WorldWideScience

Sample records for analysis latest advances

  1. Latest Advances in Robot Kinematics

    CERN Document Server

    Husty, Manfred

    2012-01-01

    This book is  of interest to researchers inquiring about modern topics and methods in the kinematics, control and design of robotic manipulators. It considers the full range of robotic systems, including serial, parallel and cable driven manipulators, both planar and spatial. The systems range from being less than fully mobile to kinematically redundant to overconstrained. In addition to recognized areas, this book also presents recent advances in emerging areas such as the design and control of humanoids and humanoid subsystems, and the analysis, modeling and simulation of human body motions, as well as the mobility analysis of protein molecules and the development of machines which incorporate man.

  2. Editorial: Latest methods and advances in biotechnology.

    Science.gov (United States)

    Lee, Sang Yup; Jungbauer, Alois

    2014-01-01

    The latest "Biotech Methods and Advances" special issue of Biotechnology Journal continues the BTJ tradition of featuring the latest breakthroughs in biotechnology. The special issue is edited by our Editors-in-Chief, Prof. Sang Yup Lee and Prof. Alois Jungbauer and covers a wide array of topics in biotechnology, including the perennial favorite workhorses of the biotech industry, Chinese hamster ovary (CHO) cell and Escherichia coli.

  3. [Latest advances of SLA class I genes].

    Science.gov (United States)

    Tao, Xuan; Li, Hua; Li, Xue-Wei; Yu, Hui; Zuo, Qi-Zhen

    2007-11-01

    The Swine leukocyte antigen (SLA) class I genes encode multi-glycoproteins on cell surface, which present endogenous antigenic peptides to T cells and thus initiate specific immune responses. In this article, latest advances on molecular structure, expression in tissues, regulation of expression, genotyping, polymorphism, and evolution of SLA class I genes were introduced, in which genotyping and polymorphism were emphasized. Molecular typing methods of SLA class I genes include serological method, DNA sequencing, PCR-SSP, PCR-SSOP and MS, of which PCR-SSP is frequently used in genotyping of SLA class I genes as a simple and rapid method. Future directions for the study and application of SLA class I genes on gene functions, peptide vaccine, xenotransplantation were also discussed.

  4. Latest Trends in Finite Element Analysis

    Directory of Open Access Journals (Sweden)

    L. S. Madhav

    1996-01-01

    Full Text Available This paper highlights the advances in computer graphics and the computational power of the processors which have promoted a method of analysis, applicable to almost all the fields of engineering. The advantages of the computers have been judiciously used in the design of algorithms, based on the principles of finite difference, finite element, boundary element, etc., intended for the analysis of engineering components. The concept of finite element method which has been generalised with the availability of commercial software, is also reviewed with a special emphasis on the future trends. The modelling and visualisation techniques have also been discussed with an inner perspective on future of visual display of multidimensional complex information. The application of these techniques in some fields is also indicated.

  5. Latest Advances Towards Ras Inhibition: A Medicinal Chemistry Perspective.

    Science.gov (United States)

    Sautier, Brice; Nising, Carl F; Wortmann, Lars

    2016-12-23

    Owing to their high occurrence rate across many human cancers and their lack of druggability so far, mutant forms of the signaling protein Ras are currently among the most attractive (and elusive) oncology targets. This strong appeal explains the sustained effort in the field, and the ensuing progress has rekindled optimism regarding the discovery of Ras inhibitors. In this Minireview, we discuss the most recent advances towards irreversible inhibitors, and highlight approaches to inhibitors of Ras-effector interactions that have been overshadowed by the current focus on direct Ras inhibition. At the same time, we provide a critical assessment from a medicinal chemistry perspective.

  6. Highlights of the Latest Advances in Research on CDK Inhibitors

    Directory of Open Access Journals (Sweden)

    Jonas Cicenas

    2014-10-01

    Full Text Available Uncontrolled proliferation is the hallmark of cancer and other proliferative disorders and abnormal cell cycle regulation is, therefore, common in these diseases. Cyclin-dependent kinases (CDKs play a crucial role in the control of the cell cycle and proliferation. These kinases are frequently deregulated in various cancers, viral infections, neurodegenerative diseases, ischemia and some proliferative disorders. This led to a rigorous pursuit for small-molecule CDK inhibitors for therapeutic uses. Early efforts to block CDKs with nonselective CDK inhibitors led to little specificity and efficacy but apparent toxicity, but the recent advance of selective CDK inhibitors allowed the first successful efforts to target these kinases for the therapies of several diseases. Major ongoing efforts are to develop CDK inhibitors as monotherapies and rational combinations with chemotherapy and other targeted drugs.

  7. Latest nH analysis in the Double Chooz experiment

    CERN Document Server

    Yang, Guang

    2015-01-01

    Precise measurement of the neutrino mixing angle $\\theta_{13}$ is the primary goal of the Double Chooz Experiment (DC), which is located in Chooz, France. The inverse beta decay process provides a unique signature of reactor anti-neutrino interactions, giving prompt signals from positron annihilation and delayed signals from neutron capture by either Gadolinium (Gd) or Hydrogen (H). This paper is dedicated to the latest nH analysis in Double Chooz. Typically, The Gd analysis is primary since fewer background events are involved. However, with accurate estimates of backgrounds and a precise reconstruction of energy, the nH analysis gives a powerful independent measurement of $\\theta_{13}$.

  8. Handbook of Advanced Multilevel Analysis

    CERN Document Server

    Hox, Joop

    2010-01-01

    This new handbook is the definitive resource on advanced topics related to multilevel analysis. The editors have assembled the top minds in the field to address the latest applications of multilevel modeling as well as the specific difficulties and methodological problems that are becoming more common as more complicated models are developed.

  9. Advanced Analysis of Nontraditional Machining

    CERN Document Server

    Tsai, Hung-Yin

    2013-01-01

    Nontraditional machining utilizes thermal, chemical, electrical, mechanical and optical sources of energy to form and cut materials. Advanced Analysis of Nontraditional Machining explains in-depth how each of these advanced machining processes work, their machining system components, and process variables and industrial applications, thereby offering advanced knowledge and scientific insight. This book also documents the latest and frequently cited research results of a few key nonconventional machining processes for the most concerned topics in industrial applications, such as laser machining, electrical discharge machining, electropolishing of die and mold, and wafer processing for integrated circuit manufacturing. This book also: Fills the gap of the advanced knowledge of nonconventional machining between industry and research Documents latest and frequently cited research of key nonconventional machining processes for the most sought after topics in industrial applications Demonstrates advanced multidisci...

  10. The latest advances of experimental research on targeted gene therapy for prostate cancer

    Institute of Scientific and Technical Information of China (English)

    Dongliang Pan; Lianchao Jin; Xianghua Zhang

    2013-01-01

    The absence of ef ective therapies for castration-resistant prostate cancer (CRPC) establishes the need to de-velop novel therapeutic modality, such as targeted gene therapy, which is ideal for the treatment of CRPC. But its application has been limited due to lack of favorable gene vector and the reduction of“bystander ef ect”. Consequently, scientists al over the world focus their main experimental research on the fol owing four aspects:targeted gene, vector, transfer means and comprehensive therapy. In this paper, we reviewed the latest advances of experimental research on targeted gene therapy for prostate cancer .

  11. How gamma radiation processing systems are benefiting from the latest advances in information technology

    Science.gov (United States)

    Gibson, Wayne H.; Levesque, Daniel

    2000-03-01

    This paper discusses how gamma irradiation plants are putting the latest advances in computer and information technology to use for better process control, cost savings, and strategic advantages. Some irradiator operations are gaining significant benefits by integrating computer technology and robotics with real-time information processing, multi-user databases, and communication networks. The paper reports on several irradiation facilities that are making good use of client/server LANs, user-friendly graphics interfaces, supervisory control and data acquisition (SCADA) systems, distributed I/O with real-time sensor devices, trending analysis, real-time product tracking, dynamic product scheduling, and automated dosimetry reading. These plants are lowering costs by fast and reliable reconciliation of dosimetry data, easier validation to GMP requirements, optimizing production flow, and faster release of sterilized products to market. There is a trend in the manufacturing sector towards total automation using "predictive process control". Real-time verification of process parameters "on-the-run" allows control parameters to be adjusted appropriately, before the process strays out of limits. Applying this technology to the gamma radiation process, control will be based on monitoring the key parameters such as time, and making adjustments during the process to optimize quality and throughput. Dosimetry results will be used as a quality control measurement rather than as a final monitor for the release of the product. Results are correlated with the irradiation process data to quickly and confidently reconcile variations. Ultimately, a parametric process control system utilizing responsive control, feedback and verification will not only increase productivity and process efficiency, but can also result in operating within tighter dose control set points.

  12. The FOXSI sounding rocket: Latest analysis and results

    Science.gov (United States)

    Camilo Buitrago-Casas, Juan; Glesener, Lindsay; Christe, Steven; Krucker, Sam; Ishikawa, Shin-Nosuke; Takahashi, Tadayuki; Ramsey, Brian; Han, Raymond

    2016-05-01

    Hard X-ray (HXR) observations are a linchpin for studying particle acceleration and hot thermal plasma emission in the solar corona. Current and past indirectly imaging instruments lack the sensitivity and dynamic range needed to observe faint HXR signatures, especially in the presences of brighter sources. These limitations are overcome by using HXR direct focusing optics coupled with semiconductor detectors. The Focusing Optics X-ray Solar Imager (FOXSI) sounding rocket experiment is a state of the art solar telescope that develops and applies these capabilities.The FOXSI sounding rocket has successfully flown twice, observing active regions, microflares, and areas of the quiet-Sun. Thanks to its far superior imaging dynamic range, FOXSI performs cleaner hard X-ray imaging spectroscopy than previous instruments that use indirect imaging methods like RHESSI.We present a description of the FOXSI rocket payload, paying attention to the optics and semiconductor detectors calibrations, as well as the upgrades made for the second flight. We also introduce some of the latest FOXSI data analysis, including imaging spectroscopy of microflares and active regions observed during the two flights, and the differential emission measure distribution of the nonflaring corona.

  13. Latest advancements in fluorescence hyperspectral lidar imaging of the cultural heritage

    Science.gov (United States)

    Raimondi, V.; Conti, C.; Lognoli, D.; Palombi, L.

    2013-11-01

    Fluorescence lidar imaging can be regarded as an effective tool for early diagnostics and documentation of the outdoor cultural heritage, with the aim of a correct planning of conservation and restoration of monuments. In this paper we present the latest advancements on fluorescence hyperspectral lidar imaging recently achieved at IFAC-CNR in terms of instrumentation and novel applications. In particular, the paper focuses on the upgrading of some key technical features, such as: the scan speed of the sensor, spatial resolution at the surface and field of view of the instrument. The upgrading of these technical characteristics has also made it possible to successfully extend the applicability of the technique to the diagnostics on wall paintings, which requires an improved spatial resolution. Finally, we outline the potential of a new concept of fluorescence lidar imaging system, based on the integration of hyperspectral and fluorescence lifetime spectroscopy, which enhances the capabilities of the technique for the characterization of the materials to be investigated in cultural heritage assets.

  14. Latest developments in advanced network management and cross-sharing of next-generation flux stations

    Science.gov (United States)

    Burba, George; Johnson, Dave; Velgersdyk, Michael; Begashaw, Israel; Allyn, Douglas

    2016-04-01

    In recent years, spatial and temporal flux data coverage improved significantly and on multiple scales, from a single station to continental networks, due to standardization, automation, and management of the data collection, and better handling of the extensive amounts of generated data. However, operating budgets for flux research items, such as labor, travel, and hardware, are becoming more difficult to acquire and sustain. With more stations and networks, larger data flows from each station, and smaller operating budgets, modern tools are required to effectively and efficiently handle the entire process, including sharing data among collaborative groups. On one hand, such tools can maximize time dedicated to publications answering research questions, and minimize time and expenses spent on data acquisition, processing, quality control and overall station management. On the other hand, cross-sharing the stations with external collaborators may help leverage available funding, and promote data analyses and publications. A new low-cost, advanced system, FluxSuite, utilizes a combination of hardware, software and web-services to address these specific demands. It automates key stages of flux workflow, minimizes day-to-day site management, and modernizes the handling of data flows: (i) The system can be easily incorporated into a new flux station, or as un upgrade to many presently operating flux stations, via weatherized remotely-accessible microcomputer, SmartFlux 2, with fully digital inputs (ii) Each next-generation station will measure all parameters needed for flux computations in a digital and PTP time-synchronized mode, accepting digital signals from a number of anemometers and data loggers (iii) The field microcomputer will calculate final fully-processed flux rates in real time, including computation-intensive Fourier transforms, spectra, co-spectra, multiple rotations, stationarity, footprint, etc. (iv) Final fluxes, radiation, weather and soil data will

  15. Latest developments on safety analysis methodologies at the Juzbado plant

    Energy Technology Data Exchange (ETDEWEB)

    Zurron-Cifuentes, Oscar; Ortiz-Trujillo, Diego; Blanco-Fernandez, Luis A. [ENUSA Industrias Avanzadas S. A., Juzbado Nuclear Fuel Fabrication Plant, Ctra. Salamanca-Ledesma, km. 26, 37015 Juzbado, Salamanca (Spain)

    2010-07-01

    Over the last few years the Juzbado Plant has developed and implemented several analysis methodologies to cope with specific issues regarding safety management. This paper describes the three most outstanding of them, so as to say, the Integrated Safety Analysis (ISA) project, the adaptation of the MARSSIM methodology for characterization surveys of radioactive contamination spots, and the programme for the Systematic Review of the Operational Conditions of the Safety Systems (SROCSS). Several reasons motivated the decision to implement such methodologies, such as Regulator requirements, operational experience and of course, the strong commitment of ENUSA to maintain the highest standards of nuclear industry on all the safety relevant activities. In this context, since 2004 ENUSA is undertaking the ISA project, which consists on a systematic examination of plant's processes, equipment, structures and personnel activities to ensure that all relevant hazards that could result in unacceptable consequences have been adequately evaluated and the appropriate protective measures have been identified. On the other hand and within the framework of a current programme to ensure the absence of radioactive contamination spots on unintended areas, the MARSSIM methodology is being applied as a tool to conduct the radiation surveys and investigation of potentially contaminated areas. Finally, the SROCSS programme was initiated earlier this year 2009 to assess the actual operating conditions of all the systems with safety relevance, aiming to identify either potential non-conformities or areas for improvement in order to ensure their high performance after years of operation. The following paragraphs describe the key points related to these three methodologies as well as an outline of the results obtained so far. (authors)

  16. Hedgehog pathway inhibition in advanced basal cell carcinoma: latest evidence and clinical usefulness

    Science.gov (United States)

    Silapunt, Sirunya; Chen, Leon; Migden, Michael R.

    2016-01-01

    Treatment of locally advanced basal cell carcinomas (laBCCs) with large, aggressive, destructive, and disfiguring tumors, or metastatic disease is challenging. Dysregulation of the Hedgehog (Hh) signaling pathway has been identified in the vast majority of basal cell carcinomas (BCCs). There are two United States Food and Drug Administration (US FDA)-approved Hh pathway inhibitors (HPIs) that exhibit antitumor activity in advanced BCC with an acceptable safety profile. Common adverse effects include muscle spasms, dysgeusia, alopecia, fatigue, nausea and weight loss. PMID:27583029

  17. Latest advances in confocal microscopy of skin cancers toward guiding patient care: a Mohs surgeon's review and perspective (Conference Presentation)

    Science.gov (United States)

    Nehal, Kishwer S.; Rajadhyaksha, Milind

    2016-02-01

    Latest advances in confocal microscopy of skin cancers toward guiding patient care: a Mohs surgeon's review and perspective About 350 publications worldwide have reported the ability of reflectance confocal microscopy (RCM) imaging to detect melanocytic skin lesions in vivo with specificity of 84-88% and sensitivity of 71-92%, and non-melanocytic skin lesions with specificity of 85-97% and sensitivity 100-92%. Lentigo maligna melanoma can be detected with sensitivity of 93% and specificity 82%. While the sensitivity is comparable to that of dermoscopy, the specificity is 2X superior, especially for lightly- and non-pigmented lesions. Dermoscopy combined with RCM imaging is proving to be both highly sensitive and highly specific. Recent studies have reported that the ratio of equivocal (i.e., would have been biopsied) lesions to detected melanomas dropped by ~2X when guided by dermoscopy and RCM imaging, compared to that with dermoscopy alone. Dermoscopy combined with RCM imaging is now being implemented to guide noninvasive diagnosis (to rule out malignancy and biopsy) and to also guide treatment, with promising initial impact: thus far, about 3,000 patients have been saved from biopsies of benign lesions. These are currently under follow-up monitoring. With fluorescence confocal microscopy (FCM) mosaicing, residual basal cell carcinomas can be detected in Mohs surgically excised fresh tissue ex vivo, with sensitivity of 94-97% and specificity 89-94%. FCM mosaicing is now being implemented for guiding Mohs surgery. To date, about 600 Mohs procedures have been performed, guided with mosaicing, and with pathology being performed in parallel to confirm the final outcome. These latest advances demonstrate the promising ability of RCM and FCM to guide patient care.

  18. Latest Pleistocene advance and collapse of the Matanuska - Knik glacier system, Anchorage Lowland, southern Alaska

    Science.gov (United States)

    Kopczynski, Sarah E.; Kelley, Samuel E.; Lowell, Thomas V.; Evenson, Edward B.; Applegate, Patrick J.

    2017-01-01

    At the end of the last ice age, glacier systems worldwide underwent dramatic retreat. Here, we document the advance and retreat of a glacier system with adjacent marine- and land-based components during the latter part of the Termination. We utilize three lines of evidence: lithologic provenance, geomorphic mapping, and radiocarbon ages derived from lake cores to reconstruct glacier extent and timing of advance and retreat within our study area centered at N 61.50°, W 149.50°, just north of Anchorage, Alaska. Two glaciers, sourced in the Talkeetna and Chugach Mountains, flowed down the Matanuska and Knik Valleys forming a coalesced lobe that advanced onto the Anchorage Lowlands and terminated at Elmendorf Moraine. We use the presence of lithologies unique to the Matanuska catchment in glacial drift to delineate the paleoflow lines and to estimate the suture line of the two glacier systems. The eastern side of the lobe, attributed to ice flow from the Knik Valley, was in contact with elevated marine waters within the Knik Arm fjord, and thus retreat was likely dominated by calving. Geomorphic evidence suggests the western side of the lobe, attributed to ice flow from Matanuska Valley, retreated due to stagnation. We constrain retreat of the combined Matanuska and Knik lobe with thirteen new radiocarbon ages, in addition to previously published radiocarbon ages, and with geomorphic evidence suggesting the retreat occurred in two phases. Retreat from the Elmendorf Moraine began between 16.8 and 16.4 ka BP. A second, faster retreat phase occurred later and was completed by 13.7 ka BP. With the 140 km of total retreat occurring over ∼3000 years or less. This pattern of glacial advance and retreats agrees well with the deglacial histories from the southern sectors of the Cordilleran Ice Sheet, as well as many other alpine glacier systems in the western U.S. and northern Alaska. This consistent behavior of glacier systems may indicate that climate oscillated over

  19. Management of Gliomas: Overview of the Latest Technological Advancements and Related Behavioral Drawbacks

    Directory of Open Access Journals (Sweden)

    L. Ganau

    2015-01-01

    Full Text Available The advancements in basic sciences and the availability of sophisticated technological aids to surgical removal of gliomas have led over the last few years to the rise of innovative surgical strategies, the identification of better prognostic/predictive biomolecular factors, and the development of novel drugs and all are meant to profoundly impact the outcome of patients diagnosed with these aggressive tumours. Unfortunately, the treatment protocols available nowadays still confer only a small survival advantage at a potentially high cost in terms of overall well-being. In this review we identified the potential and limits of the most promising research trends in the management of glioma patients, also highlighting the related externalities. Finally, we focused our attention on the imbalance between the technical and behavioral aspects pertinent to this research area, which ultimately represent the two sides of the same coin.

  20. Management of Gliomas: Overview of the Latest Technological Advancements and Related Behavioral Drawbacks.

    Science.gov (United States)

    Ganau, L; Paris, M; Ligarotti, G K; Ganau, M

    2015-01-01

    The advancements in basic sciences and the availability of sophisticated technological aids to surgical removal of gliomas have led over the last few years to the rise of innovative surgical strategies, the identification of better prognostic/predictive biomolecular factors, and the development of novel drugs and all are meant to profoundly impact the outcome of patients diagnosed with these aggressive tumours. Unfortunately, the treatment protocols available nowadays still confer only a small survival advantage at a potentially high cost in terms of overall well-being. In this review we identified the potential and limits of the most promising research trends in the management of glioma patients, also highlighting the related externalities. Finally, we focused our attention on the imbalance between the technical and behavioral aspects pertinent to this research area, which ultimately represent the two sides of the same coin.

  1. Development of Ideas About Holocene and Latest Pleistocene Glacier Advances in the North American Cordillera

    Science.gov (United States)

    Osborn, G.

    2014-12-01

    It all started when Francois Matthes coined the phrase "little ice age" (LIA) in 1939 to explain cirque moraines in the Sierra Nevada. Porter and Denton in the late 60's promoted the concept that the LIA was part of a multi-millennium regrowth of glaciers called "Neoglaciation."A second set of small moraines found in a few cirques short distances downvalley of LIA moraines in the American Rockies began attracting some attention in the 1940s-50s. By the 1960s-70s there was much argument over the age(s) of these moraines. A proliferation of ages appeared in the literature in the 1970s-80s, but Thom Davis and Jerry Osborn in 1987 proposed that most or all these outer cirque moraines are actually Younger Dryas (YD) in age.In Alberta in the 1970s, Brian Luckman began studying LIA deposits and Osborn began mapping outer cirque moraines (Crowfoot moraines). The two joined forces for an overview of Holocene glacial history in the Canadian Rockies in 1979.Eric Leonard and Mel Reasoner began lake-sediment studies in the Canadian Rockies in the 1980s-90s. Reasoner and Osborn concluded using lake sediments that the type Crowfoot moraine is YD in age, and in Colorado and Wyoming, Davis, Reasoner, and Brian Menounos established YD ages of outer cirque moraines. Lateral-moraine stratigraphy, begun in the 1980s by June Ryder and Osborn in British Columbia, corroborated the evidence from lake sediments that minor advances and retreats punctuated a gradual Neoglacial expansion of glaciers that began 7 or 8 ka.The era of cosmogenic dating began in the 1990s, with John Gosse's work in the Wind River Range. Most, but not all, cosmogenic ages on outer cirque moraines, including those yielded by Shaun Marcott's broad survey, are in support of the concept that such moraines are YD or pre-YD in age, although uncertainties resulting from production-rate questions remain. There have been various claims of early Holocene advances greater in magnitude than the LIA, but these have been

  2. Latest advances in edema

    Science.gov (United States)

    Villavicencio, J. L.; Hargens, A. R.; Pikoulicz, E.

    1996-01-01

    Basic concepts in the physiopathology of edema are reviewed. The mechanisms of fluid exchange across the capillary endothelium are explained. Interstitial flow and lymph formation are examined. Clinical disorders of tissue and lymphatic transport, microcirculatory derangements in venous disorders, protein disorders, and lymphatic system disorders are explored. Techniques for investigational imaging of the lymphatic system are explained.

  3. Latest development in seismic texture analysis for subsurface structure, facies, and reservoir characterization: A review

    Energy Technology Data Exchange (ETDEWEB)

    Gao, Dengliang

    2011-03-01

    In exploration geology and geophysics, seismic texture is still a developing concept that has not been sufficiently known, although quite a number of different algorithms have been published in the literature. This paper provides a review of the seismic texture concepts and methodologies, focusing on latest developments in seismic amplitude texture analysis, with particular reference to the gray level co-occurrence matrix (GLCM) and the texture model regression (TMR) methods. The GLCM method evaluates spatial arrangements of amplitude samples within an analysis window using a matrix (a two-dimensional histogram) of amplitude co-occurrence. The matrix is then transformed into a suite of texture attributes, such as homogeneity, contrast, and randomness, which provide the basis for seismic facies classification. The TMR method uses a texture model as reference to discriminate among seismic features based on a linear, least-squares regression analysis between the model and the data within an analysis window. By implementing customized texture model schemes, the TMR algorithm has the flexibility to characterize subsurface geology for different purposes. A texture model with a constant phase is effective at enhancing the visibility of seismic structural fabrics, a texture model with a variable phase is helpful for visualizing seismic facies, and a texture model with variable amplitude, frequency, and size is instrumental in calibrating seismic to reservoir properties. Preliminary test case studies in the very recent past have indicated that the latest developments in seismic texture analysis have added to the existing amplitude interpretation theories and methodologies. These and future developments in seismic texture theory and methodologies will hopefully lead to a better understanding of the geologic implications of the seismic texture concept and to an improved geologic interpretation of reflection seismic amplitude

  4. Latest research related to climate change analysis with applications in impact studies over the territory of Serbia

    Science.gov (United States)

    Vukovic, Ana; Vujadinovic, Mirjam; Djurdjevic, Vladimir; Cvetkovic, Bojan; Djordjevic, Marija; Ruml, Mirjana; Rankovic-Vasic, Zorica; Przic, Zoran; Stojicic, Djurdja; Krzic, Aleksandra; Rajkovic, Borivoj

    2015-04-01

    Serbia is a country with relatively small scale terrain features with economy mostly based on local landowners' agricultural production. Climate change analysis must be downscaled accordingly, to recognize climatological features of the farmlands. Climate model simulations and impact studies significantly contribute to the future strategic planning in economic development and therefore impact analysis must be approached with high level of confidence. This paper includes research related to climate change and impacts in Serbia resulted from cooperative work of the modeling and user community. Dynamical downscaling of climate projections for the 21st century with multi-model approach and statistical bias correction are done in order to prepare model results for impact studies. Presented results are from simulations performed using regional EBU-POM model, which is forced with A1B and A2 SRES/IPCC (2007) with comparative analysis with other regional models and from the latest high resolution NMMB simulations forced with RCP8.5 IPCC scenario (2012). Application of bias correction of the model results is necessary when calculated indices are not linearly dependent on the model results and delta approach in presenting results with respect to present climate simulations is insufficient. This is most important during the summer over the north part of the country where model bias produce much higher temperatures and less precipitation, which is known as "summer drying problem" and is common in regional models' simulations over the Pannonian valley. Some of the results, which are already observed in present climate, like higher temperatures and disturbance in the precipitation pattern, lead to present and future advancement of the start of the vegetation period toward earlier dates, associated with an increased risk of the late spring frost, extended vegetation period, disturbed preparation for the rest period, increased duration and frequency of the draught periods, etc

  5. Advanced Economic Analysis

    Science.gov (United States)

    Greenberg, Marc W.; Laing, William

    2013-01-01

    An Economic Analysis (EA) is a systematic approach to the problem of choosing the best method of allocating scarce resources to achieve a given objective. An EA helps guide decisions on the "worth" of pursuing an action that departs from status quo ... an EA is the crux of decision-support.

  6. Advancements in Micrometeorological Technique for Monitoring CH4 Release from Remote Permafrost Regions: Principles, Emerging Research, and Latest Updates

    Science.gov (United States)

    Burba, George; Budishchev, Artem; Gioli, Beniamino; Haapanala, Sami; Helbig, Manuel; Losacco, Salvatore; Mammarella, Ivan; Moreaux, Virginie; Murphy, Patrick; Oechel, Walter; Peltola, Olli; Rinne, Janne; Sonnentag, Oliver; Sturtevant, Cove; Vesala, Timo; Zona, Donatella; Zulueta, Rommel

    2014-05-01

    in permafrost regions have mostly been made with static chamber techniques, and few were done with the eddy covariance approach using closed-path analyzers. Although chambers and closed-path analyzers have advantages, both techniques have significant limitations, especially for remote or portable research in cold regions. Static chamber measurements are discrete in time and space, and particularly difficult to use over polygonal tundra with highly non-uniform micro-topography and active soil layer. Closed-path gas analyzers for measuring CH4 eddy fluxes require climate control, employ high-power pumps, and generally require grid power and infrastructure. As a result, spatial coverage of eddy covariance CH4 flux measurements in cold regions remains limited. Existing stations are often located near grid power sources and roads rather than in the middle of the methane-producing ecosystem, while those that are placed appropriately may require extraordinary efforts to build and maintain them, with large investments into manpower and infrastructure. In this presentation, basic principles of eddy covariance flux measurements are explained, along with details on the CH4, CO2 and H2O exchange measurements using low-power flux stations. Also included are latest updates on the emerging research utilizing such stations in remote permafrost regions, and on the 2013-2014 development of fully automated remote unattended flux station capable of processing data on-the-go to continuously output final CH4 release rates.

  7. Suicide among young people in Spain: Facts and possible causes. An analysis of latest data available

    Directory of Open Access Journals (Sweden)

    Noelia Navarro-Gómez

    2017-03-01

    Full Text Available Suicide is the third leading cause of death in the age group between 15 to 29 years, surpassed only by external causes of death and tumors according to the National Institute of Statistics. The latest data available shows that 310 children and young people under 30 took their own lives, which represents 7.77% of all suicide victims. This article aims to extensively describe the state of the art from the data available in the literature, based on the overview worldwide. The causes that can lead to such acts are discussed, indicating the presence of psychological disorders, specific personality variables, the high burden of emotional stress or bullying, lately displaced by new variants such as cyberbullying or sexting.

  8. The Latest Fashion Trends

    Institute of Scientific and Technical Information of China (English)

    1997-01-01

    Twice each year Chinese designers reveal the latest fashion trends. Working together with mills and garment enterprises, riley turn the study and prediction of prevailing styles into the driving force for the fashion industry’s development. Different clothing manufacturers may understand and make use of such trend analysis according to the specific kinds of garments they produce, one of the important elements in today’s garment production.

  9. Fly ash: Analysis and characterization. (Latest citations from the EI Compendex*plus database). Published Search

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-08-01

    The bibliography contains citations concerning the analysis and characterization of fly ash. Topics cover x-ray classification, trace analysis, particle size distribution, ash morphology, surface adsorption, toxicity, and mutagenic fly ash. Fluidized-bed-combustion technology for coal-combustion systems to meet air-emission standards is examined. The use of fly ash in concrete and cement manufacturing is discussed. (Contains 50-250 citations and includes a subject term index and title list.) (Copyright NERAC, Inc. 1995)

  10. Fly ash: Analysis and characterization. (Latest citations from the EI Compendex*plus database). Published Search

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-05-01

    The bibliography contains citations concerning the analysis and characterization of fly ash. Topics cover x-ray classification, trace analysis, particle size distribution, ash morphology, surface adsorption, toxicity, and mutagenic fly ash. Fluidized-bed-combustion technology for coal-combustion systems to meet air-emission standards is examined. The use of fly ash in concrete and cement manufacturing is discussed. (Contains 50-250 citations and includes a subject term index and title list.) (Copyright NERAC, Inc. 1995)

  11. 形状记忆基聚合物复合材料的研究进展%The Latest Advances in Shape Memory Composites

    Institute of Scientific and Technical Information of China (English)

    王坤; 朱光明

    2012-01-01

    Shape memory polymer(SMP) is a novel intelligent material, which is widely used in the field of medical and aerospace. However, due to low mechanical strength, small deformation recovery stress and etc. , the development and application of the traditional SMP have been restricted. In order to improve the properties of the SMP, particle or fiber reinforced composites based on shape memory polymer are developed. The latest advances in shape memory composites are reviewed, and the relationship between the shape memory effect and the mechanical properties of the SMP composites and the volume fraction or weight fraction of the fillers are described. Finally, the application field and the development prospects of the shape memory composites are introduced.%形状记忆聚合物是一种新型智能材料,广泛应用于医疗和航天领域.但是传统的形状记忆聚合物由于力学强度低、形变回复力小等缺点使其发展应用受到限制.主要介绍了以各种形状记忆聚合物为基体,添加增强填料来制备形状记忆聚合物复合材料,并且描述了复合材料的形状记忆效应与力学性能和填料的体积分数或质量分数之间的关系,以及形状记忆聚合物复合材料的应用领域与前景.

