WorldWideScience

Sample records for analysis supports conservation

  1. Development of Decision Support Process for Building Energy Conservation Measures and Economic Analysis

    Directory of Open Access Journals (Sweden)

    Bo-Eun Choi

    2017-03-01

    Full Text Available As policies for energy efficiency of buildings are being actively implemented, building energy performance improvement is urgently required. However, in Korea, information on measures and technologies for building energy efficiency is dispersed and concrete methods are not established, making it difficult to apply effective measures. Therefore, it is required to apply and evaluate energy efficiency measures through database construction integrating diverse information. In this study, the energy efficiency measures in the architectural sector that satisfy domestic legal standards are built. Because of the economic evaluation is necessary for the constructed alternatives, an economic efficiency database was established. The target building was set up, and energy efficiency measures were derived. In addition, a methodology that can induce energy efficient decision making of buildings was proposed, and the energy use evaluation and the economic analysis for each of the alternatives derived from applying the methodology to the target building were carried out. Furthermore, the optimal energy efficiency measures for the target building were suggested through the application of the decision-making process.

  2. Data Acquisition, Management, and Analysis in Support of the Audiology and Hearing Conservation and the Orbital Debris Program Office

    Science.gov (United States)

    Dicken, Todd

    2012-01-01

    My internship at Johnson Space Center, Houston TX comprised of working simultaneously in the Space Life Science Directorate (Clinical Services Branch, SD3) in Audiology and Hearing Conservation and in the Astromaterials Research and Exploration Sciences Directorate in the Orbital Debris Program Office (KX). The purpose of the project done to support the Audiology and Hearing Conservation Clinic (AuHCon) is to organize and analyze auditory test data that has been obtained from tests conducted onboard the International Space Station (ISS) and in Johnson Space Center's clinic. Astronauts undergo a special type of auditory test called an On-Orbit Hearing Assessment (OOHA), which monitors hearing function while crewmembers are exposed to noise and microgravity during long-duration spaceflight. Data needed to be formatted to assist the Audiologist in studying, analyzing and reporting OOHA results from all ISS missions, with comparison to conventional preflight and post-flight audiometric test results of crewmembers. Orbital debris is the #1 threat to manned spacecraft; therefore NASA is investing in different measurement techniques to acquire information on orbital debris. These measurements are taken with telescopes in different parts of the world to acquire brightness variations over time, from which size, rotation rates and material information can be determined for orbital debris. Currently many assumptions are taken to resolve size and material from observed brightness, therefore a laboratory (Optical Measurement Center) is used to simulate the space environment and acquire information of known targets suited to best model the orbital debris population. In the Orbital Debris Program Office (ODPO) telescopic data were acquired and analyzed to better assess the orbital debris population.

  3. Bi-Temporal Analysis of High-Resolution Satellite Imagery in Support of a Forest Conservation Program in Western Uganda

    Science.gov (United States)

    Thomas, N.; Lambin, E.; Audy, R.; Biryahwaho, B.; de Laat, J.; Jayachandran, S.

    2014-12-01

    Recent studies in land use sustainability have shown the conservation value of even small forest fragments in tropical smallholder agricultural regions. Forest patches provide important ecosystem services, wildlife habitat, and support human livelihoods. Our study incorporates multiple dates of high-resolution Quickbird imagery to map forest disturbance and regrowth in a smallholder agricultural landscape in western Uganda. This work is in support of a payments for ecosystem services (PES) project which uses a randomized controlled trial to assess the efficacy of PES for enhancing forest conservation. The research presented here details the remote sensing phase of this project. We developed an object-based methodology for detecting forest change from high-resolution imagery that calculates per class image reflectance and change statistics to determine persistent forest, non-forest, forest gain, and forest loss classes. The large study area (~ 2,400 km2) necessitated using a combination of 10 different image pairs of varying seasonality, sun angle, and viewing angle. We discuss the impact of these factors on mapping results. Reflectance data was used in conjunction with texture measures and knowledge-driven modeling to derive forest change maps. First, baseline Quickbird images were mapped into tree cover and non-tree categories based on segmented image objects and field inventory data, applied through a classification and regression tree (CART) classifier. Then a bi-temporal segmentation layer was generated and a series of object metrics from both image dates were extracted. A sample set of persistent forest objects that remained undisturbed was derived from the tree cover map and the red band (B3) change values. We calculated a variety of statistical indices for these persistent tree cover objects from the post- survey imagery to create maps of both forest cover loss and forest cover gain. These results are compared to visually assessed image objects in addition

  4. Technical support document: Energy conservation standards for consumer products: Dishwashers, clothes washers, and clothes dryers including: Environmental impacts; regulatory impact analysis

    Energy Technology Data Exchange (ETDEWEB)

    1990-12-01

    The Energy Policy and Conservation Act as amended (P.L. 94-163), establishes energy conservation standards for 12 of the 13 types of consumer products specifically covered by the Act. The legislation requires the Department of Energy (DOE) to consider new or amended standards for these and other types of products at specified times. This Technical Support Document presents the methodology, data and results from the analysis of the energy and economic impacts of standards on dishwashers, clothes washers, and clothes dryers. The economic impact analysis is performed in five major areas: An Engineering Analysis, which establishes technical feasibility and product attributes including costs of design options to improve appliance efficiency. A Consumer Analysis at two levels: national aggregate impacts, and impacts on individuals. The national aggregate impacts include forecasts of appliance sales, efficiencies, energy use, and consumer expenditures. The individual impacts are analyzed by Life-Cycle Cost (LCC), Payback Periods, and Cost of Conserved Energy (CCE), which evaluate the savings in operating expenses relative to increases in purchase price; A Manufacturer Analysis, which provides an estimate of manufacturers' response to the proposed standards. Their response is quantified by changes in several measures of financial performance for a firm. An Industry Impact Analysis shows financial and competitive impacts on the appliance industry. A Utility Analysis that measures the impacts of the altered energy-consumption patterns on electric utilities. A Environmental Effects analysis, which estimates changes in emissions of carbon dioxide, sulfur oxides, and nitrogen oxides, due to reduced energy consumption in the home and at the power plant. A Regulatory Impact Analysis collects the results of all the analyses into the net benefits and costs from a national perspective. 47 figs., 171 tabs. (JF)

  5. Economic analysis in support of proposed interim energy conservation voluntary performance standards for new non-federal residential buildings: Volume 6

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1989-09-01

    The objective of this document is to present an analysis of the impacts of the proposed voluntary energy conservation standard fr the construction of new residential buildings. This analysis examines the impacts of having the proposed residential standard apply immediately and, alternatively, having the proposed standard phased in over a five-year period.

  6. Namibia - Conservancy Support and Indigenous Natural Products

    Data.gov (United States)

    Millennium Challenge Corporation — The eval­u­ation employs a mixed-methods approach in which qual­itative techniques and quan­ti­ta­tive ana­lysis support each other, recognizing that the techniques...

  7. Analysis of self-similar solutions of multidimensional conservation laws

    Energy Technology Data Exchange (ETDEWEB)

    Keyfitz, Barbara

    2014-02-15

    This project focused on analysis of multidimensional conservation laws, specifically on extensions to the study of self-siminar solutions, a project initiated by the PI. In addition, progress was made on an approach to studying conservation laws of very low regularity; in this research, the context was a novel problem in chromatography. Two graduate students in mathematics were supported during the grant period, and have almost completed their thesis research.

  8. DNA sequence analysis of conserved and unique regions of swinepox virus: identification of genetic elements supporting phenotypic observations including a novel G protein-coupled receptor homologue.

    Science.gov (United States)

    Massung, R F; Jayarama, V; Moyer, R W

    1993-12-01

    Swinepox virus (SPV) contains a double-stranded cross-linked linear DNA genome of approximately 175 kilobase pairs with terminal inverted repetitions (TIRs) of 4.3 kb. The nucleotide sequence was determined for fragments from several regions of the genome including a 2.85-kb fragment from the central potentially conserved portion and two fragments within the presumed variable near-terminal regions which tend to be unique to a given poxvirus. The core sequence contains one partial and two complete open reading frames that are highly conserved and colinear with three contiguous ORFs within the HindIII D fragment of vaccinia virus (VV). The two near-terminal fragments, encompassing 14.2 and 3.6 kb, are respectively located 2.1 kb internal to the left and right cross-linked termini of the DNA and span the TIR junctions. The sequences encode 25 open reading frames including numerous proteins predicted to be membrane-bound or secreted in infected cells. Several ORFs unique to SPV were identified that may be involved in cell attachment, immune modulation, and pathogenesis including a novel poxvirus G protein-coupled receptor. In addition, several polypeptides encoded within the near-terminal regions of vaccinia virus DNA that function as host range or virulence factors are lacking within this region of swinepox virus including the VV growth factor, complement-binding protein, and ORFs C7L and K1L, associated with host range. The lack of these functional homologues could explain the characteristic attenuated phenotype and limited host range of SPV.

  9. Environmental analysis support

    Energy Technology Data Exchange (ETDEWEB)

    Miller, R.L.

    1996-06-01

    Activities in environmental analysis support included assistance to the Morgantown and Pittsburgh Energy Technology Centers (METC and PETC) in reviewing and preparing documents required by the National Environmental Policy Act (NEPA) for projects selected for the Clean Coal Technology (CCT) Program. An important activity was the preparation for METC of a final Environmental Assessment (EA) for the proposed Externally Fired Combined Cycle (EFCC) Project in Warren, Pennsylvania. In addition, a post-project environmental analysis was prepared for PETC to evaluate the Demonstration of Advanced Combustion Techniques for a Tangentially-Fired Boiler in Lynn Haven, Florida.

  10. Supporting elephant conservation in Sri Lanka through MODIS imagery

    Science.gov (United States)

    Perera, Kithsiri; Tateishi, Ryutaro

    2012-10-01

    The latest national elephant survey of Sri Lanka (2011) revealed Sri Lanka has 5,879 elephants. The total forest cover for these elephants is about 19,500 sq km (2012 estimation) and estimated forest area is about 30% of the country when smaller green patches are also counted. However, studies have pointed out that a herd of elephants need about a 100 sq km of forest patch to survive. With a high human population density (332 people per sq km, 2010), the pressure for land to feed people and elephants is becoming critical. Resent reports have indicated about 250 elephants are killed annually by farmers and dozens of people are also killed by elephants. Under this context, researchers are investigating various methods to assess the elephant movements to address the issues of Human-Elephant-Conflict (HEC). Apart from various local remedies for the issue, the conservation of elephant population can be supported by satellite imagery based studies. MODIS sensor imagery can be considered as a successful candidate here. Its spatial resolution is low (250m x 250m) but automatically filters out small forest patches in the mapping process. The daily imagery helps to monitor temporal forest cover changes. This study investigated the background information of HEC and used MODIS 250m imagery to suggest applicability of satellite data for Elephant conservations efforts. The elephant movement information was gathered from local authorities and potentials to identify bio-corridors were discussed. Under future research steps, regular forest cover monitoring through MODIS data was emphasized as a valuable tool in elephant conservations efforts.

  11. The impacts of tourism on coral reef conservation awareness and support in coastal communities in Belize

    Science.gov (United States)

    Diedrich, A.

    2007-12-01

    Marine recreational tourism is one of a number of threats to the Belize Barrier Reef but, conversely, represents both a motivation and source of resources for its conservation. The growth of tourism in Belize has resulted in the fact that many coastal communities are in varying stages of a socio-economic shift from dependence on fishing to dependence on tourism. In a nation becoming increasingly dependent on the health of its coral reef ecosystems for economic prosperity, a shift from extractive uses to their preservation is both necessary and logical. Through examining local perception data in five coastal communities in Belize, each attracting different levels of coral reef related tourism, this analysis is intended to explore the relationship between tourism development and local coral reef conservation awareness and support. The results of the analysis show a positive correlation between tourism development and coral reef conservation awareness and support in the study communities. The results also show a positive correlation between tourism development and local perceptions of quality of life, a trend that is most likely the source of the observed relationship between tourism and conservation. The study concludes that, because the observed relationship may be dependent on continued benefits from tourism as opposed to a perceived crisis in coral reef health, Belize must pay close attention to tourism impacts in the future. Failure to do this could result in a destructive feedback loop that would contribute to the degradation of the reef and, ultimately, Belize’s diminished competitiveness in the ecotourism market.

  12. Social-psychological principles of community-based conservation and conservancy motivation: attaining goals within an autonomy-supportive environment.

    Science.gov (United States)

    Decaro, Daniel; Stokes, Michael

    2008-12-01

    Community-based natural resource conservation programs in developing nations face many implementation challenges underpinned by social-psychological mechanisms. One challenge is garnering local support in an economically and socially sustainable fashion despite economic hardship and historical alienation from local resources. Unfortunately, conservationists' limited understanding of the social-psychological mechanisms underlying participatory conservation impedes the search for appropriate solutions. We address this issue by revealing key underlying social-psychological mechanisms of participatory conservation. Different administrative designs create social atmospheres that differentially affect endorsement of conservation goals. Certain forms of endorsement may be less effective motivators and less economically and socially sustainable than others. From a literature review we found that conservation initiatives endorsed primarily for nonautonomous instrumental reasons, such as to avoid economic fines or to secure economic rewards, are less motivating than those endorsed for autonomous reasons, such as for the opportunity for personal expression and growth. We suggest that successful participatory programs promote autonomous endorsement of conservation through an administrative framework of autonomy support-free and open democratic participation in management, substantive recognition and inclusion of local stakeholder identity, and respectful, noncoercive social interaction. This framework of the autonomy-supportive environment (self-determination theory) has important implications for future research into program design and incentive-based conservation and identifies a testable social-psychological theory of conservancy motivation.

  13. GIS-decision support for Comprehensive Conservation Planning : Progress report

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Progress report on the GIS support the Upper Midwest Environmental Sciences Center (UMESC) is providing to the U.S. Fish and Wildlife Service (FWS) in the...

  14. Continuum analysis of biological systems conserved quantities, fluxes and forces

    CERN Document Server

    Suraishkumar, G K

    2014-01-01

    This book addresses the analysis, in the continuum regime, of biological systems at various scales, from the cellular level to the industrial one. It presents both fundamental conservation principles (mass, charge, momentum and energy) and relevant fluxes resulting from appropriate driving forces, which are important for the analysis, design and operation of biological systems. It includes the concept of charge conservation, an important principle for biological systems that is not explicitly covered in any other book of this kind. The book is organized in five parts: mass conservation; charge conservation; momentum conservation; energy conservation; and multiple conservations simultaneously applied. All mathematical aspects are presented step by step, allowing any reader with a basic mathematical background (calculus, differential equations, linear algebra, etc.) to follow the text with ease. The book promotes an intuitive understanding of all the relevant principles and in so doing facilitates their applica...

  15. Public support for conserving bird species runs counter to climate change impacts on their distributions

    DEFF Research Database (Denmark)

    Lundhede, Thomas; Jacobsen, Jette Bredahl; Hanley, Nick

    2014-01-01

    There is increasing evidence that global climate change will alter the spatiotemporal occurrences and abundances of many species at continental scales. This will have implications for efficient conservation of biodiversity. We investigate if the general public in Denmark are willing to pay...... believing climate change to be man-made and people more knowledgeable about birds tended to have higher WTP for conservation of native species, relative to other people, whereas their preferences for conserving immigrant species generally resembled those of other people. Conservation investments rely...... heavily on public funding and hence on public support. Our results suggest that cross-country coordination of conservation efforts under climate change will be challenging in terms of achieving an appropriate balance between cost-effectiveness in adaptation and the concerns of a general public who seem...

  16. Conservatively treated acetabular fractures: A retrospective analysis

    Directory of Open Access Journals (Sweden)

    Narender Kumar Magu

    2012-01-01

    Full Text Available Background: There are a few studies reporting the long term outcome of conservatively treated acetabular fractures. The present study aims to evaluate the quality of reduction, and radiological and functional outcome in displaced acetabular fractures treated conservatively. Materials and Methods: Sixty-nine patients (55 men and 14 women with 71 displaced acetabular fractures (mean age 38.6 years managed conservatively were retrospectively evaluated. There were 11 posterior wall, 5 posterior column, 6 anterior column, 13 transverse, 2 posterior column with posterior wall, 9 transverse with posterior wall, 6 T-shaped, 1 anterior column with posterior hemi-transverse, and 18 both-column fractures. The follow-up radiographs were graded according to the criteria developed by Matta J. Functional outcome was assessed using Harris hip score and Merle d′Aubigne and Postel score at final followup. Average follow-up was 4.34 years (range 2-11 years. Results: Patients with congruent reduction (n=45 had good or excellent functional outcome. Radiologic outcome in incongruent reduction (n=26 was good or excellent in 6 and fair or poor in 20 hips. The functional outcome in patients with incongruent reduction was good or excellent in 16 and satisfactory or poor in 10 hips. Good to excellent radiologic and functional outcome was achieved in all patients with posterior wall fractures including four having more than 50% of broken wall. Good to excellent functional outcome was observed in 88.8% of both-column fractures with secondary congruence despite medial subluxation. Conclusions: Nonoperative treatment of acetabular fractures can give good radiological and functional outcome in congruent reduction. Posterior wall fractures with a congruous joint without subluxation on computed tomography axial section, posterior column, anterior column, infratectal transverse or T-shaped, and both-column fractures may be managed conservatively. Small osteochondral fragments

  17. Can retention forestry help conserve biodiversity? A meta-analysis.

    Science.gov (United States)

    Fedrowitz, Katja; Koricheva, Julia; Baker, Susan C; Lindenmayer, David B; Palik, Brian; Rosenvald, Raul; Beese, William; Franklin, Jerry F; Kouki, Jari; Macdonald, Ellen; Messier, Christian; Sverdrup-Thygeson, Anne; Gustafsson, Lena

    2014-12-01

    consistent among taxonomic groups for forest and open-habitat species, respectively. Synthesis and applications. Our meta-analysis provides support for wider use of retention forestry since it moderates negative harvesting impacts on biodiversity. Hence, it is a promising approach for integrating biodiversity conservation and production forestry, although identifying optimal solutions between these two goals may need further attention. Nevertheless, retention forestry will not substitute for conservation actions targeting certain highly specialized species associated with forest-interior or open-habitat conditions. Our meta-analysis provides support for wider use of retention forestry since it moderates negative harvesting impacts on biodiversity. Hence, it is a promising approach for integrating biodiversity conservation and production forestry, although identifying optimal solutions between these two goals may need further attention. Nevertheless, retention forestry will not substitute for conservation actions targeting certain highly specialized species associated with forest-interior or open-habitat conditions.

  18. Using Post-Visit Action Resources to Support Family Conservation Learning Following a Wildlife Tourism Experience

    Science.gov (United States)

    Hughes, Karen; Packer, Jan; Ballantyne, Roy

    2011-01-01

    Wildlife tourism experiences are often promoted for their ability to enhance visitors' conservation knowledge, attitudes and behaviour; yet, studies exploring the long-term influence of such experiences are rare. This research explores the impact of a wildlife tourism experience and post-visit support on families' adoption of conservation…

  19. Genetic diversity of Vietnamese domestic chicken populations as decision-making support for conservation strategies

    NARCIS (Netherlands)

    Pham, H.T.M.; Berthouly-Salazar, C.; Crooijmans, R.P.M.A.

    2013-01-01

    The aims of this study were to assess the genetic diversity of 17 populations of Vietnamese local chickens (VNN) and one Red Jungle Fowl population, together with six chicken populations of Chinese origin (CNO), and to provide priorities supporting the conservation of genetic resources using 20 micr

  20. Gap analysis and conservation network for freshwater wetlands in Central Yangtze Ecoregion.

    Science.gov (United States)

    Xiaowen, Li; Haijin, Zhuge; Li, Mengdi

    2013-01-01

    The Central Yangtze Ecoregion contains a large area of internationally important freshwater wetlands and supports a huge number of endangered waterbirds; however, these unique wetlands and the biodiversity they support are under the constant threats of human development pressures, and the prevailing conservation strategies generated based on the local scale cannot adequately be used as guidelines for ecoregion-based conservation initiatives for Central Yangtze at the broad scale. This paper aims at establishing and optimizing an ecological network for freshwater wetland conservation in the Central Yangtze Ecoregion based on large-scale gap analysis. A group of focal species and GIS-based extrapolation technique were employed to identify the potential habitats and conservation gaps, and the optimized conservation network was then established by combining existing protective system and identified conservation gaps. Our results show that only 23.49% of the potential habitats of the focal species have been included in the existing nature reserves in the Central Yangtze Ecoregion. To effectively conserve over 80% of the potential habitats for the focal species by optimizing the existing conservation network for the freshwater wetlands in Central Yangtze Ecoregion, it is necessary to establish new wetland nature reserves in 22 county units across Hubei, Anhui, and Jiangxi provinces.

  1. Hyperbolic Conservation Laws and Related Analysis with Applications

    CERN Document Server

    Holden, Helge; Karlsen, Kenneth

    2014-01-01

    This book presents thirteen papers, representing the most significant advances and current trends in nonlinear hyperbolic conservation laws and related analysis with applications. Topics covered include a survey on multidimensional systems of conservation laws as well as novel results  on liquid crystals, conservation laws with discontinuous flux functions, and applications to sedimentation.  Also included are articles on recent advances in the Euler equations and the Navier-Stokes-Fourier-Poisson system, in addition to new results on collective phenomena described by the Cucker-Smale model.    The Workshop on Hyperbolic Conservation Laws and Related Analysis with Applications at the International Centre for Mathematical Sciences (Edinburgh, UK) held in Edinburgh, September 2011, produced this fine collection of original research and survey articles. Many leading mathematicians attended the event and submitted their contributions for this volume. It is addressed to researchers and graduate students inter...

  2. Devising appropriate policies and instruments in support of private conservation areas: lessons learned from the Klein Karoo, South Africa.

    Science.gov (United States)

    Pasquini, Lorena; Cowling, Richard M; Twyman, Chasca; Wainwright, John

    2010-04-01

    The amount of privately conserved land is increasing worldwide. The potential of these areas to contribute to the global conservation of biodiversity is significant, given that statutory protected areas alone will not suffice. Nevertheless, there is still inadequate support for private conservation areas, and further research on appropriate, flexible, and generally applicable incentive measures is necessary. We conducted 25 semistructured interviews with the owners of private conservation areas in the Little Karoo, South Africa, to examine landowner opinions of existing conservation policies and their relationships with the local conservation authority. We also assessed landowner preferences regarding conservation incentive measures. Landowners doubted the conservation authority's capacity to implement its stewardship program and were also discouraged by the bureaucracy of the program. The conservation authority was often viewed negatively, except where landowners had experienced personal contact from conservation staff or where strong social capital had formed among landowners. Landowners did not desire financial rewards for their conservation efforts, but sought recognition of their stewardship role and greater involvement from the conservation authority through personal contact. We conclude that conservation policies for private lands could benefit from the provision of extension services to landowners, promotion of formation of groups of landowners and other stakeholders, and public acknowledgment of the contributions private conservation areas make.

  3. Emergency petroleum conservation: a review and analysis of selected measures

    Energy Technology Data Exchange (ETDEWEB)

    Boercker, F.D.; Balasubramaniam, M.; Hull, E.; Savadelis, J.; Valentini, J.J.

    1980-01-01

    ORNL was asked by the Economic Regulatory Administration to (1) collect, screen, and recommend a limited number of emergency measures that might conserve petroleum in residential and commercial buildings and in commercial transportation and (2) provide a detailed analysis of the energy savings and the economic and environmental impacts associated with restricting the hours of operation of commercial buildings. A total of 41 emergency measures were identified that might conserve petroleum, and these were reduced to a list of five that seemed most promising. Analysis of the measure to restrict hours of operation for commercial buildings shows that it might save 4 to 6% of annual commercial building energy use. The type of fuel conserved would vary widely from region to region, and appreciable negative economic impacts would result from implementing the measure.

  4. Challenging the win-win discourse on conservation and development: analyzing support for marine protected areas

    Directory of Open Access Journals (Sweden)

    Tomas Chaigneau

    2016-03-01

    Full Text Available Conservation designations such as protected areas are increasing in numbers around the world, yet it is widely reported that many are failing to reach their objectives. They are frequently promoted as opportunities for win-win outcomes that can both protect biodiversity and lead to economic benefits for affected communities. This win-win view characterizes the dominant discourse surrounding many protected areas. Although this discourse and the arguments derived from it may lead to initial acceptance of conservation interventions, this study shows how it does not necessarily result in compliance and positive attitudes toward specific protected areas. Consequently, the discourse has important implications not just for making the case for protected area implementation, but also for the likelihood of protected areas reaching their objectives. We explain how the win-win discourse influences support for marine protected areas (MPAs and, ultimately, their success. Using data from focus groups, questionnaires, and in-depth interviews at three MPA sites in the Philippines, we identified three reasons why the win-win discourse can negatively influence prolonged support for MPAs: dashed expectations, inequity, and temptation. Through an understanding of these issues, it becomes possible to suggest improvements that can be made pre-MPA implementation that can lead to prolonged support of MPAs. A focus on less tangible and economic MPA benefits, aligning MPA goals with cultural and social values, and higher levels of transparency when describing MPA outcomes are all ways in which prolonged support of MPAs can be bolstered.

  5. Analysis of alternative strategies for energy conservation in new buildings

    Energy Technology Data Exchange (ETDEWEB)

    Fang, J.M.; Tawil, J.J.

    1980-12-01

    Building Energy Performance Standards (BEPS) were mandated by the Energy Conservation Standards for New Buildings Act of 1976 (Title III of Energy Conservation and Production Act) to promote energy efficiency and the use of renewable resources in new buildings. The report analyzes alternative Federal strategies and their component policy instruments and recommends a strategy for achieving the goals of the Act. The concern is limited to space conditioning (heating, cooling, and lighting) and water heating. The policy instruments considered include greater reliance on market forces; research and development; information, education and demonstration programs; tax incentives and sanctions; mortgage and finance programs; and regulations and standards. The analysis starts with an explanation of the barriers to energy conservation in the residential and commercial sectors. Individual policy instruments are then described and evaluated with respect to energy conservation, economic efficiency, equity, political impacts, and implementation and other transitional impacts. Five possible strategies are identified: (1) increased reliance on the market place; (2) energy consumption tax and supply subsidies; (3) BEPS with no sanctions and no incentives; (4) BEPS with sanctions and incentives (price control); and (5) BEPS with sanctions and incentives (no price controls). A comparative analysis is performed. Elements are proposed for inclusion in a comprehensive strategy for conservation in new buildings. (MCW)

  6. Economic analysis of wildlife conservation in crop farming

    NARCIS (Netherlands)

    Wenum, van J.H.

    2002-01-01

    The general objective of this thesis was to present an economic analysis of wildlife conservation in Dutch crop farming. This general objective was broken down into 5 specific research objectives around which the research was organised: (1) selection and definition of appropriate indicators for wild

  7. On Symmetry Analysis and Conservation Laws of the AKNS System

    Science.gov (United States)

    Zhao, Zhonglong; Han, Bo

    2016-08-01

    The Lie symmetry analysis is applied to study the Ablowitz-Kaup-Newell-Segur (AKNS) system of water wave model. The AKNS system can be obtained from a dispersive-wave system via a variable transformation. Lie point symmetries and corresponding point transformations are determined. The optimal system of one-dimensional subalgebras is presented. On the basis of the optimal system, the similarity reductions and the invariant solutions are obtained. Some conservation laws are derived using the multipliers. In addition, the AKNS system is quasi self-adjoint. The conservation laws associated with the symmetries are also constructed.

  8. Structural Simulations and Conservation Analysis -Historic Building Information Model (HBIM

    Directory of Open Access Journals (Sweden)

    C. Dore

    2015-02-01

    Full Text Available In this paper the current findings to date of the Historic Building Information Model (HBIM of the Four Courts in Dublin are presented. The Historic Building Information Model (HBIM forms the basis for both structural and conservation analysis to measure the impact of war damage which still impacts on the building. The laser scan survey was carried out in the summer of 2014 of the internal and external structure. After registration and processing of the laser scan survey, the HBIM was created of the damaged section of the building and is presented as two separate workflows in this paper. The first is the model created from historic data, the second a procedural and segmented model developed from laser scan survey of the war damaged drum and dome. From both models structural damage and decay simulations will be developed for documentation and conservation analysis.

  9. ECRB ALCOVE AND NICHE GROUND SUPPORT ANALYSIS

    Energy Technology Data Exchange (ETDEWEB)

    J.W. Keifer

    1999-05-09

    The purpose of the analysis is to provide design bases for Enhanced Characterization of the Repository Block (ECRB) alcove and niche ground support drawings. The objective is to evaluate the ESF Alcove Ground Support Analysis (Ref 5.1) to determine if the calculations technically bound the ECRB alcoves and to address specific differences in the conditions and constraints.

  10. Condition index monitoring supports conservation priorities for the protection of threatened grass-finch populations.

    Science.gov (United States)

    Maute, Kimberly; French, Kristine; Legge, Sarah; Astheimer, Lee; Garnett, Stephen

    2015-01-01

    Conservation agencies are often faced with the difficult task of prioritizing what recovery actions receive support. With the number of species under threat of decline growing globally, research that informs conservation priorities is greatly needed. The relative vulnerability of cryptic or nomadic species is often uncertain, because populations are difficult to monitor and local populations often seem stable in the short term. This uncertainty can lead to inaction when populations are in need of protection. We tested the feasibility of using differences in condition indices as an indication of population vulnerability to decline for related threatened Australian finch sub-species. The Gouldian finch represents a relatively well-studied endangered species, which has a seasonal and site-specific pattern of condition index variation that differs from the closely related non-declining long-tailed finch. We used Gouldian and long-tailed finch condition variation as a model to compare with lesser studied, threatened star and black-throated finches. We compared body condition (fat and muscle scores), haematocrit and stress levels (corticosterone) among populations, seasons and years to determine whether lesser studied finch populations matched the model of an endangered species or a non-declining species. While vulnerable finch populations often had lower muscle and higher fat and corticosterone concentrations during moult (seasonal pattern similar to Gouldian finches), haematocrit values did not differ among populations in a predictable way. Star and black-throated finch populations, which were predicted to be vulnerable to decline, showed evidence of poor condition during moult, supporting their status as vulnerable. Our findings highlight how measures of condition can provide insight into the relative vulnerability of animal and plant populations to decline and will allow the prioritization of efforts towards the populations most likely to be in jeopardy of extinction.

  11. Point Cloud Analysis for Conservation and Enhancement of Modernist Architecture

    Science.gov (United States)

    Balzani, M.; Maietti, F.; Mugayar Kühl, B.

    2017-02-01

    Documentation of cultural assets through improved acquisition processes for advanced 3D modelling is one of the main challenges to be faced in order to address, through digital representation, advanced analysis on shape, appearance and conservation condition of cultural heritage. 3D modelling can originate new avenues in the way tangible cultural heritage is studied, visualized, curated, displayed and monitored, improving key features such as analysis and visualization of material degradation and state of conservation. An applied research focused on the analysis of surface specifications and material properties by means of 3D laser scanner survey has been developed within the project of Digital Preservation of FAUUSP building, Faculdade de Arquitetura e Urbanismo da Universidade de São Paulo, Brazil. The integrated 3D survey has been performed by the DIAPReM Center of the Department of Architecture of the University of Ferrara in cooperation with the FAUUSP. The 3D survey has allowed the realization of a point cloud model of the external surfaces, as the basis to investigate in detail the formal characteristics, geometric textures and surface features. The digital geometric model was also the basis for processing the intensity values acquired by laser scanning instrument; this method of analysis was an essential integration to the macroscopic investigations in order to manage additional information related to surface characteristics displayable on the point cloud.

  12. Sediment Analysis Network for Decision Support (SANDS)

    Science.gov (United States)

    Hardin, D. M.; Keiser, K.; Graves, S. J.; Conover, H.; Ebersole, S.

    2009-12-01

    Since the year 2000, Eastern Louisiana, coastal Mississippi, Alabama, and the western Florida panhandle have been affected by 28 tropical storms, seven of which were hurricanes. These tropical cyclones have significantly altered normal coastal processes and characteristics in the Gulf region through sediment disturbance. Although tides, seasonality, and agricultural development influence suspended sediment and sediment deposition over periods of time, tropical storm activity has the capability of moving the largest sediment loads in the shortest periods of time for coastal areas. The importance of sediments upon water quality, coastal erosion, habitats and nutrients has made their study and monitoring vital to decision makers in the region. Currently agencies such as United States Army Corps of Engineers (USACE), NASA, and Geological Survey of Alabama (GSA) are employing a variety of in-situ and airborne based measurements to assess and monitor sediment loading and deposition. These methods provide highly accurate information but are limited in geographic range, are not continuous over a region and, in the case of airborne LIDAR are expensive and do not recur on a regular basis. Multi-temporal and multi-spectral satellite imagery that shows tropical-storm-induced suspended sediment and storm-surge sediment deposits can provide decision makers with immediate and long-term information about the impacts of tropical storms and hurricanes. It can also be valuable for those conducting research and for projects related to coastal issues such as recovery, planning, management, and mitigation. The recently awarded Sediment Analysis Network for Decision Support will generate decision support products using NASA satellite observations from MODIS, Landsat and SeaWiFS instruments to support resource management, planning, and decision making activities in the Gulf of Mexico. Specifically, SANDS will generate decision support products that address the impacts of tropical storms

  13. Conserved N-terminal negative charges support optimally efficient N-type inactivation of Kv1 channels.

    Directory of Open Access Journals (Sweden)

    Alison Prince

    Full Text Available N-type inactivation is produced by the binding of a potassium channel's N-terminus within the open pore, blocking conductance. Previous studies have found that introduction of negative charges into N-terminal inactivation domains disrupts inactivation; however, the Aplysia AKv1 N-type inactivation domain contains two negatively charged residues, E2 and E9. Rather than being unusual, sequence analysis shows that this N-terminal motif is highly conserved among Kv1 sequences across many phyla. Conservation analysis shows some tolerance at position 9 for other charged residues, like D9 and K9, whereas position 2 is highly conserved as E2. To examine the functional importance of these residues, site directed mutagenesis was performed and effects on inactivation were recorded by two electrode voltage clamp in Xenopus oocytes. We find that inclusion of charged residues at positions 2 and 9 prevents interactions with non-polar sites along the inactivation pathway increasing the efficiency of pore block. In addition, E2 appears to have additional specific electrostatic interactions that stabilize the inactivated state likely explaining its high level of conservation. One possible explanation for E2's unique importance, consistent with our data, is that E2 interacts electrostatically with a positive charge on the N-terminal amino group to stabilize the inactivation domain at the block site deep within the pore. Simple electrostatic modeling suggests that due to the non-polar environment in the pore in the blocked state, even a 1 Å larger separation between these charges, produced by the E2D substitution, would be sufficient to explain the 65× reduced affinity of the E2D N-terminus for the pore. Finally, our studies support a multi-step, multi-site N-type inactivation model where the N-terminus interacts deep within the pore in an extended like structure placing the most N-terminal residues 35% of the way across the electric field in the pore blocked

  14. Design and analysis of heliostat support structure

    Energy Technology Data Exchange (ETDEWEB)

    Zang Chuncheng; Wang Zhifeng [Inst. of Electrical Engineering, CAS, BJ (China); Liu Xiaobing; Zhang Xiliang [Himin Solar Energy Group Co. Ltd, Dezhou, SD (China); Wang Yanzhong [Beijing Univ. of Aeronautics and Astronautics, BJ (China)

    2008-07-01

    The design method of the heliostat support structure with the aim of reducing the cost maximally is described in this paper. In order to guarantee the strength, stiffness and stability of the structure, dynamic performance and static performance including internal stress and distortion are analyzed by means of VSAP (Visual Structural Analysis Program) finite element computational software. Then the support structure is optimized on the basis of the analysis. (orig.)

  15. Ecosystem services-based SWOT analysis of protected areas for conservation strategies.

    Science.gov (United States)

    Scolozzi, Rocco; Schirpke, Uta; Morri, Elisa; D'Amato, Dalia; Santolini, Riccardo

    2014-12-15

    An ecosystem services-based SWOT analysis is proposed in order to identify and quantify internal and external factors supporting or threatening the conservation effectiveness of protected areas. The proposed approach concerns both the ecological and the social perspective. Strengths and weaknesses, opportunities and threats were evaluated based on 12 selected environmental and socio-economic indicators for all terrestrial Italian protected areas, belonging to the Natura 2000 network, and for their 5-km buffer area. The indicators, used as criteria within a multi-criteria assessment, include: core area, cost-distance between protected areas, changes in ecosystem services values, intensification of land use, and urbanization. The results were aggregated for three biogeographical regions, Alpine, Continental, and Mediterranean, indicating that Alpine sites have more opportunities and strengths than Continental and Mediterranean sites. The results call attention to where connectivity and land-use changes may have stronger influence on protected areas, in particular, whereas urbanization or intensification of agriculture may hamper conservation goals of protected areas. The proposed SWOT analysis provides helpful information for a multiple scale perspective and for identifying conservation priorities and for defining management strategies to assure biodiversity conservation and ecosystem services provision.

  16. Identification of conserved regulatory elements by comparative genome analysis

    Directory of Open Access Journals (Sweden)

    Jareborg Niclas

    2003-05-01

    Full Text Available Abstract Background For genes that have been successfully delineated within the human genome sequence, most regulatory sequences remain to be elucidated. The annotation and interpretation process requires additional data resources and significant improvements in computational methods for the detection of regulatory regions. One approach of growing popularity is based on the preferential conservation of functional sequences over the course of evolution by selective pressure, termed 'phylogenetic footprinting'. Mutations are more likely to be disruptive if they appear in functional sites, resulting in a measurable difference in evolution rates between functional and non-functional genomic segments. Results We have devised a flexible suite of methods for the identification and visualization of conserved transcription-factor-binding sites. The system reports those putative transcription-factor-binding sites that are both situated in conserved regions and located as pairs of sites in equivalent positions in alignments between two orthologous sequences. An underlying collection of metazoan transcription-factor-binding profiles was assembled to facilitate the study. This approach results in a significant improvement in the detection of transcription-factor-binding sites because of an increased signal-to-noise ratio, as demonstrated with two sets of promoter sequences. The method is implemented as a graphical web application, ConSite, which is at the disposal of the scientific community at http://www.phylofoot.org/. Conclusions Phylogenetic footprinting dramatically improves the predictive selectivity of bioinformatic approaches to the analysis of promoter sequences. ConSite delivers unparalleled performance using a novel database of high-quality binding models for metazoan transcription factors. With a dynamic interface, this bioinformatics tool provides broad access to promoter analysis with phylogenetic footprinting.

  17. [Investigation and analysis of China residents' environmental conservation desire].

    Science.gov (United States)

    Cao, Shi-Xiong; Chen, Jun; Chen, Li; Gao, Wang-Sheng; Yin, Hong-Wei

    2007-09-01

    From the viewpoints of country's safety and residents' desire, this paper investigated and analyzed the factors affecting China residents' attitudes on environmental protection policies, and the implementing results of these polices. It was indicated that people have an enhanced consciousness on environmental protection, and the relations between this consciousness and economic growth fit Kuznets curve, because most of the poor people are living in the suburban or remote regions with bad or seriously degraded environment, while the fast development of urbanization accelerates the deterioration of urban environment. People are more concerned about environment deterioration, and support the governments' policies of environmental conservation. The environment policy-making should put more emphasis on developing economics, strengthening education, and improving residents' livelihood.

  18. Applications of a broad-spectrum tool for conservation and fisheries analysis: aquatic gap analysis

    Science.gov (United States)

    McKenna, James E.; Steen, Paul J.; Lyons, John; Stewart, Jana S.

    2009-01-01

    Natural resources support all of our social and economic activities, as well as our biological existence. Humans have little control over most of the physical, biological, and sociological conditions dictating the status and capacity of natural resources in any particular area. However, the most rapid and threatening influences on natural resources typically are anthropogenic overuse and degradation. In addition, living natural resources (i.e., organisms) do not respect political boundaries, but are aware of their optimal habitat and environmental conditions. Most organisms have wider spatial ranges than the jurisdictional boundaries of environmental agencies that deal with them; even within those jurisdictions, information is patchy and disconnected. Planning and projecting effects of ecological management are difficult, because many organisms, habitat conditions, and interactions are involved. Conservation and responsible resource use involves wise management and manipulation of the aspects of the environment and biological communities that can be effectively changed. Tools and data sets that provide new insights and analysis capabilities can enhance the ability of resource managers to make wise decisions and plan effective, long-term management strategies. Aquatic gap analysis has been developed to provide those benefits. Gap analysis is more than just the assessment of the match or mis-match (i.e., gaps) between habitats of ecological value and areas with an appropriate level of environmental protection (e.g., refuges, parks, preserves), as the name suggests. Rather, a Gap Analysis project is a process which leads to an organized database of georeferenced information and previously available tools to examine conservation and other ecological issues; it provides a geographic analysis platform that serves as a foundation for aquatic ecological studies. This analytical tool box allows one to conduct assessments of all habitat elements within an area of interest

  19. A web based spatial decision supporting system for land management and soil conservation

    Directory of Open Access Journals (Sweden)

    F. Terribile

    2015-02-01

    Full Text Available Today it is evident that there are many contrasting demands on our landscape (e.g. food security, more sustainable agriculture, higher income in rural areas, etc. but also many land degradation problems. It has been proved that providing operational answers to these demands and problems is extremely difficult. Here we aim to demonstrate that a Spatial Decision Support System based on geospatial cyber-infrastructure (GCI can embody all of the above, so producing a smart system for supporting decision making for agriculture, forestry and urban planning with respect to the landscape. In this paper, we discuss methods and results of a special kind of GCI architecture, one that is highly focused on soil and land conservation (SOILCONSWEB-LIFE+ project. The system allows us to obtain dynamic, multidisciplinary, multiscale, and multifunctional answers to agriculture, forestry and urban planning issues through the web. The system has been applied to and tested in an area of about 20 000 ha in the South of Italy, within the framework of a European LIFE+ project. The paper reports – as a case study – results from two different applications dealing with agriculture (olive growth tool and environmental protection (soil capability to protect groundwater. Developed with the help of end users, the system is starting to be adopted by local communities. The system indirectly explores a change of paradigm for soil and landscape scientists. Indeed, the potential benefit is shown of overcoming current disciplinary fragmentation over landscape issues by offering – through a smart web based system – truly integrated geospatial knowledge that may be directly and freely used by any end user (http://www.landconsultingweb.eu. This may help bridge the last much important divide between scientists working on the landscape and end users.

  20. A Web-based spatial decision supporting system for land management and soil conservation

    Science.gov (United States)

    Terribile, F.; Agrillo, A.; Bonfante, A.; Buscemi, G.; Colandrea, M.; D'Antonio, A.; De Mascellis, R.; De Michele, C.; Langella, G.; Manna, P.; Marotta, L.; Mileti, F. A.; Minieri, L.; Orefice, N.; Valentini, S.; Vingiani, S.; Basile, A.

    2015-07-01

    Today it is evident that there are many contrasting demands on our landscape (e.g. food security, more sustainable agriculture, higher income in rural areas, etc.) as well as many land degradation problems. It has been proved that providing operational answers to these demands and problems is extremely difficult. Here we aim to demonstrate that a spatial decision support system based on geospatial cyberinfrastructure (GCI) can address all of the above, so producing a smart system for supporting decision making for agriculture, forestry, and urban planning with respect to the landscape. In this paper, we discuss methods and results of a special kind of GCI architecture, one that is highly focused on land management and soil conservation. The system allows us to obtain dynamic, multidisciplinary, multiscale, and multifunctional answers to agriculture, forestry, and urban planning issues through the Web. The system has been applied to and tested in an area of about 20 000 ha in the south of Italy, within the framework of a European LIFE+ project (SOILCONSWEB). The paper reports - as a case study - results from two different applications dealing with agriculture (olive growth tool) and environmental protection (soil capability to protect groundwater). Developed with the help of end users, the system is starting to be adopted by local communities. The system indirectly explores a change of paradigm for soil and landscape scientists. Indeed, the potential benefit is shown of overcoming current disciplinary fragmentation over landscape issues by offering - through a smart Web-based system - truly integrated geospatial knowledge that may be directly and freely used by any end user (www.landconsultingweb.eu). This may help bridge the last very important divide between scientists working on the landscape and end users.

  1. A web based spatial decision supporting system for land management and soil conservation

    Science.gov (United States)

    Terribile, F.; Agrillo, A.; Bonfante, A.; Buscemi, G.; Colandrea, M.; D'Antonio, A.; De Mascellis, R.; De Michele, C.; Langella, G.; Manna, P.; Marotta, L.; Mileti, F. A.; Minieri, L.; Orefice, N.; Valentini, S.; Vingiani, S.; Basile, A.

    2015-02-01

    Today it is evident that there are many contrasting demands on our landscape (e.g. food security, more sustainable agriculture, higher income in rural areas, etc.) but also many land degradation problems. It has been proved that providing operational answers to these demands and problems is extremely difficult. Here we aim to demonstrate that a Spatial Decision Support System based on geospatial cyber-infrastructure (GCI) can embody all of the above, so producing a smart system for supporting decision making for agriculture, forestry and urban planning with respect to the landscape. In this paper, we discuss methods and results of a special kind of GCI architecture, one that is highly focused on soil and land conservation (SOILCONSWEB-LIFE+ project). The system allows us to obtain dynamic, multidisciplinary, multiscale, and multifunctional answers to agriculture, forestry and urban planning issues through the web. The system has been applied to and tested in an area of about 20 000 ha in the South of Italy, within the framework of a European LIFE+ project. The paper reports - as a case study - results from two different applications dealing with agriculture (olive growth tool) and environmental protection (soil capability to protect groundwater). Developed with the help of end users, the system is starting to be adopted by local communities. The system indirectly explores a change of paradigm for soil and landscape scientists. Indeed, the potential benefit is shown of overcoming current disciplinary fragmentation over landscape issues by offering - through a smart web based system - truly integrated geospatial knowledge that may be directly and freely used by any end user (http://www.landconsultingweb.eu). This may help bridge the last much important divide between scientists working on the landscape and end users.

  2. China’s Structural Energy Conservation: Analysis and Proposals

    Institute of Scientific and Technical Information of China (English)

    张雷; 黄园淅

    2008-01-01

    Given the increasing dependence of development on energy consumption, an understanding of the rules and trends of national energy consumption is required for boosting social energy conservation. By using two models -- the structural evolution energy consumption model and the structural evolution per-unit energy consumption model, this article attempts to make an international comparison of the industrial structure development versus energy consumption patterns in the United States, the United Kingdom, France, Germany, Japan, and India. The results of this analysis indicate that the dominance of secondary industry over the industrial structure evolution process noticeably accelerates national energy consumption at the initial stage of modernization. Subsequently, a slowdown in energy consumption as a result of industrial structure development yields effects as the diversification process speeds up. Under such influence, energy consumption per unit of GDP follows an inverted U-shaped curve from rise to decline. As one of the world’s major energy producers and consumers, China has long employed a one- sided sector development policy. Under the influence of this policy, national energy conservation endeavors have been inhibited by the rigidity in its industry structural evolution. Thus, in China, energy consumption per unit of GDP has remained at a high level.

  3. Discovery and analysis of evolutionarily conserved intronic splicing regulatory elements.

    Directory of Open Access Journals (Sweden)

    Gene W Yeo

    2007-05-01

    Full Text Available Knowledge of the functional cis-regulatory elements that regulate constitutive and alternative pre-mRNA splicing is fundamental for biology and medicine. Here we undertook a genome-wide comparative genomics approach using available mammalian genomes to identify conserved intronic splicing regulatory elements (ISREs. Our approach yielded 314 ISREs, and insertions of ~70 ISREs between competing splice sites demonstrated that 84% of ISREs altered 5' and 94% altered 3' splice site choice in human cells. Consistent with our experiments, comparisons of ISREs to known splicing regulatory elements revealed that 40%-45% of ISREs might have dual roles as exonic splicing silencers. Supporting a role for ISREs in alternative splicing, we found that 30%-50% of ISREs were enriched near alternatively spliced (AS exons, and included almost all known binding sites of tissue-specific alternative splicing factors. Further, we observed that genes harboring ISRE-proximal exons have biases for tissue expression and molecular functions that are ISRE-specific. Finally, we discovered that for Nova1, neuronal PTB, hnRNP C, and FOX1, the most frequently occurring ISRE proximal to an alternative conserved exon in the splicing factor strongly resembled its own known RNA binding site, suggesting a novel application of ISRE density and the propensity for splicing factors to auto-regulate to associate RNA binding sites to splicing factors. Our results demonstrate that ISREs are crucial building blocks in understanding general and tissue-specific AS regulation and the biological pathways and functions regulated by these AS events.

  4. A conservation ontology and knowledge base to support delivery of technical assistance to agricultural producers in the united states

    Science.gov (United States)

    Information systems supporting the delivery of conservation technical assistance by the United States Department of Agriculture (USDA) to agricultural producers on working lands have become increasingly complex over the past 25 years. They are constrained by inconsistent coordination of domain knowl...

  5. Is it appropriate to support the farmers for adopting conservation agriculture? Economic and environmental impact assessment

    Directory of Open Access Journals (Sweden)

    Antonio Troccoli

    2015-12-01

    Full Text Available Conservation agriculture (CA in the last decades has been spread in several parts of the world, especially in South and North America and Australia. In Italy, however, its adoption is often restrained by the risk to have a reduction in crop production in the early years of transition from conventional (CT to CA. To quantify sufficient financial support to promote no-tillage and CA, a mini-review about main effects of CA was conducted. The effect on crop yield, soil fertility - especially as it is influenced by the chemical, physical and microbiological factors - on soil compaction, the economic balance of the farm and the cost of equipment for direct seeding, the influence of environment on soil erosion, water retention, emissions of greenhouse gases, and carbon sequestration are briefly treated. The paper reports findings from national and international scientific literature and some results from long-term experiments conducted in Southern Italy. The main conclusions are about the reduction of yield in the first years of transition from CT to CA (from -5 to -10%, an improvement of soil fertility (soil organic carbon increases in the upper layers, reduction of management cost (less machinery operations, improvement of soil C sequestration (in specific conditions, a reduction of greenhouse gases emission and soil erosion risk. The paper provides the scientific basis in order to justify and quantify the amount to be paid to the farmers who decide to adopt the model of CA, oriented to protect the agro-ecosystem and to promote the principle of subsidiarity. Finally, a proposal of public subsidy in cash and for machinery purchase has been described.

  6. Supporting food security in the 21st century through resource-conserving increases in agricultural production

    Directory of Open Access Journals (Sweden)

    Uphoff Norman

    2012-12-01

    Full Text Available Abstract The Green Revolution was accomplished under a set of demographic, economic, climatic and other conditions in the 20th century that have been changing and will surely be different and more difficult in the decades ahead. The suitability and sustainability of any given agricultural technology depends on factors like resource availability and productivity, energy costs, and environmental constraints. The achievements of Green Revolution technologies in the 1960s and 1970s came at a critical time of impending food shortages, and the world’s people would be worse off without them. However, the rate of yield improvement for cereal production has been slowing since the mid-1980s. Looking ahead at the foreseeable circumstances under which 21st century agricultural producers must try to assure food security, there will be need for technologies that are less dependent on resources that are becoming relatively scarcer, like arable land and water, or becoming relatively more costly, like energy and petrochemical-based inputs. This paper considers agroecologically-based innovations that reduce farmers’ dependence on external inputs, relying more on endogenous processes and existing potentials in plants and soil systems. Such resource-conserving production represents a different approach to meeting food security goals. While these innovations are not yet fully understood and are still being researched, there are good agronomic reasons to account for their effectiveness, and scientific validations are accumulating. Enough successes have been recorded from making changes in the management of plants, soil, water and nutrients that more attention from researchers, policy-makers and practitioners is warranted, especially given the need to adapt to, and to mitigate the effects of, climate change. The same agroecological concepts and management methods that are enhancing factor productivity in rice production are giving similar results with other crops

  7. Positive Behavior Support and Applied Behavior Analysis

    Science.gov (United States)

    Johnston, J. M.; Foxx, R. M.; Jacobson, J. W.; Green, G.; Mulick, J. A.

    2006-01-01

    This article reviews the origins and characteristics of the positive behavior support (PBS) movement and examines those features in the context of the field of applied behavior analysis (ABA). We raise a number of concerns about PBS as an approach to delivery of behavioral services and its impact on how ABA is viewed by those in human services. We…

  8. Principles and Best Practices Emerging from Data Basin: A Data Platform Supporting Scientific Research and Landscape Conservation Planning

    Science.gov (United States)

    Comendant, T.; Strittholt, J. R.; Ward, B. C.; Bachelet, D. M.; Grossman, D.; Stevenson-Molnar, N.; Henifin, K.; Lundin, M.; Marvin, T. S.; Peterman, W. L.; Corrigan, G. N.; O'Connor, K.

    2013-12-01

    A multi-disciplinary team of scientists, software engineers, and outreach staff at the Conservation Biology Institute launched an open-access, web-based spatial data platform called Data Basin (www.databasin.org) in 2010. Primarily built to support research and environmental resource planning, Data Basin provides the capability for individuals and organizations to explore, create, interpret, and collaborate around their priority topics and geographies. We used a stakeholder analysis to assess the needs of data consumers/produces and help prioritize primary and secondary audiences. Data Basin's simple and user-friendly interface makes mapping and geo-processing tools more accessible to less technical audiences. Input from users is considered in system planning, testing, and implementation. The team continually develops using an agile software development approach, which allows new features, improvements, and bug fixes to be deployed to the live system on a frequent basis. The data import process is handled through administrative approval and Data Basin requires spatial data (biological, physical, and socio-economic) to be well-documented. Outreach and training is used to convey the scope and appropriate use of the scientific information and available resources.

  9. Using Bayesian Population Viability Analysis to Define Relevant Conservation Objectives.

    Directory of Open Access Journals (Sweden)

    Adam W Green

    Full Text Available Adaptive management provides a useful framework for managing natural resources in the face of uncertainty. An important component of adaptive management is identifying clear, measurable conservation objectives that reflect the desired outcomes of stakeholders. A common objective is to have a sustainable population, or metapopulation, but it can be difficult to quantify a threshold above which such a population is likely to persist. We performed a Bayesian metapopulation viability analysis (BMPVA using a dynamic occupancy model to quantify the characteristics of two wood frog (Lithobates sylvatica metapopulations resulting in sustainable populations, and we demonstrate how the results could be used to define meaningful objectives that serve as the basis of adaptive management. We explored scenarios involving metapopulations with different numbers of patches (pools using estimates of breeding occurrence and successful metamorphosis from two study areas to estimate the probability of quasi-extinction and calculate the proportion of vernal pools producing metamorphs. Our results suggest that ≥50 pools are required to ensure long-term persistence with approximately 16% of pools producing metamorphs in stable metapopulations. We demonstrate one way to incorporate the BMPVA results into a utility function that balances the trade-offs between ecological and financial objectives, which can be used in an adaptive management framework to make optimal, transparent decisions. Our approach provides a framework for using a standard method (i.e., PVA and available information to inform a formal decision process to determine optimal and timely management policies.

  10. Better economics: supporting adaptation with stakeholder analysis

    Energy Technology Data Exchange (ETDEWEB)

    Chambwera, Muyeye; Zou, Ye; Boughlala, Mohamed

    2011-11-15

    Across the developing world, decision makers understand the need to adapt to climate change — particularly in agriculture, which supports a large proportion of low-income groups who are especially vulnerable to impacts such as increasing water scarcity or more erratic weather. But policymakers are often less clear about what adaptation action to take. Cost-benefit analyses can provide information on the financial feasibility and economic efficiency of a given policy. But such methods fail to capture the non-monetary benefits of adaptation, which can be even more important than the monetary ones. Ongoing work in Morocco shows how combining cost-benefit analysis with a more participatory stakeholder analysis can support effective decision making by identifying cross-sector benefits, highlighting areas of mutual interest among different stakeholders and more effectively assessing impacts on adaptive capacity.

  11. DNA splice site sequences clustering method for conservativeness analysis

    Institute of Scientific and Technical Information of China (English)

    Quanwei Zhang; Qinke Peng; Tao Xu

    2009-01-01

    DNA sequences that are near to splice sites have remarkable conservativeness,and many researchers have contributed to the prediction of splice site.In order to mine the underlying biological knowledge,we analyze the conservativeness of DNA splice site adjacent sequences by clustering.Firstly,we propose a kind of DNA splice site sequences clustering method which is based on DBSCAN,and use four kinds of dissimilarity calculating methods.Then,we analyze the conservative feature of the clustering results and the experimental data set.

  12. An evolutionary conserved region (ECR in the human dopamine receptor D4 gene supports reporter gene expression in primary cultures derived from the rat cortex

    Directory of Open Access Journals (Sweden)

    Haddley Kate

    2011-05-01

    Full Text Available Abstract Background Detecting functional variants contributing to diversity of behaviour is crucial for dissecting genetics of complex behaviours. At a molecular level, characterisation of variation in exons has been studied as they are easily identified in the current genome annotation although the functional consequences are less well understood; however, it has been difficult to prioritise regions of non-coding DNA in which genetic variation could also have significant functional consequences. Comparison of multiple vertebrate genomes has allowed the identification of non-coding evolutionary conserved regions (ECRs, in which the degree of conservation can be comparable with exonic regions suggesting functional significance. Results We identified ECRs at the dopamine receptor D4 gene locus, an important gene for human behaviours. The most conserved non-coding ECR (D4ECR1 supported high reporter gene expression in primary cultures derived from neonate rat frontal cortex. Computer aided analysis of the sequence of the D4ECR1 indicated the potential transcription factors that could modulate its function. D4ECR1 contained multiple consensus sequences for binding the transcription factor Sp1, a factor previously implicated in DRD4 expression. Co-transfection experiments demonstrated that overexpression of Sp1 significantly decreased the activity of the D4ECR1 in vitro. Conclusion Bioinformatic analysis complemented by functional analysis of the DRD4 gene locus has identified a a strong enhancer that functions in neurons and b a transcription factor that may modulate the function of that enhancer.

  13. Comparative Analysis Of River Conservation In The United States And South Africa

    Science.gov (United States)

    Both the United States and South Africa are recognized for their strong and innovative approaches to the conservation of river ecosystems. These national programs possess similar driving legislation and ecoregional classification schemes supported by comprehensive monitoring prog...

  14. Scientific Data Analysis and Software Support: Geodynamics

    Science.gov (United States)

    Klosko, Steven; Sanchez, B. (Technical Monitor)

    2000-01-01

    The support on this contract centers on development of data analysis strategies, geodynamic models, and software codes to study four-dimensional geodynamic and oceanographic processes, as well as studies and mission support for near-Earth and interplanetary satellite missions. SRE had a subcontract to maintain the optical laboratory for the LTP, where instruments such as MOLA and GLAS are developed. NVI performed work on a Raytheon laser altimetry task through a subcontract, providing data analysis and final data production for distribution to users. HBG had a subcontract for specialized digital topography analysis and map generation. Over the course of this contract, Raytheon ITSS staff have supported over 60 individual tasks. Some tasks have remained in place during this entire interval whereas others have been completed and were of shorter duration. Over the course of events, task numbers were changed to reflect changes in the character of the work or new funding sources. The description presented below will detail the technical accomplishments that have been achieved according to their science and technology areas. What will be shown is a brief overview of the progress that has been made in each of these investigative and software development areas. Raytheon ITSS staff members have received many awards for their work on this contract, including GSFC Group Achievement Awards for TOPEX Precision Orbit Determination and the Joint Gravity Model One Team. NASA JPL gave the TOPEX/POSEIDON team a medal commemorating the completion of the primary mission and a Certificate of Appreciation. Raytheon ITSS has also received a Certificate of Appreciation from GSFC for its extensive support of the Shuttle Laser Altimeter Experiment.

  15. Empirical Evidence in Support of a Research-Informed Water Conservation Education Program

    Science.gov (United States)

    Thompson, Ruthanne; Serna, Victoria Faubion

    2016-01-01

    Based on results from a 2008 research study of regional citizen knowledge concerning watershed issues, a water conservation education program was designed and implemented. Findings from the initial study demonstrated program success as evidenced by knowledge gain and willingness to "commit" to water saving behaviors in 94% of students. A…

  16. Use of monitoring data to support conservation management and policy decisions in Micronesia.

    Science.gov (United States)

    Montambault, Jensen Reitz; Wongbusarakum, Supin; Leberer, Trina; Joseph, Eugene; Andrew, Wayne; Castro, Fran; Nevitt, Brooke; Golbuu, Yimnang; Oldiais, Noelle W; Groves, Craig R; Kostka, Willy; Houk, Peter

    2015-10-01

    Adaptive management implies a continuous knowledge-based decision-making process in conservation. Yet, the coupling of scientific monitoring and management frameworks remains rare in practice because formal and informal communication pathways are lacking. We examined 4 cases in Micronesia where conservation practitioners are using new knowledge in the form of monitoring data to advance marine conservation. These cases were drawn from projects in Micronesia Challenge jurisdictions that received funding for coupled monitoring-to-management frameworks and encompassed all segments of adaptive management. Monitoring in Helen Reef, Republic of Palau, was catalyzed by coral bleaching and revealed evidence of overfishing that led to increased enforcement and outreach. In Nimpal Channel, Yap, Federated States of Micronesia (FSM), monitoring the recovery of marine food resources after customary restrictions were put in place led to new, more effective enforcement approaches. Monitoring in Laolao Bay, Saipan, Commonwealth of the Northern Mariana Islands, was catalyzed by observable sediment loads from poor land-use practices and resulted in actions that reduced land-based threats, particularly littering and illegal burning, and revealed additional threats from overfishing. Pohnpei (FSM) began monitoring after observed declines in grouper spawning aggregations. This data led to adjusting marine conservation area boundaries and implementing market-based size class restrictions. Two themes emerged from these cases. First, in each case monitoring was conducted in a manner relevant to the social and ecological systems and integrated into the decision-making process. Second, conservation practitioners and scientists in these cases integrated culturally appropriate stakeholder engagement throughout all phases of the adaptive management cycle. More broadly, our study suggests, when describing adaptive management, providing more details on how monitoring and management activities are

  17. Delimiting priority areas for the conservation of endemic and threatened Neotropical birds using a niche-based gap analysis

    Science.gov (United States)

    Sousa-Neves, Tiago; Cerqueira, Pablo Vieira; Gonsioroski, Gustavo; Silva, Sofia Marques; Silva, Daniel Paiva; Santos, Marcos Pérsio Dantas

    2017-01-01

    Knowledge of spatiotemporal distribution of biodiversity is still very incomplete in the tropics. This is one of the major problems preventing the assessment and effectiveness of conservation actions. Mega-diverse tropical regions are being exposed to fast and profound environmental changes, and the amount of resources available to describe the distribution of species is generally limited. Thus, the tropics is losing species at unprecedented rates, without a proper assessment of its biodiversity. Species distribution models (SDMs) can be used to fill such biogeographic gaps within a species’ range and, when allied with systematic conservation planning (e.g. analyses of representativeness, gap analysis), help transcend such data shortage and support practical conservation actions. Within the Neotropics, eastern Amazon and northern Cerrado present a high variety of environments and are some of the most interesting ecotonal areas within South America, but are also among the most threatened biogeographic provinces in the world. Here, we test the effectiveness of the current system of Protected Areas (PAs), in protecting 24 threatened and endemic bird species using SDMs. We found that taxa with wider distributions are potentially as protected as taxa with smaller ranges, and larger PAs were more efficient than smaller PAs, while protecting these bird species. Nonetheless, Cerrado PAs are mostly misallocated. We suggest six priority areas for conservation of Neotropical birds. Finally, we highlight the importance of indigenous lands in the conservation of Neotropical biodiversity, and recommend the development of community management plans to conserve the biological resources of the region. PMID:28187182

  18. Dynamic Analysis of Foundation Supporting Rotary Machine

    Directory of Open Access Journals (Sweden)

    Utkarsh S. Patel

    2015-08-01

    Full Text Available With the advancement of technology in the field of industry, high speed machinery has been developed. As the speed of machinery has increased, vibrations also increased. Machines transmit vibrations to the structure supporting them. Hence, it is important to design and develop such structure which sustains the vibrations of machinery. Hence, in this study it has been aimed to execute the study on foundations supporting rotary type of machine like blower. In this paper, the most important parameters like frequency and amplitude are considered while execution of analysis of machine foundation supporting blower type machine. This paper shows, better interface between foundation designer and machine manufacturer for better performance of machine. The design aids/approaches for foundation design is also described in this paper and an attempt has been made to study the dynamic behaviour of a foundation structure for blower type machine subjected to forces due to operation of blower machine. Two different types of foundations for Rotary type Machine that is Blower have been studied in this paper

  19. Analysis of Schizosaccharomyces pombe mediator reveals a set of essential subunits conserved between yeast and metazoan cells

    DEFF Research Database (Denmark)

    Spåhr, H; Samuelsen, C O; Baraznenok, V;

    2001-01-01

    essential genes conserved between S. pombe and S. cerevisiae also have a metazoan homolog, indicating that an evolutionary conserved Mediator core is present in all eukaryotic cells. Our data suggest a closer functional relationship between yeast and metazoan Mediator than previously anticipated....... to any of the 10 S. cerevisiae components encoded by nonessential genes. S. pombe Mediator instead contains three unique components (Pmc2, -3, and -6), which lack homologs in other cell types. Presently, pmc2(+) and pmc3(+) have been shown to be nonessential genes. The data suggest that S. pombe and S....... cerevisiae share an essential protein module, which associates with nonessential speciesspecific subunits. In support of this view, sequence analysis of the conserved yeast Mediator components Med4 and Med8 reveals sequence homology to the metazoan Mediator components Trap36 and Arc32. Therefore, 8 of 10...

  20. Economic Analysis of Water Conservation Policies in the Texas Panhandle

    OpenAIRE

    Taylor, Robert H.; Almas, Lal K.; Colette, W. Arden

    2007-01-01

    Due to declining water availability from the Ogallala Aquifer, management policy alternatives for extending the life of the aquifer to sustain rural economies in the Texas Panhandle are evaluated. The study concludes that water conservation policies for the region significantly impact crop mix, resource usage, and net present value of farm profits over a sixty-year planning horizon.

  1. Economic analysis of water conservation policies in the Texas Panhandle

    Science.gov (United States)

    Due to declining water availability from the Ogallala Aquifer, management policy alternatives for extending the life of the aquifer to sustain rural economies in the Texas Panhandle are evaluated. The study concludes that water conservation policies for the region significantly impact crop mix, reso...

