WorldWideScience

Sample records for analysis providing context

  1. ContextProvider: Context awareness for medical monitoring applications.

    Science.gov (United States)

    Mitchell, Michael; Meyers, Christopher; Wang, An-I Andy; Tyson, Gary

    2011-01-01

    Smartphones are sensor-rich and Internet-enabled. With their on-board sensors, web services, social media, and external biosensors, smartphones can provide contextual information about the device, user, and environment, thereby enabling the creation of rich, biologically driven applications. We introduce ContextProvider, a framework that offers a unified, query-able interface to contextual data on the device. Unlike other context-based frameworks, ContextProvider offers interactive user feedback, self-adaptive sensor polling, and minimal reliance on third-party infrastructure. ContextProvider also allows for rapid development of new context and bio-aware applications. Evaluation of ContextProvider shows the incorporation of an additional monitoring sensor into the framework with fewer than 100 lines of Java code. With adaptive sensor monitoring, power consumption per sensor can be reduced down to 1% overhead. Finally, through the use of context, accuracy of data interpretation can be improved by up to 80%.

  2. Preventing Adolescent Risk Behavior in the Rural Context: An Integrative Analysis of Adolescent, Parent, and Provider Perspectives

    Science.gov (United States)

    Rishel, Carrie W.; Cottrell, Lesley; Kingery, Tricia

    2012-01-01

    Adolescent risk behavior remains prevalent and contributes to numerous social problems and growing health care costs. Contrary to popular perception, adolescents in rural areas engage in risky behaviors at least as much as youth from urban or suburban settings. Little research, however, focuses on risk behavior prevention in the rural context.…

  3. Enhancing Context Analysis with Intelligence in Providing e-Health Services: Less Infrastructure Dependency in Supporting Cardio-Vascular Patients

    OpenAIRE

    Verbraeck, A.; Widya, I.A.; Shishkov, Boris; Cordeiro, J.; Ranchordas, A.

    2009-01-01

    In Europe, we observe an increasing number of people with health problems, who could theoretically receive care outside of a hospital when their condition could be properly monitored. Not being able to provide this monitoring leads to an increasing pressure on an already overcrowded hospital system and increased costs. Ubiquitous technology on top of a high-quality IT infra-structure has already proven to be able to provide partial solutions. However, such infrastructure is not available thro...

  4. Enhancing Context Analysis with Intelligence in Providing e-Health Services: Less Infrastructure Dependency in Supporting Cardio-Vascular Patients

    NARCIS (Netherlands)

    Verbraeck, A.; Widya, I.A.; Shishkov, Boris; Cordeiro, J.; Ranchordas, A.

    2009-01-01

    In Europe, we observe an increasing number of people with health problems, who could theoretically receive care outside of a hospital when their condition could be properly monitored. Not being able to provide this monitoring leads to an increasing pressure on an already overcrowded hospital system

  5. Product Context Analysis with Twitter Data

    OpenAIRE

    Sun, Tao

    2016-01-01

    Context. For the product manager, the product context analysis, which aims to align their products to the market needs, is very important. By understanding the market needs, the product manager knows the product context information about the environment the products conceived and the business the products take place. The product context analysis using the product context information helps the product manager find the accurate position of his/her products and support the decision-making of the...

  6. Preliminary Context Analysis of Community Informatics Social ...

    African Journals Online (AJOL)

    Preliminary context analysis is always part of the feasibility study phase in the development of information system for Community Development (CD) purposes. In this paper, a context model and a preliminary context analysis are presented for Social Network Web Application (SNWA) for CD in the Niger Delta region of ...

  7. CONTEXT BASED FOOD IMAGE ANALYSIS

    OpenAIRE

    He, Ye; Xu, Chang; Khanna, Nitin; Boushey, Carol J.; Delp, Edward J.

    2013-01-01

    We are developing a dietary assessment system that records daily food intake through the use of food images. Recognizing food in an image is difficult due to large visual variance with respect to eating or preparation conditions. This task becomes even more challenging when different foods have similar visual appearance. In this paper we propose to incorporate two types of contextual dietary information, food co-occurrence patterns and personalized learning models, in food image analysis to r...

  8. Identifiable Data Files - Medicare Provider Analysis and ...

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Medicare Provider Analysis and Review (MEDPAR) File contains data from claims for services provided to beneficiaries admitted to Medicare certified inpatient...

  9. Value chain analysis in quality management context

    Directory of Open Access Journals (Sweden)

    Popescu, M.

    2011-01-01

    Full Text Available Based on the description of value chain analysis, which is a strategic management tool attributed to Michel Porter, the paper aims to demonstrate that quality management applies this method, under specific forms. The paper's specific objectives are: to redefine the functions of value chain analysis in the context of quality management; to clarify the significance and the possibilities of measuring the value added; to present management tools and techniques needed to control and systematically improve performance. Research methodology is based on examples, previous studies and a case study that reveals the diversity of indicators for measuring the value added and analysis tools used in quality management.

  10. Teaching sterile skills in anesthesia : Is providing context helpful for robust skill acquisition?

    NARCIS (Netherlands)

    Cnossen, Fokeltje; Paul, Katja; Lettinga, Roelof; Wietasch, Johann

    2015-01-01

    Epidural anesthesia is an invasive medical procedure for pain relief. However, current teaching methods are not sufficient for acquiring proper aseptic technique in this procedure (Friedman et al., 2008). In the present study we examined whether a context-providing method, previously successfully

  11. Sensitivity analysis in a structural reliability context

    International Nuclear Information System (INIS)

    Lemaitre, Paul

    2014-01-01

    This thesis' subject is sensitivity analysis in a structural reliability context. The general framework is the study of a deterministic numerical model that allows to reproduce a complex physical phenomenon. The aim of a reliability study is to estimate the failure probability of the system from the numerical model and the uncertainties of the inputs. In this context, the quantification of the impact of the uncertainty of each input parameter on the output might be of interest. This step is called sensitivity analysis. Many scientific works deal with this topic but not in the reliability scope. This thesis' aim is to test existing sensitivity analysis methods, and to propose more efficient original methods. A bibliographical step on sensitivity analysis on one hand and on the estimation of small failure probabilities on the other hand is first proposed. This step raises the need to develop appropriate techniques. Two variables ranking methods are then explored. The first one proposes to make use of binary classifiers (random forests). The second one measures the departure, at each step of a subset method, between each input original density and the density given the subset reached. A more general and original methodology reflecting the impact of the input density modification on the failure probability is then explored. The proposed methods are then applied on the CWNR case, which motivates this thesis. (author)

  12. Information logistics usage necessity within the context of utility providing of tourist product

    OpenAIRE

    Самойленко, Катерина Володимирівна

    2014-01-01

    The features of formation and utility providing of the tourist product are discussed in the article. The main aim of investigation is the objective determination of consumer characteristics (assembly of characteristics) that should be inherent in the tourism product on the perception and evaluation of consumers. It is determined that the creation and provision of utility providing of tourist product is a complex and multifactorial. Product usefulness problem is considered in the context of co...

  13. Population Analysis: Communicating About Anthropometry in Context

    Science.gov (United States)

    Thaxton, Sherry; Rajulu, Sudhakar

    2009-01-01

    This slide presentation reviews the importance of communications about anthropometry and population analysis in particular for the design of aerospace systems. The difficulty of providing anthropometric accomodation an entire range of the population is reviewed, and the importance of communication of the issues with human system integration is emphasized, and the analysis of population as it applies to existing human factors methodologies is a novel way to assist with the communication. The issues of space suit design and anthropometry is reviewed as an example.

  14. Context analysis : sky, water and motion

    NARCIS (Netherlands)

    Javanbakhti, S.; Zinger, S.; With, de P.H.N.

    2011-01-01

    Interpreting the events present in the video is a complex task, and the same gesture or motion can be understood in several ways depending on the context of the event and/or the scene. Therefore the context of the scene can contribute to the semantic understanding of the video. In this paper, we

  15. The Innovative Activity of Enterprises in the Context of Providing Information Security

    Directory of Open Access Journals (Sweden)

    Sazonets Olga M.

    2015-03-01

    Full Text Available The aim of the article is to study the peculiarities of the innovative activity in the context of providing the enterprise information security. By analyzing, systematizing and summarizing the scientific works of many scientists the essence of the concept of «information security» has been considered and components of the innovation development process from the standpoint of providing information security have been identified. The article discusses issues of providing information security on the basis of introducing innovations, which will allow achieving a state in which there would be realized a sustainable, protected from threats, development of the enterprise. It has been proved that the formation of the innovative enterprise policy should include measures to ensure information security. As a result of the study the types of threats to the enterprise information security have been identified. It has been determined that the innovation process in the field of information security is provided by means of research, administrative, industrial, technological and commercial activities leading to the emergence and commercialization of innovations. The prospect for further research in this area is determining a system of indicators for forecasting the integral innovation indicator of economic information security. The system of indicators for diagnostics of the enterprise information security level enables monitoring the indicators of the state of the enterprise innovation and information activity in order to prevent the emergence of threats.

  16. Understanding context in knowledge translation: a concept analysis study protocol.

    Science.gov (United States)

    Squires, Janet E; Graham, Ian D; Hutchinson, Alison M; Linklater, Stefanie; Brehaut, Jamie C; Curran, Janet; Ivers, Noah; Lavis, John N; Michie, Susan; Sales, Anne E; Fiander, Michelle; Fenton, Shannon; Noseworthy, Thomas; Vine, Jocelyn; Grimshaw, Jeremy M

    2015-05-01

    To conduct a concept analysis of clinical practice contexts (work environments) that facilitate or militate against the uptake of research evidence by healthcare professionals in clinical practice. This will involve developing a clear definition of context by describing its features, domains and defining characteristics. The context where clinical care is delivered influences that care. While research shows that context is important to knowledge translation (implementation), we lack conceptual clarity on what is context, which contextual factors probably modify the effect of knowledge translation interventions (and hence should be considered when designing interventions) and which contextual factors themselves could be targeted as part of a knowledge translation intervention (context modification). Concept analysis. The Walker and Avant concept analysis method, comprised of eight systematic steps, will be used: (1) concept selection; (2) determination of aims; (3) identification of uses of context; (4) determination of defining attributes of context; (5) identification/construction of a model case of context; (6) identification/construction of additional cases of context; (7) identification/construction of antecedents and consequences of context; and (8) definition of empirical referents of context. This study is funded by the Canadian Institutes of Health Research (January 2014). This study will result in a much needed framework of context for knowledge translation, which identifies specific elements that, if assessed and used to tailor knowledge translation activities, will result in increased research use by nurses and other healthcare professionals in clinical practice, ultimately leading to better patient care. © 2014 John Wiley & Sons Ltd.

  17. Analysis and modeling of "focus" in context

    DEFF Research Database (Denmark)

    Hovy, Dirk; Anumanchipalli, Gopala; Parlikar, Alok

    2013-01-01

    This paper uses a crowd-sourced definition of a speech phenomenon we have called focus. Given sentences, text and speech, in isolation and in context, we asked annotators to identify what we term the focus word. We present their consistency in identifying the focused word, when presented with text...... or speech stimuli. We then build models to show how well we predict that focus word from lexical (and higher) level features. Also, using spectral and prosodic information, we show the differences in these focus words when spoken with and without context. Finally, we show how we can improve speech synthesis...

  18. Medicare Provider Analysis and Review (MEDPAR)

    Data.gov (United States)

    U.S. Department of Health & Human Services — MEDPAR files contain information on Medicare beneficiaries using hospital inpatient services. The data is provided by the state and the Diagnosis Related Groups...

  19. Providing Context for Complexity: Using Infographics and Conceptual Models to Teach Global Change Processes

    Science.gov (United States)

    Bean, J. R.; White, L. D.

    2015-12-01

    Understanding modern and historical global changes requires interdisciplinary knowledge of the physical and life sciences. The Understanding Global Change website from the UC Museum of Paleontology will use a focal infographic that unifies diverse content often taught in separate K-12 science units. This visualization tool provides scientists with a structure for presenting research within the broad context of global change, and supports educators with a framework for teaching and assessing student understanding of complex global change processes. This new approach to teaching the science of global change is currently being piloted and refined based on feedback from educators and scientists in anticipation of a 2016 website launch. Global change concepts are categorized within the infographic as causes of global change (e.g., burning of fossil fuels, volcanism), ongoing Earth system processes (e.g., ocean circulation, the greenhouse effect), and the changes scientists measure in Earth's physical and biological systems (e.g., temperature, extinctions/radiations). The infographic will appear on all website content pages and provides a template for the creation of flowcharts, which are conceptual models that allow teachers and students to visualize the interdependencies and feedbacks among processes in the atmosphere, hydrosphere, biosphere, and geosphere. The development of this resource is timely given that the newly adopted Next Generation Science Standards emphasize cross-cutting concepts, including model building, and Earth system science. Flowchart activities will be available on the website to scaffold inquiry-based lessons, determine student preconceptions, and assess student content knowledge. The infographic has already served as a learning and evaluation tool during professional development workshops at UC Berkeley, Stanford University, and the Smithsonian National Museum of Natural History. At these workshops, scientists and educators used the infographic

  20. Human Behavior Analysis by Means of Multimodal Context Mining

    Directory of Open Access Journals (Sweden)

    Oresti Banos

    2016-08-01

    Full Text Available There is sufficient evidence proving the impact that negative lifestyle choices have on people’s health and wellness. Changing unhealthy behaviours requires raising people’s self-awareness and also providing healthcare experts with a thorough and continuous description of the user’s conduct. Several monitoring techniques have been proposed in the past to track users’ behaviour; however, these approaches are either subjective and prone to misreporting, such as questionnaires, or only focus on a specific component of context, such as activity counters. This work presents an innovative multimodal context mining framework to inspect and infer human behaviour in a more holistic fashion. The proposed approach extends beyond the state-of-the-art, since it not only explores a sole type of context, but also combines diverse levels of context in an integral manner. Namely, low-level contexts, including activities, emotions and locations, are identified from heterogeneous sensory data through machine learning techniques. Low-level contexts are combined using ontological mechanisms to derive a more abstract representation of the user’s context, here referred to as high-level context. An initial implementation of the proposed framework supporting real-time context identification is also presented. The developed system is evaluated for various realistic scenarios making use of a novel multimodal context open dataset and data on-the-go, demonstrating prominent context-aware capabilities at both low and high levels.

  1. Needs Analysis and English Teaching in Professional Contexts

    Directory of Open Access Journals (Sweden)

    Orlando Vian Jr.

    2011-07-01

    Full Text Available Based on the concept of needs analysis as proposed by Hutchinson and Waters (1987, this article discusses some aspects of English teaching in professional contexts in Brazil. We start with a brief historical view of needs analysis in order to discuss its application to teaching English for specific business purposes in professional contexts and its role for the instructor teaching in-company classes. We also aim to discuss the importance of needs analysis and its relation to the business area, as well as other features related to teaching in these contexts and its relevance to the professionals involved with business English teaching.

  2. This Month in Astronomical History: Providing Context for the Advancement of Astronomy

    Science.gov (United States)

    Wilson, Teresa

    2018-01-01

    This Month in Astronomical History is a short (~500 word) illustrated column hosted on the AAS website (https://had.aas.org/resources/astro-history). Its mission is to highlight people and events that have shaped the development of astronomy to convey a historical context to current researchers, to provide a resource for education and public outreach programs seeking to incorporate a historical perspective, and to share the excitement of astronomy with the public. Knowing how the astronomical journey has proceeded thus far allows current professionals to map where to go next and how to get there. The column charts the first part of this journey by celebrating anniversaries of births, discoveries, and deaths, and the technological advances that made discoveries possible. A new “Further Reading” section encourages readers to pursue subjects in greater depth and strengthens the articles as classroom resources.In the months preceding the 21 August 2017 solar eclipse, the column featured astronomical bodies that come between Earth and the Sun: 2004 Venus transit, the 1878 solar eclipse, and the search for the hypothetical planet Vulcan. Venusian transits were an early but technically challenging way to measure the astronomical unit, now easily done with radar-ranging. Like this year’s event, eclipse chasing and citizen science were part of the 1878 experience. Newton’s Laws seemed to require a planet inside Mercury’s orbit, but General Relativity explained the behavior of Mercury without it. Studying each of these transiting bodies has expanded our knowledge and understanding of the universe differently. Transiting extrasolar planets remain to be explored in a future column. In September, an article on the discovery of Neptune followed the discussion of the non-existent Vulcan quite naturally and expanded on the brief mention of this event in relation to the discovery of Pluto. Suggestions for additional topics are always welcome.The Dudley Observatory

  3. Validation of King's transaction process for healthcare provider-patient communication in pharmaceutical context: One cross-sectional study.

    Science.gov (United States)

    Wang, Dan; Liu, Chenxi; Zhang, Zinan; Ye, Liping; Zhang, Xinping

    2018-03-27

    With the impressive advantages of patient-pharmacist communication being advocated and poor pharmacist-patient communication in different settings, it is of great significance and urgency to explore the mechanism of the pharmacist-patient communicative relationship. The King's theory of goal attainment is proposed as one of the most promising models to be applied, because it takes into consideration both improving the patient-pharmacist relationship and attaining patients' health outcomes. This study aimed to validate the King's transaction process and build the linkage between the transaction process and patient satisfaction in a pharmaceutical context. A cross-sectional study was conducted in four tertiary hospitals in two provincial cities (Wuhan and Shanghai) in central and east China in July 2017. Patients over 18 were investigated in the pharmacies of the hospitals. The instrument for the transaction process was revised and tested. Path analysis was conducted for the King's transaction process and its relationship with patient satisfaction. Five hundred eighty-nine participants were investigated for main study. Prior to the addition of covariates, the hypothesised model of the King's transaction process was validated, in which all paths of the transaction process were statistically significant (p process had direct effects on patient satisfaction (p process was established as one valid theoretical framework of healthcare provider-patient communication in a pharmaceutical context. Copyright © 2018 Elsevier Inc. All rights reserved.

  4. Providing visualisation support for the analysis of anatomy ontology data

    Directory of Open Access Journals (Sweden)

    Burger Albert

    2005-03-01

    Full Text Available Abstract Background Improvements in technology have been accompanied by the generation of large amounts of complex data. This same technology must be harnessed effectively if the knowledge stored within the data is to be retrieved. Storing data in ontologies aids its management; ontologies serve as controlled vocabularies that promote data exchange and re-use, improving analysis. The Edinburgh Mouse Atlas Project stores the developmental stages of the mouse embryo in anatomy ontologies. This project is looking at the use of visual data overviews for intuitive analysis of the ontology data. Results A prototype has been developed that visualises the ontologies using directed acyclic graphs in two dimensions, with the ability to study detail in regions of interest in isolation or within the context of the overview. This is followed by the development of a technique that layers individual anatomy ontologies in three-dimensional space, so that relationships across multiple data sets may be mapped using physical links drawn along the third axis. Conclusion Usability evaluations of the applications confirmed advantages in visual analysis of complex data. This project will look next at data input from multiple sources, and continue to develop the techniques presented to provide intuitive identification of relationships that span multiple ontologies.

  5. Context Dependent Analysis of BioAmbients

    DEFF Research Database (Denmark)

    Pilegaard, Henrik; Nielson, Flemming; Nielson, Hanne Riis

    2006-01-01

    BioAmbients is a derivative of mobile ambients that has shown promise of describing interesting features of the behaviour of biological systems. The technical contribution of this paper is to extend the Flow Logic approach to static analysis with a couple of new techniques in order to give precise...... information about the behaviour of systems written in BioAmbients. Applying the development to a simple model of a cell releasing nutrients from food compunds we illustrate how the proposed analysis does indeed improve on previous efforts....

  6. A Historical Context Analysis of Changes in Content Management Ideology

    National Research Council Canada - National Science Library

    Lee, William, Jr

    2005-01-01

    .... This research will be a qualitative study using a combined approach of historical and context analysis of literary artifacts for drawing inferences to explore the evolutionary changes in content management ideology...

  7. Which Societies Provide a Strong Religious Socialization Context? Explanations Beyond the Effects of National Religiosity

    OpenAIRE

    Müller, Tim; De Graaf, Nan Dirk; Schmidt, Peter

    2014-01-01

    Religious socialization occurs within the immediate family as well as in the broader social context. Previous research has shown that parents religiosity matters less for the transmission of religious beliefs in devout than in secular nations, implying smaller costs of religious socialization. In this article we test which other societal factors affect the transmission of religious beliefs: anti-religious policies in formerly socialist countries, economic development, and income inequality. O...

  8. Providing context for a medical school basic science curriculum: The importance of the humanities.

    Science.gov (United States)

    Thompson, Britta M; Vannatta, Jerry B; Scobey, Laura E; Fergeson, Mark; Humanities Research Group; Crow, Sheila M

    2016-01-01

    To increase students' understanding of what it means to be a physician and engage in the everyday practice of medicine, a humanities program was implemented into the preclinical curriculum of the medical school curriculum. The purpose of our study was to determine how medical students' views of being a doctor evolved after participating in a required humanities course. Medical students completing a 16-clock hour humanities course from 10 courses were asked to respond to an open-ended reflection question regarding changes, if any, of their views of being a doctor. The constant comparative method was used for coding; triangulation and a variety of techniques were used to provide evidence of validity of the analysis. A majority of first- and second-year medical students (rr = 70%) replied, resulting in 100 pages of text. A meta-theme of Contextualizing the Purpose of Medicine and three subthemes: the importance of Treating Patients Rather than a Disease, Understanding Observation Skills are Important, and Recognizing that Doctors are Fallible emerged from the data. Results suggest that requiring humanities as part of the required preclinical curriculum can have a positive influence on medical students and act as a bridge to contextualize the purpose of medicine.

  9. Analysis of Characteristics of Power Consumption for Context-Aware Mobile Applications

    Directory of Open Access Journals (Sweden)

    Meeyeon Lee

    2014-11-01

    Full Text Available In recent years, a large portion of smartphone applications (Apps has targeted context-aware services. They aim to perceive users’ real-time context like his/her location, actions, or even emotion, and to provide various customized services based on the inferred context. However, context-awareness in mobile environments has some challenging issues due to limitations of devices themselves. Limited power is regarded as the most critical problem in context-awareness on smartphones. Many studies have tried to develop low-power methods, but most of them have focused on the power consumption of H/W modules of smartphones such as CPU and LCD. Only a few research papers have recently started to present some S/W-based approaches to improve the power consumption. That is, previous works did not consider energy consumed by context-awareness of Apps. Therefore, in this paper, we focus on the power consumption of context-aware Apps. We analyze the characteristics of context-aware Apps in a perspective of the power consumption, and then define two main factors which significantly influence the power consumption: a sort of context that context-aware Apps require for their services and a type of ways that a user uses them. The experimental result shows the reasonability and the possibility to develop low-power methods based on our analysis. That is, our analysis presented in this paper will be a foundation for energy-efficient context-aware services in mobile environments.

  10. Microblog sentiment analysis using social and topic context.

    Science.gov (United States)

    Zou, Xiaomei; Yang, Jing; Zhang, Jianpei

    2018-01-01

    Analyzing massive user-generated microblogs is very crucial in many fields, attracting many researchers to study. However, it is very challenging to process such noisy and short microblogs. Most prior works only use texts to identify sentiment polarity and assume that microblogs are independent and identically distributed, which ignore microblogs are networked data. Therefore, their performance is not usually satisfactory. Inspired by two sociological theories (sentimental consistency and emotional contagion), in this paper, we propose a new method combining social context and topic context to analyze microblog sentiment. In particular, different from previous work using direct user relations, we introduce structure similarity context into social contexts and propose a method to measure structure similarity. In addition, we also introduce topic context to model the semantic relations between microblogs. Social context and topic context are combined by the Laplacian matrix of the graph built by these contexts and Laplacian regularization are added into the microblog sentiment analysis model. Experimental results on two real Twitter datasets demonstrate that our proposed model can outperform baseline methods consistently and significantly.

  11. A Context-Aware Model to Provide Positioning in Disaster Relief Scenarios

    Directory of Open Access Journals (Sweden)

    Daniel Moreno

    2015-09-01

    Full Text Available The effectiveness of the work performed during disaster relief efforts is highly dependent on the coordination of activities conducted by the first responders deployed in the affected area. Such coordination, in turn, depends on an appropriate management of geo-referenced information. Therefore, enabling first responders to count on positioning capabilities during these activities is vital to increase the effectiveness of the response process. The positioning methods used in this scenario must assume a lack of infrastructure-based communication and electrical energy, which usually characterizes affected areas. Although positioning systems such as the Global Positioning System (GPS have been shown to be useful, we cannot assume that all devices deployed in the area (or most of them will have positioning capabilities by themselves. Typically, many first responders carry devices that are not capable of performing positioning on their own, but that require such a service. In order to help increase the positioning capability of first responders in disaster-affected areas, this paper presents a context-aware positioning model that allows mobile devices to estimate their position based on information gathered from their surroundings. The performance of the proposed model was evaluated using simulations, and the obtained results show that mobile devices without positioning capabilities were able to use the model to estimate their position. Moreover, the accuracy of the positioning model has been shown to be suitable for conducting most first response activities.

  12. Measuring the benefits of using market based approaches to provide water and sanitation in humanitarian contexts.

    Science.gov (United States)

    Martin-Simpson, S; Parkinson, J; Katsou, E

    2018-06-15

    The use of cash transfers and market based programming (CT/MBP) to increase the efficiency and effectiveness of emergency responses is gaining prominence in the humanitarian sector. However, there is a lack of existing indicators and methodologies to monitor activities designed to strengthen water and sanitation (WaSH) markets. Gender and vulnerability markers to measure the impact of such activities on different stakeholders is also missing. This study identifies parameters to monitor, evaluate and determine the added value of utilising CT/MBP to achieve WaSH objectives in humanitarian response. The results of the work revealed that CT/MBP can be used to support household, community and market level interventions to effectively reduce transmission of faeco-oral diseases. Efficiency, effectiveness, sustainability, appropriateness and equity were identified as useful parameters which correlated to widely accepted frameworks against which to evaluate humanitarian action. The parameters were found to be directly applicable to the case of increasing demand and supply of point of use water treatment technology for a) disaster resilience activities, and b) post-crisis response. The need for peer review of the parameters and indicators and pilot measurement in humanitarian contexts was recognised. Copyright © 2017 Elsevier Ltd. All rights reserved.

  13. A Context-Aware Ubiquitous Learning Approach for Providing Instant Learning Support in Personal Computer Assembly Activities

    Science.gov (United States)

    Hsu, Ching-Kun; Hwang, Gwo-Jen

    2014-01-01

    Personal computer assembly courses have been recognized as being essential in helping students understand computer structure as well as the functionality of each computer component. In this study, a context-aware ubiquitous learning approach is proposed for providing instant assistance to individual students in the learning activity of a…

  14. Measuring Provider Attitudes Toward Evidence-Based Practice: Consideration of Organizational Context and Individual Differences

    OpenAIRE

    Aarons, Gregory A.

    2005-01-01

    Mental health provider attitudes toward adoption of innovation in general, and toward evidence-based practice (EBP) in particular, are important in considering how best to disseminate and implement EBPs. This article first explores the role of attitudes in acceptance of innovation and proposes a model of organizational and individual factors that may affect or be affected by attitudes toward adoption of EBP. Next, a recently developed measure of mental health provider attitudes toward adoptio...

  15. Changing Provider Behavior in the Context of Chronic Disease Management: Focus on Clinical Inertia.

    Science.gov (United States)

    Lavoie, Kim L; Rash, Joshua A; Campbell, Tavis S

    2017-01-06

    Widespread acceptance of evidence-based medicine has led to the proliferation of clinical practice guidelines as the primary mode of communicating current best practices across a range of chronic diseases. Despite overwhelming evidence supporting the benefits of their use, there is a long history of poor uptake by providers. Nonadherence to clinical practice guidelines is referred to as clinical inertia and represents provider failure to initiate or intensify treatment despite a clear indication to do so. Here we review evidence for the ubiquity of clinical inertia across a variety of chronic health conditions, as well as the organizational and system, patient, and provider factors that serve to maintain it. Limitations are highlighted in the emerging literature examining interventions to reduce clinical inertia. An evidence-based framework to address these limitations is proposed that uses behavior change theory and advocates for shared decision making and enhanced guideline development and dissemination.

  16. Modern approaches to quintessence of public accounting of enterprise in context of economical safety providing

    Directory of Open Access Journals (Sweden)

    L.V. Gnilitskaya

    2016-07-01

    Full Text Available Discrepancy of possibilities of modern accounting to the demands of economical safety directed for the satisfaction of informational needs of various groups of users of accounting in order they could make grounded and timely management decisions while providing stable and steady functioning both an enterprise and a region where this enterprise runs and also a state as a whole, has caused the necessity of searching for other concepts and the models of accounting information formation. The research proves that the most advantages for economical safety providing belong to the concept of cost accounting. The use of this concept will allow to identify the information necessary for the sides interested in it; to model external corporation accounting including field peculiarities of an enterprise; to disclose the information concerning not only to internal parameters but also to external environment where the enterprise functions; to assess the risks of businesses and show their influence in corresponding forms of accounting. The adaptation of the concept of cost accounting into the practice of home enterprises (if the informational needs of economical safety are provided will require definite changes in the structure and contents of accounting information, on one hand, and the improvement (view, shift of the principles of preparation of accounting as the accounting base, on the other hand.

  17. Providing the Larger Climate Context During Extreme Weather - Lessons from Local Television News

    Science.gov (United States)

    Woods, M.; Cullen, H. M.

    2015-12-01

    Local television weathercasters, in their role as Station Scientists, are often called upon to educate viewers about the science and impacts of climate change. Climate Central supports these efforts through its Climate Matters program. Launched in 2010 with support from the National Science Foundation, the program has grown into a network that includes more than 245 weathercasters from across the country and provides localized information on climate and ready-to-use, broadcast quality graphics and analyses in both English and Spanish. This presentation will focus on discussing best practices for integrating climate science into the local weather forecast as well as advances in the science of extreme event attribution. The Chief Meteorologist at News10 (Sacramento, CA) will discuss local news coverage of the ongoing California drought, extreme weather and climate literacy.

  18. Providing clinicians and patients with actual prognosis: cancer in the context of competing causes of death.

    Science.gov (United States)

    Howlader, Nadia; Mariotto, Angela B; Woloshin, Steven; Schwartz, Lisa M

    2014-11-01

    To isolate progress against cancer from changes in competing causes of death, population cancer registries have traditionally reported cancer prognosis (net measures). But clinicians and cancer patients generally want to understand actual prognosis (crude measures): the chance of surviving, dying from the specific cancer and from competing causes of death in a given time period. To compare cancer and actual prognosis in the United States for four leading cancers-lung, breast, prostate, and colon-by age, comorbidity, and cancer stage and to provide templates to help patients, clinicians, and researchers understand actual prognosis. Using population-based registry data from the Surveillance, Epidemiology, and End Results (SEER) Program, we calculated cancer prognosis (relative survival) and actual prognosis (five-year overall survival and the "crude" probability of dying from cancer and competing causes) for three important prognostic determinants (age, comorbidity [Charlson-score from 2012 SEER-Medicare linkage dataset] and cancer stage at diagnosis). For younger, healthier, and earlier stage cancer patients, cancer and actual prognosis estimates were quite similar. For older and sicker patients, these prognosis estimates differed substantially. For example, the five-year overall survival for an 85-year-old patient with colorectal cancer is 54% (cancer prognosis) versus 22% (actual prognosis)-the difference reflecting the patient's substantial chance of dying from competing causes. The corresponding five-year chances of dying from the patient's cancer are 46% versus 37%. Although age and comorbidity lowered actual prognosis, stage at diagnosis was the most powerful factor: The five-year chance of colon cancer death was 10% for localized stage and 83% for distant stage. Both cancer and actual prognosis measures are important. Cancer registries should routinely report both cancer and actual prognosis to help clinicians and researchers understand the difference between

  19. Concept analysis: patient autonomy in a caring context.

    Science.gov (United States)

    Lindberg, Catharina; Fagerström, Cecilia; Sivberg, Bengt; Willman, Ania

    2014-10-01

    This paper is a report of an analysis of the concept of patient autonomy Many problems regarding patient autonomy in healthcare contexts derive from the patient's dependent condition as well as the traditional authoritarian position of healthcare professionals. Existing knowledge and experience reveal a lack of consensus among nurses regarding the meaning of this ethical concept. Concept analysis. Medline, CINAHL, The Cochrane Library and PsycINFO were searched (2005-June 2013) using the search blocks 'autonomy', 'patient' and 'nursing/caring'. A total of 41 articles were retrieved. The Evolutionary Method of Concept Analysis by Rodgers was used to identify and construct the meaning of the concept of patient autonomy in a caring context. Five attributes were identified, thus creating the following descriptive definition: 'Patient autonomy is a gradual, time-changing process of (re-)constructing autonomy through the interplay of to be seen as a person, the capacity to act and the obligation to take responsibility for one's actions'. Patient vulnerability was shown to be the antecedent of patient autonomy and arises due to an impairment of a person's physical and/or mental state. The consequences of patient autonomy were discussed in relation to preserving control and freedom. Patient autonomy in a caring context does not need to be the same before, during and after a care episode. A tentative model has been constructed, thus extending the understanding of this ethical concept in a caring context. © 2014 John Wiley & Sons Ltd.

  20. Context

    Directory of Open Access Journals (Sweden)

    Sugam Sharma

    2015-11-01

    Full Text Available The primary thrust of this work is to demonstrate the applicability of association rule mining in public health domain, focusing on physical activity and exercising. In this paper, the concept of association rule mining is shown assisting to promote the physical exercise as regular human activity. Specifically, similar to the prototypical example of association rule mining, market basket analysis, our proposed novel approach considers two events – exercise (sporadic and sleep (regular as the two items of the frequent set; and associating the former, exercise event, with latter, the daily occurring activity sleep at night, helps strengthening the frequency of the exercise patterns. The regularity can further be enhanced, if the exercising instruments are kept in the vicinity of the bed and are within easy reach.

  1. Research and Practice Communications Between Oral Health Providers and Prenatal Health Providers: A Bibliometric Analysis.

    Science.gov (United States)

    Skvoretz, John; Dyer, Karen; Daley, Ellen; Debate, Rita; Vamos, Cheryl; Kline, Nolan; Thompson, Erika

    2016-08-01

    Objectives We aimed to examine scholarly collaboration between oral health and prenatal providers. Oral disease is a silent epidemic with significant public health implications for pregnant women. Evidence linking poor oral health during pregnancy to adverse pregnancy and birth outcomes requires oral health and prenatal providers to communicate on the prevention, treatment and co-management matters pertaining to oral health issues among their pregnant patients. The need for inter-professional collaboration is highlighted by guidelines co-endorsed by the American College of Obstetricians and Gynecologists and the American Dental Association, stressing the importance of oral health care during pregnancy. Methods To assess if interdisciplinary communication occurs between oral health and prenatal disciplines, we conducted a network analysis of research on pregnancy-related periodontal disease. Results Social Network analysis allowed us to identify communication patterns between communities of oral health and prenatal professionals via scientific journals. Analysis of networks of citations linking journals in different fields reveals a core-periphery pattern dominated by oral health journals with some participation from medicine journals. However, an analysis of dyadic ties of citation reveals statistically significant "inbreeding" tendencies in the citation patterns: both medical and oral health journals tend to cite their own kind at greater-than-chance levels. Conclusions Despite evidence suggesting that professional collaboration benefits patients' overall health, findings from this research imply that little collaboration occurs between these two professional groups. More collaboration may be useful in addressing women's oral-systemic health concerns that result in adverse pregnancy outcomes.

  2. Context and Natural Language in Formal Concept Analysis

    DEFF Research Database (Denmark)

    Wray, Tim; Eklund, Peter

    2017-01-01

    perspectives that emphasise the importance of the human, social and cultural contexts that are associated with objects. This paper presents an application of these museological concepts as related to the principles of Formal Concept Analysis along with a description of how the CollectionWeb framework generates......CollectionWeb is a framework that uses Formal Concept Analysis (FCA) to link contextually related objects within museum collections. These connections are used to drive a number of user interactions that are intended to promote exploration and discovery. The idea is based on museological...

  3. Decision theory, the context for risk and reliability analysis

    International Nuclear Information System (INIS)

    Kaplan, S.

    1985-01-01

    According to this model of the decision process then, the optimum decision is that option having the largest expected utility. This is the fundamental model of a decision situation. It is necessary to remark that in order for the model to represent a real-life decision situation, it must include all the options present in that situation, including, for example, the option of not deciding--which is itself a decision, although usually not the optimum one. Similarly, it should include the option of delaying the decision while the authors gather further information. Both of these options have probabilities, outcomes, impacts, and utilities like any option and should be included explicitly in the decision diagram. The reason for doing a quantitative risk or reliability analysis is always that, somewhere underlying there is a decision to be made. The decision analysis therefore always forms the context for the risk or reliability analysis, and this context shapes the form and language of that analysis. Therefore, they give in this section a brief review of the well-known decision theory diagram

  4. Provider attributes correlation analysis to their referral frequency and awards.

    Science.gov (United States)

    Wiley, Matthew T; Rivas, Ryan L; Hristidis, Vagelis

    2016-03-14

    There has been a recent growth in health provider search portals, where patients specify filters-such as specialty or insurance-and providers are ranked by patient ratings or other attributes. Previous work has identified attributes associated with a provider's quality through user surveys. Other work supports that intuitive quality-indicating attributes are associated with a provider's quality. We adopt a data-driven approach to study how quality indicators of providers are associated with a rich set of attributes including medical school, graduation year, procedures, fellowships, patient reviews, location, and technology usage. In this work, we only consider providers as individuals (e.g., general practitioners) and not organizations (e.g., hospitals). As quality indicators, we consider the referral frequency of a provider and a peer-nominated quality designation. We combined data from the Centers for Medicare and Medicaid Services (CMS) and several provider rating web sites to perform our analysis. Our data-driven analysis identified several attributes that correlate with and discriminate against referral volume and peer-nominated awards. In particular, our results consistently demonstrate that these attributes vary by locality and that the frequency of an attribute is more important than its value (e.g., the number of patient reviews or hospital affiliations are more important than the average review rating or the ranking of the hospital affiliations, respectively). We demonstrate that it is possible to build accurate classifiers for referral frequency and quality designation, with accuracies over 85 %. Our findings show that a one-size-fits-all approach to ranking providers is inadequate and that provider search portals should calibrate their ranking function based on location and specialty. Further, traditional filters of provider search portals should be reconsidered, and patients should be aware of existing pitfalls with these filters and educated on local

  5. Qualitative uncertainty analysis in probabilistic safety assessment context

    International Nuclear Information System (INIS)

    Apostol, M.; Constantin, M; Turcu, I.

    2007-01-01

    In Probabilistic Safety Assessment (PSA) context, an uncertainty analysis is performed either to estimate the uncertainty in the final results (the risk to public health and safety) or to estimate the uncertainty in some intermediate quantities (the core damage frequency, the radionuclide release frequency or fatality frequency). The identification and evaluation of uncertainty are important tasks because they afford credit to the results and help in the decision-making process. Uncertainty analysis can be performed qualitatively or quantitatively. This paper performs a preliminary qualitative uncertainty analysis, by identification of major uncertainty in PSA level 1- level 2 interface and in the other two major procedural steps of a level 2 PSA i.e. the analysis of accident progression and of the containment and analysis of source term for severe accidents. One should mention that a level 2 PSA for a Nuclear Power Plant (NPP) involves the evaluation and quantification of the mechanisms, amount and probabilities of subsequent radioactive material releases from the containment. According to NUREG 1150, an important task in source term analysis is fission products transport analysis. The uncertainties related to the isotopes distribution in CANDU NPP primary circuit and isotopes' masses transferred in the containment, using SOPHAEROS module from ASTEC computer code will be also presented. (authors)

  6. On Special Functions in the Context of Clifford Analysis

    Science.gov (United States)

    Malonek, H. R.; Falcão, M. I.

    2010-09-01

    Considering the foundation of Quaternionic Analysis by R. Fueter and his collaborators in the beginning of the 1930s as starting point of Clifford Analysis, we can look back to 80 years of work in this field. However the interest in multivariate analysis using Clifford algebras only started to grow significantly in the 70s. Since then a great amount of papers on Clifford Analysis referring different classes of Special Functions have appeared. This situation may have been triggered by a more systematic treatment of monogenic functions by their multiple series development derived from Gegenbauer or associated Legendre polynomials (and not only by their integral representation). Also approaches to Special Functions by means of algebraic methods, either Lie algebras or through Lie groups and symmetric spaces gained by that time importance and influenced their treatment in Clifford Analysis. In our talk we will rely on the generalization of the classical approach to Special Functions through differential equations with respect to the hypercomplex derivative, which is a more recently developed tool in Clifford Analysis. In this context special attention will be payed to the role of Special Functions as intermediator between continuous and discrete mathematics. This corresponds to a more recent trend in combinatorics, since it has been revealed that many algebraic structures have hidden combinatorial underpinnings.

  7. European practices of providing of efficiency of self-organizations institutions of population in the context of public services

    Directory of Open Access Journals (Sweden)

    T. V. Serohina

    2017-06-01

    Full Text Available The research revealed that European countries devote sufficient attention to ensuring the effectiveness of the institutions of self-organization in the context of their public services. The most common areas where they operate are a system of health, education and assistance during emergencies. The study showed that in the development of public services, there were significant transformations in terms of subject-provider. Historically it was confessional organizations working on a voluntary basis, and linked their activity with the realization of Christian mission. Subsequently, when there had been formation of a «welfare state», the state took over responsibility for the area of public services. In favor of institutions of self-organization has been a change in the system when it became clear that they are best in the provide public services, especially in the social sphere, because they are the demonstrating of social needs. The main mechanisms of cooperation between institutions of self-organization and the public sector are, first, subsidies for statutory activities of the organization. Another mechanism is delegating services or outsourcing and in this case contracts mostly are for one year with possibility of further extension. In addition there is auxiliary element of providing of effectiveness institutions of self-organization, it consists in deprivation of their donors from taxes. Although institutions of self-organization are financed mainly by public authorities, they remain independent, because they have opportunity of funding from other sources. German experience showed that the starting point in the system of public services is the understanding of the necessity of paying taxes as acknowledgment of the rights of all members of society. That is why every taxpayer expects to receive public services at the appropriate level. This unwritten rule contributes to a very high level of provision of public services through an adequate

  8. Academy of Nutrition and Dietetics benchmarks for nutrition in child care 2011: are child-care providers across contexts meeting recommendations?

    Science.gov (United States)

    Dev, Dipti A; McBride, Brent A

    2013-10-01

    The Academy of Nutrition and Dietetics (Academy) recommends feeding practices for child-care providers to establish nutrition habits in early childhood to prevent obesity. With >12 million US children in child care, little is known about child-care providers' feeding practices. The purpose of this study was to examine child-care providers' feeding practices to assess whether providers met the Academy's benchmarks and whether attainment of benchmarks varied across child-care contexts (Head Start, Child and Adult Care Food Program [CACFP], and non-CACFP). Cross-sectional data was collected in 2011 and 2012 from 118 child-care providers who completed self-administered surveys regarding their feeding practices for 2- to 5-year-old children. χ(2) tests and analysis of variance were used to determine variation across contexts. Head Start providers sat more frequently with children during meals (P=0.01), ate the same foods as children (P=0.001), and served meals family style (Pchildren (P=0.01) received more nutrition-education opportunities compared with CACFP and non-CACFP. Head Start providers encouraged more balance and variety of foods (Pchildren about nutrition (PAcademy's benchmarks compared with CACFP and non-CACFP providers. Possible reasons for this compliance might be attributed to Head Start nutrition performance standards and increased nutrition-training opportunities for Head Start staff. Head Start programs can serve as a model in implementing the Academy's benchmarks. Copyright © 2013 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved.

  9. Ubiquitous Geo-Sensing for Context-Aware Analysis: Exploring Relationships between Environmental and Human Dynamics

    Directory of Open Access Journals (Sweden)

    Euro Beinat

    2012-07-01

    Full Text Available Ubiquitous geo-sensing enables context-aware analyses of physical and social phenomena, i.e., analyzing one phenomenon in the context of another. Although such context-aware analysis can potentially enable a more holistic understanding of spatio-temporal processes, it is rarely documented in the scientific literature yet. In this paper we analyzed the collective human behavior in the context of the weather. We therefore explored the complex relationships between these two spatio-temporal phenomena to provide novel insights into the dynamics of urban systems. Aggregated mobile phone data, which served as a proxy for collective human behavior, was linked with the weather data from climate stations in the case study area, the city of Udine, Northern Italy. To identify and characterize potential patterns within the weather-human relationships, we developed a hybrid approach which integrates several spatio-temporal statistical analysis methods. Thereby we show that explanatory factor analysis, when applied to a number of meteorological variables, can be used to differentiate between normal and adverse weather conditions. Further, we measured the strength of the relationship between the ‘global’ adverse weather conditions and the spatially explicit effective variations in user-generated mobile network traffic for three distinct periods using the Maximal Information Coefficient (MIC. The analyses result in three spatially referenced maps of MICs which reveal interesting insights into collective human dynamics in the context of weather, but also initiate several new scientific challenges.

  10. Enablement in health care context: a concept analysis.

    Science.gov (United States)

    Hudon, Catherine; St-Cyr Tribble, Denise; Bravo, Gina; Poitras, Marie-Eve

    2011-02-01

    The enablement process is defined as a professional intervention aiming to recognize, support and emphasize the patient's capacity to have control over her or his health and life. The purpose of this article was to study the enablement concept through a concept analysis in the health care context to identify: (1) its attributes and (2) its antecedents and consequents. A concept analysis was performed according to the method of Rodgers. The literature was reviewed from 1980 to June 2008, using search strategies adapted to the databases Cinahl, Medline, Embase, PsycInfo and Social Works Abstract, and hand searching. All articles contributing to a deeper understanding of the concept were included. The analysis was carried out according to a thematic analysis procedure, as described by Miles & Huberman. The search identified 1305 citations. After in-depth assessment of 148 potentially eligible citations, 61 articles were included in the review. Five articles were added with hand searching. Sixty-seven per cent of these articles were related to nursing. The attributes of the enablement concept included: contribution to the therapeutic relationship; consideration of the person as a whole; facilitation of learning; valorization of the person's strengths; implication and support to decision making; and broadening of the possibilities. These attributes could be used as a basis for other studies on enablement. Conceptual and empirical work is still needed to better position this concept among others such as patient-centred care, shared decision making and patient's participation. © 2010 Blackwell Publishing Ltd.

  11. How does care coordination provided by registered nurses "fit" within the organisational processes and professional relationships in the general practice context?

    Science.gov (United States)

    Ehrlich, Carolyn; Kendall, Elizabeth; St John, Winsome

    2013-01-01

    The aim of this study was to develop understanding about how a registered nurse-provided care coordination model can "fit" within organisational processes and professional relationships in general practice. In this project, registered nurses were involved in implementation of registered nurse-provided care coordination, which aimed to improve quality of care and support patients with chronic conditions to maintain their care and manage their lifestyle. Focus group interviews were conducted with nurses using a semi-structured interview protocol. Interpretive analysis of interview data was conducted using Normalization Process Theory to structure data analysis and interpretation. Three core themes emerged: (1) pre-requisites for care coordination, (2) the intervention in context, and (3) achieving outcomes. Pre-requisites were adequate funding mechanisms, engaging organisational power-brokers, leadership roles, and utilising and valuing registered nurses' broad skill base. To ensure registered nurse-provided care coordination processes were sustainable and embedded, mentoring and support as well as allocated time were required. Finally, when registered nurse-provided care coordination was supported, positive client outcomes were achievable, and transformation of professional practice and development of advanced nursing roles was possible. Registered nurse-provided care coordination could "fit" within the context of general practice if it was adequately resourced. However, the heterogeneity of general practice can create an impasse that could be addressed through close attention to shared and agreed understandings. Successful development and implementation of registered nurse roles in care coordination requires attention to educational preparation, support of the individual nurse, and attention to organisational structures, financial implications and team member relationships.

  12. The Analysis of Communicative Context Adaptation in English Advertisements

    Institute of Scientific and Technical Information of China (English)

    向凤雅; 杨婧; 张明耀

    2015-01-01

    Communicative context adaptation,a non-linguistic context is one of Verschueren's Adaptation Theory.To master key elements of communicative of communicative context adaptation help us in the process of advertisements translation. Here,we will detail it from the three aspects -the adaptation to the physical world,the mental world and the social world.

  13. The Analysis of Communicative Context Adaptation in English Advertisements

    Institute of Scientific and Technical Information of China (English)

    向凤雅; 杨婧; 张明耀

    2015-01-01

    Communicative context adaptation,a non-linguistic context is one of Verschueren’s Adaptation Theory.To master key elements of communicative of communicative context adaptation help us in the process of advertisements translation.Here,we will detail it from the three aspects-the adaptation to the physical world,the mental world and the social world.

  14. An analysis of zoo and aquarium provided teacher professional development

    Science.gov (United States)

    Kubarek-Sandor, Joy

    Informal science institutions are a significant provider of science teacher professional development. As pressure continues to critically analyze the work of teachers and their effectiveness in the classroom, it is important to understand how informal science institutions contribute to effective change in teacher science content knowledge and pedagogy. This research study analyzed zoo and aquarium provided teacher professional development to respond to the research questions: How do zoos and aquaria determine and assess their goals for teacher professional development? How do these goals align with effective teacher change for science content knowledge and pedagogy? Theoretical frameworks for high quality teacher professional development, effective evaluation of teacher professional development, and learning in informal science settings guided the research. The sample for the study was AZA accredited zoos and aquariums providing teacher professional development (N=107). Data collection consisted of an online questionnaire, follow-up interviews, and content analysis of teacher professional development artifacts. Analysis revealed that by and large zoos and aquariums are lacking in their provision of science teacher professional development. Most professional development focuses on content or resources, neglecting pedagogy. Assessments mismatch the goals and rely heavily on self-report and satisfaction measures. The results demonstrate a marked difference between those zoos and aquariums that are larger in capacity versus those that are medium to small in size. This may be an area of research for the future, as well as analyzing the education resources produced by zoos and aquariums as these were emphasized heavily as a way they serve teachers.

  15. Cost analysis and provider satisfaction with pediatrician in triage.

    Science.gov (United States)

    Kezirian, Janice; Muhammad, Warees T; Wan, Jim Y; Godambe, Sandip A; Pershad, Jay

    2012-10-01

    The goals of this study were to (1) conduct a cost-benefit analysis, from a hospital's perspective, of using a pediatrician in triage (PIT) in the emergency department (ED) and (2) assess the impact of a physician in triage on provider satisfaction. This was a prospective, controlled trial of PIT (intervention) versus conventional registered nurse-driven triage (control), at an urban, academic, tertiary level pediatric ED, which led to a cost-benefit analysis by looking at the effect that PIT has on length of stay (LOS) and thus on ED revenue. Provider satisfaction was assessed through surveys. During the 8-week study period, a total of 6579 patients were triaged: 3242 in the PIT group and 3337 in the control group. The 2 groups were similar in age, sex, admission rate, left-without-being-seen rate, and level of acuity. The mean LOS in the PIT group was 24.3 minutes shorter than in the control group. The costs of PIT seem to be increased and are not offset by savings; the net margin (total revenue minus costs) was $42,883 per year lower in the PIT than in the control group. Sensitivity analysis showed that if the LOS were reduced by more than 98.4 minutes, the cost savings would favor PIT. Most of the physicians and nurses (67%) reported that PIT facilitated their job. Placement of a PIT during periods of peak census resulted in shorter stay and notable provider satisfaction but at an incremental cost of $42,883 per year.

  16. Working at the intersection of context, culture, and technology: Provider perspectives on antimicrobial stewardship in the emergency department using electronic health record clinical decision support.

    Science.gov (United States)

    Chung, Phillip; Scandlyn, Jean; Dayan, Peter S; Mistry, Rakesh D

    2017-11-01

    Antibiotic stewardship programs (ASPs) have not been fully developed for the emergency department (ED), in part the result of the barriers characteristic of this setting. Electronic health record-based clinical decision support (EHR CDS) represents a promising strategy to implement ASPs in the ED. We aimed to determine the cultural beliefs and structural barriers and facilitators to implementation of antimicrobial stewardship in the pediatric ED using EHR CDS. Interviews and focus groups were conducted with hospital and ED leadership, attending ED physicians, nurse practitioners, physician assistants, and residents at a single health system in Colorado. We reviewed and coded the data using constant comparative analysis and framework analysis until a final set of themes emerged. Two dominant perceptions shaped providers' perspectives on ASPs in the ED and EHR CDS: (1) maintaining workflow efficiency and (2) constrained decision-making autonomy. Clinicians identified structural barriers to ASPs, such as pace of the ED, and various beliefs that shaped patterns of practice, including accommodating the prescribing decisions of other providers and managing parental expectations. Recommendations to enhance uptake focused on designing a simple yet flexible user interface, providing clinicians with performance data, and on-boarding clinicians to enhance buy-in. Developing a successful ED-based ASP using EHR CDS should attend to technologic needs, the institutional context, and the cultural beliefs of practice associated with providers' antibiotic prescribing. Copyright © 2017 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.

  17. ANALYSIS OF AGRARIAN SECTOR RESOURCE PROVIDING IN UKRAINE

    Directory of Open Access Journals (Sweden)

    Iryna Bezpyata

    2016-11-01

    Full Text Available The aim of this article is an analysis of material well-being level in agrarian sector of economy by productive resources (by land, labour, hardware providing with that provides efficiency of economic activity and ground of basic directions of the rational bringing in and use of resource potential of agrarian sector of economy in Ukraine in market conditions. Research methodology consists in the use of statistical and economic research methods for analysis of productive resources using modern state of agriculture for period from 2010 to 2014 years. Research results show that the resource providing agrarian sector development can be defined as totality of certain types of resources (land, technological, labour, financial and sources of their forming, directly participating in the processes of agrarian sector economies development that can be mobilized with the purpose of providing the scale using of their potential possibilities and transition of agriculture to the qualitatively new state. Analysis of the modern state of material well-being of agrarian sector resources of economy in Ukraine is unsatisfactory and with every year gets worse. To overcome this problem agricultural commodity producers are unable only by themselves. For the improvement of the economic state of agrarian sector of economy in whole country and regional state support of home agricultural producer, stimulation of his activity is needed. And first of all the self-weighted investment policy of the state should become such measures in the agrarian sector of economy that will allow bringing in of greater amount of investment resources for the improvement of technical equipment at agricultural enterprises, development of production co-operation and products sale, introduction of personnel management modern methodology, increase in labour activity level in agrarian sector, realization of the permanent updating and increase in products quality control, etc. Practical value. Got

  18. Plague cycles in two rodent species from China: Dry years might provide context for epizootics in wet years

    Science.gov (United States)

    Eads, David A.; Biggins, Dean E.; Xu, Lei; Liu, Qiyong

    2016-01-01

    Plague, a rodent-associated, flea-borne zoonosis, is one of the most notorious diseases in history. Rates of plague transmission can increase when fleas are abundant. Fleas commonly desiccate and die when reared under dry conditions in laboratories, suggesting fleas will be suppressed during droughts in the wild, thus reducing the rate at which plague spreads among hosts. In contrast, fleas might increase in abundance when precipitation is plentiful, producing epizootic outbreaks during wet years. We tested these hypotheses using a 27-yr data set from two rodents in Inner Mongolia, China: Mongolian gerbils (Meriones unguiculatus) and Daurian ground squirrels (Spermophilus dauricus). For both species of rodents, fleas were most abundant during years preceded by dry growing seasons. For gerbils, the prevalence of plague increased during wet years preceded by dry growing seasons. If precipitation is scarce during the primary growing season, succulent plants decline in abundance and, consequently, herbivorous rodents can suffer declines in body condition. Fleas produce more offspring and better survive when parasitizing food-limited hosts, because starving animals tend to exhibit inefficient behavioral and immunological defenses against fleas. Further, rodent burrows might buffer fleas from xeric conditions aboveground during dry years. After a dry year, fleas might be abundant due to the preceding drought, and if precipitation and succulent plants become more plentiful, rodents could increase in density, thereby creating connectivity that facilitates the spread of plague. Moreover, in wet years, mild temperatures might increase the efficiency at which fleas transmit the plague bacterium, while also helping fleas to survive as they quest among hosts. In this way, dry years could provide context for epizootics of plague in wet years.

  19. Comparative Analysis of Context-Dependent Mutagenesis Using Human and Mouse Models

    Directory of Open Access Journals (Sweden)

    Sofya A. Medvedeva

    2013-01-01

    Full Text Available Substitution rates strongly depend on their nucleotide context. One of the most studied examples is the excess of C > T mutations in the CG context in various groups of organisms, including vertebrates. Studies on the molecular mechanisms underlying this mutation regularity have provided insights into evolution, mutagenesis, and cancer development. Recently several other hypermutable motifs were identified in the human genome. There is an increased frequency of T > C mutations in the second position of the words ATTG and ATAG and an increased frequency of A > C mutations in the first position of the word ACAA. For a better understanding of evolution, it is of interest whether these mutation regularities are human specific or present in other vertebrates, as their presence might affect the validity of currently used substitution models and molecular clocks. A comprehensive analysis of mutagenesis in 4 bp mutation contexts requires a vast amount of mutation data. Such data may be derived from the comparisons of individual genomes or from single nucleotide polymorphism (SNP databases. Using this approach, we performed a systematical comparison of mutation regularities within 2–4 bp contexts in Mus musculus and Homo sapiens and uncovered that even closely related organisms may have notable differences in context-dependent mutation regularities.

  20. Providing a Foundation for Analysis of Volatile Data Stores

    Directory of Open Access Journals (Sweden)

    Timothy Vidas

    2007-09-01

    Full Text Available Current threats against typical computer systems demonstrate a need for forensic analysis of memory-resident data in addition to the conventional static analysis common today.  Certain attacks and types of malware exist solely in memory and leave little or no evidentiary information on nonvolatile stores such as a hard disk drive.  The desire to preserve system state at the time of response may even warrant memory acquisition independent of perceived threats and the ability to analyze the acquired duplicate. Tools capable of duplicating various types of volatile data stores are becoming widely available.  Once the data store has been duplicated, current forensic procedures have no method for extrapolating further useful information from the duplicate.  This paper is focused on providing the groundwork for performing forensic investigations on the data that is typically stored in a volatile data store, such as system RAM.It is intended that, when combined with good acquisition techniques, it will be shown that it is possible to obtain more post incident response information along with less impact to potential evidence when compared to typical incident response procedures. 

  1. Campus Health Centers' Lack of Information Regarding Providers: A Content Analysis of Division-I Campus Health Centers' Provider Websites.

    Science.gov (United States)

    Perrault, Evan K

    2018-07-01

    Campus health centers are a convenient, and usually affordable, location for college students to obtain health care. Staffed by licensed and trained professionals, these providers can generally offer similar levels of care that providers at off-campus clinics can deliver. Yet, previous research finds students may forgo this convenient, on-campus option partially because of a lack of knowledge regarding the quality of providers at these campus clinics. This study sought to examine where this information deficit may come from by analyzing campus health centers' online provider information. All Division-I colleges or universities with an on-campus health center, which had information on their websites about their providers (n = 294), had their providers' online information analyzed (n = 2,127 providers). Results revealed that schools commonly offer professional information (e.g., provider specialties, education), but very little about their providers outside of the medical context (e.g., hobbies) that would allow a prospective student patient to more easily relate. While 181 different kinds of credentials were provided next to providers' names (e.g., MD, PA-C, FNP-BC), only nine schools offered information to help students understand what these different credentials meant. Most schools had information about their providers within one-click of the homepage. Recommendations for improving online information about campus health center providers are offered.

  2. Social and philosophical analysis of brand clothes : the Ukrainian context

    Directory of Open Access Journals (Sweden)

    H. V. Skalatskaya

    2016-06-01

    Full Text Available The purpose of the article is to consider the prospects of social and philosophical analysis of the product (clothes of fashion brand. In social and philosophical analysis of brand clothes, its fashion shows there is a range of discursive questions: the use and the definition of the concepts «designer» and «brand»; thematic focus of the brand (fabrics, colors, prints, shapes its semantics; format of representation of fashion collection in dependence; and a number of other structural elements. In the analysis of fashion trends or seasonal collections the concepts designer or brand are used. The concept «brand» contains an economic component, certain calculations, and intangible assets (goodwill; design work is subject to market needs and the interests of consumers (for analysis of the individual designer the biographical method is used. Theoretical analysis of fashion cannot be made apart from empirical material. A performative approach of K. Wolfe can be the methodology of the social and philosophical research of fashion show. The advantages of this method of the research are to determine fashion as performative space, staging ideas of the designer in the fashion show and making clothes. Implementation of performative approach allowed considering thematic focus of the brand of clothes and format of its representation in seasonal fashion shows on the example of Ukrainian brand «Domanoff». Social and philosophical analysis of brand clothes can be divided into the following main components, excluding aesthetic and economic aspects: the use of the concepts designer and brand (a set of aesthetic, economic, social and subjective components and design`s view; review of the semantics of clothes and staging (by providing clothes in the form of seasonal fashion shows of collections. For complex social and socio­philosophical analysis of fashion brand it necessary to have: the press release (description, designer`s interview (disclosure of early

  3. Intrapreneurship in the Spanish context : a regional analysis

    NARCIS (Netherlands)

    Turro Sol, A.; Alvarez, Claudia; Urbano, David

    2016-01-01

    The objective of this article is to examine the influence of internal and external (environmental) factors on intrapreneurship in the Spanish context, considering differences among regions. Methodologically, the study applies logistic regression and uses data from the Spanish Global Entrepreneurship

  4. A systematic analysis of online marketing materials used by providers of expanded carrier screening.

    Science.gov (United States)

    Chokoshvili, Davit; Borry, Pascal; Vears, Danya F

    2017-12-14

    PurposeExpanded carrier screening (ECS) for a large number of recessive disorders is available to prospective parents through commercial providers. This study aimed to analyze the content of marketing materials on ECS providers' websites.MethodsTo identify providers of ECS tests, we undertook a comprehensive online search, reviewed recent academic literature on commercial carrier screening, and consulted with colleagues familiar with the current ECS landscape. The identified websites were archived in April 2017, and inductive content analysis was performed on website text, brochures and educational materials, and video transcripts.ResultsWe identified 18 ECS providers, including 16 commercial genetic testing companies. Providers typically described ECS as an important family planning tool. The content differed in both the tone used to promote ECS and the accuracy and completeness of the test information provided. We found that most providers offered complimentary genetic counseling to their consumers, although this was often optional, limited to the posttest context, and, in some cases, appeared to be available only to test-positive individuals.ConclusionThe quality of ECS providers' websites could be improved by offering more complete and accurate information about ECS and their tests. Providers should also ensure that all carrier couples receive posttest genetic counseling to inform their subsequent reproductive decision making.Genet Med advance online publication, 14 December 2017; doi:10.1038/gim.2017.222.

  5. Social network analysis provides insights into African swine fever epidemiology.

    Science.gov (United States)

    Lichoti, Jacqueline Kasiiti; Davies, Jocelyn; Kitala, Philip M; Githigia, Samuel M; Okoth, Edward; Maru, Yiheyis; Bukachi, Salome A; Bishop, Richard P

    2016-04-01

    Pig movements play a significant role in the spread of economically important infectious diseases such as the African swine fever. Characterization of movement networks between pig farms and through other types of farm and household enterprises that are involved in pig value chains can provide useful information on the role that different participants in the networks play in pathogen transmission. Analysis of social networks that underpin these pig movements can reveal pathways that are important in the transmission of disease, trade in commodities, the dissemination of information and the influence of behavioural norms. We assessed pig movements among pig keeping households within West Kenya and East Uganda and across the shared Kenya-Uganda border in the study region, to gain insight into within-country and trans-boundary pig movements. Villages were sampled using a randomized cluster design. Data were collected through interviews in 2012 and 2013 from 683 smallholder pig-keeping households in 34 villages. NodeXL software was used to describe pig movement networks at village level. The pig movement and trade networks were localized and based on close social networks involving family ties, friendships and relationships with neighbours. Pig movement network modularity ranged from 0.2 to 0.5 and exhibited good community structure within the network implying an easy flow of knowledge and adoption of new attitudes and beliefs, but also promoting an enhanced rate of disease transmission. The average path length of 5 defined using NodeXL, indicated that disease could easily reach every node in a cluster. Cross-border boar service between Uganda and Kenya was also recorded. Unmonitored trade in both directions was prevalent. While most pig transactions in the absence of disease, were at a small scale (sales during ASF outbreaks were to traders or other farmers from outside the sellers' village at a range of >10km. The close social relationships between actors in pig

  6. Implementation and Operational Analysis of an Interactive Intensive Care Unit within a Smart Health Context

    Science.gov (United States)

    Aguirre, Erik

    2018-01-01

    In the context of hospital management and operation, Intensive Care Units (ICU) are one of the most challenging in terms of time responsiveness and criticality, in which adequate resource management and signal processing play a key role in overall system performance. In this work, a context aware Intensive Care Unit is implemented and analyzed to provide scalable signal acquisition capabilities, as well as to provide tracking and access control. Wireless channel analysis is performed by means of hybrid optimized 3D Ray Launching deterministic simulation to assess potential interference impact as well as to provide required coverage/capacity thresholds for employed transceivers. Wireless system operation within the ICU scenario, considering conventional transceiver operation, is feasible in terms of quality of service for the complete scenario. Extensive measurements of overall interference levels have also been carried out, enabling subsequent adequate coverage/capacity estimations, for a set of Zigbee based nodes. Real system operation has been tested, with ad-hoc designed Zigbee wireless motes, employing lightweight communication protocols to minimize energy and bandwidth usage. An ICU information gathering application and software architecture for Visitor Access Control has been implemented, providing monitoring of the Boxes external doors and the identification of visitors via a RFID system. The results enable a solution to provide ICU access control and tracking capabilities previously not exploited, providing a step forward in the implementation of a Smart Health framework. PMID:29382148

  7. Implementation and Operational Analysis of an Interactive Intensive Care Unit within a Smart Health Context

    Directory of Open Access Journals (Sweden)

    Peio Lopez-Iturri

    2018-01-01

    Full Text Available In the context of hospital management and operation, Intensive Care Units (ICU are one of the most challenging in terms of time responsiveness and criticality, in which adequate resource management and signal processing play a key role in overall system performance. In this work, a context aware Intensive Care Unit is implemented and analyzed to provide scalable signal acquisition capabilities, as well as to provide tracking and access control. Wireless channel analysis is performed by means of hybrid optimized 3D Ray Launching deterministic simulation to assess potential interference impact as well as to provide required coverage/capacity thresholds for employed transceivers. Wireless system operation within the ICU scenario, considering conventional transceiver operation, is feasible in terms of quality of service for the complete scenario. Extensive measurements of overall interference levels have also been carried out, enabling subsequent adequate coverage/capacity estimations, for a set of Zigbee based nodes. Real system operation has been tested, with ad-hoc designed Zigbee wireless motes, employing lightweight communication protocols to minimize energy and bandwidth usage. An ICU information gathering application and software architecture for Visitor Access Control has been implemented, providing monitoring of the Boxes external doors and the identification of visitors via a RFID system. The results enable a solution to provide ICU access control and tracking capabilities previously not exploited, providing a step forward in the implementation of a Smart Health framework.

  8. Implementation and Operational Analysis of an Interactive Intensive Care Unit within a Smart Health Context.

    Science.gov (United States)

    Lopez-Iturri, Peio; Aguirre, Erik; Trigo, Jesús Daniel; Astrain, José Javier; Azpilicueta, Leyre; Serrano, Luis; Villadangos, Jesús; Falcone, Francisco

    2018-01-29

    In the context of hospital management and operation, Intensive Care Units (ICU) are one of the most challenging in terms of time responsiveness and criticality, in which adequate resource management and signal processing play a key role in overall system performance. In this work, a context aware Intensive Care Unit is implemented and analyzed to provide scalable signal acquisition capabilities, as well as to provide tracking and access control. Wireless channel analysis is performed by means of hybrid optimized 3D Ray Launching deterministic simulation to assess potential interference impact as well as to provide required coverage/capacity thresholds for employed transceivers. Wireless system operation within the ICU scenario, considering conventional transceiver operation, is feasible in terms of quality of service for the complete scenario. Extensive measurements of overall interference levels have also been carried out, enabling subsequent adequate coverage/capacity estimations, for a set of Zigbee based nodes. Real system operation has been tested, with ad-hoc designed Zigbee wireless motes, employing lightweight communication protocols to minimize energy and bandwidth usage. An ICU information gathering application and software architecture for Visitor Access Control has been implemented, providing monitoring of the Boxes external doors and the identification of visitors via a RFID system. The results enable a solution to provide ICU access control and tracking capabilities previously not exploited, providing a step forward in the implementation of a Smart Health framework.

  9. Systems analysis of transcriptome data provides new hypotheses about Arabidopsis root response to nitrate treatments

    Directory of Open Access Journals (Sweden)

    Javier eCanales

    2014-02-01

    Full Text Available Nitrogen (N is an essential macronutrient for plant growth and development. Plants adapt to changes in N availability partly by changes in global gene expression. We integrated publicly available root microarray data under contrasting nitrate conditions to identify new genes and functions important for adaptive nitrate responses in Arabidopsis thaliana roots. Overall, more than two thousand genes exhibited changes in expression in response to nitrate treatments in Arabidopsis thaliana root organs. Global regulation of gene expression by nitrate depends largely on the experimental context. However, despite significant differences from experiment to experiment in the identity of regulated genes, there is a robust nitrate response of specific biological functions. Integrative gene network analysis uncovered relationships between nitrate-responsive genes and eleven highly co-expressed gene clusters (modules. Four of these gene network modules have robust nitrate responsive functions such as transport, signaling and metabolism. Network analysis hypothesized G2-like transcription factors are key regulatory factors controlling transport and signaling functions. Our meta-analysis highlights the role of biological processes not studied before in the context of the nitrate response such as root hair development and provides testable hypothesis to advance our understanding of nitrate responses in plants.