  12. Oil pollution sampling, detection, and analysis. (Latest citations from the NTIS bibliographic database). Published Search

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-05-01

    The bibliography contains citations concerning the monitoring and analysis of pollution resulting from oil production and transport operations. Citations discuss pollution monitoring methods and devices, tracing and analytical techniques, remote sensing, and oil-laden sediment sampling. Marine pollution assessment and control, offshore oil industry discharges, pollution effects on wildlife, and international cooperation on pollution control are also examined. (Contains 50-250 citations and includes a subject term index and title list.) (Copyright NERAC, Inc. 1995)

  13. Water pollution analysis and detection. (Latest citations from the NTIS bibliographic database). Published Search

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-08-01

    The bibliography contains citations concerning water pollution analysis, detection, monitoring, and regulation. Citations review online systems, bioassay monitoring, laser-based detection, sensor and biosensor systems, metabolic analyzers, and microsystem techniques. References cover fiber-optic portable detection instruments and rapid detection of toxicants in drinking water. (Contains 50-250 citations and includes a subject term index and title list.) (Copyright NERAC, Inc. 1995)

  14. Statistically improved Analysis of Neutrino Oscillation Data with the latest KamLAND result

    CERN Document Server

    Aliani, P; Torrente-Lujan, E

    2005-01-01

    We present an updated analysis of all available solar and reactor neutrino data, emphasizing in particular the totality of the KamLAND (314d live time) results and including for the first time the solar $SNO$ (391d live time, phase II NaCl-enhanced) spectrum data. As a novelty of the statistical analysis, we study the variability of the KamLand results with respect the use of diverse statistics. A new statistic, not used before is proposed. Moreover, in the analysis of the SNO spectrum a novel technique is used in order to include full correlated errors among bins. Combining all data, we obtain the following best-fit parameters: we determine individual neutrino mixing parameters and their errors $ \\Delta m^2= 8.2\\pm 0.08\\times 10^{-5} \\eV^2,\\quad \\tan^2\\theta= 0.50^{+0.12}_{-0.07}.$ The impact of these results is discussed. We also estimate the individual elements of the neutrino mass matrix. In the framework of three neutrino oscillations we obtain the mass matrix: \\begin{eqnarray}M&=& eV \\pmatrix{1....

  15. Advances in powder diffraction analysis

    Energy Technology Data Exchange (ETDEWEB)

    Louer, D. [Lab. de Chimie du Solide et Inorganique Moleculaire, Rennes (France). Groupe de Cristallochimie

    1998-11-01

    Powder diffraction offers a wide spectrum of applications to solid-state scientists. The method traditionally used for phase analysis and the study of structural imperfections has benefited, in the last twenty years, from great advances in the instrumentation and computer-based approaches for pattern indexing and modelling. The factors at the origin of the metamorphosis of the method are presented. The major modern applications reported include quantitative analysis and the extraction of three-dimensional structural and microstructural properties. The use of pattern-fitting techniques for the characterization of the microstructure is discussed through applications to nanocrystalline materials. Remarkable results achieved in the solution of crystal structures are presented, as well as the impact in solid-state chemistry of powder crystallography, particularly for elucidating the crystal chemistry of families of compounds for which only powders are available. New strategies for solving the phase problem have been introduced and new classes of solids are being studied, such as drugs, coordination and organic compounds. (orig.) 100 refs.

  16. Advanced analysis and design for fire safety of steel structures

    CERN Document Server

    Li, Guoqiang

    2013-01-01

    Advanced Analysis and Design for Fire Safety of Steel Structures systematically presents the latest findings on behaviours of steel structural components in a fire, such as the catenary actions of restrained steel beams, the design methods for restrained steel columns, and the membrane actions of concrete floor slabs with steel decks. Using a systematic description of structural fire safety engineering principles, the authors illustrate the important difference between behaviours of an isolated structural element and the restrained component in a complete structure under fire conditions. The book will be an essential resource for structural engineers who wish to improve their understanding of steel buildings exposed to fires. It is also an ideal textbook for introductory courses in fire safety for master’s degree programs in structural engineering, and is excellent reading material for final-year undergraduate students in civil engineering and fire safety engineering. Furthermore, it successfully bridges th...

  17. Characteristics and popular topics of latest researches into the effects of air particulate matter on cardiovascular system by bibliometric analysis.

    Science.gov (United States)

    Jia, Xiaofeng; Guo, Xinbiao; Li, Haicun; An, Xinying; Zhao, Yingguang

    2013-03-01

    In recent years, many epidemiological and toxicological studies have investigated the adverse effects of air particulate matter (PM) on the cardiovascular system. However, it is difficult for the researchers to have a timely and effective overall command of the latest characteristics and popular topics in such a wide field. Different from the previous reviews, in which the research characteristics and trends are empirically concluded by experts, we try to have a comprehensive evaluation of the above topics for the first time by bibliometric analysis, a quantitative tool in information exploration. This study aims to introduce the bibliometric method into the field of PM and cardiovascular system. The articles were selected by searching PubMed/MEDLINE (from 2007 to 2012) using Medical Subject Headings (MeSH) terms "particulate matter" and "cardiovascular system". A total of 935 eligible articles and 1895 MeSH terms were retrieved and processed by the software Thomson Data Analyzer (TDA). The bibliographic information and the MeSH terms of these articles were classified and analyzed to summarize the research characteristics. The top 200 high-frequency MeSH terms (the cumulative frequency percentage was 74.2%) were clustered for popular-topic conclusion. We summarized the characteristics of published articles, of researcher collaborations and of the contents. Ten clusters of MeSH terms are presented. Six popular topics are concluded and elaborated for reference. Our study presents an overview of the characteristics and popular topics in the field of PM and cardiovascular system in the past five years by bibliometric tools, which may provide a new perspective for future researchers.

  18. ADVANCED POWER SYSTEMS ANALYSIS TOOLS

    Energy Technology Data Exchange (ETDEWEB)

    Robert R. Jensen; Steven A. Benson; Jason D. Laumb

    2001-08-31

    The use of Energy and Environmental Research Center (EERC) modeling tools and improved analytical methods has provided key information in optimizing advanced power system design and operating conditions for efficiency, producing minimal air pollutant emissions and utilizing a wide range of fossil fuel properties. This project was divided into four tasks: the demonstration of the ash transformation model, upgrading spreadsheet tools, enhancements to analytical capabilities using the scanning electron microscopy (SEM), and improvements to the slag viscosity model. The ash transformation model, Atran, was used to predict the size and composition of ash particles, which has a major impact on the fate of the combustion system. To optimize Atran key factors such as mineral fragmentation and coalescence, the heterogeneous and homogeneous interaction of the organically associated elements must be considered as they are applied to the operating conditions. The resulting model's ash composition compares favorably to measured results. Enhancements to existing EERC spreadsheet application included upgrading interactive spreadsheets to calculate the thermodynamic properties for fuels, reactants, products, and steam with Newton Raphson algorithms to perform calculations on mass, energy, and elemental balances, isentropic expansion of steam, and gasifier equilibrium conditions. Derivative calculations can be performed to estimate fuel heating values, adiabatic flame temperatures, emission factors, comparative fuel costs, and per-unit carbon taxes from fuel analyses. Using state-of-the-art computer-controlled scanning electron microscopes and associated microanalysis systems, a method to determine viscosity using the incorporation of grey-scale binning acquired by the SEM image was developed. The image analysis capabilities of a backscattered electron image can be subdivided into various grey-scale ranges that can be analyzed separately. Since the grey scale's intensity

  19. Mid-water Software Tools and the Application to Processing and Analysis of the Latest Generation Multibeam Sonars

    Science.gov (United States)

    Gee, L.; Doucet, M.

    2010-12-01

    The latest generation of multibeam sonars now has the ability to map the water-column, along with the seafloor. Currently, the users of these sonars have a limited view of the mid-water data in real-time, and if they do store the data, they are restricted to replaying it only, with no ability for further analysis. The water-column data has the potential to address a number of research areas including detection of small targets (wrecks, etc.) above the seabed, mapping of fish and marine mammals and a wide range of physical oceanographic processes. However, researchers have been required to develop their own in-house software tools before they can even begin their study of the water column data. This paper describes the development of more general software tools for the full processing of raw sonar data (bathymetry, backscatter and water-column) to yield output products suitable for visualization in a 4D time-synchronized environment. The huge water-column data volumes generated by the new sonars, combined with the variety of data formats from the different sonar manufacturers, provides a significant challenge in the design and development of tools that can be applied to the wide variety of applications. The development of the mid-water tools on this project addressed this problem by using a unified way of storing the water column data in a generic water column format (GWC). The sonar data are converted into the GWC by re-integrating the water column packets with time-based navigation and attitude, such that downstream in the workflow, the tools will have access to all relevant data of any particular ping. Dependent on the application and the resolution requirements, the conversion process also allows simple sub-sampling. Additionally, each file is indexed to enable fast non-linear lookup and extraction of any packet type or packet type collection in the sonar file. These tools also fully exploit multi-core and hyper-threading technologies to maximize the throughput

  20. Latest Research: Genetic Links

    Science.gov (United States)

    ... Current Issue Past Issues Feature: Vision Latest Research: Genetic Links Past Issues / Summer 2008 Table of Contents ... inside the eye is a risk factor for glaucoma. Summer 2008 Issue: Volume 3 Number 3 Page ...

  1. Double Chooz: Latest results

    CERN Document Server

    Crespo-Anadón, J I

    2014-01-01

    The latest results from the Double Chooz experiment on the neutrino mixing angle $\\theta_{13}$ are presented. A detector located at an average distance of 1050 m from the two reactor cores of the Chooz nuclear power plant has accumulated a live time of 467.90 days, corresponding to an exposure of 66.5 GW-ton-year (reactor power $\\times$ detector mass $\\times$ live time). A revised analysis has boosted the signal efficiency and reduced the backgrounds and systematic uncertainties compared to previous publications, paving the way for the two detector phase. The measured $\\sin^2 2\\theta_{13} = 0.090^{+0.032}_{-0.029}$ is extracted from a fit to the energy spectrum. A deviation from the prediction above a visible energy of 4 MeV is found, being consistent with an unaccounted reactor flux effect, which does not affect the $\\theta_{13}$ result. A consistent value of $\\theta_{13}$ is measured in a rate-only fit to the number of observed candidates as a function of the reactor power, confirming the robustness of the ...

  2. The Latest Advance in the Research of Black Tea in China%我国红茶最新研究进展

    Institute of Scientific and Technical Information of China (English)

    王辉; 龚淑英; 李淦成; 张俊; 解静

    2012-01-01

    Quality formation of black tea is closely related to tea varieties,the ecological environment in tea garden and tea processing technology.The latest research progress of domestic black tea is elaborated and the black tea development is also prospected,which could provide theoretical basis for production of black tea.%红茶品质的形成与茶树品种原料、茶园生态环境和茶叶加工工艺等紧密相关。本文阐述了国内红茶最新研究进展,并对红茶发展前景进行了展望,为红茶生产提供理论依据。

  3. Advances in social media analysis

    CERN Document Server

    Cocea, Mihaela; Wiratunga, Nirmalie; Goker, Ayse

    2015-01-01

    This volume presents a collection of carefully selected contributions in the area of social media analysis. Each chapter opens up a number of research directions that have the potential to be taken on further in this rapidly growing area of research. The chapters are diverse enough to serve a number of directions of research with Sentiment Analysis as the dominant topic in the book. The authors have provided a broad range of research achievements from multimodal sentiment identification to emotion detection in a Chinese microblogging website. The book will be useful to research students, academics and practitioners in the area of social media analysis.  .

  4. Failure and damage analysis of advanced materials

    CERN Document Server

    Sadowski, Tomasz

    2015-01-01

    The papers in this volume present basic concepts and new developments in failure and damage analysis with focus on advanced materials such as composites, laminates, sandwiches and foams, and also new metallic materials. Starting from some mathematical foundations (limit surfaces, symmetry considerations, invariants) new experimental results and their analysis are shown. Finally, new concepts for failure prediction and analysis will be introduced and discussed as well as new methods of failure and damage prediction for advanced metallic and non-metallic materials. Based on experimental results the traditional methods will be revised.

  5. Advanced analysis methods in particle physics

    Energy Technology Data Exchange (ETDEWEB)

    Bhat, Pushpalatha C.; /Fermilab

    2010-10-01

    Each generation of high energy physics experiments is grander in scale than the previous - more powerful, more complex and more demanding in terms of data handling and analysis. The spectacular performance of the Tevatron and the beginning of operations of the Large Hadron Collider, have placed us at the threshold of a new era in particle physics. The discovery of the Higgs boson or another agent of electroweak symmetry breaking and evidence of new physics may be just around the corner. The greatest challenge in these pursuits is to extract the extremely rare signals, if any, from huge backgrounds arising from known physics processes. The use of advanced analysis techniques is crucial in achieving this goal. In this review, I discuss the concepts of optimal analysis, some important advanced analysis methods and a few examples. The judicious use of these advanced methods should enable new discoveries and produce results with better precision, robustness and clarity.

  6. Advanced Analysis Methods in Particle Physics

    Energy Technology Data Exchange (ETDEWEB)

    Bhat, Pushpalatha C. [Fermilab

    1900-01-01

    Each generation of high energy physics experiments is grander in scale than the previous – more powerful, more complex and more demanding in terms of data handling and analysis. The spectacular performance of the Tevatron and the beginning of operations of the Large Hadron Collider, have placed us at the threshold of a new era in particle physics. The discovery of the Higgs boson or another agent of electroweak symmetry breaking and evidence of new physics may be just around the corner. The greatest challenge in these pursuits is to extract the extremely rare signals, if any, from huge backgrounds arising from known physics processes. The use of advanced analysis techniques is crucial in achieving this goal. In this review, I discuss the concepts of optimal analysis, some important advanced analysis methods and a few examples. The judicious use of these advanced methods should enable new discoveries and produce results with better precision, robustness and clarity.

  7. Advanced calculus a transition to analysis

    CERN Document Server

    Dence, Thomas P

    2010-01-01

    Designed for a one-semester advanced calculus course, Advanced Calculus explores the theory of calculus and highlights the connections between calculus and real analysis -- providing a mathematically sophisticated introduction to functional analytical concepts. The text is interesting to read and includes many illustrative worked-out examples and instructive exercises, and precise historical notes to aid in further exploration of calculus. Ancillary list: * Companion website, Ebook- http://www.elsevierdirect.com/product.jsp?isbn=9780123749550 * Student Solutions Manual- To come * Instructor

  8. Advanced Color Image Processing and Analysis

    CERN Document Server

    2013-01-01

    This volume does much more than survey modern advanced color processing. Starting with a historical perspective on ways we have classified color, it sets out the latest numerical techniques for analyzing and processing colors, the leading edge in our search to accurately record and print what we see. The human eye perceives only a fraction of available light wavelengths, yet we live in a multicolor world of myriad shining hues. Colors rich in metaphorical associations make us “purple with rage” or “green with envy” and cause us to “see red.” Defining colors has been the work of centuries, culminating in today’s complex mathematical coding that nonetheless remains a work in progress: only recently have we possessed the computing capacity to process the algebraic matrices that reproduce color more accurately. With chapters on dihedral color and image spectrometers, this book provides technicians and researchers with the knowledge they need to grasp the intricacies of today’s color imaging.

  9. 蛋白激酶B与乳腺癌的最新研究进展%The latest research advances in protein kinase B and breast cancer

    Institute of Scientific and Technical Information of China (English)

    张超; 孙治君

    2012-01-01

    丝氨酸/苏氨酸蛋白激酶即蛋白激酶B(protein kinase B,PKB/Akt)是细胞内最重要的激酶之一,它能够通过接受整合多种细胞外信号产生多种生物学效应,包括对细胞增殖、迁徙、生长、周期、能量代谢、死亡等多方面的影响.Akt在乳腺癌发展过程中的作用成为研究热点.现就近两年来Akt与乳腺癌的重要研究成果予以综述.%The protein serine/threonine kinase Akt, also known as protein kinase B ( PKB ), is one of the most important kinases in cell. Akt integrates a plethora of extracellular signals to generate diverse outcomes, including proliferation, motility, growth, cell cycle, glucose homeostasis, and cell death. What is the role of Akt in the breast cancer has become a research focus. In this review, we will show the most important and latest research about Akt with breast cancer.

  10. Lecture notes for Advanced Time Series Analysis

    DEFF Research Database (Denmark)

    Madsen, Henrik; Holst, Jan

    1997-01-01

    A first version of this notes was used at the lectures in Grenoble, and they are now extended and improved (together with Jan Holst), and used in Ph.D. courses on Advanced Time Series Analysis at IMM and at the Department of Mathematical Statistics, University of Lund, 1994, 1997, ......A first version of this notes was used at the lectures in Grenoble, and they are now extended and improved (together with Jan Holst), and used in Ph.D. courses on Advanced Time Series Analysis at IMM and at the Department of Mathematical Statistics, University of Lund, 1994, 1997, ...

  11. Advanced microtechnologies for cytogenetic analysis

    DEFF Research Database (Denmark)

    Kwasny, Dorota; Vedarethinam, Indumathi; Shah, Pranjul Jaykumar;

    2012-01-01

    Cytogenetic and molecular cytogenetic analyses, which aim to detect chromosome abnormalities, are routinely performed in cytogenetic laboratories all over the world. Traditional cytogenetic studies are performed by analyzing the banding pattern of chromosomes, and are complemented by molecular...... cytogenetic techniques such as fluorescent in situ hybridization (FISH). To improve FISH application in cytogenetic analysis the issues with long experimental time, high volumes of expensive reagents and requirement for trained technicians need to be addressed. The protocol has recently evolved towards...... to introduce automation in the cytogenetic laboratories at a microscale. We have developed membrane based micro perfusion systems capable of expansion of lymphocytes in a shorter time and at a smaller scale. The simulated and experimental results show very efficient exchange of the growth medium...

  12. Advances in carbonate exploration and reservoir analysis

    Science.gov (United States)

    Garland, J.; Neilson, J.E.; Laubach, S.E.; Whidden, K.J.

    2012-01-01

    Carbonate reservoirs contain an increasingly important percentage of the world’s hydrocarbon reserves. This volume presents key recent advances in carbonate exploration and reservoir analysis. As well as a comprehensive overview of the trends in carbonate over the years, the volume focuses on four key areas:

  13. NATO Advanced Study Institute on Advances in Microlocal Analysis

    CERN Document Server

    1986-01-01

    The 1985 Castel vecchio-Pas coli NATO Advanced Study Institute is aimed to complete the trilogy with the two former institutes I organized : "Boundary Value Problem for Evolution Partial Differential Operators", Liege, 1976 and "Singularities in Boundary Value Problems", Maratea, 1980. It was indeed necessary to record the considerable progress realized in the field of the propagation of singularities of Schwartz Distri­ butions which led recently to the birth of a new branch of Mathema­ tical Analysis called Microlocal Analysis. Most of this theory was mainly built to be applied to distribution solutions of linear partial differential problems. A large part of this institute still went in this direction. But, on the other hand, it was also time to explore the new trend to use microlocal analysis In non linear differential problems. I hope that the Castelvecchio NATO ASI reached its purposes with the help of the more famous authorities in the field. The meeting was held in Tuscany (Italy) at Castelvecchio-P...

  14. Advancing Family Business Research Through Narrative Analysis

    DEFF Research Database (Denmark)

    Dawson, Alexandra; Hjorth, Daniel

    2012-01-01

    Despite advances in family business research, the field would benefit from greater methodological rigor. However, rigor does not mean convergence of methodologies. In this article, the authors adopt a novel approach, based on narrative analysis, to address the succession process in a family...... business. This interpretive perspective is appropriate for family business studies, which address multifaceted and complex social constructs that are performed by different actors in multiple contexts. The analysis highlights five key themes centering on leadership style and succession, trust...

  15. Transfer RNA's latest port of call

    DEFF Research Database (Denmark)

    Santos, Manuel A S; Orellana, Omar; Ibba, Michael

    2010-01-01

    of the International tRNA Workshop just a few months after the awarding of the Nobel Prize for the structure of the ribosome was particularly fitting. Over 250 scientists gathered from January 28 to February 2, 2010 in the charming town of Aveiro on the Atlantic coast of Portugal to discuss the latest advances in our...

  16. Advanced Interval Management: A Benefit Analysis

    Science.gov (United States)

    Timer, Sebastian; Peters, Mark

    2016-01-01

    This document is the final report for the NASA Langley Research Center (LaRC)- sponsored task order 'Possible Benefits for Advanced Interval Management Operations.' Under this research project, Architecture Technology Corporation performed an analysis to determine the maximum potential benefit to be gained if specific Advanced Interval Management (AIM) operations were implemented in the National Airspace System (NAS). The motivation for this research is to guide NASA decision-making on which Interval Management (IM) applications offer the most potential benefit and warrant further research.

  17. Optoelectronic Devices Advanced Simulation and Analysis

    CERN Document Server

    Piprek, Joachim

    2005-01-01

    Optoelectronic devices transform electrical signals into optical signals and vice versa by utilizing the sophisticated interaction of electrons and light within micro- and nano-scale semiconductor structures. Advanced software tools for design and analysis of such devices have been developed in recent years. However, the large variety of materials, devices, physical mechanisms, and modeling approaches often makes it difficult to select appropriate theoretical models or software packages. This book presents a review of devices and advanced simulation approaches written by leading researchers and software developers. It is intended for scientists and device engineers in optoelectronics, who are interested in using advanced software tools. Each chapter includes the theoretical background as well as practical simulation results that help to better understand internal device physics. The software packages used in the book are available to the public, on a commercial or noncommercial basis, so that the interested r...

  18. Advanced Excel for scientific data analysis

    CERN Document Server

    De Levie, Robert

    2004-01-01

    Excel is by far the most widely distributed data analysis software but few users are aware of its full powers. Advanced Excel For Scientific Data Analysis takes off from where most books dealing with scientific applications of Excel end. It focuses on three areas-least squares, Fourier transformation, and digital simulation-and illustrates these with extensive examples, often taken from the literature. It also includes and describes a number of sample macros and functions to facilitate common data analysis tasks. These macros and functions are provided in uncompiled, computer-readable, easily

  19. Recent Advances in Morphological Cell Image Analysis

    Directory of Open Access Journals (Sweden)

    Shengyong Chen

    2012-01-01

    Full Text Available This paper summarizes the recent advances in image processing methods for morphological cell analysis. The topic of morphological analysis has received much attention with the increasing demands in both bioinformatics and biomedical applications. Among many factors that affect the diagnosis of a disease, morphological cell analysis and statistics have made great contributions to results and effects for a doctor. Morphological cell analysis finds the cellar shape, cellar regularity, classification, statistics, diagnosis, and so forth. In the last 20 years, about 1000 publications have reported the use of morphological cell analysis in biomedical research. Relevant solutions encompass a rather wide application area, such as cell clumps segmentation, morphological characteristics extraction, 3D reconstruction, abnormal cells identification, and statistical analysis. These reports are summarized in this paper to enable easy referral to suitable methods for practical solutions. Representative contributions and future research trends are also addressed.

  20. Latest advances in excreted/secreted antigens of Toxoplasma gondii%弓形虫排泄分泌抗原研究的新进展

    Institute of Scientific and Technical Information of China (English)

    叶强; 张德林

    2012-01-01

    简要介绍了弓形虫排泄分泌抗原的制备及其组分,对近几年国内外排泄分泌抗原在免疫功能及应用方面的研究进展加以综述,并对其在疫苗研制上的成果和前景进行了探讨,旨在为弓形虫病疫苗的研制提供参考。%This paper briefly describes the preparation and components of excreted/secreted antigens (ESAs) of Toxoplasma gondii, reviews the recent advances in immune functions and application of the ES- As,and discusses the achievements and prospects in the development of vaccines against T. gondii infec- tion,to provide some valuable references for the vaccine development of T. gondii.

  1. Statistical assessment and hydrological utility of the latest multi-satellite precipitation analysis IMERG in Ganjiang River basin

    Science.gov (United States)

    Li, Na; Tang, Guoqiang; Zhao, Ping; Hong, Yang; Gou, Yabin; Yang, Kai

    2017-01-01

    This study aims to statistically and hydrologically assess the hydrological utility of the latest Integrated Multi-satellitE Retrievals from Global Precipitation Measurement (IMERG) multi-satellite constellation over the mid-latitude Ganjiang River basin in China. The investigations are conducted at hourly and 0.1° resolutions throughout the rainy season from March 12 to September 30, 2014. Two high-quality quantitative precipitation estimation (QPE) datasets, i.e., a gauge-corrected radar mosaic QPE product (RQPE) and a highly dense network of 1200 rain gauges, are used as the reference. For the implementation of the study, first, we compare IMERG product and RQPE with rain gauge-interpolated data, respectively. The results indicate that both remote sensing products can estimate precipitation fairly well over the basin, while RQPE significantly outperforms IMERG product in almost all the studied cases. The correlation coefficients of RQPE (CC = 0.98 and CC = 0.67) are much higher than those of IMERG product (CC = 0.80 and CC = 0.33) at basin and grid scales, respectively. Then, the hydrological assessment is conducted with the Coupled Routing and Excess Storage (CREST) model under multiple parameterization scenarios, in which the model is calibrated using the rain gauge-interpolated data, RQPE, and IMERG products respectively. During the calibration period (from March 12 to May 31), the simulated streamflow based on rain gauge-interpolated data shows the highest Nash-Sutcliffe coefficient efficiency (NSCE) value (0.92), closely followed by the RQPE (NSCE = 0.84), while IMERG product performs barely acceptable (NSCE = 0.56). During the validation period (from June 1 to September 30), the three rainfall datasets are used to force the CREST model based on all the three calibrated parameter sets (i.e., nine combinations in total). RQPE outperforms rain gauge-interpolated data and IMERG product in all validation scenarios, possibly due to its advantageous capability

  2. System Level Analysis of LTE-Advanced

    DEFF Research Database (Denmark)

    Wang, Yuanye

    This PhD thesis focuses on system level analysis of Multi-Component Carrier (CC) management for Long Term Evolution (LTE)-Advanced. Cases where multiple CCs are aggregated to form a larger bandwidth are studied. The analysis is performed for both local area and wide area networks. In local area......, Time Division Duplexing (TDD) is chosen as the duplexing mode in this study. The performance with different network time synchronization levels is compared, and it is observed that achieving time synchronization significantly improves the uplink performance without penalizing much of the downlink.......e., some users can access all CCs (LTE-Advanced users), whereas some are restricted to operate within a single CC (release 8 users). First, load balancing across the multiple CCs is analyzed. Several known approaches are studied and the best one is identified. A cross-CC packet scheduler is afterwards...

  3. Probabilistic Durability Analysis in Advanced Engineering Design

    Directory of Open Access Journals (Sweden)

    A. Kudzys

    2000-01-01

    Full Text Available Expedience of probabilistic durability concepts and approaches in advanced engineering design of building materials, structural members and systems is considered. Target margin values of structural safety and serviceability indices are analyzed and their draft values are presented. Analytical methods of the cumulative coefficient of correlation and the limit transient action effect for calculation of reliability indices are given. Analysis can be used for probabilistic durability assessment of carrying and enclosure metal, reinforced concrete, wood, plastic, masonry both homogeneous and sandwich or composite structures and some kinds of equipments. Analysis models can be applied in other engineering fields.

  4. Advances in statistical models for data analysis

    CERN Document Server

    Minerva, Tommaso; Vichi, Maurizio

    2015-01-01

    This edited volume focuses on recent research results in classification, multivariate statistics and machine learning and highlights advances in statistical models for data analysis. The volume provides both methodological developments and contributions to a wide range of application areas such as economics, marketing, education, social sciences and environment. The papers in this volume were first presented at the 9th biannual meeting of the Classification and Data Analysis Group (CLADAG) of the Italian Statistical Society, held in September 2013 at the University of Modena and Reggio Emilia, Italy.

  5. Advanced Power Plant Development and Analysis Methodologies

    Energy Technology Data Exchange (ETDEWEB)

    A.D. Rao; G.S. Samuelsen; F.L. Robson; B. Washom; S.G. Berenyi

    2006-06-30

    Under the sponsorship of the U.S. Department of Energy/National Energy Technology Laboratory, a multi-disciplinary team led by the Advanced Power and Energy Program of the University of California at Irvine is defining the system engineering issues associated with the integration of key components and subsystems into advanced power plant systems with goals of achieving high efficiency and minimized environmental impact while using fossil fuels. These power plant concepts include 'Zero Emission' power plants and the 'FutureGen' H2 co-production facilities. The study is broken down into three phases. Phase 1 of this study consisted of utilizing advanced technologies that are expected to be available in the 'Vision 21' time frame such as mega scale fuel cell based hybrids. Phase 2 includes current state-of-the-art technologies and those expected to be deployed in the nearer term such as advanced gas turbines and high temperature membranes for separating gas species and advanced gasifier concepts. Phase 3 includes identification of gas turbine based cycles and engine configurations suitable to coal-based gasification applications and the conceptualization of the balance of plant technology, heat integration, and the bottoming cycle for analysis in a future study. Also included in Phase 3 is the task of acquiring/providing turbo-machinery in order to gather turbo-charger performance data that may be used to verify simulation models as well as establishing system design constraints. The results of these various investigations will serve as a guide for the U. S. Department of Energy in identifying the research areas and technologies that warrant further support.

  6. ATRF Houses the Latest DNA Sequencing Technologies | Poster

    Science.gov (United States)

    By Ashley DeVine, Staff Writer By the end of October, the Advanced Technology Research Facility (ATRF) will be one of the few facilities in the world to house all of the latest DNA sequencing technologies.

  7. Latest advances in innate antiviral defence

    OpenAIRE

    Irving, Aaron; Williams, Bryan RG

    2009-01-01

    Recent identification of key components in the pattern recognition receptor pathway of retinoic acid-inducible gene-1-like receptors, coupled with the characterisation of a new cytoplasmic DNA-sensing molecule, has led to a greater understanding of the role that viral nucleic acids play in activating innate immunity. This activation of type-I interferon is essential for both limiting viral infection and stimulating activation of the adaptive immune response.