  2. Lie Symmetry Analysis and Conservation Laws of a Generalized Time Fractional Foam Drainage Equation

    Science.gov (United States)

    Wang, Li; Tian, Shou-Fu; Zhao, Zhen-Tao; Song, Xiao-Qiu

    2016-07-01

    In this paper, a generalized time fractional nonlinear foam drainage equation is investigated by means of the Lie group analysis method. Based on the Riemann—Liouville derivative, the Lie point symmetries and symmetry reductions of the equation are derived, respectively. Furthermore, conservation laws with two kinds of independent variables of the equation are performed by making use of the nonlinear self-adjointness method. Supported by the National Training Programs of Innovation and Entrepreneurship for Undergraduates under Grant No. 201410290039, the Fundamental Research Funds for the Central Universities under Grant Nos. 2015QNA53 and 2015XKQY14, the Fundamental Research Funds for Postdoctoral at the Key Laboratory of Gas and Fire Control for Coal Mines, the General Financial Grant from the China Postdoctoral Science Foundation under Grant No. 2015M570498, and Natural Sciences Foundation of China under Grant No. 11301527

  3. Symmetry analysis and conservation laws of the Drinfeld-Sokolov-Wilson system

    Science.gov (United States)

    Zhao, Zhonglong; Zhang, Yufeng; Han, Zhong

    2014-07-01

    In this paper, Lie symmetry analysis is performed on the Drinfeld-Sokolov-Wilson system. We get the corresponding Lie algebra and similarity reductions of the system. In addition, we utilize Noether's approach and the new conservation theorem deriving the conservation laws of this system.

  4. COSTSAFR 3. 0---User's manual: (Conservation Optimization Standard for Savings in Federal Residences): In support of proposed modifications to interim energy conservation standards for new federal residential buildings

    Energy Technology Data Exchange (ETDEWEB)

    1988-06-01

    This document describes how to use the computer program developed under the Federal Residential Standard Project funded by the Department of Energy. The computer program provides an analysis of specific housing projects at a given site, using alternative fuel types, and considering alternative housing types. Designed around the concept of minimizing overall costs through energy conservation design--including first cost and future utility costs--the computer program establishes a standard design to which proposed housing designs are compared. It then provides a point table, for each housing type, that can be used to determine whether a proposed design meets the standard and how a design could be modified to meet the standard. The computer program has been designed for IBM-PC or compatible computers and is recorded on a floppy disk. This manual describes how to use the program and how to read the information that appears on the screen during program operation. It describes the inputs required and the various options presented to the user. The appendices provide more detailed information related to the output produced by the program. This output consists of point tables presenting points for each energy conservation option, and a point total that must be met to comply with the standard. The technical support document and economic analysis are separate documents that provide more information about the specifics of the standard.

  5. SUPPORT VECTOR MACHINE FOR STRUCTURAL RELIABILITY ANALYSIS

    Institute of Scientific and Technical Information of China (English)

    LI Hong-shuang; L(U) Zhen-zhou; YUE Zhu-feng

    2006-01-01

    Support vector machine (SVM) was introduced to analyze the reliability of the implicit performance function, which is difficult to implement by the classical methods such as the first order reliability method (FORM) and the Monte Carlo simulation (MCS). As a classification method where the underlying structural risk minimization inference rule is employed, SVM possesses excellent learning capacity with a small amount of information and good capability of generalization over the complete data. Hence,two approaches, i.e., SVM-based FORM and SVM-based MCS, were presented for the structural reliability analysis of the implicit limit state function. Compared to the conventional response surface method (RSM) and the artificial neural network (ANN), which are widely used to replace the implicit state function for alleviating the computation cost,the more important advantages of SVM are that it can approximate the implicit function with higher precision and better generalization under the small amount of information and avoid the "curse of dimensionality". The SVM-based reliability approaches can approximate the actual performance function over the complete sampling data with the decreased number of the implicit performance function analysis (usually finite element analysis), and the computational precision can satisfy the engineering requirement, which are demonstrated by illustrations.

  6. Internet cancer support groups: a feminist analysis.

    Science.gov (United States)

    Im, Eun-Ok; Chee, Wonshik; Tsai, Hsiu-Min; Lin, Li-Chen; Cheng, Ching-Yu

    2005-01-01

    Internet Cancer Support Groups (ICSGs) are an emerging form of support group on Internet specifically for cancer patients. Previous studies have indicated the effectiveness of ICSGs as a research setting or a data-collection method. Yet recent studies have also indicated that ICSGs tend to serve highly educated, high-income White males who tend to be at an early stage of cancer. In this article, a total of 317 general ICSGs and 229 ethnic-specific ICSGs searched through Google.com, Yahoo.com, Msn.com, AOL.com, and ACOR.org are analyzed from a feminist perspective. The written records of group discussions and written memos by the research staff members were also analyzed using content analysis. The idea categories that emerged about these groups include (a) authenticity issues; (b) ethnicity and gender issues; (c) intersubjectivity issues; and (d) potential ethical issues. The findings suggest that (a) researchers adopt multiple recruitment strategies through various Internet sites and/or real settings; (b) researchers raise their own awareness of the potential influences of the health-related resources provided by ICSGs and regularly update their knowledge related to the federal and state standards and/or policies related to ICSGs; and (c) researchers consider adopting a quota-sampling method.

  7. Valuing investments in sustainable land management using an integrated modelling framework to support a watershed conservation scheme in the Upper Tana River, Kenya

    Science.gov (United States)

    Hunink, Johannes E.; Bryant, Benjamin P.; Vogl, Adrian; Droogers, Peter

    2015-04-01

    We analyse the multiple impacts of investments in sustainable land use practices on ecosystem services in the Upper Tana basin (Kenya) to support a watershed conservation scheme (a "water fund"). We apply an integrated modelling framework, building on previous field-based and modelling studies in the basin, and link biophysical outputs to economic benefits for the main actors in the basin. The first step in the modelling workflow is the use of a high-resolution spatial prioritization tool (Resource Investment Optimization System -- RIOS) to allocate the type and location of conservation investments in the different subbasins, subject to budget constraints and stakeholder concerns. We then run the Soil and Water Assessment Tool (SWAT) using the RIOS-identified investment scenarios to produce spatially explicit scenarios that simulate changes in water yield and suspended sediment. Finally, in close collaboration with downstream water users (urban water supply and hydropower) we link those biophysical outputs to monetary metrics, including: reduced water treatment costs, increased hydropower production, and crop yield benefits for upstream farmers in the conservation area. We explore how different budgets and different spatial targeting scenarios influence the return of the investments and the effectiveness of the water fund scheme. This study is novel in that it presents an integrated analysis targeting interventions in a decision context that takes into account local environmental and socio-economic conditions, and then relies on detailed, process-based, biophysical models to demonstrate the economic return on those investments. We conclude that the approach allows for an analysis on different spatial and temporal scales, providing conclusive evidence to stakeholders and decision makers on the contribution and benefits of the land-based investments in this basin. This is serving as foundational work to support the implementation of the Upper Tana-Nairobi Water Fund

  8. Conservation and Use of Genetic Resources of Underutilized Crops in the Americas—A Continental Analysis

    Directory of Open Access Journals (Sweden)

    Gea Galluzzi

    2014-02-01

    Full Text Available Latin America is home to dramatically diverse agroecological regions which harbor a high concentration of underutilized plant species, whose genetic resources hold the potential to address challenges such as sustainable agricultural development, food security and sovereignty, and climate change. This paper examines the status of an expert-informed list of underutilized crops in Latin America and analyses how the most common features of underuse apply to these. The analysis pays special attention to if and how existing international policy and legal frameworks on biodiversity and plant genetic resources effectively support or not the conservation and sustainable use of underutilized crops. Results show that not all minor crops are affected by the same degree of neglect, and that the aspects under which any crop is underutilized vary greatly, calling for specific analyses and interventions. We also show that current international policy and legal instruments have so far provided limited stimulus and funding for the conservation and sustainable use of the genetic resources of these crops. Finally, the paper proposes an analytical framework for identifying and evaluating a crop’s underutilization, in order to define the most appropriate type and levels of intervention (international, national, local for improving its status.

  9. In Vivo Enhancer Analysis Chromosome 16 Conserved NoncodingSequences

    Energy Technology Data Exchange (ETDEWEB)

    Pennacchio, Len A.; Ahituv, Nadav; Moses, Alan M.; Nobrega,Marcelo; Prabhakar, Shyam; Shoukry, Malak; Minovitsky, Simon; Visel,Axel; Dubchak, Inna; Holt, Amy; Lewis, Keith D.; Plajzer-Frick, Ingrid; Akiyama, Jennifer; De Val, Sarah; Afzal, Veena; Black, Brian L.; Couronne, Olivier; Eisen, Michael B.; Rubin, Edward M.

    2006-02-01

    The identification of enhancers with predicted specificitiesin vertebrate genomes remains a significant challenge that is hampered bya lack of experimentally validated training sets. In this study, weleveraged extreme evolutionary sequence conservation as a filter toidentify putative gene regulatory elements and characterized the in vivoenhancer activity of human-fish conserved and ultraconserved1 noncodingelements on human chromosome 16 as well as such elements from elsewherein the genome. We initially tested 165 of these extremely conservedsequences in a transgenic mouse enhancer assay and observed that 48percent (79/165) functioned reproducibly as tissue-specific enhancers ofgene expression at embryonic day 11.5. While driving expression in abroad range of anatomical structures in the embryo, the majority of the79 enhancers drove expression in various regions of the developingnervous system. Studying a set of DNA elements that specifically droveforebrain expression, we identified DNA signatures specifically enrichedin these elements and used these parameters to rank all ~;3,400human-fugu conserved noncoding elements in the human genome. The testingof the top predictions in transgenic mice resulted in a three-foldenrichment for sequences with forebrain enhancer activity. These datadramatically expand the catalogue of in vivo-characterized human geneenhancers and illustrate the future utility of such training sets for avariety of iological applications including decoding the regulatoryvocabulary of the human genome.

  10. Conserving energy in new buildings: analysis of nonregulatory policies

    Energy Technology Data Exchange (ETDEWEB)

    Scheer, R.M.; Nieves, L.A.; Mazzucchi, R.P.

    1981-05-01

    The costs and effectiveness of non-regulatory options relative to those of a regulatory approach are analyzed. Nonregulatory program alternatives identified are: information and education programs, tax incentives and disincentives, and mortage and finance programs. Chapter 2 briefly reviews survey data to assess present public awareness of energy issues and energy-efficient building design. Homebuyer and homebuilder surveys are reviewed and conservation motivations are discussed. Chapter 3 examines the provision of technical and economic information to various factors affecting building design decisions. This approach assumes that the economic incentives and technical means to achieve energy conservation goals already exist but that critical information is lacking. Chapter 4 examines how adjustments to the tax structure could enhance economic incentives and counter economic disincentives for energy conservation. Qualifying buildings for tax benefits would almost certainly require certification of design energy consumption. The effectiveness of tax incentives would depend in part on dissemination of public information regarding the incentives. Chapter 5 examines subsidies, such as subsidized mortgages and loan guarantees, which lower the cost of money or other costs but do not change the market structure facing the consumer. Certification that buildings qualify for such treatment would probably be required. Chapter 6 presents recommendations based on the study's findings. (MCW)

  11. National Head Start Association Position Paper: Why Conservatives Should Support Head Start.

    Science.gov (United States)

    Allen, Ben; Greene, Sarah; McGrady, Michael; Boel, Bridget; Ryan, Joel; Whitehead, Diane; Smith, Angela; Kane, Elizabeth; Qualls, Brocklin; Wahid, Kahree

    Head Start is a comprehensive federal preschool program, serving children prenatal through age 5 and their families with the overall goal of increasing the school readiness of young children in low-income families. Noting that the program has typically garnered strong support from political liberals and moderates, this position paper of the…

  12. Chromosome banding and gene localizations support extensive conservation of chromosome structure between cattle and sheep.

    Science.gov (United States)

    Hediger, R; Ansari, H A; Stranzinger, G F

    1991-01-01

    By using three gene probes, one derived from the porcine major histocompatibility complex (MHC) and two from bovine cytokeratin genes, type I (KRTA) and type II (KRTB), the hypothesis of conservation of genome structure in two members of the family Bovidae was examined. Gene mapping data revealed the MHC to be in chromosome region 23q15----q23 in cattle (BOLA) and 20q15----q23 in sheep (OLA). KRTA was localized to chromosome region 19q25----q29 in cattle and 11q25----q29 in sheep and KRTB to 5q14----q22 in cattle and 3q14----q22 in sheep. The banding patterns of the chromosome arms to which the loci were assigned were identical in both species. Moreover, the resemblances of GTG- or QFQ-banding patterns between the cattle and sheep karyotypes illustrated further chromosome homologies. These studies, based on gene mapping comparisons and comparative cytogenetics, document that within bovid chromosomes, homology of banding patterns corresponds to a homologous genetic structure. Hence, we propose that gene assignments on identified chromosomal segments in one species of the Bovidae can be extrapolated, in general, to other bovid species based on the banding homologies presented here.

  13. Credit of ecological interactions: A new conceptual framework to support conservation in a defaunated world.

    Science.gov (United States)

    Genes, Luísa; Cid, Bruno; Fernandez, Fernando A S; Pires, Alexandra S

    2017-03-01

    As defaunation spreads through the world, there is an urgent need for restoring ecological interactions, thus assuring ecosystem processes. Here, we define the new concept of credit of ecological interactions, as the number of interactions that can be restored in a focal area by species colonization or reintroduction. We also define rewiring time, as the time span until all the links that build the credit of ecological interactions of a focal area have become functional again. We expect that the credit will be gradually cashed following refaunation in rates that are proportional to (1) the abundance of the reintroduced species (that is expected to increase in time since release), (2) the abundance of the local species that interact with them, and (3) the traits of reintroduced species. We illustrated this approach using a theoretical model and an empirical case study where the credit of ecological interactions was estimated. This new conceptual framework is useful for setting reintroduction priorities and for evaluating the success of conservation initiatives that aim to restore ecosystem services.

  14. Analysis of the dance of native Isan artists for conservation

    Directory of Open Access Journals (Sweden)

    Pakawat Petatano

    2015-11-01

    Full Text Available This is a qualitative investigation to analyse native dance in North-eastern Thailand. There were three objectives for this investigation, which were to study the history of Isan folk dance, current dance postures and ways to conserve the current dance postures of Isan folk artists. Research tools were interview, observation, participation, focus group discussion and workshop. The purposively selected research sample was composed of 3 groups of national artists. The findings show that Isan folk dancer shave their own unique dancing styles. Each artist has his or her own identity, which is constructed based on personal experience of dancing and singing. Mor lam is a dance used to accompany traditional Isansung poetry. Modern dance postures have been adapted from the traditional forms. Dance postures have been adapted from three primary sources: traditional literature, the ethnic and Lanchang dancing in the Lao People’s Democratic Republic and rhythmic Khon Kaen compositions. The conclusions of this investigation suggest that preservation of the dancing arts and postures should centre on the incorporation of new knowledge, as well as the continuation of traditional dance postures. Further research is required for people interested in performing arts conservation in other provinces and other traditional performing arts.

  15. 78 FR 13563 - Energy Conservation Program: Availability of the Preliminary Technical Support Document for...

    Science.gov (United States)

    2013-02-28

    ...) analyses, and the national impact analysis (NIA); the methods for conducting them; and the relationship..., technology shifts, and rare earth phosphors. \\4\\ The framework document and public meeting information are... section IV Public Participation for webinar registration information, participant instructions,...

  16. Supporting Red List threat assessments with GeoCAT: geospatial conservation assessment tool

    Directory of Open Access Journals (Sweden)

    Steven Bachman

    2011-11-01

    Full Text Available GeoCAT is an open source, browser based tool that performs rapid geospatial analysis to ease the process of Red Listing taxa. Developed to utilise spatially referenced primary occurrence data, the analysis focuses on two aspects of the geographic range of a taxon: the extent of occurrence (EOO and the area of occupancy (AOO. These metrics form part of the IUCN Red List categories and criteria and have often proved challenging to obtain in an accurate, consistent and repeatable way. Within a familiar Google Maps environment, GeoCAT users can quickly and easily combine data from multiple sources such as GBIF, Flickr and Scratchpads as well as user generated occurrence data. Analysis is done with the click of a button and is visualised instantly, providing an indication of the Red List threat rating, subject to meeting the full requirements of the criteria. Outputs including the results, data and parameters used for analysis are stored in a GeoCAT file that can be easily reloaded or shared with collaborators. GeoCAT is a first step toward automating the data handling process of Red List assessing and provides a valuable hub from which further developments and enhancements can be spawned.

  17. Ways forward for aquatic conservation: Applications of environmental psychology to support management objectives.

    Science.gov (United States)

    Walker-Springett, Kate; Jefferson, Rebecca; Böck, Kerstin; Breckwoldt, Annette; Comby, Emeline; Cottet, Marylise; Hübner, Gundula; Le Lay, Yves-François; Shaw, Sylvie; Wyles, Kayleigh

    2016-01-15

    The success or failure of environmental management goals can be partially attributed to the support for such goals from the public. Despite this, environmental management is still dominated by a natural science approach with little input from disciplines that are concerned with the relationship between humans and the natural environment such as environmental psychology. Within the marine and freshwater environments, this is particularly concerning given the cultural and aesthetic significance of these environments to the public, coupled with the services delivered by freshwater and marine ecosystems, and the vulnerability of aquatic ecosystems to human-driven environmental perturbations. This paper documents nine case studies which use environmental psychology methods to support a range of aquatic management goals. Examples include understanding the drivers of public attitudes towards ecologically important but uncharismatic river species, impacts of marine litter on human well-being, efficacy of small-scale governance of tropical marine fisheries and the role of media in shaping attitudes towards. These case studies illustrate how environmental psychology and natural sciences can be used together to apply an interdisciplinary approach to the management of aquatic environments. Such an approach that actively takes into account the range of issues surrounding aquatic environment management is more likely to result in successful outcomes, from both human and environmental perspectives. Furthermore, the results illustrate that better understanding the societal importance of aquatic ecosystems can reduce conflict between social needs and ecological objectives, and help improve the governance of aquatic ecosystems. Thus, this paper concludes that an effective relationship between academics and practitioners requires fully utilising the skills, knowledge and experience from both sectors.

  18. The value of avitourism for conservation and job creation-An analysis from South Africa

    Directory of Open Access Journals (Sweden)

    Duan Biggs

    2011-01-01

    Full Text Available Tourism directed at bird watching (avitourism has become increasingly popular. In many lower and middle-income countries, including South Africa, avitourism is being applied in an effort to simultaneously achieve community development and biodiversity conservation. This paper presents the results of an exploratory investigation of 11 community-based avitourism projects in South Africa. Conservation benefits were measured with the Threat Reduction Assessment tool. We calculated the Gamma (G correlation coefficient to explore the relationship between conservation and income benefits and project characteristics. The projects were successful at reducing threats to sites where conservation was an explicit objective (n=11, G=0.609, P=0.03. The level of income benefits did not correlate with success in reducing threats to conservation. Once involved in avitourism projects, the average monthly income earned by local bird guides increased from USD 114 to USD 362. The extent of income benefits was positively related to the extent of support to projects (n=10, G=0.714, P=0.01. Participants in the projects reported substantive capacity building and empowerment benefits. Success in delivering conservation, income and empowerment benefits was challenged by the local guide′s limited previous exposure to tourism and business, the guide′s lack of self assurance, cultural differences, and a requirement for sustained mentorship and support to overcome these barriers. We conclude that with adequate long-term support, avitourism projects can be a cost-effective way to create jobs and deliver conservation and human development benefits.

  19. Analysing biodiversity and conservation knowledge products to support regional environmental assessments.

    Science.gov (United States)

    Brooks, Thomas M; Akçakaya, H Resit; Burgess, Neil D; Butchart, Stuart H M; Hilton-Taylor, Craig; Hoffmann, Michael; Juffe-Bignoli, Diego; Kingston, Naomi; MacSharry, Brian; Parr, Mike; Perianin, Laurence; Regan, Eugenie C; Rodrigues, Ana S L; Rondinini, Carlo; Shennan-Farpon, Yara; Young, Bruce E

    2016-02-16

    Two processes for regional environmental assessment are currently underway: the Global Environment Outlook (GEO) and Intergovernmental Platform on Biodiversity and Ecosystem Services (IPBES). Both face constraints of data, time, capacity, and resources. To support these assessments, we disaggregate three global knowledge products according to their regions and subregions. These products are: The IUCN Red List of Threatened Species, Key Biodiversity Areas (specifically Important Bird &Biodiversity Areas [IBAs], and Alliance for Zero Extinction [AZE] sites), and Protected Planet. We present fourteen Data citations: numbers of species occurring and percentages threatened; numbers of endemics and percentages threatened; downscaled Red List Indices for mammals, birds, and amphibians; numbers, mean sizes, and percentage coverages of IBAs and AZE sites; percentage coverage of land and sea by protected areas; and trends in percentages of IBAs and AZE sites wholly covered by protected areas. These data will inform the regional/subregional assessment chapters on the status of biodiversity, drivers of its decline, and institutional responses, and greatly facilitate comparability and consistency between the different regional/subregional assessments.

  20. SynBlast: Assisting the analysis of conserved synteny information

    Directory of Open Access Journals (Sweden)

    Stadler Peter F

    2008-08-01

    Full Text Available Abstract Motivation In the last years more than 20 vertebrate genomes have been sequenced, and the rate at which genomic DNA information becomes available is rapidly accelerating. Gene duplication and gene loss events inherently limit the accuracy of orthology detection based on sequence similarity alone. Fully automated methods for orthology annotation do exist but often fail to identify individual members in cases of large gene families, or to distinguish missing data from traceable gene losses. This situation can be improved in many cases by including conserved synteny information. Results Here we present the SynBlast pipeline that is designed to construct and evaluate local synteny information. SynBlast uses the genomic region around a focal reference gene to retrieve candidates for homologous regions from a collection of target genomes and ranks them in accord with the available evidence for homology. The pipeline is intended as a tool to aid high quality manual annotation in particular in those cases where automatic procedures fail. We demonstrate how SynBlast is applied to retrieving orthologous and paralogous clusters using the vertebrate Hox and ParaHox clusters as examples. Software The SynBlast package written in Perl is available under the GNU General Public License at http://www.bioinf.uni-leipzig.de/Software/SynBlast/.

  1. Error Analysis of Explicit Partitioned Runge–Kutta Schemes for Conservation Laws

    KAUST Repository

    Hundsdorfer, Willem

    2014-08-27

    An error analysis is presented for explicit partitioned Runge–Kutta methods and multirate methods applied to conservation laws. The interfaces, across which different methods or time steps are used, lead to order reduction of the schemes. Along with cell-based decompositions, also flux-based decompositions are studied. In the latter case mass conservation is guaranteed, but it will be seen that the accuracy may deteriorate.

  2. Space Launch System Vibration Analysis Support

    Science.gov (United States)

    Johnson, Katie

    2016-01-01

    The ultimate goal for my efforts during this internship was to help prepare for the Space Launch System (SLS) integrated modal test (IMT) with Rodney Rocha. In 2018, the Structural Engineering Loads and Dynamics Team will have 10 days to perform the IMT on the SLS Integrated Launch Vehicle. After that 10 day period, we will have about two months to analyze the test data and determine whether the integrated vehicle modes/frequencies are adequate for launching the vehicle. Because of the time constraints, NASA must have newly developed post-test analysis methods proven well and with technical confidence before testing. NASA civil servants along with help from rotational interns are working with novel techniques developed and applied external to Johnson Space Center (JSC) to uncover issues in applying this technique to much larger scales than ever before. We intend to use modal decoupling methods to separate the entangled vibrations coming from the SLS and its support structure during the IMT. This new approach is still under development. The primary goal of my internship was to learn the basics of structural dynamics and physical vibrations. I was able to accomplish this by working on two experimental test set ups, the Simple Beam and TAURUS-T, and by doing some light analytical and post-processing work. Within the Simple Beam project, my role involves changing the data acquisition system, reconfiguration of the test set up, transducer calibration, data collection, data file recovery, and post-processing analysis. Within the TAURUS-T project, my duties included cataloging and removing the 30+ triaxial accelerometers, coordinating the removal of the structure from the current rolling cart to a sturdy billet for further testing, preparing the accelerometers for remounting, accurately calibrating, mounting, and mapping of all accelerometer channels, and some testing. Hammer and shaker tests will be performed to easily visualize mode shapes at low frequencies. Short

  3. A SWOT analysis of Planning Support Systems

    NARCIS (Netherlands)

    Vonk, G.; Geertman, S.; Schot, P.P.

    2007-01-01

    Insight into the strengths, weaknesses, opportunities, and threats (SWOT) of planning support systems (PSS) is fragmented between users and system developers. The lack of combined insights blocks development in the right direction and makes potential users hesitant to apply PSS in planning. This stu

  4. A Lexical Analysis Tool with Ambiguity Support

    CERN Document Server

    Quesada, Luis; Cortijo, Francisco J

    2012-01-01

    Lexical ambiguities naturally arise in languages. We present Lamb, a lexical analyzer that produces a lexical analysis graph describing all the possible sequences of tokens that can be found within the input string. Parsers can process such lexical analysis graphs and discard any sequence of tokens that does not produce a valid syntactic sentence, therefore performing, together with Lamb, a context-sensitive lexical analysis in lexically-ambiguous language specifications.

  5. Status Quo, Analysis and Suggestions for Public Awareness on Wetland Conservation in China

    Institute of Scientific and Technical Information of China (English)

    ZHANG Xiaoyun; XU Jiliang; YUAN Jun

    2011-01-01

    To understand the status of public awareness on wetland conservation in China, 1 237 people from 8 provinces or municipality were interviewed by questionnaire. After analysis of the results, 88.5% of the interviewees know the word ‘wetland'. TV and radio is the main tool for them to get information. More than two thirds of the respondents mainly learn the information on wetland conservation through TV and radio. There are still big gaps among different people in understanding wetland. Only 13.3% of the respondents give a completely right answer on question ‘ which areas are wetlands'. Most of the respondents cited lakes, marshes and rivers as wetlands, but more than half of them do not regard beaches, reservoirs, paddy fields and fish ponds as wetlands. Most of the people cited wetlands can provide such functions as water conservation, climate regulation, protecting wildlife, removing pollution, but know little about other functions such as flood control, provisioning of aquatic products, and soil retention, and much less about the cultural functions such as recreation, and inherited folk culture. Except for wastewater discharge, nearly half of the general public knows little about other threats of the wetland, while most of the people do not believe that artificial aquaculture will cause threats to the wetland areas. Public awareness on wetland conservation in China needs to be improved. Most of the respondents cited that TV, radio and internet are the most effective ways to publicize information on wetland conservation. More than two thirds of the respondents mainly learn the information on wetland conservation through TV and radio, while 38.0% of the respondents mainly through internet.Specifically, for farmers/fishermen, posters/picture albums can benefit them more than the internet; the undergraduates also expect to learn wetland mainly through posters/picture albums; while for the primary and middle school students, the school education is another

  6. A gap analysis and comprehensive conservation strategy for riverine ecosystems of Missouri

    Science.gov (United States)

    Sowa, Scott P.; Annis, Gust; Morey, Michael E.; Diamond, David D.

    2007-01-01

    North America harbors an astounding proportion of the world's freshwater species, but it is facing a freshwater biodiversity crisis. A first step to slowing the loss of biodiversity involves identifying gaps in existing efforts to conserve biodiversity and prioritizing opportunities to fill these gaps. In this monograph we detail two separate, but complementary, conservation planning efforts - a Gap Analysis (GAP) and a State Wildlife Action Plan (WAP) - for Missouri that address this first step. The goal of the Missouri Aquatic GAP Project was to identify riverine ecosystems, habitats, and species not adequately represented (i.e., gaps) within existing conservation lands. The goal of the freshwater component of the Missouri Wildlife Action Plan was to identify and map a set of conservation-opportunity areas (COAs) that holistically represent all riverine ecosystems, habitats, and species in Missouri. Since conservation planning is a geographical exercise, both efforts utilized geographic information systems (GIS). Four principal GIS data sets were used in each planning effort: (1) a hierarchical riverine ecosystem classification, (2) predicted species distributions, (3) public ownership/stewardship, and (4) a human-threat index. Results of the gap analyses are not encouraging. Forty five, mostly rare, threatened, or endangered, species are not represented in lands set aside for conserving biodiversity. Results also illustrate the fragmented nature of conservation lands, which are mainly situated in the uplands and fail to provide connectivity among riverine habitats. Furthermore, many conservation lands are severely threatened by an array of human disturbances. In contrast, results of the WAP provide hope that relatively intact riverine ecosystems still exist. A total of 158 COAs, representing ∼6% of the total kilometers of stream in Missouri, were selected for the WAP. This illustrates that a wide spectrum of biodiversity can be represented within a small

  7. Bird diversity, birdwatching tourism and conservation in Peru: a geographic analysis.

    Science.gov (United States)

    Puhakka, Liisa; Salo, Matti; Sääksjärvi, Ilari E

    2011-01-01

    In the face of the continuing global biodiversity loss, it is important not only to assess the need for conservation, through e.g. gap analyses, but also to seek practical solutions for protecting biodiversity. Environmentally and socially sustainable tourism can be one such solution. We present a method to spatially link data on conservation needs and tourism-based economic opportunities, using bird-related tourism in Peru as an example. Our analysis highlighted areas in Peru where potential for such projects could be particularly high. Several areas within the central and northern Andean regions, as well as within the lowland Amazonian regions of Madre de Dios and Loreto emerge as promising for this type of activity. Mechanisms to implement conservation in these areas include e.g. conservation and ecotourism concessions, private conservation areas, and conservation easements. Some of these mechanisms also offer opportunities for local communities seeking to secure their traditional land ownership and use rights. (Spanish language abstract, Abstract S1).

  8. FPU-Supported Running Error Analysis

    OpenAIRE

    T. Zahradnický; R. Lórencz

    2010-01-01

    A-posteriori forward rounding error analyses tend to give sharper error estimates than a-priori ones, as they use actual data quantities. One of such a-posteriori analysis – running error analysis – uses expressions consisting of two parts; one generates the error and the other propagates input errors to the output. This paper suggests replacing the error generating term with an FPU-extracted rounding error estimate, which produces a sharper error bound.

  9. Sensitivity analysis of conservation opportunities in the irrigated agriculture sector of the Pacific Northwest

    Energy Technology Data Exchange (ETDEWEB)

    Harrer, B.J.

    1985-07-01

    This report summarizes the results of a sensitivity analysis of the cost effectiveness and energy-savings potential of conservation measures in the irrigation sector of the Pacific Northwest. This study examines the sensitivity of estimates of the cost effectiveness and energy-savings potential of conservation measures in the irrigation sector generated in a previous study (Harrer et al. 1985c) to changes in various types of input data parameters: reductions in purchase, installation and operating/maintenance costs for irrigation-sector conservation measures. Increases in the amounts of irrigation pumping head savings that would result from the use of the measures were also implemented in the sensitivity analysis. The assumptions used in the sensitivity analysis cause the analysis to represent a ''best-case'' scenario for the amount of energy that can potentially be saved through the implementation of irrigation-sector conservation measures in the Pacific Northwest and the costs per kWh saved for obtaining these savings. Under these ''best-case'' assumptions, it is estimated that approximately 207 average megawatts of electricity can potentially be saved by the year 2003 through the implementation of low-pressure irrigation, pump fittings redesign, increases in mainline size, and improved irrigation scheduling on new and existing irrigated acres. The majority of these savings (70%) can be obtained for a cost of 20 mills per kWh saved or less.

  10. Tool Supported Analysis of Web Services Protocols

    DEFF Research Database (Denmark)

    Marques, Abinoam P.; Ravn, Anders Peter; Srba, Jiri

    2011-01-01

    e.g. in the design of web services protocols, into an intermediate XML format. We further translate this format into a network of communicating state machines directly suitable for verification in the model checking tool UPPAAL. We introduce two types of communication media abstractions in order......We describe an abstract protocol model suitable for modelling of web services and other protocols communicating via unreliable, asynchronous communication channels. The model is supported by a tool chain where the first step translates tables with state/transition protocol descriptions, often used...... to ensure the finiteness of the protocol state-spaces while still being able to verify interesting protocol properties. The translations for different kinds of communication media have been implemented and successfully tested, among others, on agreement protocols from WS-Business Activity....

  11. Development of a cost-effective diversity-maximising decision-support tool for in situ crop genetic resources conservation

    DEFF Research Database (Denmark)

    Samuel, Aurelia F.; Drucker, Adam G.; Andersen, Sven Bode

    2013-01-01

    can be conserved based on a clustering of cacao species (Theobroma cacao L.). A conservation budget allocation model applied across a set of ten clusters and nine subclusters of cacao, together with the use of alternative diversity and risk measures, allowed for an evaluation of a range of potential...... conservation outcomes. Alternative risk measures generally resulted in the allocation of conservation funds to the same priority clusters of cacao (Criollo and Curaray). However, the use of the number of locally common alleles as an alternative to the original Weitzman diversity measure produced a markedly...

  12. Experiments in human multi-issue negotiation: analysis and support

    NARCIS (Netherlands)

    Bosse, T.; Jonker, C.M.; Schut, M.C.; Treur, J.

    2008-01-01

    The purpose of this paper is to report on experiments in (human) multi-issue negotiation and their analysis, and to present a generic software environment supporting such an analysis. First, the paper presents a System for Analysis of Multi-Issue Negotiation (SAMIN). SAMIN is designed to analyse neg

  13. Visualization and Analysis in Support of Fusion Science

    Energy Technology Data Exchange (ETDEWEB)

    Sanderson, Allen R. [Scientific Computing and Imaging Institute

    2012-10-01

    This report summarizes the results of the award for “Visualization and Analysis in Support of Fusion Science.” With this award our main efforts have been to develop and deploy visualization and analysis tools in three areas 1) magnetic field line analysis 2) query based visualization and 3) comparative visualization.

  14. Interactions between subunits of Saccharomyces cerevisiae RNase MRP support a conserved eukaryotic RNase P/MRP architecture.

    Science.gov (United States)

    Aspinall, Tanya V; Gordon, James M B; Bennett, Hayley J; Karahalios, Panagiotis; Bukowski, John-Paul; Walker, Scott C; Engelke, David R; Avis, Johanna M

    2007-01-01

    Ribonuclease MRP is an endonuclease, related to RNase P, which functions in eukaryotic pre-rRNA processing. In Saccharomyces cerevisiae, RNase MRP comprises an RNA subunit and ten proteins. To improve our understanding of subunit roles and enzyme architecture, we have examined protein-protein and protein-RNA interactions in vitro, complementing existing yeast two-hybrid data. In total, 31 direct protein-protein interactions were identified, each protein interacting with at least three others. Furthermore, seven proteins self-interact, four strongly, pointing to subunit multiplicity in the holoenzyme. Six protein subunits interact directly with MRP RNA and four with pre-rRNA. A comparative analysis with existing data for the yeast and human RNase P/MRP systems enables confident identification of Pop1p, Pop4p and Rpp1p as subunits that lie at the enzyme core, with probable addition of Pop5p and Pop3p. Rmp1p is confirmed as an integral subunit, presumably associating preferentially with RNase MRP, rather than RNase P, via interactions with Snm1p and MRP RNA. Snm1p and Rmp1p may act together to assist enzyme specificity, though roles in substrate binding are also indicated for Pop4p and Pop6p. The results provide further evidence of a conserved eukaryotic RNase P/MRP architecture and provide a strong basis for studies of enzyme assembly and subunit function.

  15. Molecular and biochemical analysis of rainbow trout LCK suggests a conserved mechanism for T-cell signaling in gnathostomes

    Science.gov (United States)

    Laing, K.J.; Dutton, S.; Hansen, J.D.

    2007-01-01

    Two genes were identified in rainbow trout that display high sequence identity to vertebrate Lck. Both of the trout Lck transcripts are associated with lymphoid tissues and were found to be highly expressed in IgM-negative lymphocytes. In vitro analysis of trout lymphocytes indicates that trout Lck mRNA is up-regulated by T-cell mitogens, supporting an evolutionarily conserved function for Lck in the signaling pathways of T-lymphocytes. Here, we describe the generation and characterization of a specific monoclonal antibody raised against the N-terminal domains of recombinant trout Lck that can recognize Lck protein(s) from trout thymocyte lysates that are similar in size (???57 kDa) to mammalian Lck. This antibody also reacted with permeabilized lymphocytes during FACS analysis, indicating its potential usage for cellular analyses of trout lymphocytes, thus representing an important tool for investigations of salmonid T-cell function.

  16. Hydrologic analysis for selection and placement of conservation practices at the watershed scale

    Science.gov (United States)

    Wilson, C.; Brooks, E. S.; Boll, J.

    2012-12-01

    When a water body is exceeding water quality standards and a Total Maximum Daily Load has been established, conservation practices in the watershed are able to reduce point and non-point source pollution. Hydrological analysis is needed to place conservation practices in the most hydrologically sensitive areas. The selection and placement of conservation practices, however, is challenging in ungauged watersheds with little or no data for the hydrological analysis. The objective of this research is to perform a hydrological analysis for mitigation of erosion and total phosphorus in a mixed land use watershed, and to select and place the conservation practices in the most sensitive areas. The study area is the Hangman Creek watershed in Idaho and Washington State, upstream of Long Lake (WA) reservoir, east of Spokane, WA. While the pollutant of concern is total phosphorus (TP), reductions in TP were translated to total suspended solids or reductions in nonpoint source erosion and sediment delivery to streams. Hydrological characterization was done with a simple web-based tool, which runs the Water Erosion Prediction Project (WEPP) model for representative land types in the watersheds, where a land type is defined as a unique combination of soil type, slope configuration, land use and management, and climate. The web-based tool used site-specific spatial and temporal data on land use, soil physical parameters, slope, and climate derived from readily available data sources and provided information on potential pollutant pathways (i.e. erosion, runoff, lateral flow, and percolation). Multiple land types representative in the watershed were ordered from most effective to least effective, and displayed spatially using GIS. The methodology for the Hangman Creek watershed was validated in the nearby Paradise Creek watershed that has long-term stream discharge and monitoring as well as land use data. Output from the web-based tool shows the potential reductions for different

  17. Propulsion Test Support Analysis with GPU Computing Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The design, development and staging of tests to certify liquid rocket engines usually require high-fidelity structural, fluid and thermal support analysis. These...

  18. Conservation analysis of dengue virust-cell epitope-based vaccine candidates using peptide block entropy

    DEFF Research Database (Denmark)

    Olsen, Lars Rønn; Zhang, Guang Lan; Keskin, Derin B.;

    2011-01-01

    Broad coverage of the pathogen population is particularly important when designing CD8+ T-cell epitope vaccines against viral pathogens. Traditional approaches are based on combinations of highly conserved T-cell epitopes. Peptide block entropy analysis is a novel approach for assembling sets...... residues. The block entropy analysis provides broad coverage of variant antigens. We applied the block entropy analysis method to the proteomes of the four serotypes of dengue virus (DENV) and found 1,551 blocks of 9-mer peptides, which cover 99% of available sequences with five or fewer unique peptides...

  19. Vibration Suppression Analysis for Supporter with Constrained Layer Damping

    Institute of Scientific and Technical Information of China (English)

    杜华军; 邹振祝; 黄文虎

    2004-01-01

    By analyzing the correlation between modal calculations and modal experiments of a typical supporter, an effective finite element analysis( FEA)model of the actual aerospace supporter is created. According to the analysis of constrained viscoelastic damping, the strategies of PVC have been worked out, and the correlation between modal calculations and modal experiments of the supporter has also been computed, and then, an experiment has been designed based on the calculation results. The results of experiments verify that the PVC strategy can effectively suppress vibration.

  20. Assessing community-based conservation projects: A systematic review and multilevel analysis of attitudinal, behavioral, ecological, and economic outcomes

    Directory of Open Access Journals (Sweden)

    Brooks Jeremy

    2013-01-01

    projects from previous reviews for a total of 136 projects. The analyses suggest that project design, particularly capacity building in local communities, is critical in generating success across all outcomes. In addition, some community characteristics, such as tenure regimes and supportive cultural beliefs and institutions, are important for some aspects of project success. Surprisingly, there is less evidence that national context systematically influences project outcomes. Conclusions Our study supports the idea that conservation projects should be carefully designed to be effective and that some characteristics of local communities can facilitate success. That well-designed projects can prevail over disadvantages relating to the pre-existing national and local context is encouraging. As the evidence base on CBC grows, it will be useful to repeat this analysis with additional search terms, and consider additional variables related to national context to further evaluate the role of broader socio-political and economic contexts.

  1. Data near processing support for climate data analysis

    Science.gov (United States)

    Kindermann, Stephan; Ehbrecht, Carsten; Hempelmann, Nils

    2016-04-01

    Climate data repositories grow in size exponentially. Scalable data near processing capabilities are required to meet future data analysis requirements and to replace current "data download and process at home" workflows and approaches. On one hand side, these processing capabilities should be accessible via standardized interfaces (e.g. OGC WPS), on the other side a large variety of processing tools, toolboxes and deployment alternatives have to be supported and maintained at the data/processing center. We present a community approach of a modular and flexible system supporting the development, deployment and maintenace of OGC-WPS based web processing services. This approach is organized in an open source github project (called "bird-house") supporting individual processing services ("birds", e.g. climate index calculations, model data ensemble calculations), which rely on basic common infrastructural components (e.g. installation and deployment recipes, analysis code dependencies management). To support easy deployment at data centers as well as home institutes (e.g. for testing and development) the system supports the management of the often very complex package dependency chain of climate data analysis packages as well as docker based packaging and installation. We present a concrete deployment scenario at the German Climate Computing Center (DKRZ). The DKRZ one hand side hosts a multi-petabyte climate archive which is integrated e.g. into the european ENES and worldwide ESGF data infrastructure, and on the other hand hosts an HPC center supporting (model) data production and data analysis. The deployment scenario also includes openstack based data cloud services to support data import and data distribution for bird-house based WPS web processing services. Current challenges for inter-institutionnal deployments of web processing services supporting the european and international climate modeling community as well as the climate impact community are highlighted

  2. Group Analysis of Nonlinear Internal Waves in Oceans. I: Self-adjointness, conservation laws, invariant solutions

    CERN Document Server

    Ibragimov, Nail H

    2011-01-01

    The paper is devoted to the group analysis of equations of motion of two-dimensional uniformly stratified rotating fluids used as a basic model in geophysical fluid dynamics. It is shown that the nonlinear equations in question have a remarkable property to be self-adjoint. This property is crucial for constructing conservation laws provided in the present paper. Invariant solutions are constructed using certain symmetries. The invariant solutions are used for defining internal wave beams.

  3. Cost-Effectiveness Analysis of the 2009 and 2012 IECC Residential Provisions – Technical Support Document

    Energy Technology Data Exchange (ETDEWEB)

    Mendon, Vrushali V.; Lucas, Robert G.; Goel, Supriya

    2012-12-04

    This analysis was conducted by Pacific Northwest National Laboratory (PNNL) in support of the U.S. Department of Energy’s (DOE) Building Energy Codes Program (BECP). DOE supports the development and adoption of efficient residential and commercial building energy codes. These codes set the minimum requirements for energy efficient building design and construction and ensure energy savings on a national level. This analysis focuses on one and two family dwellings, townhomes, and low-rise multifamily residential buildings. For these buildings, the basis of the energy codes is the International Energy Conservation Code (IECC). This report does not address commercial and high-rise residential buildings, which reference ANSI/ASHRAE/IES Standard 90.1.

  4. Threat to the point: improving the value of comparative extinction risk analysis for conservation action.

    Science.gov (United States)

    Murray, Kris A; Verde Arregoitia, Luis D; Davidson, Ana; Di Marco, Moreno; Di Fonzo, Martina M I

    2014-02-01

    Comparative extinction risk analysis is a common approach for assessing the relative plight of biodiversity and making conservation recommendations. However, the usefulness of such analyses for conservation practice has been questioned. One reason for underperformance may be that threats arising from global environmental changes (e.g., habitat loss, invasive species, climate change) are often overlooked, despite being widely regarded as proximal drivers of species' endangerment. We explore this problem by (i) reviewing the use of threats in this field and (ii) quantitatively investigating the effects of threat exclusion on the interpretation and potential application of extinction risk model results. We show that threat variables are routinely (59%) identified as significant predictors of extinction risk, yet while most studies (78%) include extrinsic factors of some kind (e.g., geographic or bioclimatic information), the majority (63%) do not include threats. Despite low overall usage, studies are increasingly employing threats to explain patterns of extinction risk. However, most continue to employ methods developed for the analysis of heritable traits (e.g., body size, fecundity), which may be poorly suited to the treatment of nonheritable predictors including threats. In our global mammal and continental amphibian extinction risk case studies, omitting threats reduced model predictive performance, but more importantly (i) reduced mechanistic information relevant to management; (ii) resulted in considerable disagreement in species classifications (12% and 5% for amphibians and mammals, respectively, translating to dozens and hundreds of species); and (iii) caused even greater disagreement (20-60%) in a downstream conservation application (species ranking). We conclude that the use of threats in comparative extinction risk analysis is important and increasing but currently in the early stages of development. Priorities for future studies include improving uptake

  5. Theoretical analysis of multiphase flow during oil-well drilling by a conservative model

    Science.gov (United States)

    Nicolas-Lopez, Ruben

    2005-11-01

    In order to decrease cost and improve drilling operations is necessary a better understood of the flow mechanisms. Therefore, it was carried out a multiphase conservative model that includes three mass equations and a momentum equation. Also, the measured geothermal gradient is utilized by state equations for estimating physical properties of the phases flowing. The mathematical model is solved by numerical conservative schemes. It is used to analyze the interaction among solid-liquid-gas phases. The circulating system consists as follow, the circulating fluid is pumped downward into the drilling pipe until the bottom of the open hole then it flows through the drill bit, and at this point formation cuttings are incorporated to the circulating fluid and carried upward to the surface. The mixture returns up to the surface by an annular flow area. The real operational conditions are fed to conservative model and the results are matched up to field measurements in several oil wells. Mainly, flow rates, drilling rate, well and tool geometries are data to estimate the profiles of pressure, mixture density, equivalent circulating density, gas fraction and solid carrying capacity. Even though the problem is very complex, the model describes, properly, the hydrodynamics of drilling techniques applied at oil fields. *Authors want to thank to Instituto Mexicano del Petroleo and Petroleos Mexicanos for supporting this research.

  6. Economic analysis of proposed voluntary energy conservation standard for new residential buildings

    Energy Technology Data Exchange (ETDEWEB)

    Marsh, S.J.; Roop, J.M.; Callaway, J.W.; Taylor, Z.T.

    1989-06-01

    The objective of this document is to present an analysis of the impacts of the proposed voluntary energy conservation standard for the construction of new residential buildings. This analysis examines the impacts of having the proposed residential standard apply immediately and, alternatively, having the proposed standard phased in over a five-year period. It does not address the question of whether realistically the standard would be adopted by states, nor does it weight the improbable impact of states with higher energy efficiency standards modifying their standard to comply with this voluntary standard. 19 refs., 1 fig., 12 tabs.

  7. Conservation priorities of useful plants from different techniques of collection and analysis of ethnobotanical data

    Directory of Open Access Journals (Sweden)

    Reinaldo F.P. de Lucena

    2013-03-01

    Full Text Available This study analyzes three methods of data analysis to verify which one would be more appropriate to get information aiming the conservation, selecting the use value (VU inventory in situ and conservation property index (IPC. It was developed in in Northeast Brazil, via interviewed householders (46 informants. The VU was calculated considering only the effective use of plants; the inventory in situ was made through the frequency of species occurrence in homes; and the IPC combining ethnobotanical and phytossociological data. It was observed a similar cast of the indicated species by VU and inventory in situ, being different from the IPC cast. As this study sought to analyze the best technique for species identification which were needing conservationist actions, and obtained different results among the chosen methods. It has been suggested the use of methods that unite in their analysis both ethnobotanical and ecological aspects, like in the plants list from the priority index of conservation, which demonstrated to be more efficient to identify rare species in the local vegetation. The VU and the inventory in situ are more efficient to identify the most known and used species in the communities, however without analyzing these plants in the local vegetation.

  8. Design and Analysis of Conservation Projects in Latin America: an Integrative Approach to Training

    Directory of Open Access Journals (Sweden)

    Carlos Galindo-Leal

    2002-01-01

    Full Text Available The Latin American countries have a disproportionate importance in global biodiversity conservation. Six of the 14 megadiversity countries that house 60–70% of the species in the world are located on this region. Unfortunately, the number of environmental professionals in Latin America is extremely small. Furthermore, most of them have no postgraduate degrees and are unacquainted with general research methodology and recently developed concepts and tools. In addition, many speak no English and have no way to communicate with colleagues in other parts of the world. In collaboration with Latin American colleagues, universities, government agencies, and nongovernment organizations, I have been developing an integrated field course titled "Design and Analyses of Projects to Manage Biological Diversity" to address these problems. To date, we have conducted nine courses in seven countries. The courses consist of five complementary components that are addressed sequentially: (1 conceptual framework, (2 critical analysis of personal projects, (3 methodological tools, (4 analytical tools, and (5 integration. I also discuss the elements that contribute to the success of these courses. Powerful elements in the course are the presentation, critical analysis, and constructive discussion of participants' real conservation projects. In addition, the careful matching of participants with instructors, subject matter, and learning environment has resulted in a great learning experience for everyone involved. Because of the lack of graduate training in conservation-related disciplines and the more general pitfalls associated with teaching science, there is a great demand in Latin America for integrated field courses.

  9. Development of Non-Conservative Joints in Beam Networks for Vibration Energy Flow Analysis

    Directory of Open Access Journals (Sweden)

    Jee-Hun Song

    2007-01-01

    Full Text Available Our work aims to find a general solution for the vibrational energy flow through a plane network of beams on the basis of an energy flow analysis. A joint between two semi-infinite beams are modeled by three sets of springs and dashpots. Thus, the results can incorporate the case of complaint and non-conservative in all the three degrees of freedom. In the cases of finite coupled structures connected at a certain angle, the derived non-conservative joints and developed wave energy equation were applied. The joint properties, the frequency, the coupling angle, and the internal loss factor were changed to evaluate the proposed methods for predicting medium-to-high frequency vibrational energy and intensity distributions.

  10. Risk Interfaces to Support Integrated Systems Analysis and Development

    Science.gov (United States)

    Mindock, Jennifer; Lumpkins, Sarah; Shelhamer, Mark; Anton, Wilma; Havenhill, Maria

    2016-01-01

    Objectives for systems analysis capability: Develop integrated understanding of how a complex human physiological-socio-technical mission system behaves in spaceflight. Why? Support development of integrated solutions that prevent unwanted outcomes (Implementable approaches to minimize mission resources(mass, power, crew time, etc.)); Support development of tools for autonomy (need for exploration) (Assess and maintain resilience -individuals, teams, integrated system). Output of this exercise: -Representation of interfaces based on Human System Risk Board (HSRB) Risk Summary information and simple status based on Human Research Roadmap; Consolidated HSRB information applied to support communication; Point-of-Departure for HRP Element planning; Ability to track and communicate status of collaborations. 4

  11. Zoos through the lens of the IUCN Red List: a global metapopulation approach to support conservation breeding programs.

    Science.gov (United States)

    Conde, Dalia A; Colchero, Fernando; Gusset, Markus; Pearce-Kelly, Paul; Byers, Onnie; Flesness, Nate; Browne, Robert K; Jones, Owen R

    2013-01-01

    Given current extinction trends, the number of species requiring conservation breeding programs (CBPs) is likely to increase dramatically. To inform CBP policies for threatened terrestrial vertebrates, we evaluated the number and representation of threatened vertebrate species on the IUCN Red List held in the ISIS zoo network and estimated the complexity of their management as metapopulations. Our results show that 695 of the 3,955 (23%) terrestrial vertebrate species in ISIS zoos are threatened. Only two of the 59 taxonomic orders show a higher proportion of threatened species in ISIS zoos than would be expected if species were selected at random. In addition, for most taxa, the management of a zoo metapopulation of more than 250 individuals will require the coordination of a cluster of 11 to 24 ISIS zoos within a radius of 2,000 km. Thus, in the zoo network, the representation of species that may require CBPs is currently low and the spatial distribution of these zoo populations makes management difficult. Although the zoo community may have the will and the logistical potential to contribute to conservation actions, including CBPs, to do so will require greater collaboration between zoos and other institutions, alongside the development of international agreements that facilitate cross-border movement of zoo animals. To maximize the effectiveness of integrated conservation actions that include CBPs, it is fundamental that the non-zoo conservation community acknowledges and integrates the expertise and facilities of zoos where it can be helpful.

  12. Zoos through the lens of the IUCN Red List: a global metapopulation approach to support conservation breeding programs.

    Directory of Open Access Journals (Sweden)

    Dalia A Conde

    Full Text Available Given current extinction trends, the number of species requiring conservation breeding programs (CBPs is likely to increase dramatically. To inform CBP policies for threatened terrestrial vertebrates, we evaluated the number and representation of threatened vertebrate species on the IUCN Red List held in the ISIS zoo network and estimated the complexity of their management as metapopulations. Our results show that 695 of the 3,955 (23% terrestrial vertebrate species in ISIS zoos are threatened. Only two of the 59 taxonomic orders show a higher proportion of threatened species in ISIS zoos than would be expected if species were selected at random. In addition, for most taxa, the management of a zoo metapopulation of more than 250 individuals will require the coordination of a cluster of 11 to 24 ISIS zoos within a radius of 2,000 km. Thus, in the zoo network, the representation of species that may require CBPs is currently low and the spatial distribution of these zoo populations makes management difficult. Although the zoo community may have the will and the logistical potential to contribute to conservation actions, including CBPs, to do so will require greater collaboration between zoos and other institutions, alongside the development of international agreements that facilitate cross-border movement of zoo animals. To maximize the effectiveness of integrated conservation actions that include CBPs, it is fundamental that the non-zoo conservation community acknowledges and integrates the expertise and facilities of zoos where it can be helpful.

  13. Zoos through the lens of the IUCN Red List: a global metapopulation approach to support conservation breeding programs

    DEFF Research Database (Denmark)

    Conde, Dalia Amor; Colchero, Fernando; Pearce-Kelly, Paul

    2013-01-01

    Given current extinction trends, the number of species requiring conservation breeding programs (CBPs) is likely to increase dramatically. To inform CBP policies for threatened terrestrial vertebrates, we evaluated the number and representation of threatened vertebrate species on the IUCN Red Lis...

  14. Design of Intelligent Network Performance Analysis Forecast Support System

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    A system designed for supporting the network performance analysis and forecast effort is pre sented, based on the combination of offline network analysis and online real-time performance forecast. The off-line analysis will perform analysis of specific network node performance, correlation analysis of relative network nodes performance and evolutionary mathematical modeling of long-term network performance mea surements. The online real-time network performance forecast will be based on one so-called hybrid predic tion modeling approach for short-term network performance prediction and trend analysis. Based on the module design, the system proposed has good intelligence, scalability and self-adaptability, which will offer highly effective network performance analysis and forecast tools for network managers, and is one ideal sup port platform for network performance analysis and forecast effort.

  15. An assessment of land conservation patterns in Maine based on spatial analysis of ecological and socioeconomic indicators.

    Science.gov (United States)

    Cronan, Christopher S; Lilieholm, Robert J; Tremblay, Jill; Glidden, Timothy

    2010-05-01

    Given the nature of modern conservation acquisitions, which often result from gifts and opportunistic purchases of full or partial property rights, there is a risk that the resulting mosaic of conserved resources may not represent a coherent set of public values and benefits. With different public and private entities engaged in land conservation, one would further expect that each organization would apply separate goals and criteria to the selection and acquisition of its conservation portfolio. This set of circumstances raises an important question: what is the aggregate outcome of this land conservation process? Retrospective assessments provide a means of reviewing cumulative historical decisions and elucidating lessons for improving future conservation strategies. This study used GIS-based spatial analysis to examine the relationships of private and public conservation lands in Maine to a variety of landscape metrics in order to determine the degree to which these lands represent core ecological and socioeconomic values that are meaningful to a wide cross-section of citizens. Results revealed that the gains of past conservation efforts in Maine are counter-balanced to some extent by apparent gaps in the existing fabric of conservation holdings. Conservation lands capture a representative sample of diverse habitat, provide a large measure of protection for multiple conservation values and indicators, and offer an unusual mix of outdoor recreational opportunities for residents and visitors alike. Yet, the majority of parcels are relatively small and isolated, and thus do not provide contiguous habitat blocks that offset ongoing processes of landscape fragmentation. Furthermore, the majority of area associated with many of the ecological metrics examined in this report is located outside the boundaries of current conservation holdings. The under-represented metrics identified in this investigation can be viewed as potential targets for new strategic conservation

  16. Development of output user interface software to support analysis

    Science.gov (United States)

    Wahanani, Nursinta Adi; Natsir, Khairina; Hartini, Entin

    2014-09-01

    Data processing software packages such as VSOP and MCNPX are softwares that has been scientifically proven and complete. The result of VSOP and MCNPX are huge and complex text files. In the analyze process, user need additional processing like Microsoft Excel to show informative result. This research develop an user interface software for output of VSOP and MCNPX. VSOP program output is used to support neutronic analysis and MCNPX program output is used to support burn-up analysis. Software development using iterative development methods which allow for revision and addition of features according to user needs. Processing time with this software 500 times faster than with conventional methods using Microsoft Excel. PYTHON is used as a programming language, because Python is available for all major operating systems: Windows, Linux/Unix, OS/2, Mac, Amiga, among others. Values that support neutronic analysis are k-eff, burn-up and mass Pu239 and Pu241. Burn-up analysis used the mass inventory values of actinide (Thorium, Plutonium, Neptunium and Uranium). Values are visualized in graphical shape to support analysis.

  17. Development of output user interface software to support analysis

    Energy Technology Data Exchange (ETDEWEB)

    Wahanani, Nursinta Adi, E-mail: sintaadi@batan.go.id; Natsir, Khairina, E-mail: sintaadi@batan.go.id; Hartini, Entin, E-mail: sintaadi@batan.go.id [Center for Development of Nuclear Informatics - National Nuclear Energy Agency, PUSPIPTEK, Serpong, Tangerang, Banten (Indonesia)

    2014-09-30

    Data processing software packages such as VSOP and MCNPX are softwares that has been scientifically proven and complete. The result of VSOP and MCNPX are huge and complex text files. In the analyze process, user need additional processing like Microsoft Excel to show informative result. This research develop an user interface software for output of VSOP and MCNPX. VSOP program output is used to support neutronic analysis and MCNPX program output is used to support burn-up analysis. Software development using iterative development methods which allow for revision and addition of features according to user needs. Processing time with this software 500 times faster than with conventional methods using Microsoft Excel. PYTHON is used as a programming language, because Python is available for all major operating systems: Windows, Linux/Unix, OS/2, Mac, Amiga, among others. Values that support neutronic analysis are k-eff, burn-up and mass Pu{sup 239} and Pu{sup 241}. Burn-up analysis used the mass inventory values of actinide (Thorium, Plutonium, Neptunium and Uranium). Values are visualized in graphical shape to support analysis.

  18. Process of consumer energy conservation: A conceptual framework for program analysis. Energy conservation programs for consumers: A comparative overview of findings

    Energy Technology Data Exchange (ETDEWEB)

    Joerges, B.; Olsen, M.E.; Mueller, H.

    1983-01-01

    In the first volume of the CECP Technical Reports Series two studies are combined: one version of the initial conceptual framework guiding CECP-research, and a condensed comparative analysis of the national findings in phase I of our research. Since the two papers originally stood on their own, some figures, tables, introductory remarks, and explications of terms are repeated. The first part, on the process of consumer energy conservation, is one of several formulations of a conceptual and analytical perspective for the evaluation of energy conservation policies and programs. The second part, on the comparison of conservation policies and programs, summarizes the findings of studies in the eight countries included. This cross-national overview should be understood as an attempt to identify common themes and trends as well as characteristic differences in conservation policies and programs directed at private end-users of energy. It should not be read as a substitute but rather an invitation to refer back to the original studies contained in this series.

  19. Seismic Analysis of Reinforced Concrete Shaft Support Water Storage Tank

    Directory of Open Access Journals (Sweden)

    Bharti Tekwani

    2016-05-01

    Full Text Available This paper compares the results of Seismic Analysis of Reinforced Concrete Shaft Support Water Storage Tank carried out in accordance with IS: 1893- 1984 and IS: 1893-2002 (Part-2 draft code. The analysis is carried out for shaft supported water tank of 500,750 and 1000 Cu.m capacity, located in four seismic zones (Zone-II, Zone -III, Zone-IV, Zone-V and on three different soil types (Hard rock, Medium soil, Soft soil. Further, 1000 kl tank for conditions - tank full, tank empty are also considered in this study. The analysis was performed using MAT LAB. The parameters of comparison include base shears, base moments and time history analysis. The above models are analyzed for different time history data such as El Centro, Kobe, Ji-Ji, Erzincan. The comparison is made between the structural responses of one mass and two mass models of above capacity.

  20. Cluster analysis of Pinus taiwanensis for its ex situ conservation in China.

    Science.gov (United States)

    Gao, X; Shi, L; Wu, Z

    2015-06-01

    Pinus taiwanensis Hayata is one of the most famous sights in the Huangshan Scenic Resort, China, because of its strong adaptability and ability to survive; however, this endemic species is currently under threat in China. Relationships between different P. taiwanensis populations have been well-documented; however, few studies have been conducted on how to protect this rare pine. In the present study, we propose the ex situ conservation of this species using geographical information system (GIS) cluster and genetic diversity analyses. The GIS cluster method was conducted as a preliminary analysis for establishing a sampling site category based on climatic factors. Genetic diversity was analyzed using morphological and genetic traits. By combining geographical information with genetic data, we demonstrate that growing conditions, morphological traits, and the genetic make-up of the population in the Huangshan Scenic Resort were most similar to conditions on Tianmu Mountain. Therefore, we suggest that Tianmu Mountain is the best choice for the ex situ conservation of P. taiwanensis. Our results provide a molecular basis for the sustainable management, utilization, and conservation of this species in Huangshan Scenic Resort.

  1. Large-scale analysis of conserved rare codon clusters suggests an involvement in co-translational molecular recognition events

    Science.gov (United States)

    Chartier, Matthieu; Gaudreault, Francis; Najmanovich, Rafael

    2012-01-01

    Motivation: An increasing amount of evidence from experimental and computational analysis suggests that rare codon clusters are functionally important for protein activity. Most of the studies on rare codon clusters were performed on a limited number of proteins or protein families. In the present study, we present the Sherlocc program and how it can be used for large scale protein family analysis of evolutionarily conserved rare codon clusters and their relation to protein function and structure. This large-scale analysis was performed using the whole Pfam database covering over 70% of the known protein sequence universe. Our program Sherlocc, detects statistically relevant conserved rare codon clusters and produces a user-friendly HTML output. Results: Statistically significant rare codon clusters were detected in a multitude of Pfam protein families. The most statistically significant rare codon clusters were predominantly identified in N-terminal Pfam families. Many of the longest rare codon clusters are found in membrane-related proteins which are required to interact with other proteins as part of their function, for example in targeting or insertion. We identified some cases where rare codon clusters can play a regulating role in the folding of catalytically important domains. Our results support the existence of a widespread functional role for rare codon clusters across species. Finally, we developed an online filter-based search interface that provides access to Sherlocc results for all Pfam families. Availability: The Sherlocc program and search interface are open access and are available at http://bcb.med.usherbrooke.ca Contact: rafael.najmanovich@usherbrooke.ca Supplementary information: Supplementary data are available at Bioinformatics online. PMID:22467916

  2. Analysis of federal options to support photovoltaic industry growth

    Energy Technology Data Exchange (ETDEWEB)

    Bennington, G.; Cherdak, A.; Williams, F.

    1979-05-01

    This report presents the methodology and results of an analysis to determine the impact and leverage of federal options for supporting the growth of the photovoltaic industry. Results were projected for combinations of the following: an aggressive federal research and development program, achievement of a technological breakthrough, and immediate or breakthrough-dependent incentives including direct price reductions, keyed-to-breakeven subsidies, and federal puchases. The modeling methodology and market assumptions were also tested to determine their effect on analysis results.

  3. Space system operations and support cost analysis using Markov chains

    Science.gov (United States)

    Unal, Resit; Dean, Edwin B.; Moore, Arlene A.; Fairbairn, Robert E.

    1990-01-01

    This paper evaluates the use of Markov chain process in probabilistic life cycle cost analysis and suggests further uses of the process as a design aid tool. A methodology is developed for estimating operations and support cost and expected life for reusable space transportation systems. Application of the methodology is demonstrated for the case of a hypothetical space transportation vehicle. A sensitivity analysis is carried out to explore the effects of uncertainty in key model inputs.

  4. Using Analysis of Governance to Unpack Community-Based Conservation: A Case Study from Tanzania.

    Science.gov (United States)

    Robinson, Lance W; Makupa, Enock

    2015-11-01

    Community-based conservation policies and programs are often hollow with little real devolution. But to pass a judgment of community-based or not community-based on such initiatives and programs obscures what is actually a suite of attributes. In this paper, we analyze governance around a specific case of what is nominally community-based conservation-Ikona Wildlife Management Area (WMA) in Tanzania-using two complementary sets of criteria. The first relates to governance "powers": planning powers, regulatory powers, spending powers, revenue-generating powers, and the power to enter into agreements. The second set of criteria derive from the understanding of governance as a set of social functions: social coordination, shaping power, setting direction, and building community. The analysis helps to detail ways in which the Tanzanian state through policy and regulations has constrained the potential for Ikona WMA to empower communities and community actors. Although it has some features of community-based conservation, community input into how the governance social functions would be carried out in the WMA was constrained from the start and is now largely out of community hands. The two governance powers that have any significant community-based flavor-spending powers and revenue-generating powers-relate to the WMA's tourism activities, but even here the picture is equivocal at best. The unpacking of governance that we have done, however, reveals that community empowerment through the processes associated with creating and recognizing indigenous and community-conserved areas is something that can be pursued through multiple channels, some of which might be more strategic than others.

  5. Strategic Analysis of Family Support in EHDI Systems

    Science.gov (United States)

    Bradham, Tamala S.; Houston, K. Todd; Guignard, Gayla Hutsell; Hoffman, Jeff

    2011-01-01

    State coordinators of early hearing detection and intervention (EHDI) programs completed a strengths, weaknesses, opportunities, and threats, or SWOT, analysis that examined 12 areas within state EHDI programs. For the family support area, 47 EHDI coordinators listed 255 items, and themes were identified within each category. A threats,…

  6. Position of the American Dietetic Association: food and nutrition professionals can implement practices to conserve natural resources and support ecological sustainability.

    Science.gov (United States)

    Harmon, Alison H; Gerald, Bonnie L

    2007-06-01

    It is the position of the American Dietetic Association to encourage environmentally responsible practices that conserve natural resources, minimize the quantity of waste generated, and support the ecological sustainability of the food system-the process of food production, transformation, distribution, access, and consumption. Registered dietitians and dietetic technicians, registered, play various roles in the food system and work in settings where efforts to conserve can have significant effects. Natural resources that provide the foundation for the food system include biodiversity, soil, land, energy, water, and air. A food system that degrades or depletes its resource base is not sustainable. Making wise food purchases and food management decisions entails understanding the external costs of food production and foodservice and how these external costs affect food system sustainability. This position paper provides information, specific action-oriented strategies, and resources to guide registered dietitians and dietetic technicians, registered, in food decision making and professional practice. Food and nutrition professionals also can participate in policy making at the local, state, and national levels, and can support policies that encourage the development of local sustainable food systems. Our actions today have global consequences. Conserving and protecting resources will contribute to the sustainability of the global food system now and in the future.

