and intravenous MTX therapy. MTR values were calculated and plotted as a histogram, and peak height and location were calculated. Differences in peak height and location between pre- and post-MTX therapy scans were statistically analyzed. Conventional MRI was evaluated for abnormal signal area in white matter. Results: MTR peak height was significantly lower on post-MTX therapy scans than on pre-MTX therapy scans (p = 0.002). No significant differences in peak location were identified between pre- and post-chemotherapy imaging. No abnormal signals were noted in white matter on either pre- or post-MTX therapy conventional MRI. Conclusions: This study demonstrates that MTR histogram analysis allows better detection of early and subtle brain changes in ALL patients who receive MTX therapy than conventional MRI

  3. Whole brain magnetization transfer histogram analysis of pediatric acute lymphoblastic leukemia patients receiving intrathecal methotrexate therapy

    Energy Technology Data Exchange (ETDEWEB)

    Yamamoto, Akira [Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto-shi Kyoto 606-8507 (Japan)]. E-mail: yakira@kuhp.kyoto-u.ac.jp; Miki, Yukio [Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto-shi Kyoto 606-8507 (Japan)]. E-mail: mikiy@kuhp.kyoto-u.ac.jp; Adachi, Souichi [Department of Pediatrics, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto-shi Kyoto 606-8507 (Japan)]. E-mail: sadachi@kuhp.kyoto-u.ac.jp (and others)

    2006-03-15

    Background and purpose: The purpose of this prospective study was to evaluate the hypothesis that magnetization transfer ratio (MTR) histogram analysis of the whole brain could detect early and subtle brain changes nonapparent on conventional magnetic resonance imaging (MRI) in children with acute lymphoblastic leukemia (ALL) receiving methotrexate (MTX) therapy. Materials and methods: Subjects in this prospective study comprised 10 children with ALL (mean age, 6 years; range, 0-16 years). In addition to conventional MRI, magnetization transfer images were obtained before and after intrathecal and intravenous MTX therapy. MTR values were calculated and plotted as a histogram, and peak height and location were calculated. Differences in peak height and location between pre- and post-MTX therapy scans were statistically analyzed. Conventional MRI was evaluated for abnormal signal area in white matter. Results: MTR peak height was significantly lower on post-MTX therapy scans than on pre-MTX therapy scans (p = 0.002). No significant differences in peak location were identified between pre- and post-chemotherapy imaging. No abnormal signals were noted in white matter on either pre- or post-MTX therapy conventional MRI. Conclusions: This study demonstrates that MTR histogram analysis allows better detection of early and subtle brain changes in ALL patients who receive MTX therapy than conventional MRI.

  4. Stress analysis of shielded receiver lifting frame for core sampler truck {number_sign}2

    Energy Technology Data Exchange (ETDEWEB)

    Ziada, H.H.

    1994-11-04

    This analysis evaluates the structural design adequacy of the shielded receiver lifting frame (SRLF) for the rotary mode core sampler truck number 2 (RMCST{number_sign}2). The analysis considers the loads expected during operation of the SRLF. Most of the existing welds were not in conformance with those specified on the drawings, H-2-91715 and -91716 (RHO 1988a and RHO 1988b). Stress analysts and engineers examined the configuration of the welds connecting the frame members of the SRLF and those connecting the SRLF to the drill rig. In comparison to those shown on the drawing, some of the actual welds appear stronger and others undersized. For example, the actual fillet welds completely encircle the junctures of members, although the drawings show some welds to be on two sides only. Attempts to find the original design calculations were unsuccessful. To resolve the nonconformance, the critical welds were identified by analysis and subsequently inspected to ensure they are as large or larger than the minimum is defined by weld leg size. A required weld size, as determined by stress analysis, of 0.1 inch or larger is considered to be critical. This size was selected because no existing welds were found to be less than 0.125 inch. Analysis results led to weld modifications to strengthen the SRLF. The weld modifications performed are described in WHC 1994.

  5. Stress analysis of shielded receiver lifting frame for core sampler truck number-sign 2

    International Nuclear Information System (INIS)

    Ziada, H.H.

    1994-01-01

    This analysis evaluates the structural design adequacy of the shielded receiver lifting frame (SRLF) for the rotary mode core sampler truck number 2 (RMCST number-sign 2). The analysis considers the loads expected during operation of the SRLF. Most of the existing welds were not in conformance with those specified on the drawings, H-2-91715 and -91716 (RHO 1988a and RHO 1988b). Stress analysts and engineers examined the configuration of the welds connecting the frame members of the SRLF and those connecting the SRLF to the drill rig. In comparison to those shown on the drawing, some of the actual welds appear stronger and others undersized. For example, the actual fillet welds completely encircle the junctures of members, although the drawings show some welds to be on two sides only. Attempts to find the original design calculations were unsuccessful. To resolve the nonconformance, the critical welds were identified by analysis and subsequently inspected to ensure they are as large or larger than the minimum is defined by weld leg size. A required weld size, as determined by stress analysis, of 0.1 inch or larger is considered to be critical. This size was selected because no existing welds were found to be less than 0.125 inch. Analysis results led to weld modifications to strengthen the SRLF. The weld modifications performed are described in WHC 1994

  6. ENVIRONMENTAL ANALYTICAL CHEMISTRY OF ...

    Science.gov (United States)

    Within the scope of a number of emerging contaminant issues in environmental analysis, one area that has received a great deal of public interest has been the assessment of the role of pharmaceuticals and personal care products (PPCPs) as stressors and agents of change in ecosystems as well as their role in unplanned human exposure. The relationship between personal actions and the occurrence of PPCPs in the environment is clear-cut and comprehensible to the public. In this overview, we attempt to examine the separations aspect of the analytical approach to the vast array of potential analytes among this class of compounds. We also highlight the relationship between these compounds and endocrine disrupting compounds (EDCs) and between PPCPs and EDCs and the more traditional environmental analytes such as the persistent organic pollutants (POPs). Although the spectrum of chemical behavior extends from hydrophobic to hydrophilic, the current focus has shifted to moderately and highly polar analytes. Thus, emphasis on HPLC and LC/MS has grown and MS/MS has become a detection technique of choice with either electrospray ionization or atmospheric pressure chemical ionization. This contrasts markedly with the bench mark approach of capillary GC, GC/MS and electron ionization in traditional environmental analysis. The expansion of the analyte list has fostered new vigor in the development of environmental analytical chemistry, modernized the range of tools appli

  7. Next generation GNSS single receiver cycle slip reliability

    NARCIS (Netherlands)

    Teunissen, P.J.G.; De Bakker, P.F.

    2009-01-01

    In this contribution we study the multi-frequency, carrier-phase slip detection capabilities of a single receiver. Our analysis is based on an analytical expression that we present for themulti-frequencyminimal detectable carrier phase cycle slip.

  8. A semi-analytical decomposition analysis of surface plasmon generation and the optimal nanoledge plasmonic device.

    Science.gov (United States)

    Zeng, Zheng; Mendis, Madu N; Waldeck, David H; Wei, Jianjun

    Surface plasmon resonance (SPR) of nanostructured thin metal films (so-called nanoplasmonics) has attracted intense attention due to its versatility for optical sensing and chip-based device integration. Understanding the underlying physics and developing applications of nanoplasmonic devices with desirable optical properties, e.g. intensity of light scattering and high refractive index (RI) sensitivity at the perforated metal film, is crucial for practical uses in physics, biomedical detection, and environmental monitoring. This work presents a semi-analytical model that enables decomposition and quantitative analysis of surface plasmon generation at a new complex nanoledge aperture structure under plane-wave illumination, thus providing insight on how to optimize plasmonic devices for optimal plasmonic generation efficiencies and RI sensitivity. A factor analysis of parameters (geometric, dielectric-RI, and incident wavelength) relevant to surface plasmon generation is quantitatively investigated to predict the surface plasmon polariton (SPP) generation efficiency. In concert with the analytical treatment, a finite-difference time-domain (FDTD) simulation is used to model the optical transmission spectra and RI sensitivity as a function of the nanoledge device's geometric parameters, and it shows good agreement with the analytical model. Further validation of the analytical approach is provided by fabricating subwavelength nanoledge devices and testing their optical transmission and RI sensitivity.

  9. Mantle upwelling beneath Madagascar: evidence from receiver function analysis and shear wave splitting

    Science.gov (United States)

    Paul, Jonathan D.; Eakin, Caroline M.

    2017-07-01

    Crustal receiver functions have been calculated from 128 events for two three-component broadband seismomenters located on the south coast (FOMA) and in the central High Plateaux (ABPO) of Madagascar. For each station, crustal thickness and V p / V s ratio were estimated from H- κ plots. Self-consistent receiver functions from a smaller back-azimuthal range were then selected, stacked and inverted to determine shear wave velocity structure as a function of depth. These results were corroborated by guided forward modeling and by Monte Carlo error analysis. The crust is found to be thinner (39 ± 0.7 km) beneath the highland center of Madagascar compared to the coast (44 ± 1.6 km), which is the opposite of what would be expected for crustal isostasy, suggesting that present-day long wavelength topography is maintained, at least in part, dynamically. This inference of dynamic support is corroborated by shear wave splitting analyses at the same stations, which produce an overwhelming majority of null results (>96 %), as expected for vertical mantle flow or asthenospheric upwelling beneath the island. These findings suggest a sub-plate origin for dynamic support.

  10. The Field of Eyewitness Memory Should Abandon Probative Value and Embrace Receiver Operating Characteristic Analysis.

    Science.gov (United States)

    Wixted, John T; Mickes, Laura

    2012-05-01

    Clark (2012) highlights an important issue that has received inadequate attention in the eyewitness memory literature: lineup procedures that reduce the false identification rate (a desirable effect) often tend to reduce the correct identification rate as well (an undesirable effect). Determining which procedure is diagnostically superior under those conditions is not easy. Clark (2012) showed that the procedure with the lower false identification rate could be associated with higher overall costs to society once costs and benefits are both taken into consideration. Beyond the issue of cost, we argue that Clark's (2012) observation has far reaching implications for evaluating the diagnostic performance of a lineup procedure. Specifically, the field of eyewitness memory has attempted to differentiate between lineup procedures by using various measures of probative value (such as the diagnosticity ratio). However, contrary to intuition, probative value is not a relevant consideration. Instead, lineup procedures should be compared using receiver operating characteristic analysis, as is routinely done in other applied fields (such as radiology). © The Author(s) 2012.

  11. Combined teleseismic surface wave and receiver function analysis of the crust and upper mantle of Madagascar

    Science.gov (United States)

    Pratt, M. J.; Aleqabi, G. I.; Wysession, M. E.; Wiens, D. A.; Nyblade, A.; Shore, P.; Rambolamanana, G.; Tsiriandrimanana, R.; Andriampenomanana Ny Ony, F. S. T.

    2014-12-01

    The continental crust and upper mantle velocity structure beneath Madagascar remained poorly constrained until recent deployments of broadband seismic instrumentation across the island. The MACOMO (MAdagascar, COmoros and MOzambique), RHUM-RUM (Réunion Hotspot and Upper Mantle - Réunions Unterer Mantel) and the Madagascar Seismic Profile experiments have opened up this region to be studied in detail for the first time. The island is an amalgamation of an Archean craton, associated with the Western Dhawar craton of southern India, and a series of Proterozoic terranes that comprise the backbone of the island (Tucker et al., 2010). A receiver-function analysis has provided both the first Moho depth measurements and spatially discrete 1-D shear velocity results that matched well with known tectonic regions. To provide a more continuous 2-D and 3-D velocity structure map, teleseismic surface wave analysis is employed. Using Helmholtz tomography as implemented by the ASWMS package (Ge, Gaherty and Hutko; 2014), we are able to map phase velocities from the cross-correlation of station pairs at periods 20-100 s. At periods 20-40 s our results compare well with ambient noise analysis results (see poster by Wysession et al. (this meeting)). The prominent features of these results are a distinct low phase-velocity sector beneath the central Itasy region, with a secondary low phase-velocity region to the north of the island. Both the central part of the island and the northern region have experienced geothermal activity in recent times as well as volcanic activity within the last 10,000 years. This may suggest that the crust and underlying mantle in these regions remains at relatively higher temperatures than the surrounding rock. Combining this information with receiver-function analysis, we jointly invert our data for the shear velocity structure. These analyses will constrain the upper mantle seismic velocities in the region, allowing further analysis from body waves to

  12. [Comparative analysis of the neurological status in patients with lumbar discopathy receiving conservative or operative therapies].

    Science.gov (United States)

    Radziszewski, Krzysztof Roch

    2007-03-01

    Neurological examination is one of basic assessment methods of the patients with discopathy of the lumbar spine. Neurological status of the patients can significantly change depending on progression of the disease of the intervertebral disc. It often determines a selection of the treatment method; it is also important criterion for assessment of efficacy of the accepted procedure. The aim of this study was to retrospectively evaluate neurological status in the patients with lumbar discopathy receiving only conservative therapy as well as undergoing surgical procedures. 665 patients aged between 16 and 76 years with discopathy at L4-L5 and L5-S1 levels have been enrolled to the study. In estimated group 348 patients received only a conservative therapy whereas 317 patients undergone an operative procedure. Study included hospitalization period and more than ten year period after discharge from the Clinic. Collected material has been analyzed in tree age groups: young persons (up to 30), mid age persons (31-50 years) and older persons (at the age of above 50). Neurological examination included analysis of the following parameters: cough symptom, Laségue's sign, stretch reflexes (patellar, ankle), superficial perception and vibration, function of sphincters, muscular power). No significant progression of the neurological symptoms up to the fifth year of treatment has been seen in group of patients receiving conservative therapy. In group of operated patients starting the second year after surgical procedure, number of diagnosed pathological neurological symptoms systematically was increasing. Patients at the age above 50 presented significantly higher level of neurological disturbances than young and patients in mid age. In the baseline study, level of diagnosed neurological disturbances in group of patients referred to surgical procedure was significantly higher than in group of patients receiving only conservative therapy. Conservative treatment and operative

  13. Receiving Basin for Offsite Fuels and the Resin Regeneration Facility Safety Analysis Report, Executive Summary

    International Nuclear Information System (INIS)

    Shedrow, C.B.

    1999-01-01

    The Safety Analysis Report documents the safety authorization basis for the Receiving Basin for Offsite Fuels (RBOF) and the Resin Regeneration Facility (RRF) at the Savannah River Site (SRS). The present mission of the RBOF and RRF is to continue in providing a facility for the safe receipt, storage, handling, and shipping of spent nuclear fuel assemblies from power and research reactors in the United States, fuel from SRS and other Department of Energy (DOE) reactors, and foreign research reactors fuel, in support of the nonproliferation policy. The RBOF and RRF provide the capability to handle, separate, and transfer wastes generated from nuclear fuel element storage. The DOE and Westinghouse Savannah River Company, the prime operating contractor, are committed to managing these activities in such a manner that the health and safety of the offsite general public, the site worker, the facility worker, and the environment are protected

  14. Receiving Basin for Offsite Fuels and the Resin Regeneration Facility Safety Analysis Report, Executive Summary

    Energy Technology Data Exchange (ETDEWEB)

    Shedrow, C.B.

    1999-11-29

    The Safety Analysis Report documents the safety authorization basis for the Receiving Basin for Offsite Fuels (RBOF) and the Resin Regeneration Facility (RRF) at the Savannah River Site (SRS). The present mission of the RBOF and RRF is to continue in providing a facility for the safe receipt, storage, handling, and shipping of spent nuclear fuel assemblies from power and research reactors in the United States, fuel from SRS and other Department of Energy (DOE) reactors, and foreign research reactors fuel, in support of the nonproliferation policy. The RBOF and RRF provide the capability to handle, separate, and transfer wastes generated from nuclear fuel element storage. The DOE and Westinghouse Savannah River Company, the prime operating contractor, are committed to managing these activities in such a manner that the health and safety of the offsite general public, the site worker, the facility worker, and the environment are protected.

  15. Protector Receiver Principle: For a Justification of Archievement in the Light of the Legislated Behavioral Analysis

    Directory of Open Access Journals (Sweden)

    Raissa Pimentel Silva

    2015-12-01

    Full Text Available This trial was designed with the aim of justifying the need for improvement and effective implementation of standards directly related to the promotional role of environmental law, especially the new principle of the protector-receiver, based on the understanding that the classic normative model of command and control does not come out to be enough to achieve the desired behavioral targeting of legislated, especially when considering a scenario where the weaknesses that underlie the exercise of power of the state police, especially the acts of enforcement, are latent. To set up the explanation, will be presented, from an economic and behavioral analysis, the social stereotypes sustained by Oliver Wendell Holmes in the work The Path of the Law, consigning the characterization of the good man and bad man profiles, the latter considered by Jack Balkin a special version of homo economicus, interested in maximizing their personal satisfactions. Seated the premise that individuals, in general, adopts actions aimed at achieving a self-interest, will be presented, on the second part, the analysis of the mission and functions of the legal rules. To say that the law plays the primary role of regulation of social behavior and, therefore, should consider, harmonic mode, negative-repressive instruments and positive encourager ones, will be adopted, as pillars, lessons of Norberto Bobbio, drawn from his work General Theory of Law and From the function structure: further study of legal theory. Finally, by way of illustrating the reason behind the principle of protector - receiver, State Law No. 13.223 / 2015 establishing the State Policy on Payments by the State of Bahia Environmental Services will be presented.

  16. A MODEL OF ANALYSIS IN ANALYTICAL METHODOLOGY FOR BIOPHARMACEUTICAL QUALITY CONTROL.

    Science.gov (United States)

    Andrade, Cleyton; de la O Herrera, Miguel; Lemes, Elezer

    2018-02-14

    One key quality control parameter for biopharmaceutical products is the analysis of residual cellular DNA (rcDNA). To determine small amounts of DNA (around 100pg) that may be in a biologically-derived drug substance, an analytical method should be sensitive, robust, reliable and accurate. In principle, three techniques have the ability to measure rcDNA: radioactive dot-blot a type of Hybridization; Threshold and quantitative Polymerase Chain Reaction (qPCR). Quality Risk Management (QRM) is a systematic process for evaluating, controlling and reporting of risks which may affects method capabilities and supports a scientific and practical approach to decision making. This paper evaluates by QRM, an alternative approach to assessing the performance risks associated with quality control methods used with biopharmaceuticals, using the tool Hazard Analysis and Critical Control Points (HACCP). HACCP provides the possibility to find the steps in an analytical procedure with higher impact on method performance. By applying these principles to DNA analysis methods, we concluded that the radioactive dot-blot assay has the largest number of critical control points (CCP), followed by qPCR and Threshold. From the analysis of hazards (i.e. points of method failure) and the associated method procedure CCP, we concluded that the analytical methodology with the lowest risk for performance failure for rcDNA testing is the qPCR. Copyright © 2018, Parenteral Drug Association.

  17. Application of quantum dots as analytical tools in automated chemical analysis: A review

    International Nuclear Information System (INIS)

    Frigerio, Christian; Ribeiro, David S.M.; Rodrigues, S. Sofia M.; Abreu, Vera L.R.G.; Barbosa, João A.C.; Prior, João A.V.; Marques, Karine L.; Santos, João L.M.

    2012-01-01

    Highlights: ► Review on quantum dots application in automated chemical analysis. ► Automation by using flow-based techniques. ► Quantum dots in liquid chromatography and capillary electrophoresis. ► Detection by fluorescence and chemiluminescence. ► Electrochemiluminescence and radical generation. - Abstract: Colloidal semiconductor nanocrystals or quantum dots (QDs) are one of the most relevant developments in the fast-growing world of nanotechnology. Initially proposed as luminescent biological labels, they are finding new important fields of application in analytical chemistry, where their photoluminescent properties have been exploited in environmental monitoring, pharmaceutical and clinical analysis and food quality control. Despite the enormous variety of applications that have been developed, the automation of QDs-based analytical methodologies by resorting to automation tools such as continuous flow analysis and related techniques, which would allow to take advantage of particular features of the nanocrystals such as the versatile surface chemistry and ligand binding ability, the aptitude to generate reactive species, the possibility of encapsulation in different materials while retaining native luminescence providing the means for the implementation of renewable chemosensors or even the utilisation of more drastic and even stability impairing reaction conditions, is hitherto very limited. In this review, we provide insights into the analytical potential of quantum dots focusing on prospects of their utilisation in automated flow-based and flow-related approaches and the future outlook of QDs applications in chemical analysis.

  18. Fault feature analysis of cracked gear based on LOD and analytical-FE method

    Science.gov (United States)

    Wu, Jiateng; Yang, Yu; Yang, Xingkai; Cheng, Junsheng

    2018-01-01

    At present, there are two main ideas for gear fault diagnosis. One is the model-based gear dynamic analysis; the other is signal-based gear vibration diagnosis. In this paper, a method for fault feature analysis of gear crack is presented, which combines the advantages of dynamic modeling and signal processing. Firstly, a new time-frequency analysis method called local oscillatory-characteristic decomposition (LOD) is proposed, which has the attractive feature of extracting fault characteristic efficiently and accurately. Secondly, an analytical-finite element (analytical-FE) method which is called assist-stress intensity factor (assist-SIF) gear contact model, is put forward to calculate the time-varying mesh stiffness (TVMS) under different crack states. Based on the dynamic model of the gear system with 6 degrees of freedom, the dynamic simulation response was obtained for different tooth crack depths. For the dynamic model, the corresponding relation between the characteristic parameters and the degree of the tooth crack is established under a specific condition. On the basis of the methods mentioned above, a novel gear tooth root crack diagnosis method which combines the LOD with the analytical-FE is proposed. Furthermore, empirical mode decomposition (EMD) and ensemble empirical mode decomposition (EEMD) are contrasted with the LOD by gear crack fault vibration signals. The analysis results indicate that the proposed method performs effectively and feasibility for the tooth crack stiffness calculation and the gear tooth crack fault diagnosis.

  19. Performance and Integrity Analysis of the Vector Tracking Architecture of GNSS Receivers

    Science.gov (United States)

    Bhattacharyya, Susmita

    Frequent loss or attenuation of signals in urban areas and integrity (or reliability of system performance) are two principal challenges facing the Global Navigation Satellite Systems or GNSS today. They are of critical importance especially to safety or liability-critical applications where system malfunction can cause safety problems or has legal/economic consequences. To deal with the problem of integrity, algorithms called integrity monitors have been developed and fielded. These monitors are designed to raise an alarm when situations resulting in misleading information are identified. However, they do not enhance the ability of a GNSS receiver to track weak signals. Among several approaches proposed to deal with the problem of frequent signal outage, an advanced GNSS receiver architecture called vector tracking loops has attracted much attention in recent years. While there is an extensive body of knowledge that documents vector tracking's superiority to deal with weak signals, prior work on vector loop integrity monitoring is scant. Systematic designs of a vector loop-integrity monitoring scheme can find use in above-mentioned applications that are inherently vulnerable to frequent signal loss or attenuation. Developing such a system, however, warrants a thorough understanding of the workings of the vector architecture as the open literature provides very few preliminary studies in this regard. To this end, the first aspect of this research thoroughly explains the internal operations of the vector architecture. It recasts the existing complex vector architecture equations into parametric models that are mathematically tractable. An in-depth theoretical analysis of these models reveals that inter-satellite aiding is the key to vector tracking's superiority. The second aspect of this research performs integrity studies of the vector loops. Simulation results from the previous analysis show that inter-satellite aiding allows easy propagation of errors (and

  20. Evidential analytic hierarchy process dependence assessment methodology in human reliability analysis

    International Nuclear Information System (INIS)

    Chen, Lu Yuan; Zhou, Xinyi; Xiao, Fuyuan; Deng, Yong; Mahadevan, Sankaran

    2017-01-01

    In human reliability analysis, dependence assessment is an important issue in risky large complex systems, such as operation of a nuclear power plant. Many existing methods depend on an expert's judgment, which contributes to the subjectivity and restrictions of results. Recently, a computational method, based on the Dempster-Shafer evidence theory and analytic hierarchy process, has been proposed to handle the dependence in human reliability analysis. The model can deal with uncertainty in an analyst's judgment and reduce the subjectivity in the evaluation process. However, the computation is heavy and complicated to some degree. The most important issue is that the existing method is in a positive aspect, which may cause an underestimation of the risk. In this study, a new evidential analytic hierarchy process dependence assessment methodology, based on the improvement of existing methods, has been proposed, which is expected to be easier and more effective

  1. Text Stream Trend Analysis using Multiscale Visual Analytics with Applications to Social Media Systems

    Energy Technology Data Exchange (ETDEWEB)

    Steed, Chad A [ORNL; Beaver, Justin M [ORNL; BogenII, Paul L. [Google Inc.; Drouhard, Margaret MEG G [ORNL; Pyle, Joshua M [ORNL

    2015-01-01

    In this paper, we introduce a new visual analytics system, called Matisse, that allows exploration of global trends in textual information streams with specific application to social media platforms. Despite the potential for real-time situational awareness using these services, interactive analysis of such semi-structured textual information is a challenge due to the high-throughput and high-velocity properties. Matisse addresses these challenges through the following contributions: (1) robust stream data management, (2) automated sen- timent/emotion analytics, (3) inferential temporal, geospatial, and term-frequency visualizations, and (4) a flexible drill-down interaction scheme that progresses from macroscale to microscale views. In addition to describing these contributions, our work-in-progress paper concludes with a practical case study focused on the analysis of Twitter 1% sample stream information captured during the week of the Boston Marathon bombings.

  2. Coupled Analytical-Finite Element Methods for Linear Electromagnetic Actuator Analysis

    Directory of Open Access Journals (Sweden)

    K. Srairi

    2005-09-01

    Full Text Available In this paper, a linear electromagnetic actuator with moving parts is analyzed. The movement is considered through the modification of boundary conditions only using coupled analytical and finite element analysis. In order to evaluate the dynamic performance of the device, the coupling between electric, magnetic and mechanical phenomena is established. The displacement of the moving parts and the inductor current are determined when the device is supplied by capacitor discharge voltage.

  3. Element for Beam Dynamic Analysis Based on Analytical Deflection Trial Function

    Directory of Open Access Journals (Sweden)

    Qiongqiong Cao

    2015-01-01

    Full Text Available For beam dynamic finite element analysis, according to differential equation of motion of beam with distributed mass, general analytical solution of displacement equation for the beam vibration is obtained. By applying displacement element construction principle, the general solution of displacement equation is conversed to the mode expressed by beam end displacements. And taking the mode as displacement trial function, element stiffness matrix and element mass matrix for beam flexural vibration and axial vibration are established, respectively, by applying principle of minimum potential energy. After accurate integral, explicit form of element matrix is obtained. The comparison results show that the series of relative error between the solution of analytical trial function element and theoretical solution is about 1×10-9 and the accuracy and efficiency are superior to that of interpolation trial function element. The reason is that interpolation trial function cannot accurately simulate the displacement mode of vibrating beam. The accuracy of dynamic stiffness matrix method is almost identical with that of analytical trial function. But the application of dynamic stiffness matrix method in engineering is limited. The beam dynamic element obtained in this paper is analytical and accurate and can be applied in practice.

  4. The analytical and numerical approaches to the theory of the Moon's librations: Modern analysis and results

    Science.gov (United States)

    Petrova, N.; Zagidullin, A.; Nefedyev, Y.; Kosulin, V.; Andreev, A.

    2017-11-01

    Observing physical librations of celestial bodies and the Moon represents one of the astronomical methods of remotely assessing the internal structure of a celestial body without conducting expensive space experiments. The paper contains a review of recent advances in studying the Moon's structure using various methods of obtaining and applying the lunar physical librations (LPhL) data. In this article LPhL simulation methods of assessing viscoelastic and dissipative properties of the lunar body and lunar core parameters, whose existence has been recently confirmed during the seismic data reprocessing of ;Apollo; space mission, are described. Much attention is paid to physical interpretation of the free librations phenomenon and the methods for its determination. In the paper the practical application of the most accurate analytical LPhL tables (Rambaux and Williams, 2011) is discussed. The tables were built on the basis of complex analytical processing of the residual differences obtained when comparing long-term series of laser observations with the numerical ephemeris DE421. In the paper an efficiency analysis of two approaches to LPhL theory is conducted: the numerical and the analytical ones. It has been shown that in lunar investigation both approaches complement each other in various aspects: the numerical approach provides high accuracy of the theory, which is required for the proper processing of modern observations, the analytical approach allows to comprehend the essence of the phenomena in the lunar rotation, predict and interpret new effects in the observations of lunar body and lunar core parameters.

  5. Determination of detonation products equation of state from cylinder test: Analytical model and numerical analysis

    Directory of Open Access Journals (Sweden)

    Elek Predrag M.

    2015-01-01

    Full Text Available Contemporary research in the field of explosive applications implies utilization of hydrocode simulations. Validity of these simulations strongly depends on parameters used in the equation of state for high explosives considered. A new analytical model for determination of Jones-Wilkins-Lee (JWL equation of state parameters based on the cylinder test is proposed. The model relies on analysis of the metal cylinder expansion by detonation products. Available cylinder test data for five high explosives are used for the calculation of JWL parameters. Good agreement between results of the model and the literature data is observed, justifying the suggested analytical approach. Numerical finite element model of the cylinder test is created in Abaqus in order to validate the proposed model. Using the analytical model results as the input, it was shown that numerical simulation of the cylinder test accurately reproduces experimental results for all considered high explosives. Therefore, both the analytical method for calculation of JWL equation of state parameters and numerical Abaqus model of the cylinder test are validated. [Projekat Ministartsva nauke Republike Srbije, br. III-47029

  6. A Cramer Rao analysis on receiver placement in a FM band commensal radar system based on doppler only measurements

    CSIR Research Space (South Africa)

    Maasdorp, FDV

    2014-10-01

    Full Text Available to derive the theoretical achievable bound for a given receiver configuration and used as a basis to select the optimal receiver placement. Theoretical concepts such as Shannon entropy and Cramer-Rao analysis are explained and used in the selection process...

  7. SOMFlow: Guided Exploratory Cluster Analysis with Self-Organizing Maps and Analytic Provenance.

    Science.gov (United States)

    Sacha, Dominik; Kraus, Matthias; Bernard, Jurgen; Behrisch, Michael; Schreck, Tobias; Asano, Yuki; Keim, Daniel A

    2018-01-01

    Clustering is a core building block for data analysis, aiming to extract otherwise hidden structures and relations from raw datasets, such as particular groups that can be effectively related, compared, and interpreted. A plethora of visual-interactive cluster analysis techniques has been proposed to date, however, arriving at useful clusterings often requires several rounds of user interactions to fine-tune the data preprocessing and algorithms. We present a multi-stage Visual Analytics (VA) approach for iterative cluster refinement together with an implementation (SOMFlow) that uses Self-Organizing Maps (SOM) to analyze time series data. It supports exploration by offering the analyst a visual platform to analyze intermediate results, adapt the underlying computations, iteratively partition the data, and to reflect previous analytical activities. The history of previous decisions is explicitly visualized within a flow graph, allowing to compare earlier cluster refinements and to explore relations. We further leverage quality and interestingness measures to guide the analyst in the discovery of useful patterns, relations, and data partitions. We conducted two pair analytics experiments together with a subject matter expert in speech intonation research to demonstrate that the approach is effective for interactive data analysis, supporting enhanced understanding of clustering results as well as the interactive process itself.

  8. Analytical and Numerical Design Analysis of Concentric Tube Heat Exchangers – A Review

    Science.gov (United States)

    Silaipillayarputhur, Karthik; Mughanam, Tawfiq Al; Mojil, Abdulaziz Al; Dhmoush, Mohammed Al

    2017-12-01

    This paper considers an analytical and a numerical approach in the design of a concentric tube heat exchanger. Sensible heat transfer is considered in the analysis and the heat exchanger is developed for actual operating conditions in a chemical plant. The heat exchanger is a concentric tube heat exchanger where hot oil exchanges heat with hot water. Hot oil is in the inner pipe and the heating medium, hot water, is in the outer pipe (annular side) of the heat exchanger. An analytical model employing effectiveness-number of transfer units (ε-NTU) approach and log mean temperature difference (LMTD) approach were employed in the design of the concentric tube heat exchanger. In the design process, performance charts were developed for concentric tube heat exchanger. Performance charts describe the performance of the heat exchanger in terms of crucial dimensionless parameters. Performance charts help to select the right number of transfer units (NTU) for the given heat exchanger. Both parallel and counter flow configurations were considered for the design analysis. Likewise, a numerical model was also considered in the design of the heat exchanger. The results from the analysis are presented and compared. From the results it can be seen that both numerical and analytical approaches produce the exact same results. The designer certainly has the flexibility to choose an appropriate design methodology based on the available inputs and requirements.

  9. Application of quantum dots as analytical tools in automated chemical analysis: a review.

    Science.gov (United States)

    Frigerio, Christian; Ribeiro, David S M; Rodrigues, S Sofia M; Abreu, Vera L R G; Barbosa, João A C; Prior, João A V; Marques, Karine L; Santos, João L M

    2012-07-20

    Colloidal semiconductor nanocrystals or quantum dots (QDs) are one of the most relevant developments in the fast-growing world of nanotechnology. Initially proposed as luminescent biological labels, they are finding new important fields of application in analytical chemistry, where their photoluminescent properties have been exploited in environmental monitoring, pharmaceutical and clinical analysis and food quality control. Despite the enormous variety of applications that have been developed, the automation of QDs-based analytical methodologies by resorting to automation tools such as continuous flow analysis and related techniques, which would allow to take advantage of particular features of the nanocrystals such as the versatile surface chemistry and ligand binding ability, the aptitude to generate reactive species, the possibility of encapsulation in different materials while retaining native luminescence providing the means for the implementation of renewable chemosensors or even the utilisation of more drastic and even stability impairing reaction conditions, is hitherto very limited. In this review, we provide insights into the analytical potential of quantum dots focusing on prospects of their utilisation in automated flow-based and flow-related approaches and the future outlook of QDs applications in chemical analysis. Copyright © 2012 Elsevier B.V. All rights reserved.

  10. Assessment of dysregulated children using the Child Behavior Checklist: a receiver operating characteristic curve analysis.

    Science.gov (United States)

    Althoff, Robert R; Ayer, Lynsay A; Rettew, David C; Hudziak, James J

    2010-09-01

    Disorders of self-regulatory behavior are common reasons for referral to child and adolescent clinicians. Here, the authors sought to compare 2 methods of empirically based assessment of children with problems in self-regulatory behavior. Using parental reports on 2,028 children (53% boys) from a U.S. national probability sample of the Child Behavior Checklist (CBCL; T. M. Achenbach & L. A. Rescorla, 2001), the receiver operating characteristic curve analysis was applied to compare scores on the Posttraumatic Stress Problems Scale (PTSP) of the CBCL with the CBCL Dysregulation Profile (DP), identified using latent class analysis of the Attention Problems, Aggressive Behavior, and Anxious/Depressed scales of the CBCL. The CBCL-PTSP score demonstrated an area under the curve of between .88 and .91 for predicting membership in the CBCL-DP profile for boys and for girls. These findings suggest that the CBCL-PTSP, which others have shown does not uniquely identify children who have been traumatized, does identify the same profile of behavior as the CBCL-DP. Therefore, the authors recommend renaming the CBCL-PTSP the Dysregulation Short Scale and provide some guidelines for the use of the CBCL-DP scale and the CBCL-PTSP in clinical practice.

  11. Receiver operating characteristic analysis of eyewitness memory: comparing the diagnostic accuracy of simultaneous versus sequential lineups.

    Science.gov (United States)

    Mickes, Laura; Flowe, Heather D; Wixted, John T

    2012-12-01

    A police lineup presents a real-world signal-detection problem because there are two possible states of the world (the suspect is either innocent or guilty), some degree of information about the true state of the world is available (the eyewitness has some degree of memory for the perpetrator), and a decision is made (identifying the suspect or not). A similar state of affairs applies to diagnostic tests in medicine because, in a patient, the disease is either present or absent, a diagnostic test yields some degree of information about the true state of affairs, and a decision is made about the presence or absence of the disease. In medicine, receiver operating characteristic (ROC) analysis is the standard method for assessing diagnostic accuracy. By contrast, in the eyewitness memory literature, this powerful technique has never been used. Instead, researchers have attempted to assess the diagnostic performance of different lineup procedures using methods that cannot identify the better procedure (e.g., by computing a diagnosticity ratio). Here, we describe the basics of ROC analysis, explaining why it is needed and showing how to use it to measure the performance of different lineup procedures. To illustrate the unique advantages of this technique, we also report 3 ROC experiments that were designed to investigate the diagnostic accuracy of simultaneous versus sequential lineups. According to our findings, the sequential procedure appears to be inferior to the simultaneous procedure in discriminating between the presence versus absence of a guilty suspect in a lineup.

  12. [Comparative retrospective analysis of pain afflictions in patients with lumbar discopathy receiving conservative or operative therapies].

    Science.gov (United States)

    Radziszewski, Krzysztof Roch

    2006-10-01

    Pain afflictions are the basic problems in patients with discopathy of the lumbar backbone. Pain control is the key therapeutic task in patients with a disease of the intervertebral disc. Degree of reduction of the pain sensations is one of the most important criteria in assessment of the treatment efficacy. of this study was to evaluate the pain afflictions in patients with lumbar discopathy treated with conservative and operative therapies. 665 patients aged between 16 and 76 years with discopathy at L4-L5 and L5-S1 levels have been enrolled to the study. In estimated group 348 patients received only a conservative therapy whereas 317 patients undergone an operative procedure. Analysis has been performed based on pain rating scores: Low Back Pain Rating Scale (LBPRS), Japanese Orthopedic Association Low Back Pain Score (JOA-LBPS), Domial's pain rating score. Results of performed studies show that conservative and operative treatment significantly alleviate pain affliction in patients with lumbar discopathy. Complete abatement of pain afflictions more frequent refers to operated patients than those only receiving conservative therapy. Alleviation of pain afflictions within a period of three years following operating procedure is significantly higher than within analogous period of conservative treatment. Reduction of pain obtained as a result of surgical procedure in higher degree refers to limb than backbone. Treatment method does not exert an influence on nature of pain afflictions within distant period. Alleviation of pain afflictions within a period of three years following operating procedure is significantly higher than within analogous period of conservative treatment. Treatment method does not exert an influence on nature of pain afflictions within distant period. Patients at the age of above 50 notify the higher level of intensity of pain ailments than young patients and patients in mid age.

  13. Analytical Round Robin for Elastic-Plastic Analysis of Surface Cracked Plates: Phase I Results

    Science.gov (United States)

    Wells, D. N.; Allen, P. A.

    2012-01-01

    An analytical round robin for the elastic-plastic analysis of surface cracks in flat plates was conducted with 15 participants. Experimental results from a surface crack tension test in 2219-T8 aluminum plate provided the basis for the inter-laboratory study (ILS). The study proceeded in a blind fashion given that the analysis methodology was not specified to the participants, and key experimental results were withheld. This approach allowed the ILS to serve as a current measure of the state of the art for elastic-plastic fracture mechanics analysis. The analytical results and the associated methodologies were collected for comparison, and sources of variability were studied and isolated. The results of the study revealed that the J-integral analysis methodology using the domain integral method is robust, providing reliable J-integral values without being overly sensitive to modeling details. General modeling choices such as analysis code, model size (mesh density), crack tip meshing, or boundary conditions, were not found to be sources of significant variability. For analyses controlled only by far-field boundary conditions, the greatest source of variability in the J-integral assessment is introduced through the constitutive model. This variability can be substantially reduced by using crack mouth opening displacements to anchor the assessment. Conclusions provide recommendations for analysis standardization.

  14. Application of Learning Analytics Using Clustering Data Mining for Students' Disposition Analysis

    Science.gov (United States)

    Bharara, Sanyam; Sabitha, Sai; Bansal, Abhay

    2018-01-01

    Learning Analytics (LA) is an emerging field in which sophisticated analytic tools are used to improve learning and education. It draws from, and is closely tied to, a series of other fields of study like business intelligence, web analytics, academic analytics, educational data mining, and action analytics. The main objective of this research…

  15. Approximate analytical solution of diffusion equation with fractional time derivative using optimal homotopy analysis method

    Directory of Open Access Journals (Sweden)

    S. Das

    2013-12-01

    Full Text Available In this article, optimal homotopy-analysis method is used to obtain approximate analytic solution of the time-fractional diffusion equation with a given initial condition. The fractional derivatives are considered in the Caputo sense. Unlike usual Homotopy analysis method, this method contains at the most three convergence control parameters which describe the faster convergence of the solution. Effects of parameters on the convergence of the approximate series solution by minimizing the averaged residual error with the proper choices of parameters are calculated numerically and presented through graphs and tables for different particular cases.

  16. Social cognition and the cerebellum: A meta-analytic connectivity analysis.

    Science.gov (United States)

    Van Overwalle, Frank; D'aes, Tine; Mariën, Peter

    2015-12-01

    This meta-analytic connectivity modeling (MACM) study explores the functional connectivity of the cerebellum with the cerebrum in social cognitive processes. In a recent meta-analysis, Van Overwalle, Baetens, Mariën, and Vandekerckhove (2014) documented that the cerebellum is implicated in social processes of "body" reading (mirroring; e.g., understanding other persons' intentions from observing their movements) and "mind" reading (mentalizing, e.g., inferring other persons' beliefs, intentions or personality traits, reconstructing persons' past, future, or hypothetical events). In a recent functional connectivity study, Buckner et al. (2011) offered a novel parcellation of cerebellar topography that substantially overlaps with the cerebellar meta-analytic findings of Van Overwalle et al. (2014). This overlap suggests that the involvement of the cerebellum in social reasoning depends on its functional connectivity with the cerebrum. To test this hypothesis, we explored the meta-analytic co-activations as indices of functional connectivity between the cerebellum and the cerebrum during social cognition. The MACM results confirm substantial and distinct connectivity with respect to the functions of (a) action understanding ("body" reading) and (b) mentalizing ("mind" reading). The consistent and strong connectivity findings of this analysis suggest that cerebellar activity during social judgments reflects distinct mirroring and mentalizing functionality, and that these cerebellar functions are connected with corresponding functional networks in the cerebrum. © 2015 Wiley Periodicals, Inc.

  17. Analysis and synthesis of bianisotropic metasurfaces by using analytical approach based on equivalent parameters

    Science.gov (United States)

    Danaeifar, Mohammad; Granpayeh, Nosrat

    2018-03-01

    An analytical method is presented to analyze and synthesize bianisotropic metasurfaces. The equivalent parameters of metasurfaces in terms of meta-atom properties and other specifications of metasurfaces are derived. These parameters are related to electric, magnetic, and electromagnetic/magnetoelectric dipole moments of the bianisotropic media, and they can simplify the analysis of complicated and multilayer structures. A metasurface of split ring resonators is studied as an example demonstrating the proposed method. The optical properties of the meta-atom are explored, and the calculated polarizabilities are applied to find the reflection coefficient and the equivalent parameters of the metasurface. Finally, a structure consisting of two metasurfaces of the split ring resonators is provided, and the proposed analytical method is applied to derive the reflection coefficient. The validity of this analytical approach is verified by full-wave simulations which demonstrate good accuracy of the equivalent parameter method. This method can be used in the analysis and synthesis of bianisotropic metasurfaces with different materials and in different frequency ranges by considering electric, magnetic, and electromagnetic/magnetoelectric dipole moments.

  18. Test and Performance Analysis Methods of Low Earth Orbit GPS Receiver

    OpenAIRE

    Dae-Won Chung; Sang-Jeong Lee

    2006-01-01

    The use of GPS receiver at outer space becomes common in low earth orbit. Recently most of satellites use GPS receiver as navigation solution for finding satellite position. However, the accuracy of navigation solution acquiring directly from GPS receiver is not enough in satellite application such as map generation. Post-processing concepts such as Precise Orbit Determination (POD) are recently applied to satellite data processing to improve satellite position accuracy. The POD uses raw meas...

  19. An Analytical Time Domain Solution for the Forced Vibration Analysis of Thick-Walled Cylinders

    Directory of Open Access Journals (Sweden)

    Bashir Movahedian

    Full Text Available Abstract In this paper, we propose a time domain analytical solution for the forced vibration analysis of thick-walled hollow cylinders in presence of polar orthotropy. In this regard, solution of the governing equation is decomposed into two parts. The role of the first one is to satisfy boundary conditions utilizing the method of separation of variables besides of Fourier series expansion of the non-homogenous boundary conditions. The second part has been also expressed as the series of orthogonal characteristic functions with the aim of satisfaction of initial conditions. The proposed analytical solution has been implemented to evaluate the dynamic response of the cylinder in solution of some sample problems which are chosen from previous studies.

  20. Evaluating risk assessments using receiver operating characteristic analysis: rationale, advantages, insights, and limitations.

    Science.gov (United States)

    Mossman, Douglas

    2013-01-01

    The last two decades have witnessed major changes in the way that mental health professionals assess, describe, and think about persons' risk for future violence. Psychiatrists and psychologists have gone from believing that they could not predict violence to feeling certain they can assess violence risk with well-above-chance accuracy. Receiver operating characteristic (ROC) analysis has played a central role in changing this view. This article reviews the key concepts underlying ROC methods, the meaning of the area under the ROC curve (AUC), the relationship between AUC and effect size d, and what these two indices tell us about evaluations of violence risk. The area under the ROC curve and d provide succinct but incomplete descriptions of discrimination capacity. These indices do not provide details about sensitivity-specificity trade-offs; they do not tell us how to balance false-positive and false-negative errors; and they do not determine whether a diagnostic system is accurate enough to make practically useful distinctions between violent and non-violent subject groups. Justifying choices or clinical practices requires a contextual investigation of outcomes, a process that takes us beyond simply knowing global indices of accuracy. Copyright © 2013 John Wiley & Sons, Ltd.

  1. Identifying indicators of harmful and problem gambling in a Canadian sample through receiver operating characteristic analysis.

    Science.gov (United States)

    Quilty, Lena C; Avila Murati, Daniela; Bagby, R Michael

    2014-03-01

    Many gamblers would prefer to reduce gambling on their own rather than to adopt an abstinence approach within the context of a gambling treatment program. Yet responsible gambling guidelines lack quantifiable markers to guide gamblers in wagering safely. To address these issues, the current investigation implemented receiver operating characteristic (ROC) analysis to identify behavioral indicators of harmful and problem gambling. Gambling involvement was assessed in 503 participants (275 psychiatric outpatients and 228 community gamblers) with the Canadian Problem Gambling Index. Overall gambling frequency, duration, and expenditure were able to distinguish harmful and problematic gambling at a moderate level. Indicators of harmful gambling were generated for engagement in specific gambling activities: frequency of tickets and casino; duration of bingo, casino, and investments; and expenditures on bingo, casino, sports betting, games of skill, and investments. Indicators of problem gambling were similarly produced for frequency of tickets and casino, and expenditures on bingo, casino, games of skill, and investments. Logistic regression analyses revealed that overall gambling frequency uniquely predicted the presence of harmful and problem gambling. Furthermore, frequency indicators for tickets and casino uniquely predicted the presence of both harmful and problem gambling. Together, these findings contribute to the development of an empirically based method enabling the minimization of harmful or problem gambling through self-control rather than abstinence.

  2. Analysis of chromosomal aberrations frequency, haematological parameters and received doses by nuclear medicine professionals.

    Science.gov (United States)

    Djokovic-Davidovic, Jelena; Milovanovic, Andjela; Milovanovic, Jovica; Antic, Vojislav; Gajic, Milan

    2016-01-01

    The purpose of this article was to analyse the impact of low-dose ionizing radiation to nuclear medicine professionals of the Nuclear Medicine Centre of Serbia (NMCRS). Data from the previous/initial and the last medical check-ups, obtained from the medical records of 65 employees from NMCRS, were analysed. A typical checkup, haematological parameters analysis, as well as special cytogenetical analyses, such as unstable chromosomal aberrations and micronucleus test, were carried out. For analyses of chromosomal aberrations the modified Moorhead's micro method was applied to the culture of peripheral blood lymphocytes and conventional cytogenetic technique of chromosomal aberrations was applied. The received cumulative 5-year dose was measured by personal inactive thermoluminescent dosimeters (TLD) calibrated into personal doses equivalent Hp(10). An increased frequency of all unstable chromosomal aberration forms, such as acentric chromosomes and isochromatid lesions, was noticed in the last periodical check-up as compared to the previous/initial checkups (pNuclear medicine employees have increased health risks and there is a need to monitor their health condition by periodical check-ups for prevention from occupational diseases (carcinoma).

  3. Space Trajectories Error Analysis (STEAP) Programs. Volume 1: Analytic manual, update

    Science.gov (United States)

    1971-01-01

    Manual revisions are presented for the modified and expanded STEAP series. The STEAP 2 is composed of three independent but related programs: NOMAL for the generation of n-body nominal trajectories performing a number of deterministic guidance events; ERRAN for the linear error analysis and generalized covariance analysis along specific targeted trajectories; and SIMUL for testing the mathematical models used in the navigation and guidance process. The analytic manual provides general problem description, formulation, and solution and the detailed analysis of subroutines. The programmers' manual gives descriptions of the overall structure of the programs as well as the computational flow and analysis of the individual subroutines. The user's manual provides information on the input and output quantities of the programs. These are updates to N69-36472 and N69-36473.

  4. Analytical methods in sphingolipidomics: Quantitative and profiling approaches in food analysis.

    Science.gov (United States)

    Canela, Núria; Herrero, Pol; Mariné, Sílvia; Nadal, Pedro; Ras, Maria Rosa; Rodríguez, Miguel Ángel; Arola, Lluís

    2016-01-08

    In recent years, sphingolipidomics has emerged as an interesting omic science that encompasses the study of the full sphingolipidome characterization, content, structure and activity in cells, tissues or organisms. Like other omics, it has the potential to impact biomarker discovery, drug development and systems biology knowledge. Concretely, dietary food sphingolipids have gained considerable importance due to their extensively reported bioactivity. Because of the complexity of this lipid family and their diversity among foods, powerful analytical methodologies are needed for their study. The analytical tools developed in the past have been improved with the enormous advances made in recent years in mass spectrometry (MS) and chromatography, which allow the convenient and sensitive identification and quantitation of sphingolipid classes and form the basis of current sphingolipidomics methodologies. In addition, novel hyphenated nuclear magnetic resonance (NMR) strategies, new ionization strategies, and MS imaging are outlined as promising technologies to shape the future of sphingolipid analyses. This review traces the analytical methods of sphingolipidomics in food analysis concerning sample extraction, chromatographic separation, the identification and quantification of sphingolipids by MS and their structural elucidation by NMR. Copyright © 2015 Elsevier B.V. All rights reserved.

  5. Transverse plane wave analysis of short elliptical chamber mufflers: An analytical approach

    Science.gov (United States)

    Mimani, A.; Munjal, M. L.