  8. Advanced SWOT Analysis of E-Commerce

    Directory of Open Access Journals (Sweden)

    Muhammad Awais

    2012-03-01

    Full Text Available This research paper describes the invention and accessibility of internet connectivity and powerful online tools has resulted a new commerce era that is e-commerce, which has completely revolutionized the conventional concept of business. E-commerce deals with selling and purchasing of goods and services through internet and computer networks. E-commerce can enhance economic growth, increase business opportunities, competitiveness, better and profitable access to markets. E-Commerce is emerging as a new way of helping business enterprises to compete in the market and thus contributing to economic success. In this research paper we will discuss about advanced SWOT analysis of E-commerce which will comprise of strengths, weaknesses, opportunities and threats faced by e-commerce in current scenario.

  9. Latest advances in antiplatelet and anticoagulation therapy for peripheral arterial occlusive disease (PAOD)%外周动脉闭塞性疾病的抗血小板与抗凝治疗进展

    Institute of Scientific and Technical Information of China (English)

    王学斌; 陈跃鑫

    2015-01-01

    Objective:To investigate the latest advances in antiplatelet and anticoagulation therapy for the treatment of PAOD. Methods: The data of antiplatelet and anticoagulation drugs in the treatment of PAOD domestically and internationally in recent years was collected and analyzed.Results and conclusion: Antiplatelet therapy helps to reduce the incidence rate of cardiovascular events in patients with PAOD. By increasing the patency rate of revascularization, furthermore it can also improve the prognosis of patients. Anticoagulant drugs still play an important role in the treatment of patients with PAOD, particularly in some special cases. The combined application of anticoagulant drugs and antiplatelet drugs will provide a new idea for pharmacotherapy of patients with PAOD.%目的:探讨外周动脉闭塞性疾病抗血小板与抗凝治疗及进展.方法:查询近几年国内外关于外周动脉闭塞性疾病抗血小板和抗凝药物治疗文献并进行分析.结果和结论:抗血小板治疗有助于降低外周动脉闭塞性疾病患者心脑血管事件发生率,并通过提高血管重建术后的通畅率,改善患者的预后.抗凝药物在外周动脉闭塞性疾病患者的治疗中仍应占有一席之地,尤其是在某些特定情况下.抗凝和抗血小板药物合理的联用可能为外周动脉闭塞性疾病患者的药物治疗提供新的思路.

  10. Advances in variational and hemivariational inequalities theory, numerical analysis, and applications

    CERN Document Server

    Migórski, Stanisław; Sofonea, Mircea

    2015-01-01

    Highlighting recent advances in variational and hemivariational inequalities with an emphasis on theory, numerical analysis and applications, this volume serves as an indispensable resource to graduate students and researchers interested in the latest results from recognized scholars in this relatively young and rapidly-growing field. Particularly, readers will find that the volume’s results and analysis present valuable insights into the fields of pure and applied mathematics, as well as civil, aeronautical, and mechanical engineering. Researchers and students will find new results on well posedness to stationary and evolutionary inequalities and their rigorous proofs. In addition to results on modeling and abstract problems, the book contains new results on the numerical methods for variational and hemivariational inequalities. Finally, the applications presented illustrate the use of these results in the study of miscellaneous mathematical models which describe the contact between deformable bodies and a...

  11. Recent advances and trends in the liquid-chromatography-mass spectrometry analysis of flavonoids.

    Science.gov (United States)

    de Villiers, André; Venter, Pieter; Pasch, Harald

    2016-01-22

    Flavonoids have elicited significant attention as a result of their importance in plants, their influence on the properties of natural-product derived commodities and especially as a consequence of their purported health benefits. Research in all of these fields relies heavily on accurate analytical data, and in this LC-MS has come to play an influential role by allowing relatively fast tentative identification and accurate quantification of low levels of flavonoids in a variety of matrices. The field has undergone rapid expansion in the last decade due to important developments in both HPLC and MS instrumentation, which nowadays allow much faster and more accurate analysis of flavonoids. This contribution aims to provide an overview of these developments and their application in flavonoid analysis since 2009. The discussion is focussed first on methodologies which provide improved LC separation of flavonoids in terms of speed and/or resolution, including ultra high pressure LC (UHPLC), monolithic and superficially porous phases, high temperature LC (HTLC) and comprehensive two-dimensional LC (LC×LC). The fundamental background relevant to each of these will be briefly outlined, as well as the implications and promise of their hyphenation to MS. Secondly, the possibilities and limitations of a range of the latest MS instruments available in combination with advanced LC analysis will be discussed, including ion trap, triple quadrupole, time-of-flight, Orbitrap, ion mobility and various hybrid instruments. Examples from the latest literature will be used to illustrate the performance gains achievable in flavonoid analysis by the hyphenation of advanced LC separation and high-end MS instrumentation.

  12. The Latest from CMS

    CERN Multimedia

    2009-01-01

    CMS is on track to be ready for physics one month in advance of the LHC restart. The final installations are being completed and tests are being run to ensure that the experiment is as well prepared as possible to exploit sustained LHC operation throughout 2010. Physics week in Bologna, Italy, was a valuable time for CMS collaborators to discuss preparations for numerous physics analyses, as well as the performance of the detector during the recent data-taking period with cosmics (CRAFT 09). During this five-week exercise, more than 300 million cosmic events were recorded with the magnetic field on. This large data-set is being used to further improve the sub-detector alignment, calibration and performance whilst awaiting p-p collisions. Meanwhile, in the experimental cavern, Wolfram Zeuner, Deputy Technical Coordinator of CMS, reports "We are now very nearly closed up again. We are just doing the final clean-up work and are ready t...

  13. Quit Smoking: Latest NIH Research

    Science.gov (United States)

    ... this page please turn Javascript on. Feature: Quit Smoking Latest NIH Research Past Issues / Winter 2011 Table ... with chest X-rays. Clinical Trials Related to Smoking Clinical trials are scientific studies that try to ...

  14. Advanced Materials and Solids Analysis Research Core (AMSARC)

    Science.gov (United States)

    The Advanced Materials and Solids Analysis Research Core (AMSARC), centered at the U.S. Environmental Protection Agency's (EPA) Andrew W. Breidenbach Environmental Research Center in Cincinnati, Ohio, is the foundation for the Agency's solids and surfaces analysis capabilities. ...

  15. Evaluation of CDA energetics in the prototype LMFBR with latest knowledge and tools

    Energy Technology Data Exchange (ETDEWEB)

    Tobita, Yoshiharu; Morita, Koji; Kawada, Ken-ichi; Niwa, Hajime; Nonaka, Nobuyuki [Japan Nuclear Cycle Development Institute, Oarai Engineering Center, Oarai, Ibaraki (Japan)

    1999-07-01

    The sequences of an unprotected loss-of-flow accident in the prototype LMFBR has been evaluated, as a part of reactor safety research, reflecting the latest experimental and analytical knowledge on core disruptive accident (CDA). In the evaluation, the event progression scenarios and the major physical parameters were selected, based on the latest experimental knowledge and code validation studies on the transient fuel behavior and material motion during the last decade, such that associated phenomenological uncertainties were well covered within physically reasonable ranges. With the safety research knowledge and advanced accident analysis codes, which have been made available lately, the CDA energetics was assessed to be much more benign in comparison with the former analysis. In other words, we have demonstrated that our former CDA analysis is sufficiently conservative. (author)

  16. Latest Magnet News

    CERN Multimedia

    Miele, P.

    PRODUCTION OF TB COMPONENTS Production of the main components of the Barrel Toroid coils is well advanced in industry. They are being delivered to CERN and piled up in Building 180 ready for integration. Three coil casings have been completed at ALSTOM Power Switzerland and are standing in Building 180 waiting for integration (left photo). Ten double pancakes out of 16 have been completed at ANSALDO. Four of them have been delivered to CERN (right photo). Two vacuum vessels have been delivered to CERN by Felguera Construcciones Mecanicas, Spain. TB INTEGRATION Integrations of the TB components are performed at CERN in Building 180. Integration 1, which is the assembly of the two double pancakes into the coil casing (cold mass), has started. Preparation work is ongoing at the moment and the turning frame will be delivered to CERN mid-July 2002, ready for operation. Integration 2, which is the assembly of the cold mass and related components into the vacuum vessel, started with assembly of the cool...

  17. Latest Progress on the QUBIC Instrument

    CERN Document Server

    Ghribi, A; Battistelli, E S; Bau, A; Bergé, L; Bernard, J-Ph; Bersanelli, M; Bigot-Sazy, M-A; Bordier, G; Bunn, E T; Cavaliere, F; Chanial, P; Coppolecchia, A; Decourcelle, T; De Bernardis, P; De Petris, M; Drilien, A-A; Dumoulin, L; Falvella, M C; Gault, A; Gervasi, M; Giard, M; Gradziel, M; Grandsire, L; Gayer, D; Hamilton, J-Ch; Haynes, V; Hiraut, Y-G; Holtzer, N; Kaplan, J; Korotkov, A; Lande, J; Lowitz, A; Maffei, B; Marnieros, S; Martino, J; Masi, S; Mennella, A; Montier, L; Murphy, A; Ng, M W; Olivieri, E; Pajot, F; Passerini, A; Piacentini, F; Piat, M; Piccirillo, L; Pisano, G; Prêle, D; Rambaud, D; Rigaut, O; Rosset, C; Salatino, M; Schillaci, A; Scully, S; O'Sullivan, C; Tartari, A; Timbie, P; Tucker, G; Vibert, L; Voisin, F; Watson, B; Zannoni, M

    2013-01-01

    QUBIC is a unique instrument that crosses the barriers between classical imaging architectures and interferometry taking advantage from both for high sensitivity and systematics mitigation. The scientific target is the detection of the primordial gravitational waves imprint on the Cosmic Microwave Background which are the proof of inflation, holy grail of modern cosmology. In this paper, we show the latest advances in the development of the architecture and the sub-systems of the first module of this instrument to be deployed in Dome Charlie Concordia base - Antarctica in 2015.

  18. Latest Progress on the QUBIC Instrument

    Science.gov (United States)

    Ghribi, A.; Aumont, J.; Battistelli, E. S.; Bau, A.; Bélier, B.; Bergé, L.; Bernard, J.-Ph.; Bersanelli, M.; Bigot-Sazy, M.-A.; Bordier, G.; Bunn, E. T.; Cavaliere, F.; Chanial, P.; Coppolecchia, A.; Decourcelle, T.; De Bernardis, P.; De Petris, M.; Drilien, A.-A.; Dumoulin, L.; Falvella, M. C.; Gault, A.; Gervasi, M.; Giard, M.; Gradziel, M.; Grandsire, L.; Gayer, D.; Hamilton, J.-Ch.; Haynes, V.; Giraud-Héraud, Y.; Holtzer, N.; Kaplan, J.; Korotkov, A.; Lande, J.; Lowitz, A.; Maffei, B.; Marnieros, S.; Martino, J.; Masi, S.; Mennella, A.; Montier, L.; Murphy, A.; Ng, M. W.; Olivieri, E.; Pajot, F.; Passerini, A.; Piacentini, F.; Piat, M.; Piccirillo, L.; Pisano, G.; Prêle, D.; Rambaud, D.; Rigaut, O.; Rosset, C.; Salatino, M.; Schillaci, A.; Scully, S.; O'Sullivan, C.; Tartari, A.; Timbie, P.; Tucker, G.; Vibert, L.; Voisin, F.; Watson, B.; Zannoni, M.

    2014-09-01

    QUBIC is a unique instrument that crosses the barriers between classical imaging architectures and interferometry taking advantage from both high sensitivity and systematics mitigation. The scientific target is to detect primordial gravitational waves created by inflation by the polarization they imprint on the cosmic microwave background—the holy grail of modern cosmology. In this paper, we show the latest advances in the development of the architecture and the sub-systems of the first module of this instrument to be deployed at Dome Charlie Concordia base—Antarctica in 2015.

  19. The Latest from ATLAS

    CERN Multimedia

    2009-01-01

    Since November 2008, ATLAS has undertaken detailed maintenance, consolidation and repair work on the detector (see Bulletin of 20 July 2009). Today, the fraction of the detector that is operational has increased compared to last year: less than 1% of dead channels for most of the sub-systems. "We are going to start taking data this year with a detector which is even more efficient than it was last year," agrees ATLAS Spokesperson, Fabiola Gianotti. By mid-September the detector was fully closed again, and the cavern sealed. The magnet system has been operated at nominal current for extensive periods over recent months. Once the cavern was sealed, ATLAS began two weeks of combined running. Right now, subsystems are joining the run incrementally until the point where the whole detector is integrated and running as one. In the words of ATLAS Technical Coordinator, Marzio Nessi: "Now we really start physics." In parallel, the analysis ...

  20. Advanced Modeling, Simulation and Analysis (AMSA) Capability Roadmap Progress Review

    Science.gov (United States)

    Antonsson, Erik; Gombosi, Tamas

    2005-01-01

    Contents include the following: NASA capability roadmap activity. Advanced modeling, simulation, and analysis overview. Scientific modeling and simulation. Operations modeling. Multi-special sensing (UV-gamma). System integration. M and S Environments and Infrastructure.

  1. Advanced Fingerprint Analysis Project Fingerprint Constituents

    Energy Technology Data Exchange (ETDEWEB)

    GM Mong; CE Petersen; TRW Clauss

    1999-10-29

    The work described in this report was focused on generating fundamental data on fingerprint components which will be used to develop advanced forensic techniques to enhance fluorescent detection, and visualization of latent fingerprints. Chemical components of sweat gland secretions are well documented in the medical literature and many chemical techniques are available to develop latent prints, but there have been no systematic forensic studies of fingerprint sweat components or of the chemical and physical changes these substances undergo over time.

  2. Progressive Failure Analysis of Advanced Composites

    Science.gov (United States)

    2008-07-25

    NASA – Langley Research Center 1 Joan Andreu Mayugo University of Girona 1 2 Contents 1 Introduction 11 2 UVARM subroutine 13 2.1 Overview...32] Turon A, Camanho PP, Costa J, Dávila CG. A damage model for the simulation of delamination in advanced composites under variable- mode loading...conference, New York, 1960. p. 63–78. [34] Turon A, Dávila CG, Camanho PP, Costa J. An engineering solution for using coarse meshes in the

  3. Latest Electroweak Results from CDF

    Energy Technology Data Exchange (ETDEWEB)

    Lancaster, Mark

    2010-05-01

    The latest results in electroweak physics from proton anti-proton collisions at the Fermilab Tevatron recorded by the CDF detector are presented. The results provide constraints on parton distribution functions, the mass of the Higgs boson and beyond the Standard Model physics.

  4. 新生儿重症监护室五年死亡病例分析%Analysis of neonatal death in NICU during the latest 5 years

    Institute of Scientific and Technical Information of China (English)

    康文清; 刘大鹏; 陈宇辉; 孙慧清; 熊虹

    2009-01-01

    目的 了解新生儿重症监护室5年新生儿死亡原因及变迁,探讨预防措施,降低病死率.方法 对新生儿重症监护室2004年1月至2008年12月5年间死亡的69例病例进行回顾性分析.结果 (1)男女比例1.7:1,早产儿占34.8%,胎龄≤32周的早产儿占早产儿死亡病例的70.8%;(2)以早期新生儿死亡为主,占59.4%,住院3 d内死亡占69.6%;(3)早产儿前三位死亡原因为呼吸窘迫综合征、败血症、硬肿症,占早产儿死亡数的70.8%;足月儿前三位死亡原因为败血症、重度窒息、肺炎,占足月儿死亡数的77.1%;(4)呼吸窘迫综合征病死率逐年下降,败血症、重度窒息病死率无下降趋势.结论 要降低我省新生儿的病死率,必须加强围生期保健,减少早产儿的出生,深入推广新生儿新法复苏,积极控制感染.%Objective To analyze the cause and change of neonatal death during the latest 5 years,to discuss the ways to decrease the mortality.Methods A retrospective analysis of 69 cases in NICU were performed from Jan 2004 to Dec 2008.Results(1)The sex ratio of male to female was 1.7:1.The preterm infants accounted for 34.8%,preterm infants with gestational ages of less than 32 weeks accounted for 70.8% of the total premature deaths.(2)59.4% of the deaths in newborn infants occurred in the first 7days of life.69.6% occurred within 3 days after admission.(3)The three leading causes of premature infant death were RDS,sepsis and scleredema neonatorum,accounted for 75% of premature death.The three leading canses of full term death were sepsis,neonate severe asphyxia and pneumonia,accounted for 71.1% of all full term death.(4)The newborn who died of RDS were gradually decreasing.Those who died of sepsis and severe asphyxia weren't changing.Condusion Heath care during the perinatal period should be strengthened to decrease the premature birth and asphyxia.The neonatal new resuscitation technique should be widely adovocated and neonatal sepsis should

  5. Advanced Software Methods for Physics Analysis

    Science.gov (United States)

    Lista, L.

    2006-01-01

    Unprecedented data analysis complexity is experienced in modern High Energy Physics experiments. The complexity arises from the growing size of recorded data samples, the large number of data analyses performed by different users in each single experiment, and the level of complexity of each single analysis. For this reason, the requirements on software for data analysis impose a very high level of reliability. We present two concrete examples: the former from BaBar experience with the migration to a new Analysis Model with the definition of a new model for the Event Data Store, the latter about a toolkit for multivariate statistical and parametric Monte Carlo analysis developed using generic programming.

  6. Advancing Alternative Analysis: Integration of Decision Science

    DEFF Research Database (Denmark)

    Malloy, Timothy F; Zaunbrecher, Virginia M; Batteate, Christina;

    2016-01-01

    Decision analysis-a systematic approach to solving complex problems-offers tools and frameworks to support decision making that are increasingly being applied to environmental challenges. Alternatives analysis is a method used in regulation and product design to identify, compare, and evaluate th...

  7. Advanced transport systems analysis, modeling, and evaluation of performances

    CERN Document Server

    Janić, Milan

    2014-01-01

    This book provides a systematic analysis, modeling and evaluation of the performance of advanced transport systems. It offers an innovative approach by presenting a multidimensional examination of the performance of advanced transport systems and transport modes, useful for both theoretical and practical purposes. Advanced transport systems for the twenty-first century are characterized by the superiority of one or several of their infrastructural, technical/technological, operational, economic, environmental, social, and policy performances as compared to their conventional counterparts. The advanced transport systems considered include: Bus Rapid Transit (BRT) and Personal Rapid Transit (PRT) systems in urban area(s), electric and fuel cell passenger cars, high speed tilting trains, High Speed Rail (HSR), Trans Rapid Maglev (TRM), Evacuated Tube Transport system (ETT), advanced commercial subsonic and Supersonic Transport Aircraft (STA), conventionally- and Liquid Hydrogen (LH2)-fuelled commercial air trans...

  8. Computational intelligence for big data analysis frontier advances and applications

    CERN Document Server

    Dehuri, Satchidananda; Sanyal, Sugata

    2015-01-01

    The work presented in this book is a combination of theoretical advancements of big data analysis, cloud computing, and their potential applications in scientific computing. The theoretical advancements are supported with illustrative examples and its applications in handling real life problems. The applications are mostly undertaken from real life situations. The book discusses major issues pertaining to big data analysis using computational intelligence techniques and some issues of cloud computing. An elaborate bibliography is provided at the end of each chapter. The material in this book includes concepts, figures, graphs, and tables to guide researchers in the area of big data analysis and cloud computing.

  9. Advanced symbolic analysis for VLSI systems methods and applications

    CERN Document Server

    Shi, Guoyong; Tlelo Cuautle, Esteban

    2014-01-01

    This book provides comprehensive coverage of the recent advances in symbolic analysis techniques for design automation of nanometer VLSI systems. The presentation is organized in parts of fundamentals, basic implementation methods and applications for VLSI design. Topics emphasized include  statistical timing and crosstalk analysis, statistical and parallel analysis, performance bound analysis and behavioral modeling for analog integrated circuits . Among the recent advances, the Binary Decision Diagram (BDD) based approaches are studied in depth. The BDD-based hierarchical symbolic analysis approaches, have essentially broken the analog circuit size barrier. In particular, this book   • Provides an overview of classical symbolic analysis methods and a comprehensive presentation on the modern  BDD-based symbolic analysis techniques; • Describes detailed implementation strategies for BDD-based algorithms, including the principles of zero-suppression, variable ordering and canonical reduction; • Int...

  10. Advances in microfluidics for environmental analysis.

    Science.gov (United States)

    Jokerst, Jana C; Emory, Jason M; Henry, Charles S

    2012-01-07

    During the past few years, a growing number of groups have recognized the utility of microfluidic devices for environmental analysis. Microfluidic devices offer a number of advantages and in many respects are ideally suited to environmental analyses. Challenges faced in environmental monitoring, including the ability to handle complex and highly variable sample matrices, lead to continued growth and research. Additionally, the need to operate for days to months in the field requires further development of robust, integrated microfluidic systems. This review examines recently published literature on the applications of microfluidic systems for environmental analysis and provides insight in the future direction of the field.

  11. Modeling and analysis of advanced binary cycles

    Energy Technology Data Exchange (ETDEWEB)

    Gawlik, K.

    1997-12-31

    A computer model (Cycle Analysis Simulation Tool, CAST) and a methodology have been developed to perform value analysis for small, low- to moderate-temperature binary geothermal power plants. The value analysis method allows for incremental changes in the levelized electricity cost (LEC) to be determined between a baseline plant and a modified plant. Thermodynamic cycle analyses and component sizing are carried out in the model followed by economic analysis which provides LEC results. The emphasis of the present work is on evaluating the effect of mixed working fluids instead of pure fluids on the LEC of a geothermal binary plant that uses a simple Organic Rankine Cycle. Four resources were studied spanning the range of 265{degrees}F to 375{degrees}F. A variety of isobutane and propane based mixtures, in addition to pure fluids, were used as working fluids. This study shows that the use of propane mixtures at a 265{degrees}F resource can reduce the LEC by 24% when compared to a base case value that utilizes commercial isobutane as its working fluid. The cost savings drop to 6% for a 375{degrees}F resource, where an isobutane mixture is favored. Supercritical cycles were found to have the lowest cost at all resources.

  12. Cina Benteng: The Latest Generations and Acculturation

    Directory of Open Access Journals (Sweden)

    Billy Nathan Setiawan

    2015-03-01

    Full Text Available The aim of this paper was to investigate the acculturation process encountered by the two latest generations of Cina Benteng. A Skype interview was conducted with two young Cina Benteng descents. The analysis was also supported by insightful remark from the parents of the two interviewees. This study discovers that the two generations seem to respond to the acculturation process in different ways. However, although some traditions are no longer relevant to the later generation, their identity as a Chinese descent cannot be easily removed.

  13. Latest oscillation results from T2K

    CERN Document Server

    Khabibullin, Marat

    2011-01-01

    The latest oscillation results obtained in the off-axis accelerator neutrino experiment T2K are presented. In the data sample, corresponding to 1.43 x 10^20 protons on target, 6 electron neutrino candidate events pass the selection criteria, while the expected number of background events for sin^2 2\\theta_{13}=0 is 1.5 \\pm 0.3 (syst.). The probability to observe six or more candidate events due to background is 0.7%, equivalent to 2.5-sigma significance. In the muon neutrino disappearance analysis the obtained atmospheric oscillation parameters are consistent with results from the Super-Kamiokande and MINOS experiments.

  14. Advanced CMOS Radiation Effects Testing and Analysis

    Science.gov (United States)

    Pellish, J. A.; Marshall, P. W.; Rodbell, K. P.; Gordon, M. S.; LaBel, K. A.; Schwank, J. R.; Dodds, N. A.; Castaneda, C. M.; Berg, M. D.; Kim, H. S.; Phan, A. M.; Seidleck, C. M.

    2014-01-01

    Presentation at the annual NASA Electronic Parts and Packaging (NEPP) Program Electronic Technology Workshop (ETW). The material includes an update of progress in this NEPP task area over the past year, which includes testing, evaluation, and analysis of radiation effects data on the IBM 32 nm silicon-on-insulator (SOI) complementary metal oxide semiconductor (CMOS) process. The testing was conducted using test vehicles supplied by directly by IBM.

  15. Decision Analysis of Advanced Scout Helicopter Candidates

    Science.gov (United States)

    1980-01-01

    assist the ASH SSG by constructing a comprehensive ASH evaluation model utilizing multi-attribute utility assessment ( MAUA ) modeling. ~~UA is a forre...results are included as well. The output of the MAUA model is a numerical representation of the worth of each ASH candidate. These numbers are...instance of a methodology called Multi-Attribute Utility Analysis ( MAUA ). In general, MAUA is characterized by the represen- tation of outcomes in terms

  16. Advanced analysis for structural steel building design

    Institute of Scientific and Technical Information of China (English)

    Wai Fah CHEN

    2008-01-01

    The 2005 AISC LRFD Specifications for Structural Steel Buildings are making it possible for designers to recognize explicitly the structural resistance provided within the elastic and inelastic ranges of beha-vior and up to the maximum load limit state. There is an increasing awareness of the need for practical second-order analysis approaches for a direct determination of overall structural system response. This paper attempts to present a simple, concise and reasonably comprehens-ive introduction to some of the theoretical and practical approaches which have been used in the traditional and modern processes of design of steel building structures.

  17. Advanced calculus an introduction to classical analysis

    CERN Document Server

    Brand, Louis

    2006-01-01

    A course in analysis that focuses on the functions of a real variable, this text is geared toward upper-level undergraduate students. It introduces the basic concepts in their simplest setting and illustrates its teachings with numerous examples, practical theorems, and coherent proofs.Starting with the structure of the system of real and complex numbers, the text deals at length with the convergence of sequences and series and explores the functions of a real variable and of several variables. Subsequent chapters offer a brief and self-contained introduction to vectors that covers important a

  18. Linking advanced fracture models to structural analysis

    Energy Technology Data Exchange (ETDEWEB)

    Chiesa, Matteo

    2001-07-01

    Shell structures with defects occur in many situations. The defects are usually introduced during the welding process necessary for joining different parts of the structure. Higher utilization of structural materials leads to a need for accurate numerical tools for reliable prediction of structural response. The direct discretization of the cracked shell structure with solid finite elements in order to perform an integrity assessment of the structure in question leads to large size problems, and makes such analysis infeasible in structural application. In this study a link between local material models and structural analysis is outlined. An ''ad hoc'' element formulation is used in order to connect complex material models to the finite element framework used for structural analysis. An improved elasto-plastic line spring finite element formulation, used in order to take cracks into account, is linked to shell elements which are further linked to beam elements. In this way one obtain a global model of the shell structure that also accounts for local flexibilities and fractures due to defects. An important advantage with such an approach is a direct fracture mechanics assessment e.g. via computed J-integral or CTOD. A recent development in this approach is the notion of two-parameter fracture assessment. This means that the crack tip stress tri-axiality (constraint) is employed in determining the corresponding fracture toughness, giving a much more realistic capacity of cracked structures. The present thesis is organized in six research articles and an introductory chapter that reviews important background literature related to this work. Paper I and II address the performance of shell and line spring finite elements as a cost effective tool for performing the numerical calculation needed to perform a fracture assessment. In Paper II a failure assessment, based on the testing of a constraint-corrected fracture mechanics specimen under tension, is

  19. Multispectral laser imaging for advanced food analysis

    Science.gov (United States)

    Senni, L.; Burrascano, P.; Ricci, M.

    2016-07-01

    A hardware-software apparatus for food inspection capable of realizing multispectral NIR laser imaging at four different wavelengths is herein discussed. The system was designed to operate in a through-transmission configuration to detect the presence of unwanted foreign bodies inside samples, whether packed or unpacked. A modified Lock-In technique was employed to counterbalance the significant signal intensity attenuation due to transmission across the sample and to extract the multispectral information more efficiently. The NIR laser wavelengths used to acquire the multispectral images can be varied to deal with different materials and to focus on specific aspects. In the present work the wavelengths were selected after a preliminary analysis to enhance the image contrast between foreign bodies and food in the sample, thus identifying the location and nature of the defects. Experimental results obtained from several specimens, with and without packaging, are presented and the multispectral image processing as well as the achievable spatial resolution of the system are discussed.

  20. Advances in the environmental analysis of polychlorinated naphthalenes and toxaphene.

    Science.gov (United States)

    Kucklick, John R; Helm, Paul A

    2006-10-01

    Recent advances in the analysis of the chlorinated environmental pollutants polychlorinated naphthalenes (PCNs) and toxaphene are highlighted in this review. Method improvements have been realized for PCNs over the past decade in isomer-specific quantification, peak resolution, and the availability of mass-labeled standards. Toxaphene method advancements include the application of new capillary gas chromatographic (GC) stationary phases, mass spectrometry (MS), especially ion trap MS, and the availability of Standard Reference Materials that are value-assigned for total toxaphene and selected congener concentrations. An area of promise for the separation of complex mixtures such as PCNs and toxaphene is the development of multidimensional GC techniques. The need for continued advancements and efficiencies in the analysis of contaminants such as PCNs and toxaphene remains as monitoring requirements for these compound classes are established under international agreements.

  1. Advanced computational tools for 3-D seismic analysis

    Energy Technology Data Exchange (ETDEWEB)

    Barhen, J.; Glover, C.W.; Protopopescu, V.A. [Oak Ridge National Lab., TN (United States)] [and others

    1996-06-01

    The global objective of this effort is to develop advanced computational tools for 3-D seismic analysis, and test the products using a model dataset developed under the joint aegis of the United States` Society of Exploration Geophysicists (SEG) and the European Association of Exploration Geophysicists (EAEG). The goal is to enhance the value to the oil industry of the SEG/EAEG modeling project, carried out with US Department of Energy (DOE) funding in FY` 93-95. The primary objective of the ORNL Center for Engineering Systems Advanced Research (CESAR) is to spearhead the computational innovations techniques that would enable a revolutionary advance in 3-D seismic analysis. The CESAR effort is carried out in collaboration with world-class domain experts from leading universities, and in close coordination with other national laboratories and oil industry partners.

  2. Polybrominated Diphenyl Ethers in Dryer Lint: An Advanced Analysis Laboratory

    Science.gov (United States)

    Thompson, Robert Q.

    2008-01-01

    An advanced analytical chemistry laboratory experiment is described that involves environmental analysis and gas chromatography-mass spectrometry. Students analyze lint from clothes dryers for traces of flame retardant chemicals, polybrominated diphenylethers (PBDEs), compounds receiving much attention recently. In a typical experiment, ng/g…

  3. Recent Advances in Multidisciplinary Analysis and Optimization, part 3

    Science.gov (United States)

    Barthelemy, Jean-Francois M. (Editor)

    1989-01-01

    This three-part document contains a collection of technical papers presented at the Second NASA/Air Force Symposium on Recent Advances in Multidisciplinary Analysis and Optimization, held September 28-30, 1988 in Hampton, Virginia. The topics covered include: aircraft design, aeroelastic tailoring, control of aeroelastic structures, dynamics and control of flexible structures, structural design, design of large engineering systems, application of artificial intelligence, shape optimization, software development and implementation, and sensitivity analysis.