  7. Error analysis for momentum conservation in Atomic-Continuum Coupled Model

    Science.gov (United States)

    Yang, Yantao; Cui, Junzhi; Han, Tiansi

    2016-08-01

    Atomic-Continuum Coupled Model (ACCM) is a multiscale computation model proposed by Xiang et al. (in IOP conference series materials science and engineering, 2010), which is used to study and simulate dynamics and thermal-mechanical coupling behavior of crystal materials, especially metallic crystals. In this paper, we construct a set of interpolation basis functions for the common BCC and FCC lattices, respectively, implementing the computation of ACCM. Based on this interpolation approximation, we give a rigorous mathematical analysis of the error of momentum conservation equation introduced by ACCM, and derive a sequence of inequalities that bound the error. Numerical experiment is carried out to verify our result.

  8. Web system to support analysis of the Tile Calorimeter commissioning

    Science.gov (United States)

    Maidantchik, C.; Faria, A.; Grael, F. F.; Ferreira, F. G.; Galvão, K. K.; Dotti, A.; Solans, C.; Price, L.

    2008-07-01

    This article describes the set of computer systems that support the data analysis and quality control during the Tile Calorimeter commissioning phase. The Tile Commissioning Web System (TCWS) encapsulates the steps to retrieve information, execute programs, access the outcomes, register statements and verify the equipment status. TCWS integrates different applications, each one presenting a particular view of the commissioning process. The TileComm Analysis stores plots and analysis results, provides equipment-oriented visualization, collects information regarding the equipment performance, and outlines its status in each test. The Timeline application provides the equipment status history in a chronological way. The Web Interface for Shifters supports monitoring tasks by managing test parameters, graphical views of the detector's performance, and information status of all equipment that was used in each test. The DCS Web System provides a standard way to verify the behaviour of power sources and the cooling system.

  9. Models for residential- and commercial-sector energy-conservation analysis: applications, limitations, and future potential. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Cole, Henry E.; Fullen, Robert E.

    1980-09-01

    This report reviews four of the major models used by the Department of Energy (DOE) for energy conservation analyses in the residential- and commercial-building sectors. The objective is to provide a critical analysis of how these models can serve as tools for DOE and its Conservation Policy Office in evaluating and quantifying their policy and program requirements. For this, the study brings together information on the models' analytical structure and their strengths and limitations in policy applications these are then employed to assess the most-effective role for each model in addressing future issues of buildings energy-conservation policy and analysis. The four models covered are: Oak Ridge Residential Energy Model; Micro Analysis of Transfers to Households/Comprehensive Human Resources Data System (MATH/CHRDS) Model; Oak Ridge Commercial Energy Model; and Brookhaven Buildings Energy Conservation Optimization Model (BECOM).

  10. National-scale analysis for the identification of High Conservation Value Forests (HCVFs

    Directory of Open Access Journals (Sweden)

    Maesano M

    2011-02-01

    Full Text Available In Italy, forests cover about one third of the national territory. In recent years, sustainability has been applied to forest management through the introduction of the Sustainable Forest Management (SFM concept. Since the Rio Conference, several initiatives at international and governmental level aimed to realize the SFM concept by the establishment of a set of principles with general validity. One of the most successful initiatives is the Forest Stewardship Council (FSC, which has developed a system of voluntary certification specific for the forestry sector, as well as 10 principles and 56 criteria for good forest management. The concept of High Conservation Value Forest concept (HCVFs was defined in 1999 by FSC under Principle 9, and its application requires the identification of six categories of High Conservation Values (HCV. The aim of this study was to define the parameters for the HCVFs Italian forests, A first national mapping for the first level of High Conservation Value was developed focusing on protected areas, threatened and endangered species and the ecosystemic temporal use. Protected areas may constitute the basis of the SFM. This work is the result of data processing and distribution analysis through the intersection of vectorial data of national forests areas in ArcMap, on the basis of available information. Protected forest areas represent 34% of the national forest area. The different categories of protected areas contribute differently to protection, in particular the larger amount of preserved forests (22.96% falls within Sites of Community Importance (SCI. The analysis of highly protected forest types revealed major differences likely linked to site ecological conditions, which are extremely variable over the country. The HCVF concept is applied in the forest certification field and can be used in sustainable forest management, planning and land use, and policy commitments.

  11. The BsaHI restriction-modification system: Cloning, sequencing and analysis of conserved motifs

    Directory of Open Access Journals (Sweden)

    Roberts Richard J

    2008-05-01

    Full Text Available Abstract Background Restriction and modification enzymes typically recognise short DNA sequences of between two and eight bases in length. Understanding the mechanism of this recognition represents a significant challenge that we begin to address for the BsaHI restriction-modification system, which recognises the six base sequence GRCGYC. Results The DNA sequences of the genes for the BsaHI methyltransferase, bsaHIM, and restriction endonuclease, bsaHIR, have been determined (GenBank accession #EU386360, cloned and expressed in E. coli. Both the restriction endonuclease and methyltransferase enzymes share significant similarity with a group of 6 other enzymes comprising the restriction-modification systems HgiDI and HgiGI and the putative HindVP, NlaCORFDP, NpuORFC228P and SplZORFNP restriction-modification systems. A sequence alignment of these homologues shows that their amino acid sequences are largely conserved and highlights several motifs of interest. We target one such conserved motif, reading SPERRFD, at the C-terminal end of the bsaHIR gene. A mutational analysis of these amino acids indicates that the motif is crucial for enzymatic activity. Sequence alignment of the methyltransferase gene reveals a short motif within the target recognition domain that is conserved among enzymes recognising the same sequences. Thus, this motif may be used as a diagnostic tool to define the recognition sequences of the cytosine C5 methyltransferases. Conclusion We have cloned and sequenced the BsaHI restriction and modification enzymes. We have identified a region of the R. BsaHI enzyme that is crucial for its activity. Analysis of the amino acid sequence of the BsaHI methyltransferase enzyme led us to propose two new motifs that can be used in the diagnosis of the recognition sequence of the cytosine C5-methyltransferases.

  12. Classification using least squares support vector machine for reliability analysis

    Institute of Scientific and Technical Information of China (English)

    Zhi-wei GUO; Guang-chen BAI

    2009-01-01

    In order to improve the efficiency of the support vector machine (SVM) for classification to deal with a large amount of samples,the least squares support vector machine (LSSVM) for classification methods is introduced into the reliability analysis.To reduce the computational cost,the solution of the SVM is transformed from a quadratic programming to a group of linear equations.The numerical results indicate that the reliability method based on the LSSVM for classification has higher accuracy and requires less computational cost than the SVM method.

  13. Mobility analysis tool based on the fundamental principle of conservation of energy.

    Energy Technology Data Exchange (ETDEWEB)

    Spletzer, Barry Louis; Nho, Hyuchul C.; Salton, Jonathan Robert

    2007-08-01

    In the past decade, a great deal of effort has been focused in research and development of versatile robotic ground vehicles without understanding their performance in a particular operating environment. As the usage of robotic ground vehicles for intelligence applications increases, understanding mobility of the vehicles becomes critical to increase the probability of their successful operations. This paper describes a framework based on conservation of energy to predict the maximum mobility of robotic ground vehicles over general terrain. The basis of the prediction is the difference between traction capability and energy loss at the vehicle-terrain interface. The mission success of a robotic ground vehicle is primarily a function of mobility. Mobility of a vehicle is defined as the overall capability of a vehicle to move from place to place while retaining its ability to perform its primary mission. A mobility analysis tool based on the fundamental principle of conservation of energy is described in this document. The tool is a graphical user interface application. The mobility analysis tool has been developed at Sandia National Laboratories, Albuquerque, NM. The tool is at an initial stage of development. In the future, the tool will be expanded to include all vehicles and terrain types.

  14. A variational approach to the analysis of non-conservative mechatronic systems

    CERN Document Server

    Allison, A; Abbott, D

    2012-01-01

    We develop a method for systematically constructing Lagrangian functions for dissipative mechanical, electrical and, mechatronic systems. We derive the equations of motion for some typical mechatronic systems using deterministic principles that are strictly variational. We do not use any ad hoc features that are added on after the analysis has been completed, such as the Rayleigh dissipation function. We generalise the concept of potential, and define generalised potentials for dissipative lumped system elements. Our innovation offers a unified approach to the analysis of mechatronic systems where there are energy and power terms in both the mechanical and electrical parts of the system. Using our novel technique, we can take advantage of the analytic approach from mechanics, and we can apply these pow- erful analytical methods to electrical and to mechatronic systems. We can analyse systems that include non-conservative forces. Our methodology is deterministic and does does require any special intuition, and...

  15. Spatial Analysis of Conservation Priorities Based on Ecosystem Services in the Atlantic Forest Region of Misiones, Argentina

    Directory of Open Access Journals (Sweden)

    Matthew L. Clark

    2012-08-01

    Full Text Available Understanding the spatial pattern of ecosystem services is important for effective environmental policy and decision-making. In this study, we use a geospatial decision-support tool (Marxan to identify conservation priorities for habitat and a suite of ecosystem services (storage carbon, soil retention and water yield in the Upper Paraná Atlantic Forest from Misiones, Argentina—an area of global conservation priority. Using these results, we then evaluate the efficiency of existing protected areas in conserving both habitat and ecosystem services. Selected areas for conserving habitat had an overlap of carbon and soil ecosystem services. Yet, selected areas for water yield did not have this overlap. Furthermore, selected areas with relatively high overlap of ecosystem services tended to be inside protected areas; however, other important areas for ecosystem services (i.e., central highlands do not have legal protection, revealing the importance of enforcing existing environmental regulations in these areas.

  16. Analysis of conservativity analysis for clearance levels. Final report; Konservativitaetsanalysen bei Freigabegrenzwerten. Schlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Deckert, A.; Thierfeldt, S.

    1997-07-01

    When deriving clearance levels for material from nuclear installations it is necessary to proceed with a certain degree of conservativity. This can, however, differ between various sets of clearance levels leading to inconsistencies between clearance pathways. The aim of the work therefore is to compare levels of conservativity for the following two sets of clearance levels: clearance levels for disposal as conventional waste and for metallic materials for recycling/reuse. A method was developed to quantify the degree of conservativity and make it comparable. The actual and future situation for disposal of (conventional) wastes in Germany was analysed. In addition, the masses, nuclide vectors, geographical distribution etc. for slightly radioactive material being cleared for conventional disposal was analysed and modelled and the resulting dose distributions were calculated. The values for the clearance levels were taken from the 1995 recommendation by the German Commission on Radiation Protection (SSK). By using realistic scenarios, the exposure was calculated for the personnel on the landfills and for persons of the general public being exposed via groundwater pathways. It could be shown that the trivial dose range will not be exceeded even if the masses of cleared material per landfill site exceed 100 Mg/a. Because of the types and distribution of nuclear installations in Germany and because of the nuclide vectors it is therefore not necessary to limit the masses per landfill sites. Clearance levels that are determined by the exposure pathways external exposure to and the inhalation of dust by the landfill personnel show a similar level of conservativity as those for metal scrap (the reference). This means that the clearance levels for gamma emitting nuclides are not overly restrictive. The radiological model for the exposure via the groundwater pathway is much more conservative (concerning mainly beta emitting nuclides). Although radiologically justified

  17. State of the interface between conservation and physiology: a bibliometric analysis.

    Science.gov (United States)

    Lennox, Robert; Cooke, Steven J

    2014-01-01

    Contemporary conservation science benefits from the perspectives of a variety of different disciplines, including a recent synergy with physiology, an interface known as 'conservation physiology'. To evaluate the degree of interaction between conservation and animal/plant physiology, we conducted three bibliometric analyses. We first pursued the use of the term 'conservation physiology' since its first definition in 2006 to determine how frequently it has been used and in which publications. Secondly, we evaluated the occurrence of conservation terms in animal and plant physiology journals, physiological terms in conservation journals, and a combination of terms in ecology journals. Thirdly, we explored trends in a subset of conservation physiology articles published between 2006 and 2012. We identified a surge in the use of the term 'conservation physiology' in 2012, after only a slow increase in usage between 2006 and 2011. Conservation journals tend to have been significantly more active in publishing conservation physiology than animal physiology, plant physiology or ecology journals. However, we found evidence that ecology and animal physiology journals began to incorporate more conservation physiology after 2006, while conservation- and plant physiology-themed journals did not. Among 299 conservation physiology articles that we identified, vertebrate taxa have been over-represented in conservation physiology compared with their relative taxonomic abundance, invertebrate taxa have been under-represented, and plants have been represented in proportion to their relative taxonomic abundance; however, those findings are reasonably consistent with publication trends in conservation biology. Diffuse distribution of conservation physiology papers throughout the literature may have been a barrier to the growth of the subdiscipline when the interface was emerging. The introduction of the focused journal Conservation Physiology in 2013 may address that deficiency

  18. Design and Analysis of Muon Beam Stop Support Structures

    Energy Technology Data Exchange (ETDEWEB)

    Okafor, Udenna [Northern Illinois Univ., DeKalb, IL (United States)

    2015-01-01

    The primary objective of this thesis is to design and analyze support structures to be used in the installation, test and final positioning of the MBS throughout the life of the Mu2e experiment. There several requirements for the MBS imposed by both the scope of the experiment and, other components within the DS bore. The functions of the MBS are: 1. To limit the induced rates in the Tracker, the Calorimeter and the Cosmic Ray Veto due to backsplash-and-secondary interactions, and 2. To reduce radiation levels external to the Detector solenoid. The structures used in supporting the MBS will also adhere to requirements imposed by its functions. These requirements are critical to the support structures and affect design decisions. Other requirements critical to the design are imposed by the weight, positional tolerance and assembly procedure of the MBS, and also, the magnetic field and vacuum dose rate of the DS bore. A detailed breakdown of how each requirement affects the structural design can be found in chapter 2. Chapter 3 describes the design of each support structure and its attachment to the MBS while chapter 4 describes the results from structural analysis of the support structures. Chapter 5 describes evaluation for the design through testing and calculations while the conclusion in chapter 6 reports the current status at the time of this thesis submission with a plan for future work to be completed until final design and installation.

  19. Analysis of Advanced Respiratory Support Onboard ISS and CCV

    Science.gov (United States)

    Shah, Ronak V.; Kertsman, Eric L.; Alexander, David J.; Duchesne, Ted; Law, Jennifer; Roden, Sean K.

    2014-01-01

    NASA is collaborating with private entities for the development of commercial space vehicles. The Space and Clinical Operations Division was tasked to review the oxygen and respiratory support system and recommend what capabilities, if any, the vehicle should have to support the return of an ill or injured crewmember. The Integrated Medical Model (IMM) was utilized as a data source for the development of these recommendations. The Integrated Medical Model (IMM) was used to simulate a six month, six crew, International Space Station (ISS) mission. Three medical system scenarios were considered based on the availability of (1) oxygen only, (2) oxygen and a ventilator, or (3) neither oxygen nor ventilator. The IMM analysis provided probability estimates of medical events that would require either oxygen or ventilator support. It also provided estimates of crew health, the probability of evacuation, and the probability of loss of crew life secondary to medical events for each of the three medical system scenarios. These IMM outputs were used as objective data to enable evidence-based decisions regarding oxygen and respiratory support system requirements for commercial crew vehicles. The IMM provides data that may be utilized to support informed decisions regarding the development of medical systems for commercial crew vehicles.

  20. Prioritization of strategies for protected area management with local people using the hybrid SWOT-AHP analysis: the case of Kakum conservation area, Ghana

    Directory of Open Access Journals (Sweden)

    Raphael Foli Fiagbomeh

    2015-05-01

    Full Text Available The contribution of protected areas towards conservation and protection of biodiversity cannot be over emphasized. Likewise, the dependence of local communities on forest and natural resources cannot be overlooked. Hence for the long term viability of forest reserves and wildlife protected area, the relationship of local people living close to these areas are of key importance if conflict of use can be mitigated. Admittedly, decision-making with respect to forest resource use and protection are complex due to the multiple interests of the major stakeholders. Stakeholder involvement in the planning, management and policy analysis can help resolve conflicts, and increase the commitment of local people to support conservation of protected areas. In this paper, we employ the SWOT-AHP methodology, with the aid of the Priority Estimation Tool (PriEsT, to evaluate and prioritize three management strategies for the Kakum conservation area in Ghana, as a means to facilitate conservation while ensuring benefits to local people. Considering the management objectives of the conservation area, seventeen SWOT sub-factors were identified and used in rating the three alternative management strategies. Among the strength sub-factors, enforcement of protection regulations (S4 is the most important. Similarly, limited funds for patrolling and outreach programs (W3, local people’s interest in alternative livelihood (O4 and the presence of illegal activities (T3 are the most important weakness, opportunity and threat sub-factors respectively. The management strategy “institute village committees to support monitoring and protection of resources” (A1 has the highest priority rating, indicating that management authorities must pay more attention to collaborative management. We propose that to improve on protected area management in Ghana, more management strategy studies must be conducted. However, these studies may apply the fuzzy AHP technique since it is

  1. Water-quality assessment of the Lower Grand River Basin, Missouri and Iowa, USA, in support of integrated conservation practices

    Science.gov (United States)

    Wilkison, Donald H.; Armstrong, Daniel J.

    2016-01-01

    The effectiveness of agricultural conservation programmes to adequately reduce nutrient exports to receiving streams and to help limit downstream hypoxia issues remains a concern. Quantifying programme success can be difficult given that short-term basin changes may be masked by long-term water-quality shifts. We evaluated nutrient export at stream sites in the 44 months that followed a period of increased, integrated conservation implementation within the Lower Grand River Basin. These short-term responses were then compared with export that occurred in the main stem and adjacent rivers in northern Missouri over a 22-year period to better contextualize any recent changes. Results indicate that short-term (October 2010 through May 2014) total nitrogen (TN) concentrations in the Grand River were 20% less than the long-term average, and total phosphorus (TP) concentrations were 23% less. Nutrient reductions in the short term were primarily the result of the less-than-average precipitation and, consequently, streamflow that was 36% below normal. Therefore, nutrient concentrations measured in tributary streams were likely less than normal during the implementation period. Northern Missouri streamflow-normalized TN concentrations remained relatively flat or declined over the period 1991 through 2013 likely because available sources of nitrogen, determined as the sum of commercial fertilizers, available animal manures and atmospheric inputs, were typically less than crop requirement for much of that time frame. Conversely, flow-normalized stream TP concentrations increased over the past 22 years in northern Missouri streams, likely in response to many years of phosphorus inputs in excess of crop requirements. Stream nutrient changes were most pronounced during periods that coincided with the major tillage, planting and growth phases of row crops and increased streamflow. Nutrient reduction strategies targeted at the period February through June would likely have the

  2. Insular ecosystems of the southeastern United States—A regional synthesis to support biodiversity conservation in a changing climate

    Science.gov (United States)

    Cartwright, Jennifer M.; Wolfe, William J.

    2016-08-11

    In the southeastern United States, insular ecosystems—such as rock outcrops, depression wetlands, high-elevation balds, flood-scoured riparian corridors, and insular prairies and barrens—occupy a small fraction of land area but constitute an important source of regional and global biodiversity, including concentrations of rare and endemic plant taxa. Maintenance of this biodiversity depends upon regimes of abiotic stress and disturbance, incorporating factors such as soil surface temperature, widely fluctuating hydrologic conditions, fires, flood scouring, and episodic droughts that may be subject to alteration by climate change. Over several decades, numerous localized, site-level investigations have yielded important information about the floristics, physical environments, and ecological dynamics of these insular ecosystems; however, the literature from these investigations has generally remained fragmented. This report consists of literature syntheses for eight categories of insular ecosystems of the southeastern United States, concerning (1) physical geography, (2) ecological determinants of community structures including vegetation dynamics and regimes of abiotic stress and disturbance, (3) contributions to regional and global biodiversity, (4) historical and current anthropogenic threats and conservation approaches, and (5) key knowledge gaps relevant to conservation, particularly in terms of climate-change effects on biodiversity. This regional synthesis was undertaken to discern patterns across ecosystems, identify knowledge gaps, and lay the groundwork for future analyses of climate-change vulnerability. Findings from this synthesis indicate that, despite their importance to regional and global biodiversity, insular ecosystems of the southeastern United States have been subjected to a variety of direct and indirect human alterations. In many cases, important questions remain concerning key determinants of ecosystem function. In particular, few

  3. Analysis of Logistics in Support of a Human Lunar Outpost

    Science.gov (United States)

    Cirillo, William; Earle, Kevin; Goodliff, Kandyce; Reeves, j. D.; Andrashko, Mark; Merrill, R. Gabe; Stromgren, Chel

    2008-01-01

    Strategic level analysis of the integrated behavior of lunar transportation system and lunar surface system architecture options is performed to inform NASA Constellation Program senior management on the benefit, viability, affordability, and robustness of system design choices. This paper presents an overview of the approach used to perform the campaign (strategic) analysis, with an emphasis on the logistics modeling and the impacts of logistics resupply on campaign behavior. An overview of deterministic and probabilistic analysis approaches is provided, with a discussion of the importance of each approach to understanding the integrated system behavior. The logistics required to support lunar surface habitation are analyzed from both 'macro-logistics' and 'micro-logistics' perspectives, where macro-logistics focuses on the delivery of goods to a destination and micro-logistics focuses on local handling of re-supply goods at a destination. An example campaign is provided to tie the theories of campaign analysis to results generation capabilities.

  4. A prototype auto-human support system for spatial analysis

    Institute of Scientific and Technical Information of China (English)

    LI Lianfa; WANG Jinfeng

    2006-01-01

    Spatial analysis is a multidisciplinary field that involves multiple influential factors, variation and uncertainty, and modeling of geospatial data is a complex procedure affected by spatial context, mechanism and assumptions. In order to make spatial modeling easier, some scholars have suggested a lot of knowledge from exploratory data analysis (EDA), specification of the model, fitness and diagnosis of the model, to interpretation of the model. Also an amount of software has improved some functionalities of spatial analysis, e.g. EDA by the dynamic link (GeoDa) and robust statistical calculation (R). However, there are few programs for spatial analysis that can automatically deal with unstructured declarative issues and uncertainty in machine modeling using the domain knowledge. Under this context, this paper suggests a prototype support system for spatial analysis that can automatically use experience and knowledge from the experts to deal with complexity and uncertainty in modeling. The knowledge base component, as the major contribution of the system, in support of the expert system shell, codes and stores declarative modeling knowledge, e.g. spatial context, mechanisms and prior knowledge to deal with declarative issues during the modeling procedure. With the open architecture, the system integrates functionalities of other components, e.g. GIS' visualization, DBMS, and robust calculation in an interactive environment. An application case of spatial sampling, design and implementation of spatial modeling with such a system is demonstrated.

  5. SOUTH RAMP 3.01.X AREA GROUND SUPPORT ANALYSIS

    Energy Technology Data Exchange (ETDEWEB)

    S. Bonabian

    1999-07-12

    The purpose of this analysis is to evaluate the stability and determine ground support requirements for the 3.01.X areas in the Exploratory Studies Facility (ESF) South Ramp. The 3.01.X area refers to the ESF tunnel portions that were constructed under Section 3.01.X of the ESF General Construction Specification (Reference 8.4). Four 3.01.X areas in the ESF Main Loop are covered in this analysis that extend from Station 60+15.28 to 60+49.22, 62+04.82 to 62+32.77, 75+21.02 to 75+28.38, and 76+63.08 to 77+41.23. The scope of the analysis is (1) to document the as-built configuration including existing voids and installed ground support, (2) to evaluate the existing ground conditions, (3) to determine applicable design loads, (4) to evaluate the stability and determine a ground support system, and (5) to analyze the recommended system.

  6. Text analysis tools for identification of emerging topics and research gaps in conservation science.

    Science.gov (United States)

    Westgate, Martin J; Barton, Philip S; Pierson, Jennifer C; Lindenmayer, David B

    2015-12-01

    Keeping track of conceptual and methodological developments is a critical skill for research scientists, but this task is increasingly difficult due to the high rate of academic publication. As a crisis discipline, conservation science is particularly in need of tools that facilitate rapid yet insightful synthesis. We show how a common text-mining method (latent Dirichlet allocation, or topic modeling) and statistical tests familiar to ecologists (cluster analysis, regression, and network analysis) can be used to investigate trends and identify potential research gaps in the scientific literature. We tested these methods on the literature on ecological surrogates and indicators. Analysis of topic popularity within this corpus showed a strong emphasis on monitoring and management of fragmented ecosystems, while analysis of research gaps suggested a greater role for genetic surrogates and indicators. Our results show that automated text analysis methods need to be used with care, but can provide information that is complementary to that given by systematic reviews and meta-analyses, increasing scientists' capacity for research synthesis.

  7. Peptide Vocabulary Analysis Reveals Ultra-Conservation and Homonymity in Protein Sequences

    Directory of Open Access Journals (Sweden)

    Derek Gatherer

    2007-01-01

    Full Text Available A new algorithm is presented for vocabulary analysis (word detection in texts of human origin. It performs at 60%–70% overall accuracy and greater than 80% accuracy for longer words, and approximately 85% sensitivity on Alice in Wonderland, a considerable improvement on previous methods. When applied to protein sequences, it detects short sequences analogous to words in human texts, i.e. intolerant to changes in spelling (mutation, and relatively contextindependent in their meaning (function. Some of these are homonyms of up to 7 amino acids, which can assume different structures in different proteins. Others are ultra-conserved stretches of up to 18 amino acids within proteins of less than 40% overall identity, reflecting extreme constraint or convergent evolution. Different species are found to have qualitatively different major peptide vocabularies, e.g. some are dominated by large gene families, while others are rich in simple repeats or dominated by internally repetitive proteins. This suggests the possibility of a peptide vocabulary signature, analogous to genome signatures in DNA. Homonyms may be useful in detecting convergent evolution and positive selection in protein evolution. Ultra-conserved words may be useful in identifying structures intolerant to substitution over long periods of evolutionary time.

  8. Analysis of components of conserved "backbone sequences" among genomes of Shigella spp. strains

    Institute of Scientific and Technical Information of China (English)

    LIU Hong; PENG Junping; YANG Jian; SUN Lilian; CHEN Shuxia; Jin Qi

    2004-01-01

    Difference in the genomic compositions of prokaryotes is the basis of the diversity in their biological characters. However, besides their flora- or strain-specific genes, those floras with closer relationship in the evolution also have conserved "backbone sequences", which reveal the marks of their origin and evolution, and these "backbone sequences" are just the basis of their elementary living abilities and common biological properties. Shigella is very closely related to E. coli in the origin and evolution, and may turn out to belong to the same genus. In this study, a microarray containing E. coli K-12 whole genome and Sf301 specific ORFs is used to investigate the genomic components of four Shigella strains. The results indicate that 16%-22% K-12 ORFs sequences are not detected in the genome of Shigella strains while the genome of Shigella contains at least 2800 conserved ORFs, which compose the common "backbone sequences". Advanced analysis indicated that the "backbone sequences" are the essential components in maintaining the normal physiological activities of intestinal bacteria. Furthermore, only 20% Sf301-specific ORFs exist in other strains simultaneously, which demonstrate the great genome heterogeneity and the genetic diversity among the strains.

  9. Molecular genetic analysis of the yellow-breasted capuchin monkey: recommendations for ex situ conservation.

    Science.gov (United States)

    Oliveira, C G; Gaiotto, F A; Costa, M A; Martinez, R A

    2011-01-01

    The yellow-breasted capuchin monkey, Cebus xanthosternos, is one of the most endangered species of the Brazilian Atlantic Forest. In situ conservation for this species is problematic due to habitat destruction; therefore, captive conservation has been considered as an alternative strategy. A Studbook for C. xanthosternos has been kept for more than 20 years; however, no genetic data has been collected. Our aim was to provide a preliminary assessment of the genetic variability of C. xanthosternos in captivity in Brazil and compare it with data from the wild. Microsatellite and mtDNA sequencing were carried out in 40 samples from five Brazilian institutions registered in the international Studbook and compared with 8 samples collected in a wild population from REBIO-Una/BA. DNA for analysis was extracted from hair, feces and blood. Our results showed that two of the five captive groups assessed had a genetic variability comparable to wild animals. However, the other three groups apparently require urgent management to improve its genetic variability. Considering that inbreeding effects are more pronounced in captivity due to lack of gene flow, our data indicate a need to increase population size by introducing newly rescued individuals into these captive groups. Our results are the first attempt to provide genetic information for captive C. xanthosternos in Brazil.

  10. State of the interface between conservation and physiology: a bibliometric analysis

    OpenAIRE

    LENNOX, ROBERT; Cooke, Steven J.

    2014-01-01

    Contemporary conservation science benefits from the perspectives of a variety of different disciplines, including a recent synergy with physiology, an interface known as ‘conservation physiology’. To evaluate the degree of interaction between conservation and animal/plant physiology, we conducted three bibliometric analyses. We first pursued the use of the term ‘conservation physiology’ since its first definition in 2006 to determine how frequently it has been used and in which publications. ...

  11. Bioinformatic analysis of CaBP/calneuron proteins reveals a family of highly conserved vertebrate Ca2+-binding proteins

    Directory of Open Access Journals (Sweden)

    Burgoyne Robert D

    2010-04-01

    Full Text Available Abstract Background Ca2+-binding proteins are important for the transduction of Ca2+ signals into physiological outcomes. As in calmodulin many of the Ca2+-binding proteins bind Ca2+ through EF-hand motifs. Amongst the large number of EF-hand containing Ca2+-binding proteins are a subfamily expressed in neurons and retinal photoreceptors known as the CaBPs and the related calneuron proteins. These were suggested to be vertebrate specific but exactly which family members are expressed outside of mammalian species had not been examined. Findings We have carried out a bioinformatic analysis to determine when members of this family arose and the conserved aspects of the protein family. Sequences of human members of the family obtained from GenBank were used in Blast searches to identify corresponding proteins encoded in other species using searches of non-redundant proteins, genome sequences and mRNA sequences. Sequences were aligned and compared using ClustalW. Some families of Ca2+-binding proteins are known to show a progressive expansion in gene number as organisms increase in complexity. In contrast, the results for CaBPs and calneurons showed that a full complement of CaBPs and calneurons are present in the teleost fish Danio rerio and possibly in cartilaginous fish. These findings suggest that the entire family of genes may have arisen at the same time during vertebrate evolution. Certain members of the family (for example the short form of CaBP1 and calneuron 1 are highly conserved suggesting essential functional roles. Conclusions The findings support the designation of the calneurons as a distinct sub-family. While the gene number for CaBPs/calneurons does not increase, a distinctive evolutionary change in these proteins in vertebrates has been an increase in the number of splice variants present in mammals.

  12. Vibration testing and analysis of a multiply supported piping system

    Energy Technology Data Exchange (ETDEWEB)

    Hsieh, B.J.; Kot, C.A.; Srinivasan, M.G.

    1987-01-01

    The behavior of nuclear power plant piping systems during earthquake, and the most appropriate and economical mode of supporting such piping, is an issue of major concern. Consequently, the verification and validation of piping analysis methods and assumptions used in the design and safety assessment of nuclear power plants are of great interest. As part of its program on the validation of seismic calculational methods the US Nuclear Regulatory Commission (NRC) is specifically interested in the validation of the multiple support piping analysis module of the SMACS (Seismic Methodology Analysis Chain with Statistics) computer code. Data for the comparison of the dynamic behavior of various pipe hanger configurations and for the validation of piping response analyses were recently obtained in the large shaker experiments (SHAG) conducted at the HDR (Heissdampfreaktor) test facility in Kahl/Main, Federal Republic of Germany. This paper describes preliminary results from the SHAG piping response tests and the approach taken in the validation of the SMACS code piping analysis.

  13. Sensitivity analyses of spatial population viability analysis models for species at risk and habitat conservation planning.

    Science.gov (United States)

    Naujokaitis-Lewis, Ilona R; Curtis, Janelle M R; Arcese, Peter; Rosenfeld, Jordan

    2009-02-01

    Population viability analysis (PVA) is an effective framework for modeling species- and habitat-recovery efforts, but uncertainty in parameter estimates and model structure can lead to unreliable predictions. Integrating complex and often uncertain information into spatial PVA models requires that comprehensive sensitivity analyses be applied to explore the influence of spatial and nonspatial parameters on model predictions. We reviewed 87 analyses of spatial demographic PVA models of plants and animals to identify common approaches to sensitivity analysis in recent publications. In contrast to best practices recommended in the broader modeling community, sensitivity analyses of spatial PVAs were typically ad hoc, inconsistent, and difficult to compare. Most studies applied local approaches to sensitivity analyses, but few varied multiple parameters simultaneously. A lack of standards for sensitivity analysis and reporting in spatial PVAs has the potential to compromise the ability to learn collectively from PVA results, accurately interpret results in cases where model relationships include nonlinearities and interactions, prioritize monitoring and management actions, and ensure conservation-planning decisions are robust to uncertainties in spatial and nonspatial parameters. Our review underscores the need to develop tools for global sensitivity analysis and apply these to spatial PVA.

  14. Evaluation of Conservation Voltage Reduction with Analytic Hierarchy Process: A Decision Support Framework in Grid Operations Planning

    Directory of Open Access Journals (Sweden)

    Kyungsung An

    2016-12-01

    Full Text Available This paper presents a systematic framework to evaluate the performance of conservation voltage reduction (CVR by determining suitable substations for CVR in operations planning. Existing CVR planning practice generally only focuses on the energy saving aspect without taking other underlying attributes into account, i.e., network topology and reduced voltage effects on other substations. To secure the desired operating reserve and avoid any adverse impacts, these attributes should be considered for implementing CVR more effectively. This research develops a practical decision-making framework based on the analytic hierarchy process (AHP to quantify several of the aforementioned attributes. Candidate substations for CVR deployment are prioritized such that performances are compared in terms of power transfer distribution factor (PTDF, voltage sensitivity factor (VSF, and CVR factor. In addition, to meet a specified reserve requirement, an integer programming approach is adopted to select potential substations for CVR implementations. Case studies for a Korean electric power system under diverse operating conditions are performed to demonstrate the effectiveness of the proposed method.

  15. Tool for Sizing Analysis of the Advanced Life Support System

    Science.gov (United States)

    Yeh, Hue-Hsie Jannivine; Brown, Cheryl B.; Jeng, Frank J.

    2005-01-01

    Advanced Life Support Sizing Analysis Tool (ALSSAT) is a computer model for sizing and analyzing designs of environmental-control and life support systems (ECLSS) for spacecraft and surface habitats involved in the exploration of Mars and Moon. It performs conceptual designs of advanced life support (ALS) subsystems that utilize physicochemical and biological processes to recycle air and water, and process wastes in order to reduce the need of resource resupply. By assuming steady-state operations, ALSSAT is a means of investigating combinations of such subsystems technologies and thereby assisting in determining the most cost-effective technology combination available. In fact, ALSSAT can perform sizing analysis of the ALS subsystems that are operated dynamically or steady in nature. Using the Microsoft Excel spreadsheet software with Visual Basic programming language, ALSSAT has been developed to perform multiple-case trade studies based on the calculated ECLSS mass, volume, power, and Equivalent System Mass, as well as parametric studies by varying the input parameters. ALSSAT s modular format is specifically designed for the ease of future maintenance and upgrades.

  16. Online Social Support for Patients with Multiple Sclerosis: A Thematic Analysis of Messages Posted to a Virtual Support Community

    Directory of Open Access Journals (Sweden)

    Masoumeh Abbasi Shavazi

    2016-07-01

    Full Text Available Background: Currently with the emergence of the Internet, patients have an opportunity to exchange social support online. However, little attention has been devoted to different dimensions of online social support exchanged in virtual support communities for patients with multiple sclerosis (MS. Methods: To provide a rich insight, the aim of this qualitative study was to explore and categorize different dimensions of online social support in messages exchanged in a virtual support community for patients with MS. A total of 548 posted messages created during one year period were selected using purposive sampling to consider the maximum variation sampling. Prior-research-driven thematic analysis was then conducted. In this regard, we used the Cutruna and Suhr’s coding system. The messages that could not be categorized with the used coding system were thematically analyzed to explore new additional social support themes. Results: The results showed that various forms of social support including informational, emotional, network, esteem and tangible support were exchanged. Moreover, new additional social support themes including sharing personal experiences, sharing coping strategies and spiritual support emerged in this virtual support community. Conclusion: The wide range of online social support exchanged in the virtual support community can be regarded as a supplementary source of social support for patients with MS. Future researches can examine online social support more comprehensively considering additional social support themes emerging in the present study.

  17. [Geographic distribution of birds in the Sierra Madre Oriental of San Luis Potosi, Mexico: a regional analysis of conservation status].

    Science.gov (United States)

    Sahagún Sánchez, Francisco Javier; Navarro, Jaime Castro; Reyes Hernández, Humberto

    2013-06-01

    The Sierra Madre Oriental region in the mexican state of San Luis Potosi is a relevant place for bird conservation at a country level. Therefore the main goal of this study was to analyze the geographic patterns of distribution and the conservation current state of the birds, to support the needs to expand the conservation areas in the future. Data was collected from various databases of zoological museums and collections, and field sampling methods conducted from January 2009 to May 2011. Potential distributions were modeled for 284 species using GARP software and then a map was developed to determine areas with favorable environmental characteristics for the distribution of species richness. Finally, the importance of conservation areas for the potential distribution of birds in the region was evaluated. A total of 359 species were recorded of which 71.4% are permanent residents, 19% are winter migrants and 4% are summer residents. From this total, 41 species were endemic, 47 were species at risk and 149 were neotropical migrants. The largest species richness correspond to oak forests, cloud forests, and tropical moist forests located at altitudes from 100m to 1 500m. Their potential distribution was concentrated towards the center and Southeast of the study area. Only 10% of areas with a high potential conservation was included in areas of priority for bird conservation (AICA) and just 3% of all potential areas were under some governmental category of protection. However, no conservation area has a management plan currently applied and monitored. The information generated is important for the development of management proposals for birds conservation in the region.

  18. Development of an epitope conservancy analysis tool to facilitate the design of epitope-based diagnostics and vaccines

    Directory of Open Access Journals (Sweden)

    Fusseder Nicolas

    2007-09-01

    Full Text Available Abstract Background In an epitope-based vaccine setting, the use of conserved epitopes would be expected to provide broader protection across multiple strains, or even species, than epitopes derived from highly variable genome regions. Conversely, in a diagnostic and disease monitoring setting, epitopes that are specific to a given pathogen strain, for example, can be used to monitor responses to that particular infectious strain. In both cases, concrete information pertaining to the degree of conservancy of the epitope(s considered is crucial. Results To assist in the selection of epitopes with the desired degree of conservation, we have developed a new tool to determine the variability of epitopes within a given set of protein sequences. The tool was implemented as a component of the Immune Epitope Database and Analysis Resources (IEDB, and is directly accessible at http://tools.immuneepitope.org/tools/conservancy. Conclusion An epitope conservancy analysis tool was developed to analyze the variability or conservation of epitopes. The tool is user friendly, and is expected to aid in the design of epitope-based vaccines and diagnostics.

  19. Hypermedia support for engineering design systems: Application to fatigue analysis

    Science.gov (United States)

    Saeaeski, Juha; Sipilae, Sisko; Marquis, Gary

    1992-12-01

    The possibilities of using hypermedia for supporting engineering design systems are discussed. The application selected to test the hypermedia ideas was fatigue analysis. In addition, the possibility of combining hypermedia and expert system ideas into a fatigue expert system is reported. Hypermedia's underlying notion of linking nodes of information and its capability to handle these information entities stored appear to be well suited for engineering system support systems, especially in those engineering design systems where there exists a great demand for representing graphical information in a convenient way. This can be realized using hypermedia tools that are based on hypermedia techniques. The resulting fatigue handbook covers only part of the hypermedia's possibilities. The development of a prototype application indicates the efficiency of a hypermedia tool to create an electronic manual.

  20. Assessment of Transport Projects: Risk Analysis and Decision Support

    DEFF Research Database (Denmark)

    Salling, Kim Bang

    2008-01-01

    The subject of this thesis is risk analysis and decision support in the context of transport infrastructure assessment. During my research I have observed a tendency in studies of assessing transport projects of overlooking the substantial amount of uncertainties within the decision making process....... Even though vast amounts of money are spent upon preliminary models, environmental investigations, public hearings, etc., the resulting outcome is given by point estimates, i.e. in terms of net present values or benefit-cost rates. This thesis highlights the perspective of risks when assessing...... transport projects, namely by moving from point estimates to interval results. The main focus of this Ph.D. study has been to develop a valid, flexible and functional decision support tool in which risk oriented aspects of project evaluation is implemented. Throughout the study six papers have been produced...

  1. Accumulative job demands and support for strength use: Fine-tuning the job demands-resources model using conservation of resources theory.

    Science.gov (United States)

    van Woerkom, Marianne; Bakker, Arnold B; Nishii, Lisa H

    2016-01-01

    Absenteeism associated with accumulated job demands is a ubiquitous problem. We build on prior research on the benefits of counteracting job demands with resources by focusing on a still untapped resource for buffering job demands-that of strengths use. We test the idea that employees who are actively encouraged to utilize their personal strengths on the job are better positioned to cope with job demands. Based on conservation of resources (COR) theory, we hypothesized that job demands can accumulate and together have an exacerbating effect on company registered absenteeism. In addition, using job demands-resources theory, we hypothesized that perceived organizational support for strengths use can buffer the impact of separate and combined job demands (workload and emotional demands) on absenteeism. Our sample consisted of 832 employees from 96 departments (response rate = 40.3%) of a Dutch mental health care organization. Results of multilevel analyses indicated that high levels of workload strengthen the positive relationship between emotional demands and absenteeism and that support for strength use interacted with workload and emotional job demands in the predicted way. Moreover, workload, emotional job demands, and strengths use interacted to predict absenteeism. Strengths use support reduced the level of absenteeism of employees who experienced both high workload and high emotional demands. We conclude that providing strengths use support to employees offers organizations a tool to reduce absenteeism, even when it is difficult to redesign job demands.

  2. Taming Data to Make Decisions: Using a Spatial Fuzzy Logic Decision Support Framework to Inform Conservation and Land Use Planning

    Science.gov (United States)

    Sheehan, T.; Baker, B.; Degagne, R. S.

    2015-12-01

    With the abundance of data sources, analytical methods, and computer models, land managers are faced with the overwhelming task of making sense of a profusion of data of wildly different types. Luckily, fuzzy logic provides a method to work with different types of data using language-based propositions such as "the landscape is undisturbed," and a simple set of logic constructs. Just as many surveys allow different levels of agreement with a proposition, fuzzy logic allows values reflecting different levels of truth for a proposition. Truth levels fall within a continuum ranging from Fully True to Fully False. Hence a fuzzy logic model produces continuous results. The Environmental Evaluation Modeling System (EEMS) is a platform-independent, tree-based, fuzzy logic modeling framework. An EEMS model provides a transparent definition of an evaluation model and is commonly developed as a collaborative effort among managers, scientists, and GIS experts. Managers specify a set of evaluative propositions used to characterize the landscape. Scientists, working with managers, formulate functions that convert raw data values into truth values for the propositions and produce a logic tree to combine results into a single metric used to guide decisions. Managers, scientists, and GIS experts then work together to implement and iteratively tune the logic model and produce final results. We present examples of two successful EEMS projects that provided managers with map-based results suitable for guiding decisions: sensitivity and climate change exposure in Utah and the Colorado Plateau modeled for the Bureau of Land Management; and terrestrial ecological intactness in the Mojave and Sonoran region of southern California modeled for the Desert Renewable Energy Conservation Plan.

  3. Rapid detection and curation of conserved DNA via enhanced-BLAT and EvoPrinterHD analysis

    Directory of Open Access Journals (Sweden)

    Brody Thomas

    2008-02-01

    Full Text Available Abstract Background Multi-genome comparative analysis has yielded important insights into the molecular details of gene regulation. We have developed EvoPrinter, a web-accessed genomics tool that provides a single uninterrupted view of conserved sequences as they appear in a species of interest. An EvoPrint reveals with near base-pair resolution those sequences that are essential for gene function. Results We describe here EvoPrinterHD, a 2nd-generation comparative genomics tool that automatically generates from a single input sequence an enhanced view of sequence conservation between evolutionarily distant species. Currently available for 5 nematode, 3 mosquito, 12 Drosophila, 20 vertebrate, 17 Staphylococcus and 20 enteric bacteria genomes, EvoPrinterHD employs a modified BLAT algorithm [enhanced-BLAT (eBLAT], which detects up to 75% more conserved bases than identified by the BLAT alignments used in the earlier EvoPrinter program. The new program also identifies conserved sequences within rearranged DNA, highlights repetitive DNA, and detects sequencing gaps. EvoPrinterHD currently holds over 112 billion bp of indexed genomes in memory and has the flexibility of selecting a subset of genomes for analysis. An EvoDifferences profile is also generated to portray conserved sequences that are uniquely lost in any one of the orthologs. Finally, EvoPrinterHD incorporates options that allow for (1 re-initiation of the analysis using a different genome's aligning region as the reference DNA to detect species-specific changes in less-conserved regions, (2 rapid extraction and curation of conserved sequences, and (3 for bacteria, identifies unique or uniquely shared sequences present in subsets of genomes. Conclusion EvoPrinterHD is a fast, high-resolution comparative genomics tool that automatically generates an uninterrupted species-centric view of sequence conservation and enables the discovery of conserved sequences within rearranged DNA. When

  4. Construction of an integrated database to support genomic sequence analysis

    Energy Technology Data Exchange (ETDEWEB)

    Gilbert, W.; Overbeek, R.

    1994-11-01

    The central goal of this project is to develop an integrated database to support comparative analysis of genomes including DNA sequence data, protein sequence data, gene expression data and metabolism data. In developing the logic-based system GenoBase, a broader integration of available data was achieved due to assistance from collaborators. Current goals are to easily include new forms of data as they become available and to easily navigate through the ensemble of objects described within the database. This report comments on progress made in these areas.

  5. Information delivery manuals to facilitate it supported energy analysis

    DEFF Research Database (Denmark)

    Mondrup, Thomas Fænø; Karlshøj, Jan; Vestergaard, Flemming

    In response to continuing Building Information Modeling (BIM) progress, building performance simulation tools such as IESVE are being utilized to explore construction projects and influence design decisions with increasing frequency. To maximize the potential of these tools, a specification...... of information exchange and digital workflows is required. This paper presents the preliminary findings of an ongoing study aimed at developing an Information Delivery Manual (IDM) for IT supported energy analysis at concept design phase. The IDM development is based on: (1) a review of current approaches (2...

  6. Lie Symmetry Analysis, Conservation Laws and Exact Power Series Solutions for Time-Fractional Fordy-Gibbons Equation

    Science.gov (United States)

    Feng, Lian-Li; Tian, Shou-Fu; Wang, Xiu-Bin; Zhang, Tian-Tian

    2016-09-01

    In this paper, the time fractional Fordy-Gibbons equation is investigated with Riemann-Liouville derivative. The equation can be reduced to the Caudrey-Dodd-Gibbon equation, Savada-Kotera equation and the Kaup-Kupershmidt equation, etc. By means of the Lie group analysis method, the invariance properties and symmetry reductions of the equation are derived. Furthermore, by means of the power series theory, its exact power series solutions of the equation are also constructed. Finally, two kinds of conservation laws of the equation are well obtained with aid of the self-adjoint method. Supported by the Fundamental Research Funds for Key Discipline Construction under Grant No. XZD201602, the Fundamental Research Funds for the Central Universities under Grant Nos. 2015QNA53 and 2015XKQY14, the Fundamental Research Funds for Postdoctoral at the Key Laboratory of Gas and Fire Control for Coal Mines, the General Financial Grant from the China Postdoctoral Science Foundation under Grant No. 2015M570498, and Natural Sciences Foundation of China under Grant No. 11301527

  7. Securing water for wetland conservation: a comparative analysis of policy options to protect a national nature reserve in China.

    Science.gov (United States)

    Wu, Jian; Wu, Junjie; Wang, Xiaoxia; Zhong, Ma

    2012-02-01

    This study evaluates four policy options to secure the water supply needed for wetland conservation in Qixinghe--a national wetland nature reserve in China--using four criteria: cost effectiveness, probability of success in achieving the water-saving goal, political feasibility, and farmer acceptance. This multi-criteria analysis framework reveals the ecological, economic, and socio-political trade-offs for policymakers when choosing among the four policy options. Results suggest that upgrading irrigation infrastructure in the area surrounding the wetland (Option I) is the most politically feasible option, but it is the second best option in terms of cost effectiveness. Constructing a dam to store and control floodwater (Option II) is the most reliable for achieving the water-saving goal. It is also the farmers' most favored strategy. But this option is the least cost effective and receives little support from local governments. Promoting farmers' adoption of water-saving practices (Option III) is the most cost effective, but it is less reliable for achieving the water-saving goal than Options I or II. Converting paddy crops to dry-land crops (Option IV) is politically infeasible and least reliable for achieving the water-saving goal. The overall ranking of the four options is determined using the policymakers' revealed weights on the four criteria. Option I is ranked first, followed by Options II, III, and IV.

  8. Analysis of the Functional Independence Measure Value of Cervical Spine Injury Patients with Conservative Management

    Directory of Open Access Journals (Sweden)

    M. Zafrullah Arifin

    2012-06-01

    Full Text Available Analysis of the Functional Independence Measure Value of Cervical Spine Injury Patients with Conservative Management. Cervical spine injury is one of the most common spinal cord injuries in trauma patients. From 100,000 spinal cord injury cases reported in the United States of America (2008, sixty seven percent involve cervical spine injury. American Spinal Cord Injury Association (ASIA impairment score is used as an initial assessment but not enough attention prognostic outcome of these patients was paid to. The objective of this study is to analyze the value of functional independence measure (FIM cervical spine injury patients with conservative management and its correlation with age, sex, type of trauma, onset of trauma, cervical abnormalities, type of cervical spine lesion and ASIA impairment score. A prospective cohort study was performed to all patients with cervical spine injury treated inNeurosurgery Department of Dr. Hasan Sadikin Hospital Bandung that fullfiled the inclusion criteria. The subjects were classified based on age, sex, single/multiple trauma, acute /chronic, cervical abnormalities, complete/incomplete lesion and ASIA impairment score. The FIM examination was performed in Outpatient clinic of Neurosurgery. T-test and chi-square test was done to analyze the data. There were 17 cervical spine injury patients treated in Neurosurgery Department of Dr. Hasan Sadikin Hospital during April 2009–April 2010. The average FIM value of cervical spine injury in those patients is 4+ 1.63 by cohort prospective study. There were no correlation between FIM value with age, sex, type of trauma, onset of trauma and cervical abnormalities. Significant correlations were found between FIM value with type of cervical spine lesion and ASIA impairment score in cervical spine patients. Type of cervical spine lesion and ASIA impairment score have significant correlation with FIM value of patients in 6 months after cervical injury.

  9. Estimation of the stress related to conservative scoliosis therapy: an analysis based on BSSQ questionnaires

    Directory of Open Access Journals (Sweden)

    Szulc Andrzej

    2007-01-01

    Full Text Available Abstract Background Adolescent girls treated with a brace for scoliosis are submitted to prolonged stress related to both the disease and the therapy. Currently proposed quality of life questionnaires are focused on the outcome of therapy. Bad Sobernheim Stress Questionnaire (BSSQ enables monitoring of patients being under treatment with a brace or exercises. The aim of the study was to assess the stress level in conservatively managed scoliotic girls using BSSQ. Materials and methods 111 girls, aged 14,2 ± 2,2 years, mean Cobb angle of the primary curve 42,8° ± 17,0° and mean Bunnell angle of 11,4° ± 4,5° were examined with two versions of BSSQ (Deformity and Brace. The analysis considered the type of treatment, curve location, correlation of the total score with age, Cobb angle and Bunnell rotation angle. Results The BSSQ Deformity revealed the median of 17 points in patients managed with exercises (from 4 to 24 points, 18 in patients managed with a brace (from 8 to 24 points and 12 in patients before surgery (from 3 to 21 points. Braced patients who completed both questionnaires (n = 50 revealed significantly higher score with BSSQ Deformity (median = 18 comparing to BSSQ Brace (median = 9. There was a correlation between the total score of BSSQ Deformity and the Cobb angle (r = -0,34, Bunnell primary curve rotation (r = -0,34 and Bunnell sum of rotation (r = -0,33 but not with the age of patients. Conclusion Scoliotic adolescents managed with exercises and brace suffered little stress from the deformity. The brace increased the level of stress over the stress induced by the deformity. The stress level correlated with clinical deformity (Bunnell angle, radiological deformity (Cobb angle and the type of treatment (exercises, bracing, surgery. Bad Sobernheim Stress Questionnaires are simple and helpful in the management of girls treated conservatively for idiopathic scoliosis.

  10. Quantitative simulation tools to analyze up- and downstream interactions of soil and water conservation measures: supporting policy making in the Green Water Credits program of Kenya.

    Science.gov (United States)

    Hunink, J E; Droogers, P; Kauffman, S; Mwaniki, B M; Bouma, J

    2012-11-30

    Upstream soil and water conservation measures in catchments can have positive impact both upstream in terms of less erosion and higher crop yields, but also downstream by less sediment flow into reservoirs and increased groundwater recharge. Green Water Credits (GWC) schemes are being developed to encourage upstream farmers to invest in soil and water conservation practices which will positively effect upstream and downstream water availability. Quantitative information on water and sediment fluxes is crucial as a basis for such financial schemes. A pilot design project in the large and strategically important Upper-Tana Basin in Kenya has the objective to develop a methodological framework for this purpose. The essence of the methodology is the integration and use of a collection of public domain tools and datasets: the so-called Green water and Blue water Assessment Toolkit (GBAT). This toolkit was applied in order to study different options to implement GWC in agricultural rainfed land for the pilot study. Impact of vegetative contour strips, mulching, and tied ridges were determined for: (i) three upstream key indicators: soil loss, crop transpiration and soil evaporation, and (ii) two downstream indicators: sediment inflow in reservoirs and groundwater recharge. All effects were compared with a baseline scenario of average conditions. Thus, not only actual land management was considered but also potential benefits of changed land use practices. Results of the simulations indicate that especially applying contour strips or tied ridges significantly reduces soil losses and increases groundwater recharge in the catchment. The model was used to build spatial expressions of the proposed management practices in order to assess their effectiveness. The developed procedure allows exploring the effects of soil conservation measures in a catchment to support the implementation of GWC.

  11. A System Supporting the Analysis of Motorway Traffic Accidents

    Directory of Open Access Journals (Sweden)

    Davide Anghinolfi

    2015-12-01

    Full Text Available This work presents a business intelligence tool for monitoring traffic accidents on motorways and supporting decisions relevant to road safety. The system manages information on road characteristics, traffic accidents and traffic volumes and produces reports for monitoring the evolution of key performance indicators for road safety, supporting decisions on actions for risk mitigation and safety improvements for road users. The paper illustrates the different types of analyses performed by the system. Pattern based analysis is used to evaluate safety performance indicators for the road sections matching defined patterns. Two different road segmentation algorithms, used to identify the most critical road sections according to various severity indicators, are presented and discussed. Differential analysis compares the value of selected severity indicators before and after the implementation of an intervention on a road. Finally, a graphical user interface allows the accident locations to be visualized and accidents with specific characteristics to be highlighted. The system was evaluated on the data collected between 2009 and 2011 for the A15 motorway in Italy, connecting Parma to La Spezia.

  12. Porflow modeling supporting the FY14 salstone special analysis

    Energy Technology Data Exchange (ETDEWEB)

    Flach, G. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Taylor, G. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2014-04-01

    PORFLOW related analyses supporting the Saltstone FY14 Special Analysis (SA) described herein are based on prior modeling supporting the Saltstone FY13 SA. Notable changes to the previous round of simulations include: a) consideration of Saltstone Disposal Unit (SDU) design type 6 under “Nominal” and “Margin” conditions, b) omission of the clean cap fill from the nominal SDU 2 and 6 modeling cases as a reasonable approximation of greater waste grout fill heights, c) minor updates to the cementitious materials degradation analysis, d) use of updated I-129 sorption coefficient (Kd) values in soils, e) assignment of the pH/Eh environment of saltstone to the underlying floor concrete, considering down flow through an SDU, and f) implementation of an improved sub-model for Tc release in an oxidizing environment. These new model developments are discussed and followed by a cursory presentation of simulation results. The new Tc release sub-model produced significantly improved (smoother) flux results compared to the FY13 SA. Further discussion of PORFLOW model setup and simulation results will be presented in the FY14 SA, including dose results.

  13. Comparative genomics of Mycoplasma: analysis of conserved essential genes and diversity of the pan-genome.

    Directory of Open Access Journals (Sweden)

    Wei Liu

    Full Text Available Mycoplasma, the smallest self-replicating organism with a minimal metabolism and little genomic redundancy, is expected to be a close approximation to the minimal set of genes needed to sustain bacterial life. This study employs comparative evolutionary analysis of twenty Mycoplasma genomes to gain an improved understanding of essential genes. By analyzing the core genome of mycoplasmas, we finally revealed the conserved essential genes set for mycoplasma survival. Further analysis showed that the core genome set has many characteristics in common with experimentally identified essential genes. Several key genes, which are related to DNA replication and repair and can be disrupted in transposon mutagenesis studies, may be critical for bacteria survival especially over long period natural selection. Phylogenomic reconstructions based on 3,355 homologous groups allowed robust estimation of phylogenetic relatedness among mycoplasma strains. To obtain deeper insight into the relative roles of molecular evolution in pathogen adaptation to their hosts, we also analyzed the positive selection pressures on particular sites and lineages. There appears to be an approximate correlation between the divergence of species and the level of positive selection detected in corresponding lineages.

  14. Residue conservation and dimer-interface analysis of olfactory receptor molecular models

    Directory of Open Access Journals (Sweden)

    Ramanathan Sowdhamini

    2012-10-01

    Full Text Available Olfactory Receptors (ORs are members of the Class A rhodopsin like G-protein coupled receptors (GPCRs which are the initial players in the signal transduction cascade, leading to the generation of nerve impulses transmitted to the brain and resulting in the detection of odorant molecules. Despite the accumulation of thousands of olfactory receptor sequences, no crystal structures of ORs are known tο date. However, the recent availability of crystallographic models of a few GPCRs allows us to generate homology models of ORs and analyze their amino acid patterns, as there is a huge diversity in OR sequences. In this study, we have generated three-dimensional models of 100 representative ORs from Homo sapiens, Mus musculus, Drosophila melanogaster, Caenorhabditis elegans and Sacharomyces cerevisiae which were selected on the basis of a composite classification scheme and phylogenetic analysis. The crystal structure of bovine rhodopsin was used as a template and it was found that the full-length models have more than 90% of their residues in allowed regions of the Ramachandran plot. The structures were further used for analysis of conserved residues in the transmembrane and extracellular loop regions in order to identify functionally important residues. Several ORs are known to be functional as dimers and hence dimer interfaces were predicted for OR models to analyse their oligomeric functional state.

  15. Clinical decision support tools: analysis of online drug information databases

    Directory of Open Access Journals (Sweden)

    Seamon Matthew J

    2007-03-01

    Full Text Available Abstract Background Online drug information databases are used to assist in enhancing clinical decision support. However, the choice of which online database to consult, purchase or subscribe to is likely made based on subjective elements such as history of use, familiarity, or availability during professional training. The purpose of this study was to evaluate clinical decision support tools for drug information by systematically comparing the most commonly used online drug information databases. Methods Five commercially available and two freely available online drug information databases were evaluated according to scope (presence or absence of answer, completeness (the comprehensiveness of the answers, and ease of use. Additionally, a composite score integrating all three criteria was utilized. Fifteen weighted categories comprised of 158 questions were used to conduct the analysis. Descriptive statistics and Chi-square were used to summarize the evaluation components and make comparisons between databases. Scheffe's multiple comparison procedure was used to determine statistically different scope and completeness scores. The composite score was subjected to sensitivity analysis to investigate the effect of the choice of percentages for scope and completeness. Results The rankings for the databases from highest to lowest, based on composite scores were Clinical Pharmacology, Micromedex, Lexi-Comp Online, Facts & Comparisons 4.0, Epocrates Online Premium, RxList.com, and Epocrates Online Free. Differences in scope produced three statistical groupings with Group 1 (best performers being: Clinical Pharmacology, Micromedex, Facts & Comparisons 4.0, Lexi-Comp Online, Group 2: Epocrates Premium and RxList.com and Group 3: Epocrates Free (p Conclusion Online drug information databases, which belong to clinical decision support, vary in their ability to answer questions across a range of categories.

  16. Analysis of Coupling between Soil and Water Conservation and Economic-social Development

    Institute of Scientific and Technical Information of China (English)

    Sun Xihua; Zhang Daimin; Wan Han; Chen Tingting; Yan Fujiang

    2009-01-01

    The coupling relation exists in water and soil conservation and economic-social development.The article analyses the relation of soil and water conservation and economic-social development stages as well as the coupling analytical method.Then calculates the expecting income by dispersing Markov decision and calculates the correlation coefficient and the relationship degree.The article obtains the relationship of soil and water conservation investments and all kinds of incomes.Finally,it analyzes the important meaning in socio-economic development of water and soil conservation.

  17. Supporting secure programming in web applications through interactive static analysis

    Directory of Open Access Journals (Sweden)

    Jun Zhu

    2014-07-01

    Full Text Available Many security incidents are caused by software developers’ failure to adhere to secure programming practices. Static analysis tools have been used to detect software vulnerabilities. However, their wide usage by developers is limited by the special training required to write rules customized to application-specific logic. Our approach is interactive static analysis, to integrate static analysis into Integrated Development Environment (IDE and provide in-situ secure programming support to help developers prevent vulnerabilities during code construction. No additional training is required nor are there any assumptions on ways programs are built. Our work is motivated in part by the observation that many vulnerabilities are introduced due to failure to practice secure programming by knowledgeable developers. We implemented a prototype interactive static analysis tool as a plug-in for Java in Eclipse. Our technical evaluation of our prototype detected multiple zero-day vulnerabilities in a large open source project. Our evaluations also suggest that false positives may be limited to a very small class of use cases.

  18. Supporting secure programming in web applications through interactive static analysis.

    Science.gov (United States)

    Zhu, Jun; Xie, Jing; Lipford, Heather Richter; Chu, Bill

    2014-07-01

    Many security incidents are caused by software developers' failure to adhere to secure programming practices. Static analysis tools have been used to detect software vulnerabilities. However, their wide usage by developers is limited by the special training required to write rules customized to application-specific logic. Our approach is interactive static analysis, to integrate static analysis into Integrated Development Environment (IDE) and provide in-situ secure programming support to help developers prevent vulnerabilities during code construction. No additional training is required nor are there any assumptions on ways programs are built. Our work is motivated in part by the observation that many vulnerabilities are introduced due to failure to practice secure programming by knowledgeable developers. We implemented a prototype interactive static analysis tool as a plug-in for Java in Eclipse. Our technical evaluation of our prototype detected multiple zero-day vulnerabilities in a large open source project. Our evaluations also suggest that false positives may be limited to a very small class of use cases.

  19. Fine mapping and conservation analysis of linear B-cell epitopes of peste des petits ruminants virus nucleoprotein.

    Science.gov (United States)

    Yu, Ruisong; Fan, Xiaoming; Xu, Wanxiang; Li, Wentao; Dong, Shijuan; Zhu, Yumin; He, Yaping; Tang, Haiping; Du, Rong; Li, Zhen

    2015-01-30

    Nucleoprotein (NP) is the most abundant and highly immunogenic protein of morbillivirus, and is presently the basis of most diagnostic assays for peste des petits ruminants virus (PPRV). In this study, fine epitope mapping and conservation analysis of linear B-cell epitopes on the PPRV NP has been undertaken using biosynthetic peptides. Nineteen linear B-cell epitopes were identified and their corresponding minimal motifs were located on the NP of PPRV China/Tibet/Geg/07-30. Conservation analysis indicated that ten of the 19 minimal motifs were conserved among 46 PPRV strains. Peptides containing the minimal motifs were recognized using anti-PPRV serum from a goat immunized with PPRV vaccine strain Nigeria 75/1. Identified epitopes and their motifs improve our understanding of the antigenic characteristics of PPRV NP and provide a basis for the development of epitope-based diagnostic assays.

  20. Phylogenomic analysis of kinetoplastids supports that trypanosomatids arose from within bodonids

    DEFF Research Database (Denmark)

    Deschamps, Philippe; Lara, Enrique; Marande, William

    2011-01-01

    -, Procryptobia sorokini -Parabodonida-, and Rhynchomonas nasuta -Neobodonida-). We identified 64 well-conserved proteins shared by these species, four trypanosomatids, and two closely related outgroup species (Euglena gracilis and Diplonema papillatum). Phylogenetic analysis of a concatenated data set yielded...

  1. Analysis of the Capacity of Google Trends to Measure Interest in Conservation Topics and the Role of Online News.

    Science.gov (United States)

    Nghiem, Le T P; Papworth, Sarah K; Lim, Felix K S; Carrasco, Luis R

    2016-01-01

    With the continuous growth of internet usage, Google Trends has emerged as a source of information to investigate how social trends evolve over time. Knowing how the level of interest in conservation topics--approximated using Google search volume--varies over time can help support targeted conservation science communication. However, the evolution of search volume over time and the mechanisms that drive peaks in searches are poorly understood. We conducted time series analyses on Google search data from 2004 to 2013 to investigate: (i) whether interests in selected conservation topics have declined and (ii) the effect of news reporting and academic publishing on search volume. Although trends were sensitive to the term used as benchmark, we did not find that public interest towards conservation topics such as climate change, ecosystem services, deforestation, orangutan, invasive species and habitat loss was declining. We found, however, a robust downward trend for endangered species and an upward trend for ecosystem services. The quantity of news articles was related to patterns in Google search volume, whereas the number of research articles was not a good predictor but lagged behind Google search volume, indicating the role of news in the transfer of conservation science to the public.

  2. Disgust and the politics of sex: exposure to a disgusting odorant increases politically conservative views on sex and decreases support for gay marriage.

    Directory of Open Access Journals (Sweden)

    Thomas G Adams

    Full Text Available Disgust has been implicated as a potential causal agent underlying socio-political attitudes and behaviors. Several recent studies have suggested that pathogen disgust may be a causal mechanism underlying social conservatism. However, the specificity of this effect is still in question. The present study tested the effects of disgust on a range of policy preferences to clarify whether disgust is generally implicated in political conservatism across public policy attitudes or is uniquely related to specific content domains. Self-reported socio-political attitudes were compared between participants in two experimental conditions: 1 an odorless control condition, and 2 a disgusting odor condition. In keeping with previous research, the present study showed that exposure to a disgusting odor increased endorsement of socially conservative attitudes related to sexuality. In particular, there was a strong and consistent link between induced disgust and less support for gay marriage.

  3. Disgust and the politics of sex: exposure to a disgusting odorant increases politically conservative views on sex and decreases support for gay marriage.

    Science.gov (United States)

    Adams, Thomas G; Stewart, Patrick A; Blanchar, John C

    2014-01-01

    Disgust has been implicated as a potential causal agent underlying socio-political attitudes and behaviors. Several recent studies have suggested that pathogen disgust may be a causal mechanism underlying social conservatism. However, the specificity of this effect is still in question. The present study tested the effects of disgust on a range of policy preferences to clarify whether disgust is generally implicated in political conservatism across public policy attitudes or is uniquely related to specific content domains. Self-reported socio-political attitudes were compared between participants in two experimental conditions: 1) an odorless control condition, and 2) a disgusting odor condition. In keeping with previous research, the present study showed that exposure to a disgusting odor increased endorsement of socially conservative attitudes related to sexuality. In particular, there was a strong and consistent link between induced disgust and less support for gay marriage.