  10. Teaching technical writing in multilingual contexts: a meta-analysis

    NARCIS (Netherlands)

    Winberg, Christine; van der Geest, Thea; Lehman, Barbara; Nduna, Joyce

    2010-01-01

    Teachers of technical and professional writing in Science, Engineering and Technology (SET) Programmes need to understand the particular needs and social contexts of students for whom English is not a first language. The focus of this paper is on technical writing, and the paper presents the

  11. Surveys and Analysis of RFI in The Smos Context

    DEFF Research Database (Denmark)

    Skou, Niels; Balling, Jan E.; Søbjærg, Sten Schmidl

    2010-01-01

    Several soil moisture and sea salinity campaigns, including airborne L-band radiometer measurements, have been carried out in preparation for the ESA Soil Moisture and Ocean Salinity (SMOS) mission. The radiometer used in this context is fully polarimetric and is capable of detecting Radio...

  12. Chemistry in Context: Analysis of Thematic Chemistry Videos Available Online

    Science.gov (United States)

    Christensson, Camilla; Sjöström, Jesper

    2014-01-01

    United Nations declared 2011 to be the International Year of Chemistry. The Swedish Chemical Society chose twelve themes, one for each month, to highlight the connection of chemistry with everyday life. Examples of themes were fashion, climate change, love, sports, communication, health issues, and food. From the themes various context-based…

  13. Providing Nuclear Criticality Safety Analysis Education through Benchmark Experiment Evaluation

    International Nuclear Information System (INIS)

    Bess, John D.; Briggs, J. Blair; Nigg, David W.

    2009-01-01

    One of the challenges that today's new workforce of nuclear criticality safety engineers face is the opportunity to provide assessment of nuclear systems and establish safety guidelines without having received significant experience or hands-on training prior to graduation. Participation in the International Criticality Safety Benchmark Evaluation Project (ICSBEP) and/or the International Reactor Physics Experiment Evaluation Project (IRPhEP) provides students and young professionals the opportunity to gain experience and enhance critical engineering skills.

  14. Effective methods of consumer protection in Brazil. An analysis in the context of property development contracts

    Directory of Open Access Journals (Sweden)

    Deborah Alcici Salomão

    2015-12-01

    Full Text Available This study examines consumer protection in arbitration, especially under the example of property development contract disputes in Brazil. This is a very current issue in light of the presidential veto of consumer arbitration on May 26, 2015. The article discusses the arbitrability of these disputes based on Brazilian legislation and relevant case law. It also analyzes of the advantages, disadvantages and trends of consumer arbitration in the context of real estate contracts. The paper concludes by providing suggestions specific to consumer protection in arbitration based on this analysis.

  15. Model-based analysis of context-specific cognitive control

    Directory of Open Access Journals (Sweden)

    Joseph A. King

    2012-09-01

    Full Text Available Interference resolution is improved for stimuli presented in contexts (e.g. locations associated with frequent conflict. This phenomenon, the context-specific proportion congruent (CSPC effect, has challenged the traditional juxtaposition of automatic and controlled processing because it suggests that contextual cues can prime top-down control settings in a bottom-up manner. We recently obtained support for this priming of control hypothesis with fMRI by showing that CSPC effects are mediated by contextually-cued adjustments in processing selectivity. However, an equally plausible explanation is that CSPC effects reflect adjustments in response caution triggered by expectancy violations (i.e. prediction errors when encountering rare events as compared to common ones (e.g. high-conflict incongruent trials in a task context associated with infrequent conflict. Here, we applied a quantitative model of choice, the linear ballistic accumulator (LBA, to distil the reaction time and accuracy data from four independent samples that performed a modified flanker task into latent variables representing the psychological processes underlying task-related decision making. We contrasted models which differentially accounted for CSPC effects as arising either from contextually-cued shifts in the rate of sensory evidence accumulation (drift models or in the amount of evidence required to reach a decision (threshold models. For the majority of the participants, the LBA ascribed CSPC effects to increases in response threshold for contextually-infrequent trial types (e.g. low-conflict congruent trials in the frequent conflict context, suggesting that the phenomenon may reflect more a prediction error-triggered shift in decision criterion rather than enhanced sensory evidence accumulation under conditions of frequent conflict.

  16. Exploiting Social Context for Anticipatory Analysis of Human Movement

    Science.gov (United States)

    2012-10-01

    Formation Using a Social Network of Web Services: A Preliminary Investigation,” Procedia Computer Science , vol. 5, pp. 466–471, Jan. 2011. [Online...steering and obstacle behavior are incorporated into the tracking and goal prediction system. Task 4: Learning through Social Context. Deliverable...answering predictive questions about the behavior of a large social system. We developed a method for generating agent activity profiles from

  17. A microlevel analysis of residential context and travel time

    OpenAIRE

    Tim Schwanen; Martin Dijst; Frans M Dieleman

    2002-01-01

    The literature on the association between residential context and travel concentrates on distance traveled and modal choice, as these variables are the most important from an environmental perspective. Travel time has received less attention -- an unfortunate oversight in our view, as people's travel decisions are determined by time rather than by distance. By using data from the 1998 Netherlands National Travel Survey, we have considered travel time associated with trip purpose and transport...

  18. Concept analysis of acculturation in Filipino immigrants within health context.

    Science.gov (United States)

    Serafica, Reimund

    2011-01-01

    Although acculturation has been widely used as a health research variable among other immigrant populations, it is nonexistent to the Filipino immigrant population. Accurate assessment, measurement, and exploration of acculturation of Filipinos in the United States can help improve the overall health care of this population. The work of Walker and Avant is used as a guide to analyze and clarify the operational definition of acculturation of this group within the context of health. © 2011 Wiley Periodicals, Inc.

  19. Best Technical Approach Analysis (BTA) for Force Provider Wastewater Management

    Science.gov (United States)

    1994-07-07

    TC/ AEAGC- FMD (CONT) I L ,1 I* ATCD-SE SUBJECT: Operational Requirements Document (ORD) for the Force Provider (FP) DISTRIBUTION: (CONT) Commander...MISSION 09 OP"RATI09AL FTA "tI*E Of TNE ALTIENATIVEI ONIDPOWO ... OXIDATION P*N) OR W~AAGE LAC" (300 9900 1 1 fEE?) PERPO*M ... IWNAT ARt ?NJ PSINCIVAi

  20. Cost analysis of consolidated federally provided health care

    Science.gov (United States)

    2017-06-01

    Government Accountability Office JIT just-in time KPO Kaizen promotion offices LT lead time MHS Military Health System MRI magnetic resonance...a hospital that is only large enough for one MRI unit may need to hold it idle much of the time to permit emergency testing; whereas, a hospital...Center San Diego and San Diego VA hospital both provide outpatient pharmaceutical services. Duplication and redundancy of operating two separate

  1. Use Contexts and Usage Patterns of Interactive Case Simulation Tools by HIV Healthcare Providers in a Statewide Online Clinical Education Program.

    Science.gov (United States)

    Wang, Dongwen

    2017-01-01

    We analyzed four interactive case simulation tools (ICSTs) from a statewide online clinical education program. Results have shown that ICSTs are increasingly used by HIV healthcare providers. Smart phone has become the primary usage platform for specific ICSTs. Usage patterns depend on particular ICST modules, usage stages, and use contexts. Future design of ICSTs should consider these usage patterns for more effective dissemination of clinical evidence to healthcare providers.

  2. Systems and context modeling approach to requirements analysis

    Science.gov (United States)

    Ahuja, Amrit; Muralikrishna, G.; Patwari, Puneet; Subhrojyoti, C.; Swaminathan, N.; Vin, Harrick

    2014-08-01

    Ensuring completeness and correctness of the requirements for a complex system such as the SKA is challenging. Current system engineering practice includes developing a stakeholder needs definition, a concept of operations, and defining system requirements in terms of use cases and requirements statements. We present a method that enhances this current practice into a collection of system models with mutual consistency relationships. These include stakeholder goals, needs definition and system-of-interest models, together with a context model that participates in the consistency relationships among these models. We illustrate this approach by using it to analyze the SKA system requirements.

  3. Providing Contexts for Understanding Musical Narratives of Power in the Classroom: Music, Politics, and Power in Grenada, West Indies

    Science.gov (United States)

    Sirek, Danielle

    2016-01-01

    The role of music in Grenada, West Indies has traditionally been to pass on knowledges, values, and ideals; and to provide a means of connecting to one another through expressing commonality of experience, ancestry, and nationhood. This paper explores how Eric Matthew Gairy, during his era of political leadership in Grenada (1951-1979), exploited…

  4. An Ethical Analysis of Assisted Reproduction Providers' Websites in Pakistan.

    Science.gov (United States)

    Irshad, Ayesha; Werner-Felmayer, Gabriele

    2016-07-01

    Assisted reproductive technologies (ARTs) and reproductive genetic technologies (RGTs) are intertwined and coevolving. These technologies are increasingly used to fulfill socially and culturally framed requests, for example, "family balancing," or to enable postmenopausal women or homosexual couples to have genetically linked children. The areas of ART and RGT are replete with ethical issues, because different social practices and legal regulations, as well as economic inequalities within and among countries, create vulnerable groups and, therefore, the potential for exploitation. This article provides an overview of the ART and RGT landscape in Pakistan and analyzes the available online content addressing Pakistani citizens and international clients. We explored the topic in view of socioeconomic challenges in Pakistan, particularly deeply rooted poverty, lack of education, gender discrimination, and absence of regulation. As online information given by ART and RGT providers is readily available and could easily raise false hopes, make use of discriminatory statements with regard to women, and promote gender selection to meet sociocultural expectations, it should be subjected to quality control.

  5. Safe Spaces, Support, Social Capital: A Critical Analysis of Artists Working with Vulnerable Young People in Educational Contexts

    Science.gov (United States)

    Sellman, Edward

    2015-01-01

    This article provides a critical and thematic analysis of three research projects involving artists working with vulnerable young people in educational contexts. It argues that artists create safe spaces in contrast to traditional educational activities but it will also raise questions about what constitutes such a space for participants. It will…

  6. Vaginal Construction and Treatment Providers' Experiences: A Qualitative Analysis.

    Science.gov (United States)

    Roen, Katrina; Creighton, Sarah M; Hegarty, Peter; Liao, Lih-Mei

    2018-06-01

    To investigate specialist clinicians' experiences of treating vaginal agenesis. Semi-structured interviews. Twelve hospitals in Britain and Sweden. Thirty-two health professionals connected to multidisciplinary teams (MDTs) including medical specialists and psychologists. Theoretical thematic analysis of recorded verbatim data. The gynecologist and psychologist interviewees share certain observations including the importance of psychological readiness for and appropriate timing of treatment. Three overlapping themes are identified in our theoretical analysis of the MDT clinicians' talk: (1) the stigma of vaginal agenesis and the pressure to be "normal" can lead patients to minimize the time, effort, physical discomfort, and emotional cost inherent in treatment. (2) Under pressure, treatment might be presented to patients with insufficient attention to the potential psychological effect of the language used. Furthermore, the opportunity to question what is "normal" in sex is generally not taken up. It can be challenging to help the women to transcend their medicalized experiences to come to experiencing their bodies as sexual and enjoyable. (3) The reality of treatment demands, which are not always adequately processed before treatment, can lead to discontinuation and even disengagement with services. The MDT clinicians in this study emphasized the importance of psychological input in vaginal construction. However, such input should proactively question social norms about how women's genitalia should appear and function. Furthermore, rather than steering patients (back) to treatment, the entire MDT could more explicitly question social norms and help the women to do the same. By shifting the definition of success from anatomy to personal agency, the clinical focus is transformed from treatment to women. Copyright © 2018 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved.

  7. Principles of qualitative analysis in the chromatographic context.

    Science.gov (United States)

    Valcárcel, M; Cárdenas, S; Simonet, B M; Carrillo-Carrión, C

    2007-07-27

    This article presents the state of the art of qualitative analysis in the framework of the chromatographic analysis. After establishing the differences between two main classes of qualitative analysis (analyte identification and sample classification/qualification) the particularities of instrumental qualitative analysis are commented on. Qualitative chromatographic analysis for sample classification/qualification through the so-called chromatographic fingerprint (for complex samples) or the volatiles profile (through the direct coupling headspace-mass spectrometry using the chromatograph as interface) is discussed. Next, more technical exposition of the qualitative chromatographic information is presented supported by a variety of representative examples.

  8. Benchmarking undedicated cloud computing providers for analysis of genomic datasets.

    Science.gov (United States)

    Yazar, Seyhan; Gooden, George E C; Mackey, David A; Hewitt, Alex W

    2014-01-01

    A major bottleneck in biological discovery is now emerging at the computational level. Cloud computing offers a dynamic means whereby small and medium-sized laboratories can rapidly adjust their computational capacity. We benchmarked two established cloud computing services, Amazon Web Services Elastic MapReduce (EMR) on Amazon EC2 instances and Google Compute Engine (GCE), using publicly available genomic datasets (E.coli CC102 strain and a Han Chinese male genome) and a standard bioinformatic pipeline on a Hadoop-based platform. Wall-clock time for complete assembly differed by 52.9% (95% CI: 27.5-78.2) for E.coli and 53.5% (95% CI: 34.4-72.6) for human genome, with GCE being more efficient than EMR. The cost of running this experiment on EMR and GCE differed significantly, with the costs on EMR being 257.3% (95% CI: 211.5-303.1) and 173.9% (95% CI: 134.6-213.1) more expensive for E.coli and human assemblies respectively. Thus, GCE was found to outperform EMR both in terms of cost and wall-clock time. Our findings confirm that cloud computing is an efficient and potentially cost-effective alternative for analysis of large genomic datasets. In addition to releasing our cost-effectiveness comparison, we present available ready-to-use scripts for establishing Hadoop instances with Ganglia monitoring on EC2 or GCE.

  9. Benchmarking undedicated cloud computing providers for analysis of genomic datasets.

    Directory of Open Access Journals (Sweden)

    Seyhan Yazar

    Full Text Available A major bottleneck in biological discovery is now emerging at the computational level. Cloud computing offers a dynamic means whereby small and medium-sized laboratories can rapidly adjust their computational capacity. We benchmarked two established cloud computing services, Amazon Web Services Elastic MapReduce (EMR on Amazon EC2 instances and Google Compute Engine (GCE, using publicly available genomic datasets (E.coli CC102 strain and a Han Chinese male genome and a standard bioinformatic pipeline on a Hadoop-based platform. Wall-clock time for complete assembly differed by 52.9% (95% CI: 27.5-78.2 for E.coli and 53.5% (95% CI: 34.4-72.6 for human genome, with GCE being more efficient than EMR. The cost of running this experiment on EMR and GCE differed significantly, with the costs on EMR being 257.3% (95% CI: 211.5-303.1 and 173.9% (95% CI: 134.6-213.1 more expensive for E.coli and human assemblies respectively. Thus, GCE was found to outperform EMR both in terms of cost and wall-clock time. Our findings confirm that cloud computing is an efficient and potentially cost-effective alternative for analysis of large genomic datasets. In addition to releasing our cost-effectiveness comparison, we present available ready-to-use scripts for establishing Hadoop instances with Ganglia monitoring on EC2 or GCE.

  10. The Clean Energy Manufacturing Analysis Center (CEMAC): Providing Analysis and Insights on Clean Technology Manufacturing

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, Nicholi S [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2017-09-28

    The U.S. Department of Energy's Clean Energy Manufacturing Analysis Center (CEMAC) provides objective analysis and up-to-date data on global supply chains and manufacturing of clean energy technologies. Policymakers and industry leaders seek CEMAC insights to inform choices to promote economic growth and the transition to a clean energy economy.

  11. Challenges in providing counselling to MSM in highly stigmatized contexts: results of a qualitative study from Kenya.

    Directory of Open Access Journals (Sweden)

    Miriam Taegtmeyer

    Full Text Available The role of men who have sex with men (MSM in the African HIV epidemic is gaining recognition yet capacity to address the HIV prevention needs of this group is limited. HIV testing and counselling is not only a critical entry point for biomedical HIV prevention interventions, such as pre-exposure prophylaxis, rectal microbicides and early treatment initiation, but is also an opportunity for focused risk reduction counselling that can support individuals living in difficult circumstances. For prevention efforts to succeed, however, MSM need to access services and they will only do so if these are non-judgmental, informative, focused on their needs, and of clear benefit. This study aimed to understand Kenyan providers' attitudes towards and experiences with counselling MSM in a research clinic targeting this group for HIV prevention. We used in-depth interviews to explore values, attitudes and cognitive and social constructs of 13 counsellors and 3 clinicians providing services to MSM at this clinic. Service providers felt that despite their growing experience, more targeted training would have been helpful to improve their effectiveness in MSM-specific risk reduction counselling. They wanted greater familiarity with MSM in Kenya to better understand the root causes of MSM risk-taking (e.g., poverty, sex work, substance abuse, misconceptions about transmission, stigma, and sexual desire and felt frustrated at the perceived intractability of some of their clients' issues. In addition, they identified training needs on how to question men about specific risk behaviours, improved strategies for negotiating risk reduction with counselling clients, and improved support supervision from senior counsellors. This paper describes the themes arising from these interviews and makes practical recommendations on training and support supervision systems for nascent MSM HIV prevention programmes in Africa.

  12. Challenges in providing counselling to MSM in highly stigmatized contexts: results of a qualitative study from Kenya.

    Science.gov (United States)

    Taegtmeyer, Miriam; Davies, Alun; Mwangome, Mary; van der Elst, Elisabeth M; Graham, Susan M; Price, Matt A; Sanders, Eduard J

    2013-01-01

    The role of men who have sex with men (MSM) in the African HIV epidemic is gaining recognition yet capacity to address the HIV prevention needs of this group is limited. HIV testing and counselling is not only a critical entry point for biomedical HIV prevention interventions, such as pre-exposure prophylaxis, rectal microbicides and early treatment initiation, but is also an opportunity for focused risk reduction counselling that can support individuals living in difficult circumstances. For prevention efforts to succeed, however, MSM need to access services and they will only do so if these are non-judgmental, informative, focused on their needs, and of clear benefit. This study aimed to understand Kenyan providers' attitudes towards and experiences with counselling MSM in a research clinic targeting this group for HIV prevention. We used in-depth interviews to explore values, attitudes and cognitive and social constructs of 13 counsellors and 3 clinicians providing services to MSM at this clinic. Service providers felt that despite their growing experience, more targeted training would have been helpful to improve their effectiveness in MSM-specific risk reduction counselling. They wanted greater familiarity with MSM in Kenya to better understand the root causes of MSM risk-taking (e.g., poverty, sex work, substance abuse, misconceptions about transmission, stigma, and sexual desire) and felt frustrated at the perceived intractability of some of their clients' issues. In addition, they identified training needs on how to question men about specific risk behaviours, improved strategies for negotiating risk reduction with counselling clients, and improved support supervision from senior counsellors. This paper describes the themes arising from these interviews and makes practical recommendations on training and support supervision systems for nascent MSM HIV prevention programmes in Africa.

  13. Providing surgery in a war-torn context: the Médecins Sans Frontières experience in Syria.

    Science.gov (United States)

    Trelles, Miguel; Dominguez, Lynette; Tayler-Smith, Katie; Kisswani, Katrin; Zerboni, Alberto; Vandenborre, Thierry; Dallatomasina, Silvia; Rahmoun, Alaa; Ferir, Marie-Christine

    2015-01-01

    Since 2011, civil war has crippled Syria leaving much of the population without access to healthcare. Various field hospitals have been clandestinely set up to provide basic healthcare but few have been able to provide quality surgical care. In 2012, Medecins Sans Frontieres (MSF) began providing surgical care in the Jabal al-Akrad region of north-western Syria. Based on the MSF experience, we describe, for the period 5th September 2012 to 1st January 2014: a) the volume and profile of surgical cases, b) the volume and type of anaesthetic and surgical procedures performed, and c) the intraoperative mortality rate. A descriptive study using routinely collected MSF programme data. Quality surgical care was assured through strict adherence to the following minimum standards: adequate infrastructure, adequate water and sanitation provisions, availability of all essential disposables, drugs and equipment, strict adherence to hygiene requirements and universal precautions, mandatory use of sterile equipment for surgical and anaesthesia procedures, capability for blood transfusion and adequate human resources. During the study period, MSF operated on 578 new patients, of whom 57 % were male and median age was 25 years (Interquartile range: 21-32 years). Violent trauma was the most common surgical indication (n-254, 44 %), followed by obstetric emergencies (n-191, 33 %) and accidental trauma (n-59, 10 %). In total, 712 anaesthetic procedures were performed. General anaesthesia without intubation was the most common type of anaesthesia (47 % of all anaesthetics) followed by spinal anaesthesia (25 %). A total of 831 surgical procedures were performed, just over half being minor/wound care procedures and nearly one fifth, caesarean sections. There were four intra-operative deaths, giving an intra-operative mortality rate of 0.7 %. Surgical needs in a conflict-afflicted setting like Syria are high and include both combat and non-combat indications, particularly

  14. A Comparative Analysis of Fuzzy Inference Engines in Context of ...

    African Journals Online (AJOL)

    Fuzzy inference engine has found successful applications in a wide variety of fields, such as automatic control, data classification, decision analysis, expert engines, time series prediction, robotics, pattern recognition, etc. This paper presents a comparative analysis of three fuzzy inference engines, max-product, max-min ...

  15. The Context of Current Content Analysis of Gender Roles: An Introduction to a Special Issue

    Science.gov (United States)

    Popova, Lucy; Linz, Daniel G.

    2010-01-01

    The aim of this paper is to provide context for the quantitative content analyses of gender roles that are to be included in both parts of this special issue. First, a timeline of historical uses of the content analysis methodology is presented. Second, research objectives that frequently drive content analysis of gender roles are described; these include: to support feminist claims, to compare media with real life, to predict effects on audiences, and to detect effects of media producers on content. Third, previous content analyses published in Sex Roles and other gender-focused journals are reviewed and categorized in terms of medium, genre, time span, gender, and nationality. Finally, contributions of each of the articles in this special issue are outlined. PMID:20694031

  16. Using Habitat Equivalency Analysis to Assess the Cost Effectiveness of Restoration Outcomes in Four Institutional Contexts

    Science.gov (United States)

    Scemama, Pierre; Levrel, Harold

    2016-01-01

    At the national level, with a fixed amount of resources available for public investment in the restoration of biodiversity, it is difficult to prioritize alternative restoration projects. One way to do this is to assess the level of ecosystem services delivered by these projects and to compare them with their costs. The challenge is to derive a common unit of measurement for ecosystem services in order to compare projects which are carried out in different institutional contexts having different goals (application of environmental laws, management of natural reserves, etc.). This paper assesses the use of habitat equivalency analysis (HEA) as a tool to evaluate ecosystem services provided by restoration projects developed in different institutional contexts. This tool was initially developed to quantify the level of ecosystem services required to compensate for non-market impacts coming from accidental pollution in the US. In this paper, HEA is used to assess the cost effectiveness of several restoration projects in relation to different environmental policies, using case studies based in France. Four case studies were used: the creation of a market for wetlands, public acceptance of a port development project, the rehabilitation of marshes to mitigate nitrate loading to the sea, and the restoration of streams in a protected area. Our main conclusion is that HEA can provide a simple tool to clarify the objectives of restoration projects, to compare the cost and effectiveness of these projects, and to carry out trade-offs, without requiring significant amounts of human or technical resources.

  17. Efficient Context Switching for the Stack Cache: Implementation and Analysis

    DEFF Research Database (Denmark)

    Abbaspourseyedi, Sahar; Brandner, Florian; Naji, Amine

    2015-01-01

    , the analysis of the stack cache was limited to individual tasks, ignoring aspects related to multitasking. A major drawback of the original stack cache design is that, due to its simplicity, it cannot hold the data of multiple tasks at the same time. Consequently, the entire cache content needs to be saved...

  18. Listening as an Easy Skill: Analysis of a Particular Context

    Directory of Open Access Journals (Sweden)

    Marcela Morchino

    2009-06-01

    Full Text Available In this paper I want to focus on the difficulty perceived by seventh grade students in connection to listening activities in the English class, at some public schools in San Juan, Argentina. This analysis will lead to the examination of contextual factors that might act as unforeseen constraints on the language learning situation.

  19. Listening as an Easy Skill: Analysis of a Particular Context

    Science.gov (United States)

    Morchio, Marcela

    2009-01-01

    In this paper I want to focus on the difficulty perceived by seventh grade students in connection to listening activities in the English class, at some public schools in San Juan, Argentina. This analysis will lead to the examination of contextual factors that might act as unforeseen constraints on the language learning situation. (Contains 5…

  20. Human behavior analysis by means of multimodal context mining

    NARCIS (Netherlands)

    Banos Legran, Oresti; Villalonga, Claudia; Bang, Jaehun; Hur, Taeho; Kang, Donguk; Park, Sangbeom; Hyunh-The, Thien; Le-Ba, Vui; Amin, Muhammad Bilal; Razzaq, Muhammad Asif; Ali Khan, Wajahat; Hong, Choong Seon; Lee, Sungyoung

    2016-01-01

    There is sufficient evidence proving the impact that negative lifestyle choices have on people’s health and wellness. Changing unhealthy behaviours requires raising people’s self-awareness and also providing healthcare experts with a thorough and continuous description of the user’s conduct. Several

  1. Neighborhood Context and Police Vigor: A Multilevel Analysis

    Science.gov (United States)

    Sobol, James J.; Wu, Yuning; Sun, Ivan Y.

    2013-01-01

    This study provides a partial test of Klinger's ecological theory of police behavior using hierarchical linear modeling on 1,677 suspects who had encounters with police within 24 beats. The current study used data from four sources originally collected by the Project on Policing Neighborhoods (POPN), including systematic social observation,…

  2. RUINS AND URBAN CONTEXT: ANALYSIS TOWARDS CONSERVATION AND ENHANCEMENT

    Directory of Open Access Journals (Sweden)

    E. Romeo

    2013-07-01

    Full Text Available The paper presents the results of a study of classics theatres and amphitheatres in Europe and in the Mediterranean basin. The analysis started from the mapping of the Greek and Roman cities and has been focused in particular to the study of the transformations of these cities from the Middle Age to today, carried out through cartographic surveys, archival investigations and direct analysis. This process has led to understanding the different kinds of reuse that the theaters and amphitheatres have undergone throughout the centuries. Then, by comparing the historical city maps to the current ones (e.g. the maps of urban land registers, the archaeological traces of theatres and amphitheatres still incorporated in the current urban buildings have been located. Finally, a survey of the current situation has allowed identifying the material consistency and morphological characterization of these ancient artifacts. The process led to the proposal of strategies for the conservation and enhancement of ancient entertainment buildings, that respect both the archeological elements and the successive stratification that characterize today our historical cities.

  3. School violence: An analysis from different interaction contexts

    Directory of Open Access Journals (Sweden)

    Rosa María Varela Garay

    2013-04-01

    Full Text Available The aim of the current study was to analyze the differences between adolescents scoring high and low on school violence in the following areas: individual (self-esteem, loneliness, satisfaction with life, and empathy; family (family climate, communication with father and mother; academic (classroom climate, attitudes toward authority, and sociometric status; and community (community involvement, community participation, social support from formal systems, and social support from informal systems. Differences in these relationships between boys and girls scoring high on school violence were also examined. Participants in the study were 1723 adolescents, aged 12 to 18 years old, in four secondary schools. Multivariate and univariate analysis of variance were performed. Results showed that adolescents with high levels of school violence scored higher on loneliness, depressive symptomatology, offensive and avoidance communication with father and mother, family conflict, and attitude towards transgression, as compared to adolescents with low levels of school violence. Furthermore, girls scoring high on school violence reported higher scores on academic self-esteem, empathy, and sociometric status, and lower scores on open communication with father and community participation, as compared to boys scoring high in school violence. Finally, these results and their practical implications are discussed.

  4. Concept analysis of dietary biculturalism in Filipino immigrants within the context of cardiovascular risk.

    Science.gov (United States)

    Serafica, Reimund; Knurick, Jessica; Morris, Brendan Tran

    2018-04-01

    Dietary biculturalism is an emerging phenomenon among the Filipino immigrant population. Determining the concept of dietary biculturalism on this specific population will unravel some of the obscurities of emerging dietary patterns within the context of cardiovascular risk. The purpose of this article is to provide a concept analysis of dietary biculturalism within the health context of cardiovascular risk using Walker and Avant's method as an organizing framework. A detailed literature review was performed on the basis of population specificity (Filipinos) use of dietary patterns as variable and theoretical literary models of acculturation. The generalizability of published research on this issue is problematic since researchers have not addressed the unhealthy traditional foods component that one may consume in addition to the Western foods. Nurse researchers should focus on the detrimental effects of unhealthy traditional foods that may be relevant in explaining some of the cardiovascular risk factors affecting this population. Nurses and practitioners should take care to query not only about the frequency of ethnic food consumption, but also types, and amounts among their Filipino patients. © 2017 Wiley Periodicals, Inc.

  5. Facial Expressivity at 4 Months: A Context by Expression Analysis.

    Science.gov (United States)

    Bennett, David S; Bendersky, Margaret; Lewis, Michael

    2002-01-01

    The specificity predicted by differential emotions theory (DET) for early facial expressions in response to 5 different eliciting situations was studied in a sample of 4-month-old infants (n = 150). Infants were videotaped during tickle, sour taste, jack-in-the-box, arm restraint, and masked-stranger situations and their expressions were coded second by second. Infants showed a variety of facial expressions in each situation; however, more infants exhibited positive (joy and surprise) than negative expressions (anger, disgust, fear, and sadness) across all situations except sour taste. Consistent with DET-predicted specificity, joy expressions were the most common in response to tickling, and were less common in response to other situations. Surprise expressions were the most common in response to the jack-in-the-box, as predicted, but also were the most common in response to the arm restraint and masked-stranger situations, indicating a lack of specificity. No evidence of predicted specificity was found for anger, disgust, fear, and sadness expressions. Evidence of individual differences in expressivity within situations, as well as stability in the pattern across situations, underscores the need to examine both child and contextual factors in studying emotional development. The results provide little support for the DET postulate of situational specificity and suggest that a synthesis of differential emotions and dynamic systems theories of emotional expression should be considered.

  6. Context Sensing System Analysis for Privacy Preservation Based on Game Theory.

    Science.gov (United States)

    Wang, Shengling; Li, Luyun; Sun, Weiman; Guo, Junqi; Bie, Rongfang; Lin, Kai

    2017-02-10

    In a context sensing system in which a sensor-equipped mobile phone runs an unreliable context-aware application, the application can infer the user's contexts, based on which it provides personalized services. However, the application may sell the user's contexts to some malicious adversaries to earn extra profits, which will hinder its widespread use. In the real world, the actions of the user, the application and the adversary in the context sensing system affect each other, so that their payoffs are constrained mutually. To figure out under which conditions they behave well (the user releases, the application does not leak and the adversary does not retrieve the context), we take advantage of game theory to analyze the context sensing system. We use the extensive form game and the repeated game, respectively, to analyze two typical scenarios, single interaction and multiple interaction among three players, from which Nash equilibriums and cooperation conditions are obtained. Our results show that the reputation mechanism for the context-sensing system in the former scenario is crucial to privacy preservation, so is the extent to which the participants are concerned about future payoffs in the latter one.

  7. Food recognition and recipe analysis: integrating visual content, context and external knowledge

    OpenAIRE

    Herranz, Luis; Min, Weiqing; Jiang, Shuqiang

    2018-01-01

    The central role of food in our individual and social life, combined with recent technological advances, has motivated a growing interest in applications that help to better monitor dietary habits as well as the exploration and retrieval of food-related information. We review how visual content, context and external knowledge can be integrated effectively into food-oriented applications, with special focus on recipe analysis and retrieval, food recommendation, and the restaurant context as em...

  8. Remote sensing analysis for flood risk management in urban sprawl contexts

    Directory of Open Access Journals (Sweden)

    Francesca Franci

    2015-07-01

    Full Text Available Remote sensing can play a key role in risk assessment and management, especially when several concurrent factors coexist, such as a predisposition to natural disasters and the urban sprawl, spreading over highly vulnerable areas. In this context, multitemporal analysis can provide decision-makers with tools and information to reduce the impacts of disasters (e.g. flooding and to encourage a sustainable development. The present work focuses on the employment of multispectral satellite imagery to produce multitemporal land use/cover maps for the city of Dhaka, which is subject to frequent flooding events. In particular, the evaluation of the urban growth, the analysis of the annual dynamics of flooding and the study of the 2004 catastrophic event were performed. For the change-detection procedure, Landsat images were used. These images allow the quantification of the very rapid growth of the metropolis, with an increase in built-up areas from 75 to 111 km2. The image of 2009 showed that an ordinary flood affects about 115 km2 (on a studied area of 591 km2. On the other hand, the analysis of the 2004 extreme flooding event, performed on a wider area, showed that the affected lands added up to 750 km2 (on about 3845 km2.

  9. Voice hearing within the context of hearers' social worlds: an interpretative phenomenological analysis.

    Science.gov (United States)

    Mawson, Amy; Berry, Katherine; Murray, Craig; Hayward, Mark

    2011-09-01

    Research has found relational qualities of power and intimacy to exist within hearer-voice interactions. The present study aimed to provide a deeper understanding of the interpersonal context of voice hearing by exploring participants' relationships with their voices and other people in their lives. This research was designed in consultation with service users and employed a qualitative, phenomenological, and idiographic design using semi-structured interviews. Ten participants, recruited via mental health services, and who reported hearing voices in the previous week, completed the interviews. These were transcribed verbatim and analysed using interpretative phenomenological analysis. Five themes resulted from the analysis. Theme 1: 'person and voice' demonstrated that participants' voices often reflected the identity, but not always the quality of social acquaintances. Theme 2: 'voices changing and confirming relationship with the self' explored the impact of voice hearing in producing an inferior sense-of-self in comparison to others. Theme 3: 'a battle for control' centred on issues of control and a dilemma of independence within voice relationships. Theme 4: 'friendships facilitating the ability to cope' and theme 5: 'voices creating distance in social relationships' explored experiences of social relationships within the context of voice hearing, and highlighted the impact of social isolation for voice hearers. The study demonstrated the potential role of qualitative research in developing theories of voice hearing. It extended previous research by highlighting the interface between voices and the social world of the hearer, including reciprocal influences of social relationships on voices and coping. Improving voice hearers' sense-of-self may be a key factor in reducing the distress caused by voices. ©2010 The British Psychological Society.

  10. A concept analysis of the term migrant women in the context of pregnancy.

    Science.gov (United States)

    Balaam, Marie-Clare; Haith-Cooper, Melanie; Pařízková, Alena; Weckend, Marina Joanna; Fleming, Valerie; Roosalu, Triin; Vržina, Sanja Špoljar

    2017-12-01

    This paper explores the concept of migrant women as used in European healthcare literature in context of pregnancy to provide a clearer understanding of the concept for use in research and service delivery. Walker and Avant's method of concept analysis. The literature demonstrates ambiguity around the concept; most papers do not provide an explicit or detailed definition of the concept. They include the basic idea that women have moved from an identifiable region/country to the country in which the research is undertaken but fail to acknowledge adequately the heterogeneity of migrant women. The paper provides a definition of the concept as a descriptive theory and argues that research must include a clear definition of the migrant specific demographics of the women. This should include country/region of origin and host, status within the legal system of host country, type of migration experience, and length of residence. There is a need for a more systematic conceptualization of the idea of migrant women within European literature related to pregnancy experiences and outcomes to reflect the heterogeneity of this concept. To this end, the schema suggested in this paper should be adopted in future research. © 2017 The Authors. International Journal of Nursing Practice Published by John Wiley & Sons Australia, Ltd.

  11. Confirmatory factor analysis of the Multi-dimensional Emotional Empathy Scale in the South African context

    Directory of Open Access Journals (Sweden)

    Chantal Olckers

    2010-11-01

    Full Text Available Orientation: Empathy is a core competency in aiding individuals to address the challenges of social living. An indicator of emotional intelligence, it is useful in a globalising and cosmopolitan world. Moreover, managing staff, stakeholders and conflict in many social settings relies on communicative skills, of which empathy forms a large part. Empathy plays a pivotal role in negotiating, persuading and influencing behaviour. The skill of being able to empathise thus enables the possessor to attune to the needs of clients and employees and provides opportunities to become responsive to these needs. Research purpose: This study attempted to determine the construct validity of the Multi-dimensional Emotional Empathy Scale within the South African context. Motivation for the study: In South Africa, a large number of psychometrical instruments have been adopted directly from abroad. Studies determining the construct validity of several of these imported instruments, however, have shown that these instruments are not suited for use in the South African context. Research design, approach and method: The study was based on a quantitative research method with a survey design. A convenience sample of 212 respondents completed the Multi-dimensional Emotional Empathy Scale. The constructs explored were Suffering, Positive Sharing, Responsive Crying, Emotional Attention, a Feel for Others and Emotional Contagion. The statistical procedure used was a confirmatory factor analysis. Main findings: The study showed that, from a South African perspective, the Multi-dimensional Emotional Empathy Scale lacks sufficient construct validity. Practical/managerial implications: Further refinement of the model would provide valuable information that would aid people to be more appreciative of individual contributions, to meet client needs and to understand the motivations of others. Contribution/value-add: From a South African perspective, the findings of this study are

  12. Environmental context-dependent memory: a review and meta-analysis.

    Science.gov (United States)

    Smith, S M; Vela, E

    2001-06-01

    To address questions about human memory's dependence on the coincidental environmental contexts in which events occur, we review studies of incidental environmental context-dependent memory in humans and report a meta-analysis. Our theoretical approach to the issue stems from Glenberg's (1997) contention that introspective thought (e.g., remembering, conceptualizing) requires cognitive resources normally used to represent the immediate environment. We propose that if tasks encourage processing of noncontextual information (i.e., introspective thought) at input and/or at test, then both learning and memory will be less dependent on the ambient environmental contexts in which those activities occur. The meta-analysis showed that across all studies, environmental context effects were reliable, and furthermore, that the use of noncontextual cues during learning (overshadowing) and at test (outshining), as well as mental reinstatement of appropriate context cues at test, all reduce the effect of environmental manipulations. We conclude that environmental context-dependent memory effects are less likely to occur under conditions in which the immediate environment is likely to be suppressed.

  13. The Net Neutrality Debate: Analysis of economic implications of net neutrality on internet service providers, content providers and internet users

    OpenAIRE

    Møinichen, Jørgen

    2014-01-01

    This thesis studies the economic implications of a transition from a neutral to a non-neutral network. A mathematical model with an end to end ecosystem is developed, which includes a backbone internet service provider that provides connectivity for the content providers. The model also includes internet users that pay an access internet service provider for connectivity to interact with the content providers, advertisers that pay the content providers, and access internet service providers t...

  14. A vision-based system for intelligent monitoring: human behaviour analysis and privacy by context.

    Science.gov (United States)

    Chaaraoui, Alexandros Andre; Padilla-López, José Ramón; Ferrández-Pastor, Francisco Javier; Nieto-Hidalgo, Mario; Flórez-Revuelta, Francisco

    2014-05-20

    Due to progress and demographic change, society is facing a crucial challenge related to increased life expectancy and a higher number of people in situations of dependency. As a consequence, there exists a significant demand for support systems for personal autonomy. This article outlines the vision@home project, whose goal is to extend independent living at home for elderly and impaired people, providing care and safety services by means of vision-based monitoring. Different kinds of ambient-assisted living services are supported, from the detection of home accidents, to telecare services. In this contribution, the specification of the system is presented, and novel contributions are made regarding human behaviour analysis and privacy protection. By means of a multi-view setup of cameras, people's behaviour is recognised based on human action recognition. For this purpose, a weighted feature fusion scheme is proposed to learn from multiple views. In order to protect the right to privacy of the inhabitants when a remote connection occurs, a privacy-by-context method is proposed. The experimental results of the behaviour recognition method show an outstanding performance, as well as support for multi-view scenarios and real-time execution, which are required in order to provide the proposed services.

  15. A Vision-Based System for Intelligent Monitoring: Human Behaviour Analysis and Privacy by Context

    Directory of Open Access Journals (Sweden)

    Alexandros Andre Chaaraoui

    2014-05-01

    Full Text Available Due to progress and demographic change, society is facing a crucial challenge related to increased life expectancy and a higher number of people in situations of dependency. As a consequence, there exists a significant demand for support systems for personal autonomy. This article outlines the vision@home project, whose goal is to extend independent living at home for elderly and impaired people, providing care and safety services by means of vision-based monitoring. Different kinds of ambient-assisted living services are supported, from the detection of home accidents, to telecare services. In this contribution, the specification of the system is presented, and novel contributions are made regarding human behaviour analysis and privacy protection. By means of a multi-view setup of cameras, people’s behaviour is recognised based on human action recognition. For this purpose, a weighted feature fusion scheme is proposed to learn from multiple views. In order to protect the right to privacy of the inhabitants when a remote connection occurs, a privacy-by-context method is proposed. The experimental results of the behaviour recognition method show an outstanding performance, as well as support for multi-view scenarios and real-time execution, which are required in order to provide the proposed services.

  16. Multidimensional proteomics analysis of amniotic fluid to provide insight into the mechanisms of idiopathic preterm birth.

    Directory of Open Access Journals (Sweden)

    Irina A Buhimschi

    2008-04-01

    Full Text Available Though recent advancement in proteomics has provided a novel perspective on several distinct pathogenetic mechanisms leading to preterm birth (inflammation, bleeding, the etiology of most preterm births still remains elusive. We conducted a multidimensional proteomic analysis of the amniotic fluid to identify pathways related to preterm birth in the absence of inflammation or bleeding.A proteomic fingerprint was generated from fresh amniotic fluid using surface-enhanced laser desorbtion ionization time of flight (SELDI-TOF mass spectrometry in a total of 286 consecutive samples retrieved from women who presented with signs or symptoms of preterm labor or preterm premature rupture of the membranes. Inflammation and/or bleeding proteomic patterns were detected in 32% (92/286 of the SELDI tracings. In the remaining tracings, a hierarchical algorithm was applied based on descriptors quantifying similarity/dissimilarity among proteomic fingerprints. This allowed identification of a novel profile (Q-profile based on the presence of 5 SELDI peaks in the 10-12.5 kDa mass area. Women displaying the Q-profile (mean+/-SD, gestational age: 25+/-4 weeks, n = 40 were more likely to deliver preterm despite expectant management in the context of intact membranes and normal amniotic fluid clinical results. Utilizing identification-centered proteomics techniques (fluorescence two-dimensional differential gel electrophoresis, robotic tryptic digestion and mass spectrometry coupled with Protein ANalysis THrough Evolutionary Relationships (PANTHER ontological classifications, we determined that in amniotic fluids with Q-profile the differentially expressed proteins are primarily involved in non-inflammatory biological processes such as protein metabolism, signal transduction and transport.Proteomic profiling of amniotic fluid coupled with non-hierarchical bioinformatics algorithms identified a subgroup of patients at risk for preterm birth in the absence of intra

  17. 'I am treated well if I adhere to my HIV medication': putting patient-provider interactions in context through insights from qualitative research in five sub-Saharan African countries.

    Science.gov (United States)

    Ondenge, Ken; Renju, Jenny; Bonnington, Oliver; Moshabela, Mosa; Wamoyi, Joyce; Nyamukapa, Constance; Seeley, Janet; Wringe, Alison; Skovdal, Morten

    2017-07-01

    The nature of patient-provider interactions and communication is widely documented to significantly impact on patient experiences, treatment adherence and health outcomes. Yet little is known about the broader contextual factors and dynamics that shape patient-provider interactions in high HIV prevalence and limited-resource settings. Drawing on qualitative research from five sub-Saharan African countries, we seek to unpack local dynamics that serve to hinder or facilitate productive patient-provider interactions. This qualitative study, conducted in Kisumu (Kenya), Kisesa (Tanzania), Manicaland (Zimbabwe), Karonga (Malawi) and uMkhanyakude (South Africa), draws upon 278 in-depth interviews with purposively sampled people living with HIV with different diagnosis and treatment histories, 29 family members of people who died due to HIV and 38 HIV healthcare workers. Data were collected using topic guides that explored patient testing and antiretroviral therapy treatment journeys. Thematic analysis was conducted, aided by NVivo V.8.0 software. Our analysis revealed an array of inter-related contextual factors and power dynamics shaping patient-provider interactions. These included (1) participants' perceptions of roles and identities of 'self' and 'other'; (2) conformity or resistance to the 'rules of HIV service engagement' and a 'patient-persona'; (3) the influence of significant others' views on service provision; and (4) resources in health services. We observed that these four factors/dynamics were located in the wider context of conceptualisations of power, autonomy and structure. Patient-provider interaction is complex, multidimensional and deeply embedded in wider social dynamics. Multiple contextual domains shape patient-provider interactions in the context of HIV in sub-Saharan Africa. Interventions to improve patient experiences and treatment adherence through enhanced interactions need to go beyond the existing focus on patient-provider communication

  18. Psychometric analysis of export market orientation measurement scale in Croatian SME exporters’ context

    Directory of Open Access Journals (Sweden)

    Dario Miočević

    2009-07-01

    Full Text Available Market orientation is a vital construct of the marketing concept. Although different conceptualization approaches to market orientation have been discussed by literature so far, a common denominator is its interdependence with business performance. Increasing globalization trends affect both the markets’ convergence and competition. Consequently, focusing on market orientation within an international context is of utmost importance. Export market orientation (EMO is relatively new concept, which puts market orientation into the international context. Since export is a dominant international entry strategy in the Croatian economy which comprises mostly SMEs, it is crucial to investigate the importance of the EMO in the Croatian SME context. Determining an appropriate measurement scale of the EMO to be applied in various national research contexts leading to generalization represents a challenge for marketing academicians. The paper aims to find out whether the EMO construct and measurement scale can be applied within the Croatian SME context. The authors have used the exploratory and the confirmatory factor analysis to determine the psychometric properties of the EMO scale. The results of psychometric assessment of the EMO scale confirm its dimensionability, reliability, validity and applicability in the Croatian SME context. Results clearly indicate the necessity of pursuing EMO activities in order to achieve a high level of export performance.

  19. EQUILIBRIUM ANALYSIS OF FINANCIAL COMPANY BASED ON INFORMATION PROVIDED BY THE BALANCE SHEET

    Directory of Open Access Journals (Sweden)

    Ștefăniță ȘUȘU

    2014-06-01

    Full Text Available This article highlights the importance of indicators (as net working capital, working capital requirements and net cash by means of which it is considered in the context of financial balances capitalization information released by the balance sheet of an entity tourist profile. Theoretical concepts presented in a logical sequence are combined with the practical example transposed Turism Covasna company. The results of the analysis are interpreted while trying to formulate solutions to the economic and financial viability of the entity.

  20. Testing-Context Analysis: Assessment Is Just Another Part of Language Curriculum Development

    Science.gov (United States)

    Brown, James Dean

    2008-01-01

    In keeping with the theme of the International Language Testing Association/Language Testing Research Colloquium Conference in 2008, "Focusing on the Core: Justifying the Use of Language Assessments to Stakeholders," I define "stakeholder-friendly tests," "defensible testing," and "testing-context analysis."…

  1. Comparative Analysis of Pedagogical Technologies in the Context of Future Agrarians' Multicultural Education in the USA

    Science.gov (United States)

    Kravets, Ruslan

    2015-01-01

    In the article the comparative analysis of pedagogical technologies in the USA has been carried out in the context of future agrarians' multicultural education. The essence of traditional and innovative pedagogical technologies and the peculiarities of their realization at higher educational establishments have been viewed. The expediency of…

  2. Patterns of Change in Willingness to Communicate in Public Speaking Contexts: A Latent Growth Modeling Analysis

    Science.gov (United States)

    Hodis, Georgeta M.; Bardhan, Nilanjana R.; Hodis, Flaviu A.

    2010-01-01

    This study offers a comprehensive analysis of change in willingness to communicate (WTC) in public speaking contexts (i.e., PS-WTC). The proposed conceptualization of change was tested using longitudinal data collected from a sample of 706 undergraduate students enrolled in an introductory communication course in a US university. Results of latent…

  3. An Empirical Analysis of Chinese College Learners' Obstacles to MOOC Learning in an English Context

    Science.gov (United States)

    Liu, Liangxing

    2017-01-01

    This article reports a study applying an exploratory factor analysis to discovering the underlying factor structure of Chinese college students' obstacles to learning MOOC in an English context. Seven obstacle factors are identified: 1. academic and language skills; 2. internet skills; 3. course instruction/management; 4. learning motivations; 5.…

  4. Government Ownership and the Capital Structure of firms : Empirical Analysis of an Institutional Context from China

    NARCIS (Netherlands)

    Huang, Xiaohong; Kabir, Rezaul; Zhang, Lingling

    2018-01-01

    Institutional context influences corporate financing behavior of firms, and emerging economies provide interesting scenarios to investigate this phenomenon. In this study, we focus on the capital structure decision of Chinese listed firms following the Split-Share Reform of 2005 that allowed

  5. Siberian Regional Identity in the Context of Historical Consciousness (Content Analysis of Tomsk Regional Media

    Directory of Open Access Journals (Sweden)

    A V Bocharov

    2011-12-01

    Full Text Available The article presents a model to study the Siberian regional identity in the context of historical consciousness, as well as the results of its practical application in the content analysis of the publications by the Tomsk regional media. On the basis of the content analysis procedures the author demonstrates how, through historical memory, the regional identity is formed and manifested in the regional media in various spheres of society.

  6. ANALYSIS DYNAMICS VALUES FORMULATION IN THE CONTEXT OF THE BUSINESS ORGANIZATION’ S MISSION

    Directory of Open Access Journals (Sweden)

    Marius Costel Esi

    2015-02-01

    Full Text Available The economic activity goals reveal a number of aspects which express the need for re-evaluating the way in which the dynamics analysis values may be correlated with the wording business mission. Under these conditions, managerial undertaken strategies at the level of business may be validated in so far as they reveal purpose/ objectives assumed/ undertaken by decision makers (particularly top-managers. Moreover, compliance with eligibility criteria according to which management strategies are reflected, should be aimed at in our opinion improving decision-making process. But such a decision-making process involves an understanding of the judicious economic actors/ labor with regard to the way in which it is possible to analyze the dynamics values in relation to formulation  of  business organization's mission. In these circumstances, a first objective of this research is analysis dynamics values in the context of formulation of business mission. In this way, by this approach, we strive to show you those conditionings that make it possible formulation of business mission in relation to organizational culture.  On the other hand, a second objective that we have in view is given of the way in which is to bring about the process of defining and statement of organizational mission, a process linked to the size of axiological mission statement of business organization. This status as a matter of fact, in the light of the analysis we take into account,  a business model in which the objectives, strategies, organization mission business become materialized in so far as that contextuality  venture is validated in relation to socio-economic prospects. Therefore, the existence of phenomena such as social and economic situation involves a series of connections between different levels of displacing of the organization of business which provides, in fact, its legitimacy

  7. Exploring factors that influence work analysis data: A meta-analysis of design choices, purposes, and organizational context.

    Science.gov (United States)

    DuVernet, Amy M; Dierdorff, Erich C; Wilson, Mark A

    2015-09-01

    Work analysis is fundamental to designing effective human resource systems. The current investigation extends previous research by identifying the differential effects of common design decisions, purposes, and organizational contexts on the data generated by work analyses. The effects of 19 distinct factors that span choices of descriptor, collection method, rating scale, and data source, as well as project purpose and organizational features, are explored. Meta-analytic results cumulated from 205 articles indicate that many of these variables hold significant consequences for work analysis data. Factors pertaining to descriptor choice, collection method, rating scale, and the purpose for conducting the work analysis each showed strong associations with work analysis data. The source of the work analysis information and organizational context in which it was conducted displayed fewer relationships. Findings can be used to inform choices work analysts make about methodology and postcollection evaluations of work analysis information. (c) 2015 APA, all rights reserved).

  8. Exploring the context in which different close-to-community sexual and reproductive health service providers operate in Bangladesh: a qualitative study.

    Science.gov (United States)

    Mahmud, Ilias; Chowdhury, Sadia; Siddiqi, Bulbul Ashraf; Theobald, Sally; Ormel, Hermen; Biswas, Salauddin; Jahangir, Yamin Tauseef; Sarker, Malabika; Rashid, Sabina Faiz

    2015-09-01

    A range of formal and informal close-to-community (CTC) health service providers operate in an increasingly urbanized Bangladesh. Informal CTC health service providers play a key role in Bangladesh's pluralistic health system, yet the reasons for their popularity and their interactions with formal providers and the community are poorly understood. This paper aims to understand the factors shaping poor urban and rural women's choice of service provider for their sexual and reproductive health (SRH)-related problems and the interrelationships between these providers and communities. Building this evidence base is important, as the number and range of CTC providers continue to expand in both urban slums and rural communities in Bangladesh. This has implications for policy and future programme interventions addressing the poor women's SRH needs. Data was generated through 24 in-depth interviews with menstrual regulation clients, 12 focus group discussions with married men and women in communities and 24 semi-structured interviews with formal and informal CTC SRH service providers. Data was collected between July and September 2013 from three urban slums and one rural site in Dhaka and Sylhet, Bangladesh. Atlas.ti software was used to manage data analysis and coding, and a thematic analysis was undertaken. Poor women living in urban slums and rural areas visit a diverse range of CTC providers for SRH-related problems. Key factors influencing their choice of provider include the following: availability, accessibility, expenses and perceived quality of care, the latter being shaped by notions of trust, respect and familiarity. Informal providers are usually the first point of contact even for those clients who subsequently access SRH services from formal providers. Despite existing informal interactions between both types of providers and a shared understanding that this can be beneficial for clients, there is no effective link or partnership between these providers for

  9. A stochastic context free grammar based framework for analysis of protein sequences

    Directory of Open Access Journals (Sweden)

    Nebel Jean-Christophe

    2009-10-01

    Full Text Available Abstract Background In the last decade, there have been many applications of formal language theory in bioinformatics such as RNA structure prediction and detection of patterns in DNA. However, in the field of proteomics, the size of the protein alphabet and the complexity of relationship between amino acids have mainly limited the application of formal language theory to the production of grammars whose expressive power is not higher than stochastic regular grammars. However, these grammars, like other state of the art methods, cannot cover any higher-order dependencies such as nested and crossing relationships that are common in proteins. In order to overcome some of these limitations, we propose a Stochastic Context Free Grammar based framework for the analysis of protein sequences where grammars are induced using a genetic algorithm. Results This framework was implemented in a system aiming at the production of binding site descriptors. These descriptors not only allow detection of protein regions that are involved in these sites, but also provide insight in their structure. Grammars were induced using quantitative properties of amino acids to deal with the size of the protein alphabet. Moreover, we imposed some structural constraints on grammars to reduce the extent of the rule search space. Finally, grammars based on different properties were combined to convey as much information as possible. Evaluation was performed on sites of various sizes and complexity described either by PROSITE patterns, domain profiles or a set of patterns. Results show the produced binding site descriptors are human-readable and, hence, highlight biologically meaningful features. Moreover, they achieve good accuracy in both annotation and detection. In addition, findings suggest that, unlike current state-of-the-art methods, our system may be particularly suited to deal with patterns shared by non-homologous proteins. Conclusion A new Stochastic Context Free

  10. Towards Context-Aware Search and Analysis on Social Media Data

    DEFF Research Database (Denmark)

    Derczynski, Leon; Yang, Bin; Jensen, Christian S.

    2013-01-01

    Social media has changed the way we communicate. Social media data capture our social interactions and utterances in machine readable format. Searching and analysing massive and frequently updated social media data brings significant and diverse rewards across many different application domains......, from politics and business to social science and epidemiology. A notable proportion of social media data comes with explicit or implicit spatial annotations, and almost all social media data has temporal metadata. We view social media data as a constant stream of data points, each containing text...... with spatial and temporal contexts. We identify challenges relevant to each context, which we intend to subject to context aware querying and analysis, specifically including longitudinal analyses on social media archives, spatial keyword search, local intent search, and spatio-temporal intent search. Finally...

  11. SERVICES MARKETING WITHIN BUSINESS-TO-BUSINESS CONTEXT: A CONTENT ANALYSIS OF 1996 – 2014 PERIOD

    Directory of Open Access Journals (Sweden)

    Ceren Akman Biyik

    2017-06-01

    Full Text Available The aim of the study is to conduct a content analysis of services marketing within business-tobusiness context that were published between years 1996-2014. A qualitative approach was used and content analysis was conducted on 71 articles from 24 journals in this study. Firstly, thematic investigation was conducted, and then coding process was completed. According to the results of content analysis, top research topics are determined based on services marketing and business-to-business context. The findings of the study also showed the least studied topics and shed light on new research areas to the researchers in the field of services marketing and business-to-business.

  12. Messages on pregnancy and family planning that providers give women living with HIV in the context of a Positive Health, Dignity, and Prevention intervention in Mozambique

    Directory of Open Access Journals (Sweden)

    Hilliard S

    2014-12-01

    Full Text Available Starr Hilliard, Sarah A Gutin, Carol Dawson Rose Department of Community Health Systems, School of Nursing, University of California at San Francisco, San Francisco, CA, USA Background: Family planning is an important HIV prevention tool for women living with HIV (WLHIV. In Mozambique, the prevalence of HIV among women of reproductive age is 13.1% and the average fertility rate is high. However, family planning and reproductive health for WLHIV are under-addressed in Mozambique. This study explores provider descriptions of reproductive health messages in order to identify possible barriers and facilitators to successfully addressing family planning and pregnancy concerns of WLHIV. Methods: In 2006, a Positive Health, Dignity, and Prevention program was introduced in Mozambique focused on training health care providers to work with patients to reduce their transmission risks. Providers received training on multiple components, including family planning and prevention of mother-to-child transmission (PMTCT. In-depth interviews were conducted with 31 providers who participated in the training in five rural clinics in three provinces. Data were analyzed using qualitative content analysis. Results: Analysis showed that providers' clinical messages on family planning, pregnancy, and PMTCT for WLHIV could be arranged along a continuum. Provider statements ranged from saying that WLHIV should not become pregnant and condoms are the only valid form of family planning for WLHIV, to suggesting that WLHIV can have safe pregnancies. Conclusion: These data indicate that many providers continue to believe that WLHIV should not have children and this represents a challenge for integrating family planning into the care of WLHIV. Also, not offering WLHIV a full selection of family planning methods severely limits their ability to protect themselves from unintended pregnancies and to fully exercise their reproductive rights. Responding to the reproductive health

  13. Realtime Interaction Analysis of Social Interplay in a Multimodal Musical-Sonic Interaction Context

    DEFF Research Database (Denmark)

    Hansen, Anne-Marie

    2010-01-01

    This paper presents an approach to the analysis of social interplay among users in a multimodal interaction and musical performance situation. The approach consists of a combined method of realtime sensor data analysis for the description and interpretation of player gestures and video micro......-analysis methods used to describe the interaction situation and the context in which the social interplay takes place. This combined method is used in an iterative process, where the design of interactive games with musical-sonic feedback is improved according to newly discovered understandings and interpretations...

  14. Understanding persuasion contexts in health gamification: A systematic analysis of gamified health behavior change support systems literature.

    Science.gov (United States)

    Alahäivälä, Tuomas; Oinas-Kukkonen, Harri

    2016-12-01

    Gamification is increasingly used as a design strategy when developing behavior change support systems in the healthcare domain. It is commonly agreed that understanding the contextual factors is critical for successful gamification, but systematic analyses of the persuasive contexts have been lacking so far within gamified health intervention studies. Through a persuasion context analysis of the gamified health behavior change support systems (hBCSSs) literature, we inspect how the contextual factors have been addressed in the prior gamified health BCSS studies. The implications of this study are to provide the practitioners and researchers examples of how to conduct a systematic analysis to help guide the design and research on gamified health BCSSs. The ideas derived from the analysis of the included studies will help identify potential pitfalls and shortcomings in both the research and implementations of gamified health behavior change support systems. We systematically analyzed the persuasion contexts of 15 gamified health intervention studies. According to our results, gamified hBCSSs are implemented under different facets of lifestyle change and treatments compliance, and use a multitude of technologies and methods. We present a set of ideas and concepts to help improve endeavors in studying gamified health intervention through comprehensive understanding of the persuasive contextual factors. Future research on gamified hBCSSs should systematically compare the different combinations of contextual factors, related theories, chosen gamification strategies, and the study of outcomes to help understand how to achieve the most efficient use of gamification on the different aspects of healthcare. Analyzing the persuasion context is essential to achieve this. With the attained knowledge, those planning health interventions can choose the 'tried-and-tested' approaches for each particular situation, rather than develop solutions in an ad-hoc manner. Copyright © 2016

  15. Analysis of magnitude and duration of floods and droughts in the context of climate change

    Science.gov (United States)

    Eshetu Debele, Sisay; Bogdanowicz, Ewa; Strupczewski, Witold

    2016-04-01

    Research and scientific information are key elements of any decision-making process. There is also a strong need for tools to describe and compare in a concise way the regime of hydrological extreme events in the context of presumed climate change. To meet these demands, two complementary methods for estimating high and low-flow frequency characteristics are proposed. Both methods deal with duration and magnitude of extreme events. The first one "flow-duration-frequency" (known as QdF) has already been applied successfully to low-flow analysis, flood flows and rainfall intensity. The second one called "duration-flow-frequency" (DqF) was proposed by Strupczewski et al. in 2010 to flood frequency analysis. The two methods differ in the treatment of flow and duration. In the QdF method the duration (d-consecutive days) is a chosen fixed value and the frequency analysis concerns the annual or seasonal series of mean value of flows exceeded (in the case of floods) or non-exceeded (in the case of droughts) within d-day period. In the second method, DqF, the flows are treated as fixed thresholds and the duration of flows exceeding (floods) and non-exceeding (droughts) these thresholds are a subject of frequency analysis. The comparison of characteristics of floods and droughts in reference period and under future climate conditions for catchments studied within the CHIHE project is presented and a simple way to show the results to non-professionals and decision-makers is proposed. The work was undertaken within the project "Climate Change Impacts on Hydrological Extremes (CHIHE)", which is supported by the Norway-Poland Grants Program administered by the Norwegian Research Council. The observed time series were provided by the Institute of Meteorology and Water Management (IMGW), Poland. Strupczewski, W. G., Kochanek, K., Markiewicz, I., Bogdanowicz, E., Weglarczyk, S., & Singh V. P. (2010). On the Tails of Distributions of Annual Peak Flow. Hydrology Research, 42, 171

  16. Geographic context scanning & analysis: il Modello Di Riferimento e le Operazioni

    Directory of Open Access Journals (Sweden)

    Maurizio Rosina

    2013-12-01

    Full Text Available The aim of the article is to define a Reference Model and the operators which allow to perform the activities of Geographic ContextScanning & Analysis. The theory and methods exposed will contribute to the evolution of the framework GEOPOI 2.0, developed and delivered by Sogei and acc essed as a SaaS (Software as a Serv ice by a number of Public Administrations for your own institutional tasks.

  17. The role of private health providers in HIV testing: analysis of data from 18 countries.

    Science.gov (United States)

    Johnson, Doug; Cheng, Xi

    2014-05-12

    HIV testing and counseling is a critical component of the overall response to the HIV epidemic in low and middle income countries. To date, little attention has been paid to the role of private for-profit providers in HIV testing. We use data from Demographic and Health Surveys and AIDS Indicators Surveys to explore the extent to which this sector provides HIV testing in 18 developing countries. We find that use of the private sector for HIV testing varies significantly by country, with private for-profit providers playing a significant role in some countries and a relatively minor one in others. At the country level, use of private providers for HIV testing is correlated with use of private providers for other health services yet, in many countries, significant differences between use of the private sector for HIV testing and other services exist. Within countries, we find that wealth is strongly associated with use of the private sector for HIV testing in most countries, but the relative socio-economic profile of clients who receive an HIV test from a private provider varies considerably across countries. On the one measure of quality to which we have access, reported adherence to antenatal care testing guidelines, there are no statistically significant differences in performance between public and private for-profit providers in most countries after controlling for wealth. These results suggest that strategies for supervising and engaging private health providers with regard to HIV testing should be country specific and take into account local context.

  18. An analysis of narratives to identify critical thinking contexts in psychiatric clinical practice.

    Science.gov (United States)

    Mun, Mi Suk

    2010-02-01

    The development of students' critical thinking abilities is one of the greatest challenges facing contemporary nursing educators. Nursing educators should know about what kind of contents or situations need critical thinking. The research was undertaken to identify the critical thinking contexts that nursing students confront in psychiatric clinical practices. Students were asked to document their everyday experience. The narratives were analysed and interpreted from the philosophical notion of hermeneutics. Four themes emerged as critical thinking contexts: anxiety, conflict, hyper-awareness, dilemmas. Writing narratives appear to provide opportunities for reflection in addition to facilitating critical thinking and communicative skills in students. Also, for the instructor, students' clinical narratives could provide insight to understand how students are thinking and to share student's personal difficulties.

  19. Analysis of Context Dependence in Social Interaction Networks of a Massively Multiplayer Online Role-Playing Game

    Science.gov (United States)

    Son, Seokshin; Kang, Ah Reum; Kim, Hyun-chul; Kwon, Taekyoung; Park, Juyong; Kim, Huy Kang

    2012-01-01

    Rapid advances in modern computing and information technology have enabled millions of people to interact online via various social network and gaming services. The widespread adoption of such online services have made possible analysis of large-scale archival data containing detailed human interactions, presenting a very promising opportunity to understand the rich and complex human behavior. In collaboration with a leading global provider of Massively Multiplayer Online Role-Playing Games (MMORPGs), here we present a network science-based analysis of the interplay between distinct types of user interaction networks in the virtual world. We find that their properties depend critically on the nature of the context-interdependence of the interactions, highlighting the complex and multilayered nature of human interactions, a robust understanding of which we believe may prove instrumental in the designing of more realistic future virtual arenas as well as provide novel insights to the science of collective human behavior. PMID:22496771

  20. Analysis of context dependence in social interaction networks of a massively multiplayer online role-playing game.

    Science.gov (United States)

    Son, Seokshin; Kang, Ah Reum; Kim, Hyun-chul; Kwon, Taekyoung; Park, Juyong; Kim, Huy Kang

    2012-01-01

    Rapid advances in modern computing and information technology have enabled millions of people to interact online via various social network and gaming services. The widespread adoption of such online services have made possible analysis of large-scale archival data containing detailed human interactions, presenting a very promising opportunity to understand the rich and complex human behavior. In collaboration with a leading global provider of Massively Multiplayer Online Role-Playing Games (MMORPGs), here we present a network science-based analysis of the interplay between distinct types of user interaction networks in the virtual world. We find that their properties depend critically on the nature of the context-interdependence of the interactions, highlighting the complex and multilayered nature of human interactions, a robust understanding of which we believe may prove instrumental in the designing of more realistic future virtual arenas as well as provide novel insights to the science of collective human behavior.

  1. Analysis of context dependence in social interaction networks of a massively multiplayer online role-playing game.

    Directory of Open Access Journals (Sweden)

    Seokshin Son

    Full Text Available Rapid advances in modern computing and information technology have enabled millions of people to interact online via various social network and gaming services. The widespread adoption of such online services have made possible analysis of large-scale archival data containing detailed human interactions, presenting a very promising opportunity to understand the rich and complex human behavior. In collaboration with a leading global provider of Massively Multiplayer Online Role-Playing Games (MMORPGs, here we present a network science-based analysis of the interplay between distinct types of user interaction networks in the virtual world. We find that their properties depend critically on the nature of the context-interdependence of the interactions, highlighting the complex and multilayered nature of human interactions, a robust understanding of which we believe may prove instrumental in the designing of more realistic future virtual arenas as well as provide novel insights to the science of collective human behavior.

  2. Operation Context

    DEFF Research Database (Denmark)

    Stüben, Henning; Tietjen, Anne

    2006-01-01

    Abstract: This paper seeks to challenge the notion of context from an operational perspective. Can we grasp the forces that shape the complex conditions for an architectural or urban design within the notion of context? By shifting the gaze towards the agency of architecture, contextual analysis...

  3. Comparative analysis of codon usage bias and codon context patterns between dipteran and hymenopteran sequenced genomes.

    Directory of Open Access Journals (Sweden)

    Susanta K Behura

    Full Text Available BACKGROUND: Codon bias is a phenomenon of non-uniform usage of codons whereas codon context generally refers to sequential pair of codons in a gene. Although genome sequencing of multiple species of dipteran and hymenopteran insects have been completed only a few of these species have been analyzed for codon usage bias. METHODS AND PRINCIPAL FINDINGS: Here, we use bioinformatics approaches to analyze codon usage bias and codon context patterns in a genome-wide manner among 15 dipteran and 7 hymenopteran insect species. Results show that GAA is the most frequent codon in the dipteran species whereas GAG is the most frequent codon in the hymenopteran species. Data reveals that codons ending with C or G are frequently used in the dipteran genomes whereas codons ending with A or T are frequently used in the hymenopteran genomes. Synonymous codon usage orders (SCUO vary within genomes in a pattern that seems to be distinct for each species. Based on comparison of 30 one-to-one orthologous genes among 17 species, the fruit fly Drosophila willistoni shows the least codon usage bias whereas the honey bee (Apis mellifera shows the highest bias. Analysis of codon context patterns of these insects shows that specific codons are frequently used as the 3'- and 5'-context of start and stop codons, respectively. CONCLUSIONS: Codon bias pattern is distinct between dipteran and hymenopteran insects. While codon bias is favored by high GC content of dipteran genomes, high AT content of genes favors biased usage of synonymous codons in the hymenopteran insects. Also, codon context patterns vary among these species largely according to their phylogeny.

  4. Automatic Classification of Users' Health Information Need Context: Logistic Regression Analysis of Mouse-Click and Eye-Tracker Data.