    2011-03-01

    Short elliptical chamber mufflers are used often in the modern day automotive exhaust systems. The acoustic analysis of such short chamber mufflers is facilitated by considering a transverse plane wave propagation model along the major axis up to the low frequency limit. The one dimensional differential equation governing the transverse plane wave propagation in such short chambers is solved using the segmentation approaches which are inherently numerical schemes, wherein the transfer matrix relating the upstream state variables to the downstream variables is obtained. Analytical solution of the transverse plane wave model used to analyze such short chambers has not been reported in the literature so far. This present work is thus an attempt to fill up this lacuna, whereby Frobenius solution of the differential equation governing the transverse plane wave propagation is obtained. By taking a sufficient number of terms of the infinite series, an approximate analytical solution so obtained shows good convergence up to about 1300 Hz and also covers most of the range of muffler dimensions used in practice. The transmission loss (TL) performance of the muffler configurations computed by this analytical approach agrees excellently with that computed by the Matrizant approach used earlier by the authors, thereby offering a faster and more elegant alternate method to analyze short elliptical muffler configurations.

  6. Long-time analytic approximation of large stochastic oscillators: Simulation, analysis and inference.

    Directory of Open Access Journals (Sweden)

    Giorgos Minas

    2017-07-01

    Full Text Available In order to analyse large complex stochastic dynamical models such as those studied in systems biology there is currently a great need for both analytical tools and also algorithms for accurate and fast simulation and estimation. We present a new stochastic approximation of biological oscillators that addresses these needs. Our method, called phase-corrected LNA (pcLNA overcomes the main limitations of the standard Linear Noise Approximation (LNA to remain uniformly accurate for long times, still maintaining the speed and analytically tractability of the LNA. As part of this, we develop analytical expressions for key probability distributions and associated quantities, such as the Fisher Information Matrix and Kullback-Leibler divergence and we introduce a new approach to system-global sensitivity analysis. We also present algorithms for statistical inference and for long-term simulation of oscillating systems that are shown to be as accurate but much faster than leaping algorithms and algorithms for integration of diffusion equations. Stochastic versions of published models of the circadian clock and NF-κB system are used to illustrate our results.

  7. Information theory in analytical chemistry

    National Research Council Canada - National Science Library

    Eckschlager, Karel; Danzer, Klaus

    1994-01-01

    Contents: The aim of analytical chemistry - Basic concepts of information theory - Identification of components - Qualitative analysis - Quantitative analysis - Multicomponent analysis - Optimum analytical...

  8. Preliminary analysis of the operating characteristics of a generic repository receiving facility: Status report

    International Nuclear Information System (INIS)

    1985-10-01

    The operating characteristics of a repository receiving facility structured around current technology and practices have been reviewed. Cask turnaround times and operator doses were estimated. Large throughout and long-term receiving operations at a nuclear waste repository result in an unprecedented number of casks being handled. While the current generation of material-handling equipment is adequate to process the casks, personnel radiation exposures for the generic facility analyzed are unacceptably high. This emphasizes the need for development of occupational radiation exposure control concepts for application in repository receiving facilities. 3 refs., 22 figs., 6 tabs

  9. Transient analysis of a molten salt central receiver (MSCR) in a solar power plant

    Science.gov (United States)

    Joshi, A.; Wang, C.; Akinjiola, O.; Lou, X.; Neuschaefer, C.; Quinn, J.

    2016-05-01

    Alstom is developing solar power tower plants utilizing molten salt as the working fluid. In solar power tower, the molten salt central receiver (MSCR) atop of the tower is constructed of banks of tubes arranged in panels creating a heat transfer surface exposed to the solar irradiation from the heliostat field. The molten salt heat transfer fluid (HTF), in this case 60/40%wt NaNO3-KNO3, flows in serpentine flow through the surface collecting sensible heat thus raising the HTF temperature from 290°C to 565°C. The hot molten salt is stored and dispatched to produce superheated steam in a steam generator, which in turn produces electricity in the steam turbine generator. The MSCR based power plant with a thermal energy storage system (TESS) is a fully dispatchable renewable power plant with a number of opportunities for operational and economic optimization. This paper presents operation and controls challenges to the MSCR and the overall power plant, and the use of dynamic model computer simulation based transient analyses applied to molten salt based solar thermal power plant. This study presents the evaluation of the current MSCR design, using a dynamic model, with emphasis on severe events affecting critical process response, such as MS temperature deviations, and recommend MSCR control design improvements based on the results. Cloud events are the scope of the transient analysis presented in this paper. The paper presents results from a comparative study to examine impacts or effects on key process variables related to controls and operation of the MSCR plant.

  10. Books Received

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education. Books Received. Articles in Resonance – Journal of Science Education. Volume 1 Issue 1 January 1996 pp 118-118 Books Received. Books Received · More Details Fulltext PDF. Volume 1 Issue 2 February 1996 pp 120-120 Books Received. Books Received.

  11. Experimental analysis of THz receiver performance in 80 Gbit/s communication system

    DEFF Research Database (Denmark)

    Jia, Shi; Yu, Xianbin; Hu, Hao

    2016-01-01

    We experimentally analyze the performance of Schottky mixer-based THz receiver in a high-speed THz wireless transmission system incorporating an ultra-broadband uni-travelling carrier photodiode (UTC-PD) as photo-mixing emitter. The multi-channel photonic THz wireless system operates in the 375–4...... in the receiver however severely affects the receiver bandwidth and induces the performance degradation of THz wireless communication systems.......We experimentally analyze the performance of Schottky mixer-based THz receiver in a high-speed THz wireless transmission system incorporating an ultra-broadband uni-travelling carrier photodiode (UTC-PD) as photo-mixing emitter. The multi-channel photonic THz wireless system operates in the 375...

  12. Analysis of parallel optical sampling rate and ADC requirements in digital coherent receivers

    DEFF Research Database (Denmark)

    Lorences Riesgo, Abel; Galili, Michael; Peucheret, Christophe

    2012-01-01

    We comprehensively assess analog-to-digital converter requirements in coherent digital receiver schemes with parallel optical sampling. We determine the electronic requirements in accordance with the properties of the free running local oscillator....

  13. Performance analysis of MRC spatial diversity receiver system for satellite-to-ground downlink optical transmissions

    Science.gov (United States)

    Li, Kangning; Ma, Jing; Tan, Liying; Yu, Siyuan; Cao, Yubin

    2016-10-01

    The performances of satellite-to-ground downlink optical communications over Gamma-Gamma distributed turbulence are studied for multiple apertures receiver system. Maximum ratio combining (MRC) technique is considered as a combining scheme to mitigate the atmospheric turbulence under thermal noise limited conditions. Bit-error rate (BER) performances for on-off keying (OOK) modulated direct detection optical communications are analyzed for MRC diversity receptions through an approximation method. To show the net diversity gain of multiple apertures receiver system, BER performances of MRC receiver system are compared with a single monolithic aperture receiver system with the same total aperture area (same average total incident optical power) for satellite-to-ground downlink optical communications. All the numerical results are also verified by Monte-Carlo (MC) simulations.

  14. Sensitivity analysis of technological, economic and sustainability evaluation of power plants using the analytic hierarchy process

    International Nuclear Information System (INIS)

    Chatzimouratidis, Athanasios I.; Pilavachi, Petros A.

    2009-01-01

    Technological, economic and sustainability evaluation of power plants by use of the analytic hierarchy process and nine end node criteria for a reference scenario based on subjective criteria weighting has been presented in a previous paper by authors. However, criteria weight variations may substantially modify overall evaluations and rankings of power plants. The current paper presents a sensitivity analysis with four alternative scenarios (sets of criteria weights) compared with the reference scenario. The results show that priority to 'technology and sustainability' favors renewable energy power plants, while priority to 'economic' criteria favors mainly nuclear power plants and less the four types of fossil fuel power plant

  15. Selection of analytical methods for mixed waste analysis at the Hanford Site

    Energy Technology Data Exchange (ETDEWEB)

    Morant, P.M.

    1994-09-01

    This document describes the process that the US Department of Energy (DOE), Richland Operations Office (RL) and contractor laboratories use to select appropriate or develop new or modified analytical methods. These methods are needed to provide reliable mixed waste characterization data that meet project-specific quality assurance (QA) requirements while also meeting health and safety standards for handling radioactive materials. This process will provide the technical basis for DOE`s analysis of mixed waste and support requests for regulatory approval of these new methods when they are used to satisfy the regulatory requirements of the Hanford Federal Facility Agreement and Consent Order (Tri-party Agreement) (Ecology et al. 1992).

  16. Emanation thermal analysis. Application in solid state chemistry, analytical chemistry and engineering

    International Nuclear Information System (INIS)

    Balek, V.; Tel'deshi, Yu.

    1986-01-01

    Voluminous material on application of emenation thermal analysis for investigation of solids is systematized. General concepts and historical review of development of the method are given. Methods of introduction of inert gases into solids are considered. Theoretical aspects of inert gas evolution from solids labelled by radioactive gas or its maternal isotope are stated. The methods for measuring inert gases are considered. The possibilities, limitations and perspectives of development of radiometric emanation methods for the solution of various problems of analytical chemistry and thechnology are discussed

  17. Waste Receiving and Processing (WRAP) Facility Weight Scale Analysis Fairbanks Weight Scale Evaluation Results

    International Nuclear Information System (INIS)

    JOHNSON, M.D.

    1999-01-01

    Fairbanks Weight Scales are used at the Waste Receiving and Processing (WRAP) facility to determine the weight of waste drums as they are received, processed, and shipped. Due to recent problems, discovered during calibration, the WRAP Engineering Department has completed this document which outlines both the investigation of the infeed conveyor scale failure in September of 1999 and recommendations for calibration procedure modifications designed to correct deficiencies in the current procedures

  18. Development of an Automated LIBS Analytical Test System Integrated with Component Control and Spectrum Analysis Capabilities

    International Nuclear Information System (INIS)

    Ding Yu; Tian Di; Chen Feipeng; Chen Pengfei; Qiao Shujun; Yang Guang; Li Chunsheng

    2015-01-01

    The present paper proposes an automated Laser-Induced Breakdown Spectroscopy (LIBS) analytical test system, which consists of a LIBS measurement and control platform based on a modular design concept, and a LIBS qualitative spectrum analysis software and is developed in C#. The platform provides flexible interfacing and automated control; it is compatible with different manufacturer component models and is constructed in modularized form for easy expandability. During peak identification, a more robust peak identification method with improved stability in peak identification has been achieved by applying additional smoothing on the slope obtained by calculation before peak identification. For the purpose of element identification, an improved main lines analysis method, which detects all elements on the spectral peak to avoid omission of certain elements without strong spectral lines, is applied to element identification in the tested LIBS samples. This method also increases the identification speed. In this paper, actual applications have been carried out. According to tests, the analytical test system is compatible with components of various models made by different manufacturers. It can automatically control components to get experimental data and conduct filtering, peak identification and qualitative analysis, etc. on spectral data. (paper)

  19. Experimental vs. analytical modal analysis of a composite circumferentially asymmetric stiffness box beam

    Science.gov (United States)

    Latalski, Jarosław; Kowalczuk, Marcin

    2018-01-01

    This paper presents a theoretical vs. experimental modal analysis of a composite thin-walled beam featuring a circumfer-entially asymmetric stiffness (CAS) profile characteristics. The adopted lamination scheme results in the complex elastic deformation modes exhibiting mutual coupling of flapwise bending, transverse shear and torsion. The analytical model used in this study is based on the authors previous research and takes into account most classical and non-classical effects specific for thin-walled composite structures. The theoretical outcomes are compared to experimental ones obtained by two different test methods, namely an impact hammer test and a laser vibrometer test. In this second experiment the macro fibre composite (MFC) patch actuators have been used to excite the system. For comparative purposes two different transducer types providing different excitation load have been examined. The performed analytical and laboratory experiments demonstrate extremely high consistent findings irrespective of the means of excitation. Therefore, the laser-based motion analysis system combined with piezo-actuator excitation may be considered as a feasible and accurate method for static and dynamic experiments on systems exhibiting complex deformation modes. These include also highly flexible structures where the deformations can not be measured by conventional contact methods e.g. due to the influence of an accelerometer mass. The discussed laser-based motion measuring technique can also be used in future modal analysis experiments on rotating beams.

  20. Parametric Analysis of Cyclic Phase Change and Energy Storage in Solar Heat Receivers

    Science.gov (United States)

    Hall, Carsie A., III; Glakpe, Emmanuel K.; Cannon, Joseph N.; Kerslake, Thomas W.

    1997-01-01

    A parametric study on cyclic melting and freezing of an encapsulated phase change material (PCM), integrated into a solar heat receiver, has been performed. The cyclic nature of the present melt/freeze problem is relevant to latent heat thermal energy storage (LHTES) systems used to power solar Brayton engines in microgravity environments. Specifically, a physical and numerical model of the solar heat receiver component of NASA Lewis Research Center's Ground Test Demonstration (GTD) project was developed. Multi-conjugate effects such as the convective fluid flow of a low-Prandtl-number fluid, coupled with thermal conduction in the phase change material, containment tube and working fluid conduit were accounted for in the model. A single-band thermal radiation model was also included to quantify reradiative energy exchange inside the receiver and losses through the aperture. The eutectic LiF-CaF2 was used as the phase change material (PCM) and a mixture of He/Xe was used as the working fluid coolant. A modified version of the computer code HOTTube was used to generate results in the two-phase regime. Results indicate that parametric changes in receiver gas inlet temperature and receiver heat input effects higher sensitivity to changes in receiver gas exit temperatures.

  1. Sampling and analytical methodologies for instrumental neutron activation analysis of airborne particulate matter

    International Nuclear Information System (INIS)

    1992-01-01

    The IAEA supports a number of projects having to do with the analysis of airborne particulate matter by nuclear techniques. Most of this work involves the use of activation analysis in its various forms, particularly instrumental neutron activation analysis (INAA). This technique has been widely used in many different countries for the analysis of airborne particulate matter, and there are already many publications in scientific journals, books and reports describing such work. The present document represents an attempt to summarize the most important features of INAA as applied to the analysis of airborne particulate matter. It is intended to serve as a set of guidelines for use by participants in the IAEA's own programmes, and other scientists, who are not yet fully experienced in the application of INAA to airborne particulate samples, and who wish either to make a start on using this technique or to improve their existing procedures. The methodologies for sampling described in this document are of rather general applicability, although they are presented here in a way that takes account of the particular requirements arising from the use of INAA as the analytical technique. The analytical part of the document, however, is presented in a form that is applicable only to INAA. (Subsequent publications in this series are expected to deal specifically with other nuclear related techniques such as energy dispersive X ray fluorescence (ED-XRF) and particle induced X ray emission (PIXE) analysis). Although the methods and procedures described here have been found through experience to yield acceptable results, they should not be considered mandatory. Any other procedure used should, however, be chosen to be capable of yielding results at least of equal quality to those described

  2. Error-analysis and comparison to analytical models of numerical waveforms produced by the NRAR Collaboration

    International Nuclear Information System (INIS)

    Hinder, Ian; Wardell, Barry; Alic, Daniela; Buonanno, Alessandra; Pan, Yi; Boyle, Michael; Etienne, Zachariah B; Healy, James; Johnson-McDaniel, Nathan K; Nagar, Alessandro; Nakano, Hiroyuki; Pfeiffer, Harald P; Pürrer, Michael; Reisswig, Christian; Scheel, Mark A; Sperhake, Ulrich; Szilágyi, Bela; Zenginoğlu, Anıl; Schnetter, Erik; Tichy, Wolfgang

    2013-01-01

    The Numerical–Relativity–Analytical–Relativity (NRAR) collaboration is a joint effort between members of the numerical relativity, analytical relativity and gravitational-wave data analysis communities. The goal of the NRAR collaboration is to produce numerical-relativity simulations of compact binaries and use them to develop accurate analytical templates for the LIGO/Virgo Collaboration to use in detecting gravitational-wave signals and extracting astrophysical information from them. We describe the results of the first stage of the NRAR project, which focused on producing an initial set of numerical waveforms from binary black holes with moderate mass ratios and spins, as well as one non-spinning binary configuration which has a mass ratio of 10. All of the numerical waveforms are analysed in a uniform and consistent manner, with numerical errors evaluated using an analysis code created by members of the NRAR collaboration. We compare previously-calibrated, non-precessing analytical waveforms, notably the effective-one-body (EOB) and phenomenological template families, to the newly-produced numerical waveforms. We find that when the binary's total mass is ∼100–200M ⊙ , current EOB and phenomenological models of spinning, non-precessing binary waveforms have overlaps above 99% (for advanced LIGO) with all of the non-precessing-binary numerical waveforms with mass ratios ⩽4, when maximizing over binary parameters. This implies that the loss of event rate due to modelling error is below 3%. Moreover, the non-spinning EOB waveforms previously calibrated to five non-spinning waveforms with mass ratio smaller than 6 have overlaps above 99.7% with the numerical waveform with a mass ratio of 10, without even maximizing on the binary parameters. (paper)

  3. Exact capture probability analysis of GSC receivers over Rayleigh fading channel

    KAUST Repository

    Nam, Sungsik

    2010-01-01

    For third generation systems and ultrawideband systems, RAKE receivers have been introduced due to the advantage of RAKE receivers which is their ability to combine different replicas of the transmitted signal arriving at different delays in a rich multipath environment. In principle, RAKE receivers combine all resolvable paths which gives the best performance in a rich diversity environment. However, this is usually costly in terms of hardware required as the number of RAKE fingers increases. Therefore, generalized selection combining (GSC) RAKE reception was proposed and has been studied by many researcher as an alternative to the classical two fundamental diversity schemes: maximal ratio combining and selection combining. Previous work on performance analyses of GSC RAKE receivers based on the signal to noise ratio focused on the development of methodologies to derive exact closedform expressions for various performance measures. However, the remaining set of uncombined paths affect the overall performance both in terms of loss in power. Therefore, to have a full understanding of the performance of GSC RAKE receivers, we introduce in this paper the notion of capture probability, which is defined as the ratio of the captured power (essentially combined paths power) to that of the total available power. The major difficulty in these problems is to derive some joint statistics of ordered exponential variates. With this motivation in mind, we capitalize in this paper on some new order statistics results to derive exact closed-form expressions for the capture probability over independent and identically distributed Rayleigh fading channels. © 2010 IEEE.

  4. Bootstrap-based procedures for inference in nonparametric receiver-operating characteristic curve regression analysis.

    Science.gov (United States)

    Rodríguez-Álvarez, María Xosé; Roca-Pardiñas, Javier; Cadarso-Suárez, Carmen; Tahoces, Pablo G

    2018-03-01

    Prior to using a diagnostic test in a routine clinical setting, the rigorous evaluation of its diagnostic accuracy is essential. The receiver-operating characteristic curve is the measure of accuracy most widely used for continuous diagnostic tests. However, the possible impact of extra information about the patient (or even the environment) on diagnostic accuracy also needs to be assessed. In this paper, we focus on an estimator for the covariate-specific receiver-operating characteristic curve based on direct regression modelling and nonparametric smoothing techniques. This approach defines the class of generalised additive models for the receiver-operating characteristic curve. The main aim of the paper is to offer new inferential procedures for testing the effect of covariates on the conditional receiver-operating characteristic curve within the above-mentioned class. Specifically, two different bootstrap-based tests are suggested to check (a) the possible effect of continuous covariates on the receiver-operating characteristic curve and (b) the presence of factor-by-curve interaction terms. The validity of the proposed bootstrap-based procedures is supported by simulations. To facilitate the application of these new procedures in practice, an R-package, known as npROCRegression, is provided and briefly described. Finally, data derived from a computer-aided diagnostic system for the automatic detection of tumour masses in breast cancer is analysed.

  5. Receiver operating characteristic analysis for the detection of simulated microcalcifications on mammograms using hardcopy images

    Energy Technology Data Exchange (ETDEWEB)

    Lai, C J [Department of Imaging Physics, University of Texas M D Anderson Cancer Center, Houston, Texas (United States); Shaw, Chris C [Department of Imaging Physics, University of Texas M D Anderson Cancer Center, Houston, Texas (United States); Whitman, Gary J [Department of Diagnostic Radiology, University of Texas M D Anderson Cancer Center, Houston, Texas (United States); Yang, Wei T [Department of Diagnostic Radiology, University of Texas M D Anderson Cancer Center, Houston, Texas (United States); Dempsey, Peter J [Department of Diagnostic Radiology, University of Texas M D Anderson Cancer Center, Houston, Texas (United States); Nguyen, Victoria [Department of Diagnostic Radiology, University of Texas M D Anderson Cancer Center, Houston, Texas (United States); Ice, Mary F [Department of Diagnostic Radiology, University of Texas M D Anderson Cancer Center, Houston, Texas (United States)

    2006-08-21

    The aim of this study was to compare mammography systems based on three different detectors-a conventional screen-film (SF) combination, an a-Si/CsI flat-panel (FP)-based detector, and a charge-coupled device (CCD)-based x-ray phosphor-based detector-for their performance in detecting simulated microcalcifications (MCs). 112-150 {mu}m calcium carbonate grains were used to simulate MCs and were overlapped with a slab phantom of simulated 50% adipose/50% glandular breast tissue-equivalent material referred to as the uniform background. For the tissue structure background, 200-250 {mu}m calcium carbonate grains were used and overlapped with an anthropomorphic breast phantom. All MC phantom images were acquired with and without magnification (1.8X). The hardcopy images were reviewed by five mammographers. A five-point confidence level rating was used to score each detection task. Receiver operating characteristic (ROC) analysis was performed, and the areas under the ROC curves (A{sub z}s) were used to compare the performances of the three mammography systems under various conditions. The results showed that, with a uniform background and contact images, the FP-based system performed significantly better than the SF and the CCD-based systems. For magnified images with a uniform background, the SF and the FP-based systems performed equally well and significantly better than the CCD-based system. With tissue structure background and contact images, the SF system performed significantly better than the FP and the CCD-based systems. With magnified images and a tissue structure background, the SF and the CCD-based systems performed equally well and significantly better than the FP-based system. In the detection of MCs in the fibroglandular and the heterogeneously dense regions, no significant differences were found except that the SF system performed significantly better than the CCD-based system in the fibroglandular regions for the contact images.

  6. Semi-analytical finite element analysis of elastic waveguides subjected to axial loads.

    Science.gov (United States)

    Loveday, Philip W

    2009-03-01

    Predicting the influence of axial loads on the wave propagation in structures such as rails requires numerical analysis. Conventional three-dimensional finite element analysis has previously been applied to this problem. The process is tedious as it requires that a number of different length models be solved and that the user identify the computed modes of propagation. In this paper, the more specialised semi-analytical finite element method is extended to account for the effect of axial load. The semi-analytical finite element method includes the wave propagation as a complex exponential in the element formulation and therefore only a two-dimensional mesh of the cross-section of the waveguide is required. It was found that the stiffness matrix required to describe the effect of axial load is proportional to the mass matrix, which makes the extension to existing software trivial. The method was verified by application to an aluminium rod, where after phase and group velocities of propagating waves in a rail were computed to demonstrate the method.

  7. Visual analytics for multimodal social network analysis: a design study with social scientists.

    Science.gov (United States)

    Ghani, Sohaib; Kwon, Bum Chul; Lee, Seungyoon; Yi, Ji Soo; Elmqvist, Niklas

    2013-12-01

    Social network analysis (SNA) is becoming increasingly concerned not only with actors and their relations, but also with distinguishing between different types of such entities. For example, social scientists may want to investigate asymmetric relations in organizations with strict chains of command, or incorporate non-actors such as conferences and projects when analyzing coauthorship patterns. Multimodal social networks are those where actors and relations belong to different types, or modes, and multimodal social network analysis (mSNA) is accordingly SNA for such networks. In this paper, we present a design study that we conducted with several social scientist collaborators on how to support mSNA using visual analytics tools. Based on an openended, formative design process, we devised a visual representation called parallel node-link bands (PNLBs) that splits modes into separate bands and renders connections between adjacent ones, similar to the list view in Jigsaw. We then used the tool in a qualitative evaluation involving five social scientists whose feedback informed a second design phase that incorporated additional network metrics. Finally, we conducted a second qualitative evaluation with our social scientist collaborators that provided further insights on the utility of the PNLBs representation and the potential of visual analytics for mSNA.

  8. Analytical multiple scattering correction to the Mie theory: Application to the analysis of the lidar signal

    Science.gov (United States)

    Flesia, C.; Schwendimann, P.

    1992-01-01

    The contribution of the multiple scattering to the lidar signal is dependent on the optical depth tau. Therefore, the radar analysis, based on the assumption that the multiple scattering can be neglected is limited to cases characterized by low values of the optical depth (tau less than or equal to 0.1) and hence it exclude scattering from most clouds. Moreover, all inversion methods relating lidar signal to number densities and particle size must be modified since the multiple scattering affects the direct analysis. The essential requests of a realistic model for lidar measurements which include the multiple scattering and which can be applied to practical situations follow. (1) Requested are not only a correction term or a rough approximation describing results of a certain experiment, but a general theory of multiple scattering tying together the relevant physical parameter we seek to measure. (2) An analytical generalization of the lidar equation which can be applied in the case of a realistic aerosol is requested. A pure analytical formulation is important in order to avoid the convergency and stability problems which, in the case of numerical approach, are due to the large number of events that have to be taken into account in the presence of large depth and/or a strong experimental noise.

  9. Power Distribution Analysis For Electrical Usage In Province Area Using Olap (Online Analytical Processing)

    Science.gov (United States)

    Samsinar, Riza; Suseno, Jatmiko Endro; Widodo, Catur Edi

    2018-02-01

    The distribution network is the closest power grid to the customer Electric service providers such as PT. PLN. The dispatching center of power grid companies is also the data center of the power grid where gathers great amount of operating information. The valuable information contained in these data means a lot for power grid operating management. The technique of data warehousing online analytical processing has been used to manage and analysis the great capacity of data. Specific methods for online analytics information systems resulting from data warehouse processing with OLAP are chart and query reporting. The information in the form of chart reporting consists of the load distribution chart based on the repetition of time, distribution chart on the area, the substation region chart and the electric load usage chart. The results of the OLAP process show the development of electric load distribution, as well as the analysis of information on the load of electric power consumption and become an alternative in presenting information related to peak load.

  10. Power Distribution Analysis For Electrical Usage In Province Area Using Olap (Online Analytical Processing

    Directory of Open Access Journals (Sweden)

    Samsinar Riza

    2018-01-01

    Full Text Available The distribution network is the closest power grid to the customer Electric service providers such as PT. PLN. The dispatching center of power grid companies is also the data center of the power grid where gathers great amount of operating information. The valuable information contained in these data means a lot for power grid operating management. The technique of data warehousing online analytical processing has been used to manage and analysis the great capacity of data. Specific methods for online analytics information systems resulting from data warehouse processing with OLAP are chart and query reporting. The information in the form of chart reporting consists of the load distribution chart based on the repetition of time, distribution chart on the area, the substation region chart and the electric load usage chart. The results of the OLAP process show the development of electric load distribution, as well as the analysis of information on the load of electric power consumption and become an alternative in presenting information related to peak load.

  11. Receiver Performance Analysis of a Multi-wavelength Sampling Integrated Path Differential Absorption CO2 Lidar

    Science.gov (United States)

    Sun, X.; Abshire, J. B.; Ramanathan, A. K.; Mao, J.; Kawa, S. R.

    2016-12-01

    A multi-wavelength sampling integrated path differential (IPDA) CO2 lidar is analyzed and modeled. The instrument transmits laser pulses at a series of wavelengths across the 1572.33 nm CO2 absorption line. The receiver measures the received laser pulse energy and time of flight at each wavelength. The measurements are then fit to a CO2 absorption line shape to determine the total column CO2 mixing ratio. The receiver model includes effects of solar background, photon detection shot noise, detector dark current, preamplifier noise and laser speckle noise. The least-square curve fit is a linear fit in the optical depth domain and the logarithm of the raw measurements. The column CO2 mixing ratio is proportional to the scaling factor resulted from the curve fit. There are several advantages to performing the curve fit in the optical depth domain: (a) the result is directly proportional to the CO2molecule number density of the column; (b) it is a standard linear least square error fit where the theory is well established; (c) there is no need to separately estimate the off-line optical transmission. The receiver model further gives insight about the effects of various instrument parameters and the difference between the atmosphere model used in the curve fit and the actual atmosphere. For example, we can use the model to estimate the biases in the retrieved CO2 mixing ratio from small errors in the meteorological data used to generate the line shape used in the curve fit. We have shown that the estimated instrument performance using this receiver model agrees with the results from our recent airborne measurements. The receiver model is also used in the simulation of the impact of the lidar measurements of the global greenhouse gas distribution and their projected impact on quantification of surface sources and sinks.

  12. Development of an analytic outline for the aflatoxins analysis in grains and flours

    International Nuclear Information System (INIS)

    Sibaja Adams, Roxana

    2000-01-01

    The instrumental and analytic conditions were optimized for the aflatoxine determination B1, B2, 1 and G2 in corn and peanut byl iquid chromatography of high discharge following the analyzing method AOAC 994,08. Besides, it was defined a function for evaluating the dependence of the chromatographic discharge with the aflatoxine concentration. The analyzing method was validated, and four calibration curves were obtained for the aflatoxine B1, B2, G1 and G2, which turned to have a heterocedastico behavior. The applicability of this method was demonstrated, obtaining imagines of appropriate merit and comparable with those reported by the AOAC. Additionally, the applicability of the chromatographic method was demonstrated in fine layer for the presumptive analysis of aflatoxine, allowing both methods to propose an outline of reliable analysis of real samples [es

  13. Analytical Calculation And FEM Analysis Main Girder Double Girder Bridge Crane

    Directory of Open Access Journals (Sweden)

    Muamer Delić

    2017-02-01

    Full Text Available The cranes are now not replaceable mode of transport of materials and finished products both in production halls and in the open space. This paper made the whole analytical calculation of double girder bridge cranes to be used in laboratories exclusively for testing, determined by the maximum bending stress and deflection of the main girder. After calculating the dimensions, we created a model cranes in software CATIA V5. The same model was subjected to FEM analysis of the same name software. At the end of the paper comparison has been done. The objective of the calculation and analysis of the model was to develop a model crane and to serve for the next tests. Dimensions of the crane are given according to the laboratory where it will be located.

  14. Optical analysis of deviations in a concentrating photovoltaics central receiver system with a flux homogenizer.

    Science.gov (United States)

    Helmers, Henning; Thor, Wei Yi; Schmidt, Thomas; van Rooyen, De Wet; Bett, Andreas W

    2013-05-01

    The application of a kaleidoscope as a flux homogenizer to a concentrating photovoltaics system with a central receiver is investigated. The optical setup of a primary dish-type concentrator, a secondary homogenizer optics, and a photovoltaic receiver is simulated using ray tracing. The influence of various deviations from the ideal-namely sunshape (circumsolar radiation), shading, tracking error, and shape of the primary optical concentrator-on the performance of the homogenizer is analyzed quantitatively using the optical efficiency and the normalized standard deviation as a measure of inhomogeneity. Flux distributions for different progressively increasing deviations are discussed qualitatively. Experimental validation of the simulation is presented. It is demonstrated that the performance of the homogenizer is not particularly sensitive to sunshape. If sufficient length is provided, the homogenizer effectively compensates for tracking error, misalignment, and shape deviations of the primary concentrator. Yet despite the presence of the homogenizer, shading due to the holder of the receiver significantly affects the flux distribution at the receiver.

  15. Complexity analysis for mapping a DRM receiver on a heterogeneous tiled architecture

    NARCIS (Netherlands)

    Wolkotte, P.T.; Smit, Gerardus Johannes Maria; Smit, L.T.

    2004-01-01

    In this article we present the results of partitioning the OFDM baseband processing of a DRM receiver into smaller independent processes. Furthermore, we give a short introduction into the relevant parts of the DRM standard. Based on the number of multiplications and additions we can map individual

  16. Costs of Quality: Exploratory Analysis of Hidden Elements and Prioritization using Analytic Hierarchy Process

    Directory of Open Access Journals (Sweden)

    Sailaja A

    2015-02-01

    Full Text Available Cost of Quality analysis is emerged as an effective tool for the industrial managers for pinpointing the deficiencies in the system as well as for identifying the improvement areas by highlighting the cost reduction opportunities. However , this analysis will be fully effective only if it is further extended to identify the cost incurred in ensuring quality in all areas of the supply chain including the hidden costs and costs of missed out opportunities. Most of the hidden elements of quality costs are difficult to track and not accounted by the traditional accounting tools. An exploratory analysis is made in this research to identify the hidden elements of quality costs in manufacturing industry. Further, the identified cost elements are classified into various groups for better analysis and, finally, prioritized to identify the vital few among them. Analytic Hierarchy Process (AHP technique which is one of the most popular Multi Criteria Decision Method (MCDM and Pareto analysis were used in this study for prioritizing the hidden quality cost elements based on their degree of impact on overall cost of quality. By this analysis, the key cost elements which are to be addressed to reduce the overall cost of quality are identified.

  17. Low-Cost GNSS Receivers for Local Monitoring: Experimental Simulation, and Analysis of Displacements

    Directory of Open Access Journals (Sweden)

    Ludovico Biagi

    2016-12-01

    Full Text Available The geodetic monitoring of local displacements and deformations is often needed for civil engineering structures and natural phenomena like, for example, landslides. A local permanent GNSS (Global Navigation Satellite Systems network can be installed: receiver positions in the interest area are estimated and monitored with respect to reference stations. Usually, GNSS geodetic receivers are adopted and provide results with accuracies at the millimeter level: however, they are very expensive and the initial cost and the risk of damage and loss can discourage this approach. In this paper the accuracy and the reliability of low-cost u-blox GNSS receivers are experimentally investigated for local monitoring. Two experiments are analyzed. In the first, a baseline (65 m long between one geodetic reference receiver and one u-blox is continuously observed for one week: the data are processed by hourly sessions and the results provide comparisons between two processing packages and a preliminary accuracy assessment. Then, a network composed of one geodetic and two u-blox receivers is set up. One u-blox is installed on a device (slide that allows to apply controlled displacements. The geodetic and the other u-blox (at about 130 m act as references. The experiment lasts about two weeks. The data are again processed by hourly sessions. The estimated displacements of the u-blox on the slide are analyzed and compared with the imposed displacements. All of the results are encouraging: in the first experiment the standard deviations of the residuals are smaller than 5 mm both in the horizontal and vertical; in the second, they are slightly worse but still satisfactory (5 mm in the horizontal and 13 mm in vertical and the imposed displacements are almost correctly identified.

  18. Liver transplantation in recipients receiving renal replacement therapy: outcomes analysis and the role of intraoperative hemodialysis.

    Science.gov (United States)

    Agopian, V G; Dhillon, A; Baber, J; Kaldas, F M; Zarrinpar, A; Farmer, D G; Petrowsky, H; Xia, V; Honda, H; Gornbein, J; Hiatt, J R; Busuttil, R W

    2014-07-01

    The Model for End-Stage Liver Disease (MELD) system has dramatically increased the number of recipients requiring pretransplant renal replacement therapy (RRT) prior to liver transplantation (LT). Factors affecting post-LT outcomes and the need for intraoperative RRT (IORRT) were analyzed in 500 consecutive recipients receiving pretransplant RRT, including comparisons among recipients not receiving IORRT (No-IORRT, n = 401), receiving planned IORRT (Pl-IORRT, n = 70), and receiving emergent, unplanned RRT after LT initiation (Em-IORRT, n = 29). Despite a median MELD of 39, overall 30-day, 1-, 3- and 5-year survivals were 93%, 75%, 68% and 65%, respectively. Em-IORRT recipients had significantly more intraoperative complications (arrhythmias, postreperfusion syndrome, coagulopathy) compared with both No-IORRT and Pl-IORRT and greater 30-day graft loss (28% vs. 10%, p = 0.004) and need for retransplantation (24% vs. 10%, p = 0.099) compared with No-IORRT. A risk score based on multivariate predictors of IORRT accurately identified recipients with chronic (sensitivity 84%, specificity 72%, concordance-statistic [c-statistic] 0.829) and acute (sensitivity 93%, specificity 61%, c-statistic 0.776) liver failure requiring IORRT. In this largest experience of LT in recipients receiving RRT, we report excellent survival and propose a practical model that accurately identifies recipients who may benefit from IORRT. For this select group, timely initiation of IORRT reduces intraoperative complications and improves posttransplant outcomes. © Copyright 2014 The American Society of Transplantation and the American Society of Transplant Surgeons.

  19. Low-Cost GNSS Receivers for Local Monitoring: Experimental Simulation, and Analysis of Displacements.

    Science.gov (United States)

    Biagi, Ludovico; Grec, Florin Cătălin; Negretti, Marco

    2016-12-15

    The geodetic monitoring of local displacements and deformations is often needed for civil engineering structures and natural phenomena like, for example, landslides. A local permanent GNSS (Global Navigation Satellite Systems) network can be installed: receiver positions in the interest area are estimated and monitored with respect to reference stations. Usually, GNSS geodetic receivers are adopted and provide results with accuracies at the millimeter level: however, they are very expensive and the initial cost and the risk of damage and loss can discourage this approach. In this paper the accuracy and the reliability of low-cost u-blox GNSS receivers are experimentally investigated for local monitoring. Two experiments are analyzed. In the first, a baseline (65 m long) between one geodetic reference receiver and one u-blox is continuously observed for one week: the data are processed by hourly sessions and the results provide comparisons between two processing packages and a preliminary accuracy assessment. Then, a network composed of one geodetic and two u-blox receivers is set up. One u-blox is installed on a device (slide) that allows to apply controlled displacements. The geodetic and the other u-blox (at about 130 m) act as references. The experiment lasts about two weeks. The data are again processed by hourly sessions. The estimated displacements of the u-blox on the slide are analyzed and compared with the imposed displacements. All of the results are encouraging: in the first experiment the standard deviations of the residuals are smaller than 5 mm both in the horizontal and vertical; in the second, they are slightly worse but still satisfactory (5 mm in the horizontal and 13 mm in vertical) and the imposed displacements are almost correctly identified.

  20. Analytical analysis of the temporal asymmetry between seawater intrusion and retreat

    Science.gov (United States)

    Rathore, Saubhagya Singh; Zhao, Yue; Lu, Chunhui; Luo, Jian

    2018-01-01

    The quantification of timescales associated with the movement of the seawater-freshwater interface is useful for developing effective management strategies for controlling seawater intrusion (SWI). In this study, for the first time, we derive an explicit analytical solution for the timescales of SWI and seawater retreat (SWR) in a confined, homogeneous coastal aquifer system under the quasi-steady assumption, based on a classical sharp-interface solution for approximating freshwater outflow rates into the sea. The flow continuity and hydrostatic equilibrium across the interface are identified as two primary mechanisms governing timescales of the interface movement driven by an abrupt change in discharge rates or hydraulic heads at the inland boundary. Through theoretical analysis, we quantified the dependence of interface-movement timescales on porosity, hydraulic conductivity, aquifer thickness, aquifer length, density ratio, and boundary conditions. Predictions from the analytical solution closely agreed with those from numerical simulations. In addition, we define a temporal asymmetry index (the ratio of the SWI timescale to the SWR timescale) to represent the resilience of the coastal aquifer in response to SWI. The developed analytical solutions provide a simple tool for the quick assessment of SWI and SWR timescales and reveal that the temporal asymmetry between SWI and SWR mainly relies on the initial and final values of the freshwater flux at the inland boundary, and is weakly affected by aquifer parameters. Furthermore, we theoretically examined the log-linearity relationship between the timescale and the freshwater flux at the inland boundary, and found that the relationship may be approximated by two linear functions with a slope of -2 and -1 for large changes at the boundary flux for SWI and SWR, respectively.

  1. Analytical chemistry

    International Nuclear Information System (INIS)

    Choi, Jae Seong

    1993-02-01

    This book is comprised of nineteen chapters, which describes introduction of analytical chemistry, experimental error and statistics, chemistry equilibrium and solubility, gravimetric analysis with mechanism of precipitation, range and calculation of the result, volume analysis on general principle, sedimentation method on types and titration curve, acid base balance, acid base titration curve, complex and firing reaction, introduction of chemical electro analysis, acid-base titration curve, electrode and potentiometry, electrolysis and conductometry, voltammetry and polarographic spectrophotometry, atomic spectrometry, solvent extraction, chromatograph and experiments.

  2. An analytic analysis of the pion decay constant in three-flavoured chiral perturbation theory

    International Nuclear Information System (INIS)

    Ananthanarayan, B.; Ghosh, Shayan; Bijnens, Johan

    2017-01-01

    A representation of the two-loop contribution to the pion decay constant in SU(3) chiral perturbation theory is presented. The result is analytic up to the contribution of the three (different) mass sunset integrals, for which an expansion in their external momentum has been taken. We also give an analytic expression for the two-loop contribution to the pion mass based on a renormalized representation and in terms of the physical eta mass. We find an expansion of F π and M π 2 in the strange-quark mass in the isospin limit, and we perform the matching of the chiral SU(2) and SU(3) low-energy constants. A numerical analysis demonstrates the high accuracy of our representation, and the strong dependence of the pion decay constant upon the values of the low-energy constants, especially in the chiral limit. Finally, we present a simplified representation that is particularly suitable for fitting with available lattice data. (orig.)

  3. An analysis of beam parameters on proton-acoustic waves through an analytic approach.

    Science.gov (United States)

    Kipergil, Esra Aytac; Erkol, Hakan; Kaya, Serhat; Gulsen, Gultekin; Unlu, Mehmet Burcin

    2017-06-21

    It has been reported that acoustic waves are generated when a high-energy pulsed proton beam is deposited in a small volume within tissue. One possible application of proton-induced acoustics is to get real-time feedback for intra-treatment adjustments by monitoring such acoustic waves. A high spatial resolution in ultrasound imaging may reduce proton range uncertainty. Thus, it is crucial to understand the dependence of the acoustic waves on the proton beam characteristics. In this manuscript, firstly, an analytic solution for the proton-induced acoustic wave is presented to reveal the dependence of the signal on the beam parameters; then it is combined with an analytic approximation of the Bragg curve. The influence of the beam energy, pulse duration and beam diameter variation on the acoustic waveform are investigated. Further analysis is performed regarding the Fourier decomposition of the proton-acoustic signals. Our results show that the smaller spill time of the proton beam upsurges the amplitude of the acoustic wave for a constant number of protons, which is hence beneficial for dose monitoring. The increase in the energy of each individual proton in the beam leads to the spatial broadening of the Bragg curve, which also yields acoustic waves of greater amplitude. The pulse duration and the beam width of the proton beam do not affect the central frequency of the acoustic wave, but they change the amplitude of the spectral components.

  4. Eddy Current Signal Analysis for Transmit-Receive Pancake Coil on ECT Array Probe

    International Nuclear Information System (INIS)

    Lee, Hyang Beom

    2006-01-01

    In this paper, the eddy current signals come from a pair of transmit-receive (T/R) pancake coil on ECT array Probe are analyzed with the variations of the lift-of and of the distance between transmit and receive coils. To obtain the electromagnetic characteristics of the probes, the governing equation describing the eddy current problems is derived from Maxwell's equation and is solved using three-dimensional finite element method. Eddy current signals from T/R coils on ECT array probe have quite different characteristics compared with ones from impedance coil on rotating pancake coil probe. The results in this paper ran be helpful when the field eddy current signals from ECT array probe are evaluated

  5. Heat Transfer Analysis and Modeling of a Parabolic Trough Solar Receiver Implemented in Engineering Equation Solver

    Energy Technology Data Exchange (ETDEWEB)

    Forristall, R.

    2003-10-01

    This report describes the development, validation, and use of a heat transfer model implemented in Engineering Equation Solver. The model determines the performance of a parabolic trough solar collector's linear receiver, also called a heat collector element. All heat transfer and thermodynamic equations, optical properties, and parameters used in the model are discussed. The modeling assumptions and limitations are also discussed, along with recommendations for model improvement.

  6. GPS receiver phase biases estimable in PPP-RTK networks: dynamic characterization and impact analysis

    Science.gov (United States)

    Zhang, Baocheng; Liu, Teng; Yuan, Yunbin

    2017-11-01

    The integer ambiguity resolution enabled precise point positioning (PPP-RTK) has been proven advantageous in a wide range of applications. The realization of PPP-RTK concerns the isolation of satellite phase biases (SPBs) and other corrections from a network of Global Positioning System (GPS) reference receivers. This is generally based on Kalman filter in order to achieve real-time capability, in which proper modeling of the dynamics of various types of unknowns remains crucial. This paper seeks to gain insight into how to reasonably deal with the dynamic behavior of the estimable receiver phase biases (RPBs). Using dual-frequency GPS data collected at six colocated receivers over days 50-120 of 2015, we analyze the 30-s epoch-by-epoch estimates of L1 and wide-lane (WL) RPBs for each receiver pair. The dynamics observed in these estimates are a combined effect of three factors, namely the random measurement noise, the multipath and the ambient temperature. The first factor can be overcome by turning to a real-time filter and the second by considering the use of a sidereal filtering. The third factor has an effect only on the WL, and this effect appears to be linear. After accounting for these three factors, the low-pass-filtered, sidereal-filtered, epoch-by-epoch estimates of L1 RPBs follow a random walk process, whereas those of WL RPBs are constant over time. Properly modeling the dynamics of RPBs is vital, as it ensures the best convergence of the Kalman-filtered, between-satellite single-differenced SPB estimates to their correct values and, in turn, shortens the time-to-first-fix at user side.

  7. Thermodynamic analysis of an organic rankine cycle using a tubular solar cavity receiver

    International Nuclear Information System (INIS)

    Loni, R.; Kasaeian, A.B.; Mahian, O.; Sahin, A.Z.

    2016-01-01

    Highlights: • A non-regenerative Organic Rankine Cycle has been analyzed. • R113, R601, R11, R141b, Ethanol and Methanol were used as the working fluid. • A parabolic dish concentrator with a square prismatic cavity receiver was used. • Thermal efficiency, second law efficiency, and net power output were analyzed. - Abstract: In this study, a non-regenerative Organic Rankine Cycle (ORC) has been thermodynamically analyzed under superheated conditions, constant evaporator pressure of 2.5 MPa, and condenser temperature of 300 K. R113, R601, R11, R141b, Ethanol and Methanol were employed as the working fluid. A parabolic dish concentrator with a square prismatic tubular cavity receiver was used as the heat source of the ORC system. The effects of the tube diameter, the cavity depth, and the solar irradiation on the thermodynamic performance of the selected working fluid were investigated. Some thermodynamic parameters were analyzed in this study. These thermodynamic parameters included the thermal efficiency, second law efficiency, total irreversibility, availability ratio, mass flow rate, and net power output. The results showed that, among the selected working fluids, methanol had the highest thermal efficiency, net power output, second law efficiency, and availability ratio in the range of turbine inlet temperature (TIT) considered. On the other hand, methanol had the smallest total irreversibility in the same range of TIT. The results showed also that mass flow rate and consequently the net power output increased for higher solar irradiation, smaller tube diameter, and for the case of cubical cavity receiver (i.e. cavity depth h equal to the receiver aperture side length a).

  8. Combining ray tracing and CFD in the thermal analysis of a parabolic dish tubular cavity receiver

    Science.gov (United States)

    Craig, Ken J.; Marsberg, Justin; Meyer, Josua P.

    2016-05-01

    This paper describes the numerical evaluation of a tubular receiver used in a dish Brayton cycle. In previous work considering the use of Computational Fluid Dynamics (CFD) to perform the calculation of the absorbed radiation from the parabolic dish into the cavity as well as the resulting conjugate heat transfer, it was shown that an axi-symmetric model of the dish and receiver absorbing surfaces was useful in reducing the computational cost required for a full 3-D discrete ordinates solution, but concerns remained about its accuracy. To increase the accuracy, the Monte Carlo ray tracer SolTrace is used to perform the calculation of the absorbed radiation profile to be used in the conjugate heat transfer CFD simulation. The paper describes an approach for incorporating a complex geometry like a tubular receiver generated using CFD software into SolTrace. The results illustrate the variation of CFD mesh density that translates into the number of elements in SolTrace as well as the number of rays used in the Monte Carlo approach and their effect on obtaining a resolution-independent solution. The conjugate heat transfer CFD simulation illustrates the effect of applying the SolTrace surface heat flux profile solution as a volumetric heat source to heat up the air inside the tube. Heat losses due to convection and thermal re-radiation are also determined as a function of different tube absorptivities.

  9. Analytics for Education

    Science.gov (United States)

    MacNeill, Sheila; Campbell, Lorna M.; Hawksey, Martin

    2014-01-01

    This article presents an overview of the development and use of analytics in the context of education. Using Buckingham Shum's three levels of analytics, the authors present a critical analysis of current developments in the domain of learning analytics, and contrast the potential value of analytics research and development with real world…

  10. Heat transfer analysis of porous media receiver with different transport and thermophysical models using mixture as feeding gas

    International Nuclear Information System (INIS)

    Wang, Fuqiang; Tan, Jianyu; Wang, Zhiqiang

    2014-01-01

    Highlights: • Using local thermal non-equilibrium model to solve heat transfer of porous media. • CH 4 /H 2 O mixture is adopted as feeding gas of porous media receiver. • Radiative transfer equation between porous strut is solved by Rosseland approximation. • Transport and thermophysical models not included in Fluent are programmed by UDFs. • Variations of model on thermal performance of porous media receiver are studied. - Abstract: The local thermal non-equilibrium model is adopted to solve the steady state heat and mass transfer problems of porous media solar receiver. The fluid entrance surface is subjected to concentrated solar radiation, and CH 4 /H 2 O mixture is adopted as feeding gas. The radiative heat transfer equation between porous strut is solved by Rosseland approximation. The impacts of variation in transport and thermophysical characteristics model of gas mixture on thermal performance of porous media receiver are investigated. The transport and thermophysical characteristics models which are not included in software Fluent are programmed by user defined functions (UDFs). The numerical results indicate that models of momentum source term for porous media receiver have significant impact on pressure drop and static pressure distribution, and the radiative heat transfer cannot be omitted during the thermal performance analysis of porous media receiver

  11. Remote access methods for exploratory data analysis and statistical modelling: Privacy-Preserving Analytics.

    Science.gov (United States)

    Sparks, Ross; Carter, Chris; Donnelly, John B; O'Keefe, Christine M; Duncan, Jodie; Keighley, Tim; McAullay, Damien

    2008-09-01

    This paper is concerned with the challenge of enabling the use of confidential or private data for research and policy analysis, while protecting confidentiality and privacy by reducing the risk of disclosure of sensitive information. Traditional solutions to the problem of reducing disclosure risk include releasing de-identified data and modifying data before release. In this paper we discuss the alternative approach of using a remote analysis server which does not enable any data release, but instead is designed to deliver useful results of user-specified statistical analyses with a low risk of disclosure. The techniques described in this paper enable a user to conduct a wide range of methods in exploratory data analysis, regression and survival analysis, while at the same time reducing the risk that the user can read or infer any individual record attribute value. We illustrate our methods with examples from biostatistics using publicly available data. We have implemented our techniques into a software demonstrator called Privacy-Preserving Analytics (PPA), via a web-based interface to the R software. We believe that PPA may provide an effective balance between the competing goals of providing useful information and reducing disclosure risk in some situations.