  4. Digital spectral analysis parametric, non-parametric and advanced methods

    CERN Document Server

    Castanié, Francis

    2013-01-01

    Digital Spectral Analysis provides a single source that offers complete coverage of the spectral analysis domain. This self-contained work includes details on advanced topics that are usually presented in scattered sources throughout the literature.The theoretical principles necessary for the understanding of spectral analysis are discussed in the first four chapters: fundamentals, digital signal processing, estimation in spectral analysis, and time-series models.An entire chapter is devoted to the non-parametric methods most widely used in industry.High resolution methods a

  5. Advances in independent component analysis and learning machines

    CERN Document Server

    Bingham, Ella; Laaksonen, Jorma; Lampinen, Jouko

    2015-01-01

    In honour of Professor Erkki Oja, one of the pioneers of Independent Component Analysis (ICA), this book reviews key advances in the theory and application of ICA, as well as its influence on signal processing, pattern recognition, machine learning, and data mining. Examples of topics which have developed from the advances of ICA, which are covered in the book are: A unifying probabilistic model for PCA and ICA Optimization methods for matrix decompositions Insights into the FastICA algorithmUnsupervised deep learning Machine vision and image retrieval A review of developments in the t

  6. Latest ATLAS results on $\\phi_s$

    CERN Document Server

    Reznicek, Pavel; The ATLAS collaboration

    2017-01-01

    New Physics effects beyond the predictions of the Standard Model may manifest in the $CP$-violation of $b$-hadron decays. This paper presents the latest analysis of $B^0_s \\to J/\\psi\\phi$ decay at the ATLAS experiment, measuring the $CP$-violating phase $\\phi_s$, the decay width $\\Gamma_s$ and the difference of widths between the mass eigenstates $\\Delta\\Gamma_s$. The latest results are using integrated luminosity of 14.3 fb$^{-1}$ collected by the ATLAS detector from $\\sqrt{s}$ = 8 TeV $pp$ collisions at the Large Hadron Collider, and are statistically combined with the results from 4.9 fb$^{-1}$ of $\\sqrt{s}$ = 7 TeV data, leading to: \\begin{eqnarray*} \\phi_s & = & -0.090 \\pm 0.078 \\;\\mathrm{(stat.)} \\pm 0.041 \\;\\mathrm{(syst.)~rad} ,\\;\\;\\\\ \\Delta\\Gamma_s & = & 0.085 \\pm 0.011 \\;\\mathrm{(stat.)} \\pm 0.007 \\;\\mathrm{(syst.)~ps}^{-1} ,\\;\\;\\\\ \\Gamma_s & = & 0.675 \\pm 0.003 \\;\\mathrm{(stat.)} \\pm 0.003 \\;\\mathrm{(syst.)~ps}^{-1}. \\end{eqnarray*} The results are also presented in the form...

  7. Advanced Post-Irradiation Examination Capabilities Alternatives Analysis Report

    Energy Technology Data Exchange (ETDEWEB)

    Jeff Bryan; Bill Landman; Porter Hill

    2012-12-01

    An alternatives analysis was performed for the Advanced Post-Irradiation Capabilities (APIEC) project in accordance with the U.S. Department of Energy (DOE) Order DOE O 413.3B, “Program and Project Management for the Acquisition of Capital Assets”. The Alternatives Analysis considered six major alternatives: ? No Action ? Modify Existing DOE Facilities – capabilities distributed among multiple locations ? Modify Existing DOE Facilities – capabilities consolidated at a few locations ? Construct New Facility ? Commercial Partnership ? International Partnerships Based on the alternatives analysis documented herein, it is recommended to DOE that the advanced post-irradiation examination capabilities be provided by a new facility constructed at the Materials and Fuels Complex at the Idaho National Laboratory.

  8. Advanced Thermodynamic Analysis and Evaluation of a Supercritical Power Plant

    Directory of Open Access Journals (Sweden)

    George Tsatsaronis

    2012-06-01

    Full Text Available A conventional exergy analysis can highlight the main components having high thermodynamic inefficiencies, but cannot consider the interactions among components or the true potential for the improvement of each component. By splitting the exergy destruction into endogenous/exogenous and avoidable/unavoidable parts, the advanced exergy analysis is capable of providing additional information to conventional exergy analysis for improving the design and operation of energy conversion systems. This paper presents the application of both a conventional and an advanced exergy analysis to a supercritical coal-fired power plant. The results show that the ratio of exogenous exergy destruction differs quite a lot from component to component. In general, almost 90% of the total exergy destruction within turbines comes from their endogenous parts, while that of feedwater preheaters contributes more or less 70% to their total exergy destruction. Moreover, the boiler subsystem is proven to have a large amount of exergy destruction caused by the irreversibilities within the remaining components of the overall system. It is also found that the boiler subsystem still has the largest avoidable exergy destruction; however, the enhancement efforts should focus not only on its inherent irreversibilities but also on the inefficiencies within the remaining components. A large part of the avoidable exergy destruction within feedwater preheaters is exogenous; while that of the remaining components is mostly endogenous indicating that the improvements mainly depend on advances in design and operation of the component itself.

  9. Development of the advanced PHWR technology -Design and analysis of CANDU advanced fuel-

    Energy Technology Data Exchange (ETDEWEB)

    Suk, Hoh Chun; Shim, Kee Sub; Byun, Taek Sang; Park, Kwang Suk; Kang, Heui Yung; Kim, Bong Kee; Jung, Chang Joon; Lee, Yung Wook; Bae, Chang Joon; Kwon, Oh Sun; Oh, Duk Joo; Im, Hong Sik; Ohn, Myung Ryong; Lee, Kang Moon; Park, Joo Hwan; Lee, Eui Joon [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1995-07-01

    This is the `94 annual report of the CANDU advanced fuel design and analysis project, and describes CANFLEX fuel design and mechanical integrity analysis, reactor physics analysis and safety analysis of the CANDU-6 with the CANFLEX-NU. The following is the R and D scope of this fiscal year : (1) Detail design of CANFLEX-NU and detail analysis on the fuel integrity, reactor physics and safety. (a) Detail design and mechanical integrity analysis of the bundle (b) CANDU-6 refueling simulation, and analysis on the Xe transients and adjuster system capability (c) Licensing strategy establishment and safety analysis for the CANFLEX-NU demonstration demonstration irradiation in a commercial CANDU-6. (2) Production and revision of CANFLEX-NU fuel design documents (a) Production and approval of CANFLEX-NU reference drawing, and revisions of fuel design manual and technical specifications (b) Production of draft physics design manual. (3) Basic research on CANFLEX-SEU fuel. 55 figs, 21 tabs, 45 refs. (Author).

  10. Advances in Mid-Infrared Spectroscopy for Chemical Analysis

    Science.gov (United States)

    Haas, Julian; Mizaikoff, Boris

    2016-06-01

    Infrared spectroscopy in the 3-20 μm spectral window has evolved from a routine laboratory technique into a state-of-the-art spectroscopy and sensing tool by benefitting from recent progress in increasingly sophisticated spectra acquisition techniques and advanced materials for generating, guiding, and detecting mid-infrared (MIR) radiation. Today, MIR spectroscopy provides molecular information with trace to ultratrace sensitivity, fast data acquisition rates, and high spectral resolution catering to demanding applications in bioanalytics, for example, and to improved routine analysis. In addition to advances in miniaturized device technology without sacrificing analytical performance, selected innovative applications for MIR spectroscopy ranging from process analysis to biotechnology and medical diagnostics are highlighted in this review.

  11. Advanced approaches to failure mode and effect analysis (FMEA applications

    Directory of Open Access Journals (Sweden)

    D. Vykydal

    2015-10-01

    Full Text Available The present paper explores advanced approaches to the FMEA method (Failure Mode and Effect Analysis which take into account the costs associated with occurrence of failures during the manufacture of a product. Different approaches are demonstrated using an example FMEA application to production of drawn wire. Their purpose is to determine risk levels, while taking account of the above-mentioned costs. Finally, the resulting priority levels are compared for developing actions mitigating the risks.

  12. Advances in oriental document analysis and recognition techniques

    CERN Document Server

    Lee, Seong-Whan

    1999-01-01

    In recent years, rapid progress has been made in computer processing of oriental languages, and the research developments in this area have resulted in tremendous changes in handwriting processing, printed oriental character recognition, document analysis and recognition, automatic input methodologies for oriental languages, etc. Advances in computer processing of oriental languages can also be seen in multimedia computing and the World Wide Web. Many of the results in those domains are presented in this book.

  13. Advances in Intelligence and Security Informatics

    CERN Document Server

    Mao, Wenji

    2012-01-01

    The Intelligent Systems Series comprises titles that present state of the art knowledge and the latest advances in intelligent systems. Its scope includes theoretical studies, design methods, and real-world implementations and applications. Traditionally, Intelligence and Security Informatics (ISI) research and applications have focused on information sharing and data mining, social network analysis, infrastructure protection and emergency responses for security informatics. With the continuous advance of IT technologies and the increasing sophistication of national and international securi

  14. [Advanced data analysis and visualization for clinical laboratory].

    Science.gov (United States)

    Inada, Masanori; Yoneyama, Akiko

    2011-01-01

    This paper describes visualization techniques that help identify hidden structures in clinical laboratory data. The visualization of data is helpful for a rapid and better understanding of the characteristics of data sets. Various charts help the user identify trends in data. Scatter plots help prevent misinterpretations due to invalid data by identifying outliers. The representation of experimental data in figures is always useful for communicating results to others. Currently, flexible methods such as smoothing methods and latent structure analysis are available owing to the presence of advanced hardware and software. Principle component analysis, which is a well-known technique used to reduce multidimensional data sets, can be carried out on a personal computer. These methods could lead to advanced visualization with regard to exploratory data analysis. In this paper, we present 3 examples in order to introduce advanced data analysis. In the first example, a smoothing spline was fitted to a time-series from the control chart which is not in a state of statistical control. The trend line was clearly extracted from the daily measurements of the control samples. In the second example, principal component analysis was used to identify a new diagnostic indicator for Graves' disease. The multi-dimensional data obtained from patients were reduced to lower dimensions, and the principle components thus obtained summarized the variation in the data set. In the final example, a latent structure analysis for a Gaussian mixture model was used to draw complex density functions suitable for actual laboratory data. As a result, 5 clusters were extracted. The mixed density function of these clusters represented the data distribution graphically. The methods used in the above examples make the creation of complicated models for clinical laboratories more simple and flexible.

  15. Brief notes in advanced DSP Fourier analysis with Matlab

    CERN Document Server

    Grigoryan, Artyom M

    2009-01-01

    Based on the authors' research in Fourier analysis, Brief Notes in Advanced DSP: Fourier Analysis with MATLAB® addresses many concepts and applications of digital signal processing (DSP). The included MATLAB® codes illustrate how to apply the ideas in practice.The book begins with the basic concept of the discrete Fourier transformation and its properties. It then describes lifting schemes, integer transformations, the discrete cosine transform, and the paired transform method for calculating the discrete Hadamard transform. The text also examines the decomposition of the 1D signal by so-calle

  16. Advanced Signal Analysis for Forensic Applications of Ground Penetrating Radar

    Energy Technology Data Exchange (ETDEWEB)

    Steven Koppenjan; Matthew Streeton; Hua Lee; Michael Lee; Sashi Ono

    2004-06-01

    Ground penetrating radar (GPR) systems have traditionally been used to image subsurface objects. The main focus of this paper is to evaluate an advanced signal analysis technique. Instead of compiling spatial data for the analysis, this technique conducts object recognition procedures based on spectral statistics. The identification feature of an object type is formed from the training vectors by a singular-value decomposition procedure. To illustrate its capability, this procedure is applied to experimental data and compared to the performance of the neural-network approach.

  17. The Latest Books on Globalization

    Directory of Open Access Journals (Sweden)

    Elia Zaru

    2016-12-01

    Full Text Available The latest books published on globalization raise interesting issues which reflect upon the very complexity of the process we are facing. In The Great Convergence: Information Technology and the New Globalization Richard Baldwin proposes a history of globalization divided into two stages. As Baldwin argues, the process of globalization has to be divided into “old” and “new” age. The “old” globalization took place between 1820 and 1990. It was characterized by the “great divergence”, that is by the centralization of world income in today’s wealthy nations. However, since 1990 the sharing of world income has plummeted to where it was in 1900. According to Baldwin, this reversal of fortune is a symptom of a shift in the globalization process. The “new” globalization, driven by information technology, has combined high tech with low wages, and lead simultaneously to the industrialization of developing nations and deindustrialization of developed ones. This is the “great convergence”: in the “new” globalization rich and developing nations are alike and they face equal global challenges.

  18. Latest design of gate valves

    Energy Technology Data Exchange (ETDEWEB)

    Kurzhofer, U.; Stolte, J.; Weyand, M.

    1996-12-01

    Babcock Sempell, one of the most important valve manufacturers in Europe, has delivered valves for the nuclear power industry since the beginning of the peaceful application of nuclear power in the 1960s. The latest innovation by Babcock Sempell is a gate valve that meets all recent technical requirements of the nuclear power technology. At the moment in the United States, Germany, Sweden, and many other countries, motor-operated gate and globe valves are judged very critically. Besides the absolute control of the so-called {open_quotes}trip failure,{close_quotes} the integrity of all valve parts submitted to operational forces must be maintained. In case of failure of the limit and torque switches, all valve designs have been tested with respect to the quality of guidance of the gate. The guidances (i.e., guides) shall avoid a tilting of the gate during the closing procedure. The gate valve newly designed by Babcock Sempell fulfills all these characteristic criteria. In addition, the valve has cobalt-free seat hardfacing, the suitability of which has been proven by friction tests as well as full-scale blowdown tests at the GAP of Siemens in Karlstein, West Germany. Babcock Sempell was to deliver more than 30 gate valves of this type for 5 Swedish nuclear power stations by autumn 1995. In the presentation, the author will report on the testing performed, qualifications, and sizing criteria which led to the new technical design.

  19. Zika Virus: the Latest Newcomer.

    Science.gov (United States)

    Saiz, Juan-Carlos; Vázquez-Calvo, Ángela; Blázquez, Ana B; Merino-Ramos, Teresa; Escribano-Romero, Estela; Martín-Acebes, Miguel A

    2016-01-01

    Since the beginning of this century, humanity has been facing a new emerging, or re-emerging, virus threat almost every year: West Nile, Influenza A, avian flu, dengue, Chikungunya, SARS, MERS, Ebola, and now Zika, the latest newcomer. Zika virus (ZIKV), a flavivirus transmitted by Aedes mosquitoes, was identified in 1947 in a sentinel monkey in Uganda, and later on in humans in Nigeria. The virus was mainly confined to the African continent until it was detected in south-east Asia the 1980's, then in the Micronesia in 2007 and, more recently in the Americas in 2014, where it has displayed an explosive spread, as advised by the World Health Organization, which resulted in the infection of hundreds of thousands of people. ZIKV infection was characterized by causing a mild disease presented with fever, headache, rash, arthralgia, and conjunctivitis, with exceptional reports of an association with Guillain-Barre syndrome (GBS) and microcephaly. However, since the end of 2015, an increase in the number of GBS associated cases and an astonishing number of microcephaly in fetus and new-borns in Brazil have been related to ZIKV infection, raising serious worldwide public health concerns. Clarifying such worrisome relationships is, thus, a current unavoidable goal. Here, we extensively review what is currently known about ZIKV, from molecular biology, transmission routes, ecology, and epidemiology, to clinical manifestations, pathogenesis, diagnosis, prophylaxis, and public health.

  20. Zika virus: the latest newcomer

    Directory of Open Access Journals (Sweden)

    Juan-Carlos eSaiz

    2016-04-01

    Full Text Available Since the beginning of this century, humanity has been facing a new emerging, or re-emerging, virus threat almost every year: West Nile, Influenza A, avian flu, dengue, Chikungunya, SARS, MERS, Ebola, and now Zika, the latest newcomer. Zika virus (ZIKV, a flavivirus transmitted by Aedes mosquitoes, was identified in 1947 in a sentinel monkey in Uganda, and later on in humans in Nigeria. The virus was mainly confined to the African continent until it was detected in south-east Asia the 1980´s, then in the Micronesia in 2007 and, more recently in the Americas in 2014, where it has displayed an explosive spread, as advised by the World Health Organization (WHO, which resulted in the infection of hundreds of thousands of people. ZIKV infection was characterized by causing a mild disease presented with fever, headache, rash, arthralgia, and conjunctivitis, with exceptional reports of an association with Guillain-Barre syndrome (GBS and microcephaly. However, since the end of 2015, an increase in the number of GBS associated cases and an astonishing number of microcephaly in foetus and new-borns in Brazil have been related to ZIKV infection, raising serious worldwide public health concerns. Clarifying such worrisome relationships is, thus, a current unavoidable goal. Here, we extensively review what is currently known about ZIKV, from molecular biology, transmission routes, ecology and epidemiology, to clinical manifestations, pathogenesis, diagnosis, prophylaxis and public health.

  1. Zika Virus: the Latest Newcomer

    Science.gov (United States)

    Saiz, Juan-Carlos; Vázquez-Calvo, Ángela; Blázquez, Ana B.; Merino-Ramos, Teresa; Escribano-Romero, Estela; Martín-Acebes, Miguel A.

    2016-01-01

    Since the beginning of this century, humanity has been facing a new emerging, or re-emerging, virus threat almost every year: West Nile, Influenza A, avian flu, dengue, Chikungunya, SARS, MERS, Ebola, and now Zika, the latest newcomer. Zika virus (ZIKV), a flavivirus transmitted by Aedes mosquitoes, was identified in 1947 in a sentinel monkey in Uganda, and later on in humans in Nigeria. The virus was mainly confined to the African continent until it was detected in south-east Asia the 1980’s, then in the Micronesia in 2007 and, more recently in the Americas in 2014, where it has displayed an explosive spread, as advised by the World Health Organization, which resulted in the infection of hundreds of thousands of people. ZIKV infection was characterized by causing a mild disease presented with fever, headache, rash, arthralgia, and conjunctivitis, with exceptional reports of an association with Guillain–Barre syndrome (GBS) and microcephaly. However, since the end of 2015, an increase in the number of GBS associated cases and an astonishing number of microcephaly in fetus and new-borns in Brazil have been related to ZIKV infection, raising serious worldwide public health concerns. Clarifying such worrisome relationships is, thus, a current unavoidable goal. Here, we extensively review what is currently known about ZIKV, from molecular biology, transmission routes, ecology, and epidemiology, to clinical manifestations, pathogenesis, diagnosis, prophylaxis, and public health. PMID:27148186

  2. Validation Database Based Thermal Analysis of an Advanced RPS Concept

    Science.gov (United States)

    Balint, Tibor S.; Emis, Nickolas D.

    2006-01-01

    Advanced RPS concepts can be conceived, designed and assessed using high-end computational analysis tools. These predictions may provide an initial insight into the potential performance of these models, but verification and validation are necessary and required steps to gain confidence in the numerical analysis results. This paper discusses the findings from a numerical validation exercise for a small advanced RPS concept, based on a thermal analysis methodology developed at JPL and on a validation database obtained from experiments performed at Oregon State University. Both the numerical and experimental configurations utilized a single GPHS module enabled design, resembling a Mod-RTG concept. The analysis focused on operating and environmental conditions during the storage phase only. This validation exercise helped to refine key thermal analysis and modeling parameters, such as heat transfer coefficients, and conductivity and radiation heat transfer values. Improved understanding of the Mod-RTG concept through validation of the thermal model allows for future improvements to this power system concept.

  3. Latest trends and directions of development of crowdfunding

    Directory of Open Access Journals (Sweden)

    Joanna Pieniążek

    2014-09-01

    Full Text Available The article discusses the latest trends and directions of development of crowdfunding on selected examples of English-language websites.The scope of work includes topics such as aggregates of crowdfunding sites, local investing, franchise, pre-sales platforms, open source sites and leveraging the competitive advantages of e-commerce platforms which offer product crowdfunding. This article aims to discuss the latest trends and directions of crowdfunding, assess their usefulness and the chances of popularising the ideas presented. The article provides an overview of the literature on the subject and an analysis of the selected sites, comparison sites and crowdfunding search engines.

  4. Advances in the Chemical Analysis and Biological Activities of Chuanxiong

    Directory of Open Access Journals (Sweden)

    Jin-Ao Duan

    2012-09-01

    Full Text Available Chuanxiong Rhizoma (Chuan-Xiong, CX, the dried rhizome of Ligusticum chuanxiong Hort. (Umbelliferae, is one of the most popular plant medicines in the World. Modern research indicates that organic acids, phthalides, alkaloids, polysaccharides, ceramides and cerebrosides are main components responsible for the bioactivities and properties of CX. Because of its complex constituents, multidisciplinary techniques are needed to validate the analytical methods that support CX’s use worldwide. In the past two decades, rapid development of technology has advanced many aspects of CX research. The aim of this review is to illustrate the recent advances in the chemical analysis and biological activities of CX, and to highlight new applications and challenges. Emphasis is placed on recent trends and emerging techniques.

  5. Latest analysis results and statistical interpretations for SUSY searches at √(s) = 13 TeV with two same-sign leptons, jets and E{sub T}{sup miss} at the ATLAS detector

    Energy Technology Data Exchange (ETDEWEB)

    Cardillo, Fabio; Tornambe, Peter [Albert-Ludwigs Universitaet Freiburg (Germany)

    2016-07-01

    A search for supersymmetric phenomena in final states with two leptons with the same electric charge, jets and missing transverse energy E{sub T}{sup miss} is presented. The production of same-sign lepton pairs or three leptons is only induced by rare Standard Model processes with very small cross-sections. The search thus benefits from little background and has a good exclusion potential in compressed SUSY spectra. This analysis has been performed already in Run-I of the LHC and provided powerful exclusion limits for various SUSY scenarios. In the ongoing Run-II, the search was conducted with the full dataset of pp collisions at √(s)=13 TeV recorded with the ATLAS detector in 2015 corresponding to a total integrated luminosity of 3.3 fb{sup -1}. The sensitivity to a big variety of supersymmetric models is illustrated by the interpretation of the results in the context of four different SUSY benchmark scenarios producing same-sign leptons signatures. The results can be used to set model-independent limits to new physics signals as well as increasing the existing limits on different supersymmetric scenarios with respect to the previous Run-I results. This talk presents the latest results of the same-sign/3L analysis published at the end of 2015. Furthermore, analysis details are addressed, and the prospects for the progressive data-taking during Run-II are shown.

  6. Advanced spot quality analysis in two-colour microarray experiments

    Directory of Open Access Journals (Sweden)

    Vetter Guillaume

    2008-09-01

    Full Text Available Abstract Background Image analysis of microarrays and, in particular, spot quantification and spot quality control, is one of the most important steps in statistical analysis of microarray data. Recent methods of spot quality control are still in early age of development, often leading to underestimation of true positive microarray features and, consequently, to loss of important biological information. Therefore, improving and standardizing the statistical approaches of spot quality control are essential to facilitate the overall analysis of microarray data and subsequent extraction of biological information. Findings We evaluated the performance of two image analysis packages MAIA and GenePix (GP using two complementary experimental approaches with a focus on the statistical analysis of spot quality factors. First, we developed control microarrays with a priori known fluorescence ratios to verify the accuracy and precision of the ratio estimation of signal intensities. Next, we developed advanced semi-automatic protocols of spot quality evaluation in MAIA and GP and compared their performance with available facilities of spot quantitative filtering in GP. We evaluated these algorithms for standardised spot quality analysis in a whole-genome microarray experiment assessing well-characterised transcriptional modifications induced by the transcription regulator SNAI1. Using a set of RT-PCR or qRT-PCR validated microarray data, we found that the semi-automatic protocol of spot quality control we developed with MAIA allowed recovering approximately 13% more spots and 38% more differentially expressed genes (at FDR = 5% than GP with default spot filtering conditions. Conclusion Careful control of spot quality characteristics with advanced spot quality evaluation can significantly increase the amount of confident and accurate data resulting in more meaningful biological conclusions.

  7. Fine analysis on advanced detection of transient electromagnetic method

    Institute of Scientific and Technical Information of China (English)

    Wang Bo; Liu Shengdong; Yang Zhen; Wang Zhijun; Huang Lanying

    2012-01-01

    Fault fracture zones and water-bearing bodies in front of the driving head are the main disasters in mine laneways,thus it is important to perform their advanced detection and prediction in advance in order to provide reliable technical support for the excavation.Based on the electromagnetic induction theory,we analyzed the characteristics of primary and secondary fields with a positive and negative wave form of current,proposed the fine processing of the advanced detection with variation rate of apparent resistivity and introduced in detail the computational formulae and procedures.The result of physical simulation experiments illustrate that the tectonic interface of modules can be judged by first-order rate of apparent resistivity with a boundary error of 5%,and the position of water body determined by the fine analysis method agrees well with the result of borehole drilling.This shows that in terms of distinguishing structure and aqueous anomalies,the first-order rate of apparent resistivity is more sensitive than the secondorder rate of apparent resistivity.However,some remaining problems are suggested for future solutions.

  8. Advanced Wireless Power Transfer Vehicle and Infrastructure Analysis (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Gonder, J.; Brooker, A.; Burton, E.; Wang, J.; Konan, A.

    2014-06-01

    This presentation discusses current research at NREL on advanced wireless power transfer vehicle and infrastructure analysis. The potential benefits of E-roadway include more electrified driving miles from battery electric vehicles, plug-in hybrid electric vehicles, or even properly equipped hybrid electric vehicles (i.e., more electrified miles could be obtained from a given battery size, or electrified driving miles could be maintained while using smaller and less expensive batteries, thereby increasing cost competitiveness and potential market penetration). The system optimization aspect is key given the potential impact of this technology on the vehicles, the power grid and the road infrastructure.

  9. Life-cycle cost analysis of advanced design mixer pump

    Energy Technology Data Exchange (ETDEWEB)

    Hall, M.N., Westinghouse Hanford

    1996-07-23

    This analysis provides cost justification for the Advanced Design Mixer Pump program based on the cost benefit to the Hanford Site of 4 mixer pump systems defined in terms of the life-cycle cost.A computer model is used to estimate the total number of service hours necessary for each mixer pump to operate over the 20-year retrieval sequence period for single-shell tank waste. This study also considered the double-shell tank waste retrieved prior to the single-shell tank waste which is considered the initial retrieval.

  10. Latest key technology for NGN

    Science.gov (United States)

    Ota, Toshihiko

    2007-11-01

    The several optical components and modules technologies are reviewed for use in Re-configurable Optical Add/Drop Multiplexter (ROADM) systems in Next Generation Network (NGN) ring networks. Especially, Athermal-AWG, PLC-ROADM and MEMS-WSS are now deployed in the actual field because of its maturity, good performance and highly reliability. In this paper, we introduced the technologies and actual performance and reliability data for actual use. In the near future, ROADM application must be more advanced and complex with these technologies and new technologies.

  11. Tool for Sizing Analysis of the Advanced Life Support System

    Science.gov (United States)

    Yeh, Hue-Hsie Jannivine; Brown, Cheryl B.; Jeng, Frank J.

    2005-01-01

    Advanced Life Support Sizing Analysis Tool (ALSSAT) is a computer model for sizing and analyzing designs of environmental-control and life support systems (ECLSS) for spacecraft and surface habitats involved in the exploration of Mars and Moon. It performs conceptual designs of advanced life support (ALS) subsystems that utilize physicochemical and biological processes to recycle air and water, and process wastes in order to reduce the need of resource resupply. By assuming steady-state operations, ALSSAT is a means of investigating combinations of such subsystems technologies and thereby assisting in determining the most cost-effective technology combination available. In fact, ALSSAT can perform sizing analysis of the ALS subsystems that are operated dynamically or steady in nature. Using the Microsoft Excel spreadsheet software with Visual Basic programming language, ALSSAT has been developed to perform multiple-case trade studies based on the calculated ECLSS mass, volume, power, and Equivalent System Mass, as well as parametric studies by varying the input parameters. ALSSAT s modular format is specifically designed for the ease of future maintenance and upgrades.

  12. Imaging spectroscopic analysis at the Advanced Light Source

    Energy Technology Data Exchange (ETDEWEB)

    MacDowell, A. A.; Warwick, T.; Anders, S.; Lamble, G.M.; Martin, M.C.; McKinney, W.R.; Padmore, H.A.

    1999-05-12

    One of the major advances at the high brightness third generation synchrotrons is the dramatic improvement of imaging capability. There is a large multi-disciplinary effort underway at the ALS to develop imaging X-ray, UV and Infra-red spectroscopic analysis on a spatial scale from. a few microns to 10nm. These developments make use of light that varies in energy from 6meV to 15KeV. Imaging and spectroscopy are finding applications in surface science, bulk materials analysis, semiconductor structures, particulate contaminants, magnetic thin films, biology and environmental science. This article is an overview and status report from the developers of some of these techniques at the ALS. The following table lists all the currently available microscopes at the. ALS. This article will describe some of the microscopes and some of the early applications.

  13. Advanced aerostatic analysis of long-span suspension bridges

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    As the span length of suspension bridges increases, the diameter of cables and thus the wind load acting on them, the nonlinear wind-structure interaction and the wind speed spatial non-uniformity all increase consequently, which may have unnegligible influence on the aerostatic behavior of long-span suspension bridges. In this work, a method of advanced aerostatic analysis is presented firstly by considering the geometric nonlinearity, the nonlinear wind-structures and wind speed spatial non-uniformity. By taking the Runyang Bridge over the Yangtze River as example, effects of the nonlinear wind-structure interaction, wind speed spatial non-uniformity, and the cable's wind load on the aerostatic behavior of the bridge are investigated analytically. The results showed that these factors all have important influence on the aerostatic behavior, and should be considered in the aerostatic analysis of long and particularly super long-span suspension bridges.