    Science.gov (United States)

    Pian, Wenjing; Khoo, Christopher Sg; Chi, Jianxing

    2017-12-21

    Users searching for health information on the Internet may be searching for their own health issue, searching for someone else's health issue, or browsing with no particular health issue in mind. Previous research has found that these three categories of users focus on different types of health information. However, most health information websites provide static content for all users. If the three types of user health information need contexts can be identified by the Web application, the search results or information offered to the user can be customized to increase its relevance or usefulness to the user. The aim of this study was to investigate the possibility of identifying the three user health information contexts (searching for self, searching for others, or browsing with no particular health issue in mind) using just hyperlink clicking behavior; using eye-tracking information; and using a combination of eye-tracking, demographic, and urgency information. Predictive models are developed using multinomial logistic regression. A total of 74 participants (39 females and 35 males) who were mainly staff and students of a university were asked to browse a health discussion forum, Healthboards.com. An eye tracker recorded their examining (eye fixation) and skimming (quick eye movement) behaviors on 2 types of screens: summary result screen displaying a list of post headers, and detailed post screen. The following three types of predictive models were developed using logistic regression analysis: model 1 used only the time spent in scanning the summary result screen and reading the detailed post screen, which can be determined from the user's mouse clicks; model 2 used the examining and skimming durations on each screen, recorded by an eye tracker; and model 3 added user demographic and urgency information to model 2. An analysis of variance (ANOVA) analysis found that users' browsing durations were significantly different for the three health information contexts

  5. Typical Responses in Giving Evaluation: An Analysis of High and Low Context Culture Communication

    Directory of Open Access Journals (Sweden)

    Ferany Arifin

    2013-05-01

    Full Text Available This paper aims at discussing high and low context in responses given by the students to evaluate their friend’s impromptu speech performance. The study focuses on the characteristics of high and low context represented specifically on (1 direct-indirect (2 simple-complex response, and (3 relationship orientation. The study is based on the analysis of ten responses given by ten students with different sexes. Classroom observation followed by transcription analysis is used. The data were collected naturally at undergraduate campus. The result shows that using indirect and complex responses can maintain harmonious relationship with others. The basic asumption is that the students tend to communicate in high level context. Penelitian ini bertujuan untuk membahas konteks tinggi dan rendah dalam mengevaluasi performansi pidato tanpa persiapan temannya. Penelitian ini memusatkan perhatian pada ciri konteks tinggi dan rendah yang direpresentasikan oleh (1 tanggapan langsung-tak langsung (2 sederhana-kompleks, dan (3 orientasi hubungan. Penelitian ini didasarkan pada sepuluh tanggapan yang diberikan oleh sepuluh mahasiswa pria dan wanita. Pengamatan kelas yang diikuti dengan analisis transkripsi digunakan untuk pengumpulan data. Data dikumpulkan di kampus diploma. Analisis menunjukkan bahwa siswa cenderung menggunakan tanggapan kompleks dan tak langsung agar dapat menjaga keharmonisan hubungan dengan temannya. Oleh karena itu asumsi dasarnya adalah bahwa siswa cenderung berkomunikasi dalam konteks level tinggi.

  6. The gendered health workforce: mixed methods analysis from four fragile and post-conflict contexts.

    Science.gov (United States)

    Witter, Sophie; Namakula, Justine; Wurie, Haja; Chirwa, Yotamu; So, Sovanarith; Vong, Sreytouch; Ros, Bandeth; Buzuzi, Stephen; Theobald, Sally

    2017-12-01

    It is well known that the health workforce composition is influenced by gender relations. However, little research has been done which examines the experiences of health workers through a gender lens, especially in fragile and post-conflict states. In these contexts, there may not only be opportunities to (re)shape occupational norms and responsibilities in the light of challenges in the health workforce, but also threats that put pressure on resources and undermine gender balance, diversity and gender responsive human resources for health (HRH). We present mixed method research on HRH in four fragile and post-conflict contexts (Sierra Leone, Zimbabwe, northern Uganda and Cambodia) with different histories to understand how gender influences the health workforce. We apply a gender analysis framework to explore access to resources, occupations, values, decision-making and power. We draw largely on life histories with male and female health workers to explore their lived experiences, but complement the analysis with evidence from surveys, document reviews, key informant interviews, human resource data and stakeholder mapping. Our findings shed light on patterns of employment: in all contexts women predominate in nursing and midwifery cadres, are under-represented in management positions and are clustered in lower paying positions. Gendered power relations shaped by caring responsibilities at the household level, affect attitudes to rural deployment and women in all contexts face challenges in accessing both pre- and in-service training. Coping strategies within conflict emerged as a key theme, with experiences here shaped by gender, poverty and household structure. Most HRH regulatory frameworks did not sufficiently address gender concerns. Unless these are proactively addressed post-crisis, health workforces will remain too few, poorly distributed and unable to meet the health needs of vulnerable populations. Practical steps need to be taken to identify gender

  7. A Cross-Context Analysis of Civic Engagement Linking CIVED and U.S: Census Data

    Directory of Open Access Journals (Sweden)

    Judith Torney-Purta

    2012-04-01

    Full Text Available This study investigates direct and indirect family, peer, school, and neighborhood effects on adolescents’ civic engagement utilizing data from the 1999 IEA Civic Education Study and the U.S. Census. The nationally representative sample consists of 2,729 students from 119 schools in the U.S. Multi-level regression techniques provide precise estimates of the separate and shared impact of each context on adolescents’ civic engagement. Individual students’ civic experiences and discourse in school and at home predict higher civic engagement, although the effects of these experiences vary based on the larger school and neighborhood contexts. Overall, interactive effects indicate that students who may traditionally be deemed at a disadvantage (either because of poor school or neighborhood conditions experience more benefits from increases in civic learning opportunities than do more advantaged students. Suggestions are made for secondary analyses of ICCS (the IEA civic education study of 2009.

  8. Biological time series analysis using a context free language: applicability to pulsatile hormone data.

    Directory of Open Access Journals (Sweden)

    Dennis A Dean

    Full Text Available We present a novel approach for analyzing biological time-series data using a context-free language (CFL representation that allows the extraction and quantification of important features from the time-series. This representation results in Hierarchically AdaPtive (HAP analysis, a suite of multiple complementary techniques that enable rapid analysis of data and does not require the user to set parameters. HAP analysis generates hierarchically organized parameter distributions that allow multi-scale components of the time-series to be quantified and includes a data analysis pipeline that applies recursive analyses to generate hierarchically organized results that extend traditional outcome measures such as pharmacokinetics and inter-pulse interval. Pulsicons, a novel text-based time-series representation also derived from the CFL approach, are introduced as an objective qualitative comparison nomenclature. We apply HAP to the analysis of 24 hours of frequently sampled pulsatile cortisol hormone data, which has known analysis challenges, from 14 healthy women. HAP analysis generated results in seconds and produced dozens of figures for each participant. The results quantify the observed qualitative features of cortisol data as a series of pulse clusters, each consisting of one or more embedded pulses, and identify two ultradian phenotypes in this dataset. HAP analysis is designed to be robust to individual differences and to missing data and may be applied to other pulsatile hormones. Future work can extend HAP analysis to other time-series data types, including oscillatory and other periodic physiological signals.

  9. Cloud Service Provider Methods for Managing Insider Threats: Analysis Phase 2, Expanded Analysis and Recommendations

    Science.gov (United States)

    2014-01-01

    and software as a service ( SaaS )) for staff’s abnormal behavior that may indicate an insider incident. As mentioned above, combining SIEM data...Mellon Software Engineering Institute, contacted commercial and government cloud service providers (CSPs) to better understand the administrative and...availability services . We have observed a number of scenarios in which a customer leaves a CSP’s IaaS, PaaS, or SaaS , but its data remains online for some

  10. Context-based coding of bilevel images enhanced by digital straight line analysis

    DEFF Research Database (Denmark)

    Aghito, Shankar Manuel; Forchhammer, Søren

    2006-01-01

    , or segmentation maps are also encoded efficiently. The algorithm is not targeted at document images with text, which can be coded efficiently with dictionary-based techniques as in JBIG2. The scheme is based on a local analysis of the digital straightness of the causal part of the object boundary, which is used...... in the context definition for arithmetic encoding. Tested on individual images of standard TV resolution binary shapes and the binary layers of a digital map, the proposed algorithm outperforms PWC, JBIG, JBIG2, and MPEG-4 CAE. On the binary shapes, the code lengths are reduced by 21%, 27 %, 28 %, and 41...

  11. Context based Coding of Binary Shapes by Object Boundary Straightness Analysis

    DEFF Research Database (Denmark)

    Aghito, Shankar Manuel; Forchhammer, Søren

    2004-01-01

    A new lossless compression scheme for bilevel images targeted at binary shapes of image and video objects is presented. The scheme is based on a local analysis of the digital straightness of the causal part of the object boundary, which is used in the context definition for arithmetic encoding....... Tested on individual images of binary shapes and binary layers of digital maps the algorithm outperforms PWC, JBIG and MPEG-4 CAE. On the binary shapes the code lengths are reduced by 21%, 25%, and 42%, respectively. On the maps the reductions are 34%, 32%, and 59%, respectively. The algorithm is also...

  12. Comparative Analysis of Fuzzy Set Defuzzification Methods in the Context of Ecological Risk Assessment

    Directory of Open Access Journals (Sweden)

    Užga-Rebrovs Oļegs

    2017-12-01

    Full Text Available Fuzzy inference systems are widely used in various areas of human activity. Their most widespread use lies in the field of fuzzy control of technical devices of different kind. Another direction of using fuzzy inference systems is modelling and assessment of different kind of risks under insufficient or missing objective initial data. Fuzzy inference is concluded by the procedure of defuzzification of the resulting fuzzy sets. A large number of techniques for implementing the defuzzification procedure are available nowadays. The paper presents a comparative analysis of some widespread methods of fuzzy set defuzzification, and proposes the most appropriate methods in the context of ecological risk assessment.

  13. Adult education and publishing Canadian fiction in a global context: a Foucauldian analysis

    Directory of Open Access Journals (Sweden)

    Susan M Holloway

    2014-04-01

    Full Text Available This paper draws upon findings from a research study on the relationship between fiction, citizenship, and lifelong learning. It includes interviews with authors from several genres, publishing houses, and arts councils. This paper explores many of the ambivalent outcomes of the shifting power elements in publishing that can simultaneously benefit and disadvantage the publication of a national body of fiction. Although focused on the Canadian context, fiction writers and publishers around the globe face similar challenges. Using a Foucauldian analysis, it considers the importance of fiction and adult learning in shaping discourses of citizenship and critical social learning.

  14. Information needs: an sociocognitive analysis in academic management in the context of regulation

    Directory of Open Access Journals (Sweden)

    Nadi Helena Presser

    2012-12-01

    Full Text Available It presents a sociocognitive analysis of information needs investigation that arises from the different tasks that the coordinators of the graduate studies take in their activity. The context of regulation, research subject, constitutes in the social environment under which information are produced and used. The study of the document of Applied Social Sciences I area composed the empirical basis of research. It was found that the information needs, which arise from the set of tasks which are in the center of regulation, are formed in the academic communities. At the same time they produce complex results, many tasks can be decomposed into understandable elements and identified information needs.

  15. A Global Meta-Analysis of the Value of Ecosystem Services Provided by Lakes.

    Science.gov (United States)

    Reynaud, Arnaud; Lanzanova, Denis

    2017-07-01

    This study presents the first meta-analysis on the economic value of ecosystem services delivered by lakes. A worldwide data set of 699 observations drawn from 133 studies combines information reported in primary studies with geospatial data. The meta-analysis explores antagonisms and synergies between ecosystem services. This is the first meta-analysis to incorporate simultaneously external geospatial data and ecosystem service interactions. We first show that it is possible to reliably predict the value of ecosystem services provided by lakes based on their physical and geographic characteristics. Second, we demonstrate that interactions between ecosystem services appear to be significant for explaining lake ecosystem service values. Third, we provide an estimation of the average value of ecosystem services provided by lakes: between 106 and 140 USD$2010 per respondent per year for non-hedonic price studies and between 169 and 403 USD$2010 per property per year for hedonic price studies.

  16. Economic solvency in the context of violence against women: a concept analysis.

    Science.gov (United States)

    Gilroy, Heidi; Symes, Lene; McFarlane, Judith

    2015-03-01

    The aim of this concept analysis is to define economic solvency in the context of violence against women. Poverty, or lack of resources, is often discussed as a risk factor for intimate partner violence. The concept of economic solvency, which may be a protective factor for women, is less often discussed and not well defined. Databases searched for the analysis included EBSCOhost, CINAHL, PubMed and Gender Watch. The Rodgers evolutionary method was used to perform the concept analysis. A total of 134 articles were retrieved, using the specified search terms 'economic solvency and women', 'economic self-reliance and women' and 'economic self-sufficiency and women'. Articles were included if they were peer reviewed, contained the keywords with sufficient context to determine the author's intended meaning, and focused on women only or contrasted men to women. Thirty-five articles were used in the concept analysis. The definition of economic solvency drawn from the concept analysis is: a long-term state that occurs when there is societal structure that supports gender equity and external resources are available and can be used by a woman who has necessary human capital, sustainable employment and independence. Just as poverty and violence are cyclical, so are economic solvency and empowerment of women. To decrease women's risk of intimate partner violence around the world and further improve the status of women, we recommend continued research on economic solvency, including the individual, family, community and societal resources required to obtain economic solvency and the human capital characteristics needed for sustainability. © 2014 John Wiley & Sons Ltd.

  17. RACLOUDS - Model for Clouds Risk Analysis in the Information Assets Context

    Directory of Open Access Journals (Sweden)

    SILVA, P. F.

    2016-06-01

    Full Text Available Cloud computing offers benefits in terms of availability and cost, but transfers the responsibility of information security management for the cloud service provider. Thus the consumer loses control over the security of their information and services. This factor has prevented the migration to cloud computing in many businesses. This paper proposes a model where the cloud consumer can perform risk analysis on providers before and after contracting the service. The proposed model establishes the responsibilities of three actors: Consumer, Provider and Security Labs. The inclusion of actor Security Labs provides more credibility to risk analysis making the results more consistent for the consumer.

  18. Cloud Service Provider Methods for Managing Insider Threats: Analysis Phase 1

    Science.gov (United States)

    2013-11-01

    of Standards and Technology (NIST) Special Publication 800-145 (NIST SP 800-145) defines three types of cloud services : Software as a Service ( SaaS ...among these three models. NIST SP 800-145 describes the three service models as follows: SaaS —The capability provided to the consumer is to use the...Cloud Service Provider Methods for Managing Insider Threats: Analysis Phase I Greg Porter November 2013 TECHNICAL NOTE CMU/SEI-2013-TN-020

  19. Analysis of the genetic basis of disease in the context of worldwide human relationships and migration.

    Directory of Open Access Journals (Sweden)

    Erik Corona

    2013-05-01

    Full Text Available Genetic diversity across different human populations can enhance understanding of the genetic basis of disease. We calculated the genetic risk of 102 diseases in 1,043 unrelated individuals across 51 populations of the Human Genome Diversity Panel. We found that genetic risk for type 2 diabetes and pancreatic cancer decreased as humans migrated toward East Asia. In addition, biliary liver cirrhosis, alopecia areata, bladder cancer, inflammatory bowel disease, membranous nephropathy, systemic lupus erythematosus, systemic sclerosis, ulcerative colitis, and vitiligo have undergone genetic risk differentiation. This analysis represents a large-scale attempt to characterize genetic risk differentiation in the context of migration. We anticipate that our findings will enable detailed analysis pertaining to the driving forces behind genetic risk differentiation.

  20. Visual analysis of transcriptome data in the context of anatomical structures and biological networks

    Directory of Open Access Journals (Sweden)

    Astrid eJunker

    2012-11-01

    Full Text Available The complexity and temporal as well as spatial resolution of transcriptome datasets is constantly increasing due to extensive technological developments. Here we present methods for advanced visualization and intuitive exploration of transcriptomics data as necessary prerequisites in order to facilitate the gain of biological knowledge. Color-coding of structural images based on the expression level enables a fast visual data analysis in the background of the examined biological system. The network-based exploration of these visualizations allows for comparative analysis of genes with specific transcript patterns and supports the extraction of functional relationships even from large datasets. In order to illustrate the presented methods, the tool HIVE was applied for visualization and exploration of database-retrieved expression data for master regulators of Arabidopsis thaliana flower and seed development in the context of corresponding tissue-specific regulatory networks.

  1. Health organizations providing and seeking social support: a Twitter-based content analysis.

    Science.gov (United States)

    Rui, Jian Raymond; Chen, Yixin; Damiano, Amanda

    2013-09-01

    Providing and seeking social support are important aspects of social exchange. New communication technologies, especially social network sites (SNSs), facilitate the process of support exchange. An increasing number of health organizations are using SNSs. However, how they provide and seek social support via SNSs has yet to garner academic attention. This study examined the types of social support provided and sought by health organizations on Twitter. A content analysis was conducted on 1,500 tweets sent by a random sample of 58 health organizations within 2 months. Findings indicate that providing informational and emotional support, as well as seeking instrumental support, were the main types of social support exchanged by health organizations through Twitter. This study provides a typology for studying social support exchanges by health organizations, and recommends strategies for health organizations regarding the effective use of Twitter.

  2. Experimental analysis of the influence of context awareness on service discovery in PNs

    DEFF Research Database (Denmark)

    Olsen, Rasmus Løvenstein; Nickelsen, Anders; Nielsen, Jimmy Jessen

    2006-01-01

    In this paper we present an experimental prototype for context aware service discovery specifically aimed for Personal Networks. In the paper the concept of context aware service discovery, an architecture and the necessary components for performing context aware service discovery in Personal...... Networks is presented. The paper also presents a set of preliminary performance results of context aware service discovery. This is compared to normal service discovery, and as expected context awareness costs in performance....

  3. Can Raters with Reduced Job Descriptive Information Provide Accurate Position Analysis Questionnaire (PAQ) Ratings?

    Science.gov (United States)

    Friedman, Lee; Harvey, Robert J.

    1986-01-01

    Job-naive raters provided with job descriptive information made Position Analysis Questionnaire (PAQ) ratings which were validated against ratings of job analysts who were also job content experts. None of the reduced job descriptive information conditions enabled job-naive raters to obtain either acceptable levels of convergent validity with…

  4. Teleradiology from the provider's perspective-cost analysis for a mid-size university hospital.

    Science.gov (United States)

    Rosenberg, Christian; Kroos, Kristin; Rosenberg, Britta; Hosten, Norbert; Flessa, Steffen

    2013-08-01

    Real costs of teleradiology services have not been systematically calculated. Pricing policies are not evidence-based. This study aims to prove the feasibility of performing an original cost analysis for teleradiology services and show break-even points to perform cost-effective practice. Based on the teleradiology services provided by the Greifswald University Hospital in northeastern Germany, a detailed process analysis and an activity-based costing model revealed costs per service unit according to eight examination categories. The Monte Carlo method was used to simulate the cost amplitude and identify pricing thresholds. Twenty-two sub-processes and four staff categories were identified. The average working time for one unit was 55 (x-ray) to 72 min (whole-body CT). Personnel costs were dominant (up to 68 %), representing lower limit costs. The Monte Carlo method showed the cost distribution per category according to the deficiency risk. Avoiding deficient pricing by a likelihood of 90 % increased the cost of a cranial CT almost twofold as compared with the lower limit cost. Original cost analysis is possible when providing teleradiology services with complex statutory requirements in place. Methodology and results provide useful data to help enhance efficiency in hospital management as well as implement realistic reimbursement fees. • Analysis of original costs of teleradiology is possible for a providing hospital • Results discriminate pricing thresholds and lower limit costs to perform cost-effective practice • The study methods represent a managing tool to enhance efficiency in providing facilities • The data are useful to help represent telemedicine services in regular medical fee schedules.

  5. Understanding interprofessional collaboration in the context of chronic disease management for older adults living in communities: a concept analysis.

    Science.gov (United States)

    Bookey-Bassett, Sue; Markle-Reid, Maureen; Mckey, Colleen A; Akhtar-Danesh, Noori

    2017-01-01

    To report a concept analysis of interprofessional collaboration in the context of chronic disease management, for older adults living in communities. Increasing prevalence of chronic disease among older adults is creating significant burden for patients, families and healthcare systems. Managing chronic disease for older adults living in the community requires interprofessional collaboration across different health and other care providers, organizations and sectors. However, there is a lack of consensus about the definition and use of interprofessional collaboration for community-based chronic disease management. Concept analysis. Electronic databases CINAHL, Medline, HealthStar, EMBASE, PsychINFO, Ageline and Cochrane Database were searched from 2000 - 2013. Rodgers' evolutionary method for concept analysis. The most common surrogate term was interdisciplinary collaboration. Related terms were interprofessional team, multidisciplinary team and teamwork. Attributes included: an evolving interpersonal process; shared goals, decision-making and care planning; interdependence; effective and frequent communication; evaluation of team processes; involving older adults and family members in the team; and diverse and flexible team membership. Antecedents comprised: role awareness; interprofessional education; trust between team members; belief that interprofessional collaboration improves care; and organizational support. Consequences included impacts on team composition and function, care planning processes and providers' knowledge, confidence and job satisfaction. Interprofessional collaboration is a complex evolving concept. Key components of interprofessional collaboration in chronic disease management for community-living older adults are identified. Implications for nursing practice, education and research are proposed. © 2016 John Wiley & Sons Ltd.

  6. Capturing Context-Related Change in Emotional Dynamics via Fixed Moderated Time Series Analysis.

    Science.gov (United States)

    Adolf, Janne K; Voelkle, Manuel C; Brose, Annette; Schmiedek, Florian

    2017-01-01

    Much of recent affect research relies on intensive longitudinal studies to assess daily emotional experiences. The resulting data are analyzed with dynamic models to capture regulatory processes involved in emotional functioning. Daily contexts, however, are commonly ignored. This may not only result in biased parameter estimates and wrong conclusions, but also ignores the opportunity to investigate contextual effects on emotional dynamics. With fixed moderated time series analysis, we present an approach that resolves this problem by estimating context-dependent change in dynamic parameters in single-subject time series models. The approach examines parameter changes of known shape and thus addresses the problem of observed intra-individual heterogeneity (e.g., changes in emotional dynamics due to observed changes in daily stress). In comparison to existing approaches to unobserved heterogeneity, model estimation is facilitated and different forms of change can readily be accommodated. We demonstrate the approach's viability given relatively short time series by means of a simulation study. In addition, we present an empirical application, targeting the joint dynamics of affect and stress and how these co-vary with daily events. We discuss potentials and limitations of the approach and close with an outlook on the broader implications for understanding emotional adaption and development.

  7. Factors Influencing Nursing Students' Clinical Judgment: A Qualitative Directed Content Analysis in an Iranian Context.

    Science.gov (United States)

    Pouralizadeh, Moluk; Khankeh, Hamidreza; Ebadi, Abbas; Dalvandi, Asghar

    2017-05-01

    Clinical judgment is necessary for clinical decision making and enhancing it in nursing students improves health care quality. Since clinical judgment is an interactive phenomenon and dependent on context and culture, it can be affected by many different factors. To understand the experiences of Iranian nursing students and teachers about the factors influencing nursing students' clinical judgment. A qualitative study was conducted using a directed content analysis approach. In this study, purposive sampling and semi-structured interviews were applied with seven nursing students, six faculty member teachers and four clinical instructors from Guilan University of Medical Sciences, Gilan, Iran. The factors influencing nursing students' clinical judgment consisted of five main categories including thoughtful behaviour, professional ethics, use of evidence based care, the context of learning environment and individual and professional features of clinical teachers. Relying on the results of this research, teachers can create an appropriate educational condition and a safe psychological atmosphere, use instructional strategies strengthening deep thought processes, applying professional ethics and scientific evidence and principles to establish clinical judgment in nursing students.

  8. ComPath: comparative enzyme analysis and annotation in pathway/subsystem contexts

    Directory of Open Access Journals (Sweden)

    Kim Sun

    2008-03-01

    to get context information that is complementary to conventional KEGG map representation. Conclusion ComPath is an interactive workbench for pathway reconstruction, annotation, and analysis where experts can perform various sequence, domain, context analysis, using an intuitive and interactive spreadsheet-style interface.

  9. Imagined in Policy, Inscribed on Bodies: Defending an Ethic of Compassion in a Political Context: Comment on "Why and How Is Compassion Necessary to Provide Good Quality Healthcare?".

    Science.gov (United States)

    Mercer, Dave

    2015-07-10

    In response to the International Journal of Health Policy and Management (IJHPM) editorial, this commentary adds to the debate about ethical dimensions of compassionate care in UK service provision. It acknowledges the importance of the original paper, and attempts to explore some of the issues that are raised in the context of nursing practice, research and education. It is argued that each of these fields of the profession are enacted in an escalating culture of corporatism, be that National Health Service (NHS) or university campus, and global neoliberalism. Post-structuralist ideas, notably those of Foucault, are borrowed to interrogate healthcare as discursive practice and disciplinary knowledge; where an understanding of the ways in which power and language operate is prominent. Historical and contemporary evidence of institutional and ideological degradation of sections of humanity, a 'history of the present,' serve as reminders of the import, and fragility, of ethical codes. © 2015 by Kerman University of Medical Sciences.

  10. Aspects of incidence of convergence telejournalism: analysis of fragments of context instances Brazilian

    Directory of Open Access Journals (Sweden)

    Eloisa Joseane da Cunha Klein

    2012-12-01

    Full Text Available This text reflects on the affectations of mediatization on the field of journalism in the context of digital convergence, considering changes in news production, shift in the relationship of the actors in the field and with the reception. The text makes preliminary considerations on the ways in which television journalism interacts with digital tools - from partial analysis of how television program Profession Reporter uses such tools. Also stressed are two cases on the affectation of the social uses of digital media on the television news: the first, linked to the impact of a Profession Reporter edition on domestic violence (2009, the second, the impact of a case highlighted in social networks in TV journalism. Thus, we consider the issues of communication circulation, accentuated by digital convergence

  11. COMPARATIVE ANALYSIS OF PERSONALITY CORRELATES OF REFLEXIVITY IN THE CONTEXT OF PROFESSIONAL FORMATION OF THE TEACHER

    Directory of Open Access Journals (Sweden)

    T. V. Mayasova

    2017-01-01

    Full Text Available This article examines the reflexive, the most important professional quality of a teacher's personality in the context of professional development. Reflexivity is a basic property of the individual, whereby the awareness and regulation of the subject of their activities. As a personal correlates of reflexivity studied mental stability, individual styles of decision making (vigilance and avoidance, spontaneity, emotional intelligence (empathy and the ability to manage emotions of other people. The paper conducts a comparative analysis of reflexivity and qualities correlated with her young teachers, working in the specialty from 1 to 5 years and students from different areas of training of pedagogical University. Obtained in the course of the empirical research results confirmed that the process of professional development of teachers is the development of these qualities. Were no significant differences in the indicators options system the reflexivity, alertness,spontaneity, empathy, which differ among teachers and students.

  12. An analysis of teacher news in Turkish printed media within the context of teachers’ image

    Directory of Open Access Journals (Sweden)

    Hüseyin Polat

    2016-12-01

    Full Text Available The purpose of this study was to analyze the news about teachers in daily newspapers circulated in Turkey. To this end, the newspapers of Zaman, Posta, Hurriyet, Sabah, and Cumhuriyet were selected and scanned for the teacher news between the dates of 01 January 2014 and 31 December 2014. Document analysis technique was used for the scanned news. The data obtained were expressed in frequencies and percentages according to the aim. News about the teachers was grouped on the basis of type, content, and characteristics and the teacher profile presented from this data was set forth. Teachers are mainly covered in the newspapers in sexual abuse and violence contexts; besides, the teacher profile formed on the basis of newspaper reports was found to be a negative one.

  13. Narrative thematic analysis of baccalaureate nursing students' reflections: critical thinking in the clinical education context.

    Science.gov (United States)

    Naber, Jessica L; Hall, Joanne; Schadler, Craig Matthew

    2014-09-01

    This study sought to identify characteristics of clinically situated critical thinking in nursing students' reflections, originally part of a study guided by Richard Paul's model of critical thinking. Nurses are expected to apply critical thinking in all practice situations to improve health outcomes, including patient safety and satisfaction. In a previous study, Paul's model of critical thinking was used to develop questions for reflective writing assignments. Within that study, 30 nursing students completed six open-ended narratives of nurse-patient clinical encounters during an 8-week period. Improvements were seen in critical thinking scores after the intervention. This article reports the qualitative analysis of the content of six open-ended narratives. Six overarching themes were identified and combined into a tentative conceptual model. Faculty's understanding of the characteristics of critical thinking in the context of clinical education will help them to teach and evaluate students' progress and competencies for future practice.

  14. An approach for modelling interdependent infrastructures in the context of vulnerability analysis

    International Nuclear Information System (INIS)

    Johansson, Jonas; Hassel, Henrik

    2010-01-01

    Technical infrastructures of the society are becoming more and more interconnected and interdependent, i.e. the function of an infrastructure influences the function of other infrastructures. Disturbances in one infrastructure therefore often traverse to other dependent infrastructures and possibly even back to the infrastructure where the failure originated. It is becoming increasingly important to take these interdependencies into account when assessing the vulnerability of technical infrastructures. In the present paper, an approach for modelling interdependent technical infrastructures is proposed. The modelling approach considers structural properties, as employed in graph theory, as well as functional properties to increase its fidelity and usefulness. By modelling a fictional electrified railway network that consists of five systems and interdependencies between the systems, it is shown how the model can be employed in a vulnerability analysis. The model aims to capture both functional and geographic interdependencies. It is concluded that the proposed modelling approach is promising and suitable in the context of vulnerability analyses of interdependent systems.

  15. Behavior Analysis and Ecological Psychology: Past, Present, and Future. A Review of Harry Heft's Ecological Psychology in Context

    Science.gov (United States)

    Morris, Edward K

    2009-01-01

    Relations between behavior analysis and ecological psychology have been strained for years, notwithstanding the occasional comment on their affinities. Harry Heft's (2001) Ecological Psychology in Context provides an occasion for reviewing anew those relations and affinities. It describes the genesis of ecological psychology in James's radical empiricism; addresses Holt's neorealism and Gestalt psychology; and synthesizes Gibson's ecological psychology and Barker's ecobehavioral science as a means for understanding everyday human behavior. Although behavior analysis is excluded from this account, Heft's book warrants a review nonetheless: It describes ecological psychology in ways that are congruent and complementary with behavior analysis (e.g., nonmediational theorizing; the provinces of natural history and natural science). After introducing modern ecological psychology, I comment on (a) Heft's admirable, albeit selective, historiography; (b) his ecological psychology—past and present—as it relates to Skinner's science and system (e.g., affordances, molar behavior); (c) his misunderstandings of Skinner's behaviorism (e.g., reductionistic, mechanistic, molecular); and (d) the theoretical status of Heft's cognitive terms and talk (i.e., in ontology, epistemology, syntax). I conclude by considering the alliance and integration of ecological psychology and behavior analysis, and their implications for unifying and transforming psychology as a life science, albeit more for the future than at present. PMID:20354604

  16. Metabolomic Analysis Provides Insights on Paraquat-Induced Parkinson-Like Symptoms in Drosophila melanogaster.

    Science.gov (United States)

    Shukla, Arvind Kumar; Ratnasekhar, Ch; Pragya, Prakash; Chaouhan, Hitesh Singh; Patel, Devendra Kumar; Chowdhuri, Debapratim Kar; Mudiam, Mohana Krishna Reddy

    2016-01-01

    Paraquat (PQ) exposure causes degeneration of the dopaminergic neurons in an exposed organism while altered metabolism has a role in various neurodegenerative disorders. Therefore, the study presented here was conceived to depict the role of altered metabolism in PQ-induced Parkinson-like symptoms and to explore Drosophila as a potential model organism for such studies. Metabolic profile was generated in control and in flies that were fed PQ (5, 10, and 20 mM) in the diet for 12 and 24 h concurrent with assessment of indices of oxidative stress, dopaminergic neurodegeneration, and behavioral alteration. PQ was found to significantly alter 24 metabolites belonging to different biological pathways along with significant alterations in the above indices. In addition, PQ attenuated brain dopamine content in the exposed organism. The study demonstrates that PQ-induced alteration in the metabolites leads to oxidative stress and neurodegeneration in the exposed organism along with movement disorder, a phenotype typical of Parkinson-like symptoms. The study is relevant in the context of Drosophila and humans because similar alteration in the metabolic pathways has been observed in both PQ-exposed Drosophila and in postmortem samples of patients with Parkinsonism. Furthermore, this study provides advocacy towards the applicability of Drosophila as an alternate model organism for pre-screening of environmental chemicals for their neurodegenerative potential with altered metabolism.

  17. Context based computational analysis and characterization of ARS consensus sequences (ACS of Saccharomyces cerevisiae genome

    Directory of Open Access Journals (Sweden)

    Vinod Kumar Singh

    2016-09-01

    Full Text Available Genome-wide experimental studies in Saccharomyces cerevisiae reveal that autonomous replicating sequence (ARS requires an essential consensus sequence (ACS for replication activity. Computational studies identified thousands of ACS like patterns in the genome. However, only a few hundreds of these sites act as replicating sites and the rest are considered as dormant or evolving sites. In a bid to understand the sequence makeup of replication sites, a content and context-based analysis was performed on a set of replicating ACS sequences that binds to origin-recognition complex (ORC denoted as ORC-ACS and non-replicating ACS sequences (nrACS, that are not bound by ORC. In this study, DNA properties such as base composition, correlation, sequence dependent thermodynamic and DNA structural profiles, and their positions have been considered for characterizing ORC-ACS and nrACS. Analysis reveals that ORC-ACS depict marked differences in nucleotide composition and context features in its vicinity compared to nrACS. Interestingly, an A-rich motif was also discovered in ORC-ACS sequences within its nucleosome-free region. Profound changes in the conformational features, such as DNA helical twist, inclination angle and stacking energy between ORC-ACS and nrACS were observed. Distribution of ACS motifs in the non-coding segments points to the locations of ORC-ACS which are found far away from the adjacent gene start position compared to nrACS thereby enabling an accessible environment for ORC-proteins. Our attempt is novel in considering the contextual view of ACS and its flanking region along with nucleosome positioning in the S. cerevisiae genome and may be useful for any computational prediction scheme.

  18. How electricity providers communicate price increases – A qualitative analysis of notification letters

    International Nuclear Information System (INIS)

    Pick, Doreén; Zielke, Stephan

    2015-01-01

    In several markets firms are required to explicitly announce price increases by sending customers notification letters. The purpose of this article is to analyze how electricity providers deal with such obligatory price increase communication and to provide a comprehensive overview of communicative arguments used by firms. Data is gathered through a content analysis of 97 price increase mailings. Findings show that electricity providers apply several price communication strategies while other promising strategies for customer retention are mostly ignored (i.e., those related to competitors, offerings and relationship benefits). Further, price increase communication differs between national and local firms. Local firms are more transparent in their price increase communication and refer even less often to offer and relationship benefits. Electricity firms have many options to improve the potential effects of price increase letters, such as referring to the future relationship. This is the first study which examines the content of price increase communication by firms. It structures price communication practices used by electricity providers, analyzes their empirical relevance, summarizes findings in five global propositions, and provides a detailed agenda for future research. Moreover, the study indicates several means for public policy organizations to offer regulations on the content of price increase notifications. - Highlights: • We examine 97 price increase letters from electricity providers in Germany. • We investigate the means how firms deal with price increase communications. • Electricity providers aim to hide price increases towards their customers. • Electricity providers only scarcely use benefit and relationship communication. • Price increase communication differs between types of providers as national firms are more professional.

  19. Analysis of outpatient healthcare utilization in the context of the universal healthcare coverage reform in Mexico.

    Directory of Open Access Journals (Sweden)

    Sergio Bautista-Arredondo

    2014-01-01

    Full Text Available Objective. Understand and quantify the relationship between socio-economic and health insurance profiles and the use of outpatient medical services in the context of universal health care in Mexico. Materials and methods. Using ENSANUT 2012 multinomial regression models were estimated to analyze the use of outpatient services and associated factors. Results. Population with greater poverty levels, lower educational level and living in highly marginalized areas have lower odds to use outpatient health services. In contrast, health insurance and higher income increase the odds to use health services and influence the choice of provider. Conclusions. Barriers to access to health care related to poverty and social protection persist. However, there is space to lower the effect of these barriers by addressing constraints linked to the supply and the perceived quality of healthcare services.

  20. [Analysis of outpatient healthcare utilization in the context of the universal healthcare coverage reform in Mexico].

    Science.gov (United States)

    Bautista-Arredondo, Sergio; Serván-Mori, Edson; Colchero, M Arantxa; Ramírez-Rodríguez, Baruch; Sosa-Rubí, Sandra G

    2014-01-01

    Understand and quantify the relationship between socio-economic and health insurance profiles and the use of outpatient medical services in the context of universal health care in Mexico. Using ENSANUT 2012 multinomial regression models were estimated to analyze the use of outpatient services and associated factors. Population with greater poverty levels, lower educational level and living in highly marginalized areas have lower odds to use outpatient health services. In contrast, health insurance and higher income increase the odds to use health services and influence the choice of provider. Barriers to access to health care related to poverty and social protection persist. However, there is space to lower the effect of these barriers by addressing constraints linked to the supply and the perceived quality of healthcare services.

  1. Analysis of Means for Building Context-Aware Recommendation System for Mobile Learning

    Science.gov (United States)

    Shcherbachenko, Larysa; Nowakowski, Samuel

    2017-01-01

    One of the rapidly developing tools for online learning is learning through a mobile environment. Therefore, developing and improving mobile learning environments is an active topic now. One of the ways to adapt the learning environment to the user's needs is to use his context. Context of the user consists of the current context in online…

  2. Technoeconomics analysis of a photovoltaic system to provide electricity for a household in Malaysia

    International Nuclear Information System (INIS)

    Alamsyah, T.M.I.; Kamaruzzaman Sopian; Shahrir, A

    2006-01-01

    Malaysia is very fortunate because located in the tropical region where the used of solar energy is one of the most promising renewable energy sources in the country. This paper is a study on a photovoltaic (Pv) system to provide the electricity for a single residential household. The effect of solar intensity and surface temperature variation on the amount of power provided by PV panels in selected location in Malaysia is determined in this study. The Life cycle cost analysis is conducted to compare electricity price with other energy sources in this country. It is found that providing electricity for a household by using PV system seems to be beneficial and competitive for long term investment, especially if the price of the system is decrease and the efficiency is increase

  3. Needs Analysis in ESP Context: Saudi Engineering Students as a Case Study

    Directory of Open Access Journals (Sweden)

    Hashem Ahmed Alsamadani

    2017-12-01

    Full Text Available Needs analysis can be a vital asset for teachers of English for specific purposes (ESP to identify their learners’ key requirements or needs and determine the areas in which they are lacking skills. Against this background, this study was undertaken during the academic year 2015-16 to define the English language needs of engineering students (N= 200 majoring in civil engineering and industrial engineering. The data of this study was collected from different sources, including a classroom observation protocol, a questionnaire, and a semi-structured interview with both ESP and subject-matter teachers (SM at Umm Al-Qura University. Results of the data analysis offered significant insights as to the teaching of ESP course. The study revealed that receptive skills (i.e., reading and listening were mostly focused on in ESP classes. It has been also reported that writing and reading along with speaking skills were needed more than others. The data analysis helped to determine the most important language tasks in the context of engineering studies. Finally, a call was being made by both ESP and SM teachers to enhance the quality of the ESP course taught to engineering students by offering relevant suggestions. Based on these findings, the present study concluded with implications for course designers and recommendations for future studies.

  4. Genome-wide comparative analysis of codon usage bias and codon context patterns among cyanobacterial genomes.

    Science.gov (United States)

    Prabha, Ratna; Singh, Dhananjaya P; Sinha, Swati; Ahmad, Khurshid; Rai, Anil

    2017-04-01

    With the increasing accumulation of genomic sequence information of prokaryotes, the study of codon usage bias has gained renewed attention. The purpose of this study was to examine codon selection pattern within and across cyanobacterial species belonging to diverse taxonomic orders and habitats. We performed detailed comparative analysis of cyanobacterial genomes with respect to codon bias. Our analysis reflects that in cyanobacterial genomes, A- and/or T-ending codons were used predominantly in the genes whereas G- and/or C-ending codons were largely avoided. Variation in the codon context usage of cyanobacterial genes corresponded to the clustering of cyanobacteria as per their GC content. Analysis of codon adaptation index (CAI) and synonymous codon usage order (SCUO) revealed that majority of genes are associated with low codon bias. Codon selection pattern in cyanobacterial genomes reflected compositional constraints as major influencing factor. It is also identified that although, mutational constraint may play some role in affecting codon usage bias in cyanobacteria, compositional constraint in terms of genomic GC composition coupled with environmental factors affected codon selection pattern in cyanobacterial genomes. Copyright © 2016 Elsevier B.V. All rights reserved.

  5. Health-Related Quality of Life after Pediatric Liver Transplantation: A Qualitative Analysis of the Perspectives of Health Care Providers

    Directory of Open Access Journals (Sweden)

    Mar Miserachs

    2017-01-01

    Full Text Available With improved survival outcomes after pediatric liver transplantation (LT, health-related quality of life (HRQoL is an important outcome metric. Understanding the elements contributing to HRQoL after LT in children would enable more targeted strategies towards optimizing best outcomes. This qualitative study aimed to explore health care providers (HCP perceptions about HRQoL after pediatric LT. Thirteen experienced HCP participated in two focus group discussions. Data analysis via a thematic analysis approach revealed 4 major themes: “LT as a facilitator of better HRQoL,” “coping and adapting to LT,” “living with a transplanted liver,” and “the family context.” HCP identified elements that both enhance (improved physical health, peer relationship, and activities of daily living and challenge (need for immunosuppression, transplant follow-up, and restrictions the multidimensional domains of HRQoL. HCP perceived LT to be a stressful life-changing event for children and their families. Patients and their parents’ ability to cope and adjust positively to LT was perceived as a key contributor to better HRQoL. HCP perspective highlights the importance of promoting psychosocial support and a family-centered care delivery model towards the overarching goal of optimizing durable outcomes.

  6. Context Aware Middleware Architectures: Survey and Challenges

    Directory of Open Access Journals (Sweden)

    Xin Li

    2015-08-01

    Full Text Available Context aware applications, which can adapt their behaviors to changing environments, are attracting more and more attention. To simplify the complexity of developing applications, context aware middleware, which introduces context awareness into the traditional middleware, is highlighted to provide a homogeneous interface involving generic context management solutions. This paper provides a survey of state-of-the-art context aware middleware architectures proposed during the period from 2009 through 2015. First, a preliminary background, such as the principles of context, context awareness, context modelling, and context reasoning, is provided for a comprehensive understanding of context aware middleware. On this basis, an overview of eleven carefully selected middleware architectures is presented and their main features explained. Then, thorough comparisons and analysis of the presented middleware architectures are performed based on technical parameters including architectural style, context abstraction, context reasoning, scalability, fault tolerance, interoperability, service discovery, storage, security & privacy, context awareness level, and cloud-based big data analytics. The analysis shows that there is actually no context aware middleware architecture that complies with all requirements. Finally, challenges are pointed out as open issues for future work.

  7. Temporal-pattern similarity analysis reveals the beneficial and detrimental effects of context reinstatement on human memory.

    Science.gov (United States)

    Staudigl, Tobias; Vollmar, Christian; Noachtar, Soheyl; Hanslmayr, Simon

    2015-04-01

    A powerful force in human memory is the context in which memories are encoded (Tulving and Thomson, 1973). Several studies suggest that the reinstatement of neural encoding patterns is beneficial for memory retrieval (Manning et al., 2011; Staresina et al., 2012; Jafarpour et al., 2014). However, reinstatement of the original encoding context is not always helpful, for instance, when retrieving a memory in a different contextual situation (Smith and Vela, 2001). It is an open question whether such context-dependent memory effects can be captured by the reinstatement of neural patterns. We investigated this question by applying temporal and spatial pattern similarity analysis in MEG and intracranial EEG in a context-match paradigm. Items (words) were tagged by individual dynamic context stimuli (movies). The results show that beta oscillatory phase in visual regions and the parahippocampal cortex tracks the incidental reinstatement of individual context trajectories on a single-trial level. Crucially, memory benefitted from reinstatement when the encoding and retrieval contexts matched but suffered from reinstatement when the contexts did not match. Copyright © 2015 the authors 0270-6474/15/355373-12$15.00/0.

  8. Context incorporation using context-aware language features

    OpenAIRE

    Vlachostergiou, Aggeliki; Marandianos, George; Kollias, Stefanos

    2017-01-01

    This paper investigates the problem of context incorporation into human language systems and particular in Sentiment Analysis (SA) systems. So far, the analysis of how different features, when incorporated into such systems, improve their performance, has been discussed in a number of studies. However, a complete picture of their effectiveness remains unexplored. With this work, we attempt to extend the pool of the context - aware language features at the sentence level and to provide the ...

  9. THE UNIFICATION OF THE CODE LISTS PROVIDED WITHIN THE DATA MODEL ORIGINATING FROM THE INSPIRE TECHNICAL GUIDELINES AND THE ONES PROVIDED FOR GESUT DATABASES IN THE CONTEXT OF POTENTIAL EXPLOITATION IN THE MINING INDUSTRY

    Directory of Open Access Journals (Sweden)

    Andrzej ZYGMUNIAK

    2016-07-01

    Full Text Available This study is aimed at exposing differences between two data models in case of code lists values provided there. The first of them is an obligatory one for managing Geodesic Register of Utility Networks databases in Poland [9] and the second is the model originating from the Technical Guidelines issued to the INSPIRE Directive. Since the second one mentioned is the basis for managing spatial databases among European parties, correlating these two data models has an effect in easing the way of harmonizing and, in consequence, exchanging spatial data. Therefore, the study presents the possibilities of increasing compatibility between the values of the code lists concerning attributes for objects provid-ed in both models. In practice, it could lead to an increase of the competitiveness of entities managing or processing such databases and to greater involvement in scientific or research projects when it comes to the mining industry. More-over, since utility networks located on mining areas are under particular protection, the ability of making them more fitted to their own needs will make it possible for mining plants to exchange spatial data in a more efficient way.

  10. The Efficiency and Productivity Analysis of Large Logistics Providers Services in Korea

    Directory of Open Access Journals (Sweden)

    Hong Gyun Park

    2015-12-01

    Full Text Available In the fierce competition at the global logistics markets, Korean logistics providers were deemed more vulnerable than global logistics providers in terms of the quality and price competitiveness. To strengthen their competitiveness, logistics providers in Korea have focused on delivering integrated logistics services. In this regard, the Korean government has enacted the “Integrated Logistics Industry Certification Act” in 2006 to assist integrated logistics providers to offer logistics services based on their specialization and differentiation. It has been several years since the system was implemented, and the evaluation of the system implementation was necessary. Hence, in our study, we attempt to examine the efficiency and productivity of fourteen certified Korean logistics providers employing the DEA (Data Envelopment Analysis method with a five-year panel data since the inception of the Act. Through our static and dynamic analyses, We found that Pantos Logistics and HYUNDAI Glovis are running their businesses at the highest level of efficiency and Hanjin Transportation was the most stable company in their logistics operation.

  11. Characteristics of Adults Seeking Health Care Provider Support Facilitated by Mobile Technology: Secondary Data Analysis.

    Science.gov (United States)

    Bosak, Kelly; Park, Shin Hye

    2017-12-21

    Mobile health technology is rapidly evolving with the potential to transform health care. Self-management of health facilitated by mobile technology can maximize long-term health trajectories of adults. Little is known about the characteristics of adults seeking Web-based support from health care providers facilitated by mobile technology. This study aimed to examine the following: (1) the characteristics of adults who seek human support from health care providers for health concerns using mobile technology rather than from family members and friends or others with similar health conditions and (2) the use of mobile health technology among adults with chronic health conditions. Findings of this study were interpreted in the context of the Efficiency Model of Support. We first described characteristics of adults seeking Web-based support from health care providers. Using chi-square tests for categorical variables and t test for the continuous variable of age, we compared adults seeking Web-based and conventional support by demographics. The primary aim was analyzed using multivariate logistic regression to examine whether chronic health conditions and demographic factors (eg, sex, income, employment status, race, ethnicity, education, and age) were associated with seeking Web-based support from health care providers. The sample included adults (N=1453), the majority of whom were female 57.60% (837/1453), white 75.02% (1090/1453), and non-Hispanic 89.13% (1295/1453). The age of the participants ranged from 18 to 92 years (mean 48.6, standard deviation [SD] 16.8). The majority 76.05% (1105/1453) of participants reported college or higher level of education. A disparity was found in access to health care providers via mobile technology based on socioeconomic status. Adults with annual income of US $30,000 to US $100,000 were 1.72 times more likely to use Web-based methods to contact a health care provider, and adults with an annual income above US $100,000 were 2.41 to

  12. Transcriptome Analysis of Manganese-deficient Chlamydomonas reinhardtii Provides Insight on the Chlorophyll Biosynthesis Pathway

    Energy Technology Data Exchange (ETDEWEB)

    Lockhart, Ainsley; Zvenigorodsky, Natasha; Pedraza, Mary Ann; Lindquist, Erika

    2011-08-11

    The biosynthesis of chlorophyll and other tetrapyrroles is a vital but poorly understood process. Recent genomic advances with the unicellular green algae Chlamydomonas reinhardtii have created opportunity to more closely examine the mechanisms of the chlorophyll biosynthesis pathway via transcriptome analysis. Manganese is a nutrient of interest for complex reactions because of its multiple stable oxidation states and role in molecular oxygen coordination. C. reinhardtii was cultured in Manganese-deplete Tris-acetate-phosphate (TAP) media for 24 hours and used to create cDNA libraries for sequencing using Illumina TruSeq technology. Transcriptome analysis provided intriguing insight on possible regulatory mechanisms in the pathway. Evidence supports similarities of GTR (Glutamyl-tRNA synthase) to its Chlorella vulgaris homolog in terms of Mn requirements. Data was also suggestive of Mn-related compensatory up-regulation for pathway proteins CHLH1 (Manganese Chelatase), GUN4 (Magnesium chelatase activating protein), and POR1 (Light-dependent protochlorophyllide reductase). Intriguingly, data suggests possible reciprocal expression of oxygen dependent CPX1 (coproporphyrinogen III oxidase) and oxygen independent CPX2. Further analysis using RT-PCR could provide compelling evidence for several novel regulatory mechanisms in the chlorophyll biosynthesis pathway.

  13. Sustainable Water Infrastructure Asset Management: A Gap Analysis of Customer and Service Provider Perspectives

    Directory of Open Access Journals (Sweden)

    Sangjong Han

    2015-09-01

    Full Text Available The ultimate goal of urban water infrastructure asset management may be sustainable water supply with satisfaction for customers. In this work, we attempted to evaluate the gaps between the perspectives of customers and service providers in Korea’s water infrastructure asset management. To evaluate the customers’ perspective, a hierarchical questionnaire survey was conducted to estimate the weights of influence for six customer values and their attributes on Korean water utility management. To evaluate the service providers’ perspective, an AHP (Analytic Hierarchy Process analysis was performed to estimate the weights of influence for the customer values and their PIs (performance indicators. The gap analysis results show that customers place higher value on customer service satisfaction (emotion and information than do the service providers (managers, whereas the managers place more value on affordability than do the customers. The findings from this work imply that improving customer service is effective in satisfying the desirable water LOS (level of service for customers. Recommendations have also been provided for administrators and engineers to develop integrated decision-making systems that can reflect customer needs regarding the improvement of their water infrastructure asset management. The findings from this work may be helpful for the Korean government and water supply utilities in improving the sustainability of their water infrastructure asset management.

  14. What Happens When "Germs Don't Get Killed and They Attack Again and Again": Perceptions of Antimicrobial Resistance in the Context of Diarrheal Disease Treatment Among Laypersons and Health-Care Providers in Karachi, Pakistan.

    Science.gov (United States)

    Joseph, Heather A; Agboatwalla, Mubina; Hurd, Jacqueline; Jacobs-Slifka, Kara; Pitz, Adam; Bowen, Anna

    2016-07-06

    In south Asia, where diarrhea is common and antibiotics are accessible without prescription, antimicrobial resistance is an emerging and serious problem. However, beliefs and behaviors related to antimicrobial resistance are poorly understood. We explored laypersons' and health-care providers' (HCP) awareness and perceptions of antimicrobial resistance in the context of treatment of adult diarrheal disease in Karachi, Pakistan. In-depth, open-ended interviews were conducted with 40 laypersons and 45 HCPs in a lower-middle-class urban neighborhood. Interviews conducted in Urdu were audiotaped, transcribed, translated, and coded using applied thematic analysis. Slightly over half of laypersons and two-thirds of HCPs were aware that antimicrobial medication could lose effectiveness, but misperceptions were common. Laypersons and HCPs often believed that "the body becomes immune" or "bacteria attack more strongly" if medications are taken "improperly." Another prevalent theme was that causes and effects of antimicrobial resistance are limited to the individual taking the antimicrobial medication and to the specific diarrheal episode. Participants often attributed antimicrobial resistance to patient behaviors; HCP behavior was rarely discussed. Less than half of the HCPs were aware of treatment guidelines. To combat antimicrobial resistance in urban Pakistan, a health systems strategy and community-supported outreach campaigns on appropriate antimicrobial use are needed. © The American Society of Tropical Medicine and Hygiene.

  15. Website Analysis in an EFL Context: Content Comprehension, Perceptions on Web Usability and Awareness of Reading Strategies

    Science.gov (United States)

    Roy, Debopriyo; Crabbe, Stephen

    2015-01-01

    Website analysis is an interdisciplinary field of inquiry that focuses on both digital literacy and language competence (Brugger, 2009). Website analysis in an EFL learning context has the potential to facilitate logical thinking and in the process develop functional language proficiency. This study reported on an English language website…

  16. Offline analysis of context contribution to ERP-based typing BCI performance

    Science.gov (United States)

    Orhan, Umut; Erdogmus, Deniz; Roark, Brian; Oken, Barry; Fried-Oken, Melanie

    2013-12-01

    Objective. We aim to increase the symbol rate of electroencephalography (EEG) based brain-computer interface (BCI) typing systems by utilizing context information. Approach. Event related potentials (ERP) corresponding to a stimulus in EEG can be used to detect the intended target of a person for BCI. This paradigm is widely utilized to build letter-by-letter BCI typing systems. Nevertheless currently available BCI typing systems still require improvement due to low typing speeds. This is mainly due to the reliance on multiple repetitions before making a decision to achieve higher typing accuracy. Another possible approach to increase the speed of typing while not significantly reducing the accuracy of typing is to use additional context information. In this paper, we study the effect of using a language model (LM) as additional evidence for intent detection. Bayesian fusion of an n-gram symbol model with EEG features is proposed, and a specifically regularized discriminant analysis ERP discriminant is used to obtain EEG-based features. The target detection accuracies are rigorously evaluated for varying LM orders, as well as the number of ERP-inducing repetitions. Main results. The results demonstrate that the LMs contribute significantly to letter classification accuracy. For instance, we find that a single-trial ERP detection supported by a 4-gram LM may achieve the same performance as using 3-trial ERP classification for the non-initial letters of words. Significance. Overall, the fusion of evidence from EEG and LMs yields a significant opportunity to increase the symbol rate of a BCI typing system.

  17. Understanding the health of lorry drivers in context: A critical discourse analysis.

    Science.gov (United States)

    Caddick, Nick; Varela-Mato, Veronica; Nimmo, Myra A; Clemes, Stacey; Yates, Tom; King, James A

    2017-01-01

    This article moves beyond previous attempts to understand health problems in the lives of professional lorry drivers by placing the study of drivers' health in a wider social and cultural context. A combination of methods including focus groups, interviews and observations were used to collect data from a group of 24 lorry drivers working at a large transport company in the United Kingdom. Employing a critical discourse analysis, we identified the dominant discourses and subject positions shaping the formation of drivers' health and lifestyle choices. This analysis was systematically combined with an exploration of the gendered ways in which an almost exclusively male workforce talked about health. Findings revealed that drivers were constituted within a neoliberal economic discourse, which is reflective of the broader social structure, and which partly restricted drivers' opportunities for healthy living. Concurrently, drivers adopted the subject position of 'average man' as a way of defending their personal and masculine status in regards to health and to justify jettisoning approaches to healthy living that were deemed too extreme or irrational in the face of the constraints of their working lives. Suggestions for driver health promotion include refocusing on the social and cultural - rather than individual - underpinnings of driver health issues and a move away from moralistic approaches to health promotion.

  18. ANALYSIS OF THE INSOLVENCY OF ROMANIAN COMPANIES IN THE CONTEXT OF THE ECONOMIC CRISIS

    Directory of Open Access Journals (Sweden)

    Daniela CIOTINA

    2013-12-01

    Full Text Available This paper approaches an important topic in the field of insolvency, a present field, considering that bankruptcy threatens the development in good conditions of the activity of companies. Our approach concerns the analysis of the insolvency of Romanian trading companies in the context of the economic-financial crisis. Considering the current economic crisis, the problem of insolvency is very present. From an economic and financial perspective, insolvency is a reality of entrepreneurship, with a negative impact: it is conditioned and triggers inopportune and inappropriate management of the patrimony of economic units. Our aim is to perform a comparative analysis in time and space of the evaluation of the insolvency of trading companies, in order to grasp the common and specific elements in defining and presenting insolvency. In the practical part of the paper, for processing the data collected from the financial statements, we will use the SPSS software - Statistical Package for the Social Sciences. The database includes 30 insolvent companies in Romania, analyzed over a 5-year period. For a rigorous structure of the database, we will select the companies that perform their activity in several activity branches. The results of the research show the crisis that affects the analyzed Romanian companies.

  19. The ecocultural context and child behavior problems: A qualitative analysis in rural Nepal.

    Science.gov (United States)

    Burkey, Matthew D; Ghimire, Lajina; Adhikari, Ramesh Prasad; Wissow, Lawrence S; Jordans, Mark J D; Kohrt, Brandon A

    2016-06-01

    Commonly used paradigms for studying child psychopathology emphasize individual-level factors and often neglect the role of context in shaping risk and protective factors among children, families, and communities. To address this gap, we evaluated influences of ecocultural contextual factors on definitions, development of, and responses to child behavior problems and examined how contextual knowledge can inform culturally responsive interventions. We drew on Super and Harkness' "developmental niche" framework to evaluate the influences of physical and social settings, childcare customs and practices, and parental ethnotheories on the definitions, development of, and responses to child behavior problems in a community in rural Nepal. Data were collected between February and October 2014 through in-depth interviews with a purposive sampling strategy targeting parents (N = 10), teachers (N = 6), and community leaders (N = 8) familiar with child-rearing. Results were supplemented by focus group discussions with children (N = 9) and teachers (N = 8), pile-sort interviews with mothers (N = 8) of school-aged children, and direct observations in homes, schools, and community spaces. Behavior problems were largely defined in light of parents' socialization goals and role expectations for children. Certain physical settings and times were seen to carry greater risk for problematic behavior when children were unsupervised. Parents and other adults attempted to mitigate behavior problems by supervising them and their social interactions, providing for their physical needs, educating them, and through a shared verbal reminding strategy (samjhaune). The findings of our study illustrate the transactional nature of behavior problem development that involves context-specific goals, roles, and concerns that are likely to affect adults' interpretations and responses to children's behavior. Ultimately, employing a developmental niche framework will elucidate setting

  20. A nonparametric approach to medical survival data: Uncertainty in the context of risk in mortality analysis

    International Nuclear Information System (INIS)

    Janurová, Kateřina; Briš, Radim

    2014-01-01

    Medical survival right-censored data of about 850 patients are evaluated to analyze the uncertainty related to the risk of mortality on one hand and compare two basic surgery techniques in the context of risk of mortality on the other hand. Colorectal data come from patients who underwent colectomy in the University Hospital of Ostrava. Two basic surgery operating techniques are used for the colectomy: either traditional (open) or minimally invasive (laparoscopic). Basic question arising at the colectomy operation is, which type of operation to choose to guarantee longer overall survival time. Two non-parametric approaches have been used to quantify probability of mortality with uncertainties. In fact, complement of the probability to one, i.e. survival function with corresponding confidence levels is calculated and evaluated. First approach considers standard nonparametric estimators resulting from both the Kaplan–Meier estimator of survival function in connection with Greenwood's formula and the Nelson–Aalen estimator of cumulative hazard function including confidence interval for survival function as well. The second innovative approach, represented by Nonparametric Predictive Inference (NPI), uses lower and upper probabilities for quantifying uncertainty and provides a model of predictive survival function instead of the population survival function. The traditional log-rank test on one hand and the nonparametric predictive comparison of two groups of lifetime data on the other hand have been compared to evaluate risk of mortality in the context of mentioned surgery techniques. The size of the difference between two groups of lifetime data has been considered and analyzed as well. Both nonparametric approaches led to the same conclusion, that the minimally invasive operating technique guarantees the patient significantly longer survival time in comparison with the traditional operating technique

  1. Creating an Effective System of Education to Prepare Future Human Resources within the Context Provided by the Global Shift toward a "Green Economy"

    Science.gov (United States)

    Dudin, Mikhail Nikolaevich; Frolova, Evgenia Evgenevna; Kucherenko, Petr Aleksandrovich; Samusenko, Tatyana Mikhailovna; Voikova, Natalya Andreevna

    2016-01-01

    This article explores the major aspects of putting together effective national systems of education oriented toward providing academic instruction to the population and preparing future human resources for work within the economy in specific alignment with the concept of environmental responsibility (or that of "green economy"). The…

  2. The Combination of Coastal Resources Potential: Development of Windmill Techno Park in the Context of Edutourism and Hinterland Analysis

    Science.gov (United States)

    Hasanuddin, H.; Nurdin, H.; Waskito, W.; Refdinal, R.

    2018-04-01

    There are many coastal cities in Indonesia, among them the city of Padang and Pariaman in West Sumatra with the ownership of the grace of coastal resources, such as stunning coastal scenery and wind energy that can be converted to its potential. These two types of resources need to be combined utilization especially in relation to the development of tourism so as to have an impact on the regional development and the cities growth. This paper discusses of information related to the potential of coastal resources used as a parameter development of windmill techno park in the context of educational tourism. The discussion focuses on locational aspects and consideration of the design and modification for the windmill model to the enhancement of tourist attraction. In addition, it is also studying the presence of the windmill techno park as a development center in the context of hinterland in the regional analysis. Through the measurement results obtained average wind speed (2.5 - 6.5) m/s and meet the standards & criteria as a windmill design variables. While the geomorphology of the region, its location has a breathtaking coastal landscape as a tourist destination. Then through gravity analysis, the location of the windmill techno park development provides optimum strength to the growth of the city of Padang, with the value of interaction strength is higher than other regions. This means as a sub-urban area of the city the existence of windshield techno park later can support economic development and growth of cities around the coast.

  3. Thermal performance analysis of PCM in refrigerated container envelopes in the Italian context – Numerical modeling and validation

    International Nuclear Information System (INIS)

    Copertaro, Benedetta; Principi, Paolo; Fioretti, Roberto

    2016-01-01

    Highlights: • A refrigerated container with PCMs was evaluated in the Italian climatic context. • The numerical results were validated by an experimental campaign. • A 4.23% of mean bias was achieved comparing the numerical and experimental results. • PCMs application leads to a reduction in peak heat load of 20%. • An energy rate reduction of 4.65% was obtained in the PCMs added container. - Abstract: Due to external climatic conditions, radiation and temperature, refrigerated containers are subjected to high thermal stresses during storage in yards, warehouses, ships or during transport by rail or road. Moreover the consequent high thermal load has a great influence on both the electric and fuel energy consumption and on combined greenhouse gas emissions into the atmosphere. The aim of this research is the theoretical evaluation, using a previously validated Finite Element Method (FEM), of the related energy benefits deriving from the application of PCMs (Phase Change Materials) to a traditional refrigerated container envelope. Specifically the numerical analysis was performed for several kinds of PCMs, climatic conditions and exposures. The study also provides a numerical tool to be used in the prediction of the thermal performance of refrigerated container envelopes with PCM in the Italian context. An experimental analysis was carried out in order to test the accuracy of the numerical model and to validate it. Results show that PCM application to a 20’ ISO container envelope can reduce and shift the daily heat load phases with respect to a traditional envelope fitted only with insulating materials.

  4. Cytobank: providing an analytics platform for community cytometry data analysis and collaboration.

    Science.gov (United States)

    Chen, Tiffany J; Kotecha, Nikesh

    2014-01-01

    Cytometry is used extensively in clinical and laboratory settings to diagnose and track cell subsets in blood and tissue. High-throughput, single-cell approaches leveraging cytometry are developed and applied in the computational and systems biology communities by researchers, who seek to improve the diagnosis of human diseases, map the structures of cell signaling networks, and identify new cell types. Data analysis and management present a bottleneck in the flow of knowledge from bench to clinic. Multi-parameter flow and mass cytometry enable identification of signaling profiles of patient cell samples. Currently, this process is manual, requiring hours of work to summarize multi-dimensional data and translate these data for input into other analysis programs. In addition, the increase in the number and size of collaborative cytometry studies as well as the computational complexity of analytical tools require the ability to assemble sufficient and appropriately configured computing capacity on demand. There is a critical need for platforms that can be used by both clinical and basic researchers who routinely rely on cytometry. Recent advances provide a unique opportunity to facilitate collaboration and analysis and management of cytometry data. Specifically, advances in cloud computing and virtualization are enabling efficient use of large computing resources for analysis and backup. An example is Cytobank, a platform that allows researchers to annotate, analyze, and share results along with the underlying single-cell data.

  5. Analysis of the implications of the USSR providing reprocessing and MOX fabrication services to other countries

    International Nuclear Information System (INIS)

    1994-01-01

    This brief analysis, which is based on unclassified sources, seeks to identify what some of the implications would be if the Soviets started to move actively to try to provide reprocessing and MOX fabrication services to the US and other countries. While information on Soviet intentions is limited, it postulates that the Soviets would offer to reprocess spent LWR at competitive prices, fabricate the plutonium and reenrich the uranium, and sell these products back to the customer. Since it is not known whether they would insist on returning the waste from reprocessing or would be prepared to keep it, we comment briefly on what the implications of either of these actions might be

  6. SUS in nuclear medicine in Brazil: analysis and comparison of data provided by Datasus and CNEN.

    Science.gov (United States)

    Pozzo, Lorena; Coura Filho, George; Osso Júnior, João Alberto; Squair, Peterson Lima

    2014-01-01

    To investigate the outpatient access to nuclear medicine procedures by means of the Brazilian Unified Health System (SUS), analyzing the correspondence between data provided by this system and those from Comissão Nacional de Energia Nuclear (CNEN) (National Commission of Nuclear Energy). Data provided by Datasus regarding number of scintillation chambers, outpatient procedures performed from 2008 to 2012, administrative responsibility for such procedures, type of service providers and outsourced services were retrieved and evaluated. Also, such data were compared with those from institutions certified by CNEN. The present study demonstrated that the system still lacks maturity in terms of correct data input, particularly regarding equipment available. It was possible to list the most common procedures and check the growth of the specialty along the study period. Private centers are responsible for most of the procedures covered and reimbursed by SUS. However, many healthcare facilities are not certified by CNEN. Datasus provides relevant data for analysis as done in the present study, although some issues still require attention. The present study has quantitatively depicted the Brazilian reality regarding access to nuclear medicine procedures offered by/for SUS.

  7. SUS in nuclear medicine in Brazil: analysis and comparison of data provided by Datasus and CNEN*

    Science.gov (United States)

    Pozzo, Lorena; Coura Filho, George; Osso Júnior, João Alberto; Squair, Peterson Lima

    2014-01-01

    Objective To investigate the outpatient access to nuclear medicine procedures by means of the Brazilian Unified Health System (SUS), analyzing the correspondence between data provided by this system and those from Comissão Nacional de Energia Nuclear (CNEN) (National Commission of Nuclear Energy). Materials and Methods Data provided by Datasus regarding number of scintillation chambers, outpatient procedures performed from 2008 to 2012, administrative responsibility for such procedures, type of service providers and outsourced services were retrieved and evaluated. Also, such data were compared with those from institutions certified by CNEN. Results The present study demonstrated that the system still lacks maturity in terms of correct data input, particularly regarding equipment available. It was possible to list the most common procedures and check the growth of the specialty along the study period. Private centers are responsible for most of the procedures covered and reimbursed by SUS. However, many healthcare facilities are not certified by CNEN. Conclusion Datasus provides relevant data for analysis as done in the present study, although some issues still require attention. The present study has quantitatively depicted the Brazilian reality regarding access to nuclear medicine procedures offered by/for SUS. PMID:25741070

  8. Intramolecular 13C analysis of tree rings provides multiple plant ecophysiology signals covering decades.

    Science.gov (United States)

    Wieloch, Thomas; Ehlers, Ina; Yu, Jun; Frank, David; Grabner, Michael; Gessler, Arthur; Schleucher, Jürgen

    2018-03-22

    Measurements of carbon isotope contents of plant organic matter provide important information in diverse fields such as plant breeding, ecophysiology, biogeochemistry and paleoclimatology. They are currently based on 13 C/ 12 C ratios of specific, whole metabolites, but we show here that intramolecular ratios provide higher resolution information. In the glucose units of tree-ring cellulose of 12 tree species, we detected large differences in 13 C/ 12 C ratios (>10‰) among carbon atoms, which provide isotopically distinct inputs to major global C pools, including wood and soil organic matter. Thus, considering position-specific differences can improve characterisation of soil-to-atmosphere carbon fluxes and soil metabolism. In a Pinus nigra tree-ring archive formed from 1961 to 1995, we found novel 13 C signals, and show that intramolecular analysis enables more comprehensive and precise signal extraction from tree rings, and thus higher resolution reconstruction of plants' responses to climate change. Moreover, we propose an ecophysiological mechanism for the introduction of a 13 C signal, which links an environmental shift to the triggered metabolic shift and its intramolecular 13 C signature. In conclusion, intramolecular 13 C analyses can provide valuable new information about long-term metabolic dynamics for numerous applications.

  9. A CONTEXT AWARE BASED PRE-HANDOFF SUPPORT APPROACH TO PROVIDE OPTIMAL QOS FOR STREAMING APPLICATIONS OVER VEHICULAR AD HOC NETWORKS – HOSA

    Directory of Open Access Journals (Sweden)

    K. RAMESH BABU

    2015-06-01

    Full Text Available Large variations in network Quality of Service (QoS such as bandwidth, latency, jitter, and reliability may occur during media transfer over vehicular ad hoc networks (VANET. Usage of VANET over mobile and wireless computing applications experience “bursty” QoS behavior during the execution over distributed network scenarios. Applications such as streaming media services need to adapt their functionalities to any change in network status. Moreover, an enhanced software platform is necessary to provide adaptive network management services to upper software components. HOSA, a handoff service broker based architecture for QoS adaptation over VANET supports in providing awareness. HOSA is structured as a middleware platform both to provide QoS awareness to streaming applications as well to manage dynamic ad hoc network resources with support over handoff in an adaptive fashion. HOSA is well analyzed over routing schemes such as TIBSCRPH, SIP and ABSRP where performance of HOSA was measured using throughput, traffic intensity and end to end delay. HOSA has been analyzed using JXTA development toolkit over C++ implemented classes to demonstrate its performance over varying node mobility established using vehicular mobility based conference application.