  12. The Analytical Instrumentarium for Predictive Analysis of Revenue from the Sale of Goods

    Directory of Open Access Journals (Sweden)

    Nosach Nataliia M.

    2017-12-01

    Full Text Available The article is aimed at elaborating recommendations on the selection of analytical instrumentarium for predictive analysis of revenue from the sale of goods, according to the nature of its seasonal changes. The necessity of carrying out predictive analysis of revenue from the sale of goods as an important component of its management is substantiated. The attention is focused on the necessity to use for predictive analysis of revenue from the sale of goods the trend-seasonal models which take into consideration both regularity and randomness of formation of values of levels of the series. A structural-logical model of technology of predictive analysis of revenue from the sale of goods has been proposed according to the nature of its seasonal changes. A number of criteria has been defined, which allow to reveal in a series of dynamics the presence of anomalous data, trend, and seasonal fluctuations. The iterative method of distribution of series of dynamics of revenue from the sale of goods by components has been tested. The recommendations on the choice of the trend model, which can be used to construct both point and interval predictions of the volume of proceeds from sale of goods, are provided.

  13. Cytobank: providing an analytics platform for community cytometry data analysis and collaboration.

    Science.gov (United States)

    Chen, Tiffany J; Kotecha, Nikesh

    2014-01-01

    Cytometry is used extensively in clinical and laboratory settings to diagnose and track cell subsets in blood and tissue. High-throughput, single-cell approaches leveraging cytometry are developed and applied in the computational and systems biology communities by researchers, who seek to improve the diagnosis of human diseases, map the structures of cell signaling networks, and identify new cell types. Data analysis and management present a bottleneck in the flow of knowledge from bench to clinic. Multi-parameter flow and mass cytometry enable identification of signaling profiles of patient cell samples. Currently, this process is manual, requiring hours of work to summarize multi-dimensional data and translate these data for input into other analysis programs. In addition, the increase in the number and size of collaborative cytometry studies as well as the computational complexity of analytical tools require the ability to assemble sufficient and appropriately configured computing capacity on demand. There is a critical need for platforms that can be used by both clinical and basic researchers who routinely rely on cytometry. Recent advances provide a unique opportunity to facilitate collaboration and analysis and management of cytometry data. Specifically, advances in cloud computing and virtualization are enabling efficient use of large computing resources for analysis and backup. An example is Cytobank, a platform that allows researchers to annotate, analyze, and share results along with the underlying single-cell data.

  14. Optimum shape design of incompressible hyperelastic structures with analytical sensitivity analysis

    Energy Technology Data Exchange (ETDEWEB)

    Jarraya, A.; Wali, M.; Dammark, F. [University of Sfax, Sfax (Turkey)

    2014-08-15

    This paper is focused on the structural shape optimization of incompressible hyperelastic structures. An analytical sensitivity is developed for the rubber like materials. The whole shape optimization process is carried out by coupling a closed geometric shape in R{sup 2} with boundaries, defined by B-splines curves, exact sensitivity analysis and mathematical programming method (S.Q.P: sequential quadratic programming). Design variables are the control points coordinate. The objective function is to minimize Von-Mises stress, constrained to the total material volume of the structure remains constant. In order to validate the exact Jacobian method, the sensitivity calculation is performed: numerically by an efficient finite difference scheme and by the exact Jacobian method. Numerical optimization examples are presented for elastic and hyperelastic materials using the proposed method.

  15. Analytical methods for analysis of neutron cross sections of amino acids and proteins

    Energy Technology Data Exchange (ETDEWEB)

    Voi, Dante L.; Ferreira, Francisco de O.; Nunes, Rogerio Chaffin; Carvalheira, Luciana, E-mail: dante@ien.gov.br, E-mail: fferreira@ien.gov.br, E-mail: Chaffin@ien.gov.br, E-mail: luciana@ien.gov.br [Instituto de Engenharia Nuclear (IEN/CNEN-RJ), Rio de Janeiro, RJ (Brazil); Rocha, Hélio F. da, E-mail: helionutro@gmail.com.br [Universidade Federal do Rio de Janeiro (IPPMG/UFRJ), Rio de Janeiro, RJ (Brazil). Instituto de Pediatria

    2017-07-01

    Two unpublished analytical processes were developed at IEN-CNEN-RJ for the analysis of neutron cross sections of chemical compounds and complex molecules, the method of data parceling and grouping (P and G) and the method of data equivalence and similarity (E and S) of cross-sections. The former allows the division of a complex compound or molecule so that the parts can be manipulated to construct a value of neutron cross section for the compound or the entire molecule. The second method allows by comparison obtain values of neutron cross-sections of specific parts of the compound or molecule, as the amino acid radicals or its parts. The processes were tested for the determination of neutron cross-sections of the 20 human amino acids and a small database was built for future use in the construction of neutron cross-sections of proteins and other components of the human being cells, also in other industrial applications. (author)

  16. Analytic analysis of auxetic metamaterials through analogy with rigid link systems

    Science.gov (United States)

    Rayneau-Kirkhope, Daniel; Zhang, Chengzhao; Theran, Louis; Dias, Marcelo A.

    2018-02-01

    In recent years, many structural motifs have been designed with the aim of creating auxetic metamaterials. One area of particular interest in this subject is the creation of auxetic material properties through elastic instability. Such metamaterials switch from conventional behaviour to an auxetic response for loads greater than some threshold value. This paper develops a novel methodology in the analysis of auxetic metamaterials which exhibit elastic instability through analogy with rigid link lattice systems. The results of our analytic approach are confirmed by finite-element simulations for both the onset of elastic instability and post-buckling behaviour including Poisson's ratio. The method gives insight into the relationships between mechanisms within lattices and their mechanical behaviour; as such, it has the potential to allow existing knowledge of rigid link lattices with auxetic paths to be used in the design of future buckling-induced auxetic metamaterials.

  17. Investigation of different types of filters for atmospheric trace elements analysis by three analytical techniques

    International Nuclear Information System (INIS)

    Ali, A.E.; Bacso, J.

    1996-01-01

    Different atmospheric aerosol samples were collected on three types of filters. Disks of both loaded and clean areas of each kind of filter were investigated by XRF, PIXE and Scanning Electron Microscope (SEM) methods. The blank concentration values of the elements Al, Si, P, S, Cl, K, Ca, Sc, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Br and Pb in the three types of filters are discussed. It is found that for trace elemental analysis, the Nuclepore membrane filters are the most suitable for sampling. These have much lower blank element concentration values than the glass fibres and ash free filters. It was found also that the PIXE method is a more reliable analytical technique for atmospheric aerosol particles than the other methods. (author). 20 refs., 3 figs., 3 tabs

  18. Analytical methods for analysis of neutron cross sections of amino acids and proteins

    International Nuclear Information System (INIS)

    Voi, Dante L.; Ferreira, Francisco de O.; Nunes, Rogerio Chaffin; Carvalheira, Luciana; Rocha, Hélio F. da

    2017-01-01

    Two unpublished analytical processes were developed at IEN-CNEN-RJ for the analysis of neutron cross sections of chemical compounds and complex molecules, the method of data parceling and grouping (P and G) and the method of data equivalence and similarity (E and S) of cross-sections. The former allows the division of a complex compound or molecule so that the parts can be manipulated to construct a value of neutron cross section for the compound or the entire molecule. The second method allows by comparison obtain values of neutron cross-sections of specific parts of the compound or molecule, as the amino acid radicals or its parts. The processes were tested for the determination of neutron cross-sections of the 20 human amino acids and a small database was built for future use in the construction of neutron cross-sections of proteins and other components of the human being cells, also in other industrial applications. (author)

  19. A guide to genome-wide association analysis and post-analytic interrogation.

    Science.gov (United States)

    Reed, Eric; Nunez, Sara; Kulp, David; Qian, Jing; Reilly, Muredach P; Foulkes, Andrea S

    2015-12-10

    This tutorial is a learning resource that outlines the basic process and provides specific software tools for implementing a complete genome-wide association analysis. Approaches to post-analytic visualization and interrogation of potentially novel findings are also presented. Applications are illustrated using the free and open-source R statistical computing and graphics software environment, Bioconductor software for bioinformatics and the UCSC Genome Browser. Complete genome-wide association data on 1401 individuals across 861,473 typed single nucleotide polymorphisms from the PennCATH study of coronary artery disease are used for illustration. All data and code, as well as additional instructional resources, are publicly available through the Open Resources in Statistical Genomics project: http://www.stat-gen.org. © 2015 The Authors. Statistics in Medicine Published by John Wiley & Sons Ltd.

  20. Optimum shape design of incompressible hyperelastic structures with analytical sensitivity analysis

    International Nuclear Information System (INIS)

    Jarraya, A.; Wali, M.; Dammark, F.

    2014-01-01

    This paper is focused on the structural shape optimization of incompressible hyperelastic structures. An analytical sensitivity is developed for the rubber like materials. The whole shape optimization process is carried out by coupling a closed geometric shape in R 2 with boundaries, defined by B-splines curves, exact sensitivity analysis and mathematical programming method (S.Q.P: sequential quadratic programming). Design variables are the control points coordinate. The objective function is to minimize Von-Mises stress, constrained to the total material volume of the structure remains constant. In order to validate the exact Jacobian method, the sensitivity calculation is performed: numerically by an efficient finite difference scheme and by the exact Jacobian method. Numerical optimization examples are presented for elastic and hyperelastic materials using the proposed method.

  1. Analytic Bayesian solution of the two-stage poisson-type problem in probabilistic risk analysis

    International Nuclear Information System (INIS)

    Frohner, F.H.

    1985-01-01

    The basic purpose of probabilistic risk analysis is to make inferences about the probabilities of various postulated events, with an account of all relevant information such as prior knowledge and operating experience with the specific system under study, as well as experience with other similar systems. Estimation of the failure rate of a Poisson-type system leads to an especially simple Bayesian solution in closed form if the prior probabilty implied by the invariance properties of the problem is properly taken into account. This basic simplicity persists if a more realistic prior, representing order of magnitude knowledge of the rate parameter, is employed instead. Moreover, the more realistic prior allows direct incorporation of experience gained from other similar systems, without need to postulate a statistical model for an underlying ensemble. The analytic formalism is applied to actual nuclear reactor data

  2. Receiver functions analysis in Northern Tanzania to understand the earliest stage of rifting

    Science.gov (United States)

    Tiberi, C.; Albaric, J.; Deschamps, A.; Deverchere, J.; Ebinger, C. J.; Ferdinand, R. W.; Gautier, S.; Lambert, C.; Msabi, M.; Mtelela, K.; Muzuka, A.; Perrot, J.; Rasendra, N.; Roecker, S. W.; Rodzianko, A.; Witkin, E.

    2013-12-01

    The East African Rift (EAR) is the site of stretching and breakup of the lithosphere in response to a combination of regional pulling forces and mantle upwellings. Deformation results from complex interactions between magmatic intrusions, faulting, asthenospheric dynamism and far field stresses. It thus involves both deep processes and local inherited fabrics. In the frame of two international projects CRAFTI (NSF) and CoLiBrEA (ANR), we gather our skills to lead a multidisciplinary project in order to characterize the factors involved in continental rifting. We target the first 5 My of a magmatic rift initiating in thick (>150 km) continental lithosphere, where we can directly image and detect fault and magma interactions, the role of inherited and rheological heterogeneities of the lithosphere on rift localisation. We deployed 35 broadband seismic stations in Natron and Ngorongoro areas in January 2013 to characterize crustal and mantle structures of the rift. The stations were equipped by 3 component sensors and Reftek Recorders to continuously record teleseisms as well as local seismicity. We present here a receiver function analyse on the teleseismic events recorded during the first 6 months of the experiment. Both P- and S-waves receiver functions were proceeded to document the modification of the crust and the mantle due to plate stretching and magmatic processes. The Vp/Vs ratio informs on the state of the crust, which is affected by magmatic and fluids intrusions at different depths. The S-wave receiver function gives insight into the lithosphere state and the nature of the mantle beneath the rift (archean or plume affected).

  3. Receiver function analysis and preliminary body wave tomography of the MACOMO network in Madagascar

    Science.gov (United States)

    Pratt, M. J.; Wysession, M. E.; Wiens, D. A.; Nyblade, A.; Aleqabi, G. I.; Shore, P.; Rambolamana, G.; Sy Tanjona Andriampenomanana ny Ony, F.; Rakotondraibe, T.

    2013-12-01

    We present results from a set of seismological studies of the continental island of Madagascar using new seismic data from the NSF-funded MACOMO (MAdagascar, COmores, and MOzambique) IRIS PASSCAL broadband seismometer array. MACOMO involved the deployment during 2011-2013 of 26 broadband seismometers in Madagascar and 6 seismometers in Mozambique, providing the first seismic imaging across the world's 4th-largest island. We present preliminary crustal structure variations from receiver function analyses and body wave tomography results. We calculate radial receiver functions for all Madagascar stations and use the weighted linear regression methodology of Herrmann and Ammon [2002] to invert for shear velocity. Upper mantle and crustal structures from the receiver function analyses are used to help determine starting models for the teleseismic travel-time tomography. The tectonic structure of Madagascar is generally divided into four crustal blocks. Initial seismic imaging shows that the Archean Antongil block that runs along the east of the island has the thickest crust (>40 km) and three Proterozoic terranes that make up the central highlands and are bounded by fault and shear zones are closer to the average crustal thickness (35 km). There has been late Cenozoic intraplate volcanism in northern and central Madagascar (as recently as 1 million years ago), and different hypotheses for its origin will be evaluated by the preliminary results from the three different seismic studies. Complete analyses will be done incorporating seismic data from simultaneous and complementary array of both land- and ocean-based seismometers from French and German deployments.

  4. Exact capture probability analysis of GSC receivers over i.n.d. Rayleigh fading channels

    KAUST Repository

    Nam, Sungsik

    2013-07-01

    A closed-form expression of the capture probability of generalized selection combining (GSC) RAKE receivers was introduced in [1]. The idea behind this new performance metric is to quantify how the remaining set of uncombined paths affects the overall performance both in terms of loss in power and increase in interference levels. In this previous work, the assumption was made that the fading is both independent and identically distributed from path to path. However, the average strength of each path is different in reality. In order to derive a closed-form expression of the capture probability over independent and non-identically distributed (i.n.d.) fading channels, we need to derive the joint statistics of ordered non-identical exponential variates. With this motivation in mind, we first provide in this paper some new order statistics results in terms of both moment generating function (MGF) and probability density function (PDF) expressions under an i.n.d. assumption and then derive a new exact closed-form expression for the capture probability GSC RAKE receivers in this more realistic scenario. © 2013 IEEE.

  5. Shallow Sedimentary Structure of the Brahmaputra Valley Constraint from Receiver Functions Analysis

    Science.gov (United States)

    Saikia, Sowrav; Chopra, Sumer; Baruah, Santanu; Singh, Upendra K.

    2017-01-01

    In this study, receiver functions from ten Broadband seismograph stations on Cenozoic sediment formations of Brahmaputra valley and its neighboring region in northeastern part of India are determined. Receiver function traces from this region show delay in peak by 1-2.5 s and associated minor peaks with the direct P-phase peak. Based on such observation, we try to image sedimentary structure of the Brahmaputra valley plain, adjacent Shillong plateau and Himalayan foredeep region. An adapted hybrid global waveform inversion technique has been applied to extract sedimentary basin structure beneath each site. The sedimentary cover of the basin is about 0.5-6.5 km thick across the valley, 0.5-1.0 km on Shillong plateau and 2.0-5.0 km in nearby foredeep region. We have found that sedimentary thickness increases from SW to NE along the Brahmaputra valley and towards the Eastern Himalayan syntaxes. The estimated sediment thickness and S wave velocity structure agree well with the results of previous active source, gravity, and deep borehole studies carried out in this region. The thick crustal low velocity sediment cover in Brahmaputra valley is expected to amplify ground motions during earthquakes and therefore important for seismic hazard assessment of the region.

  6. Efficiency of analytical methodologies in uncertainty analysis of seismic core damage frequency

    International Nuclear Information System (INIS)

    Kawaguchi, Kenji; Uchiyama, Tomoaki; Muramatsu, Ken

    2012-01-01

    Fault Tree and Event Tree analysis is almost exclusively relied upon in the assessments of seismic Core Damage Frequency (CDF). In this approach, Direct Quantification of Fault tree using Monte Carlo simulation (DQFM) method, or simply called Monte Carlo (MC) method, and Binary Decision Diagram (BDD) method were introduced as alternatives for a traditional approximation method, namely Minimal Cut Set (MCS) method. However, there is still no agreement as to which method should be used in a risk assessment of seismic CDF, especially for uncertainty analysis. The purpose of this study is to examine the efficiencies of the three methods in uncertainty analysis as well as in point estimation so that the decision of selecting a proper method can be made effectively. The results show that the most efficient method would be BDD method in terms of accuracy and computational time. However, it will be discussed that BDD method is not always applicable to PSA models while MC method is so in theory. In turn, MC method was confirmed to agree with the exact solution obtained by BDD method, but it took a large amount of time, in particular for uncertainty analysis. On the other hand, it was shown that the approximation error of MCS method may not be as bad in uncertainty analysis as it is in point estimation. Based on these results and previous works, this paper will propose a scheme to select an appropriate analytical method for a seismic PSA study. Throughout this study, SECOM2-DQFM code was expanded to be able to utilize BDD method and to conduct uncertainty analysis with both MC and BDD method. (author)

  7. Video Analytics

    DEFF Research Database (Denmark)

    Nasrollahi, Kamal; Distante, Cosimo; Hua, Gang

    2017-01-01

    This book collects the papers presented at two workshops during the 23rd International Conference on Pattern Recognition (ICPR): the Third Workshop on Video Analytics for Audience Measurement (VAAM) and the Second International Workshop on Face and Facial Expression Recognition (FFER) from Real...... World Videos. The workshops were run on December 4, 2016, in Cancun in Mexico. The two workshops together received 13 papers. Each paper was then reviewed by at least two expert reviewers in the field. In all, 11 papers were accepted to be presented at the workshops. The topics covered in the papers...

  8. Video Analytics

    DEFF Research Database (Denmark)

    This book collects the papers presented at two workshops during the 23rd International Conference on Pattern Recognition (ICPR): the Third Workshop on Video Analytics for Audience Measurement (VAAM) and the Second International Workshop on Face and Facial Expression Recognition (FFER) from Real...... World Videos. The workshops were run on December 4, 2016, in Cancun in Mexico. The two workshops together received 13 papers. Each paper was then reviewed by at least two expert reviewers in the field. In all, 11 papers were accepted to be presented at the workshops. The topics covered in the papers...

  9. The Analytic Onion: Examining Training Issues from Different Levels of Analysis. Interim Technical Paper for Period July 1989-June 1991.

    Science.gov (United States)

    Lamb, Theodore A.; Chin, Keric B. O.

    This paper proposes a conceptual framework based on different levels of analysis using the metaphor of the layers of an onion to help organize and structure thinking on research issues concerning training. It discusses the core of the "analytic onion," the biological level, and seven levels of analysis that surround that core: the individual, the…

  10. Cost-Utility Analysis of Bariatric Surgery in Italy: Results of Decision-Analytic Modelling

    Directory of Open Access Journals (Sweden)

    Marcello Lucchese

    2017-06-01

    Full Text Available Objective: To evaluate the cost-effectiveness of bariatric surgery in Italy from a third-party payer perspective over a medium-term (10 years and a long-term (lifetime horizon. Methods: A state-transition Markov model was developed, in which patients may experience surgery, post-surgery complications, diabetes mellitus type 2, cardiovascular diseases or die. Transition probabilities, costs, and utilities were obtained from the Italian and international literature. Three types of surgeries were considered: gastric bypass, sleeve gastrectomy, and adjustable gastric banding. A base-case analysis was performed for the population, the characteristics of which were obtained from surgery candidates in Italy. Results: In the base-case analysis, over 10 years, bariatric surgery led to cost increment of EUR 2,661 and generated additional 1.1 quality-adjusted life years (QALYs. Over a lifetime, surgery led to savings of EUR 8,649, additional 0.5 life years and 3.2 QALYs. Bariatric surgery was cost-effective at 10 years with an incremental cost-effectiveness ratio of EUR 2,412/QALY and dominant over conservative management over a lifetime. Conclusion: In a comprehensive decision analytic model, a current mix of surgical methods for bariatric surgery was cost-effective at 10 years and cost-saving over the lifetime of the Italian patient cohort considered in this analysis.

  11. Cost-Utility Analysis of Bariatric Surgery in Italy: Results of Decision-Analytic Modelling.

    Science.gov (United States)

    Lucchese, Marcello; Borisenko, Oleg; Mantovani, Lorenzo Giovanni; Cortesi, Paolo Angelo; Cesana, Giancarlo; Adam, Daniel; Burdukova, Elisabeth; Lukyanov, Vasily; Di Lorenzo, Nicola

    2017-01-01

    To evaluate the cost-effectiveness of bariatric surgery in Italy from a third-party payer perspective over a medium-term (10 years) and a long-term (lifetime) horizon. A state-transition Markov model was developed, in which patients may experience surgery, post-surgery complications, diabetes mellitus type 2, cardiovascular diseases or die. Transition probabilities, costs, and utilities were obtained from the Italian and international literature. Three types of surgeries were considered: gastric bypass, sleeve gastrectomy, and adjustable gastric banding. A base-case analysis was performed for the population, the characteristics of which were obtained from surgery candidates in Italy. In the base-case analysis, over 10 years, bariatric surgery led to cost increment of EUR 2,661 and generated additional 1.1 quality-adjusted life years (QALYs). Over a lifetime, surgery led to savings of EUR 8,649, additional 0.5 life years and 3.2 QALYs. Bariatric surgery was cost-effective at 10 years with an incremental cost-effectiveness ratio of EUR 2,412/QALY and dominant over conservative management over a lifetime. In a comprehensive decision analytic model, a current mix of surgical methods for bariatric surgery was cost-effective at 10 years and cost-saving over the lifetime of the Italian patient cohort considered in this analysis. © 2017 The Author(s) Published by S. Karger GmbH, Freiburg.

  12. Descending and ascending trajectories of dialogical analysis: seventh analytic interpretation on the short story "The guerrillero"

    Directory of Open Access Journals (Sweden)

    Danilo Silva Guimarães

    Full Text Available Abstract: The dialogical unity for the analysis of the Self includes the descending intersubjective interpenetration of the psychologist's lens into the self-others' feeling/thinking together with the analytic demonstration concerning the transformations of the objects that participate in the intrapsychological stream of the focused feeling/thinking. The theoretical and methodological issues selected for our present study concern how to make dialogical analysis out of empirical data and how to articulate the analyzed content to the interpretative whole situation from which the researcher and the subject matter are part of. Dialogism does not have a standardized procedure and we are not considering that there is only one correct methodological procedure in dialogical psychology. Nevertheless, discussing some dialogical approaches to a short story from Albalucía Ángel (1979, we found that the starting point for the dialogical analysis should be the mediated relation of the Self with the others, emphasizing the relevance of the extra-verbal concrete situation.

  13. Spine Radiosurgery: A Dosimetric Analysis in 124 Patients Who Received 18 Gy

    International Nuclear Information System (INIS)

    Schipani, Stefano; Wen, Winston; Jin, Jain-Yue; Kim, Jin Koo; Ryu, Samuel

    2012-01-01

    Purpose: To define the safely tolerated doses to organs at risk (OARs) adjacent to the target volume (TV) of spine radiosurgery (SRS) with 18-Gy in a single fraction. Methods and Materials: A total of 124 patient cases with 165 spine metastases were reviewed. An 18-Gy single-fraction regimen was prescribed to the 90% isodose line encompassing the TV. A constraint of 10 Gy to 10% of the spinal cord outlined 6 mm above and below the TV was used. Dosimetric data to OARs were analyzed. Results: A total of 124 patients (100%) were followed-up, and median follow-up time was 7 months (1-50 months). Symptoms and local control were achieved in 114 patients (92%). Acute Radiation Therapy Oncology Group (RTOG) grade 1 oral mucositis occurred in 11 of 11 (100%) patients at risk for oropharyngeal toxicity after cervical spine treatment. There were no RTOG grade 2-4 acute or late complications. Median TV was 43.2 cc (5.3-175.4 cc) and 90% of the TV received median dose of 19 Gy (17-19.8 Gy). Median (range) of spinal cord maximum dose (Dmax), dose to spinal cord 0.35 cc (Dsc0.35), and cord volume receiving 10 Gy (Vsc10) were 13.8 Gy (5.4-21 Gy), 8.9 Gy (2.6-11.4 Gy) and 0.33 cc (0-1.6 cc), respectively. Other OARs were evaluated when in proximity to the TV. Esophagus (n=58), trachea (n=28), oropharynx (n=11), and kidneys (n=34) received median (range) V10 and V15 of 3.1 cc (0-5.8 cc) and 1.2 cc (0-2.9 cc), 2.8 cc (0-4.9 cc), and 0.8 cc (0-2.1 cc), 3.4 cc (0-6.2 cc) and 1.6 cc (0-3.2 cc), 0.3 cc (0-0.8 cc) and 0.08 cc (0-0.1 cc), respectively. Conclusions: Cord Dmax of 14 Gy and D0.35 of 10 Gy are safe dose constraints for 18-Gy single-fraction SRS. Esophagus V10 of 3 cc and V15 of 1 cc, trachea V10 of 3 cc, and V15 of 1 cc, oropharynx V10 of 3.5 cc and V15 of 1.5 cc, kidney V10 of 0.3 cc, and V15 of 0.1 cc are planning guidelines when these OARs are in proximity to the TV.

  14. Receiver function analysis of the crust and upper mantle in Fennoscandia - isostatic implications

    DEFF Research Database (Denmark)

    Frassetto, Andrew; Thybo, Hans

    2013-01-01

    The mountains across southern Norway and other margins of the North Atlantic Ocean appear conspicuously high in the absence of recent convergent tectonics. We investigate this phenomenon with receiver functions calculated for seismometers deployed across southern Fennoscandia. These are used...... to constrain the structure and seismic properties of the lithosphere and primarily to measure the thickness and infer the bulk composition of the crust. Such parameters are key to understanding crustal isostasy and assessing its role, or lack thereof, in supporting the observed elevations. Our study focuses...... on the southern Scandes mountain range that has an average elevation >1.0 km above mean sea level. The crust-mantle boundary (Moho) is ubiquitously imaged, and we occasionally observe structures that may represent the base of the continental lithosphere or other thermal, chemical, or viscous boundaries...

  15. Measurements and Analysis of Secondary User Device Effects on Digital Television Receivers

    Directory of Open Access Journals (Sweden)

    James A. Roberts

    2009-01-01

    Full Text Available This article presents results from a study of the potential effects of secondary users operating in unoccupied television spectrum. Television spectrum is known within the wireless communications community as being underutilized, making it a prime candidate for dynamic spectrum access. The proposed use of this open spectrum has prompted questions concerning the quantity of available channel space that could be used without negative impact on consumers who view digital television broadcasts and the viability of secondary use of open channels immediately adjacent to a digital television broadcast channel. In this work, we investigate secondary device operation in the channels directly adjacent to a desired television channel, and the effects upon a selection of consumer digital television (DTV receivers. Our observations strongly suggest that secondary users could operate “White Space Devices” (WSDs in unoccupied channel bandwidth directly adjacent to a desired digital television (DTV channel, with no observable adverse impact upon the reception of the desired channel content.

  16. Lithosphere structure in Madagascar as revealed from receiver functions and surface waves analysis.

    Science.gov (United States)

    Rindraharisaona, E. J.; Tilmann, F. J.; Yuan, X.; Dreiling, J.; Priestley, K. F.; Barruol, G.; Wysession, M. E.

    2017-12-01

    The geological history of Madagascar makes it an ideal place to study the lithospheric structure and its evolution. It comprises Archean to Proterozoic units on the central eastern part, which is surrounded by a Triassic to Jurassic basin formation in the west and Cretaceous volcanics along the coasts. Quaternary volcanic rocks have been embedded in crystalline and sedimentary rocks. The aim of the present work is to characterize the crustal structure and determine the imprint of the dominant geodynamic events that have affected Madagascar: the Pan-African orogeny, the breakup of Gondwanaland and Neogene tectonic activity. From 2011 to 2014 different temporary seismic arrays were deployed in Madagascar. We based the current study mostly on SELASOMA project, which is composed of 50 seismic stations that were installed traversing southern Madagascar from the west to the east, sampling the different geological units. To measured seismic dispersion curves, one a wide period ranges using ambient noise, Rayleigh and Love surface waves. To compute the average crustal Vp/Vs ratio internal crustal structure and discontinuities in the mantle, we use both P- and S-waves receiver functions. To better resolve of the crustal structure, we jointly inverted P-wave receiver functions and Rayleigh wave group velocity.The crustal extension during the Carboniferous to Cenozoic has thinned the igneous crust down to 15 km in the western Morondava basin by removing much of the lower crust, while the thickness of the upper crust is nearly identical in the sedimentary basin and under Proterozoic and Archaean rocks of the eastern two thirds of Southern Madagascar. In general, the Archean crust is thicker than the Proterozoic, because mafic component is missing in the Proterozoic domain while it forms the bottom of the Archean crust. The lithosphere thickness in the southern part of Madagascar is estimated to be between 90 and 125 km.

  17. Crustal structure of north Peru from analysis of teleseismic receiver functions

    Science.gov (United States)

    Condori, Cristobal; França, George S.; Tavera, Hernando J.; Albuquerque, Diogo F.; Bishop, Brandon T.; Beck, Susan L.

    2017-07-01

    In this study, we present results from teleseismic receiver functions, in order to investigate the crustal thickness and Vp/Vs ratio beneath northern Peru. A total number of 981 receiver functions were analyzed, from data recorded by 28 broadband seismic stations from the Peruvian permanent seismic network, the regional temporary SisNort network and one CTBTO station. The Moho depth and average crustal Vp/Vs ratio were determined at each station using the H-k stacking technique to identify the arrival times of primary P to S conversion and crustal reverberations (PpPms, PpSs + PsPms). The results show that the Moho depth correlates well with the surface topography and varies significantly from west to east, showing a shallow depth of around 25 km near the coast, a maximum depth of 55-60 km beneath the Andean Cordillera, and a depth of 35-40 km further to the east in the Amazonian Basin. The bulk crustal Vp/Vs ratio ranges between 1.60 and 1.88 with the mean of 1.75. Higher values between 1.75 and 1.88 are found beneath the Eastern and Western Cordilleras, consistent with a mafic composition in the lower crust. In contrast values vary from 1.60 to 1.75 in the extreme flanks of the Eastern and Western Cordillera indicating a felsic composition. We find a positive relationship between crustal thickness, Vp/Vs ratio, the Bouguer anomaly, and topography. These results are consistent with previous studies in other parts of Peru (central and southern regions) and provide the first crustal thickness estimates for the high cordillera in northern Peru.

  18. Topological data analysis: A promising big data exploration tool in biology, analytical chemistry and physical chemistry.

    Science.gov (United States)

    Offroy, Marc; Duponchel, Ludovic

    2016-03-03

    An important feature of experimental science is that data of various kinds is being produced at an unprecedented rate. This is mainly due to the development of new instrumental concepts and experimental methodologies. It is also clear that the nature of acquired data is significantly different. Indeed in every areas of science, data take the form of always bigger tables, where all but a few of the columns (i.e. variables) turn out to be irrelevant to the questions of interest, and further that we do not necessary know which coordinates are the interesting ones. Big data in our lab of biology, analytical chemistry or physical chemistry is a future that might be closer than any of us suppose. It is in this sense that new tools have to be developed in order to explore and valorize such data sets. Topological data analysis (TDA) is one of these. It was developed recently by topologists who discovered that topological concept could be useful for data analysis. The main objective of this paper is to answer the question why topology is well suited for the analysis of big data set in many areas and even more efficient than conventional data analysis methods. Raman analysis of single bacteria should be providing a good opportunity to demonstrate the potential of TDA for the exploration of various spectroscopic data sets considering different experimental conditions (with high noise level, with/without spectral preprocessing, with wavelength shift, with different spectral resolution, with missing data). Copyright © 2016 Elsevier B.V. All rights reserved.

  19. Trends in the analytical methods for water analysis; Tendencias de los metodos analiticos para el analisis del agua

    Energy Technology Data Exchange (ETDEWEB)

    Tortajada-Genero, L. A.; Campins-Falco, P. [Universidad de Valencia (Spain)

    2003-07-01

    The technological and methodological advances have provided and evolution of analytical chemistry, specially in the area of water analysis. There area wide variety of problems for this kind of analysis, as result of the high number of possible objectives. They involve from complex environmental studies to routine control of a physical-chemical parameter. Additionally, the variety of analysis to analyse is increasing as in total number as in complexity terms. The response has been the appearance of a high number of analytical methods. Some guidelines and recommendations have been described together with different strategies for quality assurance. In this paper, a review of the last analytical methods described in the scientific references for determinations in water was realised. The evolution and future perspectives were also studied. (Author) 16 refs.

  20. Single Particle-Inductively Coupled Plasma Mass Spectroscopy Analysis of Metallic Nanoparticles in Environmental Samples with Large Dissolved Analyte Fractions.

    Science.gov (United States)

    Schwertfeger, D M; Velicogna, Jessica R; Jesmer, Alexander H; Scroggins, Richard P; Princz, Juliska I

    2016-10-18

    There is an increasing interest to use single particle-inductively coupled plasma mass spectroscopy (SP-ICPMS) to help quantify exposure to engineered nanoparticles, and their transformation products, released into the environment. Hindering the use of this analytical technique for environmental samples is the presence of high levels of dissolved analyte which impedes resolution of the particle signal from the dissolved. While sample dilution is often necessary to achieve the low analyte concentrations necessary for SP-ICPMS analysis, and to reduce the occurrence of matrix effects on the analyte signal, it is used here to also reduce the dissolved signal relative to the particulate, while maintaining a matrix chemistry that promotes particle stability. We propose a simple, systematic dilution series approach where by the first dilution is used to quantify the dissolved analyte, the second is used to optimize the particle signal, and the third is used as an analytical quality control. Using simple suspensions of well characterized Au and Ag nanoparticles spiked with the dissolved analyte form, as well as suspensions of complex environmental media (i.e., extracts from soils previously contaminated with engineered silver nanoparticles), we show how this dilution series technique improves resolution of the particle signal which in turn improves the accuracy of particle counts, quantification of particulate mass and determination of particle size. The technique proposed here is meant to offer a systematic and reproducible approach to the SP-ICPMS analysis of environmental samples and improve the quality and consistency of data generated from this relatively new analytical tool.

  1. Web analytics tools and web metrics tools: An overview and comparative analysis

    OpenAIRE

    Bekavac, Ivan; Garbin Praničević, Daniela

    2015-01-01

    The aim of the paper is to compare and analyze the impact of web analytics tools for measuring the performance of a business model. Accordingly, an overview of web analytics and web metrics tools is given, including their characteristics, main functionalities and available types. The data acquisition approaches and proper choice of web tools for particular business models are also reviewed. The research is divided in two sections. First, a qualitative focus is placed on reviewing web analytic...

  2. Propulsion and launching analysis of variable-mass rockets by analytical methods

    OpenAIRE

    D.D. Ganji; M. Gorji; M. Hatami; A. Hasanpour; N. Khademzadeh

    2013-01-01

    In this study, applications of some analytical methods on nonlinear equation of the launching of a rocket with variable mass are investigated. Differential transformation method (DTM), homotopy perturbation method (HPM) and least square method (LSM) were applied and their results are compared with numerical solution. An excellent agreement with analytical methods and numerical ones is observed in the results and this reveals that analytical methods are effective and convenient. Also a paramet...

  3. Materials of the 3.Poznan analytical meeting: The novel methods of samples preparation and analysis of trace amounts of elements

    International Nuclear Information System (INIS)

    1994-01-01

    The conference on Novel Methods of Samples Preparation and Analysis of Trace Amounts of Elements was the eight of succeeding meetings organized annually since 1985 by the Committee of Analytical Chemistry of the Polish Academy of Sciences. The following groups of topics have been extensively discussed: accuracy and precision in trace amounts analysis, sample preparation methods, certification and application of standards and many other topics important for analytical chemistry of trace amount of different elements. Total 43 lectures have been presented in the course of meeting

  4. Analysis of those national analytic epidemiological studies that by obtention the exposure-response functions

    International Nuclear Information System (INIS)

    Molina, E.; Meneses, E.

    2003-01-01

    The Impact Pathway methodology, developed in the frame of Extern E project for estimating of the external costs or externalities of the energy use, has as one of their main steps the health impact evaluation. This evaluation is carried out through exposure-response functions. In previous estimates of the external costs of power generation in Cuba, functions obtained in international studies were used. The main objective of this work was to carry out a summarized critical analysis of those national analytic epidemiological studies that, according the exposed methodology, consider the main aspects specialized with views to the possible preliminary proposal of functions exposure-response (FER) based own in epidemiologic evidences. In agreement with the analysis, the results show that the great majority of the studies are not useful for the FER establishment, at least in their present form. A minority studies exists that contributes limited evidence and their reanalysis could increase their contribution to the propose purpose. Finally the main problems found in the studies are enumerated revision object

  5. Selection of infectious medical waste disposal firms by using the analytic hierarchy process and sensitivity analysis

    International Nuclear Information System (INIS)

    Hsu, P.-F.; Wu, C.-R.; Li, Y.-T.

    2008-01-01

    While Taiwanese hospitals dispose of large amounts of medical waste to ensure sanitation and personal hygiene, doing so inefficiently creates potential environmental hazards and increases operational expenses. However, hospitals lack objective criteria to select the most appropriate waste disposal firm and evaluate its performance, instead relying on their own subjective judgment and previous experiences. Therefore, this work presents an analytic hierarchy process (AHP) method to objectively select medical waste disposal firms based on the results of interviews with experts in the field, thus reducing overhead costs and enhancing medical waste management. An appropriate weight criterion based on AHP is derived to assess the effectiveness of medical waste disposal firms. The proposed AHP-based method offers a more efficient and precise means of selecting medical waste firms than subjective assessment methods do, thus reducing the potential risks for hospitals. Analysis results indicate that the medical sector selects the most appropriate infectious medical waste disposal firm based on the following rank: matching degree, contractor's qualifications, contractor's service capability, contractor's equipment and economic factors. By providing hospitals with an effective means of evaluating medical waste disposal firms, the proposed AHP method can reduce overhead costs and enable medical waste management to understand the market demand in the health sector. Moreover, performed through use of Expert Choice software, sensitivity analysis can survey the criterion weight of the degree of influence with an alternative hierarchy

  6. Analytical Strategies to Disclose Repeated Consumption of New Psychoactive Substances by Hair Analysis.

    Science.gov (United States)

    Rotolo, Maria C; Klein, Julia; Pacifici, Roberta; Busardo, Francesco Paolo; Pichini, Simona; Marchei, Emilia

    2017-01-01

    New psychoactive substances (NPS) are a heterogenic group of substances with different chemical structures and psychotropic effects. Many pharmacotoxicological laboratories performing drug testing in conventional and nonconventional biological matrices for clinical and forensic purposes do not include screening procedures for NPS in their routine protocols. This is mainly due to the continued entry in the market of newly synthesized products, the low availability of reference standards, in particular of their metabolites, the low availability of immunochemical kits, etc. Moreover, many of the new compounds are very potent, and low doses ingested will lead to low concentrations in biological matrices, especially in hair. Hair analysis has become a powerful tool for detecting chronic drug use and has become a routine technique in forensic toxicology laboratories. The aim of this study was to set up analytical strategies to identify repeated consumption of NPS by hair analysis. Although UHPLC-MS/MS may represent the elective technique in studying NPS, a combination of both GC-MS and UHPLC-MS/MS techniques is useful in creating a complete toxicological image. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  7. Measuring the grafting density of nanoparticles in solution by analytical ultracentrifugation and total organic carbon analysis.

    Science.gov (United States)

    Benoit, Denise N; Zhu, Huiguang; Lilierose, Michael H; Verm, Raymond A; Ali, Naushaba; Morrison, Adam N; Fortner, John D; Avendano, Carolina; Colvin, Vicki L

    2012-11-06

    Many of the solution phase properties of nanoparticles, such as their colloidal stability and hydrodynamic diameter, are governed by the number of stabilizing groups bound to the particle surface (i.e., grafting density). Here, we show how two techniques, analytical ultracentrifugation (AUC) and total organic carbon analysis (TOC), can be applied separately to the measurement of this parameter. AUC directly measures the density of nanoparticle-polymer conjugates while TOC provides the total carbon content of its aqueous dispersions. When these techniques are applied to model gold nanoparticles capped with thiolated poly(ethylene glycol), the measured grafting densities across a range of polymer chain lengths, polymer concentrations, and nanoparticle diameters agree to within 20%. Moreover, the measured grafting densities correlate well with the polymer content determined by thermogravimetric analysis of solid conjugate samples. Using these tools, we examine the particle core diameter, polymer chain length, and polymer solution concentration dependence of nanoparticle grafting densities in a gold nanoparticle-poly(ethylene glycol) conjugate system.

  8. Analytical determination of flavonoids aimed to analysis of natural samples and active packaging applications.

    Science.gov (United States)

    Castro-López, María del Mar; López-Vilariño, José Manuel; González-Rodríguez, María Victoria

    2014-05-01

    Several HPLC and UHPLC developed methods were compared to analyse the natural antioxidants catechins and quercetin used in active packaging and functional foods. Photodiode array detector coupled with a fluorescence detector and compared with LTQ-Orbitrap-MS was used. UHPLC was investigated as quick alternative without compromising the separation, analysis time shortened up to 6-fold. The feasibility of the four developed methods was compared. Linearity up to 0.9995, low detection limits (between 0.02 and 0.7 for HPLC-PDA, 2 to 7-fold lower for HPLC- LTQ-Orbitrap-MS and from 0.2 to 2mgL(-)(1) for UHPLC-PDA) and good precision parameters (RSD lower than 0.06%) were obtained. All methods were successfully applied to natural samples. LTQ-Orbitrap-MS allowed to identify other analytes of interest too. Good feasibility of the methods was also concluded from the analysis of catechin and quercetin release from new active packaging materials based on polypropylene added with catechins and green tea. Copyright © 2013 Elsevier Ltd. All rights reserved.

  9. Improved process analytical technology for protein a chromatography using predictive principal component analysis tools.

    Science.gov (United States)

    Hou, Ying; Jiang, Canping; Shukla, Abhinav A; Cramer, Steven M

    2011-01-01

    Protein A chromatography is widely employed for the capture and purification of antibodies and Fc-fusion proteins. Due to the high cost of protein A resins, there is a significant economic driving force for using these chromatographic materials for a large number of cycles. The maintenance of column performance over the resin lifetime is also a significant concern in large-scale manufacturing. In this work, several statistical methods are employed to develop a novel principal component analysis (PCA)-based tool for predicting protein A chromatographic column performance over time. A method is developed to carry out detection of column integrity failures before their occurrence without the need for a separate integrity test. In addition, analysis of various transitions in the chromatograms was also employed to develop PCA-based models to predict both subtle and general trends in real-time protein A column yield decay. The developed approach has significant potential for facilitating timely and improved decisions in large-scale chromatographic operations in line with the process analytical technology (PAT) guidance from the Food and Drug Administration (FDA). © 2010 Wiley Periodicals, Inc.

  10. Analytical Kinematics and Coupled Vibrations Analysis of Mechanical System Operated by Solar Array Drive Assembly

    Science.gov (United States)

    Sattar, M.; Wei, C.; Jalali, A.; Sattar, R.

    2017-07-01

    To address the impact of solar array (SA) anomalies and vibrations on performance of precision space-based operations, it is important to complete its accurate jitter analysis. This work provides mathematical modelling scheme to approximate kinematics and coupled micro disturbance dynamics of rigid load supported and operated by solar array drive assembly (SADA). SADA employed in analysis provides a step wave excitation torque to activate the system. Analytical investigations into kinematics is accomplished by using generalized linear and Euler angle coordinates, applying multi-body dynamics concepts and transformations principles. Theoretical model is extended, to develop equations of motion (EoM), through energy method (Lagrange equation). The main emphasis is to research coupled frequency response by determining energies dissipated and observing dynamic behaviour of internal vibratory systems of SADA. The disturbance model captures discrete active harmonics of SADA, natural modes and vibration amplifications caused by interactions between active harmonics and structural modes of mechanical assembly. The proposed methodology can help to predict true micro disturbance nature of SADA operating rigid load. Moreover, performance outputs may be compared against actual mission requirements to assess precise spacecraft controller design to meet next space generation stringent accuracy goals.

  11. A clean laboratory for ultratrace analysis: the ultratrace analytical facility (UTAF)

    International Nuclear Information System (INIS)

    Jadhav, S.G.; Sounderajan, Suvarna; Kumar, Sanjukta A.; Udas, A.C.; Ramanathan, M.; Palrecha, M.M.; Sudersanan, M.

    2003-06-01

    Thare has been an increasing demand for the quantification of various elements at extremely low concentrations in a variety of samples such as high purity materials, environmental and biological samples. The need for a controlled environment to obtain reliable and reproducible data necessitates the use of strategies and practices to minimize contamination during the analytical procedure. This report describes the protocol observed in our clean laboratory to eliminate contamination and ensure low laboratory blanks and some of the methodologies developed to carry out the analysis. The analysis is carried out by Graphite Furnace Atomic Absorption Spectrometry and electrochemical techniques such as Anodic/ Cathodic / Adsorptive Stripping Voltammetry. Characterisation of 5N (total impurities 10 ppm) arsenic is routinely carried out. Al in serum of patients suffering from end stage renal failure are also analyzed. Pine leaves, spinach, carrot puree and milk powder have been characterized for Al and Hg content and bovine serum has been characterized for Cu, Zn, Na, K in samples as part of intercomparison exercises. (author)

  12. Cost analysis of erythropoietin versus blood transfusions for cervical cancer patients receiving chemoradiotherapy

    International Nuclear Information System (INIS)

    Kavanagh, Brian D.; Fischer, Bernard A.; Segreti, Eileen M.; Wheelock, John B.; Boardman, Cecilia; Roseff, Susan D.; Cardinale, Robert M.; Benedict, Stanley H.; Goram, Adrian L.

    2001-01-01

    Purpose: Red blood cell (RBC) transfusions or erythropoietin (EPO) can be used to evade the detrimental effects of anemia during radiotherapy, but the economic consequences of selecting either intervention are not well defined. The RBC transfusion needs during chemoradiotherapy for cervix cancer were quantified to allow comparison of RBC transfusion costs with the projected cost of EPO in this setting. Methods and Materials: For patients receiving pelvic radiotherapy, weekly cisplatin, and brachytherapy, the RBC units transfused during treatment were tallied. RBC transfusion costs per unit included the blood itself, laboratory fees, and expected value (risk multiplied by cost) of transfusion-related viral illness. EPO costs included the drug itself and supplemental RBC transfusions when hemoglobin was not adequately maintained. An EPO dosage based on reported usage in cervix cancer patients was applied. Results: Transfusions were given for hemoglobin <10 g/dL. Among 12 consecutive patients, 10 needed at least 1 U of RBC before or during treatment, most commonly after the fifth week. A total of 37 U was given during treatment, for an average of 3.1 U/patient. The sum total of the projected average transfusion-related costs was $990, compared with the total projected EPO-related costs of $3869. Conclusions: Because no proven clinical advantage has been documented for EPO compared with RBC transfusions to maintain hemoglobin during cervix cancer treatment, for most patients, transfusions are an appropriate and appealingly less expensive option

  13. Analysis for Resolution of Bistatic SAR Configuration with Geosynchronous Transmitter and UAV Receiver

    Directory of Open Access Journals (Sweden)

    Yicheng Jiang

    2013-01-01

    Full Text Available Bistatical SAR with geosynchronous illuminator and unmanned aerial vehicle receiver (GEO-UAV BiSAR has significant potential advantages in the field of continuous local observation under a dangerous environment within nearly 24 h. Due to the extreme platform velocity differences, the ellipse orbital movement of GEOSAR makes this BiSAR configuration not like the conventional spaceborne BiSAR. In this paper, based on the orbital kinetic characteristic of GEOSAR, we theoretically analyze the variations of bistatic configuration effect on common azimuth coverage and coherent accumulated time. In addition, two-dimension the resolution is deduced by geometrical configuration on the basis of gradient method. The simulations show that the appropriate selection of initial bistatic configuration can restrain from the appearance of the dead zone in common coverage. And the image results are obtained by frequency domain RD based on Method of Series Reversion (MSR. It is shown that GEO-UAV BiSAR has the high resolution ability.

  14. Receiver operating characteristic analysis of regional cerebral blood flow in Alzheimer's disease

    International Nuclear Information System (INIS)

    Zemcov, A.; Barclay, L.L.; Sansone, J.; Metz, C.E.

    1985-01-01

    Receiver operating characteristic (ROC) curves were used to quantitatively assess the ability of individual detectors in a 32-detector 133 Xe inhalation system to discriminate between two populations over the range of regional cerebral blood flow (rCBF) values. These populations were clinically evaluated as normal (age 63.1 +/- 13.1, n = 23) and presumed Alzheimer's disease (age 72.7 +/- 7.0, n = 82). Summary statistics showed that for homologous detectors the average value of blood flow in the normal group was greater than the flow value in the group of subjects with Alzheimer's disease. Conclusions drawn from single values of flow or mean hemispheric flow can lead to erroneous conclusions about hemisphere asymmetries. However, the dynamic relationship between the correct identifications (true positives) compared with incorrect identifications (false positives) of Alzheimer's disease at each detector varies over the range of blood flow values, and quantitative characterization of this relationship in terms of an ROC curve provides more insight into the structure of the data. Detectors approximating the speech, auditory and association cortex were most effective in discriminating between groups. Frontal detectors were marginally useful diagnostically

  15. Analytical quality assurance in veterinary drug residue analysis methods: matrix effects determination and monitoring for sulfonamides analysis.

    Science.gov (United States)

    Hoff, Rodrigo Barcellos; Rübensam, Gabriel; Jank, Louise; Barreto, Fabiano; Peralba, Maria do Carmo Ruaro; Pizzolato, Tânia Mara; Silvia Díaz-Cruz, M; Barceló, Damià

    2015-01-01

    In residue analysis of veterinary drugs in foodstuff, matrix effects are one of the most critical points. This work present a discuss considering approaches used to estimate, minimize and monitoring matrix effects in bioanalytical methods. Qualitative and quantitative methods for estimation of matrix effects such as post-column infusion, slopes ratios analysis, calibration curves (mathematical and statistical analysis) and control chart monitoring are discussed using real data. Matrix effects varying in a wide range depending of the analyte and the sample preparation method: pressurized liquid extraction for liver samples show matrix effects from 15.5 to 59.2% while a ultrasound-assisted extraction provide values from 21.7 to 64.3%. The matrix influence was also evaluated: for sulfamethazine analysis, losses of signal were varying from -37 to -96% for fish and eggs, respectively. Advantages and drawbacks are also discussed considering a workflow for matrix effects assessment proposed and applied to real data from sulfonamides residues analysis. Copyright © 2014 Elsevier B.V. All rights reserved.