  4. Targeting and valuing conservation investments in support of a water fund: linking upstream land management with downstream services in the Upper Tana catchment, Kenya

    Science.gov (United States)

    Bryant, B. P.; Droogers, P.; Hunink, J.; Vogl, A.; Wolny, S.

    2014-12-01

    We apply an integrated modeling framework to both target and value watershed management interventions in the Upper Tana watershed, which provides municipal water, irrigation water, and hydropower services to Nairobi and surrounding areas. The analysis begins by applying an index model approach that incorporates existing land use and land surface characteristics to prioritize the type and location of conservation investments in different subbasins, subject to budget constraints and stakeholder concerns (Resource Investment Optimization System -- RIOS). We then run the Soil and Water Assessment Tool (SWAT) using the RIOS-identified investment scenarios to produce spatially explicit scenarios that simulate changes in water yield and suspended sediment. Finally, we link those biophysical outputs to monetary and non-monetary human well-being metrics for multiple benefit streams, including: Reduced water treatment costs, increased hydropower production, and crop yield benefits for upstream farmers in the conservation area. The viability of a payment for watershed services scheme is discussed, with attention to the various components of value assessed and to dependencies on water management approaches. While other studies have examined links between land use and the provision of hydrologic services, this study is novel in that it presents an integrated analysis that targets interventions in a decision context and then relies on calibrated, process-based, biophysical models to demonstrate the return on those investments considering multiple (and sometimes competing) hydrological services, doing so at a sub-annual time-scale.

  5. Cost analysis in support of minimum energy standards for clothes washers and dryers

    Energy Technology Data Exchange (ETDEWEB)

    1979-02-02

    The results of the cost analysis of energy conservation design options for laundry products are presented. The analysis was conducted using two approaches. The first, is directed toward the development of industrial engineering cost estimates of each energy conservation option. This approach results in the estimation of manufacturers costs. The second approach is directed toward determining the market price differential of energy conservation features. The results of this approach are shown. The market cost represents the cost to the consumer. It is the final cost, and therefore includes distribution costs as well as manufacturing costs.

  6. Urban Conservation As A Development Strategy to Revitalize Real Estate Market: An Analysis Of Property Transactions In Georgetown Penang

    Directory of Open Access Journals (Sweden)

    Nor’ Aini Yusof

    2007-12-01

    Full Text Available Penang is well known for its heritage character especially in the city of Georgetown with more than 200 years of urban history. To retain its heritage character, the state and local governments have implemented various conservation policies and identified a heritage zone in the inner city of Georgetown. In many parts of the world, designation as a heritage property would have increased a property’s value and this is one of the reasons put forward for urban effects of conservation related policies on the heritage property market. In this paper, we focus the analysis on data from property transactions and price to intervention strategies, socio-economic and political changes. Our analysis of the transaction date and price trends shows that urban conservation has a potential to be a viable real estate development strategy for Georgetown. Even with conservation policies to place, the demand for old buildings in the conservation zones has not diminished but has shown relatively high transaction counts and high price of heritage properties.

  7. Developing SASSA: a Soil Analysis Support System for Archaeologists

    Directory of Open Access Journals (Sweden)

    Clare Wilson

    2008-12-01

    Full Text Available There is constant pressure on field archaeologists to be familiar with the core concepts of a diverse range of specialist disciplines. Soils and sediments are an integral part of archaeological sites, and soil and sedimentary analyses applied to archaeological questions are now recognised as an important branch of geoarchaeology. However, the teaching of soils in archaeology degrees is variable and many archaeologists complain they lack the confidence and skills to describe and interpret properly the deposits they excavate. SASSA (Soil Analysis Support System for Archaeologists is a free-to-use, internet-based system designed to familiarise archaeologists with the concepts and possibilities offered by the scientific study of soils and sediments associated with archaeological sites. The aims of SASSA are: ◦To provide soils training specifically for archaeologists, suitable for either a university or workplace setting. ◦To provide a freely accessible soils and archaeology knowledge base for archaeologists working in either the office or the field. ◦To support archaeologists describing and interpreting soils in the field. ◦To enhance understanding of the types of archaeological questions that soil analysis can help to address. ◦To initiate dialogue between archaeologists, geoarchaeologists, and soil scientists in order to encourage the thoughtful application of soil analyses to archaeological questions. SASSA consists of two core components: a knowledge base and a field tool. The 'front-end' of the website is the knowledge base; this uses wiki technology to allow users to add their own content and encourage dialogue between archaeologists and geoarchaeologists. The field tool uses an XML data structure and decision-tree support system to guide the user through the process of describing and interpreting soils and sediments. SASSA is designed for use on both 'static' (PC and 'mobile' (PDA and laptop hardware in order to provide in situ

  8. Direct Analysis in Real Time Mass Spectrometry for the Nondestructive Investigation of Conservation Treatments of Cultural Heritage.

    Science.gov (United States)

    Manfredi, Marcello; Robotti, Elisa; Bearman, Greg; France, Fenella; Barberis, Elettra; Shor, Pnina; Marengo, Emilio

    2016-01-01

    Today the long-term conservation of cultural heritage is a big challenge: often the artworks were subjected to unknown interventions, which eventually were found to be harmful. The noninvasive investigation of the conservation treatments to which they were subjected to is a crucial step in order to undertake the best conservation strategies. We describe here the preliminary results on a quick and direct method for the nondestructive identification of the various interventions of parchment by means of direct analysis in real time (DART) ionization and high-resolution time-of-flight mass spectrometry and chemometrics. The method has been developed for the noninvasive analysis of the Dead Sea Scrolls, one of the most important archaeological discoveries of the 20th century. In this study castor oil and glycerol parchment treatments, prepared on new parchment specimens, were investigated in order to evaluate two different types of operations. The method was able to identify both treatments. In order to investigate the effect of the ion source temperature on the mass spectra, the DART-MS analysis was also carried out at several temperatures. Due to the high sensitivity, simplicity, and no sample preparation requirement, the proposed analytical methodology could help conservators in the challenging analysis of unknown treatments in cultural heritage.

  9. The use of SWOT analysis to explore and prioritize conservation and development strategies for local cattle breeds..

    NARCIS (Netherlands)

    Martin-Collado, D.; Diaz, D.; Mäki-Tanila, A.; Colinet, F.; Duclos, D.; Hiemstra, S.J.; Gandini, G.

    2013-01-01

    SWOT (Strengths, Weaknesses, Opportunities and Threats) analysis is a tool widely used to help in decision making in complex systems. It suits to exploring the issues and measures related to the conservation and development of local breeds, as it allows the integration of many driving factors influe

  10. Direct Analysis in Real Time Mass Spectrometry for the Nondestructive Investigation of Conservation Treatments of Cultural Heritage

    Directory of Open Access Journals (Sweden)

    Marcello Manfredi

    2016-01-01

    Full Text Available Today the long-term conservation of cultural heritage is a big challenge: often the artworks were subjected to unknown interventions, which eventually were found to be harmful. The noninvasive investigation of the conservation treatments to which they were subjected to is a crucial step in order to undertake the best conservation strategies. We describe here the preliminary results on a quick and direct method for the nondestructive identification of the various interventions of parchment by means of direct analysis in real time (DART ionization and high-resolution time-of-flight mass spectrometry and chemometrics. The method has been developed for the noninvasive analysis of the Dead Sea Scrolls, one of the most important archaeological discoveries of the 20th century. In this study castor oil and glycerol parchment treatments, prepared on new parchment specimens, were investigated in order to evaluate two different types of operations. The method was able to identify both treatments. In order to investigate the effect of the ion source temperature on the mass spectra, the DART-MS analysis was also carried out at several temperatures. Due to the high sensitivity, simplicity, and no sample preparation requirement, the proposed analytical methodology could help conservators in the challenging analysis of unknown treatments in cultural heritage.

  11. Tradeoff Analysis for Combat Service Support Wireless Communications Alternatives

    Energy Technology Data Exchange (ETDEWEB)

    Burnette, John R.; Thibodeau, Christopher C.; Greitzer, Frank L.

    2002-02-28

    As the Army moves toward more mobile and agile forces and continued sustainment of numerous high-cost legacy logistics management systems, the requirement for wireless connectivity and a wireless network to supporting organizations has become ever more critical. There are currently several Army communications initiatives underway to resolve this wireless connectivity issue. However, to fully appreciate and understand the value of these initiatives, a Tradeoff Analysis is needed. The present study seeks to identify and assess solutions. The analysis identified issues that impede Interim Brigade Combat Team (IBCT) communication system integration and outlined core requirements for sharing of logistics data between the field and Army battle command systems. Then, the analysis examined wireless communication alternatives as possible solutions for IBCT logistics communications problems. The current baseline system was compared with possible alternatives involving tactical radio systems, wireless/near term digital radio, cellular satellite, and third-generation (3G) wireless technologies. Cellular satellite and 3G wireless technologies offer clear advantages and should be considered for later IBCTs.

  12. How qualitative data analysis software may support the qualitative analysis process

    NARCIS (Netherlands)

    Peters, V.A.M.; Wester, F.P.J.

    2007-01-01

    The last decades have shown large progress in the elaboration of procedures for qualitative data analysis and in the development of computer programs to support this kind of analysis. We believe, however, that the link between methodology and computer software tools is too loose, especially for a no

  13. Conservation and early expression of zebrafish tyrosine kinases support the utility of zebrafish as a model for tyrosine kinase biology.

    Science.gov (United States)

    Challa, Anil Kumar; Chatti, Kiranam

    2013-09-01

    Tyrosine kinases have significant roles in cell growth, apoptosis, development, and disease. To explore the use of zebrafish as a vertebrate model for tyrosine kinase signaling and to better understand their roles, we have identified all of the tyrosine kinases encoded in the zebrafish genome and quantified RNA expression of selected tyrosine kinases during early development. Using profile hidden Markov model analysis, we identified 122 zebrafish tyrosine kinase genes and proposed unambiguous gene names where needed. We found them to be organized into 39 nonreceptor and 83 receptor type, and 30 families consistent with human tyrosine kinase family assignments. We found five human tyrosine kinase genes (epha1, bmx, fgr, srm, and insrr) with no identifiable zebrafish ortholog, and one zebrafish gene (yrk) with no identifiable human ortholog. We also found that receptor tyrosine kinase genes were duplicated more often than nonreceptor tyrosine kinase genes in zebrafish. We profiled expression levels of 30 tyrosine kinases representing all families using direct digital detection at different stages during the first 24 hours of development. The profiling experiments clearly indicate regulated expression of tyrosine kinases in the zebrafish, suggesting their role during early embryonic development. In summary, our study has resulted in the first comprehensive description of the zebrafish tyrosine kinome.

  14. Portable Life Support Subsystem Thermal Hydraulic Performance Analysis

    Science.gov (United States)

    Barnes, Bruce; Pinckney, John; Conger, Bruce

    2010-01-01

    This paper presents the current state of the thermal hydraulic modeling efforts being conducted for the Constellation Space Suit Element (CSSE) Portable Life Support Subsystem (PLSS). The goal of these efforts is to provide realistic simulations of the PLSS under various modes of operation. The PLSS thermal hydraulic model simulates the thermal, pressure, flow characteristics, and human thermal comfort related to the PLSS performance. This paper presents modeling approaches and assumptions as well as component model descriptions. Results from the models are presented that show PLSS operations at steady-state and transient conditions. Finally, conclusions and recommendations are offered that summarize results, identify PLSS design weaknesses uncovered during review of the analysis results, and propose areas for improvement to increase model fidelity and accuracy.

  15. Support vector classifier based on principal component analysis

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Support vector classifier (SVC) has the superior advantages for small sample learning problems with high dimensions,with especially better generalization ability.However there is some redundancy among the high dimensions of the original samples and the main features of the samples may be picked up first to improve the performance of SVC.A principal component analysis (PCA) is employed to reduce the feature dimensions of the original samples and the pre-selected main features efficiently,and an SVC is constructed in the selected feature space to improve the learning speed and identification rate of SVC.Furthermore,a heuristic genetic algorithm-based automatic model selection is proposed to determine the hyperparameters of SVC to evaluate the performance of the learning machines.Experiments performed on the Heart and Adult benchmark data sets demonstrate that the proposed PCA-based SVC not only reduces the test time drastically,but also improves the identify rates effectively.

  16. Analysis of National and EU Policies Supporting CSR and Impact

    DEFF Research Database (Denmark)

    Moon, Jeremy; Slager, Rieneke; Anastasiadis, Stephanos

    The purpose of this report is to provide an overview of the place of governmental policies in encouraging and supporting Corporate Social Responsibility (CSR) and their effectiveness therein. By: Moon, Jeremy - Slager, Rieneke - Brunn, Christoph - Hardi, Peter - Steen Knudsen, Jette - 2012 The very...... thought of a relationship between CSR and government policies would, from some perspectives, seem counter-intuitive or simply wrong. From these perspectives it would appear to be a category error that a concept founded on voluntarism, vs CSR, should be shaped by the antithesis of voluntarism, vs public...... policy. What the report finds however is that in general terms there has been a remarkable growth of public policies for CSR in Europe. This finding is confirmed both by review of the relevant literature but also our own pan-European analysis. No longer is CSR mainly implicit in public policies...

  17. Anonymization of Electronic Medical Records to Support Clinical Analysis

    CERN Document Server

    Gkoulalas-Divanis, Aris

    2013-01-01

    Anonymization of Electronic Medical Records to Support Clinical Analysis closely examines the privacy threats that may arise from medical data sharing, and surveys the state-of-the-art methods developed to safeguard data against these threats. To motivate the need for computational methods, the book first explores the main challenges facing the privacy-protection of medical data using the existing policies, practices and regulations. Then, it takes an in-depth look at the popular computational privacy-preserving methods that have been developed for demographic, clinical and genomic data sharing, and closely analyzes the privacy principles behind these methods, as well as the optimization and algorithmic strategies that they employ. Finally, through a series of in-depth case studies that highlight data from the US Census as well as the Vanderbilt University Medical Center, the book outlines a new, innovative class of privacy-preserving methods designed to ensure the integrity of transferred medical data for su...

  18. Insurance Contract Analysis for Company Decision Support in Acquisition Management

    Science.gov (United States)

    Chernovita, H. P.; Manongga, D.; Iriani, A.

    2017-01-01

    One of company activities to retain their business is marketing the products which include in acquisition management to get new customers. Insurance contract analysis using ID3 to produce decision tree and rules to be decision support for the insurance company. The decision tree shows 13 rules that lead to contract termination claim. This could be a guide for the insurance company in acquisition management to prevent contract binding with these contract condition because it has a big chance for the customer to terminate their insurance contract before its expired date. As the result, there are several strong points that could be the determinant of contract termination such as: 1) customer age whether too young or too old, 2) long insurance period (above 10 years), 3) big insurance amount, 4) big amount of premium charges, and 5) payment method.

  19. Computational Analysis of an Evolutionarily Conserved VertebrateMuscle Alternative Splicing Program

    Energy Technology Data Exchange (ETDEWEB)

    Das, Debopriya; Clark, Tyson A.; Schweitzer, Anthony; Marr,Henry; Yamamoto, Miki L.; Parra, Marilyn K.; Arribere, Josh; Minovitsky,Simon; Dubchak, Inna; Blume, John E.; Conboy, John G.

    2006-06-15

    A novel exon microarray format that probes gene expression with single exon resolution was employed to elucidate critical features of a vertebrate muscle alternative splicing program. A dataset of 56 microarray-defined, muscle-enriched exons and their flanking introns were examined computationally in order to investigate coordination of the muscle splicing program. Candidate intron regulatory motifs were required to meet several stringent criteria: significant over-representation near muscle-enriched exons, correlation with muscle expression, and phylogenetic conservation among genomes of several vertebrate orders. Three classes of regulatory motifs were identified in the proximal downstream intron, within 200nt of the target exons: UGCAUG, a specific binding site for Fox-1 related splicing factors; ACUAAC, a novel branchpoint-like element; and UG-/UGC-rich elements characteristic of binding sites for CELF splicing factors. UGCAUG was remarkably enriched, being present in nearly one-half of all cases. These studies suggest that Fox and CELF splicing factors play a major role in enforcing the muscle-specific alternative splicing program, facilitating expression of a set of unique isoforms of cytoskeletal proteins that are critical to muscle cell differentiation. Supplementary materials: There are four supplementary tables and one supplementary figure. The tables provide additional detailed information concerning the muscle-enriched datasets, and about over-represented oligonucleotide sequences in the flanking introns. The supplementary figure shows RT-PCR data confirming the muscle-enriched expression of exons predicted from the microarray analysis.

  20. Comprehensive analysis of animal TALE homeobox genes: new conserved motifs and cases of accelerated evolution.

    Science.gov (United States)

    Mukherjee, Krishanu; Bürglin, Thomas R

    2007-08-01

    TALE homeodomain proteins are an ancient subgroup within the group of homeodomain transcription factors that play important roles in animal, plant, and fungal development. We have extracted the full complement of TALE superclass homeobox genes from the genome projects of seven protostomes, seven deuterostomes, and Nematostella. This was supplemented with TALE homeobox genes from additional species and phylogenetic analyses were carried out with 276 sequences. We found 20 homeobox genes and 4 pseudogenes in humans, 21 genes in mouse, 8 genes in Drosophila, and 5 genes plus one truncated gene in Caenorhabditis elegans. Apart from the previously identified TALE classes MEIS, PBC, IRO, and TGIF, a novel class is identified, termed MOHAWK (MKX). Further, we show that the MEIS class can be divided into two families, PREP and MEIS. Prep genes have previously only been described in vertebrates but are lacking in Drosophila. Here we identify orthologues in other insect taxa as well as in the cnidarian Nematostella. In C. elegans, a divergent Prep protein has lost the homeodomain. Full-length multiple sequence alignment of the protostome and deuterostome sequences allowed us to identify several novel conserved motifs within the MKX, TGIF, and MEIS classes. Phylogenetic analyses revealed fast-evolving PBC class genes; in particular, some X-linked PBC genes in nematodes are subject to rapid evolution. In addition, several instances of gene loss were identified. In conclusion, our comprehensive analysis provides a defining framework for the classification of animal TALE homeobox genes and the understanding of their evolution.

  1. Energy Conservation Analysis and Control of Hybrid Active Semiactive Suspension with Three Regulating Damping Levels

    Directory of Open Access Journals (Sweden)

    Long Chen

    2016-01-01

    Full Text Available Active suspension has not been popularized for high energy consumption. To address this issue, this paper introduces the concept of a new kind of suspension. The linear motor is considered to be integrated into an adjustable shock absorber to form the hybrid active semiactive suspension (HASAS. To realize the superiority of HASAS, its energy consumption and regeneration mechanisms are revealed. And the system controller which is composed of linear quadratic regulator (LQR controller, mode decision and switch controller, and the sliding mode control based thrust controller is developed. LQR controller is designed to maintain the suspension control objectives, while mode decision and switch controller decides the optimal damping level to tune motor thrust. The thrust controller ensures motor thrust tracking. An adjustable shock absorber with three regulating levels to be used in HASAS is trial produced and tested to obtain its working characteristics. Finally, simulation analysis is made with the experimental three damping characteristics. The impacts of adjustable damping on the motor force and energy consumption are investigated. Simulation results demonstrate the advantages of HASAS in energy conservation with various suspension control objectives. Even self-powered active control and energy regenerated to the power source can be realized.

  2. Conservation analysis of dengue virus T-cell epitope-based vaccine candidates using peptide block entropy

    Directory of Open Access Journals (Sweden)

    Lars Ronn Olsen

    2011-12-01

    Full Text Available Broad coverage of the pathogen population is particularly important when designing CD8+ T-cell epitope vaccines against viral pathogens. Traditional approaches to assembling broadly covering sets of peptides are commonly based on assembling highly conserved epitopes. Peptide block entropy analysis is a novel approach to assembling sets of broadly covering antigens. Since T-cell epitopes are recognized as peptides rather than individual residues, this method is based on calculating the information content of blocks of peptides from a multiple sequence alignment of homologous proteins rather than individual residues. The block entropy analysis provides broad coverage by variant inclusion, since high frequency may not be the sole determinant of the immunogenic potential of a predicted MHC class I binder. We applied block entropy analysis method to the proteomes of the four serotypes of dengue virus and found 1,551 blocks of 9-mer peptides, which covered all available sequences with five or fewer unique peptides. In contrast, the benchmark study by Khan et al. (2008, resulted in 165 9-mers being determined as conserved. Many of the blocks are located consecutively in the proteins, so connecting these blocks resulted in 78 conserved regions which can be covered with 457 subunit peptides. Of the 1551 blocks of 9-mer peptides, 110 blocks consisted of peptides all predicted to bind to MHC with similar affinity and the same HLA restriction. In total, we identified a pool of 333 peptides as T-cell epitope candidates. This set could form the basis for a broadly neutralizing dengue virus vaccine. The peptide block entropy analysis approach significantly increases the number of conserved peptide regions in comparison to traditional conservation analysis of individual residues. We determined 457 subunit peptides with the capacity to encompass the diversity of all sequenced DENV strains.

  3. Analysis of conserved microRNAs in floral tissues of sexual and apomictic Boechera species

    Directory of Open Access Journals (Sweden)

    Vogel Heiko

    2011-10-01

    Full Text Available Abstract Background Apomixis or asexual seed formation represents a potentially important agronomic trait whose introduction into crop plants could be an effective way to fix and perpetuate a desirable genotype through successive seed generations. However, the gene regulatory pathways underlying apomixis remain unknown. In particular, the potential function of microRNAs, which are known to play crucial roles in many aspects of plant growth and development, remains to be determined with regards to the switch from sexual to apomictic reproduction. Results Using bioinformatics and microarray validation procedures, 51 miRNA families conserved among angiosperms were identified in Boechera. Microarray assay confirmed 15 of the miRNA families that were identified by bioinformatics techniques. 30 cDNA sequences representing 26 miRNAs could fold back into stable pre-miRNAs. 19 of these pre-miRNAs had miRNAs with Boechera-specific nucleotide substitutions (NSs. Analysis of the Gibbs free energy (ΔG of these pre-miRNA stem-loops with NSs showed that the Boechera-specific miRNA NSs significantly (p ≤ 0.05 enhance the stability of stem-loops. Furthermore, six transcription factors, the Squamosa promoter binding protein like SPL6, SPL11 and SPL15, Myb domain protein 120 (MYB120, RELATED TO AP2.7 DNA binding (RAP2.7, TOE1 RAP2.7 and TCP family transcription factor 10 (TCP10 were found to be expressed in sexual or apomictic ovules. However, only SPL11 showed differential expression with significant (p ≤ 0.05 up-regulation at the megaspore mother cell (MMC stage of ovule development in apomictic genotypes. Conclusions This study constitutes the first extensive insight into the conservation and expression of microRNAs in Boechera sexual and apomictic species. The miR156/157 target squamosa promoter binding protein-like 11 (SPL11 was found differentially expressed with significant (p ≤ 0.05 up-regulation at the MMC stage of ovule development in apomictic

  4. Comparative analysis of evolutionarily conserved motifs of epidermal growth factor receptor 2 (HER2 predicts novel potential therapeutic epitopes.

    Directory of Open Access Journals (Sweden)

    Xiaohong Deng

    Full Text Available Overexpression of human epidermal growth factor receptor 2 (HER2 is associated with tumor aggressiveness and poor prognosis in breast cancer. With the availability of therapeutic antibodies against HER2, great strides have been made in the clinical management of HER2 overexpressing breast cancer. However, de novo and acquired resistance to these antibodies presents a serious limitation to successful HER2 targeting treatment. The identification of novel epitopes of HER2 that can be used for functional/region-specific blockade could represent a central step in the development of new clinically relevant anti-HER2 antibodies. In the present study, we present a novel computational approach as an auxiliary tool for identification of novel HER2 epitopes. We hypothesized that the structurally and linearly evolutionarily conserved motifs of the extracellular domain of HER2 (ECD HER2 contain potential druggable epitopes/targets. We employed the PROSITE Scan to detect structurally conserved motifs and PRINTS to search for linearly conserved motifs of ECD HER2. We found that the epitopes recognized by trastuzumab and pertuzumab are located in the predicted conserved motifs of ECD HER2, supporting our initial hypothesis. Considering that structurally and linearly conserved motifs can provide functional specific configurations, we propose that by comparing the two types of conserved motifs, additional druggable epitopes/targets in the ECD HER2 protein can be identified, which can be further modified for potential therapeutic application. Thus, this novel computational process for predicting or searching for potential epitopes or key target sites may contribute to epitope-based vaccine and function-selected drug design, especially when x-ray crystal structure protein data is not available.

  5. Gradient Analysis and Classification of Carolina Bay Vegetation: A Framework for Bay Wetlands Conservation and Restoration

    Energy Technology Data Exchange (ETDEWEB)

    Diane De Steven,Ph.D.; Maureen Tone,PhD.

    1997-10-01

    This report address four project objectives: (1) Gradient model of Carolina bay vegetation on the SRS--The authors use ordination analyses to identify environmental and landscape factors that are correlated with vegetation composition. Significant factors can provide a framework for site-based conservation of existing diversity, and they may also be useful site predictors for potential vegetation in bay restorations. (2) Regional analysis of Carolina bay vegetation diversity--They expand the ordination analyses to assess the degree to which SRS bays encompass the range of vegetation diversity found in the regional landscape of South Carolina's western Upper Coastal Plain. Such comparisons can indicate floristic status relative to regional potentials and identify missing species or community elements that might be re-introduced or restored. (3) Classification of vegetation communities in Upper Coastal Plain bays--They use cluster analysis to identify plant community-types at the regional scale, and explore how this classification may be functional with respect to significant environmental and landscape factors. An environmentally-based classification at the whole-bay level can provide a system of templates for managing bays as individual units and for restoring bays to desired plant communities. (4) Qualitative model for bay vegetation dynamics--They analyze present-day vegetation in relation to historic land uses and disturbances. The distinctive history of SRS bays provides the possibility of assessing pathways of post-disturbance succession. They attempt to develop a coarse-scale model of vegetation shifts in response to changing site factors; such qualitative models can provide a basis for suggesting management interventions that may be needed to maintain desired vegetation in protected or restored bays.

  6. Functional conservation analysis and expression modes of grape anthocyanin synthesis genes responsive to low temperature stress.

    Science.gov (United States)

    Zhang, Cheng; Jia, Haifeng; Wu, Weimin; Wang, Xicheng; Fang, Jinggui; Wang, Chen

    2015-12-10

    In grape cultivation, low temperature generally increases the expression of genes involved in synthesis of anthocyanin. In this study, multi-type structural analysis of the proteins encoded by five anthocyanin biosynthesis genes VvF3H, VvPAL, VvCHS3, VvCHS2 and VvLDOX, in addition to nine of their homologous genes revealed that proteins in grapevine shared a high similarity with that in kiwi, red orange and some other species in which the biosynthesis of anthocyanin significantly influenced by low temperature as proved by previous studies. Low temperature regulatory elements were also found in the promoter region of the grapevine genes VvCHS2, VvPAL and VvF3H. These findings indicate that the functions of anthocyanin biosynthesis genes in grapevine are conservative and might be sensitive to low temperature. In order to identify the specific expression patterns of the five anthocyanin biosynthesis genes and the changes of polyphenols, anthocyanins and flavonoids under low temperature stress. The transcription analysis of the five genes and the content of polyphenols, anthocyanins and flavonoids in grape skins were examined, by using Vitis vinifera L. cv. 'Yongyou 1' and 'Juxing' berries as experimental material and treated at 4°C and 25°C for 24h, 48 h, 72 h and 96 h. The results showed that low temperature greatly enhanced the expression of the five anthocyanin biosynthesis genes. Low temperature greatly slowed down the decomposition of polyphenol, anthocyanin, and flavonoid in grape skins. Our study also found that cv. 'Juxing' responded more sensitively to low temperature than cv. 'Yongyou 1'. All the findings would provide a basis for further study on the mechanism of anthocyanin biosynthesis under environmental stress.

  7. Conserved variable analysis of the marine boundary layer and air-sea exchange processes using BOBMEX-pilot data sets

    Indian Academy of Sciences (India)

    N V Sam; U C Mohanty; A N V Satyanarayana

    2000-06-01

    The present study is based on the observed features of the MBL (Marine Boundary Layer) during the Bay of Bengal and Monsoon Experiment (BOBMEX) - Pilot phase. Conserved Variable Analysis (CVA) of the conserved variables such as potential temperature, virtual potential temperature, equivalent potential temperature, saturation equivalent potential temperature and specific humidity were carried out at every point of upper air observation obtained on board ORV Sagar Kanya. The values are estimated up to a maximum of 4 km to cover the boundary layer. The Marine Boundary Layer Height is estimated from the conserved thermodynamic profiles. During the disturbed period when the convective activity is observed, the deeper boundary layers show double mixing line structures. An attempt is also made to study the oceanic heat budget using empirical models. The estimated short-wave radiation flux compared well with the observations.

  8. Streaming Support for Data Intensive Cloud-Based Sequence Analysis

    Directory of Open Access Journals (Sweden)

    Shadi A. Issa

    2013-01-01

    Full Text Available Cloud computing provides a promising solution to the genomics data deluge problem resulting from the advent of next-generation sequencing (NGS technology. Based on the concepts of “resources-on-demand” and “pay-as-you-go”, scientists with no or limited infrastructure can have access to scalable and cost-effective computational resources. However, the large size of NGS data causes a significant data transfer latency from the client’s site to the cloud, which presents a bottleneck for using cloud computing services. In this paper, we provide a streaming-based scheme to overcome this problem, where the NGS data is processed while being transferred to the cloud. Our scheme targets the wide class of NGS data analysis tasks, where the NGS sequences can be processed independently from one another. We also provide the elastream package that supports the use of this scheme with individual analysis programs or with workflow systems. Experiments presented in this paper show that our solution mitigates the effect of data transfer latency and saves both time and cost of computation.

  9. ANALYSIS AND COMPARISON OF EXISTING DECISION SUPPORT TECHNOLOGY

    Directory of Open Access Journals (Sweden)

    V. A. Rybak

    2016-01-01

    Full Text Available The article presents the results of an analytical review and comparison of the most common managerial decision support technologies: the analytic hierarchy method, neural networks, fuzzy set theory, genetic algorithms and neural-fuzzy modeling. The advantages and disadvantages of these approaches are shown. Determine the scope of their application. It is shown that the hierarchy analysis method works well with the full initial information, but due to the need for expert comparison of alternatives and the selection of evaluation criteria has a high proportion of subjectivity. For problems in the conditions of risk and uncertainty prediction seems reasonable use of the theory of fuzzy sets and neural networks. It is also considered technology collective decision applied both in the general election, and the group of experts. It reduces the time for conciliation meetings to reach a consensus by the preliminary analysis of all views submitted for the plane in the form of points. At the same time the consistency of opinion is determined by the distance between them.

  10. Urban life cycle analysis and the conservation of the urban fabric

    DEFF Research Database (Denmark)

    Algreen-Ussing, Gregers; Hassler, Uta; Kohler, Niklaus

    2004-01-01

    into consideration some new and emerging cultural aspects and to integrate them into adapted conservation procedures. This enlarged and more complex view on urban built heritage conservation problems has driven the SUIT project to propose introducing a new concept: the "active conservation". The definition...... of strategic objectives related to urban fragments heritage active-conservation and their management on long-term is a collective action that necessitates the ability to evaluate the quality of an urban fragment as a whole.......Urban projects, plans and other programmes falls under present Environmental Impact Assessment (EIA) directive as well as the Strategic Environmental Assessment (SEA) directive. There is a need to adopt more comprehensive understanding of urban built heritage, one that would enable taking...

  11. Analysis of regional banks' efforts to promote energy conservation among commercial customers. Task II

    Energy Technology Data Exchange (ETDEWEB)

    1979-10-30

    The study approach explored the hypothesis that regional banks can play an important role in disseminating energy conservation information to their commercial/industrial customers. The four phases of the study are described in detail. (MCW)

  12. Will farmers save water? A theoretical analysis of groundwater conservation policies

    Science.gov (United States)

    The development of agricultural irrigation systems has generated significant increases in food production and farm income. However, unplanned and unconstrained groundwater use could also cause serious consequences. To extend the economic life of groundwater, water conservation issues have become the...

  13. USE OF POPULATION VIABILITY ANALYSIS AND RESERVE SELECTION ALGORITHMS IN REGIONAL CONSERVATION PLANS

    Science.gov (United States)

    Current reserve selection algorithms have difficulty evaluating connectivity and other factorsnecessary to conserve wide-ranging species in developing landscapes. Conversely, population viability analyses may incorporate detailed demographic data but often lack sufficient spa...

  14. Supporting analysis and assessments quality metrics: Utility market sector

    Energy Technology Data Exchange (ETDEWEB)

    Ohi, J. [National Renewable Energy Lab., Golden, CO (United States)

    1996-10-01

    In FY96, NREL was asked to coordinate all analysis tasks so that in FY97 these tasks will be part of an integrated analysis agenda that will begin to define a 5-15 year R&D roadmap and portfolio for the DOE Hydrogen Program. The purpose of the Supporting Analysis and Assessments task at NREL is to provide this coordination and conduct specific analysis tasks. One of these tasks is to prepare the Quality Metrics (QM) for the Program as part of the overall QM effort at DOE/EERE. The Hydrogen Program one of 39 program planning units conducting QM, a process begun in FY94 to assess benefits/costs of DOE/EERE programs. The purpose of QM is to inform decisionmaking during budget formulation process by describing the expected outcomes of programs during the budget request process. QM is expected to establish first step toward merit-based budget formulation and allow DOE/EERE to get {open_quotes}most bang for its (R&D) buck.{close_quotes} In FY96. NREL coordinated a QM team that prepared a preliminary QM for the utility market sector. In the electricity supply sector, the QM analysis shows hydrogen fuel cells capturing 5% (or 22 GW) of the total market of 390 GW of new capacity additions through 2020. Hydrogen consumption in the utility sector increases from 0.009 Quads in 2005 to 0.4 Quads in 2020. Hydrogen fuel cells are projected to displace over 0.6 Quads of primary energy in 2020. In future work, NREL will assess the market for decentralized, on-site generation, develop cost credits for distributed generation benefits (such as deferral of transmission and distribution investments, uninterruptible power service), cost credits for by-products such as heat and potable water, cost credits for environmental benefits (reduction of criteria air pollutants and greenhouse gas emissions), compete different fuel cell technologies against each other for market share, and begin to address economic benefits, especially employment.

  15. Facility Safeguardability Analysis In Support of Safeguards-by-Design

    Energy Technology Data Exchange (ETDEWEB)

    Philip Casey Durst; Roald Wigeland; Robert Bari; Trond Bjornard; John Hockert; Michael Zentner

    2010-07-01

    methodology can be adapted for evaluating and assessing the safeguardability of nuclear facilities – both existing, as well as those still on the drawing board. The advantages of the Facility Safeguardability Analysis is that it would not only give the facility designer an analytical method for evaluating and assessing the safeguards measures and approaches for the prospective facility, but also the ability to optimize the design of the facility process for enhancing facility safeguardability. The following report explains the need for Facility Safeguardability Analysis and explains how it could be used in the Safeguards-by-Design, in support of the design and construction of nuclear facilities.

  16. Analysis of the Capacity of Wellspring Conservation in Limestone Areas of Jinan

    Institute of Scientific and Technical Information of China (English)

    Zhou Baohua; Li Daqiu

    2006-01-01

    Spring water in the city of Jinan comes from the limestone areas. Understanding the capacity of wellspring conservation is a critical point to resume the perennial spewing of the spring water. The vegetation,soil, and other natural and human aspects related to the conservation are studied by using the methods of geographic information systems (GIS), remote sensing (RS), and field investigation. In the end, suggestions for administration and planning as well as countermeasures are put forward.

  17. Comparative analysis reveals conserved protein phosphorylation networks implicated in multiple diseases

    DEFF Research Database (Denmark)

    Tan, Chris Soon Heng; Bodenmiller, Bernd; Pasculescu, Adrian

    2009-01-01

    Protein kinases enable cellular information processing. Although numerous human phosphorylation sites and their dynamics have been characterized, the evolutionary history and physiological importance of many signaling events remain unknown. Using target phosphoproteomes determined with a similar...... experimental and computational pipeline, we investigated the conservation of human phosphorylation events in distantly related model organisms (fly, worm, and yeast). With a sequence-alignment approach, we identified 479 phosphorylation events in 344 human proteins that appear to be positionally conserved over...

  18. A conceptual analysis of the application of tradable permits to biodiversity conservation.

    Science.gov (United States)

    Wissel, Silvia; Wätzold, Frank

    2010-04-01

    Tradable permits have been applied in many areas of environmental policy and may be a response to increasing calls for flexible conservation instruments that successfully conserve biodiversity while allowing for economic development. The idea behind applying tradable permits to conservation is that developers wishing to turn land to economic purposes, thereby destroying valuable habitat, may only do so if they submit a permit to the conservation agency showing that habitat of at least the equivalent ecological value is restored elsewhere. The developer himself does not need to carry out the restoration, but may buy a permit from a third party, thus allowing a market to emerge. Nevertheless, the application of tradable permits to biodiversity conservation is a complex issue because destroyed and restored habitats are likely to differ. There may be various trade-offs between the ecological requirements that destroyed and restored habitats be as similar as possible, and the need for a certain level of market activity to have a functioning trading system. The success of tradable permits as an instrument for reconciling the conflicts between economic development and conservation depends on the existence of certain economic, institutional, and ecological preconditions, for example, a functioning institutional framework, sufficient expert knowledge, and adequate monitoring and enforcement mechanisms.

  19. Analysis of the Improvement Methods for Equipment Maintenance Support

    Institute of Scientific and Technical Information of China (English)

    ZHANG Rui-chang; ZHAO Song-zheng

    2005-01-01

    According to military requirement, and based on the problems of equipment maintenance support methods in high-tech battles, each element supporting equipment maintenance is analyzed, and the methods for improving equipment maintenance are proposed.

  20. Seismic response analysis of a piping system subjected to multiple support excitations in a base isolated NPP building

    Energy Technology Data Exchange (ETDEWEB)

    Surh, Han-Bum [School of Mechanical Engineering, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon 440-746 (Korea, Republic of); Korea Atomic Energy Research Institute, 989-111 Daedeok-daero, Yuseong-gu, Daejeon 305-353 (Korea, Republic of); Ryu, Tae-Young; Park, Jin-Sung [School of Mechanical Engineering, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon 440-746 (Korea, Republic of); Ahn, Eun-Woo; Choi, Chul-Sun [Korea Electric Power Corporation Engineering & Construction Company, Inc., 2354 Yonggu-daero, Giheung-gu, Yongin 446-713 (Korea, Republic of); Koo, Ja Choon [School of Mechanical Engineering, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon 440-746 (Korea, Republic of); Choi, Jae-Boong [School of Mechanical Engineering, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon 440-746 (Korea, Republic of); SKKU Advanced Institute of Nanotechnology, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon 440-746 (Korea, Republic of); Kim, Moon Ki, E-mail: mkkim@me.skku.ac.kr [School of Mechanical Engineering, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon 440-746 (Korea, Republic of); SKKU Advanced Institute of Nanotechnology, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon 440-746 (Korea, Republic of)

    2015-10-15

    Highlights: • Piping system in the APR 1400 NPP with a base isolation design is studied. • Seismic response of piping system in base isolated building are investigated. • Stress classification method is examined for piping subjected to seismic loading. • Primary stress of piping is reduced due to base isolation design. • Substantial secondary stress is observed in the main steam piping. - Abstract: In this study, the stress response of the piping system in the advanced power reactor 1400 (APR 1400) with a base isolation design subjected to seismic loading is addressed. The piping system located between the auxiliary building with base isolation and the turbine building with a fixed base is considered since it can be subjected to substantial relative support movement during seismic events. First, the support responses with respect to the base characteristic are investigated to perform seismic analysis for multiple support excitations. Finite element analyses are performed to predict the piping stress response through various analysis methods such as the response spectrum, seismic support movement and time history method. To separately evaluate the inertial effect and support movement effect on the piping stress, the stress is decomposed into a primary and secondary stress using the proposed method. Finally, influences of the base isolation design on the piping system in the APR 1400 are addressed. The primary stress based on the inertial loading is effectively reduced in a base isolation design, whereas a considerable amount of secondary stress is generated in the piping system connecting a base isolated building with a fixed base building. It is also confirmed that both the response spectrum analysis and seismic support movement analysis provide more conservative estimations of the piping stress compared to the time history analysis.

  1. Mangrove and Freshwater Wetland Conservation Through Carbon Offsets: A Cost-Benefit Analysis for Establishing Environmental Policies

    Science.gov (United States)

    Vázquez-González, César; Moreno-Casasola, Patricia; Hernández, María Elizabeth; Campos, Adolfo; Espejel, Ileana; Fermán-Almada, José Luis

    2017-02-01

    Mexico has extensive coastal wetlands (4,243,137 ha), and one of its most important sites is the Alvarado Lagoon System, located in the Papaloapan River Basin on the Gulf of Mexico. The land cover dedicated to livestock and sugarcane has increased: by 25 % in 2005 and 50 % in 2010, with a loss of wetland vegetation and the carbon that it stores. We found that the Net Present Value of mangrove carbon offsets profit is equal to 5822.71, that of broad-leaved marshes is 7958.86, cattail marshes 5250.33, and forested wetlands 8369.41 per hectare, during a 30-year-carbonoffset contract. However, the opportunity cost from conserving wetland instead of growing sugarcane is positive according to REDD+ methodology, e.g., broad-leaved marsh conservation ranged from 6.73 to 20 USD/t CO2e, that of cattail marshes from 12.20 to 32.65 USD/t CO2e, and forested wetlands from 7.15 to 20.60 USD/t CO2e, whereas the opportunity cost between conservation and livestock was negative, it means that conservation is more profitable. The cost-benefit analysis for assessing investment projects from a governmental perspective is useful to determine the viability of conserving coastal wetlands through carbon offset credits. It also shows why in some areas it is not possible to conserve ecosystems due to the opportunity cost of changing from one economic activity (livestock and sugarcane) to carbon offsets for protecting wetlands. Furthermore, it allows for a comparison of carbon markets and assessment in terms of REDD+ and its methods for determining the social cost per ton of carbon avoided.

  2. Mangrove and Freshwater Wetland Conservation Through Carbon Offsets: A Cost-Benefit Analysis for Establishing Environmental Policies.

    Science.gov (United States)

    Vázquez-González, César; Moreno-Casasola, Patricia; Hernández, María Elizabeth; Campos, Adolfo; Espejel, Ileana; Fermán-Almada, José Luis

    2017-02-01

    Mexico has extensive coastal wetlands (4,243,137 ha), and one of its most important sites is the Alvarado Lagoon System, located in the Papaloapan River Basin on the Gulf of Mexico. The land cover dedicated to livestock and sugarcane has increased: by 25 % in 2005 and 50 % in 2010, with a loss of wetland vegetation and the carbon that it stores. We found that the Net Present Value of mangrove carbon offsets profit is equal to $5822.71, that of broad-leaved marshes is $7958.86, cattail marshes $5250.33, and forested wetlands $8369.41 per hectare, during a 30-year-carbonoffset contract. However, the opportunity cost from conserving wetland instead of growing sugarcane is positive according to REDD+ methodology, e.g., broad-leaved marsh conservation ranged from $6.73 to $20 USD/t CO2e, that of cattail marshes from $12.20 to $32.65 USD/t CO2e, and forested wetlands from $7.15 to $20.60 USD/t CO2e, whereas the opportunity cost between conservation and livestock was negative, it means that conservation is more profitable. The cost-benefit analysis for assessing investment projects from a governmental perspective is useful to determine the viability of conserving coastal wetlands through carbon offset credits. It also shows why in some areas it is not possible to conserve ecosystems due to the opportunity cost of changing from one economic activity (livestock and sugarcane) to carbon offsets for protecting wetlands. Furthermore, it allows for a comparison of carbon markets and assessment in terms of REDD+ and its methods for determining the social cost per ton of carbon avoided.

  3. Combination of material flow analysis and substance flow analysis: a powerful approach for decision support in waste management.

    Science.gov (United States)

    Stanisavljevic, Nemanja; Brunner, Paul H

    2014-08-01

    The novelty of this paper is the demonstration of the effectiveness of combining material flow analysis (MFA) with substance flow analysis (SFA) for decision making in waste management. Both MFA and SFA are based on the mass balance principle. While MFA alone has been applied often for analysing material flows quantitatively and hence to determine the capacities of waste treatment processes, SFA is more demanding but instrumental in evaluating the performance of a waste management system regarding the goals "resource conservation" and "environmental protection". SFA focuses on the transformations of wastes during waste treatment: valuable as well as hazardous substances and their transformations are followed through the entire waste management system. A substance-based approach is required because the economic and environmental properties of the products of waste management - recycling goods, residues and emissions - are primarily determined by the content of specific precious or harmful substances. To support the case that MFA and SFA should be combined, a case study of waste management scenarios is presented. For three scenarios, total material flows are quantified by MFA, and the mass flows of six indicator substances (C, N, Cl, Cd, Pb, Hg) are determined by SFA. The combined results are compared to the status quo in view of fulfilling the goals of waste management. They clearly point out specific differences between the chosen scenarios, demonstrating potentials for improvement and the value of the combination of MFA/SFA for decision making in waste management.

  4. Quantitative XPS analysis of silica-supported Cu Co oxides

    Science.gov (United States)

    Cesar, Deborah V.; Peréz, Carlos A.; Schmal, Martin; Salim, Vera Maria M.

    2000-04-01

    Copper-cobalt oxides with Cu/Co=5:5, 15:15 and 35:35 bulk ratio have been prepared by deposition-precipitation method at constant pH from copper and cobalt nitrate solutions. Different oxides were obtained by decomposition of the precursors at 673 K for 7 h in air and analyzed by X-ray diffraction (XRD), transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS). XRD data showed the formation of different oxide phases; for the bulk atomic ratio of 15Cu:15Co, a phase containing Cu and Co with spinel-like structure was observed, while the other bimetallic oxides presented CuO and Co 3O 4 as distinct phases. The XPS qualitative analysis has shown that all samples exhibited Cu 2+ and Co 3+ species at the surface. The Cu-Co spinel presented a displacement in Cu 2p binding energy value. A mathematical model was proposed from relative intensity ratios, which allowed the determination of the oxide particle thickness and the fraction of coverage at the support. This model described accurately the system and showed that cobalt improved the copper dispersion.

  5. Numerical analysis of pile lateral behavior of pile supported embankment

    Institute of Scientific and Technical Information of China (English)

    荆志东; 刘力; 郑刚; 姜岩

    2008-01-01

    A finite difference numerical method was adopted to evaluate the pile lateral behavior of pile supported embankment. A published case history was used to verify the proposed methodology. By simulating the case history, the determination of parameters needed were verified. Then three embankments constructed on different ground conditions with different soil-pile relative stiffnesses were analyzed to study pile lateral behaviors including pile deflection and bending moment. The results show that pile deflections and bending moments induced by soil lateral deformation and embankment vertical load are different for piles at different positions under the same embankment. The relative stiffness between pile and soil affected by the properties of different reinforcing piles such as concrete pile and deep mixing method pile exert important effects on the pile lateral behavior and the pile’s failure modes. Consequently, it is necessary to consider the different piles lateral behaviors and possible failure modes at different positions and the different piles proprieties with different reinforcing methods in the embankment stability analysis.

  6. Support for victims of crime: Analysis of the VDS info and victim support service in 2010

    Directory of Open Access Journals (Sweden)

    Ćopić Sanja

    2011-01-01

    Full Text Available VDS info and victim support service is a victim support service, which was established in 2003 within the Victimology Society of Serbia. The service provides emotional support, information and, if necessary, referral to other relevant services, as well as witness support. The target group of the service are direct and indirect victims of all forms of crime, of both sexes, regardless of any personal characteristics. In addition, support is provided to victims in court, as well as to women victims of violence who are in prison. In most cases victim support is provided by volunteers who are trained to work with victims of crime. This paper analyzes the work of the service in 2010. Special attention is paid to the problems of workplace violence and domestic violence, which are the most common reasons for contacting the service. The aim of the paper is to present the work of the service in the past year, as well as to highlight the trends observed in comparison to the previous period.

  7. Augustine Band of Cahuilla Indians Energy Conservation and Options Analysis - Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Paul Turner

    2008-07-11

    The Augustine Band of Cahuilla Indians was awarded a grant through the Department of Energy First Steps program in June of 2006. The primary purpose of the grant was to enable the Tribe to develop energy conservation policies and a strategy for alternative energy resource development. All of the work contemplated by the grant agreement has been completed and the Tribe has begun implementing the resource development strategy through the construction of a 1.0 MW grid-connected photovoltaic system designed to offset a portion of the energy demand generated by current and projected land uses on the Tribe’s Reservation. Implementation of proposed energy conservation policies will proceed more deliberately as the Tribe acquires economic development experience sufficient to evaluate more systematically the interrelationships between conservation and its economic development goals.

  8. Analysis to develop a program for energy conservation in irrigated agriculture

    Energy Technology Data Exchange (ETDEWEB)

    Cone, B.W.; Brix, V.L.; Eakin, D.E.; Laughlin, B.M.

    1978-09-01

    It is estimated by the FEA that 0.26 quadrillion Btus of energy is annually required to irrigate crops in the USA. The development of a DOE program for energy conservation in irrigation is described. Information is included on: studies of how this energy consumption can be reduced and by how much; engineering and economic studies of irrigation equipment and methods; proposals for improving the efficiency of pumps and prime movers; projects selected for demonstrating irrigation energy conservation; and recommendations for further research. (LCL)

  9. [New paradigm for soil and water conservation: a method based on watershed process modeling and scenario analysis].

    Science.gov (United States)

    Zhu, A-Xing; Chen, La-Jiao; Qin, Cheng-Zhi; Wang, Ping; Liu, Jun-Zhi; Li, Run-Kui; Cai, Qiang-Guo

    2012-07-01

    With the increase of severe soil erosion problem, soil and water conservation has become an urgent concern for sustainable development. Small watershed experimental observation is the traditional paradigm for soil and water control. However, the establishment of experimental watershed usually takes long time, and has the limitations of poor repeatability and high cost. Moreover, the popularization of the results from the experimental watershed is limited for other areas due to the differences in watershed conditions. Therefore, it is not sufficient to completely rely on this old paradigm for soil and water loss control. Recently, scenario analysis based on watershed modeling has been introduced into watershed management, which can provide information about the effectiveness of different management practices based on the quantitative simulation of watershed processes. Because of its merits such as low cost, short period, and high repeatability, scenario analysis shows great potential in aiding the development of watershed management strategy. This paper elaborated a new paradigm using watershed modeling and scenario analysis for soil and water conservation, illustrated this new paradigm through two cases for practical watershed management, and explored the future development of this new soil and water conservation paradigm.

  10. Identification of miR414 and expression analysis of conserved miRNAs from Stevia rebaudiana.

    Science.gov (United States)

    Guleria, Praveen; Yadav, Sudesh Kumar

    2011-12-01

    MicroRNAs (miRNAs) usually contain 19-24 nucleotides and have been identified as important eukaryotic gene regulators. Applications of various computational approaches have simplified the task by predicting miRNAs from available sequence data sources. In this study, we identified a conserved miR414 from a computational analysis of EST sequence data available from Stevia rebaudiana. In addition, we also identified six conserved miRNAs namely miR169, miR319, miR414, miR164, miR167 and miR398 using stem-loop RT-PCR analysis. Hence, miR414 was commonly identified using both methods. The expression analysis of these miRNAs documented their roles in growth and development of Stevia. Furthermore, the detected miRNAs were found to target genes involved in plant growth, development, metabolism and signal transduction. This is the first study reporting these conserved miRNAs and their expression in Stevia.

  11. Quantitative ultrasound texture analysis for clinical decision making support

    Science.gov (United States)

    Wu, Jie Ying; Beland, Michael; Konrad, Joseph; Tuomi, Adam; Glidden, David; Grand, David; Merck, Derek

    2015-03-01

    We propose a general ultrasound (US) texture-analysis and machine-learning framework for detecting the presence of disease that is suitable for clinical application across clinicians, disease types, devices, and operators. Its stages are image selection, image filtering, ROI selection, feature parameterization, and classification. Each stage is modular and can be replaced with alternate methods. Thus, this framework is adaptable to a wide range of tasks. Our two preliminary clinical targets are hepatic steatosis and adenomyosis diagnosis. For steatosis, we collected US images from 288 patients and their pathology-determined values of steatosis (%) from biopsies. Two radiologists independently reviewed all images and identified the region of interest (ROI) most representative of the hepatic echotexture for each patient. To parameterize the images into comparable quantities, we filter the US images at multiple scales for various texture responses. For each response, we collect a histogram of pixel features within the ROI, and parameterize it as a Gaussian function using its mean, standard deviation, kurtosis, and skew to create a 36-feature vector. Our algorithm uses a support vector machine (SVM) for classification. Using a threshold of 10%, we achieved 72.81% overall accuracy, 76.18% sensitivity, and 65.96% specificity in identifying steatosis with leave-ten-out cross-validation (p<0.0001). Extending this framework to adenomyosis, we identified 38 patients with MR-confirmed findings of adenomyosis and previous US studies and 50 controls. A single rater picked the best US-image and ROI for each case. Using the same processing pipeline, we obtained 76.14% accuracy, 86.00% sensitivity, and 63.16% specificity with leave-one-out cross-validation (p<0.0001).

  12. EST analysis in Ginkgo biloba: an assessment of conserved developmental regulators and gymnosperm specific genes

    Directory of Open Access Journals (Sweden)

    Runko Suzan J

    2005-10-01

    Full Text Available Abstract Background Ginkgo biloba L. is the only surviving member of one of the oldest living seed plant groups with medicinal, spiritual and horticultural importance worldwide. As an evolutionary relic, it displays many characters found in the early, extinct seed plants and extant cycads. To establish a molecular base to understand the evolution of seeds and pollen, we created a cDNA library and EST dataset from the reproductive structures of male (microsporangiate, female (megasporangiate, and vegetative organs (leaves of Ginkgo biloba. Results RNA from newly emerged male and female reproductive organs and immature leaves was used to create three distinct cDNA libraries from which 6,434 ESTs were generated. These 6,434 ESTs from Ginkgo biloba were clustered into 3,830 unigenes. A comparison of our Ginkgo unigene set against the fully annotated genomes of rice and Arabidopsis, and all available ESTs in Genbank revealed that 256 Ginkgo unigenes match only genes among the gymnosperms and non-seed plants – many with multiple matches to genes in non-angiosperm plants. Conversely, another group of unigenes in Gingko had highly significant homology to transcription factors in angiosperms involved in development, including MADS box genes as well as post-transcriptional regulators. Several of the conserved developmental genes found in Ginkgo had top BLAST homology to cycad genes. We also note here the presence of ESTs in G. biloba similar to genes that to date have only been found in gymnosperms and an additional 22 Ginkgo genes common only to genes from cycads. Conclusion Our analysis of an EST dataset from G. biloba revealed genes potentially unique to gymnosperms. Many of these genes showed homology to fully sequenced clones from our cycad EST dataset found in common only with gymnosperms. Other Ginkgo ESTs are similar to developmental regulators in higher plants. This work sets the stage for future studies on Ginkgo to better understand seed and

  13. Ohio Aquatic Gap Analysis-An Assessment of the Biodiversity and Conservation Status of Native Aquatic Animal Species

    Science.gov (United States)

    Covert, S. Alex; Kula, Stephanie P.; Simonson, Laura A.

    2007-01-01

    The goal of the GAP Analysis Program is to keep common species common by identifying those species and habitats that are not yet adequately represented in the existing matrix of conservation lands. The Gap Analysis Program (GAP) is sponsored by the Biological Resources Discipline of the U.S. Geological Survey (USGS). The Ohio Aquatic GAP (OH-GAP) is a pilot project that is applying the GAP concept to aquatic-specifically, riverine-data. The mission of GAP is to provide regional assessments of the conservation status of native animal species and to facilitate the application of this information to land-management activities. OH-GAP accomplished this through * mapping aquatic habitat types, * mapping the predicted distributions of fish, crayfish, and bivalves, * documenting the presence of aquatic species in areas managed for conservation, * providing GAP results to the public, planners, managers, policy makers, and researchers, and * building cooperation with multiple organizations to apply GAP results to state and regional management activities. Gap analysis is a coarse-scale assessment of aquatic biodiversity and conservation; the goal is to identify gaps in the conservation of native aquatic species. It is not a substitute for biological field studies and monitoring programs. Gap analysis was conducted for the continuously flowing streams in Ohio. Lakes, reservoirs, wetlands, and the Lake Erie islands were not included in this analysis. The streams in Ohio are in the Lake Erie and Ohio River watersheds and pass through six of the level III ecoregions defined by Omernik: the Eastern Corn Belt Plains, Southern Michigan/Northern Indiana Drift Plains, Huron/Erie Lake Plain, Erie Drift Plains, Interior Plateau, and the Western Allegheny Plateau. To characterize the aquatic habitats available to Ohio fish, crayfish, and bivalves, a classification system needed to be developed and mapped. The process of classification includes delineation of areas of relative

  14. The U.S. Geological Survey Bird Banding Laboratory: an integrated scientific program supporting research and conservation of North American birds

    Science.gov (United States)

    Smith, Gregory J.

    2013-01-01

    The U.S. Geological Survey (USGS) Bird Banding Laboratory (BBL) was established in 1920 after ratification of the Migratory Bird Treaty Act with the United Kingdom in 1918. During World War II, the BBL was moved from Washington, D.C., to what is now the USGS Patuxent Wildlife Research Center (PWRC). The BBL issues permits and bands to permittees to band birds, records bird band recoveries or encounters primarily through telephone and Internet reporting, and manages more than 72 million banding records and more than 4.5 million records of encounters using state-of-the-art technologies. Moreover, the BBL also issues bands and manages banding and encounter data for the Canadian Bird Banding Office (BBO). Each year approximately 1 million bands are shipped from the BBL to banders in the United States and Canada, and nearly 100,000 encounter reports are entered into the BBL systems. Banding data are essential for regulatory programs, especially migratory waterfowl harvest regulations. The USGS BBL works closely with the U.S. Fish and Wildlife Service (USFWS) to develop regulations for the capture, handling, banding, and marking of birds. These regulations are published in the Code of Federal Regulations (CFR). In 2006, the BBL and the USFWS Division of Migratory Bird Management (DMBM) began a comprehensive revision of the banding regulations. The bird banding community has three major constituencies: Federal and State agency personnel involved in the management and conservation of bird populations that include the Flyway Councils, ornithological research scientists, and avocational banders. With increased demand for banding activities and relatively constant funding, a Federal Advisory Committee (Committee) was chartered and reviewed the BBL program in 2005. The final report of the Committee included six major goals and 58 specific recommendations, 47 of which have been addressed by the BBL. Specifically, the Committee recommended the BBL continue to support science

  15. Structure-sequence based analysis for identification of conserved regions in proteins

    Science.gov (United States)

    Zemla, Adam T; Zhou, Carol E; Lam, Marisa W; Smith, Jason R; Pardes, Elizabeth

    2013-05-28

    Disclosed are computational methods, and associated hardware and software products for scoring conservation in a protein structure based on a computationally identified family or cluster of protein structures. A method of computationally identifying a family or cluster of protein structures in also disclosed herein.

  16. Stability analysis of explicit entropy viscosity methods for non-linear scalar conservation equations

    KAUST Repository

    Bonito, Andrea

    2013-10-03

    We establish the L2-stability of an entropy viscosity technique applied to nonlinear scalar conservation equations. First-and second-order explicit time-stepping techniques using continuous finite elements in space are considered. The method is shown to be stable independently of the polynomial degree of the space approximation under the standard CFL condition. © 2013 American Mathematical Society.

  17. Preliminary analysis of a clinical trial for threedimensional conformal radiation therapy after conservative surgery

    Institute of Scientific and Technical Information of China (English)

    Hui Yao; Jinlan Gong; Li Li; Yun Wang; Xiaofeng Wu; Kezhu Hou

    2012-01-01

    Objective: The aim of this study was to evaluate the efficacy, complications and cosmetic results of three-dimensional conformal radiation therapy for early breast cancer after conservative surgery. Methods: Among 80 patients, 44 were treated by modified radical mastectomy followed by adjuvant radiotherapy (modified radical mastectomy, MMT), 36 were treated with breast conservative surgery with adjuvant irradiation [breast-conservation therapy (BCT)]. Tangential fields were used to deliver 6 MV X-ray beams to a total dose of 50 Gy. Another 16 Gy was added to the tumor bed with 6-9 MeV electron beams for BCT. Results: In MMT group, the local control, metastasis-free and death were 41, 41 and 1 respectively; in BCT group, the local control, metastasis-free and death were 35, 35 and 0. The difference of the above two indicators between the two groups showeed no statistical insignificance (P > 0. 05). In MMT group, 32 patients suffer radiation dermatitis above 2-level, 12 patients suffer radiation pneumonia, and 10 patients suffer edema of illness-side upper extremity; in BCT group, the above indicators were only 6, 2 and 1 respectively. Three months, six months and one year after radiation therapy, 90%, 92% and 95% patients were assessed as excellence in fine cosmetic state in BCT group. Conclusion: The effects of threedimensional conformal radiation therapy after conservative surgery are the same as that of modified radical mastectomy, while the former has better cosmetic results and lower radiation therapy induced complications.

  18. Impacts of project attributes on investment preferences : an empirical cluster analysis of energy conservation investment attitudes

    NARCIS (Netherlands)

    Meisner, Jan; Gillissen, Merlijn

    1994-01-01

    Investment attitude refers to the way managements of firms value attributes of investmentproposals and weigh them in their final appraisal. It seems that among firms in the Netherlands an investment attitude exists that hinders theimplementation of energy conservation projects. Using paired comparis

  19. AFLP Analysis of Enset Clonal Diversity in South and Southwestern Ethiopia for Conservation

    NARCIS (Netherlands)

    Negash, A.; Tsegaye, A.; Treuren, van R.; Visser, B.

    2002-01-01

    Enset [Ensete ventricosum (Welw.) Cheesman] is a major multi-purpose crop in Ethiopia, which has been identified as the center of origin and diversity of enset. During the last decades, the local farming systems in which enset is maintained have become endangered. Conservation of clonally propagated

  20. Cost-benefit analysis of conservation agriculture implementation in Syrdarya province of Uzbekistan

    NARCIS (Netherlands)

    Daujanov, Azizbek; Groeneveld, R.A.; Pulatov, Alim; Heijman, W.J.M.

    2016-01-01

    Most irrigated lands of Central Asia suffer from land degradation, and unsustainable Agricultural practices are one of the factors contributing to land degradation. Conservation agriculture (CA) is seen as a way to mitigate land degradation and rationalize resource use. The aim of this article is to

  1. Conservation priorities in a biodiversity hotspot: analysis of narrow endemic plant species in New Caledonia.

    Directory of Open Access Journals (Sweden)

    Adrien S Wulff

    Full Text Available New Caledonia is a global biodiversity hotspot facing extreme environmental degradation. Given the urgent need for conservation prioritisation, we have made a first-pass quantitative assessment of the distribution of Narrow Endemic Species (NES in the flora to identify species and sites that are potentially important for conservation action. We assessed the distributional status of all angiosperm and gymnosperm species using data from taxonomic descriptions and herbarium samples. We characterised species as being NES if they occurred in 3 or fewer locations. In total, 635 of the 2930 assessed species were classed as NES, of which only 150 have been subjected to the IUCN conservation assessment. As the distributional patterns of un-assessed species from one or two locations correspond well with assessed species which have been classified as Critically Endangered or Endangered respectively, we suggest that our distributional data can be used to prioritise species for IUCN assessment. We also used the distributional data to produce a map of "Hotspots of Plant Narrow Endemism" (HPNE. Combined, we used these data to evaluate the coincidence of NES with mining activities (a major source of threat on New Caledonia and also areas of conservation protection. This is to identify species and locations in most urgent need of further conservation assessment and subsequent action. Finally, we grouped the NES based on the environments they occurred in and modelled the habitat distribution of these groups with a Maximum Entropy Species Distribution Model (MaxEnt. The NES were separable into three different groups based primarily on geological differences. The distribution of the habitat types for each group coincide partially with the HPNE described above and also indicates some areas which have high habitat suitability but few recorded NES. Some of these areas may represent under-sampled hotspots of narrow endemism and are priorities for further field work.

  2. Conservation priorities in a biodiversity hotspot: analysis of narrow endemic plant species in New Caledonia.

    Science.gov (United States)

    Wulff, Adrien S; Hollingsworth, Peter M; Ahrends, Antje; Jaffré, Tanguy; Veillon, Jean-Marie; L'Huillier, Laurent; Fogliani, Bruno

    2013-01-01

    New Caledonia is a global biodiversity hotspot facing extreme environmental degradation. Given the urgent need for conservation prioritisation, we have made a first-pass quantitative assessment of the distribution of Narrow Endemic Species (NES) in the flora to identify species and sites that are potentially important for conservation action. We assessed the distributional status of all angiosperm and gymnosperm species using data from taxonomic descriptions and herbarium samples. We characterised species as being NES if they occurred in 3 or fewer locations. In total, 635 of the 2930 assessed species were classed as NES, of which only 150 have been subjected to the IUCN conservation assessment. As the distributional patterns of un-assessed species from one or two locations correspond well with assessed species which have been classified as Critically Endangered or Endangered respectively, we suggest that our distributional data can be used to prioritise species for IUCN assessment. We also used the distributional data to produce a map of "Hotspots of Plant Narrow Endemism" (HPNE). Combined, we used these data to evaluate the coincidence of NES with mining activities (a major source of threat on New Caledonia) and also areas of conservation protection. This is to identify species and locations in most urgent need of further conservation assessment and subsequent action. Finally, we grouped the NES based on the environments they occurred in and modelled the habitat distribution of these groups with a Maximum Entropy Species Distribution Model (MaxEnt). The NES were separable into three different groups based primarily on geological differences. The distribution of the habitat types for each group coincide partially with the HPNE described above and also indicates some areas which have high habitat suitability but few recorded NES. Some of these areas may represent under-sampled hotspots of narrow endemism and are priorities for further field work.

  3. Identification of evolutionarily conserved Momordica charantia microRNAs using computational approach and its utility in phylogeny analysis.

    Science.gov (United States)

    Thirugnanasambantham, Krishnaraj; Saravanan, Subramanian; Karikalan, Kulandaivelu; Bharanidharan, Rajaraman; Lalitha, Perumal; Ilango, S; HairulIslam, Villianur Ibrahim

    2015-10-01

    Momordica charantia (bitter gourd, bitter melon) is a monoecious Cucurbitaceae with anti-oxidant, anti-microbial, anti-viral and anti-diabetic potential. Molecular studies on this economically valuable plant are very essential to understand its phylogeny and evolution. MicroRNAs (miRNAs) are conserved, small, non-coding RNA with ability to regulate gene expression by bind the 3' UTR region of target mRNA and are evolved at different rates in different plant species. In this study we have utilized homology based computational approach and identified 27 mature miRNAs for the first time from this bio-medically important plant. The phylogenetic tree developed from binary data derived from the data on presence/absence of the identified miRNAs were noticed to be uncertain and biased. Most of the identified miRNAs were highly conserved among the plant species and sequence based phylogeny analysis of miRNAs resolved the above difficulties in phylogeny approach using miRNA. Predicted gene targets of the identified miRNAs revealed their importance in regulation of plant developmental process. Reported miRNAs held sequence conservation in mature miRNAs and the detailed phylogeny analysis of pre-miRNA sequences revealed genus specific segregation of clusters.