  10. New Insights into the Phylogeny and Gene Context Analysis of Binder of Sperm Proteins (BSPs.

    Directory of Open Access Journals (Sweden)

    Edith Serrano

    Full Text Available Seminal plasma (SP proteins support the survival of spermatozoa acting not only at the plasma membrane but also by inhibition of capacitation, resulting in higher fertilizing ability. Among SP proteins, BSP (binder of sperm proteins are the most studied, since they may be useful for the improvement of semen diluents, storage and subsequent fertilization results. However, an updated and detailed phylogenetic analysis of the BSP protein superfamily has not been carried out with all the sequences described in the main databases. The update view shows for the first time an equally distributed number of sequences between the three families: BSP, and their homologs 1 (BSPH1 and 2 (BSPH2. The BSP family is divided in four subfamilies, BSP1 subfamily being the predominant, followed by subfamilies BSP3, BSP5 and BSP2. BSPH proteins were found among placental mammals (Eutheria belonging to the orders Proboscidea, Primates, Lagomorpha, Rodentia, Chiroptera, Perissodactyla and Cetartiodactyla. However, BSPH2 proteins were also found in the Scandentia order and Metatheria clade. This phylogenetic analysis, when combined with a gene context analysis, showed a completely new evolutionary scenario for the BSP superfamily of proteins with three defined different gene patterns, one for BSPs, one for BSPH1/BSPH2/ELSPBP1 and another one for BSPH1/BSPH2 without ELSPBP1. In addition, the study has permitted to define concise conserved blocks for each family (BSP, BSPH1 and BSPH2, which could be used for a more reliable assignment for the incoming sequences, for data curation of current databases, and for cloning new BSPs, as the one described in this paper, ram seminal vesicle 20 kDa protein (RSVP20, Ovis aries BSP5b.

  11. Agent-based organizational modelling for analysis of safety culture at an air navigation service provider

    International Nuclear Information System (INIS)

    Stroeve, Sybert H.; Sharpanskykh, Alexei; Kirwan, Barry

    2011-01-01

    Assessment of safety culture is done predominantly by questionnaire-based studies, which tend to reveal attitudes on immaterial characteristics (values, beliefs, norms). There is a need for a better understanding of the implications of the material aspects of an organization (structures, processes, etc.) for safety culture and their interactions with the immaterial characteristics. This paper presents a new agent-based organizational modelling approach for integrated and systematic evaluation of material and immaterial characteristics of socio-technical organizations in safety culture analysis. It uniquely considers both the formal organization and the value- and belief-driven behaviour of individuals in the organization. Results are presented of a model for safety occurrence reporting at an air navigation service provider. Model predictions consistent with questionnaire-based results are achieved. A sensitivity analysis provides insight in organizational factors that strongly influence safety culture indicators. The modelling approach can be used in combination with attitude-focused safety culture research, towards an integrated evaluation of material and immaterial characteristics of socio-technical organizations. By using this approach an organization is able to gain a deeper understanding of causes of diverse problems and inefficiencies both in the formal organization and in the behaviour of organizational agents, and to systematically identify and evaluate improvement options.

  12. Quality of services and quality of life from service providers' perspectives: analysis with focus groups.

    Science.gov (United States)

    Jenaro, C; Vega, V; Flores, N; Cruz, M

    2013-06-01

    Concepts such as support, quality of life and quality of services are customary in services for people with intellectual disabilities. The identification of the different ways of conceiving, prioritising and implementing these concepts by service providers can help to drive changes to achieve better personal outcomes for this population. The current study aims to identify service providers' perceptions regarding the quality of life of their clients and the quality of services they provide. It also aims to identify similarities and differences of appraisals among professionals, and to identify associations between supports, quality of life and quality of services. Data were collected from 22 service providers who attended three focus groups (professionals, direct support staff, and managers) from whom 424 comments were analysed. Service providers were asked about the required support for users, the meaning of quality of life for those users, and about features that should characterise quality services. Thematic analysis was employed and transcripts of the sessions were coded according to the dimensions of models on supports, quality of life and quality of services. Chi-squared tests were utilised to test for potential differences among groups. Each professional group has its own priorities concerning required supports. Among the organisation different and potentially conflicting perceptions regarding the meaning of experiencing quality of life coexist. Concerning quality of services, only managers mentioned personal outcomes. Finally, institutionalisation has a negative impact on supports, quality of life and quality of services. It is necessary to move beyond a shared awareness of the negative impact of institutionalisation towards the transformation of services in search of personal quality outcomes. © 2012 The Authors. Journal of Intellectual Disability Research © 2012 John Wiley & Sons Ltd, MENCAP & IASSID.

  13. Multi-omics analysis provides insight to the Ignicoccus hospitalis-Nanoarchaeum equitans association.

    Science.gov (United States)

    Rawle, Rachel A; Hamerly, Timothy; Tripet, Brian P; Giannone, Richard J; Wurch, Louie; Hettich, Robert L; Podar, Mircea; Copié, Valerie; Bothner, Brian

    2017-09-01

    Studies of interspecies interactions are inherently difficult due to the complex mechanisms which enable these relationships. A model system for studying interspecies interactions is the marine hyperthermophiles Ignicoccus hospitalis and Nanoarchaeum equitans. Recent independently-conducted 'omics' analyses have generated insights into the molecular factors modulating this association. However, significant questions remain about the nature of the interactions between these archaea. We jointly analyzed multiple levels of omics datasets obtained from published, independent transcriptomics, proteomics, and metabolomics analyses. DAVID identified functionally-related groups enriched when I. hospitalis is grown alone or in co-culture with N. equitans. Enriched molecular pathways were subsequently visualized using interaction maps generated using STRING. Key findings of our multi-level omics analysis indicated that I. hospitalis provides precursors to N. equitans for energy metabolism. Analysis indicated an overall reduction in diversity of metabolic precursors in the I. hospitalis-N. equitans co-culture, which has been connected to the differential use of ribosomal subunits and was previously unnoticed. We also identified differences in precursors linked to amino acid metabolism, NADH metabolism, and carbon fixation, providing new insights into the metabolic adaptions of I. hospitalis enabling the growth of N. equitans. This multi-omics analysis builds upon previously identified cellular patterns while offering new insights into mechanisms that enable the I. hospitalis-N. equitans association. Our study applies statistical and visualization techniques to a mixed-source omics dataset to yield a more global insight into a complex system, that was not readily discernable from separate omics studies. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. A blueprint-based case study analysis of nutrition services provided in a midterm care facility for the elderly.

    Science.gov (United States)

    Paquet, Catherine; St-Arnaud-Mckenzie, Danielle; Ferland, Guylaine; Dubé, Laurette

    2003-03-01

    Ensuring nutritionally adequate food intake in institutions is a complex and important challenge for dietitians. To tackle this problem, we argue that dietitians need to adopt a systematic, integrative, and patient-centered approach to identify and manage more effectively organizational determinants of the quality of food intake under their control. In this study, we introduce such an approach, the blueprint-based case study, that we applied in the context of a midterm care facility for elderly patients. Data gathered through interviews and field observations were used to develop, from the perspective of key patient encounters, detailed representations of the food, nutrition, and nursing activities necessary to ensure adequate food intake. These service "blueprints" were developed to illustrate all activities that might potentially impact on the nutritional, sensory, functional, and social quality of patients' meals. They were also used as roadmaps to develop a case study analysis in which critical areas were identified and opportunities for improvement put forth, while considering services' resources and priorities. By providing a precise, objective, yet comprehensive mapping of the service operations and management, the blueprint-based case study approach represents a valuable tool to determine the optimal allocation of resources to insure nutritionally adequate food intake to patients.

  15. Teachers implementing context-based teaching materials : a framework for case-analysis in chemistry

    NARCIS (Netherlands)

    Vos, M.A.J.; Taconis, R.; Jochems, W.M.G.; Pilot, A.

    2010-01-01

    We present a framework for analysing the interplay between context-based teaching material and teachers, and for evaluating the adequacy of the resulting implementation of context-based pedagogy in chemistry classroom practice. The development of the framework is described, including an account of

  16. Probabilistic cost-benefit analysis of disaster risk management in a development context.

    Science.gov (United States)

    Kull, Daniel; Mechler, Reinhard; Hochrainer-Stigler, Stefan

    2013-07-01

    Limited studies have shown that disaster risk management (DRM) can be cost-efficient in a development context. Cost-benefit analysis (CBA) is an evaluation tool to analyse economic efficiency. This research introduces quantitative, stochastic CBA frameworks and applies them in case studies of flood and drought risk reduction in India and Pakistan, while also incorporating projected climate change impacts. DRM interventions are shown to be economically efficient, with integrated approaches more cost-effective and robust than singular interventions. The paper highlights that CBA can be a useful tool if certain issues are considered properly, including: complexities in estimating risk; data dependency of results; negative effects of interventions; and distributional aspects. The design and process of CBA must take into account specific objectives, available information, resources, and the perceptions and needs of stakeholders as transparently as possible. Intervention design and uncertainties should be qualified through dialogue, indicating that process is as important as numerical results. © 2013 The Author(s). Journal compilation © Overseas Development Institute, 2013.

  17. Self-Determination Theory Applied to Health Contexts: A Meta-Analysis.

    Science.gov (United States)

    Ng, Johan Y Y; Ntoumanis, Nikos; Thøgersen-Ntoumani, Cecilie; Deci, Edward L; Ryan, Richard M; Duda, Joan L; Williams, Geoffrey C

    2012-07-01

    Behavior change is more effective and lasting when patients are autonomously motivated. To examine this idea, we identified 184 independent data sets from studies that utilized self-determination theory (SDT; Deci & Ryan, 2000) in health care and health promotion contexts. A meta-analysis evaluated relations between the SDT-based constructs of practitioner support for patient autonomy and patients' experience of psychological need satisfaction, as well as relations between these SDT constructs and indices of mental and physical health. Results showed the expected relations among the SDT variables, as well as positive relations of psychological need satisfaction and autonomous motivation to beneficial health outcomes. Several variables (e.g., participants' age, study design) were tested as potential moderators when effect sizes were heterogeneous. Finally, we used path analyses of the meta-analyzed correlations to test the interrelations among the SDT variables. Results suggested that SDT is a viable conceptual framework to study antecedents and outcomes of motivation for health-related behaviors. © The Author(s) 2012.

  18. The Sustainability Analysis Framework: An Effective Knowledge Communication Tool in a Whole of Government Context

    Directory of Open Access Journals (Sweden)

    Kendal Hodgman

    2007-06-01

    Full Text Available This paper focuses on the structural formation of the Sustainability Analysis Framework (SAF, which has proved to be an effective knowledge communication tool in the largest state administration in Australia, the Government of New South Wales. The SAF, devised by the author, has been implemented across thirty-eight state agencies and demonstrates that a whole of government Sustainability perspective is achievable. The level of the NSW Government's commitment to this process is evidenced by the fact that it was coordinated at the highest levels of the administration and engaged high-level input from a comprehensive portfolio of its agencies. The SAF's successful deployment across this significant bureaucracy shows that the generally applicable mechanism is effective in data collation, information sharing, knowledge organisation and the communication of Sustainability practice and wisdom. At the heart of the paper is the author's contention that one of the key problems which jeopardises our common future on Earth is the lack of effective tools to communicate Sustainability thinking and practice. In the course of the project, upon which this paper is based, the author identified the need for a visually and conceptually accessible mechanism to accelerate the uptake of Sustainability practice in a whole of organization context. In designing the SAF, which has successfully bridged this knowledge communication gap, the author employed two of humanity's fundamental learning tools – the diagram and the story.

  19. Analysis and Design of a Context Adaptable SAD/MSE Architecture

    Directory of Open Access Journals (Sweden)

    Arvind Sudarsanam

    2009-01-01

    Full Text Available Design of flexible multimedia accelerators that can cater to multiple algorithms is being aggressively pursued in the media processors community. Such an approach is justified in the era of sub-45 nm technology where an increasingly dominating leakage power component is forcing designers to make the best possible use of on-chip resources. In this paper we present an analysis of two commonly used window-based operations (sum of absolute differences and mean squared error across a variety of search patterns and block sizes (2×3, 5×5, etc.. We propose a context adaptable architecture that has (i configurable 2D systolic array and (ii 2D Configurable Register Array (CRA. CRA can cater to variable pixel access patterns while reusing fetched pixels across search windows. Benefits of proposed architecture when compared to 15 other published architectures are adaptability, high throughput, and low latency at a cost of increased footprint, when ported on a Xilinx FPGA.

  20. Insights on pumping well interpretation from flow dimension analysis: The learnings of a multi-context field database

    Science.gov (United States)

    Ferroud, Anouck; Chesnaux, Romain; Rafini, Silvain

    2018-01-01

    The flow dimension parameter n, derived from the Generalized Radial Flow model, is a valuable tool to investigate the actual flow regimes that really occur during a pumping test rather than suppose them to be radial, as postulated by the Theis-derived models. A numerical approach has shown that, when the flow dimension is not radial, using the derivative analysis rather than the conventional Theis and Cooper-Jacob methods helps to estimate much more accurately the hydraulic conductivity of the aquifer. Although n has been analysed in numerous studies including field-based studies, there is a striking lack of knowledge about its occurrence in nature and how it may be related to the hydrogeological setting. This study provides an overview of the occurrence of n in natural aquifers located in various geological contexts including crystalline rock, carbonate rock and granular aquifers. A comprehensive database is compiled from governmental and industrial sources, based on 69 constant-rate pumping tests. By means of a sequential analysis approach, we systematically performed a flow dimension analysis in which straight segments on drawdown-log derivative time series are interpreted as successive, specific and independent flow regimes. To reduce the uncertainties inherent in the identification of n sequences, we used the proprietary SIREN code to execute a dual simultaneous fit on both the drawdown and the drawdown-log derivative signals. Using the stated database, we investigate the frequency with which the radial and non-radial flow regimes occur in fractured rock and granular aquifers, and also provide outcomes that indicate the lack of applicability of Theis-derived models in representing nature. The results also emphasize the complexity of hydraulic signatures observed in nature by pointing out n sequential signals and non-integer n values that are frequently observed in the database.

  1. Visualizing context through theory deconstruction: a content analysis of three bodies of evaluation theory literature.

    Science.gov (United States)

    Vo, Anne T

    2013-06-01

    While the evaluation field collectively agrees that contextual factors bear on evaluation practice and related scholarly endeavors, the discipline does not yet have an explicit framework for understanding evaluation context. To address this gap in the knowledge base, this paper explores the ways in which evaluation context has been addressed in the practical-participatory, values-engaged, and emergent realist evaluation literatures. Five primary dimensions that constitute evaluation context were identified for this purpose: (1) stakeholder; (2) program; (3) organization; (4) historical/political; and (5) evaluator. Journal articles, book chapters, and conference papers rooted in the selected evaluation approaches were compared along these dimensions in order to explore points of convergence and divergence in the theories. Study results suggest that the selected prescriptive theories most clearly explicate stakeholder and evaluator contexts. Programmatic, organizational, and historical/political contexts, on the other hand, require further clarification. Copyright © 2012 Elsevier Ltd. All rights reserved.

  2. Shared Decision-Making in Oncology - A Qualitative Analysis of Healthcare Providers' Views on Current Practice.

    Science.gov (United States)

    Frerichs, Wiebke; Hahlweg, Pola; Müller, Evamaria; Adis, Christine; Scholl, Isabelle

    2016-01-01

    Despite an increased awareness of shared decision-making (SDM) and its prominent position on the health policy agenda, its implementation in routine care remains a challenge in Germany. In order to overcome this challenge, it is important to understand healthcare providers' views regarding SDM and to take their perspectives and opinions into account in the development of an implementation program. The present study aimed at exploring a) the attitudes of different healthcare providers regarding SDM in oncology and b) their experiences with treatment decisions in daily practice. A qualitative study was conducted using focus groups and individual interviews with different healthcare providers at the University Cancer Center Hamburg, Germany. Focus groups and interviews were audio-recorded, transcribed and analyzed using conventional content analysis and descriptive statistics. N = 4 focus groups with a total of N = 25 participants and N = 17 individual interviews were conducted. Attitudes regarding SDM varied greatly between the different participants, especially concerning the definition of SDM, the attitude towards the degree of patient involvement in decision-making and assumptions about when SDM should take place. Experiences on how treatment decisions are currently made varied. Negative experiences included time and structural constraints, and a lack of (multidisciplinary) communication. Positive experiences comprised informed patients, involvement of relatives and a good physician-patient relationship. The results show that German healthcare providers in oncology have a range of attitudes that currently function as barriers towards the implementation of SDM. Also, their experiences on how decision-making is currently done reveal difficulties in actively involving patients in decision-making processes. It will be crucial to take these attitudes and experiences seriously and to subsequently disentangle existing misconceptions in future implementation programs.

  3. What do providers want to know about opioid prescribing? A qualitative analysis of their questions.

    Science.gov (United States)

    Cushman, Phoebe A; Liebschutz, Jane M; Hodgkin, Joseph G; Shanahan, Christopher W; White, Julie L; Hardesty, Ilana; Alford, Daniel P

    2017-01-01

    In 2012, the US Food and Drug Administration (FDA) responded to the opioid crisis with a Risk Evaluation and Mitigation Strategy, requiring manufacturers of extended-release/long-acting opioids to fund continuing medical education based on the "FDA Blueprint for Prescriber Education." Topics in the Blueprint are "Assessing Patients for Treatment," "Initiating Therapy, Modifying Dosing, and Discontinuing Use," "Managing Therapy," "Counseling Patients and Caregivers about Safe Use," "General Drug Information," and "Specific Drug Information." Based on the FDA Blueprint, Boston University School of Medicine's "Safe and Competent Opioid Prescribing Education" (SCOPE of Pain) offers live trainings for physicians and other prescribers. During trainings, participants submit written questions about the curriculum and/or their clinical experiences. The objective was to compare themes that arose from questions asked by SCOPE of Pain participants with content of the FDA Blueprint in order to evaluate how well the Blueprint answers prescribers' concerns. The authors conducted qualitative analyses of all 1309 questions submitted by participants in 29 trainings across 16 states from May 2013 to May 2015, using conventional content analysis to code the questions. Themes that emerged from participants' questions were then compared with the Blueprint. Most themes fell into the topic categories of the Blueprint. Five main themes diverged: Participants sought information on (1) safe alternatives to opioids, (2) overcoming barriers to safe opioid prescribing, (3) government regulations of opioid prescribing, (4) the role of marijuana in opioid prescribing, and (5) maintaining a positive provider-patient relationship while prescribing opioids. In addition to learning the mechanics of safe opioid prescribing, providers want to understand government regulations and effective patient communication skills. Aware of the limitations of opioids in managing chronic pain, providers seek advice

  4. Pecuniary evaluation of provided service by local and global based dual-dimensional SDC and PSS2B in the context of deregulated power markets

    International Nuclear Information System (INIS)

    Shayeghi, H.; Hashemi, Y.

    2013-01-01

    Highlights: • Assessing the role and performance of SDC and PSS2B in deregulated power markets. • The profit allocation of WADC as an AS provider is involved in this work. • A dual-dimensional SDC scheme for UPFC is applied to damp the power system swings. • The high share of dual-dimensional SDC shows capability of it in enhancing security. - Abstract: The problem of profit allocation of Unified Power Flow Controller-Supplementary Damping Controller (UPFC-SDC) and accelerating power PSS model (PSS2B) is an important and update issue which has not been properly directed yet. The model of UPFC-SDC that has been used in this paper is a dual-dimensional controller that first dimension of control is resulted from local signals and the second dimension is covered by global signals as additional measuring data from appropriate remote network locations, where swings are well observable. Thus, in this paper the profit allocation of Wide Area Damping Controller (WADC) is also presented as an undefined problem in security subject of deregulated power system. Assuming control action by UPFC-SDC and WADC as an Ancillary Service (AS), the contribution of UPFC-SDC in stability enhancement is evaluated. It is important to appropriately choose a criterion to assess the performance of UPFC-SDC, so that a suitable allocation of profit can be achieved. The sum of deviations of damping ratios and real part of eigenvalues is selected as Oscillation Damping Criterion (ODC). Two scenarios for valuation of small signal stability as an AS provided by UPFC-SDC is considered. The first scenario without retuning of controllers and in the second scenario controllers is retuned due to response of the market situation. A multi-objective optimization approach based on ODC, generation costs and UPFC cost is considered and then Non-Dominated Sorting Genetic Algorithm-II (NSGA-II) is utilized for solving this problem. A two area four machine test power system is considered for investigation

  5. CLUSTER ANALYSIS OF TOTAL ASSETS PROVIDED BY BANKS FROM FOUR CONTINENTS

    Directory of Open Access Journals (Sweden)

    MIRELA CĂTĂLINA TÜRKEȘ

    2017-08-01

    Full Text Available The paper analysed the total assets in 2016 achieved by the strongest 96 banks from 4 continents: Europe, America, Asia and Africa. It aims to evaluate the level of total assets provided by banks in 2016 and continental banking markets degree of differentiation to determine the overall conditions of the banks. Methodologies used in this study are based on cluster and descriptives analysis. Data set was built based on informations reported by banks on total assets. The results indicate that most of total banking assets are found in Asia and the fewest in Africa. At the end of 2016, the top 16 global banks owned total assets of $ 30.19 trillion according to the data set contains cluster 1 and the centroid was (2.25, 2.11, 3.06, 0.01.

  6. Gly184 of the Escherichia coli cAMP receptor protein provides optimal context for both DNA binding and RNA polymerase interaction.

    Science.gov (United States)

    Hicks, Matt N; Gunasekara, Sanjiva; Serate, Jose; Park, Jin; Mosharaf, Pegah; Zhou, Yue; Lee, Jin-Won; Youn, Hwan

    2017-10-01

    The Escherichia coli cAMP receptor protein (CRP) utilizes the helix-turn-helix motif for DNA binding. The CRP's recognition helix, termed F-helix, includes a stretch of six amino acids (Arg180, Glu181, Thr182, Val183, Gly184, and Arg185) for direct DNA contacts. Arg180, Glu181 and Arg185 are known as important residues for DNA binding and specificity, but little has been studied for the other residues. Here we show that Gly184 is another F-helix residue critical for the transcriptional activation function of CRP. First, glycine was repeatedly selected at CRP position 184 for its unique ability to provide wild type-level transcriptional activation activity. To dissect the glycine requirement, wild type CRP and mutants G184A, G184F, G184S, and G184Y were purified and their in vitro DNA-binding activity was measured. G184A and G184F displayed reduced DNA binding, which may explain their low transcriptional activation activity. However, G184S and G184Y displayed apparently normal DNA affinity. Therefore, an additional factor is needed to account for the diminished transcriptional activation function in G184S and G184Y, and the best explanation is perturbations in their interaction with RNA polymerase. The fact that glycine is the smallest amino acid could not fully warrant its suitability, as shown in this study. We hypothesize that Gly184 fulfills the dual functions of DNA binding and RNA polymerase interaction by conferring conformational flexibility to the F-helix.

  7. Whole genome analysis of Leptospira licerasiae provides insight into leptospiral evolution and pathogenicity.

    Directory of Open Access Journals (Sweden)

    Jessica N Ricaldi

    Full Text Available The whole genome analysis of two strains of the first intermediately pathogenic leptospiral species to be sequenced (Leptospira licerasiae strains VAR010 and MMD0835 provides insight into their pathogenic potential and deepens our understanding of leptospiral evolution. Comparative analysis of eight leptospiral genomes shows the existence of a core leptospiral genome comprising 1547 genes and 452 conserved genes restricted to infectious species (including L. licerasiae that are likely to be pathogenicity-related. Comparisons of the functional content of the genomes suggests that L. licerasiae retains several proteins related to nitrogen, amino acid and carbohydrate metabolism which might help to explain why these Leptospira grow well in artificial media compared with pathogenic species. L. licerasiae strains VAR010(T and MMD0835 possess two prophage elements. While one element is circular and shares homology with LE1 of L. biflexa, the second is cryptic and homologous to a previously identified but unnamed region in L. interrogans serovars Copenhageni and Lai. We also report a unique O-antigen locus in L. licerasiae comprised of a 6-gene cluster that is unexpectedly short compared with L. interrogans in which analogous regions may include >90 such genes. Sequence homology searches suggest that these genes were acquired by lateral gene transfer (LGT. Furthermore, seven putative genomic islands ranging in size from 5 to 36 kb are present also suggestive of antecedent LGT. How Leptospira become naturally competent remains to be determined, but considering the phylogenetic origins of the genes comprising the O-antigen cluster and other putative laterally transferred genes, L. licerasiae must be able to exchange genetic material with non-invasive environmental bacteria. The data presented here demonstrate that L. licerasiae is genetically more closely related to pathogenic than to saprophytic Leptospira and provide insight into the genomic bases for

  8. Pediatric primary care providers' perspectives regarding hospital discharge communication: a mixed methods analysis.

    Science.gov (United States)

    Leyenaar, JoAnna K; Bergert, Lora; Mallory, Leah A; Engel, Richard; Rassbach, Caroline; Shen, Mark; Woehrlen, Tess; Cooperberg, David; Coghlin, Daniel

    2015-01-01

    Effective communication between inpatient and outpatient providers may mitigate risks of adverse events associated with hospital discharge. However, there is an absence of pediatric literature defining effective discharge communication strategies at both freestanding children's hospitals and general hospitals. The objectives of this study were to assess associations between pediatric primary care providers' (PCPs) reported receipt of discharge communication and referral hospital type, and to describe PCPs' perspectives regarding effective discharge communication and areas for improvement. We administered a questionnaire to PCPs referring to 16 pediatric hospital medicine programs nationally. Multivariable models were developed to assess associations between referral hospital type and receipt and completeness of discharge communication. Open-ended questions asked respondents to describe effective strategies and areas requiring improvement regarding discharge communication. Conventional qualitative content analysis was performed to identify emergent themes. Responses were received from 201 PCPs, for a response rate of 63%. Although there were no differences between referral hospital type and PCP-reported receipt of discharge communication (relative risk 1.61, 95% confidence interval 0.97-2.67), PCPs referring to general hospitals more frequently reported completeness of discharge communication relative to those referring to freestanding children's hospitals (relative risk 1.78, 95% confidence interval 1.26-2.51). Analysis of free text responses yielded 4 major themes: 1) structured discharge communication, 2) direct personal communication, 3) reliability and timeliness of communication, and 4) communication for effective postdischarge care. This study highlights potential differences in the experiences of PCPs referring to general hospitals and freestanding children's hospitals, and presents valuable contextual data for future quality improvement initiatives

  9. Allocating provider resources to diagnose and treat restless legs syndrome: a cost-utility analysis.

    Science.gov (United States)

    Padula, William V; Phelps, Charles E; Moran, Dane; Earley, Christopher

    2017-10-01

    Restless legs syndrome (RLS) is a neurological disorder that is frequently misdiagnosed, resulting in delays in proper treatment. The objective of this study was to analyze the cost-utility of training primary care providers (PCP) in early and accurate diagnosis of RLS. We used a Markov model to compare two strategies: one where PCPs received training to diagnose RLS (informed care) and one where PCPs did not receive training (standard care). This analysis was conducted from the US societal and health sector perspectives over one-year, five-year, and lifetime (50-year) horizons. Costs were adjusted to 2016 USD, utilities measured as quality-adjusted life-years (QALYs), and both measures were discounted annually at 3%. Cost, utilities, and probabilities for the model were obtained through a comprehensive review of literature. An incremental cost-effectiveness ratio (ICER) was calculated to interpret our findings at a willingness-to-pay threshold of $100,000/QALY. Univariate and multivariate analyses were conducted to test model uncertainty, in addition to calculating the expected value of perfect information. Providing training to PCPs to correctly diagnose RLS was cost-effective since it cost $2021 more and gained 0.44 QALYs per patient over the course of a lifetime, resulting in an ICER of $4593/QALY. The model was sensitive to the utility for treated and untreated RLS. The probabilistic sensitivity analysis revealed that at $100,000/QALY, informed care had a 65.5% probability of being cost-effective. A program to train PCPs to better diagnose RLS appears to be a cost-effective strategy for improving outcomes for RLS patients. Copyright © 2017 Elsevier B.V. All rights reserved.

  10. De Novo Assembly and Comparative Transcriptome Analysis Provide Insight into Lysine Biosynthesis in Toona sinensis Roem.

    Science.gov (United States)

    Zhang, Xia; Song, Zhenqiao; Liu, Tian; Guo, Linlin; Li, Xingfeng

    2016-01-01

    Toona sinensis Roem is a popular leafy vegetable in Chinese cuisine and is also used as a traditional Chinese medicine. In this study, leaf samples were collected from the same plant on two development stages and then used for high-throughput Illumina RNA-sequencing (RNA-Seq). 125,884 transcripts and 54,628 unigenes were obtained through de novo assembly. A total of 25,570 could be annotated with known biological functions, which indicated that the T. sinensis leaves and shoots were undergoing multiple developmental processes especially for active metabolic processes. Analysis of differentially expressed unigenes between the two libraries showed that the lysine biosynthesis was an enriched KEGG pathway, and candidate genes involved in the lysine biosynthesis pathway in T. sinensis leaves and shoots were identified. Our results provide a primary analysis of the gene expression files of T. sinensis leaf and shoot on different development stages and afford a valuable resource for genetic and genomic research on plant lysine biosynthesis.

  11. Systems analysis of transcriptional data provides insights into muscle's biological response to botulinum toxin.

    Science.gov (United States)

    Mukund, Kavitha; Mathewson, Margie; Minamoto, Viviane; Ward, Samuel R; Subramaniam, Shankar; Lieber, Richard L

    2014-11-01

    This study provides global transcriptomic profiling and analysis of botulinum toxin A (BoNT-A)-treated muscle over a 1-year period. Microarray analysis was performed on rat tibialis anterior muscles from 4 groups (n = 4/group) at 1, 4, 12, and 52 weeks after BoNT-A injection compared with saline-injected rats at 12 weeks. Dramatic transcriptional adaptation occurred at 1 week with a paradoxical increase in expression of slow and immature isoforms, activation of genes in competing pathways of repair and atrophy, impaired mitochondrial biogenesis, and increased metal ion imbalance. Adaptations of the basal lamina and fibrillar extracellular matrix (ECM) occurred by 4 weeks. The muscle transcriptome returned to its unperturbed state 12 weeks after injection. Acute transcriptional adaptations resemble denervated muscle with some subtle differences, but resolved more quickly compared with denervation. Overall, gene expression across time correlates with the generally accepted BoNT-A time course and suggests that the direct action of BoNT-A in skeletal muscle is relatively rapid. © 2014 Wiley Periodicals, Inc.

  12. Healthcare provider-led interventions to support medication adherence following ACS: a meta-analysis.

    Science.gov (United States)

    Crawshaw, Jacob; Auyeung, Vivian; Ashworth, Lucy; Norton, Sam; Weinman, John

    2017-01-01

    We conducted a systematic review and meta-analysis to determine the effectiveness of healthcare provider-led (HCPs) interventions to support medication adherence in patients with acute coronary syndrome (ACS). A systematic search of Cochrane Library, Medline, EMBASE, PsycINFO, Web of Science, IPA, CINAHL, ASSIA, OpenGrey, EthOS, WorldCat and PQDT was undertaken. Interventions were deemed eligible if they included adult ACS patients, were HCP-led, measured medication adherence and randomised participants to parallel groups. Intervention content was coded using the Behaviour Change Technique (BCT) Taxonomy and data were pooled for analysis using random-effects models. Our search identified 8870 records, of which 27 were eligible (23 primary studies). A meta-analysis (n=9735) revealed HCP-led interventions increased the odds of medication adherence by 54% compared to control interventions (k=23, OR 1.54, 95% CI 1.26 to 1.88, I 2 =57.5%). After removing outliers, there was a 41% increase in the odds of medication adherence with moderate heterogeneity (k=21, OR 1.41, 95% CI 1.21 to 1.65, I 2 =35.3%). Interventions that included phone contact yielded (k=12, OR 1.63, 95% CI 1.25 to 2.12, I 2 =32.0%) a larger effect compared to those delivered exclusively in person. A total of 32/93 BCTs were identified across interventions (mean=4.7, SD=2.2) with 'information about health consequences' (BCT 5.1) (19/23) the most common. HCP-led interventions for ACS patients appear to have a small positive impact on medication adherence. While we were able to identify BCTs among interventions, data were insufficient to determine the impact of particular BCTs on study effectiveness. CRD42016037706.

  13. Dual mobility cups provide biomechanical advantages in situations at risk for dislocation: a finite element analysis.

    Science.gov (United States)

    Terrier, Alexandre; Latypova, Adeliya; Guillemin, Maika; Parvex, Valérie; Guyen, Olivier

    2017-03-01

    Constrained devices, standard implants with large heads, and dual mobility systems have become popular options to manage instability after total hip arthroplasty (THA). Clinical results with these options have shown variable success rates and significant higher rates of aseptic loosening and mechanical failures with constrained implants. Literature suggests potential advantages of dual mobility, however little is known about its biomechanics. We present a comparative biomechanical study of a standard implant, a constrained implant, and a dual mobility system. A finite element analysis was developed to assess and compare these acetabular options with regard to the range of motion (ROM) to impingement, the angle of dislocation, the resistive torque, the volume of polyethylene (PE) with a stress above 80% of the elastic limit, and the interfacial cup/bone stress. Dual mobility implants provided the greatest ROM to impingement and allowed delaying subluxation and dislocation when compared to standard and constrained implants. Dual mobility also demonstrated the lowest resistive torque at subluxation while the constrained implant provided the greatest one. The lowest critical PE volume was observed with the dual mobility implant, and the highest stress at the interfaces was observed with the constrained implant. This study highlights the biomechanical advantages of dual mobility systems over constrained and standard implants, and is supported by the clinical results reported. Therefore, the use of dual mobility systems in situations at risk for instability should be advocated and constrained implants should be restricted to salvage situations.

  14. Respiratory care practitioners as primary providers of neonatal intubation in a community hospital: an analysis.

    Science.gov (United States)

    Noblett, K E; Meibalane, R

    1995-10-01

    Respiratory care practitioners (RCPs) serve as the primary providers of neonatal endotracheal intubation (ETI) in our institution. ETIs are performed by registered respiratory therapists who have completed Pediatric Advanced Life Support and Neonatal Advanced Life Support training and have successfully completed 3 intubations under the direct supervision of a senior therapist. The purpose of this study was to (1) ascertain whether RCPs can successfully provide this type of service with acceptable complications rates and (2) survey the economic impact of this practice on patient charges in our hospital. An analysis of each intubation event in which an RCP participated was collected and compiled over a 5-month period (9-94 to 2-95). Calculations were made of the success rate and complications. A total of 38 ETIs were performed by the RCPs. Of these, 37 (97.4%) were performed with neonatal ETI at a Level-II nursery in a community hospital, and this practice may result in a cost reduction.

  15. Left alone--Swedish nurses' and mental health workers' experiences of being care providers in a social psychiatric dwelling context in the post-health-care-restructuring era. A focus-group interview study.

    Science.gov (United States)

    Kristiansen, Lisbeth; Hellzén, Ove; Asplund, Kenneth

    2010-09-01

    The professional role of nurses and mental health workers in social psychiatry is being re-defined towards a recovery, client-focused perspective. Approximately 0.7 percent of the adult population in Sweden suffers from severe mental illness leading to a need for community services. The primary aims of the Mental Health Reform in 1995 in Sweden were to improve the quality of life for people with severe, long-term mental illness and, through normalization and integration, enhancing their opportunities to communicate with and participate in society. This study examines nurses' and mental health workers' views and experiences of being care providers in a municipal psychiatric group dwelling context when caring for clients suffering from severe mental illness. Three focus group interviews were made and thematic content analysis was conducted. Four themes were formulated: 'Being a general human factotum not unlike the role of parents', 'Having a complex and ambiguous view of clients', 'Working in a mainly 'strangled' situation', and 'Feeling overwhelming frustration'. The staff, for instance, experienced a heavy workload that highly involved themselves as persons and restricted organization. The individual relational aspects of the nursing role, the risk of instrumentalizing the staff due to an organizational economical teleopathy (meaning a pathological desire to react goals), and the high societal demands on accomplishing the Mental Health Reform goals are discussed. To redefine the professional role of nurses and mental health workers in the community, in Sweden known as municipality, they need support in the form of continuously education, supervision, and dialogue with politicians as well as the public in general. © 2010 The Authors. Journal compilation © 2010 Nordic College of Caring Science.

  16. Morphological Analysis in Context versus Isolation: Use of a Dynamic Assessment Task with School-Age Children

    Science.gov (United States)

    Ram, Gayatri; Marinellie, Sally A.; Benigno, Joann; McCarthy, John

    2013-01-01

    Purpose: The current study investigated the ability of typically developing children in Grades 3 and 5 to use morphological analysis to determine the meanings of derived words with and without context clues. Also of interest was the relation between children's reading practices and their performance in determining the meanings of derived words.…

  17. A Latent Class Growth Analysis of School Bullying and Its Social Context: The Self-Determination Theory Perspective

    Science.gov (United States)

    Lam, Shui-fong; Law, Wilbert; Chan, Chi-Keung; Wong, Bernard P. H.; Zhang, Xiao

    2015-01-01

    The contribution of social context to school bullying was examined from the self-determination theory perspective in this longitudinal study of 536 adolescents from 3 secondary schools in Hong Kong. Latent class growth analysis of the student-reported data at 5 time points from grade 7 to grade 9 identified 4 groups of students: bullies (9.8%),…

  18. THE ANALYSIS OF COMPETITIVENESS IN THE TOURISM SECTOR IN THE ACTUAL CONTEXT OF ECONOMIC CRISIS

    Directory of Open Access Journals (Sweden)

    Vasile ROBU

    2009-06-01

    Full Text Available The past few years have witnessed many storms in the Tourism sector. Under the influence of an extremely volatile world economy (financial crisis, commodity and oil price rises, sharp exchange rate fluctuations, increase terrorism acts in several region with tourism potential Tourism demand slowed significantly. Yet, despite the current difficulties, the Tourism sector remains a critical economic sector worldwide and one that provides significant potential for economic growth and development internationally. A growing national Tourism sector contributes to raises national income, employment, and can improve a country's balance of payments. The sector is thus an important driver of growth and prosperity and,  within developing countries, it can play a leading role in poverty reduction. Despite the overall importance of developing the Tourism sector, many obstacles at the national level continue to hinder its development. This analysis aims to serve two purposes. First, we intend to provide useful comparative information for making decisions related to business and tourism development. Second, and more importantly, we hope that the analysis provides an opportunity for the Tourism industry to highlight the obstacles to Tourism competitiveness.

  19. Understanding the social context of fatal road traffic collisions among young people: a qualitative analysis of narrative text in coroners' records.

    Science.gov (United States)

    Pilkington, Paul; Bird, Emma; Gray, Selena; Towner, Elizabeth; Weld, Sarah; McKibben, Mary-Ann

    2014-01-24

    Deaths and injuries on the road remain a major cause of premature death among young people across the world. Routinely collected data usually focuses on the mechanism of road traffic collisions and basic demographic data of those involved. This study aimed to supplement these routine sources with a thematic analysis of narrative text contained in coroners' records, to explore the wider social context in which collisions occur. Thematic analysis of narrative text from Coroners' records, retrieved from thirty-four fatalities among young people (16-24 year olds) occurring as a result of thirty road traffic collisions in a rural county in the south of England over the period 2005-2010. Six key themes emerged: social driving, driving experience, interest in motor vehicles, driving behaviour, perception of driving ability, and emotional distress. Social driving (defined as a group of related behaviours including: driving as a social event in itself (i.e. without a pre-specified destination); driving to or from a social event; driving with accompanying passengers; driving late at night; driving where alcohol or drugs were a feature of the journey) was identified as a common feature across cases. Analysis of the wider social context in which road traffic collisions occur in young people can provide important information for understanding why collisions happen and developing targeted interventions to prevent them. It can complement routinely collected data, which often focuses on events immediately preceding a collision. Qualitative analysis of narrative text in coroner's records may provide a way of providing this type of information. These findings provide additional support for the case for Graduated Driver Licensing programmes to reduce collisions involving young people, and also suggest that road safety interventions need to take a more community development approach, recognising the importance of social context and focusing on social networks of young people.

  20. Sustainable transportation according to certification systems: A viability analysis based on neighborhood size and context relevance

    International Nuclear Information System (INIS)

    Gouda, Amr Ah.; Masoumi, Houshmand E.

    2017-01-01

    Urban sustainability certification (USC) systems comprehensively assess and benchmark the sustainability of neighborhoods, communities, etc. However, it is important to understand what USCs mean by neighborhoods and communities in terms of definition and their certified developments' size. This study focuses on sustainable transportation and its measures in USCs in order to discern: how relevant are these measures to the varied local conditions, especially in developing countries? And whether they can generate palpable benefits vis-à-vis the certified developments' site areas. Taking descriptive analysis methods, this study focuses on four prominent USCs, namely, LEED for Neighborhood Development, BREEAM Communities, CASBEE for Urban Development, and The Pearl Community Rating System. The four USCs prescribed multiple measures for sustainable transportation, particularly in favor of active transportation and public transportation. However, the relatively small size of their citified developments and the varying transportation conditions among different contexts attenuate the viability and relevance of the advocated measures for both modes. In order to yield more benefits, USCs should underscore the integrative nature of neighborhoods and communities, and transportation within their prescribed criteria and measures. Moreover, sustainable transportation as a theme should be tailored to the local conditions rather than being adopted or adapted from global USCs. - Highlights: • Transportation measures in four prominent certification systems were investigated. • Most certified neighborhoods, communities and developments have small site areas. • Certifications are insensitive to realities of transport in developing countries. • Benefits from advocating active transport only within certified areas are minimal. • Certifications devalue the integrative nature of neighborhoods and transportation.

  1. Sustainable transportation according to certification systems: A viability analysis based on neighborhood size and context relevance

    Energy Technology Data Exchange (ETDEWEB)

    Gouda, Amr Ah., E-mail: amr.gouda@eng.asu.edu.eg [Center for Technology and Society, Technische Universität Berlin, Hardenbergstr, 16-18, Berlin 10623 (Germany); Architecture Department, Faculty of Engineering, Ain Shams University, 1 Sarayat St., Abassia, Cairo (Egypt); Masoumi, Houshmand E. [Center for Technology and Society, Technische Universität Berlin, Hardenbergstr, 16-18, Berlin 10623 (Germany)

    2017-03-15

    Urban sustainability certification (USC) systems comprehensively assess and benchmark the sustainability of neighborhoods, communities, etc. However, it is important to understand what USCs mean by neighborhoods and communities in terms of definition and their certified developments' size. This study focuses on sustainable transportation and its measures in USCs in order to discern: how relevant are these measures to the varied local conditions, especially in developing countries? And whether they can generate palpable benefits vis-à-vis the certified developments' site areas. Taking descriptive analysis methods, this study focuses on four prominent USCs, namely, LEED for Neighborhood Development, BREEAM Communities, CASBEE for Urban Development, and The Pearl Community Rating System. The four USCs prescribed multiple measures for sustainable transportation, particularly in favor of active transportation and public transportation. However, the relatively small size of their citified developments and the varying transportation conditions among different contexts attenuate the viability and relevance of the advocated measures for both modes. In order to yield more benefits, USCs should underscore the integrative nature of neighborhoods and communities, and transportation within their prescribed criteria and measures. Moreover, sustainable transportation as a theme should be tailored to the local conditions rather than being adopted or adapted from global USCs. - Highlights: • Transportation measures in four prominent certification systems were investigated. • Most certified neighborhoods, communities and developments have small site areas. • Certifications are insensitive to realities of transport in developing countries. • Benefits from advocating active transport only within certified areas are minimal. • Certifications devalue the integrative nature of neighborhoods and transportation.

  2. Genome-wide analysis of Pax8 binding provides new insights into thyroid functions

    Directory of Open Access Journals (Sweden)

    Ruiz-Llorente Sergio

    2012-04-01

    Full Text Available Abstract Background The transcription factor Pax8 is essential for the differentiation of thyroid cells. However, there are few data on genes transcriptionally regulated by Pax8 other than thyroid-related genes. To better understand the role of Pax8 in the biology of thyroid cells, we obtained transcriptional profiles of Pax8-silenced PCCl3 thyroid cells using whole genome expression arrays and integrated these signals with global cis-regulatory sequencing studies performed by ChIP-Seq analysis Results Exhaustive analysis of Pax8 immunoprecipitated peaks demonstrated preferential binding to intragenic regions and CpG-enriched islands, which suggests a role of Pax8 in transcriptional regulation of orphan CpG regions. In addition, ChIP-Seq allowed us to identify Pax8 partners, including proteins involved in tertiary DNA structure (CTCF and chromatin remodeling (Sp1, and these direct transcriptional interactions were confirmed in vivo. Moreover, both factors modulate Pax8-dependent transcriptional activation of the sodium iodide symporter (Nis gene promoter. We ultimately combined putative and novel Pax8 binding sites with actual target gene expression regulation to define Pax8-dependent genes. Functional classification suggests that Pax8-regulated genes may be directly involved in important processes of thyroid cell function such as cell proliferation and differentiation, apoptosis, cell polarity, motion and adhesion, and a plethora of DNA/protein-related processes. Conclusion Our study provides novel insights into the role of Pax8 in thyroid biology, exerted through transcriptional regulation of important genes involved in critical thyrocyte processes. In addition, we found new transcriptional partners of Pax8, which functionally cooperate with Pax8 in the regulation of thyroid gene transcription. Besides, our data demonstrate preferential location of Pax8 in non-promoter CpG regions. These data point to an orphan CpG island-mediated mechanism

  3. Comparative proteomic analysis provides new insights into cadmium accumulation in rice grain under cadmium stress

    Energy Technology Data Exchange (ETDEWEB)

    Xue, Dawei, E-mail: dwxue@hznu.edu.cn [College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou 310036 (China); State Key Laboratory of Rice Biology, China National Rice Research Institute, Hangzhou 310006 (China); Jiang, Hua [State Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control, Zhejiang Academy of Agricultural Science, Hangzhou 310021 (China); Deng, Xiangxiong; Zhang, Xiaoqin [College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou 310036 (China); Wang, Hua [State Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control, Zhejiang Academy of Agricultural Science, Hangzhou 310021 (China); Xu, Xiangbin [College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou 310036 (China); Hu, Jiang; Zeng, Dali [State Key Laboratory of Rice Biology, China National Rice Research Institute, Hangzhou 310006 (China); Guo, Longbiao, E-mail: guolongbiao@caas.cn [State Key Laboratory of Rice Biology, China National Rice Research Institute, Hangzhou 310006 (China); Qian, Qian, E-mail: qianqian188@hotmail.com [College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou 310036 (China); State Key Laboratory of Rice Biology, China National Rice Research Institute, Hangzhou 310006 (China)

    2014-09-15

    Graphical abstract: - Highlights: • Cd is the most toxic heavy metal and is a major pollutant in rice grains. • The mechanism of Cd accumulation in rice grains has not been well demonstrated. • Proteomics analysis is carried out and the verification is implemented by QPCR. • Proteins associated with ROS and photosynthesis showed large variation in expression. - Abstract: Rice is one of the most important staple crops. During the growth season, rice plants are inevitably subjected to numerous stresses, among which heavy metal stress represented by cadmium contamination not only hindering the yield of rice but also affecting the food safety by Cd accumulating in rice grains. The mechanism of Cd accumulation in rice grains has not been well elucidated. In this study, we compare the proteomic difference between two genotypes with different Cd accumulation ability in grains. Verification of differentially expressed protein-encoding genes was analyzing by quantitative PCR (QPCR) and reanalysis of microarray expression data. Forty-seven proteins in total were successfully identified through proteomic screening. GO and KEGG enrichment analysis showed Cd accumulation triggered stress-related pathways in the cells, and strongly affecting metabolic pathways. Many proteins associated with nutrient reservoir and starch-related enzyme were identified in this study suggesting that a considerably damage on grain quality was caused. The results also implied stress response was initiated by the abnormal cells and the transmission of signals may mediated by reactive oxygen species (ROS). Our research will provide new insights into Cd accumulation in rice grain under Cd stress.

  4. Stable Isotope Analysis Reveals That Agricultural Habitat Provides an Important Dietary Component for Nonbreeding Dunlin

    Directory of Open Access Journals (Sweden)

    Lesley Joan Evans Ogden

    2005-12-01

    Full Text Available Although shorebirds spending the winter in temperate areas frequently use estuarine and supratidal (upland feeding habitats, the relative contribution of each habitat to individual diets has not been directly quantified. We quantified the proportional use that Calidris alpina pacifica (Dunlin made of estuarine vs. terrestrial farmland resources on the Fraser River Delta, British Columbia, using stable isotope analysis (δ13C, δ15N of blood from 268 Dunlin over four winters, 1997 through 2000. We tested for individual, age, sex, morphological, seasonal, and weather-related differences in dietary sources. Based on single- (δ13C and dual-isotope mixing models, the agricultural habitat contributed approximately 38% of Dunlin diet averaged over four winters, with the balance from intertidal flats. However, there was a wide variation among individuals in the extent of agricultural feeding, ranging from about 1% to 95% of diet. Younger birds had a significantly higher terrestrial contribution to diet (43% than did adults (35%. We estimated that 6% of adults and 13% of juveniles were obtaining at least 75% of their diet from terrestrial sources. The isotope data provided no evidence for sex or overall body size effects on the proportion of diet that is terrestrial in origin. The use of agricultural habitat by Dunlin peaked in early January. Adult Dunlin obtained a greater proportion of their diet terrestrially during periods of lower temperatures and high precipitation, whereas no such relationship existed for juveniles. Seasonal variation in the use of agricultural habitat suggests that it is used more during energetically stressful periods. The terrestrial farmland zone appears to be consistently important as a habitat for juveniles, but for adults it may provide an alternative feeding site used as a buffer against starvation during periods of extreme weather. Loss or reduction of agricultural habitat adjacent to estuaries may negatively impact

  5. An observational analysis of provider adherence to AUA guidelines on the management of benign prostatic hyperplasia.

    Science.gov (United States)

    Auffenberg, Gregory B; Gonzalez, Chris M; Wolf, J Stuart; Clemens, J Quentin; Meeks, William; McVary, Kevin T

    2014-11-01

    We retrospectively evaluated urologist adherence to the AUA guidelines on the management of new patients with benign prostatic hyperplasia related lower urinary tract symptoms in a large university urology group. All first time benign prostatic hyperplasia/lower urinary tract symptom visits to the urology clinic at the Northwestern Medical Faculty Foundation between January 1, 2008 and December 31, 2012 were evaluated using an institutionally managed electronic medical record data repository. Clinical documentation and orders from each encounter were assessed to determine the rate of performance of guideline measures. Approximately 1% of all results were manually reviewed in a validation process designed to determine the reliability of the electronic medical record based system. A total of 3,494 eligible encounters were evaluated in the final analysis. Provider adherence rates with the 9 measures recommended in the guidelines varied by measure from 53.0% to 92.8%. The rate of performance of 5 not routinely recommended measures was 10.2% or less. Post-void residual and urinary flow measurement were optional measures, and were performed on 68.1% and 4.6% of new encounters respectively. Manual validation revealed the electronic medical record data extraction was concordant with manual review in 96.7% of cases (95% CI 94.8-98.5). Using electronic medical record based data extraction techniques, we reliably document a baseline adherence rate with AUA guidelines on the management of benign prostatic hyperplasia. Establishing this benchmark will be important for future investigation into patient outcomes related to guideline adherence and into methods for improving provider adherence. Copyright © 2014 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

  6. A descriptive analysis of psychological traits among the health-care providers

    Directory of Open Access Journals (Sweden)

    Farah Ahmed

    2017-01-01

    Full Text Available Objective: The objective of this study is to access various personality traits of doctors of hospital subspecialties. Introduction: One of the most common perceptions in our society is that of medicine being a very stressful profession. The demands of practicing medicine can have significant effects on general health, work satisfaction, professional, and nonprofessional life. To increase the profitability, organizations curtail the staff to reduce the costs. Hence, it can be argued that doctors are subjected to extreme amounts psychiatric duress. Methodology: A descriptive study was conducted in a tertiary care hospital. In which one hundred and twenty-one doctors were approached randomly varying from different specialties. The short form of the psychopathic personality inventory (PPI-SF was used as a questionnaire. Results: One hundred and one (81 females and 20 males doctors from various specialties responded and completed the PPI-SF questionnaire. The subspecialty analysis of the doctors' responses was subdivided into pediatrics, gynecology, medical specialties, surgery, anesthetics, and radiology. Surgeons and GyneObs were the highest scorers on the PPI-SF, with scores of 138 and 149, respectively. Conclusion: This study showed that doctors score higher on a scale of psychopathic personality than the general population. This study also showed that stress immunity is the overriding personality trait in doctors which may, in turn, facilitate better overall patient care. Stress immunity may better facilitate empathy in certain acute situations, which plays a vital role in being a proficient doctor and providing satisfactory patient care and counseling.

  7. Comparative proteomic analysis provides insight into 10-hydroxy-2-decenoic acid biosynthesis in honey bee workers.

    Science.gov (United States)

    Yang, Xiao-Hui; Yang, Shi-Fa; Wang, Rui-Ming

    2017-07-01

    10-Hydroxy-2-decenoic acid (10-HDA) is the major compound produced from the mandibular glands (MGs) of honey bee workers. However, little information is available on the molecular mechanisms of 10-HDA biosynthesis. In our study, based on investigating the 10-HDA secretion pattern and the morphological characteristics of MGs from honey bee workers of different ages, a comparative proteomic analysis was performed in the MGs of workers with different 10-HDA production. In total, 59 up-regulated protein species representing 45 unique proteins were identified in high 10-HDA-producing workers by 2-DE-MALDI-TOF/TOF MS. These proteins were involved in carbohydrate/energy metabolism, fatty acid metabolism, protein metabolism and folding, antioxidation, cytoskeleton, development and cell signaling. Proteins related to fatty acid metabolism, including fatty acid synthase and β-oxidation enzymes, are potentially crucial proteins involved in 10-HDA biosynthesis pathway. And RNA interference (RNAi) results demonstrated that knockdown of electron transfer flavoprotein subunit beta (ETF-β), one of the protein related to fatty acid metabolism, decreased 10-HDA production of worker bees, suggesting that ETF-β was necessary for 10-HDA biosynthesis. This study reveals the characteristics of MGs of worker bees at different developmental stages and proteins associated with 10-HDA biosynthesis, which provides the first insight into the molecular mechanism of 10-HDA biosynthesis.

  8. Analysis of All Inclusive System Applied by the Accommodation Businesses in Turkey in the Context of Target Costing

    OpenAIRE

    Durmus Acar; Hasan Senol

    2014-01-01

    That the accommodation managements could sustain their existences operating in a competition in which the sale price of services they provide is ascertained show parallelism with controls of their costs. In this context, accommodation managements should provide demands and expectations of customers with low cost, short time and high quality targets by realizing at the same time and level. That’s why, they have focused on target cost (TC) method which aims to present on cost level that actuali...

  9. Cloud hosting of the IPython Notebook to Provide Collaborative Research Environments for Big Data Analysis

    Science.gov (United States)

    Kershaw, Philip; Lawrence, Bryan; Gomez-Dans, Jose; Holt, John

    2015-04-01

    We explore how the popular IPython Notebook computing system can be hosted on a cloud platform to provide a flexible virtual research hosting environment for Earth Observation data processing and analysis and how this approach can be expanded more broadly into a generic SaaS (Software as a Service) offering for the environmental sciences. OPTIRAD (OPTImisation environment for joint retrieval of multi-sensor RADiances) is a project funded by the European Space Agency to develop a collaborative research environment for Data Assimilation of Earth Observation products for land surface applications. Data Assimilation provides a powerful means to combine multiple sources of data and derive new products for this application domain. To be most effective, it requires close collaboration between specialists in this field, land surface modellers and end users of data generated. A goal of OPTIRAD then is to develop a collaborative research environment to engender shared working. Another significant challenge is that of data volume and complexity. Study of land surface requires high spatial and temporal resolutions, a relatively large number of variables and the application of algorithms which are computationally expensive. These problems can be addressed with the application of parallel processing techniques on specialist compute clusters. However, scientific users are often deterred by the time investment required to port their codes to these environments. Even when successfully achieved, it may be difficult to readily change or update. This runs counter to the scientific process of continuous experimentation, analysis and validation. The IPython Notebook provides users with a web-based interface to multiple interactive shells for the Python programming language. Code, documentation and graphical content can be saved and shared making it directly applicable to OPTIRAD's requirements for a shared working environment. Given the web interface it can be readily made into a hosted

  10. An Analysis of the Agency and Providence in Platonic, Aristotelian and Avicennan Metaphysics

    Directory of Open Access Journals (Sweden)

    Vahideh Hadad

    2013-12-01

    Full Text Available The questions as to whether the cosmic order of this world is based on action/agent or not? And if an agent is involved and the world and what it contains have to be seen as action, could we declare the cosmic order a providential order? are among the problems which have always occupied the mind of philosophers.      Reading through Platonic corpse leads us to the conclusion that he has founded his metaphysics upon the very idea of world of ideas. According to his works and words, Plato is a proponent of the theory of ideas. As a matter of fact, Plato's metaphysics lies in the theory of ideas. Plato illustrates the general makeup of the world of ideas and the way sensible objects stand in relation with the beings dwelling in the latter world by the well-known cave allegory in the seventh book of Republic. In his view, whatever we find around ourselves not only are not authentic realities but rather they are merely shadows of the truth. Every phenomenon has an essence or reality which is known as its form. The idea of Good overshadows the other ideas insofar as these latter ideas or forms are seen as the effects of the former. It seems we can take God, the One, Absolute Good, Absolute Beauty and Good in itself as expressions of the same reality which Plato has used in different contexts through his works. Along these terms some other notions have also been brought up like intellect, divine intellect, Demiurge, ideas and the particulars of material world. By explaining Plato's taking of these notions and terms, we believe, one can discover Platonic ontological system.    In Republic, Plato argues that God is the creator of ideal bed and all other things, and he is the creator of intelligible entities (ideas. The One or reality as a whole not only contains ideas but the spirit too. The One is the final principle and the source of ideas and is beyond all human attributes. Having said these, it is not clear how reason gets itself related to the

  11. An Analysis of the Agency and Providence in Platonic, Aristotelian and Avicennan Metaphysics

    Directory of Open Access Journals (Sweden)

    S. Mahdi Emamijomeh

    2014-01-01

    Full Text Available The questions as to whether the cosmic order of this world is based on action/agent or not? And if an agent is involved and the world and what it contains have to be seen as action, could we declare the cosmic order a providential order? are among the problems which have always occupied the mind of philosophers.      Reading through Platonic corpse leads us to the conclusion that he has founded his metaphysics upon the very idea of world of ideas. According to his works and words, Plato is a proponent of the theory of ideas. As a matter of fact, Plato's metaphysics lies in the theory of ideas. Plato illustrates the general makeup of the world of ideas and the way sensible objects stand in relation with the beings dwelling in the latter world by the well-known cave allegory in the seventh book of Republic. In his view, whatever we find around ourselves not only are not authentic realities but rather they are merely shadows of the truth. Every phenomenon has an essence or reality which is known as its form. The idea of Good overshadows the other ideas insofar as these latter ideas or forms are seen as the effects of the former. It seems we can take God, the One, Absolute Good, Absolute Beauty and Good in itself as expressions of the same reality which Plato has used in different contexts through his works. Along these terms some other notions have also been brought up like intellect, divine intellect, Demiurge, ideas and the particulars of material world. By explaining Plato's taking of these notions and terms, we believe, one can discover Platonic ontological system.    In Republic, Plato argues that God is the creator of ideal bed and all other things, and he is the creator of intelligible entities (ideas. The One or reality as a whole not only contains ideas but the spirit too. The One is the final principle and the source of ideas and is beyond all human attributes. Having said these, it is not clear how reason gets itself related to the

  12. An analysis of female entrepreneurship and innovation in Serbia in the context of EU competitiveness

    Directory of Open Access Journals (Sweden)

    Popović-Pantić Sanja

    2014-01-01

    Full Text Available In economies that are led by innovation, innovativeness and competitiveness are interdependent. If an enterprise and/or economy is competitive in the market it will likely have a high level of innovation management, harmonized with EU standards. A variety of different methodologies is used to assess the innovation capacities of small and medium sized companies, but IMPіrove methodology is widespread in EU countries. It is a benchmarking process which gives, as the final output, a comprehensive report on how to improve and leverage innovation management for profitable growth, which includes a identification of the gaps hampering growth and b the direction in which and how the company should be developed and grown. For the purpose of this paper, IMPіrove methodology was adjusted and simplified to assess the innovation capacity of a single company without benchmarking. The focus of the paper is 22 Serbian companies owned and managed by women, which were included in innovation scanning according to the IMPіrove methodology in 2010. All companies included in the sample employ more than 10 employees. The resulting analysis aims to provide insight into the holistic innovation capacity of the selected companies through four dimensions of the so-called ‘House of Innovation’1. They are: innovation strategy, innovation organization and culture, innovation process (life cycle management, and enabling factors supporting the development of the company’s innovation management. This analysis provides an overview of the innovation management platform necessary to enhance small and medium enterprises’ (SME business performance and competitiveness in the EU market. The analysis also presents the results of research on the gender aspects of the institutions and programmes that support innovativeness and competitiveness in SMEs. [Projekat Ministarstva nauke Republike Srbije, br. III 47005: Research and Development of the Platform for Science

  13. Descriptive analysis of context evaluation instrument for technical oral presentation skills evaluation: A case study in English technical communication course

    Science.gov (United States)

    Mohamed, Abdullah-Adnan; Asmawi, Adelina; Hamid, Mohd Rashid Ab; Mustafa, Zainol bin

    2015-02-01

    This paper reports a pilot study of Context Evaluation using a self-developed questionnaire distributed among engineering undergraduates at a university under study. The study aims to validate the self-developed questionnaires used in the Context evaluation, a component in the CIPP Model. The Context evaluation assesses background information for needs, assets, problems and opportunities relevant to beneficiaries of the study in a defined environment. Through the questionnaire, background information for the assessment of needs, assets and problems related to the engineering undergraduates' perceptions on the teaching and learning of technical oral presentation skills was collected and analysed. The questionnaire was developed using 5-points Likert scale to measure the constructs under study. They were distributed to 100 respondents with 79 returned. The respondents consisted of engineering undergraduates studied at various faculties at one technical university in Malaysia. The descriptive analysis of data for each item which makes up the construct for Context evaluation is found to be high. This implied that engineering undergraduates showed high interest in teaching and learning of technical oral presentation skills, thus their needs are met. Also, they agreed that assets and facilities are conducive to their learning. In conclusion, the context evaluation involving needs and assets factors are both considerably important; their needs are met and the assets and facilities do support their technical oral presentation skills learning experience.

  14. The analysis of APOL1 genetic variation and haplotype diversity provided by 1000 Genomes project.

    Science.gov (United States)

    Peng, Ting; Wang, Li; Li, Guisen

    2017-08-11

    The APOL1 gene variants has been shown to be associated with an increased risk of multiple kinds of diseases, particularly in African Americans, but not in Caucasians and Asians. In this study, we explored the single nucleotide polymorphism (SNP) and haplotype diversity of APOL1 gene in different races provided by 1000 Genomes project. Variants of APOL1 gene in 1000 Genome Project were obtained and SNPs located in the regulatory region or coding region were selected for genetic variation analysis. Total 2504 individuals from 26 populations were classified as four groups that included Africa, Europe, Asia and Admixed populations. Tag SNPs were selected to evaluate the haplotype diversities in the four populations by HaploStats software. APOL1 gene was surrounded by some of the most polymorphic genes in the human genome, variation of APOL1 gene was common, with up to 613 SNP (1000 Genome Project reported) and 99 of them (16.2%) with MAF ≥ 1%. There were 79 SNPs in the URR and 92 SNPs in 3'UTR. Total 12 SNPs in URR and 24 SNPs in 3'UTR were considered as common variants with MAF ≥ 1%. It is worth noting that URR-1 was presents lower frequencies in European populations, while other three haplotypes taken an opposite pattern; 3'UTR presents several high-frequency variation sites in a short segment, and the differences of its haplotypes among different population were significant (P < 0.01), UTR-1 and UTR-5 presented much higher frequency in African population, while UTR-2, UTR-3 and UTR-4 were much lower. APOL1 coding region showed that two SNP of G1 with higher frequency are actually pull down the haplotype H-1 frequency when considering all populations pooled together, and the diversity among the four populations be widen by the G1 two mutation (P 1  = 3.33E-4 vs P 2  = 3.61E-30). The distributions of APOL1 gene variants and haplotypes were significantly different among the different populations, in either regulatory or coding regions. It could provide

  15. Providing Anesthesia Care in Resource-limited Settings: A 6-year Analysis of Anesthesia Services Provided at Médecins Sans Frontières Facilities.

    Science.gov (United States)

    Ariyo, Promise; Trelles, Miguel; Helmand, Rahmatullah; Amir, Yama; Hassani, Ghulam Haidar; Mftavyanka, Julien; Nzeyimana, Zenon; Akemani, Clemence; Ntawukiruwabo, Innocent Bagura; Charles, Adelin; Yana, Yanang; Moussa, Kalla; Kamal, Mustafa; Suma, Mohamed Lamin; Ahmed, Mowlid; Abdullahi, Mohamed; Wong, Evan G; Kushner, Adam; Latif, Asad

    2016-03-01

    Anesthesia is integral to improving surgical care in low-resource settings. Anesthesia providers who work in these areas should be familiar with the particularities associated with providing care in these settings, including the types and outcomes of commonly performed anesthetic procedures. The authors conducted a retrospective analysis of anesthetic procedures performed at Médecins Sans Frontières facilities from July 2008 to June 2014. The authors collected data on patient demographics, procedural characteristics, and patient outcome. The factors associated with perioperative mortality were analyzed. Over the 6-yr period, 75,536 anesthetics were provided to adult patients. The most common anesthesia techniques were spinal anesthesia (45.56%) and general anesthesia without intubation (33.85%). Overall perioperative mortality was 0.25%. Emergent procedures (0.41%; adjusted odds ratio [AOR], 15.86; 95% CI, 2.14 to 115.58), specialized surgeries (2.74%; AOR, 3.82; 95% CI, 1.27 to 11.47), and surgical duration more than 6 h (9.76%; AOR, 4.02; 95% CI, 1.09 to 14.88) were associated with higher odds of mortality than elective surgeries, minor surgeries, and surgical duration less than 1 h, respectively. Compared with general anesthesia with intubation, spinal anesthesia, regional anesthesia, and general anesthesia without intubation were associated with lower perioperative mortality rates of 0.04% (AOR, 0.10; 95% CI, 0.05 to 0.18), 0.06% (AOR, 0.26; 95% CI, 0.08 to 0.92), and 0.14% (AOR, 0.29; 95% CI, 0.18 to 0.45), respectively. A wide range of anesthetics can be carried out safely in resource-limited settings. Providers need to be aware of the potential risks and the outcomes associated with anesthesia administration in these settings.

  16. Patient assessment within the context of healthcare delivery packages: A comparative analysis.

    Science.gov (United States)

    Rossen, Camilla Blach; Buus, Niels; Stenager, Egon; Stenager, Elsebeth

    2016-01-01

    Due to an increased focus on productivity and cost-effectiveness, many countries across the world have implemented a variety of tools for standardizing diagnostics and treatment. In Denmark, healthcare delivery packages are increasingly used for assessment of patients. A package is a tool for creating coordination, continuity and efficient pathways; each step is pre-booked, and the package has a well-defined content within a predefined category of diseases. The aim of this study was to investigate how assessment processes took place within the context of healthcare delivery packages. The study used a constructivist Grounded Theory approach. Ethnographic fieldwork was carried out in three specialized units: a mental health unit and two multiple sclerosis clinics in Southern Denmark, which all used assessment packages. Several types of data were sampled through theoretical sampling. Participant observation was conducted for a total of 126h. Formal and informal interviews were conducted with 12 healthcare professionals and 13 patients. Furthermore, audio recordings were made of 9 final consultations between physicians and patients; 193min of recorded consultations all in all. Lastly, the medical records of 13 patients and written information about packages were collected. The comparative, abductive analysis focused on the process of assessment and the work made by all the actors involved. In this paper, we emphasized the work of healthcare professionals. We constructed five interrelated categories: 1. "Standardized assessing", 2. "Flexibility", which has two sub-categories, 2.1. "Diagnostic options" and 2.2. "Time and organization", and, finally, 3. "Resisting the frames". The process of assessment required all participants to perform the predefined work in the specified way at the specified time. Multidisciplinary teamwork was essential for the success of the process. The local organization of the packages influenced the assessment process, most notably the pre

  17. Experimental and numerical analysis of coastal protection provided by natural ecosystems

    Science.gov (United States)

    Maza, M.; Lara, J. L.; Losada, I. J.; Nepf, H. M.

    2016-12-01

    The risk of flooding and erosion is increasing for many coastal areas owing to global and regional changes in climate conditions together with increasing exposure and vulnerability. After hurricane Katrina (2005) and Sandy (2012) and the tsunami in Indonesia (2004), coastal managers have become interested in low environmental impact alternatives, or nature-based solutions, to protect the coast. Although capacity for coastal ecosystems to damp flow energy has been widely recognized, they have not been firmly considered in the portfolio of coastal protection options. This is mainly due to the complexity of flow-vegetation interaction and of quantifying the value of coastal protection provided by these ecosystems. This complex problem involves different temporal and spatial scales and disciplines, such as engineering, ecology and economics. This work aims to make a step forward in better understanding the physics involved in flow-vegetation interaction leading to new formulations and parameterizations to address some unsolved questions in literature: the representation of plants and field properties; the influence of wave parameters on the relevant processes; the role of the combined effect of waves and currents and the effect of extreme events on vegetation elements. The three main coastal vegetated ecosystems (seagrasses, saltmarshes and mangroves) are studied with an experimental and numerical approach. Experimental analysis is carried out using mimics and real vegetation, considering different flow and vegetation parameters and characterizing flow energy attenuation for the different scenarios. Numerical simulations are performed using 2-D and 3-D Navier-Stokes models in which the effect of vegetation is implemented and validated. These models are used to extend experimental results by simulating different vegetation distributions and analyzing variables such as high-spatial-resolution free surface and velocity data and forces exerted on vegetation elements.