  16. Automatic evaluation and data generation for analytical chemistry instrumental analysis exercises

    Directory of Open Access Journals (Sweden)

    Arsenio Muñoz de la Peña

    2014-01-01

    Full Text Available In general, laboratory activities are costly in terms of time, space, and money. As such, the ability to provide realistically simulated laboratory data that enables students to practice data analysis techniques as a complementary activity would be expected to reduce these costs while opening up very interesting possibilities. In the present work, a novel methodology is presented for design of analytical chemistry instrumental analysis exercises that can be automatically personalized for each student and the results evaluated immediately. The proposed system provides each student with a different set of experimental data generated randomly while satisfying a set of constraints, rather than using data obtained from actual laboratory work. This allows the instructor to provide students with a set of practical problems to complement their regular laboratory work along with the corresponding feedback provided by the system's automatic evaluation process. To this end, the Goodle Grading Management System (GMS, an innovative web-based educational tool for automating the collection and assessment of practical exercises for engineering and scientific courses, was developed. The proposed methodology takes full advantage of the Goodle GMS fusion code architecture. The design of a particular exercise is provided ad hoc by the instructor and requires basic Matlab knowledge. The system has been employed with satisfactory results in several university courses. To demonstrate the automatic evaluation process, three exercises are presented in detail. The first exercise involves a linear regression analysis of data and the calculation of the quality parameters of an instrumental analysis method. The second and third exercises address two different comparison tests, a comparison test of the mean and a t-paired test.

  17. Incorporating nuclear vibrational energies into the "atom in molecules" analysis: An analytical study.

    Science.gov (United States)

    Gharabaghi, Masumeh; Shahbazian, Shant

    2017-04-21

    The quantum theory of atoms in molecules (QTAIM) is based on the clamped nucleus paradigm and solely working with the electronic wavefunctions, so does not include nuclear vibrations in the AIM analysis. On the other hand, the recently extended version of the QTAIM, called the multi-component QTAIM (MC-QTAIM), incorporates both electrons and quantum nuclei, i.e., those nuclei treated as quantum waves instead of clamped point charges, into the AIM analysis using non-adiabatic wavefunctions. Thus, the MC-QTAIM is the natural framework to incorporate the role of nuclear vibrations into the AIM analysis. In this study, within the context of the MC-QTAIM, the formalism of including nuclear vibrational energy in the atomic basin energy is developed in detail and its contribution is derived analytically using the recently proposed non-adiabatic Hartree product nuclear wavefunction. It is demonstrated that within the context of this wavefunction, the quantum nuclei may be conceived pseudo-adiabatically as quantum oscillators and both isotropic harmonic and anisotropic anharmonic oscillator models are used to compute the zero-point nuclear vibrational energy contribution to the basin energies explicitly. Inspired by the results gained within the context of the MC-QTAIM analysis, a heuristic approach is proposed within the context of the QTAIM to include nuclear vibrational energy in the basin energy from the vibrational wavefunction derived adiabatically. The explicit calculation of the basin contribution of the zero-point vibrational energy using the uncoupled harmonic oscillator model leads to results consistent with those derived from the MC-QTAIM.

  18. Quantitative Proteomic Analysis of Serum Proteins from Oral Cancer Patients: Comparison of Two Analytical Methods

    Directory of Open Access Journals (Sweden)

    Yan Yang

    2014-08-01

    Full Text Available Serum proteomic analysis can be a valuable approach for the discovery of protein biomarkers for early detection or monitoring of a disease. In this study, two analytical methods were compared for quantification of serum proteins in patients with oral cancer. In the first approach, we quantified serum proteins between oral squamous cell carcinoma (OSCC and healthy control subjects by performing in-solution digestion of serum proteins, isobaric tags for relative and absolute quantification (iTRAQ labeling of the resulting peptides, strong cation exchange (SCX fractionation of labeled peptides and finally capillary liquid chromatography with tandem mass spectrometry (LC-MS/MS analysis of the peptides. In the second approach, we first separated serum proteins with SDS-PAGE. The gel-separated proteins were then digested with trypsin and the resulting peptides were labeled with iTRAQ and analyzed with LC-MS/MS for protein quantification. A total of 319 serum proteins were quantified with the first proteomic approach whereas a total of 281 proteins were quantified by the second proteomic approach. Most of the proteins were identified and quantified by both approaches, suggesting that these methods are similarly effective for serum proteome analysis. This study provides compelling evidence that quantitative serum proteomic analysis of OSCC is a valuable approach for identifying differentially expressed proteins in cancer patients’ circulation systems that may be used as potential biomarkers for disease detection. Further validation in large oral cancer patient populations may lead to a simple and low invasive clinical tool for OSCC diagnosis or monitoring.

  19. Receiver operating characteristic analysis and its potential role in evaluating the effect of head movement in PET of the brain

    International Nuclear Information System (INIS)

    Patterson, H.; Clarke, G.H.; Lombardo, P.; McKay, W.J.; Austin and Repatriation Medical Centre, Heidelberg, VIC

    1999-01-01

    Full text: We outline an example of receiver operating characteristic (ROC) analysis in the assessment of image quality. ROC analysis is a measure of image quality that accounts for the consequences of the decision and the role of the observer. Kim and Haynie (Nuclear Diagnostic Imaging: Practical Clinical Applications. Melbourne: Macmillan, 1987) describe ROC analysis as an 'objective approach to the evaluation of diagnostic decision making'. ROC analysis is an ideal technique for evaluating images of a Hoffman brain phantom obtained using positron emission tomography. Images have been acquired with the phantom in different positions. The position of the phantom and the time the phantom remained in each position was based on the measurements of head movement during simulated brain imaging (Patterson et al., Technologists Symposium, ANZSNM, 1998). This study was undertaken to explore the potential of ROC analysis in determining the effect of movement on the ability to detect lesions of various sizes

  20. Latent Class Analysis of Conduct Problems of Elementary Students Receiving Special Education Services

    Science.gov (United States)

    Toupin, Jean; Déry, Michèle; Verlaan, Pierrette; Lemelin, Jean-Pascal; Lecocq, Aurélie; Jagiellowicz, Jadwiga

    2016-01-01

    Students with conduct problems (CPs) may present heterogeneity in terms of behavioral manifestations and service needs. Previous studies using Latent Class Analysis (LCA) to capture this heterogeneity have been conducted mostly with community samples and have often applied a narrow definition of CP. Considering this context, this study…

  1. Moho depth and Vp/Vs in Ireland from teleseismic receiver functions analysis

    Science.gov (United States)

    Licciardi, A.; Agostinetti, N. Piana; Lebedev, S.; Schaeffer, A. J.; Readman, P. W.; Horan, C.

    2014-10-01

    This work presents a teleseismic P-wave receiver function study on 34 stations deployed across Ireland in order to determine the first-order crustal properties, thickness (H) and mean crustal Vp/Vs, over the entire island. We apply the H - Vp/Vs stacking method, which exploits the information contained in both the Ps and the multiple phases from the free-surface. In this way, we obtain the first Moho depth and Vp/Vs maps of Ireland based on a uniform distribution of measurements. The results are used to examine in detail the lateral variation of crustal thickness and Vp/Vs ratio across the major terrane boundaries in Ireland. Our results show a good agreement with the available previous estimates from onshore wide-angle/refraction experiments and add new information in poorly constrained areas such as Northern Ireland and the NW coast of Ireland. The mean Vp/Vs ratio is 1.73 ± 0.05 with a consistently low (≈1.70) value in the Leinster domain and in central Ireland. The mean crustal thickness is 30.9 ± 2.3 km. The southern portion of the island shows a nearly flat Moho at a depth of 32-33 km, while north of the Southern Uplands Fault, a relatively higher spatial frequency variation in Moho topography exists with values ranging from 28 to 32 km. This reflects the complex history of multiphase terranes accretion during the Caledonian orogeny, although locally, the superposition of more recent geological processes is not excluded. Crossing the Iapetus Suture Zone, our results support the presence of a `transitional' Moho, that is, a 3-4 km smooth seismic transition between crust and mantle, while Moho depth remains constant. Anomalous values in Northern Ireland are interpreted as evidence of a 5- to 6-km-thick high S-wave velocity layer just above the Moho.

  2. Longitudinal analysis of quality of life in patients receiving conformal radiation therapy for prostate cancer

    International Nuclear Information System (INIS)

    Geinitz, Hans; Thamm, Reinhard; Scholz, Christian; Heinrich, Christine; Prause, Nina; Kerndl, Simone; Molls, Michael; Zimmermann, Frank B.; Keller, Monika; Busch, Raymonde

    2010-01-01

    Purpose: To prospectively assess quality of life (QoL) in patients receiving conformal radiation therapy (CRT) for prostate cancer. Patients and Methods: 78 men with definitive CRT for prostate cancer were entered into the study. Patients were assessed before CRT, at 40 and 60 Gy, and 2, 12 and 24 months after the end of treatment. QoL was assessed using the EORTC Quality of Life Questionnaire C30 and the prostate module PR25. Changes in mean QoL scores with time of ≥ 10 points were considered clinically relevant. Results: Global QoL did not change statistically significant during CRT and was slightly above baseline levels during follow-up. CRT had a statistically significant negative short-term impact on role functioning, fatigue, and PR25 urinary symptoms. The scores recovered within 2 months to 1 year after CRT. Emotional functioning and social functioning scores slightly increased during and after CRT. Role functioning decreased by > 10 points at 60 Gy and urinary symptoms decreased by > 10 points at 40 and 60 Gy. All other differences were < 10 points. A high number of concomitant diseases and having no children were negative pretreatment predictors for long-term global QoL. Conclusion: Definitive CRT for prostate cancer does not compromise global QoL during therapy and up to 2 years after treatment. It has a limited negative effect on role functioning, urinary symptoms and, to a lesser extent, on fatigue with restitution within 2 months to 1 year after treatment. (orig.)

  3. Longitudinal analysis of quality of life in patients receiving conformal radiation therapy for prostate cancer

    Energy Technology Data Exchange (ETDEWEB)

    Geinitz, Hans; Thamm, Reinhard; Scholz, Christian; Heinrich, Christine; Prause, Nina; Kerndl, Simone; Molls, Michael; Zimmermann, Frank B. [Dept. of Radiotherapy and Radiooncology, Technische Univ. Muenchen (Germany); Keller, Monika [Psychooncology Section, Dept. of Psychosomatic and General Clinical Medicine, Univ. Hospital, Heidelberg (Germany); Busch, Raymonde [Inst. of Medical Statistics and Epidemiology, Technische Univ. Muenchen (Germany)

    2010-01-15

    Purpose: To prospectively assess quality of life (QoL) in patients receiving conformal radiation therapy (CRT) for prostate cancer. Patients and Methods: 78 men with definitive CRT for prostate cancer were entered into the study. Patients were assessed before CRT, at 40 and 60 Gy, and 2, 12 and 24 months after the end of treatment. QoL was assessed using the EORTC Quality of Life Questionnaire C30 and the prostate module PR25. Changes in mean QoL scores with time of {>=} 10 points were considered clinically relevant. Results: Global QoL did not change statistically significant during CRT and was slightly above baseline levels during follow-up. CRT had a statistically significant negative short-term impact on role functioning, fatigue, and PR25 urinary symptoms. The scores recovered within 2 months to 1 year after CRT. Emotional functioning and social functioning scores slightly increased during and after CRT. Role functioning decreased by > 10 points at 60 Gy and urinary symptoms decreased by > 10 points at 40 and 60 Gy. All other differences were < 10 points. A high number of concomitant diseases and having no children were negative pretreatment predictors for long-term global QoL. Conclusion: Definitive CRT for prostate cancer does not compromise global QoL during therapy and up to 2 years after treatment. It has a limited negative effect on role functioning, urinary symptoms and, to a lesser extent, on fatigue with restitution within 2 months to 1 year after treatment. (orig.)

  4. Analysis of the coupling efficiency of a tapered space receiver with a calculus mathematical model

    Science.gov (United States)

    Hu, Qinggui; Mu, Yining

    2018-03-01

    We establish a calculus mathematical model to study the coupling characteristics of tapered optical fibers in a space communications system, and obtained the coupling efficiency equation. Then, using MATLAB software, the solution was calculated. After this, the sample was produced by the mature flame-brush technique. The experiment was then performed, and the results were in accordance with the theoretical analysis. This shows that the theoretical analysis was correct and indicates that a tapered structure could improve its tolerance with misalignment. Project supported by The National Natural Science Foundation of China (grant no. 61275080); 2017 Jilin Province Science and Technology Development Plan-Science and Technology Innovation Fund for Small and Medium Enterprises (20170308029HJ); ‘thirteen five’ science and technology research project of the Department of Education of Jilin 2016 (16JK009).

  5. Analysis of the flexible receiver lifting yoke and blast shield assembly. Tank 241SY101

    International Nuclear Information System (INIS)

    Huang, F.H.

    1995-01-01

    The analysis of the lifting yoke and blast shield assembly considers the bending stress, weld strength, and resistance of the lug hole to tear out. The bending stress of the lifting lugs is evaluated to ensure that they meet the requirements of the American Institute for Steel Construction (AISC 1989). Also considered in the calculations is the capability of the thick lugs to withstand the weight of the pump together with that of the container and strongback during rotation to the horizontal position

  6. Final safety analysis report (FSAR) for waste receiving and processing (WRAP) facility

    International Nuclear Information System (INIS)

    Weidert, J.R.

    1997-01-01

    This safety analysis report provides a summary description of the WRAP Facility, focusing on significant safety-related characteristics of the location and facility design. This report demonstrates that adherence to the safety basis wi11 ensure necessary operational safety considerations have been addressed sufficiently and justifies the adequacy of the safety basis in protecting the health and safety of the public, workers, and the environment

  7. Procedure for hazards analysis of plutonium gloveboxes used in analytical chemistry operations

    International Nuclear Information System (INIS)

    Delvin, W.L.

    1977-06-01

    A procedure is presented to identify and assess hazards associated with gloveboxes used for analytical chemistry operations involving plutonium. This procedure is based upon analytic tree methodology and it has been adapted from the US Energy Research and Development Administration's safety program, the Management Oversight and Risk Tree

  8. The Promise and Peril of Predictive Analytics in Higher Education: A Landscape Analysis

    Science.gov (United States)

    Ekowo, Manuela; Palmer, Iris

    2016-01-01

    Predictive analytics in higher education is a hot-button topic among educators and administrators as institutions strive to better serve students by becoming more data-informed. In this paper, the authors describe how predictive analytics are used in higher education to identify students who need extra support, steer students in courses they will…

  9. A Multi-Criteria Analysis for the Evaluation of Social Housing Proposals: from the Analytic Hierarchy Process (AHP to the Analytic Network Process (ANP

    Directory of Open Access Journals (Sweden)

    Barbara Ferri

    2017-02-01

    Full Text Available Social housing requires appropriate evaluation models of projects, considering them from multiple perspectives: architectural, technical, environmental, economic, financial, paying particular attention to social aspects. The study proposes the use of a multi criteria evaluation model, based on the hierarchical (AHP and network (ANP analysis, as support in decision-making to guide practitioners and policy on the choice among alternative interventions. These methods allow to consider the overall effect of projects on urban system and the different points of view of those concerned, in an integrated and participatory approach. Interesting research perspectives concern the application of these evaluation approaches to case studies related to neighborhoods in which urban planning provides for social housing. The analysis will address the recent proposals for social housing in the city of Pescara (Italy, and in particular the urban transformation that is expected to achieve by means of the Integrated Urban Development Programme on the south-west of the city, whose regeneration was started by the Community Programme Urban 2.   Un’Analisi Multi Criteri per la Valutazione delle Proposte di Housing Sociale: dall’Analytic Hierarchy Process (AHP all’Analytic Network Process (ANP I modelli insediativi di social housing richiedono idonei strumenti valutativi degli interventi immobiliari, considerandoli da molteplici punti di vista: architettonici, urbanistici, ambientali, economici, finanziari, con particolare attenzione agli aspetti sociali. Lo studio propone l’impiego di un modello valutativo multicriteri basato sull’analisi gerarchica (AHP e a rete (ANP, come supporto ai processi decisionali riguardanti la scelta tra interventi alternativi di edilizia residenziale sociale, considerando il loro effetto complessivo sul sistema urbano secondo un approccio integrato e partecipativo. Parole Chiave: analisi multicriteri, edilizia residenziale sociale

  10. Control of Nausea Based on Risk Analysis in Patients with Esophageal and Gastric Cancer Who Received Cisplatin-based Chemotherapy.

    Science.gov (United States)

    Fujii, Hironori; Iihara, Hirotoshi; Kajikawa, Noriko; Kobayashi, Ryo; Suzuki, Akio; Tanaka, Yoshihiro; Yamaguchi, Kazuya; Yoshida, Kazuhiro; Itoh, Yoshinori

    2017-12-01

    Cisplatin is commonly used for esophageal and gastric cancer, but has a high emetic risk. Although the control of vomiting is favorable, nausea is still poorly controlled in patients receiving cisplatin-based regimens. The present study was designed to determine the risks for cisplatin-induced nausea. The effect of olanzapine, an antipsychotic drug, as an antiemetic for patients with risk of poor control of nausea was subsequently examined. The prevalence of antiemetic medication and the control of nausea and vomiting were retrospectively examined in patients with esophageal or gastric cancer receiving the first cycle of cisplatin-based chemotherapy. Risks for nausea were analyzed by multivariate logistic regression analysis, in which threshold for age and cisplatin dose wer assessed by receiver operating characteristic curve analysis. A total of 186 patients received cisplatin-based regimens during January 2011 and December 2016. Guideline-consistent antiemetic medication was administered to all patients. Although the rate of no vomiting was high (93%), the rate of non-significant (grade 2 or more) nausea was insufficient (64%) during the overall period. Risk analysis showed that cisplatin dose of 50 mg/m 2 or more and female gender were significant risks for nausea. Addition of olanzapine, but not of prochlorperazine, to the standard antiemetic medication was effective in suppressing nausea in patients who experienced nausea in the first cycle. Being female and cisplatin doses at 50 mg/m 2 or more were demonstrated to increase risk for nausea. Addition of olanzapine to the standard medication was effective in preventing nausea in high-risk patients with esophageal and gastric cancer. Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

  11. The Role of Teamwork in the Analysis of Big Data: A Study of Visual Analytics and Box Office Prediction.

    Science.gov (United States)

    Buchanan, Verica; Lu, Yafeng; McNeese, Nathan; Steptoe, Michael; Maciejewski, Ross; Cooke, Nancy

    2017-03-01

    Historically, domains such as business intelligence would require a single analyst to engage with data, develop a model, answer operational questions, and predict future behaviors. However, as the problems and domains become more complex, organizations are employing teams of analysts to explore and model data to generate knowledge. Furthermore, given the rapid increase in data collection, organizations are struggling to develop practices for intelligence analysis in the era of big data. Currently, a variety of machine learning and data mining techniques are available to model data and to generate insights and predictions, and developments in the field of visual analytics have focused on how to effectively link data mining algorithms with interactive visuals to enable analysts to explore, understand, and interact with data and data models. Although studies have explored the role of single analysts in the visual analytics pipeline, little work has explored the role of teamwork and visual analytics in the analysis of big data. In this article, we present an experiment integrating statistical models, visual analytics techniques, and user experiments to study the role of teamwork in predictive analytics. We frame our experiment around the analysis of social media data for box office prediction problems and compare the prediction performance of teams, groups, and individuals. Our results indicate that a team's performance is mediated by the team's characteristics such as openness of individual members to others' positions and the type of planning that goes into the team's analysis. These findings have important implications for how organizations should create teams in order to make effective use of information from their analytic models.

  12. A Hybrid Approach for Reliability Analysis Based on Analytic Hierarchy Process and Bayesian Network

    International Nuclear Information System (INIS)

    Zubair, Muhammad

    2014-01-01

    By using analytic hierarchy process (AHP) and Bayesian Network (BN) the present research signifies the technical and non-technical issues of nuclear accidents. The study exposed that the technical faults was one major reason of these accidents. Keep an eye on other point of view it becomes clearer that human behavior like dishonesty, insufficient training, and selfishness are also play a key role to cause these accidents. In this study, a hybrid approach for reliability analysis based on AHP and BN to increase nuclear power plant (NPP) safety has been developed. By using AHP, best alternative to improve safety, design, operation, and to allocate budget for all technical and non-technical factors related with nuclear safety has been investigated. We use a special structure of BN based on the method AHP. The graphs of the BN and the probabilities associated with nodes are designed to translate the knowledge of experts on the selection of best alternative. The results show that the improvement in regulatory authorities will decrease failure probabilities and increase safety and reliability in industrial area.

  13. A Big Data Analytics Pipeline for the Analysis of TESS Full Frame Images

    Science.gov (United States)

    Wampler-Doty, Matthew; Pierce Doty, John

    2015-12-01

    We present a novel method for producing a catalogue of extra-solar planets and transients using the full frame image data from TESS. Our method involves (1) creating a fast Monte Carlo simulation of the TESS science instruments, (2) using the simulation to create a labeled dataset consisting of exoplanets with various orbital durations as well as transients (such as tidal disruption events), (3) using supervised machine learning to find optimal matched filters, Support Vector Machines (SVMs) and statistical classifiers (i.e. naïve Bayes and Markov Random Fields) to detect astronomical objects of interest and (4) “Big Data” analysis to produce a catalogue based on the TESS data. We will apply the resulting methods to all stars in the full frame images. We hope that by providing libraries that conform to industry standards of Free Open Source Software we may invite researchers from the astronomical community as well as the wider data-analytics community to contribute to our effort.

  14. A Hierarchical Aggregation Approach for Indicators Based on Data Envelopment Analysis and Analytic Hierarchy Process

    Directory of Open Access Journals (Sweden)

    Mohammad Sadegh Pakkar

    2016-01-01

    Full Text Available This research proposes a hierarchical aggregation approach using Data Envelopment Analysis (DEA and Analytic Hierarchy Process (AHP for indicators. The core logic of the proposed approach is to reflect the hierarchical structures of indicators and their relative priorities in constructing composite indicators (CIs, simultaneously. Under hierarchical structures, the indicators of similar characteristics can be grouped into sub-categories and further into categories. According to this approach, we define a domain of composite losses, i.e., a reduction in CI values, based on two sets of weights. The first set represents the weights of indicators for each Decision Making Unit (DMU with the minimal composite loss, and the second set represents the weights of indicators bounded by AHP with the maximal composite loss. Using a parametric distance model, we explore various ranking positions for DMUs while the indicator weights obtained from a three-level DEA-based CI model shift towards the corresponding weights bounded by AHP. An illustrative example of road safety performance indicators (SPIs for a set of European countries highlights the usefulness of the proposed approach.

  15. Analytical method for analysis of electromagnetic scattering from inhomogeneous spherical structures using duality principles

    Science.gov (United States)

    Kiani, M.; Abdolali, A.; Safari, M.

    2018-03-01

    In this article, an analytical approach is presented for the analysis of electromagnetic (EM) scattering from radially inhomogeneous spherical structures (RISSs) based on the duality principle. According to the spherical symmetry, similar angular dependencies in all the regions are considered using spherical harmonics. To extract the radial dependency, the system of differential equations of wave propagation toward the inhomogeneity direction is equated with the dual planar ones. A general duality between electromagnetic fields and parameters and scattering parameters of the two structures is introduced. The validity of the proposed approach is verified through a comprehensive example. The presented approach substitutes a complicated problem in spherical coordinate to an easy, well posed, and previously solved problem in planar geometry. This approach is valid for all continuously varying inhomogeneity profiles. One of the major advantages of the proposed method is the capability of studying two general and applicable types of RISSs. As an interesting application, a class of lens antenna based on the physical concept of the gradient refractive index material is introduced. The approach is used to analyze the EM scattering from the structure and validate strong performance of the lens.

  16. Application of multi attribute failure mode analysis of milk production using analytical hierarchy process method

    Science.gov (United States)

    Rucitra, A. L.

    2018-03-01

    Pusat Koperasi Induk Susu (PKIS) Sekar Tanjung, East Java is one of the modern dairy industries producing Ultra High Temperature (UHT) milk. A problem that often occurs in the production process in PKIS Sekar Tanjung is a mismatch between the production process and the predetermined standard. The purpose of applying Analytical Hierarchy Process (AHP) was to identify the most potential cause of failure in the milk production process. Multi Attribute Failure Mode Analysis (MAFMA) method was used to eliminate or reduce the possibility of failure when viewed from the failure causes. This method integrates the severity, occurrence, detection, and expected cost criteria obtained from depth interview with the head of the production department as an expert. The AHP approach was used to formulate the priority ranking of the cause of failure in the milk production process. At level 1, the severity has the highest weight of 0.41 or 41% compared to other criteria. While at level 2, identifying failure in the UHT milk production process, the most potential cause was the average mixing temperature of more than 70 °C which was higher than the standard temperature (≤70 ° C). This failure cause has a contributes weight of 0.47 or 47% of all criteria Therefore, this study suggested the company to control the mixing temperature to minimise or eliminate the failure in this process.

  17. Analytic hierarchy process analysis for choosing a corporate social entrepreneurship strategy

    Directory of Open Access Journals (Sweden)

    Hadad Shahrazad

    2015-10-01

    Full Text Available After conducting an extensive analysis of both the specialised literature and practice and identifying three types of corporate social entrepreneurship in my PhD thesis titled “Corporate social entrepreneurship - the new paradigm of reshaping and rethinking business”, I decided to determine which of the three approaches is mostly suited for the Romanian market. The three types of corporate social entrepreneurship: corporate social entrepreneurship as local development tool, corporate social entrepreneurship as market development tool, and corporate social entrepreneurship as transformational innovation tool were organised as the alternatives of a carefully constructed hierarchy having as criteria: return on investment (which does not necessarily refer to the money that the company invests in the strategy; the term is derived from sustainability and scalability, degree of novelty, pre-entry knowledge and interest in solving the communities’ social problems. The questionnaire constructed based on the hierarchy using analytic hierarchy processes was distributed to experts (business developers coming from the following industries or sectors: beverages, IT, banking, furniture, and automotive. The research reveals which is the approach most likely to be employed by Romanian business developers. The results may be inferred to the sum of businesses represented by the expert business developers who were part of the research.

  18. Tools for the quantitative analysis of sedimentation boundaries detected by fluorescence optical analytical ultracentrifugation.

    Directory of Open Access Journals (Sweden)

    Huaying Zhao

    Full Text Available Fluorescence optical detection in sedimentation velocity analytical ultracentrifugation allows the study of macromolecules at nanomolar concentrations and below. This has significant promise, for example, for the study of systems of high-affinity protein interactions. Here we describe adaptations of the direct boundary modeling analysis approach implemented in the software SEDFIT that were developed to accommodate unique characteristics of the confocal fluorescence detection system. These include spatial gradients of signal intensity due to scanner movements out of the plane of rotation, temporal intensity drifts due to instability of the laser and fluorophores, and masking of the finite excitation and detection cone by the sample holder. In an extensive series of experiments with enhanced green fluorescent protein ranging from low nanomolar to low micromolar concentrations, we show that the experimental data provide sufficient information to determine the parameters required for first-order approximation of the impact of these effects on the recorded data. Systematic deviations of fluorescence optical sedimentation velocity data analyzed using conventional sedimentation models developed for absorbance and interference optics are largely removed after these adaptations, resulting in excellent fits that highlight the high precision of fluorescence sedimentation velocity data, thus allowing a more detailed quantitative interpretation of the signal boundaries that is otherwise not possible for this system.

  19. Application of Dynamic Analysis in Semi-Analytical Finite Element Method

    Directory of Open Access Journals (Sweden)

    Pengfei Liu

    2017-08-01

    Full Text Available Analyses of dynamic responses are significantly important for the design, maintenance and rehabilitation of asphalt pavement. In order to evaluate the dynamic responses of asphalt pavement under moving loads, a specific computational program, SAFEM, was developed based on a semi-analytical finite element method. This method is three-dimensional and only requires a two-dimensional FE discretization by incorporating Fourier series in the third dimension. In this paper, the algorithm to apply the dynamic analysis to SAFEM was introduced in detail. Asphalt pavement models under moving loads were built in the SAFEM and commercial finite element software ABAQUS to verify the accuracy and efficiency of the SAFEM. The verification shows that the computational accuracy of SAFEM is high enough and its computational time is much shorter than ABAQUS. Moreover, experimental verification was carried out and the prediction derived from SAFEM is consistent with the measurement. Therefore, the SAFEM is feasible to reliably predict the dynamic response of asphalt pavement under moving loads, thus proving beneficial to road administration in assessing the pavement’s state.

  20. Network Traffic Analysis With Query Driven VisualizationSC 2005HPC Analytics Results

    Energy Technology Data Exchange (ETDEWEB)

    Stockinger, Kurt; Wu, Kesheng; Campbell, Scott; Lau, Stephen; Fisk, Mike; Gavrilov, Eugene; Kent, Alex; Davis, Christopher E.; Olinger,Rick; Young, Rob; Prewett, Jim; Weber, Paul; Caudell, Thomas P.; Bethel,E. Wes; Smith, Steve

    2005-09-01

    Our analytics challenge is to identify, characterize, and visualize anomalous subsets of large collections of network connection data. We use a combination of HPC resources, advanced algorithms, and visualization techniques. To effectively and efficiently identify the salient portions of the data, we rely on a multi-stage workflow that includes data acquisition, summarization (feature extraction), novelty detection, and classification. Once these subsets of interest have been identified and automatically characterized, we use a state-of-the-art-high-dimensional query system to extract data subsets for interactive visualization. Our approach is equally useful for other large-data analysis problems where it is more practical to identify interesting subsets of the data for visualization than to render all data elements. By reducing the size of the rendering workload, we enable highly interactive and useful visualizations. As a result of this work we were able to analyze six months worth of data interactively with response times two orders of magnitude shorter than with conventional methods.

  1. GeneAnalytics Pathway Analysis and Genetic Overlap among Autism Spectrum Disorder, Bipolar Disorder and Schizophrenia

    Directory of Open Access Journals (Sweden)

    Naveen S. Khanzada

    2017-02-01

    Full Text Available Bipolar disorder (BPD and schizophrenia (SCH show similar neuropsychiatric behavioral disturbances, including impaired social interaction and communication, seen in autism spectrum disorder (ASD with multiple overlapping genetic and environmental influences implicated in risk and course of illness. GeneAnalytics software was used for pathway analysis and genetic profiling to characterize common susceptibility genes obtained from published lists for ASD (792 genes, BPD (290 genes and SCH (560 genes. Rank scores were derived from the number and nature of overlapping genes, gene-disease association, tissue specificity and gene functions subdivided into categories (e.g., diseases, tissues or functional pathways. Twenty-three genes were common to all three disorders and mapped to nine biological Superpathways including Circadian entrainment (10 genes, score = 37.0, Amphetamine addiction (five genes, score = 24.2, and Sudden infant death syndrome (six genes, score = 24.1. Brain tissues included the medulla oblongata (11 genes, score = 2.1, thalamus (10 genes, score = 2.0 and hypothalamus (nine genes, score = 2.0 with six common genes (BDNF, DRD2, CHRNA7, HTR2A, SLC6A3, and TPH2. Overlapping genes impacted dopamine and serotonin homeostasis and signal transduction pathways, impacting mood, behavior and physical activity level. Converging effects on pathways governing circadian rhythms support a core etiological relationship between neuropsychiatric illnesses and sleep disruption with hypoxia and central brain stem dysfunction.

  2. Stable isotope ratio analysis: A potential analytical tool for the authentication of South African lamb meat.

    Science.gov (United States)

    Erasmus, Sara Wilhelmina; Muller, Magdalena; van der Rijst, Marieta; Hoffman, Louwrens Christiaan

    2016-02-01

    Stable isotope ratios ((13)C/(12)C and (15)N/(14)N) of South African Dorper lambs from farms with different vegetation types were measured by isotope ratio mass spectrometry (IRMS), to evaluate it as a tool for the authentication of origin and feeding regime. Homogenised and defatted meat of the Longissimus lumborum (LL) muscle of lambs from seven different farms was assessed. The δ(13)C values were affected by the origin of the meat, mainly reflecting the diet. The Rûens and Free State farms had the lowest (p ⩽ 0.05) δ(15)N values, followed by the Northern Cape farms, with Hantam Karoo/Calvinia having the highest δ(15)N values. Discriminant analysis showed δ(13)C and δ(15)N differences as promising results for the use of IRMS as a reliable analytical tool for lamb meat authentication. The results suggest that diet, linked to origin, is an important factor to consider regarding region of origin classification for South African lamb. Copyright © 2015 Elsevier Ltd. All rights reserved.

  3. Shape Analysis of DNA-Au Hybrid Particles by Analytical Ultracentrifugation.

    Science.gov (United States)

    Urban, Maximilan J; Holder, Isabelle T; Schmid, Marius; Fernandez Espin, Vanesa; Garcia de la Torre, Jose; Hartig, Jörg S; Cölfen, Helmut

    2016-08-23

    Current developments in nanotechnology have increased the demand for nanocrystal assemblies with well-defined shapes and tunable sizes. DNA is a particularly well-suited building block in nanoscale assemblies because of its scalable sizes, conformational variability, and convenient self-assembly capabilities via base pairing. In hybrid materials, gold nanoparticles (AuNPs) can be assembled into nanoparticle structures with programmable interparticle distances by applying appropriate DNA sequences. However, the development of stoichiometrically defined DNA/NP structures is still challenging since product mixtures are frequently obtained and their purification and characterization is the rate-limiting step in the development of DNA-NP hybrid assemblies. Improvements in nanostructure fractionation and characterization techniques offer great potential for nanotechnology applications in general. This study reports the application of analytical ultracentrifugation (AUC) for the characterization of anisotropic DNA-linked metal-crystal assemblies. On the basis of transmission electron microscopy data and the DNA primary sequence, hydrodynamic bead models are set up for the interpretation of the measured frictional ratios and sedimentation coefficients. We demonstrate that the presence of single DNA strands on particle surfaces as well as the shape factors of multiparticle structures in mixtures can be quantitatively described by AUC. This study will significantly broaden the possibilities to analyze mixtures of shape-anisotropic nanoparticle assemblies. By establishing insights into the analysis of nanostructure mixtures based on fundamental principles of sedimentation, a wide range of potential applications in basic research and industry become accessible.

  4. Application of Dynamic Analysis in Semi-Analytical Finite Element Method.

    Science.gov (United States)

    Liu, Pengfei; Xing, Qinyan; Wang, Dawei; Oeser, Markus

    2017-08-30

    Analyses of dynamic responses are significantly important for the design, maintenance and rehabilitation of asphalt pavement. In order to evaluate the dynamic responses of asphalt pavement under moving loads, a specific computational program, SAFEM, was developed based on a semi-analytical finite element method. This method is three-dimensional and only requires a two-dimensional FE discretization by incorporating Fourier series in the third dimension. In this paper, the algorithm to apply the dynamic analysis to SAFEM was introduced in detail. Asphalt pavement models under moving loads were built in the SAFEM and commercial finite element software ABAQUS to verify the accuracy and efficiency of the SAFEM. The verification shows that the computational accuracy of SAFEM is high enough and its computational time is much shorter than ABAQUS. Moreover, experimental verification was carried out and the prediction derived from SAFEM is consistent with the measurement. Therefore, the SAFEM is feasible to reliably predict the dynamic response of asphalt pavement under moving loads, thus proving beneficial to road administration in assessing the pavement's state.

  5. General analytical solutions for DC/AC circuit-network analysis

    Science.gov (United States)

    Rubido, Nicolás; Grebogi, Celso; Baptista, Murilo S.

    2017-06-01

    In this work, we present novel general analytical solutions for the currents that are developed in the edges of network-like circuits when some nodes of the network act as sources/sinks of DC or AC current. We assume that Ohm's law is valid at every edge and that charge at every node is conserved (with the exception of the source/sink nodes). The resistive, capacitive, and/or inductive properties of the lines in the circuit define a complex network structure with given impedances for each edge. Our solution for the currents at each edge is derived in terms of the eigenvalues and eigenvectors of the Laplacian matrix of the network defined from the impedances. This derivation also allows us to compute the equivalent impedance between any two nodes of the circuit and relate it to currents in a closed circuit which has a single voltage generator instead of many input/output source/sink nodes. This simplifies the treatment that could be done via Thévenin's theorem. Contrary to solving Kirchhoff's equations, our derivation allows to easily calculate the redistribution of currents that occurs when the location of sources and sinks changes within the network. Finally, we show that our solutions are identical to the ones found from Circuit Theory nodal analysis.

  6. On the Multilevel Nature of Meta-Analysis: A Tutorial, Comparison of Software Programs, and Discussion of Analytic Choices.

    Science.gov (United States)

    Pastor, Dena A; Lazowski, Rory A

    2018-01-01

    The term "multilevel meta-analysis" is encountered not only in applied research studies, but in multilevel resources comparing traditional meta-analysis to multilevel meta-analysis. In this tutorial, we argue that the term "multilevel meta-analysis" is redundant since all meta-analysis can be formulated as a special kind of multilevel model. To clarify the multilevel nature of meta-analysis the four standard meta-analytic models are presented using multilevel equations and fit to an example data set using four software programs: two specific to meta-analysis (metafor in R and SPSS macros) and two specific to multilevel modeling (PROC MIXED in SAS and HLM). The same parameter estimates are obtained across programs underscoring that all meta-analyses are multilevel in nature. Despite the equivalent results, not all software programs are alike and differences are noted in the output provided and estimators available. This tutorial also recasts distinctions made in the literature between traditional and multilevel meta-analysis as differences between meta-analytic choices, not between meta-analytic models, and provides guidance to inform choices in estimators, significance tests, moderator analyses, and modeling sequence. The extent to which the software programs allow flexibility with respect to these decisions is noted, with metafor emerging as the most favorable program reviewed.

  7. Comparative analysis of collective doses received since 1976 at the Ardennes nuclear power plant

    International Nuclear Information System (INIS)

    Aye, Louis

    1980-01-01

    The analysis of the collective doses at the Centrale nucleaire des Ardennes povides valuable data about the origin of exposures in P.W.R. reactors and their evolution regarding the increase of activity of the circuits after more than 10 years of operation. The investigations led for most of the works since 1976 reveals that, in some cases, the use of sophisticated implements combined with modifications of equipments and procedures may bring appreciable savings on doses during normal operation as well as maintenance and refuelings shut-down. However, the study gives the 'reasonably achievable' limits than can be aimed in a plant on operation, the doses resulting mainly from problems that should be taken into account at design [fr

  8. Web analytics tools and web metrics tools: An overview and comparative analysis

    Directory of Open Access Journals (Sweden)

    Ivan Bekavac

    2015-10-01

    Full Text Available The aim of the paper is to compare and analyze the impact of web analytics tools for measuring the performance of a business model. Accordingly, an overview of web analytics and web metrics tools is given, including their characteristics, main functionalities and available types. The data acquisition approaches and proper choice of web tools for particular business models are also reviewed. The research is divided in two sections. First, a qualitative focus is placed on reviewing web analytics tools to exploring their functionalities and ability to be integrated into the respective business model. Web analytics tools support the business analyst’s efforts in obtaining useful and relevant insights into market dynamics. Thus, generally speaking, selecting a web analytics and web metrics tool should be based on an investigative approach, not a random decision. The second section is a quantitative focus shifting from theory to an empirical approach, and which subsequently presents output data resulting from a study based on perceived user satisfaction of web analytics tools. The empirical study was carried out on employees from 200 Croatian firms from either an either IT or marketing branch. The paper contributes to highlighting the support for management that available web analytics and web metrics tools available on the market have to offer, and based on the growing needs of understanding and predicting global market trends.

  9. An analytical model for the performance analysis of concurrent transmission in IEEE 802.15.4.

    Science.gov (United States)

    Gezer, Cengiz; Zanella, Alberto; Verdone, Roberto

    2014-03-20

    Interference is a serious cause of performance degradation for IEEE802.15.4 devices. The effect of concurrent transmissions in IEEE 802.15.4 has been generally investigated by means of simulation or experimental activities. In this paper, a mathematical framework for the derivation of chip, symbol and packet error probability of a typical IEEE 802.15.4 receiver in the presence of interference is proposed. Both non-coherent and coherent demodulation schemes are considered by our model under the assumption of the absence of thermal noise. Simulation results are also added to assess the validity of the mathematical framework when the effect of thermal noise cannot be neglected. Numerical results show that the proposed analysis is in agreement with the measurement results on the literature under realistic working conditions.

  10. Analytic Hierarchy and Economic Analysis of a Plasma Gasification System for Naval Air Station Oceana-Dam Neck

    Science.gov (United States)

    2014-08-30

    fixed-bed gasification occur in the waste column, and finally produces a combustible gas mixture known as syngas . The main combustible species in...Old Dominion University Engineering Management and Systems Engineering Department ENMA 605 Program Capstone Final Project Analytic...Hierarchy and Economic Analysis of a Plasma Gasification System for Naval Air Station Oceana-Dam Neck Matthew R. Yost Report

  11. A comparison of analytic hierarchy process and conjoint analysis methods in assessing treatment alternatives for stroke rehabilitation

    NARCIS (Netherlands)

    IJzerman, Maarten Joost; van Til, Janine Astrid; Bridges, John

    2012-01-01

    Background: With growing emphasis on patient involvement in health technology assessment, there is a need for scientific methods that formally elicit patient preferences. Analytic hierarchy process (AHP) and conjoint analysis (CA) are two established scientific methods – albeit with very different

  12. moocRP: Enabling Open Learning Analytics with an Open Source Platform for Data Distribution, Analysis, and Visualization

    Science.gov (United States)

    Pardos, Zachary A.; Whyte, Anthony; Kao, Kevin

    2016-01-01

    In this paper, we address issues of transparency, modularity, and privacy with the introduction of an open source, web-based data repository and analysis tool tailored to the Massive Open Online Course community. The tool integrates data request/authorization and distribution workflow features as well as provides a simple analytics module upload…

  13. Low Complexity Precoder and Receiver Design for Massive MIMO Systems: A Large System Analysis using Random Matrix Theory

    KAUST Repository

    Sifaou, Houssem

    2016-05-01

    Massive MIMO systems are shown to be a promising technology for next generations of wireless communication networks. The realization of the attractive merits promised by massive MIMO systems requires advanced linear precoding and receiving techniques in order to mitigate the interference in downlink and uplink transmissions. This work considers the precoder and receiver design in massive MIMO systems. We first consider the design of the linear precoder and receiver that maximize the minimum signal-to-interference-plus-noise ratio (SINR) subject to a given power constraint. The analysis is carried out under the asymptotic regime in which the number of the BS antennas and that of the users grow large with a bounded ratio. This allows us to leverage tools from random matrix theory in order to approximate the parameters of the optimal linear precoder and receiver by their deterministic approximations. Such a result is of valuable practical interest, as it provides a handier way to implement the optimal precoder and receiver. To reduce further the complexity, we propose to apply the truncated polynomial expansion (TPE) concept on a per-user basis to approximate the inverse of large matrices that appear on the expressions of the optimal linear transceivers. Using tools from random matrix theory, we determine deterministic approximations of the SINR and the transmit power in the asymptotic regime. Then, the optimal per-user weight coe cients that solve the max-min SINR problem are derived. The simulation results show that the proposed precoder and receiver provide very close to optimal performance while reducing signi cantly the computational complexity. As a second part of this work, the TPE technique in a per-user basis is applied to the optimal linear precoding that minimizes the transmit power while satisfying a set of target SINR constraints. Due to the emerging research eld of green cellular networks, such a problem is receiving increasing interest nowadays. Closed

  14. Quantitative NMR of quadrupolar nucleus as a novel analytical method: hydrolysis behaviour analysis of aluminum ion.

    Science.gov (United States)

    Maki, Hideshi; Sakata, Genki; Mizuhata, Minoru

    2017-05-21

    In this study, quantitative nuclear magnetic resonance (qNMR) spectroscopy of quadrupolar nuclei has been established. The complicated hydrolysis behavior of the Al 3+ ion, which causes fish poisoning and inhibits the growth of plants in environmental water, was clarified by 27 Al qNMR spectroscopy. Highly accurate simultaneous multicomponent quantitative analysis of various hydrolyzed forms of the Al ion was achieved in a non-destructive manner. The calibration curve of the external standard aqueous Al(NO 3 ) 3 solution showed excellent linearity over a very wide concentration range from 1 × 10 -4 to 1 mol L -1 (an increase in concentration of 10 000 times), with a simple experimental and analytical procedure. Furthermore, the weaknesses of the conventional Ferron assay and the advantages of 27 Al qNMR spectroscopy were considered. The quantitative determination error for the free [Al(H 2 O) 6 ] 3+ ion and the trinuclear complex, which has a high complexation rate, is higher in the Ferron assay than in the 27 Al qNMR technique. The concentrations of four Al species were directly determined by 27 Al qNMR, namely, free [Al(H 2 O) 6 ] 3+ , the trinuclear complex, Al(OH) 4 - , and tridecameric hydrolyzed Al, which has a Keggin structure. The concentration of the tridecamer rapidly increased until 100 min after NaOH addition, and showed a local maximum after 1 week. In addition, the concentration of colloidal Al hydroxide, which cannot be detected by NMR spectroscopy, was determined by numerical analysis. This species was generated in the initial stage of reaction, and then the tridecamer formed very slowly.

  15. A Comparative Analysis of CMUT Receiving Architectures for the Design Optimization of Integrated Transceiver Front Ends.

    Science.gov (United States)

    Sautto, Marco; Savoia, Alessandro Stuart; Quaglia, Fabio; Caliano, Giosue; Mazzanti, Andrea

    2017-05-01

    A formal comparison between fundamental RX amplifier configurations for capacitive micromachined ultrasonic transducers (CMUTs) is proposed in this paper. The impact on both RX and the pulse-echo frequency response and on the output SNR is thoroughly analyzed and discussed. It is shown that the resistive-feedback amplifier yields a bandpass RX frequency response, while both open-loop voltage and capacitive-feedback amplifiers exhibit a low-pass frequency response. For a given power dissipation, it is formally proved that a capacitive-feedback amplifier provides a remarkable SNR improvement against the commonly adopted resistive feedback stage, achieved at the expense of a reduced pulse-echo center frequency, making its use convenient in low-frequency and midfrequency ultrasound imaging applications. The advantage mostly comes from a much lower noise contributed by the active devices, especially with low- Q , broadband transducers. The results of the analysis are applied to the design of a CMUT front end in BIPOLAR-CMOS-DMOS Silicon-on-Insulator technology operating at 10-MHz center frequency. It comprises a low-power RX amplifier, a high-voltage Transmission/Reception switch, and a 100-V TX driver. Extensive electrical characterization, pulse-echo measurements, and imaging results are shown. Compared with previously reported CMUT front ends, this transceiver demonstrates the highest dynamic range and state-of-the-art noise performance with an RX amplifier power dissipation of 1 mW.

  16. THE USE OF THE PATENT ANALYSIS METHOD FOR FINDING ANALOGUES AND PROTOTYPES OF RECEIVED TECHNICAL SOLUTIONS

    Directory of Open Access Journals (Sweden)

    Irina Petrova

    2016-03-01

    Full Text Available The research deals with the issue of the patent analysis efficiency, which is a necessary stage of seaching analogues and prototypes to obtain technical solutions. The article presents the results of analyzing the present automation systems for finding necessary information in the patent databases and identifies their advantages and disadvantages. It gives a description of the “Intellect” system, which is an example of software systems for the conceptual design stage support. Materials and Methods The article presents some of the possible ways to organize the patents-analogues search process and specific features of searching analogues and prototypes for the generated parametric structure scheme of the technical solution, which is the result of the synthesis of a new information-measuring and control system element in the “Intellect” system. The description of the proposed search query forming method is given. The article gives the structure of the patent passport, which must be stored in a database to organize the process of searcing analogues and prototypes. There given a description of algorithms for automatic adding a patent to the database, recalculating the weights while adding a patent by experts, identifying the fact of using different physical and technical effects in a patent. Results The final part of the article contains an example of the results of testing the developed subsystem implementing the proposed method. According to the test results it is concluded that the selected software and algorithmic solutions are effective.

  17. IoT Big-Data Centred Knowledge Granule Analytic and Cluster Framework for BI Applications: A Case Base Analysis

    OpenAIRE

    Chang, Hsien-Tsung; Mishra, Nilamadhab; Lin, Chung-Chih

    2015-01-01

    The current rapid growth of Internet of Things (IoT) in various commercial and non-commercial sectors has led to the deposition of large-scale IoT data, of which the time-critical analytic and clustering of knowledge granules represent highly thought-provoking application possibilities. The objective of the present work is to inspect the structural analysis and clustering of complex knowledge granules in an IoT big-data environment. In this work, we propose a knowledge granule analytic and cl...

  18. Analytical sensitivity of rapid isotopic analysis of water by refractometry for monitoring D2O concentration in nuclear reactor

    International Nuclear Information System (INIS)

    Dhole, K.; Tripathy, M.K.; Ghadigaonkar, R.D.; Datta, A.; Bose, H.; Roy, M.

    2011-01-01

    The feasibility of refractometry for rapid measurement of D 2 O (heavy water) concentration has been studied. Refractometry has been utilised to be an excellent analytical technique to quickly and non-invasively determine D 2 O concentration in water samples without using any chemical reagents. The measurement of refractive index property of water samples with use of temperature control has been utilized for the purpose of their quantitative analysis. The calibration performance provided a reasonable analytical sensitivity of this technique in the 1-100% D 2 O range. (author)

  19. Integrating agricultural research and policy analysis: analytical framework and policy applications for bio-economic modelling.

    NARCIS (Netherlands)

    Ruben, R.; Moll, H.; Kuyvenhoven, A.

    1998-01-01

    Interdisciplinary approaches to identify suitable incentives for enhancing sustainable natural resource use require an analytical framework that satisfies both practical purposes of policy support and disciplinary requirements regarding the specification of underlying technical and behavioural

  20. Numerical analysis of laser welding with consideration analytical methods of determining phase transformations and mechanical properties of welded joint

    Directory of Open Access Journals (Sweden)

    Piekarska Wiesława

    2018-01-01

    Full Text Available The numerical analysis of laser welding process with consideration analytical methods determining phase transformations and mechanical properties of welded joints are presents in this paper. The analytical CCT diagram and final structural composition of S355 steel are presented. The empirical relations presents in paper are determined by chemical compositions investigated steel and cooling rate between temperatures 800-500°C (t8/5. Phase composition and mechanical properties each of structures of steel in weld and heat affected zone (HAZ are determined on the basis of analytical methods. Laser welded flat is used in numerical simulations in ABAQUS. Mathematical modes of volumetric welding source are used in the calculations. Temperature fields, shape and size of melting zone for selected points in the cross-section of the joint are determined on the basis of thermal cycles obtained numerical.