  14. 制浆造纸节水与高效水处理技术%The latest technology progress of water saving and advanced wastewater treatment in paper industry

    Institute of Scientific and Technical Information of China (English)

    房桂干; 施英乔; 符芳蓉

    2014-01-01

    The state standards for water quota of the paper industry (GB/T 18916.5-2012), clearly regulating that the water intake amount by per ton products should be reduced by 15.8% on average for 13 kinds of paper, had been taking into effects this year. In this study the whole pulping system would be divided into three separate water unit to evaluate the limitation value for each one in term of the main eflfuent character of total solids (TS). Each water unit was then conducted to optimize the water usage amount by water node technology. By using this technology, the total fresh water consumption per air dried ton paper products was reduced from the initial level of 41.1 m3 to that of 31.1 m3, decreased by 26.15%. In this paper was also introduced a new type of Petax ifne ifltration system to treat the white water, which could remove the ifne particles in diameter of more than 20 microns in white water. The treated white water was able to be reused as the high pressure spray water in wire part and press part of paper machines, meanwhile preventing from the problem of nozzle blockage. The application example of integrating the membrane technology with papermaking wastewater recycling project demonstrated that application of advanced treating technologies can reduce the discharge amount of waste water and COD level, with good economic beneifts and environmental beneifts achieved.%2013年开始实施的国家《造纸产品取水定额》GB/T 18916.5-2012,明确规定13种浆纸产品平均取水量必须降低15.8%。本研究组将某BCTMP化机浆厂工艺过程分为3个独立用水单元,将TS作为主要污染指标,估算出3个操作单元的极限数据,采用水节点技术对3个用水系统进行了优化设计,从而使清水用量由初始的41.1m3/A D t减少到31.1m3/A D t,节约新鲜水用量达26.1%。同时介绍了一种新型的Petax精细过滤系统,可以过滤去除白水中20μm以上的细小纤维,处理后白水用在网压部

  15. Advanced probabilistic risk analysis using RAVEN and RELAP-7

    Energy Technology Data Exchange (ETDEWEB)

    Rabiti, Cristian [Idaho National Lab. (INL), Idaho Falls, ID (United States); Alfonsi, Andrea [Idaho National Lab. (INL), Idaho Falls, ID (United States); Mandelli, Diego [Idaho National Lab. (INL), Idaho Falls, ID (United States); Cogliati, Joshua [Idaho National Lab. (INL), Idaho Falls, ID (United States); Kinoshita, Robert [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2014-06-01

    RAVEN, under the support of the Nuclear Energy Advanced Modeling and Simulation (NEAMS) program [1], is advancing its capability to perform statistical analyses of stochastic dynamic systems. This is aligned with its mission to provide the tools needed by the Risk Informed Safety Margin Characterization (RISMC) path-lead [2] under the Department Of Energy (DOE) Light Water Reactor Sustainability program [3]. In particular this task is focused on the synergetic development with the RELAP-7 [4] code to advance the state of the art on the safety analysis of nuclear power plants (NPP). The investigation of the probabilistic evolution of accident scenarios for a complex system such as a nuclear power plant is not a trivial challenge. The complexity of the system to be modeled leads to demanding computational requirements even to simulate one of the many possible evolutions of an accident scenario (tens of CPU/hour). At the same time, the probabilistic analysis requires thousands of runs to investigate outcomes characterized by low probability and severe consequence (tail problem). The milestone reported in June of 2013 [5] described the capability of RAVEN to implement complex control logic and provide an adequate support for the exploration of the probabilistic space using a Monte Carlo sampling strategy. Unfortunately the Monte Carlo approach is ineffective with a problem of this complexity. In the following year of development, the RAVEN code has been extended with more sophisticated sampling strategies (grids, Latin Hypercube, and adaptive sampling). This milestone report illustrates the effectiveness of those methodologies in performing the assessment of the probability of core damage following the onset of a Station Black Out (SBO) situation in a boiling water reactor (BWR). The first part of the report provides an overview of the available probabilistic analysis capabilities, ranging from the different types of distributions available, possible sampling

  16. Permitting - the latest mining risk

    Energy Technology Data Exchange (ETDEWEB)

    Hume, W.M.; Munn, F.J. [Cardinal River Coals Ltd., Hinton, AB (Canada)

    1995-05-01

    The Cheviot approach to mine permitting and the status of the Cheviot permitting process are described. The mine is the first Canadian metallurgical mine built since the early 1970s and will replace the Luscar Mine. There have been significant changes in the technology of mining equipment and with the requirements for government regulatory approvals since 1980, when the last mines were built. A permit application must be technically complete and must be legally correct. A valid public involvement process must support an application. A permit application is now an entire process that leads to submission and review of a document. Cardinal River Coals is applying two principles in order to meet these objectives: to be technically advanced and show the ability to manage the environment; and to conduct a proactive and effective public involvement program.

  17. Statistical and Hydrological Evaluation of TRMM-Based Multi-Satellite Precipitation Analysis over the Wangchu Basin of Bhutan: Are the Latest Satellite Precipitation Products 3B42V7 Ready for Use in Ungauged Basins?

    Science.gov (United States)

    Xue, Xianwu; Hong, Yang; Limaye, Ashutosh S.; Gourley, Jonathan; Huffman, George J.; Khan, Sadiq Ibrahim; Dorji, Chhimi; Chen, Sheng

    2013-01-01

    The objective of this study is to quantitatively evaluate the successive Tropical Rainfall Measuring Mission (TRMM) Multi-satellite Precipitation Analysis (TMPA) products and further to explore the improvements and error propagation of the latest 3B42V7 algorithm relative to its predecessor 3B42V6 using the Coupled Routing and Excess Storage (CREST) hydrologic model in the mountainous Wangchu Basin of Bhutan. First, the comparison to a decade-long (2001-2010) daily rain gauge dataset reveals that: 1) 3B42V7 generally improves upon 3B42V6s underestimation both for the whole basin (bias from -41.15 to -8.38) and for a 0.250.25 grid cell with high-density gauges (bias from -40.25 to 0.04), though with modest enhancement of correlation coefficients (CC) (from 0.36 to 0.40 for basin-wide and from 0.37 to 0.41 for grid); and 2) 3B42V7 also improves its occurrence frequency across the rain intensity spectrum. Using the CREST model that has been calibrated with rain gauge inputs, the 3B42V6-based simulation shows limited hydrologic prediction NSCE skill (0.23 in daily scale and 0.25 in monthly scale) while 3B42V7 performs fairly well (0.66 in daily scale and 0.77 in monthly scale), a comparable skill score with the gauge rainfall simulations. After recalibrating the model with the respective TMPA data, significant improvements are observed for 3B42V6 across all categories, but not as much enhancement for the already well-performing 3B42V7 except for a reduction in bias (from -26.98 to -4.81). In summary, the latest 3B42V7 algorithm reveals a significant upgrade from 3B42V6 both in precipitation accuracy (i.e., correcting the underestimation) thus improving its potential hydrological utility. Forcing the model with 3B42V7 rainfall yields comparable skill scores with in-situ gauges even without recalibration of the hydrological model by the satellite precipitation, a compensating approach often used but not favored by the hydrology community, particularly in ungauged basins.

  18. Glaucoma: Symptoms, Diagnosis, Treatment and Latest Research

    Science.gov (United States)

    ... page please turn Javascript on. Feature: Glaucoma Glaucoma: Symptoms, Diagnosis, Treatment and Latest Research Past Issues / Fall 2009 Table of Contents Symptoms and Diagnosis Glaucoma can develop in one or ...

  19. The Advanced Traceability and Control System Performance Data Analysis

    Science.gov (United States)

    1992-06-01

    storage for all failed repairable managed in the Navy system. One supply analyst, Mr. Paul Barraco , NAVMTO Code 033B, is assigned to maintain this...base from Mr. Barraco [Ref. 5:p. 57-58]. They had planned to use the tapes to run sample statistics to use in their model. They were unable to do...431A, should be contacted to obtain the latest operating procedures for the ATAC system. If additional data is required Mr. Paul Barraco , NAVMTO

  20. Recent advances in (soil moisture) triple collocation analysis

    Science.gov (United States)

    Gruber, A.; Su, C.-H.; Zwieback, S.; Crow, W.; Dorigo, W.; Wagner, W.

    2016-03-01

    To date, triple collocation (TC) analysis is one of the most important methods for the global-scale evaluation of remotely sensed soil moisture data sets. In this study we review existing implementations of soil moisture TC analysis as well as investigations of the assumptions underlying the method. Different notations that are used to formulate the TC problem are shown to be mathematically identical. While many studies have investigated issues related to possible violations of the underlying assumptions, only few TC modifications have been proposed to mitigate the impact of these violations. Moreover, assumptions, which are often understood as a limitation that is unique to TC analysis are shown to be common also to other conventional performance metrics. Noteworthy advances in TC analysis have been made in the way error estimates are being presented by moving from the investigation of absolute error variance estimates to the investigation of signal-to-noise ratio (SNR) metrics. Here we review existing error presentations and propose the combined investigation of the SNR (expressed in logarithmic units), the unscaled error variances, and the soil moisture sensitivities of the data sets as an optimal strategy for the evaluation of remotely-sensed soil moisture data sets.

  1. Conceptual study of advanced PWR core design. Development of advanced PWR core neutronics analysis system

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Chang Hyo; Kim, Seung Cho; Kim, Taek Kyum; Cho, Jin Young; Lee, Hyun Cheol; Lee, Jung Hun; Jung, Gu Young [Seoul National University, Seoul (Korea, Republic of)

    1995-08-01

    The neutronics design system of the advanced PWR consists of (i) hexagonal cell and fuel assembly code for generation of homogenized few-group cross sections and (ii) global core neutronics analysis code for computations of steady-state pin-wise or assembly-wise core power distribution, core reactivity with fuel burnup, control rod worth and reactivity coefficients, transient core power, etc.. The major research target of the first year is to establish the numerical method and solution of multi-group diffusion equations for neutronics code development. Specifically, the following studies are planned; (i) Formulation of various numerical methods such as finite element method(FEM), analytical nodal method(ANM), analytic function expansion nodal(AFEN) method, polynomial expansion nodal(PEN) method that can be applicable for the hexagonal core geometry. (ii) Comparative evaluation of the numerical effectiveness of these methods based on numerical solutions to various hexagonal core neutronics benchmark problems. Results are follows: (i) Formulation of numerical solutions to multi-group diffusion equations based on numerical methods. (ii) Numerical computations by above methods for the hexagonal neutronics benchmark problems such as -VVER-1000 Problem Without Reflector -VVER-440 Problem I With Reflector -Modified IAEA PWR Problem Without Reflector -Modified IAEA PWR Problem With Reflector -ANL Large Heavy Water Reactor Problem -Small HTGR Problem -VVER-440 Problem II With Reactor (iii) Comparative evaluation on the numerical effectiveness of various numerical methods. (iv) Development of HEXFEM code, a multi-dimensional hexagonal core neutronics analysis code based on FEM. In the target year of this research, the spatial neutronics analysis code for hexagonal core geometry(called NEMSNAP-H temporarily) will be completed. Combination of NEMSNAP-H with hexagonal cell and assembly code will then equip us with hexagonal core neutronics design system. (Abstract Truncated)

  2. Latest insights on adenovirus structure and assembly.

    Science.gov (United States)

    San Martín, Carmen

    2012-05-01

    Adenovirus (AdV) capsid organization is considerably complex, not only because of its large size (~950 Å) and triangulation number (pseudo T = 25), but also because it contains four types of minor proteins in specialized locations modulating the quasi-equivalent icosahedral interactions. Up until 2009, only its major components (hexon, penton, and fiber) had separately been described in atomic detail. Their relationships within the virion, and the location of minor coat proteins, were inferred from combining the known crystal structures with increasingly more detailed cryo-electron microscopy (cryoEM) maps. There was no structural information on assembly intermediates. Later on that year, two reports described the structural differences between the mature and immature adenoviral particle, starting to shed light on the different stages of viral assembly, and giving further insights into the roles of core and minor coat proteins during morphogenesis [1,2]. Finally, in 2010, two papers describing the atomic resolution structure of the complete virion appeared [3,4]. These reports represent a veritable tour de force for two structural biology techniques: X-ray crystallography and cryoEM, as this is the largest macromolecular complex solved at high resolution by either of them. In particular, the cryoEM analysis provided an unprecedented clear picture of the complex protein networks shaping the icosahedral shell. Here I review these latest developments in the field of AdV structural studies.

  3. Latest Insights on Adenovirus Structure and Assembly

    Directory of Open Access Journals (Sweden)

    Carmen San Martín

    2012-05-01

    Full Text Available Adenovirus (AdV capsid organization is considerably complex, not only because of its large size (~950 Å and triangulation number (pseudo T = 25, but also because it contains four types of minor proteins in specialized locations modulating the quasi-equivalent icosahedral interactions. Up until 2009, only its major components (hexon, penton, and fiber had separately been described in atomic detail. Their relationships within the virion, and the location of minor coat proteins, were inferred from combining the known crystal structures with increasingly more detailed cryo-electron microscopy (cryoEM maps. There was no structural information on assembly intermediates. Later on that year, two reports described the structural differences between the mature and immature adenoviral particle, starting to shed light on the different stages of viral assembly, and giving further insights into the roles of core and minor coat proteins during morphogenesis [1,2]. Finally, in 2010, two papers describing the atomic resolution structure of the complete virion appeared [3,4]. These reports represent a veritable tour de force for two structural biology techniques: X-ray crystallography and cryoEM, as this is the largest macromolecular complex solved at high resolution by either of them. In particular, the cryoEM analysis provided an unprecedented clear picture of the complex protein networks shaping the icosahedral shell. Here I review these latest developments in the field of AdV structural studies.

  4. Latest news from the Tiles

    CERN Multimedia

    Costanzo, D

    The Tile hadronic calorimeter will be installed in the central region of ATLAS with an inner radius of 2.28 m, an outer radius of 4.25 m, a total length of about 12 m and a weight of about 2300 tons. The calorimeter is mechanically divided in one central barrel and two extended barrels, with a gap in between for the services of the internal part of ATLAS. The construction of the calorimeter is advanced, and installation in the ATLAS pit is foreseen to start in December 2003. After mechanical assembly the modules are instrumented with all the optical components. Scintillating tiles are inserted into the slots, and the read-out Wave Length Shifting fibers are coupled to scintillators and bundled to achieve the quasi-projective cell geometry of the calorimeter. The final modules are stored in bldg 185, shown in the first photo, and in bldg 175 at CERN. The barrel modules are mechanically assembled in Dubna and then transported to CERN to be optically instrumented, while the extended barrels are constructed in t...

  5. The latest from the LHC

    CERN Multimedia

    2009-01-01

    The consolidation campaign, managed by the Quench Protection team, is advancing well. Phase 1 of the campaign is focused on the new protection system designed to monitor the superconducting busbars. This system will be able to detect tiny electrical resistances on these busbars, similar to the one that caused the incident in Sector 3-4. Following completion of the design of the two principal electronics boards, the first order for 2500 and 500 such boards will be placed this week. The manufacture of the cable segments for the first three LHC sectors is going ahead, and the installation programme has already begun in Sector 4-5. In total, more than 230 km of various types of cables will have to be laid. The complete system will consist of a network of 2132 detectors housed in 436 crates around the machine. These will monitor the interconnections of the main dipoles and quadrupoles in the three major circuits. The detectors will precisely measure the electrical resistance of each busbar segment, including the ...

  6. 感冒中医药诊治最新研究进展%The Latest Advance in the Research of Traditional Chinese Medicine Diagnosis and Treatment on Common Cold and Influenza

    Institute of Scientific and Technical Information of China (English)

    王成阳; 李泽庚

    2012-01-01

    人们近年对感冒有更深认识,在感冒病名分类、病因病机、辨证治疗、药物研究上有进展性突破.区分中西感冒,统一命名分类;鉴别感冒寒温,阐明病因痛机,引入“隐类分析法”.辨证另辟蹊径,论治更重综合,体现在“从息论态”及对感冒的多维诊治.科技、政策推动国内外感冒中药研究.不足在于偏“时行”、少“普通”,对古验方研究乏深度,动物模型、证本质等方面的循证有待规范拓展,有价值基础研究进展缓慢.%In recent years, people have had a deeper understanding of the common cold and influenza and made progress or breakthroughs on research of disease name and classification, etiology and pathogenesis, dialectical therapy, and drug research. Specifically, these can be reflected from the following points; to unify the naming and classification by distinguishing between the Chinese and Western cold, to clarify the etiology and pathogenesis of cold by comparing the febrile disease of Traditional Chinese Medicine and warm disease and by introducing the special method of statistical analysis, to open a new path in the dialectical process and to treat in a comprehensive approach which embodied in the "recognizing state from information" and the multidimensional diagnosis and treatment of cold. In addition, the science, technology, and policy together at home and abroad has promoted the, reach trend of Chinese medicine on treating the cold.However, there are still inadequacies.For example, too much emphasis are given to the research of influenza, and therefore the common cold was ignored.Morever, the study of ancient prescription are somewhat superficial, evdence-hased research on animal model and syndrome essence need to be standardized and expanded urgently.Still, valuable bask- research has progress ed snail-pacedly over the past years.

  7. Thermodynamic analysis of the advanced zero emission power plant

    Directory of Open Access Journals (Sweden)

    Kotowicz Janusz

    2016-03-01

    Full Text Available The paper presents the structure and parameters of advanced zero emission power plant (AZEP. This concept is based on the replacement of the combustion chamber in a gas turbine by the membrane reactor. The reactor has three basic functions: (i oxygen separation from the air through the membrane, (ii combustion of the fuel, and (iii heat transfer to heat the oxygen-depleted air. In the discussed unit hot depleted air is expanded in a turbine and further feeds a bottoming steam cycle (BSC through the main heat recovery steam generator (HRSG. Flue gas leaving the membrane reactor feeds the second HRSG. The flue gas consist mainly of CO2 and water vapor, thus, CO2 separation involves only the flue gas drying. Results of the thermodynamic analysis of described power plant are presented.

  8. Review on recent advances in the analysis of isolated organelles

    Energy Technology Data Exchange (ETDEWEB)

    Satori, Chad P. [Department of Chemistry, University of Minnesota, Minneapolis, MN 55455 (United States); Kostal, Vratislav [Department of Chemistry, University of Minnesota, Minneapolis, MN 55455 (United States); Institute of Analytical Chemistry, Academy of Sciences of the Czech Republic, Brno 616 00 (Czech Republic); Arriaga, Edgar A., E-mail: arriaga@umn.edu [Department of Chemistry, University of Minnesota, Minneapolis, MN 55455 (United States)

    2012-11-13

    Highlights: Black-Right-Pointing-Pointer Advancements in organelle release. Black-Right-Pointing-Pointer New approaches to fractionate organelles. Black-Right-Pointing-Pointer Updates on new techniques to characterize isolated organelles. - Abstract: The analysis of isolated organelles is one of the pillars of modern bioanalytical chemistry. This review describes recent developments on the isolation and characterization of isolated organelles both from living organisms and cell cultures. Salient reports on methods to release organelles focused on reproducibility and yield, membrane isolation, and integrated devices for organelle release. New developments on organelle fractionation after their isolation were on the topics of centrifugation, immunocapture, free flow electrophoresis, flow field-flow fractionation, fluorescence activated organelle sorting, laser capture microdissection, and dielectrophoresis. New concepts on characterization of isolated organelles included atomic force microscopy, optical tweezers combined with Raman spectroscopy, organelle sensors, flow cytometry, capillary electrophoresis, and microfluidic devices.

  9. Analysis of biofluids by paper spray MS: advances and challenges.

    Science.gov (United States)

    Manicke, Nicholas E; Bills, Brandon J; Zhang, Chengsen

    2016-03-01

    Paper spray MS is part of a cohort of ambient ionization or direct analysis methods that seek to analyze complex samples without prior sample preparation. Extraction and electrospray ionization occur directly from the paper substrate upon which a dried matrix spot is stored. Paper spray MS is capable of detecting drugs directly from dried blood, plasma and urine spots at the low ng/ml to pg/ml levels without sample preparation. No front end separation is performed, so MS/MS or high-resolution MS is required. Here, we discuss paper spray methodology, give a comprehensive literature review of the use of paper spray MS for bioanalysis, discuss technological advancements and variations on this technique and discuss some of its limitations.

  10. Thermodynamic analysis of the advanced zero emission power plant

    Science.gov (United States)

    Kotowicz, Janusz; Job, Marcin

    2016-03-01

    The paper presents the structure and parameters of advanced zero emission power plant (AZEP). This concept is based on the replacement of the combustion chamber in a gas turbine by the membrane reactor. The reactor has three basic functions: (i) oxygen separation from the air through the membrane, (ii) combustion of the fuel, and (iii) heat transfer to heat the oxygen-depleted air. In the discussed unit hot depleted air is expanded in a turbine and further feeds a bottoming steam cycle (BSC) through the main heat recovery steam generator (HRSG). Flue gas leaving the membrane reactor feeds the second HRSG. The flue gas consist mainly of CO2 and water vapor, thus, CO2 separation involves only the flue gas drying. Results of the thermodynamic analysis of described power plant are presented.

  11. Systems analysis and futuristic designs of advanced biofuel factory concepts.

    Energy Technology Data Exchange (ETDEWEB)

    Chianelli, Russ; Leathers, James; Thoma, Steven George; Celina, Mathias Christopher; Gupta, Vipin P.

    2007-10-01

    The U.S. is addicted to petroleum--a dependency that periodically shocks the economy, compromises national security, and adversely affects the environment. If liquid fuels remain the main energy source for U.S. transportation for the foreseeable future, the system solution is the production of new liquid fuels that can directly displace diesel and gasoline. This study focuses on advanced concepts for biofuel factory production, describing three design concepts: biopetroleum, biodiesel, and higher alcohols. A general schematic is illustrated for each concept with technical description and analysis for each factory design. Looking beyond current biofuel pursuits by industry, this study explores unconventional feedstocks (e.g., extremophiles), out-of-favor reaction processes (e.g., radiation-induced catalytic cracking), and production of new fuel sources traditionally deemed undesirable (e.g., fusel oils). These concepts lay the foundation and path for future basic science and applied engineering to displace petroleum as a transportation energy source for good.

  12. Burnout prediction using advance image analysis coal characterization techniques

    Energy Technology Data Exchange (ETDEWEB)

    Edward Lester; Dave Watts; Michael Cloke [University of Nottingham, Nottingham (United Kingdom). School of Chemical Environmental and Mining Engineering

    2003-07-01

    The link between petrographic composition and burnout has been investigated previously by the authors. However, these predictions were based on 'bulk' properties of the coal, including the proportion of each maceral or the reflectance of the macerals in the whole sample. Combustion studies relating burnout with microlithotype analysis, or similar, remain less common partly because the technique is more complex than maceral analysis. Despite this, it is likely that any burnout prediction based on petrographic characteristics will become more accurate if it includes information about the maceral associations and the size of each particle. Chars from 13 coals, 106-125 micron size fractions, were prepared using a Drop Tube Furnace (DTF) at 1300{degree}C and 200 millisecond and 1% Oxygen. These chars were then refired in the DTF at 1300{degree}C 5% oxygen and residence times of 200, 400 and 600 milliseconds. The progressive burnout of each char was compared with the characteristics of the initial coals. This paper presents an extension of previous studies in that it relates combustion behaviour to coals that have been characterized on a particle by particle basis using advanced image analysis techniques. 13 refs., 7 figs.

  13. Latest advances in soft X-ray spectromicroscopy at SSRF

    Institute of Scientific and Technical Information of China (English)

    张立娟; 李俊琴; 陈振华; 王勇; 邰仁忠; 许子健; 张祥志; 于怀娜; 邹鹰; 郭智; 甄香君; 曹杰峰; 孟祥雨

    2015-01-01

    The BL08U1A beamline is established as a sophisticated platform at Shanghai Synchrotron Radiation Facility (SSRF), taking advantage of its high spatial resolution (10 000), for studying properties of solid, liquid, gas, film and other forms of materials at sub-micron scale. In this paper, we present a review on newly implemented techniques, such as total electron yield (TEY), dual energy contrast imaging, nano-CT, soft X-ray excited optical luminance (SXEOL), and coherent diffraction imaging (CDI) under development. Several research cases in nanomaterials, environmental science and biology are presented to demonstrate capabilities of the beamline.

  14. Lock Acquisition and Sensitivity Analysis of Advanced LIGO Interferometers

    Science.gov (United States)

    Martynov, Denis

    Laser interferometer gravitational wave observatory (LIGO) consists of two complex large-scale laser interferometers designed for direct detection of gravitational waves from distant astrophysical sources in the frequency range 10Hz - 5kHz. Direct detection of space-time ripples will support Einstein's general theory of relativity and provide invaluable information and new insight into physics of the Universe. The initial phase of LIGO started in 2002, and since then data was collected during the six science runs. Instrument sensitivity improved from run to run due to the effort of commissioning team. Initial LIGO has reached designed sensitivity during the last science run, which ended in October 2010. In parallel with commissioning and data analysis with the initial detector, LIGO group worked on research and development of the next generation of detectors. Major instrument upgrade from initial to advanced LIGO started in 2010 and lasted until 2014. This thesis describes results of commissioning work done at the LIGO Livingston site from 2013 until 2015 in parallel with and after the installation of the instrument. This thesis also discusses new techniques and tools developed at the 40m prototype including adaptive filtering, estimation of quantization noise in digital filters and design of isolation kits for ground seismometers. The first part of this thesis is devoted to the description of methods for bringing the interferometer into linear regime when collection of data becomes possible. States of longitudinal and angular controls of interferometer degrees of freedom during lock acquisition process and in low noise configuration are discussed in details. Once interferometer is locked and transitioned to low noise regime, instrument produces astrophysics data that should be calibrated to units of meters or strain. The second part of this thesis describes online calibration technique set up in both observatories to monitor the quality of the collected data in

  15. Advanced High Temperature Reactor Systems and Economic Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Holcomb, David Eugene [ORNL; Peretz, Fred J [ORNL; Qualls, A L [ORNL

    2011-09-01

    The Advanced High Temperature Reactor (AHTR) is a design concept for a large-output [3400 MW(t)] fluoride-salt-cooled high-temperature reactor (FHR). FHRs, by definition, feature low-pressure liquid fluoride salt cooling, coated-particle fuel, a high-temperature power cycle, and fully passive decay heat rejection. The AHTR's large thermal output enables direct comparison of its performance and requirements with other high output reactor concepts. As high-temperature plants, FHRs can support either high-efficiency electricity generation or industrial process heat production. The AHTR analysis presented in this report is limited to the electricity generation mission. FHRs, in principle, have the potential to be low-cost electricity producers while maintaining full passive safety. However, no FHR has been built, and no FHR design has reached the stage of maturity where realistic economic analysis can be performed. The system design effort described in this report represents early steps along the design path toward being able to predict the cost and performance characteristics of the AHTR as well as toward being able to identify the technology developments necessary to build an FHR power plant. While FHRs represent a distinct reactor class, they inherit desirable attributes from other thermal power plants whose characteristics can be studied to provide general guidance on plant configuration, anticipated performance, and costs. Molten salt reactors provide experience on the materials, procedures, and components necessary to use liquid fluoride salts. Liquid metal reactors provide design experience on using low-pressure liquid coolants, passive decay heat removal, and hot refueling. High temperature gas-cooled reactors provide experience with coated particle fuel and graphite components. Light water reactors (LWRs) show the potentials of transparent, high-heat capacity coolants with low chemical reactivity. Modern coal-fired power plants provide design experience

  16. Quantitative Computed Tomography and image analysis for advanced muscle assessment

    Directory of Open Access Journals (Sweden)

    Kyle Joseph Edmunds

    2016-06-01

    Full Text Available Medical imaging is of particular interest in the field of translational myology, as extant literature describes the utilization of a wide variety of techniques to non-invasively recapitulate and quantity various internal and external tissue morphologies. In the clinical context, medical imaging remains a vital tool for diagnostics and investigative assessment. This review outlines the results from several investigations on the use of computed tomography (CT and image analysis techniques to assess muscle conditions and degenerative process due to aging or pathological conditions. Herein, we detail the acquisition of spiral CT images and the use of advanced image analysis tools to characterize muscles in 2D and 3D. Results from these studies recapitulate changes in tissue composition within muscles, as visualized by the association of tissue types to specified Hounsfield Unit (HU values for fat, loose connective tissue or atrophic muscle, and normal muscle, including fascia and tendon. We show how results from these analyses can be presented as both average HU values and compositions with respect to total muscle volumes, demonstrating the reliability of these tools to monitor, assess and characterize muscle degeneration.

  17. Ultra Wideband Indoor Positioning Technologies: Analysis and Recent Advances.

    Science.gov (United States)

    Alarifi, Abdulrahman; Al-Salman, AbdulMalik; Alsaleh, Mansour; Alnafessah, Ahmad; Al-Hadhrami, Suheer; Al-Ammar, Mai A; Al-Khalifa, Hend S

    2016-05-16

    In recent years, indoor positioning has emerged as a critical function in many end-user applications; including military, civilian, disaster relief and peacekeeping missions. In comparison with outdoor environments, sensing location information in indoor environments requires a higher precision and is a more challenging task in part because various objects reflect and disperse signals. Ultra WideBand (UWB) is an emerging technology in the field of indoor positioning that has shown better performance compared to others. In order to set the stage for this work, we provide a survey of the state-of-the-art technologies in indoor positioning, followed by a detailed comparative analysis of UWB positioning technologies. We also provide an analysis of strengths, weaknesses, opportunities, and threats (SWOT) to analyze the present state of UWB positioning technologies. While SWOT is not a quantitative approach, it helps in assessing the real status and in revealing the potential of UWB positioning to effectively address the indoor positioning problem. Unlike previous studies, this paper presents new taxonomies, reviews some major recent advances, and argues for further exploration by the research community of this challenging problem space.

  18. Ultra Wideband Indoor Positioning Technologies: Analysis and Recent Advances

    Directory of Open Access Journals (Sweden)

    Abdulrahman Alarifi

    2016-05-01

    Full Text Available In recent years, indoor positioning has emerged as a critical function in many end-user applications; including military, civilian, disaster relief and peacekeeping missions. In comparison with outdoor environments, sensing location information in indoor environments requires a higher precision and is a more challenging task in part because various objects reflect and disperse signals. Ultra WideBand (UWB is an emerging technology in the field of indoor positioning that has shown better performance compared to others. In order to set the stage for this work, we provide a survey of the state-of-the-art technologies in indoor positioning, followed by a detailed comparative analysis of UWB positioning technologies. We also provide an analysis of strengths, weaknesses, opportunities, and threats (SWOT to analyze the present state of UWB positioning technologies. While SWOT is not a quantitative approach, it helps in assessing the real status and in revealing the potential of UWB positioning to effectively address the indoor positioning problem. Unlike previous studies, this paper presents new taxonomies, reviews some major recent advances, and argues for further exploration by the research community of this challenging problem space.

  19. Ultra Wideband Indoor Positioning Technologies: Analysis and Recent Advances

    Science.gov (United States)

    Alarifi, Abdulrahman; Al-Salman, AbdulMalik; Alsaleh, Mansour; Alnafessah, Ahmad; Al-Hadhrami, Suheer; Al-Ammar, Mai A.; Al-Khalifa, Hend S.

    2016-01-01

    In recent years, indoor positioning has emerged as a critical function in many end-user applications; including military, civilian, disaster relief and peacekeeping missions. In comparison with outdoor environments, sensing location information in indoor environments requires a higher precision and is a more challenging task in part because various objects reflect and disperse signals. Ultra WideBand (UWB) is an emerging technology in the field of indoor positioning that has shown better performance compared to others. In order to set the stage for this work, we provide a survey of the state-of-the-art technologies in indoor positioning, followed by a detailed comparative analysis of UWB positioning technologies. We also provide an analysis of strengths, weaknesses, opportunities, and threats (SWOT) to analyze the present state of UWB positioning technologies. While SWOT is not a quantitative approach, it helps in assessing the real status and in revealing the potential of UWB positioning to effectively address the indoor positioning problem. Unlike previous studies, this paper presents new taxonomies, reviews some major recent advances, and argues for further exploration by the research community of this challenging problem space. PMID:27196906

  20. Latest results from KLOE-2

    Directory of Open Access Journals (Sweden)

    Bloise Caterina

    2014-01-01

    Full Text Available The KLOE experiment at the Frascati φ–factory recently obtained results on i CPT and Lorentz invariance tests from the study of quantum interference of the neutral kaon pairs; ii precision measurement of the branching fraction, BR(K+ → π+π−π+(γ = 0.05565 ± 0.00031stat ± 0.00025syst, and iii on dark photon searches with the analysis of the e+e− → µµγ final state. We have also studied the transition form factors of the φ meson to the pseudoscalars, π0 and η, that is presented in a separate contribution to this volume.