  18. Pathway analysis of GWAS provides new insights into genetic susceptibility to 3 inflammatory diseases.

    Directory of Open Access Journals (Sweden)

    Hariklia Eleftherohorinou

    2009-11-01

    Full Text Available Although the introduction of genome-wide association studies (GWAS have greatly increased the number of genes associated with common diseases, only a small proportion of the predicted genetic contribution has so far been elucidated. Studying the cumulative variation of polymorphisms in multiple genes acting in functional pathways may provide a complementary approach to the more common single SNP association approach in understanding genetic determinants of common disease. We developed a novel pathway-based method to assess the combined contribution of multiple genetic variants acting within canonical biological pathways and applied it to data from 14,000 UK individuals with 7 common diseases. We tested inflammatory pathways for association with Crohn's disease (CD, rheumatoid arthritis (RA and type 1 diabetes (T1D with 4 non-inflammatory diseases as controls. Using a variable selection algorithm, we identified variants responsible for the pathway association and evaluated their use for disease prediction using a 10 fold cross-validation framework in order to calculate out-of-sample area under the Receiver Operating Curve (AUC. The generalisability of these predictive models was tested on an independent birth cohort from Northern Finland. Multiple canonical inflammatory pathways showed highly significant associations (p 10(-3-10(-20 with CD, T1D and RA. Variable selection identified on average a set of 205 SNPs (149 genes for T1D, 350 SNPs (189 genes for RA and 493 SNPs (277 genes for CD. The pattern of polymorphisms at these SNPS were found to be highly predictive of T1D (91% AUC and RA (85% AUC, and weakly predictive of CD (60% AUC. The predictive ability of the T1D model (without any parameter refitting had good predictive ability (79% AUC in the Finnish cohort. Our analysis suggests that genetic contribution to common inflammatory diseases operates through multiple genes interacting in functional pathways.

  19. Comparative transcriptomic analysis provides insights into antibacterial mechanisms of Branchiostoma belcheri under Vibrio parahaemolyticus infection.

    Science.gov (United States)

    Zhang, Qi-Lin; Zhu, Qian-Hua; Liang, Ming-Zhong; Wang, Feng; Guo, Jun; Deng, Xian-Yu; Chen, Jun-Yuan; Wang, Yu-Jun; Lin, Lian-Bing

    2018-05-01

    Amphioxus, a basal chordate, is widely considered to be an existing proxy of the invertebrate ancestor of vertebrates, and it exhibits susceptibility to various pathogen infections and pathogenic mimic challenges. Here, in order to understand more clearly its antibacterial mechanisms, we analyzed the ribosomal RNA (rRNA)-depleted transcriptome of Chinese amphioxus (Branchiostoma belcheri) infected with Vibrio parahaemolyticus (V. p.) via next-generation deep sequencing technology (RNA-seq). We identified a total of 3214 differentially expressed genes (DEGs) by comparing V. p.-infected and control transcriptome libraries, including 2219 significantly up-regulated and 995 significantly down-regulated DEGs in V. p.-infected amphioxus. The DEGs with the top 10 most dramatic expression fold changes after V. p. infection, as well as 53 immune-related DEGs (IRDs) belonging to four primary categories of innate immunity were analyzed further. Through gene ontology (GO) and pathway enrichment analysis, DEGs were found to be primarily related to immune processes, apoptosis, catabolic and metabolic processes, binding and enzyme activity, while pathways involving bacterial infection, immune signaling, immune response, cancer, and apoptosis were overrepresented. We validated the RNA-seq results by detecting the expression levels of 10 IRDs using qRT-PCR, and we surveyed the dynamic variation in gene expression for these IRDs at 0, 6, 12, 24, and 48 h after V. p. Subsequently, according to the RNA-seq results, the presence of a primitive Toll-like receptor (TLR)-mediated antibacterial immune signaling pathway was predicted in B. belcheri. This study provides valuable information regarding antibacterial immunity for further research into the evolution of immunity in vertebrates and broadens our understanding of the innate immune response against bacterial invasion in amphioxus. Copyright © 2018 Elsevier Ltd. All rights reserved.

  20. Robust moving ship detection using context-based motion analysis and occlusion handling

    NARCIS (Netherlands)

    Bao, X.; Zinger, S.; Wijnhoven, R.G.J.; With, de P.H.N.

    2013-01-01

    This paper proposes an original moving ship detection approach in video surveillance systems, especially con- centrating on occlusion problems among ships and vegetation using context information. Firstly, an over- segmentation is performed to divide and classify by SVM (Support Vector Machine)

  1. Student Motivation in Low-Stakes Assessment Contexts: An Exploratory Analysis in Engineering Mechanics

    Science.gov (United States)

    Musekamp, Frank; Pearce, Jacob

    2016-01-01

    The goal of this paper is to examine the relationship of student motivation and achievement in low-stakes assessment contexts. Using Pearson product-moment correlations and hierarchical linear regression modelling to analyse data on 794 tertiary students who undertook a low-stakes engineering mechanics assessment (along with the questionnaire of…

  2. Medical Professionals and Parents: A Linguistic Analysis of Communication Across Contexts.

    Science.gov (United States)

    Tannen, Deborah; Wallat, Cynthia

    1986-01-01

    This study analyzes videotaped conversations between various family members of a child with cerebral palsy and medical professionals. The conversations are examined for information elaboration and condensation, information negotiation, as well as methodological benefits. The medical interviews elicited new information in various contexts and…

  3. Fathers in Context: Comparative Analysis of Father Involvement in Bulgaria and the Netherlands

    NARCIS (Netherlands)

    N.A. Conkova (Nina); B.E. Ory (Brett)

    2016-01-01

    markdownabstractThis report compares father involvement with their children in Bulgaria and the Netherlands by examining country differences in family formation patterns, policy context, and cultural prescriptions regarding family life. In studying the time fathers spend with their children, it is

  4. Analysis and modification of traditional games and sports towards their correct use in educational contexts

    Directory of Open Access Journals (Sweden)

    Antonio Méndez-Giménez

    2011-01-01

    Full Text Available This article supports the idea of modifying traditional games and sports in order to provide students with significant educational experiences. First, a structural-functional analysis of traditional games is presented. Second, a teaching strategy to enhance their potential in physical education classes is introduced. Third, an approach to make traditional games more vivid for students is offered. The structure of each of the traditional games’ categories is revised, and a few changes are introduced bearing in mind the children’s characteristics and the school context’s limitations. Finally, homemade materials are presented as a perfect tool for these changes, and to foster children’s participation and motivation on traditional games

  5. Stability of Tl(III) in the context of speciation analysis of thallium in plants.

    Science.gov (United States)

    Sadowska, Monika; Biaduń, Ewa; Krasnodębska-Ostręga, Beata

    2016-02-01

    The paper presents both "good" and "bad" results obtained during speciation analysis of thallium in plant tissues of a hyperaccumulator of this metal. The object was white mustard - Sinapis alba L. In this plant there were found traces of trivalent thallium. The crucial point of this study (especially in the case of so unstable thallium form as Tl(III)) was to prove that the presence of Tl(III) was not caused by the procedure of sample preparation itself, and that the whole analytical method provides reliable results. Choice of the method for conservation of the initial speciation, extraction with the highest efficiency and proving the correctness of the obtained data were the most difficult parts of the presented study. It was found that: both freezing and drying cause significant changes in the speciation of thallium; quantitative analysis could be performed only with fresh tissues of mustard plants; only short-term storage of an extract from fresh plant tissues is possible; the methodology is not the source of thallium (III); only the presence of DTPA can greatly limit the reduction of TI(III) to TI(I) (up to 1-3%); the UV irradiation results in disintegration of TI(III)DTPA in the presence of plant matrix (reduction up to 90%). Copyright © 2015 Elsevier Ltd. All rights reserved.

  6. An overview of the evolution of human reliability analysis in the context of probabilistic risk assessment

    International Nuclear Information System (INIS)

    Bley, Dennis C.; Lois, Erasmia; Kolaczkowski, Alan M.; Forester, John Alan; Wreathall, John; Cooper, Susan E.

    2009-01-01

    Since the Reactor Safety Study in the early 1970's, human reliability analysis (HRA) has been evolving towards a better ability to account for the factors and conditions that can lead humans to take unsafe actions and thereby provide better estimates of the likelihood of human error for probabilistic risk assessments (PRAs). The purpose of this paper is to provide an overview of recent reviews of operational events and advances in the behavioral sciences that have impacted the evolution of HRA methods and contributed to improvements. The paper discusses the importance of human errors in complex human-technical systems, examines why humans contribute to accidents and unsafe conditions, and discusses how lessons learned over the years have changed the perspective and approach for modeling human behavior in PRAs of complicated domains such as nuclear power plants. It is argued that it has become increasingly more important to understand and model the more cognitive aspects of human performance and to address the broader range of factors that have been shown to influence human performance in complex domains. The paper concludes by addressing the current ability of HRA to adequately predict human failure events and their likelihood

  7. An overview of the evolution of human reliability analysis in the context of probabilistic risk assessment.

    Energy Technology Data Exchange (ETDEWEB)

    Bley, Dennis C. (Buttonwood Consulting Inc., Oakton, VA); Lois, Erasmia (U.S. Nuclear Regulatory Commission, Washington, DC); Kolaczkowski, Alan M. (Science Applications International Corporation, Eugene, OR); Forester, John Alan; Wreathall, John (John Wreathall and Co., Dublin, OH); Cooper, Susan E. (U.S. Nuclear Regulatory Commission, Washington, DC)

    2009-01-01

    Since the Reactor Safety Study in the early 1970's, human reliability analysis (HRA) has been evolving towards a better ability to account for the factors and conditions that can lead humans to take unsafe actions and thereby provide better estimates of the likelihood of human error for probabilistic risk assessments (PRAs). The purpose of this paper is to provide an overview of recent reviews of operational events and advances in the behavioral sciences that have impacted the evolution of HRA methods and contributed to improvements. The paper discusses the importance of human errors in complex human-technical systems, examines why humans contribute to accidents and unsafe conditions, and discusses how lessons learned over the years have changed the perspective and approach for modeling human behavior in PRAs of complicated domains such as nuclear power plants. It is argued that it has become increasingly more important to understand and model the more cognitive aspects of human performance and to address the broader range of factors that have been shown to influence human performance in complex domains. The paper concludes by addressing the current ability of HRA to adequately predict human failure events and their likelihood.

  8. How do health behaviour interventions take account of social context? A literature trend and co-citation analysis.

    Science.gov (United States)

    Holman, Daniel; Lynch, Rebecca; Reeves, Aaron

    2017-03-01

    In recent years, health behaviour interventions have received a great deal of attention in both research and policy as a means of encouraging people to lead healthier lives. The emphasis of such interventions has varied over time, in terms of level of intervention (e.g. individual vs community) and drawing on different disciplinary perspectives. Recently, a number of critiques have focused on how health behaviour interventions sometimes sideline issues of social context, framing health as a matter of individual choice and, by implication, a personal responsibility. Part of this criticism is that health behaviour interventions often do not draw on alternative social science understandings of the structured and contextual aspects of behaviour and health. Yet to our knowledge, no study has attempted to empirically assess the extent to which, and in what ways, the health behaviour intervention field has paid attention to social context. In this article, we undertake this task using bibliometric techniques in order to map out the health behaviour intervention field. We find that the number of health behaviour interventions has grown rapidly in recent years, especially since around 2006, and that references to social science disciplines and concepts that foreground issues of social context are rare and, relatively speaking, constitute less of the field post 2006. More quantifiable concepts are used most, and those more close to the complexities of social context are mentioned least. The document co-citation analysis suggests that pre 2006, documents referring to social context were relatively diffuse in the network of key citations, but post 2006 this influence had largely diminished. The journal co-citation analysis shows less disciplinary overlap post 2006. At present, health behaviour interventions are continuing to focus on individualised approaches drawn from behavioural psychology and behavioural economics. Our findings lend empirical support to a number of recent

  9. Provenance studies of obsidians from Neolithic contexts in Southern Italy by IBA (Ion Beam Analysis) methods

    International Nuclear Information System (INIS)

    Quarta, Gianluca; Maruccio, Lucio; Calcagnile, Lucio

    2011-01-01

    Obsidian samples recovered in archaeological contexts in Southern Italy were analysed by PIXE (Particle Induced X-ray Emission) and PIGE (Particle Induced Gamma Ray Emission) for the quantitative determination of both major and trace elements composition. The archaeological contexts were absolutely dated to the 5th millennium BC by mean of AMS (Accelerator Mass Spectrometry) radiocarbon dating analyses carried out on associated organic materials such as charcoal and human bones. The comparison of the compositional results obtained for the analysed samples with published data available for the known obsidian sources in the Mediterranean allowed to identify the sources of the raw material, giving an important contribution to the reconstruction of the ancient trade and exchange routes in Southern Italy prehistory.

  10. Comparison of Gratitude across Context Variations: A Generic Analysis of Dissertation Acknowledgements Written by Taiwanese Authors in EFL and ESL Contexts

    Directory of Open Access Journals (Sweden)

    Wenhsien Yang

    2012-09-01

    Full Text Available Research on generic structures of acknowledgements in dissertations has gradually drawn attention in various contexts. However, there is relatively scant research on the ways in which acknowledgements are written by authors with mutually similar cultural backgrounds but in two different academic environments and language contexts. To fill this gap, this study compared 60 PhD dissertation acknowledgements written by Taiwanese postgraduates in Taiwan, an EFL context, with another 60 written by Taiwanese scholars who obtained their doctorates in the United States, an ESL context. The focus was on the generic structures and linguistic features of the writing styles of the two groups. The study aimed to investigate whether divergences existed in the two different academic and language settings, but with the writers sharing the same cultural and language background. If such divergences did exist, the likely causes would be explored. The results revealed that firstly, the participants in both contexts generally followed a three-tier structure when writing their dissertation acknowledgements, namely, reflecting, thanking, and announcing moves. However, academic conventions, institutional preferences and the language context, together with socio-cultural factors, affected their construction of moves/steps and their choice of linguistic elements. It was found that the rhetorical language in both corpora was relatively direct, emotional and precise.

  11. Psychometric analysis of export market orientation measurement scale in Croatian SME exporters’ context

    OpenAIRE

    Miočević, Dario; Crnjak-Karanović, Biljana

    2009-01-01

    Market orientation is a vital construct of the marketing concept. Although different conceptualization approaches to market orientation have been discussed by literature so far, a common denominator is its interdependence with business performance. Increasing globalization trends affect both the markets’ convergence and competition. Consequently, focusing on market orientation within an international context is of utmost importance. Export market orientation (EMO) is relatively new concept, w...

  12. Cost Benefit Analysis of Providing Level II Trauma Care at William Beaumont Army Medical Center (WBAMC)

    National Research Council Canada - National Science Library

    Gerepka, Peter

    2002-01-01

    .... During the period from 1 October 2000 to 30 September 2001, WBAMC, a designated Level II trauma center by the American College of Surgeons, provided care for 410 patients of which 181 were civilian emergencies...

  13. Is frozen embryo transfer better for mothers and babies? Can cumulative meta-analysis provide a definitive answer?

    Science.gov (United States)

    Maheshwari, Abha; Pandey, Shilpi; Amalraj Raja, Edwin; Shetty, Ashalatha; Hamilton, Mark; Bhattacharya, Siladitya

    2018-01-01

    and magnitude of effect for these outcomes have remained virtually unchanged over time while the degree of precision has improved with the addition of data from newer studies. The results of this cumulative meta-analysis confirm that the decreased risks of small for gestational age, low birth weight and preterm delivery and increased risks of large for gestational age and high birth weight associated with pregnancies conceived from frozen embryos have been consistent in terms of direction and magnitude of effect over several years, with increasing precision around the point estimates. Replication in a number of different populations has provided external validity for the results, for outcomes of birth weight and preterm delivery. Meanwhile, caution should be exercised about embarking on a policy of electively freezing all embryos in IVF as there are increased risks for large for gestational age babies and hypertensive disorders of pregnancy. Therefore, elective freezing should ideally be undertaken in specific cases such as ovarian hyperstimulation syndrome, fertility preservation or in the context of randomised trials. © The Author 2017. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oup.com

  14. The mother who cannot provide liberation: family atom analysis of women victims of domestic violence

    Directory of Open Access Journals (Sweden)

    Maria Silvia Guglielmin

    2014-06-01

    Full Text Available The present contribution presents the discussion about the analysis carried out on family atoms that were completed in the first psychodrama group meetings carried out in all the Empower Daphne III program partner countries. The issue of the relationship with the mother is central to the aim of the project, in that we hypothesise that the mothers of victims are incapable of educating their daughters about personal autonomy in relation to men, due to the traditional culture in which they grew up in. The article presents information about the use and processing of the survey tool “Family atom ” created by Jacob Moreno and the analysis of the data that emerged in parallel to the reports sent periodically by the psychodramatists to the monitoring and analysis team. From the results three types of maternal relationships emerge (positive, negative and incongruent that enable us to confirm the initial hypothesis of this action research.

  15. AN ANALYSIS OF THE ROMANIAN FISHERY SECTOR IN THE EUROPEAN COMMUNITY CONTEXT

    Directory of Open Access Journals (Sweden)

    Silvius STANCIU

    2015-12-01

    Full Text Available The development of the fishery sector represents one of the European Union’s priorities due to the positive impact it has on food security and to its potential to ensure nutritious and quality food at an affordable price as compared to other animal-origin resources. The Community policy in the fishery sector focuses on reducing the Community market dependence on imports and on the sustainable development of business in this domain. Romania aligned with the Community policies and, therefore, important funds were allocated to the national fishery sector. The diversified natural resources, the possibility to use friendly technologies, the qualified staff, the tradition in the domain, and the existence of a number of niche markets all represent motivations for the development of the Romanian fishery sector. The present paper proposes an analysis of the Romanian fishery production and of the European financing effects on the specialized companies. Despite the fact that there have been important resources allocated to the sector and there is a slight positive evolution, the absorption of funds was difficult. The results of the investment may be observed after a long period of time, this is why Romania is still dependent on fishery product imports. Aquaculture represents the main segment towards which the European funds were directed, including in our country, thus providing the greatest part of the income and employment in the domain.

  16. A DIMENSIONAL ANALYSIS OF DESTINATION IMAGE VARIABLESIN A SOUTH AFRICAN CONTEXT: AN EXPLORATORY STUDY

    Directory of Open Access Journals (Sweden)

    BA Mokoena

    2016-07-01

    Full Text Available It is generally accepted in tourismliterature that destination image (DI, theimportance of which is universally acknowledged, is often used as a significantelement for local tourists in the choice of a vacation destination. The purpose ofthis study was to identify the dimensions that influence tourists’ perceptions of adestination. A comprehensive literature study of DI was undertaken. In addition, aquestionnaire was developed to elicit information from a purposively selectedsample of 350 participants who had visited the city of Durban in the KwaZulu-Natal province of South Africa during the past eightmonths prior to the datacollection. Cronbach’s alpha coefficient was used to measure the reliability of themeasurement scale. Descriptive statistics wereused to describe the sample profile.Exploratory factor analysis was conducted to identify the dimensions influencingDI. Through this process seven dimensions, namely destination appreciation,weather and climate, tourism information, travel environment, shopping,community attitudeand spatial layout were identified. Based on the findings,recommendations are made to develop strategies to improve and maintain theimage of Durban so that tourists are attracted to the city. Implications for furtherresearch are also provided.

  17. The ethical task of secondary teachers: An analysis through their attitudes and reasoning. Case study in the Mexican context

    Directory of Open Access Journals (Sweden)

    Marcela HERNÁNDEZ GONZÁLEZ

    2016-06-01

    Full Text Available This study focused on the analysis of professional ethics of teachers. It is considered important because this teaching is itself an ethical activity because it touches on the whole person of the learner to encourage it to be gradually a better subject.Moral reasoning and moral attitudes: to have a professional approach to this ethic two related elements were studied. A case study located in Mexico, in the Superior Normal School of Michoacán (ensm, initial training institution was performed, but also welcomes teachers in service for further studies and graduate. Methods of quantitative and qualitative research in the same investigation were integrated approach known as hybrid or mixed method. The instruments were built Likert scale, hypothetical and real moral dilemmas. And the implementation of group discussion with experts.The work investigated on major ethical problems of secondary teachers, argumentation processes performed to make ethical decisions and principal values present.The results found that ethical aspects have an important place in their educational conception. Also there is a high emotional charge in moral attitudes, which are transformed along the experience and professional cycling stage that is going through.Moreover, the presence of the principles of justice and charity in ethical conflicts was recognized, and the importance of the ability of moral sensibility as an element that favors the appropriate educational practices and ethical development of students and educators.The study provides knowledge of reflection to be implemented in teacher training, seeking to promote professional ethics in secondary teachers respond to the needs and demands of the current context.

  18. Generative Contexts

    Science.gov (United States)

    Lyles, Dan Allen

    Educational research has identified how science, technology, engineering, and mathematics (STEM) practice and education have underperforming metrics in racial and gender diversity, despite decades of intervention. These disparities are part of the construction of a culture of science that is alienating to these populations. Recent studies in a social science framework described as "Generative Justice" have suggested that the context of social and scientific practice might be modified to bring about more just and equitable relations among the disenfranchised by circulating the value they and their non-human allies create back to them in unalienated forms. What is not known are the underlying principles of social and material space that makes a system more or less generative. I employ an autoethnographic method at four sites: a high school science class; a farm committed to "Black and Brown liberation"; a summer program geared towards youth environmental mapping; and a summer workshop for Harlem middle school students. My findings suggest that by identifying instances where material affinity, participatory voice, and creative solidarity are mutually reinforcing, it is possible to create educational contexts that generate unalienated value, and circulate it back to the producers themselves. This cycle of generation may help explain how to create systems of justice that strengthen and grow themselves through successive iterations. The problem of lack of diversity in STEM may be addressed not merely by recruiting the best and the brightest from underrepresented populations, but by changing the context of STEM education to provide tools for its own systematic restructuring.

  19. An Analysis of Personal Technology Use by Service Members and Military Behavioral Health Providers.

    Science.gov (United States)

    Edwards-Stewart, Amanda; Smolenski, Derek J; Reger, Greg M; Bush, Nigel; Workman, Don E

    2016-07-01

    Personal technology use is ubiquitous in the United States today and technology, in general, continues to change the face of health care. However, little is known about the personal technology use of military service members and the behavioral health care providers that treat them. This study reports the technology use of 1,101 active duty service members and 45 behavioral health care providers at a large military installation. Participants reported Internet usage; ownership of smartphones, tablets, and e-readers; usage of mobile applications (apps); and basic demographic information. Compared with providers, service members reported higher rates of smartphone ownership, were more likely to own Android smartphones than iPhones, and spent more time gaming. Both groups spent a comparable amount of time using social media. With the exception of gaming, however, differences between service members and providers were not statistically significant when demographics were matched and controlled. Among service members, younger respondents (18-34) were statistically more likely than older respondents (35-58) to own smartphones, spend time gaming, and engage in social media. Our findings can help inform provider's technology-based education and intervention of their patients and guide the development of new technologies to support the psychological health of service members. Reprint & Copyright © 2016 Association of Military Surgeons of the U.S.

  20. FACTOR ANALYSIS ABOUT EXCLUSIVE BREASTFEEDING ACHIEVEMENT LEVEL AMONG MOTHERS WHO PROVIDE BREASTMILK TO THEIR CHILDREN

    Directory of Open Access Journals (Sweden)

    Tiyas Kusumaningrum

    2017-04-01

    Full Text Available Introduction: The number of mother who breastfeed their babies exclusively in Indonesia is low. It caused by many factors such as high intensity of formula milk advertisement, lack of awareness about the importance of breastfeeding, working mother, social culture, family support and the role of health care provider. The purpose of this research was to analyze factors related with successfulness level of exclusive breastfeeding. Method: Design used in this research was analytic retrospective. The population were all mothers at Pacarkeling Public Health Center area. Sample obtained through purposive sampling. Total sample was 61 respondents. Independent variables were knowledge, information and promotion, family support, social cultural, role of health provider, work/occupation, education and breast physiology anatomy. The dependent variable was exclusive breastfeeding. Result: The result indicated that exclusive breastfeeding achievement level was related with information and promotion (r = 0.271, family support (r = 373, health care provider role (r = 231, mother occupation (r = 251, anatomy and physiology of breast (r = 293, while the knowledge (r = 108, social cultural (r = 180 and education (r = 093 not significantly related. Discussion: In conclusion, there was a positive correlation between information and promotion, family support, health care provider role, mother’s occupation, anatomy and physiology of breast with successfulness level of exclusive breastfeeding. While the knowledge, social cultural and education did not indicate significant result. Therefore it is suggested to increase the quantity and quality of information and promotion about exclusive breastfeeding to the society, health care provider and pregnant and breastfeeding mother.

  1. A multifactorial analysis of obesity as CVD risk factor: Use of neural network based methods in a nutrigenetics context

    Directory of Open Access Journals (Sweden)

    Valavanis Ioannis K

    2010-09-01

    Full Text Available Abstract Background Obesity is a multifactorial trait, which comprises an independent risk factor for cardiovascular disease (CVD. The aim of the current work is to study the complex etiology beneath obesity and identify genetic variations and/or factors related to nutrition that contribute to its variability. To this end, a set of more than 2300 white subjects who participated in a nutrigenetics study was used. For each subject a total of 63 factors describing genetic variants related to CVD (24 in total, gender, and nutrition (38 in total, e.g. average daily intake in calories and cholesterol, were measured. Each subject was categorized according to body mass index (BMI as normal (BMI ≤ 25 or overweight (BMI > 25. Two artificial neural network (ANN based methods were designed and used towards the analysis of the available data. These corresponded to i a multi-layer feed-forward ANN combined with a parameter decreasing method (PDM-ANN, and ii a multi-layer feed-forward ANN trained by a hybrid method (GA-ANN which combines genetic algorithms and the popular back-propagation training algorithm. Results PDM-ANN and GA-ANN were comparatively assessed in terms of their ability to identify the most important factors among the initial 63 variables describing genetic variations, nutrition and gender, able to classify a subject into one of the BMI related classes: normal and overweight. The methods were designed and evaluated using appropriate training and testing sets provided by 3-fold Cross Validation (3-CV resampling. Classification accuracy, sensitivity, specificity and area under receiver operating characteristics curve were utilized to evaluate the resulted predictive ANN models. The most parsimonious set of factors was obtained by the GA-ANN method and included gender, six genetic variations and 18 nutrition-related variables. The corresponding predictive model was characterized by a mean accuracy equal of 61.46% in the 3-CV testing sets

  2. A multifactorial analysis of obesity as CVD risk factor: use of neural network based methods in a nutrigenetics context.

    Science.gov (United States)

    Valavanis, Ioannis K; Mougiakakou, Stavroula G; Grimaldi, Keith A; Nikita, Konstantina S

    2010-09-08

    Obesity is a multifactorial trait, which comprises an independent risk factor for cardiovascular disease (CVD). The aim of the current work is to study the complex etiology beneath obesity and identify genetic variations and/or factors related to nutrition that contribute to its variability. To this end, a set of more than 2300 white subjects who participated in a nutrigenetics study was used. For each subject a total of 63 factors describing genetic variants related to CVD (24 in total), gender, and nutrition (38 in total), e.g. average daily intake in calories and cholesterol, were measured. Each subject was categorized according to body mass index (BMI) as normal (BMI ≤ 25) or overweight (BMI > 25). Two artificial neural network (ANN) based methods were designed and used towards the analysis of the available data. These corresponded to i) a multi-layer feed-forward ANN combined with a parameter decreasing method (PDM-ANN), and ii) a multi-layer feed-forward ANN trained by a hybrid method (GA-ANN) which combines genetic algorithms and the popular back-propagation training algorithm. PDM-ANN and GA-ANN were comparatively assessed in terms of their ability to identify the most important factors among the initial 63 variables describing genetic variations, nutrition and gender, able to classify a subject into one of the BMI related classes: normal and overweight. The methods were designed and evaluated using appropriate training and testing sets provided by 3-fold Cross Validation (3-CV) resampling. Classification accuracy, sensitivity, specificity and area under receiver operating characteristics curve were utilized to evaluate the resulted predictive ANN models. The most parsimonious set of factors was obtained by the GA-ANN method and included gender, six genetic variations and 18 nutrition-related variables. The corresponding predictive model was characterized by a mean accuracy equal of 61.46% in the 3-CV testing sets. The ANN based methods revealed factors

  3. Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution.

    Science.gov (United States)

    2004-12-09

    We present here a draft genome sequence of the red jungle fowl, Gallus gallus. Because the chicken is a modern descendant of the dinosaurs and the first non-mammalian amniote to have its genome sequenced, the draft sequence of its genome--composed of approximately one billion base pairs of sequence and an estimated 20,000-23,000 genes--provides a new perspective on vertebrate genome evolution, while also improving the annotation of mammalian genomes. For example, the evolutionary distance between chicken and human provides high specificity in detecting functional elements, both non-coding and coding. Notably, many conserved non-coding sequences are far from genes and cannot be assigned to defined functional classes. In coding regions the evolutionary dynamics of protein domains and orthologous groups illustrate processes that distinguish the lineages leading to birds and mammals. The distinctive properties of avian microchromosomes, together with the inferred patterns of conserved synteny, provide additional insights into vertebrate chromosome architecture.

  4. Gender Differences in Public and Private Drinking Contexts: A Multi-Level GENACIS Analysis

    Directory of Open Access Journals (Sweden)

    Jason C. Bond

    2010-05-01

    Full Text Available This multi-national study hypothesized that higher levels of country-level gender equality would predict smaller differences in the frequency of women’s compared to men’s drinking in public (like bars and restaurants settings and possibly private (home or party settings. GENACIS project survey data with drinking contexts included 22 countries in Europe (8; the Americas (7; Asia (3; Australasia (2, and Africa (2, analyzed using hierarchical linear models (individuals nested within country. Age, gender and marital status were individual predictors; country-level gender equality as well as equality in economic participation, education, and political participation, and reproductive autonomy and context of violence against women measures were country-level variables. In separate models, more reproductive autonomy, economic participation, and educational attainment and less violence against women predicted smaller differences in drinking in public settings. Once controlling for country-level economic status, only equality in economic participation predicted the size of the gender difference. Most country-level variables did not explain the gender difference in frequency of drinking in private settings. Where gender equality predicted this difference, the direction of the findings was opposite from the direction in public settings, with more equality predicting a larger gender difference, although this relationship was no longer significant after controlling for country-level economic status. Findings suggest that country-level gender equality may influence gender differences in drinking. However, the effects of gender equality on drinking may depend on the specific alcohol measure, in this case drinking context, as well as on the aspect of gender equality considered. Similar studies that use only global measures of gender equality may miss key relationships. We consider potential implications for alcohol related consequences, policy and public

  5. Gender differences in public and private drinking contexts: a multi-level GENACIS analysis.

    Science.gov (United States)

    Bond, Jason C; Roberts, Sarah C M; Greenfield, Thomas K; Korcha, Rachael; Ye, Yu; Nayak, Madhabika B

    2010-05-01

    This multi-national study hypothesized that higher levels of country-level gender equality would predict smaller differences in the frequency of women's compared to men's drinking in public (like bars and restaurants) settings and possibly private (home or party) settings. GENACIS project survey data with drinking contexts included 22 countries in Europe (8); the Americas (7); Asia (3); Australasia (2), and Africa (2), analyzed using hierarchical linear models (individuals nested within country). Age, gender and marital status were individual predictors; country-level gender equality as well as equality in economic participation, education, and political participation, and reproductive autonomy and context of violence against women measures were country-level variables. In separate models, more reproductive autonomy, economic participation, and educational attainment and less violence against women predicted smaller differences in drinking in public settings. Once controlling for country-level economic status, only equality in economic participation predicted the size of the gender difference. Most country-level variables did not explain the gender difference in frequency of drinking in private settings. Where gender equality predicted this difference, the direction of the findings was opposite from the direction in public settings, with more equality predicting a larger gender difference, although this relationship was no longer significant after controlling for country-level economic status. Findings suggest that country-level gender equality may influence gender differences in drinking. However, the effects of gender equality on drinking may depend on the specific alcohol measure, in this case drinking context, as well as on the aspect of gender equality considered. Similar studies that use only global measures of gender equality may miss key relationships. We consider potential implications for alcohol related consequences, policy and public health.

  6. Thermal balneotherapy in Antsirabe-Madagascar: water analysis and its applications in an African context.

    Science.gov (United States)

    Pedrazzini, Alessio; Delsignore, Roberto; Martelli, Alessandra; Tocco, Silvio; Vaienti, Enrico; Ceccarelli, Francesco; Pogliacomi, Francesco

    2016-04-15

    The Orthopaedic Rehabilitation Centre of Madagascar can be found in the city of Antsirabe. The health care facility is equipped with 2 thermal sources of bicarbonate water used for post-operative rehabilitation and for the ailment of chronic degenerative illnesses. The aim of this study, which derives from the cooperation between the School of Specialization in Thermal Therapy of the University of Parma and Antsirabe Orthopaedic Hospital, is to analyze the real properties of thermal waters utilized in this centre and to do an overview of its possible applications in this particular African context.

  7. Concept Representation Analysis in the Context of Human-Machine Interactions

    DEFF Research Database (Denmark)

    Badie, Farshad

    2016-01-01

    an inductive machine learning paradigm). The results will support figuring out the most significant key points for constructing a conceptual linkage between a human learning theory and a machine learning paradigm. Accordingly, I will construct a conceptual ground for expressing and analysing concepts......This article attempts to make a conceptual and epistemological junction between human learning and machine learning. I will be concerned with specifying and analysing the structure of concepts in the common ground between a concept-based human learning theory and a concept-based machine learning...... in the common ground of human and informatics sciences and in the context of human-machine interplays....

  8. Climate analysis at local scale in the context of climate change

    International Nuclear Information System (INIS)

    Quenol, H.

    2013-01-01

    Issues related to climate change increasingly concern the functioning of local scale geo-systems. A global change will necessarily affect local climates. In this context, the potential impacts of climate change lead to numerous inter rogations concerning adaptation. Despite numerous studies on the impact of projected global warming on different regions global atmospheric models (GCM) are not adapted to local scales and, as a result, impacts at local scales are still approximate. Although real progress in meso-scale atmospheric modeling was realized over the past years, no operative model is in use yet to simulate climate at local scales (ten or so meters). (author)

  9. Quality of Services and Quality of Life from Service Providers' Perspectives: Analysis with Focus Groups

    Science.gov (United States)

    Jenaro, C.; Vega, V.; Flores, N.; Cruz, M.

    2013-01-01

    Background: Concepts such as support, quality of life and quality of services are customary in services for people with intellectual disabilities. The identification of the different ways of conceiving, prioritising and implementing these concepts by service providers can help to drive changes to achieve better personal outcomes for this…

  10. Analysis Of Provided Service Quality In Flowers And Living Plants Transport

    Science.gov (United States)

    Poliaková, Adela

    2015-06-01

    This paper analyses quality of the living flowers and plants transportation. A part of this paper compares the demands for a particular transport mode and a practical demonstration of these transport modes within a specific transport mode. The paper presents a survey of quality of services provided by individual transport modes.

  11. Fact or fiction? An empirical analysis of cooperation between mass sport providers at the local level

    NARCIS (Netherlands)

    Steven Vos; Jeroen Scheerder

    2014-01-01

    This paper explores inter-organisational relationships, in terms of cooperation, between three main types of sport providers at the local level: voluntary sport clubs, for-profit fitness and health clubs, and local sports authorities. Both withinand cross-sector cooperation are analysed and related

  12. Escalation research: Providing new frontiers for applying behavior analysis to organizational behavior

    Science.gov (United States)

    Goltz, Sonia M.

    2000-01-01

    Decision fiascoes such as escalation of commitment, the tendency of decision makers to “throw good money after bad,” can have serious consequences for organizations and are therefore of great interest in applied research. This paper discusses the use of behavior analysis in organizational behavior research on escalation. Among the most significant aspects of behavior-analytic research on escalation is that it has indicated that both the patterns of outcomes that decision makers have experienced for past decisions and the patterns of responses that they make are critical for understanding escalation. This research has also stimulated the refinement of methods by researchers to better assess decision making and the role reinforcement plays in it. Finally, behavior-analytic escalation research has not only indicated the utility of reinforcement principles for predicting more complex human behavior but has also suggested some additional areas for future exploration of decision making using behavior analysis. PMID:22478347

  13. EXP-PAC: providing comparative analysis and storage of next generation gene expression data.

    Science.gov (United States)

    Church, Philip C; Goscinski, Andrzej; Lefèvre, Christophe

    2012-07-01

    Microarrays and more recently RNA sequencing has led to an increase in available gene expression data. How to manage and store this data is becoming a key issue. In response we have developed EXP-PAC, a web based software package for storage, management and analysis of gene expression and sequence data. Unique to this package is SQL based querying of gene expression data sets, distributed normalization of raw gene expression data and analysis of gene expression data across experiments and species. This package has been populated with lactation data in the international milk genomic consortium web portal (http://milkgenomics.org/). Source code is also available which can be hosted on a Windows, Linux or Mac APACHE server connected to a private or public network (http://mamsap.it.deakin.edu.au/~pcc/Release/EXP_PAC.html). Copyright © 2012 Elsevier Inc. All rights reserved.

  14. Analysis of an Adaptive P-Persistent MAC Scheme for WLAN Providing Delay Fairness

    Science.gov (United States)

    Yen, Chih-Ming; Chang, Chung-Ju; Chen, Yih-Shen; Huang, Ching Yao

    The paper proposes and analyzes an adaptive p-persistent-based (APP) medium access control (MAC) scheme for IEEE 802.11 WLAN. The APP MAC scheme intends to support delay fairness for every station in each access, denoting small delay variance. It differentiates permission probabilities of transmission for stations which are incurred with various packet delays. This permission probability is designed as a function of the numbers of retransmissions and re-backoffs so that stations with larger packet delay are endowed with higher permission probability. Also, the scheme is analyzed by a Markov-chain analysis, where the collision probability, the system throughput, and the average delay are successfully obtained. Numerical results show that the proposed APP MAC scheme can attain lower mean delay and higher mean throughput. In the mean time, simulation results are given to justify the validity of the analysis, and also show that the APP MAC scheme can achieve more delay fairness than conventional algorithms.

  15. Nursery nutrition in Liverpool: an exploration of practice and nutritional analysis of food provided.

    Science.gov (United States)

    Parker, Mike; Lloyd-Williams, Ffion; Weston, Gemma; Macklin, Julie; McFadden, Kate

    2011-10-01

    To explore nutrition and food provision in pre-school nurseries in order to develop interventions to promote healthy eating in pre-school settings. Quantitative data were gathered using questionnaires and professional menu analysis. In the community, at pre-school nurseries. All 130 nurseries across Liverpool were a sent questionnaire (38 % response rate); thirty-four menus were returned for analysis (26 % response rate). Only 21 % of respondents stated they had adequate knowledge on nutrition for pre-school children. Sixty-one per cent of cooks reported having received only a 'little' advice on healthy eating and this was often not specific to under-5 s nutrition. Fifty-seven per cent of nurseries did not regularly assess their menus for nutritional quality. The menu analysis revealed that all menus were deficient in energy, carbohydrate, Fe and Zn. Eighty-five per cent of nurseries had Na/salt levels which exceed guidelines. Nurseries require support on healthy eating at policy, knowledge and training levels. This support should address concerns relating to both menu planning and ingredients used in food provision and meet current guidelines on food provision for the under-5 s.

  16. Issues in the Analysis of Focus Groups: Generalisability, Quantifiability, Treatment of Context and Quotations

    Science.gov (United States)

    Vicsek, Lilla

    2010-01-01

    In this paper I discuss some concerns related to the analysis of focus groups: (a) the issue of generalisation; (b) the problems of using numbers and quantifying in the analysis; (c) how the concrete situation of the focus groups could be included in the analysis, and (d) what formats can be used when quoting from focus groups. Problems with…

  17. Analysis of pharmacist-provided medication therapy management (MTM) services in community pharmacies over 7 years.

    Science.gov (United States)

    Barnett, Mitchell J; Frank, Jessica; Wehring, Heidi; Newland, Brand; VonMuenster, Shannon; Kumbera, Patty; Halterman, Tom; Perry, Paul J

    2009-01-01

    Although community pharmacists have historically been paid primarily for drug distribution and dispensing services, medication therapy management (MTM) services evolved in the 1990s as a means for pharmacists and other providers to assist physicians and patients in managing clinical, service, and cost outcomes of drug therapy. The Medicare Prescription Drug, Improvement, and Modernization Act of 2003 (MMA 2003) and the subsequent implementation of Medicare Part D in January 2006 for the more than 20 million Medicare beneficiaries enrolled in the Part D benefit formalized MTM services for a subset of high-cost patients. Although Medicare Part D has provided a new opportunity for defining the value of pharmacist-provided MTM services in the health care system, few publications exist which quantify changes in the provision of pharmacist-provided MTM services over time. To (a) describe the changes over a 7-year period in the primary types of MTM services provided by community pharmacies that have contracted with drug plan sponsors through an MTM administrative services company, and (b) quantify potential MTM-related cost savings based on pharmacists' self-assessments of the likely effects of their interventions on health care utilization. Medication therapy management claims from a multistate MTM administrative services company were analyzed over the 7-year period from January 1, 2000, through December 31, 2006. Data extracted from each MTM claim included patient demographics (e.g., age and gender), the drug and type that triggered the intervention (e.g., drug therapeutic class and therapy type as either acute, intermittent, or chronic), and specific information about the service provided (e.g., Reason, Action, Result, and Estimated Cost Avoidance [ECA]). ECA values are derived from average national health care utilization costs, which are applied to pharmacist self-assessment of the "reasonable and foreseeable" outcome of the intervention. ECA values are updated

  18. A schema theory analysis of students' think aloud protocols in an STS biology context

    Science.gov (United States)

    Quinlan, Catherine Louise

    This dissertation study is a conglomerate of the fields of Science Education and Applied Cognitive Psychology. The goal of this study is to determine what organizational features and knowledge representation patterns high school students exhibit over time for issues pertinent to science and society. Participants are thirteen tenth grade students in a diverse suburban-urban classroom in a northeastern state. Students' think alouds are recorded, pre-, post-, and late-post treatment. Treatment consists of instruction in three Science, Technology, and Society (STS) biology issues, namely the human genome project, nutrition and health, and stem cell research. Coding and analyses are performed using Marshall's knowledge representations---identification knowledge, elaboration knowledge, planning knowledge, and execution knowledge, as well as qualitative research analysis methods. Schema theory, information processing theory, and other applied cognitive theory provide a framework in which to understand and explain students' schema descriptions and progressions over time. The results show that students display five organizational features in their identification and elaboration knowledge. Students also fall into one of four categories according to if they display prior schema or no prior schema, and their orientation "for" or "against," some of the issues. Students with prior schema and orientation "against" display the most robust schema descriptions and schema progressions. Those with no prior schemas and orientation "against" show very modest schema progressions best characterized by their keyword searches. This study shows the importance in considering not only students' integrated schemas but also their individual schemes. A role for the use of a more schema-based instruction that scaffolds student learning is implicated.

  19. Identification of physicians providing comprehensive primary care in Ontario: a retrospective analysis using linked administrative data.

    Science.gov (United States)

    Schultz, Susan E; Glazier, Richard H

    2017-12-19

    Given the changing landscape of primary care, there may be fewer primary care physicians available to provide a broad range of services to patients of all age groups and health conditions. We sought to identify physicians with comprehensive primary care practices in Ontario using administrative data, investigating how many and what proportion of primary care physicians provided comprehensive primary care and how this changed over time. We identified the pool of active primary care physicians in linked population-based databases for Ontario from 1992/93 to 2014/15. After excluding those who saw patients fewer than 44 days per year, we identified physicians as providing comprehensive care if more than half of their services were for core primary care and if these services fell into at least 7 of 22 activity areas. Physicians with 50% or less of their services for core primary care but with more than 50% in a single location or type of service were identified as being in focused practice. In 2014/15, there were 12 891 physicians in the primary care pool: 1254 (9.7%) worked fewer than 44 days per year, 1619 (12.6%) were in focused practice, and 1009 (7.8%) could not be classified. The proportion in comprehensive practice ranged from 67.5% to 74.9% between 1992/93 and 2014/15, with a peak in 2002/03 and relative stability from 2009/10 to 2014/15. Over this period, there was an increase of 8.8% in population per comprehensive primary care physician. We found that just over two-thirds of primary care physicians provided comprehensive care in 2014/15, which indicates that traditional estimates of the primary care physician workforce may be too high. Although implementation will vary by setting and available data, this approach is likely applicable elsewhere. Copyright 2017, Joule Inc. or its licensors.

  20. Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

    Directory of Open Access Journals (Sweden)

    Hua-Sheng Chiu

    2018-04-01

    Full Text Available Summary: Long noncoding RNAs (lncRNAs are commonly dysregulated in tumors, but only a handful are known to play pathophysiological roles in cancer. We inferred lncRNAs that dysregulate cancer pathways, oncogenes, and tumor suppressors (cancer genes by modeling their effects on the activity of transcription factors, RNA-binding proteins, and microRNAs in 5,185 TCGA tumors and 1,019 ENCODE assays. Our predictions included hundreds of candidate onco- and tumor-suppressor lncRNAs (cancer lncRNAs whose somatic alterations account for the dysregulation of dozens of cancer genes and pathways in each of 14 tumor contexts. To demonstrate proof of concept, we showed that perturbations targeting OIP5-AS1 (an inferred tumor suppressor and TUG1 and WT1-AS (inferred onco-lncRNAs dysregulated cancer genes and altered proliferation of breast and gynecologic cancer cells. Our analysis indicates that, although most lncRNAs are dysregulated in a tumor-specific manner, some, including OIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergistically dysregulate cancer pathways in multiple tumor contexts. : Chiu et al. present a pan-cancer analysis of lncRNA regulatory interactions. They suggest that the dysregulation of hundreds of lncRNAs target and alter the expression of cancer genes and pathways in each tumor context. This implies that hundreds of lncRNAs can alter tumor phenotypes in each tumor context. Keywords: lncRNA, regulation, modulation, cancer gene, pan-cancer, noncoding RNA, microRNA, RNA-binding proteins, interactome

  1. Creating a market: an economic analysis of the purchaser-provider model.

    Science.gov (United States)

    Shackley, P; Healey, A

    1993-09-01

    The focus of this paper is the extent to which the purchaser-provider split and the creation of a market in the provision of health care can be expected to bring about greater efficiency within the new NHS. The starting point is a theoretical discussion of markets and competition. In particular, emphasis is placed upon the economic model of perfect competition. It is argued that because of the existence of externalities, uncertainty and a lack of perfect information, an unregulated market in health care will almost certainly fail. In view of this, the imperfect provider markets of monopoly and contestable markets, which are of particular relevance to health care, are discussed. A description of the new health care market and the principal actors within it is followed by an evaluation of the new health care market. It is argued that in view of the restrictions to competition that exist between providers, some form of price regulation will be necessary to prevent monopolistic behaviour in the hospital sector. Regulation of purchasers is also suggested as a means of improving efficiency. It is concluded that competition may be a necessary condition for increased efficiency in health care provision, but is not sufficient in itself. Other incentives in the hospital sector are necessary to assist the market process and to enhance its impact on efficiency.

  2. [Self-owned versus accredited network: comparative cost analysis in a Brazilian health insurance provider].

    Science.gov (United States)

    Souza, Marcos Antônio de; Salvalaio, Dalva

    2010-10-01

    to analyze the cost of a self-owned network maintained by a Brazilian health insurance provider as compared to the price charged by accredited service providers, so as to identify whether or not the self-owned network is economically advantageous. for this exploratory study, the company's management reports were reviewed. The cost associated with the self-owned network was calculated based on medical and dental office visits and diagnostic/laboratory tests performed at one of the company's most representative facilities. The costs associated with third parties were derived from price tables used by the accredited network for the same services analyzed in the self-owned network. The full-cost method was used for cost quantification. Costs are presented as absolute values (in R$) and percent comparisons between self-owned network costs versus accredited network costs. overall, the self-owned network was advantageous for medical and dental consultations as well as diagnostic and laboratory tests. Pediatric and labor medicine consultations and x-rays were less costly in the accredited network. the choice of verticalization has economic advantages for the health care insurance operator in comparison with services provided by third parties.

  3. Competence in providing mental health care: a grounded theory analysis of nurses' experiences.

    Science.gov (United States)

    Sharrock, Julie; Happell, Brenda

    In view of the evidence that general nurses have difficulty in caring for patients experiencing mental health problems, the aim of this study was to explore and describe the subjective experience of nurses in providing care for this client group. A grounded theory approach was used. The data were collected via semi-structured individual interviews and analysed using the constant comparative method. The study was conducted with nurses from general health care settings that provide medical and surgical care and treatment. Four nurses who were completing their second year post graduation participated in the study. The experiences of providing care for people experiencing a mental illness as described by participants. The findings indicated the nurses were striving for competence in the provision of mental health care. They acknowledged the mental health needs of patients and their right to quality care. This study supports the notion that general nurses lack confidence when caring for patients with mental health problems in medical and surgical settings. It also highlights a discrepancy between the holistic framework encouraged at undergraduate level and what is experienced in practice.

  4. A qualitative analysis of job burnout in eating disorder treatment providers.

    Science.gov (United States)

    Warren, Cortney S; Schafer, Kerri J; Crowley, Mary Ellen; Olivardia, Roberto

    2012-01-01

    Although job burnout is common in mental health care settings, almost no research has examined burnout in eating disorder treatment providers. Using qualitative methodology, this study examined a) perceived contributors of burnout, b) efforts to manage burnout, and c) recommendations for avoiding burnout in a sample of professional eating disorder treatment providers. Recruited via professional organizations, 298 participants completed an online questionnaire designed by the authors. Qualitative responses were coded and grouped into themes. Results indicated that almost all participants worried about their patients' health, which frequently resulted in negative affect (e.g., anxiety, sadness). The most frequently cited contributors to burnout were common characteristics of eating pathology (e.g., chronicity, relapse, symptom severity); patient characteristics (e.g., personality conflict); work-related factors (e.g., time demands); and, financial issues (e.g., inadequate compensation). To avoid burnout, over 90% of participants engaged in self-care behaviors (e.g., exercise, social support). Early-career practitioners were encouraged to utilize supervision, create a work/life balance, engage in self-care, and limit caseloads. These results suggest that supervision and training of eating disorder treatment providers should include burnout management.

  5. Toward a more comprehensive analysis of the role of organizational culture in child sexual abuse in institutional contexts.

    Science.gov (United States)

    Palmer, Donald; Feldman, Valerie

    2017-12-01

    This article draws on a report prepared for the Australian Royal Commission into Institutional Responses to Child Sexual Abuse (Palmer et al., 2016) to develop a more comprehensive analysis of the role that organizational culture plays in child sexual abuse in institutional contexts, where institutional contexts are taken to be formal organizations that include children among their members (referred to here as "youth-serving organizations"). We begin by integrating five strains of theory and research on organizational culture from organizational sociology and management theory into a unified framework for analysis. We then elaborate the main paths through which organizational culture can influence child sexual abuse in youth-serving organizations. We then use our unified analytic framework and our understanding of the main paths through which organizational culture can influence child sexual abuse in youth-serving organizations to analyze the role that organizational culture plays in the perpetration, detection, and response to child sexual abuse in youth-serving organizations. We selectively illustrate our analysis with case materials compiled by the Royal Commission into Institutional Responses to Child Sexual Abuse and reports of child sexual abuse published in a variety of other sources. We conclude with a brief discussion of the policy implications of our analysis. Copyright © 2017. Published by Elsevier Ltd.

  6. Comparative proteomic analysis provides insight into cadmium stress responses in brown algae Sargassum fusiforme

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Aiqin; Xu, Tao [Alkali Soil Natural Environmental Science Center, Northeast Forestry University, Key Laboratory of Saline–alkali Vegetation Ecology Restoration in Oil Field, Ministry of Education, Harbin 150040 (China); Zou, Huixi [Zhejiang Provincial Key Laboratory for Subtropical Water Environment and Marine Biological Resources Protection, College of Life and Environmental Science, Wenzhou University, Wenzhou 325035 (China); Pang, Qiuying, E-mail: qiuying@nefu.edu.cn [Alkali Soil Natural Environmental Science Center, Northeast Forestry University, Key Laboratory of Saline–alkali Vegetation Ecology Restoration in Oil Field, Ministry of Education, Harbin 150040 (China)

    2015-06-15

    Highlights: • Proteomic analysis of brown algae response different level Cd stress was performed. • Proteins involved in carbohydrate metabolism were reduced under 1 day Cd stress. • 5 days Cd stress induced glycolysis and citrate cycle related proteins. • Graphic depiction of different metabolic pathways response to Cd stress was framed. - Abstract: Sargassum fusiforme is one of the most widely consumed seaweeds in China, Korea and Japan. In this work, we performed growth analysis and comparative proteomics to investigate the molecular mechanisms of the response to 1 day and 5 days Cd stress in S. fusiforme. Our results showed a significant decrease in growth rate and an increase in Cd ion content in S. fusiforme in response to Cd treatment. Comparative proteomic analysis revealed 25 and 51 differentially expressed protein spots in S. fusiforme under 1 day and 5 days Cd stress, respectively. A great number of these proteins was metabolic enzymes involved in carbohydrate metabolism and energy metabolism. Many proteins involved in the processing of genetic information showed a decrease in abundance under 1 day Cd stress. In contrast, 9 of the identified protein spots primarily involved in genetic information processing and carbohydrate metabolism were greatly enriched under 5 days Cd stress. Overall, our investigation indicated that Cd stress negatively affects the metabolic activity of S. fusiforme through the down-regulation of key metabolic enzymes. In addition, S. fusiforme may adapt to 5 days Cd stress by promoting consumption of photoassimilates through the up-regulation of glycolysis and the citrate cycle to supply energy for survival.

  7. Comparative proteomic analysis provides insight into cadmium stress responses in brown algae Sargassum fusiforme

    International Nuclear Information System (INIS)

    Zhang, Aiqin; Xu, Tao; Zou, Huixi; Pang, Qiuying

    2015-01-01

    Highlights: • Proteomic analysis of brown algae response different level Cd stress was performed. • Proteins involved in carbohydrate metabolism were reduced under 1 day Cd stress. • 5 days Cd stress induced glycolysis and citrate cycle related proteins. • Graphic depiction of different metabolic pathways response to Cd stress was framed. - Abstract: Sargassum fusiforme is one of the most widely consumed seaweeds in China, Korea and Japan. In this work, we performed growth analysis and comparative proteomics to investigate the molecular mechanisms of the response to 1 day and 5 days Cd stress in S. fusiforme. Our results showed a significant decrease in growth rate and an increase in Cd ion content in S. fusiforme in response to Cd treatment. Comparative proteomic analysis revealed 25 and 51 differentially expressed protein spots in S. fusiforme under 1 day and 5 days Cd stress, respectively. A great number of these proteins was metabolic enzymes involved in carbohydrate metabolism and energy metabolism. Many proteins involved in the processing of genetic information showed a decrease in abundance under 1 day Cd stress. In contrast, 9 of the identified protein spots primarily involved in genetic information processing and carbohydrate metabolism were greatly enriched under 5 days Cd stress. Overall, our investigation indicated that Cd stress negatively affects the metabolic activity of S. fusiforme through the down-regulation of key metabolic enzymes. In addition, S. fusiforme may adapt to 5 days Cd stress by promoting consumption of photoassimilates through the up-regulation of glycolysis and the citrate cycle to supply energy for survival

  8. Maintenance of health care providers clinical proficiency: Transdisciplinary analysis, modeling and intervention

    Science.gov (United States)

    2015-10-13

    Auscultation/Cardio 4.2.3 Auscultation/GI 4.2.4 Shape of face 4.2.5 Skin color (Neck, axillar) 4.2.6 Hip Exam 4.2.7 Weight 4.2.8 Stature 5.0 Treatment... vegetables , spend no more than 2 hours on screen time, include 1 hour of physical activity or active play, and consume little or no sugar-sweetened...learning environments, logistics analysis, and enterprise operational analytics. Ms. Ingraham also works on the application of artificial intelligence

  9. Elaboration of the methodological referential for life cycle analysis of first generation biofuels in the French context

    International Nuclear Information System (INIS)

    2008-01-01

    This study was made under the particular context of a strong growth of biofuels market, and the implication of French and European public authorities, and certain Member States (Germany, Netherlands, UK), for the development of certification schemes for first generation biofuels. The elaboration of such schemes requires a consensus on the methodology to apply when producing Life Cycle Analysis (LCA) of biofuels. To answer this demand, the study built up the methodological referential for biofuels LCAs in order to assess the Greenhouse Gases (GHG) emissions, fossil fuels consumptions and local atmospheric pollutants emissions induced by the different biofuel production pathways. The work consisted in methodological engineering, and was accomplished thanks to the participation of all the members of the Technical Committee of the study. An initial bibliographic review on biofuels LCAs allowed the identification of the main methodological issues (listed below). For each point, the impact of the methodological choices on the biofuels environmental balances was assessed by several sensitivity analyses. The results of these analyses were taken into account for the elaboration of the recommendations: - Consideration of the environmental burdens associated with buildings, equipments and their maintenance - Quantification of nitrous oxide (N 2 O) emissions from fields - Impact of the Land Use Change (LUC) - Allocation method for the distribution of the environmental impacts of biofuel production pathways between the different products and coproducts generated. Within the framework of this study, we made no distinction in terms of methodological approach between GHG emissions and local pollutants emissions. This results from the fact that the methodological issues cover all the environmental burdens and do not require specific approaches. This executive summary presents the methodological aspects related to biofuels LCAs. The complete report of the study presents in addition

  10. Does Context Matter? An Analysis of Training in Multicultural Assessment, Consultation, and Intervention between School Psychologists in Urban and Rural Contexts

    Science.gov (United States)

    Newell, Markeda; Looser, Joshua

    2018-01-01

    The purpose of this study was to analyze the extent of training in multicultural assessment, intervention, and consultation of school psychologists in urban and rural contexts. Although there is greater cultural and sociodemographic diversity in urban settings as compared to rural settings, it is unknown whether school psychologists in urban…

  11. Providers' Access of Imaging Versus Only Reports: A System Log File Analysis.

    Science.gov (United States)

    Jung, Hye-Young; Gichoya, Judy Wawira; Vest, Joshua R

    2017-02-01

    An increasing number of technologies allow providers to access the results of imaging studies. This study examined differences in access of radiology images compared with text-only reports through a health information exchange system by health care professionals. The study sample included 157,256 historical sessions from a health information exchange system that enabled 1,670 physicians and non-physicians to access text-based reports and imaging over the period 2013 to 2014. The primary outcome was an indicator of access of an imaging study instead of access of a text-only report. Multilevel mixed-effects regression models were used to estimate the association between provider and session characteristics and access of images compared with text-only reports. Compared with primary care physicians, specialists had an 18% higher probability of accessing actual images instead of text-only reports (β = 0.18; P < .001). Compared with primary care practice settings, the probability of accessing images was 4% higher for specialty care practices (P < .05) and 8% lower for emergency departments (P < .05). Radiologists, orthopedists, and neurologists accounted for 79% of all the sessions with actual images accessed. Orthopedists, radiologists, surgeons, and pulmonary disease specialists accessed imaging more often than text-based reports only. Consideration for differences in the need to access images compared with text-only reports based on the type of provider and setting of care are needed to maximize the benefits of image sharing for patient care. Copyright © 2016 American College of Radiology. Published by Elsevier Inc. All rights reserved.

  12. Computerized analysis of isometric tension studies provides important additional information about vasomotor activity

    Directory of Open Access Journals (Sweden)

    Vincent M.B.

    1997-01-01

    Full Text Available Concentration-response curves of isometric tension studies on isolated blood vessels are obtained traditionally. Although parameters such as Imax, EC50 and pA2 may be readily calculated, this method does not provide information on the temporal profile of the responses or the actual nature of the reaction curves. Computerized data acquisition systems can be used to obtain average data that represent a new source of otherwise inaccessible information, since early and late responses may be observed separately in detail

  13. TRANSIT: model for providing generic transportation input for preliminary siting analysis

    International Nuclear Information System (INIS)

    McNair, G.W.; Cashwell, J.W.

    1985-02-01

    To assist the US Department of Energy's efforts in potential facility site screening in the nuclear waste management program, a computerized model, TRANSIT, is being developed. Utilizing existing data on the location and inventory characteristics of spent nuclear fuel at reactor sites, TRANSIT derives isopleths of transportation mileage, costs, risks and fleet requirements for shipments to storage sites and/or repository sites. This technique provides a graphic, first-order method for use by the Department in future site screening efforts. 2 refs

  14. Business Intelligence. A Presentation of the Current Lead Solutions and a Comparative Analysis of the Main Providers

    Directory of Open Access Journals (Sweden)

    Bogdan-Andrei IONESCU

    2014-09-01

    Full Text Available The aim of this paper is to synthesize the concepts behind Business Intelligence, by studying the solutions available on the market provided by the main players. We will present the software solutions already provided by them emphasizing the main advantages and benefits of each of them, but also as a comparative analysis, designed to reveal the area in which each provider is more remarkable than the others.

  15. Genome analysis of Hibiscus syriacus provides insights of polyploidization and indeterminate flowering in woody plants.

    Science.gov (United States)

    Kim, Yong-Min; Kim, Seungill; Koo, Namjin; Shin, Ah-Young; Yeom, Seon-In; Seo, Eunyoung; Park, Seong-Jin; Kang, Won-Hee; Kim, Myung-Shin; Park, Jieun; Jang, Insu; Kim, Pan-Gyu; Byeon, Iksu; Kim, Min-Seo; Choi, JinHyuk; Ko, Gunhwan; Hwang, JiHye; Yang, Tae-Jin; Choi, Sang-Bong; Lee, Je Min; Lim, Ki-Byung; Lee, Jungho; Choi, Ik-Young; Park, Beom-Seok; Kwon, Suk-Yoon; Choi, Doil; Kim, Ryan W

    2017-02-01

    Hibiscus syriacus (L.) (rose of Sharon) is one of the most widespread garden shrubs in the world. We report a draft of the H. syriacus genome comprised of a 1.75 Gb assembly that covers 92% of the genome with only 1.7% (33 Mb) gap sequences. Predicted gene modeling detected 87,603 genes, mostly supported by deep RNA sequencing data. To define gene family distribution among relatives of H. syriacus, orthologous gene sets containing 164,660 genes in 21,472 clusters were identified by OrthoMCL analysis of five plant species, including H. syriacus, Arabidopsis thaliana, Gossypium raimondii, Theobroma cacao and Amborella trichopoda. We inferred their evolutionary relationships based on divergence times among Malvaceae plant genes and found that gene families involved in flowering regulation and disease resistance were more highly divergent and expanded in H. syriacus than in its close relatives, G. raimondii (DD) and T. cacao. Clustered gene families and gene collinearity analysis revealed that two recent rounds of whole-genome duplication were followed by diploidization of the H. syriacus genome after speciation. Copy number variation and phylogenetic divergence indicates that WGDs and subsequent diploidization led to unequal duplication and deletion of flowering-related genes in H. syriacus and may affect its unique floral morphology. © The Author 2016. Published by Oxford University Press on behalf of Kazusa DNA Research Institute.

  16. Integrated sequence analysis pipeline provides one-stop solution for identifying disease-causing mutations.

    Science.gov (United States)

    Hu, Hao; Wienker, Thomas F; Musante, Luciana; Kalscheuer, Vera M; Kahrizi, Kimia; Najmabadi, Hossein; Ropers, H Hilger

    2014-12-01

    Next-generation sequencing has greatly accelerated the search for disease-causing defects, but even for experts the data analysis can be a major challenge. To facilitate the data processing in a clinical setting, we have developed a novel medical resequencing analysis pipeline (MERAP). MERAP assesses the quality of sequencing, and has optimized capacity for calling variants, including single-nucleotide variants, insertions and deletions, copy-number variation, and other structural variants. MERAP identifies polymorphic and known causal variants by filtering against public domain databases, and flags nonsynonymous and splice-site changes. MERAP uses a logistic model to estimate the causal likelihood of a given missense variant. MERAP considers the relevant information such as phenotype and interaction with known disease-causing genes. MERAP compares favorably with GATK, one of the widely used tools, because of its higher sensitivity for detecting indels, its easy installation, and its economical use of computational resources. Upon testing more than 1,200 individuals with mutations in known and novel disease genes, MERAP proved highly reliable, as illustrated here for five families with disease-causing variants. We believe that the clinical implementation of MERAP will expedite the diagnostic process of many disease-causing defects. © 2014 WILEY PERIODICALS, INC.

  17. Comparative transcriptional analysis provides new insights into the molecular basis of adventitious rooting recalcitrance in Eucalyptus.

    Science.gov (United States)

    de Almeida, Márcia Rodrigues; de Bastiani, Daniela; Gaeta, Marcos Letaif; de Araújo Mariath, Jorge Ernesto; de Costa, Fernanda; Retallick, Jeffrey; Nolan, Lana; Tai, Helen H; Strömvik, Martina V; Fett-Neto, Arthur Germano

    2015-10-01

    Adventitious rooting (AR) is essential in clonal propagation. Eucalyptus globulus is relevant for the cellulose industry due to its low lignin content. However, several useful clones are recalcitrant to AR, often requiring exogenous auxin, adding cost to clonal garden operations. In contrast, E. grandis is an easy-to-root species widely used in clonal forestry. Aiming at contributing to the elucidation of recalcitrance causes in E. globulus, we conducted a comparative analysis with these two species differing in rooting competence, combining gene expression and anatomical techniques. Recalcitrance in E. globulus is reversed by exposure to exogenous indole-3-acetic acid (IAA), which promotes important gene expression modifications in both species. The endogenous content of IAA was significantly higher in E. grandis than in E. globulus. The cambium zone was identified as an active area during AR, concentrating the first cell divisions. Immunolocalization assay showed auxin accumulation in cambium cells, further indicating the importance of this region for rooting. We then performed a cambium zone-specific gene expression analysis during AR using laser microdissection. The results indicated that the auxin-related genes TOPLESS and IAA12/BODENLOS and the cytokinin-related gene ARR1may act as negative regulators of AR, possibly contributing to the hard-to-root phenotype of E. globulus. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  18. Uncertainty as Knowledge: Constraints on Policy Choices Provided by Analysis of Uncertainty

    Science.gov (United States)

    Lewandowsky, S.; Risbey, J.; Smithson, M.; Newell, B. R.

    2012-12-01

    Uncertainty forms an integral part of climate science, and it is often cited in connection with arguments against mitigative action. We argue that an analysis of uncertainty must consider existing knowledge as well as uncertainty, and the two must be evaluated with respect to the outcomes and risks associated with possible policy options. Although risk judgments are inherently subjective, an analysis of the role of uncertainty within the climate system yields two constraints that are robust to a broad range of assumptions. Those constraints are that (a) greater uncertainty about the climate system is necessarily associated with greater expected damages from warming, and (b) greater uncertainty translates into a greater risk of the failure of mitigation efforts. These ordinal constraints are unaffected by subjective or cultural risk-perception factors, they are independent of the discount rate, and they are independent of the magnitude of the estimate for climate sensitivity. The constraints mean that any appeal to uncertainty must imply a stronger, rather than weaker, need to cut greenhouse gas emissions than in the absence of uncertainty.

  19. Understanding Specific Contexts of Antiretroviral Therapy Adherence in Rural South Africa: A Thematic Analysis of Digital Stories from a Community with High HIV Prevalence.

    Directory of Open Access Journals (Sweden)

    Astrid Treffry-Goatley

    Full Text Available Near-perfect adherence to antiretroviral therapy (ART is required to achieve the best possible prevention and treatment outcomes. Yet, there have been particular concerns about the challenges of adherence among patients living in resource-limited settings in sub-Saharan Africa. The primary objective of this study was to explore adherence in a low-resourced, rural community of high HIV prevalence in South Africa and to identify specific individual and structural factors that can either challenge or support adherence in this context. We applied digital stories as a qualitative research tool to gain insights into personal contexts of HIV and ART adherence. Through an inductive thematic analysis of twenty story texts, soundtracks and drawings, we explored experiences, understandings, and contexts of the participants and identified potential barriers and facilitators for those on lifelong treatment. We found that many of the stories reflected a growing confidence in the effectiveness of ART, which should be viewed as a key facilitator to successful adherence since this attitude can promote disclosure and boost access to social support. Nevertheless, stories also highlighted the complexity of the issues that individuals and households face as they deal with HIV and ART in this setting and it is clear that an overburdened local healthcare system has often struggled to meet the demands of a rapidly expanding epidemic and to provide the necessary medical and emotional support. Our analysis suggests several opportunities for further research and the design of novel health interventions to support optimal adherence. Firstly, future health promotion campaigns should encourage individuals to test together, or at least accompany each other for testing, to encourage social support from the outset. Additionally, home-based testing and ART club interventions might be recommended to make it easier for individuals to adhere to their treatment regimens and to

  20. Control and Regulation of Private Security Providers in Latin America and the Caribbean: A Comparative Analysis

    Directory of Open Access Journals (Sweden)

    Francesca Caonero

    2014-05-01

    Full Text Available States and different international players have drafted legal frameworks to adequately regulate the phenomenon of privatization of security. Among these initiatives is the Project for a Possible Convention on Private Military and Security Companies, prepared with guidance from the United Nations Human Rights Council. The objective of this proposed convention is to provide a universal framework to regulate these companies.The United Nations Regional Center for Peace, Disarmament and Development in Latin America and the Caribbean (UNLIREC has studied this Proposed Convention and contrasted it with existing national regulations. The objective of this study is to identify whether and how States already comply with some of the provisions contained in this proposal.Based on the study of national private security law, UNLIREC has contrasted it with the Convention Proposal identifying the different items in this document that are referred to in the different national regulations from various countries in Latin America and the Caribbean.As a result of this legal contrast, it can be observed that laws in some States in the region include significant legal aspects put forth in the Proposed Convention, such as licenses, registry and training. Other States go beyond that, stipulating specific regulations that can be noted. Others, on the contrary, lack any provisions regarding control and regulation of private security providers.DOI: http://dx.doi.org/10.5377/rpsp.v1i1.1392

  1. How doing a dynamical analysis of gait movement may provide information about Autism

    Science.gov (United States)

    Wu, D.; Torres, E.; Nguyen, J.; Mistry, S.; Whyatt, C.; Kalampratsidou, V.; Kolevzon, A.; Jose, J.