  1. Management of mood and anxiety disorders in patients receiving opioid agonist therapy: Review and meta-analysis.

    Science.gov (United States)

    Hassan, Ahmed N; Howe, Aaron S; Samokhvalov, Andriy V; Le Foll, Bernard; George, Tony P

    2017-09-01

    Patients with opioid use disorders and mood and anxiety symptoms have a variable prognosis. Few randomized controlled trials (RCTs) have evaluated treatment of depression or anxiety in patients receiving opioid agonist therapies (OAT). This review evaluates studies of pharmacotherapy/psychotherapy for treating symptoms of depression or anxiety in patients receiving OAT. Public databases were searched for clinical trials of pharmacotherapy or psychotherapy for managing depression or anxiety symptoms in adults receiving OAT. Subsequently, we conducted a random effects meta-analysis model of RCTs by antidepressants subclasses. In our literature search, we identified 22 RCTs, eight of which were eligible for meta-analysis. Seven studies evaluated antidepressants in patients already maintained on OAT; two studies reported significant results for antidepressant effects versus placebo. Similarly, two of the seven studies that initiated antidepressants with OAT had advantages over placebo. Meta-analysis of grouped data revealed that tricyclic antidepressants (TCAs) (n = 235) significantly improved mean depression scores (SMD = -2.35, 95%CI: [-4.35, -0.34], z = -2.29, p = .022) while Selective Serotonin Reuptake Inhibitors (SSRIs) (n = 311) were not significantly different than placebo (SMD = 0.47, 95%CI: [-0.35, 1.30], z = 1.12, p = .263). Four out of five studies that implemented psychotherapeutic approaches reported a greater reduction of depressive symptoms than the comparison group. To date, psychotherapy has the most documented evidence for efficacy. TCAs appears effective but with more adverse effects than SSRIs. Further studies of OAT and adjunct antidepressant treatments for dual diagnosis patients are warranted. (Am J Addict 2017;26:551-563). © 2017 American Academy of Addiction Psychiatry.

  2. Microfluidic paper-based analytical devices for potential use in quantitative and direct detection of disease biomarkers in clinical analysis.

    Science.gov (United States)

    Lim, Wei Yin; Goh, Boon Tong; Khor, Sook Mei

    2017-08-15

    Clinicians, working in the health-care diagnostic systems of developing countries, currently face the challenges of rising costs, increased number of patient visits, and limited resources. A significant trend is using low-cost substrates to develop microfluidic devices for diagnostic purposes. Various fabrication techniques, materials, and detection methods have been explored to develop these devices. Microfluidic paper-based analytical devices (μPADs) have gained attention for sensing multiplex analytes, confirming diagnostic test results, rapid sample analysis, and reducing the volume of samples and analytical reagents. μPADs, which can provide accurate and reliable direct measurement without sample pretreatment, can reduce patient medical burden and yield rapid test results, aiding physicians in choosing appropriate treatment. The objectives of this review are to provide an overview of the strategies used for developing paper-based sensors with enhanced analytical performances and to discuss the current challenges, limitations, advantages, disadvantages, and future prospects of paper-based microfluidic platforms in clinical diagnostics. μPADs, with validated and justified analytical performances, can potentially improve the quality of life by providing inexpensive, rapid, portable, biodegradable, and reliable diagnostics. Copyright © 2017 Elsevier B.V. All rights reserved.

  3. Depth of the main crustal and mantle interfaces beneath the Gorely volcano (Kamchatka) based on the receiver function analysis

    Science.gov (United States)

    Ivanov, Arseny; Woelbern, Ingo; Nikulin, Alex; Koulakov, Ivan; Jakovlev, Andrey; Gordeev, Evgeny; Abkadyrov, Ilyas

    2016-04-01

    Gorely volcano is located in the southern part of the Kamchatka peninsula. It is two-tier structure with an old shield volcano at the base and a younger edifice on the top. The subducting Pacific oceanic Plate is located at the depth of 120 km beneath the volcano. The receiver function method was used to investigate the 1D structure beneath the volcano. From the continuous yearly seismograms recorded by a temporary network consisting of 16 seismic stations, we selected more than 600 records corresponding to teleseismic events which were used for the receiver function analysis. Based on the method by Zhu and Kanamory, we have determined the depth of the Moho interface at 38 km and that of the Conrad discontinuity at 26 km. These values correspond to the well exposed continental crust. The receiver functions also provide a rather prominent signal corresponding to a discontinuity at ~300 km depth; however, no clear signatures of deeper interfaces and slab interfaces are determined in this study. This study is the first attempt to determine the depth of the major interfaces beneath the Gorely volcano.

  4. Web Analytics

    Science.gov (United States)

    EPA’s Web Analytics Program collects, analyzes, and provides reports on traffic, quality assurance, and customer satisfaction metrics for EPA’s website. The program uses a variety of analytics tools, including Google Analytics and CrazyEgg.

  5. Investigation of Lab Fire Prevention Management System of Combining Root Cause Analysis and Analytic Hierarchy Process with Event Tree Analysis

    Directory of Open Access Journals (Sweden)

    Cheng-Chan Shih

    2016-01-01

    Full Text Available This paper proposed a new approach, combining root cause analysis (RCA, analytic hierarchy process (AHP, and event tree analysis (ETA in a loop to systematically evaluate various laboratory safety prevention strategies. First, 139 fire accidents were reviewed to identify the root causes and draw out prevention strategies. Most fires were caused due to runaway reactions, operation error and equipment failure, and flammable material release. These mostly occurred in working places of no prompt fire protection. We also used AHP to evaluate the priority of these strategies and found that chemical fire prevention strategy is the most important control element, and strengthening maintenance and safety inspection intensity is the most important action. Also together with our surveys results, we proposed that equipment design is also critical for fire prevention. Therefore a technical improvement was propounded: installing fire detector, automatic sprinkler, and manual extinguisher in the lab hood as proactive fire protections. ETA was then used as a tool to evaluate laboratory fire risks. The results indicated that the total risk of a fire occurring decreases from 0.0351 to 0.0042 without/with equipment taking actions. Establishing such system can make Environment, Health and Safety (EH&S office not only analyze and prioritize fire prevention policies more practically, but also demonstrate how effective protective equipment improvement can achieve and the probabilities of the initiating event developing into a serious accident or controlled by the existing safety system.

  6. An open-source analytical platform for analysis of C. elegans swimming-induced paralysis.

    Science.gov (United States)

    Hardaway, J Andrew; Wang, Jing; Fleming, Paul A; Fleming, Katherine A; Whitaker, Sarah M; Nackenoff, Alex; Snarrenberg, Chelsea L; Hardie, Shannon L; Zhang, Bing; Blakely, Randy D

    2014-07-30

    The nematode Caenhorhabditis elegans offers great power for the identification and characterization of genes that regulate behavior. In support of this effort, analytical methods are required that provide dimensional analyses of subcomponents of behavior. Previously, we demonstrated that loss of the presynaptic dopamine (DA) transporter, dat-1, evokes DA-dependent Swimming-Induced Paralysis (Swip) (Mcdonald et al., 2007), a behavior compatible with forward genetic screens (Hardaway et al., 2012). Here, we detail the development and implementation of SwimR, a set of tools that provide for an automated, kinetic analysis of C. elegans Swip. SwimR relies on open source programs that can be freely implemented and modified. We show that SwimR can display time-dependent alterations of swimming behavior induced by drug-treatment, illustrating this capacity with the dat-1 blocker and tricyclic antidepressant imipramine (IMI). We demonstrate the capacity of SwimR to extract multiple kinetic parameters that are impractical to obtain in manual assays. Standard measurements of C. elegans swimming utilizes manual assessments of the number of animals exhibiting swimming versus paralysis. Our approach deconstructs the time course and rates of movement in an automated fashion, offering a significant increase in the information that can be obtained from swimming behavior. The SwimR platform is a powerful tool for the deconstruction of worm thrashing behavior in the context of both genetic and pharmacological manipulations that can be used to segregate pathways that underlie nematode swimming mechanics. Copyright © 2014 Elsevier B.V. All rights reserved.

  7. Xenon spatial oscillation in nuclear power reactors:an analytical approach through non linear modal analysis

    International Nuclear Information System (INIS)

    Suarez Antola, R.

    2005-01-01

    It was proponed recently to apply an extension of Lyapunov's first method to the non-linear regime, known as non-linear modal analysis (NMA), to the study of space-time problems in nuclear reactor kinetics, nuclear power plant dynamics and nuclear power plant instrumentation and control(1). The present communication shows how to apply NMA to the study of Xenon spatial oscillations in large nuclear reactors. The set of non-linear modal equations derived by J. Lewins(2) for neutron flux, Xenon concentration and Iodine concentration are discussed, and a modified version of these equations is taken as a starting point. Using the methods of singular perturbation theory a slow manifold is constructed in the space of mode amplitudes. This allows the reduction of the original high dimensional dynamics to a low dimensional one. It is shown how the amplitudes of the first mode for neutron flux field, temperature field and concentrations of Xenon and Iodine fields can have a stable steady state value while the corresponding amplitudes of the second mode oscillates in a stable limit cycle. The extrapolated dimensions of the reactor's core are used as bifurcation parameters. Approximate analytical formulae are obtained for the critical values of this parameters( below which the onset of oscillations is produced), for the period and for the amplitudes of the above mentioned oscillations. These results are applied to the discussion of neutron flux and temperature excursions in critical locations of the reactor's core. The results of NMA can be validated from the results obtained applying suitable computer codes, using homogenization theory(3) to link the complex heterogeneous model of the codes with the simplified mathematical model used for NMA

  8. Books Received

    Indian Academy of Sciences (India)

    Books Received. Challenge and Thrill of Pre-College. Mathematics. V Krishnamurthy et al. New Age International. 1996, Rs.220. Mathematics for Science. S M Uppal and H M Humphreys. New Age International. 1996, Rs.17S. Physics for Engineers. M R Srinivasan. New Age Publications. 1996. Statement about ownership ...

  9. Biomonitoring of air pollution in Jamaica through trace-element analysis of epiphytic plants using nuclear and related analytical techniques

    International Nuclear Information System (INIS)

    Vutchkov, Mitko

    2001-01-01

    The main goal of the Coordinated Research Project (No:9937/R0), entitled 'Biomonitoring of Air Pollution in Jamaica Through Trace-Element Analysis of Epiphytic Plants Using Nuclear and Related Analytical Techniques', is to identify and validate site specific epiphytic plants for biomonitoring the atmospheric pollution in Jamaica using nuclear analytical techniques at the International Centre for Environmental and Nuclear Sciences (ICENS). The specific objectives for the second year of the project were: Development of HOP for sampling epiphytic plants in Jamaica; Sampling design and sample collection; Sample preparation and analysis; Development of an in-house SRM and participation in the NAT-5 inter-laboratory study; Data analysis and interpretation of the results; Development of a work plan of the third year of the project

  10. Clustering in analytical chemistry.

    Science.gov (United States)

    Drab, Klaudia; Daszykowski, Michal

    2014-01-01

    Data clustering plays an important role in the exploratory analysis of analytical data, and the use of clustering methods has been acknowledged in different fields of science. In this paper, principles of data clustering are presented with a direct focus on clustering of analytical data. The role of the clustering process in the analytical workflow is underlined, and its potential impact on the analytical workflow is emphasized.

  11. Value of the free light chain analysis in the clinical evaluation of response in multiple myeloma patients receiving anti-myeloma therapy

    DEFF Research Database (Denmark)

    Toftmann Hansen, Charlotte; Pedersen, Per T.; Jensen, Bo Amdi

    Value of the free light chain analysis in the clinical evaluation of response in multiple myeloma patients receiving anti-myeloma therapy.......Value of the free light chain analysis in the clinical evaluation of response in multiple myeloma patients receiving anti-myeloma therapy....

  12. A meta-analysis of mortality in end-stage renal disease patients receiving implantable cardioverter defibrillators (ICDs.

    Directory of Open Access Journals (Sweden)

    Tien-Hsing Chen

    Full Text Available Data on the effectiveness of implantable implantable cardioverter defibrillators (ICDs with respect to reducing mortality in patients with chronic kidney disease (CKD and end-stage renal disease (ESRD are lacking. The purpose of this meta-analysis was to compare the mortality of patients with ESRD who have received and not received an ICD. A search was conducted on January 31, 2013 of Medline, Cochrane, EMBASE, and Google Scholar. Studies were selected for inclusion based on the following criteria. 1 Randomized controlled trial. 2 ESRD patients with heart failure. 3 Device therapy (ICD, CRT-defibrillator [CRT-D] used to treat heart failure. 4 Primary outcome is survival analysis. 5 Retrospective study if survival analysis was performed. The primary outcome was overall survival (OS, and the secondary outcome was 2-year survival. Odds ratios (ORs with 95% confidence intervals (CI were calculated, and a χ2-based test of homogeneity was performed. Three studies were included in the analysis. The combined OR for OS was 2.245 (95% CI 1.871 to 2.685, P<0.001, indicating that patients with an ICD had a significantly higher OS than those without an ICD. The combined OR for 2-year survival was 2.312 (95% CI 1.921 to 2.784, P<0.001, indicating that patients with an ICD had a significantly higher 2-year survival rate than those without an ICD. The use of ICD in patients with ESRD is associated with an increase in the OS and the 2-year survival rate.

  13. Propulsion and launching analysis of variable-mass rockets by analytical methods

    Directory of Open Access Journals (Sweden)

    D.D. Ganji

    2013-09-01

    Full Text Available In this study, applications of some analytical methods on nonlinear equation of the launching of a rocket with variable mass are investigated. Differential transformation method (DTM, homotopy perturbation method (HPM and least square method (LSM were applied and their results are compared with numerical solution. An excellent agreement with analytical methods and numerical ones is observed in the results and this reveals that analytical methods are effective and convenient. Also a parametric study is performed here which includes the effect of exhaust velocity (Ce, burn rate (BR of fuel and diameter of cylindrical rocket (d on the motion of a sample rocket, and contours for showing the sensitivity of these parameters are plotted. The main results indicate that the rocket velocity and altitude are increased with increasing the Ce and BR and decreased with increasing the rocket diameter and drag coefficient.

  14. Experimental Design and Data Analysis in Receiver Operating Characteristic Studies: Lessons Learned from Reports in Radiology from 1997 to 20061

    Science.gov (United States)

    Shiraishi, Junji; Pesce, Lorenzo L.; Metz, Charles E.; Doi, Kunio

    2009-01-01

    Purpose: To provide a broad perspective concerning the recent use of receiver operating characteristic (ROC) analysis in medical imaging by reviewing ROC studies published in Radiology between 1997 and 2006 for experimental design, imaging modality, medical condition, and ROC paradigm. Materials and Methods: Two hundred ninety-five studies were obtained by conducting a literature search with PubMed with two criteria: publication in Radiology between 1997 and 2006 and occurrence of the phrase “receiver operating characteristic.” Studies returned by the query that were not diagnostic imaging procedure performance evaluations were excluded. Characteristics of the remaining studies were tabulated. Results: Two hundred thirty-three (79.0%) of the 295 studies reported findings based on observers' diagnostic judgments or objective measurements. Forty-three (14.6%) did not include human observers, with most of these reporting an evaluation of a computer-aided diagnosis system or functional data obtained with computed tomography (CT) or magnetic resonance (MR) imaging. The remaining 19 (6.4%) studies were classified as reviews or meta-analyses and were excluded from our subsequent analysis. Among the various imaging modalities, MR imaging (46.0%) and CT (25.7%) were investigated most frequently. Approximately 60% (144 of 233) of ROC studies with human observers published in Radiology included three or fewer observers. Conclusion: ROC analysis is widely used in radiologic research, confirming its fundamental role in assessing diagnostic performance. However, the ROC studies reported in Radiology were not always adequate to support clear and clinically relevant conclusions. © RSNA, 2009 Supplemental material: http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.2533081632/-/DC1 PMID:19864510

  15. Policy-Making Theory as an Analytical Framework in Policy Analysis: Implications for Research Design and Professional Advocacy.

    Science.gov (United States)

    Sheldon, Michael R

    2016-01-01

    Policy studies are a recent addition to the American Physical Therapy Association's Research Agenda and are critical to our understanding of various federal, state, local, and organizational policies on the provision of physical therapist services across the continuum of care. Policy analyses that help to advance the profession's various policy agendas will require relevant theoretical frameworks to be credible. The purpose of this perspective article is to: (1) demonstrate the use of a policy-making theory as an analytical framework in a policy analysis and (2) discuss how sound policy analysis can assist physical therapists in becoming more effective change agents, policy advocates, and partners with other relevant stakeholder groups. An exploratory study of state agency policy responses to address work-related musculoskeletal disorders is provided as a contemporary example to illustrate key points and to demonstrate the importance of selecting a relevant analytical framework based on the context of the policy issue under investigation. © 2016 American Physical Therapy Association.

  16. Band structure analysis of an analytically solvable Hill equation with continuous potential

    Science.gov (United States)

    Morozov, G. V.; Sprung, D. W. L.

    2015-03-01

    This paper concerns analytically solvable cases of Hill’s equation containing a continuously differentiable periodic potential. We outline a procedure for constructing the Floquet-Bloch fundamental system, and analyze the band structure of the system. The similarities to, and differences from, the cases of a piecewise constant periodic potential and the Mathieu potential, are illuminated.

  17. Innovative methods for data analysis in analytical chemistry using Bayesian statistics and machine learning

    NARCIS (Netherlands)

    Woldegebriel, M.T.

    2017-01-01

    In analytical chemistry, rapid advancement in instrumentation, especially in high resolution mass-spectrometry is making a significant contribution for further developments of the field. As such, in separation science, nowadays, several hyphenated techniques have proven to be the state-of-the-art

  18. Methods for Integrating Moderation and Mediation: A General Analytical Framework Using Moderated Path Analysis

    Science.gov (United States)

    Edwards, Jeffrey R.; Lambert, Lisa Schurer

    2007-01-01

    Studies that combine moderation and mediation are prevalent in basic and applied psychology research. Typically, these studies are framed in terms of moderated mediation or mediated moderation, both of which involve similar analytical approaches. Unfortunately, these approaches have important shortcomings that conceal the nature of the moderated…

  19. Stress analysis of fatigue cracks in mechanically fastened joints : An analytical and experimental investigation

    NARCIS (Netherlands)

    De Rijck, J.J.M.

    2005-01-01

    The two historical fuselage failures, Comet in 1954 and Aloha in 1988, illustrate that similar accidents must be avoided which requires a profound understanding of the fatigue mechanisms involved, including analytical models to predict the fatigue behavior of riveted joints of a fuselage structure.

  20. Analytic-Approximate Solution For An Integro- Differential Equation Arising In Oscillating Magnetic Fields Using Homotopy Analysis Method

    OpenAIRE

    H. Saberi-Nik; S. Effati; R. Buzhabadi

    2010-01-01

    In this paper, we give an analytical approximate solution for an integro- differential equation which describes the charged particle motion for certain configurations of oscillating magnetic fields is considered. The homotopy analysis method (HAM) is used for solving this equation. Several examples are given to reconfirm the efficiency of these algorithms. The results of applying this procedure to the integro-differential equation with time-periodic coefficients show the high accuracy, simpli...

  1. Analytic-Approximate Solution For An Integro- Differential Equation Arising In Oscillating Magnetic Fields Using Homotopy Analysis Method

    Directory of Open Access Journals (Sweden)

    H. Saberi-Nik

    2013-07-01

    Full Text Available In this paper, we give an analytical approximate solution for an integro- differential equation which describes the charged particle motion for certain configurations of oscillating magnetic fields is considered. The homotopy analysis method (HAM is used for solving this equation. Several examples are given to reconfirm the efficiency of these algorithms. The results of applying this procedure to the integro-differential equation with time-periodic coefficients show the high accuracy, simplicity and efficiency of this method.

  2. Analytic-Approximate Solution For An Integro- Differential Equation Arising In Oscillating Magnetic Fields Using Homotopy Analysis Method

    Directory of Open Access Journals (Sweden)

    H. Saberi-Nik

    2010-06-01

    Full Text Available In this paper, we give an analytical approximate solution for an integro- differential equation which describes the charged particle motion for certain configurations of oscillating magnetic fields is considered. The homotopy analysis method (HAM is used for solving this equation. Several examples are given to reconfirm the efficiency of these algorithms. The results of applying this procedure to the integro-differential equation with time-periodic coefficients show the high accuracy, simplicity and efficiency of this method.

  3. Analysis and proposal of solutions to optimize service process in the company Analytical Medical Instruments, Ltd. (AMI, Ltd.)

    OpenAIRE

    Kolář, Michal

    2014-01-01

    The work is focused on the analysis of the service process in the company Analytical Medical Instruments Ltd. (hereinafter the firm AMI, Ltd.), and subsequent optimization of the service process . The main objective is service process to analyze and propose a solution that would optimize the service process . The first part is theoretical , includes a search of the sources and methodologies. Then I described the company AMI, Ltd. The second part is based on a brief description of the organiza...

  4. A Novel WPT System Based on Dual Transmitters and Dual Receivers for High Power Applications: Analysis, Design and Implementation

    Directory of Open Access Journals (Sweden)

    Yong Li

    2017-02-01

    Full Text Available Traditional Wireless Power Transfer (WPT systems only have one energy transmission path, which can hardly meet the power demand for high power applications, e.g., railway applications (electric trains and trams, etc. due to the capacity constraints of power electronic devices. A novel WPT system based on dual transmitters and dual receivers is proposed in this paper to upgrade the power capacity of the WPT system. The reliability and availability of the proposed WPT system can be dramatically improved due to the four energy transmission paths. A three-dimensional finite element analysis (FEA tool ANSYS MAXWELL (ANSYS, Canonsburg, PA, USA is adopted to investigate the proposed magnetic coupling structure. Besides, the effects of the crossing coupling mutual inductances among the transmitters and receivers are analyzed. It shows that the same-side cross couplings will decrease the efficiency and transmitted power. Decoupling transformers are employed to mitigate the effects of the same-side cross couplings. Meanwhile, the output voltage in the secondary side can be regulated at its designed value with a fast response performance, and the system can continue work even with a faulty inverter. Finally, a scale-down experimental setup is provided to verify the proposed approach. The experimental results indicate that the proposed method could improve the transmitted power capacity, overall efficiency and reliability, simultaneously. The proposed WPT structure is a potential alternative for high power applications.

  5. Survival Advantage Associated with Metformin Usage in Hepatocellular Carcinoma Patients Receiving Radiotherapy: A Propensity Score Matching Analysis.

    Science.gov (United States)

    Jang, Won Il; Kim, Mi-Sook; Lim, Jung Sub; Yoo, Hyung Jun; Seo, Young Seok; Han, Chul Ju; Park, Su Cheol; Kay, Chul Seung; Kim, Myungsoo; Jang, Hong Seok; Lee, Dong Soo; Chang, Ah Ram; Park, Hae Jin

    2015-09-01

    The present study aimed to evaluate the effects of metformin on the clinical outcomes of patients receiving radiotherapy for inoperable hepatocellular carcinoma. The medical records of 217 patients treated with stereotactic body or hypofractionated radiotherapy for inoperable hepatocellular carcinoma were reviewed. Patients were divided into the metformin group (n=19) and the non-metformin group (n=198), including those with diabetes (n=29), and those without (n=169). We performed a propensity score-matching analysis comparing the two groups. In the propensity score-matched cohort (n=76), the overall survival rate of the metformin group was higher than that of the non-metformin group (2-year, 76% vs. 37%, p=0.022). The adjusted Cox proportional hazards model revealed that metformin usage was a significant factor for mortality (adjusted hazard ratio=0.361; 95% confidence interval=0.139-0.935). The use of metformin in patients with hepatocellular carcinoma receiving radiotherapy was associated with higher overall survival. Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

  6. Imaging the deep structures of the convergent plates along the Ecuadorian subduction zone through receiver function analysis

    Science.gov (United States)

    Galve, A.; Charvis, P.; Regnier, M. M.; Font, Y.; Nocquet, J. M.; Segovia, M.

    2017-12-01

    The Ecuadorian subduction zone was affected by several large M>7.5 earthquakes. While we have low resolution on the 1942, 1958 earthquakes rupture zones extension, the 2016 Pedernales earthquake, that occurs at the same location than the 1942 earthquake, give strong constraints on the deep limit of the seismogenic zone. This downdip limit is caused by the onset of plasticity at a critical temperature (> 350-450 °C for crustal materials, or serpentinized mantle wedge, and eventually > 700 °C for dry mantle). However we still don't know exactly where is the upper plate Moho and therefore what controls the downdip limit of Ecuadorian large earthquakes seismogenic zone. For several years Géoazur and IG-EPN have maintained permanent and temporary networks (ADN and JUAN projects) along the margin to register the subduction zone seismological activity. Although Ecuador is not a good place to perform receiver function due to its position with respect to the worldwide teleseismic sources, the very long time deployment compensate this issue. We performed a frequency dependent receiver function analysis to derive (1) the thickness of the downgoing plate, (2) the interplate depth and (3) the upper plate Moho. These constraints give the frame to interpretation on the seismogenic zone of the 2016 Pedernales earthquake.

  7. Glycan characterization of the NIST RM monoclonal antibody using a total analytical solution: From sample preparation to data analysis.

    Science.gov (United States)

    Hilliard, Mark; Alley, William R; McManus, Ciara A; Yu, Ying Qing; Hallinan, Sinead; Gebler, John; Rudd, Pauline M

    Glycosylation is an important attribute of biopharmaceutical products to monitor from development through production. However, glycosylation analysis has traditionally been a time-consuming process with long sample preparation protocols and manual interpretation of the data. To address the challenges associated with glycan analysis, we developed a streamlined analytical solution that covers the entire process from sample preparation to data analysis. In this communication, we describe the complete analytical solution that begins with a simplified and fast N-linked glycan sample preparation protocol that can be completed in less than 1 hr. The sample preparation includes labelling with RapiFluor-MS tag to improve both fluorescence (FLR) and mass spectral (MS) sensitivities. Following HILIC-UPLC/FLR/MS analyses, the data are processed and a library search based on glucose units has been included to expedite the task of structural assignment. We then applied this total analytical solution to characterize the glycosylation of the NIST Reference Material mAb 8761. For this glycoprotein, we confidently identified 35 N-linked glycans and all three major classes, high mannose, complex, and hybrid, were present. The majority of the glycans were neutral and fucosylated; glycans featuring N-glycolylneuraminic acid and those with two galactoses connected via an α1,3-linkage were also identified.

  8. The production performance of lactating Jersey cows receiving ...

    African Journals Online (AJOL)

    Unknown

    Increasing the protein concentration ... objectives of this study were to determine the production performance of lactating dairy cows receiving varying .... protein production. References. AOAC, 1990. Association of analytical chemists. Official Methods of Analysis. 15th ed., Washington, D.C. Browne, I., Allen, D., Phipps, ...

  9. Cost analysis of an air Brayton receiver for a solar thermal electric power system in selected annual production volumes

    Science.gov (United States)

    1981-12-01

    Pioneer Engineering and Manufacturing Company estimated the cost of manufacturing and Air Brayton Receiver for a Solar Thermal Electric Power System as designed by the AiResearch Division of the Garrett Corporation. Production costs were estimated at annual volumes of 100; 1,000; 5,000; 10,000; 50,000; 100,000 and 1,000,000 units. These costs included direct labor, direct material and manufacturing burden. A make or buy analysis was made of each part of each volume. At high volumes special fabrication concepts were used to reduce operation cycle times. All costs were estimated at an assumed 100% plant capacity. Economic feasibility determined the level of production at which special concepts were to be introduced. Estimated costs were based on the economics of the last half of 1980. Tooling and capital equipment costs were estimated for ach volume. Infrastructure and personnel requirements were also estimated.

  10. Integrated Data Collection Analysis (IDCA) Program — KClO3 (as received)/Icing Sugar

    Energy Technology Data Exchange (ETDEWEB)

    Sandstrom, Mary M. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Brown, Geoffrey W. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Preston, Daniel N. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Pollard, Colin J. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Warner, Kirstin F. [Naval Surface Warfare Center (NSWC IHD), Indian Head, MD (United States). Indian Head Division; Sorenson, Daniel N. [Naval Surface Warfare Center (NSWC IHD), Indian Head, MD (United States). Indian Head Division; Remmers, Daniel L. [Naval Surface Warfare Center (NSWC IHD), Indian Head, MD (United States). Indian Head Division; Shelley, Timothy J. [Air Force Research Lab. (AFRL/RXQL), Tyndall AFB, FL (United States); Reyes, Jose A. [Applied Research Associates, Inc., Tyndall AFB, FL (United States); Hsu, Peter C. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Whipple, Richard E. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Reynolds, John G. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2011-05-23

    The Integrated Data Collection Analysis (IDCA) program is conducting a proficiency study for Small-Scale Safety and Thermal (SSST) testing of homemade explosives (HMEs). Described here are the results for impact, friction, electrostatic discharge, and differential scanning calorimetry analysis of a mixture of KClO3 as received from the manufacturer mixed with icing sugar, sized through a 100-mesh sieve—KClO3/icing sugar (AR) mixture. This material was selected because of the challenge of performing SSST testing of a mixture of two solid materials. The mixture was found to: 1) be more sensitive to impact than RDX, similar to PETN, 2) be the same or less sensitive to friction than PETN, and 3) to be less sensitive to spark than RDX. The thermal analysis showed that the mixture has thermally stability similar to RDX and is perhaps more energetic upon decomposition but variable results indicate sampling issues. Compared to the 100-mesh sieved counter part, the KClO3/icing sugar (-100) mixture, the AR mixture was found to be about the same sensitivity towards impact, friction and ESD.

  11. The chemical speciation and analysis of trace elements in sediment with Neutron Activation Analytical method(NAA) and atomic mass spectrometry

    International Nuclear Information System (INIS)

    Nam, Sang-Ho; Kim, Jae-Jin; Chung, Yong-Sam; Kim, Sun-Ha

    2003-01-01

    In this research, first of all, the analytical methods for the determination of major elements in sediment have been developed with ICP-MS (Inductively Coupled Plasma Mass Spectrometry). The analytical results of major elements (Al, Ca, K, Fe, Mg) with Cool ICP-MS were much better than those with normal ICP-MS. The analytical results were compared with those of NAA (Neutron Activation Analysis). NAA were a little superior to ICP-MS for the determination of major elements in sediment as a non-destructive trace analytical trace analytical method. The analytical methods for the determination of minor elements (Cr, Ce, U, Co, Pb, As, Se) have been also developed with ICP-MS. The analytical results by standard calibration curve with ICP-MS were not accurate due to the matrix interferences. Thus, the internal standard method was applied, then the analytical results for minor elements with ICP-MS were greatly improved. The analytical results obtained by ICP-MS were compared with those obtained by NAA. It showed that the two analytical methods have great capabilities for the determination of minor elements in sediments. Accordingly, the NAA will plan an important role in analysis of environment sample with complex matrix. ICP-MS also will play an important role because it has a great capability for the determination of Pb that could not be determined by NAA

  12. Thermal performance prediction and sensitivity analysis for future deployment of molten salt cavity receiver solar power plants in Algeria

    International Nuclear Information System (INIS)

    Boudaoud, S.; Khellaf, A.; Mohammedi, K.; Behar, O.

    2015-01-01

    Highlights: • Performance of power plant with molten salt cavity receiver is assessed. • A method has been used to optimize the plant solar multiple, capacity factor and LEC. • Comparison of the simulated results to those of PS20 has shown good agreement. • Higher fossil fuel fraction reduces the LEC and increases the capacity factor. • Highland and Sahara regions are suitable for CRS plants deployment. - Abstract: Of all Concentrating Solar Power (CSP) technologies available today, the molten salt solar power plant appears to be the most important option for providing a major share of the clean and renewable electricity needed in the future. In the present paper, a technical and economic analysis for the implementation of a probable molten salt cavity receiver thermal power plant in Algeria has been carried out. In order to do so, we have investigated the effect of solar field size, storage capacity factor, solar radiation intensity, hybridization and power plant capacity on the thermal efficiency and electricity cost of the selected plant. The system advisor model has been used to perform the technical performance and the economic assessment for different locations (coastal, highland and Sahara regions) in Algeria. Taking into account various factors, a method has been applied to optimize the solar multiple and the capacity factor of the plant, to get a trade-off between the incremental investment costs of the heliostat field and the thermal energy storage. The analysis has shown that the use of higher fossil fuel fraction significantly reduces the levelized electricity cost (LEC) and sensibly increases the capacity factor (CF). The present study indicates that hybrid molten salt solar tower power technology is very promising. The CF and the LEC have been found to be respectively of the order of 71% and 0.35 $/kW e . For solar-only power plants, these parameters are respectively about 27% and 0.63 $/kW e . Therefore, hybrid central receiver systems are

  13. Hidden Markov model analysis reveals the advantage of analytic eye movement patterns in face recognition across cultures.

    Science.gov (United States)

    Chuk, Tim; Crookes, Kate; Hayward, William G; Chan, Antoni B; Hsiao, Janet H

    2017-12-01

    It remains controversial whether culture modulates eye movement behavior in face recognition. Inconsistent results have been reported regarding whether cultural differences in eye movement patterns exist, whether these differences affect recognition performance, and whether participants use similar eye movement patterns when viewing faces from different ethnicities. These inconsistencies may be due to substantial individual differences in eye movement patterns within a cultural group. Here we addressed this issue by conducting individual-level eye movement data analysis using hidden Markov models (HMMs). Each individual's eye movements were modeled with an HMM. We clustered the individual HMMs according to their similarities and discovered three common patterns in both Asian and Caucasian participants: holistic (looking mostly at the face center), left-eye-biased analytic (looking mostly at the two individual eyes in addition to the face center with a slight bias to the left eye), and right-eye-based analytic (looking mostly at the right eye in addition to the face center). The frequency of participants adopting the three patterns did not differ significantly between Asians and Caucasians, suggesting little modulation from culture. Significantly more participants (75%) showed similar eye movement patterns when viewing own- and other-race faces than different patterns. Most importantly, participants with left-eye-biased analytic patterns performed significantly better than those using either holistic or right-eye-biased analytic patterns. These results suggest that active retrieval of facial feature information through an analytic eye movement pattern may be optimal for face recognition regardless of culture. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. Hybrid stress and analytical functions for analysis of thin plates bending

    Directory of Open Access Journals (Sweden)

    Mohammad Rezaiee-Pajand

    Full Text Available In this paper, two efficient elements for analyzing thin plate bending are proposed. They are a triangular element (THS and a quadrilateral element (QHS, which have 9 and 12 degrees of freedom, respectively. Formulations of these elements are based on hybrid variational principle and analytical homogeneous solution of thin plate equation. Independent fields in hybrid functional are internal stress and boundary displacement field. The internal stress field has been calculated using analytical homogeneous solution and boundary field is related to the nodal degree of freedoms by the boundary interpolation functions. To calculate these functions, the edges of element are assumed to behave like an Euler-Bernoulli beam. The high accuracy and efficiency of the proposed elements are demonstrated in the severe tests.

  15. Free and Forced Vibration Analysis of an Infilled Steel Frame: Experimental, Numerical, and Analytical Methods

    Directory of Open Access Journals (Sweden)

    Mohammad Amin Hariri-Ardebili

    2014-01-01

    Full Text Available Structural frames with masonry infill panels make up a significant portion of the buildings constructed in earthquake-prone areas prior to the developing of the seismic design standards. In this paper, the effects of masonry panels on the vibration response of an infilled steel-frame building are investigated. Various ambient and steady state forced vibration tests are carried out to realize the dynamic characteristics of the system. 3D finite element models of the building with and without infill panels are provided based on marcomodeling theorem. A set of analytical approximate formulas are also derived to estimate the vibrational period. The natural frequencies of the building are computed using numerical, analytical, and experimental methods. The results show that neglecting the effect of infill panels leads to considerable error. Moreover, it is shown that there is good agreement among the results obtained by the three methods considering the effect of infill panels.

  16. An analytical model accounting for tip shape evolution during atom probe analysis of heterogeneous materials.

    Science.gov (United States)

    Rolland, N; Larson, D J; Geiser, B P; Duguay, S; Vurpillot, F; Blavette, D

    2015-12-01

    An analytical model describing the field evaporation dynamics of a tip made of a thin layer deposited on a substrate is presented in this paper. The difference in evaporation field between the materials is taken into account in this approach in which the tip shape is modeled at a mesoscopic scale. It was found that the non-existence of sharp edge on the surface is a sufficient condition to derive the morphological evolution during successive evaporation of the layers. This modeling gives an instantaneous and smooth analytical representation of the surface that shows good agreement with finite difference simulations results, and a specific regime of evaporation was highlighted when the substrate is a low evaporation field phase. In addition, the model makes it possible to calculate theoretically the tip analyzed volume, potentially opening up new horizons for atom probe tomographic reconstruction. Copyright © 2015 Elsevier B.V. All rights reserved.

  17. Nuclear analytical techniques for on-line elemental analysis in industry

    International Nuclear Information System (INIS)

    1988-06-01

    This report is the result of an advisory group meeting held in Espoo, Finland, 1-5 June, 1987. The purpose of the meeting was to assess the present status and development of nuclear analytical techniques used for industrial process control. The report gives an overview of the different nuclear techniques used for process control and the most important applications. A separate abstract was prepared for each of the 7 papers presented at the meeting. Refs, figs and tabs

  18. An analysis of basic design students' intuitive and analytic attitudes in colour decisions

    OpenAIRE

    Akbay, Saadet

    2003-01-01

    Cataloged from PDF version of article. Colour can be defined as a subjective preference, an experience and an intuitive sense, or as a theory and a science. Design education regards colour as a scientific theory by means of reasoning. The design students’ colour decisions, values, and intuitive attitudes are aimed to be developed and cultivated by colour education in basic design, and supported and equipped by knowledge towards analytical attitudes. Thus, the major concern o...

  19. IoT Big-Data Centred Knowledge Granule Analytic and Cluster Framework for BI Applications: A Case Base Analysis.

    Directory of Open Access Journals (Sweden)

    Hsien-Tsung Chang

    Full Text Available The current rapid growth of Internet of Things (IoT in various commercial and non-commercial sectors has led to the deposition of large-scale IoT data, of which the time-critical analytic and clustering of knowledge granules represent highly thought-provoking application possibilities. The objective of the present work is to inspect the structural analysis and clustering of complex knowledge granules in an IoT big-data environment. In this work, we propose a knowledge granule analytic and clustering (KGAC framework that explores and assembles knowledge granules from IoT big-data arrays for a business intelligence (BI application. Our work implements neuro-fuzzy analytic architecture rather than a standard fuzzified approach to discover the complex knowledge granules. Furthermore, we implement an enhanced knowledge granule clustering (e-KGC mechanism that is more elastic than previous techniques when assembling the tactical and explicit complex knowledge granules from IoT big-data arrays. The analysis and discussion presented here show that the proposed framework and mechanism can be implemented to extract knowledge granules from an IoT big-data array in such a way as to present knowledge of strategic value to executives and enable knowledge users to perform further BI actions.

  20. Two-Dimensional Model for Reactive-Sorption Columns of Cylindrical Geometry: Analytical Solutions and Moment Analysis.

    Science.gov (United States)

    Khan, Farman U; Qamar, Shamsul

    2017-05-01

    A set of analytical solutions are presented for a model describing the transport of a solute in a fixed-bed reactor of cylindrical geometry subjected to the first (Dirichlet) and third (Danckwerts) type inlet boundary conditions. Linear sorption kinetic process and first-order decay are considered. Cylindrical geometry allows the use of large columns to investigate dispersion, adsorption/desorption and reaction kinetic mechanisms. The finite Hankel and Laplace transform techniques are adopted to solve the model equations. For further analysis, statistical temporal moments are derived from the Laplace-transformed solutions. The developed analytical solutions are compared with the numerical solutions of high-resolution finite volume scheme. Different case studies are presented and discussed for a series of numerical values corresponding to a wide range of mass transfer and reaction kinetics. A good agreement was observed in the analytical and numerical concentration profiles and moments. The developed solutions are efficient tools for analyzing numerical algorithms, sensitivity analysis and simultaneous determination of the longitudinal and transverse dispersion coefficients from a laboratory-scale radial column experiment. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  1. IoT Big-Data Centred Knowledge Granule Analytic and Cluster Framework for BI Applications: A Case Base Analysis

    Science.gov (United States)

    Chang, Hsien-Tsung; Mishra, Nilamadhab; Lin, Chung-Chih

    2015-01-01

    The current rapid growth of Internet of Things (IoT) in various commercial and non-commercial sectors has led to the deposition of large-scale IoT data, of which the time-critical analytic and clustering of knowledge granules represent highly thought-provoking application possibilities. The objective of the present work is to inspect the structural analysis and clustering of complex knowledge granules in an IoT big-data environment. In this work, we propose a knowledge granule analytic and clustering (KGAC) framework that explores and assembles knowledge granules from IoT big-data arrays for a business intelligence (BI) application. Our work implements neuro-fuzzy analytic architecture rather than a standard fuzzified approach to discover the complex knowledge granules. Furthermore, we implement an enhanced knowledge granule clustering (e-KGC) mechanism that is more elastic than previous techniques when assembling the tactical and explicit complex knowledge granules from IoT big-data arrays. The analysis and discussion presented here show that the proposed framework and mechanism can be implemented to extract knowledge granules from an IoT big-data array in such a way as to present knowledge of strategic value to executives and enable knowledge users to perform further BI actions. PMID:26600156

  2. IoT Big-Data Centred Knowledge Granule Analytic and Cluster Framework for BI Applications: A Case Base Analysis.

    Science.gov (United States)

    Chang, Hsien-Tsung; Mishra, Nilamadhab; Lin, Chung-Chih

    2015-01-01

    The current rapid growth of Internet of Things (IoT) in various commercial and non-commercial sectors has led to the deposition of large-scale IoT data, of which the time-critical analytic and clustering of knowledge granules represent highly thought-provoking application possibilities. The objective of the present work is to inspect the structural analysis and clustering of complex knowledge granules in an IoT big-data environment. In this work, we propose a knowledge granule analytic and clustering (KGAC) framework that explores and assembles knowledge granules from IoT big-data arrays for a business intelligence (BI) application. Our work implements neuro-fuzzy analytic architecture rather than a standard fuzzified approach to discover the complex knowledge granules. Furthermore, we implement an enhanced knowledge granule clustering (e-KGC) mechanism that is more elastic than previous techniques when assembling the tactical and explicit complex knowledge granules from IoT big-data arrays. The analysis and discussion presented here show that the proposed framework and mechanism can be implemented to extract knowledge granules from an IoT big-data array in such a way as to present knowledge of strategic value to executives and enable knowledge users to perform further BI actions.

  3. Analytical and clinical performance of the epoc blood analysis system: experience at a large tertiary academic medical center.

    Science.gov (United States)

    Stotler, Brie A; Kratz, Alexander

    2013-11-01

    To describe validation and performance of epoc, a blood gas analysis point-of-care system, in a live clinical setting. Data were collected for 156 epoc systems over 12 months. Preimplementation precision and correlation studies and postimplementation quality assurance data were collected, including test card, reader, and personal data assistant (PDA) failure rates. The coefficient of variation was clinically acceptable for all analytes. Correlation studies yielded an R(2) from 0.901 (for sodium) to 0.994 (for potassium) with the Nova analyzer and from 0.961 (sodium) to 0.991 (glucose) with the i-STAT. Average test card failure rate was 13%. Of the PDA/reader units, 55% needed repair within 1 year. The analytical performance showed high precision and good correlation with the Nova and i-STAT platforms. Test card and instrument failure rates were higher than that of the i-STAT system.

  4. Comparison of the clinical informativeness of photographs and digital imaging media with multiple-choice receiver operating characteristic analysis.

    Science.gov (United States)

    Perednia, D A; Gaines, J A; Butruille, T W

    1995-03-01

    Electronic medical imaging is important for medical informatics, computerized learning, and especially for the growing field of telemedicine. The image resolution necessary for a clinical application can be determined by use of receiver operating characteristic (ROC) experiments. Completely profiling display systems is a tedious process, requiring multiple ROC experiments. We have developed a multiple-choice ROC analysis technique to compare the relative informativeness of digital image formats for a spectrum of cutaneous lesions simultaneously. The technique makes use of logical competitor sets (LCSs) of clinical conditions to redefine multiple-choice responses into the present/absent framework required for conventional ROC curve construction. The study divided 180 slides and digital images into three LCSs: pigmented lesions, flesh-colored papules, and papulosquamous conditions. Eight dermatologists diagnosed the lesions presented in two randomized viewing sessions. Accuracy profiles, independent of individual observer sensitivities, were derived from the responses. The informativeness of color slides and digital images was statistically similar, even when the conditions were stratified by difficulty of diagnosis. Results for nine specific skin conditions represented in the three LCSs were obtained simultaneously. Digital images appear to be as informative as slides for specific dermatologic diagnoses in the three LCSs tested. The use of LCSs allows stratification of results by diagnosis with greater efficiency than multiple repeated ROC experiments. Multiple-choice ROC analysis used in conjunction with logical competitor sets is the best currently available method for comparing imaging media for use in visual disciplines such as dermatology, radiology, pathology, and others.

  5. Safety analysis, 200 Area, Savannah River Plant: Separations area operations. Receiving Basin for Offsite Fuel (Supplement 3)

    Energy Technology Data Exchange (ETDEWEB)

    Allen, P M

    1983-09-01

    Analysis of the Savannah River Plant RBOF and RRF included an evaluation of the reliability of process equipment and controls, administrative controls, and engineered safety features. The evaluation also identified potential scenarios and radiological consequences. Risks were calculated in terms of 50-year population dose commitment per year (man-rem/year) to the onsite and offsite population within an 80 Km radius of RBOF and RRF, and to an individual at the plant boundary. The total 50-year onsite and offsite population radiological risks of operating the RBOF and RRF were estimated to be 1.0 man-rem/year. These risks are significantly less than the population dose of 54,000 man/rem/yr for natural background radiation in a 50-mile radius. The 50-year maximum offsite individual risk from operating the facility was estimated to be 2.1 {times} 10{sup 5} rem/yr. These risks are significantly lower than 93 mrem/yr an individual is expected to receive from natural background radiation in this area. The analysis shows. that the RBOF and RRF can be operated without undue risk to onsite personnel or to the general public.

  6. Analysis of plant gums and saccharide materials in paint samples: comparison of GC-MS analytical procedures and databases

    Science.gov (United States)

    2012-01-01

    Background Saccharide materials have been used for centuries as binding media, to paint, write and illuminate manuscripts and to apply metallic leaf decorations. Although the technical literature often reports on the use of plant gums as binders, actually several other saccharide materials can be encountered in paint samples, not only as major binders, but also as additives. In the literature, there are a variety of analytical procedures that utilize GC-MS to characterize saccharide materials in paint samples, however the chromatographic profiles are often extremely different and it is impossible to compare them and reliably identify the paint binder. Results This paper presents a comparison between two different analytical procedures based on GC-MS for the analysis of saccharide materials in works-of-art. The research presented here evaluates the influence of the analytical procedure used, and how it impacts the sugar profiles obtained from the analysis of paint samples that contain saccharide materials. The procedures have been developed, optimised and systematically used to characterise plant gums at the Getty Conservation Institute in Los Angeles, USA (GCI) and the Department of Chemistry and Industrial Chemistry of the University of Pisa, Italy (DCCI). The main steps of the analytical procedures and their optimisation are discussed. Conclusions The results presented highlight that the two methods give comparable sugar profiles, whether the samples analysed are simple raw materials, pigmented and unpigmented paint replicas, or paint samples collected from hundreds of centuries old polychrome art objects. A common database of sugar profiles of reference materials commonly found in paint samples was thus compiled. The database presents data also from those materials that only contain a minor saccharide fraction. This database highlights how many sources of saccharides can be found in a paint sample, representing an important step forward in the problem of

  7. Analysis of plant gums and saccharide materials in paint samples: comparison of GC-MS analytical procedures and databases

    Directory of Open Access Journals (Sweden)

    Lluveras-Tenorio Anna

    2012-10-01

    Full Text Available Abstract Background Saccharide materials have been used for centuries as binding media, to paint, write and illuminate manuscripts and to apply metallic leaf decorations. Although the technical literature often reports on the use of plant gums as binders, actually several other saccharide materials can be encountered in paint samples, not only as major binders, but also as additives. In the literature, there are a variety of analytical procedures that utilize GC-MS to characterize saccharide materials in paint samples, however the chromatographic profiles are often extremely different and it is impossible to compare them and reliably identify the paint binder. Results This paper presents a comparison between two different analytical procedures based on GC-MS for the analysis of saccharide materials in works-of-art. The research presented here evaluates the influence of the analytical procedure used, and how it impacts the sugar profiles obtained from the analysis of paint samples that contain saccharide materials. The procedures have been developed, optimised and systematically used to characterise plant gums at the Getty Conservation Institute in Los Angeles, USA (GCI and the Department of Chemistry and Industrial Chemistry of the University of Pisa, Italy (DCCI. The main steps of the analytical procedures and their optimisation are discussed. Conclusions The results presented highlight that the two methods give comparable sugar profiles, whether the samples analysed are simple raw materials, pigmented and unpigmented paint replicas, or paint samples collected from hundreds of centuries old polychrome art objects. A common database of sugar profiles of reference materials commonly found in paint samples was thus compiled. The database presents data also from those materials that only contain a minor saccharide fraction. This database highlights how many sources of saccharides can be found in a paint sample, representing an important step

  8. JSSG - SPACED RECEIVER MEASUREMENTS.

    Science.gov (United States)

    The height of ionospheric irregularities was measured by several laboratories belonging to the Joint Satellite Studies Group, using spaced receiver techniques. The method of analysis and results obtained are presented. (Author)

  9. Frequency of worsening liver function in severe dengue hepatitis patients receiving paracetamol: A retrospective analysis of hospital data

    International Nuclear Information System (INIS)

    Syed, A.A.; Aslam, F.; Hakeem, H.; Siddiqui, F.; Nasir, N.

    2017-01-01

    To determine the frequency of worsening liver function among hospital in-patients with severe dengue hepatitis receiving paracetamol. Methods: This retrospective study was conducted at the Department of Medicine, Aga Khan University Hospital, Karachi, and comprised records of dengue patients with severe hepatitis who received paracetamol for control of fever between June 2007 and December 2014. Alanine aminotransferase at baseline and following paracetamol administration was noted, as well as dosage and duration of paracetamol, along with participants' demographic details. Frequency of patients who developed worsening or improvement of alanine aminotransferase was also noted. SPSS 19 was used for data analysis. Results: Of the 113 subjects, 73(64.6%) were male and 40(35.4%) were female. Overall improvement was observed in subsequent alanine aminotransferase levels (491 units per litre, IQR 356.5 TO 775 vs 151 units per litre, IQR 49.5 to 299.5). Most commonly prescribed dose of paracetamol was 2g (IQR 1 to 5 grams), which was taken for a median duration of 1 day (IQR 1 to 3 days). Moreover, 100(88.5 %) patients showed improvement in alanine aminotransferase. Only 13(11.5 %) patients developed worsening of alanine aminotransferase. Of those with worsening liver function, 8(61.5 %) were discharged home with no clinical deterioration and 5(38.5 %) deaths were observed. However, causes of deaths were unrelated to liver dysfunction. Conclusion: The frequency of worsening liver function following paracetamol administration in patients with severe dengue hepatitis was relatively low. (author)

  10. Process Analytical Chemistry

    OpenAIRE

    Trevisan, Marcello G.; Poppi, Ronei J.