  4. Clinical decision support tools: analysis of online drug information databases

    OpenAIRE

    Seamon Matthew J; Polen Hyla H; Marsh Wallace A; Clauson Kevin A; Ortiz Blanca I

    2007-01-01

    Abstract Background Online drug information databases are used to assist in enhancing clinical decision support. However, the choice of which online database to consult, purchase or subscribe to is likely made based on subjective elements such as history of use, familiarity, or availability during professional training. The purpose of this study was to evaluate clinical decision support tools for drug information by systematically comparing the most commonly used online drug information datab...

  5. Integrating habitat restoration and fisheries management : A small-scale case-study to support EEL conservation at the global scale

    Directory of Open Access Journals (Sweden)

    Ciccotti E.

    2013-02-01

    Full Text Available The aim of this work was to develop a methodological framework for the management of local eel stocks that integrates habitat restoration with optimal fishery management. The Bolsena lake (Viterbo, Italy and its emissary, the river Marta, were taken as a reference system. The river flows in the Mediterranean sea but its course is fragmented by a number of dams built in the past century preventing eel migration from and to the sea. Eel fishery in the Bolsena lake is thus sustained by periodic stocking of glass eels caught at the Marta river estuary. A detailed demographic model was applied to simulate fishery yields and potential spawner escapement under different recruitment and management scenarios. It was estimated that the high exploitation rates occurring in the nineties reduced the potential spawner escapement from the Bolsena lake to less than 1 t; under current harvesting rates, the potential spawner escapement is estimated in about 12 t while in pristine conditions (i.e. high recruitment and no fishing estimated spawner escapement is about 21 t. This analysis thus showed that current fishery management would comply with the 40% spawner escapement requirement of the EU regulation 1100/2007 if the connections between the Bolsena lake emissary and the sea were fully re-established. This confirms the opportunity of an integrated approach to management at the catchment area level scale for eel populations, that shall hopefully contribute to the conservation of the global stock.

  6. Conservation properties of the trapezoidal rule in linear time domain analysis of acoustics and structures

    CERN Document Server

    Nandy, Arup Kumar

    2014-01-01

    The trapezoidal rule, which is a special case of the Newmark family of algorithms, is one of the most widely used methods for transient hyperbolic problems. In this work, we show that this rule conserves linear and angular momenta and energy in the case of undamped linear elastodynamics problems, and an `energy-like measure' in the case of undamped acoustic problems. These conservation properties, thus, provide a rational basis for using this algorithm. In linear elastodynamics problems, variants of the trapezoidal rule that incorporate `high-frequency' dissipation are often used, since the higher frequencies, which are not approximated properly by the standard displacement-based approach, often result in unphysical behavior. Instead of modifying the trapezoidal algorithm, we propose using a hybrid finite element framework for constructing the stiffness matrix. Hybrid finite elements, which are based on a two-field variational formulation involving displacement and stresses, are known to approximate the eigen...

  7. Analysis of Energy Consumption and Energy Conservation Measures for RFCCU at Shengli Petrochemical Company

    Institute of Scientific and Technical Information of China (English)

    Li Ning; Xu Zhenling

    2006-01-01

    This article introduces a string of energy conservation measures adopted over the past several years by the RFCC unit at Shengli Petrochemical Complex, including the optimization of feedstock properties, the adoption of high-efficiency atomizing nozzles, the revamp of CO boiler, the atomization by means of dry gas, the post-burning of flue gas as well as the application of frequency converting machines and pumps, resulting in ideal effects. The energy consumption of the RFCC unit was gradually decreased to 2984.25 MJ/t from the original level of 3716.99 MJ/t. After comparing basic energy consumption values with actual consumption values, the authors have set forward measures for further energy conservation, such as the recovery of low-temperature excess heat contained in oil/gas streams exiting from the fractionation tower top, addition of the fourth cyclone, delivery of hot oil slurry, and heat tracing with hot water.

  8. Symmetry Analysis and Conservation Laws for the Hunter-Saxton Equation

    Institute of Scientific and Technical Information of China (English)

    Mehdi Nadjafikhah; Fatemeh Ahangari

    2013-01-01

    In this paper,the problem of determining the most generalLie point symmetries group and conservation laws of a well known nonlinear hyperbolic PDE in mathematical physics called the Hunter-Saxton equation (HSE) is analyzed.By applying the basic Lie symmetry method for the HSE,the classical Lie point symmetry operators are obtained.Also,the algebraic structure of the Lie algebra of symmetries is discussed and an optimal system of one-dimensional subalgebras of the HSE symmetry algebra which creates the preliminary classification of group invariant solutions is constructed.Particularly,the Lie invariants as well as similarity reduced equations corresponding to infinitesimal symmetries are obtained.Mainly,the conservation laws of the HSE are computed via three different methods including Boyer's generalization of Noether's theorem,first homotopy method and second homotopy method.

  9. Intensity Conserving Spline Interpolation (ICSI): A New Tool for Spectroscopic Analysis

    CERN Document Server

    Klimchuk, James A; Tripathi, Durgesh

    2015-01-01

    The detailed shapes of spectral line profiles provide valuable information about the emitting plasma, especially when the plasma contains an unresolved mixture of velocities, temperatures, and densities. As a result of finite spectral resolution, the intensity measured by a spectrometer is the average intensity across a wavelength bin of non-zero size. It is assigned to the wavelength position at the center of the bin. However, the actual intensity at that discrete position will be different if the profile is curved, as it invariably is. Standard fitting routines (spline, Gaussian, etc.) do not account for this difference, and this can result in significant errors when making sensitive measurements. Detection of asymmetries in solar coronal emission lines is one example. Removal of line blends is another. We have developed an iterative procedure called Intensity Conserving Spline Interpolation (ICSI) that corrects for this effect. As its name implies, it conserves the observed intensity within each wavelength...

  10. Invariance analysis and conservation laws of the wave equation on Vaidya manifolds

    Indian Academy of Sciences (India)

    R Narain; A H Kara

    2011-09-01

    In this paper we discuss symmetries of classes of wave equations that arise as a consequence of some Vaidya metrics. We show how the wave equation is altered by the underlying geometry. In particular, a range of consequences on the form of the wave equation, the symmetries and number of conservation laws, inter alia, are altered by the manifold on which the model wave rests. We find Lie and Noether point symmetries of the corresponding wave equations and give some reductions. Some interesting physical conclusions relating to conservation laws such as energy, linear and angular momenta are also determined. We also present some interesting comparisons with the standard wave equations on a flat geometry. Finally, we pursue the existence of higher-order variational symmetries of equations on nonflat manifolds.

  11. Exploring the communication of social support within virtual communities: a content analysis of messages posted to an online HIV/AIDS support group.

    Science.gov (United States)

    Mo, Phoenix K H; Coulson, Neil S

    2008-06-01

    The present study examined the nature of social support exchanged within an online HIV/AIDS support group. Content analysis was conducted with reference to five types of social support (information support, tangible assistance, esteem support, network support, and emotional support) on 85 threads (1,138 messages). Our analysis revealed that many of the messages offered informational and emotional support, followed by esteem support and network support, with tangible assistance the least frequently offered. Results suggest that this online support group is a popular forum through which individuals living with HIV/AIDS can offer social support. Our findings have implications for health care professionals who support individuals living with HIV/AIDS.

  12. Recoverability analysis for modified compressive sensing with partially known support.

    Directory of Open Access Journals (Sweden)

    Jun Zhang

    Full Text Available The recently proposed modified-compressive sensing (modified-CS, which utilizes the partially known support as prior knowledge, significantly improves the performance of recovering sparse signals. However, modified-CS depends heavily on the reliability of the known support. An important problem, which must be studied further, is the recoverability of modified-CS when the known support contains a number of errors. In this letter, we analyze the recoverability of modified-CS in a stochastic framework. A sufficient and necessary condition is established for exact recovery of a sparse signal. Utilizing this condition, the recovery probability that reflects the recoverability of modified-CS can be computed explicitly for a sparse signal with [Formula: see text] nonzero entries. Simulation experiments have been carried out to validate our theoretical results.

  13. Organizational analysis of three community support program models.

    Science.gov (United States)

    Reinke, B; Greenley, J R

    1986-06-01

    Little attention has been paid to the organizational and administrative characteristics of effective community support programs for the chronic mentally ill. The authors analyzed three successful support programs in Wisconsin that employ three different models of service delivery: one provides services through caseworkers who carry specialized caseloads, another through local nonprofessionals who work with a centrally located program coordinator, and the third through a team of various mental health workers. Each program has tailored its organizational process to suit the types of clients it sees, the size of its catchment area, and the availability of other professional resources. The interrelated strengths and weaknesses of each model are discussed.

  14. Systems and Trans-System Level Analysis Identifies Conserved Iron Deficiency Responses in the Plant Lineage[W][OA

    Science.gov (United States)

    Urzica, Eugen I.; Casero, David; Yamasaki, Hiroaki; Hsieh, Scott I.; Adler, Lital N.; Karpowicz, Steven J.; Blaby-Haas, Crysten E.; Clarke, Steven G.; Loo, Joseph A.; Pellegrini, Matteo; Merchant, Sabeeha S.

    2012-01-01

    We surveyed the iron nutrition-responsive transcriptome of Chlamydomonas reinhardtii using RNA-Seq methodology. Presumed primary targets were identified in comparisons between visually asymptomatic iron-deficient versus iron-replete cells. This includes the known components of high-affinity iron uptake as well as candidates for distributive iron transport in C. reinhardtii. Comparison of growth-inhibited iron-limited versus iron-replete cells revealed changes in the expression of genes in chloroplastic oxidative stress response pathways, among hundreds of other genes. The output from the transcriptome was validated at multiple levels: by quantitative RT-PCR for assessing the data analysis pipeline, by quantitative proteomics for assessing the impact of changes in RNA abundance on the proteome, and by cross-species comparison for identifying conserved or universal response pathways. In addition, we assessed the functional importance of three target genes, VITAMIN C 2 (VTC2), MONODEHYDROASCORBATE REDUCTASE 1 (MDAR1), and CONSERVED IN THE GREEN LINEAGE AND DIATOMS 27 (CGLD27), by biochemistry or reverse genetics. VTC2 and MDAR1, which are key enzymes in de novo ascorbate synthesis and ascorbate recycling, respectively, are likely responsible for the 10-fold increase in ascorbate content of iron-limited cells. CGLD27/At5g67370 is a highly conserved, presumed chloroplast-localized pioneer protein and is important for growth of Arabidopsis thaliana in low iron. PMID:23043051

  15. Prolonged conservative care versus early surgery in patients with sciatica from lumbar disc herniation : cost utility analysis alongside a randomised controlled trial

    NARCIS (Netherlands)

    Hout, van den W.B.; Peul, W.C.; Koes, B.W.; Brand, R.; Kievit, J.; Thomeer, R.T.W.M.

    2008-01-01

    Objective: To determine whether the faster recovery after early surgery for sciatica compared with prolonged conservative care is attained at reasonable costs. Design: Cost utility analysis alongside a randomised controlled trial. Setting: Nine Dutch hospitals. Participants: 283 patients with sciati

  16. Prolonged conservative care versus early surgery in patients with sciatica from lumbar disc herniation: cost utility analysis alongside a randomised controlled trial.

    NARCIS (Netherlands)

    Hout, W.B. van den; Peul, W.C.; Koes, B.W.; Brand, R.; Kievit, J.; Thomeer, R.T.

    2008-01-01

    OBJECTIVE: To determine whether the faster recovery after early surgery for sciatica compared with prolonged conservative care is attained at reasonable costs. DESIGN: Cost utility analysis alongside a randomised controlled trial. SETTING: Nine Dutch hospitals. PARTICIPANTS: 283 patients with sciati

  17. Genome-wide analysis of trans-splicing in the nematode Pristionchus pacificus unravels conserved gene functions for germline and dauer development in divergent operons.

    Science.gov (United States)

    Sinha, Amit; Langnick, Claudia; Sommer, Ralf J; Dieterich, Christoph

    2014-09-01

    Discovery of trans-splicing in multiple metazoan lineages led to the identification of operon-like gene organization in diverse organisms, including trypanosomes, tunicates, and nematodes, but the functional significance of such operons is not completely understood. To see whether the content or organization of operons serves similar roles across species, we experimentally defined operons in the nematode model Pristionchus pacificus. We performed affinity capture experiments on mRNA pools to specifically enrich for transcripts that are trans-spliced to either the SL1- or SL2-spliced leader, using spliced leader-specific probes. We obtained distinct trans-splicing patterns from the analysis of three mRNA pools (total mRNA, SL1 and SL2 fraction) by RNA-seq. This information was combined with a genome-wide analysis of gene orientation and spacing. We could confirm 2219 operons by RNA-seq data out of 6709 candidate operons, which were predicted by sequence information alone. Our gene order comparison of the Caenorhabditis elegans and P. pacificus genomes shows major changes in operon organization in the two species. Notably, only 128 out of 1288 operons in C. elegans are conserved in P. pacificus. However, analysis of gene-expression profiles identified conserved functions such as an enrichment of germline-expressed genes and higher expression levels of operonic genes during recovery from dauer arrest in both species. These results provide support for the model that a necessity for increased transcriptional efficiency in the context of certain developmental processes could be a selective constraint for operon evolution in metazoans. Our method is generally applicable to other metazoans to see if similar functional constraints regulate gene organization into operons.

  18. [Record of Decision for 1985 Kenai National Wildlife Refuge: Comprehensive Conservation Plan, Environmental Impact Statement and Wilderness Review: Supporting Documents For Wilderness Proposal Package

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document contains the record of decision for the Kenai National Wildlife Refuge Comprehensive Conservation Plan/Environmental Impact Statement/ Wilderness...

  19. Sino-European Cooperation in Flood Analysis Support System

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    @@ Flaced with imminent floods, what should decision-makers do first: evacuate the population,reinforce or intentionally break dikes? A support decision system developed by an international team of researchers will help them to make appropriate decisions to limit flood damage.

  20. Analysis of I Marine Expeditionary Force Support Team Reset Operations

    Science.gov (United States)

    2013-06-01

    ACKNOWLEDGMENTS The author accepted the common saying by John Donne “no man is an island,” but after this experience these wise words are now fully...of this thesis, thank you for your patience and unyielding support; a very SPECIAL THANK YOU to: Jerry Copley and Kevin DeLuca, Donn VanDeren, 1st

  1. A Framework to Support Requirements Analysis in Engineering Design

    OpenAIRE

    Brace, William; Cheutet, Vincent

    2012-01-01

    International audience; Complex system development activities such as requirements analysis to requirements specification, implementation and verification are well defined in the software engineering domain. Interests in using a model driven engineering have increased in this domain. System level requirements analysis and model driven engineering may result in a significant improvement in engineering design. This paper presents a Checklist Oriented Requirement Analysis (CORA) framework to dev...

  2. Comparative genome analysis reveals a conserved family of actin-like proteins in apicomplexan parasites

    Directory of Open Access Journals (Sweden)

    Sibley L David

    2005-12-01

    Full Text Available Abstract Background The phylum Apicomplexa is an early-branching eukaryotic lineage that contains a number of important human and animal pathogens. Their complex life cycles and unique cytoskeletal features distinguish them from other model eukaryotes. Apicomplexans rely on actin-based motility for cell invasion, yet the regulation of this system remains largely unknown. Consequently, we focused our efforts on identifying actin-related proteins in the recently completed genomes of Toxoplasma gondii, Plasmodium spp., Cryptosporidium spp., and Theileria spp. Results Comparative genomic and phylogenetic studies of apicomplexan genomes reveals that most contain only a single conventional actin and yet they each have 8–10 additional actin-related proteins. Among these are a highly conserved Arp1 protein (likely part of a conserved dynactin complex, and Arp4 and Arp6 homologues (subunits of the chromatin-remodeling machinery. In contrast, apicomplexans lack canonical Arp2 or Arp3 proteins, suggesting they lost the Arp2/3 actin polymerization complex on their evolutionary path towards intracellular parasitism. Seven of these actin-like proteins (ALPs are novel to apicomplexans. They show no phylogenetic associations to the known Arp groups and likely serve functions specific to this important group of intracellular parasites. Conclusion The large diversity of actin-like proteins in apicomplexans suggests that the actin protein family has diverged to fulfill various roles in the unique biology of intracellular parasites. Conserved Arps likely participate in vesicular transport and gene expression, while apicomplexan-specific ALPs may control unique biological traits such as actin-based gliding motility.

  3. The miRNAome of globe artichoke: conserved and novel micro RNAs and target analysis

    Directory of Open Access Journals (Sweden)

    De Paola Domenico

    2012-01-01

    Full Text Available Abstract Background Plant microRNAs (miRNAs are involved in post-transcriptional regulatory mechanisms of several processes, including the response to biotic and abiotic stress, often contributing to the adaptive response of the plant to adverse conditions. In addition to conserved miRNAs, found in a wide range of plant species a number of novel species-specific miRNAs, displaying lower levels of expression can be found. Due to low abundance, non conserved miRNAs are difficult to identify and isolate using conventional approaches. Conversely, deep-sequencing of small RNA (sRNA libraries can detect even poorly expressed miRNAs. No miRNAs from globe artichoke have been described to date. We analyzed the miRNAome from artichoke by deep sequencing four sRNA libraries obtained from NaCl stressed and control leaves and roots. Results Conserved and novel miRNAs were discovered using accepted criteria. The expression level of selected miRNAs was monitored by quantitative real-time PCR. Targets were predicted and validated for their cleavage site. A total of 122 artichoke miRNAs were identified, 98 (25 families of which were conserved with other plant species, and 24 were novel. Some miRNAs were differentially expressed according to tissue or condition, magnitude of variation after salt stress being more pronounced in roots. Target function was predicted by comparison to Arabidopsis proteins; the 43 targets (23 for novel miRNAs identified included transcription factors and other genes, most of which involved in the response to various stresses. An unusual cleaved transcript was detected for miR393 target, transport inhibitor response 1. Conclusions The miRNAome from artichoke, including novel miRNAs, was unveiled, providing useful information on the expression in different organs and conditions. New target genes were identified. We suggest that the generation of secondary short-interfering RNAs from miR393 target can be a general rule in the plant

  4. Prediction, conservation analysis, and structural characterization of mammalian mucin-type O-glycosylation sites

    DEFF Research Database (Denmark)

    Julenius, Karin; Mølgaard, Anne; Gupta, Ramneek;

    2004-01-01

    than a nonglycosylated one. The Protein Data Bank was analyzed for structural information, and 12 glycosylated structures were obtained. All positive sites were found in coil or turn regions. A method for predicting the location for mucin-type glycosylation sites was trained using a neural network...... could be predicted from averaged properties together with the fact that glycosylation sites are not precisely conserved indicates that mucin-type glycosylation in most cases is a bulk property and not a very site-specific one. NetOGlyc 3.1 is made available at www.cbs.dtu.dk/services/netoglyc....

  5. Prediction, conservation analysis, and structural characterization of mammalian mucin-type O-glycosylation sites

    DEFF Research Database (Denmark)

    Julenius, Karin; Mølgaard, Anne; Gupta, Ramneek;

    2005-01-01

    than a nonglycosylated one. The Protein Data Bank was analyzed for structural information, and 12 glycosylated structures were obtained. All positive sites were found in coil or turn regions. A method for predicting the location for mucin-type glycosylation sites was trained using a neural network...... could be predicted from averaged properties together with the fact that glycosylation sites are not precisely conserved indicates that mucin-type glycosylation in most cases is a bulk property and not a very site-specific one. NetOGlyc 3.1 is made available at www.cbs.dtu.dk/services/netoglyc....

  6. Navy Additive Manufacturing: Policy Analysis for Future DLA Material Support

    Science.gov (United States)

    2014-12-01

    NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA MBA PROFESSIONAL REPORT NAVY ADDITIVE MANUFACTURING : POLICY ANALYSIS FOR FUTURE...REPORT TYPE AND DATES COVERED MBA Professional Report 4. TITLE AND SUBTITLE NAVY ADDITIVE MANUFACTURING : POLICY ANALYSIS FOR FUTURE DLA MATERIAL...of technology adoption theories and their application to Additive Manufacturing (AM) in the Navy and wider Department of Defense. It examines AM

  7. IT-Supported Modeling, Analysis and Design of Supply Chains

    Science.gov (United States)

    Nienhaus, Jörg; Alard, Robert; Sennheiser, Andreas

    A common language is a prerequisite for analyzing and optimizing supply chains. Based on experiences with three case studies, this paper identifies the aspects of a supply chain that have to be mapped to take informed decisions on its operations. Current, integrated modeling approaches for supply chains, like the SCOR and the GSCM model, will be analyzed and an advanced approach will be defined. The resulting approach takes advantage of IT-support.

  8. Analysis of steel silo structures on discrete supports

    OpenAIRE

    Li,Hongyu

    1994-01-01

    The objective of this thesis is to broaden current knowledge of the strength and buckling/collapse of shells, with special reference to steel silo structures on discrete supports, and thus to provide design guidance of practical value for future silo design and construction and to develop new research aspects for further investigation. A linear elastic solution of the cylindrical shell bending equations is presented for local loadings, with special attention to local longitudinal distri...

  9. Analysis of government policies to support sustainable domestic defense industries

    OpenAIRE

    2015-01-01

    Approved for public release; distribution is unlimited Armed forces all over the world need military equipment to support their security missions. Having a domestic defense industry is one approach that countries use to supply their armed forces’ requirements. The successful development of a domestic defense industry depends on many factors, but perhaps the most significant variable is the government. Because governments are both buyers and suppliers of national security, government polici...

  10. Social Behavior in Medulloblastoma: Functional Analysis of Tumor-Supporting

    Science.gov (United States)

    2013-07-01

    experts in signal transduction and the medical community. With the support of UVa leadership and the dedication of lab members, the lab has started full...on Shh pathway hyperactivation, originate from granule neuron precursors (GNPs). It is puzzling that although GNPs are unipotent toward the granule...differences in signaling context between transforming and non- responsive cell types could provide critical insights for devising highly effective

  11. Proteomic Analysis of Pathogenic Fungi Reveals Highly Expressed Conserved Cell Wall Proteins

    Directory of Open Access Journals (Sweden)

    Jackson Champer

    2016-01-01

    Full Text Available We are presenting a quantitative proteomics tally of the most commonly expressed conserved fungal proteins of the cytosol, the cell wall, and the secretome. It was our goal to identify fungi-typical proteins that do not share significant homology with human proteins. Such fungal proteins are of interest to the development of vaccines or drug targets. Protein samples were derived from 13 fungal species, cultured in rich or in minimal media; these included clinical isolates of Aspergillus, Candida, Mucor, Cryptococcus, and Coccidioides species. Proteomes were analyzed by quantitative MSE (Mass Spectrometry—Elevated Collision Energy. Several thousand proteins were identified and quantified in total across all fractions and culture conditions. The 42 most abundant proteins identified in fungal cell walls or supernatants shared no to very little homology with human proteins. In contrast, all but five of the 50 most abundant cytosolic proteins had human homologs with sequence identity averaging 59%. Proteomic comparisons of the secreted or surface localized fungal proteins highlighted conserved homologs of the Aspergillus fumigatus proteins 1,3-β-glucanosyltransferases (Bgt1, Gel1-4, Crf1, Ecm33, EglC, and others. The fact that Crf1 and Gel1 were previously shown to be promising vaccine candidates, underlines the value of the proteomics data presented here.

  12. Inference of transcriptional networks in Arabidopsis through conserved noncoding sequence analysis.

    Science.gov (United States)

    Van de Velde, Jan; Heyndrickx, Ken S; Vandepoele, Klaas

    2014-07-01

    Transcriptional regulation plays an important role in establishing gene expression profiles during development or in response to (a)biotic stimuli. Transcription factor binding sites (TFBSs) are the functional elements that determine transcriptional activity, and the identification of individual TFBS in genome sequences is a major goal to inferring regulatory networks. We have developed a phylogenetic footprinting approach for the identification of conserved noncoding sequences (CNSs) across 12 dicot plants. Whereas both alignment and non-alignment-based techniques were applied to identify functional motifs in a multispecies context, our method accounts for incomplete motif conservation as well as high sequence divergence between related species. We identified 69,361 footprints associated with 17,895 genes. Through the integration of known TFBS obtained from the literature and experimental studies, we used the CNSs to compile a gene regulatory network in Arabidopsis thaliana containing 40,758 interactions, of which two-thirds act through binding events located in DNase I hypersensitive sites. This network shows significant enrichment toward in vivo targets of known regulators, and its overall quality was confirmed using five different biological validation metrics. Finally, through the integration of detailed expression and function information, we demonstrate how static CNSs can be converted into condition-dependent regulatory networks, offering opportunities for regulatory gene annotation.

  13. Analysis of radiation pneumonitis outside the radiation field in breast conserving therapy for early breast cancer

    Energy Technology Data Exchange (ETDEWEB)

    Ogo, Etsuyo; Fujimoto, Kiminori; Hayabuchi, Naofumi [Kurume Univ., Fukuoka (Japan). School of Medicine] (and others)

    2002-02-01

    In a retrospective study of radiation-induced pulmonary changes for patients with breast conserving therapy for early breast cancer, we sent questionnaires to the main hospitals in Japan. In this study, we analyzed pulmonary changes after tangential whole-breast irradiation. The purpose of this study was to determine the incidence and risk factors for radiation pneumonitis outside the radiation field. The questionnaires included patients data, therapy data, and lung injury information between August 1999 and May 2000. On the first questionnaires, answer letters were received from 107 institutions out of 158 (67.7%). On the second questionnaires, response rate (hospitals which had radiation pneumonitis outside the radiation field) was 21.7% (23/106). We could find no risk factors of this type of pneumonitis. We suggested that lung irradiation might trigger this type of pneumonitis which is clinically similar to BOOP (bronchiolitis obliterans organizing pneumonia). It developed in 1.5-2.1% among the patients with breast conserving surgery and tangential whole-breast irradiation. And it is likely appeared within 6 months after radiotherapy. (author)

  14. NGO Partnerships in Using Ecotourism for Conservation: Systematic Review and Meta-Analysis.

    Science.gov (United States)

    Romero-Brito, Tania P; Buckley, Ralf C; Byrne, Jason

    2016-01-01

    We analyse 214 cases worldwide where non-governmental organisations (NGOs) use ecotourism for conservation. Other stakeholders in these initiatives include local communities, the private sector, and government agencies. Stakeholder relationships determine NGO roles and project management structures and governance. We classified cases into 10 structural categories based on the initiating stakeholder and the NGO role, and used these categories to analyze geographic patterns and success factors. Most of the 214 cases are community-based (~170; 79%); most are in developing countries (190; 89%); and most are in protected areas (196; 91%). Frequencies of structural categories differ between continents. More cases in Latin America and Asia are initiated by NGOs and local communities, and more in Africa by the private sector. Case-study authors used a range of economic, socio-cultural and environmental criteria to judge whether projects were successful. At global scale, we found no significant association between project success and the involvement of private tourism entrepreneurs. Projects involving either local or international NGOs had higher success rates than those that involved both simultaneously. Future research could adopt political ecology approaches to examine: the factors that lead NGOs to adopt ecotourism enterprises; their internal decision-making processes and strategies; their interactions with the stakeholders involved; and their conservation goals and outcomes.

  15. Structural and functional analysis of hypothetical and conserved proteins of Clostridium tetani.

    Science.gov (United States)

    Enany, Shymaa

    2014-01-01

    The progress in biological technologies has led to rapid accumulation of microbial genomic sequences with a vast number of uncharacterized genes. Proteins encoded by these genes are usually uncharacterized, hypothetical, and/or conserved. In Clostridium tetani (C. tetani), these proteins constitute up to 50% of the expressed proteins. In this regard, understanding the functions and the structures of these proteins is crucially important, particularly in C. tetani, which is a medically important pathogen. Here, we used a variety of bioinformatics tools and databases to analyze 10 hypothetical and conserved proteins in C. tetani. We were able to provide a detailed overview of the functional contributions of some of these proteins in several cellular functions, including (1) evolving antibiotic resistance, (2) interaction with enzymes pathways, and (3) involvement in drug transportation. Among these candidates, we postulated the involvement of one of these hypothetical proteins in the pathogenic activity of tetanus. The structural and functional prediction of these proteins should serve in uncovering and better understanding the function of C. tetani cells to ultimately discover new possible drug targets.

  16. Buckling Analysis of Supporting Skirt of Security Injection Tank

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    The purpose of the calculating is to make a structural buckling analysis according to the code rules and the design requirements in order to judge whether the security injection tank have the ability to resist the buckling failure or not

  17. A Quantitative Analysis of the Extrinsic and Intrinsic Turnover Factors of Relational Database Support Professionals

    Science.gov (United States)

    Takusi, Gabriel Samuto

    2010-01-01

    This quantitative analysis explored the intrinsic and extrinsic turnover factors of relational database support specialists. Two hundred and nine relational database support specialists were surveyed for this research. The research was conducted based on Hackman and Oldham's (1980) Job Diagnostic Survey. Regression analysis and a univariate ANOVA…

  18. Analysis for interaction of supports and surrounding rock of gateways in Iongwall minging

    Institute of Scientific and Technical Information of China (English)

    伍永平

    2001-01-01

    Gateway supporting in long-wall mining has been a problem that restricts the mine production and safety, the paper sets up an interaction model between support and surrounding rock ( rock mass structure) and probes the elementary t.heory about ground pressure behaviors of gateway. Based on the analysis of supporting theories, some new viewpoints about gateways supporting and ground pressure controlling are put forward.

  19. Importance of vegetation analysis in the conservation management of the endangered butterfly Aloeides dentatis dentatis (Swierstra (Lepidoptera, Lycaenidae

    Directory of Open Access Journals (Sweden)

    M.S. Deutschlander

    1999-02-01

    Full Text Available The study of the vegetation of the Ruimsig Entomological Reserve, Gauteng, South Africa revealed four plant communities one of which could be subdivided into two subcommunities and variants. The extensive climax stage of the vegetation represented by the Themeda triandra - Trachypogon spicatus grassland was found to be too dense and tall to support the butterfly Aloeides dentatis dentatis and the host ant Lepisiota capensis (Mayr. A degraded phase caused by succession in an area where pipes have been laid was found to be ideal habitat for both ant and butterfly. This vegetation also contained adequate numbers of the food plant Hermannia depressa. A serai community with tall- growing Hyparrhenia hirta was also found to be an unsuitable habitat for the butterfly. The identification of the preferred ideal habitat for the host ant and butterfly resulted in the compilation of a conservation management strategy that ensured the survival of the rare and endangered butterfly.

  20. The Evaluation of Water Conservation for Municipal and Industrial Water Supply: Illustrative Examples. Water Conservation and Supply Information Transfer and Analysis Program. Revision.

    Science.gov (United States)

    1981-02-01

    percent is for toilets and none is for showers. (Although there are showers in hotels /motels, this consumption is small when compared to the total...commercial consumption. Since hotels /motels pay the water bill for guests, it is in their best interest to install water conserving showers and many have...appointment on the enclosed form and return it to us. Upon our arrival in Tucson we will call to confirm the appointment. We will be staying at the Marriot

  1. Particle-number conserving analysis of the high-spin structure of $^{159}$Ho

    CERN Document Server

    Zhang, Zhen-Hua

    2016-01-01

    The high-spin rotational bands in odd-$Z$ nuclei $^{159}$Ho ($Z=67$) are investigated using the cranked shell model with the pairing correlations treated by a particle-number conserving method, in which the blocking effects are taken into account exactly. The experimental moments of inertia and alignments and their variations with the rotational frequency $\\hbar\\omega$ are reproduced very well by the calculations. The splitting between the signature partners of the yrast band $7/2^-[523]$ is discussed and the splitting of the excited band $7/2^+[404]$ above $\\hbar\\omega \\sim 0.30$~MeV is predicted due to the level crossing with $1/2^+[411]$. The calculated $B(E2)$ transition probabilities are also suggested for future experiments.

  2. Residential energy use and conservation actions: Analysis of disaggregate household data

    Science.gov (United States)

    Hirst, E.; Goeltz, R.; Carney, J.

    1981-03-01

    The Energy Information Administration recently published data collected from the National Interim Energy Consumption Survey (NIECS). NIECS includes detailed information on 4081 individual households; demographic characteristics, energy related features of the structure, heating equipment and appliances, conservation actions taken by the household, and fuel consumption and cost for the April 1978 to March 1979 one year period. The NIECS data on household energy consumption - total energy use, electricity use, and use of the primary space heating fuel, are summarized and analyzed. The regression equations constructed explain roughly half the variation in energy use among households. These equations contain ten or fewer independent variables, the most important of which are fuel price, year house was built, floor area, and heating degree days. Regression equations were developed that estimate the energy saving achieved by each household based on their recent retrofit actions.

  3. [Energy Conservation and Emissions Reduction Benefits Analysis for Battery Electric Buses Based on Travel Services].

    Science.gov (United States)

    Lin, Xiao-dan; Tian, Liang; Lü, Bin; Yang, Jian-xin

    2015-09-01

    Battery Electric Bus (BEB) has become one of prior options of urban buses for its "zero emission" during the driving stage. However, the environmental performance of electric buses is affected by multi-factors from the point of whole life cycle. In practice, carrying capacity of BEB and power generation structures can both implement evident effects on the energy consumption and pollutants emission of BEB. Therefore, take the above factors into consideration, in this article, Life Cycle Assessment is employed to evaluate the energy conservation and emissions reduction benefits of BEB. Results indicate that, travel service is more reasonable as the functional unit, rather than mileage, since the carrying capacity of BEB is 15% lower than the diesel buses. Moreover, compared with diesel buses, the energy conservation and emissions reduction benefits of battery electric buses are all different due to different regional power structures. Specifically, the energy benefits are 7. 84%, 11. 91%, 26. 90%, 11. 15%, 19. 55% and 20. 31% respectively in Huabei, Huadong, Huazhong, Dongbei, Xibei and Nanfang power structure. From the point of comprehensive emissions reduction benefits, there is no benefit in Huabei power structure, as it depends heavily on coal. But in other areas, the comprehensive emissions reduction benefits of BEB are separately 3. 46%, 26. 81%, 1. 17%, 13. 74% and 17. 48% in Huadong, Huazhong, Dongbei, Xibei and Nanfang. Therefore, it suggests that, enlargement of carrying capacity should be taken as the most prior technology innovation direction for BEB, and the grids power structure should be taken into consideration when the development of BEB is in planning.

  4. Application of agriculture-developed demographic analysis for the conservation of the Hawaiian alpine wekiu bug.

    Science.gov (United States)

    Eiben, Jesse; Rubinoff, Daniel

    2014-08-01

    Insects that should be considered for conservation attention are often overlooked because of a lack of data. The detailed information necessary to assess population growth, decline, and maximum range is particularly difficult to acquire for rare and cryptic species. Many of these difficulties can be overcome with the use of life table analyses and heat energy accumulation models common in agriculture. The wekiu bug (Nysius wekiuicola), endemic to the summit of one volcanic mountain in Hawaii, is a rare insect living in an environmentally sensitive alpine stone desert, where field-based population assessments would be inefficient or potentially detrimental to natural and cultural resources. We conducted laboratory experiments with the insects by manipulating rearing temperatures of laboratory colonies and made detailed observations of habitat conditions to develop life tables representing population growth parameters and environmental models for wekiu bug phenology and demographic change. Wekiu bugs developed at temperatures only found in its environment on sunny days and required the thermal buffer found on cinder cones for growth and population increase. Wekiu bugs required approximately 3.5 months to complete one generation. The bug developed optimally from 26 to 30 °C, temperatures that are much higher than the air temperature attains in its elevational range. The developmental temperature range of the species confirmed a physiological reason why the wekiu bug is only found on cinder cones. This physiology information can help guide population monitoring and inform habitat restoration and conservation. The wekiu bug was a candidate for listing under the U.S. Endangered Species Act, and the developmental parameters we quantified were used to determine the species would not be listed as endangered or threatened. The use of developmental threshold experiments, life table analyses, and degree day modeling can directly inform otherwise unobservable habitat needs and

  5. Analysis of trends in water-quality data for water conservation area 3A, the Everglades, Florida

    Science.gov (United States)

    Mattraw, H.C.; Scheidt, D.J.; Federico, A.C.

    1987-01-01

    Rainfall and water quality data bases from the South Florida Water Management District were used to evaluate water quality trends at 10 locations near or in Water Conservation Area 3A in The Everglades. The Seasonal Kendall test was applied to specific conductance, orthophosphate-phosphorus, nitrate-nitrogen, total Kjeldahl nitrogen, and total nitrogen regression residuals for the period 1978-82. Residuals of orthophosphate and nitrate quadratic models, based on antecedent 7-day rainfall at inflow gate S-11B, were the only two constituent-structure pairs that showed apparent significant (p Elimination of regression models with distinct residual patterns and data outlines resulted in 17 statistically significant station water quality combinations for trend analysis. No water quality trends were observed. The 1979 Memorandum of Agreement outlining the water quality monitoring program between the Everglades National Park and the U.S. Army Corps of Engineers stressed collection four times a year at three stations, and extensive coverage of water quality properties. Trend analysis and other rigorous statistical evaluation programs are better suited to data monitoring programs that include more frequent sampling and that are organized in a water quality data management system. Pronounced areal differences in water quality suggest that a water quality monitoring system for Shark River Slough in Everglades National Park include collection locations near the source of inflow to Water Conservation Area 3A. (Author 's abstract)

  6. Genomic analysis of the Pacific oyster (Crassostrea gigas) reveals possible conservation of vertebrate sex determination in a mollusc.

    Science.gov (United States)

    Zhang, Na; Xu, Fei; Guo, Ximing

    2014-09-11

    Despite the prevalence of sex in animal kingdom, we have only limited understanding of how sex is determined and evolved in many taxa. The mollusc Pacific oyster Crassostrea gigas exhibits complex modes of sexual reproduction that consists of protandric dioecy, sex change, and occasional hermaphroditism. This complex system is controlled by both environmental and genetic factors through unknown molecular mechanisms. In this study, we investigated genes related to sex-determining pathways in C. gigas through transcriptome sequencing and analysis of female and male gonads. Our analysis identified or confirmed novel homologs in the oyster of key sex-determining genes (SoxH or Sry-like and FoxL2) that were thought to be vertebrate-specific. Their expression profile in C. gigas is consistent with conserved roles in sex determination, under a proposed model where a novel testis-determining CgSoxH may serve as a primary regulator, directly or indirectly interacting with a testis-promoting CgDsx and an ovary-promoting CgFoxL2. Our findings plus previous results suggest that key vertebrate sex-determining genes such as Sry and FoxL2 may not be inventions of vertebrates. The presence of such genes in a mollusc with expression profiles consistent with expected roles in sex determination suggest that sex determination may be deeply conserved in animals, despite rapid evolution of the regulatory pathways that in C. gigas may involve both genetic and environmental factors.

  7. Characterizing Species at Risk II: Using Bayesian Belief Networks as Decision Support Tools to Determine Species Conservation Categories Under the Northwest Forest Plan

    Directory of Open Access Journals (Sweden)

    Mark H. Huff

    2006-12-01

    Full Text Available We developed a set of decision-aiding models as Bayesian belief networks (BBNs that represented a complex set of evaluation guidelines used to determine the appropriate conservation of hundreds of potentially rare species on federally-administered lands in the Pacific Northwest United States. The models were used in a structured assessment and paneling procedure as part of an adaptive management process that evaluated new scientific information under the Northwest Forest Plan. The models were not prescriptive but helped resource managers and specialists to evaluate complicated and at times conflicting conservation guidelines and to reduce bias and uncertainty in evaluating the scientific data. We concluded that applying the BBN modeling framework to complex and equivocal evaluation guidelines provided a set of clear, intuitive decision-aiding tools that greatly aided the species evaluation and conservation process.

  8. Computing support for advanced medical data analysis and imaging

    CERN Document Server

    Wiślicki, W; Białas, P; Czerwiński, E; Kapłon, Ł; Kochanowski, A; Korcyl, G; Kowal, J; Kowalski, P; Kozik, T; Krzemień, W; Molenda, M; Moskal, P; Niedźwiecki, S; Pałka, M; Pawlik, M; Raczyński, L; Rudy, Z; Salabura, P; Sharma, N G; Silarski, M; Słomski, A; Smyrski, J; Strzelecki, A; Wieczorek, A; Zieliński, M; Zoń, N

    2014-01-01

    We discuss computing issues for data analysis and image reconstruction of PET-TOF medical scanner or other medical scanning devices producing large volumes of data. Service architecture based on the grid and cloud concepts for distributed processing is proposed and critically discussed.

  9. An Analysis of Current Operational Contract Support Planning Doctrine

    Science.gov (United States)

    2015-09-01

    analysis of doctrine and planning assets . The activities include interviews with various contracting and logistics professionals. F. RESEARCH...doctrine typically neglects the tangible and intangible capabilities that using OCS in missions brings to the operational and combatant commander. While... measuring the maturity of a process in practice within an organization through the issuing of surveys and measuring the responses. The model used

  10. APPLICATION OF THE QUALITY NORMS TO THE MONITORING AND THE PREVENTIVE CONSERVATION ANALYSIS OF THE CULTURAL HERITAGE

    Directory of Open Access Journals (Sweden)

    Massimo Andretta

    2015-06-01

    Full Text Available In recent years, the study of the indoor microclimate has assumed increasing importance, especially for the problems associated with the conservation of the cultural heritage housed in museums, galleries and libraries. In this paper, we describe the most important national standards relative to the procedures for the measurements and the analysis of the environmental conditions regarding the preservation of the works of art. These methods are related to the measurement techniques, which have to be applied for monitoring and analyzing the microclimatic conditions of museums, galleries and archives; these norms report, also, the threshold reference values for optimal climatic conditions. Furthermore, we present some considerations on the importance and on the foundations of the proposed scientific/methodological approaches. Finally, we have done a reasoned analysis on some reference values reported by the international regulations with some considerations on the possible chemical/physical mechanisms of degradation of the valuable objects.

  11. Conservative management.

    Science.gov (United States)

    Kruis, W; Leifeld, L; Pfützer, R

    2012-01-01

    Treatment of diverticulitis comprises at least two options: conservative or surgical management. There is a recent trend to limit surgical treatment of acute diverticulitis and to favor conservative management. This review addresses general aspects of conservative patient care with special focus on the treatment of patients with a first attack of diverticulitis. The presentation does not include a discussion of specific drugs which is given in other sections of this issue.

  12. Analysis of ecological context for identifying vegetation and animal conservation planning foci: An example from the arid South-western USA

    Science.gov (United States)

    Hamazaki, T.; Thompson, B.C.; Locke, B.A.; Boykin, K.G.

    2003-01-01

    In developing conservation strategies, it is important to maximize effects of conservation within a specified land tract and to maximize conservation effects on surrounding area (ecological context). The authors proposed two criteria to select biotic entities for conservation foci: (1) the relative occurrence of fauna or flora in a tract is greater than that of an ecological context region; and (2) occurrence of the fauna or flora is relatively limited in the ecological context region. Using extensive spatial data on vegetation and wildlife habitat distribution, the authors identified strategic vegetation and fauna conservation foci for the 400 000 ha Fort Bliss military reservation in New Mexico and Texas relative to a 164 km radius ecological context region intersecting seven ecological zones and the predicted habitat distribution of 616 animal species. The authors set two specific criteria: (1) predicted area of a species' occurrence is 5% (Fort Bliss is 4.2% of the region). These criteria selected one vegetation class and 40 animal species. Further, these vegetation and animal foci were primarily located in two areas of Fort Bliss. Sensitivity analyses with other analytical radii corroborated the context radius used. Conservation of the two areas and associated taxa will maximize the contribution of Fort Bliss's conservation efforts in its ecological proximity. This relatively simple but information-rich process represents economical and defensible preliminary contextual analysis for detailed conservation planning.

  13. Representational Similarity Analysis Reveals Heterogeneous Networks Supporting Speech Motor Control

    DEFF Research Database (Denmark)

    Zheng, Zane; Cusack, Rhodri; Johnsrude, Ingrid;

    The everyday act of speaking involves the complex processes of speech motor control. One important feature of such control is regulation of articulation when auditory concomitants of speech do not correspond to the intended motor gesture. While theoretical accounts of speech monitoring posit...... is supported by a complex neural network that is involved in linguistic, motoric and sensory processing. With the aid of novel real-time acoustic analyses and representational similarity analyses of fMRI signals, our data show functionally differentiated networks underlying auditory feedback control of speech....... multiple functional components required for detection of errors in speech planning (e.g., Levelt, 1983), neuroimaging studies generally indicate either single brain regions sensitive to speech production errors, or small, discrete networks. Here we demonstrate that the complex system controlling speech...

  14. SENSITIVITY ANALYSIS FOR ROLLING PROCESS BASED ON SUPPORT VECTOR MACHINE

    Institute of Scientific and Technical Information of China (English)

    Huang Yanwei; Wu Tihua; Zhao Jingyi; Wang Yiqun

    2005-01-01

    A method for the calculation of the sensitivity factors of the rolling process has been obtained by differentiating the roll force model based on support vector machine. It can eliminate the algebraic loop of the analytical model of the rolling process. The simulations in the first stand of five stand cold tandem rolling mill indicate that the calculation for sensitivities by this proposed method can obtain a good accuracy, and an appropriate adjustment on the control variables determined directly by the sensitivity has an excellent compensation accuracy. Moreover, the roll gap has larger effect on the exit thickness than both front tension and back tension, and it is more efficient to select the roll gap as the controlvariable of the thickness control system in the first stand.

  15. Design Support Method Based on Analysis of Shape Impression

    Institute of Scientific and Technical Information of China (English)

    HITOMI Yokoyama; HIDEKI Aoyama

    2011-01-01

    In recent years, aesthetic design is becoming increasingly important in industrial product development due to the growing maturity of product functions. The designer is required to reflect consumer needs in the aesthetic design while giving consideration to the applications and functions of the product. For this reason, effective techniques enabling design creation based on consumer preference and needs are indispensable. The Taguchi method has been effectively used for the robust design of products. In this study, we proposed a design support method applying the Taguchi Method to robust design in respect to the inconsistencies of human kansei(sensitivity), and specifically applied it for quantitatively analyzing the robustness of design solutions created in accordance with the design concept of a digital camera.

  16. Urban life cycle analysis and the conservation of the urban fabric

    DEFF Research Database (Denmark)

    Algreen-Ussing, Gregers; Hassler, U.; Kohler, N.

    2004-01-01

    This position paper has been prepared in the framework of the SUIT project - Sustainable Development of Urban Historical Areas Through an Active Integration within Towns. The SUIT project is supported by the EU Programm "Energy, Environment and Sustainable Development", Key Action 4: The City...

  17. Metro Conservation Corridors

    Data.gov (United States)

    Minnesota Department of Natural Resources — The Metro Conservation Corridors (MeCC) grow out of the natural resource analysis work done by the DNR in the late '90's, documented in the Metro Greenprint...

  18. Directory of Federally Supported Information Analysis Centers, 1979. Fourth Edition.

    Science.gov (United States)

    1979-01-01

    monitoring program for yield. brine disposal in the Gulf of Mexico from leaching of salt domes, under an agreement with the HOLDINGS: Computerized...SPR/Salt Dome Storage-Analysis of Brine Disposal in the Gulf of Mexico (1977); journal ar- HOLDINGS: Computerized data base on the ticles...Electrochemistry, 68 Glaciology, 60 . Electroluminescence, 34 Glass, 34, 65, 103 Electrolysis , 33 Graduate study, 42 Joining, 65 Electrolyte solutions

  19. Preliminary Analysis of Helicopter Options to Support Tunisian Counterterrorism Operations

    Science.gov (United States)

    2016-04-27

    results of the current analysis and in Mouton et al., 2015, is the relative cost -effectiveness between the CH-47D and the Mi-17v5. In the previous...helicopters from Sikorsky to fulfill a number of roles in counterterrorism operations. Rising costs and delays in delivery raised the question of...whether other cost -effective options exist to meet Tunisia’s helicopter requirement. Approach Our team conducted a preliminary assessment of

  20. The use of SWOT analysis to explore and prioritize conservation and development strategies for local cattle breeds.

    Science.gov (United States)

    Martín-Collado, D; Díaz, C; Mäki-Tanila, A; Colinet, F; Duclos, D; Hiemstra, S J; Gandini, G

    2013-06-01

    SWOT (Strengths, Weaknesses, Opportunities and Threats) analysis is a tool widely used to help in decision making in complex systems. It suits to exploring the issues and measures related to the conservation and development of local breeds, as it allows the integration of many driving factors influencing breed dynamics. We developed a quantified SWOT method as a decision-making tool for identification and ranking of conservation and development strategies of local breeds, and applied it to a set of 13 cattle breeds of six European countries. The method has four steps: definition of the system, identification and grouping of the driving factors, quantification of the importance of driving factors and identification and prioritization of the strategies. The factors were determined following a multi-stakeholder approach and grouped with a three-level structure. Animal genetic resources expert groups ranked the factors, and a quantification process was implemented to identify and prioritize strategies. The proposed SWOT methodology allows analyzing the dynamics of local cattle breeds in a structured and systematic way. It is a flexible tool developed to assist different stakeholders in defining the strategies and actions. The quantification process allows the comparison of the driving factors and the prioritization of the strategies for the conservation and development of local cattle breeds. We identified 99 factors across the breeds. Although the situation is very heterogeneous, the future of these breeds may be promising. The most important strengths and weaknesses were related to production systems and farmers. The most important opportunities were found in marketing new products, whereas the most relevant threats were found in selling the current products. The across-breed strategies utility decreased as they gained specificity. Therefore, the strategies at European level should focus on general aspects and be flexible enough to be adapted to the country and breed

  1. Comparative analysis of microsatellite variability in five macaw species (Psittaciformes, Psittacidae: application for conservation

    Directory of Open Access Journals (Sweden)

    Flavia T. Presti

    2011-01-01

    Full Text Available Cross-amplification was tested and variability in microsatellite primers (designed for Neotropical parrots compared, in five macaw species, viz., three endangered blue macaws (Cyanopsitta spixii [extinct in the wild], Anodorhynchus leari [endangered] and Anodorhynchus hyacinthinus [vulnerable], and two unthreatened red macaws (Ara chloropterus and Ara macao. Among the primers tested, 84.6% successfully amplified products in C. spixii, 83.3% in A. leari, 76.4% in A. hyacinthinus, 78.6% in A. chloropterus and 71.4% in A. macao. The mean expected heterozygosity estimated for each species, and based on loci analyzed in all the five, ranged from 0.33 (A. hyacinthinus to 0.85 (A. macao. As expected, the results revealed lower levels of genetic variability in threatened macaw species than in unthreatened. The low combined probability of genetic identity and the moderate to high potential for paternity exclusion, indicate the utility of the microsatellite loci set selected for each macaw species in kinship and population studies, thus constituting an aid in planning in-situ and ex-situ conservation.

  2. Bitemark analysis: Use of polyether in evidence collection, conservation, and comparison

    Directory of Open Access Journals (Sweden)

    Gabriel M Fonseca

    2009-01-01

    Full Text Available Background: While bitemarks are categorical identification evidence, the dynamics of biting, the anatomical location of the bite, and failures in wound records can introduce distorted images and mislead crime investigation. Materials and Methods: In this study, 20 bitemarks were performed on dead pig skin and subsequently photographed, excised, conserved, and analyzed using digital comparison (Adobe Photoshop™ 8.0, following the standard procedures (ABFO; physical comparison was also done using polyether (Impregum™; 3M casts. Study plaster casts of the upper and lower jaws of each subject were taken using type IV yellow densite stone. Polyether was used as impression material to obtain bitemarks, and casts were made from densite stone and polyether. Results: Because of its elasticity, polyether casts can compensate for primary or secondary distortions, so that there is a better degree of match when positioning the subject′s dental cast. Conclusion: Polyether is an alternative impression material and is an excellent option for creating positive casts of the wound for physical dynamic comparison.

  3. Conservative medical therapy of prosthetic joint infections: retrospective analysis of an 8-year experience.

    Science.gov (United States)

    Pavoni, G L; Giannella, M; Falcone, M; Scorzolini, L; Liberatore, M; Carlesimo, B; Serra, P; Venditti, M

    2004-09-01

    Successful treatment of prosthetic joint infections often requires multiple surgical interventions and prolonged antimicrobial therapy. However, in certain situations, a surgical approach may not be in the best interest of the patient. A conservative approach was used to treat 34 patients with prosthetic joint infection between 1995 and 2003. Diagnosis of infection was based on clinical-microbiological evidence, confirmed by (99)Tc-labelled leukocyte scintigraphy, and involved 12 Staphylococcus aureus infections, nine Staphylococcus epidermidis infections, two Enterococcus faecalis infections, two mixed infections (S. aureus plus Pseudomonas aeruginosa; S. epidermidis plus E. faecalis), with the infecting pathogen being unidentified for nine patients. Most infections were treated initially with intravenous or intramuscular teicoplanin +/- ciprofloxacin or rifampicin, followed by oral ciprofloxacin or minocycline plus rifampicin. The mean duration of antimicrobial therapy was 41.2 weeks. Overall, only three patients did not respond to therapy, and infection was controlled in the remaining 31 patients. Among these, no relapse was observed in 17 patients during follow-up for 9-57 months; improvement with early (within 6 months of antibiotic discontinuation) or late relapse was observed in seven and three patients, respectively; two patients improved clinically, but continued to receive antibiotic therapy; and two patients whose condition improved initially were lost after a 6-month follow-up following discontinuation of antibiotics. No patient complained of side effects requiring discontinuation of antibiotic therapy. The study confirmed that suppression of infection, with salvage of the infected device in an acceptably functional state, can be achieved in selected cases.

  4. Analysis of chromosome conservation in Lemur catta studied by chromosome paints and BAC/PAC probes.

    Science.gov (United States)

    Cardone, Maria Francesca; Ventura, Mario; Tempesta, Sergio; Rocchi, Mariano; Archidiacono, Nicoletta

    2002-12-01

    A panel of human chromosome painting probes and bacterial and P1 artificial chromosome (BAC/PAC) clones were used in fluorescence in situ hybridization (FISH) experiments to investigate the chromosome conservation of the ring-tailed lemur (Lemur catta, LCA) with respect to human. Whole chromosome paints specific for human chromosomes 7, 9, 11, 13, 14, 17, 18, 20, 21, and X were found to identify a single chromosome or an uninterrupted chromosomal region in LCA. A large set of partial chromosome paints and BAC/PAC probes were then used to refine the characterization of the rearrangements differentiating the two karyotypes. The results were also used to reconstruct the ancestral Lemuridae karyotype. Lemur catta, indeed, can be used as an outgroup, allowing symplesiomorphic (ancestral) rearrangements to be distinguished from apomorphic (derived) rearrangements in lemurs. Some LCA chromosomes are difficult to distinguish morphologically. The 'anchorage' of most LCA chromosomes to specific probes will contribute to the standardization of the karyotype of this species.

  5. Nature Conservation Policies and Strategies

    Directory of Open Access Journals (Sweden)

    Ildiko IOAN

    2011-08-01

    Full Text Available Humans dependence on nature is beyond doubt one of the most powerfulevidence that supports the thesis of environmental protection. This relation is manifold and it was approached in various frameworks. The paper focuses on the conservation of nature in its narrow sense, meaning natural ecosystems and biodiversity. Although this topic is among the top priorities in environmental policymaking, the progresses recorded to date are not reflecting this position. The analysis aims to highlight the main policies and strategies and the developments for new actions targeting improved effectiveness.

  6. Health organizations providing and seeking social support: a Twitter-based content analysis.

    Science.gov (United States)

    Rui, Jian Raymond; Chen, Yixin; Damiano, Amanda

    2013-09-01

    Providing and seeking social support are important aspects of social exchange. New communication technologies, especially social network sites (SNSs), facilitate the process of support exchange. An increasing number of health organizations are using SNSs. However, how they provide and seek social support via SNSs has yet to garner academic attention. This study examined the types of social support provided and sought by health organizations on Twitter. A content analysis was conducted on 1,500 tweets sent by a random sample of 58 health organizations within 2 months. Findings indicate that providing informational and emotional support, as well as seeking instrumental support, were the main types of social support exchanged by health organizations through Twitter. This study provides a typology for studying social support exchanges by health organizations, and recommends strategies for health organizations regarding the effective use of Twitter.

  7. Use of Grid Tools to Support CMS Distributed Analysis

    CERN Document Server

    Fanfani, A; Anjum, A; Barrass, T; Bonacorsi, D; Bunn, J; Corvo, M; Darmenov, N; De Filippis, N; Donno, F; Donvito, G; Eulisse, G; Fanzago, F; Filine, A; Grandi, C; Hernández, J M; Innocente, V; Jan, A; Lacaprara, S; Legrand, I; Metson, S; Newman, H; Silvestris, L; Steenberg, C; Stockinger, H; Taylor, L; Thomas, M; Tuura, L; Van Lingen, F; Wildish, T

    2004-01-01

    In order to prepare the Physic Technical Design Report, due by end of 2005, the CMS experiment needs to simulate, reconstruct and anlayse about 100 million events, corresponding to more than 200 TB of data. The data will be distributed to several Computing Centres. In order to provide access to the whole data sample to all the world-wide dispersed physicists, CMS is developing a layer of software that uses the grid tools provided by the LCG project to gain access to data and resources and that aims to provide physicists with a user friendly interface for submitting analysis jobs. The GRID tools used are both those already available in the LCG-2 release and those being developed in gain access to data and resources and that aims to provide physicists with a user friendly interface for submitting analysis jobs. The GRID tools used are both those already available in the LCG-2 release and those being developed in the framework of the ARDA project. This work describes the current status and the future development...

  8. Stress Analysis of Single Spacer Grid Support considering Fuel Rod

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, Y. G.; Jung, D. H.; Kim, J. H. [Chungnam National University, Daejeon (Korea, Republic of); Park, J. K.; Jeon, K. L. [Korea Nuclear Fuel, Daejeon (Korea, Republic of)

    2010-10-15

    Pressurized water reactor (PWR) nuclear fuel assembly is mainly composed of a top-end piece, a bottom-end piece, lots of fuel rods, and several spacer grids. Among them, the main function of spacer grid is protecting fuel rods from Fluid Induced Vibration (FIV). The cross section of spacer grid assembled by laser welding in upper and lower point. When the fuel rod inserted in spacer gird, spring and dimple and around of welded area got a stresses. The main hypothesis of this analysis is the boundary area of HAZ and base metal can get a lot of damage than other area by FIV. So, design factors of spacer grid mainly considered to preventing the fatigue failure in HAZ and spring and dimple of spacer grid. From previous researching, the environment in reactor verified. Pressure and temperature of light water observed 15MPa and 320 .deg. C, and vibration of the fuel rod observed within 0 {approx} 50Hz. In this study, mechanical properties of zirconium alloy that extracted from the test and the spacer grid model which used in the PWR were applied in stress analyzing. General-purpose finite element analysis program was used ANSYS Workbench 12.0.1 version. 3-D CAD program CATIA was used to create spacer grid model

  9. The impact of information and other factors on on-farm agrobiodiversity conservation: evidence from a duration analysis of Portuguese fruit growers

    Energy Technology Data Exchange (ETDEWEB)

    Botelho, A.; Dinis, I.; Costa Pinto, L.

    2012-11-01

    In spite of the increasing awareness of the importance of in situ and on-farm conservation of agro biodiversity, there is still limited knowledge about the factors that influence farmers choices in variety adoption. The purpose of this paper is to contribute to a better understanding of the factors that influence farmers adoption of traditional varieties of fruit trees so that better and more effective policy measures aiming at their preservation can be designed. While studies in this area have mainly employed standard probit/logit techniques, in this paper, an econometric technique which addresses simultaneously the issue of sample censoring and the joint determination of the occurrence and timing of adoptions duration analysis was applied. The use of this technique in the analysis of adoption data uncovers a sizably higher effect of information on farmers decisions than that obtained by standard approaches. The results strongly support the idea that good extension services providing reliable and accessible information, as well as technical guidance adapted to local conditions, are fundamental components in determining the adoption of land races. (Author)

  10. ENERGY CONSERVATION AND GRAVITY WAVES IN SOUND-PROOF TREATMENTS OF STELLAR INTERIORS. II. LAGRANGIAN CONSTRAINED ANALYSIS

    Energy Technology Data Exchange (ETDEWEB)

    Vasil, Geoffrey M.; Lecoanet, Daniel [Department of Astronomy and Theoretical Astrophysics Center, University of California Berkeley, Berkeley, CA 94720 (United States); Brown, Benjamin P.; Zweibel, Ellen G. [Department of Astronomy, University of Wisconsin, Madison, WI 53706-1582 (United States); Wood, Toby S., E-mail: vasil@cita.utoronto.ca [Department of Applied Mathematics and Statistics, Baskin School of Engineering, University of California, Santa Cruz, CA (United States)

    2013-08-20

    The speed of sound greatly exceeds typical flow velocities in many stellar and planetary interiors. To follow the slow evolution of subsonic motions, various sound-proof models attempt to remove fast acoustic waves while retaining stratified convection and buoyancy dynamics. In astrophysics, anelastic models typically receive the most attention in the class of sound-filtered stratified models. Generally, anelastic models remain valid in nearly adiabatically stratified regions like stellar convection zones, but may break down in strongly sub-adiabatic, stably stratified layers common in stellar radiative zones. However, studying stellar rotation, circulation, and dynamos requires understanding the complex coupling between convection and radiative zones, and this requires robust equations valid in both regimes. Here we extend the analysis of equation sets begun in Brown et al., which studied anelastic models, to two types of pseudo-incompressible models. This class of models has received attention in atmospheric applications, and more recently in studies of white-dwarf supernova progenitors. We demonstrate that one model conserves energy but the other does not. We use Lagrangian variational methods to extend the energy conserving model to a general equation of state, and dub the resulting equation set the generalized pseudo-incompressible (GPI) model. We show that the GPI equations suitably capture low-frequency phenomena in both convection and radiative zones in stars and other stratified systems, and we provide recommendations for converting low-Mach number codes to this equation set.

  11. The Value of Intraoperative Frozen Section Analysis for Margin Status in Breast Conservation Surgery in a Nontertiary Institution

    Directory of Open Access Journals (Sweden)

    Mona P. Tan

    2014-01-01

    Full Text Available Introduction. Breast conservation treatment (BCT for early-stage breast malignancies requires negative margins and good cosmesis. Reoperations may be needed to achieve negative margins, which can have an adverse impact on outcomes. This study was performed to evaluate the efficacy of intraoperative frozen section analysis (IFSA for margin assessment to reduce excision rates. Methods. All patients treated at the authors’ private healthcare facility between 2009 and 2011 for breast cancer were included in the study. Those for whom BCT was intended underwent wide excision with IFSA. Six margins of the excised tissue, and the sentinel lymph node (SLN, where appropriate, were submitted for IFSA. Patient demographics, tumour characteristics, number of operations performed, and outcomes were analysed. Results. Of the 161 patients analysed, 138 (85.7% had successful breast conservation. Four patients required a reoperation for incomplete surgical extirpation. One had a false negative SLN assessment on IFSA, and was returned to the operating room for an axillary dissection. Three patients required reoperations for inadvertently missed multicentric disease. None had false negative margin evaluation with IFSA necessitating reexcision. Conclusion. The use of IFSA allows low rates of reoperation with BCT. Further research is needed to establish consistency in low reexcision rates for cost-effectiveness and optimum resource allocation.

  12. Comparative Analysis of Genome and Epigenome in Closely Related Medaka Species Identifies Conserved Sequence Preferences for DNA Hypomethylated Domains.

    Science.gov (United States)

    Uno, Ayako; Nakamura, Ryohei; Tsukahara, Tatsuya; Qu, Wei; Sugano, Sumio; Suzuki, Yutaka; Morishita, Shinichi; Takeda, Hiroyuki

    2016-08-01

    The genomes of vertebrates are globally methylated, but a small portion of genomic regions are known to be hypomethylated. Although hypomethylated domains (HMDs) have been implicated in transcriptional regulation in various ways, how a HMD is determined in a particular genomic region remains elusive. To search for DNA motifs essential for the formation of HMDs, we performed the genome-wide comparative analysis of genome and DNA methylation patterns of the two medaka inbred lines, Hd-rRII1 and HNI-II, which are derived from northern and southern subpopulations of Japan and exhibit high levels of genetic variations (SNP, ∼ 3%). We successfully mapped > 70% of HMDs in both genomes and found that the majority of those mapped HMDs are conserved between the two lines (common HMDs). Unexpectedly, the average genetic variations are similar in the common HMD and other genome regions. However, we identified short well-conserved motifs that are specifically enriched in HMDs, suggesting that they may play roles in the establishment of HMDs in the medaka genome.

  13. Identification of a Conserved 8 aa Insert in the PIP5K Protein in the Saccharomycetaceae family of Fungi and the Molecular Dynamics Simulations and Structural Analysis to investigate its Potential Functional Role.

    Science.gov (United States)

    Khadka, Bijendra; Gupta, Radhey S

    2017-04-13

    Homologs of the phosphatidylinositol-4-phosphate-5-kinase (PIP5K), which controls a multitude of essential cellular functions, contain a 8 aa insert in a conserved region that is specific for the Saccharomycetaceae family of fungi. Using structures of human PIP4K proteins as templates, structural models were generated of the Saccharomyces cerevisiae and human PIP5K proteins. In the modeled S. cerevisiae PIP5K, the 8 aa insert forms a surface exposed loop, present on the same face of the protein as the activation loop of the kinase domain. Electrostatic potential analysis indicates that the residues from 8 aa conserved loop form a highly-positively charged surface patch, which through electrostatic interaction with the anionic portions of phospholipid head groups, is expected to play a role in the membrane interaction of the yeast PIP5K. To unravel this prediction, molecular dynamics (MD) simulations were carried out to examine the binding interaction of PIP5K, either containing or lacking the conserved signature insert (CSI), with two different membrane lipid bilayers. The results from MD studies provide insights concerning the mechanistic of interaction of PIP5K with lipid bilayer, and support the contention that the identified 8 aa conserved insert in fungal PIP5K plays an important role in the binding of this protein with membrane surface. This article is protected by copyright. All rights reserved.

  14. [Screening of Bacillus thuringiensis strains containing vip3A genes and analysis of gene conservation].