    Individuals with Autism Spectrum Disorder (ASD) are known to have deficits in language and social skills. They also have deficits on how they move. Why individuals get ASD? It is not generally known. There is, however, one particular group of children with a SHANK3 gene deficiency (Phelan-McDermid Syndrome (PMDS)) that present symptoms similar to ASD. We have been searching for universal mechanism in ASD going beyond the usual heterogeneous ASD symptoms. We studied motions in gaits for both PMDS patients and idiopathic ASD. We have examined their motions continuously at milliseconds time scale, away from naked eye detection. Gait is a complex process, requiring a complex integration and coordination of different joints' motions. Significant information about the development and/or deficits in the sensory system is hidden in our gaits. We discovered that the speed smoothness in feet motion during gaits is a critical feature that provides a significant distinction between subjects with ASD and typical controls. The differences in appearance of the speed fluctuations suggested a different coordination mechanism in subjects with disorders. Our work provides a very important feature in gait motion that has significant physiological information.

  2. Comparative transcriptome analysis provides new insights into erect and prostrate growth in bermudagrass (Cynodon dactylon L.).

    Science.gov (United States)

    Zhang, Bing; Xiao, Xiaolin; Zong, Junqin; Chen, Jingbo; Li, Jianjian; Guo, Hailin; Liu, Jianxiu

    2017-12-01

    Bermudagrass (Cynodon dactylon L.) is a prominent warm-season turf and forage grass species with multiple applications. In most C. dactylon cultivars and accessions, erect-growing stems (shoot) and prostrate-growing stems (stolon) often coexist. These two types of stems are both formed through tillering but grow in two directions with different tiller angles. Elucidating the mechanism of tiller angle regulation in bermudagrass could provide important clues to breed cultivars with different plant architectural features for diverse usage. In this study, we compared the stem internode transcriptome of two bermudagrass wild accessions with extremely different tiller angles and stem growth directions. A total of 2088 and 12,141 unigenes were preferentially expressed in prostrate-growing wild accession C792 and erect-growing wild accession C793, respectively. Kyoto Encyclopedia of Genes and Genomes (KEGG) Orthology-based Annotation System (KOBAS) analyses further indicated that light- and gravity-responsive genes were enriched in accession C792, whereas lignin synthesis-related genes were enriched in accession C793, which well explains the difference in lignification of vascular bundles and mechanical tissues in the two accessions. These results not only expand our understanding of the genetic control of tiller angle and stem growth direction in bermudagrass but also provide insight for future molecular breeding of C. dactylon and other turfgrass species with different plant architectures. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  3. Analysis of Log File Data to Understand Mobile Service Context and Usage Patterns

    Directory of Open Access Journals (Sweden)

    Bernhard Klein

    2013-09-01

    Full Text Available Several mobile acceptance models exist today that focus on user interface handling and usage frequency evaluation. Since mobile applications reach much deeper into everyday life, it is however important to better consider user behaviour for the service evaluation. In this paper we introduce the Behaviour Assessment Model (BAM, which is designed to gaining insights about how well services enable, enhance and replace human activities. More specifically, the basic columns of the evaluation framework concentrate on (1 service actuation in relation to the current user context, (2 the balance between service usage effort and benefit, and (3 the degree to which community knowledge can be exploited. The evaluation is guided by a process model that specifies individual steps of data capturing, aggregation, and final assessment. The BAM helps to gain stronger insights regarding characteristic usage hotspots, frequent usage patterns, and leveraging of networking effects showing more realistically the strengths and weaknesses of mobile services

  4. Science & Technology, Development and Local Power: Elements for Analysis of the Brazilian Context

    Directory of Open Access Journals (Sweden)

    Sueli Goulart

    2007-03-01

    Full Text Available This paper discusses the theoretical aspects of the relationship between scientific and technological production of universities and local development. The central argument is that this relationship is potentialized when produced knowledge permits the occupation of a position in the scientific field and is linked to specific forms of local insertion. In the context of globalization, which keeps the center-periphery structure of the world economic system practically intact, articulation is proposed between global and local dimensions of the environment. The recovery of theoretical-empirical categories formulated by Economic Commission for Latin-America and the Caribbean helps to place the discussion in a political sphere, and to characterize local development as an expression of social change on territorially demarcated scales.

  5. Shadow Economy in the Context of Economic Crisis: Circumstance Analysis and the Forecasting of Consequences

    Directory of Open Access Journals (Sweden)

    Alexey Sergeyevich Naidenov

    2013-03-01

    Full Text Available The article is devoted to the problem of estimating dynamic of shadow economy in the context of socio-economic crisis negative influence. Factors and threats supporting the increase of shadow economy during the economic crisis were studied. Current situation in the Ural Federal District with regard to shadow economic activity for the period from 2006 to 2012 was represented. The results of forecasting shadow activity were given in the article on the example of Ural Federal District regions. Data obtained was used for developing target program activities, aimed at minimization of negative influence of shadow economy during the economic crisis. Special attention was given to the problem of improving the effectiveness of international cooperation concerning counteraction of shadow economic activity

  6. Positioning Analysis of Filipino Family Narratives in the Context of Prisoner Reintegration

    Directory of Open Access Journals (Sweden)

    Donald Jay Bertulfo

    2016-11-01

    Full Text Available Prisoner reintegration may be viewed as a crisis situation that may lead to a period of instability within the family. Existing researches in this area remain focused on the individual perspective of ex-offenders rather than the experiences of receiving families back in their households. In this study, we aim to examine the reintegration experiences of the family as a group from an initial state of chaos to equilibrium upon the reentry of an incarcerated parent. Using a sample of 12 interviews of family members left behind by incarcerated fathers, three major storylines relating to the family’s struggle for moral re-ascendancy in the context of parental reintegration are identified: othering, rehabilitation, and restoration. We explain the interlocking emotional, discursive, and material forms of labor embedded in the process of prisoner reintegration. Policy implications on social and institutional aid to the families of reintegrating fathers are also discussed.

  7. Secondary emission ion analyzer provided with an electron gun for insulating material analysis

    International Nuclear Information System (INIS)

    Blanchard, Bruno; Carrier, Patrick; Marguerite, J.-L.; Rocco, J.-C.

    1976-01-01

    This invention relates to a secondary emission ion analyser, fitted with an electron gun. It is used in the mass spectrometry analysis of electrically insulating bodies. It has already been suggested to bombard the target with an electron beam in conjunction with the beam of primary particles, in order to reduce the space charge near the target. The object of this invention is the application of this known process to appliances of the ion analyser type with a high electric field near the target. Its main characteristic is the use of an electron gun emitting an electron beam through the extraction lens placed opposite the target. The extraction electric field influences the path of the electrons but the electric and mechanical specifications of the electron gun in the invention are such that the target is correctly sprayed by the electron beam [fr

  8. Accounting providing of statistical analysis of intangible assets renewal under marketing strategy

    Directory of Open Access Journals (Sweden)

    I.R. Polishchuk

    2016-12-01

    Full Text Available The article analyzes the content of the Regulations on accounting policies of the surveyed enterprises in terms of the operations concerning the amortization of intangible assets on the following criteria: assessment on admission, determination of useful life, the period of depreciation, residual value, depreciation method, reflection in the financial statements, a unit of account, revaluation, formation of fair value. The characteristic of factors affecting the accounting policies and determining the mechanism for evaluating the completeness and timeliness of intangible assets renewal is showed. The algorithm for selecting the method of intangible assets amortization is proposed. The knowledge base of statistical analysis of timeliness and completeness of intangible assets renewal in terms of the developed internal reporting is expanded. The statistical indicators to assess the effectiveness of the amortization policy for intangible assets are proposed. The marketing strategies depending on the condition and amount of intangible assets in relation to increasing marketing potential for continuity of economic activity are described.

  9. Analysis of the pumpkin phloem proteome provides insights into angiosperm sieve tube function.

    Science.gov (United States)

    Lin, Ming-Kuem; Lee, Young-Jin; Lough, Tony J; Phinney, Brett S; Lucas, William J

    2009-02-01

    Increasing evidence suggests that proteins present in the angiosperm sieve tube system play an important role in the long distance signaling system of plants. To identify the nature of these putatively non-cell-autonomous proteins, we adopted a large scale proteomics approach to analyze pumpkin phloem exudates. Phloem proteins were fractionated by fast protein liquid chromatography using both anion and cation exchange columns and then either in-solution or in-gel digested following further separation by SDS-PAGE. A total of 345 LC-MS/MS data sets were analyzed using a combination of Mascot and X!Tandem against the NCBI non-redundant green plant database and an extensive Cucurbit maxima expressed sequence tag database. In this analysis, 1,209 different consensi were obtained of which 1,121 could be annotated from GenBank and BLAST search analyses against three plant species, Arabidopsis thaliana, rice (Oryza sativa), and poplar (Populus trichocarpa). Gene ontology (GO) enrichment analyses identified sets of phloem proteins that function in RNA binding, mRNA translation, ubiquitin-mediated proteolysis, and macromolecular and vesicle trafficking. Our findings indicate that protein synthesis and turnover, processes that were thought to be absent in enucleate sieve elements, likely occur within the angiosperm phloem translocation stream. In addition, our GO analysis identified a set of phloem proteins that are associated with the GO term "embryonic development ending in seed dormancy"; this finding raises the intriguing question as to whether the phloem may exert some level of control over seed development. The universal significance of the phloem proteome was highlighted by conservation of the phloem proteome in species as diverse as monocots (rice), eudicots (Arabidopsis and pumpkin), and trees (poplar). These results are discussed from the perspective of the role played by the phloem proteome as an integral component of the whole plant communication system.

  10. An integrative computational analysis provides evidence for FBN1-associated network deregulation in trisomy 21

    Directory of Open Access Journals (Sweden)

    Mireia Vilardell

    2013-06-01

    Although approximately 50% of Down Syndrome (DS patients have heart abnormalities, they exhibit an overprotection against cardiac abnormalities related with the connective tissue, for example a lower risk of coronary artery disease. A recent study reported a case of a person affected by DS who carried mutations in FBN1, the gene causative for a connective tissue disorder called Marfan Syndrome (MFS. The fact that the person did not have any cardiac alterations suggested compensation effects due to DS. This observation is supported by a previous DS meta-analysis at the molecular level where we have found an overall upregulation of FBN1 (which is usually downregulated in MFS. Additionally, that result was cross-validated with independent expression data from DS heart tissue. The aim of this work is to elucidate the role of FBN1 in DS and to establish a molecular link to MFS and MFS-related syndromes using a computational approach. To reach that, we conducted different analytical approaches over two DS studies (our previous meta-analysis and independent expression data from DS heart tissue and revealed expression alterations in the FBN1 interaction network, in FBN1 co-expressed genes and FBN1-related pathways. After merging the significant results from different datasets with a Bayesian approach, we prioritized 85 genes that were able to distinguish control from DS cases. We further found evidence for several of these genes (47%, such as FBN1, DCN, and COL1A2, being dysregulated in MFS and MFS-related diseases. Consequently, we further encourage the scientific community to take into account FBN1 and its related network for the study of DS cardiovascular characteristics.

  11. Perception and analysis of the 5S program at a business service provider

    Directory of Open Access Journals (Sweden)

    André Luiz Emmel Silva

    2016-09-01

    Full Text Available Given the importance that the service sector represents in our economy, the application of concepts and techniques for its administration and models aimed at improving its quality is growing. This article aims to analyze the main aspects of the 5S program in the implementation phase and in the course of its evolution at a service company. The methodology used is qualitative, implemented through a case study structured in 6 steps. The company under study performs strongly on the national market and therefore has a large amount of documents circulating daily through different sectors, which generated the need to implement a methodology capable of streamlining document flow management and reducing the time spent on bureaucracy by its employees. The 5S program was shown to have brought the company greater administrative efficiency and a more pleasant, safe and organized working environment, motivating employees, reducing costs and providing competitive advantages.

  12. When to Stop CPR and When to Perform Rhythm Analysis: Potential Confusion Among ACLS Providers.

    Science.gov (United States)

    Giberson, Brandon; Uber, Amy; F Gaieski, David; Miller, Joseph B; Wira, Charles; Berg, Katherine; Giberson, Tyler; Cocchi, Michael N; S Abella, Benjamin; Donnino, Michael W

    2016-09-01

    Health care providers nationwide are routinely trained in Advanced Cardiac Life Support (ACLS), an American Heart Association program that teaches cardiac arrest management. Recent changes in the ACLS approach have de-emphasized routine pulse checks in an effort to promote uninterrupted chest compressions. We hypothesized that this new ACLS algorithm may lead to uncertainty regarding the appropriate action following detection of a pulse during a cardiac arrest. We conducted an observational study in which a Web-based survey was sent to ACLS-trained medical providers at 4 major urban tertiary care centers in the United States. The survey consisted of 5 multiple-choice, scenario-based ACLS questions, including our question of interest. Adult staff members with a valid ACLS certification were included. A total of 347 surveys were analyzed. The response rate was 28.1%. The majority (53.6%) of responders were between 18 and 32 years old, and 59.9% were female. The majority (54.2%) of responders incorrectly stated that they would continue CPR and possibly administer additional therapies when a team member detects a pulse immediately following defibrillation. Secondarily, only 51.9% of respondents correctly chose to perform a rhythm check following 2 minutes of CPR. The other 3 survey questions were correctly answered an average of 89.1% of the time. Confusion exists regarding whether or not CPR and cardiac medications should be continued in the presence of a pulse. Education may be warranted to emphasize avoiding compressions and medications when a palpable pulse is detected. © The Author(s) 2014.

  13. Injectable loop recorder implantation in an ambulatory setting by advanced practice providers: Analysis of outcomes.

    Science.gov (United States)

    Kipp, Ryan; Young, Natasha; Barnett, Anne; Kopp, Douglas; Leal, Miguel A; Eckhardt, Lee L; Teelin, Thomas; Hoffmayer, Kurt S; Wright, Jennifer; Field, Michael

    2017-09-01

    Implantable loop recorder (ILR) insertion has historically been performed in a surgical environment such as the electrophysiology (EP) lab. The newest generation loop recorder (Medtronic Reveal LINQ™, Minneapolis, MN, USA) is injectable with potential for implantation in a non-EP lab setting by advanced practice providers (APPs) facilitating improved workflow and resource utilization. We report the safety and efficacy of injectable ILR placement in the ambulatory care setting by APPs. A retrospective review was performed including all patients referred for injectable ILR placement from March 2014 to November 2015. All device placement procedures were performed in an ambulatory care setting using the standard manufacturer deployment kit with sterile technique and local anesthetic following a single dose of intravenous antibiotics. Acute procedural success and complication rates following injectable ILR placement in the ambulatory setting were reviewed. During the study period, 125 injectable ILRs were implanted. Acute procedural success with adequate sensing (R-waves ≥ 0.2 mV) occurred in 100% of patients. There were no acute procedural complications. Subacute complications occurred in two patients (1.6% of implantations), including one possible infection treated with oral antibiotics and one device removal due to pain at the implant site. In this retrospective single-center study, implantation of injectable ILR in an ambulatory care setting by APPs following a single dose of intravenous antibiotics and standard manufacturer technique yielded a low complication rate with high acute procedural success. Use of this implantation strategy may improve EP lab workflow while providing a safe and effective technique for device placement. © 2017 Wiley Periodicals, Inc.

  14. Integrated model for providing tactical emergency medicine support (TEMS): analysis of 120 tactical situations.

    Science.gov (United States)

    Vainionpää, T; Peräjoki, K; Hiltunen, T; Porthan, K; Taskinen, A; Boyd, J; Kuisma, M

    2012-02-01

    Various models for organising tactical emergency medicine support (TEMS) in law enforcement operations exist. In Helsinki, TEMS is organised as an integral part of emergency medical service (EMS) and applied in hostage, siege, bomb threat and crowd control situations and in other tactical situations after police request. Our aim was to analyse TEMS operations, patient profile, and the level of on-site care provided. We conducted a retrospective cohort study of TEMS operations in Helsinki from 2004 to 2009. Data were retrieved from EMS, hospital and dispatching centre files and from TEMS reports. One hundred twenty TEMS operations were analysed. Median time from dispatching to arrival on scene was 10 min [Interquartile Range (IQR) 7-14]. Median duration of operations was 41 min (IQR 19-63). Standby was the only activity in 72 operations, four patients were dead on arrival, 16 requests were called off en route and patient examination or care was needed in 28 operations. Twenty-eight patients (records retrieved) were alive on arrival and were classified as trauma (n = 12) or medical (n = 16). Of traumas, two sustained a gunshot wound, one sustained a penetrating abdominal wound, three sustained medium severity injuries and nine sustained minor injuries. There was neither on-scene nor in-hospital mortality among patients who were alive on arrival. The level of on-site care performed was basic life support in all cases. The results showed that TEMS integrated to daily EMS services including safe zone working only was a feasible, rapid and efficient way to provide medical support to law enforcement operations. © 2011 The Authors Acta Anaesthesiologica Scandinavica © 2011 The Acta Anaesthesiologica Scandinavica Foundation.

  15. Exploring Context and the Factors Shaping Team-Based Primary Healthcare Policies in Three Canadian Provinces: A Comparative Analysis.

    Science.gov (United States)

    Misfeldt, Renée; Suter, Esther; Mallinson, Sara; Boakye, Omenaa; Wong, Sabrina; Nasmith, Louise

    2017-08-01

    This paper discusses findings from a high-level scan of the contextual factors and actors that influenced policies on team-based primary healthcare in three Canadian provinces: British Columbia, Alberta and Saskatchewan. The team searched diverse sources (e.g., news reports, press releases, discussion papers) for contextual information relevant to primary healthcare teams. We also conducted qualitative interviews with key health system informants from the three provinces. Data from documents and interviews were analyzed qualitatively using thematic analysis. We then wrote narrative summaries highlighting pivotal policy and local system events and the influence of actors and context. Our overall findings highlight the value of reviewing the context, relationships and power dynamics, which come together and create "policy windows" at different points in time. We observed physician-centric policy processes with some recent moves to rebalance power and be inclusive of other actors and perspectives. The context review also highlighted the significant influence of changes in political leadership and prioritization in driving policies on team-based care. While this existed in different degrees in the three provinces, the push and pull of political and professional power dynamics shaped Canadian provincial policies governing team-based care. If we are to move team-based primary healthcare forward in Canada, the provinces need to review the external factors and the complex set of relationships and trade-offs that underscore the policy process. Copyright © 2017 Longwoods Publishing.

  16. Mendelian randomisation analysis provides no evidence for a relationship between adult height and testicular cancer risk.

    Science.gov (United States)

    Levy, M; Hall, D; Sud, A; Law, P; Litchfield, K; Dudakia, D; Haugen, T B; Karlsson, R; Reid, A; Huddart, R A; Grotmol, T; Wiklund, F; Houlston, R S; Turnbull, C

    2017-09-01

    Observational studies have suggested anthropometric traits, particularly increased height are associated with an elevated risk of testicular cancer (testicular germ cell tumour). However, there is an inconsistency between study findings, suggesting the possibility of the influence of confounding factors. To examine the association between anthropometric traits and testicular germ cell tumour using an unbiased approach, we performed a Mendelian randomisation study. We used genotype data from genome wide association studies of testicular germ cell tumour totalling 5518 cases and 19,055 controls. Externally weighted polygenic risk scores were created and used to evaluate associations with testicular germ cell tumour risk per one standard deviation (s.d) increase in genetically-defined adult height, adult BMI, adult waist hip ratio adjusted for BMI (WHRadjBMI), adult hip circumference adjusted for BMI (HIPadjBMI), adult waist circumference adjusted for BMI (WCadjBMI), birth weight (BW) and childhood obesity. Mendelian randomisation analysis did not demonstrate an association between any anthropometric trait and testicular germ cell tumour risk. In particular, despite good power, there was no global evidence for association between height and testicular germ cell tumour. However, three SNPs for adult height individually showed association with testicular germ cell tumour (rs4624820: OR = 1.47, 95% CI: 1.41-1.55, p = 2.7 × 10 -57 ; rs12228415: OR = 1.17, 95% CI: 1.11-1.22, p = 3.1 × 10 -10 ; rs7568069: OR = 1.13, 95% CI: 1.07-1.18, p = 1.1 × 10 -6 ). This Mendelian randomisation analysis, based on the largest testicular germ cell tumour genome wide association dataset to date, does not support a causal etiological association between anthropometric traits and testicular germ cell tumour aetiology. Our findings are more compatible with confounding by shared environmental factors, possibly related to prenatal growth with exposure to these risk factors

  17. Ecosystem Services Provided by Agricultural Land as Modeled by Broad Scale Geospatial Analysis

    Science.gov (United States)

    Kokkinidis, Ioannis

    Agricultural ecosystems provide multiple services including food and fiber provision, nutrient cycling, soil retention and water regulation. Objectives of the study were to identify and quantify a selection of ecosystem services provided by agricultural land, using existing geospatial tools and preferably free and open source data, such as the Virginia Land Use Evaluation System (VALUES), the North Carolina Realistic Yield Expectations (RYE) database, and the land cover datasets NLCD and CDL. Furthermore I sought to model tradeoffs between provisioning and other services. First I assessed the accuracy of agricultural land in NLCD and CDL over a four county area in eastern Virginia using cadastral parcels. I uncovered issues concerning the definition of agricultural land. The area and location of agriculture saw little change in the 19 years studied. Furthermore all datasets have significant errors of omission (11.3 to 95.1%) and commission (0 to 71.3%). Location of agriculture was used with spatial crop yield databases I created and combined with models I adapted to calculate baseline values for plant biomass, nutrient composition and requirements, land suitability for and potential production of biofuels and the economic impact of agriculture for the four counties. The study area was then broadened to cover 97 counties in eastern Virginia and North Carolina, investigating the potential for increased regional grain production through intensification and extensification of agriculture. Predicted yield from geospatial crop models was compared with produced yield from the NASS Survey of Agriculture. Area of most crops in CDL was similar to that in the Survey of Agriculture, but a yield gap is present for most years, partially due to weather, thus indicating potential for yield increase through intensification. Using simple criteria I quantified the potential to extend agriculture in high yield land in other uses and modeled the changes in erosion and runoff should

  18. ANALYSIS OF THE ENERGY SYSTEM BALANCE EFFICIENCY PROVIDED WITH THE DIFFERENT GROUPS OF GENERATING PLANTS

    Directory of Open Access Journals (Sweden)

    O. Maksymovа

    2017-12-01

    Full Text Available Currently methods of efficiency analysis are being developed and applied, based on optimization tasks for various types and modes. Usually, the optimization criterion for these objectives is efficiency that can be calculated in various ways, for which there is no concurrent views. The target function based on minimization of given cost that allows comparing options with the same useful effect is used to search for the best indicators of power plants operated within the system. Marginal costs on the amount of difference in the useful effect are introduced to the target function in case of various useful effects. The criterion of selecting the best power plant from an economic point of view is the difference between the reduced costs of the considered and the basic options, but this approach does not allow using the results for long-term projections. Such approach depends on the situation and does not reflect the real costs. The value of the target function to optimize the effectiveness of the technical-economic method is not "marginal" and does not allow assessing the impact of various processes on the overall option efficiency. Therefore, the development of the efficiency criterion that considers the changing needs of the energy system is relevant for analyzing the power plant.

  19. Online genetic counseling from the providers' perspective: counselors' evaluations and a time and cost analysis

    Science.gov (United States)

    Otten, Ellen; Birnie, Erwin; Ranchor, Adelita V; van Langen, Irene M

    2016-01-01

    Telemedicine applications are increasingly being introduced in patient care in various disciplines, including clinical genetics, mainly to increase access to care and to reduce time and costs for patients and professionals. Most telegenetics reports describe applications in large geographical areas, showing positive patients' and professionals' satisfaction. One economic analysis published thus far reported lower costs than in-person care. We hypothesized that telegenetics can also be beneficial from the professional's view in relatively small geographical areas. We performed a pilot study in the Northern Netherlands of 51 home-based online counseling sessions for cardiogenetic and oncogenetic cascade screening, and urgent prenatal counseling. Previously, we showed patient satisfaction, anxiety, and perceived control of online counseling to be comparable to in-person counseling. This study focuses on expectations, satisfaction, and practical evaluations of the involved counselors, and the impact in terms of time and costs. Most counselors expected disadvantages of online counseling for themselves and their patients, mainly concerning insufficient non-verbal communication; few expected advantages for themselves. Afterwards, counselors additionally raised the disadvantage of insufficient verbal communication, and reported frequent technical problems. Their overall mean telemedicine satisfaction itemscore was 3.38 before, and 2.95 afterwards, being afterwards slightly below the minimum level we set for a satisfactory result. We estimated reduced time and costs by online counseling with about 8% and 10–12%, respectively. We showed online genetic counseling to be effective, feasible and cost-efficient, but technical improvements are needed to increase counselors' satisfaction. PMID:26785833

  20. Citation analysis did not provide a reliable assessment of core outcome set uptake.

    Science.gov (United States)

    Barnes, Karen L; Kirkham, Jamie J; Clarke, Mike; Williamson, Paula R

    2017-06-01

    The aim of the study was to evaluate citation analysis as an approach to measuring core outcome set (COS) uptake, by assessing whether the number of citations for a COS report could be used as a surrogate measure of uptake of the COS by clinical trialists. Citation data were obtained for COS reports published before 2010 in five disease areas (systemic sclerosis, rheumatoid arthritis, eczema, sepsis and critical care, and female sexual dysfunction). Those publications identified as a report of a clinical trial were examined to identify whether or not all outcomes in the COS were measured in the trial. Clinical trials measuring the relevant COS made up a small proportion of the total number of citations for COS reports. Not all trials citing a COS report measured all the recommended outcomes. Some trials cited the COS reports for other reasons, including the definition of a condition or other trial design issues addressed by the COS report. Although citation data can be readily accessed, it should not be assumed that the citing of a COS report indicates that a trial has measured the recommended COS. Alternative methods for assessing COS uptake are needed. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  1. Comparative Analysis of Two Flavonol Synthases from Different-Colored Onions Provides Insight into Flavonoid Biosynthesis.

    Science.gov (United States)

    Park, Sangkyu; Kim, Da-Hye; Lee, Jong-Yeol; Ha, Sun-Hwa; Lim, Sun-Hyung

    2017-07-05

    We isolated cDNAs encoding flavonol synthase (FLS) from the red onion "H6" (AcFLS-H6) and the yellow onion "Hwangryongball" (AcFLS-HRB). We found three amino acid variations between the two sequences. Kinetic analysis with recombinant proteins revealed that AcFLS-HRB exhibited approximately 2-fold higher catalytic efficiencies than AcFLS-H6 for dihydroflavonol substrates and that both proteins preferred dihydroquercetin to dihydrokaempferol. The expression patterns of flavonoid biosynthesis genes corresponded to the accumulation patterns of flavonoid aglycones in both onions. Whereas the other flavonoid biosynthesis genes were weakly expressed in the HRB sheath compared to that of H6, the expression of FLS was similar in both onions. This relatively enhanced FLS expression, along with the higher activity of AcFLS-HRB, could increase the quercetin production in the HRB sheath. The quercetin content was approximately 12-fold higher than the cyanidin content in the H6 sheath, suggesting that FLS has priority in the competition between FLS and dihydroflavonol 4-reductase (DFR) for their substrate dihydroquercetin.

  2. Analysis of horse genomes provides insight into the diversification and adaptive evolution of karyotype.

    Science.gov (United States)

    Huang, Jinlong; Zhao, Yiping; Shiraigol, Wunierfu; Li, Bei; Bai, Dongyi; Ye, Weixing; Daidiikhuu, Dorjsuren; Yang, Lihua; Jin, Burenqiqige; Zhao, Qinan; Gao, Yahan; Wu, Jing; Bao, Wuyundalai; Li, Anaer; Zhang, Yuhong; Han, Haige; Bai, Haitang; Bao, Yanqing; Zhao, Lele; Zhai, Zhengxiao; Zhao, Wenjing; Sun, Zikui; Zhang, Yan; Meng, He; Dugarjaviin, Manglai

    2014-05-14

    Karyotypic diversification is more prominent in Equus species than in other mammals. Here, using next generation sequencing technology, we generated and de novo assembled quality genomes sequences for a male wild horse (Przewalski's horse) and a male domestic horse (Mongolian horse), with about 93-fold and 91-fold coverage, respectively. Portion of Y chromosome from wild horse assemblies (3 M bp) and Mongolian horse (2 M bp) were also sequenced and de novo assembled. We confirmed a Robertsonian translocation event through the wild horse's chromosomes 23 and 24, which contained sequences that were highly homologous with those on the domestic horse's chromosome 5. The four main types of rearrangement, insertion of unknown origin, inserted duplication, inversion, and relocation, are not evenly distributed on all the chromosomes, and some chromosomes, such as the X chromosome, contain more rearrangements than others, and the number of inversions is far less than the number of insertions and relocations in the horse genome. Furthermore, we discovered the percentages of LINE_L1 and LTR_ERV1 are significantly increased in rearrangement regions. The analysis results of the two representative Equus species genomes improved our knowledge of Equus chromosome rearrangement and karyotype evolution.

  3. Metatranscriptome Analysis of Fig Flowers Provides Insights into Potential Mechanisms for Mutualism Stability and Gall Induction.

    Directory of Open Access Journals (Sweden)

    Ellen O Martinson

    Full Text Available A striking property of the mutualism between figs and their pollinating wasps is that wasps consistently oviposit in the inner flowers of the fig syconium, which develop into galls that house developing larvae. Wasps typically do not use the outer ring of flowers, which develop into seeds. To better understand differences between gall and seed flowers, we used a metatranscriptomic approach to analyze eukaryotic gene expression within fig flowers at the time of oviposition choice and early gall development. Consistent with the unbeatable seed hypothesis, we found significant differences in gene expression between gall- and seed flowers in receptive syconia prior to oviposition. In particular, transcripts assigned to flavonoids and carbohydrate metabolism were significantly up-regulated in gall flowers relative to seed flowers. In response to oviposition, gall flowers significantly up-regulated the expression of chalcone synthase, which previously has been connected to gall formation in other plants. We propose several genes encoding proteins with signal peptides or associations with venom of other Hymenoptera as candidate genes for gall initiation or growth. This study simultaneously evaluates the gene expression profile of both mutualistic partners in a plant-insect mutualism and provides insight into a possible stability mechanism in the ancient fig-fig wasp association.

  4. In vitro analysis of RQC activities provides insights into the mechanism and function of CAT tailing

    Science.gov (United States)

    Osuna, Beatriz A; Howard, Conor J; KC, Subheksha; Frost, Adam; Weinberg, David E

    2017-01-01

    Ribosomes can stall during translation due to defects in the mRNA template or translation machinery, leading to the production of incomplete proteins. The Ribosome-associated Quality control Complex (RQC) engages stalled ribosomes and targets nascent polypeptides for proteasomal degradation. However, how each RQC component contributes to this process remains unclear. Here we demonstrate that key RQC activities—Ltn1p-dependent ubiquitination and Rqc2p-mediated Carboxy-terminal Alanine and Threonine (CAT) tail elongation—can be recapitulated in vitro with a yeast cell-free system. Using this approach, we determined that CAT tailing is mechanistically distinct from canonical translation, that Ltn1p-mediated ubiquitination depends on the poorly characterized RQC component Rqc1p, and that the process of CAT tailing enables robust ubiquitination of the nascent polypeptide. These findings establish a novel system to study the RQC and provide a framework for understanding how RQC factors coordinate their activities to facilitate clearance of incompletely synthesized proteins. DOI: http://dx.doi.org/10.7554/eLife.27949.001 PMID:28718767

  5. Genome-wide analysis of ionotropic receptors provides insight into their evolution in Heliconius butterflies.

    Science.gov (United States)

    van Schooten, Bas; Jiggins, Chris D; Briscoe, Adriana D; Papa, Riccardo

    2016-03-22

    In a world of chemical cues, smell and taste are essential senses for survival. Here we focused on Heliconius, a diverse group of butterflies that exhibit variation in pre- and post-zygotic isolation and chemically-mediated behaviors across their phylogeny. Our study examined the ionotropic receptors, a recently discovered class of receptors that are some of the most ancient chemical receptors. We found more ionotropic receptors in Heliconius (31) than in Bombyx mori (25) or in Danaus plexippus (27). Sixteen genes in Lepidoptera were not present in Diptera. Only IR7d4 was exclusively found in butterflies and two expansions of IR60a were exclusive to Heliconius. A genome-wide comparison between 11 Heliconius species revealed instances of pseudogenization, gene gain, and signatures of positive selection across the phylogeny. IR60a2b and IR60a2d are unique to the H. melpomene, H. cydno, and H. timareta clade, a group where chemosensing is likely involved in pre-zygotic isolation. IR60a2b also displayed copy number variations (CNVs) in distinct populations of H. melpomene and was the only gene significantly higher expressed in legs and mouthparts than in antennae, which suggests a gustatory function. dN/dS analysis suggests more frequent positive selection in some intronless IR genes and in particular in the sara/sapho and melpomene/cydno/timareta clades. IR60a1 was the only gene with an elevated dN/dS along a major phylogenetic branch associated with pupal mating. Only IR93a was differentially expressed between sexes. All together these data make Heliconius butterflies one of the very few insects outside Drosophila where IRs have been characterized in detail. Our work outlines a dynamic pattern of IR gene evolution throughout the Heliconius radiation which could be the result of selective pressure to find potential mates or host-plants.

  6. Comparative EST analysis provides insights into the basal aquatic fungus Blastocladiella emersonii

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    Gomes Suely L

    2006-07-01

    Full Text Available Abstract Background Blastocladiella emersonii is an aquatic fungus of the Chytridiomycete class, which is at the base of the fungal phylogenetic tree. In this sense, some ancestral characteristics of fungi and animals or fungi and plants could have been retained in this aquatic fungus and lost in members of late-diverging fungal species. To identify in B. emersonii sequences associated with these ancestral characteristics two approaches were followed: (1 a large-scale comparative analysis between putative unigene sequences (uniseqs from B. emersonii and three databases constructed ad hoc with fungal proteins, animal proteins and plant unigenes deposited in Genbank, and (2 a pairwise comparison between B. emersonii full-length cDNA sequences and their putative orthologues in the ascomycete Neurospora crassa and the basidiomycete Ustilago maydis. Results Comparative analyses of B. emersonii uniseqs with fungi, animal and plant databases through the two approaches mentioned above produced 166 B. emersonii sequences, which were identified as putatively absent from other fungi or not previously described. Through these approaches we found: (1 possible orthologues of genes previously identified as specific to animals and/or plants, and (2 genes conserved in fungi, but with a large difference in divergence rate in B. emersonii. Among these sequences, we observed cDNAs encoding enzymes from coenzyme B12-dependent propionyl-CoA pathway, a metabolic route not previously described in fungi, and validated their expression in Northern blots. Conclusion Using two different approaches involving comparative sequence analyses, we could identify sequences from the early-diverging fungus B. emersonii previously considered specific to animals or plants, and highly divergent sequences from the same fungus relative to other fungi.

  7. Comparison of automatic procedures in the selection of peaks over threshold in flood frequency analysis: A Canadian case study in the context of climate change

    Science.gov (United States)

    Durocher, M.; Mostofi Zadeh, S.; Burn, D. H.; Ashkar, F.

    2017-12-01

    Floods are one of the most costly hazards and frequency analysis of river discharges is an important part of the tools at our disposal to evaluate their inherent risks and to provide an adequate response. In comparison to the common examination of annual streamflow maximums, peaks over threshold (POT) is an interesting alternative that makes better use of the available information by including more than one flood event per year (on average). However, a major challenge is the selection of a satisfactory threshold above which peaks are assumed to respect certain conditions necessary for an adequate estimation of the risk. Additionally, studies have shown that POT is also a valuable approach to investigate the evolution of flood regimes in the context of climate change. Recently, automatic procedures for the selection of the threshold were suggested to guide that important choice, which otherwise rely on graphical tools and expert judgment. Furthermore, having an automatic procedure that is objective allows for quickly repeating the analysis on a large number of samples, which is useful in the context of large databases or for uncertainty analysis based on a resampling approach. This study investigates the impact of considering such procedures in a case study including many sites across Canada. A simulation study is conducted to evaluate the bias and predictive power of the automatic procedures in similar conditions as well as investigating the power of derived nonstationarity tests. The results obtained are also evaluated in the light of expert judgments established in a previous study. Ultimately, this study provides a thorough examination of the considerations that need to be addressed when conducting POT analysis using automatic threshold selection.

  8. Techno-Economic Analysis of BEV Service Providers Offering Battery Swapping Services

    Energy Technology Data Exchange (ETDEWEB)

    Neubauer, J. S.; Pesaran, A.

    2013-01-01

    Battery electric vehicles (BEVs) offer the potential to reduce both oil imports and greenhouse gas emissions, but high upfront costs, battery-limited vehicle range, and concern over high battery replacement costs may discourage potential buyers. A subscription model in which a service provider owns the battery and supplies access to battery swapping infrastructure could reduce upfront and replacement costs for batteries with a predictable monthly fee, while expanding BEV range. Assessing the costs and benefits of such a proposal are complicated by many factors, including customer drive patterns, the amount of required infrastructure, battery life, etc. The National Renewable Energy Laboratory has applied its Battery Ownership Model to compare the economics and utility of BEV battery swapping service plan options to more traditional direct ownership options. Our evaluation process followed four steps: (1) identifying drive patterns best suited to battery swapping service plans, (2) modeling service usage statistics for the selected drive patterns, (3) calculating the cost-of-service plan options, and (4) evaluating the economics of individual drivers under realistically priced service plans. A service plan option can be more cost-effective than direct ownership for drivers who wish to operate a BEV as their primary vehicle where alternative options for travel beyond the single-charge range are expensive, and a full-coverage-yet-cost-effective regional infrastructure network can be deployed. However, when assumed cost of gasoline, tax structure, and absence of purchase incentives are factored in, our calculations show the service plan BEV is rarely more cost-effective than direct ownership of a conventional vehicle.

  9. Techno-Economic Analysis of BEV Service Providers Offering Battery Swapping Services: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Neubauer, J.; Pesaran, A.

    2013-03-01

    Battery electric vehicles (BEVs) offer the potential to reduce both oil imports and greenhouse gas emissions, but high upfront costs, battery-limited vehicle range, and concern over high battery replacement costs may discourage potential buyers. A subscription model in which a service provider owns the battery and supplies access to battery swapping infrastructure could reduce upfront and replacement costs for batteries with a predictable monthly fee, while expanding BEV range. Assessing the costs and benefits of such a proposal are complicated by many factors, including customer drive patterns, the amount of required infrastructure, battery life, etc. The National Renewable Energy Laboratory has applied its Battery Ownership Model to compare the economics and utility of BEV battery swapping service plan options to more traditional direct ownership options. Our evaluation process followed four steps: (1) identifying drive patterns best suited to battery swapping service plans, (2) modeling service usage statistics for the selected drive patterns, (3) calculating the cost-of-service plan options, and (4) evaluating the economics of individual drivers under realistically priced service plans. A service plan option can be more cost-effective than direct ownership for drivers who wish to operate a BEV as their primary vehicle where alternative options for travel beyond the single-charge range are expensive, and a full-coverage-yet-cost-effective regional infrastructure network can be deployed. However, when assumed cost of gasoline, tax structure, and absence of purchase incentives are factored in, our calculations show the service plan BEV is rarely more cost-effective than direct ownership of a conventional vehicle.

  10. Transcriptome analysis of Crossostephium chinensis provides insight into the molecular basis of salinity stress responses.

    Directory of Open Access Journals (Sweden)

    Haiyan Yang

    Full Text Available Soil salinization is becoming a limitation to the utilization of ornamental plants worldwide. Crossostephium chinensis (Linnaeus Makino is often cultivated along the southeast coast of China for its desirable ornamental qualities and high salt tolerance. However, little is known about the genomic background of the salt tolerance mechanism in C. chinensis. In the present study, we used Illumina paired-end sequencing to systematically investigate leaf transcriptomes derived from C. chinensis seedlings grown under normal conditions and under salt stress. A total of 105,473,004 bp of reads were assembled into 163,046 unigenes, of which 65,839 (40.38% of the total and 54,342 (33.32% of the total were aligned in Swiss-Prot and Nr protein, respectively. A total of 11,331 (6.95% differentially expressed genes (DEGs were identified among three comparisons, including 2,239 in 'ST3 vs ST0', 5,880 in 'ST9 vs ST3' and 9,718 in 'ST9 vs ST0', and they were generally classified into 26 Gene Ontology terms and 58 Kyoto Encyclopedia of Genes and Genomes (KEGG pathway terms. Many genes encoding important transcription factors (e.g., WRKY, MYB, and AP2/EREBP and proteins involved in starch and sucrose metabolism, arginine and proline metabolism, plant hormone signal transduction, amino acid biosynthesis, plant-pathogen interactions and carbohydrate metabolism, among others, were substantially up-regulated under salt stress. These genes represent important candidates for studying the salt-response mechanism and molecular biology of C. chinensis and its relatives. Our findings provide a genomic sequence resource for functional genetic assignments in C. chinensis. These transcriptome datasets will help elucidate the molecular mechanisms responsible for salt-stress tolerance in C. chinensis and facilitate the breeding of new stress-tolerant cultivars for high-saline areas using this valuable genetic resource.

  11. Proteomic analysis of FUS interacting proteins provides insights into FUS function and its role in ALS.

    Science.gov (United States)

    Kamelgarn, Marisa; Chen, Jing; Kuang, Lisha; Arenas, Alexandra; Zhai, Jianjun; Zhu, Haining; Gal, Jozsef

    2016-10-01

    Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease. Mutations in the Fused in Sarcoma/Translocated in Liposarcoma (FUS/TLS) gene cause a subset of familial ALS cases and are also implicated in sporadic ALS. FUS is typically localized to the nucleus. The ALS-related FUS mutations cause cytoplasmic mis-localization and the formation of stress granule-like structures. Abnormal cytoplasmic FUS localization was also found in a subset of frontotemporal dementia (FTLD) cases without FUS mutations. To better understand the function of FUS, we performed wild-type and mutant FUS pull-downs followed by proteomic identification of the interacting proteins. The FUS interacting partners we identified are involved in multiple pathways, including chromosomal organization, transcription, RNA splicing, RNA transport, localized translation, and stress response. FUS interacted with hnRNPA1 and Matrin-3, RNA binding proteins whose mutations were also reported to cause familial ALS, suggesting that hnRNPA1 and Matrin-3 may play common pathogenic roles with FUS. The FUS interactions displayed varied RNA dependence. Numerous FUS interacting partners that we identified are components of exosomes. We found that FUS itself was present in exosomes, suggesting that the secretion of FUS might contribute to the cell-to-cell spreading of FUS pathology. FUS interacting proteins were sequestered into the cytoplasmic mutant FUS inclusions that could lead to their mis-regulation or loss of function, contributing to ALS pathogenesis. Our results provide insights into the physiological functions of FUS as well as important pathways where mutant FUS can interfere with cellular processes and potentially contribute to the pathogenesis of ALS. Copyright © 2016 Elsevier B.V. All rights reserved.

  12. Comprehensive transcriptome analysis provides new insights into nutritional strategies and phylogenetic relationships of chrysophytes

    Directory of Open Access Journals (Sweden)

    Daniela Beisser

    2017-01-01

    based on ribosomal RNA and orthologous genes. Finally, we make functionally annotated reference transcriptomes of each strain available to the community, significantly enhancing publicly available data on Chrysophyceae. Conclusions Our study is the first comprehensive transcriptomic characterisation of a diverse set of Chrysophyceaen strains. In addition, we showcase the possibility of inferring phylogenies from assembled transcriptomes using an alignment-free approach. The raw and functionally annotated data we provide will prove beneficial for further examination of the diversity within this taxon. Our molecular characterisation of different trophic modes presents a first such example.

  13. Bullying prevalence across contexts: a meta-analysis measuring cyber and traditional bullying.

    Science.gov (United States)

    Modecki, Kathryn L; Minchin, Jeannie; Harbaugh, Allen G; Guerra, Nancy G; Runions, Kevin C

    2014-11-01

    Bullying involvement in any form can have lasting physical and emotional consequences for adolescents. For programs and policies to best safeguard youth, it is important to understand prevalence of bullying across cyber and traditional contexts. We conducted a thorough review of the literature and identified 80 studies that reported corresponding prevalence rates for cyber and traditional bullying and/or aggression in adolescents. Weighted mean effect sizes were calculated, and measurement features were entered as moderators to explain variation in prevalence rates and in traditional-cyber correlations within the sample of studies. Prevalence rates for cyber bullying were lower than for traditional bullying, and cyber and traditional bullying were highly correlated. A number of measurement features moderated variability in bullying prevalence; whereas a focus on traditional relational aggression increased correlations between cyber and traditional aggressions. In our meta-analytic review, traditional bullying was twice as common as cyber bullying. Cyber and traditional bullying were also highly correlated, suggesting that polyaggression involvement should be a primary target for interventions and policy. Results of moderation analyses highlight the need for greater consensus in measurement approaches for both cyber and traditional bullying. Copyright © 2014 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

  14. A dyadic analysis of relationships and health: does couple-level context condition partner effects?

    Science.gov (United States)

    Barr, Ashley B; Simons, Ronald L

    2014-08-01

    Adding to the growing literature explicating the links between romantic relationships and health, this study examined how both couple-level characteristics, particularly union type (e.g., dating, cohabiting, or marriage) and interracial pairing, and interpersonal characteristics (e.g., partner strain and support), predicted young adults' physical and mental health. Using dyadic data from a sample of 249 young, primarily Black couples, we hypothesized and found support for the importance of couple-level context, partner behavior, and their interaction in predicting health. Interracial couples (all Black/non-Black pairings) reported worse health than monoracial Black couples. Union type, however, did not directly predict health but was a significant moderator of partner strain. That is, the negative association between partner strain and self-reported health was stronger for cohabiting and married couples versus their dating counterparts, suggesting that coresidence, more so than marital status, may be important for understanding partner effects on physical health. For psychological distress, however, partner support proved equally beneficial across union types.

  15. Scientific Production on Open Access: A Worldwide Bibliometric Analysis in the Academic and Scientific Context

    Directory of Open Access Journals (Sweden)

    Sandra Miguel

    2016-01-01

    Full Text Available This research aims to diachronically analyze the worldwide scientific production on open access, in the academic and scientific context, in order to contribute to knowledge and visualization of its main actors. As a method, bibliographical, descriptive and analytical research was used, with the contribution of bibliometric studies, especially the production indicators, scientific collaboration and indicators of thematic co-occurrence. The Scopus database was used as a source to retrieve the articles on the subject, with a resulting corpus of 1179 articles. Using Bibexcel software, frequency tables were constructed for the variables, and Pajek software was used to visualize the collaboration network and VoSViewer for the construction of the keywords’ network. As for the results, the most productive researchers come from countries such as the United States, Canada, France and Spain. Journals with higher impact in the academic community have disseminated the new constructed knowledge. A collaborative network with a few subnets where co-authors are from different countries has been observed. As conclusions, this study allows identifying the themes of debates that mark the development of open access at the international level, and it is possible to state that open access is one of the new emerging and frontier fields of library and information science.

  16. Analysis of Purchasing Power Parities in Romania in the context of EU integration

    Directory of Open Access Journals (Sweden)

    Roxana Cristina Vîlcu

    2015-03-01

    Full Text Available Purchasing power parity (PPP is a useful tool for international comparison of prices between countries, in order to analyze the degree of economic development. On this line, purchasing power parities are indicators that express the main macroeconomic aggregates, in a common currency for all the countries subject to international comparisons. This material analyzes the evolution of PPP in Romania for a time interval of 10 years (2004-2013. The purpose of research is to analyze the purchasing power at national level, in the context of integration in European Union (EU. The period before and after Romania’s integration in the EU, has an important role to establish the positioning of our country in terms of purchasing power, compared to the other EU countries. The main conclusion of the paper is that Romania is the country with one of the lowest purchasing power parities compared to other EU countries, along with Bulgaria, which joined the EU in the same year (2007. Given that PPP cannot establish a hierarchy of countries, the research takes into account other important indicators such as: Harmonised Indices of Consumer Prices, GDP and inflation rate.

  17. A Dyadic Analysis of Relationships and Health: Does Couple-Level Context Condition Partner Effects?

    Science.gov (United States)

    Barr, Ashley B.; Simons, Ronald L.

    2014-01-01

    Adding to the growing literature explicating the links between romantic relationships and health, this study examined how both couple-level characteristics, particularly union type (e.g. dating, cohabiting, or marriage) and interracial pairing, and interpersonal characteristics (e.g. partner strain and support) predicted young adults’ physical and mental health. Using dyadic data from a sample of 249 young, primarily African American couples, we hypothesized and found support for the importance of couple-level context, partner behavior, and their interaction in predicting health. Interracial couples (all Black/non-Black pairings) reported worse health than monoracial Black couples. Union type, however, did not directly predict health but was a significant moderator of partner strain. That is, the negative association between partner strain and self-reported health was stronger for cohabiting and married couples versus their dating counterparts, suggesting that coresidence more so than marital status may be important for understanding partner effects on physical health. For psychological distress, however, partner support proved equally beneficial across union types. PMID:25090254

  18. Numerical analysis of single particle impact in the context of Cold Spray: a new adhesion model

    Science.gov (United States)

    Profizi, P.; Combescure, A.; Ogawa, K.

    2016-03-01

    A new adhesion model for numerical simulation of single particle impact in the context of Cold Spray is introduced. As in other studies, cohesive forces are put between the particle and substrate to account for adhesion. In this study however, the forces are put only when a local physical criterion is met. The physical phenomenon most often attributed to Cold Spray adhesion is a shear stress instability. The Johnson-Cook material law is used with a shear damage softening law to enable strong localization at the interface without the need for an extremely fine mesh. This localization is then detected as a drop in local yield stress value by the algorithm, which then implements a local cohesive force. The evolution of this cohesive force is defined by an energy dissipative cohesive model, using a surface adhesion energy as a material parameter. Each cohesive link is broken once all its associated surface energy is dissipated. A criterion on the damage value is also used to break a cohesive bond prematurely, to account for the effect of erosion at higher speeds. This model is found to reproduce the Cold Spray-like adhesion behavior with observed critical and maximum speeds.

  19. Oxygen distribution in tumors: A qualitative analysis and modeling study providing a novel Monte Carlo approach

    International Nuclear Information System (INIS)

    Lagerlöf, Jakob H.; Kindblom, Jon; Bernhardt, Peter

    2014-01-01

    end, due to anoxia, but smaller tumors showed undisturbed oxygen distributions. The six different models with correlated parameters generated three classes of oxygen distributions. The first was a hypothetical, negative covariance between vessel proximity and pO 2 (VPO-C scenario); the second was a hypothetical positive covariance between vessel proximity and pO 2 (VPO+C scenario); and the third was the hypothesis of no correlation between vessel proximity and pO 2 (UP scenario). The VPO-C scenario produced a distinctly different oxygen distribution than the two other scenarios. The shape of the VPO-C scenario was similar to that of the nonvariable DOC model, and the larger the tumor, the greater the similarity between the two models. For all simulations, the mean oxygen tension decreased and the hypoxic fraction increased with tumor size. The absorbed dose required for definitive tumor control was highest for the VPO+C scenario, followed by the UP and VPO-C scenarios. Conclusions: A novel MC algorithm was presented which simulated oxygen distributions and radiation response for various biological parameter values. The analysis showed that the VPO-C scenario generated a clearly different oxygen distribution from the VPO+C scenario; the former exhibited a lower hypoxic fraction and higher radiosensitivity. In future studies, this modeling approach might be valuable for qualitative analyses of factors that affect oxygen distribution as well as analyses of specific experimental and clinical situations

  20. Insights to Meteorites and Impact Processes provided by Advanced EBSD Analysis

    Science.gov (United States)

    Palasse, Laurie; Berlin, Jana; Goran, Daniel; Tagle, Roald; Hamers, Maartje; Assis Fernandes, Vera; Deutsch, Alexander; Schulte, Peter; Salge, Tobias

    2013-04-01

    . For Chicxulub, the brecciated impact melt rock from borehole Yaxcopoil-1 (Unit 5, 861.72 m) [3] reveals that the ballen microstructure is only semi-amorphous and cross cuts a fine grained recrystallised microstructure. (C) CB chondrite Gujba: EDS and EBSD data were acquired simultaneously to study chemical and physical interactions between preexisting metal particles and the invading silicate-rich impact melt matrix. Metal particles appear to have different thermal histories. Some of them consist of many small grains (average diameter ~10 µm), which have a similar orientation when they are surrounded by arcuate Fe,Cr-sulfides. [4]. Acknowledgements: P. Claeys, R.H. Jones, ICDP and the Museum of Natural History Berlin for providing samples. References: [1] T. Salge (2007) PhD thesis, Humboldt Universität zu Berlin, 130p. [2] A. P. Jones et al. (2000) Lect. Notes in Earth Sciences 91: 343-361. [3] M. J. Nelson et al. (2012) GCA 86: 1-20. [4]. J. Berlin et al. (2013) 44th LPSC # 2439

  1. Context of the care provided to a family member with bipolar disorder in Antioquia, Colombia = Las condiciones del cuidado en familias antioqueñas con un miembro con trastorno afectivo bipolar

    Directory of Open Access Journals (Sweden)

    Mauricio Hernando Bedoya Hernández

    2013-10-01

    Full Text Available This article is a report on the research “Care practices and family burden in families from Antioquia, Colombia, with a member diagnosed with bipolar affective disorder”. Objective: To recognize the context of the care provided to family members diagnosed with such disorder. Method: a qualitative study using the phenomenological and hermeneutic approach was done. Data were collected via in-depth interviews with the 12 families participating in the study, and a genogram was built. Results: two factors explain the increased stress and fatigue observed in family members taking care of a person with a mental condition: the first one is associated with the caregiver, and the second one, with the material and immaterial conditions of the care provided. Conclusions: (1 stress and fatigue are low when individuals willingly choose to take care of the person with a mental condition and thus define themselves as caregivers; (2 the quality and type of the bond established between the diseased person and the caregiver are strong predictors of family stress and fatigue; (3 this condition challenges the identity ofthe family and that of each one of its members.

  2. Economic Analysis: An Approach to Provide Basic Guidance for Conducting and Reviewing Economic Analysis within the Venezuelan Navy.

    Science.gov (United States)

    1986-06-01

    la Armada (EMGAR)-- Staff of the Navy ------------------------- 18 b. Direction de Presupuesto Programac ion Ecomica (DIPPE)-Direction of Budget and...Economic Programming -------------------- 18 c. Cornite De Programacion y Presupuesto (CPP)-- Programming and Budget Committee-----------18 3. Major...development. This analysis is included in the annual budget. b. Direction de Presupuesto Programaclon Ecomica (DIPPE)- Direction of Budget and Economic

  3. Caliper Context Annotation Library

    Energy Technology Data Exchange (ETDEWEB)

    2015-09-30

    To understand the performance of parallel programs, developers need to be able to relate performance measurement data with context information, such as the call path / line numbers or iteration numbers where measurements were taken. Caliper provides a generic way to specify and collect multi-dimensional context information across the software stack, and provide ti to third-party measurement tools or write it into a file or database in the form of context streams.

  4. Context-based object-of-interest detection for a generic traffic surveillance analysis system

    NARCIS (Netherlands)

    Bao, X.; Javanbakhti, S.; Zinger, S.; Wijnhoven, R.G.J.; With, de P.H.N.

    2014-01-01

    We present a new traffic surveillance video analysis system, focusing on building a framework with robust and generic techniques, based on both scene understanding and moving object-of-interest detection. Since traffic surveillance is widely applied, we want to design a single system that can be

  5. Codon usage vis-a-vis start and stop codon context analysis of three ...

    Indian Academy of Sciences (India)

    To understand the variation in genomic composition and its effect on codon usage, we performed the comparative analysis of codon usage and nucleotide usage in the genes of three dicots, Glycine max, Arabidopsis thaliana and Medicago truncatula. The dicot genes were found to be A/T rich and have predominantly ...

  6. Maternal Employment and Children's Achievement in Context: A Meta-Analysis of Four Decades of Research

    Science.gov (United States)

    Goldberg, Wendy A.; Prause, JoAnn; Lucas-Thompson, Rachel; Himsel, Amy

    2008-01-01

    This meta-analysis of 68 studies (770 effect sizes) used random effects models to examine whether children's achievement differed depending on whether their mothers were employed. Four achievement outcomes were emphasized: formal tests of achievement and intellectual functioning, grades, and teacher ratings of cognitive competence. When all…

  7. An Analysis of College Students' Attitudes towards Error Correction in EFL Context

    Science.gov (United States)

    Zhu, Honglin

    2010-01-01

    This article is based on a survey on the attitudes towards the error correction by their teachers in the process of teaching and learning and it is intended to improve the language teachers' understanding of the nature of error correction. Based on the analysis, the article expounds some principles and techniques that can be applied in the process…

  8. Schema-Based Analysis of Gendered Self-Disclosure in Persian: Writing for Dating Context

    Science.gov (United States)

    Khodadady, Ebrahim; Mehr, Somayeh Javadi

    2012-01-01

    This paper reports a textual analysis of letters written by 21 male and 21 female participants in Persian. Each writer wrote two letters, one to a dating service and another one to a hypothetical person chosen and introduced by the center. Therefore, a total of 84 letters were collected from the participants. Schema theory was used to find the…

  9. Community Mental Health Preparedness in Disasters: A Qualitative Content Analysis in an Iranian Context

    Directory of Open Access Journals (Sweden)

    Juliet Roudini

    2017-07-01

    Conclusion: Mental health preparedness is a multifactorial phenomenon that requires a clear understanding and definition of perceived threats, public trust on social structure and formal and informal supportive organization. This preparedness involves proportional, mental, social, familial, religious beliefs, and cultural sensitivity along with the ability to handle mentally disastrous situation, which can be measured after concept analysis and tool development process.

  10. Bringing in the Bard: Shakespearean Plays as Context for Instrumental Analysis Projects

    Science.gov (United States)

    Kloepper, Kathryn D.

    2015-01-01

    Scenes from the works of William Shakespeare were incorporated into individual and group projects for an upper-level chemistry class, instrumental analysis. Students read excerpts from different plays and then viewed a corresponding video clip from a stage or movie production. Guided-research assignments were developed based on these scenes. These…

  11. Insult in Context: Incorporating Speech Act Theory in Doctrinal Legal Analysis of Interpretative Discussions

    NARCIS (Netherlands)

    H.T.M. Kloosterhuis (Harm)

    2015-01-01

    textabstractIn this article, I want to show that some doctrinal problems of legal interpretation and argumentation can be analysed in a more precise way than a standard doctrinal analysis, when we use insights from speech act theory and argumentation theory. Taking a discussion about the accusation

  12. Girls' Doll Play in Educational, Virtual, Ideological and Market Contexts: A Case Analysis of Controversy

    Science.gov (United States)

    Reifel, Stuart

    2009-01-01

    The purpose of this study was to explore an example of girls' doll play in contemporary US culture, including its virtual, political, marketing, and other contextual meanings. The narrative that provoked the analysis was a brief news report about a controversial school function--a school fund-raiser fashion show featuring American Girl doll…

  13. User Experience Design of History Game: An Analysis Review and Evaluation Study for Malaysia Context

    Science.gov (United States)

    Wong, Seng Yue; Ghavifekr, Simin

    2018-01-01

    User experience (UX) and user interface design of an educational game are important in enhancing and sustaining the utilisation of Game Based Learning (GBL) in learning history. Thus, this article provides a detailed literature review on history learning problems, as well as previous studies on user experience in game design. Future studies on…

  14. The informational subject in the contemporary context. An analysis from the epistemology of informational community identity

    Directory of Open Access Journals (Sweden)

    Miguel Angel Rendón-Rojas

    2012-04-01

    Full Text Available The Epistemology of Informational Community Identity (ECI-I is proposed as a toolbox for the analysis of informational reality within categories as contextual paradigm, informational subject and informational entity, built ex profeso for this theoretical-methodological analysis. The concepts of information user´s and informational subject are distinguished, the latest, to seek an answer from a concrete social enclave within a particular community and its interrelationships with others, to under go a process of self construction, from which specific information needs arise. And the user needs to seek concrete answer after formal questioning many facts occurring in a consumerist, unequal and alienating world. So the emphasis is put on the need for an interdisciplinary approach between social theory and library science in the study of the documentary information world of particular informational subjects, which is often marginalized and excluded

  15. Guidelines for reliability analysis of digital systems in PSA context. Phase 1 status report

    International Nuclear Information System (INIS)

    Authen, S.; Larsson, J.; Bjoerkman, K.; Holmberg, J.-E.

    2010-12-01

    Digital protection and control systems are appearing as upgrades in older nuclear power plants (NPPs) and are commonplace in new NPPs. To assess the risk of NPP operation and to determine the risk impact of digital system upgrades on NPPs, quantitative reliability models are needed for digital systems. Due to the many unique attributes of these systems, challenges exist in systems analysis, modeling and in data collection. Currently there is no consensus on reliability analysis approaches. Traditional methods have clearly limitations, but more dynamic approaches are still in trial stage and can be difficult to apply in full scale probabilistic safety assessments (PSA). The number of PSAs worldwide including reliability models of digital I and C systems are few. A comparison of Nordic experiences and a literature review on main international references have been performed in this pre-study project. The study shows a wide range of approaches, and also indicates that no state-of-the-art currently exists. The study shows areas where the different PSAs agree and gives the basis for development of a common taxonomy for reliability analysis of digital systems. It is still an open matter whether software reliability needs to be explicitly modelled in the PSA. The most important issue concerning software reliability is proper descriptions of the impact that software-based systems has on the dependence between the safety functions and the structure of accident sequences. In general the conventional fault tree approach seems to be sufficient for modelling reactor protection system kind of functions. The following focus areas have been identified for further activities: 1. Common taxonomy of hardware and software failure modes of digital components for common use 2. Guidelines regarding level of detail in system analysis and screening of components, failure modes and dependencies 3. Approach for modelling of CCF between components (including software). (Author)

  16. Guidelines for reliability analysis of digital systems in PSA context. Phase 1 status report

    Energy Technology Data Exchange (ETDEWEB)

    Authen, S.; Larsson, J. (Risk Pilot AB, Stockholm (Sweden)); Bjoerkman, K.; Holmberg, J.-E. (VTT, Helsingfors (Finland))

    2010-12-15

    Digital protection and control systems are appearing as upgrades in older nuclear power plants (NPPs) and are commonplace in new NPPs. To assess the risk of NPP operation and to determine the risk impact of digital system upgrades on NPPs, quantitative reliability models are needed for digital systems. Due to the many unique attributes of these systems, challenges exist in systems analysis, modeling and in data collection. Currently there is no consensus on reliability analysis approaches. Traditional methods have clearly limitations, but more dynamic approaches are still in trial stage and can be difficult to apply in full scale probabilistic safety assessments (PSA). The number of PSAs worldwide including reliability models of digital I and C systems are few. A comparison of Nordic experiences and a literature review on main international references have been performed in this pre-study project. The study shows a wide range of approaches, and also indicates that no state-of-the-art currently exists. The study shows areas where the different PSAs agree and gives the basis for development of a common taxonomy for reliability analysis of digital systems. It is still an open matter whether software reliability needs to be explicitly modelled in the PSA. The most important issue concerning software reliability is proper descriptions of the impact that software-based systems has on the dependence between the safety functions and the structure of accident sequences. In general the conventional fault tree approach seems to be sufficient for modelling reactor protection system kind of functions. The following focus areas have been identified for further activities: 1. Common taxonomy of hardware and software failure modes of digital components for common use 2. Guidelines regarding level of detail in system analysis and screening of components, failure modes and dependencies 3. Approach for modelling of CCF between components (including software). (Author)

  17. Stakeholder Analysis on Boycott Movement: A Preliminary Study Using Media Contexts

    Directory of Open Access Journals (Sweden)

    Kresno Agus Hendarto

    2011-12-01

    Full Text Available Just like the celebrities, social movement depends, to an extent, on media in communicating its activities to the public. The relationship between social movement and media is transactional. On the one hand, social movement needs media to disseminate its activities. On the other hand, media needs social movement as the news source. Scant (beyond very few notable exceptions empirical research is not available on boycott product as a social movement and stakeholder analysis in Indonesia. The objective of this study is to perform stakeholder analysis on boycott product as a social movement. To do so, the study attempts to answer some questions: (i what are the trigger and root cause of boycott movement?; (ii what are the interest and influence of each stakeholder on boycott movement?; (iii how is the existing relationship among stakeholders?; and (iv among the stakeholders, which group does get priority? The news about boycott was collected from national media. The news was then analyzed by content analysis. The results show that in the case of boycott, many parties are involved. However, firms’ management has to give priority to consumers, special interest groups, and the gov-ernment. Attention can be manifested in a continuous and sustainable dialogue with them.

  18. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy

    DEFF Research Database (Denmark)

    So, Jonathan; Pasculescu, Adrian; Dai, Anna Y.

    2015-01-01

    phosphoproteomics. With these protein interaction maps, we modeled information flow through the networks and identified apoptosis-modifying kinases that are highly connected to regulated substrates downstream of TRAIL. The results of this analysis provide a resource of potential targets for the development of TRAIL...

  19. Comparative analysis of chicken chromosome 28 provides new clues to the evolutionary fragility of gene-rich vertebrate regions

    NARCIS (Netherlands)

    Gordon, L.; Yang, S.; Tran-Gyamfi, M.; Baggott, D.; Christensen, M.; Hamilton, A.; Crooijmans, R.P.M.A.; Groenen, M.A.M.; Lucas, S.; Ovcharenko, I.; Stubbs, L.

    2007-01-01

    The chicken genome draft sequence has provided a valuable resource for studies of an important agricultural and experimental model species and an important data set for comparative analysis. However, some of the most gene-rich segments are missing from chicken genome draft assemblies, limiting the

  20. Measuring Practicing Clinicians' Information Literacy. An Exploratory Analysis in the Context of Panel Management.

    Science.gov (United States)

    Dixon, Brian E; Barboza, Katherine; Jensen, Ashley E; Bennett, Katelyn J; Sherman, Scott E; Schwartz, Mark D

    2017-02-15

    As healthcare moves towards technology-driven population health management, clinicians must adopt complex digital platforms to access health information and document care. This study explored information literacy, a set of skills required to effectively navigate population health information systems, among primary care providers in one Veterans' Affairs (VA) medical center. Information literacy was assessed during an 8-month randomized trial that tested a population health (panel) management intervention. Providers were asked about their use and comfort with two VA digital tools for panel management at baseline, 16 weeks, and post-intervention. An 8-item scale (range 0-40) was used to measure information literacy (Cronbach's α=0.84). Scores between study arms and provider types were compared using paired t-tests and ANOVAs. Associations between self-reported digital tool use and information literacy were measured via Pearson's correlations. Providers showed moderate levels of information literacy (M= 27.4, SD 6.5). There were no significant differences in mean information literacy between physicians (M=26.4, SD 6.7) and nurses (M=30.5, SD 5.2, p=0.57 for difference), or between intervention (M=28.4, SD 6.5) and control groups (M=25.1, SD 6.2, p=0.12 for difference). Information literacy was correlated with higher rates of self-reported information system usage (r=0.547, p=0.001). Clinicians identified data access, accuracy, and interpretability as potential information literacy barriers. While exploratory in nature, cautioning generalizability, the study suggests that measuring and improving clinicians' information literacy may play a significant role in the implementation and use of digital information tools, as these tools are rapidly being deployed to enhance communication among care teams, improve health care outcomes, and reduce overall costs.

  1. Should English healthcare providers be penalised for failing to collect patient-reported outcome measures? A retrospective analysis.

    Science.gov (United States)

    Gutacker, Nils; Street, Andrew; Gomes, Manuel; Bojke, Chris

    2015-08-01

    The best practice tariff for hip and knee replacement in the English National Health Service (NHS) rewards providers based on improvements in patient-reported outcome measures (PROMs) collected before and after surgery. Providers only receive a bonus if at least 50% of their patients complete the preoperative questionnaire. We determined how many providers failed to meet this threshold prior to the policy introduction and assessed longitudinal stability of participation rates. Retrospective observational study using data from Hospital Episode Statistics and the national PROM programme from April 2009 to March 2012. We calculated participation rates based on either (a) all PROM records or (b) only those that could be linked to inpatient records; constructed confidence intervals around rates to account for sampling variation; applied precision weighting to allow for volume; and applied risk adjustment. NHS hospitals and private providers in England. NHS patients undergoing elective unilateral hip and knee replacement surgery. Number of providers with participation rates statistically significantly below 50%. Crude rates identified many providers that failed to achieve the 50% threshold but there were substantially fewer after adjusting for uncertainty and precision. While important, risk adjustment required restricting the analysis to linked data. Year-on-year correlation between provider participation rates was moderate. Participation rates have improved over time and only a small number of providers now fall below the threshold, but administering preoperative questionnaires remains problematic in some providers. We recommend that participation rates are based on linked data and take into account sampling variation. © The Royal Society of Medicine.

  2. Leaders in Interdependent Contexts Suppress Nonverbal Assertiveness: A Multilevel Analysis of Japanese University Club Leaders' and Members' Rank Signaling.