    2006-01-01

    Process Analytical Chemistry (PAC) is an important and growing area in analytical chemistry, that has received little attention in academic centers devoted to the gathering of knowledge and to optimization of chemical processes. PAC is an area devoted to optimization and knowledge acquisition of chemical processes, to reducing costs and wastes and to making an important contribution to sustainable development. The main aim of this review is to present to the Brazilian community the developmen...

  11. Books Received

    Indian Academy of Sciences (India)

    Digital libraries, Dynamic Storehouse of Digitised Information. N M Maiwad, T B Rajashekar, I K. Ravichandra Roo and N V. Satyanarayan. New Age International, 1996, Rs.475. Optimization Methods in Operations. Research and Systems Analysis. K V Mittal and C Mohan. 3rd Edn., New Age International. 1996. Rs.13S.

  12. I Received

    Indian Academy of Sciences (India)

    Optimization Methods in. Operations Research and. Systems Analysis, 3rd Edn. K V Mittal and C Mohan. New Age Intern<;1tional. 1996, Rs.135. The Arrow of Time. Peter Coveney and Roger. Highfield. Flamingo, an Imprint of Harper Col. 1991, Rs.252. Safety Evaluation of Environmental. Chemicals. T S S Dikshith.

  13. Analytical evaluation of the epoc® point-of-care blood analysis system in cardiopulmonary bypass patients.

    Science.gov (United States)

    Chen, Jianing; Gorman, Monique; O'Reilly, Bill; Chen, Yu

    2016-06-01

    The aim of this study was to evaluate the analytical performance of the new epoc® point-of-care blood analysis system in cardiopulmonary bypass patients. The precision study was conducted on 3 epoc® blood analysis systems using 5 levels of quality control materials twice per day for 5days. The blood specimen was collected in blood gas syringes from 40 cardiac perfusion patients for the comparison study on epoc® (all 3meters), Instrumentation Laboratory GEM4000, Abbott iSTAT, Nova CCX, and Roche Accu-Chek Inform II and Performa glucose meters. The epoc® blood analysis systems demonstrated clinically acceptable precision for all analytes (from 0.07%, 0.07%, and 0.13% for pH7.6, 7.4, and 7.0 levels; to 3.87%, 3.74%, and 7.56% for pO2 197, 103, and 56mmHg levels). Comparison studies yielded a correlation coefficient R from 0.9201 (sodium) to 0.9969 (pO2) with the GEM4000; from 0.9071 (sodium) to 0.9965 (potassium) with the iSTAT; from 0.8793 (sodium) to 0.9957 (pO2) with the CCX, and 0.9850 and 0.9904 with Roche Inform II and Performa meters respectively. Average biases for all analytes were within the total allowable error limits. The epoc® blood analysis system is acceptable for point-of-care testing in the cardiovascular surgery setting. Copyright © 2016 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

  14. Image analysis for a microfluidic paper-based analytical device using the CIE L*a*b* color system.

    Science.gov (United States)

    Komatsu, Takeshi; Mohammadi, Saeed; Busa, Lori Shayne Alamo; Maeki, Masatoshi; Ishida, Akihiko; Tani, Hirofumi; Tokeshi, Manabu

    2016-11-28

    The combination of a microfluidic paper-based analytical device (μPAD) and digital image analysis is widely used for quantitative analysis with μPADs because of its easy and simple operation. Herein, we have demonstrated a quantitative analysis based on multiple color changes on a μPAD. The CIE L*a*b* color system was employed to analyse the digital images obtained with the μPAD. We made pH measurements using a universal pH-indicator showing multiple color changes for various pH values of aqueous test solutions. The detectable pH range of this method was wider than the typical grayscale-based image analysis, and we succeeded in the measurements for a wide pH range of 2-9.

  15. The application of isogeometric analysis to the neutron diffusion equation for a pincell problem with an analytic benchmark

    International Nuclear Information System (INIS)

    Hall, S.K.; Eaton, M.D.; Williams, M.M.R.

    2012-01-01

    Highlights: ► Isogeometric analysis used to obtain solutions to the neutron diffusion equation. ► Exact geometry captured for a circular fuel pin within a square moderator. ► Comparisons are made between the finite element method and isogeometric analysis. ► Error and observed order of convergence found using an analytic solution. -- Abstract: In this paper the neutron diffusion equation is solved using Isogeometric Analysis (IGA), which is an attempt to generalise Finite Element Analysis (FEA) to include exact geometries. In contrast to FEA, the basis functions are rational functions instead of polynomials. These rational functions, called non-uniform rational B-splines, are used to capture both the geometry and approximate the solution. The method of manufactured solutions is used to verify a MatLab implementation of IGA, which is then applied to a pincell problem. This is a circular uranium fuel pin within a square block of graphite moderator. A new method is used to compute an analytic solution to a simplified version of this problem, and is then used to observe the order of convergence of the numerical scheme. Comparisons are made against quadratic finite elements for the pincell problem, and it is found that the disadvantage factor computed using IGA is less accurate. This is due to a cancellation of errors in the FEA solution. A modified pincell problem with vacuum boundary conditions is then considered. IGA is shown to outperform FEA in this situation.

  16. Analytical performance of benchtop total reflection X-ray fluorescence instrumentation for multielemental analysis of wine samples

    Science.gov (United States)

    Dalipi, Rogerta; Marguí, Eva; Borgese, Laura; Bilo, Fabjola; Depero, Laura E.

    2016-06-01

    Recent technological improvements have led to a widespread adoption of benchtop total reflection X-ray fluorescence systems (TXRF) for analysis of liquid samples. However, benchtop TXRF systems usually present limited sensitivity compared with high-scale instrumentation which can restrict its application in some fields. The aim of the present work was to evaluate and compare the analytical capabilities of two TXRF systems, equipped with low power Mo and W target X-ray tubes, for multielemental analysis of wine samples. Using the Mo-TXRF system, the detection limits for most elements were one order of magnitude lower than those attained using the W-TXRF system. For the detection of high Z elements like Cd and Ag, however, W-TXRF remains a very good option due to the possibility of K-Lines detection. Accuracy and precision of the obtained results have been evaluated analyzing spiked real wine samples and comparing the TXRF results with those obtained by inductively coupled plasma emission spectroscopy (ICP-OES). In general, good agreement was obtained between ICP-OES and TXRF results for the analysis of both red and white wine samples except for light elements (i.e., K) which TXRF concentrations were underestimated. However, a further achievement of analytical quality of TXRF results can be achieved if wine analysis is performed after dilution of the sample with de-ionized water.

  17. Analytical model for Transient Current Technique (TCT) signal prediction and analysis for thin interface characterization

    Science.gov (United States)

    Bronuzzi, J.; Mapelli, A.; Sallese, J. M.

    2016-12-01

    A silicon wafer bonding technique has been recently proposed for the fabrication of monolithic silicon radiation detectors. This new process would enable direct bonding of a read-out electronic chip wafer on a highly resistive silicon substrate wafer. Therefore, monolithic silicon detectors could be fabricated in this way which would allow the free choice of electronic chips and high resistive silicon bulk, even from different providers. Moreover, a monolithic detector with a high resistive bulk would also be available. Electrical properties of the bonded interface are then critical for this application. Indeed, mobile charges generated by radiation inside the bonded bulk are expected to transit through the interface to be collected by the read-out electronics. In order to characterize this interface, the concept of Transient Current Technique (TCT) has been explored by means of numerical simulations combined with a physics based analytical model. In this work, the analytical model giving insight into the physics behind the TCT dependence upon interface traps is validated using both TCAD simulations and experimental measurements.

  18. Evaluation of FTIR-based analytical methods for the analysis of simulated wastes

    International Nuclear Information System (INIS)

    Rebagay, T.V.; Cash, R.J.; Dodd, D.A.; Lockrem, L.L.; Meacham, J.E.; Winkelman, W.D.

    1994-01-01

    Three FTIR-based analytical methods that have potential to characterize simulated waste tank materials have been evaluated. These include: (1) fiber optics, (2) modular transfer optic using light guides equipped with non-contact sampling peripherals, and (3) photoacoustic spectroscopy. Pertinent instrumentation and experimental procedures for each method are described. The results show that the near-infrared (NIR) region of the infrared spectrum is the region of choice for the measurement of moisture in waste simulants. Differentiation of the NIR spectrum, as a preprocessing steps, will improve the analytical result. Preliminary data indicate that prominent combination bands of water and the first overtone band of the ferrocyanide stretching vibration may be utilized to measure water and ferrocyanide species simultaneously. Both near-infrared and mid-infrared spectra must be collected, however, to measure ferrocyanide species unambiguously and accurately. For ease of sample handling and the potential for field or waste tank deployment, the FTIR-Fiber Optic method is preferred over the other two methods. Modular transfer optic using light guides and photoacoustic spectroscopy may be used as backup systems and for the validation of the fiber optic data

  19. Experimental and analytical analysis of polarization and water transport behaviors of hydrogen alkaline membrane fuel cell

    Science.gov (United States)

    Huo, Sen; Zhou, Jiaxun; Wang, Tianyou; Chen, Rui; Jiao, Kui

    2018-04-01

    Experimental test and analytical modeling are conducted to investigate the operating behavior of an alkaline electrolyte membrane (AEM) fuel cell fed by H2/air (or O2) and explore the effect of various operating pressures on the water transfer mechanism. According to the experimental test, the cell performance is greatly improved through increasing the operating pressure gradient from anode to cathode which leads to significant liquid water permeation through the membrane. The high frequency resistance of the A901 alkaline membrane is observed to be relatively stable as the operating pressure varies based on the electrochemical impedance spectroscopy (EIS) method. Correspondingly, based on the modeling prediction, the averaged water content in the membrane electrode assembly (MEA) does not change too much which leads to the weak variation of membrane ohmic resistance. This reveals that the performance enhancement should give the credit to better electro-chemical reaction kinetics for both the anode and cathode, also prone by the EIS results. The reversion of water back diffusion direction across the membrane is also observed through analytical solution.

  20. Analysis of low molecular weight metabolites in tea using mass spectrometry-based analytical methods.

    Science.gov (United States)

    Fraser, Karl; Harrison, Scott J; Lane, Geoff A; Otter, Don E; Hemar, Yacine; Quek, Siew-Young; Rasmussen, Susanne

    2014-01-01

    Tea is the second most consumed beverage in the world after water and there are numerous reported health benefits as a result of consuming tea, such as reducing the risk of cardiovascular disease and many types of cancer. Thus, there is much interest in the chemical composition of teas, for example; defining components responsible for contributing to reported health benefits; defining quality characteristics such as product flavor; and monitoring for pesticide residues to comply with food safety import/export requirements. Covered in this review are some of the latest developments in mass spectrometry-based analytical techniques for measuring and characterizing low molecular weight components of tea, in particular primary and secondary metabolites. The methodology; more specifically the chromatography and detection mechanisms used in both targeted and non-targeted studies, and their main advantages and disadvantages are discussed. Finally, we comment on the latest techniques that are likely to have significant benefit to analysts in the future, not merely in the area of tea research, but in the analytical chemistry of low molecular weight compounds in general.

  1. A novel high-performance self-powered ultraviolet photodetector: Concept, analytical modeling and analysis

    Science.gov (United States)

    Ferhati, H.; Djeffal, F.

    2017-12-01

    In this paper, a new MSM-UV-photodetector (PD) based on dual wide band-gap material (DM) engineering aspect is proposed to achieve high-performance self-powered device. Comprehensive analytical models for the proposed sensor photocurrent and the device properties are developed incorporating the impact of DM aspect on the device photoelectrical behavior. The obtained results are validated with the numerical data using commercial TCAD software. Our investigation demonstrates that the adopted design amendment modulates the electric field in the device, which provides the possibility to drive appropriate photo-generated carriers without an external applied voltage. This phenomenon suggests achieving the dual role of effective carriers' separation and an efficient reduce of the dark current. Moreover, a new hybrid approach based on analytical modeling and Particle Swarm Optimization (PSO) is proposed to achieve improved photoelectric behavior at zero bias that can ensure favorable self-powered MSM-based UV-PD. It is found that the proposed design methodology has succeeded in identifying the optimized design that offers a self-powered device with high-responsivity (98 mA/W) and superior ION/IOFF ratio (480 dB). These results make the optimized MSM-UV-DM-PD suitable for providing low cost self-powered devices for high-performance optical communication and monitoring applications.

  2. Unveiling the Properties of Metagratings via a Detailed Analytical Model for Synthesis and Analysis

    Science.gov (United States)

    Epstein, Ariel; Rabinovich, Oshri

    2017-11-01

    We present detailed analytical modeling and in-depth investigation of wide-angle reflect-mode metagrating beam splitters. These recently introduced ultrathin devices are capable of implementing intricate diffraction engineering functionalities with only a single meta-atom per macroperiod, making them considerably simpler to synthesize than conventional metasurfaces. We extend recent work and focus on electrically polarizable metagratings, comprised of loaded conducting wires in front of a perfect electric conductor, excited by transverse-electric polarized fields, which are more practical for planar fabrication. The derivation further relates the metagrating performance parameters to the individual meta-atom load, facilitating an efficient semianalytical synthesis scheme to determine the required conductor geometry for achieving optimal beam splitting. Subsequently, we utilize the model to analyze the effects of realistic conductor losses, reactance deviations, and frequency shifts on the device performance, and reveal that metagratings feature preferable working points, in which the sensitivity to these nonidealities is rather low. The analytical relations shed light on the physical origin of this phenomenon, associating it with fundamental interference processes taking place in the device. These results, verified via full-wave simulations of realistic physical structures, yield a set of efficient engineering tools, as well as profound physical intuition, for devising future metagrating devices, with immense potential for microwave, terahertz, and optical beam-manipulation applications.

  3. Performances of analytical methods for freshwater analysis assessed through intercomparison exercises. II. Major ions.

    Directory of Open Access Journals (Sweden)

    Herbert MUNTAU

    1999-02-01

    Full Text Available From 1991 to 1997, nine intercomparison exercises on rainwater and freshwater samples were held in the framework of an activity connecting laboratories participating in different projects (Environmental studies in the Mediterranean basin, Italian network for the study of wet deposition, Acidification of mountain lakes, Limnological studies of Lake Léman, Monitoring of atmospheric deposition in forests. The number of participants increased from 72 in 1991 to 177 in 1997. Among the measured variables (pH, conductivity, alkalinity, major ions and nutrients, Ca, Mg, Na, K, ammonium, sulphate, chloride and nitrate are considered in this paper. The methods commonly used by the laboratories involved in the exercises are compared for precision, and an estimate of the performance of each method at different concentrations is made. The results show that some of the participating laboratories use analytical methods which are not reliable for the concentration values occurring in freshwater and/or in rainwater. However, outliers are also produced by laboratories using well-performing methods, indicating the importance of introducing analytical control procedures.

  4. The crust and mantle beneath the Siberian provinces: a preliminary model based on new receiver function analysis

    Science.gov (United States)

    Youssof, M.; Artemieva, I.; Thybo, H.; Frassetto, A.

    2012-04-01

    The new receiver function (RF) study complements the existing seismic data on the crustal and upper mantle structure at the margins of the Siberian craton and the West Siberian Basin. So far, RF studies of Siberia have been largely restricted to the Baikal rift zone (Gao et al., 2004; Liu and Gao, 2006; Anan'in et al., 2009). However, available seismic data allow to apply the RF approach to other tectonic structures of the region. We calculate the RF using the LQT method (Vinnik, 1977; Kind et al. 1995) in the version by Yuan et al. (1997). This method involves rotating the earth-oriented seismograms into ray coordinates. This decomposes the wavefield into P-SV-SH components. Converted phases are isolated by iterative, time-domain spiking deconvolution (Gurrola et al., 1995; Liggoría and Ammon, 1999) with prewhitening to stabilize the filtering. Ps phases were enhanced by stacking the deconvolved signals using the appropriate moveout corrections which account for the dependence of Ps arrivals on P wave slowness. The results of RF analysis of the crustal and mantle structure are interpreted in terms of tectonic and geodynamic evolution of different provinces of Siberia that range from the Cenozoic Baikal rift, to the Paleozoic orogenic belts of the Altaides and Uralides, the Paleozoic West Siberian basin and the Siberian trap basalt province, and the Precambrian Siberian craton. We further compare our results with seismic models for similar geodynamic settings worldwide.

  5. Study on diagnosis criteria of fire-heat syndrome based on receiver operating characteristic curve and principal component analysis.

    Science.gov (United States)

    Liu, Si-jun; Huang, Zhao-sheng; Wu, Qing-guang; Huang, Zhang-jie; Wu, Li-rong; Yan, Wen-li; Wang, Qi; Wang, Zong-wei; Chang, David Lungpao; Yang, Zheng

    2016-04-01

    To establish the diagnostic quantitative criteria for fire-heat syndrome (FHS) of Chinese medicine (CM) based on the receiver operating characteristic (ROC) curve and principal component analysis (PCA). The symptoms and signs of FHS cases and healthy subjects from Guangzhou, Henan and Hunan of China were collected through questionnaire, and the diagnostic quantitative score tables were established for the three regions, respectively, with the method of maximum likelihood analysis. The homogeneity test was then performed on the diagnostic score tables for the three regions with ROC curve, and the diagnostic efficiency of diagnostic score tables for the three regions was compared with the prospective test and retrospective test. The method of PCA was adopted to obtain the analysis matrix for classifying the tapes of FHS. Twenty-seven elements of FHS were confirmed through Chi-square test, and the diagnostic score tables for the three regions were established with the method of maximum likelihood analysis on the basis of the collected case data. According to the ROC curve test, the areas under ROC curve of Guangzhou diagnostic score table assessment with candidates in Guangzhou, Henan and Hunan were 0.998, 0.961 and 0.956, respectively. It showed that the diagnostic efficiency of Guangzhou diagnostic score tables was the highest one. With the prospective test, the area under ROC of Guangzhou diagnostic score table was 0.949, and more than any other diagnostic score table. By PCA, FHS was classified into excess fire and deficiency fire, and then classified into syndrome of flaring up of Heart (Xin) fire, syndrome of Lung (Fei)-Stomach (Wei) excess fire, syndrome of deficiency of Liver (Gan)-yin and Kidney (Shen)-yin, and syndrome of deficiency of Lung-yin from the view of viscera. In the retrospective test, the consistency with clinicians' diagnosis was 69.4%, and in the prospective test, it was 70.1%. The Guangzhou diagnostic score table could be used as the

  6. Google analytics integrations

    CERN Document Server

    Waisberg, Daniel

    2015-01-01

    A roadmap for turning Google Analytics into a centralized marketing analysis platform With Google Analytics Integrations, expert author Daniel Waisberg shows you how to gain a more meaningful, complete view of customers that can drive growth opportunities. This in-depth guide shows not only how to use Google Analytics, but also how to turn this powerful data collection and analysis tool into a central marketing analysis platform for your company. Taking a hands-on approach, this resource explores the integration and analysis of a host of common data sources, including Google AdWords, AdSens

  7. Analysis of Pre-Analytic Factors Affecting the Success of Clinical Next-Generation Sequencing of Solid Organ Malignancies

    Directory of Open Access Journals (Sweden)

    Hui Chen

    2015-08-01

    Full Text Available Application of next-generation sequencing (NGS technology to routine clinical practice has enabled characterization of personalized cancer genomes to identify patients likely to have a response to targeted therapy. The proper selection of tumor sample for downstream NGS based mutational analysis is critical to generate accurate results and to guide therapeutic intervention. However, multiple pre-analytic factors come into play in determining the success of NGS testing. In this review, we discuss pre-analytic requirements for AmpliSeq PCR-based sequencing using Ion Torrent Personal Genome Machine (PGM (Life Technologies, a NGS sequencing platform that is often used by clinical laboratories for sequencing solid tumors because of its low input DNA requirement from formalin fixed and paraffin embedded tissue. The success of NGS mutational analysis is affected not only by the input DNA quantity but also by several other factors, including the specimen type, the DNA quality, and the tumor cellularity. Here, we review tissue requirements for solid tumor NGS based mutational analysis, including procedure types, tissue types, tumor volume and fraction, decalcification, and treatment effects.

  8. Reuse of the Cloud Analytics and Collaboration Environment within Tactical Applications (TacApps): A Feasibility Analysis

    Science.gov (United States)

    2016-03-01

    TERMS Cloud analytics and collaboration environment (CACE) WebSocket Architecture Messaging Widgets Chat Software... Cloud Analytics and Collaboration Environment Background 1 Cloud Analytics and Collaboration Environment Architecture 1 Services and Components of...enhancements also exist at the data transport layer and server (ref. 2). CLOUD ANALYTICS AND COLLABORATION ENVIRONMENT ARCHITECTURE The CACE offers

  9. Crustal structure of the rifted volcanic margins and uplifted plateau of Western Yemen from receiver function analysis

    Science.gov (United States)

    Ahmed, Abdulhakim; Tiberi, Christel; Leroy, Sylvie; Stuart, Graham W.; Keir, Derek; Sholan, Jamal; Khanbari, Khaled; Al-Ganad, Ismael; Basuyau, Clémence

    2013-06-01

    We analyse P-wave receiver functions across the western Gulf of Aden and southern Red Sea continental margins in Western Yemen to constrain crustal thickness, internal crustal structure and the bulk seismic velocity characteristics in order to address the role of magmatism, faulting and mechanical crustal thinning during continental breakup. We analyse teleseismic data from 21 stations forming the temporary Young Conjugate Margins Laboratory (YOCMAL) network together with GFZ and Yemeni permanent stations. Analysis of computed receiver functions shows that (1) the thickness of unextended crust on the Yemen plateau is ˜35 km; (2) this thins to ˜22 km in coastal areas and reaches less than 14 km on the Red Sea coast, where presence of a high-velocity lower crust is evident. The average Vp/Vs ratio for the western Yemen Plateau is 1.79, increasing to ˜1.92 near the Red Sea coast and decreasing to 1.68 for those stations located on or near the granitic rocks. Thinning of the crust, and by inference extension, occurs over a ˜130-km-wide transition zone from the Red Sea and Gulf of Aden coasts to the edges of the Yemen plateau. Thinning of continental crust is particularly localized in a <30-km-wide zone near the coastline, spatially co-incident with addition of magmatic underplate to the lower crust, above which on the surface we observe the presence of seaward dipping reflectors (SDRs) and thickened Oligo-Miocene syn-rift basaltic flows. Our results strongly suggest the presence of high-velocity mafic intrusions in the lower crust, which are likely either synrift magmatic intrusion into continental lower crust or alternatively depleted upper mantle underplated to the base of the crust during the eruption of the SDRs. Our results also point towards a regional breakup history in which the onset of rifting was synchronous along the western Gulf of Aden and southern Red Sea volcanic margins followed by a second phase of extension along the Red Sea margin.

  10. Analysis and Design of I/Q Charge-Sharing Band-Pass-Filter for Superheterodyne Receivers

    NARCIS (Netherlands)

    Madadi, I.; Tohidian, M.; Staszewski, R.B.

    2015-01-01

    A complex quadrature charge-sharing (CS) technique is proposed to implement a discrete-time band-pass filter (BPF) with a programmable bandwidth of 20–100 MHz. The BPF is part of a cellular superheterodyne receiver and completely determines the receiver frequency selectivity. It operates at the full

  11. Priority survey between indicators and analytic hierarchy process analysis for green chemistry technology assessment.

    Science.gov (United States)

    Kim, Sungjune; Hong, Seokpyo; Ahn, Kilsoo; Gong, Sungyong

    2015-01-01

    This study presents the indicators and proxy variables for the quantitative assessment of green chemistry technologies and evaluates the relative importance of each assessment element by consulting experts from the fields of ecology, chemistry, safety, and public health. The results collected were subjected to an analytic hierarchy process to obtain the weights of the indicators and the proxy variables. These weights may prove useful in avoiding having to resort to qualitative means in absence of weights between indicators when integrating the results of quantitative assessment by indicator. This study points to the limitations of current quantitative assessment techniques for green chemistry technologies and seeks to present the future direction for quantitative assessment of green chemistry technologies.

  12. Nonlinear effects in Paul traps operated in the second stability region: analytical analysis and numerical verification.

    Science.gov (United States)

    Xiong, Caiqiao; Zhou, Xiaoyu; Zhang, Ning; Zhan, Lingpeng; Chen, Suming; Nie, Zongxiu

    2014-11-01

    Paul trap working in the second stability region has long been recognized as a possible approach for achieving high-resolution mass spectrometry (MS), which however is still far away from the experimental implementations because of the narrow working area and inefficient ion trapping. Full understanding of the ion motional behavior is helpful for solving the problem. In this article, the ion motion in a superimposed octopole field, which was characterized by the nonlinear Mathieu equation, was solved analytically using Poincare-Lighthill-Kuo (PLK) method. This method equivalently described the nonlinear disturbance by an effective quadrupole field with perturbed Mathieu parameters, a(u) and q(u), which would bring huge convenience in the studies of nonlinear ion dynamics and was, therefore, used for rapid evaluation of the nonlinear effects of ion motion. Fourth-order Runge-Kutta method (4th R-K) indicated the error of PLK for characterizing the frequency shift of ion motion was within 15%.

  13. Comparison of Heat Insulations for Cryogenic Tankers Using Analytical and Numerical Analysis

    Directory of Open Access Journals (Sweden)

    Ramón Miralbés Buil

    2013-01-01

    Full Text Available This paper presented a methodology for the design of heat insulations used in cryogenic tankers. This insulation usually comprises a combination of vacuum and perlite or vacuum and superinsulation. Concretely, it is a methodology to obtain the temperatures, heat fluxes, and so forth. Using analytical tools has been established, which is based on the equivalence with an electric circuit, and on numerical tools using finite elements. Results obtained with both methods are then compared. In addition, the influence of the outer finish of the external part, due to the effect of the solar radiation, is analyzed too, and the equations to determine the maximum time available to transport the cryogenic liquid have been established. All these aspects are applied to a specific cryogenic commercial vehicle.

  14. Intracavity optogalvanic spectroscopy. An analytical technique for 14C analysis with subattomole sensitivity.

    Science.gov (United States)

    Murnick, Daniel E; Dogru, Ozgur; Ilkmen, Erhan

    2008-07-01

    We show a new ultrasensitive laser-based analytical technique, intracavity optogalvanic spectroscopy, allowing extremely high sensitivity for detection of (14)C-labeled carbon dioxide. Capable of replacing large accelerator mass spectrometers, the technique quantifies attomoles of (14)C in submicrogram samples. Based on the specificity of narrow laser resonances coupled with the sensitivity provided by standing waves in an optical cavity and detection via impedance variations, limits of detection near 10(-15) (14)C/(12)C ratios are obtained. Using a 15-W (14)CO2 laser, a linear calibration with samples from 10(-15) to >1.5 x 10(-12) in (14)C/(12)C ratios, as determined by accelerator mass spectrometry, is demonstrated. Possible applications include microdosing studies in drug development, individualized subtherapeutic tests of drug metabolism, carbon dating and real time monitoring of atmospheric radiocarbon. The method can also be applied to detection of other trace entities.

  15. Biomarker Analysis of Stored Blood Products: Emphasis on Pre-Analytical Issues

    Directory of Open Access Journals (Sweden)

    Niels Lion

    2010-11-01

    Full Text Available Millions of blood products are transfused every year; many lives are thus directly concerned by transfusion. The three main labile blood products used in transfusion are erythrocyte concentrates, platelet concentrates and fresh frozen plasma. Each of these products has to be stored according to its particular components. However, during storage, modifications or degradation of those components may occur, and are known as storage lesions. Thus, biomarker discovery of in vivo blood aging as well as in vitro labile blood products storage lesions is of high interest for the transfusion medicine community. Pre-analytical issues are of major importance in analyzing the various blood products during storage conditions as well as according to various protocols that are currently used in blood banks for their preparations. This paper will review key elements that have to be taken into account in the context of proteomic-based biomarker discovery applied to blood banking.

  16. Painleve analysis and new analytical solutions for compound KdV-Burgers equation with variable coefficients

    International Nuclear Information System (INIS)

    Abourabia, A.M.; Hassan, K.M.; Selima, E.S.

    2010-01-01

    We consider the solutions of the compound Korteweg-de Vries (KdV)-Burgers equation with variable coefficients (vccKdV-B) that describe the propagation of undulant bores in shallow water with certain dissipative effects. The Weiss-Tabor-Carnevale (WTC)-Kruskal algorithm is applied to study the integrability of the vccKdV-B equation. We found that the vccKdV-B equation is not Painleve integrable unless the variable coefficients satisfy certain constraints. We used the outcome of the truncated Painleve expansion to construct the Backlund transformation, and three families of new analytical solutions for the vccKdV-B equation are obtained. The dispersion relation and its characteristics are illustrated. The stability for the vccKdV-B equation is analyzed by using the phase portrait method. (author)

  17. Painleve analysis and new analytical solutions for compound KdV-Burgers equation with variable coefficients

    Energy Technology Data Exchange (ETDEWEB)

    Abourabia, A.M.; Hassan, K.M.; Selima, E.S., E-mail: am_abourabia@yahoo.com [Menoufiya Univ., Faculty of Science, Dept. of Mathematics, Shebin El-koom (Egypt)

    2010-03-15

    We consider the solutions of the compound Korteweg-de Vries (KdV)-Burgers equation with variable coefficients (vccKdV-B) that describe the propagation of undulant bores in shallow water with certain dissipative effects. The Weiss-Tabor-Carnevale (WTC)-Kruskal algorithm is applied to study the integrability of the vccKdV-B equation. We found that the vccKdV-B equation is not Painleve integrable unless the variable coefficients satisfy certain constraints. We used the outcome of the truncated Painleve expansion to construct the Backlund transformation, and three families of new analytical solutions for the vccKdV-B equation are obtained. The dispersion relation and its characteristics are illustrated. The stability for the vccKdV-B equation is analyzed by using the phase portrait method. (author)

  18. Publication bias in studies of an applied behavior-analytic intervention: an initial analysis.

    Science.gov (United States)

    Sham, Elyssa; Smith, Tristram

    2014-01-01

    Publication bias arises when studies with favorable results are more likely to be reported than are studies with null findings. If this bias occurs in studies with single-subject experimental designs(SSEDs) on applied behavior-analytic (ABA) interventions, it could lead to exaggerated estimates of intervention effects. Therefore, we conducted an initial test of bias by comparing effect sizes, measured by percentage of nonoverlapping data (PND), in published SSED studies (n=21) and unpublished dissertations (n=10) on 1 well-established intervention for children with autism, pivotal response treatment (PRT). Although published and unpublished studies had similar methodologies, the mean PND in published studies was 22% higher than in unpublished studies, 95% confidence interval (4%, 38%). Even when unpublished studies are included, PRT appeared to be effective (PNDM=62%). Nevertheless, the disparity between published and unpublished studies suggests a need for further assessment of publication bias in the ABA literature.

  19. Biomarker Analysis of Stored Blood Products: Emphasis on Pre-Analytical Issues

    Science.gov (United States)

    Delobel, Julien; Rubin, Olivier; Prudent, Michel; Crettaz, David; Tissot, Jean-Daniel; Lion, Niels

    2010-01-01

    Millions of blood products are transfused every year; many lives are thus directly concerned by transfusion. The three main labile blood products used in transfusion are erythrocyte concentrates, platelet concentrates and fresh frozen plasma. Each of these products has to be stored according to its particular components. However, during storage, modifications or degradation of those components may occur, and are known as storage lesions. Thus, biomarker discovery of in vivo blood aging as well as in vitro labile blood products storage lesions is of high interest for the transfusion medicine community. Pre-analytical issues are of major importance in analyzing the various blood products during storage conditions as well as according to various protocols that are currently used in blood banks for their preparations. This paper will review key elements that have to be taken into account in the context of proteomic-based biomarker discovery applied to blood banking. PMID:21151459

  20. Analytical and experimental analysis of a low-pressure heat exchanger suitable for passive ventilation

    DEFF Research Database (Denmark)

    Hviid, Christian Anker; Svendsen, Svend

    2011-01-01

    that is commonly used in water-based floor-heating systems. The pressure loss and temperature exchange efficiency was measured. For a design airflow rate of 560L/s, the pressure loss was 0.37Pa and the efficiency was 75.6%. The experimental results agree well with the literature or numerical fluid calculations......AbstractA core element in sustainable ventilation systems is the heat recovery system. Conventional heat recovery systems have a high pressure drop that acts as blockage to naturally driven airflow. The heat recovery system we propose here consists of two separated air-to-liquid heat exchangers...... interconnected by a liquid loop powered by a pump ideal as a component in a heat recovery system for passive ventilation systems. This paper describes the analytical framework and the experimental development of one exchanger in the liquid-loop. The exchanger was constructed from the 8mm plastic tubing...

  1. Analytical characterization of human milk oligosaccharides - potential applications in pharmaceutical analysis.

    Science.gov (United States)

    Grabarics, Márkó; Csernák, Orsolya; Balogh, Réka; Béni, Szabolcs

    2017-11-30

    Human breast milk is the gold standard for infant feeding and the best possible nourishment a new-born could have. Breastfeeding is the natural way to provide optimal nutritional, immunological and emotional nurturing for the healthy growth and development of infants. Human milk is a complex and dynamic biofluid comprised of many hundreds to thousands of distinct bioactive structures, among which one of the most abundant substances are the non-conjugated complex carbohydrates referred to as human milk oligosaccharides (HMOs). Due to their structural diversity and abundance, HMOs possess many beneficial biological functions. In order to understand human milk composition and HMO functions, state-of-the-art glycomic methods are inevitable. The industrial, large scale chemoenzymatic production of the most abundant HMOs became a reality in the last years and it evokes the need for straightforward and genuine analytical procedures to monitor the synthetic process and the quality of the products. It is obvious, that HMOs represent the next breakthrough in infant nutrition, as the addition of HMOs (such as 2'-fucosyllactose or lacto-N-neotetraose) to infant- and follow-on formulas, processed cereal-based food and baby foods for infants and young children etc. will revolutionize this field. This review highlights the potential applications of HMOs in the (bio)pharmaceutical industry, also summarizes the analytical methods available for the characterization of HMOs. An overview of the structure and function of HMOs along with their determination methods in complex matrices are provided. Various separation methods including liquid- and gas chromatography and capillary electrophoresis for the characterization and novel approaches for the quantitation of HMOs are discussed. Copyright © 2017 Elsevier B.V. All rights reserved.

  2. Prevalence of antisocial personality disorder among Chinese individuals receiving treatment for heroin dependence: a meta-analysis

    Science.gov (United States)

    ZHONG, Baoliang; XIANG, Yutao; CAO, Xiaolan; LI, Yan; ZHU, Junhong; CHIU, Helen F. K.

    2014-01-01

    Background Studies from Western countries consistently report very high rates of comorbid Antisocial Personality Disorder (ASPD) among individuals with heroin addiction, but the reported proportion of Chinese individuals with heroin addiction who have co-morbid ASPD varies widely, possibly because Chinese clinicians do not consider personality issues when treating substance abuse problems. Aim Conduct a meta-analysis of studies that assessed the proportion of Chinese individuals with heroin dependence who have comorbid ASPD. Methods We searched for relevant studies in both Chinese databases (China National Knowledge Infrastructure, Wanfang Data Knowledge Service Platform, Taiwan Electronic Periodical Services) and western databases (PubMed, EMBASE, and PsycInfo). Two authors independently retrieved the literature, identified studies that met pre-defined inclusion and exclusion criteria, assessed the quality of included studies, and extracted the data used in the analysis. Statistical analysis was performed using StatsDirect 3.0 and R software. Results The search yielded 15 eligible studies with a total of 3692 individuals with heroin dependence. Only 2 of the studies were rated as high-quality studies. All studies were conducted in rehabilitation centers or hospitals. The pooled lifetime prevalence of ASPD in these subjects was 30% (95%CI: 23%-38%), but the heterogeneity of results across studies was great (I2 =95%, p<0.001). Men had a higher prevalence than women (44% vs. 21%), and injection heroin users had higher prevalence than those who smoked heroin (44% vs. 27%). Studies that were methodologically stronger had higher reported prevalence of ASPD among heroin dependent individuals. Conclusions There are substantial methodological problems in the available literature about ASPD in Chinese individuals receiving treatment for heroin dependence, but we estimate that about one-third of them meet criteria for ASPD. Further work is needed to increase clinicians

  3. Performance Analysis of a Six-Port Receiver in a WCDMA Communication System including a Multipath Fading Channel

    Directory of Open Access Journals (Sweden)

    A. O. Olopade

    2014-01-01

    Full Text Available Third generation communication systems require receivers with wide bandwidth of operation to support high transmission rates and are also reconfigurable to support various communication standards with different frequency bands. An ideal software defined radio (SDR will be the absolute answer to this requirement but it is not achievable with the current level of technology. This paper proposes the use of a six-port receiver (SPR front-end (FE in a WCDMA communication system. A WCDMA end-to-end physical layer MATLAB demo which includes a multipath channel distortion block is used to determine the viability of the six-port based receiver. The WCDMA signal after passing through a multipath channel is received using a constructed SPR FE. The baseband signal is then calibrated and corrected in MATLAB. The six-port receiver performance is measured in terms of bit error rate (BER. The signal-to-noise ratio (SNR of the transmitted IQ data is varied and the BER profile of the communication system is plotted. The effect of the multipath fading on the receiver performance and the accuracy of the calibration algorithm are obtained by comparing two different measured BER curves for different calibration techniques to the simulated BER curve of an ideal receiver.

  4. Investigating the health profile of patients with end-stage renal failure receiving peritoneal dialysis: a cluster analysis.

    Science.gov (United States)

    Chan, M F; Wong, Frances K Y; Chow, Susan K Y

    2010-03-01

    To determine whether the patients with end stage renal failure can be differentiated into several subtypes based on five main variables. There is a lack of interventional research linking to clinical outcomes among the patients with end stage renal failure in Hong Kong and with no clear evidence of differences in terms of their clinical/health outcomes and characteristics. A cross-sectional survey. Data were collected using a structured questionnaire. One hundred and fifty-three patients with end stage renal failure were recruited during 2007 at three renal centres in Hong Kong. Five main variables were employed: predisposing characteristic, enabling resources, quality of life, symptom control and self-care adherence. A cluster analysis yielded two clusters. Each cluster represented a different profile of patients with end stage renal failure. Cluster A consisted of 49.7% (n = 76) and Cluster B consisted of 50.3% (n = 77) of the patients. Cluster A patients, more of whom were women, were older, less educated, had higher quality of life scores, a better adherence rate and more had received nursing care supports than patients in Cluster B. We have identified two groupings of patients with end stage renal failure who were experiencing unique health profile. Nursing support services may have an effect on patient health outcomes but only on a group of patients whose profile is similar to the patients in Cluster A and not for patients in Cluster B. A clear profile may help health care professional make appropriate strategies to target a specific group of patients to improve patient outcomes. The identification of risk for future health-care use could enable better targeting of interventional strategies in these groups. The results of this study might provide health care professionals with a model to design specified interventions to improve life quality for each profile group.

  5. Critical thresholds of liver function parameters for ketosis prediction in dairy cows using receiver operating characteristic (ROC) analysis.

    Science.gov (United States)

    Sun, Yuhang; Wang, Bo; Shu, Shi; Zhang, Hongyou; Xu, Chuang; Wu, Ling; Xia, Cheng

    2015-01-01

    Fatty liver syndrome and ketosis are important metabolic disorders in high-producing cows during early lactation with fatty liver usually preceding ketosis. To date, parameters for early prediction of the risk of ketosis have not been investigated in China. To determine the predictive value of some parameters on the risk of ketosis in China. In a descriptive study, 48 control and 32 ketotic Holstein Friesian cows were randomly selected from one farm with a serum β-hydroxybutyrate (BHBA) concentration of 1.20 mmol/L as cutoff point. The risk prediction thresholds for ketosis were determined by receiver operating characteristic (ROC) analysis. In line with a high BHBA concentration, blood glucose concentration was significantly lower in ketotic cows compared to control animals (2.77 ± 0.24 versus 3.34 ± 0.03 mmol/L; P = 0.02). Thresholds were more than 0.76 mmol/L for nonesterified fatty acids (NEFA, with 65% sensitivity and 92% specificity), more than 104 U/L for aspartate aminotransferase (AST, 74% and 85%, respectively), less than 140 U/L for cholinesterase (CHE, 75% and 59%, respectively), and more than 3.3 µmol/L for total bilirubin (TBIL, 58% and 83%, respectively). There were significant correlations between BHBA and glucose (R = -4.74), or CHE (R = -0.262), BHBA and NEFA (R = 0.520), or AST (R = 0.525), or TBIL (R = 0.278), or direct bilirubin (DBIL, R = 0.348). AST, CHE, TBIL and NEFA may be useful parameters for risk prediction of ketosis. This study might be of value in addressing novel directions for future research on the connection between ketosis and liver dysfunction.

  6. Hepatitis B reactivation in HBsAg-negative/HBcAb-positive patients receiving rituximab for lymphoma: a meta-analysis.

    Science.gov (United States)

    Mozessohn, L; Chan, K K W; Feld, J J; Hicks, L K

    2015-10-01

    Patients with chronic hepatitis B (HBsAg-positive) are at risk of viral reactivation if rituximab is administered without antiviral treatment, a potentially fatal complication of treatment. Patients with so-called 'resolved hepatitis B virus infection' (HBsAg-negative/cAb-positive) may also be at risk. We performed a systematic review of the English and Chinese language literature to estimate the risk of hepatitis B virus (HBV) reactivation in HBsAg-negative/cAb-positive patients receiving rituximab for lymphoma. A pooled risk estimate was calculated for HBV reactivation. The impact of HBsAb status and study design on reactivation rates was explored. Data from 578 patients in 15 studies were included. 'Clinical HBV reactivation', (ALT >3 × normal and either an increase in HBV DNA from baseline or HBsAg seroreversion), was estimated at 6.3% (I(2) = 63%, P = 0.006). Significant heterogeneity was detected. Reactivation rates were higher in prospective vs retrospective studies (14.2% vs 3.8%; OR = 4.39, 95% CI 0.83-23.28). Exploratory analyses found no effect of HBsAb status on reactivation risk (OR = 0.083; P = 0.151). Our meta-analysis confirms a measurable and potentially substantial risk of HBV reactivation in HBsAg-negative/cAb-positive patients exposed to rituximab. However, heterogeneity in the existing literature limits the generalizability of our findings. Large, prospective studies, with uniform definitions of HBV reactivation, are needed to clarify the risk of HBV reactivation in HBsAg-negative/cAb-positive patients. © 2015 John Wiley & Sons Ltd.

  7. Analytical chemistry

    Czech Academy of Sciences Publication Activity Database

    Křivánková, Ludmila

    -, č. 22 (2011), s. 718-719 ISSN 1472-3395 Institutional research plan: CEZ:AV0Z40310501 Keywords : analytical chemistry * analytical methods * nanotechnologies Subject RIV: CB - Analytical Chemistry, Separation http://edition.pagesuite-professional.co.uk/launch.aspx?referral=other&pnum=&refresh=M0j83N1cQa91&EID=82bccec1-b05f-46f9-b085-701afc238b42&skip=

  8. Analytic trigonometry

    CERN Document Server

    Bruce, William J; Maxwell, E A; Sneddon, I N

    1963-01-01

    Analytic Trigonometry details the fundamental concepts and underlying principle of analytic geometry. The title aims to address the shortcomings in the instruction of trigonometry by considering basic theories of learning and pedagogy. The text first covers the essential elements from elementary algebra, plane geometry, and analytic geometry. Next, the selection tackles the trigonometric functions of angles in general, basic identities, and solutions of equations. The text also deals with the trigonometric functions of real numbers. The fifth chapter details the inverse trigonometric functions

  9. High-resolution continuum source electrothermal atomic absorption spectrometry - An analytical and diagnostic tool for trace analysis

    International Nuclear Information System (INIS)

    Welz, Bernhard; Borges, Daniel L.G.; Lepri, Fabio G.; Vale, Maria Goreti R.; Heitmann, Uwe

    2007-01-01

    The literature about applications of high-resolution continuum source atomic absorption spectrometry (HR-CS AAS) with electrothermal atomization is reviewed. The historic development of HR-CS AAS is briefly summarized and the main advantages of this technique, mainly the 'visibility' of the spectral environment around the analytical line at high resolution and the unequaled simultaneous background correction are discussed. Simultaneous multielement CS AAS has been realized only in a very limited number of cases. The direct analysis of solid samples appears to have gained a lot from the special features of HR-CS AAS, and the examples from the literature suggest that calibration can be carried out against aqueous standards. Low-temperature losses of nickel and vanadyl porphyrins could be detected and avoided in the analysis of crude oil due to the superior background correction system. The visibility of the spectral environment around the analytical line revealed that the absorbance signal measured for phosphorus at the 213.6 nm non-resonance line without a modifier is mostly due to the PO molecule, and not to atomic phosphorus. The future possibility to apply high-resolution continuum source molecular absorption for the determination of non-metals is discussed

  10. Impact of pre-analytical factors on the proteomic analysis of formalin-fixed paraffin-embedded tissue.

    Science.gov (United States)

    Thompson, Seonaid M; Craven, Rachel A; Nirmalan, Niroshini J; Harnden, Patricia; Selby, Peter J; Banks, Rosamonde E

    2013-04-01

    Formalin-fixed paraffin-embedded (FFPE) tissue samples represent a tremendous potential resource for biomarker discovery, with large numbers of samples in hospital pathology departments and links to clinical information. However, the cross-linking of proteins and nucleic acids by formalin fixation has hampered analysis and proteomic studies have been restricted to using frozen tissue, which is more limited in availability as it needs to be collected specifically for research. This means that rare disease subtypes cannot be studied easily. Recently, improved extraction techniques have enabled analysis of FFPE tissue by a number of proteomic techniques. As with all clinical samples, pre-analytical factors are likely to impact on the results obtained, although overlooked in many studies. The aim of this review is to discuss the various pre-analytical factors, which include warm and cold ischaemic time, size of sample, fixation duration and temperature, tissue processing conditions, length of storage of archival tissue and storage conditions, and to review the studies that have considered these factors in more detail. In those areas where investigations are few or non-existent, illustrative examples of the possible importance of specific factors have been drawn from studies using frozen tissue or from immunohistochemical studies of FFPE tissue. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  11. Recursive organizer (ROR): an analytic framework for sequence-based association analysis.

    Science.gov (United States)

    Zhao, Lue Ping; Huang, Xin

    2013-07-01

    The advent of next-generation sequencing technologies affords the ability to sequence thousands of subjects cost-effectively, and is revolutionizing the landscape of genetic research. With the evolving genotyping/sequencing technologies, it is not unrealistic to expect that we will soon obtain a pair of diploidic fully phased genome sequences from each subject in the near future. Here, in light of this potential, we propose an analytic framework called, recursive organizer (ROR), which recursively groups sequence variants based upon sequence similarities and their empirical disease associations, into fewer and potentially more interpretable super sequence variants (SSV). As an illustration, we applied ROR to assess an association between HLA-DRB1 and type 1 diabetes (T1D), discovering SSVs of HLA-DRB1 with sequence data from the Wellcome Trust Case Control Consortium. Specifically, ROR reduces 36 observed unique HLA-DRB1 sequences into 8 SSVs that empirically associate with T1D, a fourfold reduction of sequence complexity. Using HLA-DRB1 data from Type 1 Diabetes Genetics Consortium as cases and data from Fred Hutchinson Cancer Research Center as controls, we are able to validate associations of these SSVs with T1D. Further, SSVs consist of nine nucleotides, and each associates with its corresponding amino acids. Detailed examination of these selected amino acids reveals their potential functional roles in protein structures and possible implication to the mechanism of T1D.

  12. Analytical and Numerical Tooth Contact Analysis (TCA of Standard and Modified Involute Profile Spur Gear

    Directory of Open Access Journals (Sweden)

    Nassear Rasheid Hmoad

    2016-03-01

    Full Text Available Among all the common mechanical transmission elements, gears still playing the most dominant role especially in the heavy duty works offering extraordinary performance under extreme conditions and that the cause behind the extensive researches concentrating on the enhancement of its durability to do its job as well as possible. Contact stress distribution within the teeth domain is considered as one of the most effective parameters characterizing gear life, performance, efficiency, and application so that it has been well sought for formal gear profiles and paid a lot of attention for moderate tooth shapes. The aim of this work is to investigate the effect of pressure angle, speed ratio, and correction factor on the maximum contact and bending stress value and principal stresses distribution for symmetric and asymmetric spur gear. The analytical investigation adopted Hertz equations to find the contact stress value, distribution, and the contact zone width while the numerical part depends on Ansys software version 15, as a FE solver with Lagrange and penalty contact algorithm. The most fruitful points to be noticed are that the increasing of pressure angle and speed ratio trends to minimize all the induced stresses for the classical gears and the altered teeth shape with larger loaded side pressure angle than the unloaded side one behave better than the symmetric teeth concerning the stress reduction.

  13. Material degradation due to moisture and temperature. Part 1: mathematical model, analysis, and analytical solutions

    Science.gov (United States)

    Xu, C.; Mudunuru, M. K.; Nakshatrala, K. B.

    2016-11-01

    The mechanical response, serviceability, and load-bearing capacity of materials and structural components can be adversely affected due to external stimuli, which include exposure to a corrosive chemical species, high temperatures, temperature fluctuations (i.e., freezing-thawing), cyclic mechanical loading, just to name a few. It is, therefore, of paramount importance in several branches of engineering—ranging from aerospace engineering, civil engineering to biomedical engineering—to have a fundamental understanding of degradation of materials, as the materials in these applications are often subjected to adverse environments. As a result of recent advancements in material science, new materials such as fiber-reinforced polymers and multi-functional materials that exhibit high ductility have been developed and widely used, for example, as infrastructural materials or in medical devices (e.g., stents). The traditional small-strain approaches of modeling these materials will not be adequate. In this paper, we study degradation of materials due to an exposure to chemical species and temperature under large strain and large deformations. In the first part of our research work, we present a consistent mathematical model with firm thermodynamic underpinning. We then obtain semi-analytical solutions of several canonical problems to illustrate the nature of the quasi-static and unsteady behaviors of degrading hyperelastic solids.

  14. Analytical expressions for chatter analysis in milling operations with one dominant mode

    Science.gov (United States)

    Iglesias, A.; Munoa, J.; Ciurana, J.; Dombovari, Z.; Stepan, G.

    2016-08-01

    In milling, an accurate prediction of chatter is still one of the most complex problems in the field. The presence of these self-excited vibrations can spoil the surface of the part and can also cause a large reduction in tool life. The stability diagrams provide a practical selection of the optimum cutting conditions determined either by time domain or frequency domain based methods. Applying these methods parametric or parameter traced representations of the linear stability limits can be achieved by solving the corresponding eigenvalue problems. In this work, new analytical formulae are proposed related to the parameter domains of both Hopf and period doubling type stability boundaries emerging in the regenerative mechanical model of time periodical milling processes. These formulae are useful to enrich and speed up the currently used numerical methods. Also, the destabilization mechanism of double period chatter is explained, creating an analogy with the chatter related to the Hopf bifurcation, considering one dominant mode and using concepts established by the Pioneers of chatter research.