    Science.gov (United States)

    Chen, Jian-Wu; Tang, Li-Xia; Song, Shao-Yun; Yuan, Mei-Jin; Pang, Yi

    2003-09-01

    Vip3A, a novel insecticidal protein, is secreted by Bacillus thuringiensis (Bt) during vegetative growth. Vip3A protein possesses insecticidal activity against a wild spectrum of lepidopteran insect larvae. Since the first cloning of vip3A gene from Bt, many other vip3A genes have been isolated. To investigate vip3A genes contribution to Bt and reflect the revolution relationships, the strains containing vip3A genes were screened and gene similarity was analyzed. 114 wild-type Bacillus thuringiensis (Bt) strains isolated from different regions and 41 standard Bt strains from the Institute of Pasteur were screened for the vip3A genes using PCR amplification. 39 strains including B. thuringiensis subsp. kurstaki (Btk) HD-1 were found to contain the vip3A genes. Because acrystallerous strain Cry- B derived from Btk HD-1 was proved not to contain vip3A gene, it suppose that the vip3A gene may be located at the plasmids. Vip3A proteins expressed in these strains were detected with polyclonal antibody by Western blot and 4 strains among them were shown not to express the Vip3A proteins. The vip3A genes amplified from wild-type Bacillus thuringiensis strains S101 and 611 with different levels of activity against lepidopteran insect larvae were cloned into pGEM-T Easy vector. Alignment of these 2 putative Vip3A proteins with 6 others (Vip3A (a), Vip3A(b), Vip3A-S, Vip3A-S184, Vip83 and Vip3V) in the GenBank data base and 2 reported Vip3A proteins (Vip14 and Vip15) showed that vip3A genes are highly conservative. The plasmids pOTP-S101 and pOTP-611 were constructed by in- serting 2 vip3A genes (vip3A-S101 and vip3A-611) into the expression vector pQE30 respectively and were transformed into E. coli M15. E. coli M15 cells harboring the pOTP plasmids were induced with 1 mmol/L IPTG to express 89 kDa protein. Experiments showed that the level of soluble proteins of Vip3A-S101 in E. coli M15[pOTP-S101] and Vip3A-611 in E. coli M15 [pOTP-611] were about 48% and 35% respectively

  15. Mutational Analysis of the Absolutely Conserved B8Gly: Consequence on Foldability and Activity of Insulin

    Institute of Scientific and Technical Information of China (English)

    Zhan-Yun GUO; Zhou ZHANG; Xiao-Yuan JIA; Yue-Hua TANG; You-Min FENG

    2005-01-01

    B8Gly is absolutely conserved in insulins during evolution. Moreover, its corresponding position is always occupied by a Gly residue in other members of insulin superfamily. Previous work showed that Ala replacement of B8Gly significantly decreased both the activity and the foldability of insulin. However,the effects of substitution are complicated, and different replacements sometimes cause significantly different results. To analyze the effects of B8 replacement by different amino acids, three new insulin/single-chain insulin mutants with B8Gly replaced by Ser, Thr or Leu were prepared by protein engineering, and both their foldability and activity were analyzed. In general, replacement of B8Gly by other amino acids causes significant detriment to the foldability of single-chain insulin: the conformations of the three B8 mutants are essentially different from that of wild-type molecules as revealed by circular dichroism; their disulfide stabilities in redox buffer are significantly decreased; their in vitro refolding efficiencies are decreased approximately two folds; the structural stabilities of the mutants with Ser or Thr substitution are decreased significantly,while Leu substitution has little effect as measured by equilibrium guanidine denaturation. As far as biological activity is concerned, Ser replacement of B8Gly has only a moderate effect: its insulin receptor-binding activity is 23% of native insulin. But Thr or Leu replacement produces significant detriment: the receptorbinding potencies of the two mutants are less than 0.2% of native insulin. The present results suggest that Gly is likely the only applicable natural amino acid for the B8 position of insulin where both foldability and activity are concerned.

  16. Planning nature in urbanized countries. An analysis of monetary and non-monetary impacts of conservation policy scenarios in the Netherlands.

    Science.gov (United States)

    Sijtsma, Frans J; van der Bilt, Willem G M; van Hinsberg, Arjen; de Knegt, Bart; van der Heide, Martijn; Leneman, Hans; Verburg, René

    2017-03-01

    Planning and conserving nature areas are challenging tasks in urbanized and intensively used countries like the Netherlands. This paper supports decision making and public policy debate about these tasks in both an empirical and a methodological way. Empirically, we explore policy alternatives by determining the potential consequences of different nature policy scenarios in the Netherlands. Methodologically, we employ a mixed monetary and non-monetary evaluation method known as multi-criteria cost-benefit analysis (MCCBA). We evaluate four new future directions of Dutch nature policy that address four dominant stakeholder demands: biodiversity conservation, the provision of ecosystem services, recreational potential as well as economic gains. To balance compact presentation of evaluation outcomes on the one hand and information richness of results on the other, we distinguish between two impact indicator sets: three "headline" and ten "elaborate" indicators. Using these indicators we discuss the quantitative assessment of the four nature policy scenarios by comparing them to two other scenarios, reflecting the 2010 stand-still baseline situation (2010) as well as a reference policy (Trend). In total, we evaluate six scenarios; four present new directions and two reflect existing or recently (2010) halted practices. Our findings first of all show that even in an urbanized country like the Netherlands, with its intensive competition among land use functions, serious gains in national and international biodiversity are possible. Second, we find that it is doubtful whether stimulating the provision of regulating ecosystem services in a country which applies intensive and profitable agricultural techniques is beneficial. Other countries or areas that are less suitable for intensive agricultural practices may be more logical for this. Finally we demonstrate that increasing urban recreational green space - a common challenge for many urban areas - can only be achieved at

  17. Canister storage building (CSB) safety analysis report phase 3: Safety analysis documentation supporting CSB construction

    Energy Technology Data Exchange (ETDEWEB)

    Garvin, L.J.

    1997-04-28

    The Canister Storage Building (CSB) will be constructed in the 200 East Area of the U.S. Department of Energy (DOE) Hanford Site. The CSB will be used to stage and store spent nuclear fuel (SNF) removed from the Hanford Site K Basins. The objective of this chapter is to describe the characteristics of the site on which the CSB will be located. This description will support the hazard analysis and accident analyses in Chapter 3.0. The purpose of this report is to provide an evaluation of the CSB design criteria, the design's compliance with the applicable criteria, and the basis for authorization to proceed with construction of the CSB.

  18. Analysis for interaction of supports and surrounding rock of gateways in longwall minging

    Institute of Scientific and Technical Information of China (English)

    WU Yong-ping

    2001-01-01

    Gateway supporting in long-wall mining has been a problem that restri cts the mine production and safety, the paper sets up an interaction model betwe en support and surrounding rock (rock mass structure) and probes the elementary theory about ground pressure behaviors of gateway. Based on the analysis of supp orting theories, some new viewpoints about gateways supporting and ground pressu re controlling are put forward.

  19. SEPAC data analysis in support of the environmental interaction program

    Science.gov (United States)

    Lin, Chin S.

    1991-01-01

    Data analyses of the Space Experiments with Particle Accelerators (SEPAC) data and computer modeling were conducted to investigate spacecraft environmental effects associated with injection of electron beams, plasma clouds, and neutral gas clouds from the Shuttle orbiter. The data analysis indicates that Extremely Low Frequency oscillations from 150 to 200 Hz were seen in the Langmuir probe current when the beam was fired in a continuous mode. The strongest oscillations occurred when the ambient pressure was augmented by neutral gas releases from the SEPAC plasma accelerator magnetoplasma-dynamic (MPD) arcjet. To understand the dependence of spacecraft charging potential on beam density and other plasma parameters, a two-dimensional electrostatic particle code was used to simulate the injection of electron beams from an infinite conductor into a plasma. The simulations show that the conductor charging potential depends critically on the reflection coefficient of the conductor surface, which is defined as the percentage of incident particles reflected by the conductor. The ionization effects on spacecraft charging were examined by including interactions of electrons with neutral gas. The simulations show that the conductor charging potential decreases with increasing neutral background density due to the production of secondary electrons near the conductor surface. The simulations also indicate that the beam radius is generally proportional to the beam electron gyroradius when the conductor is charged to a large potential. It appears that the charge buildup at the beam stagnation point causes the beam radial expansion. A survey of the simulation results suggests that the ratio of the beam radius to the beam electron gyroradius increases with the square root of beam density and decreases inversely with beam injection velocity. These results are useful for explaining the spacecraft charging phenomena observed during SEPAC experiments from Spacelab 1.

  20. Buffering by gene duplicates: an analysis of molecular correlates and evolutionary conservation

    Directory of Open Access Journals (Sweden)

    Vogel Christine

    2008-12-01

    Full Text Available Abstract Background One mechanism to account for robustness against gene knockouts or knockdowns is through buffering by gene duplicates, but the extent and general correlates of this process in organisms is still a matter of debate. To reveal general trends of this process, we provide a comprehensive comparison of gene essentiality, duplication and buffering by duplicates across seven bacteria (Mycoplasma genitalium, Bacillus subtilis, Helicobacter pylori, Haemophilus influenzae, Mycobacterium tuberculosis, Pseudomonas aeruginosa, Escherichia coli, and four eukaryotes (Saccharomyces cerevisiae (yeast, Caenorhabditis elegans (worm, Drosophila melanogaster (fly, Mus musculus (mouse. Results In nine of the eleven organisms, duplicates significantly increase chances of survival upon gene deletion (P-value ≤ 0.05, but only by up to 13%. Given that duplicates make up to 80% of eukaryotic genomes, the small contribution is surprising and points to dominant roles of other buffering processes, such as alternative metabolic pathways. The buffering capacity of duplicates appears to be independent of the degree of gene essentiality and tends to be higher for genes with high expression levels. For example, buffering capacity increases to 23% amongst highly expressed genes in E. coli. Sequence similarity and the number of duplicates per gene are weak predictors of the duplicate's buffering capacity. In a case study we show that buffering gene duplicates in yeast and worm are somewhat more similar in their functions than non-buffering duplicates and have increased transcriptional and translational activity. Conclusion In sum, the extent of gene essentiality and buffering by duplicates is not conserved across organisms and does not correlate with the organisms' apparent complexity. This heterogeneity goes beyond what would be expected from differences in experimental approaches alone. Buffering by duplicates contributes to robustness in several organisms

  1. Comparative analysis of function and interaction of transcription factors in nematodes: Extensive conservation of orthology coupled to rapid sequence evolution

    Directory of Open Access Journals (Sweden)

    Singh Rama S

    2008-08-01

    Full Text Available Abstract Background Much of the morphological diversity in eukaryotes results from differential regulation of gene expression in which transcription factors (TFs play a central role. The nematode Caenorhabditis elegans is an established model organism for the study of the roles of TFs in controlling the spatiotemporal pattern of gene expression. Using the fully sequenced genomes of three Caenorhabditid nematode species as well as genome information from additional more distantly related organisms (fruit fly, mouse, and human we sought to identify orthologous TFs and characterized their patterns of evolution. Results We identified 988 TF genes in C. elegans, and inferred corresponding sets in C. briggsae and C. remanei, containing 995 and 1093 TF genes, respectively. Analysis of the three gene sets revealed 652 3-way reciprocal 'best hit' orthologs (nematode TF set, approximately half of which are zinc finger (ZF-C2H2 and ZF-C4/NHR types and HOX family members. Examination of the TF genes in C. elegans and C. briggsae identified the presence of significant tandem clustering on chromosome V, the majority of which belong to ZF-C4/NHR family. We also found evidence for lineage-specific duplications and rapid evolution of many of the TF genes in the two species. A search of the TFs conserved among nematodes in Drosophila melanogaster, Mus musculus and Homo sapiens revealed 150 reciprocal orthologs, many of which are associated with important biological processes and human diseases. Finally, a comparison of the sequence, gene interactions and function indicates that nematode TFs conserved across phyla exhibit significantly more interactions and are enriched in genes with annotated mutant phenotypes compared to those that lack orthologs in other species. Conclusion Our study represents the first comprehensive genome-wide analysis of TFs across three nematode species and other organisms. The findings indicate substantial conservation of transcription

  2. Paradigms for parasite conservation.

    Science.gov (United States)

    Dougherty, Eric R; Carlson, Colin J; Bueno, Veronica M; Burgio, Kevin R; Cizauskas, Carrie A; Clements, Christopher F; Seidel, Dana P; Harris, Nyeema C

    2016-08-01

    Parasitic species, which depend directly on host species for their survival, represent a major regulatory force in ecosystems and a significant component of Earth's biodiversity. Yet the negative impacts of parasites observed at the host level have motivated a conservation paradigm of eradication, moving us farther from attainment of taxonomically unbiased conservation goals. Despite a growing body of literature highlighting the importance of parasite-inclusive conservation, most parasite species remain understudied, underfunded, and underappreciated. We argue the protection of parasitic biodiversity requires a paradigm shift in the perception and valuation of their role as consumer species, similar to that of apex predators in the mid-20th century. Beyond recognizing parasites as vital trophic regulators, existing tools available to conservation practitioners should explicitly account for the unique threats facing dependent species. We built upon concepts from epidemiology and economics (e.g., host-density threshold and cost-benefit analysis) to devise novel metrics of margin of error and minimum investment for parasite conservation. We define margin of error as the risk of accidental host extinction from misestimating equilibrium population sizes and predicted oscillations, while minimum investment represents the cost associated with conserving the additional hosts required to maintain viable parasite populations. This framework will aid in the identification of readily conserved parasites that present minimal health risks. To establish parasite conservation, we propose an extension of population viability analysis for host-parasite assemblages to assess extinction risk. In the direst cases, ex situ breeding programs for parasites should be evaluated to maximize success without undermining host protection. Though parasitic species pose a considerable conservation challenge, adaptations to conservation tools will help protect parasite biodiversity in the face of

  3. A Meta-Analysis of Effectiveness Studies on Computer Technology-Supported Language Learning

    Science.gov (United States)

    Grgurovic, Maja; Chapelle, Carol A.; Shelley, Mack C.

    2013-01-01

    With the aim of summarizing years of research comparing pedagogies for second/foreign language teaching supported with computer technology and pedagogy not-supported by computer technology, a meta-analysis was conducted of empirical research investigating language outcomes. Thirty-seven studies yielding 52 effect sizes were included, following a…

  4. Structural Analysis of Cuban Typical Model of Telecommunication Self-Supporting Towers under Seismic Load

    Directory of Open Access Journals (Sweden)

    Patricia Martín Rodríguez

    2012-07-01

    Full Text Available Self-supporting lattice towers are slender structures with low damping and high flexibility. They are sensitive to dynamic loads such as wind and earthquake. In the West of Cuba, structures should be analyzed under extreme winds and seismic effects, which raised their frequency during 2010 year. Self-supporting towers do not have the same dynamic behavior as buildings under seismic loads. Their specific structure features are not developed at design seismic codes, for that reason it is necessary to study methods of seismic analysis for self-supporting towers. The methods selected in this research are Modal Analysis Method proposed by Cuban Seismic Code (NC-46:1999 and modal superposition lineal dynamic analysis named Time History. It was selected for the study two self-supporting towers designed in Cuba, Versalles Model (3-legged and Najasa Model (4-legged. Comparative analysis between both methods is realized with extreme values of internal forces at element towers.

  5. Reshaping conservation

    DEFF Research Database (Denmark)

    Funder, Mikkel; Danielsen, Finn; Ngaga, Yonika

    2013-01-01

    members strengthen the monitoring practices to their advantage, and to some extent move them beyond the reach of government agencies and conservation and development practitioners. This has led to outcomes that are of greater social and strategic value to communities than the original 'planned' benefits......, although the monitoring scheme has also to some extent become dominated by local 'conservation elites' who negotiate the terrain between the state and other community members. Our findings suggest that we need to move beyond simplistic assumptions of community strategies and incentives in participatory...... conservation and allow for more adaptive and politically explicit governance spaces in protected area management....

  6. The biological control as a strategy to support nontraditional agricultural exports in Peru: An empirical analysis

    Directory of Open Access Journals (Sweden)

    Franklin Duarte Cueva

    2012-12-01

    Full Text Available The study is oriented to explore the general characteristics of agriculture, the biological control as a pest control mechanism and agro export industry. In this context, we try to promote the use of biological control as a strategy to support nontraditional exports related to products such as asparagus and fresh avocados grown in the La Libertad Department (Peru, through an agronomic and management approach. Biological control is the basis of integrated pest management (IPM and contributes to the conservation of agricultural ecosystems allowing to export companies reduce costs, fulfill international phytosanitary measures and supports the preservation of the environment and health. Thus, the Peruvian agro export companies could build a sustainable competitive advantage and seek a positioning as socially responsible firms. We analyze variables such as crop statistics, comparative costs between biological control and chemical control, main destination markets for asparagus and fresh avocados, international standards, among others.

  7. Fermilab Central Computing Facility: Energy conservation report and mechanical systems design optimization and cost analysis study

    Energy Technology Data Exchange (ETDEWEB)

    Krstulovich, S.F.

    1986-11-12

    This report is developed as part of the Fermilab Central Computing Facility Project Title II Design Documentation Update under the provisions of DOE Document 6430.1, Chapter XIII-21, Section 14, paragraph a. As such, it concentrates primarily on HVAC mechanical systems design optimization and cost analysis and should be considered as a supplement to the Title I Design Report date March 1986 wherein energy related issues are discussed pertaining to building envelope and orientation as well as electrical systems design.

  8. Conservation Tillage of Grain Sorghum and Soybeans:A Stochastic Dominance Analysis

    OpenAIRE

    Mikesell, Chris L.; Williams, Jeffery R.; Long, James H.

    1987-01-01

    Three tillage systems: conventional tillage, ridge tillage and notillage are evaluated using stochastic dominance with respect to a function analysis. Each tillage system is evaluated for three cropping patterns: continuous grain sorghum, continuous soybeans, and soybeans after grain sorghum. Conventional tillage continuous grain sorghum would be preferred by risk averse managers, although small changes in production costs and yield differences could lead to indifference between a no-tillage ...

  9. Radical Rebel or Conservative Apologist: An Analysis of the Divided Mind of Jack Kerouac

    OpenAIRE

    2006-01-01

    This thesis is an analysis of Jack Kerouac s novels On the Road, The Subterraneans, and The Dharma Bums. The angle is Kerouac s ambiguity and his supposed influence on the countercultural movements of the sixties. Themes discussed are among others conformism, spirituality and religion, racial attitudes and sexual behaviours in Kerouac s novels, juxtaposed to the general attitudes of white middle-class society of his time.

  10. Wildlife Conservation

    OpenAIRE

    Clive L. Spash; Aldred, Jonathan

    1998-01-01

    In this paper we consider how conservation has arisen as a key aspect of the reaction to human-initiated degradation and disappearance of ecosystems, wild lands. and wildlife. Concern over species extinction is given an historical perspective which shows the way in which pressure on wild and natural aspects of global ecology have changed in recent centuries. The role of conservation in the struggle to protect the environment is then analysed using underlying ethical arguments behind the econo...

  11. Retrospective analysis of energy use and conservation trends: 1972-1982. Appendix

    Energy Technology Data Exchange (ETDEWEB)

    Adams, R.C.; Belzer, D.B.; Fang, J.M.; Imhoff, K.L.; Lax, D.H.; Moe, R.J.; Roop, J.M.; Wusterbarth, A.R.

    1985-06-01

    This appendix contains the detailed documentation corresponding to the end-use sectoral analyses presented in the main report. The data and methods used to calculate alternative scenarios for estimating energy savings in four economic sectors are provided in this volume. Appendix A contains the detailed documentation for the residential sector analysis. The methodology used to prepare estimates of building energy savings in the commercial sector is provided in Appendix B. Finally, Appendices C and D discuss the data and explain the analytical techniques used to derive estimates of energy savings in the industrial and transportation sectors, respectively. 9 refs., 14 figs., 86 tabs.

  12. Community strategy for mangrove forest conservation: Conquista Campesina Conservation Easement

    OpenAIRE

    2012-01-01

    The drafting of a community plan for mangrove forest conservation in the communal land of Conquista Campesina (Tapachula, Chiapas, Mexico) is part of a more ambitious project aimed at establishing a protected wetlands corridor in the coastal region of the state of Chiapas. The purpose is to guarantee the conservation, protection and restoration of priority wetlands, placing special emphasis on vulnerable ecosystems. With the technical support of Pronatura Sur A. C. and after signing a conserv...

  13. Beyond conservation agriculture

    NARCIS (Netherlands)

    Giller, K.E.; Andersson, J.A.; Corbeels, Marc; Kirkegaard, John; Mortensen, David; Erenstein, Olaf; Vanlauwe, Bernard

    2015-01-01

    Global support for Conservation Agriculture (CA) as a pathway to Sustainable Intensification is strong. CA revolves around three principles: no-till (or minimal soil disturbance), soil cover, and crop rotation. The benefits arising from the ease of crop management, energy/cost/time savings, and s

  14. Comprehensive analysis of long non-coding RNAs highlights their spatio-temporal expression patterns and evolutional conservation in Sus scrofa

    Science.gov (United States)

    Tang, Zhonglin; Wu, Yang; Yang, Yalan; Yang, Yu-Cheng T.; Wang, Zishuai; Yuan, Jiapei; Yang, Yang; Hua, Chaoju; Fan, Xinhao; Niu, Guanglin; Zhang, Yubo; Lu, Zhi John; Li, Kui

    2017-01-01

    Despite modest sequence conservation and rapid evolution, long non-coding RNAs (lncRNAs) appear to be conserved in expression pattern and function. However, analysis of lncRNAs across tissues and developmental stages remains largely uncharacterized in mammals. Here, we systematically investigated the lncRNAs of the Guizhou miniature pig (Sus scrofa), which was widely used as biomedical model. We performed RNA sequencing across 9 organs and 3 developmental skeletal muscle, and developed a filtering pipeline to identify 10,813 lncRNAs (9,075 novel). Conservation patterns analysis revealed that 57% of pig lncRNAs showed homology to humans and mice based on genome alignment. 5,455 lncRNAs exhibited typical hallmarks of regulatory molecules, such as high spatio-temporal specificity. Notably, conserved lncRNAs exhibited higher tissue specificity than pig-specific lncRNAs and were significantly enriched in testis and ovary. Weighted co-expression network analysis revealed a set of conserved lncRNAs that are likely involved in postnatal muscle development. Based on the high degree of similarity in the structure, organization, and dynamic expression of pig lncRNAs compared with human and mouse lncRNAs, we propose that these lncRNAs play an important role in organ physiology and development in mammals. Our results provide a resource for studying animal evolution, morphological complexity, breeding, and biomedical research. PMID:28233874

  15. Comprehensive analysis of long non-coding RNAs highlights their spatio-temporal expression patterns and evolutional conservation in Sus scrofa.

    Science.gov (United States)

    Tang, Zhonglin; Wu, Yang; Yang, Yalan; Yang, Yu-Cheng T; Wang, Zishuai; Yuan, Jiapei; Yang, Yang; Hua, Chaoju; Fan, Xinhao; Niu, Guanglin; Zhang, Yubo; Lu, Zhi John; Li, Kui

    2017-02-24

    Despite modest sequence conservation and rapid evolution, long non-coding RNAs (lncRNAs) appear to be conserved in expression pattern and function. However, analysis of lncRNAs across tissues and developmental stages remains largely uncharacterized in mammals. Here, we systematically investigated the lncRNAs of the Guizhou miniature pig (Sus scrofa), which was widely used as biomedical model. We performed RNA sequencing across 9 organs and 3 developmental skeletal muscle, and developed a filtering pipeline to identify 10,813 lncRNAs (9,075 novel). Conservation patterns analysis revealed that 57% of pig lncRNAs showed homology to humans and mice based on genome alignment. 5,455 lncRNAs exhibited typical hallmarks of regulatory molecules, such as high spatio-temporal specificity. Notably, conserved lncRNAs exhibited higher tissue specificity than pig-specific lncRNAs and were significantly enriched in testis and ovary. Weighted co-expression network analysis revealed a set of conserved lncRNAs that are likely involved in postnatal muscle development. Based on the high degree of similarity in the structure, organization, and dynamic expression of pig lncRNAs compared with human and mouse lncRNAs, we propose that these lncRNAs play an important role in organ physiology and development in mammals. Our results provide a resource for studying animal evolution, morphological complexity, breeding, and biomedical research.

  16. Conserved Structural Motifs at the C-Terminus of Baculovirus Protein IE0 are Important for its Functions in Transactivation and Supporting hr5-mediated DNA Replication

    Directory of Open Access Journals (Sweden)

    Neta Luria

    2012-05-01

    Full Text Available IE0 and IE1 are transactivator proteins of the most studied baculovirus, the Autographa californica multiple nucleopolyhedrovirus (AcMNPV. IE0 is a 72.6 kDa protein identical to IE1 with the exception of its 54 N-terminal amino acid residues. To gain some insight about important structural motifs of IE0, we expressed the protein and C‑terminal mutants of it under the control of the Drosophila heat shock promoter and studied the transactivation and replication functions of the transiently expressed proteins. IE0 was able to promote replication of a plasmid bearing the hr5 origin of replication of AcMNPV in transient transfections with a battery of eight plasmids expressing the AcMNPV genes dnapol, helicase, lef-1, lef-2, lef-3, p35, ie-2 and lef-7. IE0 transactivated expression of the baculovirus 39K promoter. Both functions of replication and transactivation were lost after introduction of selected mutations at the basic domain II and helix-loop-helix conserved structural motifs in the C-terminus of the protein. These IE0 mutants were unable to translocate to the cell nucleus. Our results point out the important role of some structural conserved motifs to the proper functioning of IE0.

  17. A genome-wide identification analysis of small regulatory RNAs in Mycobacterium tuberculosis by RNA-Seq and conservation analysis.

    Directory of Open Access Journals (Sweden)

    Danilo Pellin

    Full Text Available We propose a new method for smallRNAs (sRNAs identification. First we build an effective target genome (ETG by means of a strand-specific procedure. Then we propose a new bioinformatic pipeline based mainly on the combination of two types of information: the first provides an expression map based on RNA-seq data (Reads Map and the second applies principles of comparative genomics leading to a Conservation Map. By superimposing these two maps, a robust method for the search of sRNAs is obtained. We apply this methodology to investigate sRNAs in Mycobacterium tuberculosis H37Rv. This bioinformatic procedure leads to a total list of 1948 candidate sRNAs. The size of the candidate list is strictly related to the aim of the study and to the technology used during the verification process. We provide performance measures of the algorithm in identifying annotated sRNAs reported in three recent published studies.

  18. Comparative Analysis of Forest Conservation and Sustainable Forest Management in China and Germany

    Institute of Scientific and Technical Information of China (English)

    Ying; ZHANG; Qingfeng; QIN; Jieyu; FAN; Ke; CHEN

    2013-01-01

    Forestry development in Germany and China does not seem to be comparable due to differences in nature,politics,economy,society,culture and demographic situation,but the comparative study on these still has great important theoretical and practical significance.Taking into account the significant differences between the two countries,a comparative analysis was carried out through following aspects from(1)forestry policies,strategies and programs,(2)legal regulatory,administrative and socio-economic framework conditions,(3)tools and provisions and other aspects of bilateral forest protection and sustainable forest management.Researches on forest protection and sustainable forest management framework were carried out by combination of forestry development and historical review discussion in order to learn from the German experiences to promote the development of China’s forestry.

  19. An Experimental Analysis of Water and Soil Conservation Effected by Micro-landscape Structure

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    [Objective] This comparative experiment was to explore the soil loss con- trol effects under cultivation combination of different soil and vegetation types, and to provide scientific basis for the upcoming pilot project of ecological recovery. [Method] Both the rudiment of water locomotion functioned by micro-landscape structures and different spatial combinations of various landscape constituents are considered, thus, the combination of multi-soil type, crop species and site conditions is designed in three different experimental sites. [Result] Soil loss estimates in experiments in South Wello significantly depended on various soil type, slope, vegetation and type of con- servation structure; grass cover tremendously reduces soil loss; legume cultivation performed better than cereal cultivation in soil loss control. [Conclusion] By conduct- ing the data analysis of the experiment, a scientific reference is proposed to the agri- culture planting and protective mode for the alleviation of water and soil loss in Amhara Region, Ethiopia.

  20. Comparative transcriptome analysis within the Lolium/Festuca species complex reveals high sequence conservation

    DEFF Research Database (Denmark)

    Czaban, Adrian; Sharma, Sapna; Byrne, Stephen;

    2015-01-01

    -Festuca complex show very diverse phenotypes, including for many agronomically important traits. Analysis of sequenced transcriptomes of these non-model species may shed light on the molecular mechanisms underlying this phenotypic diversity. Results We have generated de novo transcriptome assemblies for four...... species from the Lolium-Festuca complex, ranging from 52,166 to 72,133 transcripts per assembly. We have also predicted a set of proteins and validated it with a high-confidence protein database from three closely related species (H. vulgare, B. distachyon and O. sativa). We have obtained gene family...... phenotypical differences within the complex (such as VRN2). The orthologous genes between the species have a very high %id (91,61%) and the majority of gene families were shared for all of them. It is likely that the knowledge of the genomes will be largely transferable between species within the complex....

  1. CONSERVATIVE ISLAM TURN OR POPULAR ISLAM? an Analysis of the Film Ayat-ayat Cinta

    Directory of Open Access Journals (Sweden)

    Lukman Hakim

    2010-02-01

    Full Text Available This paper offers a film and cultural studies analysis of the Indonesian religious film Ayat-ayat Cinta. It examines the way in which the film represents Islam in the context of the globalisation of the media industry, the wider cultural transformation and religious context in Indonesia. This paper argues that the film Ayat-ayat Cinta represents “popular Islam”, which resulted from the interaction between the santri religious variants and the film industry, capitalism, market forces and popular culture in Indonesia. Santri religious variants in this film are rooted in traditionalist, fundamentalist, modernist, and liberal Islam in Indonesia, and those Islamic groups which have undergone a process of conformity with capitalism and popular culture. As a result, the representation of Islam in this film is pluralist, tolerant, and fashionable. Keywords: Ayat-ayat Cinta, popular Islam, santri, traditionalist, fundamentalist, modernist, cultural studies.

  2. An Analysis of the Invariance and Conservation Laws of Some Classes of Nonlinear Ostrovsky Equations and Related Systems

    Institute of Scientific and Technical Information of China (English)

    K. Fakhar; A. H. Kara

    2011-01-01

    A large class of partial differential equations in the modelling of ocean waves are due to Ostrovsky. We determine the invariance properties (through the Lie point symmetry generators) and construct classes of conservation laws for some of the models. In the latter case, the method involves finding the 'multipliers' associated with the conservation laws with a stronger emphasis on the 'higher-order' ones. The relationship between the symmetries and conservation laws is investigated by considering the invariance properties of the multipliers.

  3. Experimental analysis of the steady-state behaviour of beam systems with discontinuous support

    NARCIS (Netherlands)

    Vorst, E.L.B. van de; Campen, D.H. van; Kraker, A. de; Fey, R.H.B.

    1996-01-01

    This paper deals with the experimental analysis of the long-term behaviour of periodically excited linear beams supported by a one-sided spring or an elastic stop. Numerical analysis of the beams showed subharmonic, quasi-periodic and chaotic behaviour. Furthermore, in the beam system with the one-s

  4. A suite of models to support the quantitative assessment of spread in pest risk analysis

    NARCIS (Netherlands)

    Robinet, C.; Kehlenbeck, H.; Werf, van der W.

    2012-01-01

    In the frame of the EU project PRATIQUE (KBBE-2007-212459 Enhancements of pest risk analysis techniques) a suite of models was developed to support the quantitative assessment of spread in pest risk analysis. This dataset contains the model codes (R language) for the four models in the suite. Three

  5. Structural and Biophysical Analysis of BST-2/Tetherin Ectodomains Reveals an Evolutionary Conserved Design to Inhibit Virus Release

    Energy Technology Data Exchange (ETDEWEB)

    Swiecki, M.; Allaire, M.; Scheaffer, S.; Fremont, D.H.; et.al.

    2011-01-28

    BST-2/tetherin is a host antiviral molecule that functions to potently inhibit the release of enveloped viruses from infected cells. In return, viruses have evolved antagonists to this activity. BST-2 traps budding virions by using two separate membrane-anchoring regions that simultaneously incorporate into the host and viral membranes. Here, we detailed the structural and biophysical properties of the full-length BST-2 ectodomain, which spans the two membrane anchors. The 1.6-{angstrom} crystal structure of the complete mouse BST-2 ectodomain reveals an {approx}145-{angstrom} parallel dimer in an extended {alpha}-helix conformation that predominantly forms a coiled coil bridged by three intermolecular disulfides that are required for stability. Sequence analysis in the context of the structure revealed an evolutionarily conserved design that destabilizes the coiled coil, resulting in a labile superstructure, as evidenced by solution x-ray scattering displaying bent conformations spanning 150 and 180 {angstrom} for the mouse and human BST-2 ectodomains, respectively. Additionally, crystal packing analysis revealed possible curvature-sensing tetrameric structures that may aid in proper placement of BST-2 during the genesis of viral progeny. Overall, this extended coiled-coil structure with inherent plasticity is undoubtedly necessary to accommodate the dynamics of viral budding while ensuring separation of the anchors.

  6. Structural and biophysical analysis of BST-2/tetherin ectodomains reveals an evolutionary conserved design to inhibit virus release.

    Science.gov (United States)

    Swiecki, Melissa; Scheaffer, Suzanne M; Allaire, Marc; Fremont, Daved H; Colonna, Marco; Brett, Tom J

    2011-01-28

    BST-2/tetherin is a host antiviral molecule that functions to potently inhibit the release of enveloped viruses from infected cells. In return, viruses have evolved antagonists to this activity. BST-2 traps budding virions by using two separate membrane-anchoring regions that simultaneously incorporate into the host and viral membranes. Here, we detailed the structural and biophysical properties of the full-length BST-2 ectodomain, which spans the two membrane anchors. The 1.6-Å crystal structure of the complete mouse BST-2 ectodomain reveals an ∼145-Å parallel dimer in an extended α-helix conformation that predominantly forms a coiled coil bridged by three intermolecular disulfides that are required for stability. Sequence analysis in the context of the structure revealed an evolutionarily conserved design that destabilizes the coiled coil, resulting in a labile superstructure, as evidenced by solution x-ray scattering displaying bent conformations spanning 150 and 180 Å for the mouse and human BST-2 ectodomains, respectively. Additionally, crystal packing analysis revealed possible curvature-sensing tetrameric structures that may aid in proper placement of BST-2 during the genesis of viral progeny. Overall, this extended coiled-coil structure with inherent plasticity is undoubtedly necessary to accommodate the dynamics of viral budding while ensuring separation of the anchors.

  7. Scenario analysis for biodiversity conservation: a social-ecological system approach in the Australian Alps.

    Science.gov (United States)

    Mitchell, Michael; Lockwood, Michael; Moore, Susan A; Clement, Sarah

    2015-03-01

    Current policy interventions are having limited success in addressing the ongoing decline in global biodiversity. In part, this is attributable to insufficient attention being paid to the social and governance processes that drive decisions and can undermine their implementation. Scenario planning that draws on social-ecological systems (SES) analysis provides a useful means to systematically explore and anticipate future uncertainties regarding the interaction between humans and biodiversity outcomes. However, the effective application of SES models has been limited by the insufficient attention given to governance influences. Understanding the influence governance attributes have on the future trajectory of SES is likely to assist choice of effective interventions, as well as needs and opportunities for governance reform. In a case study in the Australian Alps, we explore the potential of joint SES and scenario analyses to identify how governance influences landscape-scale biodiversity outcomes. Novel aspects of our application of these methods were the specification of the focal system's governance attributes according to requirements for adaptive capacity, and constraining scenarios according to the current governance settings while varying key social and biophysical drivers. This approach allowed us to identify how current governance arrangements influence landscape-scale biodiversity outcomes, and establishes a baseline from which the potential benefits of governance reform can be assessed.

  8. Genomic analysis of six new Geobacillus strains reveals highly conserved carbohydrate degradation architectures and strategies

    Directory of Open Access Journals (Sweden)

    Phillip eBrumm

    2015-05-01

    Full Text Available In this work we report the whole genome sequences of six new Geobacillus xylanolytic strains along with the genomic analysis of their capability to degrade carbohydrates.. The six sequenced Geobacillus strains described here have a range of GC contents from 43.9% to 52.5% and clade with named Geobacillus species throughout the entire genus. We have identified a ~200 kb unique super-cluster in all six strains, containing five to eight distinct carbohydrate degradation clusters in a single genomic region, a feature not seen in other genera. The Geobacillus strains rely on a small number of secreted enzymes located within distinct clusters for carbohydrate utilization, in contrast to most biomass-degrading organisms which contain numerous secreted enzymes located randomly throughout the genomes. All six strains are able to utilize fructose, arabinose, xylose, mannitol, gluconate, xylan, and α-1,6-glucosides. The gene clusters for utilization of these seven substrates have identical organization and the individual proteins have a high percent identity to their homologs. The strains show significant differences in their ability to utilize inositol, sucrose, lactose, α-mannosides, α-1,4-glucosides and arabinan.

  9. Computation and Analysis of High Rocky Slope Safety in a Water Conservancy Project

    Directory of Open Access Journals (Sweden)

    Meng Yang

    2015-01-01

    Full Text Available An integrated method, covering the actual monitoring analysis, practical geological model, and theoretical mathematical simulation model, is systematically proposed and successfully applied. Deformation characteristic of a unique high rocky slope was firstly analyzed from multiple angles and multiple layers by changeable elevations and distances. Arrangements of monitoring points were listed and monitoring equipment was designed to comprise a complete monitoring system. Present larger displacement was concluded for bottom larger displacement caused by water erosion and middle larger displacement formed by seepage. Temporal and spatial displacements rule study of multiple-points linkage effects with water factor proved this conclusion. To better excavate useful message and analyze the deep rule from the practical monitoring data, the slope geological model was conducted and rock mechanic parameters were researched. Finally, a unique three-dimensional finite element model was applied to approach the structure character using numerical simulations. The corresponding strength criterion was used to determine the safety coefficient by selecting a typical section. Subsequently, an integrated three-dimensional finite element model of the slope and dam was developed and more detailed deformation evolution mechanism was revealed. This study is expected to provide a powerful and systematic method to analyze very high, important, and dangerous slopes.

  10. Economic prosperity, biodiversity conservation, and the environmental Kuznets curve

    Energy Technology Data Exchange (ETDEWEB)

    Mills, Julianne H.; Waite, Thomas A. [Department of Evolution, Ecology and Organismal Biology, Ohio State University, 300 Aronoff Laboratory, 318 W. 12th Ave., Columbus, OH, 43210 (United States)

    2009-05-15

    Many conservationists contend that economic growth and biodiversity conservation are incompatible goals. Some economists contest this viewpoint, arguing that wealthier countries have the luxury of investing more heavily in efforts to conserve biodiversity. Under this assumption, we expect a U-shaped relationship between per capita wealth and proportion of species conserved. We test this environmental Kuznets curve (EKC) using estimates of per capita income and deforestation rates (index of biodiversity threat) for 35 tropical countries. A prior analysis [Dietz, S., Adger, W.N., 2003. Economic growth, biodiversity loss and conservation effort. Journal of Environmental Management, 68:23-35] using conventional regression techniques failed to provide any support for the parabolic relationship predicted by the EKC hypothesis. Here, we introduce the use of quantile regression and spatial filtering to reanalyze this data, addressing issues of heteroskedasticity and spatial autocorrelation. We note that preliminary analysis using these methods provides some initial evidence for an EKC. However, a series of panel analyses with country-specific dummy variables eliminated or even reversed much of this support. A closer examination of conservation practices and environmental indicators within the countries, particularly those countries that drove our initial support, suggests that wealth is not a reliable indicator of improved conservation practice. Our findings indicate that an EKC for biodiversity is overly simplistic and further exploration is required to fully understand the mechanisms by which income affects biodiversity. (author)

  11. Simulation of dynamics behaviors for shipping equipment support with system dynamics analysis approach

    Directory of Open Access Journals (Sweden)

    Yang Song

    2015-05-01

    Full Text Available Purpose: The exactly and precisely supply of carrying spare parts has a crucial impact on support and could improve the performance of equipment. Spare parts support is the crux work which will be limited by spare parts allocation and support cost input. Reasonable support strategy can help in making good use of available resources and support the equipment in normal operational status. The purpose of this paper is to propose a dynamics model of spare parts support process based on considering the interaction of multiple factors, and explores the regulation of dynamics behavior in the system. In order to achieve the optimization strategy to improve the effect of support so that will enhance the relevant support parameters of equipment. Design/methodology/approach: Meditate the feedback relationship among some important factors of support that involve support cost, support time and maintenance ability. System dynamics theory is adopted to propose a dynamics model of spare parts support process, on the analysis of multiple factors and casual relationship to find some major ones which have crucial impact on spare parts support. Spare parts support cost and availability was regarded as the control objective, moreover, adjust the control paramours and improve the effect of cannibalization and lateral supply scheduling strategy for spares support. Findings: The factors of spare parts supply, demand and maintenance have relationship of control feedback, and adjust the value of some crucial factors can reduce the support cost and improve the availability value. The main finding is that adopting cannibalization strategy under condition of available materials can relieve the mission and operational availability decline caused by shortage of spare parts. Combining the lateral supply and cannibalization strategy can reduce the inventory of warship carrying spare parts. Practical implications: By controlling the value of key factors regarding aspect of spare

  12. A multidisciplinary conceptualization of conservation opportunity.

    Science.gov (United States)

    Moon, Katie; Adams, Vanessa M; Januchowski-Hartley, Stephanie R; Polyakov, Maksym; Mills, Morena; Biggs, Duan; Knight, Andrew T; Game, Edward T; Raymond, Christopher M

    2014-12-01

    An opportunity represents an advantageous combination of circumstances that allows goals to be achieved. We reviewed the nature of opportunity and how it manifests in different subsystems (e.g., biophysical, social, political, economic) as conceptualized in other bodies of literature, including behavior, adoption, entrepreneur, public policy, and resilience literature. We then developed a multidisciplinary conceptualization of conservation opportunity. We identified 3 types of conservation opportunity: potential, actors remove barriers to problem solving by identifying the capabilities within the system that can be manipulated to create support for conservation action; traction, actors identify windows of opportunity that arise from exogenous shocks, events, or changes that remove barriers to solving problems; and existing, everything is in place for conservation action (i.e., no barriers exist) and an actor takes advantage of the existing circumstances to solve problems. Different leverage points characterize each type of opportunity. Thus, unique stages of opportunity identification or creation and exploitation exist: characterizing the system and defining problems; identifying potential solutions; assessing the feasibility of solutions; identifying or creating opportunities; and taking advantage of opportunities. These stages can be undertaken independently or as part of a situational analysis and typically comprise the first stage, but they can also be conducted iteratively throughout a conservation planning process. Four types of entrepreneur can be identified (business, policy, social, and conservation), each possessing attributes that enable them to identify or create opportunities and take advantage of them. We examined how different types of conservation opportunity manifest in a social-ecological system (the Great Barrier Reef) and how they can be taken advantage of. Our multidisciplinary conceptualization of conservation opportunity strengthens and

  13. Identification and analysis of 21 novel disease-causing amino acid substitutions in the conserved part of ATP7A

    DEFF Research Database (Denmark)

    Moller, L.B.; Bukrinsky, J.T.; Mølgaard, Anne;

    2005-01-01

    ATP7A encodes a copper. translocating ATPase that belongs to the large family of P-type ATPases. Eight conserved regions define the core of the P-type ATPase superfamily. We report here the identification of 21 novel missense mutations in the conserved part of ATP7A that encodes the residues p.V842...

  14. "The man, the administration and the counter-discourse”: An analysis of the sudden turn in Dutch nature conservation policy

    NARCIS (Netherlands)

    Buijs, A.E.; Mattijssen, T.; Arts, B.J.M.

    2014-01-01

    The Netherlands were at the forefront of European nature conservation policy until recently. For years, a stable ‘social contract’ around Dutch nature conservation existed. To the surprise of many, this stability suddenly disappeared and Dutch nature policy has taken a dramatic shift with changing d

  15. Social support and adjustment to caring for elder family members: A multi-study analysis.

    Science.gov (United States)

    Smerglia, Virginia L; Miller, Nancy B; Sotnak, Diane L; Geiss, Carrie A

    2007-03-01

    This multi-study analysis systematically examines research findings on relationships between social support and caregiver adjustment to discover whether informal support helps family caregivers. Caring for older relatives is an ongoing stressful life course event and role. Informal social support is often used as a predictor of caregiver adjustment outcomes. It is widely believed to enhance adjustment. Yet the varied research results do not necessarily support this belief. A computer-generated literature search of social sciences and medical databases produced thirty-five caregiving articles, published in refereed journals, which meet study parameters. A coding form was developed to categorize social support and adjustment variables for cross-tabular analyses. The findings show most relationships (61%) between social support and caregiver adjustment are not positively significant. Of the minority of positively significant relationships, neither perceived (available) nor received support is more important and neither instrumental nor socioemotional support is more likely to aid adjustment. Researchers and health care professionals need to explore the negative impact of social support and attributes of caregiver-care recipient relationships.

  16. Metabolic flux ratio analysis and multi-objective optimization revealed a globally conserved and coordinated metabolic response of E. coli to paraquat-induced oxidative stress.

    Science.gov (United States)

    Shen, Tie; Rui, Bin; Zhou, Hong; Zhang, Ximing; Yi, Yin; Wen, Han; Zheng, Haoran; Wu, Jihui; Shi, Yunyu

    2013-01-27

    The ability of a microorganism to adapt to changes in the environment, such as in nutrient or oxygen availability, is essential for its competitive fitness and survival. The cellular objective and the strategy of the metabolic response to an extreme environment are therefore of tremendous interest and, thus, have been increasingly explored. However, the cellular objective of the complex regulatory structure of the metabolic changes has not yet been fully elucidated and more details regarding the quantitative behaviour of the metabolic flux redistribution are required to understand the systems-wide biological significance of this response. In this study, the intracellular metabolic flux ratios involved in the central carbon metabolism were determined by fractional (13)C-labeling and metabolic flux ratio analysis (MetaFoR) of the wild-type E. coli strain JM101 at an oxidative environment in a chemostat. We observed a significant increase in the flux through phosphoenolpyruvate carboxykinase (PEPCK), phosphoenolpyruvate carboxylase (PEPC), malic enzyme (MEZ) and serine hydroxymethyltransferase (SHMT). We applied an ε-constraint based multi-objective optimization to investigate the trade-off relationships between the biomass yield and the generation of reductive power using the in silico iJR904 genome-scale model of E. coli K-12. The theoretical metabolic redistribution supports that the trans-hydrogenase pathway should not play a direct role in the defence mounted by E. coli against oxidative stress. The agreement between the measured ratio and the theoretical redistribution established the significance of NADPH synthesis as the goal of the metabolic reprogramming that occurs in response to oxidative stress. Our work presents a framework that combines metabolic flux ratio analysis and multi-objective optimization to investigate the metabolic trade-offs that occur under varied environmental conditions. Our results led to the proposal that the metabolic response of E

  17. Denotation and connotation in public representation: Semantic network analysis of Hwang supporters' internet dialogues.

    Science.gov (United States)

    Kim, Leo

    2013-04-01

    This article analyzes the internet discourses of Korean people who supported Hwang Woo Suk despite the disclosure of his scientific misconduct. During the controversial period, those who supported Hwang constructed a narrative of a fallen hero trapped by jealous rivals and an "unjust" society. The supporters' dramatized discourses compete with expert opinions of Seoul National University's Audit Board and prosecutors that investigated the scientific fraud. By introducing and applying an innovative method of semantic network analysis, this study explores how the supporters represent their personal concerns in daily life and latent social problems in South Korea, as well as the failure of science communication. In short, the supporters' internet representations connote concerns in daily life that motivated their sympathy and activism for Hwang.

  18. SemanticSCo: A platform to support the semantic composition of services for gene expression analysis.

    Science.gov (United States)

    Guardia, Gabriela D A; Ferreira Pires, Luís; da Silva, Eduardo G; de Farias, Cléver R G

    2017-02-01

    Gene expression studies often require the combined use of a number of analysis tools. However, manual integration of analysis tools can be cumbersome and error prone. To support a higher level of automation in the integration process, efforts have been made in the biomedical domain towards the development of semantic web services and supporting composition environments. Yet, most environments consider only the execution of simple service behaviours and requires users to focus on technical details of the composition process. We propose a novel approach to the semantic composition of gene expression analysis services that addresses the shortcomings of the existing solutions. Our approach includes an architecture designed to support the service composition process for gene expression analysis, and a flexible strategy for the (semi) automatic composition of semantic web services. Finally, we implement a supporting platform called SemanticSCo to realize the proposed composition approach and demonstrate its functionality by successfully reproducing a microarray study documented in the literature. The SemanticSCo platform provides support for the composition of RESTful web services semantically annotated using SAWSDL. Our platform also supports the definition of constraints/conditions regarding the order in which service operations should be invoked, thus enabling the definition of complex service behaviours. Our proposed solution for semantic web service composition takes into account the requirements of different stakeholders and addresses all phases of the service composition process. It also provides support for the definition of analysis workflows at a high-level of abstraction, thus enabling users to focus on biological research issues rather than on the technical details of the composition process. The SemanticSCo source code is available at https://github.com/usplssb/SemanticSCo.

  19. Reliability Analysis for Tunnel Supports System by Using Finite Element Method

    Directory of Open Access Journals (Sweden)

    E. Bukaçi

    2016-09-01

    Full Text Available Reliability analysis is a method that can be used in almost any geotechnical engineering problem. Using this method requires the knowledge of parameter uncertainties, which can be expressed by their standard deviation value. By performing reliability analysis to tunnel supports design, can be obtained a range of safety factors and by using them, probability of failure can be calculated. Problem becomes more complex when this analysis is performed for numerical methods, such as Finite Element Method. This paper gives a solution to how reliability analysis can be performed to design tunnel supports, by using Point Estimate Method to calculate reliability index. As a case study, is chosen one of the energy tunnels at Fan Hydropower plant, in Rrëshen Albania. As results, values of factor of safety and probability of failure are calculated. Also some suggestions using reliability analysis with numerical methods are given.

  20. Space and Earth Sciences, Computer Systems, and Scientific Data Analysis Support, Volume 1

    Science.gov (United States)

    Estes, Ronald H. (Editor)

    1993-01-01

    This Final Progress Report covers the specific technical activities of Hughes STX Corporation for the last contract triannual period of 1 June through 30 Sep. 1993, in support of assigned task activities at Goddard Space Flight Center (GSFC). It also provides a brief summary of work throughout the contract period of performance on each active task. Technical activity is presented in Volume 1, while financial and level-of-effort data is presented in Volume 2. Technical support was provided to all Division and Laboratories of Goddard's Space Sciences and Earth Sciences Directorates. Types of support include: scientific programming, systems programming, computer management, mission planning, scientific investigation, data analysis, data processing, data base creation and maintenance, instrumentation development, and management services. Mission and instruments supported include: ROSAT, Astro-D, BBXRT, XTE, AXAF, GRO, COBE, WIND, UIT, SMM, STIS, HEIDI, DE, URAP, CRRES, Voyagers, ISEE, San Marco, LAGEOS, TOPEX/Poseidon, Pioneer-Venus, Galileo, Cassini, Nimbus-7/TOMS, Meteor-3/TOMS, FIFE, BOREAS, TRMM, AVHRR, and Landsat. Accomplishments include: development of computing programs for mission science and data analysis, supercomputer applications support, computer network support, computational upgrades for data archival and analysis centers, end-to-end management for mission data flow, scientific modeling and results in the fields of space and Earth physics, planning and design of GSFC VO DAAC and VO IMS, fabrication, assembly, and testing of mission instrumentation, and design of mission operations center.

  1. [Conservation Units.

    Science.gov (United States)

    Texas Education Agency, Austin.

    Each of the six instructional units deals with one aspect of conservation: forests, water, rangeland, minerals (petroleum), and soil. The area of the elementary school curriculum with which each correlates is indicated. Lists of general and specific objectives are followed by suggested teaching procedures, including ideas for introducing the…

  2. Seismic Response Analysis of Long-Span Suspen-Dome under Multi-Support Excitations

    Institute of Scientific and Technical Information of China (English)

    陈志华; 乔文涛; 王小盾

    2010-01-01

    A practical suspen-dome project, Changzhou Gym roof, is adopted as an example and its transient analysis based on the multi-support excitations of the earthquake wave is carried out. Compared with the single support excitation, the position and value of the maximum stress under multi-support excitations both change and the amount of elements with obvious changes is large and more than 70% of the total. Moreover, when other terms are not changed, this influence will decrease as the span decreases, but increa...

  3. Analysis of surface error correction capability of 1.2m active support system

    Science.gov (United States)

    Han, Yu; Fan, Bin; Li, Chaoqiang; Liu, Haitao

    2016-10-01

    The surface error correction ability is one of the important indicators to measure the performance of the active support system. In this paper, the correction force algorithm for the active support system of 1.2m thin meniscus mirror is introduced. Based on this algorithm, a simulation analysis is made. The simulation results show that the 1.2m active support system has excellent correction ability for Zernike polynomials term 4, 5, 6, 10 and 11, and has a good effect on the Zernike polynomials term 7 and 8.

  4. LANL Institutional Decision Support By Process Modeling and Analysis Group (AET-2)

    Energy Technology Data Exchange (ETDEWEB)

    Booth, Steven Richard [Los Alamos National Laboratory

    2016-04-04

    AET-2 has expertise in process modeling, economics, business case analysis, risk assessment, Lean/Six Sigma tools, and decision analysis to provide timely decision support to LANS leading to continuous improvement. This capability is critical during the current tight budgetary environment as LANS pushes to identify potential areas of cost savings and efficiencies. An important arena is business systems and operations, where processes can impact most or all laboratory employees. Lab-wide efforts are needed to identify and eliminate inefficiencies to accomplish Director McMillan’s charge of “doing more with less.” LANS faces many critical and potentially expensive choices that require sound decision support to ensure success. AET-2 is available to provide this analysis support to expedite the decisions at hand.

  5. Transcriptomic analysis of tail regeneration in the lizard Anolis carolinensis reveals activation of conserved vertebrate developmental and repair mechanisms.

    Science.gov (United States)

    Hutchins, Elizabeth D; Markov, Glenn J; Eckalbar, Walter L; George, Rajani M; King, Jesse M; Tokuyama, Minami A; Geiger, Lauren A; Emmert, Nataliya; Ammar, Michael J; Allen, April N; Siniard, Ashley L; Corneveaux, Jason J; Fisher, Rebecca E; Wade, Juli; DeNardo, Dale F; Rawls, J Alan; Huentelman, Matthew J; Wilson-Rawls, Jeanne; Kusumi, Kenro

    2014-01-01

    Lizards, which are amniote vertebrates like humans, are able to lose and regenerate a functional tail. Understanding the molecular basis of this process would advance regenerative approaches in amniotes, including humans. We have carried out the first transcriptomic analysis of tail regeneration in a lizard, the green anole Anolis carolinensis, which revealed 326 differentially expressed genes activating multiple developmental and repair mechanisms. Specifically, genes involved in wound response, hormonal regulation, musculoskeletal development, and the Wnt and MAPK/FGF pathways were differentially expressed along the regenerating tail axis. Furthermore, we identified 2 microRNA precursor families, 22 unclassified non-coding RNAs, and 3 novel protein-coding genes significantly enriched in the regenerating tail. However, high levels of progenitor/stem cell markers were not observed in any region of the regenerating tail. Furthermore, we observed multiple tissue-type specific clusters of proliferating cells along the regenerating tail, not localized to the tail tip. These findings predict a different mechanism of regeneration in the lizard than the blastema model described in the salamander and the zebrafish, which are anamniote vertebrates. Thus, lizard tail regrowth involves the activation of conserved developmental and wound response pathways, which are potential targets for regenerative medical therapies.

  6. Multicriteria analysis as a tool to investigate compatibility between conservation and development on Salina Island, Aeolian Archipelago, Italy

    Science.gov (United States)

    Bodini, Antonio; Giavelli, Giovanni

    1992-09-01

    Several multicriteria evaluation techniques have been developed since the 1970s. The need to compare different territorial policies has justified their introduction into environmental research. These methods are based on the numerical manipulation of heterogeneous information, which varies in terms of reference scale and type of measure (continuous, ordinal, qualitative, binary, etc.). During recent years, diverse investigations have focused on general conditions on Salina, the “green island” of the Aeolian archipelago. Such studies, within an interdisciplinary project, aimed to explore the possibility of implementing conservation strategies that are compatible with human needs, landscape preservation, and sustainable economic development. Three different evaluation techniques are applied, namely multicriteria weighted concordance and discordance analysis and a qualitative procedure. They are used to compare four alternative plans for the socioeconomic development of Salina Island. These plans lie between extreme alternatives: total protection of natural resources and maximizing economic development based on tourism. The plans are compared to each other on the basis of 14 criteria that reflect the socioenvironmental perception of Salina's inhabitants. The approach used in this research seems particularly fruitful because of its flexibility: it offers decision makers the chance to manage heterogeneous data and information that is not easily quantifiable. Such “soft” information helps to evaluate environmental conditions more precisely, and to make a less damaging choice among alternative development plans.

  7. Technique based on LED multispectral imaging and multivariate analysis for monitoring the conservation state of the Dead Sea Scrolls.

    Science.gov (United States)

    Marengo, Emilio; Manfredi, Marcello; Zerbinati, Orfeo; Robotti, Elisa; Mazzucco, Eleonora; Gosetti, Fabio; Bearman, Greg; France, Fenella; Shor, Pnina

    2011-09-01

    The aim of this project is the development of a noninvasive technique based on LED multispectral imaging (MSI) for monitoring the conservation state of the Dead Sea Scrolls (DSS) collection. It is well-known that changes in the parchment reflectance drive the transition of the scrolls from legible to illegible. Capitalizing on this fact, we will use spectral imaging to detect changes in the reflectance before they become visible to the human eye. The technique uses multivariate analysis and statistical process control theory. The present study was carried out on a "sample" parchment of calfskin. The monitoring of the surface of a commercial modern parchment aged consecutively for 2 h and 6 h at 80 °C and 50% relative humidity (ASTM) was performed at the Imaging Lab of the Library of Congress (Washington, DC, U.S.A.). MSI is here carried out in the vis-NIR range limited to 1 μm, with a number of bands of 13 and bandwidths that range from about 10 nm in UV to 40 nm in IR. Results showed that we could detect and locate changing pixels, on the basis of reflectance changes, after only a few "hours" of aging.

  8. Evaluation of soil and water conservation practices in the north-western Ethiopian highlands using multi-criteria analysis

    Directory of Open Access Journals (Sweden)

    Akalu eTeshome

    2014-12-01

    Full Text Available Investments by farmers in soil and water conservation (SWC practices are influenced by the physical effectiveness, financial efficiency and social acceptability of these practices. The objective of this study is to evaluate different SWC practices in the north-western highlands of Ethiopia using various qualitative criteria and weightings based on ecological, economic and social impacts using Multi-Criteria Analysis (MCA. The study reveals that MCA is a useful evaluation tool that takes into account non-monetary and less quantifiable effects of SWC practices. Farmers employ a range of criteria to evaluate the performance of SWC practices. The relative importance of each criterion in their selection of SWC alternatives depends mostly on slope categories. In steeply sloping areas, farmers assigned the highest score for criteria related to ecological impacts; whilst preferring practices with stronger positive economic impacts in moderate and gentle sloping areas. Policy makers and development practitioners are encouraged to pay greater attention to both farmer preferences and slope specific circumstances when designing SWC strategies and programmes.

  9. Transcriptomic analysis of tail regeneration in the lizard Anolis carolinensis reveals activation of conserved vertebrate developmental and repair mechanisms.

    Directory of Open Access Journals (Sweden)

    Elizabeth D Hutchins

    Full Text Available Lizards, which are amniote vertebrates like humans, are able to lose and regenerate a functional tail. Understanding the molecular basis of this process would advance regenerative approaches in amniotes, including humans. We have carried out the first transcriptomic analysis of tail regeneration in a lizard, the green anole Anolis carolinensis, which revealed 326 differentially expressed genes activating multiple developmental and repair mechanisms. Specifically, genes involved in wound response, hormonal regulation, musculoskeletal development, and the Wnt and MAPK/FGF pathways were differentially expressed along the regenerating tail axis. Furthermore, we identified 2 microRNA precursor families, 22 unclassified non-coding RNAs, and 3 novel protein-coding genes significantly enriched in the regenerating tail. However, high levels of progenitor/stem cell markers were not observed in any region of the regenerating tail. Furthermore, we observed multiple tissue-type specific clusters of proliferating cells along the regenerating tail, not localized to the tail tip. These findings predict a different mechanism of regeneration in the lizard than the blastema model described in the salamander and the zebrafish, which are anamniote vertebrates. Thus, lizard tail regrowth involves the activation of conserved developmental and wound response pathways, which are potential targets for regenerative medical therapies.

  10. Assessing Habitat Quality of Forest-Corridors through NDVI Analysis in Dry Tropical Forests of South India: Implications for Conservation

    Directory of Open Access Journals (Sweden)

    Paramesha Mallegowda

    2015-02-01

    Full Text Available Most wildlife habitats and migratory routes are extremely threatened due to increasing demands on forestland and forest resources by burgeoning human population. Corridor landscape in Biligiri Rangaswamy Temple Tiger Reserve (BRT is one among them, subjected to various anthropogenic pressures. Human habitation, intensive farming, coffee plantations, ill-planned infrastructure developments and rapid spreading of invasive plant species Lantana camara, pose a serious threat to wildlife habitat and their migration. Aim of this work is to create detailed NDVI based land change maps and to use them to identify time-series trends in greening and browning in forest corridors in the study area and to identify the drivers that are influencing the observed changes. Over the four decades in BRT, NDVI increased in the core area of the forest and reduced in the fringe areas. The change analysis between 1973 and 2014 shows significant changes; browning due to anthropogenic activities as well as natural processes and greening due to Lantana spread. This indicates that the change processes are complex, involving multiple driving factors, such as socio-economic changes, high population growth, historical forest management practices and policies. Our study suggests that the use of updated and accurate change detection maps will be useful in taking appropriate site specific action-oriented conservation decisions to restore and manage the degraded critical wildlife corridors in human-dominated landscape.

  11. Conservation of Male Sterility 2 function during spore and pollen wall development supports an evolutionarily early recruitment of a core component in the sporopollenin biosynthetic pathway.

    Science.gov (United States)

    Wallace, Simon; Chater, Caspar C; Kamisugi, Yasuko; Cuming, Andrew C; Wellman, Charles H; Beerling, David J; Fleming, Andrew J

    2015-01-01

    The early evolution of plants required the acquisition of a number of key adaptations to overcome physiological difficulties associated with survival on land. One of these was a tough sporopollenin wall that enclosed reproductive propagules and provided protection from desiccation and UV-B radiation. All land plants possess such walled spores (or their derived homologue, pollen). We took a reverse genetics approach, consisting of knock-out and complementation experiments to test the functional conservation of the sporopollenin-associated gene MALE STERILTY 2 (which is essential for pollen wall development in Arabidopsis thaliana) in the bryophyte Physcomitrella patens. Knock-outs of a putative moss homologue of the A. thaliana MS2 gene, which is highly expressed in the moss sporophyte, led to spores with highly defective walls comparable to that observed in the A. thaliana ms2 mutant, and extremely compromised germination. Conversely, the moss MS2 gene could not rescue the A. thaliana ms2 phenotype. The results presented here suggest that a core component of the biochemical and developmental pathway required for angiosperm pollen wall development was recruited early in land plant evolution but the continued increase in pollen wall complexity observed in angiosperms has been accompanied by divergence in MS2 gene function.

  12. Evolution of models to support community and policy action with science: Balancing pastoral livelihoods and wildlife conservation in savannas of East Africa.

    Science.gov (United States)

    Reid, R S; Nkedianye, D; Said, M Y; Kaelo, D; Neselle, M; Makui, O; Onetu, L; Kiruswa, S; Kamuaro, N Ole; Kristjanson, P; Ogutu, J; BurnSilver, S B; Goldman, M J; Boone, R B; Galvin, K A; Dickson, N M; Clark, W C

    2016-04-26

    We developed a "continual engagement" model to better integrate knowledge from policy makers, communities, and researchers with the goal of promoting more effective action to balance poverty alleviation and wildlife conservation in 4 pastoral ecosystems of East Africa. The model involved the creation of a core boundary-spanning team, including community facilitators, a policy facilitator, and transdisciplinary researchers, responsible for linking with a wide range of actors from local to global scales. Collaborative researcher-facilitator community teams integrated local and scientific knowledge to help communities and policy makers improve herd quality and health, expand biodiversity payment schemes, develop land-use plans, and fully engage together in pastoral and wildlife policy development. This model focused on the creation of hybrid scientific-local knowledge highly relevant to community and policy maker needs. The facilitation team learned to be more effective by focusing on noncontroversial livelihood issues before addressing more difficult wildlife issues, using strategic and periodic engagement with most partners instead of continual engagement, and reducing costs by providing new scientific information only when deemed essential. We conclude by examining the role of facilitation in redressing asymmetries in power in researcher-community-policy maker teams, the role of individual values and character in establishing trust, and how to sustain knowledge-action links when project funding ends.

  13. Use of Parsimony Analysis to Identify Areas of Endemism of Chinese Birds: Implications for Conservation and Biogeography

    Directory of Open Access Journals (Sweden)

    Xiao-Lei Huang

    2010-05-01

    Full Text Available Parsimony analysis of endemicity (PAE was used to identify areas of endemism (AOEs for Chinese birds at the subregional level. Four AOEs were identified based on a distribution database of 105 endemic species and using 18 avifaunal subregions as the operating geographical units (OGUs. The four AOEs are the Qinghai-Zangnan Subregion, the Southwest Mountainous Subregion, the Hainan Subregion and the Taiwan Subregion. Cladistic analysis of subregions generally supports the division of China’s avifauna into Palaearctic and Oriental realms. Two PAE area trees were produced from two different distribution datasets (year 1976 and 2007. The 1976 topology has four distinct subregional branches; however, the 2007 topology has three distinct branches. Moreover, three Palaearctic subregions in the 1976 tree clustered together with the Oriental subregions in the 2007 tree. Such topological differences may reflect changes in the distribution of bird species through circa three decades.

  14. Analysis of the ecological conservation behavior of farmers in payment for ecosystem service programs in eco-environmentally fragile areas using social psychology models.

    Science.gov (United States)

    Deng, Jian; Sun, Pingsheng; Zhao, Fazhu; Han, Xinhui; Yang, Gaihe; Feng, Yongzhong

    2016-04-15

    Studies on the ecological conservation behavior of farmers usually focus on individual and socio-economic characteristics without consideration of the underlying psychological constructs, such as farmers' intention and perceptions. This study uses the theory of planned behavior (TPB), a typical social psychology construct, to analyze the factors affecting the intention and behavior of farmers for conserving the ecological achievements from payment for ecosystem service (PES) programs in eco-environmentally fragile areas. Questionnaires based on TPB were administered to 1004 farmers from the Grain to Green Program area in the Loess Plateau, China, with the resulting dataset used to identify the underlying factors determining farmers' intention and behavior based on the structural equation model. The results show that the farmers' intention and behavior toward conserving ecological achievements were explained well by TPB. The farmers'behavior was significantly positively affected by their intention toward conserving ecological achievements, and their intention was significantly influenced by their attitude (positive or negative value of performance), the subjective norm (social pressure in engaging behavior), and perceived behavioral control (perceptions of their ability). The farmers' degree of support for PES programs and their recognition of environmental effects were the factors that most influenced the farmers' attitude. Pressure from neighbors was the most potent driver of the subjective norm. Meanwhile, perceptions of their ability to perform the behavior were the most potent factors affecting intention and it was mostly driven by the farmers' feelings toward environmental improvement and perceived ability (time and labor) to participate in ecological conservation. The drivers of attitude, subjective norm, and perceived behavioral control can be used by policy makers to direct farmers' intention and behavior toward conserving ecological achievements in fragile

  15. Performance test results of noninvasive characterization of Resource Conservation and Recovery Act surrogate waste by prompt gamma neutron activation analysis

    Energy Technology Data Exchange (ETDEWEB)

    Gehrke, R.J.; Streier, G.G.