    Science.gov (United States)

    Ito, Atsuki; Gobel, Matthias S; Uchida, Yukiko

    2018-01-01

    Previous research has shown that leadership is signaled through nonverbal assertiveness. However, those studies have been mostly conducted in individualistic cultural contexts, such as in the U.S. Here, we suggest that one important strategy for goal attainment in collectivistic cultures is for leaders to self-regulate their behaviors. Thus, contrary to the previous evidence from individualistic cultural contexts, in collectivistic cultural contexts, leaders might suppress nonverbal assertiveness. To test this possibility, we assessed nonverbal behaviors (NVB) of Japanese leaders and members, and how they were evaluated by observers. We recruited Japanese leaders and members of university clubs and video-recorded them while introducing their club. Then, we coded their nonverbal rank signaling behavior. Finally, we asked a new set of naïve observers to watch these video-clips and to judge targets' suitability for being possible club leaders. Results of a multilevel analysis (level 1: individual participants, level 2: clubs) suggested that the more the club culture focused on tasks (rather than relationships), the more likely were leaders (but not members) of those clubs to suppress their nonverbal assertiveness. Naïve observers judged individuals who restrained from emitting nonverbal assertiveness as being more suitable and worthy club leaders. Thus, our findings demonstrate the cultural fit between contextual effects at the collective level (i.e., cultural orientation of a group) and the signaling and perceiving of social ranks at the individual level (i.e., suppression of nonverbal assertiveness). We discuss the importance of studying the cultural fit between the collective reality that people inhabit and people's psychology for future research in cultural psychology.

  3. Leaders in Interdependent Contexts Suppress Nonverbal Assertiveness: A Multilevel Analysis of Japanese University Club Leaders' and Members' Rank Signaling

    Directory of Open Access Journals (Sweden)

    Atsuki Ito

    2018-05-01

    Full Text Available Previous research has shown that leadership is signaled through nonverbal assertiveness. However, those studies have been mostly conducted in individualistic cultural contexts, such as in the U.S. Here, we suggest that one important strategy for goal attainment in collectivistic cultures is for leaders to self-regulate their behaviors. Thus, contrary to the previous evidence from individualistic cultural contexts, in collectivistic cultural contexts, leaders might suppress nonverbal assertiveness. To test this possibility, we assessed nonverbal behaviors (NVB of Japanese leaders and members, and how they were evaluated by observers. We recruited Japanese leaders and members of university clubs and video-recorded them while introducing their club. Then, we coded their nonverbal rank signaling behavior. Finally, we asked a new set of naïve observers to watch these video-clips and to judge targets' suitability for being possible club leaders. Results of a multilevel analysis (level 1: individual participants, level 2: clubs suggested that the more the club culture focused on tasks (rather than relationships, the more likely were leaders (but not members of those clubs to suppress their nonverbal assertiveness. Naïve observers judged individuals who restrained from emitting nonverbal assertiveness as being more suitable and worthy club leaders. Thus, our findings demonstrate the cultural fit between contextual effects at the collective level (i.e., cultural orientation of a group and the signaling and perceiving of social ranks at the individual level (i.e., suppression of nonverbal assertiveness. We discuss the importance of studying the cultural fit between the collective reality that people inhabit and people's psychology for future research in cultural psychology.

  4. [Use of psychostimulants in a sexual context: Analysis of cases reported to the French network of Addictovigilance Centers].

    Science.gov (United States)

    Batisse, Anne; Peyrière, Hélène; Eiden, Céline; Courné, Marie-Anne; Djezzar, Samira

    2016-10-01

    The "SLAM" phenomenon is an increasingly popular practice, in Paris and London gay scene, defined by 3 characteristics: injection, sexual party and psychostimulant drugs. The French Medical Agency requested a risk assessment of "SLAM" and more broadly of the use of psychostimulants in a sexual context, by the analysis of complications related to this practice notified to the French Network of Addictovigilance Centers. All cases of complications related to "SLAM" practice, including cases of abuse or dependence, and somatic and psychiatric complications, were analysed. Between January 2008 to December 2013, 51 cases were collected. Users were exclusively men, with a mean age of 40 years, having psychostimulants exposure in a sexual context, mainly in men who have sex with men (MSM) context (100%, n=35). The prevalence of human immunodeficiency virus (HIV) infection was 82% (n=32) with a high level of HIV/hepatitis C virus (HCV) co-infection (50%, n=16). The main psychostimulants reported are synthetic cathinones (89.5%). Cathinones users tended to be polydrug users: 62% also reported use other than psychoactive substances (gamma-butyrolactone [GBL], ketamine, methylenedioxyméthamphetamine [MDMA], lysergic acid diethylamide [LSD]…). The main complications were psychiatric disorders in 50% (psychotic symptoms, agitation, anxiety, suicidal ideas or attempt and forensic problems), acute intoxication in 25% (including 3 deaths), dependence and abuse in 17% and infectious complications in 8% (viral seroconversion). Health professionals as well as users should be aware of the physical (cardiovascular) and behavioural (psychic, fast dependence syndrome) toxicity of cathinones. Risk reduction policy must be targeted to the population of MSM with specific interventions both on risky sexual behavior and substance use. Copyright © 2016 Société française de pharmacologie et de thérapeutique. Published by Elsevier Masson SAS. All rights reserved.

  5. Conflict resolution and its context from the analysis of behavioural patterns to efficient decision-making

    CERN Document Server

    Carneiro, Davide; Neves, José

    2014-01-01

    This book studies how technological solutions can be used to alleviate the current state of legal systems, with their clogged up courtrooms and inefficient conflict resolution methods. It reviews the shortcomings and disadvantages of traditional and alternative conflict resolution methods and turns to Artificial Intelligence for problem-solving techniques and solutions. The book is divided into four parts. The first part presents a general and systematic analysis of the current state of the legal systems, identifying the main problems and their causes.?It then moves on to present UM Court: a f

  6. Alcohol marketing on YouTube: exploratory analysis of content adaptation to enhance user engagement in different national contexts.

    Science.gov (United States)

    Gupta, Himanshu; Lam, Tina; Pettigrew, Simone; Tait, Robert J

    2018-01-16

    We know little about how social media alcohol marketing is utilized for alcohol promotion in different national contexts. There does not appear to be any academic work on online exposure to alcohol marketing via social media in India, and most of the limited research in Australia has focused on Facebook. Hence, the present study extends previous research by investigating alcohol promotion conducted on an under-researched form of social media (YouTube) in two contrasting geographic contexts. This study examines and compares the types of strategies used by marketers on Indian and Australian alcohol brands with the greatest YouTube presence, and the extent to which users engage with these strategies. The 10 alcohol brands per country with the greatest YouTube presence were identified based on the number of 'subscriptions'. The number of videos, views per video, and the type of content within the videos were collected for each brand. The data were analyzed using an inductive coding approach, using NVivo 10. The targeted brands had gathered 98,881 subscriptions (Indian brands: n = 13,868; Australian brands: n = 85,013). The type of marketing strategies utilized by brands were a mix of those that differed by country (e.g. sexually suggestive content in India and posts related to the brand's tradition or heritage in Australia) and generic approaches (e.g. encouraging time- and event-specific drinking; demonstrations of food/cocktail recipes; camaraderie; competitions and prize draws; and brand sponsorship at music, sports, and fashion events). This cross-national comparison demonstrates that YouTube provides alcohol marketers with an advertising platform where they utilize tailored marketing approaches to cater to specific national contexts and develop content on the cultural meanings users invoke in their interactions with these strategies. Those exposed to alcohol marketing on YouTube are likely to include those under the legal drinking age.

  7. Relative risk analysis of several manufactured nanomaterials: an insurance industry context.

    Science.gov (United States)

    Robichaud, Christine Ogilvie; Tanzil, Dicksen; Weilenmann, Ulrich; Wiesner, Mark R

    2005-11-15

    A relative risk assessment is presented for the industrial fabrication of several nanomaterials. The production processes for five nanomaterials were selected for this analysis, based on their current or near-term potential for large-scale production and commercialization: single-walled carbon nanotubes, bucky balls (C60), one variety of quantum dots, alumoxane nanoparticles, and nano-titanium dioxide. The assessment focused on the activities surrounding the fabrication of nanomaterials, exclusive of any impacts or risks with the nanomaterials themselves. A representative synthesis method was selected for each nanomaterial based on its potential for scaleup. A list of input materials, output materials, and waste streams for each step of fabrication was developed and entered into a database that included key process characteristics such as temperature and pressure. The physical-chemical properties and quantities of the inventoried materials were used to assess relative risk based on factors such as volatility, carcinogenicity, flammability, toxicity, and persistence. These factors were first used to qualitatively rank risk, then combined using an actuarial protocol developed by the insurance industry for the purpose of calculating insurance premiums for chemical manufacturers. This protocol ranks three categories of risk relative to a 100 point scale (where 100 represents maximum risk): incident risk, normal operations risk, and latent contamination risk. Results from this analysis determined that relative environmental risk from manufacturing each of these five materials was comparatively low in relation to other common industrial manufacturing processes.

  8. Trend Analysis of Worldwide FDI Flows in the Context of Promoting Sustainable Development and National Interest

    Directory of Open Access Journals (Sweden)

    Alina Georgeta Ailincă

    2016-10-01

    Full Text Available About FDI there are numerous studies, some of them have mostly theoretical character and others mostly practical. This article aims at capturing and analyzing the most important trends in the short, medium and long term on FDI flows worldwide, thus this study has a rather practical approach. Also, the paper aims to discern how FDI flows may influence the sustainable development and the national interest. The analysis starts from studying the past in the most significant developments of the world economy in terms of inflows of investment attraction, drawing marginally some advantages or disadvantages of joining a political entity with regional vocation (e.g. European Union or a currency area (e.g. E.M.U.. It should also be noted that, beyond the analysis of past trends, the direction towards which worldwide foreign direct investment (FDI should be considered in relationship with the ability to infer certain areas which in future can attract FDI for a sustainable and balanced national economy development, serving to the national interest. Thus, the article aims, through a broad set of indicators, to seize these structural or cyclical advantages of world economies and, to the extent that can be applied to the Romanian economy, to contribute to the restructuring of objectives of macroeconomic policies in order to mobilize the country's potential to attract FDI.

  9. Stakeholder analysis in the portuguese artificial reef context: winners and losers

    Directory of Open Access Journals (Sweden)

    Jorge Ramos

    2011-01-01

    Full Text Available In this stakeholder analysis related to the artificial reef (AR program located in the Algarve (Southern Portugal mainland 21 different stakeholder clusters were identified. Stakeholders were classified as primary, secondary and external. It was found that stakeholder interaction with the structures can be of private, public or cooperative interest. In the analysis there were also identified and mapped the impact of the program on stakeholders and their power to influence the ARs' outcomes. Stakeholders' interactions with the ARs were studied, along with their likely attitudes and behavior towards the man-made structures. Finally, all stakeholder clusters were classified according to their expected degree of involvement throughout the different AR stages. The purpose of this stakeholder analysis was to find out winners and losers connected with the reef deployment. It was found that most stakeholder clusters were affected positively, but also four clusters affected negatively. However, it is believed that those that may be affected negatively do not pose a serious threat to the expected AR development along its lifetime.Nesta análise de intervenientes relativa ao programa de recifes artificiais (RAs localizado na costa do Algarve (Sul de Portugal continental foram identificados 21 grupos de atores distintos. Os intervenientes foram classificados em 3 grupos: primários, secundários e externos. Verificou-se que o interesse dos intervenientes face às estruturas recifais (interação pode ser do tipo privado, público ou cooperativo. Na análise foram identificados os impactos do projeto sobre os intervenientes e o poder destes para influenciar os resultados do programa recifal. Foram definidas quais as interações e possíveis atitudes e comportamento dos intervenientes em relação aos RAs. Finalmente, todos os grupos de intervenientes foram classificados de acordo com o grau de envolvimento esperado ao longo das diferentes fases do programa

  10. Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context.

    Science.gov (United States)

    Chiu, Hua-Sheng; Somvanshi, Sonal; Patel, Ektaben; Chen, Ting-Wen; Singh, Vivek P; Zorman, Barry; Patil, Sagar L; Pan, Yinghong; Chatterjee, Sujash S; Sood, Anil K; Gunaratne, Preethi H; Sumazin, Pavel

    2018-04-03

    Long noncoding RNAs (lncRNAs) are commonly dysregulated in tumors, but only a handful are known to play pathophysiological roles in cancer. We inferred lncRNAs that dysregulate cancer pathways, oncogenes, and tumor suppressors (cancer genes) by modeling their effects on the activity of transcription factors, RNA-binding proteins, and microRNAs in 5,185 TCGA tumors and 1,019 ENCODE assays. Our predictions included hundreds of candidate onco- and tumor-suppressor lncRNAs (cancer lncRNAs) whose somatic alterations account for the dysregulation of dozens of cancer genes and pathways in each of 14 tumor contexts. To demonstrate proof of concept, we showed that perturbations targeting OIP5-AS1 (an inferred tumor suppressor) and TUG1 and WT1-AS (inferred onco-lncRNAs) dysregulated cancer genes and altered proliferation of breast and gynecologic cancer cells. Our analysis indicates that, although most lncRNAs are dysregulated in a tumor-specific manner, some, including OIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergistically dysregulate cancer pathways in multiple tumor contexts. Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved.

  11. The problematization of transmediation in the journalistic context: an analysis of transmedia storytelling from feature articles

    Directory of Open Access Journals (Sweden)

    Yuri Borges de Araújo

    2015-09-01

    Full Text Available The concept of transmedia storytelling (JENKINS, 2009a has been gaining acceptance and application in the most diverse fields of communication, including journalism. However, such uses do not often take into account the characteristics of the area studied. This paper aims to problematize the transmedia storytelling (TS within the field of journalism through three sources: the concept developed by Fechine et al. (2011, 2012, 2013 throughout a much wider phenomenon, the transmediation; studies that aim to characterize the journalistic discourse (CHARAUDEAU, 2009a, 2009b; and the theoretical tradition about newsmaking. Therefore, we propose the concepts of “transmedia journalistic content” and “transmedia journalism”, which subsume transmedia storytelling itself. Lastly, it will be presented an analysis on how transmedia storytelling takes place in two specific journalistic productions in order to characterize its place in a broader problematization of transmediation in journalism.

  12. Greenlandic water and sanitation-a context oriented analysis of system challenges towards local sustainable development.

    Science.gov (United States)

    Hendriksen, Kåre; Hoffmann, Birgitte

    2017-08-28

    Today, as Greenland focuses on more economic and cultural autonomy, the continued development of societal infrastructure systems is vital. At the same time, pressure is put on the systems by a lack of financial resources and locally based professional competences as well as new market-based forms of organization. Against this background, the article discusses the challenges facing Greenland's self-rule in relation to further develop the existing water and wastewater systems so that they can contribute to the sustainable development of Greenland. The article reviews the historical development of the water supply and wastewater system. This leads to an analysis of the sectorisation, which in recent decades has reorganized the Greenlandic infrastructures, and of how this process is influencing local sustainable development. The article discusses the socio-economic and human impacts and points to the need for developing the water and sanitation system to support not only hygiene and health, but also local sustainable development.

  13. Comparative analysis of chosen transforms in the context of de-noising harmonic signals

    Directory of Open Access Journals (Sweden)

    Artur Zacniewski

    2015-09-01

    Full Text Available In the article, comparison of popular transforms used i.a. in denoising harmonical signals was presented. The division of signals submitted to mathematical analysis was shown and chosen transforms such as Short Time Fourier Transform, Wigner-Ville Distribution, Wavelet Transform and Discrete Cosine Transform were presented. Harmonic signal with white noise added was submitted for research. During research, the parameters of noise were changed to analyze the effects of using particular transform on noised signal. The importance of right choice for transform and its parameters (different for particular kind of transform was shown. Small changes in parameters or different functions used in transform can lead to considerably different results.[b]Keywords[/b]: denoising of harmonical signals, wavelet transform, discrete cosine transform, DCT

  14. Interpretations of alternative uncertainty representations in a reliability and risk analysis context

    International Nuclear Information System (INIS)

    Aven, T.

    2011-01-01

    Probability is the predominant tool used to measure uncertainties in reliability and risk analyses. However, other representations also exist, including imprecise (interval) probability, fuzzy probability and representations based on the theories of evidence (belief functions) and possibility. Many researchers in the field are strong proponents of these alternative methods, but some are also sceptical. In this paper, we address one basic requirement set for quantitative measures of uncertainty: the interpretation needed to explain what an uncertainty number expresses. We question to what extent the various measures meet this requirement. Comparisons are made with probabilistic analysis, where uncertainty is represented by subjective probabilities, using either a betting interpretation or a reference to an uncertainty standard interpretation. By distinguishing between chances (expressing variation) and subjective probabilities, new insights are gained into the link between the alternative uncertainty representations and probability.

  15. The Analysis of the IFRS Adoption Effects on the Accounting Quality in the European Context

    Directory of Open Access Journals (Sweden)

    Tudor Liviu-ALexandru

    2017-01-01

    Full Text Available The purpose of this paper is to analyze the scientific literature dedicated to IFRS implementation process in order to recognize and understand the impact of the norms related to the quality of the information presented in financial statements. The research methodology used for this purpose is based on an analysis of 24 academic papers published between 2000 and 2015, available on international scientific databases such as: Emerald, ScienceDirect, ProQuest and SSRN. The review presents the economic consequences of the quality accounting improvement as a result of the adoption of IFRS norms. In the same time, the disclosure of the information represents a significant role in lowering the cost of equity regarding the company’s economic level.

  16. Value generation in the context of manufacturing strategy: an analysis in shoe manufactories

    Directory of Open Access Journals (Sweden)

    Sergio Evangelista Silva

    2015-02-01

    Full Text Available The manufacturing function has the role of provide to the customers products with generate value. However this task is not unique of this function, it has to work with the functions research and development (R&D and marketing and sales (M&S. This paper call these three functions as generating value functions, and discuss their mutual role in the process of generating value in the products of a firm. The validation of this model is performed by three comparative case studies, conducted in three shoe manufactories (SMs, with different value generation strategies. The empirical study shows that the mutual role of generating value functions in the value generating process, and that the configuration and the relative role of each function change according to the firm strategy followed.

  17. Elaboration Likelihood Model and an Analysis of the Contexts of Its Application

    Directory of Open Access Journals (Sweden)

    Aslıhan Kıymalıoğlu

    2014-12-01

    Full Text Available Elaboration Likelihood Model (ELM, which supports the existence of two routes to persuasion: central and peripheral routes, has been one of the major models on persuasion. As the number of studies in the Turkish literature on ELM is limited, a detailed explanation of the model together with a comprehensive literature review was considered to be contributory for this gap. The findings of the review reveal that the model was mostly used in marketing and advertising researches, that the concept most frequently used in elaboration process was involvement, and that argument quality and endorser credibility were the factors most often employed in measuring their effect on the dependant variables. The review provides valuable insights as it presents a holistic view of the model and the variables used in the model.

  18. Identifying the Types of Support Needed by Interprofessional Teams Providing Pediatric End-of-Life Care: A Thematic Analysis.

    Science.gov (United States)

    Riotte, Clare O; Kukora, Stephanie K; Keefer, Patricia M; Firn, Janice I

    2018-04-01

    Despite the number of interprofessional team members caring for children at the end of life, little evidence exists on how institutions can support their staff in providing care in these situations. We sought to evaluate which aspects of the hospital work environment were most helpful for multidisciplinary team members who care for patients at the end of life and identify areas for improvement to better address staff needs. Qualitative thematic analysis was completed of free-text comments from a survey distributed to interprofessional staff members involved in the care of a recently deceased pediatric patient. A total of 2701 surveys were sent; 890 completed. Free-text responses were provided by 306 interprofessional team members. Interprofessional team members involved in the care of a child who died at a 348 bed academic children's hospital in the Midwestern United States. Realist thematic analysis of free-text responses was completed in Dedoose using a deductive and inductive approach with line-by-line coding. Descriptive statistics of demographic information was completed using Excel. Thematic analysis of the 306 free-text responses identified three main support-related themes. Interprofessional team members desire to have (1) support through educational efforts such as workshops, (2) support from colleagues, and (3) support through institutional practices. Providers who participate in end-of-life work benefit from ongoing support through education, interpersonal relationships, and institutional practices. Addressing these areas from an interprofessional perspective enables staff to provide the optimal care for patients, patients' families, and themselves.

  19. Functional electrical stimulation and ankle foot orthoses provide equivalent therapeutic effects on foot drop: A meta-analysis providing direction for future research

    Directory of Open Access Journals (Sweden)

    Sarah Prenton

    2017-10-01

    Full Text Available Objective: To compare the randomized controlled trial evidence for therapeutic effects on walking of functional electrical stimulation and ankle foot orthoses for foot drop caused by central nervous system conditions. Data sources: MEDLINE, CINAHL, Cochrane Central Register of Controlled Trials, REHABDATA, PEDro, NIHR Centre for Reviews and Dissemination, Scopus and clinicaltrials.gov. Study selection: One reviewer screened titles/abstracts. Two independent reviewers then screened the full articles. Data extraction: One reviewer extracted data, another screened for accuracy. Risk of bias was assessed by 2 independent reviewers using the Cochrane Risk of Bias Tool. Data synthesis: Eight papers were eligible; 7 involving participants with stroke and 1 involving participants with cerebral palsy. Two papes reporting different measures from the same trial were grouped, resulting in 7 synthesized randomized controlled trials (n= 464. Meta-analysis of walking speed at final assessment (p = 0.46, for stroke participants (p = 0.54 and after 4–6 weeks’ use (p = 0.49 showed equal improvement for both devices. Conclusion: Functional electrical stimulation and ankle foot orthoses have an equally positive therapeutic effect on walking speed in non-progressive central nervous system diagnoses. The current randomized controlled trial evidence base does not show whether this improvement translates into the user’s own environment or reveal the mechanisms that achieve that change. Future studies should focus on measuring activity, muscle activity and gait kinematics. They should also report specific device details, capture sustained therapeutic effects and involve a variety of central nervous system diagnoses.

  20. Psychological Trauma in the Context of Familial Relationships: A Concept Analysis.

    Science.gov (United States)

    Isobel, Sophie; Goodyear, Melinda; Foster, Kim

    2017-01-01

    Many forms of psychological trauma are known to develop interpersonally within important relationships, particularly familial. Within the varying theoretical constructs of psychological traumas, and distinct from the processes of diagnosis, there is a need to refine the scope and definitions of psychological traumas that occur within important familial relationships to ensure a cohesive evidence base and fidelity of the concept in application to practice. This review used a philosophical inquiry methodology of concept analysis to identify the definitions, antecedents, characteristics, and consequences of the varying conceptualizations of psychological trauma occurring within important relationships. Interactions between concepts of interpersonal trauma, relational trauma, betrayal trauma, attachment trauma, developmental trauma, complex trauma, cumulative trauma, and intergenerational trauma are presented. Understanding of the discrete forms and pathways of transmission of psychological trauma between individuals, including transgenerationally within families, creates opportunities for prevention and early intervention within trauma-focused practice. This review found that concepts of psychological trauma occurring within familial relationships are not exclusive of each other but overlap in their encompassment of events and circumstances as well as the effect on individuals of events in the short term and long term. These traumas develop and are transmitted in the space between people, both purposefully and incidentally, and have particularly profound effects when they involve a dependent infant or child. Linguistic and conceptual clarity is paramount for trauma research and practice.

  1. Scanpath-based analysis of objects conspicuity in context of human vision physiology.

    Science.gov (United States)

    Augustyniak, Piotr

    2007-01-01

    This paper discusses principal aspects of objects conspicuity investigated with use of an eye tracker and interpreted on the background of human vision physiology. Proper management of objects conspicuity is fundamental in several leading edge applications in the information society like advertisement, web design, man-machine interfacing and ergonomics. Although some common rules of human perception are applied since centuries in the art, the interest of human perception process is motivated today by the need of gather and maintain the recipient attention by putting selected messages in front of the others. Our research uses the visual tasks methodology and series of progressively modified natural images. The modifying details were attributed by their size, color and position while the scanpath-derived gaze points confirmed or not the act of perception. The statistical analysis yielded the probability of detail perception and correlations with the attributes. This probability conforms to the knowledge about the retina anatomy and perception physiology, although we use noninvasive methods only.

  2. [Compressive-spectral analysis of EEG in patients with panic attacks in the context of different psychiatric diseases].

    Science.gov (United States)

    Tuter, N V; Gnezditskiĭ, V V

    2008-01-01

    Panic disorders (PD) which develop in the context of different psychiatric diseases (neurotic, personality disorder and schizotypal disorders) have their own clinical and neurophysiological features. The results of compressive-spectral analysis of EEG (CSA EEG) in patients with panic attack were different depending on the specifics of initial psychiatric status. EEG parameters in patients differed from those in controls. The common feature for all PD patients was the lower spectral density of theta-, alpha- and beta-bands as well as total spectral density without any alterations of region distribution. The decrease of electrical activity of activation systems was found in the groups with neurotic and schizotypal disorders and that of inhibition systems - in the group with schizotypal disorders. The EEG results did not suggest any depression of activation systems in patients with specific personality disorders. The data obtained with CSA EEG mirror the integrative brain activity which determinad of the appearance of PA as well as of nosology of psychiatre disease.

  3. AN ANALYSIS OF UNEMPLOYMENT IN THE COUNTRIES OF EASTERN AND CENTRAL EUROPE IN THE CONTEXT OF E.U. ADHERING

    Directory of Open Access Journals (Sweden)

    Adrian\tLiviu\tSCUTARIU

    2015-06-01

    Full Text Available Unemployment is a negative phenomenon that manifests itself in any economy with varying degrees of intensity. In this paper we propose to analyze the evolution of unemployment in the EU. There are countries where economic recession was felt more intense and harder recovered from it, such as Greece or Spain. Within the European Union one notes some differences in unemployment between Member States but also in terms of age groups. In the EU youth unemployment rate is approximately double that the general unemployment rate, but the situation is worse in some countries where youth unemployment rate is even higher. Our analysis also focuses on trends recorded at regional level in Central and Eastern Europe countries in the context of their accession to the EU, highlighting positive developments, which were maintained in the coming years. The unemployment rate decrease is one of the objectives followed by the EU through its policies.

  4. The Joint Airport Weather Studies Project - Current analysis highlights in the aviation safety context

    Science.gov (United States)

    Mccarthy, J.

    1984-01-01

    The principal objective of the Joint Airport Weather Studies Project was to obtain high-resolution velocity, turbulence, and thermodynamic data on a convective outflow called a microburst, an intense downdraft and resulting horizontal outflow near the surface. Data collection occurred during the summer of 1982 near Denver, CO. Data sensors included three pulsed-microwave Doppler and two pulsed CO2 lidar radars, along with 27 Portable Automated Mesonet surface weather stations, the FAA's low-level-wind-shear alert system (LLWSAS), and five instrumented research aircraft. Convective storms occurred on 75 of 91 operational days, with Doppler data being collected on at least 70 microbursts. Analyses reported included a thorough examination of microburst-climatology statistics, the capability of the LLWSAS to detect adequately and accurately the presence of low-altitude wind shear danger to aircraft, the capability of a terminal Doppler radar system development to provide improved wind-shear detection and warning, and progress toward improved wind-shear training for pilots.

  5. Contexts of occurrence of child malnutrition in the district of Villaguay, Entre Ríos, Argentina. A multivariate analysis.

    Directory of Open Access Journals (Sweden)

    María Laura Bergel Sanchís

    Full Text Available The analysis of nutritional status is anthropologically important to address the complex interaction of biological, social, political, economic and cultural factors. To deepen the knowledge about contexts of occurrence of child malnutrition, we analyzed nutritional status in relation to socio-environmental conditions of residence in children between three and six years from Villaguay, Entre Ríos, Argentina. We performed a cross-sectional study of 1,435 school children of both sexes. Body weight and height were measured and prevalence of low height/age (LH/A, low weight/age (LW/A, low BMI/age (LBMI/A, overweight (Ow and obesity (Ob was calculated using World Health Organization reference charts. Socio-environmental information was obtained through a semi-structured survey and processed by Categorical Principal Component Analysis (CatPCA. Anthropometric data showed 1.5% LW/A, 5.2% LH/A; 0.6% LBMI/A, 20.9% Ow and 10.9% Ob. CatPCA allowed us to define four groups (G1-G4 with better (G2, middle (G1 and worst (G4 urban socio-environmental conditions and one with rural characteristics (G3. G4 presented the highest LH/A prevalence and G2 the highest Ow and Ob prevalence (P<0.05. It is concluded that since the distribution of malnutrition was not even it may dependent on the context in which children grow up. Thus, the higher the socio-economic level, the higher the incidence of overweight and obesity. Conversely, at the other end of the social scale, undernutrition and increasing weight excess remained major health problems.

  6. Contexts of occurrence of child malnutrition in the district of Villaguay, Entre Ríos, Argentina. A multivariate analysis.

    Science.gov (United States)

    Bergel Sanchís, María Laura; Cesani, María Florencia; Oyhenart, Evelia Edith

    2017-01-01

    The analysis of nutritional status is anthropologically important to address the complex interaction of biological, social, political, economic and cultural factors. To deepen the knowledge about contexts of occurrence of child malnutrition, we analyzed nutritional status in relation to socio-environmental conditions of residence in children between three and six years from Villaguay, Entre Ríos, Argentina. We performed a cross-sectional study of 1,435 school children of both sexes. Body weight and height were measured and prevalence of low height/age (LH/A), low weight/age (LW/A), low BMI/age (LBMI/A), overweight (Ow) and obesity (Ob) was calculated using World Health Organization reference charts. Socio-environmental information was obtained through a semi-structured survey and processed by Categorical Principal Component Analysis (CatPCA). Anthropometric data showed 1.5% LW/A, 5.2% LH/A; 0.6% LBMI/A, 20.9% Ow and 10.9% Ob. CatPCA allowed us to define four groups (G1-G4) with better (G2), middle (G1) and worst (G4) urban socio-environmental conditions and one with rural characteristics (G3). G4 presented the highest LH/A prevalence and G2 the highest Ow and Ob prevalence (Pmalnutrition was not even it may dependent on the context in which children grow up. Thus, the higher the socio-economic level, the higher the incidence of overweight and obesity. Conversely, at the other end of the social scale, undernutrition and increasing weight excess remained major health problems.

  7. Class-Based Context Quality Optimization For Context Management Frameworks

    DEFF Research Database (Denmark)

    Shawky, Ahmed; Olsen, Rasmus Løvenstein; Pedersen, Jens Myrup

    2012-01-01

    Context-awareness is a key requirement in many of today's networks, services and applications. Context Management systems are in this respect used to provide access to distributed, dynamic context information. The reliability of remotely accessed dynamic context information is challenged by network...

  8. Analysis of ASR Clogging Investigations at Three Australian ASR Sites in a Bayesian Context

    Directory of Open Access Journals (Sweden)

    Peter Dillon

    2016-10-01

    Full Text Available When evaluating uncertainties in developing an aquifer storage and recovery (ASR system, under normal budgetary constraints, a systematic approach is needed to prioritise investigations. Three case studies where field trials have been undertaken, and clogging evaluated, reveal the changing perceptions of viability of ASR from a clogging perspective as a result of the progress of investigations. Two stormwater and one recycled water ASR investigations in siliceous aquifers are described that involved different strategies to evaluate the potential for clogging. This paper reviews these sites, as well as earlier case studies and information relating water quality, to clogging in column studies. Two novel theoretical concepts are introduced in the paper. Bayesian analysis is applied to demonstrate the increase in expected net benefit in developing a new ASR operation by undertaking clogging experiments (that have an assumed known reliability for predicting viability for the injectant treatment options and aquifer material from the site. Results for an example situation demonstrate benefit cost ratios of experiments ranging from 1.5 to 6 and apply if decisions are based on experimental results whether success or failure are predicted. Additionally, a theoretical assessment of clogging rates characterised as acute and chronic is given, to explore their combined impact, for two operating parameters that define the onset of purging for recovery of reversible clogging and the onset of occasional advanced bore rehabilitation to address recovery of chronic clogging. These allow the assessment of net recharge and the proportion of water purged or redeveloped. Both analyses could inform economic decisions and help motivate an improved investigation methodology. It is expected that aquifer heterogeneity will result in differing injection rates among wells, so operational experience will ultimately be valuable in differentiating clogging behaviour under

  9. Regulation – Do or Die: An Analysis of Factors Critical to New Product Development in a Regulatory Context

    Directory of Open Access Journals (Sweden)

    Clare O'Dwyer

    2017-04-01

    Full Text Available This study explores new product development in a strict regulatory and historically secretive environment. Adopting a systems perspective and a mixed methods approach in our research, we examine medical device development in Ireland. Findings indicate that the possession of a regulatory strategy expedites the rate of commercialization, so too does the generation of clear product definitions and marketing claims in the earliest developmental phases. Moreover, results suggest that if the regulated industry strengthens its culture for regulation by prioritizing regulation over speed to market, by encouraging cross-functional team collaborations, and by taking a more proactive approach in post-marketing surveillance activities, it has the potential to improve customer satisfaction and enhance product innovation. This study provides unique empirical data enriched by the homogeneity of its sample. It also contributes guidance to practitioners of new product development within a regulatory context.

  10. An analysis of teaching competence in science teachers involved in the design of context-based curriculum materials

    NARCIS (Netherlands)

    Putter - Smits, de L.G.A.; Taconis, R.; Driel, van J.H.; Jochems, W.M.G.

    2012-01-01

    The committees for the current Dutch context-based innovation in secondary science education employed teachers to design context-based curriculum materials. A study on the learning of science teachers in design teams for context-based curriculum materials is presented in this paper. In a correlation

  11. Partial valuation of the goods and services that it provides the mangrove ecosystem: An integrated ecological-economic analysis

    International Nuclear Information System (INIS)

    Castiblanco R, Carmenza

    2002-01-01

    The article presents a methodology to value the economic benefits of the use of some goods and services that provides the mangrove ecosystem, located in the municipality of Tumaco. An ecological analysis is developed integrated to an economic evaluation that allows expressing in monetary terms some values of use of the mangrove; this value are compared with the profitability that reports the Camaroniculture, productive activity that is constituted at the moment, in the most profitable alternative use

  12. An analysis of market development strategy of a point-of-sale solutions provider's market research database

    OpenAIRE

    Medina, Ahmed

    2007-01-01

    This paper is a strategic analysis of Vivonet Inc. and its restaurant performance-benchmarking tool ZATA. Vivonet is a Point of Sales (POS) systems provider for the hospitality and the retail industry. Its ZATA product captures POS and other related information from restaurants and allows the restaurants to compare their performance with restaurants in their market segment. With ZATA, Vivonet has the opportunity to extend beyond the POS systems segment and compete in the market research i...

  13. Impact of stressors in a natural context on release of cortisol in healthy adult humans: a meta-analysis.

    Science.gov (United States)

    Michaud, Kathy; Matheson, Kimberly; Kelly, Owen; Anisman, Hymie

    2008-05-01

    Increased hypothalamic-pituitary-adrenal (HPA) activation, culminating in elevated circulating cortisol levels is a fundamental response to stressors. In animals, this neuroendocrine change is highly reliable and marked (approximately 5-10-fold elevations), whereas in humans, the increase of cortisol release is less pronounced, and even some potent life-threatening events (anticipation of surgery) only elicit modest cortisol increases. Meta-analysis of factors that influenced the increase of cortisol release in a laboratory context pointed to the importance of social evaluative threats and stressor controllability in accounting for the cortisol rise. The present meta-analysis, covering the period from 1978 through March 2007, was undertaken to identify the factors most closely aligned with cortisol increases in natural settings. It appeared that stressor chronicity was fundamental in predicting cortisol changes; however, this variable is often confounded by the stressor type, the stressor's controllability, as well as contextual factors, making it difficult to disentangle their relative contributions to the cortisol response. Moreover, several experiential factors (e.g. previous stressor experiences) may influence the cortisol response to ongoing stressors, but these are not readily deduced through a meta-analysis. Nevertheless, there are ample data suggesting that stressful events, through their actions on cortisol levels and reactivity, may influence psychological and physical pathology.

  14. Report on gas sales regulated tariffs of historical providers (others than GDF Suez). Analysis of supply costs and of non-supply related costs - May 2015. Deliberation of the Commission for Energy Regulation of the 27 May 2015 bearing approval of the report of analysis of supply and non-supply related costs used as a basis for the calculation of the evolution of natural gas sales regulated tariffs of historical providers

    International Nuclear Information System (INIS)

    Edwige, Catherine; Padova, Yann; Sotura, Jean-Pierre

    2015-05-01

    After a presentation of the context and objectives of works performed by the CRE (the French commission for energy regulation), and a synthetic presentation of the main conclusions, this report first proposes an assessment for 2014 by presenting and discussing the distribution of costs taken into account in regulated tariffs of historic providers, and by noticing that the CRE is able to give its opinion on cost coverage by revenues only for a limited number of providers. The second part proposes an analysis of provider supply conditions and their evolution perspectives. The last part addresses the perspectives of evolution of non-supply related costs

  15. Independent Analysis of the Flagellum Surface and Matrix Proteomes Provides Insight into Flagellum Signaling in Mammalian-infectious Trypanosoma brucei*

    Science.gov (United States)

    Oberholzer, Michael; Langousis, Gerasimos; Nguyen, HoangKim T.; Saada, Edwin A.; Shimogawa, Michelle M.; Jonsson, Zophonias O.; Nguyen, Steven M.; Wohlschlegel, James A.; Hill, Kent L.

    2011-01-01

    The flagellum of African trypanosomes is an essential and multifunctional organelle that functions in motility, cell morphogenesis, and host-parasite interaction. Previous studies of the trypanosome flagellum have been limited by the inability to purify flagella without first removing the flagellar membrane. This limitation is particularly relevant in the context of studying flagellum signaling, as signaling requires surface-exposed proteins in the flagellar membrane and soluble signaling proteins in the flagellar matrix. Here we employ a combination of genetic and mechanical approaches to purify intact flagella from the African trypanosome, Trypanosoma brucei, in its mammalian-infectious stage. We combined flagellum purification with affinity-purification of surface-exposed proteins to conduct independent proteomic analyses of the flagellum surface and matrix fractions. The proteins identified encompass a broad range of molecular functionalities, including many predicted to function in signaling. Immunofluorescence and RNA interference studies demonstrate flagellum localization and function for proteins identified and provide insight into mechanisms of flagellum attachment and motility. The flagellum surface proteome includes many T. brucei-specific proteins and is enriched for proteins up-regulated in the mammalian-infectious stage of the parasite life-cycle. The combined results indicate that the flagellum surface presents a diverse and dynamic host-parasite interface that is well-suited for host-parasite signaling. PMID:21685506

  16. Confirmatory factor analysis of the Feeding Emotions Scale. A measure of parent emotions in the context of feeding.

    Science.gov (United States)

    Frankel, Leslie; Fisher, Jennifer O; Power, Thomas G; Chen, Tzu-An; Cross, Matthew B; Hughes, Sheryl O

    2015-08-01

    Assessing parent affect is important because studies examining the parent-child dyad have shown that parent affect has a profound impact on parent-child interactions and related outcomes. Although some measures that assess general affect during daily lives exist, to date there are only few tools that assess parent affect in the context of feeding. The aim of this study was to develop an instrument to measure parent affect specific to the feeding context and determine its validity and reliability. A brief instrument consisting of 20 items was developed that specifically asks how parents feel during the feeding process. This brief instrument draws on the structure of a well-validated general affect measure. A total of 296 Hispanic and Black Head Start parents of preschoolers completed the Feeding Emotions Scale along with other parent-report measures as part of a larger study designed to better understand feeding interactions during the dinner meal. Confirmatory factor analysis supported a two-factor model with independent subscales of positive affect and negative affect (Cronbach's alphas of 0.85 and 0.84, respectively). Concurrent and convergent construct validity was evaluated by correlating the subscales of the Feeding Emotions Scale with positive emotionality and negative emotionality from the Differential Emotions Scale - a measure of general adult emotions. Concurrent and convergent criterion validity was evaluated by testing mean differences in affect across parent feeding styles using ANOVA. A significant difference was found across maternal weight status for positive feeding affect. The resulting validated measure can be used to assess parent affect in studies of feeding to better understand how interactions during feeding may impact the development of child eating behaviors and possibly weight status. Copyright © 2015 Elsevier Ltd. All rights reserved.

  17. Non-suicidal self-injury within the school context: Multilevel analysis of teachers' support and peer climate.

    Science.gov (United States)

    Madjar, N; Ben Shabat, S; Elia, R; Fellner, N; Rehavi, M; Rubin, S E; Segal, N; Shoval, G

    2017-03-01

    Recent studies regarding non-suicidal self-injury (NSSI) among adolescents have focused primarily on individual characteristics (e.g., depressive symptoms) and background factors (e.g., parental relationship), whereas less emphasis has been given to the role of school-related factors in NSSI. Therefore, the purpose of the current study was to explore the relationships between teachers' support, peer climate, and NSSI within the school context. The sample consisted of 594 high school students nested within 27 regular classes (54.4% boys; mean age 14.96, SD=1.33 years). The students were evaluated for NSSI behaviors, perception of teacher support, peer climate, relationships with mothers, and depressive symptoms using validated scales. The primary analysis used hierarchical linear modeling (HLM), controlling for gender and age. The main findings indicated that teacher support was positively associated with NSSI at the classroom-level (OR=6.15, 95% CI=2.05-18.5) but negatively associated at the student-level (OR=0.66, 95% CI=0.49-0.89). There was a trend toward an association between positive peer climate and NSSI at the classroom-level (OR=0.43, 95% CI=0.18-1.05), while negative peer climate was associated with NSSI at the student-level (OR=1.37, 95% CI=1.00-1.87). School-related factors are associated with NSSI behaviors among students. Teachers and educators should focus on both individual-level and classroom-level perceptions of school context. Students who feel supported by their teachers and who are exposed to a positive peer climate are less likely to engage in NSSI. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  18. Treatment Analysis in a Cancer Stem Cell Context Using a Tumor Growth Model Based on Cellular Automata.

    Science.gov (United States)

    Monteagudo, Ángel; Santos, José

    2015-01-01

    Cancer can be viewed as an emergent behavior in terms of complex system theory and artificial life, Cellular Automata (CA) being the tool most used for studying and characterizing the emergent behavior. Different approaches with CA models were used to model cancer growth. The use of the abstract model of acquired cancer hallmarks permits the direct modeling at cellular level, where a cellular automaton defines the mitotic and apoptotic behavior of cells, and allows for an analysis of different dynamics of the cellular system depending on the presence of the different hallmarks. A CA model based on the presence of hallmarks in the cells, which includes a simulation of the behavior of Cancer Stem Cells (CSC) and their implications for the resultant growth behavior of the multicellular system, was employed. This modeling of cancer growth, in the avascular phase, was employed to analyze the effect of cancer treatments in a cancer stem cell context. The model clearly explains why, after treatment against non-stem cancer cells, the regrowth capability of CSCs generates a faster regrowth of tumor behavior, and also shows that a continuous low-intensity treatment does not favor CSC proliferation and differentiation, thereby allowing an unproblematic control of future tumor regrowth. The analysis performed indicates that, contrary to the current attempts at CSC control, trying to make CSC proliferation more difficult is an important point to consider, especially in the immediate period after a standard treatment for controlling non-stem cancer cell proliferation.

  19. Treatment Analysis in a Cancer Stem Cell Context Using a Tumor Growth Model Based on Cellular Automata.

    Directory of Open Access Journals (Sweden)

    Ángel Monteagudo

    Full Text Available Cancer can be viewed as an emergent behavior in terms of complex system theory and artificial life, Cellular Automata (CA being the tool most used for studying and characterizing the emergent behavior. Different approaches with CA models were used to model cancer growth. The use of the abstract model of acquired cancer hallmarks permits the direct modeling at cellular level, where a cellular automaton defines the mitotic and apoptotic behavior of cells, and allows for an analysis of different dynamics of the cellular system depending on the presence of the different hallmarks. A CA model based on the presence of hallmarks in the cells, which includes a simulation of the behavior of Cancer Stem Cells (CSC and their implications for the resultant growth behavior of the multicellular system, was employed. This modeling of cancer growth, in the avascular phase, was employed to analyze the effect of cancer treatments in a cancer stem cell context. The model clearly explains why, after treatment against non-stem cancer cells, the regrowth capability of CSCs generates a faster regrowth of tumor behavior, and also shows that a continuous low-intensity treatment does not favor CSC proliferation and differentiation, thereby allowing an unproblematic control of future tumor regrowth. The analysis performed indicates that, contrary to the current attempts at CSC control, trying to make CSC proliferation more difficult is an important point to consider, especially in the immediate period after a standard treatment for controlling non-stem cancer cell proliferation.

  20. Context in a wider context

    Directory of Open Access Journals (Sweden)

    John Traxler

    2011-07-01

    Full Text Available This paper attempts to review and reconsider the role of context in mobile learning and starts by outlining definitions of context-aware mobile learning as the technologies have become more mature, more robust and more widely available and as the notion of context has become progressively richer. The future role of context-aware mobile learning is considered within the context of the future of mobile learning as it moves from the challenges and opportunities of pedagogy and technology to the challenges and opportunities of policy, scale, sustainability, equity and engagement with augmented reality, «blended learning», «learner devices», «user-generated contexts» and the «internet of things». This is essentially a perspective on mobile learning, and other forms of technology-enhanced learning (TEL, where educators and their institutions set the agenda and manage change. There are, however, other perspectives on context. The increasing availability and use of smart-phones and other personal mobile devices with similar powerful functionality means that the experience of context for many people, in the form of personalized or location-based services, is an increasingly social and informal experience, rather than a specialist or educational experience. This is part of the transformative impact of mobility and connectedness on our societies brought about by these universal, ubiquitous and pervasive technologies. This paper contributes a revised understanding of context in the wider context (sic of the transformations taking place in our societies. These are subtle but pervasive transformations of jobs, work and the economy, of our sense of time, space and place, of knowing and learning, and of community and identity. This leads to a radical reconsideration of context as the notions of ‹self› and ‹other› are transformed.

  1. Analysis of technical alternative technologies for the development of context-driven composable environmental representations for JSB

    Science.gov (United States)

    Hummel, John R.; Bergenthal, Jeff J.; Seng, William F.; Moulton, Joseph R., Jr.; Prager, S. D.

    2004-08-01

    The Joint Synthetic Battlespace for the Air Force (JSB-AF) is being developed to provide realistic representations of friendly and threat capabilities and the natural environmental conditions to support a variety of Department of Defense missions including training, mission rehearsal, decision support, acquisition, deployment, employment, operations, and the development of Courses of Action. This paper addresses three critical JSB issues associated with providing environ-mental representations to Modeling and Simulation (M&S) applications. First, how should the requirements for envi-ronmental functionality in a JSB-AF application be collected, analyzed, and used to define an Authoritative Environ-mental Representation (AER)? Second, how can JSB-AF AERs be generated? Third, once an AER has been generated, how should it be "served up" to the JSB-AF components? Our analyses of these issues will be presented from a general M&S perspective, with examples given from a JSB-AF centered view. In the context of this effort, the term "representa-tions" is meant to incorporate both basic environmental "data" (e.g., temperature, pressure, slope, elevation, etc.) and "effects", properties that can be derived from these data using physics-based models or empirical relationship from the fundamental data (e.g., extinction coefficients, radiance, soil moisture strength, etc.) We present a state-of-the-art review of the existing processes and technologies that address these questions.

  2. Small proteins in cyanobacteria provide a paradigm for the functional analysis of the bacterial micro-proteome.

    Science.gov (United States)

    Baumgartner, Desiree; Kopf, Matthias; Klähn, Stephan; Steglich, Claudia; Hess, Wolfgang R

    2016-11-28

    Despite their versatile functions in multimeric protein complexes, in the modification of enzymatic activities, intercellular communication or regulatory processes, proteins shorter than 80 amino acids (μ-proteins) are a systematically underestimated class of gene products in bacteria. Photosynthetic cyanobacteria provide a paradigm for small protein functions due to extensive work on the photosynthetic apparatus that led to the functional characterization of 19 small proteins of less than 50 amino acids. In analogy, previously unstudied small ORFs with similar degrees of conservation might encode small proteins of high relevance also in other functional contexts. Here we used comparative transcriptomic information available for two model cyanobacteria, Synechocystis sp. PCC 6803 and Synechocystis sp. PCC 6714 for the prediction of small ORFs. We found 293 transcriptional units containing candidate small ORFs ≤80 codons in Synechocystis sp. PCC 6803, also including the known mRNAs encoding small proteins of the photosynthetic apparatus. From these transcriptional units, 146 are shared between the two strains, 42 are shared with the higher plant Arabidopsis thaliana and 25 with E. coli. To verify the existence of the respective μ-proteins in vivo, we selected five genes as examples to which a FLAG tag sequence was added and re-introduced them into Synechocystis sp. PCC 6803. These were the previously annotated gene ssr1169, two newly defined genes norf1 and norf4, as well as nsiR6 (nitrogen stress-induced RNA 6) and hliR1(high light-inducible RNA 1) , which originally were considered non-coding. Upon activation of expression via the Cu 2+. responsive petE promoter or from the native promoters, all five proteins were detected in Western blot experiments. The distribution and conservation of these five genes as well as their regulation of expression and the physico-chemical properties of the encoded proteins underline the likely great bandwidth of small protein

  3. Cost-effectiveness analysis of malaria rapid diagnostic test incentive schemes for informal private healthcare providers in Myanmar.

    Science.gov (United States)

    Chen, Ingrid T; Aung, Tin; Thant, Hnin Nwe Nwe; Sudhinaraset, May; Kahn, James G

    2015-02-05

    The emergence of artemisinin-resistant Plasmodium falciparum parasites in Southeast Asia threatens global malaria control efforts. One strategy to counter this problem is a subsidy of malaria rapid diagnostic tests (RDTs) and artemisinin-based combination therapy (ACT) within the informal private sector, where the majority of malaria care in Myanmar is provided. A study in Myanmar evaluated the effectiveness of financial incentives vs information, education and counselling (IEC) in driving the proper use of subsidized malaria RDTs among informal private providers. This cost-effectiveness analysis compares intervention options. A decision tree was constructed in a spreadsheet to estimate the incremental cost-effectiveness ratios (ICERs) among four strategies: no intervention, simple subsidy, subsidy with financial incentives, and subsidy with IEC. Model inputs included programmatic costs (in dollars), malaria epidemiology and observed study outcomes. Data sources included expenditure records, study data and scientific literature. Model outcomes included the proportion of properly and improperly treated individuals with and without P. falciparum malaria, and associated disability-adjusted life years (DALYs). Results are reported as ICERs in US dollars per DALY averted. One-way sensitivity analysis assessed how outcomes depend on uncertainty in inputs. ICERs from the least to most expensive intervention are: $1,169/DALY averted for simple subsidy vs no intervention, $185/DALY averted for subsidy with financial incentives vs simple subsidy, and $200/DALY averted for a subsidy with IEC vs subsidy with financial incentives. Due to decreasing ICERs, each strategy was also compared to no intervention. The subsidy with IEC was the most favourable, costing $639/DALY averted compared with no intervention. One-way sensitivity analysis shows that ICERs are most affected by programme costs, RDT uptake, treatment-seeking behaviour, and the prevalence and virulence of non

  4. Patient and provider perceptions of decision making about use of epidural analgesia during childbirth: a thematic analysis.

    Science.gov (United States)

    Goldberg, Holly Bianca; Shorten, Allison

    2014-01-01

    This study examines the nature of differences in perceptions of decision making between patients and providers about use of epidural analgesia during labor. Thematic analysis was used to identify patterns in written survey responses from 14 patients, 13 labor nurses, and 7 obstetrician-gynecologists. Results revealed patients attempted to place themselves in an informed role in decision making and sought respect for their decisions. Some providers demonstrated paternalism and a tendency to steer patients in the direction of their own preferences. Nurses observed various pressures on decision making, reinforcing the importance of patients being supported to make an informed choice. Differences in perceptions suggest need for improvement in communication and shared decision-making practices related to epidural analgesia use in labor.

  5. Variations in Medicare Reimbursement in Radiation Oncology: An Analysis of the Medicare Provider Utilization and Payment Data Set

    International Nuclear Information System (INIS)

    Vu, Charles C.; Lanni, Thomas B.; Robertson, John M.

    2016-01-01

    Purpose: The purposes of this study were to summarize recently published data on Medicare reimbursement to individual radiation oncologists and to identify the causes of variation in Medicare reimbursement in radiation oncology. Methods and Materials: The Medicare Provider Utilization and Payment Data: Physician and Other Supplier Public Use File (POSPUF), which details nearly all services provided by radiation oncologists in 2012, was used for this study. The data were filtered and analyzed by physician and by billing code. Statistical analysis was performed to identify differences in reimbursements based on sex, rurality, billing of technical services, or location in a certificate of need (CON) state. Results: There were 4135 radiation oncologists who received a total of $1,499,625,803 in payments from Medicare in 2012. Seventy-five percent of radiation oncologists were male. The median reimbursement was $146,453. The code with the highest total reimbursement was 77418 (radiation treatment delivery intensity modulated radiation therapy [IMRT]). The most commonly billed evaluation and management (E/M) code for new visits was 99205 (49%). The most commonly billed E/M code for established visits was 99213 (54%). Forty percent of providers billed none of their new office visits using 99205 (the highest E/M billing code), whereas 34% of providers billed all of their new office visits using 99205. For the 1510 radiation oncologists (37%) who billed technical services, median Medicare reimbursement was $606,008, compared with $93,921 for all other radiation oncologists (P<.001). On multivariate analysis, technical services billing (P<.001), male sex (P<.001), and rural location (P=.007) were predictive of higher Medicare reimbursement. Conclusions: The billing of technical services, with their high capital and labor overhead requirements, limits any comparison in reimbursement between individual radiation oncologists or between radiation oncologists and other

  6. Comparative transcriptome analysis of two oysters, Crassostrea gigas and Crassostrea hongkongensis provides insights into adaptation to hypo-osmotic conditions.

    Directory of Open Access Journals (Sweden)

    Xuelin Zhao

    Full Text Available Environmental salinity creates a key barrier to limit the distribution of most aquatic organisms. Adaptation to osmotic fluctuation is believed to be a factor facilitating species diversification. Adaptive evolution often involves beneficial mutations at more than one locus. Bivalves hold great interest, with numerous species living in waters, as osmoconformers, who maintain the osmotic pressure balance mostly by free amino acids. In this study, 107,076,589 reads from two groups of Crassostrea hongkongensis were produced and the assembled into 130,629 contigs. Transcripts putatively involved in stress-response, innate immunity and cell processes were identified according to Gene ontology and KEGG pathway analyses. Comparing with the transcriptome of C. gigas to characterize the diversity of transcripts between species with osmotic divergence, we identified 182,806 high-quality single nucleotide polymorphisms (SNPs for C. hongkongensis, and 196,779 SNPs for C. gigas. Comparison of 11,602 pairs of putative orthologs allowed for identification of 14 protein-coding genes that experienced strong positive selection (Ka/Ks>1. In addition, 45 genes that may show signs of moderate positive selection (1 ≥ Ka/Ks>0.5 were also identified. Based on Ks ratios and divergence time between the two species published previously, we estimated a neutral transcriptome-wide substitution mutation rate of 1.39 × 10(-9 per site per year. Several genes were differentially expressed across the control and treated groups of each species. This is the first time to sequence the transcriptome of C. hongkongensis and provide the most comprehensive transcriptomic resource available for it. The increasing amount of transcriptome data on Crassostrea provides an excellent resource for phylogenetic analysis. A large number of SNPs identified in this work are expected to provide valuable resources for future marker and genotyping assay development. The analysis of natural

  7. Variations in Medicare Reimbursement in Radiation Oncology: An Analysis of the Medicare Provider Utilization and Payment Data Set

    Energy Technology Data Exchange (ETDEWEB)

    Vu, Charles C.; Lanni, Thomas B.; Robertson, John M., E-mail: JRobertson@beaumont.edu

    2016-04-01

    Purpose: The purposes of this study were to summarize recently published data on Medicare reimbursement to individual radiation oncologists and to identify the causes of variation in Medicare reimbursement in radiation oncology. Methods and Materials: The Medicare Provider Utilization and Payment Data: Physician and Other Supplier Public Use File (POSPUF), which details nearly all services provided by radiation oncologists in 2012, was used for this study. The data were filtered and analyzed by physician and by billing code. Statistical analysis was performed to identify differences in reimbursements based on sex, rurality, billing of technical services, or location in a certificate of need (CON) state. Results: There were 4135 radiation oncologists who received a total of $1,499,625,803 in payments from Medicare in 2012. Seventy-five percent of radiation oncologists were male. The median reimbursement was $146,453. The code with the highest total reimbursement was 77418 (radiation treatment delivery intensity modulated radiation therapy [IMRT]). The most commonly billed evaluation and management (E/M) code for new visits was 99205 (49%). The most commonly billed E/M code for established visits was 99213 (54%). Forty percent of providers billed none of their new office visits using 99205 (the highest E/M billing code), whereas 34% of providers billed all of their new office visits using 99205. For the 1510 radiation oncologists (37%) who billed technical services, median Medicare reimbursement was $606,008, compared with $93,921 for all other radiation oncologists (P<.001). On multivariate analysis, technical services billing (P<.001), male sex (P<.001), and rural location (P=.007) were predictive of higher Medicare reimbursement. Conclusions: The billing of technical services, with their high capital and labor overhead requirements, limits any comparison in reimbursement between individual radiation oncologists or between radiation oncologists and other

  8. Large scale comparative codon-pair context analysis unveils general rules that fine-tune evolution of mRNA primary structure.

    Directory of Open Access Journals (Sweden)

    Gabriela Moura

    Full Text Available BACKGROUND: Codon usage and codon-pair context are important gene primary structure features that influence mRNA decoding fidelity. In order to identify general rules that shape codon-pair context and minimize mRNA decoding error, we have carried out a large scale comparative codon-pair context analysis of 119 fully sequenced genomes. METHODOLOGIES/PRINCIPAL FINDINGS: We have developed mathematical and software tools for large scale comparative codon-pair context analysis. These methodologies unveiled general and species specific codon-pair context rules that govern evolution of mRNAs in the 3 domains of life. We show that evolution of bacterial and archeal mRNA primary structure is mainly dependent on constraints imposed by the translational machinery, while in eukaryotes DNA methylation and tri-nucleotide repeats impose strong biases on codon-pair context. CONCLUSIONS: The data highlight fundamental differences between prokaryotic and eukaryotic mRNA decoding rules, which are partially independent of codon usage.

  9. Thunderstorms and flooding of August 17, 2007, with a context provided by a history of other large storm and flood events in the Black Hills area of South Dakota

    Science.gov (United States)

    Driscoll, Daniel G.; Bunkers, Matthew J.; Carter, Janet M.; Stamm, John F.; Williamson, Joyce E.

    2010-01-01

    The Black Hills area of western South Dakota has a history of damaging flash floods that have resulted primarily from exceptionally strong rain-producing thunderstorms. The best known example is the catastrophic storm system of June 9-10, 1972, which caused severe flooding in several major drainages near Rapid City and resulted in 238 deaths. More recently, severe thunderstorms caused flash flooding near Piedmont and Hermosa on August 17, 2007. Obtaining a thorough understanding of peak-flow characteristics for low-probability floods will require a comprehensive long-term approach involving (1) documentation of scientific information for extreme events such as these; (2) long-term collection of systematic peak-flow records; and (3) regional assessments of a wide variety of peak-flow information. To that end, the U.S. Geological Survey cooperated with the South Dakota Department of Transportation and National Weather Service to produce this report, which provides documentation regarding the August 17, 2007, storm and associated flooding and provides a context through examination of other large storm and flood events in the Black Hills area. The area affected by the August 17, 2007, storms and associated flooding generally was within the area affected by the larger storm of June 9-10, 1972. The maximum observed 2007 precipitation totals of between 10.00 and 10.50 inches occurred within about 2-3 hours in a small area about 5 miles west of Hermosa. The maximum documented precipitation amount in 1972 was 15.0 inches, and precipitation totals of 10.0 inches or more were documented for 34 locations within an area of about 76 square miles. A peak flow of less than 1 cubic foot per second occurred upstream from the 2007 storm extent for streamflow-gaging station 06404000 (Battle Creek near Keystone); whereas, the 1972 peak flow of 26,200 cubic feet per second was large, relative to the drainage area of only 58.6 square miles. Farther downstream along Battle Creek, a 2007

  10. A model for determining when an analysis contains sufficient detail to provide adequate NEPA coverage for a proposed action

    International Nuclear Information System (INIS)

    Eccleston, C.H.

    1994-11-01

    Neither the National Environmental Policy Act (NEPA) nor its subsequent regulations provide substantive guidance for determining the Level of detail, discussion, and analysis that is sufficient to adequately cover a proposed action. Yet, decisionmakers are routinely confronted with the problem of making such determinations. Experience has shown that no two decisionmakers are Likely to completely agree on the amount of discussion that is sufficient to adequately cover a proposed action. one decisionmaker may determine that a certain Level of analysis is adequate, while another may conclude the exact opposite. Achieving a consensus within the agency and among the public can be problematic. Lacking definitive guidance, decisionmakers and critics alike may point to a universe of potential factors as the basis for defending their claim that an action is or is not adequately covered. Experience indicates that assertions are often based on ambiguous opinions that can be neither proved nor disproved. Lack of definitive guidance slows the decisionmaking process and can result in project delays. Furthermore, it can also Lead to inconsistencies in decisionmaking, inappropriate Levels of NEPA documentation, and increased risk of a project being challenged for inadequate coverage. A more systematic and less subjective approach for making such determinations is obviously needed. A paradigm for reducing the degree of subjectivity inherent in such decisions is presented in the following paper. The model is specifically designed to expedite the decisionmaking process by providing a systematic approach for making these determination. In many cases, agencies may find that using this model can reduce the analysis and size of NEPA documents

  11. Peer Interaction and Social Network Analysis of Online Communities with the Support of Awareness of Different Contexts

    Science.gov (United States)

    Lin, Jian-Wei; Mai, Li-Jung; Lai, Yung-Cheng

    2015-01-01

    Although several studies related to social-context awareness (SA) and knowledge-context awareness (KA) argued that each (SA or KA) can individually enhance peer interaction in an online learning community, other studies reached opposite conclusions. These conflicting findings likely stem from different experimental settings. Most importantly, few…

  12. De novo Sequencing and Analysis of Lemongrass Transcriptome Provides First Insights into the Essential Oil Biosynthesis of Aromatic Grasses

    Directory of Open Access Journals (Sweden)

    Seema Meena

    2016-07-01

    Full Text Available Aromatic grasses of the genus Cymbopogon (Poaceae family represent unique group of plants that produce diverse composition of monoterpene rich essential oils, which have great value in flavour, fragrance, cosmetic and aromatherapy industries. Despite the commercial importance of these natural aromatic oils, their biosynthesis at the molecular level remains unexplored. As the first step towards understanding the essential oil biosynthesis, we performed de novo transcriptome assembly and analysis of C. flexuosus (lemongrass by employing Illumina sequencing. Mining of transcriptome data and subsequent phylogenetic analysis led to identification of terpene synthases (TPS, pyrophosphatases (PPase, alcohol dehydrogenases (ADH, aldo-keto reductases (AKR, carotenoid cleavage dioxygenases (CCD, alcohol acetyltransferases (AAT and aldehyde dehydrogenases (ALDH, which are potentially involved in essential oil biosynthesis. Comparative essential oil profiling and mRNA expression analysis in three Cymbopogon species (C. flexuosus, aldehyde type; C. martinii, alcohol type; and C. winterianus, intermediate type with varying essential oil composition indicated the involvement of identified candidate genes in the formation of alcohols, aldehydes and acetates. Molecular modeling and docking further supported the role of identified enzymes in aroma formation in Cymbopogon. Also, simple sequence repeats (SSRs were found in the transcriptome with many linked to terpene pathway genes including the genes potentially involved in aroma biosynthesis. This work provides the first insights into the essential oil biosynthesis of aromatic grasses, and the identified candidate genes and markers can be a great resource for biotechnological and molecular breeding approaches to modulate the essential oil composition.

  13. Quantitative Phosphoproteomic Analysis Provides Insight into the Response to Short-Term Drought Stress in Ammopiptanthus mongolicus Roots

    Directory of Open Access Journals (Sweden)

    Huigai Sun

    2017-10-01

    Full Text Available Drought is one of the major abiotic stresses that negatively affects plant growth and development. Ammopiptanthus mongolicus is an ecologically important shrub in the mid-Asia desert region and used as a model for abiotic tolerance research in trees. Protein phosphorylation participates in the regulation of various biological processes, however, phosphorylation events associated with drought stress signaling and response in plants is still limited. Here, we conducted a quantitative phosphoproteomic analysis of the response of A. mongolicus roots to short-term drought stress. Data are available via the iProx database with project ID IPX0000971000. In total, 7841 phosphorylation sites were found from the 2019 identified phosphopeptides, corresponding to 1060 phosphoproteins. Drought stress results in significant changes in the abundance of 103 phosphopeptides, corresponding to 90 differentially-phosphorylated phosphoproteins (DPPs. Motif-x analysis identified two motifs, including [pSP] and [RXXpS], from these DPPs. Functional enrichment and protein-protein interaction analysis showed that the DPPs were mainly involved in signal transduction and transcriptional regulation, osmotic adjustment, stress response and defense, RNA splicing and transport, protein synthesis, folding and degradation, and epigenetic regulation. These drought-corresponsive phosphoproteins, and the related signaling and metabolic pathways probably play important roles in drought stress signaling and response in A. mongolicus roots. Our results provide new information for understanding the molecular mechanism of the abiotic stress response in plants at the posttranslational level.

  14. De Novo Sequencing and Analysis of Lemongrass Transcriptome Provide First Insights into the Essential Oil Biosynthesis of Aromatic Grasses.

    Science.gov (United States)

    Meena, Seema; Kumar, Sarma R; Venkata Rao, D K; Dwivedi, Varun; Shilpashree, H B; Rastogi, Shubhra; Shasany, Ajit K; Nagegowda, Dinesh A

    2016-01-01

    Aromatic grasses of the genus Cymbopogon (Poaceae family) represent unique group of plants that produce diverse composition of monoterpene rich essential oils, which have great value in flavor, fragrance, cosmetic, and aromatherapy industries. Despite the commercial importance of these natural aromatic oils, their biosynthesis at the molecular level remains unexplored. As the first step toward understanding the essential oil biosynthesis, we performed de novo transcriptome assembly and analysis of C. flexuosus (lemongrass) by employing Illumina sequencing. Mining of transcriptome data and subsequent phylogenetic analysis led to identification of terpene synthases, pyrophosphatases, alcohol dehydrogenases, aldo-keto reductases, carotenoid cleavage dioxygenases, alcohol acetyltransferases, and aldehyde dehydrogenases, which are potentially involved in essential oil biosynthesis. Comparative essential oil profiling and mRNA expression analysis in three Cymbopogon species (C. flexuosus, aldehyde type; C. martinii, alcohol type; and C. winterianus, intermediate type) with varying essential oil composition indicated the involvement of identified candidate genes in the formation of alcohols, aldehydes, and acetates. Molecular modeling and docking further supported the role of identified protein sequences in aroma formation in Cymbopogon. Also, simple sequence repeats were found in the transcriptome with many linked to terpene pathway genes including the genes potentially involved in aroma biosynthesis. This work provides the first insights into the essential oil biosynthesis of aromatic grasses, and the identified candidate genes and markers can be a great resource for biotechnological and molecular breeding approaches to modulate the essential oil composition.

  15. De Novo Sequencing and Analysis of Lemongrass Transcriptome Provide First Insights into the Essential Oil Biosynthesis of Aromatic Grasses

    Science.gov (United States)

    Meena, Seema; Kumar, Sarma R.; Venkata Rao, D. K.; Dwivedi, Varun; Shilpashree, H. B.; Rastogi, Shubhra; Shasany, Ajit K.; Nagegowda, Dinesh A.

    2016-01-01

    Aromatic grasses of the genus Cymbopogon (Poaceae family) represent unique group of plants that produce diverse composition of monoterpene rich essential oils, which have great value in flavor, fragrance, cosmetic, and aromatherapy industries. Despite the commercial importance of these natural aromatic oils, their biosynthesis at the molecular level remains unexplored. As the first step toward understanding the essential oil biosynthesis, we performed de novo transcriptome assembly and analysis of C. flexuosus (lemongrass) by employing Illumina sequencing. Mining of transcriptome data and subsequent phylogenetic analysis led to identification of terpene synthases, pyrophosphatases, alcohol dehydrogenases, aldo-keto reductases, carotenoid cleavage dioxygenases, alcohol acetyltransferases, and aldehyde dehydrogenases, which are potentially involved in essential oil biosynthesis. Comparative essential oil profiling and mRNA expression analysis in three Cymbopogon species (C. flexuosus, aldehyde type; C. martinii, alcohol type; and C. winterianus, intermediate type) with varying essential oil composition indicated the involvement of identified candidate genes in the formation of alcohols, aldehydes, and acetates. Molecular modeling and docking further supported the role of identified protein sequences in aroma formation in Cymbopogon. Also, simple sequence repeats were found in the transcriptome with many linked to terpene pathway genes including the genes potentially involved in aroma biosynthesis. This work provides the first insights into the essential oil biosynthesis of aromatic grasses, and the identified candidate genes and markers can be a great resource for biotechnological and molecular breeding approaches to modulate the essential oil composition. PMID:27516768

  16. Medicare Provider Data - Hospice Providers

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Hospice Utilization and Payment Public Use File provides information on services provided to Medicare beneficiaries by hospice providers. The Hospice PUF...

  17. Influence of phonetic context on the dysphonic event: contribution of new methodologies for the analysis of pathological voice.