  15. Transient analysis of leaky Lamb waves with a semi-analytical finite element method.

    Science.gov (United States)

    Inoue, Daisuke; Hayashi, Takahiro

    2015-09-01

    We previously formulated a semi-analytical finite element technique for Lamb waves in a plate surrounded by fluids and investigated the dispersion curves and wave structures for leaky Lamb waves. Herein, this technique is extended to the calculation of transient responses both in a plate and in fluids for dynamic loading on the plate surface. To gain fundamental insights into guided wave inspection for a water-filled pipe or tank, guided waves generated upon transient loading of a flat plate water-loaded on one side were analyzed. The results show that a quasi-Scholte mode propagating at the plate-water interface is useful for the long-range inspection of a water-loaded plate because of its non-attenuation and minimal dispersion; moreover, this mode has superior generation efficiency in the low-frequency range, while it is localized near the plate-water interface at higher frequencies. Copyright © 2015 Elsevier B.V. All rights reserved.

  16. General analytical approach for sound transmission loss analysis through a thick metamaterial plate

    International Nuclear Information System (INIS)

    Oudich, Mourad; Zhou, Xiaoming; Badreddine Assouar, M.

    2014-01-01

    We report theoretically and numerically on the sound transmission loss performance through a thick plate-type acoustic metamaterial made of spring-mass resonators attached to the surface of a homogeneous elastic plate. Two general analytical approaches based on plane wave expansion were developed to calculate both the sound transmission loss through the metamaterial plate (thick and thin) and its band structure. The first one can be applied to thick plate systems to study the sound transmission for any normal or oblique incident sound pressure. The second approach gives the metamaterial dispersion behavior to describe the vibrational motions of the plate, which helps to understand the physics behind sound radiation through air by the structure. Computed results show that high sound transmission loss up to 72 dB at 2 kHz is reached with a thick metamaterial plate while only 23 dB can be obtained for a simple homogeneous plate with the same thickness. Such plate-type acoustic metamaterial can be a very effective solution for high performance sound insulation and structural vibration shielding in the very low-frequency range

  17. Exploratory analysis regarding the domain definitions for computer based analytical models

    Science.gov (United States)

    Raicu, A.; Oanta, E.; Barhalescu, M.

    2017-08-01

    Our previous computer based studies dedicated to structural problems using analytical methods defined the composite cross section of a beam as a result of Boolean operations with so-called ‘simple’ shapes. Using generalisations, in the class of the ‘simple’ shapes were included areas bounded by curves approximated using spline functions and areas approximated as polygons. However, particular definitions lead to particular solutions. In order to ascend above the actual limitations, we conceived a general definition of the cross sections that are considered now calculus domains consisting of several subdomains. The according set of input data use complex parameterizations. This new vision allows us to naturally assign a general number of attributes to the subdomains. In this way there may be modelled new phenomena that use map-wise information, such as the metal alloys equilibrium diagrams. The hierarchy of the input data text files that use the comma-separated-value format and their structure are also presented and discussed in the paper. This new approach allows us to reuse the concepts and part of the data processing software instruments already developed. The according software to be subsequently developed will be modularised and generalised in order to be used in the upcoming projects that require rapid development of computer based models.

  18. Analysis and Reflections on the Third Learning Analytics and Knowledge Conference (LAK 2013)

    Science.gov (United States)

    Ochoa, Xavier; Suthers, Dan; Verbert, Katrien; Duval, Erik

    2014-01-01

    Analyzing a conference, especially one as young and focused as LAK, provides the opportunity to observe the structure and contributions of the scientific community around it. This work will perform a Scientometric analysis, coupled with a more in-depth manual content analysis, to extract this insight from the proceedings and program of LAK 2013.…

  19. Elasto-plastic strain analysis by a semi-analytical method

    Indian Academy of Sciences (India)

    Some indicative results have been presented for static and dynamic problems and the solution methodology developed for one-dimension has been extended to the elasto-plastic analysis of two-dimensional strain field prob- lems of a rotating disk. Keywords. Non-uniform taper bar; rotating disk; elasto-plastic strain analysis ...

  20. Predictors of Outcome in Traumatic Brain Injury: New Insight Using Receiver Operating Curve Indices and Bayesian Network Analysis.

    Directory of Open Access Journals (Sweden)

    Zsolt Zador

    Full Text Available Traumatic brain injury remains a global health problem. Understanding the relative importance of outcome predictors helps optimize our treatment strategies by informing assessment protocols, clinical decisions and trial designs. In this study we establish importance ranking for outcome predictors based on receiver operating indices to identify key predictors of outcome and create simple predictive models. We then explore the associations between key outcome predictors using Bayesian networks to gain further insight into predictor importance.We analyzed the corticosteroid randomization after significant head injury (CRASH trial database of 10008 patients and included patients for whom demographics, injury characteristics, computer tomography (CT findings and Glasgow Outcome Scale (GCS were recorded (total of 13 predictors, which would be available to clinicians within a few hours following the injury in 6945 patients. Predictions of clinical outcome (death or severe disability at 6 months were performed using logistic regression models with 5-fold cross validation. Predictive performance was measured using standardized partial area (pAUC under the receiver operating curve (ROC and we used Delong test for comparisons. Variable importance ranking was based on pAUC targeted at specificity (pAUCSP and sensitivity (pAUCSE intervals of 90-100%. Probabilistic associations were depicted using Bayesian networks.Complete AUC analysis showed very good predictive power (AUC = 0.8237, 95% CI: 0.8138-0.8336 for the complete model. Specificity focused importance ranking highlighted age, pupillary, motor responses, obliteration of basal cisterns/3rd ventricle and midline shift. Interestingly when targeting model sensitivity, the highest-ranking variables were age, severe extracranial injury, verbal response, hematoma on CT and motor response. Simplified models, which included only these key predictors, had similar performance (pAUCSP = 0.6523, 95% CI: 0

  1. Receiver Gain Modulation Circuit

    Science.gov (United States)

    Jones, Hollis; Racette, Paul; Walker, David; Gu, Dazhen

    2011-01-01

    A receiver gain modulation circuit (RGMC) was developed that modulates the power gain of the output of a radiometer receiver with a test signal. As the radiometer receiver switches between calibration noise references, the test signal is mixed with the calibrated noise and thus produces an ensemble set of measurements from which ensemble statistical analysis can be used to extract statistical information about the test signal. The RGMC is an enabling technology of the ensemble detector. As a key component for achieving ensemble detection and analysis, the RGMC has broad aeronautical and space applications. The RGMC can be used to test and develop new calibration algorithms, for example, to detect gain anomalies, and/or correct for slow drifts that affect climate-quality measurements over an accelerated time scale. A generalized approach to analyzing radiometer system designs yields a mathematical treatment of noise reference measurements in calibration algorithms. By treating the measurements from the different noise references as ensemble samples of the receiver state, i.e. receiver gain, a quantitative description of the non-stationary properties of the underlying receiver fluctuations can be derived. Excellent agreement has been obtained between model calculations and radiometric measurements. The mathematical formulation is equivalent to modulating the gain of a stable receiver with an externally generated signal and is the basis for ensemble detection and analysis (EDA). The concept of generating ensemble data sets using an ensemble detector is similar to the ensemble data sets generated as part of ensemble empirical mode decomposition (EEMD) with exception of a key distinguishing factor. EEMD adds noise to the signal under study whereas EDA mixes the signal with calibrated noise. It is mixing with calibrated noise that permits the measurement of temporal-functional variability of uncertainty in the underlying process. The RGMC permits the evaluation of EDA by

  2. Geochemical analysis of soils and sediments, Coeur d'Alene drainage basin, Idaho: sampling, analytical methods, and results

    Science.gov (United States)

    Box, Stephen E.; Bookstrom, Arthur A.; Ikramuddin, Mohammed; Lindsay, James

    2001-01-01

    This report presents the locations, descriptions, analytical procedures used, and an inter-lab comparison of over 1100 geochemical analyses of samples of soil and sediment in and downstream of a major lead-zinc-silver mining district in the Coeur d'Alene (CdA) drainage basin of northern Idaho. The samples fall in 3 broad categories: (1) samples from vertical profiles of floodplain soils in the valley of the main stem of the CdA River (767 samples) and of the South Fork of the CdA River (38 samples), (2) size fractionated surficial samples of sediment bedload within the channel of the South Fork of the CdA River (68 samples), and (3) samples from vertical profiles of sediment bedload within the channel of the main stem of the CdA River (260 samples). Five different laboratories contributed geochemical data for this report. Four of the five laboratories employed analytical methods that require sample dissolution prior to analysis; one laboratory (US Geological Survey) used analytical instrumentation (energy dispersive x-ray fluorescence [EDXRF]) that is applied to pulverized samples. Some dissolution procedures use four acids (hydrochloric, nitric, perchloric, and hydrofluoric; Eastern Washington University [EWU] Geochemical Laboratory and XRAL Laboratories, Inc.), others use two acids (nitric acid and aqua regia; CHEMEX Labs, Inc.), and some use only concentrated nitric acid (ACZ Laboratories, Inc.). Most analyses of dissolved samples were done by Inductively Coupled Plasma - Atomic Emission Spectroscopy (ICP-AES) or by ICP - MS (Mass Spectroscopy). Some analyses for Ag and K were done by Flame Atomic Absorption (FAA). Inter-laboratory comparisons are made for 6 elements: lead (Pb), zinc (Zn), iron

  3. Experimental evaluation of underride analysis techniques and empirical validation of a new analytical technique.

    Science.gov (United States)

    Boggess, Brian M; Morr, Douglas R; Peterman, Elaine K; Wiechel, John F

    2010-01-01

    Accident reconstructionists are often faced with damage patterns and locations on vehicles that are not well defined by available barrier impact data. One such example is a frontal underride collision. Underride impacts occur when there is a height mismatch between the primary structural components of the impacting vehicles, and the vehicle with the lower height is forced beneath the structure of the other vehicle. The lack of structural engagement typically allows for significantly different damage patterns due to the inherently lower stiffness of the underriding vehicle's contacting surfaces coupled with complex interactions between varying surfaces. In this study, a series of two-vehicle impact tests between a small pickup (bullet vehicle) and a large dump truck (target vehicle) were performed and studied. These tests involved a severe underride configuration in which the dump truck bed's vertical alignment was above the base of the windshield of the pickup. Coupled with these impacting surfaces was a single vertical support, a remnant of a commonly referred to ICC (Interstate Commerce Commission) bumper, which caused a narrow object-type impact, but did not extend down to the pickup's bumper. Multiple prior authors' analytical and empirical relationships to predict impact speed based on crush damage were evaluated using the results of these tests as well as other published underride tests. No single model was sufficient at predicting the mixed mode of impact present in these impact scenarios. However, a system of equations was developed to predict the impact parameters utilizing a combination of previously reported methods and a new empirical relationship presented in this study. This new method shows high correlation and supports the authors' hypothesis that separate crush models can be applied to multiple discrete areas of a vehicle and then combined to form a more complete predictive systematic model.

  4. Analysis of plasticizers in PVC medical devices: Performance comparison of eight analytical methods.

    Science.gov (United States)

    Bernard, L; Bourdeaux, D; Pereira, B; Azaroual, N; Barthélémy, C; Breysse, C; Chennell, P; Cueff, R; Dine, T; Eljezi, T; Feutry, F; Genay, S; Kambia, N; Lecoeur, M; Masse, M; Odou, P; Radaniel, T; Simon, N; Vaccher, C; Verlhac, C; Yessad, M; Décaudin, B; Sautou, V

    2017-01-01

    A wide variety of medical devices (MDs) used in hospitals are made of flexible plasticized polyvinylchloride (PVC). Different plasticizers are present in variable amounts in the PVC matrix of the devices and can leach out into the infused solutions and may enter into contact with the patients. The ARMED 1 project aims to assess the migration of these plasticizers from medical devices and therefore the level of exposure in patients. For the first task of the project, eight methods were developed to directly detect and quantify the plasticizers in the PVC matrix of the MDs. We compared the overall performances of the analytical methods using standardized and validated criteria in order to provide the scientific community with the guidance and the technical specifications of each method for the intended application. We have shown that routine rapid screening could be performed directly on the MDs using the FTIR technique, with cost-effective analyses. LC techniques may also be used, but with limits and only with individual quantification of the main plasticizers expected in the PVC matrix. GC techniques, especially GC-MS, are both more specific and more sensitive than other techniques. NMR is a robust and specific technique to precisely discriminate all plasticizers in a MD but is limited by its cost and its low ability to detect and quantify plasticizer contamination, e.g. by DEHP. All these results have been confirmed by a real test, called the " blind test " carried out on 10 MD samples. Copyright © 2016 Elsevier B.V. All rights reserved.

  5. Fuzzy surfaces in GIS and geographical analysis theory, analytical methods, algorithms and applications

    CERN Document Server

    Lodwick, Weldon

    2007-01-01

    Surfaces are a central to geographical analysis. Their generation and manipulation are a key component of geographical information systems (GISs). However, geographical surface data is often not precise. When surfaces are used to model geographical entities, the data inherently contains uncertainty in terms of both position and attribute. Fuzzy Surface in GIS and Geographical Analysis sets out a process to identify the uncertainty in geographic entities. It describes how to successfully obtain, model, analyze, and display data, as well as interpret results within the context of GIS. Focusing on uncertainty that arises from transitional boundaries, the book limits its study to three types of uncertainties: intervals, fuzzy sets, and possibility distributions. The book explains that uncertainty in geographical data typically stems from these three and it is only natural to incorporate them into the analysis and display of surface data. The book defines the mathematics associated with each method for analysis,...

  6. Collective Inference based Data Analytics System for Post Operations Analysis, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Current-day capabilities for performing post operations analysis (POA) of air traffic operations at airports, airlines and FAA facilities are mostly limited to...

  7. Mechanisms and mediation in survival analysis: towards an integrated analytical framework.

    LENUS (Irish Health Repository)

    Haase, Trutz

    2016-02-29

    A wide-ranging debate has taken place in recent years on mediation analysis and causal modelling, raising profound theoretical, philosophical and methodological questions. The authors build on the results of these discussions to work towards an integrated approach to the analysis of research questions that situate survival outcomes in relation to complex causal pathways with multiple mediators. The background to this contribution is the increasingly urgent need for policy-relevant research on the nature of inequalities in health and healthcare.

  8. Spatial Analysis in Determination Of Flood Prone Areas Using Geographic Information System and Analytical Hierarchy Process at Sungai Sembrong's Catchment

    Science.gov (United States)

    Bukari, S. M.; Ahmad, M. A.; Wai, T. L.; Kaamin, M.; Alimin, N.

    2016-07-01

    Floods that struck Johor state in 2006 and 2007 and the East Coastal in 2014 have triggered a greatly impact to the flood management here in Malaysia. Accordingly, this study conducted to determine potential areas of flooding, especially in Batu Pahat district since it faces terrifying experienced with heavy flood. This objective is archived by using the application of Geographic Information Systems (GIS) on study area of flood risk location at the watershed area of Sungai Sembrong. GIS functions as spatial analysis is capable to produce new information based on analysis of data stored in the system. Meanwhile the Analytical Hierarchy Process (AHP) was used as a method for setting up in decision making concerning the existing data. By using AHP method, preparation and position of the criteria and parameters required in GIS are neater and easier to analyze. Through this study, a flood prone area in the watershed of Sungai Sembrong was identified with the help of GIS and AHP. Analysis was conducted to test two different cell sizes, which are 30 and 5. The analysis of flood prone areas were tested on both cell sizes with two different water levels and the results of the analysis were displayed by GIS. Therefore, the use of AHP and GIS are effective and able to determine the potential flood plain areas in the watershed area of Sungai Sembrong.

  9. Analytical and numerical analysis of charge carriers extracted by linearly increasing voltage in a metal-insulator-semiconductor structure relevant to bulk heterojunction organic solar cells

    Science.gov (United States)

    Yumnam, Nivedita; Hirwa, Hippolyte; Wagner, Veit

    2017-12-01

    Analysis of charge extraction by linearly increasing voltage is conducted on metal-insulator-semiconductor capacitors in a structure relevant to organic solar cells. For this analysis, an analytical model is developed and is used to determine the conductivity of the active layer. Numerical simulations of the transient current were performed as a way to confirm the applicability of our analytical model and other analytical models existing in the literature. Our analysis is applied to poly(3-hexylthiophene)(P3HT) : phenyl-C61-butyric acid methyl ester (PCBM) which allows to determine the electron and hole mobility independently. A combination of experimental data analysis and numerical simulations reveals the effect of trap states on the transient current and where this contribution is crucial for data analysis.

  10. A comparative Thermal Analysis of conventional parabolic receiver tube and Cavity model tube in a Solar Parabolic Concentrator

    Science.gov (United States)

    Arumugam, S.; Ramakrishna, P.; Sangavi, S.

    2018-02-01

    Improvements in heating technology with solar energy is gaining focus, especially solar parabolic collectors. Solar heating in conventional parabolic collectors is done with the help of radiation concentration on receiver tubes. Conventional receiver tubes are open to atmosphere and loose heat by ambient air currents. In order to reduce the convection losses and also to improve the aperture area, we designed a tube with cavity. This study is a comparative performance behaviour of conventional tube and cavity model tube. The performance formulae were derived for the cavity model based on conventional model. Reduction in overall heat loss coefficient was observed for cavity model, though collector heat removal factor and collector efficiency were nearly same for both models. Improvement in efficiency was also observed in the cavity model’s performance. The approach towards the design of a cavity model tube as the receiver tube in solar parabolic collectors gave improved results and proved as a good consideration.

  11. Is food allergen analysis flawed? Health and supply chain risks and a proposed framework to address urgent analytical needs.

    Science.gov (United States)

    Walker, M J; Burns, D T; Elliott, C T; Gowland, M H; Mills, E N Clare

    2016-01-07

    Food allergy is an increasing problem for those affected, their families or carers, the food industry and for regulators. The food supply chain is highly vulnerable to fraud involving food allergens, risking fatalities and severe reputational damage to the food industry. Many facets are being pursued to ameliorate the difficulties including better food labelling and the concept of thresholds of elicitation of allergy symptoms as risk management tools. These efforts depend to a high degree on the ability reliably to detect and quantify food allergens; yet all current analytical approaches exhibit severe deficiencies that jeopardise accurate results being produced particularly in terms of the risks of false positive and false negative reporting. If we fail to realise the promise of current risk assessment and risk management of food allergens through lack of the ability to measure food allergens reproducibly and with traceability to an international unit of measurement, the analytical community will have failed a significant societal challenge. Three distinct but interrelated areas of analytical work are urgently needed to address the substantial gaps identified: (a) a coordinated international programme for the production of properly characterised clinically relevant reference materials and calibrants for food allergen analysis; (b) an international programme to widen the scope of proteomics and genomics bioinformatics for the genera containing the major allergens to address problems in ELISA, MS and DNA methods; (c) the initiation of a coordinated international programme leading to reference methods for allergen proteins that provide results traceable to the SI. This article describes in more detail food allergy, the risks of inapplicable or flawed allergen analyses with examples and a proposed framework, including clinically relevant incurred allergen concentrations, to address the currently unmet and urgently required analytical requirements. Support for the

  12. Analysis of environmental contamination resulting from catastrophic incidents: part 2. Building laboratory capability by selecting and developing analytical methodologies.

    Science.gov (United States)

    Magnuson, Matthew; Campisano, Romy; Griggs, John; Fitz-James, Schatzi; Hall, Kathy; Mapp, Latisha; Mullins, Marissa; Nichols, Tonya; Shah, Sanjiv; Silvestri, Erin; Smith, Terry; Willison, Stuart; Ernst, Hiba

    2014-11-01

    Catastrophic incidents can generate a large number of samples of analytically diverse types, including forensic, clinical, environmental, food, and others. Environmental samples include water, wastewater, soil, air, urban building and infrastructure materials, and surface residue. Such samples may arise not only from contamination from the incident but also from the multitude of activities surrounding the response to the incident, including decontamination. This document summarizes a range of activities to help build laboratory capability in preparation for sample analysis following a catastrophic incident, including selection and development of fit-for-purpose analytical methods for chemical, biological, and radiological contaminants. Fit-for-purpose methods are those which have been selected to meet project specific data quality objectives. For example, methods could be fit for screening contamination in the early phases of investigation of contamination incidents because they are rapid and easily implemented, but those same methods may not be fit for the purpose of remediating the environment to acceptable levels when a more sensitive method is required. While the exact data quality objectives defining fitness-for-purpose can vary with each incident, a governing principle of the method selection and development process for environmental remediation and recovery is based on achieving high throughput while maintaining high quality analytical results. This paper illustrates the result of applying this principle, in the form of a compendium of analytical methods for contaminants of interest. The compendium is based on experience with actual incidents, where appropriate and available. This paper also discusses efforts aimed at adaptation of existing methods to increase fitness-for-purpose and development of innovative methods when necessary. The contaminants of interest are primarily those potentially released through catastrophes resulting from malicious activity

  13. The magnetic particle in a box: Analytic and micromagnetic analysis of probe-localized spin wave modes

    Science.gov (United States)

    Adur, Rohan; Du, Chunhui; Manuilov, Sergei A.; Wang, Hailong; Yang, Fengyuan; Pelekhov, Denis V.; Hammel, P. Chris

    2015-05-01

    The dipole field from a probe magnet can be used to localize a discrete spectrum of standing spin wave modes in a continuous ferromagnetic thin film without lithographic modification to the film. Obtaining the resonance field for a localized mode is not trivial due to the effect of the confined and inhomogeneous magnetization precession. We compare the results of micromagnetic and analytic methods to find the resonance field of localized modes in a ferromagnetic thin film, and investigate the accuracy of these methods by comparing with a numerical minimization technique that assumes Bessel function modes with pinned boundary conditions. We find that the micromagnetic technique, while computationally more intensive, reveals that the true magnetization profiles of localized modes are similar to Bessel functions with gradually decaying dynamic magnetization at the mode edges. We also find that an analytic solution, which is simple to implement and computationally much faster than other methods, accurately describes the resonance field of localized modes when exchange fields are negligible, and demonstrating the accessibility of localized mode analysis.

  14. Analytical framework for the analysis/assessment of transition scenarios to sustainable nuclear energy systems and its applications

    International Nuclear Information System (INIS)

    Kuznetsov, V.

    2013-01-01

    IAEA/INPRO (in cooperation with the IAEA's Planning and Economic Studies Section) have developed an internationally verified analytical framework to assist Member States in Nuclear energy development modelling, including material flow analysis, economic assessment and least cost model optimization (IAEA Nuclear Energy Series No. NP-T-1.14 in print). The INPRO Group (in cooperation with the IAEA's Planning and Economic Studies Section) provides training to Member States on mastering and application of this analytical framework to particular problems of national/ collaborative nuclear energy development. For small programmes of the fast reactors/closed nuclear fuel cycle deployment the economic benefits from their introduction would be substantially lower than the amount of investments needed for RD&D, licensing and deployment. Only a few countries in the world with large nuclear energy programmes (30 GW(e) for fast reactors) can bear the burden of the technology development for fast reactors/closed nuclear fuel cycle. Therefore, global nuclear energy system would follow a heterogeneous world model, at least, within the present century

  15. Development of integrated analytical data management system

    International Nuclear Information System (INIS)

    Onishi, Koichi; Wachi, Isamu; Hiroki, Toshio

    1986-01-01

    The Analysis Subsection of Technical Service Section, Tokai Reprocessing Plant, Tokai Works, is engaged in analysis activities required for the management of processes and measurements in the plant. Currently, it has been desired to increase the reliability of analytical data and to perform analyses more rapidly to cope with the increasing number of analysis works. To meet this end, on-line data processing has been promoted and advanced analytical equipment has been introduced in order to enhance automization. In the present study, an integrated analytical data mangement system is developed which serves for improvement of reliability of analytical data as well as for rapid retrieval and automatic compilation of these data. Fabrication of a basic model of the system has been nearly completed and test operation has already been started. In selecting hardware to be used, examinations were made on easiness of system extension, Japanese language processing function for improving man-machine interface, large-capacity auxiliary memory system, and data base processing function. The existing analysis works wer reviewed in establishing the basic design of the system. According to this basic design, the system can perform such works as analysis of application slips received from clients as well as recording, sending, filing and retrieval of analysis results. (Nogami, K.)

  16. Multiplexed analysis combining distinctly-sized CdTe-MPA quantum dots and chemometrics for multiple mutually interfering analyte determination.

    Science.gov (United States)

    Bittar, Dayana B; Ribeiro, David S M; Páscoa, Ricardo N M J; Soares, José X; Rodrigues, S Sofia M; Castro, Rafael C; Pezza, Leonardo; Pezza, Helena R; Santos, João L M

    2017-11-01

    Semiconductor quantum dots (QDs) have demonstrated a great potential as fluorescent probes for heavy metals monitoring. However, their great reactivity, whose tunability could be difficult to attain, could impair selectivity yielding analytical results with poor accuracy. In this work, the combination in the same analysis of multiple QDs, each with a particular ability to interact with the analyte, assured a multi-point detection that was not only exploited for a more precise analyte discrimination but also for the simultaneous discrimination of multiple mutually interfering species, in the same sample. Three different MPA-CdTe QDs (2.5, 3.0 and 3.8nm) with a good size distribution, confirmed by the FWHM values of 48.6, 55.4 and 80.8nm, respectively, were used. Principal component analysis (PCA) and partial least squares regression (PLS) were used for fluorescence data analysis. Mixtures of two MPA-CdTe QDs, emitting at different wavelength namely 549/566, 549/634 and 566/634nm were assayed. The 549/634nm emitting QDs mixture provided the best results for the discrimination of distinct ions on binary and ternary mixtures. The obtained RMSECV and R 2 CV values for the binary mixture were good, namely, from 0.01 to 0.08mgL -1 and from 0.74 to 0.89, respectively. Regarding the ternary mixture the RMSECV and R 2 CV values were good for Hg(II) (0.06 and 0.73mgL -1 , respectively) and Pb(II) (0.08 and 0.87mg L -1 , respectively) and acceptable for Cu(II) (0.02 and 0.51mgL -1 , respectively). In conclusion, the obtained results showed that the developed approach is capable of resolve binary and ternary mixtures of Pb (II), Hg (II) and Cu (II), providing accurate information about lead (II) and mercury (II) concentration and signaling the occurrence of Cu (II). Copyright © 2017 Elsevier B.V. All rights reserved.

  17. Analysis of impact of “strong DC and weak AC” on receiving-end power system

    Science.gov (United States)

    Wang, Qiang; Li, Tianran; Yang, Pengcheng

    2018-02-01

    The rapid development of UHVDC transmission project has brought abundant power supply to the receiving-end power system area, but also many security and stability problems. This paper summarizes four elements that affect the strength of AC system, and then simulates the most basic two-terminal single-pole UHV transmission system by MATLAB/Simulink. It analyses the impact of receiving-end AC power system strength on real-time power, frequency and voltage. Finally, in view of operation risk of “strong DC and weak AC”, this paper puts forward three countermeasures.

  18. Uncertainty in soil-structure interaction analysis arising from differences in analytical techniques

    International Nuclear Information System (INIS)

    Maslenikov, O.R.; Chen, J.C.; Johnson, J.J.

    1982-07-01

    This study addresses uncertainties arising from variations in different modeling approaches to soil-structure interaction of massive structures at a nuclear power plant. To perform a comprehensive systems analysis, it is necessary to quantify, for each phase of the traditional analysis procedure, both the realistic seismic response and the uncertainties associated with them. In this study two linear soil-structure interaction techniques were used to analyze the Zion, Illinois nuclear power plant: a direct method using the FLUSH computer program and a substructure approach using the CLASSI family of computer programs. In-structure response from two earthquakes, one real and one synthetic, was compared. Structure configurations from relatively simple to complicated multi-structure cases were analyzed. The resulting variations help quantify uncertainty in structure response due to analysis procedures

  19. Concept mapping and network analysis: an analytic approach to measure ties among constructs.

    Science.gov (United States)

    Goldman, Alyssa W; Kane, Mary

    2014-12-01

    Group concept mapping is a mixed-methods approach that helps a group visually represent its ideas on a topic of interest through a series of related maps. The maps and additional graphics are useful for planning, evaluation and theory development. Group concept maps are typically described, interpreted and utilized through points, clusters and distances, and the implications of these features in understanding how constructs relate to one another. This paper focuses on the application of network analysis to group concept mapping to quantify the strength and directionality of relationships among clusters. The authors outline the steps of this analysis, and illustrate its practical use through an organizational strategic planning example. Additional benefits of this analysis to evaluation projects are also discussed, supporting the overall utility of this supplemental technique to the standard concept mapping methodology. Copyright © 2014 Elsevier Ltd. All rights reserved.

  20. A harmonic analysis approach to joint inversion of P-receiver functions and wave dispersion data in high dense seismic profiles

    Science.gov (United States)

    Molina-Aguilera, A.; Mancilla, F. D. L.; Julià, J.; Morales, J.

    2017-12-01

    Joint inversion techniques of P-receiver functions and wave dispersion data implicitly assume an isotropic radial stratified earth. The conventional approach invert stacked radial component receiver functions from different back-azimuths to obtain a laterally homogeneous single-velocity model. However, in the presence of strong lateral heterogeneities as anisotropic layers and/or dipping interfaces, receiver functions are considerably perturbed and both the radial and transverse components exhibit back azimuthal dependences. Harmonic analysis methods exploit these azimuthal periodicities to separate the effects due to the isotropic flat-layered structure from those effects caused by lateral heterogeneities. We implement a harmonic analysis method based on radial and transverse receiver functions components and carry out a synthetic study to illuminate the capabilities of the method in isolating the isotropic flat-layered part of receiver functions and constrain the geometry and strength of lateral heterogeneities. The independent of the baz P receiver function are jointly inverted with phase and group dispersion curves using a linearized inversion procedure. We apply this approach to high dense seismic profiles ( 2 km inter-station distance, see figure) located in the central Betics (western Mediterranean region), a region which has experienced complex geodynamic processes and exhibit strong variations in Moho topography. The technique presented here is robust and can be applied systematically to construct a 3-D model of the crust and uppermost mantle across large networks.

  1. Dispersion analysis of guided waves in the finned tube using the semi-analytical finite element method

    Science.gov (United States)

    Cong, Ming; Wu, Xinjun; Liu, Ran

    2017-08-01

    To increase heat exchange efficiency, finned tubes are widely used in petrochemical facilities. Recently, the application of guided wave testing to finned tube inspection has received attention. Since dispersion curves have not been obtained, the guided wave propagation process is still not clearly understood. Hence, the purpose of this paper is to calculate dispersion curves of the finned tube based on an accurate theoretical model, then features of guided waves propagating in finned tubes are further investigated. As fins are helicoidally welded around the outer surface of the tube with an equal interval, the semi-analytical finite element method is extended to this geometrically periodic waveguide. The shape of the discretized cross section is determined by geometric parameters of the finned tube. Numerical solutions show that group velocities of longitudinal modes in finned tubes are significantly slower than those in bare tubes and a special phenomenon of frequency pass bands and stop bands is presented. The changes of dispersion curves are also investigated with various geometric parameters of fins. Besides, torsional modes cannot propagate in finned tubes. By using an electromagnetic acoustic transducer, experimental results are in good agreement with numerical solutions, which indicates features of the guided wave propagation in finned tubes can be well predicted based on the proposed theoretical model.

  2. Análisis de las curvas receiver-operating characteristic: un método útil para evaluar procederes diagnósticos Analysis of receiver -operating characteristic curves: A useful method for assessing diagnostic procedures

    Directory of Open Access Journals (Sweden)

    Emma Domínguez Alonso

    2002-08-01

    Full Text Available Se sabe que los procederes diagnósticos son parte esencial y crítica en la toma de decisiones clínicas, de ahí la importancia de evaluar su precisión diagnóstica. El análisis de las curvas Receiver-Operating Characteristic aporta, de manera sencilla, un magnífico indicador de la precisión de una prueba diagnóstica. En este trabajo se consideraron aspectos, fundamentalmente prácticos, relativos a la metodología Receiver-Operating Characteristic como: utilidad, modo de interpretar los resultados y ventajas en relación con otros métodos. Se concluyó que el conocimiento sobre esta metodología resulta de gran utilidad para todo profesional de la salud encargado de desarrollar, validar, indicar e interpretar resultados de pruebas diagnósticas.AS the diagnostic procedures are an essential and critical part at the time of making clinical decisions, it is very important to evaluate their diagnostic accuracy. The analysis of the Receiver-Operating Characteristic curves offers in a simple way an excellent indicator of precision of a diagnostic test. In this paper, mainly practical aspects connected with ROC methodology, such as usefulness, way of interpreting the results and advantages in relation to other methods, are considered. It is concluded that the knowledge on this methodology is very useful for every health professional in charge of developing, validating, indicating and interpreting the results of the diagnostic tests.

  3. Information-analytical system for a comprehensive assessment and analysis of the enterprises

    Directory of Open Access Journals (Sweden)

    Baydybekova Saltanat Kenzhebaevna

    2015-04-01

    Lack of theoretical elaboration and high practical significance the problem of forming the system of internal control and analysis of economic organizations, the need for further development of his theory, methodology and organization, as well as great practical relevance in specific methods and techniques for its implementation led to the choice of research topic and its relevance.

  4. The Effect of Gender on Organizational Commitment of Teachers: A Meta Analytic Analysis

    Science.gov (United States)

    Aydin, Ayhan; Sarier, Yilmaz; Uysal, Sengul

    2011-01-01

    The purpose of this study is to determine the effect of gender on the organizational commitment of teachers. In this respect, the levels of organizational commitment were also investigated with organizational commitment. Fifteen master and doctorate theses done between 2005-2009 were analyzed using meta analysis. At the end of the research study,…

  5. Elasto-plastic strain analysis by a semi-analytical method

    Indian Academy of Sciences (India)

    required to be addressed to make the engineering design as competitive as possible. Again the ... Abdalla et al (2006) presented a simplified technique to determine the shakedown limit load of a structure using the ... process was found to be more accurate and economic than the commercial finite element analysis software ...

  6. Black Boxes in Analytical Chemistry: University Students' Misconceptions of Instrumental Analysis

    Science.gov (United States)

    Carbo, Antonio Domenech; Adelantado, Jose Vicente Gimeno; Reig, Francisco Bosch

    2010-01-01

    Misconceptions of chemistry and chemical engineering university students concerning instrumental analysis have been established from coordinated tests, tutorial interviews and laboratory lessons. Misconceptions can be divided into: (1) formal, involving specific concepts and formulations within the general frame of chemistry; (2)…

  7. A REVISED SOLAR TRANSFORMITY FOR TIDAL ENERGY RECEIVED BY THE EARTH AND DISSIPATED GLOBALLY: IMPLICATIONS FOR EMERGY ANALYSIS

    Science.gov (United States)

    Solar transformities for the tidal energy received by the earth and the tidal energy dissipated globally can be calculated because both solar energy and the gravitational attraction of the sun and moon drive independent processes that produce an annual flux of geopotential energy...

  8. The crust and mantle beneath the Siberian provinces: a preliminary model based on new receiver function analysis

    DEFF Research Database (Denmark)

    Soliman, Mohammad Youssof Ahmad; Artemieva, Irina; Thybo, Hans

    2012-01-01

    The new receiver function (RF) study complements the existing seismic data on the crustal and upper mantle structure at the margins of the Siberian craton and the West Siberian Basin. So far, RF studies of Siberia have been largely restricted to the Baikal rift zone (Gao et al., 2004; Liu and Gao...

  9. Analytic geometry

    CERN Document Server

    Burdette, A C

    1971-01-01

    Analytic Geometry covers several fundamental aspects of analytic geometry needed for advanced subjects, including calculus.This book is composed of 12 chapters that review the principles, concepts, and analytic proofs of geometric theorems, families of lines, the normal equation of the line, and related matters. Other chapters highlight the application of graphing, foci, directrices, eccentricity, and conic-related topics. The remaining chapters deal with the concept polar and rectangular coordinates, surfaces and curves, and planes.This book will prove useful to undergraduate trigonometric st

  10. Heat transfer analysis of a volumetric solar receiver by coupling the solar radiation transport and internal heat transfer

    International Nuclear Information System (INIS)

    Chen, Xue; Xia, Xin-Lin; Liu, Hua; Li, Yang; Liu, Bo

    2016-01-01

    Highlights: • A model coupling solar radiation transport and internal heat transfer is developed. • Two other treatment approaches for the concentrated solar radiation are compared. • Porous parameters significantly affect the distribution of absorbed solar radiation. • The TBC approach overestimates the solid temperature with a deviation up to 76.4%. • The CIR approach provides acceptable temperature field with deviation less than 3.4%. - Abstract: Volumetric receivers have become a promising technology for the solar thermal conversion. The absorption of concentrated solar radiation and the heat transfer to the working fluid are the two dominant processes. To effectively investigate the thermal performance of receiver, a numerical model coupling the solar radiation transport and the internal heat transfer is presented. Solar radiation transport from the dish concentrator to the interior of receiver is simulated with the Monte Carlo ray tracing method. Combining the distribution of absorbed solar energy in the receiver, the local thermal non-equilibrium model with P1 approximation is used to solve the internal heat transfer. Two other treatment approaches for the concentrated solar radiation are compared. One considers the solar radiation on the front surface of receiver as thermal boundary condition (TBC) and the other as a collimated incident radiation (CIR) beam. The results show that the porosity and mean cell size have a great effect on the distribution of absorbed solar radiation. Compared with the coupling approach, the TBC approach overestimates the solid temperature near the front surface with a deviation up to 76.4%, while the CIR approach provides acceptable temperature field with a deviation less than 3.4%. In addition, the fluid and solid temperatures both decrease as the slope error of concentrator increases.

  11. Systematic differences in signal emitting and receiving revealed by PageRank analysis of a human protein interactome.

    Directory of Open Access Journals (Sweden)

    Donglei Du

    Full Text Available Most protein PageRank studies do not use signal flow direction information in protein interactions because this information was not readily available in large protein databases until recently. Therefore, four questions have yet to be answered: A What is the general difference between signal emitting and receiving in a protein interactome? B Which proteins are among the top ranked in directional ranking? C Are high ranked proteins more evolutionarily conserved than low ranked ones? D Do proteins with similar ranking tend to have similar subcellular locations? In this study, we address these questions using the forward, reverse, and non-directional PageRank approaches to rank an information-directional network of human proteins and study their evolutionary conservation. The forward ranking gives credit to information receivers, reverse ranking to information emitters, and non-directional ranking mainly to the number of interactions. The protein lists generated by the forward and non-directional rankings are highly correlated, but those by the reverse and non-directional rankings are not. The results suggest that the signal emitting/receiving system is characterized by key-emittings and relatively even receivings in the human protein interactome. Signaling pathway proteins are frequent in top ranked ones. Eight proteins are both informational top emitters and top receivers. Top ranked proteins, except a few species-related novel-function ones, are evolutionarily well conserved. Protein-subunit ranking position reflects subunit function. These results demonstrate the usefulness of different PageRank approaches in characterizing protein networks and provide insights to protein interaction in the cell.

  12. Systematic differences in signal emitting and receiving revealed by PageRank analysis of a human protein interactome.

    Science.gov (United States)

    Du, Donglei; Lee, Connie F; Li, Xiu-Qing

    2012-01-01

    Most protein PageRank studies do not use signal flow direction information in protein interactions because this information was not readily available in large protein databases until recently. Therefore, four questions have yet to be answered: A) What is the general difference between signal emitting and receiving in a protein interactome? B) Which proteins are among the top ranked in directional ranking? C) Are high ranked proteins more evolutionarily conserved than low ranked ones? D) Do proteins with similar ranking tend to have similar subcellular locations? In this study, we address these questions using the forward, reverse, and non-directional PageRank approaches to rank an information-directional network of human proteins and study their evolutionary conservation. The forward ranking gives credit to information receivers, reverse ranking to information emitters, and non-directional ranking mainly to the number of interactions. The protein lists generated by the forward and non-directional rankings are highly correlated, but those by the reverse and non-directional rankings are not. The results suggest that the signal emitting/receiving system is characterized by key-emittings and relatively even receivings in the human protein interactome. Signaling pathway proteins are frequent in top ranked ones. Eight proteins are both informational top emitters and top receivers. Top ranked proteins, except a few species-related novel-function ones, are evolutionarily well conserved. Protein-subunit ranking position reflects subunit function. These results demonstrate the usefulness of different PageRank approaches in characterizing protein networks and provide insights to protein interaction in the cell.

  13. A total analytical system featuring a novel solid-liquid extraction chamber for solid sample flow analysis.

    Science.gov (United States)

    Galvis-Sánchez, Andrea C; Santos, João Rodrigo; Rangel, António O S S

    2016-11-01

    In this work, a total flow analysis system based on a novel solid-liquid extraction chamber is presented. This strategy enables all the main experimental procedures for the analysis of a solid sample to be performed automatically: enrichment of the liquid extract, sample treatment, filtration of the liquid extract from the solid sample, directing the extract towards detection, and finally cleansing of the chamber for the following solid sample to be analyzed. The chamber designed to be incorporated in the flow manifold presents two main features: it accommodates stirring bars for enhancing the extraction process, and it presents replaceable solid sample containers (a spare part of the solid-liquid extraction chamber) to easily replace the solid sample and therefore enhance sample analysis throughput. The chamber performance was assessed using two different solid samples, an ion exchanger resin and vegetable samples, focussing on proton and nitrate ion extraction, respectively. The main figures of merit achieved were relative standard deviation (RSD) and relative error values below 7 % for all determinations. The determination rate for vegetable samples was ca. 12 samples h -1 . The proposed strategy may be exploited to perform automatically the analysis of solid samples as it embodies a simple automatic strategy of a very important but time-consuming and laborious analytical operation. Graphical abstract TAS for solid liquid extraction and nitrate potentiometric determination of vegetable samples.

  14. Diffusive transport of organic vapors in the unsaturated zone with kinetically-controlled volatilization and dissolution: analytical model and analysis

    Science.gov (United States)

    Zaidel, Jacob; Russo, David

    1994-12-01

    Kinetically-controlled volatilization and dissolution of nonaqueous-phase liquids (NAPL's) in the unsaturated (vadose) zone are a more general model as compared to the usually used local equilibrium model of mass transfer. This paper presents a one-dimensional vertical model of kinetically-controlled diffusive transport of organic vapors pertinent to pollution caused by a relatively long, ground surface-originating, mainly horizontally-spread leak of NAPL, the volatile compound of which undergoes sorption and degradation in the soil. Analytical solutions of this model are applicable to homogeneous soils with ground surface fully open to the atmosphere. Application of the solutions to several examples demonstrates the role of kinetically-controlled volatilization and dissolution at both early and advanced stages of the transport process. Asymptotic analysis of the outlined solutions is employed in order to examine the depletion of the contaminant source.

  15. Analytical solution for the free vibration analysis of delaminated Timoshenko beams.

    Science.gov (United States)

    Jafari-Talookolaei, Ramazan-Ali; Abedi, Maryam

    2014-01-01

    This work presents a method to find the exact solutions for the free vibration analysis of a delaminated beam based on the Timoshenko type with different boundary conditions. The solutions are obtained by the method of Lagrange multipliers in which the free vibration problem is posed as a constrained variational problem. The Legendre orthogonal polynomials are used as the beam eigenfunctions. Natural frequencies and mode shapes of various Timoshenko beams are presented to demonstrate the efficiency of the methodology.

  16. Analytical Solution for the Free Vibration Analysis of Delaminated Timoshenko Beams

    Directory of Open Access Journals (Sweden)

    Ramazan-Ali Jafari-Talookolaei

    2014-01-01

    Full Text Available This work presents a method to find the exact solutions for the free vibration analysis of a delaminated beam based on the Timoshenko type with different boundary conditions. The solutions are obtained by the method of Lagrange multipliers in which the free vibration problem is posed as a constrained variational problem. The Legendre orthogonal polynomials are used as the beam eigenfunctions. Natural frequencies and mode shapes of various Timoshenko beams are presented to demonstrate the efficiency of the methodology.

  17. Metabolomic analysis using porcine skin: a pilot study of analytical techniques

    OpenAIRE

    Wu, Julie; Fiehn, Oliver; Armstrong, April W

    2014-01-01

    Background: Metabolic byproducts serve as indicators of the chemical processes and can provide valuable information on pathogenesis by measuring the amplified output. Standardized techniques for metabolome extraction of skin samples serve as a critical foundation to this field but have not been developed. Objectives: We sought to determine the optimal cell lysage techniques for skin sample preparation and to compare GC-TOF-MS and UHPLC-QTOF-MS for metabolomic analysis. ...

  18. Comprehensive evaluation of coal-fired power plants based on grey relational analysis and analytic hierarchy process

    International Nuclear Information System (INIS)

    Xu Gang; Yang Yongping; Lu Shiyuan; Li Le; Song Xiaona

    2011-01-01

    In China, coal-fired power plants are the main supplier of electricity, as well as the largest consumer of coal and water resources and the biggest emitter of SO x , NO x , and greenhouse gases (GHGs). Therefore, it is important to establish a scientific, reasonable, and feasible comprehensive evaluation system for coal-fired power plants to guide them in achieving multi-optimisation of their thermal, environmental, and economic performance. This paper proposes a novel comprehensive evaluation method, which is based on a combination of the grey relational analysis (GRA) and the analytic hierarchy process (AHP), to assess the multi-objective performance of power plants. Unlike the traditional evaluation method that uses coal consumption as a basic indicator, the proposed evaluation method also takes water consumption and pollutant emissions as indicators. On the basis of the proposed evaluation method, a case study on typical 600 MW coal-fired power plants is carried out to determine the relevancy rules among factors including the coal consumption, water consumption, pollutant, and GHG emissions of power plants. This research offers new ideas and methods for the comprehensive performance evaluation of complex energy utilisation systems, and is beneficial to the synthesised consideration of resources, economy, and environment factors in system optimising and policy making. - Research highlights: → We proposed a comprehensive evaluation method for coal-fired power plants. → The method is based on the grey relational analysis (GRA). → The method also introduces the idea of the analytic hierarchy process (AHP). → The method can assess thermal, economic and environmental performance. → The method can play an active role in guiding power plants' improvements.

  19. Performance analysis of a Kalina cycle for a central receiver solar thermal power plant with direct steam generation

    International Nuclear Information System (INIS)

    Modi, Anish; Haglind, Fredrik

    2014-01-01

    Solar thermal power plants have attracted increasing interest in the past few years – with respect to both the design of the various plant components, and extending the operation hours by employing different types of storage systems. One approach to improve the overall plant efficiency is to use direct steam generation with water/steam as both the heat transfer fluid in the solar receivers and the cycle working fluid. This enables operating the plant with higher turbine inlet temperatures. Available literature suggests that it is feasible to use ammonia-water mixtures at high temperatures without corroding the equipment by using suitable additives with the mixture. The purpose of the study reported here was to investigate if there is any benefit of using a Kalina cycle for a direct steam generation, central receiver solar thermal power plant with high live steam temperature (450 °C) and pressure (over 100 bar). Thermodynamic performance of the Kalina cycle in terms of the plant exergy efficiency was evaluated and compared with a simple Rankine cycle. The rates of exergy destruction for the different components in the two cycles were also calculated and compared. The results suggest that the simple Rankine cycle exhibits better performance than the Kalina cycle when the heat input is only from the solar receiver. However, when using a two-tank molten-salt storage system as the primary source of heat input, the Kalina cycle showed an advantage over the simple Rankine cycle because of about 33 % reduction in the storage requirement. The solar receiver showed the highest rate of exergy destruction for both the cycles. The rates of exergy destruction in other components of the cycles were found to be highly dependent on the amount of recuperation, and the ammonia mass fraction and pressure at the turbine inlet. - Highlights: •Kalina cycle for a central receiver solar thermal power plant with direct steam generation. •Rankine cycle shows better plant exergy

  20. Use of reference materials for validating analytical methods. Applied to the determination of As, Co, Na, Hg, Se and Fe using neutron activation analysis

    International Nuclear Information System (INIS)

    Munoz, L; Andonie, O; Kohnenkamp, I

    2000-01-01

    The main purpose of an analytical laboratory is to provide reliable information on the nature and composition of the materials submitted for analysis. This purpose can only be attained if analytical methodologies that have the attributes of accuracy, precision, specificity and sensitivity, among others, are used. The process by which these attributes are evaluated is called validation of the analytical method. The Chilean Nuclear Energy Commission's Neutron Activation Analysis Laboratory is applying a quality guarantee program to ensure the quality of its analytical results, which aims, as well, to attain accreditation for some of its measurements. Validation of the analytical methodologies used is an essential part of applying this program. There are many forms of validation, from comparison with reference techniques to participation in inter-comparison rounds. Certified reference materials were used in this work in order to validate the application of neutron activation analysis in determining As, Co, Na, Hg, Se and Fe in shellfish samples. The use of reference materials was chosen because it is a simple option that easily detects sources of systematic errors. Neutron activation analysis is an instrumental analytical method that does not need chemical treatment and that is based on processes which take place in the nuclei of atoms, making the matrix effects unimportant and different biological reference materials can be used. The following certified reference materials were used for validating the method used: BCR human hair 397, NRCC dogfish muscle DORM-2, NRCC -dogfish liver DOLT-2, NIST - oyster tissue 1566, NIES - mussel 6 and BCR - tuna fish 464. The reference materials were analyzed using the procedure developed for the shellfish samples and the above-mentioned elements were determined. With the results obtained, the parameters of accuracy, precision, detection limit, quantification limit and uncertainty associated with the method were determined for each

  1. Metabolomic analysis using porcine skin: a pilot study of analytical techniques.

    Science.gov (United States)

    Wu, Julie; Fiehn, Oliver; Armstrong, April W

    2014-06-15

    Metabolic byproducts serve as indicators of the chemical processes and can provide valuable information on pathogenesis by measuring the amplified output. Standardized techniques for metabolome extraction of skin samples serve as a critical foundation to this field but have not been developed. We sought to determine the optimal cell lysage techniques for skin sample preparation and to compare GC-TOF-MS and UHPLC-QTOF-MS for metabolomic analysis. Using porcine skin samples, we pulverized the skin via various combinations of mechanical techniques for cell lysage. After extraction, the samples were subjected to GC-TOF-MS and/or UHPLC-QTOF-MS. Signal intensities from GC-TOF-MS analysis showed that ultrasonication (2.7x107) was most effective for cell lysage when compared to mortar-and-pestle (2.6x107), ball mill followed by ultrasonication (1.6x107), mortar-and-pestle followed by ultrasonication (1.4x107), and homogenization (trial 1: 8.4x106; trial 2: 1.6x107). Due to the similar signal intensities, ultrasonication and mortar-and-pestle were applied to additional samples and subjected to GC-TOF-MS and UHPLC-QTOF-MS. Ultrasonication yielded greater signal intensities than mortar-and-pestle for 92% of detected metabolites following GC-TOF-MS and for 68% of detected metabolites following UHPLC-QTOF-MS. Overall, ultrasonication is the preferred method for efficient cell lysage of skin tissue for both metabolomic platforms. With standardized sample preparation, metabolomic analysis of skin can serve as a powerful tool in elucidating underlying biological processes in dermatological conditions.