    1997-03-01

    During FY-96, a performance test was carried out with funding from the Mixed Waste Focus Area (MWFA) of the Department of Energy (DOE) to determine the noninvasive elemental assay capabilities of commercial companies for Resource Conservation and Recovery Act (RCRA) metals present in 8-gal drums containing surrogate waste. Commercial companies were required to be experienced in the use of prompt gamma neutron activation analysis (PGNAA) techniques and to have a prototype assay system with which to conduct the test assays. Potential participants were identified through responses to a call for proposals advertised in the Commerce Business Daily and through personal contacts. Six companies were originally identified. Two of these six were willing and able to participate in the performance test, as described in the test plan, with some subsidizing from the DOE MWFA. The tests were conducted with surrogate sludge waste because (1) a large volume of this type of waste awaits final disposition and (2) sludge tends to be somewhat homogeneous. The surrogate concentrations of the above RCRA metals ranged from {approximately} 300 ppm to {approximately} 20,000 ppm. The lower limit was chosen as an estimate of the expected sensitivity of detection required by noninvasive, pretreatment elemental assay systems to be of value for operational and compliance purposes and to still be achievable with state-of-the-art methods of analysis. The upper limit of {approximately} 20,000 ppm was chosen because it is the opinion of the author that assay above this concentration level is within current state-of-the-art methods for most RCRA constituents. This report is organized into three parts: Part 1, Test Plan to Evaluate the Technical Status of Noninvasive Elemental Assay Techniques for Hazardous Waste; Part 2, Participants` Results; and Part 3, Evaluation of and Comments on Participants` Results.

  16. Single-cell time-lapse analysis of depletion of the universally conserved essential protein YgjD

    Directory of Open Access Journals (Sweden)

    Ackermann Martin

    2011-05-01

    Full Text Available Abstract Background The essential Escherichia coli gene ygjD belongs to a universally conserved group of genes whose function has been the focus of a number of recent studies. Here, we put ygjD under control of an inducible promoter, and used time-lapse microscopy and single cell analysis to investigate the phenotypic consequences of the depletion of YgjD protein from growing cells. Results We show that loss of YgjD leads to a marked decrease in cell size and termination of cell division. The transition towards smaller size occurs in a controlled manner: cell elongation and cell division remain coupled, but cell size at division decreases. We also find evidence that depletion of YgjD leads to the synthesis of the intracellular signaling molecule (pppGpp, inducing a cellular reaction resembling the stringent response. Concomitant deletion of the relA and spoT genes - leading to a strain that is uncapable of synthesizing (pppGpp - abrogates the decrease in cell size, but does not prevent termination of cell division upon YgjD depletion. Conclusions Depletion of YgjD protein from growing cells leads to a decrease in cell size that is contingent on (pppGpp, and to a termination of cell division. The combination of single-cell timelapse microscopy and statistical analysis can give detailed insights into the phenotypic consequences of the loss of essential genes, and can thus serve as a new tool to study the function of essential genes.

  17. Analysis of the kinematic and support properties of a longwall shield support on the example of the FAZOS-12/28-Oz support

    Energy Technology Data Exchange (ETDEWEB)

    Losiak, S.; Blaschke, J.; Krauze, K.; Ptak, J. (Akademia Gorniczo-Hutnicza, Cracow (Poland). Instytut Maszyn Gorniczych, Przerobczych i Automatyki)

    1992-07-01

    Proposes a mathematical model of the FAZOS-12/28-Oz lemniscate support and methods of calculating magnitudes characteristic of the functional properties of the support in its various exploitation conditions. The model and calculation results are provided. They allow permissible loads, forces at kinematic nodes of a support set, and its stability to be determined. The results can be represented graphically. They can also be useful in designing new support types. Kinematic diagrams of the basic parts of the support are shown. Variation of forces along a roof bar is shown in graphs. 5 refs.

  18. Defining Prolonged Length of Acute Care Stay for Surgically and Conservatively Treated Patients with Spontaneous Intracerebral Hemorrhage: A Population-Based Analysis

    Directory of Open Access Journals (Sweden)

    Marco Stein

    2016-01-01

    Full Text Available Background. The definition of prolonged length of stay (LOS during acute care remains unclear among surgically and conservatively treated patients with intracerebral hemorrhage (ICH. Methods. Using a population-based quality assessment registry, we calculated change points in LOS for surgically and conservatively treated patients with ICH. The influence of comorbidities, baseline characteristics at admission, and in-hospital complications on prolonged LOS was evaluated in a multivariate model. Results. Overall, 13272 patients with ICH were included in the analysis. Surgical therapy of the hematoma was documented in 1405 (10.6% patients. Change points for LOS were 22 days (CI: 8, 22; CL 98% for surgically treated patients and 16 days (CI: 16, 16; CL: 99% for conservatively treated patients. Ventilation therapy was related to prolonged LOS in surgically (OR: 2.2, 95% CI: 1.5–3.1; P<0.001 and conservatively treated patients (OR: 2.5, 95% CI: 2.2–2.9; P<0.001. Two or more in-hospital complications in surgical patients (OR: 2.7, 95% CI: 2.1–3.5 and ≥1 in conservative patients (OR: 3.0, 95% CI: 2.7–3.3 were predictors of prolonged LOS. Conclusion. The definition of prolonged LOS after ICH could be useful for several aspects of quality management and research. Preventing in-hospital complications could decrease the number of patients with prolonged LOS.

  19. Promiscuous prediction and conservancy analysis of CTL binding epitopes of HCV 3a viral proteome from Punjab Pakistan: an In Silico Approach

    Directory of Open Access Journals (Sweden)

    Idrees Muhammad

    2011-02-01

    Full Text Available Abstract Background HCV is a positive sense RNA virus affecting approximately 180 million people world wide and about 10 million Pakistani populations. HCV genotype 3a is the major cause of infection in Pakistani population. One of the major problems of HCV infection especially in the developing countries that limits the limits the antiviral therapy is the long term treatment, high dosage and side effects. Studies of antigenic epitopes of viral sequences of a specific origin can provide an effective way to overcome the mutation rate and to determine the promiscuous binders to be used for epitope based subunit vaccine design. An in silico approach was applied for the analysis of entire HCV proteome of Pakistani origin, aimed to identify the viral epitopes and their conservancy in HCV genotypes 1, 2 and 3 of diverse origin. Results Immunoinformatic tools were applied for the predictive analysis of HCV 3a antigenic epitopes of Pakistani origin. All the predicted epitopes were then subjected for their conservancy analysis in HCV genotypes 1, 2 and 3 of diverse origin (worldwide. Using freely available web servers, 150 MHC II epitopes were predicted as promiscuous binders against 51 subjected alleles. E2 protein represented the 20% of all the predicted MHC II epitopes. 75.33% of the predicted MHC II epitopes were (77-100% conserve in genotype 3; 47.33% and 40.66% in genotype 1 and 2 respectively. 69 MHC I epitopes were predicted as promiscuous binders against 47 subjected alleles. NS4b represented 26% of all the MHC I predicted epitopes. Significantly higher epitope conservancy was represented by genotype 3 i.e. 78.26% and 21.05% for genotype 1 and 2. Conclusions The study revealed comprehensive catalogue of potential HCV derived CTL epitopes from viral proteome of Pakistan origin. A considerable number of predicted epitopes were found to be conserved in different HCV genotype. However, the number of conserved epitopes in HCV genotype 3 was

  20. Integrating conservation costs into sea level rise adaptive conservation prioritization

    Directory of Open Access Journals (Sweden)

    Mingjian Zhu

    2015-07-01

    Full Text Available Biodiversity conservation requires strategic investment as resources for conservation are often limited. As sea level rises, it is important and necessary to consider both sea level rise and costs in conservation decision making. In this study, we consider costs of conservation in an integrated modeling process that incorporates a geomorphological model (SLAMM, species habitat models, and conservation prioritization (Zonation to identify conservation priorities in the face of landscape dynamics due to sea level rise in the Matanzas River basin of northeast Florida. Compared to conservation priorities that do not consider land costs in the analysis process, conservation priorities that consider costs in the planning process change significantly. The comparison demonstrates that some areas with high conservation values might be identified as lower priorities when integrating economic costs in the planning process and some areas with low conservation values might be identified as high priorities when considering costs in the planning process. This research could help coastal resources managers make informed decisions about where and how to allocate conservation resources more wisely to facilitate biodiversity adaptation to sea level rise.

  1. Heron conservation

    Science.gov (United States)

    Kushlan, J.A.; Hafner, H.

    2000-01-01

    Herons are large, popular and, in many cases, spectacular birds found in wetlands world-wide, both tropical and temperate, natural and man-made. Some populations are very small and localized, some have decreased, some have expanded their ranges, and a few are pests of human activities. In the fifteen years since the publication of the latest monographic treatment of the family, The Herons Handbook, there has been a tremendous increase in our knowledge of heron status and conservation requirements, set against a backdrop of increasing concern about the future of the world?s wetland habitats. This book provides a comprehensive update following two distinct threads. The status and conservation needs of herons are first presented on a regional basis, in a series of chapters set at a continental or subcontinental scale. Over 200 biologists and heron conservationists have contributed to the data summarized here, and the very latest census and survey results provide the most up-to-date and detailed picture of heron populations currently available. Chapters discussing several critical issues in heron conservation follow, tending to focus on the international nature of the problems.

  2. Modeling and analysis of energy conservation scheme based on duty cycling in wireless ad hoc sensor network.

    Science.gov (United States)

    Chung, Yun Won; Hwang, Ho Young

    2010-01-01

    In sensor network, energy conservation is one of the most critical issues since sensor nodes should perform a sensing task for a long time (e.g., lasting a few years) but the battery of them cannot be replaced in most practical situations. For this purpose, numerous energy conservation schemes have been proposed and duty cycling scheme is considered the most suitable power conservation technique, where sensor nodes alternate between states having different levels of power consumption. In order to analyze the energy consumption of energy conservation scheme based on duty cycling, it is essential to obtain the probability of each state. In this paper, we analytically derive steady state probability of sensor node states, i.e., sleep, listen, and active states, based on traffic characteristics and timer values, i.e., sleep timer, listen timer, and active timer. The effect of traffic characteristics and timer values on the steady state probability and energy consumption is analyzed in detail. Our work can provide sensor network operators guideline for selecting appropriate timer values for efficient energy conservation. The analytical methodology developed in this paper can be extended to other energy conservation schemes based on duty cycling with different sensor node states, without much difficulty.

  3. Modeling and Analysis of Energy Conservation Scheme Based on Duty Cycling in Wireless Ad Hoc Sensor Network

    Directory of Open Access Journals (Sweden)

    Yun Won Chung

    2010-06-01

    Full Text Available In sensor network, energy conservation is one of the most critical issues since sensor nodes should perform a sensing task for a long time (e.g., lasting a few years but the battery of them cannot be replaced in most practical situations. For this purpose, numerous energy conservation schemes have been proposed and duty cycling scheme is considered the most suitable power conservation technique, where sensor nodes alternate between states having different levels of power consumption. In order to analyze the energy consumption of energy conservation scheme based on duty cycling, it is essential to obtain the probability of each state. In this paper, we analytically derive steady state probability of sensor node states, i.e., sleep, listen, and active states, based on traffic characteristics and timer values, i.e., sleep timer, listen timer, and active timer. The effect of traffic characteristics and timer values on the steady state probability and energy consumption is analyzed in detail. Our work can provide sensor network operators guideline for selecting appropriate timer values for efficient energy conservation. The analytical methodology developed in this paper can be extended to other energy conservation schemes based on duty cycling with different sensor node states, without much difficulty.

  4. STARS - Supportability Trend Analysis and Reporting System for the National Space Transportation System

    Science.gov (United States)

    Graham, Leroy J.; Doempke, Gerald T.

    1990-01-01

    The concept, implementation, and long-range goals of a Supportability Trend Analysis and Reporting System (STARS) for the National Space Transportation System (NSTS) are discussed. The requirement was established as a direct result of the recommendations of the Rogers Commission investigation of the circumstances of the Space Shuttle Challenger accident. STARS outlines the requirements for the supportability-trend data collection, analysis, and reporting requirements that each of the project offices supporting the Space Shuttle are required to provide to the NSTS program office. STARS data give the historic and predictive logistics information necessary for all levels of NSTS management to make safe and cost-effective decisions concerning the smooth flow of Space Shuttle turnaround.

  5. Plastic zone analysis and support optimization of shallow roadway with weakly cemented soft strata

    Institute of Scientific and Technical Information of China (English)

    Zhang Jihua; Wang Lianguo; Li Qinghai; Zhu Shuangshuang

    2015-01-01

    Based on a shallow roadway with weakly cemented soft strata in western China, this paper studies the range and degree of plastic zones in soft strata roadways with weak cementation. Geological radars were used to monitor the loose range and level of surrounding rocks. A mechanical model of weakly cemented roadway was established, including granular material based on the measured results. The model was then used to determine the plastic zone radium. The predicted results agree well with measured results which provide valuable theoretical references for the analysis of surrounding rock stability and support reinforcing design of weakly cemented roadways. Finally, a combined supporting scheme of whole sec-tion bolting and grouting was proposed based on the original supporting scheme. It is proved that this support plan can effectively control the deformation and plastic zone expansion of the roadway sur-rounding rock and thus ensure the long-term stable and safe mining.

  6. Evaluation of SOVAT: An OLAP-GIS decision support system for community health assessment data analysis

    Directory of Open Access Journals (Sweden)

    Parmanto Bambang

    2008-06-01

    Full Text Available Abstract Background Data analysis in community health assessment (CHA involves the collection, integration, and analysis of large numerical and spatial data sets in order to identify health priorities. Geographic Information Systems (GIS enable for management and analysis using spatial data, but have limitations in performing analysis of numerical data because of its traditional database architecture. On-Line Analytical Processing (OLAP is a multidimensional datawarehouse designed to facilitate querying of large numerical data. Coupling the spatial capabilities of GIS with the numerical analysis of OLAP, might enhance CHA data analysis. OLAP-GIS systems have been developed by university researchers and corporations, yet their potential for CHA data analysis is not well understood. To evaluate the potential of an OLAP-GIS decision support system for CHA problem solving, we compared OLAP-GIS to the standard information technology (IT currently used by many public health professionals. Methods SOVAT, an OLAP-GIS decision support system developed at the University of Pittsburgh, was compared against current IT for data analysis for CHA. For this study, current IT was considered the combined use of SPSS and GIS ("SPSS-GIS". Graduate students, researchers, and faculty in the health sciences at the University of Pittsburgh were recruited. Each round consisted of: an instructional video of the system being evaluated, two practice tasks, five assessment tasks, and one post-study questionnaire. Objective and subjective measurement included: task completion time, success in answering the tasks, and system satisfaction. Results Thirteen individuals participated. Inferential statistics were analyzed using linear mixed model analysis. SOVAT was statistically significant (α = .01 from SPSS-GIS for satisfaction and time (p Conclusion Using SOVAT, tasks were completed more efficiently, with a higher rate of success, and with greater satisfaction, than the

  7. Meta-analysis of breast cancer microarray studies in conjunction with conserved cis-elements suggest patterns for coordinate regulation

    Directory of Open Access Journals (Sweden)

    Lundberg Cathryn

    2008-01-01

    Full Text Available Abstract Background Gene expression measurements from breast cancer (BrCa tumors are established clinical predictive tools to identify tumor subtypes, identify patients showing poor/good prognosis, and identify patients likely to have disease recurrence. However, diverse breast cancer datasets in conjunction with diagnostic clinical arrays show little overlap in the sets of genes identified. One approach to identify a set of consistently dysregulated candidate genes in these tumors is to employ meta-analysis of multiple independent microarray datasets. This allows one to compare expression data from a diverse collection of breast tumor array datasets generated on either cDNA or oligonucleotide arrays. Results We gathered expression data from 9 published microarray studies examining estrogen receptor positive (ER+ and estrogen receptor negative (ER- BrCa tumor cases from the Oncomine database. We performed a meta-analysis and identified genes that were universally up or down regulated with respect to ER+ versus ER- tumor status. We surveyed both the proximal promoter and 3' untranslated regions (3'UTR of our top-ranking genes in each expression group to test whether common sequence elements may contribute to the observed expression patterns. Utilizing a combination of known transcription factor binding sites (TFBS, evolutionarily conserved mammalian promoter and 3'UTR motifs, and microRNA (miRNA seed sequences, we identified numerous motifs that were disproportionately represented between the two gene classes suggesting a common regulatory network for the observed gene expression patterns. Conclusion Some of the genes we identified distinguish key transcripts previously seen in array studies, while others are newly defined. Many of the genes identified as overexpressed in ER- tumors were previously identified as expression markers for neoplastic transformation in multiple human cancers. Moreover, our motif analysis identified a collection of

  8. Analysis of Evidence Supporting the Educational Leadership Constituent Council 2011 Educational Leadership Program Standards

    Science.gov (United States)

    Tucker, Pamela D.; Anderson, Erin; Reynolds, Amy L.; Mawhinney, Hanne

    2016-01-01

    This document analysis provides a summary of the research from high-impact journals published between 2008 and 2013 with the explicit purpose of determining the extent to which the current empirical evidence supports the individual 2011 Educational Leadership Constituent Council Program Standards and their elements. We found that the standards are…

  9. Using concept mapping for needs analysis for a social support system in learning network

    NARCIS (Netherlands)

    Nadeem, Danish; Stoyanov, Slavi; Koper, Rob

    2011-01-01

    Nadeem, D., Stoyanov, S., & Koper, R. (2011). Using concept mapping for needs analysis for a social support system in learning network. International Journal of Interactive Mobile Technologies, 5(1), 41-45. Available on: http://online-journals.org/i-jim/issue/view/102

  10. Seeing, Believing, and Learning to Be Skeptical: Supporting Language Learning through Advertising Analysis Activities

    Science.gov (United States)

    Hobbs, Renee; He, Haixia; Robbgrieco, Michael

    2015-01-01

    This study documents how a high school ESL teacher working with new immigrants ages 14-20 supported the development of their critical thinking and English language skills by using advertising analysis activities. The article examines the use of key critical questions for analyzing media messages and documents instructional activities designed to…

  11. A fractionally cointegrated VAR analysis of economic voting and political support

    DEFF Research Database (Denmark)

    Jones, Maggie E. C.; Ørregård Nielsen, Morten; Popiel, Michael Ksawery

    We use a fractionally cointegrated vector autoregressive model to examine the relationship between Canadian political support and macroeconomic conditions. This model is well suited for the analysis because it allows multiple fractional time series and admits simple asymptotic inference for the m...

  12. Analysis to Support Execution of the Defense Environmental International Cooperation (DEIC) Program

    Science.gov (United States)

    2012-05-01

    IDA Document D-4605 May 2012 Analysis to Support Execution of the Defense Environmental International Cooperation ( DEIC ) Program Susan L. Clark...Execution of the Defense Environmental International Cooperation ( DEIC ) Program Susan L. Clark-Sestak iii Executive Summary The Defense...Environmental International Cooperation ( DEIC ) program is managed by the Director of Environmental Readiness and Safety (ERS) in the Office of the Deputy

  13. Multilingual Support for Lexicon-Based Sentiment Analysis Guided by Semantics

    NARCIS (Netherlands)

    Hogenboom, Alexander; Heerschop, Bas; Frasincar, Flavius; Kaymak, Uzay; Jong, de Franciska

    2014-01-01

    Many sentiment analysis methods rely on sentiment lexicons, containing words and their associated sentiment, and are tailored to one specific language. Yet, the ever-growing amount of data in different languages on the Web renders multi-lingual support increasingly important. In this paper, we asses

  14. Multi-lingual support for lexicon-based sentiment analysis guided by semantics

    NARCIS (Netherlands)

    A.C. Hogenboom (Alexander); B. Heerschop (Bas); F. Frasincar (Flavius); U. Kaymak (Uzay); F.M.G. de Jong (Franciska)

    2014-01-01

    markdownabstract__Abstract__ Many sentiment analysis methods rely on sentiment lexicons, containing words and their associated sentiment, and are tailored to one specific language. Yet, the ever-growing amount of data in different languages on the Web renders multi-lingual support increasingly impo

  15. 48 CFR 1415.404-2 - Information to support proposal analysis.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Information to support proposal analysis. 1415.404-2 Section 1415.404-2 Federal Acquisition Regulations System DEPARTMENT OF THE... General for Auditing for information....

  16. Finite element analysis of different loading conditions for implant-supported overdentures supported by conventional or mini implants.

    Science.gov (United States)

    Solberg, K; Heinemann, F; Pellikaan, P; Keilig, L; Stark, H; Bourauel, C; Hasan, I

    2017-03-10

    The effect of implants' number on overdenture stability and stress distribution in edentulous mandible, implants and overdenture was numerically investigated for implant-supported overdentures. Three models were constructed. Overdentures were connected to implants by means of ball head abutments and rubber ring. In model 1, the overdenture was retained by two conventional implants; in model 2, by four conventional implants; and in model 3, by five mini implants. The overdenture was subjected to a symmetrical load at an angle of 20 degrees to the overdenture at the canine regions and vertically at the first molars. Four different loading conditions with two total forces (120, 300 N) were considered for the numerical analysis. The overdenture displacement was about 2.2 times higher when five mini implants were used rather than four conventional implants. The lowest stress in bone bed was observed with four conventional implants. Stresses in bone were reduced by 61% in model 2 and by 6% in model 3 in comparison to model 1. The highest stress was observed with five mini implants. Stresses in implants were reduced by 76% in model 2 and 89% increased in model 3 compared to model 1. The highest implant displacement was observed with five mini implants. Implant displacements were reduced by 29% in model 2, and increased by 273% in model 3 compared to model 1. Conventional implants proved better stability for overdenture than mini implants. Regardless the type and number of implants, the stress within the bone and implants are below the critical limits.

  17. STABILITY ANALYSIS OF MAXWELL VISCOELASTIC PIPES CONVEYING FLUID WITH BOTH ENDS SIMPLY SUPPORTED

    Institute of Scientific and Technical Information of China (English)

    赵凤群; 王忠民; 冯振宇; 刘宏昭

    2001-01-01

    On the basis of some studies of elastic pipe conveying fluid, the dynamic behavior and stability of Maxwell viscoelastic pipes conveying fluid with both ends simply supported, which are gyroscopic conservative system, were investigated by using the finite difference method and the corresponding recurrence formula. The effect of relaxation time of viscoelastic materials on the variation curve between dimensionless flow velocity and the real part and imaginary part of dimensionless complex frequencies in the first-three-order modes were analyzed concretely. It is found that critical flow velocities of divergence instability of Maxwell viscoelastic pipes conveying fluid with both ends simply supported decrease with the decrease of the relaxation time, while after the onset of divergence instability(buckling)critical flow velocities of coupled-mode flutter increase with the decrease of the relaxation time. Particularly, in the case of greater mass ratio, with the decrease of relaxation time,the onset of coupled-mode flutter delays, and even does not take place. When the relaxation time is greater than 103 , stability behavior of viscoelastic pipes conveying fluid is almost similar to the elastic pipes conveying fluid.

  18. Interpreting support vector machine models for multivariate group wise analysis in neuroimaging.

    Science.gov (United States)

    Gaonkar, Bilwaj; T Shinohara, Russell; Davatzikos, Christos

    2015-08-01

    Machine learning based classification algorithms like support vector machines (SVMs) have shown great promise for turning a high dimensional neuroimaging data into clinically useful decision criteria. However, tracing imaging based patterns that contribute significantly to classifier decisions remains an open problem. This is an issue of critical importance in imaging studies seeking to determine which anatomical or physiological imaging features contribute to the classifier's decision, thereby allowing users to critically evaluate the findings of such machine learning methods and to understand disease mechanisms. The majority of published work addresses the question of statistical inference for support vector classification using permutation tests based on SVM weight vectors. Such permutation testing ignores the SVM margin, which is critical in SVM theory. In this work we emphasize the use of a statistic that explicitly accounts for the SVM margin and show that the null distributions associated with this statistic are asymptotically normal. Further, our experiments show that this statistic is a lot less conservative as compared to weight based permutation tests and yet specific enough to tease out multivariate patterns in the data. Thus, we can better understand the multivariate patterns that the SVM uses for neuroimaging based classification.

  19. Formal Analysis of an Agent Support Model for Behaviour Change Intervention

    Directory of Open Access Journals (Sweden)

    Ojeniyi Adegoke

    2016-12-01

    Full Text Available Agent applications have been widely used in behaviour change intervention nowadays. This is due to the four features of agents: proactive, reactivity, social ability and autonomy.  However, psychological reactance is one of the major limiting causes of agent interventions. Although, many studies have investigated into both psychological reactance and behaviour change nevertheless how reactive intervention can be supported to obtain an improved behaviour change intervention is still lacking in most previous studies. Therefore, this paper describes the formal analysis of agent support model for behaviour change intervention. The analysis made use of two widely accepted approaches in agent formal evaluation namely mathematical analysis and automated verification. The mathematical analysis examined the correctness of the formal model representation and formalization that aimed to ensure that all syntax and semantic representations used in the formal model is consistent. The mathematical analysis used equilibrium property to explore the formal model consistency. Likewise, automated verification depicts the checking of the model properties against its specifications and theoretical traces.  The automated verification used Temporal Trace Language (TTL, which verifies the model properties and states against generated traces. The paper presents an agent support model that allows building agent-based software and applications that deflect psychological reactance and enhance an improved behavioural change intervention.

  20. Thermal-Hydraulic Analysis Tasks for ANAV NPPs in Support of Plant Operation and Control

    Directory of Open Access Journals (Sweden)

    F. Reventós

    2008-01-01

    Full Text Available Thermal-hydraulic analysis tasks aimed at supporting plant operation and control of nuclear power plants are an important issue for the Asociación Nuclear Ascó-Vandellòs (ANAV. ANAV is the consortium that runs the Ascó power plants (2 units and the Vandellòs-II power plant. The reactors are Westinghouse-design, 3-loop PWRs with an approximate electrical power of 1000 MW. The Technical University of Catalonia (UPC thermal-hydraulic analysis team has jointly worked together with ANAV engineers at different levels in the analysis and improvement of these reactors. This article is an illustration of the usefulness of computational analysis for operational support. The contents presented were operational between 1985 and 2001 and subsequently changed slightly following various organizational adjustments. The paper has two different parts. In the first part, it describes the specific aspects of thermal-hydraulic analysis tasks related to operation and control and, in the second part, it briefly presents the results of three examples of analyses that were performed. All the presented examples are related to actual situations in which the scenarios were studied by analysts using thermal-hydraulic codes and prepared nodalizations. The paper also includes a qualitative evaluation of the benefits obtained by ANAV through thermal-hydraulic analyses aimed at supporting operation and plant control.

  1. Pattern Analysis and Decision Support for Cancer through Clinico-Genomic Profiles

    Science.gov (United States)

    Exarchos, Themis P.; Giannakeas, Nikolaos; Goletsis, Yorgos; Papaloukas, Costas; Fotiadis, Dimitrios I.

    Advances in genome technology are playing a growing role in medicine and healthcare. With the development of new technologies and opportunities for large-scale analysis of the genome, genomic data have a clear impact on medicine. Cancer prognostics and therapeutics are among the first major test cases for genomic medicine, given that all types of cancer are related with genomic instability. In this paper we present a novel system for pattern analysis and decision support in cancer. The system integrates clinical data from electronic health records and genomic data. Pattern analysis and data mining methods are applied to these integrated data and the discovered knowledge is used for cancer decision support. Through this integration, conclusions can be drawn for early diagnosis, staging and cancer treatment.

  2. Using stakeholder analysis to support moves towards universal coverage: lessons from the SHIELD project.

    Science.gov (United States)

    Gilson, Lucy; Erasmus, Ermin; Borghi, Jo; Macha, Janet; Kamuzora, Peter; Mtei, Gemini

    2012-03-01

    Stakeholder analysis is widely recommended as a tool for gathering insights on policy actor interests in, positions on, and power to influence, health policy issues. Such information is recognized to be critical in developing viable health policy proposals, and is particularly important for new health care financing proposals that aim to secure universal coverage (UC). However, there remain surprisingly few published accounts of the use of stakeholder analysis in health policy development generally, and health financing specifically, and even fewer that draw lessons from experience about how to do and how to use such analysis. This paper, therefore, aims to support those developing or researching UC reforms to think both about how to conduct stakeholder analysis, and how to use it to support evidence-informed pro-poor health policy development. It presents practical lessons and ideas drawn from experience of doing stakeholder analysis around UC reforms in South Africa and Tanzania, combined with insights from other relevant material. The paper has two parts. The first presents lessons of experience for conducting a stakeholder analysis, and the second, ideas about how to use the analysis to support policy design and the development of actor and broader political management strategies. Comparison of experience across South Africa and Tanzania shows that there are some commonalities concerning which stakeholders have general interests in UC reform. However, differences in context and in reform proposals generate differences in the particular interests of stakeholders and their likely positioning on reform proposals, as well as in their relative balance of power. It is, therefore, difficult to draw cross-national policy comparisons around these specific issues. Nonetheless, the paper shows that cross-national policy learning is possible around the approach to analysis, the factors influencing judgements and the implications for, and possible approaches to, management

  3. The General Mission Analysis Tool (GMAT): A New Resource for Supporting Debris Orbit Determination, Tracking and Analysis

    Science.gov (United States)

    Jah, Moriba; Huges, Steven; Wilkins, Matthew; Kelecy, Tom

    2009-03-01

    The General Mission Analysis Tool (GMAT) was initially developed at NASA's Goddard Space Flight Center (GSFC) as a high accuracy orbital analysis tool to support a variety of space missions. A formal agreement has recently been established between NASA and the Air Force Research Laboratory (AFRL) to further develop GMAT to include orbit determination (OD) capabilities. A variety of estimation strategies and dynamic models will be included in the new version of GMAT. GMAT will accommodate orbit determination, tracking and analysis of orbital debris through a combination of model, processing and implementation requirements. The GMAT processing architecture natively supports parallel processing such that allow it can efficiently accommodate the OD and tracking of numerous objects resulting from breakups. A full first release of the augmented GMAT capability is anticipated in September 2009 and it will be available for community use at no charge.

  4. Preliminary Stress Analysis of an IHX Tube Support Plate in Prototype SFR

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Sung Kyun; Koo, Gyeong Hoi [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2013-10-15

    In this paper, the structural integrity about the conceptual design of IHX tube support plate was reviewed and the design should be changed because of its high stress concentration at the outer rim area. For reducing its maximum stress, two alternatives were proposed and reviewed for the structural integrity point of view. In both proposing support designs, the maximum stress decreases up to the stress design limit. Tube support plates (TSPs) of the intermediate heat exchanger (IHX) in Prototype GenIV Sodium Cooled Fast Reactor (PGSFR) act to horizontally support IHX tubes against hydraulic loadings and they have numerous flow holes where a primary sodium flows downward and secondary sodium flows upward. Due to its many penetrations, its geometric shape is quite complex and structurally its integrity is quite weaker than other parts. In this study, we investigated the structural integrity of the conceptually designed IHX tube support plate. In addition, TSP's supporting concepts were proposed to increase its structural integrity, and confirmed its integrity by using a finite element analysis.

  5. Calorimetry, activity, and micro-FTIR analysis of CO chemisorption, titration, and oxidation on supported Pt

    Science.gov (United States)

    Sermon, Paul A.; Self, Valerie A.; Vong, Mariana S. W.; Wurie, Alpha T.

    1990-01-01

    The value of in situ analysis on CO chemisorption, titration and oxidation over supported Pt catalysts using calorimetry, catalytic and micro-FTIR methods is illustrated using silica- and titania-supported samples. Isothermal CO-O and O2-CO titrations have not been widely used on metal surfaces and may be complicated if some oxide supports are reduced by CO titrant. However, they can illuminate the kinetics of CO oxidation on metal/oxide catalysts since during such titrations all O and CO coverages are scanned as a function of time. There are clear advantages in following the rates of the catalyzed CO oxidation via calorimetry and gc-ms simultaneously. At lower temperatures the evidence they provide is complementary. CO oxidation and its catalysis of CO oxidation have been extensively studied with hysteresis and oscillations apparent, and the present results suggest the benefits of a combined approach. Silica support porosity may be important in defining activity-temperature hysteresis. FTIR microspectroscopy reveals the chemical heterogeneity of the catalytic surfaces used; it is interesting that the evidence with regard to the dominant CO surface species and their reactivities with regard to surface oxygen for present oxide-supported Pt are different from those seen on graphite-supported Pt.

  6. Analysis of mechanical interaction between human gluteal soft tissue and body supports.

    Science.gov (United States)

    Then, C; Menger, J; Benderoth, G; Alizadeh, M; Vogl, T J; Hübner, F; Silber, G

    2008-01-01

    Pressure sores are the most common complication associated with patient immobilization. They develop through sustained localized tissue strain and stress, primarily caused by body supports. Modifying support design can reduce the risk and extent of pressure sore development with computational simulations helping to provide insight into tissue stress-strain distribution. Appropriate material parameters for human soft tissue and support material, as well as precise anatomical modelling, are indispensable in this process. A finite element (FE) model of the human gluteal region based on magnetic resonance imaging (MRI) data has been developed. In vivo human gluteal skin/fat and muscle long-term material parameters as well as open-cell polyurethane foam support long-term material parameters have been characterised. The Ogden form for slightly compressible materials was employed to describe human gluteal soft tissue behaviour. Altering support geometries and support materials, effects on human gluteal soft tissue could be quantified. FE-analysis indicated maximal tissue stress at the muscle-bone interface, not at the skin. Shear strain maxima were found in the muscle layer near the fat-muscle interface. Maximum compressive stress magnitude at the sacral bone depended strongly on the behaviour of the pelvic diaphragm musculature. We hypothesize that the compliance of the muscles forming the pelvic diaphragm govern the relative motion of the buttock tissue to the adjacent bone structure under compression, thus influencing tissue stress magnitudes.

  7. Selecting method of districts with science and technology program's priority support and its positive analysis

    Institute of Scientific and Technical Information of China (English)

    WANG Hong-qi; WANG Xue-yuan

    2008-01-01

    According to growth pole theory, this paper puts forward that when allocating regional science and technology (S&T) innovation resources based on S&T program, should abide the principle that important are areceives priority support; Meanwhile, it designs method to ascertain district S&T advantage and S&T innovation resources utilizing efficiency as well as S&T developing speed by using component analysis and DEA method, and then constructs three-dimension selecting model ,by which a positive research on Heilongjiang is made, the purpose of which is to offer scientific method support and decision-making foundation for making regional S&T program.

  8. The Potential for Meta-Analysis to Support Decision Analysis in Ecology

    Science.gov (United States)

    Mengersen, Kerrie; MacNeil, M. Aaron; Caley, M. Julian

    2015-01-01

    Meta-analysis and decision analysis are underpinned by well-developed methods that are commonly applied to a variety of problems and disciplines. While these two fields have been closely linked in some disciplines such as medicine, comparatively little attention has been paid to the potential benefits of linking them in ecology, despite reasonable…

  9. mPed : a computer program for converting pedigree data to a format used by the PMx-software for conservation genetic analysis

    OpenAIRE

    Jansson, Mija; Ståhl, Ingvar; Laikre, Linda

    2013-01-01

    There is a growing need for conservation genetic management of animal populations when individual relatedness data (pedigrees) are available. Such data can be used to monitor rates of inbreeding and loss of genetic diversity. Traditionally, pedigree analysis for conservationmanagement has focused on zoo populations of threatened wild animals; available software has been developed in that context. Population Management x (PMx) is a free software for estimating genetic parameters including inbr...

  10. Analysis of Two Way Simply Supported Slabs With Central Sunk Using Finite Element Method

    Directory of Open Access Journals (Sweden)

    Chiranjeevi. M

    2014-09-01

    Full Text Available Majority of the sunken slabs are constructed with supporting beams, which leads to the uneconomy of the structure and difficult in arrangement of the centering work. In this view, it is considered to analyze a two way simply supported slab of different thicknesses with central sunk having one sunk depths.The objective of the paper is to analyze a two way simply supported slab having different thicknesses of 125,150,175,and 200mm with central sunk having depths of 250mm using Finite Element Analysis. This study significantly concludes that, adopting FE analysis using STAAD Pro for analysis of two-way sunken slab is advisable. By using FE analysis using STAAD Pro, we can avoid tedious and lengthy procedure of manual methods. From the chosen sunken slab it was observed that, there is decrease in sagging moments for sunk size of 0.25lx x 0.25ly with respect to two way slab without sunk.

  11. The Data Conservancy

    Science.gov (United States)

    Choudhury, S.; Duerr, R. E.

    2009-12-01

    NSF's Sustainable Digital Data Preservation and Access Network Partners program is an ambitious attempt to integrate a wide variety of expertise and infrastructure into a network for providing "reliable digital preservation, access, integration, and analysis capabilities for science." One of the first two DataNet award recipients, the Data Conservancy, is itself a network of widely diverse partners led by the libraries at the Johns Hopkins University. The Data Conservancy is built on existing exemplar scientific projects, communities, and virtual organizations that have deep engagement with their user communities, and extensive experience with large-scale distributed system development. Data Conservancy members embrace a shared vision that data curation is not an end, but rather a means to collect, organize, validate, and preserve data needed to address the grand research challenges that face society. Data Conservancy members holdings encompass the entire range of earth, life, and space science data. New to the Data Conservancy is the concept that University libraries will be part of the distributed network of data centers and that data science will become a path in the library and information science curricula. As noted by Winston Tabb (JHU Dean of Libraries) "Data Centers are the new library stacks."

  12. A tracking system for laboratory mice to support medical researchers in behavioral analysis.

    Science.gov (United States)

    Macrì, S; Mainetti, L; Patrono, L; Pieretti, S; Secco, A; Sergi, I

    2015-08-01

    The behavioral analysis of laboratory mice plays a key role in several medical and scientific research areas, such as biology, toxicology, pharmacology, and so on. Important information on mice behavior and their reaction to a particular stimulus is deduced from a careful analysis of their movements. Moreover, behavioral analysis of genetically modified mice allows obtaining important information about particular genes, phenotypes or drug effects. The techniques commonly adopted to support such analysis have many limitations, which make the related systems particularly ineffective. Currently, the engineering community is working to explore innovative identification and sensing technologies to develop new tracking systems able to guarantee benefits to animals' behavior analysis. This work presents a tracking solution based on passive Radio Frequency Identification Technology (RFID) in Ultra High Frequency (UHF) band. Much emphasis is given to the software component of the system, based on a Web-oriented solution, able to process the raw tracking data coming from a hardware system, and offer 2D and 3D tracking information as well as reports and dashboards about mice behavior. The system has been widely tested using laboratory mice and compared with an automated video-tracking software (i.e., EthoVision). The obtained results have demonstrated the effectiveness and reliability of the proposed solution, which is able to correctly detect the events occurring in the animals' cage, and to offer a complete and user-friendly tool to support researchers in behavioral analysis of laboratory mice.

  13. Comparative sequence and structure analysis reveals the conservation and diversity of nucleotide positions and their associated tertiary interactions in the riboswitches.

    Directory of Open Access Journals (Sweden)

    Sri D Appasamy

    Full Text Available The tertiary motifs in complex RNA molecules play vital roles to either stabilize the formation of RNA 3D structure or to provide important biological functionality to the molecule. In order to better understand the roles of these tertiary motifs in riboswitches, we examined 11 representative riboswitch PDB structures for potential agreement of both motif occurrences and conservations. A total of 61 unique tertiary interactions were found in the reference structures. In addition to the expected common A-minor motifs and base-triples mainly involved in linking distant regions the riboswitch structures three highly conserved variants of A-minor interactions called G-minors were found in the SAM-I and FMN riboswitches where they appear to be involved in the recognition of the respective ligand's functional groups. From our structural survey as well as corresponding structure and sequence alignments, the agreement between motif occurrences and conservations are very prominent across the representative riboswitches. Our analysis provide evidence that some of these tertiary interactions are essential components to form the structure where their sequence positions are conserved despite a high degree of diversity in other parts of the respective riboswitches sequences. This is indicative of a vital role for these tertiary interactions in determining the specific biological function of riboswitch.

  14. Aspects regarding analysis of the work deck from a support vessel

    Science.gov (United States)

    Axinte, T.; Nutu, C.; Stanca, C.; Cupsa, O.; Carp, A.

    2016-08-01

    The authors are presenting an analysis of the work deck only for the support vessel, a ship having in its structure among others: deck cranes and helicopter deck. The work deck is one of the most important parts of the support vessel's hull. We are starting the paper by presenting the role and the importance of the support vessel's type, by using an original execution drawing carried out using the Unigraphics NX 8.0 Software from Siemens.. Further on we can determine the shear, normal and the von Mises stresses pertaining to the work deck by using the finite element method. After determination of these stresses we can assess fatigue life, strength safety factor and fatigue safety factor. In order to determine the fatigue, the loading pattern only with the full unit cycle will be used. As for determining the safety factor only the ultimate strength stress criterion with the stress type von Mises from failure theories, will be used.

  15. Deployment-related mental health support: comparative analysis of NATO and allied ISAF partners

    Directory of Open Access Journals (Sweden)

    Eric Vermetten

    2014-08-01

    members. Conclusion: This analysis demonstrated that in all five partners state-of-the-art preventative mental healthcare was included in the last deployment in Afghanistan, including a positive approach towards strengthening the mental resilience, a focus on self-regulatory skills and self-empowerment, and several initiatives that were well-integrated in a military context. These initiatives were partly/completely implemented by the military/colleagues/supervisors and applicable during several phases of the deployment cycle. Important new developments in operational mental health support are recognition of the role of social leadership and enhancement of operational peer support. This requires awareness of mental problems that will contribute to reduction of the barriers to care in case of problems. Finally, comparing mental health support services across countries can contribute to optimal preparation for the challenges of military deployment.

  16. Service for victims of crime VDS info and victims’ support: Analysis of the previous work

    Directory of Open Access Journals (Sweden)

    Ćopić Sanja M.

    2004-01-01

    Full Text Available The first victim support service in our country VDS info and victims’ support started with its work in April 2003 within the Victimology Society of Serbia. This service is aimed at victims of crime (women and men, primarily at victims of violent crime, but also of some forms of property crime (such as burglary. The aim of the Service is to offer victims of crime information on their rights and the ways of how to realize them, emotional support, as well as to refer them to other institutions/organizations depending on the certain victim’s needs. Coordinators and volunteers, who passed the appropriate training, are responsible for that. Bearing that in mind, this paper will give the brief glens on the Service itself, its organization and the way of work, followed by the analysis of the results of previous work.

  17. SARA (System ARchitects Apprentice): Modeling, analysis, and simulation support for design of concurrent systems

    Energy Technology Data Exchange (ETDEWEB)

    Estrin, G.; Fenchel, R.S.; Razouk, R.R.; Vernon, M.K.

    1986-02-01

    An environment to support designers in the modeling, analysis and simulation of concurrent systems is described. It is shown how a fully nested structure model supports multilevel design and focuses attention on the interfaces between the modules which serve to encapsulate behavior. Using simple examples the paper indicates how a formal graph model can be used to model behavior in three domains: control flow, data flow, and interpretation. The effectiveness of the explicity environment model in SARA is discussed and the capability to analyze correctness and evaluate performance of a system model are demonstrated. A description of the integral help designed into SARA shows how the designer can be offered consistent use of any new tool introduced to support the design process.

  18. Hydrogen Safety Project chemical analysis support task: Window C'' volatile organic analysis

    Energy Technology Data Exchange (ETDEWEB)

    Gillespie, B.M.; Stromatt, R.W.; Ross, G.A.; Hoope, E.A.

    1992-01-01

    This data package contains the results obtained by Pacific Northwest Laboratory (PNL) staff in the characterization of samples for the 101-SY Hydrogen Safety Project. The samples were submitted for analysis by Westinghouse Hanford Company (WHC) under the Technical Project Plan (TPP) 17667 and the Quality Assurance Plan MCS-027. They came from a core taken during Window C'' after the May 1991 gas release event. The analytical procedures required for analysis were defined in the Test Instructions (TI) prepared by the PNL 101-SY Analytical Chemistry Laboratory (ACL) Project Management Office in accordance with the TPP and the QA Plan. The requested analysis for these samples was volatile organic analysis. The quality control (QC) requirements for each sample are defined in the Test Instructions for each sample. The QC requirements outlined in the procedures and requested in the WHC statement of work were followed.

  19. Hydrogen Safety Project chemical analysis support task: Window ``C`` volatile organic analysis

    Energy Technology Data Exchange (ETDEWEB)

    Gillespie, B.M.; Stromatt, R.W.; Ross, G.A.; Hoope, E.A.

    1992-01-01

    This data package contains the results obtained by Pacific Northwest Laboratory (PNL) staff in the characterization of samples for the 101-SY Hydrogen Safety Project. The samples were submitted for analysis by Westinghouse Hanford Company (WHC) under the Technical Project Plan (TPP) 17667 and the Quality Assurance Plan MCS-027. They came from a core taken during Window ``C`` after the May 1991 gas release event. The analytical procedures required for analysis were defined in the Test Instructions (TI) prepared by the PNL 101-SY Analytical Chemistry Laboratory (ACL) Project Management Office in accordance with the TPP and the QA Plan. The requested analysis for these samples was volatile organic analysis. The quality control (QC) requirements for each sample are defined in the Test Instructions for each sample. The QC requirements outlined in the procedures and requested in the WHC statement of work were followed.

  20. An analysis of the NIH-supported sickle cell disease research portfolio.

    Science.gov (United States)

    Gavini, Nara; Hoots, W Keith; Mensah, George A; Hanspal, Manjit

    2015-02-01

    Sickle cell disease (SCD), an inherited blood disorder is due to a single amino acid substitution on the beta chain of hemoglobin, and is characterized by anemia, severe infections, acute and chronic pain, and multi-organ damage. The National Institutes of Health (NIH) is dedicated to support basic, translational and clinical science research to improve care and ultimately, to find a cure for SCD that causes such suffering. This report provides a detailed analysis of grants funded by the NIH for SCD research in Fiscal Years 2007 through 2013. During this period, the NIH supported 247 de novo grants totaling $272,210,367 that address various aspects of SCD. 83% of these funds supported research project grants investigating the following 5 scientific themes: Pathology of Sickle Red Blood Cells; Globin Gene Expression; Adhesion and Vascular Dysfunction; Neurological Complications and Organ-specific Dysfunction; and Pain Management and Intervention. The remaining 17% of total funds supported career development and training grants; Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) grants; large Center grants; and Conference grants. Further analysis showed that the National Heart, Lung, and Blood Institute (NHLBI) is the largest funder of SCD research within NIH with 67% of total grants, contributing 77% of total funds; followed by the National Institute for Digestive Diseases and Kidney (NIDDK) that is funding 19% of grants, contributing 13% of total funds. The remaining 14% of grants totaling 10% of the funds were supported by all other NIH Institutes/Centers (ICs) combined. In summary, the NIH is using multiple funding mechanisms to support a sickle cell disease research agenda that is intended to advance the detection, treatment, and cure of this debilitating genetic disease.

  1. Integrated support for medical image analysis methods: from development to clinical application.

    Science.gov (United States)

    Olabarriaga, Sílvia D; Snel, Jeroen G; Botha, Charl P; Belleman, Robert G

    2007-01-01

    Computer-aided image analysis is becoming increasingly important to efficiently and safely handle large amounts of high-resolution images generated by advanced medical imaging devices. The development of medical image analysis (MIA) software with the required properties for clinical application, however, is difficult and labor-intensive. Such development should be supported by systems providing scalable computational capacity and storage space, as well as information management facilities. This paper describes the properties of distributed systems to support and facilitate the development, evaluation, and clinical application of MIA methods. First, the main characteristics of existing systems are presented. Then, the phases in a method's lifecycle are analyzed (development, parameter optimization, evaluation, clinical routine), identifying the types of users, tasks, and related computational issues. A scenario is described where all tasks are performed with the aid of computational tools integrated into an ideal supporting environment. The requirements for this environment are described, proposing a grid-oriented paradigm that emphasizes virtual collaboration among users, pieces of software, and devices distributed among geographically dispersed healthcare, research, and development enterprises. Finally, the characteristics of the existing systems are analyzed according to these requirements. The proposed requirements offer a useful framework to evaluate, compare, and improve the existing systems that support MIA development.

  2. Image data integration and analysis for natural disaster decision support systems

    Science.gov (United States)

    Roper, William E.

    2001-06-01

    Natural disasters have a major impact, globally and within the United States causing injury and loss of life, as well as economic losses. To better address disaster response needs, a task force has been established to leverage technological capabilities to improve disaster response management. Web based geospatial analysis is one of these important capabilities. Samples of geospatial technologies applicable to disaster management are presented. These include 3D visualization, hyperspectral imagery, LIDAR, use of spectral libraries, digital multispectral video, radar imaging systems, photogeologic analysis and geographic information systems. An example scenario of a hurricane with landfall at Mobile, Alabama is used to demonstrate the interoperable use of web-based geospatial information to support decision support systems and assist public information communication.

  3. Vibration reliability analysis for aeroengine compressor blade based on support vector machine response surface method

    Institute of Scientific and Technical Information of China (English)

    GAO Hai-feng; BAI Guang-chen

    2015-01-01

    To ameliorate reliability analysis efficiency for aeroengine components, such as compressor blade, support vector machine response surface method (SRSM) is proposed. SRSM integrates the advantages of support vector machine (SVM) and traditional response surface method (RSM), and utilizes experimental samples to construct a suitable response surface function (RSF) to replace the complicated and abstract finite element model. Moreover, the randomness of material parameters, structural dimension and operating condition are considered during extracting data so that the response surface function is more agreeable to the practical model. The results indicate that based on the same experimental data, SRSM has come closer than RSM reliability to approximating Monte Carlo method (MCM); while SRSM (17.296 s) needs far less running time than MCM (10958 s) and RSM (9840 s). Therefore, under the same simulation conditions, SRSM has the largest analysis efficiency, and can be considered a feasible and valid method to analyze structural reliability.

  4. Applying behavior analysis to school violence and discipline problems: Schoolwide positive behavior support.

    Science.gov (United States)

    Anderson, Cynthia M; Kincaid, Donald

    2005-01-01

    School discipline is a growing concern in the United States. Educators frequently are faced with discipline problems ranging from infrequent but extreme problems (e.g., shootings) to less severe problems that occur at high frequency (e.g., bullying, insubordination, tardiness, and fighting). Unfortunately, teachers report feeling ill prepared to deal effectively with discipline problems in schools. Further, research suggests that many commonly used strategies, such as suspension, expulsion, and other reactive strategies, are not effective for ameliorating discipline problems and may, in fact, make the situation worse. The principles and technology of behavior analysis have been demonstrated to be extremely effective for decreasing problem behavior and increasing social skills exhibited by school children. Recently, these principles and techniques have been applied at the level of the entire school, in a movement termed schoolwide positive behavior support. In this paper we review the tenets of schoolwide positive behavior support, demonstrating the relation between this technology and applied behavior analysis.

  5. NREL's Field Data Repository Supports Accurate Home Energy Analysis (Fact Sheet)

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2012-02-01

    This fact sheet discusses NREL's work to develop a repository of research-level residential building characteristics and historical energy use data to support ongoing efforts to improve the accuracy of residential energy analysis tools and the efficiency of energy assessment processes. The objective of this project is to create a robust empirical data source to support the research goals of the Department of Energy's Building America program, which is to improve the efficiency of existing U.S. homes by 30% to 50%. Researchers can use this data source to test the accuracy of building energy simulation software and energy audit procedures, ultimately leading to more credible and less expensive energy analysis.

  6. Supporting service differentiation with enhancements of the IEEE 802.11 MAC protocol: Models and analysis

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    As one of the fastest growing wireless access technologies, wireless LANs must evolve to support adequate degrees of service differentiation. Unfortunately, current WLAN standards like IEEE 802.11 Distributed Coordination Function (DCF) lack this ability. Work is in progress to define an enhanced version capable of supporting QoS for multimedia traffic at the MAC layer. In this paper, we aim at gaining insight into three mechanisms to differentiate among traffic categories, i.e., differentiating the minimum contention window size, the Inter-Frame Spacing (IFS), and the length of the packet payload according to the priority of different traffic categories. We propose an analysis model to compute the throughput and packet transmission delays. In addition, we derive approximations to obtain simpler but more meaningful relationships among different parameters. Comparisons with discrete-event simulation results show that good accuracy of performance evaluation can be achieved by using the proposed analysis model.

  7. Electrocardiogram Pattern Recognition and Analysis Based on Artificial Neural Networks and Support Vector Machines: A Review

    Directory of Open Access Journals (Sweden)

    Mario Sansone

    2013-01-01

    Full Text Available Computer systems for Electrocardiogram (ECG analysis support the clinician in tedious tasks (e.g., Holter ECG monitored in Intensive Care Units or in prompt detection of dangerous events (e.g., ventricular fibrillation. Together with clinical applications (arrhythmia detection and heart rate variability analysis, ECG is currently being investigated in biometrics (human identification, an emerging area receiving increasing attention. Methodologies for clinical applications can have both differences and similarities with respect to biometrics. This paper reviews methods of ECG processing from a pattern recognition perspective. In particular, we focus on features commonly used for heartbeat classification. Considering the vast literature in the field and the limited space of this review, we dedicated a detailed discussion only to a few classifiers (Artificial Neural Networks and Support Vector Machines because of their popularity; however, other techniques such as Hidden Markov Models and Kalman Filtering will be also mentioned.

  8. Participatory soil and water conservation planning using a financial analysis tool in the west usambara highlands of tanzania

    NARCIS (Netherlands)

    Tenge, A.J.M.; Okoba, B.O.; Sterk, G.

    2007-01-01

    Despite decades of soil and water conservation (SWC) efforts in Tanzania, the adoption of the recommended SWC measures by farmers is minimal. In the past, SWC plans did not incorporate farmers' knowledge, and the economics of SWC was not given much attention at the planning stage. This research eval

  9. The effect of age in breast conserving therapy : A retrospective analysis on pathology and clinical outcome data

    NARCIS (Netherlands)

    Chen, Wei; Sonke, Jan-Jakob; Stroom, Joep; Bartelink, Harry; Verheij, Marcel; Gilhuijs, Kenneth

    2015-01-01

    Background and propose: Age is an important prognostic marker of patient outcome after breast conserving therapy; however, it is not clear how age affects the outcome. This study aimed to explore the relationship between age with the cell quantity and the radiosensitivity of microscopic disease (MSD

  10. Is international conservation aid enough?

    Science.gov (United States)

    Law, Elizabeth A.

    2016-02-01

    Bare et al (2015 Environ. Res. Lett. 10 125010) ask an important question: is international conservation enough? Since the 1990’s international conservation donors have spent over 3.4 billion on biodiversity conservation related projects in sub-Saharan Africa. Both donors and recipients have a right to know if this is effective. Surprisingly, this question is rarely asked. It is a difficult question—involving many rival social, environmental, and economic explanations. Bare, Kauffman and Miller uncover some interesting associations, supporting existing hypotheses and proposing their own: that conservation aid alone is insufficient to mitigate drivers of deforestation (and in some cases may even exacerbate forest loss). This controversial result warrants further investigation—but what is needed now is nuance and robustness in further analyses, to have more confidence in the critique and it’s implications for international conservation aid.

  11. Landscape Conservative Cooperatives for New Mexico

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Landscape conservation cooperatives (LCCs) are conservation-science partnerships between the U.S. Fish and Wildlife Service, U.S. Geological Survey (USGS), and other...

  12. Analysis of logistical support as the key link of military logistics

    Directory of Open Access Journals (Sweden)

    Артем Володимирович Зозуля

    2016-11-01

    Full Text Available The analysis of the specific logistic support in terms of military logistics is proposed in the article. Special attention is addressed to legal regulation of financial and business activity of military units in logistics processes. The special role of prime importance of the formation of the corresponding moral - psychological model of military personnel of military units and subunits are noted. The specifics of the formation of military logistics systems in current economic conditions is analyzed

  13. Kinematic Analysis of Cpm Machine Supporting to Rehabilitation Process after Surgical Knee Arthroscopy and Arthroplasty

    Science.gov (United States)

    Trochimczuk, R.; Kuźmierowski, T.

    2014-11-01

    Existing commercial solutions of the CPM (Continuous Passive Motion) machines are described in the paper. Based on the analysis of existing solutions we present our conceptual solution to support the process of rehabilitation of the knee joint which is necessary after arthroscopic surgery. For a given novel structure we analyze and present proprietary algorithms and the computer application to simulate the operation of our PCM device. In addition, we suggest directions for further research.

  14. Deflection and Supporting Force Analysis of a Slender Beam under Combined Transverse and Tensile Axial Loads

    Science.gov (United States)

    2016-05-01

    supporting force analysis of a static pressure pipe that is to be used in the Defence Science and Technology Group Transonic Wind Tunnel test...Technology Group Transonic Wind Tunnel test facility. The static pressure pipe analysed herein was modelled as a slender propped cantilever beam...the Defence Science and Technology Group Transonic Wind Tunnel facility. A layout diagram of the static pressure pipe installation is shown in

  15. Mixture gas component concentration analysis based on support vector machine and infrared spectrum

    Institute of Scientific and Technical Information of China (English)

    Peng Bai; Junhua Liu

    2006-01-01

    @@ A novel quantitative analysis method of multi-component mixture gas concentration based on support vector machine (SVM) and spectroscopy is proposed. Through transformation of the kernel function, the seriously overlapped and nonlinear spectrum data are transformed in high-dimensional space, but the highdimensional data can be processed in the original space. Some factors, such as kernel function, range of the wavelength, and penalty coefficient, are discussed. This method is applied to the quantitative analysis of natural gas components concentration, and the component concentration maximal deviation is 2.28%.

  16. Analysis of Two-Level Support Systems with Time-Dependent Overflow - A Banking Application

    DEFF Research Database (Denmark)

    Barth, Wolfgang; Manitz, Michael; Stolletz, Raik

    2010-01-01

    is available. The analysis of such a system with time-dependent overflow is reduced to the analysis of a continuous-time Markov chain with state-dependent overflow probabilities. To approximate the system with time-dependent overflow, some waiting-based performance measures are modified. Numerical results......In this paper, we analyze the performance of call centers of financial service providers with two levels of support and a time-dependent overflow mechanism. Waiting calls from the front-office queue flow over to the back office if a waiting-time limit is reached and at least one back-office agent...

  17. Thermal-Hydraulic Analysis Tasks for ANAV NPPs in Support of Plant Operation and Control

    OpenAIRE

    2007-01-01

    Thermal-hydraulic analysis tasks aimed at supporting plant operation and control of nuclear power plants are an important issue for the Asociación Nuclear Ascó-Vandellòs (ANAV). ANAV is the consortium that runs the Ascó power plants (2 units) and the Vandellòs-II power plant. The reactors are Westinghouse-design, 3-loop PWRs with an approximate electrical power of 1000 MW. The Technical University of Catalonia (UPC) thermal-hydraulic analysis team has jointly worked togeth...

  18. On-line analysis capabilities developed to support the AFW wind-tunnel tests

    Science.gov (United States)

    Wieseman, Carol D.; Hoadley, Sherwood T.; Mcgraw, Sandra M.

    1992-01-01

    A variety of on-line analysis tools were developed to support two Active Flexible Wing wind-tunnel tests. These tools were developed to verify control law execution, to satisfy analysis requirements of the control law designers, to provide measures of system stability in a real-time environment, and to provide project managers with a quantitative measure of controller performance. Description and purposes of capabilities which were developed are presented in this paper along with examples. Procedures for saving and transferring data for near real-time analysis, and descriptions of the corresponding data interface programs are also presented. The on-line analysis tools worked well before, during, and after the wind-tunnel tests and proved to be a vital and important part of the entire test effort.

  19. Supercritical fluid chromatography for GMP analysis in support of pharmaceutical development and manufacturing activities.

    Science.gov (United States)

    Hicks, Michael B; Regalado, Erik L; Tan, Feng; Gong, Xiaoyi; Welch, Christopher J

    2016-01-05

    Supercritical fluid chromatography (SFC) has long been a preferred method for enantiopurity analysis in support of pharmaceutical discovery and development, but implementation of the technique in regulated GMP laboratories has been somewhat slow, owing to limitations in instrument sensitivity, reproducibility, accuracy and robustness. In recent years, commercialization of next generation analytical SFC instrumentation has addressed previous shortcomings, making the technique better suited for GMP analysis. In this study we investigate the use of modern SFC for enantiopurity analysis of several pharmaceutical intermediates and compare the results with the conventional HPLC approaches historically used for analysis in a GMP setting. The findings clearly illustrate that modern SFC now exhibits improved precision, reproducibility, accuracy and robustness; also providing superior resolution and peak capacity compared to HPLC. Based on these findings, the use of modern chiral SFC is recommended for GMP studies of stereochemistry in pharmaceutical development and manufacturing.

  20. Conservation priorities for Prunus africana defined with the aid of spatial analysis of genetic data and climatic variables.

    Directory of Open Access Journals (Sweden)

    Barbara Vinceti

    Full Text Available Conservation priorities for Prunus africana, a tree species found across Afromontane regions, which is of great commercial interest internationally and of local value for rural communities, were defined with the aid of spatial analyses applied to a set of georeferenced molecular marker data (chloroplast and nuclear microsatellites from 32 populations in 9 African countries. Two approaches for the selection of priority populations for conservation were used, differing in the way they optimize representation of intra-specific diversity of P. africana across a minimum number of populations. The first method (S1 was aimed at maximizing genetic diversity of the conservation units and their distinctiveness with regard to climatic conditions, the second method (S2 at optimizing representativeness of the genetic diversity found throughout the species' range. Populations in East African countries (especially Kenya and Tanzania were found to be of great conservation value, as suggested by previous findings. These populations are complemented by those in Madagascar and Cameroon. The combination of the two methods for prioritization led to the identification of a set of 6 priority populations. The potential distribution of P. africana was then modeled based on a dataset of 1,500 georeferenced observations. This enabled an assessment of whether the priority populations identified are exposed to threats from agricultural expansion and climate change, and whether they are located within the boundaries of protected areas. The range of the species has been affected by past climate change and the modeled distribution of P. africana indicates that the species is likely to be negatively affected in future, with an expected decrease in distribution by 2050. Based on these insights, further research at the regional and national scale is recommended, in order to strengthen P. africana conservation efforts.

  1. Conservation priorities for Prunus africana defined with the aid of spatial analysis of genetic data and climatic variables.

    Science.gov (United States)

    Vinceti, Barbara; Loo, Judy; Gaisberger, Hannes; van Zonneveld, Maarten J; Schueler, Silvio; Konrad, Heino; Kadu, Caroline A C; Geburek, Thomas

    2013-01-01

    Conservation priorities for Prunus africana, a tree species found across Afromontane regions, which is of great commercial interest internationally and of local value for rural communities, were defined with the aid of spatial analyses applied to a set of georeferenced molecular marker data (chloroplast and nuclear microsatellites) from 32 populations in 9 African countries. Two approaches for the selection of priority populations for conservation were used, differing in the way they optimize representation of intra-specific diversity of P. africana across a minimum number of populations. The first method (S1) was aimed at maximizing genetic diversity of the conservation units and their distinctiveness with regard to climatic conditions, the second method (S2) at optimizing representativeness of the genetic diversity found throughout the species' range. Populations in East African countries (especially Kenya and Tanzania) were found to be of great conservation value, as suggested by previous findings. These populations are complemented by those in Madagascar and Cameroon. The combination of the two methods for prioritization led to the identification of a set of 6 priority populations. The potential distribution of P. africana was then modeled based on a dataset of 1,500 georeferenced observations. This enabled an assessment of whether the priority populations identified are exposed to threats from agricultural expansion and climate change, and whether they are located within the boundaries of protected areas. The range of the species has been affected by past climate change and the modeled distribution of P. africana indicates that the species is likely to be negatively affected in future, with an expected decrease in distribution by 2050. Based on these insights, further research at the regional and national scale is recommended, in order to strengthen P. africana conservation efforts.

  2. Integrated opto-mechanical optimization analysis of large-aperture primary mirror's support position

    Science.gov (United States)

    Ke, Ding; Bo, Qi; Jiang, Bian

    2016-10-01

    Large mirror's support position plays a very important role in optical system's wave-front error. This paper took a Φ1.2m diameter primary mirror as an example and introduced the method of integrated opto-mechanical optimization analysis, then structure's parametric model in Proe, finite element's parametric model in Patran, structure analysis in Nastran and opto-mechanical coupling analysis in Sigfit were integrated as a fully automatic process in Isight by use of command streams and result documents produced by these soft wares. After the process was established and verified, automatic gradient searches of primary mirror's optimal support position were conducted using optimizer embedded in Isight. The optimization objective is the minimum of surface error's RMS and the optimization variables are support positions. New searches can easily be conducted repeatedly after mirror's model is modified in the structure parameter document. Because of the search process is fully automatic, manpower and computing time are greatly saved. This example also provides a good reference for problems in opto-mechanical fields.

  3. The Statistical Analysis Techniques to Support the NGNP Fuel Performance Experiments

    Energy Technology Data Exchange (ETDEWEB)

    Bihn T. Pham; Jeffrey J. Einerson

    2010-06-01

    This paper describes the development and application of statistical analysis techniques to support the AGR experimental program on NGNP fuel performance. The experiments conducted in the Idaho National Laboratory’s Advanced Test Reactor employ fuel compacts placed in a graphite cylinder shrouded by a steel capsule. The tests are instrumented with thermocouples embedded in graphite blocks and the target quantity (fuel/graphite temperature) is regulated by the He-Ne gas mixture that fills the gap volume. Three techniques for statistical analysis, namely control charting, correlation analysis, and regression analysis, are implemented in the SAS-based NGNP Data Management and Analysis System (NDMAS) for automated processing and qualification of the AGR measured data. The NDMAS also stores daily neutronic (power) and thermal (heat transfer) code simulation results along with the measurement data, allowing for their combined use and comparative scrutiny. The ultimate objective of this work includes (a) a multi-faceted system for data monitoring and data accuracy testing, (b) identification of possible modes of diagnostics deterioration and changes in experimental conditions, (c) qualification of data for use in code validation, and (d) identification and use of data trends to support effective control of test conditions with respect to the test target. Analysis results and examples given in the paper show the three statistical analysis techniques providing a complementary capability to warn of thermocouple failures. It also suggests that the regression analysis models relating calculated fuel temperatures and thermocouple readings can enable online regulation of experimental parameters (i.e. gas mixture content), to effectively maintain the target quantity (fuel temperature) within a given range.