  1. The latest from the LHC

    CERN Multimedia

    On the surface, a dipole has been fully fitted and tested with a new helium pressure-relief valve. Work will start this week to fit these new devices to the remaining magnets on the surface and by next week the campaign to install the relief valves in situ in the tunnel will start in the warmed-up sectors. In SM18 the cold-testing team have found a new method of testing for internal splice- resistance with 20 times the accuracy of previous methods. They can now measure the individual splice resistance to 1 nano-ohm. A massive campaign has also been launched to re-analyse data taken from all superconducting magnets that have already gone through cold testing but were not checked for abnormal splice-resistance. By combining two different sets of data taken for other purposes during the magnet cold-testing the new analysis will be able to infer if there was any abnormal internal resistance. The work is being carried out by a collaboration of the TE, EN and PH departments. During the incident in sector 3-4 th...

  2. The latest from the LHC

    CERN Multimedia

    2009-01-01

    The LHC will run with an energy of 3.5 TeV per beam when it starts up in November this year. The 80 K resistance measurements on the copper stabilizer of the superconducting busbars were completed in the remaining sectors, Sectors 8-1 and 2-3. No abnormally high resistance measurements were found, indicating that no further repairs are necessary for safe running. Detailed analysis of the resistance data from the entire ring determined a safe initial energy of 3.5 TeV per beam. Once a significant data sample has been collected and the operations team has gained experience in running the machine, the energy will be taken towards 5 TeV per beam. More information is available in the recent press release http://press.web.cern.ch/press/PressReleases/Releases2009/PR13.09E.html. Following the helium leaks into the insulation vacuum in Sectors 2-3 and 8-1 (see previous update) the cause of the leak in Sector 2-3 has been confirmed as the flexible hose. This has now been replaced...

  3. Advancing sensitivity analysis to precisely characterize temporal parameter dominance

    Science.gov (United States)

    Guse, Björn; Pfannerstill, Matthias; Strauch, Michael; Reusser, Dominik; Lüdtke, Stefan; Volk, Martin; Gupta, Hoshin; Fohrer, Nicola

    2016-04-01

    Parameter sensitivity analysis is a strategy for detecting dominant model parameters. A temporal sensitivity analysis calculates daily sensitivities of model parameters. This allows a precise characterization of temporal patterns of parameter dominance and an identification of the related discharge conditions. To achieve this goal, the diagnostic information as derived from the temporal parameter sensitivity is advanced by including discharge information in three steps. In a first step, the temporal dynamics are analyzed by means of daily time series of parameter sensitivities. As sensitivity analysis method, we used the Fourier Amplitude Sensitivity Test (FAST) applied directly onto the modelled discharge. Next, the daily sensitivities are analyzed in combination with the flow duration curve (FDC). Through this step, we determine whether high sensitivities of model parameters are related to specific discharges. Finally, parameter sensitivities are separately analyzed for five segments of the FDC and presented as monthly averaged sensitivities. In this way, seasonal patterns of dominant model parameter are provided for each FDC segment. For this methodical approach, we used two contrasting catchments (upland and lowland catchment) to illustrate how parameter dominances change seasonally in different catchments. For all of the FDC segments, the groundwater parameters are dominant in the lowland catchment, while in the upland catchment the controlling parameters change seasonally between parameters from different runoff components. The three methodical steps lead to clear temporal patterns, which represent the typical characteristics of the study catchments. Our methodical approach thus provides a clear idea of how the hydrological dynamics are controlled by model parameters for certain discharge magnitudes during the year. Overall, these three methodical steps precisely characterize model parameters and improve the understanding of process dynamics in hydrological

  4. 2nd International Conference on Recent Advances in Information Technology

    CERN Document Server

    Mukhopadhyay, Sushanta

    2014-01-01

    The book is based on the research papers presented in Second International Conference on Recent Advances in Information Technology (RAIT 2014), held at Indian School of Mines, Dhanbad, India. It provides the latest developments in the area of information technology and covers a variety of topics, including Advanced Algorithm Design and Analysis, Algorithmic Graph Theory, Artificial Intelligence, Bioinformatics, Circuit Design Automation, Computational Biology, Computational Mathematics, Cryptology, Data Compression, Database Management System, Data Mining, E-Applications, Embedded System, Information and Network Security, Information Retrieval, Internet Computing, etc. The objective is to familiarize the reader with the latest scientific developments that are taking place in various fields and the latest sophisticated problem solving tools that are being developed to deal with the complex and intricate problems that are otherwise difficult to solve by the usual and traditional methods.

  5. Global Energy and Water Balances in the Latest Reanalyses

    Science.gov (United States)

    Ahn, Joong-Bae; Kang, Suchul; Park, Hye-Jin

    2016-04-01

    The recently released Japanese 55-year Reanalysis (JRA-55) data are evaluated and compared with three other global reanalyses, namely Interim version of the next European Centre for Medium-Range Weather Forecasts (ECMWF) Re-Analysis (ERRA-Interim), Modern Era Retrospective-Analysis for Research and Applications (MERRA) and Climate Forecast System Reanalysis (CFSR), in terms of global energy and water balances. All four reanalyses show an energy imbalance at TOA and surface. Especially, clouds in JRA-55 are optically weaker than those in the three other reanalyses, leading to excessive outgoing longwave radiation, which in turn causes negative net energy flux at TOA. Moreover, JRA-55 has a negative imbalance at surface and at TOA, which is attributed to systematic positive biases in latent heat flux over the ocean. As for the global water balance, all reanalyses present a similar spatial pattern of the difference between evaporation and precipitation (E-P). However, JRA-55 has a relatively strong negative (positive) E-P in the Intertropical Convergence Zone and South Pacific Convergence Zone (extratropical regions) due to overestimated precipitation (evaporation), in spite of the global net being close to zero. In time series analysis, especially in E-P, significant stepwise changes occur in MERRA, CFSR and ERA-Interim due to the changes occur in MERRA, CFRS and ERA-Interim due to the changes in the satellite observing system used in the data assimilation. Both MERRA and CFSR show a strong downward E-P shift in 1998, simultaneously with the start of the assimilation of AMSU-A sounding radiances. ERA-Interim exhibits an upward E-P shift in 1992 due to changes in observations from the SSM/I of new DMSP satellites. On the contrary, JRA-55 exhibits less trends and remains stable over time, which may be caused by newly available, homogenized observations and advances in data assimilation technique. Acknowledgements This work was funded by the Korea Meteorological

  6. Economics of coal conversion processing. Advances in coal gasification: support research. Advances in coal gasification: process development and analysis

    Energy Technology Data Exchange (ETDEWEB)

    1978-01-01

    The fall meeting of the American Chemical Society, Division of Fuel Chemistry, was held at Miami Beach, Florida, September 10-15, 1978. Papers involved the economics of coal conversion processing and advances in coal gasification, especially support research and process development and analysis. Fourteen papers have been entered individually into EDB and ERA; three papers had been entered previously from other sources. (LTN)

  7. Advances in the analysis of iminocyclitols: Methods, sources and bioavailability.

    Science.gov (United States)

    Amézqueta, Susana; Torres, Josep Lluís

    2016-05-01

    Iminocyclitols are chemically and metabolically stable, naturally occurring sugar mimetics. Their biological activities make them interesting and extremely promising as both drug leads and functional food ingredients. The first iminocyclitols were discovered using preparative isolation and purification methods followed by chemical characterization using nuclear magnetic resonance spectroscopy. In addition to this classical approach, gas and liquid chromatography coupled to mass spectrometry are increasingly used; they are highly sensitive techniques capable of detecting minute amounts of analytes in a broad spectrum of sources after only minimal sample preparation. These techniques have been applied to identify new iminocyclitols in plants, microorganisms and synthetic mixtures. The separation of iminocyclitol mixtures by chromatography is particularly difficult however, as the most commonly used matrices have very low selectivity for these highly hydrophilic structurally similar molecules. This review critically summarizes recent advances in the analysis of iminocyclitols from plant sources and findings regarding their quantification in dietary supplements and foodstuffs, as well as in biological fluids and organs, from bioavailability studies.

  8. Steam Methane Reforming System for Hydrogen Production: Advanced Exergetic Analysis

    Directory of Open Access Journals (Sweden)

    Tatiana Morosuk

    2012-02-01

    Full Text Available Steam methane reforming (SMR is one of the most promising processes for the production of hydrogen. Therefore, the overall thermodynamic efficiency of this process is of particular importance. The thermodynamic inefficiencies in a thermal system are related to exergy destruction and exergy loss. However, a conventional exergetic analysis cannot evaluate the mutual interdependencies among the system components nor the real potential for improving the energy conversion system being considered. One of the tools under development for the improvement of energy conversion systems from the thermodynamic viewpoint is the advanced exergetic analysis. In this paper, the avoidable part of the exergy destruction is estimated and the interactions among components of the overall system are evaluated in terms of endogenous and exogenous exergy destruction. The assumptions required for these calculations are discussed in detail, especially for those components that are typically used in chemical processes. Results of this paper suggest options for increasing the thermodynamic efficiency of hydrogen production by steam-methane reforming.

  9. Thermoeconomic Analysis of Advanced Solar-Fossil Combined Power Plants

    Directory of Open Access Journals (Sweden)

    Yassine Allani

    2000-12-01

    Full Text Available

    Hybrid solar thermal power plants (with parabolic trough type of solar collectors featuring gas burners and Rankine steam cycles have been successfully demonstrated by California's Solar Electric Generating System (SEGS. This system has been proven to be one of the most efficient and economical schemes to convert solar energy into electricity. Recent technological progress opens interesting prospects for advanced cycle concepts: a the ISCCS (Integrated Solar Combined Cycle System that integrates the parabolic trough into a fossil fired combined cycle, which allows a larger exergy potential of the fuel to be converted. b the HSTS (Hybrid Solar Tower System which uses high concentration optics (via a power tower generator and high temperature air receivers to drive the combined cycle power plant. In the latter case, solar energy is used at a higher exergy level as a heat source of the topping cycle. This paper presents the results of a thermoeconomic investigation of an ISCCS envisaged in Tunisia. The study is realized in two phases. In the first phase, a mixed approach, based on pinch technology principles coupled with a mathematical optimization algorithm, is used to minimize the heat transfer exergy losses in the steam generators, respecting the off design operating conditions of the steam turbine (cone law. In the second phase, an economic analysis based on the Levelized Electricity Cost (LEC approach was carried out for the configurations, which provided the best concepts during the first phase. A comparison of ISCCS with pure fossil fueled plants (CC+GT is reported for the same electrical power load. A sensitivity analysis based on the relative size of the solar field is presented.

    •  This paper was presented at the ECOS'00 Conference in Enschede, July 5-7, 2000

  10. Meta-Analysis and Advancement of Brucellosis Vaccinology

    Science.gov (United States)

    Carvalho, Tatiane F.; Haddad, João Paulo A.; Paixão, Tatiane A.

    2016-01-01

    Background/Objectives In spite of all the research effort for developing new vaccines against brucellosis, it remains unclear whether these new vaccine technologies will in fact become widely used. The goal of this study was to perform a meta-analysis to identify parameters that influence vaccine efficacy as well as a descriptive analysis on how the field of Brucella vaccinology is advancing concerning type of vaccine, improvement of protection on animal models over time, and factors that may affect protection in the mouse model. Methods A total of 117 publications that met the criteria were selected for inclusion in this study, with a total of 782 individual experiments analyzed. Results Attenuated (n = 221), inactivated (n = 66) and mutant (n = 102) vaccines provided median protection index above 2, whereas subunit (n = 287), DNA (n = 68), and vectored (n = 38) vaccines provided protection indexes lower than 2. When all categories of experimental vaccines are analyzed together, the trend line clearly demonstrates that there was no improvement of the protection indexes over the past 30 years, with a low negative and non significant linear coefficient. A meta-regression model was developed including all vaccine categories (attenuated, DNA, inactivated, mutant, subunit, and vectored) considering the protection index as a dependent variable and the other parameters (mouse strain, route of vaccination, number of vaccinations, use of adjuvant, challenge Brucella species) as independent variables. Some of these variables influenced the expected protection index of experimental vaccines against Brucella spp. in the mouse model. Conclusion In spite of the large number of publication over the past 30 years, our results indicate that there is not clear trend to improve the protective potential of these experimental vaccines. PMID:27846274

  11. Differential equations and applications recent advances

    CERN Document Server

    2014-01-01

    Differential Equations and Applications : Recent Advances focus on the latest developments in Nonlinear Dynamical Systems, Neural Networks, Fluid Dynamics, Fractional Differential Systems, Mathematical Modelling and Qualitative Theory. Different aspects such as Existence, Stability, Controllability, Viscosity and Numerical Analysis for different systems have been discussed in this book. This book will be of great interest and use to researchers in Applied Mathematics, Engineering and Mathematical Physics.

  12. Advancing our thinking in presence-only and used-available analysis

    NARCIS (Netherlands)

    Warton, D.; Aarts, G.M.

    2013-01-01

    1. The problems of analysing used-available data and presence-only data are equivalent, and this paper uses this equivalence as a platform for exploring opportunities for advancing analysis methodology. 2. We suggest some potential methodological advances in used-available analysis, made possible vi

  13. Advanced waveform decomposition for high-speed videoendoscopy analysis.

    Science.gov (United States)

    Ikuma, Takeshi; Kunduk, Melda; McWhorter, Andrew J

    2013-05-01

    This article presents a novel approach to analyze nonperiodic vocal fold behavior of high-speed videoendoscopy (HSV) data. Although HSV can capture true vibrational motions of the vocal folds, its clinical advantage over the videostroboscopy has not widely been accepted. One of the key advantages of the HSV over the videostroboscopy is its ability to capture vocal folds' nonperiodic behavior, which is more prominent in pathological vocal folds. However, such nonperiodicity in the HSV data has not been fully explored quantitatively beyond simple perturbation analysis. This article presents an advanced waveform modeling and decomposition technique for HSV-based waveforms. Waveforms are modeled to have three components: harmonic signal, deterministic nonharmonic signal, and random nonharmonic signal. This decomposition is motivated by the fact that voice disorders introduce signal content that is nonharmonic but carries deterministic quality such as subharmonic or modulating content. The proposed model is aimed to isolate such disordered behaviors as deterministic nonharmonic signal and quantify them. In addition to the model, the article outlines model parameter estimation procedures and a family of harmonics-to-noise ratio (HNR) parameters. The proposed HNR parameters include harmonics-to-deterministic-noise ratio (HDNR) and harmonics-to-random-noise ratio. A preliminary study demonstrates the effectiveness of the extended model and its HNR parameters. Vocal folds with and without benign lesions (Nwith = 13; Nwithout = 20) were studied with HSV glottal area waveforms. All three HNR parameters significantly distinguished the disordered condition, and the HDNR reported the largest effect size (Cohen's d = 2.04).

  14. Advancing Risk Analysis for Nanoscale Materials: Report from an International Workshop on the Role of Alternative Testing Strategies for Advancement: Advancing Risk Analysis for Nanoscale Materials

    Energy Technology Data Exchange (ETDEWEB)

    Shatkin, J. A. [Vireo Advisors, Boston MA USA; Ong, Kimberly J. [Vireo Advisors, Boston MA USA; Beaudrie, Christian [Compass RM, Vancouver CA USA; Clippinger, Amy J. [PETA International Science Consortium Ltd, London UK; Hendren, Christine Ogilvie [Center for the Environmental Implications of NanoTechnology, Duke University, Durham NC USA; Haber, Lynne T. [TERA, Cincinnati OH USA; Hill, Myriam [Health Canada, Ottawa Canada; Holden, Patricia [UC Santa Barbara, Bren School of Environmental Science & Management, ERI, and UC CEIN, University of California, Santa Barbara CA USA; Kennedy, Alan J. [U.S. Army Engineer Research and Development Center, Environmental Laboratory, Vicksburg MS USA; Kim, Baram [Independent, Somerville MA USA; MacDonell, Margaret [Argonne National Laboratory, Environmental Science Division, Argonne IL USA; Powers, Christina M. [U.S. Environmental Protection Agency, Office of Air and Radiation, Office of Transportation and Air Quality, Ann Arbor MI USA; Sharma, Monita [PETA International Science Consortium Ltd, London UK; Sheremeta, Lorraine [Alberta Ingenuity Labs, Edmonton Alberta Canada; Stone, Vicki [John Muir Building Gait 1 Heriot-Watt University, Edinburgh Scotland UK; Sultan, Yasir [Environment Canada, Gatineau QC Canada; Turley, Audrey [ICF International, Durham NC USA; White, Ronald H. [RH White Consultants, Silver Spring MD USA

    2016-08-01

    The Society for Risk Analysis (SRA) has a history of bringing thought leadership to topics of emerging risk. In September 2014, the SRA Emerging Nanoscale Materials Specialty Group convened an international workshop to examine the use of alternative testing strategies (ATS) for manufactured nanomaterials (NM) from a risk analysis perspective. Experts in NM environmental health and safety, human health, ecotoxicology, regulatory compliance, risk analysis, and ATS evaluated and discussed the state of the science for in vitro and other alternatives to traditional toxicology testing for NM. Based on this review, experts recommended immediate and near-term actions that would advance ATS use in NM risk assessment. Three focal areas-human health, ecological health, and exposure considerations-shaped deliberations about information needs, priorities, and the next steps required to increase confidence in and use of ATS in NM risk assessment. The deliberations revealed that ATS are now being used for screening, and that, in the near term, ATS could be developed for use in read-across or categorization decision making within certain regulatory frameworks. Participants recognized that leadership is required from within the scientific community to address basic challenges, including standardizing materials, protocols, techniques and reporting, and designing experiments relevant to real-world conditions, as well as coordination and sharing of large-scale collaborations and data. Experts agreed that it will be critical to include experimental parameters that can support the development of adverse outcome pathways. Numerous other insightful ideas for investment in ATS emerged throughout the discussions and are further highlighted in this article.

  15. Extending Differential Fault Analysis to Dynamic S-Box Advanced Encryption Standard Implementations

    Science.gov (United States)

    2014-09-18

    EXTENDING DIFFERENTIAL FAULT ANALYSIS TO DYNAMIC S-BOX ADVANCED ENCRYPTION STANDARD IMPLEMENTATIONS THESIS Bradley M. Flamm, Civilian AFIT-ENG-T-14-S...Government and is not subject to copyright protection in the United States. AFIT-ENG-T-14-S-08 EXTENDING DIFFERENTIAL FAULT ANALYSIS TO DYNAMIC S-BOX...RELEASE; DISTRIBUTION UNLIMITED AFIT-ENG-T-14-S-08 EXTENDING DIFFERENTIAL FAULT ANALYSIS TO DYNAMIC S-BOX ADVANCED ENCRYPTION STANDARD IMPLEMENTATIONS

  16. Avogadro: an advanced semantic chemical editor, visualization, and analysis platform

    Directory of Open Access Journals (Sweden)

    Hanwell Marcus D

    2012-08-01

    Full Text Available Abstract Background The Avogadro project has developed an advanced molecule editor and visualizer designed for cross-platform use in computational chemistry, molecular modeling, bioinformatics, materials science, and related areas. It offers flexible, high quality rendering, and a powerful plugin architecture. Typical uses include building molecular structures, formatting input files, and analyzing output of a wide variety of computational chemistry packages. By using the CML file format as its native document type, Avogadro seeks to enhance the semantic accessibility of chemical data types. Results The work presented here details the Avogadro library, which is a framework providing a code library and application programming interface (API with three-dimensional visualization capabilities; and has direct applications to research and education in the fields of chemistry, physics, materials science, and biology. The Avogadro application provides a rich graphical interface using dynamically loaded plugins through the library itself. The application and library can each be extended by implementing a plugin module in C++ or Python to explore different visualization techniques, build/manipulate molecular structures, and interact with other programs. We describe some example extensions, one which uses a genetic algorithm to find stable crystal structures, and one which interfaces with the PackMol program to create packed, solvated structures for molecular dynamics simulations. The 1.0 release series of Avogadro is the main focus of the results discussed here. Conclusions Avogadro offers a semantic chemical builder and platform for visualization and analysis. For users, it offers an easy-to-use builder, integrated support for downloading from common databases such as PubChem and the Protein Data Bank, extracting chemical data from a wide variety of formats, including computational chemistry output, and native, semantic support for the CML file format

  17. Latest results from lattice N=4 supersymmetric Yang--Mills

    CERN Document Server

    Schaich, David; Damgaard, Poul H; Giedt, Joel

    2016-01-01

    We present some of the latest results from our numerical investigations of N=4 supersymmetric Yang--Mills theory formulated on a space-time lattice. Based on a construction that exactly preserves a single supersymmetry at non-zero lattice spacing, we recently developed an improved lattice action that is now being employed in large-scale calculations. Here we update our studies of the static potential using this new action, also applying tree-level lattice perturbation theory to improve the analysis of the potential itself. Considering relatively weak couplings, we obtain results for the Coulomb coefficient that are consistent with continuum perturbation theory.

  18. Advances in face detection and facial image analysis

    CERN Document Server

    Celebi, M; Smolka, Bogdan

    2016-01-01

    This book presents the state-of-the-art in face detection and analysis. It outlines new research directions, including in particular psychology-based facial dynamics recognition, aimed at various applications such as behavior analysis, deception detection, and diagnosis of various psychological disorders. Topics of interest include face and facial landmark detection, face recognition, facial expression and emotion analysis, facial dynamics analysis, face classification, identification, and clustering, and gaze direction and head pose estimation, as well as applications of face analysis.

  19. Thermoeconomic Analysis of Advanced Solar-Fossil Combined Power Plants

    OpenAIRE

    Yassine Allani; Klaus Ziegler; Daniel Favrat; Malick Kane

    2000-01-01

    Hybrid solar thermal power plants (with parabolic trough type of solar collectors) featuring gas burners and Rankine steam cycles have been successfully demonstrated by California's Solar Electric Generating System (SEGS). This system has been proven to be one of the most efficient and economical schemes to convert solar energy into electricity. Recent technological progress opens interesting prospects for advanced cycle concepts: a) the ISCCS (Integrated Solar Combined Cycle System)...

  20. Control Systems with Saturating Inputs Analysis Tools and Advanced Design

    CERN Document Server

    Corradini, Maria Letizia; Giannoni, Fabio; Orlando, Giuseppe

    2012-01-01

    This series aims to report new developments in the fields of control and information sciences - quickly, informally and at a high level. The type of material considered for publication includes: 1. Preliminary drafts of monographs and advanced textbooks 2. Lectures on a new field, or presenting a new angle on a classical field 3. Research reports 4. Reports of meetings, provided they are a) of exceptional interest and b) devoted to a specific topic. The timeliness of subject material is very important.

  1. Latest AMS Results on Cosmic Ray fluxes

    Science.gov (United States)

    Bertucci, Bruna; AMS Collaboration

    2017-01-01

    AMS-02 is a wide acceptance high-energy physics experiment installed on the International Space Station in May 2011 and it has been operating continuously since then. Accurate studies of CR composition and energy spectra can be performed in AMS thanks to the unprecedented collected statistics - more than 90 billion events as of today - and the redundant measurements of particle charge, velocity, rigidity and energy. In this contribution we will present an overview of the latest results on anti-particles, electrons and light nuclei fluxes. On behalf of the AMS Collaboration.

  2. Increase in flexibility with latest technologies

    Energy Technology Data Exchange (ETDEWEB)

    Fuebi, Michael; Krull, Florian Felix [RWE Technology GmbH, Essen (Germany); Ladwig, Michael [Alstom (Switzerland) AG, Baden (Switzerland)

    2012-07-01

    Flexibility demands on conventional power plants rise to ensure grid stability within a power generation mix with drastically increasing capacities of renewable power generation sources such as wind farms and photovoltaics. In this paper flexibility requirements for a power plant portfolio are discussed. Through selected examples of projects from RWE's current investment programme, comprising around 13 GW of efficient and flexible power plant capacity in Germany, the Netherlands, Turkey and the UK, application of the latest technologies to fulfil flexibility requirements is presented. Further, the potential of smart retrofits in terms of combined flexibility and efficiency gains is illustrated by means of an existing power plant unit retrofit project. (orig.)

  3. Latest ATLAS results from Run 2

    CERN Document Server

    Gemme, Claudia; The ATLAS collaboration

    2016-01-01

    After the fi rst LHC long shutdown with upgrades to the machine and the detectors, since 2015 the ATLAS experiment recorded more than 30 fb-1 of integrated luminosity of pp collision data at 13 TeV centre- of-mass energy. The data collected to date, the detector and physics per- formance, and measurements of Standard Model processes are reviewed briefly before summarising the latest ATLAS results in the Brout- Englert-Higgs sector, where substantial progress has been made since the discovery. Searches for physics phenomena beyond the Standard Model are also summarized. These proceedings reflect only a brief summary of the material presented at the conference.

  4. [Advances in energy analysis of agro-ecosystems].

    Science.gov (United States)

    Lu, Hongfang; Lan, Shengfang; Chen, Feipeng; Peng, Shaolin

    2004-01-01

    The energy analysis of agro-ecosystems from the view point of energy flow is a quantitative study on the function of agro-ecosystem, and is one of the most important aspects in agro-ecosystem study. In this paper, the history and some current progresses of energy analysis on agro-ecosystems were reviewed briefly, and the difference and breakthrough of emergy analysis theory with the traditional energy analysis method, some current challenges in front of emergy analysis of agro-ecosystems, and some of the new trends were discussed. Using the direct and indirect cost of solar energy to evaluate any energy or material, emergy analysis is the new development of energy analysis, not only in concept but also on calculation method. Developing to emergy analysis phase, there were still some deficiencies on energy analysis of agro-ecosystem, such as the complicate calculation of transformation and the vacancy of energy index for sustainable development, etc. How to solve these problems combined with the clearing of the maximum Em-power principle, the combination among energy analysis, emergy analysis, material analysis and landscape analysis has made up of the current and future trends of energy analysis of agro-ecosystem.

  5. Direct methods for limit and shakedown analysis of structures advanced computational algorithms and material modelling

    CERN Document Server

    Pisano, Aurora; Weichert, Dieter

    2015-01-01

    Articles in this book examine various materials and how to determine directly the limit state of a structure, in the sense of limit analysis and shakedown analysis. Apart from classical applications in mechanical and civil engineering contexts, the book reports on the emerging field of material design beyond the elastic limit, which has further industrial design and technological applications. Readers will discover that “Direct Methods” and the techniques presented here can in fact be used to numerically estimate the strength of structured materials such as composites or nano-materials, which represent fruitful fields of future applications.   Leading researchers outline the latest computational tools and optimization techniques and explore the possibility of obtaining information on the limit state of a structure whose post-elastic loading path and constitutive behavior are not well defined or well known. Readers will discover how Direct Methods allow rapid and direct access to requested information in...

  6. Analysis of advanced solar hybrid desiccant cooling systems for buildings

    Energy Technology Data Exchange (ETDEWEB)

    Schlepp, D.; Schultz, K.

    1984-10-01

    This report describes an assessment of the energy savings possible from developing hybrid desiccant/vapor-compression air conditioning systems. Recent advances in dehumidifier design for solar desiccant cooling systems have resulted in a dehumidifier with a low pressure drop and high efficiency in heat and mass transfer. A recent study on hybrid desiccant/vapor compression systems showed a 30%-80% savings in resource energy when compared with the best conventional systems with vapor compression. A system consisting of a dehumidifier with vapor compression subsystems in series was found to be the simplest and best overall performer.

  7. Multivariate data analysis as a tool in advanced quality monitoring in the food production chain

    DEFF Research Database (Denmark)

    Bro, R.; van den Berg, F.; Thybo, A.;

    2002-01-01

    This paper summarizes some recent advances in mathematical modeling of relevance in advanced quality monitoring in the food production chain. Using chemometrics-multivariate data analysis - it is illustrated how to tackle problems in food science more efficiently and, moreover, solve problems tha...... processing, and will cover areas such as analysis of variance, monitoring and handling of sampling variation, calibration, exploration/data mining and hard modeling. (C) 2002 Elsevier Science Ltd. All rights reserved.......This paper summarizes some recent advances in mathematical modeling of relevance in advanced quality monitoring in the food production chain. Using chemometrics-multivariate data analysis - it is illustrated how to tackle problems in food science more efficiently and, moreover, solve problems...... that could not otherwise be handled before. The different mathematical models are all exemplified by food related subjects to underline the generic use of the models within the food chain. Applications will be given from meat, storage, vegetable characterization, fish quality monitoring and industrial food...

  8. Design and analysis of advanced flight planning concepts

    Science.gov (United States)

    Sorensen, John A.

    1987-01-01

    The objectives of this continuing effort are to develop and evaluate new algorithms and advanced concepts for flight management and flight planning. This includes the minimization of fuel or direct operating costs, the integration of the airborne flight management and ground-based flight planning processes, and the enhancement of future traffic management systems design. Flight management (FMS) concepts are for on-board profile computation and steering of transport aircraft in the vertical plane between a city pair and along a given horizontal path. Flight planning (FPS) concepts are for the pre-flight ground based computation of the three-dimensional reference trajectory that connects the city pair and specifies the horizontal path, fuel load, and weather profiles for initializing the FMS. As part of these objectives, a new computer program called EFPLAN has been developed and utilized to study advanced flight planning concepts. EFPLAN represents an experimental version of an FPS. It has been developed to generate reference flight plans compatible as input to an FMS and to provide various options for flight planning research. This report describes EFPLAN and the associated research conducted in its development.

  9. Data analysis of asymmetric structures advanced approaches in computational statistics

    CERN Document Server

    Saito, Takayuki

    2004-01-01

    Data Analysis of Asymmetric Structures provides a comprehensive presentation of a variety of models and theories for the analysis of asymmetry and its applications and provides a wealth of new approaches in every section. It meets both the practical and theoretical needs of research professionals across a wide range of disciplines and  considers data analysis in fields such as psychology, sociology, social science, ecology, and marketing. In seven comprehensive chapters this guide details theories, methods, and models for the analysis of asymmetric structures in a variety of disciplines and presents future opportunities and challenges affecting research developments and business applications.

  10. Source mask optimization study based on latest Nikon immersion scanner

    Science.gov (United States)

    Zhu, Jun; Wei, Fang; Chen, Lijun; Zhang, Chenming; Zhang, Wei; Nishinaga, Hisashi; El-Sewefy, Omar; Gao, Gen-Sheng; Lafferty, Neal; Meiring, Jason; Zhang, Recoo; Zhu, Cynthia

    2016-03-01

    The 2x nm logic foundry node has many challenges since critical levels are pushed close to the limits of low k1 ArF water immersion lithography. For these levels, improvements in lithographic performance can translate to decreased rework and increased yield. Source Mask Optimization (SMO) is one such route to realize these image fidelity improvements. During SMO, critical layout constructs are intensively optimized in both the mask and source domain, resulting in a solution for maximum lithographic entitlement. From the hardware side, advances in source technology have enabled free-form illumination. The approach allows highly customized illumination, enabling the practical application of SMO sources. The customized illumination sources can be adjusted for maximum versatility. In this paper, we present a study on a critical layer of an advanced foundry logic node using the latest ILT based SMO software, paired with state-of-the-art scanner hardware and intelligent illuminator. Performance of the layer's existing POR source is compared with the ideal SMO result and the installed source as realized on the intelligent illuminator of an NSR-S630D scanner. Both simulation and on-silicon measurements are used to confirm that the performance of the studied layer meets established specifications.