    Science.gov (United States)

    Revis, J; Galant, C; Fredouille, C; Ghio, A; Giovanni, A

    2012-01-01

    Widely studied in terms of perception, acoustics or aerodynamics, dysphonia stays nevertheless a speech phenomenon, closely related to the phonetic composition of the message conveyed by the voice. In this paper, we present a series of three works with the aim to understand the implications of the phonetic manifestation of dysphonia. Our first study proposes a new approach to the perceptual analysis of dysphonia (the phonetic labeling), which principle is to listen and evaluate each phoneme in a sentence separately. This study confirms the hypothesis of Laver that the dysphonia is not a constant noise added to the speech signal, but a discontinuous phenomenon, occurring on certain phonemes, based on the phonetic context. However, the burden of executing the task has led us to look to the techniques of automatic speaker recognition (ASR) to automate the procedure. With the collaboration of the LIA, we have developed a system for automatic classification of dysphonia from the techniques of ASR. This is the subject of our second study. The first results obtained with this system suggest that the unvoiced consonants show predominant performance in the task of automatic classification of dysphonia. This result is surprising since it is often assumed that dysphonia occurs only on laryngeal vibration. We started looking for explanations of this phenomenon and we present our assumptions and experiences in the third work we present.

  18. Contributions of social context to blood pressure: findings from a multilevel analysis of social capital and systolic blood pressure.

    Science.gov (United States)

    Hamano, Tsuyoshi; Fujisawa, Yoshikazu; Yamasaki, Masayuki; Ito, Katsuhisa; Nabika, Toru; Shiwaku, Kuninori

    2011-06-01

    In recent years, few studies have quantified the effect of residential context on blood pressure. Although these studies have emphasized the importance of socioeconomic influences such as education or poverty levels, the association between the features of social structure such as social capital and blood pressure remain unclear. Therefore, we investigated whether social capital was associated with systolic blood pressure after controlling for individual potential confounders. We analyzed data from the Shimane Study conducted from 2006 to 2008 in rural mountainous regions of Japan. After excluding the missing data and data of participants taking hypertension medication, we conducted a multilevel analysis of the data for 335 individuals nested within 30 postcode sectors. Systolic blood pressure increased with increasing age and body mass index. We also found that a higher systolic blood pressure was observed among smokers and those taking medication for diabetes. Regarding the contextual effects of social capital, systolic blood pressure increased with an increasing proportion of lack of fairness, after adjustment for individual confounders. To the best of our knowledge, this study is the first to investigate the association between social capital and systolic blood pressure by using a multilevel methodological framework. Surprisingly, we found that lack of fairness had a strong effect on systolic blood pressure. However, we could not find any significant associations between other items of social capital and systolic blood pressure. Further studies are needed to clarify the mechanism by which lack of fairness may have an effect on systolic blood pressure.

  19. Stigma in the context of schools: analysis of the phenomenon of stigma in a population of university students.

    Science.gov (United States)

    Pingani, Luca; Catellani, Sara; Del Vecchio, Valeria; Sampogna, Gaia; Ellefson, Sarah E; Rigatelli, Marco; Fiorillo, Andrea; Evans-Lacko, Sara; Corrigan, Patrick W

    2016-02-09

    Students have stereotyped views about people with mental illness. In particular, they believe that these persons are incurable, dangerous, unpredictable and responsible for their condition. This study aims to investigate the levels of public stigma in an Italian university population. The Attribution Questionnaire 27 - Italian Version (AQ-27-I) was administered to a sample of students from the Faculty of Medicine and Surgery of the University of Modena and Reggio Emilia. After examining the psychometric characteristics of the AQ-27-I (Cronbach's Alpha and Confirmatory Factor Analysis), multiple linear regression analyses were carried out to identify the predictors of stigmatizing attitudes in this population. Three hundred and eleven students completed the questionnaire, with a response rate of 32.81 % (out of the 948 contacted by email). The AQ-27-I showed good psychometric properties with an α = .68, and the fit indices of the models that partially supported the factor structure and paths. The two variables identified as possible predictors of stigmatizing attitudes (total score of AQ-27-I) were age and time spent reading newspapers. Antistigma campaigns are needed in university contexts, targeted in particular to students in health professions.

  20. A latent class growth analysis of school bullying and its social context: the self-determination theory perspective.

    Science.gov (United States)

    Lam, Shui-fong; Law, Wilbert; Chan, Chi-Keung; Wong, Bernard P H; Zhang, Xiao

    2015-03-01

    The contribution of social context to school bullying was examined from the self-determination theory perspective in this longitudinal study of 536 adolescents from 3 secondary schools in Hong Kong. Latent class growth analysis of the student-reported data at 5 time points from grade 7 to grade 9 identified 4 groups of students: bullies (9.8%), victims (3.0%), bully-victims (9.4%), and typical students (77.8%). There was a significant association between academic tracking and group membership. Students from the school with the lowest academic performance had a greater chance of being victims and bully-victims. Longitudinal data showed that all 4 groups tended to report less victimization over the years. The victims and the typical students also had a tendency to report less bullying over the years, but this tendency was reversed for bullies and bully-victims. Perceived support from teachers for relatedness significantly predicted membership of the groups of bullies and victims. Students with higher perceived support for relatedness from their teachers had a significantly lower likelihood of being bullies or victims. The findings have implications for the theory and practice of preventive interventions in school bullying.

  1. European business venturing in times of digitisation - An analysis of for-profit business incubators in a triple helix context

    DEFF Research Database (Denmark)

    Brem, Alexander; Kreusel, Nico; Roth, Natalie

    2018-01-01

    Business incubators have been developed as a key component of entrepreneurial activities in countries all over Europe. These incubators have a non-profit or a for-profit profile, with one-third located in Germany. The increased engagement of private business in what was a public-dominated incubat......Business incubators have been developed as a key component of entrepreneurial activities in countries all over Europe. These incubators have a non-profit or a for-profit profile, with one-third located in Germany. The increased engagement of private business in what was a public......-dominated incubation landscape may influence established theoretical frameworks. Within this context, this paper analyses 11 German business incubators to look at the most common types of for-profit business incubators in Germany and their main characteristics. Moreover, it introduces classification criteria...... for these incubators. Another aspect of the analysis is the effect of the triple helix dimensions of the different incubation types. The results show that two additional types of incubators can be identified in addition to the traditional public business incubator model, namely 'company builders' and 'accelerators...

  2. Interpreting the enigma of media-evangelist Joel Osteen: an analysis of his contexts, expressive theology and media use

    OpenAIRE

    Haire Jr., Earle Ross

    2017-01-01

    This thesis provides an analysis of one of the leading twenty-first century media-evangelists: Joel Osteen. His popularity is worldwide and has only increased over his seventeen years of ministry. His preaching and teachings enjoy sustained popularity resulting in book sales, internet downloads, radio listenership and television viewership in the millions. He has also created arguably the largest interracial congregation in the United States, boasting around 50,000 members, the...

  3. Analysis of Context Dependence in Social Interaction Networks of a Massively Multiplayer Online Role-Playing Game

    OpenAIRE

    Son, Seokshin; Kang, Ah Reum; Kim, Hyun-chul; Kwon, Taekyoung; Park, Juyong; Kim, Huy Kang

    2012-01-01

    Rapid advances in modern computing and information technology have enabled millions of people to interact online via various social network and gaming services. The widespread adoption of such online services have made possible analysis of large-scale archival data containing detailed human interactions, presenting a very promising opportunity to understand the rich and complex human behavior. In collaboration with a leading global provider of Massively Multiplayer Online Role-Playing Games (...

  4. Potentials and Limits of Secondary Analysis in a Specific Applied Context: The Case of EDF—Verbatim

    Directory of Open Access Journals (Sweden)

    Magdalini Dargentas

    2005-01-01

    Full Text Available In this paper we present the results of secondary analyses conducted on documents recorded in VERBATIM, the qualitative data archiving system and database developed by the Sociological Surveys Department (GRETS of Electricité de France (EDF. The archived studies, unique in France, offer some specific methodological and theoretical features. In order to explain their properties, constraints, and diversity we present four re-analysis studies, which provide an overview of the research aims and topics, the body of textual data, the methods of the secondary analysis and the conditions under which re-analysis can be judged as reliable. We also explore the use of qualitative software in these analyses. Furthermore, we focus on the Sociological Surveys Department researchers' attitudes towards secondary analysis, which shed light on the future development of secondary analysis in France. Finally, we present a future project concerning scientific collaboration with the Centre d'Informatisation des Données Socio-Politiques (CIDSP which aims to develop more systematic qualitative data archiving and secondary analysis in France. URN: urn:nbn:de:0114-fqs0501404

  5. The French wind energy market by 2020. Market evolution and competition context within the sector. Analysis of business model and of financial performance of fleet operators

    International Nuclear Information System (INIS)

    2016-01-01

    As the French wind energy sector has been recovering a good dynamics since 2014, notably for onshore production whereas some uncertainties remain present for offshore production, this report aims at assessing market perspectives by 2020, and at identifying business opportunities for the different involved actors. The first part identifies some determining factors for the sector activity, proposes an analysis of the activity for the 2002-2015 period (installed power, electricity production, turnover, equipment manufacturers, operators) and its perspectives by 2020 (evolution of determining factors, installed power, market share evolution for manufacturers, opportunities and threats on the medium term). The second part discusses the main elements of the operators' business models, and analyses fleet managers' financial data. Structural drivers and brakes are then discussed, as well as the French, European and World context (installed power, installed offshore power, electricity production, energy policy, law for energy transition, commitment of public authorities in favour of wind energy, competitiveness of wind energy). Some highlights and aspects of offer evolution are outlined: development of offshore wind energy, diversification of operators, international development, takeovers and capital increase, new financing modes. The last parts propose an analysis of the economic structure of the sector in France (types of interveners, staff, location, machine power evolution) and an overview of the main actors. Identity sheets of the main operators and equipment manufacturers are provided, as well as economic and financial data of 200 operators which can be compared through 5 key indicators

  6. Health and environmental risk governance in the french context. The role of scientific expertise and economic analysis

    International Nuclear Information System (INIS)

    Courvalin, C.; Boisson, P.; Dab, W.; Cohen de Lara, M.; Godard, O.; Heriard Dubreuil, G.; Hervouet, V.

    1998-01-01

    Full text of publication follows: increasing public concern as regards health and environmental risks makes it necessary, for public policies and regulation of risk assessment and management to comply with multiple and often non consistent expectations from the public in a rapidly changing environment. Evolution of risk assessment and management is currently observed as a consequence of this context. Whereas the former technical approaches were playing down the existence of residual risk as well as scientific uncertainties, current reflections rather aim at empowering the stakeholders of hazardous activities in the decision-making process in order to build up social trust and public confidence. This paper will present the conclusions of a work group entrusted by the French authorities with the task of proposing recommendations in order to update the risk assessment and management current approaches in the field of energy producing and consuming. The conclusions of this work are based on the analysis of three major issues as regards environmental health risks: climate change, atmospheric pollution, and radiation protection. It is also based on the 1997 report of the US Congress Commission on risk assessment and management. The report points out the difficulty for the French 'command and control' regulatory tradition to comply with public demand for transparency and more democratic involvement in the decision-making process. The conclusion presents various recommendations as regards the role of scientific expertise, the use of economic analysis and the decision-making process in risk assessment and management. The conclusion particularly emphasises key aspects of the decision-making process such as: the necessity of contextualizing risk assessment, the taking into account of scientific uncertainties and the need for stakeholders' involvement. (authors)

  7. Meta-analysis of changes in temperature and precipitation in Florida in the context of food-energy-water nexus

    Science.gov (United States)

    Anandhi, A.; Sharma, A.

    2017-12-01

    Florida is a hotspot of endemism for plants, vertebrates, and insects outside of the tropics. The state has extensive coastline, with the maximum distance from the coast less than 150 km which has diverse ecosystems and landscapes, as well as habitat for many endangered species. Additionally, agriculture is one of the most important economic resources in Florida and is ranked second in the U.S. for value of vegetable production. Florida's biodiversity is threatened by stressors such as increasing urbanization and population, land-use change and socio-economic growth. Given that, climate change and variability will interact with these stresses, potentially accentuating their negative impacts, there are several studies, concerning climate change impacts on Florida's ecosystem to date. The specific objectives of this study were to demonstrate the decision support tool developed from meta-analysis. The Tool was developed using the temperature and precipitation changes in Florida identified from peer reviewed studies. These change values were then synthesized using simple statistical techniques (e.g., histogram, line plots and density plots). Our results indicate a wide variability in the temperature and precipitation changes observed in the studies for Florida. The studies showed a temperature change ranged between +5 °C and -3 °C, while the precipitation change ranged between +30% and -40% in the state. These changes have series implications on the food-water-energy nexus. Some of the potential implications of these changes in the context of the nexus are discussed using causal chains developed from meta-analysis.

  8. What can management theories offer evidence-based practice? A comparative analysis of measurement tools for organisational context

    Science.gov (United States)

    French, Beverley; Thomas, Lois H; Baker, Paula; Burton, Christopher R; Pennington, Lindsay; Roddam, Hazel

    2009-01-01

    Background Given the current emphasis on networks as vehicles for innovation and change in health service delivery, the ability to conceptualise and measure organisational enablers for the social construction of knowledge merits attention. This study aimed to develop a composite tool to measure the organisational context for evidence-based practice (EBP) in healthcare. Methods A structured search of the major healthcare and management databases for measurement tools from four domains: research utilisation (RU), research activity (RA), knowledge management (KM), and organisational learning (OL). Included studies were reports of the development or use of measurement tools that included organisational factors. Tools were appraised for face and content validity, plus development and testing methods. Measurement tool items were extracted, merged across the four domains, and categorised within a constructed framework describing the absorptive and receptive capacities of organisations. Results Thirty measurement tools were identified and appraised. Eighteen tools from the four domains were selected for item extraction and analysis. The constructed framework consists of seven categories relating to three core organisational attributes of vision, leadership, and a learning culture, and four stages of knowledge need, acquisition of new knowledge, knowledge sharing, and knowledge use. Measurement tools from RA or RU domains had more items relating to the categories of leadership, and acquisition of new knowledge; while tools from KM or learning organisation domains had more items relating to vision, learning culture, knowledge need, and knowledge sharing. There was equal emphasis on knowledge use in the different domains. Conclusion If the translation of evidence into knowledge is viewed as socially mediated, tools to measure the organisational context of EBP in healthcare could be enhanced by consideration of related concepts from the organisational and management sciences

  9. What can management theories offer evidence-based practice? A comparative analysis of measurement tools for organisational context

    Directory of Open Access Journals (Sweden)

    Pennington Lindsay

    2009-05-01

    Full Text Available Abstract Background Given the current emphasis on networks as vehicles for innovation and change in health service delivery, the ability to conceptualise and measure organisational enablers for the social construction of knowledge merits attention. This study aimed to develop a composite tool to measure the organisational context for evidence-based practice (EBP in healthcare. Methods A structured search of the major healthcare and management databases for measurement tools from four domains: research utilisation (RU, research activity (RA, knowledge management (KM, and organisational learning (OL. Included studies were reports of the development or use of measurement tools that included organisational factors. Tools were appraised for face and content validity, plus development and testing methods. Measurement tool items were extracted, merged across the four domains, and categorised within a constructed framework describing the absorptive and receptive capacities of organisations. Results Thirty measurement tools were identified and appraised. Eighteen tools from the four domains were selected for item extraction and analysis. The constructed framework consists of seven categories relating to three core organisational attributes of vision, leadership, and a learning culture, and four stages of knowledge need, acquisition of new knowledge, knowledge sharing, and knowledge use. Measurement tools from RA or RU domains had more items relating to the categories of leadership, and acquisition of new knowledge; while tools from KM or learning organisation domains had more items relating to vision, learning culture, knowledge need, and knowledge sharing. There was equal emphasis on knowledge use in the different domains. Conclusion If the translation of evidence into knowledge is viewed as socially mediated, tools to measure the organisational context of EBP in healthcare could be enhanced by consideration of related concepts from the organisational

  10. What can management theories offer evidence-based practice? A comparative analysis of measurement tools for organisational context.

    Science.gov (United States)

    French, Beverley; Thomas, Lois H; Baker, Paula; Burton, Christopher R; Pennington, Lindsay; Roddam, Hazel

    2009-05-19

    Given the current emphasis on networks as vehicles for innovation and change in health service delivery, the ability to conceptualize and measure organisational enablers for the social construction of knowledge merits attention. This study aimed to develop a composite tool to measure the organisational context for evidence-based practice (EBP) in healthcare. A structured search of the major healthcare and management databases for measurement tools from four domains: research utilisation (RU), research activity (RA), knowledge management (KM), and organisational learning (OL). Included studies were reports of the development or use of measurement tools that included organisational factors. Tools were appraised for face and content validity, plus development and testing methods. Measurement tool items were extracted, merged across the four domains, and categorised within a constructed framework describing the absorptive and receptive capacities of organisations. Thirty measurement tools were identified and appraised. Eighteen tools from the four domains were selected for item extraction and analysis. The constructed framework consists of seven categories relating to three core organisational attributes of vision, leadership, and a learning culture, and four stages of knowledge need, acquisition of new knowledge, knowledge sharing, and knowledge use. Measurement tools from RA or RU domains had more items relating to the categories of leadership, and acquisition of new knowledge; while tools from KM or learning organisation domains had more items relating to vision, learning culture, knowledge need, and knowledge sharing. There was equal emphasis on knowledge use in the different domains. If the translation of evidence into knowledge is viewed as socially mediated, tools to measure the organisational context of EBP in healthcare could be enhanced by consideration of related concepts from the organisational and management sciences. Comparison of measurement tools across

  11. Variations in Medicare Reimbursement in Radiation Oncology: An Analysis of the Medicare Provider Utilization and Payment Data Set.

    Science.gov (United States)

    Vu, Charles C; Lanni, Thomas B; Robertson, John M

    2016-04-01

    The purposes of this study were to summarize recently published data on Medicare reimbursement to individual radiation oncologists and to identify the causes of variation in Medicare reimbursement in radiation oncology. The Medicare Provider Utilization and Payment Data: Physician and Other Supplier Public Use File (POSPUF), which details nearly all services provided by radiation oncologists in 2012, was used for this study. The data were filtered and analyzed by physician and by billing code. Statistical analysis was performed to identify differences in reimbursements based on sex, rurality, billing of technical services, or location in a certificate of need (CON) state. There were 4135 radiation oncologists who received a total of $1,499,625,803 in payments from Medicare in 2012. Seventy-five percent of radiation oncologists were male. The median reimbursement was $146,453. The code with the highest total reimbursement was 77418 (radiation treatment delivery intensity modulated radiation therapy [IMRT]). The most commonly billed evaluation and management (E/M) code for new visits was 99205 (49%). The most commonly billed E/M code for established visits was 99213 (54%). Forty percent of providers billed none of their new office visits using 99205 (the highest E/M billing code), whereas 34% of providers billed all of their new office visits using 99205. For the 1510 radiation oncologists (37%) who billed technical services, median Medicare reimbursement was $606,008, compared with $93,921 for all other radiation oncologists (Preimbursement. The billing of technical services, with their high capital and labor overhead requirements, limits any comparison in reimbursement between individual radiation oncologists or between radiation oncologists and other specialists. Male sex and rural practice location are independent predictors of higher total Medicare reimbursements. Copyright © 2016 Elsevier Inc. All rights reserved.

  12. A Descriptive Analysis of Care Provided by Law Enforcement Prior to EMS Arrival in the United States.

    Science.gov (United States)

    Klassen, Aaron B; Core, S Brent; Lohse, Christine M; Sztajnkrycer, Matthew D

    2018-04-01

    Study Objectives Law enforcement is increasingly viewed as a key component in the out-of-hospital chain of survival, with expanded roles in cardiac arrest, narcotic overdose, and traumatic bleeding. Little is known about the nature of care provided by law enforcement prior to the arrival of Emergency Medical Services (EMS) assets. The purpose of the current study was to perform a descriptive analysis of events reported to a national EMS database. This study was a descriptive analysis of the 2014 National Emergency Medical Services Information System (NEMSIS) public release research data set, containing EMS emergency response data from 41 states. Code E09_02 1200 specifically identifies care provided by law enforcement prior to EMS arrival. A total of 25,835,729 unique events were reported. Of events in which pre-arrival care was documented, 2.0% received prior aid by law enforcement. Patients receiving law enforcement care prior to EMS arrival were more likely to be younger (52.8 [SD=23.3] years versus 58.7 [SD=23.3] years), male (54.8% versus 46.7%), and white (80.3% versus 77.5%). Basic Life Support (BLS) EMS response was twice as likely in patients receiving prior aid by law enforcement. Multiple-casualty incidents were five times more likely with prior aid by law enforcement. Compared with prior aid by other services, law enforcement pre-arrival care was more likely with motor vehicle accidents, firearm assaults, knife assaults, blunt assaults, and drug overdoses, and less likely at falls and childbirths. Cardiac arrest was significantly more common in patients receiving prior aid by law enforcement (16.5% versus 2.6%). Tourniquet application and naloxone administration were more common in the law enforcement prior aid group. Where noted, law enforcement pre-arrival care occurs in 2.0% of EMS patient encounters. The majority of cases involve cardiac arrest, motor vehicle accidents, and assaults. Better understanding of the nature of law enforcement care is

  13. Treatment of childhood anxiety disorder in the context of maternal anxiety disorder: a randomised controlled trial and economic analysis.

    Science.gov (United States)

    Creswell, Cathy; Cruddace, Susan; Gerry, Stephen; Gitau, Rachel; McIntosh, Emma; Mollison, Jill; Murray, Lynne; Shafran, Rosamund; Stein, Alan; Violato, Mara; Voysey, Merryn; Willetts, Lucy; Williams, Nicola; Yu, Ly-Mee; Cooper, Peter J

    2015-05-01

    Cognitive-behavioural therapy (CBT) for childhood anxiety disorders is associated with modest outcomes in the context of parental anxiety disorder. This study evaluated whether or not the outcome of CBT for children with anxiety disorders in the context of maternal anxiety disorders is improved by the addition of (i) treatment of maternal anxiety disorders, or (ii) treatment focused on maternal responses. The incremental cost-effectiveness of the additional treatments was also evaluated. Participants were randomised to receive (i) child cognitive-behavioural therapy (CCBT); (ii) CCBT with CBT to target maternal anxiety disorders [CCBT + maternal cognitive-behavioural therapy (MCBT)]; or (iii) CCBT with an intervention to target mother-child interactions (MCIs) (CCBT + MCI). A NHS university clinic in Berkshire, UK. Two hundred and eleven children with a primary anxiety disorder, whose mothers also had an anxiety disorder. All families received eight sessions of individual CCBT. Mothers in the CCBT + MCBT arm also received eight sessions of CBT targeting their own anxiety disorders. Mothers in the MCI arm received 10 sessions targeting maternal parenting cognitions and behaviours. Non-specific interventions were delivered to balance groups for therapist contact. Primary clinical outcomes were the child's primary anxiety disorder status and degree of improvement at the end of treatment. Follow-up assessments were conducted at 6 and 12 months. Outcomes in the economic analyses were identified and measured using estimated quality-adjusted life-years (QALYs). QALYS were combined with treatment, health and social care costs and presented within an incremental cost-utility analysis framework with associated uncertainty. MCBT was associated with significant short-term improvement in maternal anxiety; however, after children had received CCBT, group differences were no longer apparent. CCBT + MCI was associated with a reduction in maternal overinvolvement

  14. MOTIVATIONAL CONTENT ANALYSIS OF PRIMARY SCHOOL TEXTBOOKS ON LITERATURE IN CONTEXT OF D. MCCLELLAND’S THEORY

    Directory of Open Access Journals (Sweden)

    E. V. Bataeva

    2018-01-01

    Full Text Available Introduction. The main motives of human behavior are formed at the primary school age. Several factors play a determining role in children’s development: up-bringing in the family, style of teaching at school, quality of popular literature and other sources of information, and, in particular, school textbooks. The special importance is given to the content quality of school textbooks. The influence of school textbooks is determined by the fact that school children should necessarily get familiar with the printed materials, resulting, as a consequence, in accepting the patterns of social interaction and motive-codes introduced there. Due to high constructivist potential of school textbooks, it seems necessary to carry out content analysis of textbooks’ for the purpose of identifying the influence on certain motive trends formation in schoolchildren.The aim of the publication is to present the methodology of motivational analysis of school textbooks on literature and the results of its approbation when studying the motivational content of Ukrainian textbooks for primary school.Methodology and research methods. The research methodology is based on comparative, socio-constructivist, sociocultural and system-activity approaches to implementation of educational process and preparation of didactic materials. Scientific methods involve: analysis and synthesis of the content of sociological, socio-psychological, pedagogical and methodical literature; content analysis of educational texts.Results and scientific novelty. The author’s methodology of motivational content analysis of primary school textbooks on literature developed in the context of D. McClelland’s theory is described. As the main categories of motivational content analysis of texts, the motives of behavior introduced by D. McClelland (achievements, affiliation, positive and negative power, avoidance of failure as well as the motives of self-expression and refusal of affiliation have

  15. DETECTION OF REPORTS FALSIFICATION PROVIDED TO A BANK BY A BORROWER USING THE METHOD OF DYNAMIC PARAMETERS ANALYSIS

    Directory of Open Access Journals (Sweden)

    M. S. Lyuft

    2015-01-01

    Full Text Available Summary. The main stop-factors in a landing were formed in the article according to the procedure of the European Bank for Reconstruction and Development by the means of questioning the leading Russian banks that finance small-scale business. It is given the description of this method, also it is identified the main weaknesses of the EBRD methodology. There is a description of the main methods of the borrowing company’s analytical balance and thereupon it is made the conclusion about the necessity of the analysis of the balance’s principal factors across time. The analysis of indicators and factors in the dynamics enables us to see trends in the development of the company, and to identify deviations in the coefficients. Either materiality or difference from normal values of these coefficients may indicate the factors of the borrowers’ misconduct, and in particular it gives evidence concerning falsification of reports provided to a bank. There are stages of information processing for falsification’s detection, excluding the interest from decision-makers about the possibility of lending in the results of a transaction. The formula that determinates the value of net profit falsification has been made on basis of dynamic parameters of the analytical balance and the connection with the administrative profit-and-loss report. Further, the article provides the second method of a determination of the net profit falsification already based on data of the parameters in dynamics namely business profitability rate. The process of calculation Payment To Income - payment to income - an indicator, in order to obtain good data on who falsify net income. Are key strengths of this method of identifying and conclusions paragraph article.

  16. Context matters!

    DEFF Research Database (Denmark)

    Bojesen, Anders

    2004-01-01

    for granted and unproblematic, although it is agreed to be of great importance. By crystallising three different modes of contextualised competence thinking (prescriptive, descriptive and analytical) the paper shows that the underlying assumptions about context - the interaction between the individual...... and the social - has major consequences for the specific enactment of competence. The paper argues in favour of a second order observation strategy for the context of competence. But in doing so it also shows that prevailing second-order competence theories so far, in criticising (counter) positions (and...

  17. Using semi-variogram analysis for providing spatially distributed information on soil surface condition for land surface modeling

    Science.gov (United States)

    Croft, Holly; Anderson, Karen; Kuhn, Nikolaus J.

    2010-05-01

    The ability to quantitatively and spatially assess soil surface roughness is important in geomorphology and land degradation studies. Soils can experience rapid structural degradation in response to land cover changes, resulting in increased susceptibility to erosion and a loss of Soil Organic Matter (SOM). Changes in soil surface condition can also alter sediment detachment, transport and deposition processes, infiltration rates and surface runoff characteristics. Deriving spatially distributed quantitative information on soil surface condition for inclusion in hydrological and soil erosion models is therefore paramount. However, due to the time and resources involved in using traditional field sampling techniques, there is a lack of spatially distributed information on soil surface condition. Laser techniques can provide data for a rapid three dimensional representation of the soil surface at a fine spatial resolution. This provides the ability to capture changes at the soil surface associated with aggregate breakdown, flow routing, erosion and sediment re-distribution. Semi-variogram analysis of the laser data can be used to represent spatial dependence within the dataset; providing information about the spatial character of soil surface structure. This experiment details the ability of semi-variogram analysis to spatially describe changes in soil surface condition. Soil for three soil types (silt, silt loam and silty clay) was sieved to produce aggregates between 1 mm and 16 mm in size and placed evenly in sample trays (25 x 20 x 2 cm). Soil samples for each soil type were exposed to five different durations of artificial rainfall, to produce progressively structurally degraded soil states. A calibrated laser profiling instrument was used to measure surface roughness over a central 10 x 10 cm plot of each soil state, at 2 mm sample spacing. The laser data were analysed within a geostatistical framework, where semi-variogram analysis quantitatively represented

  18. [Italian physician's needs for medical information. Retrospective analysis of the medical information service provided by Novartis Pharma to clinicians].

    Science.gov (United States)

    Speroni, Elisabetta; Poggi, Susanna; Vinaccia, Vincenza

    2013-10-01

    The physician's need for medical information updates has been studied extensively in recent years but the point of view of the pharmaceutical industry on this need has rarely been considered. This paper reports the results of a retrospective analysis of the medical information service provided to Italian physicians by an important pharmaceutical company, Novartis Pharma, from 2004 to 2012. The results confirm clinicians' appreciation of a service that gives them access to tailored scientific documentation and the number of requests made to the network of medical representatives has been rising steadily, peaking whenever new drugs become available to physicians. The analysis confirms what -other international studies have ascertained, that most queries are about how to use the drugs and what their properties are. The results highlight some differences between different medical specialties: for example, proportionally, neurologists seem to be the most curious. This, as well as other interesting snippets, is worth further exploration. Despite its limits in terms of representativeness, what comes out of the study is the existence of an real unmet need for information by healthcare institutions and that the support offered by the pharmaceutical industry could be invaluable; its role could go well beyond that of a mere supplier to National Healthcare Systems, to that of being recognised as an active partner the process of ensuring balanced and evidence-based information. At the same time, closer appraisal of clinicians' needs could help the pharma industries to improve their communication and educational strategies in presenting their latest clinical research and their own products.

  19. Fludarabine Melphalan reduced-intensity conditioning allotransplanation provides similar disease control in lymphoid and myeloid malignancies: analysis of 344 patients.

    Science.gov (United States)

    Bryant, A; Nivison-Smith, I; Pillai, E S; Kennedy, G; Kalff, A; Ritchie, D; George, B; Hertzberg, M; Patil, S; Spencer, A; Fay, K; Cannell, P; Berkahn, L; Doocey, R; Spearing, R; Moore, J

    2014-01-01

    This was an Australasian Bone Marrow Transplant Recipient Registry (ABMTRR)-based retrospective study assessing the outcome of Fludarabine Melphalan (FluMel) reduced-intensity conditioning between 1998 and 2008. Median follow-up was 3.4 years. There were 344 patients with a median age of 54 years (18-68). In all, 234 patients had myeloid malignancies, with AML (n=166) being the commonest indication. There were 110 lymphoid patients with non-hodgkins lymphoma (NHL) (n=64) the main indication. TRM at day 100 was 14% with no significant difference between the groups. OS and disease-free survival (DFS) were similar between myeloid and lymphoid patients (57 and 50% at 3 years, respectively). There was no difference in cumulative incidence of relapse or GVHD between groups. Multivariate analysis revealed four significant adverse risk factors for DFS: donor other than HLA-identical sibling donor, not in remission at transplant, previous autologous transplant and recipient CMV positive. Chronic GVHD was associated with improved DFS in multivariate analysis predominantly due to a marked reduction in relapse (HR:0.44, P=0.003). This study confirms that FluMel provides durable and equivalent remissions in both myeloid and lymphoid malignancies. Disease stage and chronic GVHD remain important determinants of outcome for FluMel allografting.

  20. Parallel experimental design and multivariate analysis provides efficient screening of cell culture media supplements to improve biosimilar product quality.

    Science.gov (United States)

    Brühlmann, David; Sokolov, Michael; Butté, Alessandro; Sauer, Markus; Hemberger, Jürgen; Souquet, Jonathan; Broly, Hervé; Jordan, Martin

    2017-07-01

    Rational and high-throughput optimization of mammalian cell culture media has a great potential to modulate recombinant protein product quality. We present a process design method based on parallel design-of-experiment (DoE) of CHO fed-batch cultures in 96-deepwell plates to modulate monoclonal antibody (mAb) glycosylation using medium supplements. To reduce the risk of losing valuable information in an intricate joint screening, 17 compounds were separated into five different groups, considering their mode of biological action. The concentration ranges of the medium supplements were defined according to information encountered in the literature and in-house experience. The screening experiments produced wide glycosylation pattern ranges. Multivariate analysis including principal component analysis and decision trees was used to select the best performing glycosylation modulators. Subsequent D-optimal quadratic design with four factors (three promising compounds and temperature shift) in shake tubes confirmed the outcome of the selection process and provided a solid basis for sequential process development at a larger scale. The glycosylation profile with respect to the specifications for biosimilarity was greatly improved in shake tube experiments: 75% of the conditions were equally close or closer to the specifications for biosimilarity than the best 25% in 96-deepwell plates. Biotechnol. Bioeng. 2017;114: 1448-1458. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  1. Characterization of Arabidopsis FPS isozymes and FPS gene expression analysis provide insight into the biosynthesis of isoprenoid precursors in seeds.

    Science.gov (United States)

    Keim, Verónica; Manzano, David; Fernández, Francisco J; Closa, Marta; Andrade, Paola; Caudepón, Daniel; Bortolotti, Cristina; Vega, M Cristina; Arró, Montserrat; Ferrer, Albert

    2012-01-01

    Arabidopsis thaliana contains two genes encoding farnesyl diphosphate (FPP) synthase (FPS), the prenyl diphoshate synthase that catalyzes the synthesis of FPP from isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). In this study, we provide evidence that the two Arabidopsis short FPS isozymes FPS1S and FPS2 localize to the cytosol. Both enzymes were expressed in E. coli, purified and biochemically characterized. Despite FPS1S and FPS2 share more than 90% amino acid sequence identity, FPS2 was found to be more efficient as a catalyst, more sensitive to the inhibitory effect of NaCl, and more resistant to thermal inactivation than FPS1S. Homology modelling for FPS1S and FPS2 and analysis of the amino acid differences between the two enzymes revealed an increase in surface polarity and a greater capacity to form surface salt bridges of FPS2 compared to FPS1S. These factors most likely account for the enhanced thermostability of FPS2. Expression analysis of FPS::GUS genes in seeds showed that FPS1 and FPS2 display complementary patterns of expression particularly at late stages of seed development, which suggests that Arabidopsis seeds have two spatially segregated sources of FPP. Functional complementation studies of the Arabidopsis fps2 knockout mutant seed phenotypes demonstrated that under normal conditions FPS1S and FPS2 are functionally interchangeable. A putative role for FPS2 in maintaining seed germination capacity under adverse environmental conditions is discussed.

  2. Comparative Proteomic Analysis of the Graft Unions in Hickory (Carya cathayensis Provides Insights into Response Mechanisms to Grafting Process

    Directory of Open Access Journals (Sweden)

    Daoliang Yan

    2017-04-01

    Full Text Available Hickory (Carya cathayensis, a tree with high nutritional and economic value, is widely cultivated in China. Grafting greatly reduces the juvenile phase length and makes the large scale cultivation of hickory possible. To reveal the response mechanisms of this species to grafting, we employed a proteomics-based approach to identify differentially expressed proteins in the graft unions during the grafting process. Our study identified 3723 proteins, of which 2518 were quantified. A total of 710 differentially expressed proteins (DEPs were quantified and these were involved in various molecular functional and biological processes. Among these DEPs, 341 were up-regulated and 369 were down-regulated at 7 days after grafting compared with the control. Four auxin-related proteins were down-regulated, which was in agreement with the transcription levels of their encoding genes. The Kyoto Encyclopedia of Genes and Genomes (KEGG analysis showed that the ‘Flavonoid biosynthesis’ pathway and ‘starch and sucrose metabolism’ were both significantly up-regulated. Interestingly, five flavonoid biosynthesis-related proteins, a flavanone 3-hyfroxylase, a cinnamate 4-hydroxylase, a dihydroflavonol-4-reductase, a chalcone synthase, and a chalcone isomerase, were significantly up-regulated. Further experiments verified a significant increase in the total flavonoid contents in scions, which suggests that graft union formation may activate flavonoid biosynthesis to increase the content of a series of downstream secondary metabolites. This comprehensive analysis provides fundamental information on the candidate proteins and secondary metabolism pathways involved in the grafting process for hickory.

  3. Characterization of Arabidopsis FPS isozymes and FPS gene expression analysis provide insight into the biosynthesis of isoprenoid precursors in seeds.

    Directory of Open Access Journals (Sweden)

    Verónica Keim

    Full Text Available Arabidopsis thaliana contains two genes encoding farnesyl diphosphate (FPP synthase (FPS, the prenyl diphoshate synthase that catalyzes the synthesis of FPP from isopentenyl diphosphate (IPP and dimethylallyl diphosphate (DMAPP. In this study, we provide evidence that the two Arabidopsis short FPS isozymes FPS1S and FPS2 localize to the cytosol. Both enzymes were expressed in E. coli, purified and biochemically characterized. Despite FPS1S and FPS2 share more than 90% amino acid sequence identity, FPS2 was found to be more efficient as a catalyst, more sensitive to the inhibitory effect of NaCl, and more resistant to thermal inactivation than FPS1S. Homology modelling for FPS1S and FPS2 and analysis of the amino acid differences between the two enzymes revealed an increase in surface polarity and a greater capacity to form surface salt bridges of FPS2 compared to FPS1S. These factors most likely account for the enhanced thermostability of FPS2. Expression analysis of FPS::GUS genes in seeds showed that FPS1 and FPS2 display complementary patterns of expression particularly at late stages of seed development, which suggests that Arabidopsis seeds have two spatially segregated sources of FPP. Functional complementation studies of the Arabidopsis fps2 knockout mutant seed phenotypes demonstrated that under normal conditions FPS1S and FPS2 are functionally interchangeable. A putative role for FPS2 in maintaining seed germination capacity under adverse environmental conditions is discussed.

  4. Does Articaine Provide an Advantage over Lidocaine in Patients with Symptomatic Irreversible Pulpitis? A Systematic Review and Meta-analysis.

    Science.gov (United States)

    Kung, Jason; McDonagh, Marian; Sedgley, Christine M

    2015-11-01

    Achieving profound pulpal anesthesia can be difficult in patients with symptomatic irreversible pulpitis. This study provides a systematic review and meta-analysis to address the population, intervention, comparison, outcome (PICO) question: in adults with symptomatic irreversible pulpitis who are undergoing endodontic treatment, what is the comparative efficacy of articaine compared with lidocaine in reducing pain and incidence of adverse events? A protocol was prepared and registered on PROSPERO. Electronic searches were conducted in MEDLINE, Scopus, Cochrane Library, and ClinicalTrials.gov by using strict inclusion and exclusion criteria. Two independent reviewers assessed eligibility for inclusion and quality. Weighted anesthesia success rates and 95% confidence intervals (CIs) were estimated and compared by using a random-effects model. Two hundred seventy-five studies were initially identified from the search; 10 double-blind, randomized clinical trials met the inclusion criteria. For combined studies, articaine was more likely than lidocaine to achieve successful anesthesia (odds ratio [OR], 2.21; 95% CI, 1.41-3.47; P = .0006; I(2) = 40%). Maxillary infiltration subgroup analysis showed no significant difference between articaine and lidocaine (OR, 3.99; 95% CI, 0.50-31.62; P = .19; I(2) = 59%). For combined mandibular anesthesia studies articaine was superior to lidocaine (OR, 2.20; 95% CI, 1.40-3.44; P = .0006; I(2) = 30%), with further subgroup analysis showing no difference for mandibular block anesthesia (OR, 1.44; 95% CI, 0.87-2.38; P = .16; I(2) = 0%). When used for supplemental infiltration after successful mandibular block anesthesia, articaine was significantly more effective than lidocaine (OR, 3.55; 95% CI, 1.97-6.39; P pulpitis. There is a significant advantage to using articaine over lidocaine for supplementary infiltration after mandibular block anesthesia but no advantage when used for mandibular block anesthesia alone or for maxillary

  5. The tempo and mode of New World monkey evolution and biogeography in the context of phylogenomic analysis.

    Science.gov (United States)

    Jameson Kiesling, Natalie M; Yi, Soojin V; Xu, Ke; Gianluca Sperone, F; Wildman, Derek E

    2015-01-01

    The development and evolution of organisms is heavily influenced by their environment. Thus, understanding the historical biogeography of taxa can provide insights into their evolutionary history, adaptations and trade-offs realized throughout time. In the present study we have taken a phylogenomic approach to infer New World monkey phylogeny, upon which we have reconstructed the biogeographic history of extant platyrrhines. In order to generate sufficient phylogenetic signal within the New World monkey clade, we carried out a large-scale phylogenetic analysis of approximately 40 kb of non-genic genomic DNA sequence in a 36 species subset of extant New World monkeys. Maximum parsimony, maximum likelihood and Bayesian inference analysis all converged on a single optimal tree topology. Divergence dating and biogeographic analysis reconstruct the timing and geographic location of divergence events. The ancestral area reconstruction describes the geographic locations of the last common ancestor of extant platyrrhines and provides insight into key biogeographic events occurring during platyrrhine diversification. Through these analyses we conclude that the diversification of the platyrrhines took place concurrently with the establishment and diversification of the Amazon rainforest. This suggests that an expanding rainforest environment rather than geographic isolation drove platyrrhine diversification. Copyright © 2014 Elsevier Inc. All rights reserved.

  6. Physical mapping and BAC-end sequence analysis provide initial insights into the flax (Linum usitatissimum L. genome

    Directory of Open Access Journals (Sweden)

    Cloutier Sylvie

    2011-05-01

    Full Text Available Abstract Background Flax (Linum usitatissimum L. is an important source of oil rich in omega-3 fatty acids, which have proven health benefits and utility as an industrial raw material. Flax seeds also contain lignans which are associated with reducing the risk of certain types of cancer. Its bast fibres have broad industrial applications. However, genomic tools needed for molecular breeding were non existent. Hence a project, Total Utilization Flax GENomics (TUFGEN was initiated. We report here the first genome-wide physical map of flax and the generation and analysis of BAC-end sequences (BES from 43,776 clones, providing initial insights into the genome. Results The physical map consists of 416 contigs spanning ~368 Mb, assembled from 32,025 fingerprints, representing roughly 54.5% to 99.4% of the estimated haploid genome (370-675 Mb. The N50 size of the contigs was estimated to be ~1,494 kb. The longest contig was ~5,562 kb comprising 437 clones. There were 96 contigs containing more than 100 clones. Approximately 54.6 Mb representing 8-14.8% of the genome was obtained from 80,337 BES. Annotation revealed that a large part of the genome consists of ribosomal DNA (~13.8%, followed by known transposable elements at 6.1%. Furthermore, ~7.4% of sequence was identified to harbour novel repeat elements. Homology searches against flax-ESTs and NCBI-ESTs suggested that ~5.6% of the transcriptome is unique to flax. A total of 4064 putative genomic SSRs were identified and are being developed as novel markers for their use in molecular breeding. Conclusion The first genome-wide physical map of flax constructed with BAC clones provides a framework for accessing target loci with economic importance for marker development and positional cloning. Analysis of the BES has provided insights into the uniqueness of the flax genome. Compared to other plant genomes, the proportion of rDNA was found to be very high whereas the proportion of known transposable

  7. Physical mapping and BAC-end sequence analysis provide initial insights into the flax (Linum usitatissimum L.) genome.

    Science.gov (United States)

    Ragupathy, Raja; Rathinavelu, Rajkumar; Cloutier, Sylvie

    2011-05-09

    Flax (Linum usitatissimum L.) is an important source of oil rich in omega-3 fatty acids, which have proven health benefits and utility as an industrial raw material. Flax seeds also contain lignans which are associated with reducing the risk of certain types of cancer. Its bast fibres have broad industrial applications. However, genomic tools needed for molecular breeding were non existent. Hence a project, Total Utilization Flax GENomics (TUFGEN) was initiated. We report here the first genome-wide physical map of flax and the generation and analysis of BAC-end sequences (BES) from 43,776 clones, providing initial insights into the genome. The physical map consists of 416 contigs spanning ~368 Mb, assembled from 32,025 fingerprints, representing roughly 54.5% to 99.4% of the estimated haploid genome (370-675 Mb). The N50 size of the contigs was estimated to be ~1,494 kb. The longest contig was ~5,562 kb comprising 437 clones. There were 96 contigs containing more than 100 clones. Approximately 54.6 Mb representing 8-14.8% of the genome was obtained from 80,337 BES. Annotation revealed that a large part of the genome consists of ribosomal DNA (~13.8%), followed by known transposable elements at 6.1%. Furthermore, ~7.4% of sequence was identified to harbour novel repeat elements. Homology searches against flax-ESTs and NCBI-ESTs suggested that ~5.6% of the transcriptome is unique to flax. A total of 4064 putative genomic SSRs were identified and are being developed as novel markers for their use in molecular breeding. The first genome-wide physical map of flax constructed with BAC clones provides a framework for accessing target loci with economic importance for marker development and positional cloning. Analysis of the BES has provided insights into the uniqueness of the flax genome. Compared to other plant genomes, the proportion of rDNA was found to be very high whereas the proportion of known transposable elements was low. The SSRs identified from BES will be

  8. Critical Analysis of the Quality, Readability, and Technical Aspects of Online Information Provided for Neck-Lifts.

    Science.gov (United States)

    Rayess, Hani; Zuliani, Giancarlo F; Gupta, Amar; Svider, Peter F; Folbe, Adam J; Eloy, Jean Anderson; Carron, Michael A

    2017-03-01

    The number of patients using the internet to obtain health information is growing. This material is unregulated and heterogeneous and can influence patient decisions. To compare the quality, readability, and technical aspects of online information about neck-lifts provided by private practice websites vs academic medical centers and reference sources. In this cross-sectional analysis conducted between November 2015 and January 2016, a Google search of the term neck-lift was performed, and the first 45 websites were evaluated. The websites were categorized as private practice vs other. Private websites (PWs) included sites created by private practice physicians. Other websites (OWs) were created by academic medical centers or reference sources. Quality, readability, and technical aspects of online websites related to neck-lifts. Quality was assessed using the DISCERN criteria and the Health on the Net principles (HONcode). Readability was assessed using 7 validated and widely used criteria. Consensus US reading grade level readability was provided by a website (readabilityformulas.com). Twelve technical aspects were evaluated based on criteria specified by medical website creators. Forty-five websites (8 OWs [18%] and 37 PWs [82%]) were analyzed. There was a significant difference in quality between OWs and PWs based on the DISCERN criteria and HONcode principles. The DISCERN overall mean (SD) scores were 2.3 (0.5) for OWs and 1.3 (0.3) for PWs (P analysis, the mean (SD) was 8.6 (1.8) (range, 5-11) for OW, and the mean (SD) was 5.8 (1.7) (range, 2-9) for PW. The mean (SD) readability consensus reading grade level scores were 11.7 (1.9) for OWs and 10.6 (1.9) for PWs. Of a total possible score of 12, the mean (SD) technical scores were 6.3 (1.8) (range, 4-9) for OWs and 6.4 (1.5) (range, 3-9) for PWs. Compared with PWs, OWs had a significantly higher quality score based on both the DISCERN criteria and HONcode principles. The mean readability for OWs and PWs was

  9. When Do Girls Prefer Football to Fashion? An Analysis of Female Underachievement in Relation to "Realistic" Mathematics Context.

    Science.gov (United States)

    Boaler, Jo

    1994-01-01

    Reports on a study of the move away from abstract calculations toward "mathematics in context" among 50 British female secondary school students. Discusses implications of findings in relation to reported female underachievement and disinterest in school mathematics. (CFR)

  10. Analysis of Factors Affecting Successful Clinical Trial Enrollment in the Context of Three Prospective, Randomized, Controlled Trials

    International Nuclear Information System (INIS)

    Logan, Jennifer K.; Tang, Chad; Liao, Zhongxing; Lee, J. Jack; Heymach, John V.; Swisher, Stephen G.; Welsh, James W.; Zhang, Jianjun; Lin, Steven H.; Gomez, Daniel R.

    2017-01-01

    Purpose: Challenges can arise when attempting to maximize patient enrollment in clinical trials. There have been limited studies focusing on the barriers to enrollment and the efficacy of alternative study design to improve accrual. We analyzed barriers to clinical trial enrollment, particularly the influence of timing, in context of three prospective, randomized oncology trials where one arm was considered more aggressive than the other. Methods and Materials: From June 2011 to March 2015, patients who were enrolled on 3 prospective institutional protocols (an oligometastatic non-small cell lung cancer [NSCLC] trial and 2 proton vs intensity modulated radiation therapy trials in NSCLC and esophageal cancer) were screened for protocol eligibility. Eligible candidates were approached about trial participation, and patient characteristics (age, sex, T/N categorization) were recorded along with details surrounding trial presentation (appointment number). Fisher's exact test, Student's t tests, and multivariate analysis were performed to assess differences between enrolled and refusal patients. Results: A total of 309 eligible patients were approached about trial enrollment. The enrollment success rate during this time span was 52% (n=160 patients). Enrolled patients were more likely to be presented trial information at an earlier appointment (oligometastatic protocol: 5 vs 3 appointments [P<.001]; NSCLC protocol: 4 vs 3 appointments [P=.0018]; esophageal protocol: 3 vs 2 appointments [P=.0086]). No other factors or patient characteristics significantly affected enrollment success rate. Conclusion: Improvement in enrollment rates for randomized control trials is possible, even in difficult accrual settings. Earlier presentation of trial information to patients is the most influential factor for success and may help overcome accrual barriers without compromising trial design.

  11. Analysis of Factors Affecting Successful Clinical Trial Enrollment in the Context of Three Prospective, Randomized, Controlled Trials

    Energy Technology Data Exchange (ETDEWEB)

    Logan, Jennifer K.; Tang, Chad; Liao, Zhongxing [Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States); Lee, J. Jack [Department of Biostatistics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States); Heymach, John V. [Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States); Swisher, Stephen G. [Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States); Welsh, James W. [Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States); Zhang, Jianjun [Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States); Lin, Steven H. [Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States); Gomez, Daniel R., E-mail: dgomez@mdanderson.org [Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States)

    2017-03-15

    Purpose: Challenges can arise when attempting to maximize patient enrollment in clinical trials. There have been limited studies focusing on the barriers to enrollment and the efficacy of alternative study design to improve accrual. We analyzed barriers to clinical trial enrollment, particularly the influence of timing, in context of three prospective, randomized oncology trials where one arm was considered more aggressive than the other. Methods and Materials: From June 2011 to March 2015, patients who were enrolled on 3 prospective institutional protocols (an oligometastatic non-small cell lung cancer [NSCLC] trial and 2 proton vs intensity modulated radiation therapy trials in NSCLC and esophageal cancer) were screened for protocol eligibility. Eligible candidates were approached about trial participation, and patient characteristics (age, sex, T/N categorization) were recorded along with details surrounding trial presentation (appointment number). Fisher's exact test, Student's t tests, and multivariate analysis were performed to assess differences between enrolled and refusal patients. Results: A total of 309 eligible patients were approached about trial enrollment. The enrollment success rate during this time span was 52% (n=160 patients). Enrolled patients were more likely to be presented trial information at an earlier appointment (oligometastatic protocol: 5 vs 3 appointments [P<.001]; NSCLC protocol: 4 vs 3 appointments [P=.0018]; esophageal protocol: 3 vs 2 appointments [P=.0086]). No other factors or patient characteristics significantly affected enrollment success rate. Conclusion: Improvement in enrollment rates for randomized control trials is possible, even in difficult accrual settings. Earlier presentation of trial information to patients is the most influential factor for success and may help overcome accrual barriers without compromising trial design.

  12. Discourse analysis and its uses in organizational studies: a study of quotation contexts of Phillips, Lawrence e Hardy (2004 [doi: 10.21529/RECADM.2016004

    Directory of Open Access Journals (Sweden)

    Samir Adamoglu de Oliveira

    2017-01-01

    Full Text Available This work has as goal to evaluate how the paper of Phillips, Lawrence and Hardy (2004 and their discourse analysis model has been appropriated in the Organizational Studies field. Using a bibliometric measure of quoters and the qualitative analysis of quotation context, this paper describes: (i the way it was applied empirically in researches, (ii to what study objects it was applied, (iii in which thematic areas it was used, and (iv its repercussion among different theoretical slopes that have used the analytical model. As it was one of the first works to consider the possibility of a discourse analysis within the organizational studies using institutionalism, after 10 years of the publication, the results show perennial as a meta-theoretical base to discuss the theme. Considering those, the present paper proposes a theoretical-methodological model to conduct future discussions about the discourse role in the (reproduction of institutional web.   Keywords Discourse analysis; Discourse; Institutions; Quotation contexts.

  13. Contexts as Shared Commitments

    Directory of Open Access Journals (Sweden)

    Manuel eGarcía-Carpintero

    2015-12-01

    Full Text Available Contemporary semantics assumes two different notions of context: one coming from Kaplan (1989, on which contexts are sets of predetermined parameters, and another originated in Stalnaker (1978, on which contexts are sets of propositions that are common ground. The latter is deservedly more popular, given its flexibility to account for context-dependent aspects of language beyond manifest indexicals, such as epistemic modals, predicates of taste, and so on and so forth; in fact, properly dealing with demonstratives (perhaps ultimately all indexicals requires that further flexibility. Even if we acknowledge Lewis (1980 point that, in a sense, Kaplanian contexts already include common ground contexts, it is better to be clear and explicit about what contexts constitutively are. Now, Stalnaker (1978, 2002, 2014 defines context-as-common-ground as a set of propositions, but recent work shows that this is not an accurate conception. The paper explains why, and provides an alternative. The main reason is that several phenomena (presuppositional treatments of pejoratives and predicates of taste, forces other than assertion require that the common ground includes non-doxastic attitudes such as appraisals, emotions, etc. Hence the common ground should not be taken to include merely contents (propositions, but those together with attitudes concerning them: shared commitments, as I will defend.

  14. Can the EVIDEM Framework Tackle Issues Raised by Evaluating Treatments for Rare Diseases: Analysis of Issues and Policies, and Context-Specific Adaptation.

    Science.gov (United States)

    Wagner, Monika; Khoury, Hanane; Willet, Jacob; Rindress, Donna; Goetghebeur, Mireille

    2016-03-01

    The multiplicity of issues, including uncertainty and ethical dilemmas, and policies involved in appraising interventions for rare diseases suggests that multicriteria decision analysis (MCDA) based on a holistic definition of value is uniquely suited for this purpose. The objective of this study was to analyze and further develop a comprehensive MCDA framework (EVIDEM) to address rare disease issues and policies, while maintaining its applicability across disease areas. Specific issues and policies for rare diseases were identified through literature review. Ethical and methodological foundations of the EVIDEM framework v3.0 were systematically analyzed from the perspective of these issues, and policies and modifications of the framework were performed accordingly to ensure their integration. Analysis showed that the framework integrates ethical dilemmas and issues inherent to appraising interventions for rare diseases but required further integration of specific aspects. Modification thus included the addition of subcriteria to further differentiate disease severity, disease-specific treatment outcomes, and economic consequences of interventions for rare diseases. Scoring scales were further developed to include negative scales for all comparative criteria. A methodology was established to incorporate context-specific population priorities and policies, such as those for rare diseases, into the quantitative part of the framework. This design allows making more explicit trade-offs between competing ethical positions of fairness (prioritization of those who are worst off), the goal of benefiting as many people as possible, the imperative to help, and wise use of knowledge and resources. It also allows addressing variability in institutional policies regarding prioritization of specific disease areas, in addition to existing uncertainty analysis available from EVIDEM. The adapted framework measures value in its widest sense, while being responsive to rare disease

  15. Extending the Global Sensitivity Analysis of the SimSphere model in the Context of its Future Exploitation by the Scientific Community

    Directory of Open Access Journals (Sweden)

    George P. Petropoulos

    2015-05-01

    Full Text Available In today’s changing climate, the development of robust, accurate and globally applicable models is imperative for a wider understanding of Earth’s terrestrial biosphere. Moreover, an understanding of the representation, sensitivity and coherence of such models are vital for the operationalisation of any physically based model. A Global Sensitivity Analysis (GSA was conducted on the SimSphere land biosphere model in which a meta-modelling method adopting Bayesian theory was implemented. Initially, effects of assuming uniform probability distribution functions (PDFs for the model inputs, when examining sensitivity of key quantities simulated by SimSphere at different output times, were examined. The development of topographic model input parameters (e.g., slope, aspect, and elevation were derived within a Geographic Information System (GIS before implementation within the model. The effect of time of the simulation on the sensitivity of previously examined outputs was also analysed. Results showed that simulated outputs were significantly influenced by changes in topographic input parameters, fractional vegetation cover, vegetation height and surface moisture availability in agreement with previous studies. Time of model output simulation had a significant influence on the absolute values of the output variance decomposition, but it did not seem to change the relative importance of each input parameter. Sensitivity Analysis (SA results of the newly modelled outputs allowed identification of the most responsive model inputs and interactions. Our study presents an important step forward in SimSphere verification given the increasing interest in its use both as an independent modelling and educational tool. Furthermore, this study is very timely given on-going efforts towards the development of operational products based on the synergy of SimSphere with Earth Observation (EO data. In this context, results also provide additional support for the

  16. CONTEXT 2015 Doctorial Symposium

    DEFF Research Database (Denmark)

    Eklund, Peter; wegener, rebekah

    2015-01-01

    What is the CONTEXT 2015 Doctoral Symposium? The CONTEXT 2015 Doctoral Symposium is an opportunity for doctoral researchers to showcase their work and discuss problems, challenges, and ideas in an open and collegial environment with expert feedback. The Doctoral Symposium is a workshop for doctoral...... feedback and general advice in a constructive atmosphere. Doctoral researchers will present and discuss their research in a supportive atmosphere with other doctoral researchers and an international panel of established researchers that provide expert feedback. The workshop will take place on a single full...... day, Monday November 2, 2015, the day prior to the start of the main CONTEXT 2015 conference....

  17. Measuring School Contexts

    Directory of Open Access Journals (Sweden)

    Chandra L. Muller PhD

    2015-11-01

    Full Text Available This article describes issues in measuring school contexts with an eye toward understanding students’ experiences and outcomes. I begin with an overview of the conceptual underpinnings related to measuring contexts, briefly describe the initiatives at the National Center for Education Statistics to measure school contexts, and identify possible gaps in those initiatives that if filled could provide valuable new data for researchers. Next, I discuss new approaches and opportunities for measurement, and special considerations related to diverse populations and youth development. I conclude with recommendations for future priorities.

  18. [Cost analysis of radiotherapy provided in inpatient setting -  testing potential predictors for a new prospective payment system].

    Science.gov (United States)

    Sedo, J; Bláha, M; Pavlík, T; Klika, P; Dušek, L; Büchler, T; Abrahámová, J; Srámek, V; Slampa, P; Komínek, L; Pospíšil, P; Sláma, O; Vyzula, R

    2014-01-01

    As a part of the development of a new prospective payment model for radiotherapy we analyzed data on costs of care provided by three comprehensive cancer centers in the Czech Republic. Our aim was to find a combination of variables (predictors) which could be used to sort hospitalization cases into groups according to their costs, with each group having the same reimbursement rate. We tested four variables as possible predictors -  number of fractions, stage of disease, radiotherapy technique and diagnostic group. We analyzed 7,440 hospitalization cases treated in three comprehensive cancer centers from 2007 to 2011. We acquired data from the I COP database developed by Institute of Biostatistics and Analyses of Masaryk University in cooperation with oncology centers that contains records from the National Oncological Registry along with data supplied by healthcare providers to insurance companies for the purpose of retrospective reimbursement. When comparing the four variables mentioned above we found that number of fractions and radiotherapy technique were much stronger predictors than the other two variables. Stage of disease did not prove to be a relevant indicator of cost distinction. There were significant differences in costs among diagnostic groups but these were mostly driven by the technique of radiotherapy and the number of fractions. Within the diagnostic groups, the distribution of costs was too heterogeneous for the purpose of the new payment model. The combination of number of fractions and radiotherapy technique appears to be the most appropriate cost predictors to be involved in the prospective payment model proposal. Further analysis is planned to test the predictive value of intention of radiotherapy in order to determine differences in costs between palliative and curative treatment.

  19. Analysis of the Genetic Diversity and Population Structure of Austrian and Belgian Wheat Germplasm within a Regional Context Based on DArT Markers

    Directory of Open Access Journals (Sweden)

    Mohamed A. El-Esawi

    2018-01-01

    Full Text Available Analysis of crop genetic diversity and structure provides valuable information needed to broaden the narrow genetic base as well as to enhance the breeding and conservation strategies of crops. In this study, 95 Austrian and Belgian wheat cultivars maintained at the Centre for Genetic Resources (CGN in the Netherlands were characterised using 1052 diversity array technology (DArT markers to evaluate their genetic diversity, relationships and population structure. The rarefacted allelic richness recorded in the Austrian and Belgian breeding pools (A25 = 1.396 and 1.341, respectively indicated that the Austrian germplasm contained a higher genetic diversity than the Belgian pool. The expected heterozygosity (HE values of the Austrian and Belgian pools were 0.411 and 0.375, respectively. Moreover, the values of the polymorphic information content (PIC of the Austrian and Belgian pools were 0.337 and 0.298, respectively. Neighbour-joining tree divided each of the Austrian and Belgian germplasm pools into two genetically distinct groups. The structure analyses of the Austrian and Belgian pools were in a complete concordance with their neighbour-joining trees. Furthermore, the 95 cultivars were compared to 618 wheat genotypes from nine European countries based on a total of 141 common DArT markers in order to place the Austrian and Belgian wheat germplasm in a wider European context. The rarefacted allelic richness (A10 varied from 1.224 (Denmark to 1.397 (Austria. Cluster and principal coordinates (PCoA analyses divided the wheat genotypes of the nine European countries into two main clusters. The first cluster comprised the Northern and Western European wheat genotypes, whereas the second included the Central European cultivars. The structure analysis of the 618 European wheat genotypes was in a complete concordance with the results of cluster and PCoA analyses. Interestingly, a highly significant difference was recorded between regions (26.53%. In

  20. Imagined in Policy, Inscribed on Bodies: Defending an Ethic of Compassion in a Political Context; Comment on “Why and How Is Compassion Necessary to Provide Good Quality Healthcare?”

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    Dave Mercer

    2015-10-01

    Full Text Available In response to the International Journal of Health Policy and Management (IJHPMeditorial, this commentary adds to the debate about ethical dimensions of compassionate care in UK service provision. It acknowledges the importance of the original paper, and attempts to explore some of the issues that are raised in the context of nursing practice, research and education. It is argued that each of these fields of the profession are enacted in an escalating culture of corporatism, be that National Health Service (NHS or university campus, and global neoliberalism. Post-structuralist ideas, notably those of Foucault, are borrowed to interrogate healthcare as discursive practice and disciplinary knowledge; where an understanding of the ways in which power and language operate is prominent. Historical and contemporary evidence of institutional and ideological degradation of sections of humanity, a ‘history of the present,’ serve as reminders of the import, and fragility, of ethical codes.

  1. Analysis of ecological context for identifying vegetation and animal conservation planning foci: An example from the arid South-western USA

    Science.gov (United States)

    Hamazaki, T.; Thompson, B.C.; Locke, B.A.; Boykin, K.G.

    2003-01-01

    In developing conservation strategies, it is important to maximize effects of conservation within a specified land tract and to maximize conservation effects on surrounding area (ecological context). The authors proposed two criteria to select biotic entities for conservation foci: (1) the relative occurrence of fauna or flora in a tract is greater than that of an ecological context region; and (2) occurrence of the fauna or flora is relatively limited in the ecological context region. Using extensive spatial data on vegetation and wildlife habitat distribution, the authors identified strategic vegetation and fauna conservation foci for the 400 000 ha Fort Bliss military reservation in New Mexico and Texas relative to a 164 km radius ecological context region intersecting seven ecological zones and the predicted habitat distribution of 616 animal species. The authors set two specific criteria: (1) predicted area of a species' occurrence is 5% (Fort Bliss is 4.2% of the region). These criteria selected one vegetation class and 40 animal species. Further, these vegetation and animal foci were primarily located in two areas of Fort Bliss. Sensitivity analyses with other analytical radii corroborated the context radius used. Conservation of the two areas and associated taxa will maximize the contribution of Fort Bliss's conservation efforts in its ecological proximity. This relatively simple but information-rich process represents economical and defensible preliminary contextual analysis for detailed conservation planning.

  2. AN ANALYSIS OF CONTEXT-AWARE DATA MODELS FOR SMART CITIES: TOWARDS FIWARE AND ETSI CIM EMERGING DATA MODEL

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    A. J. Jara

    2017-09-01

    Full Text Available Smart Cities requires the support of context-aware and enriched semantic descriptions to support a scalable and cross-domain development of smart applications. For example, nowadays general purpose sensors such as crowd monitoring (counting people in an area, environmental information (pollution, air quality, temperature, humidity, noise etc. can be used in multiple solutions with different objectives. For that reason, a data model that offers advanced capabilities for the description of context is required. This paper presents an overview of the available technologies for this purpose and how it is being addressed by the Open and Agile Smart Cities principles and FIWARE platform through the data models defined by the ETSI ISG Context Information Management (ETSI CIM.

  3. An Analysis of Context-Aware Data Models for Smart Cities: Towards Fiware and Etsi Cim Emerging Data Model

    Science.gov (United States)

    Jara, A. J.; Bocchi, Y.; Fernandez, D.; Molina, G.; Gomez, A.

    2017-09-01

    Smart Cities requires the support of context-aware and enriched semantic descriptions to support a scalable and cross-domain development of smart applications. For example, nowadays general purpose sensors such as crowd monitoring (counting people in an area), environmental information (pollution, air quality, temperature, humidity, noise) etc. can be used in multiple solutions with different objectives. For that reason, a data model that offers advanced capabilities for the description of context is required. This paper presents an overview of the available technologies for this purpose and how it is being addressed by the Open and Agile Smart Cities principles and FIWARE platform through the data models defined by the ETSI ISG Context Information Management (ETSI CIM).

  4. Effect of cervical cancer education and provider recommendation for screening on screening rates: A systematic review and meta-analysis.

    Directory of Open Access Journals (Sweden)

    Jonah Musa

    Full Text Available Although cervical cancer is largely preventable through screening, detection and treatment of precancerous abnormalities, it remains one of the top causes of cancer-related morbidity and mortality globally.The objective of this systematic review is to understand the evidence of the effect of cervical cancer education compared to control conditions on cervical cancer screening rates in eligible women population at risk of cervical cancer. We also sought to understand the effect of provider recommendations for screening to eligible women on cervical cancer screening (CCS rates compared to control conditions in eligible women population at risk of cervical cancer.We used the PICO (Problem or Population, Interventions, Comparison and Outcome framework as described in the Cochrane Collaboration Handbook to develop our search strategy. The details of our search strategy has been described in our systematic review protocol published in the International Prospective Register of systematic reviews (PROSPERO. The protocol registration number is CRD42016045605 available at: http://www.crd.york.ac.uk/prospero/display_record.asp?src=trip&ID=CRD42016045605. The search string was used in Pubmed, Embase, Cochrane Systematic Reviews and Cochrane CENTRAL register of controlled trials to retrieve study reports that were screened for inclusion in this review. Our data synthesis and reporting was guided by the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA. We did a qualitative synthesis of evidence and, where appropriate, individual study effects were pooled in meta-analyses using RevMan 5.3 Review Manager. The Higgins I2 was used to assess for heterogeneity in studies pooled together for overall summary effects. We did assessment of risk of bias of individual studies included and assessed risk of publication bias across studies pooled together in meta-analysis by Funnel plot.Out of 3072 study reports screened, 28 articles were found to

  5. Beyond physical access: a qualitative analysis into the barriers to policy implementation and service provision experienced by persons with disabilities living in a rural context.

    Science.gov (United States)

    Neille, Joanne; Penn, Claire

    2015-01-01

    Persons with disabilities make up approximately 15% of the world's population, with vulnerable communities disproportionately affected by the incidence of disability. Research reflects that persons with disabilities are vulnerable to stigma and discrimination, social isolation, and have physical barriers to accessing support services, all of which serve to perpetuate a sense of uncertainty and vulnerability within their lives. Recently a number of policies and models of intervention have been introduced intended to protect the rights of those affected by disability, yet limited research has been conducted into the lived experiences of persons with disabilities, particularly in rural contexts. This implies that little is known about the impact of the rural context on the lived experience of disability and the ways in which context impacts on the implementation of policies and practices. The current study employed a qualitative design underpinned by the principles of narrative inquiry and participant observation. Thirty adults with a variety of congenital and acquired disabilities (15 men and 15 women, ranging in age from 19 to 83 years) living in 12 rural communities in the Mpumalanga Province of South Africa were recruited through snowball sampling. Data collection comprised a combination of narrative inquiry and participant observation. Narratives were collected in SiSwati with the assistance of a SiSwati-speaking research mediator and were transcribed and translated into English. Data were analysed inductively according to the principles of thematic analysis. Findings confirmed that the experience of living with a disability in a rural area is associated with discrimination, social exclusion, and isolation and barriers to accessing services, underpinned by numerous context-specific experiences, including mortality rates, exposure to numerous and repeated forms of violence across the lifespan, and corruption and lack of transparency in the implementation of

  6. Exploring rape myths, gendered norms, group processing, and the social context of rape among college women: a qualitative analysis.

    Science.gov (United States)

    Deming, Michelle E; Covan, Eleanor Krassen; Swan, Suzanne C; Billings, Deborah L

    2013-04-01

    The purpose of this research is to explore the negotiation strategies of college women as they interpret ambiguous rape scenarios. In focus groups, 1st- and 4th-year college women were presented with a series of three vignettes depicting incidents that meet the legal criteria for rape yet are ambiguous due to the presence of cultural rape myths, contexts involving alcohol consumption, varying degrees of consent, and a known perpetrator. These contexts are critical in understanding how college women define rape. Key findings indicated many of these college women utilized rape myths and norms within their peer groups to interpret rape scenarios.

  7. Analysis of 14C and 13C in teeth provides precise birth dating and clues to geographical origin.

    Science.gov (United States)

    Alkass, K; Buchholz, B A; Druid, H; Spalding, K L

    2011-06-15

    average δ(13)C (-14.8) than teeth from subjects raised in Japan (-13.5), Middle East and North Africa (-12.7) and South America (-10.9). In summary, isotopic analysis of carbon in enamel from a single tooth can give a good estimate of the year of birth of an individual and also provide information about the geographical origin of the individual. This