  4. Applying Qualitative Hazard Analysis to Support Quantitative Safety Analysis for Proposed Reduced Wake Separation Conops

    Science.gov (United States)

    Shortle, John F.; Allocco, Michael

    2005-01-01

    This paper describes a scenario-driven hazard analysis process to identify, eliminate, and control safety-related risks. Within this process, we develop selective criteria to determine the applicability of applying engineering modeling to hypothesized hazard scenarios. This provides a basis for evaluating and prioritizing the scenarios as candidates for further quantitative analysis. We have applied this methodology to proposed concepts of operations for reduced wake separation for closely spaced parallel runways. For arrivals, the process identified 43 core hazard scenarios. Of these, we classified 12 as appropriate for further quantitative modeling, 24 that should be mitigated through controls, recommendations, and / or procedures (that is, scenarios not appropriate for quantitative modeling), and 7 that have the lowest priority for further analysis.

  5. Computational analysis and determination of a highly conserved surface exposed segment in H5N1 avian flu and H1N1 swine flu neuraminidase

    Directory of Open Access Journals (Sweden)

    Nandy Ashesh

    2010-02-01

    Full Text Available Abstract Background Catalytic activity of influenza neuraminidase (NA facilitates elution of progeny virions from infected cells and prevents their self-aggregation mediated by the catalytic site located in the body region. Research on the active site of the molecule has led to development of effective inhibitors like oseltamivir, zanamivir etc, but the high rate of mutation and interspecies reassortment in viral sequences and the recent reports of oseltamivir resistant strains underlines the importance of determining additional target sites for developing future antiviral compounds. In a recent computational study of 173 H5N1 NA gene sequences we had identified a 50-base highly conserved region in 3'-terminal end of the NA gene. Results We extend the graphical and numerical analyses to a larger number of H5N1 NA sequences (514 and H1N1 swine flu sequences (425 accessed from GenBank. We use a 2D graphical representation model for the gene sequences and a Graphical Sliding Window Method (GSWM for protein sequences scanning the sequences as a block of 16 amino acids at a time. Using a protein sequence descriptor defined in our model, the protein sliding scan method allowed us to compare the different strains for block level variability, which showed significant statistical correlation to average solvent accessibility of the residue blocks; single amino acid position variability results in no correlation, indicating the impact of stretch variability in chemical environment. Close to the C-terminal end the GSWM showed less descriptor-variability with increased average solvent accessibility (ASA that is also supported by conserved predicted secondary structure of 3' terminal RNA and visual evidence from 3D crystallographic structure. Conclusion The identified terminal segment, strongly conserved in both RNA and protein sequences, is especially significant as it is surface exposed and structural chemistry reveals the probable role of this stretch in

  6. [Social support and occupational stress relationship analysis of 1 413 train drivers in a railway bureau].

    Science.gov (United States)

    Gu, G Z; Yu, S F; Zhou, W H; Wu, H; Kang, L; Chen, R

    2017-02-06

    Objective: To investigate the social support status of train drivers. Methods: Using cluster sampling, a cross-sectional study was conducted in 1 413 male train drivers (including 301 passenger train drivers, 683 freight train drivers, 85 guest scheduling train drivers, 265 cargo adjustable drivers, and 79 high-speed train drivers) from a railway bureau depot. The survey included individual factors, social support, occupational stressors, strains, personalities, and coping strategy using occupational stress instruments and effort-reward imbalance questionnaire. We compared the difference in social support scores between different drivers, who were divided according to job type and age. Additionally, the correlation between social support score and job strain-related factors was analyzed. The influence of depressive symptoms and job satisfaction were analyzed using a non-conditional logistic multivariate model. Results: The overall average age P(50) (P(25),P(75)) of 1 413 train drivers was 33.92 (27.83,43.58) years. The overall average length of service 12.25 (5.25,22.75) years. A significant difference in social support scores was observed according to job type (H=23.23, Psocial support scores among different age groups were significantly different (H=6.64, P=0.036). The specific scores were ≤30 years (26 (22,31)), 30-40 years (27 (23,33)), and >40 years (27 (22,31)). Correlation analysis revealed that the social support score was negatively associated with job satisfaction (r=-0.43), reward (r=-0.22), working stability (r=-0.23), promotion opportunities (r=-0.12), positive affectivity (r=-0.31), esteem (r=-0.21), and self-esteem (r=-0.20) scores (Psocial support score was positively associated with sleep disorders (r=0.33), external effort (r=0.21), pay within (r=0.12), role conflict (r=0.20), conflict between groups (r=0.17), conflict in groups (r=0.06), responsibility for the others (r=0.06), responsibility for things (r=0.08), physiological needs (r=0

  7. Conservation of alternative polyadenylation patterns in mammalian genes

    Directory of Open Access Journals (Sweden)

    Benech Philippe

    2006-07-01

    Full Text Available Abstract Background Alternative polyadenylation is a widespread mechanism contributing to transcript diversity in eukaryotes. Over half of mammalian genes are alternatively polyadenylated. Our understanding of poly(A site evolution is limited by the lack of a reliable identification of conserved, equivalent poly(A sites among species. We introduce here a working definition of conserved poly(A sites as sites that are both (i properly aligned in human and mouse orthologous 3' untranslated regions (UTRs and (ii supported by EST or cDNA data in both species. Results We identified about 4800 such conserved poly(A sites covering one third of the orthologous gene set studied. Characteristics of conserved poly(A sites such as processing efficiency and tissue-specificity were analyzed. Conserved sites show a higher processing efficiency but no difference in tissular distribution when compared to non-conserved sites. In general, alternative poly(A sites are species-specific and involve minor, non-conserved sites that are unlikely to play essential roles. However, there are about 500 genes with conserved tandem poly(A sites. A significant fraction of these conserved tandems display a conserved arrangement of major/minor sites in their 3' UTR, suggesting that these alternative 3' ends may be under selection. Conclusion This analysis allows us to identify potential functional alternative poly(A sites and provides clues on the selective mechanisms at play in the appearance of multiple poly(A sites and their maintenance in the 3' UTRs of genes.

  8. Rooting the domain archaea by phylogenomic analysis supports the foundation of the new kingdom Proteoarchaeota.

    Science.gov (United States)

    Petitjean, Céline; Deschamps, Philippe; López-García, Purificación; Moreira, David

    2014-12-19

    The first 16S rRNA-based phylogenies of the Archaea showed a deep division between two groups, the kingdoms Euryarchaeota and Crenarchaeota. This bipartite classification has been challenged by the recent discovery of new deeply branching lineages (e.g., Thaumarchaeota, Aigarchaeota, Nanoarchaeota, Korarchaeota, Parvarchaeota, Aenigmarchaeota, Diapherotrites, and Nanohaloarchaeota) which have also been given the same taxonomic status of kingdoms. However, the phylogenetic position of some of these lineages is controversial. In addition, phylogenetic analyses of the Archaea have often been carried out without outgroup sequences, making it difficult to determine if these taxa actually define lineages at the same level as the Euryarchaeota and Crenarchaeota. We have addressed the question of the position of the root of the Archaea by reconstructing rooted archaeal phylogenetic trees using bacterial sequences as outgroup. These trees were based on commonly used conserved protein markers (32 ribosomal proteins) as well as on 38 new markers identified through phylogenomic analysis. We thus gathered a total of 70 conserved markers that we analyzed as a concatenated data set. In contrast with previous analyses, our trees consistently placed the root of the archaeal tree between the Euryarchaeota (including the Nanoarchaeota and other fast-evolving lineages) and the rest of archaeal species, which we propose to class within the new kingdom Proteoarchaeota. This implies the relegation of several groups previously classified as kingdoms (e.g., Crenarchaeota, Thaumarchaeota, Aigarchaeota, and Korarchaeota) to a lower taxonomic rank. In addition to taxonomic implications, this profound reorganization of the archaeal phylogeny has also consequences on our appraisal of the nature of the last archaeal ancestor, which most likely was a complex organism with a gene-rich genome.

  9. Conservation and Role of Electrostatics in Thymidylate Synthase.

    Science.gov (United States)

    Garg, Divita; Skouloubris, Stephane; Briffotaux, Julien; Myllykallio, Hannu; Wade, Rebecca C

    2015-11-27

    Conservation of function across families of orthologous enzymes is generally accompanied by conservation of their active site electrostatic potentials. To study the electrostatic conservation in the highly conserved essential enzyme, thymidylate synthase (TS), we conducted a systematic species-based comparison of the electrostatic potential in the vicinity of its active site. Whereas the electrostatics of the active site of TS are generally well conserved, the TSs from minimal organisms do not conform to the overall trend. Since the genomes of minimal organisms have a high thymidine content compared to other organisms, the observation of non-conserved electrostatics was surprising. Analysis of the symbiotic relationship between minimal organisms and their hosts, and the genetic completeness of the thymidine synthesis pathway suggested that TS from the minimal organism Wigglesworthia glossinidia (W.g.b.) must be active. Four residues in the vicinity of the active site of Escherichia coli TS were mutated individually and simultaneously to mimic the electrostatics of W.g.b TS. The measured activities of the E. coli TS mutants imply that conservation of electrostatics in the region of the active site is important for the activity of TS, and suggest that the W.g.b. TS has the minimal activity necessary to support replication of its reduced genome.

  10. Evaluating children's conservation biology learning at the zoo.

    Science.gov (United States)

    Jensen, Eric

    2014-08-01

    Millions of children visit zoos every year with parents or schools to encounter wildlife firsthand. Public conservation education is a requirement for membership in professional zoo associations. However, in recent years zoos have been criticized for failing to educate the public on conservation issues and related biological concepts, such as animal adaptation to habitats. I used matched pre- and postvisit mixed methods questionnaires to investigate the educational value of zoo visits for children aged 7-15 years. The questionnaires gathered qualitative data from these individuals, including zoo-related thoughts and an annotated drawing of a habitat. A content analysis of these qualitative data produced the quantitative data reported in this article. I evaluated the relative learning outcomes of educator-guided and unguided zoo visits at London Zoo, both in terms of learning about conservation biology (measured by annotated drawings) and changing attitudes toward wildlife conservation (measured using thought-listing data). Forty-one percent of educator-guided visits and 34% of unguided visits resulted in conservation biology-related learning. Negative changes in children's understanding of animals and their habitats were more prevalent in unguided zoo visits. Overall, my results show the potential educational value of visiting zoos for children. However, they also suggest that zoos' standard unguided interpretive materials are insufficient for achieving the best outcomes for visiting children. These results support a theoretical model of conservation biology learning that frames conservation educators as toolmakers who develop conceptual resources to enhance children's understanding of science.

  11. Comparative genomic analysis of a neurotoxigenic Clostridium species using partial genome sequence: Phylogenetic analysis of a few conserved proteins involved in cellular processes and metabolism.

    Science.gov (United States)

    Alam, Syed Imteyaz; Dixit, Aparna; Tomar, Arvind; Singh, Lokendra

    2010-04-01

    Clostridial organisms produce neurotoxins, which are generally regarded as the most potent toxic substances of biological origin and potential biological warfare agents. Clostridium tetani produces tetanus neurotoxin and is responsible for the fatal tetanus disease. In spite of the extensive immunization regimen, the disease is an important cause of death especially among neonates. Strains of C. tetani have not been genetically characterized except the complete genome sequencing of strain E88. The present study reports the genetic makeup and phylogenetic affiliations of an environmental strain of this bacterium with respect to C. tetani E88 and other clostridia. A shot gun library was constructed from the genomic DNA of C. tetani drde, isolated from decaying fish sample. Unique clones were sequenced and sequences compared with its closest relative C. tetani E88. A total of 275 clones were obtained and 32,457 bases of non-redundant sequence were generated. A total of 150 base changes were observed over the entire length of sequence obtained, including, additions, deletions and base substitutions. Of the total 120 ORFs detected, 48 exhibited closest similarity to E88 proteins of which three are hypothetical proteins. Eight of the ORFs exhibited similarity with hypothetical proteins from other organisms and 10 aligned with other proteins from unrelated organisms. There is an overall conservation of protein sequences among the two strains of C. tetani and. Selected ORFs involved in cellular processes and metabolism were subjected to phylogenetic analysis.

  12. Integrating clinicians, knowledge and data: expert-based cooperative analysis in healthcare decision support

    Directory of Open Access Journals (Sweden)

    García-Alonso Carlos

    2010-09-01

    Full Text Available Abstract Background Decision support in health systems is a highly difficult task, due to the inherent complexity of the process and structures involved. Method This paper introduces a new hybrid methodology Expert-based Cooperative Analysis (EbCA, which incorporates explicit prior expert knowledge in data analysis methods, and elicits implicit or tacit expert knowledge (IK to improve decision support in healthcare systems. EbCA has been applied to two different case studies, showing its usability and versatility: 1 Bench-marking of small mental health areas based on technical efficiency estimated by EbCA-Data Envelopment Analysis (EbCA-DEA, and 2 Case-mix of schizophrenia based on functional dependency using Clustering Based on Rules (ClBR. In both cases comparisons towards classical procedures using qualitative explicit prior knowledge were made. Bayesian predictive validity measures were used for comparison with expert panels results. Overall agreement was tested by Intraclass Correlation Coefficient in case "1" and kappa in both cases. Results EbCA is a new methodology composed by 6 steps:. 1 Data collection and data preparation; 2 acquisition of "Prior Expert Knowledge" (PEK and design of the "Prior Knowledge Base" (PKB; 3 PKB-guided analysis; 4 support-interpretation tools to evaluate results and detect inconsistencies (here Implicit Knowledg -IK- might be elicited; 5 incorporation of elicited IK in PKB and repeat till a satisfactory solution; 6 post-processing results for decision support. EbCA has been useful for incorporating PEK in two different analysis methods (DEA and Clustering, applied respectively to assess technical efficiency of small mental health areas and for case-mix of schizophrenia based on functional dependency. Differences in results obtained with classical approaches were mainly related to the IK which could be elicited by using EbCA and had major implications for the decision making in both cases. Discussion This

  13. Reporting Data with "Over-the-Counter" Data Analysis Supports Increases Educators' Analysis Accuracy

    Science.gov (United States)

    Rankin, Jenny Grant

    2013-01-01

    There is extensive research on the benefits of making data-informed decisions to improve learning, but these benefits rely on the data being effectively interpreted. Despite educators' above-average intellect and education levels, there is evidence many educators routinely misinterpret student data. Data analysis problems persist even at…

  14. Use of object-oriented classification and fragmentation analysis (1985-2008) to identify important areas for conservation in Cockpit Country, Jamaica.

    Science.gov (United States)

    Newman, Minke E; McLaren, Kurt P; Wilson, Byron S

    2011-01-01

    Forest fragmentation is one of the most important threats to global biodiversity, particularly in tropical developing countries. Identifying priority areas for conservation within these forests is essential to their effective management. However, this requires current, accurate environmental information that is often lacking in developing countries. The Cockpit Country, Jamaica, contains forests of international importance in terms of levels of endemism and overall diversity. These forests are under severe threat from the prospect of bauxite mining and other anthropogenic disturbances. In the absence of adequate, up-to-date ecological information, we used satellite remote sensing data and fragmentation analysis to identify interior forested areas that have experienced little or no change as priority conservation sites. We classified Landsat images from 1985, 1989, 1995, 2002, and 2008, using an object-oriented method, which allowed for the inclusion of roads. We conducted our fragmentation analysis using metrics to quantify changes in forest patch number, area, shape, and aggregation. Deforestation and fragmentation fluctuated within the 23-year period but were mostly confined to the periphery of the forest, close to roads and access trails. An area of core forest that remained intact over the period of study was identified within the largest forest patch, most of which was located within the boundaries of a forest reserve and included the last remaining patches of closed-broadleaf forest. These areas should be given highest priority for conservation, as they constitute important refuges for endemic or threatened biodiversity. Minimizing and controlling access will be important in maintaining this core.

  15. A compendium of energy conservation success stories

    Energy Technology Data Exchange (ETDEWEB)

    1988-09-01

    Three-quarters of DOE's Conservation R and D funds have been devoted to technology research and development: basic and applied research, exploratory R and D, engineering feasibility studies, pilot-scale prototype R and D, and technology demonstration. Non R and D projects have involved technology assessment program planning and analysis, model development, technology transfer and consumer information, health effects and safety research, and technical support for rule making. The success stories summarized in this compendium fall into three general categories: Completed Technology Success Stories, projects that have resulted in new energy-saving technologies that are presently being used in the private sector; Technical Success Stories, projects that have produced or disseminated important scientific/technical information likely to result in future energy savings; Program Success Stories, non-R and D activities that have resulted in nationally significant energy benefits. The Energy Conservation research and development program at DOE is managed by the Office of Conservation under the direction of the Deputy Assistant Secretary for Conservation. Three subordinate Program Offices correspond to the buildings, transportation, and industrial end-use sectors. A fourth subordinate Program Office/endash/Energy Utilization Research/endash/sponsors research and technical inventions for all end-use sectors.

  16. A Compendium of Energy Conservation Success Stories

    Science.gov (United States)

    1988-09-01

    Three-quarters of DOE's Conservation R and D funds have been devoted to technology research and development: basic and applied research, exploratory R and D, engineering feasibility studies, pilot-scale prototype R and D, and technology demonstration. Non R and D projects have involved technology assessment program planning and analysis, model development, technology transfer and consumer information, health effects and safety research, and technical support for rule making. The success stories summarized in this compendium fall into three general categories: Completed Technology Success Stories, projects that have resulted in new energy-saving technologies that are presently being used in the private sector; Technical Success Stories, projects that have produced or disseminated important scientific/technical information likely to result in future energy savings; Program Success Stories, non-R and D activities that have resulted in nationally significant energy benefits. The Energy Conservation research and development program at DOE is managed by the Office of Conservation under the direction of the Deputy Assistant Secretary for Conservation. Three subordinate Program Offices correspond to the buildings, transportation, and industrial end-use sectors. A fourth subordinate Program Office{endash}Energy Utilization Research{endash}sponsors research and technical inventions for all end-use sectors.

  17. Integrating automated structured analysis and design with Ada programming support environments

    Science.gov (United States)

    Hecht, Alan; Simmons, Andy

    1986-01-01

    Ada Programming Support Environments (APSE) include many powerful tools that address the implementation of Ada code. These tools do not address the entire software development process. Structured analysis is a methodology that addresses the creation of complete and accurate system specifications. Structured design takes a specification and derives a plan to decompose the system subcomponents, and provides heuristics to optimize the software design to minimize errors and maintenance. It can also produce the creation of useable modules. Studies have shown that most software errors result from poor system specifications, and that these errors also become more expensive to fix as the development process continues. Structured analysis and design help to uncover error in the early stages of development. The APSE tools help to insure that the code produced is correct, and aid in finding obscure coding errors. However, they do not have the capability to detect errors in specifications or to detect poor designs. An automated system for structured analysis and design TEAMWORK, which can be integrated with an APSE to support software systems development from specification through implementation is described. These tools completement each other to help developers improve quality and productivity, as well as to reduce development and maintenance costs. Complete system documentation and reusable code also resultss from the use of these tools. Integrating an APSE with automated tools for structured analysis and design provide capabilities and advantages beyond those realized with any of these systems used by themselves.

  18. Cave invertebrates in Espírito Santo state, Brazil: a primary analysis of endemism, threats and conservation priorities

    Directory of Open Access Journals (Sweden)

    Marconi Souza Silva

    2015-08-01

    Full Text Available The cave-dwelling invertebrates were studied according to their composition, biodiversity, distribution and threats in the Atlantic Forest Central Biodiversity Corridor, a priority area for conservation actions in Brazil. Twelve obligate cave species were found, plus 495 troglophile species. Araneae (103 spp., Coleoptera (61 spp., Diptera (56 spp. and Lepidoptera (38 spp. were the richest taxa. The richness was higher in the carbonate caves (63 spp., sd = 16.7 and the highest diversity in granitic caves (H´= 2.68, sd = 0.5. The spatial turnover was 63.45 and similarity less than 30%. The total richness was correlated with the linear extension of the caves (Rs = 0.757, p ≤ 0.05. Surrounding area deforestation and religious and tourist use were the main threats. Emergency attention is recommended regarding protective actions, management and conservation of caves of extremely high biological importance.

  19. COMPARATIVE STUDY ON THE CONSERVATION OF NUTRITIONAL ELEMENTS OF PEAS DURING STORAGE AND FOOD PROCESSING II. SENSORY ANALYSIS

    Directory of Open Access Journals (Sweden)

    CAMELIA VIZIREANU

    2014-05-01

    Full Text Available The Romanian market has been flooded with a wide range of frozen products or products preserved by sterilization. The quality of these products is reduced or altered by the storage modules, suppliers or customers, product type, and last but not least, by the quality of raw materials subjected to conservation. This study followed the evolution of the nutritional characteristics of three varieties of peas grown in the Galati region subjected to freezing or sterilization, and their behavior during food processing.

  20. Comparative developmental analysis of Drosophila and Tribolium reveals conserved and diverged roles of abrupt in insect wing evolution.

    Science.gov (United States)

    Ravisankar, Padmapriyadarshini; Lai, Yi-Ting; Sambrani, Nagraj; Tomoyasu, Yoshinori

    2016-01-15

    Morphological innovation is a fundamental process in evolution, yet its molecular basis is still elusive. Acquisition of elytra, highly modified beetle forewings, is an important innovation that has driven the successful radiation of beetles. Our RNAi screening for candidate genes has identified abrupt (ab) as a potential key player in elytron evolution. In this study, we performed a series of RNA interference (RNAi) experiments in both Tribolium and Drosophila to understand the contributions of ab to the evolution of beetle elytra. We found that (i) ab is essential for proper wing vein patterning both in Tribolium and Drosophila, (ii) ab has gained a novel function in determining the unique elytron shape in the beetle lineage, (iii) unlike Hippo and Insulin, other shape determining pathways, the shape determining function of ab is specific to the elytron and not required in the hindwing, (iv) ab has a previously undescribed role in the Notch signal-associated wing formation processes, which appears to be conserved between beetles and flies. These data suggest that ab has gained a new function during elytron evolution in beetles without compromising the conserved wing-related functions. Gaining a new function without losing evolutionarily conserved functions may be a key theme in the evolution of morphologically novel structures.

  1. Using Concept Mapping for Needs Analysis for a Social Support System in Learning Network

    Directory of Open Access Journals (Sweden)

    Danish Nadeem

    2011-01-01

    Full Text Available This paper describes the needs analysis of tool for connecting people in a Learning Network using Group Concept Mapping method. We conducted an empirical study to identify the most relevant features of such a tool. There were 11 experts from 7 different countries with technical and non-technical background who participated in the study. Each of the participants were invited by email and given a brief description about the scenario for the need of a tool in an online Learning Network to find people for help (social support system. This tool can be developed on mobile devices to search for peer learners. The participants generated 153 unique ideas about the need for social support system in Learning Network. These ideas were sorted and rated, and further analysis with Concept Mapping produced ten relevant clusters of interest. These clusters (concepts suggest the features which are relevant for a tool that would support learners in connecting with others in a Learning Network. The concept mapping methodology described in this paper has also been applied in other projects; one of them is about the “investigation of pedagogic areas in which mobile learning is an appropriate solution”. We intend to publish the work in the future publication.

  2. Reliability analysis of supporting pressure in tunnels based on three-dimensional failure mechanism

    Institute of Scientific and Technical Information of China (English)

    罗卫华; 李闻韬

    2016-01-01

    Based on nonlinear failure criterion, a three-dimensional failure mechanism of the possible collapse of deep tunnel is presented with limit analysis theory. Support pressure is taken into consideration in the virtual work equation performed under the upper bound theorem. It is necessary to point out that the properties of surrounding rock mass plays a vital role in the shape of collapsing rock mass. The first order reliability method and Monte Carlo simulation method are then employed to analyze the stability of presented mechanism. Different rock parameters are considered random variables to value the corresponding reliability index with an increasing applied support pressure. The reliability indexes calculated by two methods are in good agreement. Sensitivity analysis was performed and the influence of coefficient variation of rock parameters was discussed. It is shown that the tensile strength plays a much more important role in reliability index than dimensionless parameter, and that small changes occurring in the coefficient of variation would make great influence of reliability index. Thus, significant attention should be paid to the properties of surrounding rock mass and the applied support pressure to maintain the stability of tunnel can be determined for a given reliability index.

  3. Evolutionary conservation of alternative splicing in chicken

    Science.gov (United States)

    Katyal, S.; Gao, Z.; Liu, R.-Z.; Godbout, R.

    2013-01-01

    Alternative splicing represents a source of great diversity for regulating protein expression and function. It has been estimated that one-third to two-thirds of mammalian genes are alternatively spliced. With the sequencing of the chicken genome and analysis of transcripts expressed in chicken tissues, we are now in a position to address evolutionary conservation of alternative splicing events in chicken and mammals. Here, we compare chicken and mammalian transcript sequences of 41 alternatively-spliced genes and 50 frequently accessed genes. Our results support a high frequency of splicing events in chicken, similar to that observed in mammals. PMID:17675855

  4. Leadership: a new frontier in conservation science.

    Science.gov (United States)

    Manolis, Jim C; Chan, Kai M; Finkelstein, Myra E; Stephens, Scott; Nelson, Cara R; Grant, Jacqualine B; Dombeck, Michael P

    2009-08-01

    Leadership is a critical tool for expanding the influence of conservation science, but recent advances in leadership concepts and practice remain underutilized by conservation scientists. Furthermore, an explicit conceptual foundation and definition of leadership in conservation science are not available in the literature. Here we drew on our diverse leadership experiences, our reading of leadership literature, and discussions with selected conservation science leaders to define conservation-science leadership, summarize an exploratory set of leadership principles that are applicable to conservation science, and recommend actions to expand leadership capacity among conservation scientists and practitioners. We define 2 types of conservation-science leadership: shaping conservation science through path-breaking research, and advancing the integration of conservation science into policy, management, and society at large. We focused on the second, integrative type of leadership because we believe it presents the greatest opportunity for improving conservation effectiveness. We identified 8 leadership principles derived mainly from the "adaptive leadership" literature: recognize the social dimension of the problem; cycle frequently through action and reflection; get and maintain attention; combine strengths of multiple leaders; extend your reach through networks of relationships; strategically time your effort; nurture productive conflict; and cultivate diversity. Conservation scientists and practitioners should strive to develop themselves as leaders, and the Society for Conservation Biology, conservation organizations, and academia should support this effort through professional development, mentoring, teaching, and research.

  5. Use of stochastic multi-criteria decision analysis to support sustainable management of contaminated sediments.

    Science.gov (United States)

    Sparrevik, Magnus; Barton, David N; Bates, Mathew E; Linkov, Igor

    2012-02-01

    Sustainable management of contaminated sediments requires careful prioritization of available resources and focuses on efforts to optimize decisions that consider environmental, economic, and societal aspects simultaneously. This may be achieved by combining different analytical approaches such as risk analysis (RA), life cycle analysis (LCA), multicriteria decision analysis (MCDA), and economic valuation methods. We propose the use of stochastic MCDA based on outranking algorithms to implement integrative sustainability strategies for sediment management. In this paper we use the method to select the best sediment management alternatives for the dibenzo-p-dioxin and -furan (PCDD/F) contaminated Grenland fjord in Norway. In the analysis, the benefits of health risk reductions and socio-economic benefits from removing seafood health advisories are evaluated against the detriments of remedial costs and life cycle environmental impacts. A value-plural based weighing of criteria is compared to criteria weights mimicking traditional cost-effectiveness (CEA) and cost-benefit (CBA) analyses. Capping highly contaminated areas in the inner or outer fjord is identified as the most preferable remediation alternative under all criteria schemes and the results are confirmed by a probabilistic sensitivity analysis. The proposed methodology can serve as a flexible framework for future decision support and can be a step toward more sustainable decision making for contaminated sediment management. It may be applicable to the broader field of ecosystem restoration for trade-off analysis between ecosystem services and restoration costs.

  6. Project management in mine actions using Multi-Criteria-Analysis-based decision support system

    Directory of Open Access Journals (Sweden)

    Marko Mladineo

    2014-12-01

    Full Text Available In this paper, a Web-based Decision Support System (Web DSS, that supports humanitarian demining operations and restoration of mine-contaminated areas, is presented. The financial shortage usually triggers a need for priority setting in Project Management in Mine actions. As part of the FP7 Project TIRAMISU, a specialized Web DSS has been developed to achieve a fully transparent priority setting process. It allows stakeholders and donors to actively join the decision making process using a user-friendly and intuitive Web application. The main advantage of this Web DSS is its unique way of managing a mine action project using Multi-Criteria Analysis (MCA, namely the PROMETHEE method, in order to select priorities for demining actions. The developed Web DSS allows decision makers to use several predefined scenarios (different criteria weights or to develop their own, so it allows project managers to compare different demining possibilities with ease.

  7. DSC of human hair: a tool for claim support or incorrect data analysis?

    Science.gov (United States)

    Popescu, C; Gummer, C

    2016-10-01

    Differential scanning calorimetry (DSC) data are increasingly used to substantiate product claims of hair repair. Decreasing peak temperatures may indicate structural changes and chemical damage. Increasing the DSC, wet peak temperature is, therefore, often considered as proof of hair repair. A detailed understanding of the technique and hair structure indicates that this may not be a sound approach. Surveying the rich literature on the use of dynamic thermal analysis (DTA) and differential scanning calorimetry (DSC) for the analyses of human hair and the effect of cosmetic treatments, we underline some of the problems of hair structure and data interpretation. To overcome some of the difficulties of data interpretation, we advise that DSC acquired data should be supported by other techniques when used for claim substantiation. In this way, one can provide meaningful interpretation of the hair science and robust data for product claims support.

  8. A semi-analytical method for the analysis of pile-supported embankments

    Institute of Scientific and Technical Information of China (English)

    Wan-huan ZHOU; Ren-peng CHEN; Lin-shuang ZHAO; Zheng-zhong XU; Yun-min CHEN

    2012-01-01

    In this paper,a semi-analytical method for the analysis of pile-supported embankments is proposed.The mathematic model describes the cooperative behavior of pile,pile cap,foundation soil,and embankment fills.Based on Terzaghi's ID consolidation theory of saturated soil,the consolidation of foundation soil is calculated.The embankments with two different types of piles:floating piles and end-bearing piles are investigated and discussed.The results of axial force and skin friction distributions along the pile and the settlements of pile-supported embankments are presented.It is found that it takes a longer time for soil consolidation in the embankment with floating piles,compared with the case using end-bearing piles.The differential settlement between the pile and surrounding soil at the pile top is larger for the embankment with end-bearing piles,compared with the case of floating piles.

  9. Patient innovation: an analysis of patients' designs of digital technology support for everyday living with diabetes.

    Science.gov (United States)

    Kanstrup, Anne Marie; Bertelsen, Pernille; Nohr, Christian

    2015-01-01

    The aim of this paper is to identify characteristics of patients' contributions to innovation in health information technology (HIT). The paper outlines a theoretical definition of patient innovation and presents an analysis of four digital prototypes and 22 low-fidelity mock-ups designed by people affected by the chronic illness diabetes mellitus. Seventeen families (a total of 60 people) with one or more diabetic family members participated in design activities in a four-year research project focused on the design of digital support for everyday living with diabetes. Our analysis documented the originality of the analysed patient designs and identified three characteristics of patients' designs: socio-technical networks, objects with associated personal meanings and technology supporting the expression of identity. The paper concludes that patient innovation is defined by what is perceived as new by patients and/or others within the social system of adaptation. The analysed patient designs are original (as distinct from replications of or improvements on known products), and their characteristics are innovative contributions to the social system of everyday living with diabetes (i.e. they are perceived as new to the patients in the research study). The results of the analysis contribute to the credentials of patients as key actors in HIT innovation and call for participatory approaches in health informatics.

  10. Chemotherapy versus support cancer treatment in advanced gastric cancer: a meta-analysis

    Directory of Open Access Journals (Sweden)

    L. Casaretto

    2006-04-01

    Full Text Available The aim of the present study was to compare the efficacy of chemotherapy and support treatment in patients with advanced non-resectable gastric cancer in a systematic review and meta-analysis of randomized clinical trials that included a comparison of chemotherapy and support care treatment in patients diagnosed with gastric adenocarcinoma, regardless of their age, gender or place of treatment. The search strategy was based on the criteria of the Cochrane Base, using the following key words: 1 randomized clinical trials and antineoplastic combined therapy or gastrointestinal neoplasm, 2 stomach neoplasm and drug therapy, 3 clinical trial and multi-modality therapy, 4 stomach neoplasm and drug therapy or quality of life, 5 double-blind method or clinical trial. The search was carried out using the Cochrane, Medline and Lilacs databases. Five studies fulfilled the inclusion criteria, for a total of 390 participants, 208 (53% receiving chemotherapy, 182 (47% receiving support care treatment and 6 losses (1.6%. The 1-year survival rate was 8% for support care and 20% for chemotherapy (RR = 2.14, 95% CI = 1.00-4.57, P = 0.05; 30% of the patients in the chemotherapy group and 12% in the support care group attained a 6-month symptom-free period (RR = 2.33, 95% CI = 1.41-3.87, P < 0.01. Quality of life evaluated after 4 months was significantly better for the chemotherapy patients (34%; RR = 2.07, 95% CI = 1.31-3.28, P < 0.01 with tumor mass reduction (RR = 3.32, 95% CI = 0.77-14.24, P = 0.1. Chemotherapy increased the 1-year survival rate of the patients and provided a longer symptom-free period of 6 months and an improvement in quality of life.

  11. Identification of swamp deer (Cervus duvauceli duvauceli Cuvier) potential habitat in Jhilmil Jheel Conservation Reserve, Uttarakhand, India using multi-criteria analysis.

    Science.gov (United States)

    Nandy, S; Kushwaha, S P S; Gaur, Priyanka

    2012-04-01

    The present study aims to identify the potential habitat for swamp deer (Cervus duvauceli duvauceli Cuvier) in Jhilmil Jheel Conservation Reserve in the Uttarakhand province of India using multi-criteria analysis. The study area represents one of the last remnant habitats of the flagship species, the swamp deer in Uttarakhand, which is considered as vulnerable. The study showed that only 6.08% of the study area (225 km(2)) was highly suitable to suitable for the swamp deer. An area of 135.52 km(2) (60.23%) turned out to be moderately suitable. Within the officially designated Conservation Reserve (area 37.84 km(2)), 10.91% (4.13 km(2)) area was found highly suitable to suitable, while 74.19% (28.07 km(2)) happens to be moderately suitable. Only 14 km(2) area, which was found as suitable habitat for swamp deer falls short of the space required by a population of 134 animals. The problem could be mitigated if the agricultural land (2.47 km(2)) adjacent to the Jhilmil Jheel is brought under the Reserve management. This would provide additional area to meet the fodder requirement. The study brings out a particularly grim situation with limited options for conservation and management of the swamp deer in the Indo-Gangetic plains. It also emphasizes the role of geospatial techniques in quick appraisal of habitat attributes and identification of potential sites for protected areas.

  12. In Silico Analysis of Gene Expression Network Components Underlying Pigmentation Phenotypes in the Python Identified Evolutionarily Conserved Clusters of Transcription Factor Binding Sites

    Science.gov (United States)

    2016-01-01

    Color variation provides the opportunity to investigate the genetic basis of evolution and selection. Reptiles are less studied than mammals. Comparative genomics approaches allow for knowledge gained in one species to be leveraged for use in another species. We describe a comparative vertebrate analysis of conserved regulatory modules in pythons aimed at assessing bioinformatics evidence that transcription factors important in mammalian pigmentation phenotypes may also be important in python pigmentation phenotypes. We identified 23 python orthologs of mammalian genes associated with variation in coat color phenotypes for which we assessed the extent of pairwise protein sequence identity between pythons and mouse, dog, horse, cow, chicken, anole lizard, and garter snake. We next identified a set of melanocyte/pigment associated transcription factors (CREB, FOXD3, LEF-1, MITF, POU3F2, and USF-1) that exhibit relatively conserved sequence similarity within their DNA binding regions across species based on orthologous alignments across multiple species. Finally, we identified 27 evolutionarily conserved clusters of transcription factor binding sites within ~200-nucleotide intervals of the 1500-nucleotide upstream regions of AIM1, DCT, MC1R, MITF, MLANA, OA1, PMEL, RAB27A, and TYR from Python bivittatus. Our results provide insight into pigment phenotypes in pythons. PMID:27698666

  13. In Silico Analysis of Gene Expression Network Components Underlying Pigmentation Phenotypes in the Python Identified Evolutionarily Conserved Clusters of Transcription Factor Binding Sites

    Directory of Open Access Journals (Sweden)

    Kristopher J. L. Irizarry

    2016-01-01

    Full Text Available Color variation provides the opportunity to investigate the genetic basis of evolution and selection. Reptiles are less studied than mammals. Comparative genomics approaches allow for knowledge gained in one species to be leveraged for use in another species. We describe a comparative vertebrate analysis of conserved regulatory modules in pythons aimed at assessing bioinformatics evidence that transcription factors important in mammalian pigmentation phenotypes may also be important in python pigmentation phenotypes. We identified 23 python orthologs of mammalian genes associated with variation in coat color phenotypes for which we assessed the extent of pairwise protein sequence identity between pythons and mouse, dog, horse, cow, chicken, anole lizard, and garter snake. We next identified a set of melanocyte/pigment associated transcription factors (CREB, FOXD3, LEF-1, MITF, POU3F2, and USF-1 that exhibit relatively conserved sequence similarity within their DNA binding regions across species based on orthologous alignments across multiple species. Finally, we identified 27 evolutionarily conserved clusters of transcription factor binding sites within ~200-nucleotide intervals of the 1500-nucleotide upstream regions of AIM1, DCT, MC1R, MITF, MLANA, OA1, PMEL, RAB27A, and TYR from Python bivittatus. Our results provide insight into pigment phenotypes in pythons.

  14. Interacting Social and Environmental Predictors for the Spatial Distribution of Conservation Lands.

    Science.gov (United States)

    Baldwin, Robert F; Leonard, Paul B

    2015-01-01

    Conservation decisions should be evaluated for how they meet conservation goals at multiple spatial extents. Conservation easements are land use decisions resulting from a combination of social and environmental conditions. An emerging area of research is the evaluation of spatial distribution of easements and their spatial correlates. We tested the relative influence of interacting social and environmental variables on the spatial distribution of conservation easements by ownership category and conservation status. For the Appalachian region of the United States, an area with a long history of human occupation and complex land uses including public-private conservation, we found that settlement, economic, topographic, and environmental data associated with spatial distribution of easements (N = 4813). Compared to random locations, easements were more likely to be found in lower elevations, in areas of greater agricultural productivity, farther from public protected areas, and nearer other human features. Analysis of ownership and conservation status revealed sources of variation, with important differences between local and state government ownerships relative to non-governmental organizations (NGOs), and among U.S. Geological Survey (USGS) GAP program status levels. NGOs were more likely to have easements nearer protected areas, and higher conservation status, while local governments held easements closer to settlement, and on lands of greater agricultural potential. Logistic interactions revealed environmental variables having effects modified by social correlates, and the strongest predictors overall were social (distance to urban area, median household income, housing density, distance to land trust office). Spatial distribution of conservation lands may be affected by geographic area of influence of conservation groups, suggesting that multi-scale conservation planning strategies may be necessary to satisfy local and regional needs for reserve networks. Our

  15. Financial Support for Rural Cooperative Economy in China Based on Grey Correlation Analysis

    Institute of Scientific and Technical Information of China (English)

    Fuchang; XU; Chuandong; WANG

    2015-01-01

    This paper firstly analyzed current situations of financial support for rural cooperative economy in China and tested the correlation between rural finance and rural cooperative economy using the grey correlation analysis method. Results indicate that there is a close relationship between amount,structure and efficiency of rural finance and development of rural cooperative economy. The amount of rural finance has the largest promotion function to development of rural cooperative economy,the next is rural finance structure,and the least is efficiency of rural finance. Based on research conclusions,it came up with pertinent policy recommendations.

  16. Analysis of a Thrust Bearing with Flexible Pads and Flexible Supports

    DEFF Research Database (Denmark)

    Klit, Peder; Thomsen, Kim

    2007-01-01

    A theoretical analysis of a hydrodynamic thrust bearing is presented. The bearing investigated is used in an ndustrial product. The lubricant is water, but the results are valid also for other lubricants.At first the results from a 1-dimensional model for the fluid film forces and the associated ...... improvements in load carrying capacity is presented....... deformation of the bearing geometry is presented. This model enlightens the influence of pad flexibility and support location and flexibility. Subsequently results from a 2-dimensional model of the bearing is presented. The model is used to carry out an optimization of the bearing design, and the obtained...

  17. Section 2: Corrosion and failure analysis studies in support of the pulp and paper industry

    Energy Technology Data Exchange (ETDEWEB)

    Keiser, J.R.; Pawel, S.J.; Swindeman, R.W.; Longmire, H.F. [Oak Ridge National Lab., TN (United States)

    1997-04-01

    Technical support is being provided to various pulp and paper companies and related industries to help determine the cause of material degradation problems and to identify alternate materials to prevent such degradation. During the past year, examinations have included parts from several sootblowers, two failed economizer tubes, and inspection of a continuous digester. The results of the analyses and inspections were communicated to the plant operators, and, in some cases, recommendations were made. This article discusses examination of sootblower nozzles, which evidenced intergranular cracking. Analysis indicated the presence of chromium carbide precipitates along the grain boundaries, which can cause the sample to be sensitized to grain boundary attack.

  18. Strength Analysis and Process Simulation of Subway Contact Rail Support Bracket of Composite Materials

    Science.gov (United States)

    Fedulov, Boris N.; Safonov, Alexander A.; Sergeichev, Ivan V.; Ushakov, Andrey E.; Klenin, Yuri G.; Makarenko, Irina V.

    2016-10-01

    An application of composites for construction of subway brackets is a very effective approach to extend their lifetime. However, this approach involves the necessity to prevent process-induced distortions of the bracket due to thermal deformation and chemical shrinkage. At present study, a process simulation has been carried out to support the design of the production tooling. The simulation was based on the application of viscoelastic model for the resin. Simulation results were verified by comparison with results of manufacturing experiments. To optimize the bracket structure the strength analysis was carried out as well.

  19. Environmental control and life support systems analysis for a Space Station life sciences animal experiment

    Science.gov (United States)

    So, Kenneth T.; Hall, John B., Jr.; Thompson, Clifford D.

    1987-01-01

    NASA's Langley and Goddard facilities have evaluated the effects of animal science experiments on the Space Station's Environmental Control and Life Support System (ECLSS) by means of computer-aided analysis, assuming an animal colony consisting of 96 rodents and eight squirrel monkeys. Thirteen ECLSS options were established for the reclamation of metabolic oxygen and waste water. Minimum cost and weight impacts on the ECLSS are found to accrue to the system's operation in off-nominal mode, using electrochemical CO2 removal and a static feed electrolyzer for O2 generation.

  20. An Intelligent Tool to support Requirements Analysis and Conceptual Design of Database Design

    Institute of Scientific and Technical Information of China (English)

    王能斌; 刘海青

    1991-01-01

    As an application of artificial intelligence and expert system technology to database design,this paper presents an intelligent design tool NITDT,which comprises a requirements specification language NITSL,a knowledge representation language NITKL,and an inference engine with uncertainty reasoning capability.NITDT now covers the requirements analysis and conceptual design of database design.However,it is possible to be integrated with another database design tool,NITDBA,developed also at NIT to become an integrated design tool supporting the whole process of database design.

  1. Piping benchmark problems. Volume 1. Dynamic analysis uniform support motion response spectrum method

    Energy Technology Data Exchange (ETDEWEB)

    Bezler, P.; Hartzman, M.; Reich, M.

    1980-08-01

    A set of benchmark problems and solutions have been developed for verifying the adequacy of computer programs used for dynamic analysis and design of nuclear piping systems by the Response Spectrum Method. The problems range from simple to complex configurations which are assumed to experience linear elastic behavior. The dynamic loading is represented by uniform support motion, assumed to be induced by seismic excitation in three spatial directions. The solutions consist of frequencies, participation factors, nodal displacement components and internal force and moment components. Solutions to associated anchor point motion static problems are not included.

  2. The RST and PARP-like domain containing SRO protein family: analysis of protein structure, function and conservation in land plants

    Directory of Open Access Journals (Sweden)

    Salojärvi Jarkko

    2010-03-01

    Full Text Available Abstract Background The SROs (SIMILAR TO RCD-ONE are a group of plant-specific proteins which have important functions in stress adaptation and development. They contain the catalytic core of the poly(ADP-ribose polymerase (PARP domain and a C-terminal RST (RCD-SRO-TAF4 domain. In addition to these domains, several, but not all, SROs contain an N-terminal WWE domain. Results SROs are present in all analyzed land plants and sequence analysis differentiates between two structurally distinct groups; cryptogams and monocots possess only group I SROs whereas eudicots also contain group II. Group I SROs possess an N-terminal WWE domain (PS50918 but the WWE domain is lacking in group II SROs. Group I domain structure is widely represented in organisms as distant as humans (for example, HsPARP11. We propose a unified nomenclature for the SRO family. The SROs are able to interact with transcription factors through the C-terminal RST domain but themselves are generally not regulated at the transcriptional level. The most conserved feature of the SROs is the catalytic core of the poly(ADP-ribose polymerase (PS51059 domain. However, bioinformatic analysis of the SRO PARP domain fold-structure and biochemical assays of AtRCD1 suggested that SROs do not possess ADP-ribosyl transferase activity. Conclusions The SROs are a highly conserved family of plant specific proteins. Sequence analysis of the RST domain implicates a highly preserved protein structure in that region. This might have implications for functional conservation. We suggest that, despite the presence of the catalytic core of the PARP domain, the SROs do not possess ADP-ribosyl transferase activity. Nevertheless, the function of SROs is critical for plants and might be related to transcription factor regulation and complex formation.

  3. Reflection on the Status Quo of the Later Support to the Water Conservancy and Hydropower Resettlement in Yunnan Province%对云南水利水电移民后期扶持现状的思考

    Institute of Scientific and Technical Information of China (English)

    刘平荣; 赵小铭

    2015-01-01

    水利水电移民工作是库区各级政府工作的重要组成部分,做好移民搬迁安置、推进后期扶持发展,确保移民“搬得出、稳得住、逐步能致富”的目标,是摆在各级政府,特别是移民主管部门面前的一项重要任务,后期扶持工作要在拓宽扶持思路、开发移民区经济、探索发展致富路子、提升移民生存素质等方面开展相应工作。%The water conservancy and hydropower resettlement is an important part of the work for the governments at all levels in the reservoir area .It is an immediate task for the governments at all levels ,esp .the resettlement authori‐ties to do the work of migrants’ relocation and resettlement in order to carry out the later supportive work and ensure ma‐terializing the goal of migrants“relocating smoothly ,living stably and getting rich gradually” .The key to the later sup‐portive work is to start the corresponding work such as broadening the supporting ideas ,developing the immigrant area’ s economy ,exploring the approaches of migrants’ development and prosperity and enhancement of the living quality ,and so on .

  4. Internet-based support programs to alleviate psychosocial and physical symptoms in cancer patients: a literature analysis.

    Science.gov (United States)

    Bouma, Grietje; Admiraal, Jolien M; de Vries, Elisabeth G E; Schröder, Carolien P; Walenkamp, Annemiek M E; Reyners, Anna K L

    2015-07-01

    In this review the effect of internet-based support programs on psychosocial and physical symptoms resulting from cancer diagnosis and treatment is analyzed. Selection of studies was based on the following criteria: (non-)randomized controlled trials, performed in adult cancer patients, comparing quantitative psychosocial and/or physical outcomes of an internet-based support program with (a) comparison group(s). Literature search yielded 2032 studies of which 16 fulfilled the eligibility criteria. Three different internet-based support programs were identified: social support groups, online therapy for psychosocial/physical symptoms, and online systems integrating information, support, and coaching services. Outcomes improved by these programs in nine studies. Especially fatigue, social support, and distress improved, regardless of the program type. All online systems showed positive effects, mainly for social support and quality of life. This analysis indicates that internet-based support programs are effective in improving psychosocial and physical symptoms in cancer patients.

  5. Optimizing statistical classification accuracy of satellite remotely sensed imagery for supporting fast flood hydrological analysis

    Science.gov (United States)

    Alexakis, Dimitrios; Agapiou, Athos; Hadjimitsis, Diofantos; Retalis, Adrianos

    2012-06-01

    The aim of this study is to improve classification results of multispectral satellite imagery for supporting flood risk assessment analysis in a catchment area in Cyprus. For this purpose, precipitation and ground spectroradiometric data have been collected and analyzed with innovative statistical analysis methods. Samples of regolith and construction material were in situ collected and examined in the spectroscopy laboratory for their spectral response under consecutive different conditions of humidity. Moreover, reflectance values were extracted from the same targets using Landsat TM/ETM+ images, for drought and humid time periods, using archived meteorological data. The comparison of the results showed that spectral responses for all the specimens were less correlated in cases of substantial humidity, both in laboratory and satellite images. These results were validated with the application of different classification algorithms (ISODATA, maximum likelihood, object based, maximum entropy) to satellite images acquired during time period when precipitation phenomena had been recorded.

  6. Operational planning using Climatological Observations for Maritime Prediction and Analysis Support Service (COMPASS)

    Science.gov (United States)

    O'Connor, Alison; Kirtman, Benjamin; Harrison, Scott; Gorman, Joe

    2016-05-01

    The US Navy faces several limitations when planning operations in regard to forecasting environmental conditions. Currently, mission analysis and planning tools rely heavily on short-term (less than a week) forecasts or long-term statistical climate products. However, newly available data in the form of weather forecast ensembles provides dynamical and statistical extended-range predictions that can produce more accurate predictions if ensemble members can be combined correctly. Charles River Analytics is designing the Climatological Observations for Maritime Prediction and Analysis Support Service (COMPASS), which performs data fusion over extended-range multi-model ensembles, such as the North American Multi-Model Ensemble (NMME), to produce a unified forecast for several weeks to several seasons in the future. We evaluated thirty years of forecasts using machine learning to select predictions for an all-encompassing and superior forecast that can be used to inform the Navy's decision planning process.

  7. Text localization using standard deviation analysis of structure elements and support vector machines

    Directory of Open Access Journals (Sweden)

    Zagoris Konstantinos

    2011-01-01

    Full Text Available Abstract A text localization technique is required to successfully exploit document images such as technical articles and letters. The proposed method detects and extracts text areas from document images. Initially a connected components analysis technique detects blocks of foreground objects. Then, a descriptor that consists of a set of suitable document structure elements is extracted from the blocks. This is achieved by incorporating an algorithm called Standard Deviation Analysis of Structure Elements (SDASE which maximizes the separability between the blocks. Another feature of the SDASE is that its length adapts according to the requirements of the application. Finally, the descriptor of each block is used as input to a trained support vector machines that classify the block as text or not. The proposed technique is also capable of adjusting to the text structure of the documents. Experimental results on benchmarking databases demonstrate the effectiveness of the proposed method.

  8. Analysis and design of a web-based decision support system for choosing higher education studies

    Directory of Open Access Journals (Sweden)

    Kostoglou Vassilis

    2014-01-01

    Full Text Available The vocational orientation of the youngsters who are about to enter, study, or have recently graduated at higher education (HE institutions, and linking HE with labor market are two research areas which have not been investigated extensively in Balkan countries. Job (or occupational profiles, among other tools used in vocational orientation, provide standardized and digitized descriptions of different professions. This article focuses on the analysis and the design of a web-based decision support system (DSS to assist its users in getting thoroughly informed about HE studies in Greece, and eventually in choosing their vocational prospects. Apart from reviewing the related previous research work and relevant web-based systems, we present the main elements of the system’s analysis and its design, the extensions that could lead to even more powerful systems, and conclusions about the advantages, limitations and practical application of the DSS.

  9. Systems genomics analysis centered on epigenetic inheritance supports development of a unified theory of biology.

    Science.gov (United States)

    Sharma, Abhay

    2015-11-01

    New discoveries are increasingly demanding integration of epigenetics, molecular biology, genomic networks and physiology with evolution. This article provides a proof of concept for evolutionary transgenerational systems biology, proposed recently in the context of epigenetic inheritance in mammals. Gene set enrichment analysis of available genome-level mammalian data presented here seem consistent with the concept that: (1) heritable information about environmental effects in somatic cells is communicated to the germline by circulating microRNAs (miRNAs) or other RNAs released in physiological fluids; (2) epigenetic factors including miRNA-like small RNAs, DNA methylation and histone modifications are propagated across generations via gene networks; and (3) inherited epigenetic variations in the form of methylated cytosines are fixed in the population as thymines over the evolutionary time course. The analysis supports integration of physiology and epigenetics with inheritance and evolution. This may catalyze efforts to develop a unified theory of biology.

  10. A Stock Market Prediction Method Based on Support Vector Machines (SVM and Independent Component Analysis (ICA

    Directory of Open Access Journals (Sweden)

    Hakob GRIGORYAN

    2016-08-01

    Full Text Available The research presented in this work focuses on financial time series prediction problem. The integrated prediction model based on support vector machines (SVM with independent component analysis (ICA (called SVM-ICA is proposed for stock market prediction. The presented approach first uses ICA technique to extract important features from the research data, and then applies SVM technique to perform time series prediction. The results obtained from the SVM-ICA technique are compared with the results of SVM-based model without using any pre-processing step. In order to show the effectiveness of the proposed methodology, two different research data are used as illustrative examples. In experiments, the root mean square error (RMSE measure is used to evaluate the performance of proposed models. The comparative analysis leads to the conclusion that the proposed SVM-ICA model outperforms the simple SVM-based model in forecasting task of nonstationary time series.

  11. Understanding the Support Needs of People with Intellectual and Related Developmental Disabilities through Cluster Analysis and Factor Analysis of Statewide Data

    Science.gov (United States)

    Viriyangkura, Yuwadee

    2014-01-01

    Through a secondary analysis of statewide data from Colorado, people with intellectual and related developmental disabilities (ID/DD) were classified into five clusters based on their support needs characteristics using cluster analysis techniques. Prior latent factor models of support needs in the field of ID/DD were examined to investigate the…

  12. User`s manual of a support system for human reliability analysis

    Energy Technology Data Exchange (ETDEWEB)

    Yokobayashi, Masao [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Tamura, Kazuo

    1995-10-01

    Many kinds of human reliability analysis (HRA) methods have been developed. However, users are required to be skillful so as to use them, and also required complicated works such as drawing event tree (ET) and calculation of uncertainty bounds. Moreover, each method is not so complete that only one method of them is not enough to evaluate human reliability. Therefore, a personal computer (PC) based support system for HRA has been developed to execute HRA practically and efficiently. The system consists of two methods, namely, simple method and detailed one. The former uses ASEP that is a simplified THERP-technique, and combined method of OAT and HRA-ET/DeBDA is used for the latter. Users can select a suitable method for their purpose. Human error probability (HEP) data were collected and a database of them was built to use for the support system. This paper describes outline of the HRA methods, support functions and user`s guide of the system. (author).

  13. Comparison of analysis and vibration test results for a multiple supported piping system

    Energy Technology Data Exchange (ETDEWEB)

    Hsieh, B.J.; Kot, C.A.; Srinivasan, M.G.

    1989-01-01

    The behavior of a nuclear power plant piping system subjected to high level vibrational excitation is investigated experimentally and analytically. The objective is to evaluate the piping analysis method employed in the SMACS computer code. Experimental data are obtained from the Large Shaker Experiments (SHAG) conducted at the HDR Test Facility in Kahl/Main, FRG, in which the dynamic behavior of an in-plant piping system with various support configurations was investigated. Comparisons of calculational results with measured data indicate that the adequacy of the prediction depends primarily on the modeling of boundary conditions and dynamic supports. Treating the latter as rigid and using building motion as input, in general, results in under prediction of piping response. On the other hand when accelerations on the pipe side of the dynamic support attachment are used as input, piping response is highly overpredicted. Also modeling wall/floor component attachments as fixed usually leads to underprediction of amplitude as well as differences in the frequency content of response. 9 refs., 18 figs., 1 tab.

  14. Comprehensive analysis of the symmetries and conservation laws of the geodesic equations for a particular string inspired FRLW solution

    Science.gov (United States)

    Ahangari, Fatemeh

    2017-01-01

    Scalar-field cosmology can be regarded as one of the significant fields of research in recent years. This paper is dedicated to a thorough investigation of the symmetries and conservation laws of the geodesic equations associated to a specific exact cosmological solution of a scalar-field potential which was originally motivated by six-dimensional Einstein-Maxwell theory. The mentioned string inspired Friedmann-Robertson-Lamai ^tre-Walker (FRLW) solution is one of the noteworthy solutions of Einstein field equations. For this purpose, first of all the Christoffel symbols and the corresponding system of geodesic equations are computed and then the associated Lie symmetries are totally analyzed. Moreover, the algebraic structure of the Lie algebra of local symmetries is briefly investigated and a complete classification of the symmetry subalgebras is presented. Besides by applying the resulted symmetry operators the invariant solutions of the system of geodesic equations are discussed. In addition, the Noether symmetries and the Killing vector fields of the geodesic Lagrangian are determined and the corresponding optimal system of one-dimensional subalgebras is constructed. Mainly, an entire set of local conservation laws is computed for our analyzed scalar-field cosmological solution. For this purpose, two distinct procedures are applied: the celebrated Noether's theorem and the direct method which is fundamentally based on a systematic application of Euler differential operators which annihilate any divergence expression identically.

  15. Genomic analysis of freshwater cyanophage Pf-WMP3 Infecting cyanobacterium Phormidium foveolarum: the conserved elements for a phage.

    Science.gov (United States)

    Liu, Xinyao; Kong, Shuanglei; Shi, Miao; Fu, Liwen; Gao, Yin; An, Chengcai

    2008-11-01

    Cyanophages are ecologically abundant, genetically diverse in aquatic environments, and affect the population and evolutionary trajectories of their hosts. After reporting the cyanophage Pf-WMP4 genome (Liu et al. in Virology 366:28-39, 2007), we hereby present a related cyanophage, Pf-WMP3, which also infects the freshwater cyanobacterium Phormidium foveolarum. The Pf-WMP3 genome contains 43,249 bp with 234 bp direct terminal repeats. The overall genome organization and core genes of the two phages are comparable to those of the T7 supergroup phages. Compared with Pf-WMP4, cyanophage Pf-WMP3 has diverged extensively at the DNA level; however, they are closely related at the protein level and genome architecture. The left arm genes for the two phages, which mainly encode the DNA replication machinery, are not conserved in the gene order. Whereas the right arm genes of the two phages coding for structural proteins show high similarity in amino acid sequences and modular architecture, indicating that they have retained similar development strategies. The differences in similarity levels between the left and right arm genes suggest that the structural genes are the most conserved elements for a phage.

  16. RVA. 3-D Visualization and Analysis Software to Support Management of Oil and Gas Resources

    Energy Technology Data Exchange (ETDEWEB)

    Keefer, Donald A. [Univ. of Illinois, Champaign, IL (United States); Shaffer, Eric G. [Univ. of Illinois, Champaign, IL (United States); Storsved, Brynne [Univ. of Illinois, Champaign, IL (United States); Vanmoer, Mark [Univ. of Illinois, Champaign, IL (United States); Angrave, Lawrence [Univ. of Illinois, Champaign, IL (United States); Damico, James R. [Univ. of Illinois, Champaign, IL (United States); Grigsby, Nathan [Univ. of Illinois, Champaign, IL (United States)

    2015-12-01

    A free software application, RVA, has been developed as a plugin to the US DOE-funded ParaView visualization package, to provide support in the visualization and analysis of complex reservoirs being managed using multi-fluid EOR techniques. RVA, for Reservoir Visualization and Analysis, was developed as an open-source plugin to the 64 bit Windows version of ParaView 3.14. RVA was developed at the University of Illinois at Urbana-Champaign, with contributions from the Illinois State Geological Survey, Department of Computer Science and National Center for Supercomputing Applications. RVA was designed to utilize and enhance the state-of-the-art visualization capabilities within ParaView, readily allowing joint visualization of geologic framework and reservoir fluid simulation model results. Particular emphasis was placed on enabling visualization and analysis of simulation results highlighting multiple fluid phases, multiple properties for each fluid phase (including flow lines), multiple geologic models and multiple time steps. Additional advanced functionality was provided through the development of custom code to implement data mining capabilities. The built-in functionality of ParaView provides the capacity to process and visualize data sets ranging from small models on local desktop systems to extremely large models created and stored on remote supercomputers. The RVA plugin that we developed and the associated User Manual provide improved functionality through new software tools, and instruction in the use of ParaView-RVA, targeted to petroleum engineers and geologists in industry and research. The RVA web site (http://rva.cs.illinois.edu) provides an overview of functions, and the development web site (https://github.com/shaffer1/RVA) provides ready access to the source code, compiled binaries, user manual, and a suite of demonstration data sets. Key functionality has been included to support a range of reservoirs visualization and analysis needs, including

  17. The NOAA Local Climate Analysis Tool - An Application in Support of a Weather Ready Nation

    Science.gov (United States)

    Timofeyeva, M. M.; Horsfall, F. M.

    2012-12-01

    Citizens across the U.S., including decision makers from the local to the national level, have a multitude of questions about climate, such as the current state and how that state fits into the historical context, and more importantly, how climate will impact them, especially with regard to linkages to extreme weather events. Developing answers to these types of questions for locations has typically required extensive work to gather data, conduct analyses, and generate relevant explanations and graphics. Too frequently providers don't have ready access to or knowledge of reliable, trusted data sets, nor sound, scientifically accepted analysis techniques such that they can provide a rapid response to queries they receive. In order to support National Weather Service (NWS) local office forecasters with information they need to deliver timely responses to climate-related questions from their customers, we have developed the Local Climate Analysis Tool (LCAT). LCAT uses the principles of artificial intelligence to respond to queries, in particular, through use of machine technology that responds intelligently to input from users. A user translates customer questions into primary variables and issues and LCAT pulls the most relevant data and analysis techniques to provide information back to the user, who in turn responds to their customer. Most responses take on the order of 10 seconds, which includes providing statistics, graphical displays of information, translations for users, metadata, and a summary of the user request to LCAT. Applications in Phase I of LCAT, which is targeted for the NWS field offices, include Climate Change Impacts, Climate Variability Impacts, Drought Analysis and Impacts, Water Resources Applications, Attribution of Extreme Events, and analysis techniques such as time series analysis, trend analysis, compositing, and correlation and regression techniques. Data accessed by LCAT are homogenized historical COOP and Climate Prediction Center

  18. Multi-Season Regional Analysis of Multi-Species Occupancy: Implications for Bird Conservation in Agricultural Lands in East-Central Argentina.

    Science.gov (United States)

    Goijman, Andrea Paula; Conroy, Michael J; Bernardos, Jaime Nicolás; Zaccagnini, María Elena

    2015-01-01

    Rapid expansion and intensification of agriculture create challenges for the conservation of biodiversity and associated ecosystem services. In Argentina, the total row crop planted area has increased in recent decades with the expansion of soybean cultivation, homogenizing the landscape. In 2003 we started the first long-term, large-scale bird monitoring program in agroecosystems of central Argentina, in portions of the Pampas and Espinal ecoregions. Using data from this program, we evaluated the effect of land use and cover extent on birds between 2003-2012, accounting for imperfect detection probabilities using a Bayesian hierarchical, multi-species and multi-season occupancy model. We tested predictions that species diversity is positively related to habitat heterogeneity, which in intensified agroecosystems is thought to be mediated by food availability; thus the extent of land use and cover is predicted to affect foraging guilds differently. We also infer about ecosystem services provisioning and inform management recommendations for conservation of birds. Overall our results support the predictions. Although many species within each guild responded differently to land use and native forest cover, we identified generalities for most trophic guilds. For example, granivorous gleaners, ground insectivores and omnivores responded negatively to high proportions of soybean, while insectivore gleaners and aerial foragers seemed more tolerant. Habitat heterogeneity would likely benefit most species in an intensified agroecosystem, and can be achieved with a diversity of crops, pastures, and natural areas within the landscape. Although most studied species are insectivores, potentially beneficial for pest control, some guilds such as ground insectivores are poorly represented, suggesting that agricultural intensification reduces ecological functions, which may be recovered through management. Continuation of the bird monitoring program will allow us to continue to

  19. Multi-Season Regional Analysis of Multi-Species Occupancy: Implications for Bird Conservation in Agricultural Lands in East-Central Argentina.

    Directory of Open Access Journals (Sweden)

    Andrea Paula Goijman

    Full Text Available Rapid expansion and intensification of agriculture create challenges for the conservation of biodiversity and associated ecosystem services. In Argentina, the total row crop planted area has increased in recent decades with the expansion of soybean cultivation, homogenizing the landscape. In 2003 we started the first long-term, large-scale bird monitoring program in agroecosystems of central Argentina, in portions of the Pampas and Espinal ecoregions. Using data from this program, we evaluated the effect of land use and cover extent on birds between 2003-2012, accounting for imperfect detection probabilities using a Bayesian hierarchical, multi-species and multi-season occupancy model. We tested predictions that species diversity is positively related to habitat heterogeneity, which in intensified agroecosystems is thought to be mediated by food availability; thus the extent of land use and cover is predicted to affect foraging guilds differently. We also infer about ecosystem services provisioning and inform management recommendations for conservation of birds. Overall our results support the predictions. Although many species within each guild responded differently to land use and native forest cover, we identified generalities for most trophic guilds. For example, granivorous gleaners, ground insectivores and omnivores responded negatively to high proportions of soybean, while insectivore gleaners and aerial foragers seemed more tolerant. Habitat heterogeneity would likely benefit most species in an intensified agroecosystem, and can be achieved with a diversity of crops, pastures, and natural areas within the landscape. Although most studied species are insectivores, potentially beneficial for pest control, some guilds such as ground insectivores are poorly represented, suggesting that agricultural intensification reduces ecological functions, which may be recovered through management. Continuation of the bird monitoring program will allow

  20. Use of Human Modeling Simulation Software in the Task Analysis of the Environmental Control and Life Support System Component Installation Procedures

    Science.gov (United States)

    Estes, Samantha; Parker, Nelson C. (Technical Monitor)

    2001-01-01

    Virtual reality and simulation applications are becoming widespread in human task analysis. These programs have many benefits for the Human Factors Engineering field. Not only do creating and using virtual environments for human engineering analyses save money and time, this approach also promotes user experimentation and provides increased quality of analyses. This paper explains the human engineering task analysis performed on the Environmental Control and Life Support System (ECLSS) space station rack and its Distillation Assembly (DA) subsystem using EAI's human modeling simulation software, Jack. When installed on the International Space Station (ISS), ECLSS will provide the life and environment support needed to adequately sustain crew life. The DA is an Orbital Replaceable Unit (ORU) that provides means of wastewater (primarily urine from flight crew and experimental animals) reclamation. Jack was used to create a model of the weightless environment of the ISS Node 3, where the ECLSS is housed. Computer aided drawings of the ECLSS rack and DA system were also brought into the environment. Anthropometric models of a 95th percentile male and 5th percentile female were used to examine the human interfaces encountered during various ECLSS and DA tasks. The results of the task analyses were used in suggesting modifications to hardware and crew task procedures to improve accessibility, conserve crew time, and add convenience for the crew. This paper will address some of those suggested modifications and the method of presenting final analyses for requirements verification.