  11. Advanced energy analysis of high temperature fuel cell systems

    NARCIS (Netherlands)

    De Groot, A.

    2004-01-01

    In this thesis the performance of high temperature fuel cell systems is studied using a new method of exergy analysis. The thesis consists of three parts: ⢠In the first part a new analysis method is developed, which not only considers the total exergy losses in a unit operation, but which distingu

  12. Advanced Polymer Composite Molding Through Intelligent Process Analysis and Control

    Science.gov (United States)

    2004-11-30

    In this project. process analysis of Resin Transfer Molding (RTM) was carried out and adaptive process control models were developed. In addition, a...aforementioned work in three separate sections: (1) process analysis and adaptive control modeling, (2) manufacturing of non-invasive sensor, end (3) list of publications resulting from this project.

  13. Recent advances on thermal analysis of stretchable electronics

    Directory of Open Access Journals (Sweden)

    Yuhang Li

    2016-01-01

    Full Text Available Stretchable electronics, which offers the performance of conventional wafer-based devices and mechanical properties of a rubber band, enables many novel applications that are not possible through conventional electronics due to its brittle nature. One effective strategy to realize stretchable electronics is to design the inorganic semiconductor material in a stretchable format on a compliant elastomeric substrate. Engineering thermal management is essential for the development of stretchable electronics to avoid adverse thermal effects on its performance as well as in applications involving human body and biological tissues where even 1–2 °C temperature increase is not allowed. This article reviews the recent advances in thermal management of stretchable inorganic electronics with focuses on the thermal models and their comparisons to experiments and finite element simulations.

  14. Advances in analysis and control of timedelayed dynamical systems

    CERN Document Server

    Sun, Jianqiao

    2013-01-01

    Analysis and control of timedelayed systems have been applied in a wide range of applications, ranging from mechanical, control, economic, to biological systems. Over the years, there has been a steady stream of interest in timedelayed dynamic systems, this book takes a snap shot of recent research from the world leading experts in analysis and control of dynamic systems with time delay to provide a bird's eye view of its development. The topics covered in this book include solution methods, stability analysis and control of periodic dynamic systems with time delay, bifurcations, stochastic dy

  15. Single-cell analysis: Advances and future perspectives

    Directory of Open Access Journals (Sweden)

    Emir Hodzic

    2016-11-01

    Full Text Available The last several years have seen rapid development of technologies and methods that permit a detailed analysis of the genome and transcriptome of a single cell. Recent evidence from studies of single cells reveals that each cell type has a distinct lineage and function. The lineage and stage of development of each cell determine how they respond to each other and the environment. Experimental approaches that utilize single-cell analysis are effective means to understand how cell networks work in concert to coordinate a response at the population level; recent progress in single-cell analysis is offering a glimpse at the future.

  16. Latest results from the Pierre Auger Observatory

    Science.gov (United States)

    Dembinski, Hans P.; Pierre Auger Collaboration

    2012-02-01

    The Pierre Auger Observatory, located in the Province of Mendoza, Argentina, is the World's largest detector for cosmic rays at ultra-high energies. In its seven years of operation it has collected an exposure of more than 20000 km2 sr yr, larger than all previous experiments combined. Its original design, optimized for the energy range 1018 eV to 1020 eV, is currently enhanced to cover energies down to almost 1017 eV. We give an overview of the latest results with a focus on the prospect to study nuclear interactions with cosmic rays and conclude with a brief outlook on developments and extensions of the observatory. Full author list

  17. The GIS and data solution for advanced business analysis

    OpenAIRE

    Carmen RADUT

    2009-01-01

    The GIS Business Analyst is a suite of Geographic Information System (GIS)-enabled tools, wizards, and data that provides business professionals with a complete solution for site evaluation, selective customer profiling, and trade area market analysis. Running simple reports, mapping the results, and performing complex probability models are among the capabilities The GIS Business Analyst offers in one affordable desktop analysis solution. Data and analyses produced by The GIS Business Analys...

  18. Recent advances in the application of high performance liquid chromatography in the analysis of polyphenols in wine and propolis.

    Science.gov (United States)

    Medić-Sarić, Marica; Rastija, Vesna; Bojić, Mirza

    2011-01-01

    Wine and propolis are among the richest sources of polyphenolics. Flavonoids and phenolic acids are main pharmacological components whose benefits have been shown in numerous reports. This paper presents a review of the latest applications of HPLC for determination of polyphenolics in propolis and wine. Special attention is focused on sample preparation, chromatographic conditions, and detection of polyphenolics. HPLC will undoubtedly be the most used method that is readily available for analysis, as well as for isolation of polyphenolics in complex mixtures.

  19. Stress analysis for the candidate of lower end fitting of advanced LWR fuel using FEM

    Energy Technology Data Exchange (ETDEWEB)

    Lee, S. S.; Moon, Y. C. [Korea University of Technology and Education, Chonan (Korea, Republic of); Kim, H. K. [Korea Nuclear Fuel Company, Taejon (Korea, Republic of)

    2002-10-01

    The geometric modeling has been conducted for the candidate of advanced LWR fuel using the three-dimensional solid modeler. Then the three-dimensional stress analysis using MSC/NASTRAN has been performed. The evaluation for the mechanical integrity of the candidate has been performed based on the stress distribution obtained from the finite elements analysis.

  20. Monte Carlo simulations to advance characterisation of landmines by pulsed fast/thermal neutron analysis

    NARCIS (Netherlands)

    Maucec, M.; Rigollet, C.

    2004-01-01

    The performance of a detection system based on the pulsed fast/thermal neutron analysis technique was assessed using Monte Carlo simulations. The aim was to develop and implement simulation methods, to support and advance the data analysis techniques of the characteristic gamma-ray spectra, potentia

  1. How does uncertainty shape patient experience in advanced illness? A secondary analysis of qualitative data

    OpenAIRE

    Etkind, Simon Noah; Bristowe, Katherine Rachel; Bailey, Katharine; Selman, Lucy Ellen; Murtagh, Felicity Fliss

    2016-01-01

    BACKGROUND: Uncertainty is common in advanced illness but is infrequently studied in this context. If poorly addressed, uncertainty can lead to adverse patient outcomes.AIM: We aimed to understand patient experiences of uncertainty in advanced illness and develop a typology of patients' responses and preferences to inform practice.DESIGN: Secondary analysis of qualitative interview transcripts. Studies were assessed for inclusion and interviews were sampled using maximum-variation sampling. A...

  2. Neoadjuvant chemotherapy for advanced gastric cancer:A meta-analysis

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    AIM:To study the value of neoadjuvant chemotherapy (NAC) for advanced gastric cancer by performing a meta-analysis of the published studies.METHODS:All published controlled trials of NAC for advanced gastric cancer vs no therapy before surgery were searched.Studies that included patients with metastases at enrollment were excluded.Databases included Cochrane Library of Clinical Comparative Trials,MEDLINE,Embase,and American Society of Clinical Oncology meeting abstracts from 1978 to 2010.The censor date was...

  3. Research advance in safety analysis methods for high concrete dam

    Institute of Scientific and Technical Information of China (English)

    REN; QingWen; XU; LanYu; WAN; YunHui

    2007-01-01

    High tensile stresses occurred in high concrete dams and in their foundation lead to the growing importance of their safety with the increase of concrete dam height.Without any exiting specification or successful experiences of concrete dams up to 300 m at home and abroad for reference,experts feel obliged to figure out how to perform safety analysis on high concrete dam.This paper involves the main contents and mechanical features of the safety analysis on high concrete dam and shows the current state and progress of the analysis methods.For the insufficiency and problems existing in normative methods,study on modern numerical method such as finite element method must be strengthened to find out the stress control criterion which is in accordance with the methods.Two aspects of the safety analysis of high dam--local damage from material level and integral destruction from structure level--should be considered.For the local damage,we should consider the non-homogeneity of material and strengthen the research of meso-damage mechanics.While for integral destruction of the system of high dam and its foundation,a study on non-strength theory should receive enough concerns.Further,attention should be paid to the research on the failure modes and criterions of high concrete dam failure analysis and safety evaluation,and the effect of uncertainty and classification of safety should be considered too.

  4. Advances in diagnosis and spatial analysis of cysticercosis and taeniasis.

    Science.gov (United States)

    Raoul, Francis; Li, Tiaoying; Sako, Yasuhito; Chen, Xingwang; Long, Changping; Yanagida, Tetsuya; Wu, Yunfei; Nakao, Minoru; Okamoto, Munehiro; Craig, Philip S; Giraudoux, Patrick; Ito, Akira

    2013-11-01

    Human cysticercosis, caused by accidental ingestion of eggs of Taenia solium, is one of the most pathogenic helminthiases and is listed among the 17 WHO Neglected Tropical Diseases. Controlling the life-cycle of T. solium between humans and pigs is essential for eradication of cysticercosis. One difficulty for the accurate detection and identification of T. solium species is the possible co-existence of two other human Taenia tapeworms (T. saginata and T. asiatica, which do not cause cysticercosis in humans). Several key issues for taeniasis/cysticercosis (T/C) evidence-based epidemiology and control are reviewed: (1) advances in immunological and molecular tools for screening of human and animals hosts and identification of Taenia species, with a focus on real-time detection of taeniasis carriers and infected animals in field community screenings, and (2) spatial ecological approaches that have been used to detect geospatial patterns of case distributions and to monitor pig activity and behaviour. Most recent eco-epidemiological studies undertaken in Sichuan province, China, are introduced and reviewed.

  5. Advances in the analysis of pressure interference tests

    Energy Technology Data Exchange (ETDEWEB)

    Martinez R, N. [Petroleos Mexicanos, PEMEX, Mexico City (Mexico); Samaniego V, F. [Univ. Nacional Autonoma de Mexico (Mexico)

    2010-12-15

    This paper presented an extension for radial, linear, and spherical flow conditions of the El-Khatib method for analyzing pressure interference tests through utilization of the pressure derivative. Conventional analysis of interference tests considers only radial flow, but some reservoirs have physical field conditions in which linear or spherical flow conditions prevail. The INTERFERAN system, a friendly computer code for the automatic analysis of pressure interference tests, was also discussed and demonstrated by way of 2 field cases. INTERFERAN relies on the principle of superposition in time and space to interpret a test of several wells with variable histories of production or injection or both. The first field case addressed interference tests conducted in the naturally fractured geothermal field of Klamath Falls, and the second field case was conducted in a river-formed bed in which linear flow conditions are dominant. The analysis was deemed to be reliable. 13 refs., 1 tab., 7 figs.

  6. Promising method advancement in palynology: a supplement to pollen analysis

    DEFF Research Database (Denmark)

    Enevold, Renée; Odgaard, Bent Vad

    2016-01-01

    The analysis of Non Pollen Palynomorphs (NPPs) has evolved over the last few decades to be a fruitful supplement to palynological surveys and has especially proven to be a useful addition when interpreting anthropogenic disturbance of the natural environment. NPPs in anthropogenic soils and archa......The analysis of Non Pollen Palynomorphs (NPPs) has evolved over the last few decades to be a fruitful supplement to palynological surveys and has especially proven to be a useful addition when interpreting anthropogenic disturbance of the natural environment. NPPs in anthropogenic soils...... from sediment-, pollen- and macrofossil analyses. Fungal ascospore x1000. Photo: Renée Enevold...

  7. Advanced Online Survival Analysis Tool for Predictive Modelling in Clinical Data Science.

    Science.gov (United States)

    Montes-Torres, Julio; Subirats, José Luis; Ribelles, Nuria; Urda, Daniel; Franco, Leonardo; Alba, Emilio; Jerez, José Manuel

    2016-01-01

    One of the prevailing applications of machine learning is the use of predictive modelling in clinical survival analysis. In this work, we present our view of the current situation of computer tools for survival analysis, stressing the need of transferring the latest results in the field of machine learning to biomedical researchers. We propose a web based software for survival analysis called OSA (Online Survival Analysis), which has been developed as an open access and user friendly option to obtain discrete time, predictive survival models at individual level using machine learning techniques, and to perform standard survival analysis. OSA employs an Artificial Neural Network (ANN) based method to produce the predictive survival models. Additionally, the software can easily generate survival and hazard curves with multiple options to personalise the plots, obtain contingency tables from the uploaded data to perform different tests, and fit a Cox regression model from a number of predictor variables. In the Materials and Methods section, we depict the general architecture of the application and introduce the mathematical background of each of the implemented methods. The study concludes with examples of use showing the results obtained with public datasets.

  8. The GIS and data solution for advanced business analysis

    Directory of Open Access Journals (Sweden)

    Carmen RADUT

    2009-12-01

    Full Text Available The GIS Business Analyst is a suite of Geographic Information System (GIS-enabled tools, wizards, and data that provides business professionals with a complete solution for site evaluation, selective customer profiling, and trade area market analysis. Running simple reports, mapping the results, and performing complex probability models are among the capabilities The GIS Business Analyst offers in one affordable desktop analysis solution. Data and analyses produced by The GIS Business Analyst can be shared across departments, reducing redundant research and marketing efforts, speeding analysis of results, and increasing employee efficiency. The GIS Business Analyst is the first suite of tools for unlocking the intelligence of geography, demographic, consumer lifestyle, and business data. It is a valuable asset for business decision making such as analyzing market share and competition, determining new site expansions or reductions, and targeting new customers. The ability to analyze and visualize the geographic component of business data reveals trends, patterns, and opportunities hidden in tabular data. By combining information, such as sales data of the organization, customer information, and competitor locations, with geographic data, such as demographics, territories, or store locations, the GIS Business Analyst helps the user better understand organization market, organization customers, and organization competition. The business intelligence systems bring geographic information systems, marketing analysis tools, and demographic data products together to offer the user powerful ways to compete in today's business strategies.

  9. Connecting Performance Analysis and Visualization to Advance Extreme Scale Computing

    Energy Technology Data Exchange (ETDEWEB)

    Bremer, Peer-Timo [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Mohr, Bernd [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Schulz, Martin [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Pasccci, Valerio [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Gamblin, Todd [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Brunst, Holger [Dresden Univ. of Technology (Germany)

    2015-07-29

    The characterization, modeling, analysis, and tuning of software performance has been a central topic in High Performance Computing (HPC) since its early beginnings. The overall goal is to make HPC software run faster on particular hardware, either through better scheduling, on-node resource utilization, or more efficient distributed communication.

  10. Progress in Conceptual Design and Analysis of Advanced Rotorcraft

    Science.gov (United States)

    Yamauchi, Gloria K.

    2012-01-01

    This presentation will give information on Multi-Disciplinary Analysis and Technology Development, including it's objectives and how they will be met. In addition, it will also present recent highlights including the Lift-Offset Civil Design and it's study conclusions, as well as, the LCTR2 Propulsion Concept's study conclusions. Recent publications and future publications will also be discussed.

  11. Computing support for advanced medical data analysis and imaging

    CERN Document Server

    Wiślicki, W; Białas, P; Czerwiński, E; Kapłon, Ł; Kochanowski, A; Korcyl, G; Kowal, J; Kowalski, P; Kozik, T; Krzemień, W; Molenda, M; Moskal, P; Niedźwiecki, S; Pałka, M; Pawlik, M; Raczyński, L; Rudy, Z; Salabura, P; Sharma, N G; Silarski, M; Słomski, A; Smyrski, J; Strzelecki, A; Wieczorek, A; Zieliński, M; Zoń, N

    2014-01-01

    We discuss computing issues for data analysis and image reconstruction of PET-TOF medical scanner or other medical scanning devices producing large volumes of data. Service architecture based on the grid and cloud concepts for distributed processing is proposed and critically discussed.

  12. Advancing School-Based Interventions through Economic Analysis

    Science.gov (United States)

    Olsson, Tina M.; Ferrer-Wreder, Laura; Eninger, Lilianne

    2014-01-01

    Commentators interested in school-based prevention programs point to the importance of economic issues for the future of prevention efforts. Many of the processes and aims of prevention science are dependent upon prevention resources. Although economic analysis is an essential tool for assessing resource use, the attention given economic analysis…

  13. Recent Advances in Risk Analysis and Management (RAM

    Directory of Open Access Journals (Sweden)

    Arpita Banerjee

    2014-12-01

    Full Text Available In today‟s age, organizations consider software development process as an investment activity which is dependent on the comprehensive and precise working of each phase in Software Development Lifecycle. Flaws from each phase could remain undetected starting from requirement phase till maintenance phase. The flaw or defects if left unattended in the respective phase will be carried forward to next phase aggregating the issues. These undetected flaws should be identified and removed as early as possible so as to reduce additional overheads. From the data available, it is concluded that risk analysis is a major factor which is ignored during all the phases of software development process resulting in the emergence of undetected defects and flaws. Because of the failure of many projects, the importance of risk analysis during software development process is now being well recognized. A series of reversed as well as assorted researches are proceeding towards analyzing the risk „right from the beginning‟ during the software development process. Through researchers have contributed significantly in the field, still more needs to be achieved. This paper presents a review of the current research being done in Risk Analysis and Management (RAM, based on the recently published work. The study is carried out with respect to analysis and management of risk in various phase of SDLC. Such a thorough review enables one to identify mature areas of research, as well as areas that need further investigation. Finally, after critical analysis of the current research findings, the future research directions are highlighted with their significance.

  14. RECENT ADVANCES IN RISK ANALYSIS AND MANAGEMENT (RAM

    Directory of Open Access Journals (Sweden)

    Arpita Banerjee

    2015-10-01

    Full Text Available In today‟s age, organizations consider software development process as an investment activity which is dependent on the comprehensive and precise working of each phase in Software Development Lifecycle. Flaws from each phase could remain undetected starting from requirement phase till maintenance phase. The flaw or defects if left unattended in the respective phase will be carried forward to next phase aggregating the issues. These undetected flaws should be identified and removed as early as possible so as to reduce additional overheads. From the data available, it is concluded that risk analysis is a major factor which is ignored during all the phases of software development process resulting in the emergence of undetected defects and flaws. Because of the failure of many projects, the importance of risk analysis during software development process is now being well recognized. A series of reversed as well as assorted researches are proceeding towards analyzing the risk „right from the beginning‟ during the software development process. Through researchers have contributed significantly in the field, still more needs to be achieved. This paper presents a review of the current research being done in Risk Analysis and Management (RAM, based on the recently published work. The study is carried out with respect to analysis and management of risk in various phase of SDLC. Such a thorough review enables one to identify mature areas of research, as well as areas that need further investigation. Finally, after critical analysis of the current research findings, the future research directions are highlighted with their significance.

  15. Recent advances in amino acid analysis by capillary electrophoresis.

    Science.gov (United States)

    Poinsot, Véréna; Carpéné, Marie-Anne; Bouajila, Jalloul; Gavard, Pierre; Feurer, Bernard; Couderc, François

    2012-01-01

    This paper describes the most important articles that have been published on amino acid analysis using CE during the period from June 2009 to May 2011 and follows the format of the previous articles of Smith (Electrophoresis 1999, 20, 3078-3083), Prata et al. (Electrophoresis 2001, 22, 4129-4138) and Poinsot et al. (Electrophoresis 2003, 24, 4047-4062; Electrophoresis 2006, 27, 176-194; Electrophoresis 2008, 29, 207-223; Electrophoresis 2010, 31, 105-121). We present new developments in amino acid analysis with CE, which are reported describing the use of lasers or light emitting diodes for fluorescence detection, conductimetry electrochemiluminescence detectors, mass spectrometry applications, and lab-on-a-chip applications using CE. In addition, we describe articles concerning clinical studies and neurochemical applications of these techniques.

  16. An advanced precision analysis of the SM vacuum stability

    CERN Document Server

    Bednyakov, A V

    2016-01-01

    The talk is devoted to the problem of stability of the Standard Model vacuum. The effective potential for the Higgs field, which can potentialy exhibit additional, deeper minimum, is considered as a convenient tool for addressing the problem. Different methods and approximations used to calculate the potential are considered. Special attention is paid to the renomalization-group approach that allows one to carry out three-loop analysis of the problem. By means of an explicit gauge-independent procedure the absolute stability bounds on the observed Higgs and top-quark masses are derived. The importance of high-order corrections is demonstrated. In addition, potential metastablity of the SM is discussed together with modifications of the analysis due to some New Physics.

  17. Characterization of PTFE Using Advanced Thermal Analysis Techniques

    Science.gov (United States)

    Blumm, J.; Lindemann, A.; Meyer, M.; Strasser, C.

    2010-10-01

    Polytetrafluoroethylene (PTFE) is a synthetic fluoropolymer used in numerous industrial applications. It is often referred to by its trademark name, Teflon. Thermal characterization of a PTFE material was carried out using various thermal analysis and thermophysical properties test techniques. The transformation energetics and specific heat were measured employing differential scanning calorimetry. The thermal expansion and the density changes were determined employing pushrod dilatometry. The viscoelastic properties (storage and loss modulus) were analyzed using dynamic mechanical analysis. The thermal diffusivity was measured using the laser flash technique. Combining thermal diffusivity data with specific heat and density allows calculation of the thermal conductivity of the polymer. Measurements were carried out from - 125 °C up to 150 °C. Additionally, measurements of the mechanical properties were carried out down to - 170 °C. The specific heat tests were conducted into the fully molten regions up to 370 °C.

  18. Towards Advanced Data Analysis by Combining Soft Computing and Statistics

    CERN Document Server

    Gil, María; Sousa, João; Verleysen, Michel

    2013-01-01

    Soft computing, as an engineering science, and statistics, as a classical branch of mathematics, emphasize different aspects of data analysis. Soft computing focuses on obtaining working solutions quickly, accepting approximations and unconventional approaches. Its strength lies in its flexibility to create models that suit the needs arising in applications. In addition, it emphasizes the need for intuitive and interpretable models, which are tolerant to imprecision and uncertainty. Statistics is more rigorous and focuses on establishing objective conclusions based on experimental data by analyzing the possible situations and their (relative) likelihood. It emphasizes the need for mathematical methods and tools to assess solutions and guarantee performance. Combining the two fields enhances the robustness and generalizability of data analysis methods, while preserving the flexibility to solve real-world problems efficiently and intuitively.

  19. Advanced phytochemical analysis of herbal tea in China.

    Science.gov (United States)

    Zhao, J; Deng, J W; Chen, Y W; Li, S P

    2013-10-25

    Herbal tea is a commonly consumed beverage brewed from the leaves, flowers, seeds, fruits, stems and roots of plants species rather than Camellia sinensis L., which has been widely used for health care and diseases prevention for centuries. With the increasing consumption of herbal tea, a number of public health issues e.g., efficacy, safety and quality assurance have attracted concern. However, to date, there is no a review focus on herbal tea. Phytochemical analysis, as a key step to investigate the chemical composition of herbal tea and ensure the quality, is very important. In this review, we summarized and discussed the recent development (2005-2012) in phytochemical analysis of herbal tea commonly used in China.

  20. Nonstandard Analysis Applied to Advanced Undergraduate Mathematics - Infinitesimal Modeling

    OpenAIRE

    Herrmann, Robert A.

    2003-01-01

    This is a Research and Instructional Development Project from the U. S. Naval Academy. In this monograph, the basic methods of nonstandard analysis for n-dimensional Euclidean spaces are presented. Specific rules are deveoped and these methods and rules are applied to rigorous integral and differential modeling. The topics include Robinson infinitesimals, limited and infinite numbers; convergence theory, continuity, *-transfer, internal definition, hyprefinite summation, Riemann-Stieltjes int...

  1. Advanced uncertainty modelling for container port risk analysis.

    Science.gov (United States)

    Alyami, Hani; Yang, Zaili; Riahi, Ramin; Bonsall, Stephen; Wang, Jin

    2016-08-13

    Globalization has led to a rapid increase of container movements in seaports. Risks in seaports need to be appropriately addressed to ensure economic wealth, operational efficiency, and personnel safety. As a result, the safety performance of a Container Terminal Operational System (CTOS) plays a growing role in improving the efficiency of international trade. This paper proposes a novel method to facilitate the application of Failure Mode and Effects Analysis (FMEA) in assessing the safety performance of CTOS. The new approach is developed through incorporating a Fuzzy Rule-Based Bayesian Network (FRBN) with Evidential Reasoning (ER) in a complementary manner. The former provides a realistic and flexible method to describe input failure information for risk estimates of individual hazardous events (HEs) at the bottom level of a risk analysis hierarchy. The latter is used to aggregate HEs safety estimates collectively, allowing dynamic risk-based decision support in CTOS from a systematic perspective. The novel feature of the proposed method, compared to those in traditional port risk analysis lies in a dynamic model capable of dealing with continually changing operational conditions in ports. More importantly, a new sensitivity analysis method is developed and carried out to rank the HEs by taking into account their specific risk estimations (locally) and their Risk Influence (RI) to a port's safety system (globally). Due to its generality, the new approach can be tailored for a wide range of applications in different safety and reliability engineering and management systems, particularly when real time risk ranking is required to measure, predict, and improve the associated system safety performance.

  2. DATA ANALYSIS TECHNIQUES IN SERVICE QUALITY LITERATURE: ESSENTIALS AND ADVANCES

    Directory of Open Access Journals (Sweden)

    Mohammed naved Khan

    2013-05-01

    Full Text Available Academic and business researchers have for long debated on the most appropriate data analysis techniques that can be employed in conducting empirical researches in the domain of services marketing. On the basis of an exhaustive review of literature, the present paper attempts to provide a concise and schematic portrayal of generally followed data analysis techniques in the field of services quality literature. Collectively, the extant literature suggests that there is a growing trend among researchers to rely on higher order multivariate techniques viz. confirmatory factor analysis, structural equation modeling etc. to generate and analyze complex models, while at times ignoring very basic and yet powerful procedures such as mean, t-Test, ANOVA and correlation. The marked shift in orientation of researchers towards using sophisticated analytical techniques can largely beattributed to the competition within the community of researchers in social sciences in general and those working in the area of service quality in particular as also growing demands of reviewers ofjournals. From a pragmatic viewpoint, it is expected that the paper will serve as a useful source of information and provide deeper insights to academic researchers, consultants, and practitionersinterested in modelling patterns of service quality and arriving at optimal solutions to increasingly complex management problems.

  3. Advanced analysis and event reconstruction for the CTA Observatory

    CERN Document Server

    Becherini, Y; Pita, S; Punch, M

    2012-01-01

    The planned Cherenkov Telescope Array (CTA) is a future observatory for very-high-energy (VHE) gamma-ray astronomy composed of one site per hemisphere. It aims at 10 times better sensitivity, a better angular resolution and wider energy coverage than current installations such as H.E.S.S., MAGIC and VERITAS. In order to achieve this level of performance, both the design of the telescopes and the analysis algorithms are being studied and optimized within the CTA Monte-Carlo working group. Here, we present ongoing work on the data analysis for both the event reconstruction (energy, direction) and gamma/hadron separation, carried out within the HAP (H.E.S.S. Analysis Package) software framework of the H.E.S.S. collaboration, for this initial study. The event reconstruction uses both Hillas-parameter-based algorithms and an improved version of the 3D-Model algorithm. For the gamma/hadron discrimination, original and robust discriminant variables are used and treated with Boosted Decision Trees (BDTs) in the TMVA ...

  4. Deterministic and risk-informed approaches for safety analysis of advanced reactors: Part I, deterministic approaches

    Energy Technology Data Exchange (ETDEWEB)

    Ahn, Sang Kyu [Korea Institute of Nuclear Safety, 19 Kusong-dong, Yuseong-gu, Daejeon 305-338 (Korea, Republic of); Kim, Inn Seock, E-mail: innseockkim@gmail.co [ISSA Technology, 21318 Seneca Crossing Drive, Germantown, MD 20876 (United States); Oh, Kyu Myung [Korea Institute of Nuclear Safety, 19 Kusong-dong, Yuseong-gu, Daejeon 305-338 (Korea, Republic of)

    2010-05-15

    The objective of this paper and a companion paper in this issue (part II, risk-informed approaches) is to derive technical insights from a critical review of deterministic and risk-informed safety analysis approaches that have been applied to develop licensing requirements for water-cooled reactors, or proposed for safety verification of the advanced reactor design. To this end, a review was made of a number of safety analysis approaches including those specified in regulatory guides and industry standards, as well as novel methodologies proposed for licensing of advanced reactors. This paper and the companion paper present the review insights on the deterministic and risk-informed safety analysis approaches, respectively. These insights could be used in making a safety case or developing a new licensing review infrastructure for advanced reactors including Generation IV reactors.

  5. Proceedings: Workshop on advanced mathematics and computer science for power systems analysis

    Energy Technology Data Exchange (ETDEWEB)

    Esselman, W.H.; Iveson, R.H. (Electric Power Research Inst., Palo Alto, CA (United States))

    1991-08-01

    The Mathematics and Computer Workshop on Power System Analysis was held February 21--22, 1989, in Palo Alto, California. The workshop was the first in a series sponsored by EPRI's Office of Exploratory Research as part of its effort to develop ways in which recent advances in mathematics and computer science can be applied to the problems of the electric utility industry. The purpose of this workshop was to identify research objectives in the field of advanced computational algorithms needed for the application of advanced parallel processing architecture to problems of power system control and operation. Approximately 35 participants heard six presentations on power flow problems, transient stability, power system control, electromagnetic transients, user-machine interfaces, and database management. In the discussions that followed, participants identified five areas warranting further investigation: system load flow analysis, transient power and voltage analysis, structural instability and bifurcation, control systems design, and proximity to instability. 63 refs.

  6. Suppliers Showcase Their Latest Eco Collections%Suppliers Showcase Their Latest Eco Collections

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Planet Textiles debut - conference on sustainability with internationally renowned speakers confirmed As demanct for sustainably produced fashion increases worldwide, designers and buyers attending Intertextile Shanghai Apparel Fabrics can expect to find a number of suppliers showcasing their latest eco fabric collections. In addition to a growing number of eco suppliers participating at the fair, which takes place from 18 - 21 October 2011, there will be special trend forums, designer fabrics and zones for:

  7. A Survey of Advances in Vision-Based Human Motion Capture and Analysis

    DEFF Research Database (Denmark)

    Moeslund, Thomas B.; Hilton, Adrian; Krüger, Volker

    2006-01-01

    This survey reviews advances in human motion capture and analysis from 2000 to 2006, following a previous survey of papers up to 2000 Human motion capture continues to be an increasingly active research area in computer vision with over 350 publications over this period. A number of significant r...... actions and behavior. This survey reviews recent trends in video based human capture and analysis, as well as discussing open problems for future research to achieve automatic visual analysis of human movement....

  8. Stress analysis of advanced attack helicopter composite main rotor blade root end lug

    Science.gov (United States)

    Baker, D. J.

    1982-01-01

    Stress analysis of the Advanced Attack Helicopter (AAH) composite main rotor blade root end lug is described. The stress concentration factor determined from a finite element analysis is compared to an empirical value used in the lug design. The analysis and test data indicate that the stress concentration is primarily a function of configuration and independent of the range of material properties typical of Kevlar-49/epoxy and glass epoxy.