  2. Analytical Methods for Malachite Green : Completion Report : Malachite Green Analysis in Water.

    Energy Technology Data Exchange (ETDEWEB)

    Allen, John L.; Gofus, Jane E.; Meinertz, Jeffery R.

    1991-06-01

    Malachite green is a known teratogen and therefore its use is limited to nonfood fish under an Investigational New Animal Drug permit (INAD), number 2573. Although a charcoal adsorption column was developed to remove malachite green from hatchery water, INAD compliance requires that the malachite green residue concentrations in any effluent from hatcheries using the chemical be quantified. Therefore, we developed a method for the analysis of malachite green residues in water. Enrichment of the residues of malachite green in water on a diol column followed by High Performance Liquid Chromatographic (HPLC) analysis gives a minimum sensitivity of less than 10 ppb for the chemical. When combined with post-column oxidation using a lead oxide post-column reactor, the procedure can be used for the simultaneous analysis of malachite green in its leuco form, a decomposition product of the dye, as well as its chromatic form. Recovery of the leuco form is pH dependent and water samples should be adjusted to pH 6 to optimize recovery of this form. Water samples spiked with malachite green were concentrated on a diol column followed by elution with 0.05 M p-toluene sulfonic acid in methanol. The methanol elutes were analyzed by HPLC. Pond water samples spiked with malachite green and leuco malachite green yielded average recoveries of 95.4% for malachite green and 57.3% for leuco malachite green. Tap water samples spiked with the carbinol form of malachite green gave average recoveries of 98.6%. The method is very sensitive and is capable of detecting malachite green residues in water at less than 10 ppb. Fish culturists, who cannot find an effective replacement for malachite green, can utilize the method to ensure that their effluents comply with INAD regulations. 13 refs., 2 figs., 7 tabs.

  3. Analytical laboratory quality assurance guidance in support of EM environmental sampling and analysis activities

    International Nuclear Information System (INIS)

    1994-05-01

    This document introduces QA guidance pertaining to design and implementation of laboratory procedures and processes for collecting DOE Environmental Restoration and Waste Management (EM) ESAA (environmental sampling and analysis activities) data. It addresses several goals: identifying key laboratory issues and program elements to EM HQ and field office managers; providing non-prescriptive guidance; and introducing environmental data collection program elements for EM-263 assessment documents and programs. The guidance describes the implementation of laboratory QA elements within a functional QA program (development of the QA program and data quality objectives are not covered here)

  4. Performance analysis of a Kalina cycle for a central receiver solar thermal power plant with direct steam generation

    DEFF Research Database (Denmark)

    Modi, Anish; Haglind, Fredrik

    2014-01-01

    Solar thermal power plants have attracted increasing interest in the past few years - with respect to both the design of the various plant components, and extending the operation hours by employing different types of storage systems. One approach to improve the overall plant efficiency is to use...... that the simple Rankine cycle exhibits better performance than the Kalina cycle when the heat input is only from the solar receiver. However, when using a two-tank molten-salt storage system as the primary source of heat input, the Kalina cycle showed an advantage over the simple Rankine cycle because of about 33...... % reduction in the storage requirement. The solar receiver showed the highest rate of exergy destruction for both the cycles. The rates of exergy destruction in other components of the cycles were found to be highly dependent on the amount of recuperation, and the ammonia mass fraction and pressure...

  5. An Analysis of Language as a Barrier to Receiving Influenza Vaccinations among an Elderly Hispanic Population in the United States

    OpenAIRE

    Pearson, William S.; Zhao, Guixiang; Ford, Earl S.

    2010-01-01

    Background. The Hispanic population in the United States is growing, and disparities in the receipt of healthcare services as a result of limited English proficiency have been demonstrated. We set out to determine if Spanish language preference was a barrier to receiving influenza vaccinations among Hispanic persons 65 years and older in the USA. Methods. Differences in the receipt of vaccinations by language preference were tested with both Chi-square analyses and adjusted logistic regressio...

  6. Crustal structure beneath two seismic stations in the Sunda-Banda arc transition zone derived from receiver function analysis

    Energy Technology Data Exchange (ETDEWEB)

    Syuhada, E-mail: hadda9@gmail.com [Graduate Research on Earthquake and Active Tectonics (GREAT), Bandung Institute of Technology, Jalan Ganesha 10, Bandung 40132 (Indonesia); Research Centre for Physics - Indonesian Institute of Sciences (LIPI), Kompleks Puspiptek Serpong, Tangsel 15314, Banten Indonesia (Indonesia); Hananto, Nugroho D.; Handayani, Lina [Research Centre for Geotechnology - Indonesian Institute of Sciences (LIPI), Jl. Sangkuriang (Kompleks LIPI) Bandung 40135 (Indonesia); Puspito, Nanang T; Yudistira, Tedi [Faculty of Mining and Petroleum Engineering ITB, Jalan Ganesha 10, Bandung 40132 (Indonesia); Anggono, Titi [Research Centre for Physics - Indonesian Institute of Sciences (LIPI), Kompleks Puspiptek Serpong, Tangsel 15314, Banten Indonesia (Indonesia)

    2015-04-24

    We analyzed receiver functions to estimate the crustal thickness and velocity structure beneath two stations of Geofon (GE) network in the Sunda-Banda arc transition zone. The stations are located in two different tectonic regimes: Sumbawa Island (station PLAI) and Timor Island (station SOEI) representing the oceanic and continental characters, respectively. We analyzed teleseismic events of 80 earthquakes to calculate the receiver functions using the time-domain iterative deconvolution technique. We employed 2D grid search (H-κ) algorithm based on the Moho interaction phases to estimate crustal thickness and Vp/Vs ratio. We also derived the S-wave velocity variation with depth beneath both stations by inverting the receiver functions. We obtained that beneath station PLAI the crustal thickness is about 27.8 km with Vp/Vs ratio 2.01. As station SOEI is covered by very thick low-velocity sediment causing unstable solution for the inversion, we modified the initial velocity model by adding the sediment thickness estimated using high frequency content of receiver functions in H-κ stacking process. We obtained the crustal thickness is about 37 km with VP/Vs ratio 2.2 beneath station SOEI. We suggest that the high Vp/Vs in station PLAI may indicate the presence of fluid ascending from the subducted plate to the volcanic arc, whereas the high Vp/Vs in station SOEI could be due to the presence of sediment and rich mafic composition in the upper crust and possibly related to the serpentinization process in the lower crust. We also suggest that the difference in velocity models and crustal thicknesses between stations PLAI and SOEI are consistent with their contrasting tectonic environments.

  7. Space Trajectory Error Analysis Program (STEAP) for halo orbit missions. Volume 1: Analytic and user's manual

    Science.gov (United States)

    Byrnes, D. V.; Carney, P. C.; Underwood, J. W.; Vogt, E. D.

    1974-01-01

    Development, test, conversion, and documentation of computer software for the mission analysis of missions to halo orbits about libration points in the earth-sun system is reported. The software consisting of two programs called NOMNAL and ERRAN is part of the Space Trajectories Error Analysis Programs (STEAP). The program NOMNAL targets a transfer trajectory from Earth on a given launch date to a specified halo orbit on a required arrival date. Either impulsive or finite thrust insertion maneuvers into halo orbit are permitted by the program. The transfer trajectory is consistent with a realistic launch profile input by the user. The second program ERRAN conducts error analyses of the targeted transfer trajectory. Measurements including range, doppler, star-planet angles, and apparent planet diameter are processed in a Kalman-Schmidt filter to determine the trajectory knowledge uncertainty. Execution errors at injection, midcourse correction and orbit insertion maneuvers are analyzed along with the navigation uncertainty to determine trajectory control uncertainties and fuel-sizing requirements. The program is also capable of generalized covariance analyses.

  8. Identification of Chemical Attribution Signatures of Fentanyl Syntheses Using Multivariate Statistical Analysis of Orthogonal Analytical Data

    Energy Technology Data Exchange (ETDEWEB)

    Mayer, B. P. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Mew, D. A. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); DeHope, A. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Spackman, P. E. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Williams, A. M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2015-09-24

    Attribution of the origin of an illicit drug relies on identification of compounds indicative of its clandestine production and is a key component of many modern forensic investigations. The results of these studies can yield detailed information on method of manufacture, starting material source, and final product - all critical forensic evidence. In the present work, chemical attribution signatures (CAS) associated with the synthesis of the analgesic fentanyl, N-(1-phenylethylpiperidin-4-yl)-N-phenylpropanamide, were investigated. Six synthesis methods, all previously published fentanyl synthetic routes or hybrid versions thereof, were studied in an effort to identify and classify route-specific signatures. 160 distinct compounds and inorganic species were identified using gas and liquid chromatographies combined with mass spectrometric methods (GC-MS and LCMS/ MS-TOF) in conjunction with inductively coupled plasma mass spectrometry (ICPMS). The complexity of the resultant data matrix urged the use of multivariate statistical analysis. Using partial least squares discriminant analysis (PLS-DA), 87 route-specific CAS were classified and a statistical model capable of predicting the method of fentanyl synthesis was validated and tested against CAS profiles from crude fentanyl products deposited and later extracted from two operationally relevant surfaces: stainless steel and vinyl tile. This work provides the most detailed fentanyl CAS investigation to date by using orthogonal mass spectral data to identify CAS of forensic significance for illicit drug detection, profiling, and attribution.

  9. TCM-Mesh: The database and analytical system for network pharmacology analysis for TCM preparations.

    Science.gov (United States)

    Zhang, Run-Zhi; Yu, Shao-Jun; Bai, Hong; Ning, Kang

    2017-06-06

    With the advancement of systems biology research, we have already seen great progress in pharmacology studies, especially in network pharmacology. Network pharmacology has been proven to be effective for establishing the "compounds-proteins/genes-diseases" network, and revealing the regulation principles of small molecules in a high-throughput manner, thus would be very effective for the analysis of drug combinations, especially for TCM preparations. In this work, we have proposed the TCM-Mesh system, which records TCM-related information collected from various resources and could serve for network pharmacology analysis for TCM preparations in a high-throughput manner (http://mesh.tcm.microbioinformatics.org/). Currently, the database contains 6,235 herbs, 383,840 compounds, 14,298 genes, 6,204 diseases, 144,723 gene-disease associations, 3,440,231 pairs of gene interactions, 163,221 side effect records and 71 toxic records, and web-based software construct a network between herbs and treated diseases, which will help to understand the underlying mechanisms for TCM preparations at molecular levels. We have used 1,293 FDA-approved drugs, as well as compounds from an herbal material Panax ginseng and a patented drug Liuwei Dihuang Wan (LDW) for evaluating our database. By comparison of different databases, as well as checking against literature, we have demonstrated the completeness, effectiveness, and accuracy of our database.

  10. Applying green analytical chemistry for rapid analysis of drugs: Adding health to pharmaceutical industry

    Directory of Open Access Journals (Sweden)

    Nazrul Haq

    2017-02-01

    Full Text Available Green RP-HPLC method for a rapid analysis of olmesartan medoxomil (OLM in bulk drugs, self-microemulsifying drug delivery system (SMEDDS and marketed tablets was developed and validated in the present investigation. The chromatographic identification was achieved on Lichrosphere 250 × 4.0 mm RP C8 column having a 5 μm packing as a stationary phase using a combination of green solvents ethyl acetate:ethanol (50:50% v/v as a mobile phase, at a flow rate of 1.0 mL/min with UV detection at 250 nm. The proposed method was validated for linearity, selectivity, accuracy, precision, reproducibility, robustness, sensitivity and specificity. The utility of the proposed method was verified by an assay of OLM in SMEDDS and commercial tablets. The proposed method was found to be selective, precise, reproducible, accurate, robust, sensitive and specific. The amount of OLM in SMEDDS and commercial tablets was found to be 101.25% and 98.67% respectively. The proposed method successfully resolved OLM peak in the presence of its degradation products which indicated stability-indicating property of the proposed method. These results indicated that the proposed method can be successfully employed for a routine analysis of OLM in bulk drugs and commercial formulations.

  11. SASfit: a tool for small-angle scattering data analysis using a library of analytical expressions.

    Science.gov (United States)

    Breßler, Ingo; Kohlbrecher, Joachim; Thünemann, Andreas F

    2015-10-01

    SASfit is one of the mature programs for small-angle scattering data analysis and has been available for many years. This article describes the basic data processing and analysis workflow along with recent developments in the SASfit program package (version 0.94.6). They include (i) advanced algorithms for reduction of oversampled data sets, (ii) improved confidence assessment in the optimized model parameters and (iii) a flexible plug-in system for custom user-provided models. A scattering function of a mass fractal model of branched polymers in solution is provided as an example for implementing a plug-in. The new SASfit release is available for major platforms such as Windows, Linux and MacOS. To facilitate usage, it includes comprehensive indexed documentation as well as a web-based wiki for peer collaboration and online videos demonstrating basic usage. The use of SASfit is illustrated by interpretation of the small-angle X-ray scattering curves of monomodal gold nanoparticles (NIST reference material 8011) and bimodal silica nanoparticles (EU reference material ERM-FD-102).

  12. Decision making model design for antivirus software selection using Factor Analysis and Analytical Hierarchy Process

    Directory of Open Access Journals (Sweden)

    Nurhayati Ai

    2018-01-01

    Full Text Available Virus spread increase significantly through the internet in 2017. One of the protection method is using antivirus software. The wide variety of antivirus software in the market tends to creating confusion among consumer. Selecting the right antivirus according to their needs has become difficult. This is the reason we conduct our research. We formulate a decision making model for antivirus software consumer. The model is constructed by using factor analysis and AHP method. First we spread questionnaires to consumer, then from those questionnaires we identified 16 variables that needs to be considered on selecting antivirus software. This 16 variables then divided into 5 factors by using factor analysis method in SPSS software. These five factors are security, performance, internal, time and capacity. To rank those factors we spread questionnaires to 6 IT expert then the data is analyzed using AHP method. The result is that performance factors gained the highest rank from all of the other factors. Thus, consumer can select antivirus software by judging the variables in the performance factors. Those variables are software loading speed, user friendly, no excessive memory use, thorough scanning, and scanning virus fast and accurately.

  13. Metagenomic analysis of bacterial community composition and antibiotic resistance genes in a wastewater treatment plant and its receiving surface water.

    Science.gov (United States)

    Tang, Junying; Bu, Yuanqing; Zhang, Xu-Xiang; Huang, Kailong; He, Xiwei; Ye, Lin; Shan, Zhengjun; Ren, Hongqiang

    2016-10-01

    The presence of pathogenic bacteria and the dissemination of antibiotic resistance genes (ARGs) may pose big risks to the rivers that receive the effluent from municipal wastewater treatment plants (WWTPs). In this study, we investigated the changes of bacterial community and ARGs along treatment processes of one WWTP, and examined the effects of the effluent discharge on the bacterial community and ARGs in the receiving river. Pyrosequencing was applied to reveal bacterial community composition including potential bacterial pathogen, and Illumina high-throughput sequencing was used for profiling ARGs. The results showed that the WWTP had good removal efficiency on potential pathogenic bacteria (especially Arcobacter butzleri) and ARGs. Moreover, the bacterial communities of downstream and upstream of the river showed no significant difference. However, the increase in the abundance of potential pathogens and ARGs at effluent outfall was observed, indicating that WWTP effluent might contribute to the dissemination of potential pathogenic bacteria and ARGs in the receiving river. Copyright © 2016 Elsevier Inc. All rights reserved.

  14. Estimation and analysis of the short-term variations of multi-GNSS receiver differential code biases using global ionosphere maps

    Science.gov (United States)

    Li, Min; Yuan, Yunbin; Wang, Ningbo; Liu, Teng; Chen, Yongchang

    2017-12-01

    Care should be taken to minimize the adverse impact of differential code biases (DCBs) on global navigation satellite systems (GNSS)-derived ionospheric information determinations. For the sake of convenience, satellite and receiver DCB products provided by the International GNSS Service (IGS) are treated as constants over a period of 24 h (Li et al. (2014)). However, if DCB estimates show remarkable intra-day variability, the DCBs estimated as constants over 1-day period will partially account for ionospheric modeling error; in this case DCBs will be required to be estimated over shorter time period. Therefore, it is important to further gain insight into the short-term variation characteristics of receiver DCBs. In this contribution, the IGS combined global ionospheric maps and the German Aerospace Center (DLR)-provided satellite DCBs are used in the improved method to determine the multi-GNSS receiver DCBs with an hourly time resolution. The intra-day stability of the receiver DCBs is thereby analyzed in detail. Based on 1 month of data collected within the multi-GNSS experiment of the IGS, a good agreement within the receiver DCBs is found between the resulting receiver DCB estimates and multi-GNSS DCB products from the DLR at a level of 0.24 ns for GPS, 0.28 ns for GLONASS, 0.28 ns for BDS, and 0.30 ns for Galileo. Although most of the receiver DCBs are relatively stable over a 1-day period, large fluctuations (more than 9 ns between two consecutive hours) within the receiver DCBs can be found. We also demonstrate the impact of the significant short-term variations in receiver DCBs on the extraction of ionospheric total electron content (TEC), at a level of 12.96 TECu (TEC unit). Compared to daily receiver DCB estimates, the hourly DCB estimates obtained from this study can reflect the short-term variations of the DCB estimates more dedicatedly. The main conclusion is that preliminary analysis of characteristics of receiver DCB variations over short

  15. An Investigation of the Relationship between the Fear of Receiving Negative Criticism and of Taking Academic Risk through Canonical Correlation Analysis

    Science.gov (United States)

    Cetin, Bayram; Ilhan, Mustafa; Yilmaz, Ferat

    2014-01-01

    The aim of this study is to examine the relationship between the fear of receiving negative criticism and taking academic risk through canonical correlation analysis-in which a relational model was used. The participants of the study consisted of 215 university students enrolled in various programs at Dicle University's Ziya Gökalp Faculty of…

  16. Evaluation of Deterministic and Complex Analytical Hierarchy Process Methods for Agricultural Land Suitability Analysis in a Changing Climate

    Directory of Open Access Journals (Sweden)

    Harmen Romeijn

    2016-06-01

    Full Text Available Land suitability analysis is employed to evaluate the appropriateness of land for a particular purpose whilst integrating both qualitative and quantitative inputs, which can be continuous in nature. However, in agricultural modelling there is often a disregard of this contiguous aspect. Therefore, some parametric procedures for suitability analysis compartmentalise units into defined membership classes. This imposition of crisp boundaries neglects the continuous formations found throughout nature and overlooks differences and inherent uncertainties found in the modelling. This research will compare two approaches to suitability analysis over three differing methods. The primary approach will use an Analytical Hierarchy Process (AHP, while the other approach will use a Fuzzy AHP over two methods; Fitted Fuzzy AHP and Nested Fuzzy AHP. Secondary to this, each method will be assessed into how it behaves in a climate change scenario to understand and highlight the role of uncertainties in model conceptualisation and structure. Outputs and comparisons between each method, in relation to area, proportion of membership classes and spatial representation, showed that fuzzy modelling techniques detailed a more robust and continuous output. In particular the Nested Fuzzy AHP was concluded to be more pertinent, as it incorporated complex modelling techniques, as well as the initial AHP framework. Through this comparison and assessment of model behaviour, an evaluation of each methods predictive capacity and relevance for decision-making purposes in agricultural applications is gained.

  17. High Spatial Resolution Analysis of Fungal Cell Biochemistry: Bridging the Analytical Gap using Synchrotron FTIR Spectromicroscopy

    International Nuclear Information System (INIS)

    Kaminskyj, S.; Konstantin, J.; Szeghalmi, A.; Gough, K.

    2008-01-01

    Fungi impact humans and the environment in many ways, for good and ill. Some fungi support the growth of terrestrial plants or are used in biotechnology, and yet others are established or emerging pathogens. In some cases, the same organism may play different roles depending on the context or the circumstance. A better understanding of the relationship between fungal biochemical composition as related to the fungal growth environment is essential if we are to support or control their activities. Synchrotron FTIR (sFTIR) spectromicroscopy of fungal hyphae is a major new tool for exploring cell composition at a high spatial resolution. Brilliant synchrotron light is essential for this analysis due to the small size of fungal hyphae. sFTIR biochemical characterization of subcellular variation in hyphal composition will allow detailed exploration of fungal responses to experimental treatments and to environmental factors.

  18. Interventions to reduce sexual prejudice: a study-space analysis and meta-analytic review.

    Science.gov (United States)

    Bartoş, Sebastian E; Berger, Israel; Hegarty, Peter

    2014-01-01

    Sexual prejudice is an important threat to the physical and mental well-being of lesbians, gay men, and bisexual people. Therefore, we reviewed the effectiveness of interventions designed to reduce such prejudice. A study-space analysis was performed on published and unpublished papers from all over the world to identify well-studied and underexplored issues. Most studies were conducted with North American undergraduates and were educational in nature. Dissertations were often innovative and well designed but were rarely published. We then performed meta-analyses on sets of comparable studies. Education, contact with gay people, and combining contact with education had a medium-size effect on several measures of sexual prejudice. The manipulation of social norms was effective in reducing antigay behavior. Other promising interventions, such as the use of entertainment media to promote tolerance, need further investigation. More research is also needed on populations other than American students, particularly groups who may have higher levels of sexual prejudice.

  19. Analytical analysis of soil-moisture and trace-contaminant transport

    International Nuclear Information System (INIS)

    Larson, N.M.; Reeves, M.

    1976-03-01

    A transport model is presented which predicts the coupled movement of both water and trace contaminants through a layered and unsaturated soil-moisture zone. In order to achieve computation speeds suitable for watershed implementations, moisture properties are approximated as exponential functions of pressure head, and lateral flows are treated as sinks in a basically vertical one-dimensional analysis. In addition, only advection by the Darcy-flow velocities and linear adsorption by the soil matrix are considered in depicting movement of the trace contaminant. Formal solution of the resulting transport equations is obtained through use of both eigenfunction-expansion and coordinate-transformation methods. Numerical solution is effected by means of a program written in FORTRAN IV and implemented on an IBM 360/91 computer. Two example calculations illustrate both strengths and weaknesses of our model

  20. Mineral elements in dental composites by atomic and nuclear analytical methods. II. Improved analysis by PIXE

    International Nuclear Information System (INIS)

    Preoteasa, E.A.; Ciortea, C.; Fluerasu, D.; Enescu, S.E.; Preoteasa, Elena

    2000-01-01

    In the corrosive environment of the mouth, a diversity of interactions take place at the solid-solid and solid-liquid interfaces of a tooth's filling. Moreover, the mineral elements of the restorative material may induce a complex response of the organism. The approach of these problems requires sensitive surface elemental analysis of the composite and of the dental enamel and dentine. Particle-induced X-ray emission (PIXE) is such a method and has been applied in investigations of hard dental tissues; however, it was not used so far in the study of dental composites. We continue our study by evaluating the potential of PIXE for analysis of these materials. Three types of composites with two color shades each have been studied. The measurements were performed with 3 MeV protons, using a hyperpure Ge detector in a spectroscopic chain connected to a computer. The spectra were processed with the dedicated program Leone. PIXE without additional Al absorbent foil allowed the detection of Z > 14 elements in composites. In two glass- and ceramics-based materials we found: Ca, Zr, Ba, Yb and traces of Sr and In in Tetric Ceram (Vivadent); and Ca, Zr, Ba, Hf, possibly Mn, and traces of Ni, Ho, Ti, Fe, Cr in Valux Plus (3M Dental), after elimination of the escape peaks. In quartz-based Evicrol (Spofa), Si, Ca, Ti, Fe and traces of K, Cr, Ni, Cu, Zn were seen. Materials with different color shades showed variations of Ti, Cr, Fe, Ni and Cu in Evicrol, as contrasted to Tetric Ceram and Valux Plus whose spectra were color-invariant. By its sensitivity and low background, PIXE enables the detection of many trace elements in dental composites; it could serve also in new materials' development and forensic expertise. (authors)

  1. Applied behavior analytic intervention for autism in early childhood: meta-analysis, meta-regression and dose-response meta-analysis of multiple outcomes.

    Science.gov (United States)

    Virués-Ortega, Javier

    2010-06-01

    A number of clinical trials and single-subject studies have been published measuring the effectiveness of long-term, comprehensive applied behavior analytic (ABA) intervention for young children with autism. However, the overall appreciation of this literature through standardized measures has been hampered by the varying methods, designs, treatment features and quality standards of published studies. In an attempt to fill this gap in the literature, state-of-the-art meta-analytical methods were implemented, including quality assessment, sensitivity analysis, meta-regression, dose-response meta-analysis and meta-analysis of studies of different metrics. Results suggested that long-term, comprehensive ABA intervention leads to (positive) medium to large effects in terms of intellectual functioning, language development, acquisition of daily living skills and social functioning in children with autism. Although favorable effects were apparent across all outcomes, language-related outcomes (IQ, receptive and expressive language, communication) were superior to non-verbal IQ, social functioning and daily living skills, with effect sizes approaching 1.5 for receptive and expressive language and communication skills. Dose-dependant effect sizes were apparent by levels of total treatment hours for language and adaptation composite scores. Methodological issues relating ABA clinical trials for autism are discussed.

  2. [Analytical procedure of variable number of tandem repeats (VNTR) analysis and effective use of analysis results for tuberculosis control].

    Science.gov (United States)

    Hachisu, Yushi; Hashimoto, Ruiko; Kishida, Kazunori; Yokoyama, Eiji

    2013-12-01

    Variable number of tandem repeats (VNTR) analysis is one of the methods for molecular epidemiological studies of Mycobacterium tuberculosis. VNTR analysis is a method based on PCR, provides rapid highly reproducible results and higher strain discrimination power than the restriction fragment length polymorphism (RFLP) analysis widely used in molecular epidemiological studies of Mycobacterium tuberculosis. Genetic lineage compositions of Mycobacterium tuberculosis clinical isolates differ among the regions from where they are isolated, and allelic diversity at each locus also differs among the genetic lineages of Mycobacterium tuberculosis. Therefore, the combination of VNTR loci that can provide high discrimination capacity for analysis is not common in every region. The Japan Anti-Tuberculosis Association (JATA) 12 (15) reported a standard combination of VNTR loci for analysis in Japan, and the combination with hypervariable (HV) loci added to JATA12 (15), which has very high discrimination capacity, was also reported. From these reports, it is thought that data sharing between institutions and construction of a nationwide database will progress from now on. Using database construction of VNTR profiles, VNTR analysis has become an effective tool to trace the route of tuberculosis infection, and also helps in decision-making in the treatment course. However, in order to utilize the results of VNTR analysis effectively, it is important that each related organization cooperates closely, and analysis should be appropriately applied in the system in which accurate control and private information protection are ensured.

  3. Aroma analysis and quality control of food using highly sensitive analytical methods

    International Nuclear Information System (INIS)

    Mayr, D.

    2003-02-01

    This thesis deals with the development of quality control methods for food based on headspace measurements by Proton-Transfer-Reaction Mass-Spectrometry (PTR-MS) and with aroma analysis of food using PTR-MS and Gas Chromatography-Olfactometry (GC-O). An objective method was developed for the determination of a herb extract's quality; this quality was checked by a sensory analysis until now. The concentrations of the volatile organic compounds (VOCs) in the headspace of 81 different batches were measured by PTR-MS. Based on the sensory judgment of the customer, characteristic differences in the emissions of 'good' and 'bad' quality samples were identified and a method for the quality control of this herb extract was developed. This novel method enables the producing company to check and ensure that they are only selling high-quality products and therefore avoid complaints of the customer. Furthermore this method can be used for controlling, optimizing and automating the production process. VOCs emitted by meat were investigated using PTR-MS to develop a rapid, non-destructive and quantitative technique for determination of the microbial contamination of meat. Meat samples (beef, pork and poultry) that were wrapped into different kinds of packages (air and vacuum) were stored in at 4 o C for up to 13 days. The emitted VOCs were measured as a function of storage time and identified partly. The concentration of many of the measured VOCs, e.g. sulfur compounds like methanethiol, dimethylsulfide and dimethyldisulfide, largely increased over the storage time. There were big differences in the emissions of normal air- and vacuum-packed meat. VOCs typically emitted by air-packaged meat were methanethiol, dimethylsulfide and dimethyldisulfide, while ethanol and methanol were found in vacuum-packaged meat. A comparison of the PTR-MS results with those obtained by a bacteriological examination performed at the same time showed strong correlations (up to 99 %) between the

  4. Mechanisms and mediation in survival analysis: towards an integrated analytical framework.

    Science.gov (United States)

    Pratschke, Jonathan; Haase, Trutz; Comber, Harry; Sharp, Linda; de Camargo Cancela, Marianna; Johnson, Howard

    2016-02-29

    A wide-ranging debate has taken place in recent years on mediation analysis and causal modelling, raising profound theoretical, philosophical and methodological questions. The authors build on the results of these discussions to work towards an integrated approach to the analysis of research questions that situate survival outcomes in relation to complex causal pathways with multiple mediators. The background to this contribution is the increasingly urgent need for policy-relevant research on the nature of inequalities in health and healthcare. The authors begin by summarising debates on causal inference, mediated effects and statistical models, showing that these three strands of research have powerful synergies. They review a range of approaches which seek to extend existing survival models to obtain valid estimates of mediation effects. They then argue for an alternative strategy, which involves integrating survival outcomes within Structural Equation Models via the discrete-time survival model. This approach can provide an integrated framework for studying mediation effects in relation to survival outcomes, an issue of great relevance in applied health research. The authors provide an example of how these techniques can be used to explore whether the social class position of patients has a significant indirect effect on the hazard of death from colon cancer. The results suggest that the indirect effects of social class on survival are substantial and negative (-0.23 overall). In addition to the substantial direct effect of this variable (-0.60), its indirect effects account for more than one quarter of the total effect. The two main pathways for this indirect effect, via emergency admission (-0.12), on the one hand, and hospital caseload, on the other, (-0.10) are of similar size. The discrete-time survival model provides an attractive way of integrating time-to-event data within the field of Structural Equation Modelling. The authors demonstrate the efficacy

  5. Radionuclide migration through fractured rock for arbitrary-length decay chain: Analytical solution and global sensitivity analysis

    Science.gov (United States)

    Shahkarami, Pirouz; Liu, Longcheng; Moreno, Luis; Neretnieks, Ivars

    2015-01-01

    This study presents an analytical approach to simulate nuclide migration through a channel in a fracture accounting for an arbitrary-length decay chain. The nuclides are retarded as they diffuse in the porous rock matrix and stagnant zones in the fracture. The Laplace transform and similarity transform techniques are applied to solve the model. The analytical solution to the nuclide concentrations at the fracture outlet is governed by nine parameters representing different mechanisms acting on nuclide transport through a fracture, including diffusion into the rock matrices, diffusion into the stagnant water zone, chain decay and hydrodynamic dispersion. Furthermore, to assess how sensitive the results are to parameter uncertainties, the Sobol method is applied in variance-based global sensitivity analyses of the model output. The Sobol indices show how uncertainty in the model output is apportioned to the uncertainty in the model input. This method takes into account both direct effects and interaction effects between input parameters. The simulation results suggest that in the case of pulse injections, ignoring the effect of a stagnant water zone can lead to significant errors in the time of first arrival and the peak value of the nuclides. Likewise, neglecting the parent and modeling its daughter as a single stable species can result in a significant overestimation of the peak value of the daughter nuclide. It is also found that as the dispersion increases, the early arrival time and the peak time of the daughter decrease while the peak value increases. More importantly, the global sensitivity analysis reveals that for time periods greater than a few thousand years, the uncertainty of the model output is more sensitive to the values of the individual parameters than to the interaction between them. Moreover, if one tries to evaluate the true values of the input parameters at the same cost and effort, the determination of priorities should follow a certain

  6. NMR spectroscopic and analytical ultracentrifuge analysis of membrane protein detergent complexes

    Directory of Open Access Journals (Sweden)

    Choe Senyon

    2007-11-01

    Full Text Available Abstract Background Structural studies of integral membrane proteins (IMPs are hampered by inherent difficulties in their heterologous expression and in the purification of solubilized protein-detergent complexes (PDCs. The choice and concentrations of detergents used in an IMP preparation play a critical role in protein homogeneity and are thus important for successful crystallization. Results Seeking an effective and standardized means applicable to genomic approaches for the characterization of PDCs, we chose 1D-NMR spectroscopic analysis to monitor the detergent content throughout their purification: protein extraction, detergent exchange, and sample concentration. We demonstrate that a single NMR measurement combined with a SDS-PAGE of a detergent extracted sample provides a useful gauge of the detergent's extraction potential for a given protein. Furthermore, careful monitoring of the detergent content during the process of IMP production allows for a high level of reproducibility. We also show that in many cases a simple sedimentation velocity measurement provides sufficient data to estimate both the oligomeric state and the detergent-to-protein ratio in PDCs, as well as to evaluate the homogeneity of the samples prior to crystallization screening. Conclusion The techniques presented here facilitate the screening and selection of the extraction detergent, as well as help to maintain reproducibility in the detergent exchange and PDC concentration procedures. Such reproducibility is particularly important for the optimization of initial crystallization conditions, for which multiple purifications are routinely required.

  7. Mode analysis for a microwave driven plasma discharge: A comparison between analytical and numerical results

    Science.gov (United States)

    Szeremley, Daniel; Mussenbrock, Thomas; Brinkmann, Ralf Peter; Zimmermanns, Marc; Rolfes, Ilona; Eremin, Denis; Ruhr-University Bochum, Theoretical Electrical Engineering Team; Ruhr-University Bochum, Institute of Microwave Systems Team

    2015-09-01

    The market shows in recent years a growing demand for bottles made of polyethylene terephthalate (PET). Therefore, fast and efficient sterilization processes as well as barrier coatings to decrease gas permeation are required. A specialized microwave plasma source - referred to as the plasmaline - has been developed to allow for depositing thin films of e.g. silicon oxid on the inner surface of such PET bottles. The plasmaline is a coaxial waveguide combined with a gas-inlet which is inserted into the empty bottle and initiates a reactive plasma. To optimize and control the different surface processes, it is essential to fully understand the microwave power coupling to the plasma and the related heating of electrons inside the bottle and thus the electromagnetic wave propagation along the plasmaline. In this contribution, we present a detailed dispersion analysis based on a numerical approach. We study how modes of guided waves are propagating under different conditions, if at all. The authors gratefully acknowledge the financial support of the German Research Foundation (DFG) within the framework of the collaborative research centre TRR87.

  8. Application of novel analytical ultracentrifuge analysis to solutions of fungal mannans

    KAUST Repository

    Gillis, Richard B.

    2016-07-21

    Polysaccharides, the most abundant biopolymers, are required for a host of activities in lower organisms, animals, and plants. Their solution characterization is challenging due to their complex shape, heterogeneity, and size. Here, recently developed data analysis approaches were applied for traditional sedimentation equilibrium and velocity methods in order to investigate the molar mass distribution(s) of a subtype of polysaccharide, namely, mannans from four Candida spp. The molecular weight distributions of these mannans were studied using two recently developed equilibrium approaches: SEDFIT-MSTAR and MULTISIG, resulting in corroboratory distribution profiles. Additionally, sedimentation velocity data for all four mannans, analyzed using ls-g*(s) and Extended Fujita approaches, suggest that two of the fungal mannans (FM-1 and FM-3) have a unimodal distribution of molecular species whereas two others (FM-2 and FM-4) displayed bi-modal and broad distributions, respectively: this demonstrates considerable molecular heterogeneity in these polysaccharides, consistent with previous observations of mannans and polysaccharides in general. These methods not only have applications for the characterization of mannans but for other biopolymers such as polysaccharides, DNA, and proteins (including intrinsically disordered proteins).

  9. Analytical development of disturbed matrix eigenvalue problem applied to mixed convection stability analysis in Darcy media

    Science.gov (United States)

    Hamed, Haikel Ben; Bennacer, Rachid

    2008-08-01

    This work consists in evaluating algebraically and numerically the influence of a disturbance on the spectral values of a diagonalizable matrix. Thus, two approaches will be possible; to use the theorem of disturbances of a matrix depending on a parameter, due to Lidskii and primarily based on the structure of Jordan of the no disturbed matrix. The second approach consists in factorizing the matrix system, and then carrying out a numerical calculation of the roots of the disturbances matrix characteristic polynomial. This problem can be a standard model in the equations of the continuous media mechanics. During this work, we chose to use the second approach and in order to illustrate the application, we choose the Rayleigh-Bénard problem in Darcy media, disturbed by a filtering through flow. The matrix form of the problem is calculated starting from a linear stability analysis by a finite elements method. We show that it is possible to break up the general phenomenon into other elementary ones described respectively by a disturbed matrix and a disturbance. A good agreement between the two methods was seen. To cite this article: H.B. Hamed, R. Bennacer, C. R. Mecanique 336 (2008).

  10. Improved analytical methods for microarray-based genome-composition analysis.

    Science.gov (United States)

    Kim, Charles C; Joyce, Elizabeth A; Chan, Kaman; Falkow, Stanley

    2002-10-29

    Whereas genome sequencing has given us high-resolution pictures of many different species of bacteria, microarrays provide a means of obtaining information on genome composition for many strains of a given species. Genome-composition analysis using microarrays, or 'genomotyping', can be used to categorize genes into 'present' and 'divergent' categories based on the level of hybridization signal. This typically involves selecting a signal value that is used as a cutoff to discriminate present (high signal) and divergent (low signal) genes. Current methodology uses empirical determination of cutoffs for classification into these categories, but this methodology is subject to several problems that can result in the misclassification of many genes. We describe a method that depends on the shape of the signal-ratio distribution and does not require empirical determination of a cutoff. Moreover, the cutoff is determined on an array-to-array basis, accounting for variation in strain composition and hybridization quality. The algorithm also provides an estimate of the probability that any given gene is present, which provides a measure of confidence in the categorical assignments. Many genes previously classified as present using static methods are in fact divergent on the basis of microarray signal; this is corrected by our algorithm. We have reassigned hundreds of genes from previous genomotyping studies of Helicobacter pylori and Campylobacter jejuni strains, and expect that the algorithm should be widely applicable to genomotyping data.

  11. The body in analysis: authentic movement and witnessing in analytic practice.

    Science.gov (United States)

    Wyman-McGinty, W

    1998-04-01

    This paper will describe a form of active imagination called authentic movement, in which attention is given to the somatic unconscious. In authentic movement, patients are encouraged to focus inward and attend to any bodily sensations, images and feelings which may arise. In the process of focusing inward on one's bodily-felt experience, images, somatic memory and the accompanying feelings which arise are then available to be explored as a communication from the patient's unconscious. Authentic movement supports the individual in linking image with affect in that the individual re-experiences the somatic aspect of symbolization. What was previously conserved on the somatic level as unmentalized experience, can now begin to be taken up into the mind, thought about, and made available for analysis. In authentic movement, the analyst acts as a silent witness to the patient's explorations. The quiet focused attention of the witness helps to create a secure containing environment in which the person moving can experience a sense of feeling held and seen. The function of the witness is to hold the patient's experience in his own mind, particularly what is not yet mentalized. The witness utilizes his somatic countertransference, including any images, feelings and bodily responses which are generated by what is being communicated non-verbally, as a means of understanding and responding to the patient's material.

  12. Nuclear analytical chemistry

    International Nuclear Information System (INIS)

    Brune, D.; Forkman, B.; Persson, B.

    1984-01-01

    This book covers the general theories and techniques of nuclear chemical analysis, directed at applications in analytical chemistry, nuclear medicine, radiophysics, agriculture, environmental sciences, geological exploration, industrial process control, etc. The main principles of nuclear physics and nuclear detection on which the analysis is based are briefly outlined. An attempt is made to emphasise the fundamentals of activation analysis, detection and activation methods, as well as their applications. The book provides guidance in analytical chemistry, agriculture, environmental and biomedical sciences, etc. The contents include: the nuclear periodic system; nuclear decay; nuclear reactions; nuclear radiation sources; interaction of radiation with matter; principles of radiation detectors; nuclear electronics; statistical methods and spectral analysis; methods of radiation detection; neutron activation analysis; charged particle activation analysis; photon activation analysis; sample preparation and chemical separation; nuclear chemical analysis in biological and medical research; the use of nuclear chemical analysis in the field of criminology; nuclear chemical analysis in environmental sciences, geology and mineral exploration; and radiation protection

  13. The Thirty Gigahertz Instrument Receiver for the QUIJOTE Experiment: Preliminary Polarization Measurements and Systematic-Error Analysis.

    Science.gov (United States)

    Casas, Francisco J; Ortiz, David; Villa, Enrique; Cano, Juan L; Cagigas, Jaime; Pérez, Ana R; Aja, Beatriz; Terán, J Vicente; de la Fuente, Luisa; Artal, Eduardo; Hoyland, Roger; Génova-Santos, Ricardo

    2015-08-05

    This paper presents preliminary polarization measurements and systematic-error characterization of the Thirty Gigahertz Instrument receiver developed for the QUIJOTE experiment. The instrument has been designed to measure the polarization of Cosmic Microwave Background radiation from the sky, obtaining the Q, U, and I Stokes parameters of the incoming signal simultaneously. Two kinds of linearly polarized input signals have been used as excitations in the polarimeter measurement tests in the laboratory; these show consistent results in terms of the Stokes parameters obtained. A measurement-based systematic-error characterization technique has been used in order to determine the possible sources of instrumental errors and to assist in the polarimeter calibration process.

  14. UNDEUTSCH HYPOTHESIS AND CRITERIA BASED CONTENT ANALYSIS: A META-ANALYTIC REVIEW

    Directory of Open Access Journals (Sweden)

    Bárbara G. Amado

    2015-01-01

    Full Text Available The credibility of a testimony is a crucial component of judicial decision-making. Checklists of testimony credibility criteria are extensively used by forensic psychologists to assess the credibility of a testimony, and in many countries they are admitted as valid scientific evidence in a court of law. These checklists are based on the Undeutsch hypothesis asserting that statements derived from the memory of real-life experiences differ significantly in content and quality from fabricated or fictitious accounts. Notwithstanding, there is considerable controversy regarding the degree to which these checklists comply with the legal standards for scientific evidence to be admitted in a court of law (e.g., Daubert standards. In several countries, these checklists are not admitted as valid evidence in court, particularly in view of the inconsistent results reported in the scientific literature. Bearing in mind these issues, a meta-analysis was designed to test the Undeutsch hypothesis using the CBCA Checklist of criteria to discern between memories of self-experienced real-life events and fabricated or fictitious accounts. As the original hypothesis was formulated for populations of children, only quantitative studies with samples of children were considered for this study. In line with the Undeutsch hypothesis, the results showed a significant positive effect size that is generalizable to the total CBCA score, δ = 0.79. Moreover, a significant positive effect size was observed in each and all of the credibility criteria. In conclusion, the results corroborated the validity of the Undeutsch hypothesis and the CBCA criteria for discriminating between the memory of real self-experienced events and false or invented accounts. The results are discussed in terms of the implications for forensic practice. Con frecuencia, la evaluación de la fiabilidad de un testimonio se lleva a cabo mediante el uso de sistemas categoriales de análisis de contenido

  15. Calculation and analysis of thermal impedance of microelectronic structures from analytical models

    Science.gov (United States)

    Vintrou, S.; Laraqi, N.; Baïri, A.

    2012-01-01

    This article deals with thermal impedances of microelectronic components that are useful in Simulation Programs with Integrated Circuit Emphasis (SPICE). In devices like heterojunction bipolar transistors, the active regions thicknesses are often much smaller than the substrates thicknesses. The devices can then be thermally assimilated to heat densities located on top of solid media. In addition to that, when the other dimensions of the heat sources are also much smaller than the substrates dimensions, it is reasonable to consider that the substrate is semi-infinite. First, the expression of the thermal impedance Z of a circular shape heat source centered on top of a half space is presented. For this purpose, the integral transform technique has been used to solve the tri-dimensional heat conduction equation in the frequency domain. The original expression is explicit, exact and allows obtaining results very quickly. After that, the case of a circular heat source on top of a cylinder is treated. A complete analysis of the substrate dimensions influence on the thermal impedance is done. It is based on the impedance decomposition into the one-dimensional impedance and the spreading impedance. By comparing these impedances with that obtained for the heat source on top of the semi-infinite medium, the threshold pulsation at which the thermal impedance of the finite medium differs from the thermal impedance of the half space is extracted. Moreover the geometrical criteria resulting in an error of less than 2% between the spreading impedance of the finite medium and the semi-infinite one are extracted. When these criteria are observed the impedance can be calculated using two perfectly known impedances: the spreading impedance of the semi-infinite medium and the one-dimensional impedance. The results are plotted on the Nyquist diagram, providing a compact representation. Finally the assumption of a circular shape heat source to approximate the thermal impedance of a

  16. Analytical techniques for boron and boron 10 analysis in a solid experimental tumor EO.771

    International Nuclear Information System (INIS)

    Porschen, W.; Marx, J.; Feinendegen, L.E.

    1987-01-01

    If a tumor can be preferentially loaded with a suitable boron-10 compound and irradiated with thermal neutrons, malignant cells can be selectively destroyed via the α-particle + Li 7-nucleus from the reaction 10 B(n,α) 7 Li. Neutron capture therapy with two boron-10 amino acid analogs of low toxicity has been tested in recent years: (a) trimethylamine carboxyborane, (A3) and (b) amine-carboxyborane, (A7). Now the boron-10 glycineamide analog (A8), amineboryl carboxamide has been synthsized; it contains 13.81% boron (90% Boron 10+10% Boron 11) and shows a very low toxicity in mice. The effects of this compund were tested on the syngeneic solid adenocarcinoma EO 771 on the right hind leg of male C57 BL/6J mice under standard conditions, by measuring tumor volume growth delay and cell cycle changes using flow cytometry. Boron distribution between tumor and muscle was analyzed by emission spectroscopy with inductively coupled plasma (ICP) following injection of a suspension of peanut oil emulsion. In addition, boron-10 concentration in the tumor were analyzed with prompt γ-activation analysis and neutron capture radiography (Kodak-Pathe LR115) at the MRR reactor in Brookhaven after i.p. injection of 0.4 mg/g A8. Application of A8 alone (0.4 mg/g i.p.) or thermal neutron irradiation of the tumor EO. 771 produced a tumor growth delay of 1-2 days for tumor volume doubling. Application of the boron 10 glycine-amide analog A8 i.p. plus 5x10 12 n/cm 2 resulted in a growth delay of 3-6 days. In contrast intratumoral application of A8 plus 4x10 12 n/cm 2 neutrons gave a growth delay of 7-14 days; the fraction of (G2+M) cells rose from 35% (neutrons alone) to 52%, as evaluated from flow cytometry. (orig.)

  17. Hepatitis B reactivation in HBsAg-negative/HBcAb-positive patients receiving immunosuppressive therapy for glomerulonephritis: a retrospective analysis.

    Science.gov (United States)

    Fang, Jing; Li, Wenge; Peng, Xiangxin; Tan, Zhao; Tan, Min; Zhang, Cong; Wang, Wenbo; Xu, Zhihong; Zhou, Gumin

    2017-03-01

    The aim of this study is to investigate the prevalence and risk factors for hepatitis B virus (HBV) reactivation in HBsAg-negative/HBcAb-positive patients receiving immunosuppressive therapy for glomerulonephritis. We performed a retrospective study of 745 HBsAg-negative/HBcAb-positive patients undergoing immunosuppressive therapy for glomerulonephritis from years 2003 to 2012 at the department of nephrology, China-Japan Friendship Hospital, Beijing, China. The patients were divided into HBV reactivation group (n = 27) and non-HBV reactivation group (n = 718). The prevalence of HBV reactivation in patients receiving immunosuppressive therapy for glomerulonephritis was up to 3.62% in serological status of HBsAg-negative/HBcAb-positive. HBV reactivation was associated with several findings: greater proportion of lupus nephritis (25.93 vs. 9.61%, p = 0.014), much higher percentage of HBsAb-negative (74.07 vs. 23.82%, p HBcAb-positive glomerulonephritis patients treated with immunosuppressant, and the prevalence was up to 3.62%. Patients with serological status of HBsAb-negative, more than 1 year of immunosuppressive therapy, and combined immunosuppressant are independent risk factors for HBV reactivation.

  18. Analytical quadrics

    CERN Document Server

    Spain, Barry; Ulam, S; Stark, M

    1960-01-01

    Analytical Quadrics focuses on the analytical geometry of three dimensions. The book first discusses the theory of the plane, sphere, cone, cylinder, straight line, and central quadrics in their standard forms. The idea of the plane at infinity is introduced through the homogenous Cartesian coordinates and applied to the nature of the intersection of three planes and to the circular sections of quadrics. The text also focuses on paraboloid, including polar properties, center of a section, axes of plane section, and generators of hyperbolic paraboloid. The book also touches on homogenous coordi

  19. A primer on receiver operating characteristic analysis and diagnostic efficiency statistics for pediatric psychology: we are ready to ROC.

    Science.gov (United States)

    Youngstrom, Eric A

    2014-03-01

    To offer a practical demonstration of receiver operating characteristic (ROC) analyses, diagnostic efficiency statistics, and their application to clinical decision making using a popular parent checklist to assess for potential mood disorder. Secondary analyses of data from 589 families seeking outpatient mental health services, completing the Child Behavior Checklist and semi-structured diagnostic interviews. Internalizing Problems raw scores discriminated mood disorders significantly better than did age- and gender-normed T scores, or an Affective Problems score. Internalizing scores 30 had a diagnostic likelihood ratio of 7.4. This study illustrates a series of steps in defining a clinical problem, operationalizing it, selecting a valid study design, and using ROC analyses to generate statistics that support clinical decisions. The ROC framework offers important advantages for clinical interpretation. Appendices include sample scripts using SPSS and R to check assumptions and conduct ROC analyses.

  20. The Thirty Gigahertz Instrument Receiver for the QUIJOTE Experiment: Preliminary Polarization Measurements and Systematic-Error Analysis

    Directory of Open Access Journals (Sweden)

    Francisco J. Casas

    2015-08-01

    Full Text Available This paper presents preliminary polarization measurements and systematic-error characterization of the Thirty Gigahertz Instrument receiver developed for the QUIJOTE experiment. The instrument has been designed to measure the polarization of Cosmic Microwave Background radiation from the sky, obtaining the Q, U, and I Stokes parameters of the incoming signal simultaneously. Two kinds of linearly polarized input signals have been used as excitations in the polarimeter measurement tests in the laboratory; these show consistent results in terms of the Stokes parameters obtained. A measurement-based systematic-error characterization technique has been used in order to determine the possible sources of instrumental errors and to assist in the polarimeter calibration process.