  9. Advances in analysis the legacy of Elias M. Stein

    CERN Document Server

    Fefferman, Charles; Phong, DH; Wainger, Stephen

    2014-01-01

    Princeton University's Elias Stein was the first mathematician to see the profound interconnections that tie classical Fourier analysis to several complex variables and representation theory. His fundamental contributions include the Kunze-Stein phenomenon, the construction of new representations, the Stein interpolation theorem, the idea of a restriction theorem for the Fourier transform, and the theory of Hp Spaces in several variables. Through his great discoveries, through books that have set the highest standard for mathematical exposition, and through his influence on his many collabora

  10. Cost analysis of advanced turbine blade manufacturing processes

    Science.gov (United States)

    Barth, C. F.; Blake, D. E.; Stelson, T. S.

    1977-01-01

    A rigorous analysis was conducted to estimate relative manufacturing costs for high technology gas turbine blades prepared by three candidate materials process systems. The manufacturing costs for the same turbine blade configuration of directionally solidified eutectic alloy, an oxide dispersion strengthened superalloy, and a fiber reinforced superalloy were compared on a relative basis to the costs of the same blade currently in production utilizing the directional solidification process. An analytical process cost model was developed to quantitatively perform the cost comparisons. The impact of individual process yield factors on costs was also assessed as well as effects of process parameters, raw materials, labor rates and consumable items.

  11. Advances in the analysis and prediction of turbulent viscoelastic flows

    Science.gov (United States)

    Gatski, T. B.; Thais, L.; Mompean, G.

    2014-08-01

    It has been well-known for over six decades that the addition of minute amounts of long polymer chains to organic solvents, or water, can lead to significant turbulent drag reduction. This discovery has had many practical applications such as in pipeline fluid transport, oil well operations, vehicle design and submersible vehicle projectiles, and more recently arteriosclerosis treatment. However, it has only been the last twenty-five years that the full utilization of direct numerical simulation of such turbulent viscoelastic flows has been achieved. The unique characteristics of viscoelastic fluid flow are dictated by the nonlinear differential relationship between the flow strain rate field and the extra-stress induced by the additive polymer. A primary motivation for the analysis of these turbulent fluid flows is the understanding of the effect on the dynamic transfer of energy in the turbulent flow due to the presence of the extra-stress field induced by the presence of the viscoelastic polymer chain. Such analyses now utilize direct numerical simulation data of fully developed channel flow for the FENE-P (Finite Extendable Nonlinear Elastic - Peterlin) fluid model. Such multi-scale dynamics suggests an analysis of the transfer of energy between the various component motions that include the turbulent kinetic energy, and the mean polymeric and elastic potential energies. It is shown that the primary effect of the interaction between the turbulent and polymeric fields is to transfer energy from the turbulence to the polymer.

  12. Advances in computational design and analysis of airbreathing propulsion systems

    Science.gov (United States)

    Klineberg, John M.

    1989-01-01

    The development of commercial and military aircraft depends, to a large extent, on engine manufacturers being able to achieve significant increases in propulsion capability through improved component aerodynamics, materials, and structures. The recent history of propulsion has been marked by efforts to develop computational techniques that can speed up the propulsion design process and produce superior designs. The availability of powerful supercomputers, such as the NASA Numerical Aerodynamic Simulator, and the potential for even higher performance offered by parallel computer architectures, have opened the door to the use of multi-dimensional simulations to study complex physical phenomena in propulsion systems that have previously defied analysis or experimental observation. An overview of several NASA Lewis research efforts is provided that are contributing toward the long-range goal of a numerical test-cell for the integrated, multidisciplinary design, analysis, and optimization of propulsion systems. Specific examples in Internal Computational Fluid Mechanics, Computational Structural Mechanics, Computational Materials Science, and High Performance Computing are cited and described in terms of current capabilities, technical challenges, and future research directions.

  13. Latest generation of halogen-containing pesticides.

    Science.gov (United States)

    Jeschke, Peter

    2017-02-01

    Agriculture is confronted with enormous challenges, from production of enough high-quality food to water use, environmental impacts and issues combined with a continually growing world population. Modern agricultural chemistry has to support farmers by providing innovative agrichemicals, used in applied agriculture. In this context, the introduction of halogen atoms into an active ingredient is still an important tool to modulate the properties of new crop protection compounds. Since 2010, around 96% of the launched products (herbicides, fungicides, insecticides/acaricides and nematicides) contain halogen atoms. The launched nematicides contain the largest number of halogen atoms, followed by insecticides/acaricides, herbicides and fungicides. In this context, fungicides and herbicides contain in most cases fluorine atoms, whereas nematicides and insecticides contain in most cases 'mixed' halogen atoms, for example chlorine and fluorine. This review gives an overview of the latest generation of halogen-containing pesticides launched over the past 6 years and describes current halogen-containing development candidates. © 2017 Society of Chemical Industry.

  14. Analysis of Sequence Diagram Layout in Advanced UML Modelling Tools

    Directory of Open Access Journals (Sweden)

    Ņikiforova Oksana

    2016-05-01

    Full Text Available System modelling using Unified Modelling Language (UML is the task that should be solved for software development. The more complex software becomes the higher requirements are stated to demonstrate the system to be developed, especially in its dynamic aspect, which in UML is offered by a sequence diagram. To solve this task, the main attention is devoted to the graphical presentation of the system, where diagram layout plays the central role in information perception. The UML sequence diagram due to its specific structure is selected for a deeper analysis on the elements’ layout. The authors research represents the abilities of modern UML modelling tools to offer automatic layout of the UML sequence diagram and analyse them according to criteria required for the diagram perception.

  15. Advances in the analysis and characterization of DLC coatings

    Energy Technology Data Exchange (ETDEWEB)

    Bellido-Gonzalez, V.; Hampshire, J.; Jones, A.H.S.; Allen, T.J.; Witts, J.; Teer, D.G.; Pierret, B. [Teer Coatings Ltd., Hartlebury Trading Estate, Worcestershire (United Kingdom)

    1998-01-01

    A series of new DLC coatings have been produced by magnetron sputtering using standard in-house equipment. Different tests have been carried out for the analysis and characterization of the coatings. By combining ball cratering with pin-on-disc, standard scratch and multiscratch tests, interesting information has been obtained (failure mechanism, wear properties, etc.). In addition, in combination with ball cratering, a novel method has been developed for the assessment of the refractive index of transparent and semi-transparent DLC films. In the pin-on-disc and multiscratch tests, the conductivity of the film was used to follow the wear progression (DLC has a relatively low electrical conductivity). This device can show local failures produced in the coating (indicated by an increase of film conductivity) which normally remains undetected in a frictional record. (orig.) 14 refs.

  16. Advanced spectral analysis of ionospheric waves observed with sparse arrays

    CERN Document Server

    Helmboldt, Joseph

    2014-01-01

    This paper presents a case study from a single, six-hour observing period to illustrate the application of techniques developed for interferometric radio telescopes to the spectral analysis of observations of ionospheric fluctuations with sparse arrays. We have adapted the deconvolution methods used for making high dynamic range images of cosmic sources with radio arrays to making comparably high dynamic range maps of spectral power of wavelike ionospheric phenomena. In the example presented here, we have used observations of the total electron content (TEC) gradient derived from Very Large Array (VLA) observations of synchrotron emission from two galaxy clusters at 330 MHz as well as GPS-based TEC measurements from a sparse array of 33 receivers located within New Mexico near the VLA. We show that these techniques provide a significant improvement in signal to noise (S/N) of detected wavelike structures by correcting for both measurement inaccuracies and wavefront distortions. This is especially true for the...

  17. Advanced accident sequence precursor analysis level 1 models

    Energy Technology Data Exchange (ETDEWEB)

    Sattison, M.B.; Thatcher, T.A.; Knudsen, J.K.; Schroeder, J.A.; Siu, N.O. [Idaho National Engineering Lab., Idaho National Lab., Idaho Falls, ID (United States)

    1996-03-01

    INEL has been involved in the development of plant-specific Accident Sequence Precursor (ASP) models for the past two years. These models were developed for use with the SAPHIRE suite of PRA computer codes. They contained event tree/linked fault tree Level 1 risk models for the following initiating events: general transient, loss-of-offsite-power, steam generator tube rupture, small loss-of-coolant-accident, and anticipated transient without scram. Early in 1995 the ASP models were revised based on review comments from the NRC and an independent peer review. These models were released as Revision 1. The Office of Nuclear Regulatory Research has sponsored several projects at the INEL this fiscal year to further enhance the capabilities of the ASP models. Revision 2 models incorporates more detailed plant information into the models concerning plant response to station blackout conditions, information on battery life, and other unique features gleaned from an Office of Nuclear Reactor Regulation quick review of the Individual Plant Examination submittals. These models are currently being delivered to the NRC as they are completed. A related project is a feasibility study and model development of low power/shutdown (LP/SD) and external event extensions to the ASP models. This project will establish criteria for selection of LP/SD and external initiator operational events for analysis within the ASP program. Prototype models for each pertinent initiating event (loss of shutdown cooling, loss of inventory control, fire, flood, seismic, etc.) will be developed. A third project concerns development of enhancements to SAPHIRE. In relation to the ASP program, a new SAPHIRE module, GEM, was developed as a specific user interface for performing ASP evaluations. This module greatly simplifies the analysis process for determining the conditional core damage probability for a given combination of initiating events and equipment failures or degradations.

  18. Advances in multiscale theoretical analysis and imaging aspects of turbulence

    Science.gov (United States)

    Shockro, Jennifer

    The work presented in this dissertation is focused on two aspects related to turbulent flow. The first of these is the one-dimensional theoretical analysis of the logarithmic spiral in terms of fractal dimension and spectrum. The second is on imaging methodologies and analysis of turbulent jet scalar interfaces in atmospheric conditions, with broad applicability to various studies where turbulence has a key role, such as urban contaminant dispersion or free space laser communications. The logarithmic spiral is of particular interest to studies of turbulence and natural phenomena as it appears frequently in nature with the "Golden Ratio" and is thought to play an important role in turbulent mixing. It is also an inherently anisotropic geometric structure and therefore provides information towards examining phenomena in which anisotropic properties might be expected to appear and is thought to be present as a structure within the fine scales of the turbulent hierarchy. In this work it is subjected to one-dimensional theoretical analysis, focusing on the development of a probability density function (pdf) for the spiral and the relation of the pdf to its fractal dimension. Results indicate that the logarithmic spiral does not have a constant fractal dimension and thus that it does not exhibit any form of self-similar statistical behavior, supporting previous theoretical suppositions about behavior at the fine scales within the turbulent hierarchy. A signal is developed from the pdf in order to evaluate its power spectrum. Results of this analysis provide information about the manner in which energy is carried at different scales of the spiral. To our knowledge, the logarithmic spiral in particular has not yet been examined in this fashion in literature. In order to further investigate this object, the multiscale minima meshless (M(3) ) method isextended and employed computationally to the two-dimensional logarithmic spiral as well as to experimental images of a

  19. Advanced Thermal Simulator Testing: Thermal Analysis and Test Results

    Science.gov (United States)

    Bragg-Sitton, Shannon M.; Dickens, Ricky; Dixon, David; Reid, Robert; Adams, Mike; Davis, Joe

    2008-01-01

    Work at the NASA Marshall Space Flight Center seeks to develop high fidelity, electrically heated thermal simulators that represent fuel elements in a nuclear reactor design to support non-nuclear testing applicable to the development of a space nuclear power or propulsion system. Comparison between the fuel pins and thermal simulators is made at the outer fuel clad surface, which corresponds to the outer sheath surface in the thermal simulator. The thermal simulators that are currently being tested correspond to a SNAP derivative reactor design that could be applied for Lunar surface power. These simulators are designed to meet the geometric and power requirements of a proposed surface power reactor design, accommodate testing of various axial power profiles, and incorporate imbedded instrumentation. This paper reports the results of thermal simulator analysis and testing in a bare element configuration, which does not incorporate active heat removal, and testing in a water-cooled calorimeter designed to mimic the heat removal that would be experienced in a reactor core.

  20. Advanced spectral analysis of ionospheric waves observed with sparse arrays

    Science.gov (United States)

    Helmboldt, J. F.; Intema, H. T.

    2014-02-01

    This paper presents a case study from a single, 6h observing period to illustrate the application of techniques developed for interferometric radio telescopes to the spectral analysis of observations of ionospheric fluctuations with sparse arrays. We have adapted the deconvolution methods used for making high dynamic range images of cosmic sources with radio arrays to making comparably high dynamic range maps of spectral power of wavelike ionospheric phenomena. In the example presented here, we have used observations of the total electron content (TEC) gradient derived from Very Large Array (VLA) observations of synchrotron emission from two galaxy clusters at 330MHz as well as GPS-based TEC measurements from a sparse array of 33 receivers located within New Mexico near the VLA. We show that these techniques provide a significant improvement in signal-to-noise ratio (S/N) of detected wavelike structures by correcting for both measurement inaccuracies and wavefront distortions. This is especially true for the GPS data when combining all available satellite/receiver pairs, which probe a larger physical area and likely have a wider variety of measurement errors than in the single-satellite case. In this instance, we found that the peak S/N of the detected waves was improved by more than an order of magnitude. The data products generated by the deconvolution procedure also allow for a reconstruction of the fluctuations as a two-dimensional waveform/phase screen that can be used to correct for their effects.

  1. Advances to Dynamic Mechanical Analysis: High Frequencies and Environmental Applications

    Science.gov (United States)

    Foreman, Jonathon

    2002-03-01

    In dynamic mechanical analysis (DMA) the sample is deformed and released sinusoidally providing information about the modulus and damping behaviors with respect to temperature, time, oscillation frequency and amplitude of motion. It offers exceptional sensitivity to glass transitions and secondary relaxations. Recent developments have increased the frequency range up to 1000 Hz, which allow properties measurements under actual end-use conditions. Furthermore high frequencies enhance the ability to determine the kinetics of viscoelastic relaxations. Another recent development allows DMA measurements while samples are immersed in fluids or enveloped in gases. Most significant is the ability to alter the furnace control parameters to account for the thermal properties of the environment used. This configuration allows temperature-controlled measurements (both heating and isothermal profiles) on a wide range of sample shapes and sizes. Environmental DMA is easier to interpret than standard DMA (in air or inert gas) on preconditioned samples because such samples often lose the conditioning solvent or gas during the measurement. easy.com/dma_apps.asp>Examples will show real-time property changes from the interaction of unconditioned materials with conditioning environments and experiments on pre-conditioned materials that are heated while immersed in conditioning environments. -------------------------------------------------------------

  2. Modeling and Analysis in Marine Big Data: Advances and Challenges

    Directory of Open Access Journals (Sweden)

    Dongmei Huang

    2015-01-01

    Full Text Available It is aware that big data has gathered tremendous attentions from academic research institutes, governments, and enterprises in all aspects of information sciences. With the development of diversity of marine data acquisition techniques, marine data grow exponentially in last decade, which forms marine big data. As an innovation, marine big data is a double-edged sword. On the one hand, there are many potential and highly useful values hidden in the huge volume of marine data, which is widely used in marine-related fields, such as tsunami and red-tide warning, prevention, and forecasting, disaster inversion, and visualization modeling after disasters. There is no doubt that the future competitions in marine sciences and technologies will surely converge into the marine data explorations. On the other hand, marine big data also brings about many new challenges in data management, such as the difficulties in data capture, storage, analysis, and applications, as well as data quality control and data security. To highlight theoretical methodologies and practical applications of marine big data, this paper illustrates a broad view about marine big data and its management, makes a survey on key methods and models, introduces an engineering instance that demonstrates the management architecture, and discusses the existing challenges.

  3. Advanced response surface method for mechanical reliability analysis

    Institute of Scientific and Technical Information of China (English)

    L(U) Zhen-zhou; ZHAO Jie; YUE Zhu-feng

    2007-01-01

    Based on the classical response surface method (RSM), a novel RSM using improved experimental points (EPs) is presented for reliability analysis. Two novel points are included in the presented method. One is the use of linear interpolation, from which the total EPs for determining the RS are selected to be closer to the actual failure surface;the other is the application of sequential linear interpolation to control the distance between the surrounding EPs and the center EP, by which the presented method can ensure that the RS fits the actual failure surface in the region of maximum likelihood as the center EPs converge to the actual most probable point (MPP). Since the fitting precision of the RS to the actual failure surface in the vicinity of the MPP, which has significant contribution to the probability of the failure surface being exceeded, is increased by the presented method, the precision of the failure probability calculated by RS is increased as well. Numerical examples illustrate the accuracy and efficiency of the presented method.

  4. An advanced machining simulation environment employing workpiece structural analysis

    Directory of Open Access Journals (Sweden)

    A.A. Becker

    2006-04-01

    Full Text Available Purpose: The study aims to reduce the surface dimensional error due to the part deflection during the machining of thin wall structures, thus, reduce machining costs and lead times by producing “right first time” components.Design/methodology/approach: The proposed simulation environment involves a data model, an analytical force prediction model, a material removal model and an FE analysis commercial software package. It focuses on the development of the simulation environment with a multi-level machining error compensation approach.Findings: The developed simulation environment can predict and reduce the form error, which is a limitation of the existing approaches.Research limitations/implications: The energy consumption, temperature change and residual stress are not studied in this research.Practical implications: The developed method provides a platform to deliver new functionality for machining process simulation. The convergence of the proposed integrated system can be achieved quickly after only a few iterations, which makes the methodology reliable and efficient.Originality/value: The study offers an opportunity to satisfy tight tolerances, eliminate hand-finishing processes and assure part-to-part accuracy at the right first time, which is a limitation of previous approaches.

  5. Analysis of Advanced Respiratory Support Onboard ISS and CCV

    Science.gov (United States)

    Shah, Ronak V.; Kertsman, Eric L.; Alexander, David J.; Duchesne, Ted; Law, Jennifer; Roden, Sean K.

    2014-01-01

    NASA is collaborating with private entities for the development of commercial space vehicles. The Space and Clinical Operations Division was tasked to review the oxygen and respiratory support system and recommend what capabilities, if any, the vehicle should have to support the return of an ill or injured crewmember. The Integrated Medical Model (IMM) was utilized as a data source for the development of these recommendations. The Integrated Medical Model (IMM) was used to simulate a six month, six crew, International Space Station (ISS) mission. Three medical system scenarios were considered based on the availability of (1) oxygen only, (2) oxygen and a ventilator, or (3) neither oxygen nor ventilator. The IMM analysis provided probability estimates of medical events that would require either oxygen or ventilator support. It also provided estimates of crew health, the probability of evacuation, and the probability of loss of crew life secondary to medical events for each of the three medical system scenarios. These IMM outputs were used as objective data to enable evidence-based decisions regarding oxygen and respiratory support system requirements for commercial crew vehicles. The IMM provides data that may be utilized to support informed decisions regarding the development of medical systems for commercial crew vehicles.

  6. Advanced microgrid design and analysis for forward operating bases

    Science.gov (United States)

    Reasoner, Jonathan

    This thesis takes a holistic approach in creating an improved electric power generation system for a forward operating base (FOB) in the future through the design of an isolated microgrid. After an extensive literature search, this thesis found a need for drastic improvement of the FOB power system. A thorough design process analyzed FOB demand, researched demand side management improvements, evaluated various generation sources and energy storage options, and performed a HOMERRTM discrete optimization to determine the best microgrid design. Further sensitivity analysis was performed to see how changing parameters would affect the outcome. Lastly, this research also looks at some of the challenges which are associated with incorporating a design which relies heavily on inverter-based generation sources, and gives possible solutions to help make a renewable energy powered microgrid a reality. While this thesis uses a FOB as the case study, the process and discussion can be adapted to aide in the design of an off-grid small-scale power grid which utilizes high-penetration levels of renewable energy.

  7. Advances in directional borehole radar data analysis and visualization

    Science.gov (United States)

    Smith, D.V.G.; Brown, P.J.

    2002-01-01

    The U.S. Geological Survey is developing a directional borehole radar (DBOR) tool for mapping fractures, lithologic changes, and underground utility and void detection. An important part of the development of the DBOR tool is data analysis and visualization, with the aim of making the software graphical user interface (GUI) intuitive and easy to use. The DBOR software system consists of a suite of signal and image processing routines written in Research Systems' Interactive Data Language (IDL). The software also serves as a front-end to many widely accepted Colorado School of Mines Center for Wave Phenomena (CWP) Seismic UNIX (SU) algorithms (Cohen and Stockwell, 2001). Although the SU collection runs natively in a UNIX environment, our system seamlessly emulates a UNIX session within a widely used PC operating system (MicroSoft Windows) using GNU tools (Noer, 1998). Examples are presented of laboratory data acquired with the prototype tool from two different experimental settings. The first experiment imaged plastic pipes in a macro-scale sand tank. The second experiment monitored the progress of an invasion front resulting from oil injection. Finally, challenges to further development and planned future work are discussed.

  8. Advancing Collaborative Climate Studies through Globally Distributed Geospatial Analysis

    Science.gov (United States)

    Singh, R.; Percivall, G.

    2009-12-01

    Infrastructure and the broader GEOSS architecture. Of specific interest to this session is the work on geospatial workflows and geo-processing and data discovery and access. CCIP demonstrates standards-based interoperability between geospatial applications in the service of Climate Change analysis. CCIP is planned to be a yearly exercise. It consists of a network of online data services (WCS, WFS, SOS), analysis services (WPS, WCPS, WMS), and clients that exercise those services. In 2009, CCIP focuses on Australia, and the initial application of existing OGC services to climate studies. The results of the 2009 CCIP will serve as requirements for more complex geo-processing services to be developed for CCIP 2010. The benefits of CCIP include accelerating the implementation of the GCOS, and building confidence that implementations using multi-vendor interoperable technologies can help resolve vexing climate change questions. AIP-2: Architecture Implementation Pilot, Phase 2 CCIP: Climate Challenge Integration Plugfest GEO: Group on Earth Observations GEOSS: Global Earth Observing System of Systems GCOS: Global Climate Observing System OGC: Open Geospatial Consortium SOS: Sensor Observation Service WCS: Web Coverage Service WCPS: Web Coverage Processing Service WFS: Web Feature Service WMS: Web Mapping Service

  9. Interglacial climate dynamics and advanced time series analysis

    Science.gov (United States)

    Mudelsee, Manfred; Bermejo, Miguel; Köhler, Peter; Lohmann, Gerrit

    2013-04-01

    Studying the climate dynamics of past interglacials (IGs) helps to better assess the anthropogenically influenced dynamics of the current IG, the Holocene. We select the IG portions from the EPICA Dome C ice core archive, which covers the past 800 ka, to apply methods of statistical time series analysis (Mudelsee 2010). The analysed variables are deuterium/H (indicating temperature) (Jouzel et al. 2007), greenhouse gases (Siegenthaler et al. 2005, Loulergue et al. 2008, L¨ü thi et al. 2008) and a model-co-derived climate radiative forcing (Köhler et al. 2010). We select additionally high-resolution sea-surface-temperature records from the marine sedimentary archive. The first statistical method, persistence time estimation (Mudelsee 2002) lets us infer the 'climate memory' property of IGs. Second, linear regression informs about long-term climate trends during IGs. Third, ramp function regression (Mudelsee 2000) is adapted to look on abrupt climate changes during IGs. We compare the Holocene with previous IGs in terms of these mathematical approaches, interprete results in a climate context, assess uncertainties and the requirements to data from old IGs for yielding results of 'acceptable' accuracy. This work receives financial support from the Deutsche Forschungsgemeinschaft (Project ClimSens within the DFG Research Priority Program INTERDYNAMIK) and the European Commission (Marie Curie Initial Training Network LINC, No. 289447, within the 7th Framework Programme). References Jouzel J, Masson-Delmotte V, Cattani O, Dreyfus G, Falourd S, Hoffmann G, Minster B, Nouet J, Barnola JM, Chappellaz J, Fischer H, Gallet JC, Johnsen S, Leuenberger M, Loulergue L, Luethi D, Oerter H, Parrenin F, Raisbeck G, Raynaud D, Schilt A, Schwander J, Selmo E, Souchez R, Spahni R, Stauffer B, Steffensen JP, Stenni B, Stocker TF, Tison JL, Werner M, Wolff EW (2007) Orbital and millennial Antarctic climate variability over the past 800,000 years. Science 317:793. Köhler P, Bintanja R

  10. Advanced morphological analysis of patterns of thin anodic porous alumina

    Energy Technology Data Exchange (ETDEWEB)

    Toccafondi, C. [Istituto Italiano di Tecnologia, Department of Nanophysics, Via Morego 30, Genova I 16163 (Italy); Istituto Italiano di Tecnologia, Department of Nanostructures, Via Morego 30, Genova I 16163 (Italy); Stępniowski, W.J. [Department of Advanced Materials and Technologies, Faculty of Advanced Technologies and Chemistry, Military University of Technology, 2 Kaliskiego Str., 00-908 Warszawa (Poland); Leoncini, M. [Istituto Italiano di Tecnologia, Department of Nanostructures, Via Morego 30, Genova I 16163 (Italy); Salerno, M., E-mail: marco.salerno@iit.it [Istituto Italiano di Tecnologia, Department of Nanophysics, Via Morego 30, Genova I 16163 (Italy)

    2014-08-15

    Different conditions of fabrication of thin anodic porous alumina on glass substrates have been explored, obtaining two sets of samples with varying pore density and porosity, respectively. The patterns of pores have been imaged by high resolution scanning electron microscopy and analyzed by innovative methods. The regularity ratio has been extracted from radial profiles of the fast Fourier transforms of the images. Additionally, the Minkowski measures have been calculated. It was first observed that the regularity ratio averaged across all directions is properly corrected by the coefficient previously determined in the literature. Furthermore, the angularly averaged regularity ratio for the thin porous alumina made during short single-step anodizations is lower than that of hexagonal patterns of pores as for thick porous alumina from aluminum electropolishing and two-step anodization. Therefore, the regularity ratio represents a reliable measure of pattern order. At the same time, the lower angular spread of the regularity ratio shows that disordered porous alumina is more isotropic. Within each set, when changing either pore density or porosity, both regularity and isotropy remain rather constant, showing consistent fabrication quality of the experimental patterns. Minor deviations are tentatively discussed with the aid of the Minkowski measures, and the slight decrease in both regularity and isotropy for the final data-points of the porosity set is ascribed to excess pore opening and consequent pore merging. - Highlights: • Thin porous alumina is partly self-ordered and pattern analysis is required. • Regularity ratio is often misused: we fix the averaging and consider its spread. • We also apply the mathematical tool of Minkowski measures, new in this field. • Regularity ratio shows pattern isotropy and Minkowski helps in assessment. • General agreement with perfect artificial patterns confirms the good manufacturing.

  11. Specification, Design, and Analysis of Advanced HUMS Architectures

    Science.gov (United States)

    Mukkamala, Ravi

    2004-01-01

    During the two-year project period, we have worked on several aspects of domain-specific architectures for HUMS. In particular, we looked at using scenario-based approach for the design and designed a language for describing such architectures. The language is now being used in all aspects of our HUMS design. In particular, we have made contributions in the following areas. 1) We have employed scenarios in the development of HUMS in three main areas. They are: (a) To improve reusability by using scenarios as a library indexing tool and as a domain analysis tool; (b) To improve maintainability by recording design rationales from two perspectives - problem domain and solution domain; (c) To evaluate the software architecture. 2) We have defined a new architectural language called HADL or HUMS Architectural Definition Language. It is a customized version of xArch/xADL. It is based on XML and, hence, is easily portable from domain to domain, application to application, and machine to machine. Specifications written in HADL can be easily read and parsed using the currently available XML parsers. Thus, there is no need to develop a plethora of software to support HADL. 3) We have developed an automated design process that involves two main techniques: (a) Selection of solutions from a large space of designs; (b) Synthesis of designs. However, the automation process is not an absolute Artificial Intelligence (AI) approach though it uses a knowledge-based system that epitomizes a specific HUMS domain. The process uses a database of solutions as an aid to solve the problems rather than creating a new design in the literal sense. Since searching is adopted as the main technique, the challenges involved are: (a) To minimize the effort in searching the database where a very large number of possibilities exist; (b) To develop representations that could conveniently allow us to depict design knowledge evolved over many years; (c) To capture the required information that aid the

  12. Advancements in 3D Structural Analysis of Geothermal Systems

    Energy Technology Data Exchange (ETDEWEB)

    Siler, Drew L [Nevada Bureau of Mines and Geology, University of Nevada, Reno; Faulds, James E [Nevada Bureau of Mines and Geology, University of Nevada, Reno; Mayhew, Brett [Nevada Bureau of Mines and Geology, University of Nevada, Reno; McNamara, David [Department of Geothermal Science, GNS Science, NZ

    2013-06-23

    Robust geothermal activity in the Great Basin, USA is a product of both anomalously high regional heat flow and active fault-controlled extension. Elevated permeability associated with some fault systems provides pathways for circulation of geothermal fluids. Constraining the local-scale 3D geometry of these structures and their roles as fluid flow conduits is crucial in order to mitigate both the costs and risks of geothermal exploration and to identify blind (no surface expression) geothermal resources. Ongoing studies have indicated that much of the robust geothermal activity in the Great Basin is associated with high density faulting at structurally complex fault intersection/interaction areas, such as accommodation/transfer zones between discrete fault systems, step-overs or relay ramps in fault systems, intersection zones between faults with different strikes or different senses of slip, and horse-tailing fault terminations. These conceptualized models are crucial for locating and characterizing geothermal systems in a regional context. At the local scale, however, pinpointing drilling targets and characterizing resource potential within known or probable geothermal areas requires precise 3D characterization of the system. Employing a variety of surface and subsurface data sets, we have conducted detailed 3D geologic analyses of two Great Basin geothermal systems. Using EarthVision (Dynamic Graphics Inc., Alameda, CA) we constructed 3D geologic models of both the actively producing Brady’s geothermal system and a ‘greenfield’ geothermal prospect at Astor Pass, NV. These 3D models allow spatial comparison of disparate data sets in 3D and are the basis for quantitative structural analyses that can aid geothermal resource assessment and be used to pinpoint discrete drilling targets. The relatively abundant data set at Brady’s, ~80 km NE of Reno, NV, includes 24 wells with lithologies interpreted from careful analysis of cuttings and core, a 1

  13. Teaching Advanced Data Analysis Tools to High School Astronomy Students

    Science.gov (United States)

    Black, David V.; Herring, Julie; Hintz, Eric G.

    2015-01-01

    A major barrier to becoming an astronomer is learning how to analyze astronomical data, such as using photometry to compare the brightness of stars. Most fledgling astronomers learn observation, data reduction, and analysis skills through an upper division college class. If the same skills could be taught in an introductory high school astronomy class, then more students would have an opportunity to do authentic science earlier, with implications for how many choose to become astronomers. Several software tools have been developed that can analyze astronomical data ranging from fairly straightforward (AstroImageJ and DS9) to very complex (IRAF and DAOphot). During the summer of 2014, a study was undertaken at Brigham Young University through a Research Experience for Teachers (RET) program to evaluate the effectiveness and ease-of-use of these four software packages. Standard tasks tested included creating a false-color IR image using WISE data in DS9, Adobe Photoshop, and The Gimp; a multi-aperture analyses of variable stars over time using AstroImageJ; creating Spectral Energy Distributions (SEDs) of stars using photometry at multiple wavelengths in AstroImageJ and DS9; and color-magnitude and hydrogen alpha index diagrams for open star clusters using IRAF and DAOphot. Tutorials were then written and combined with screen captures to teach high school astronomy students at Walden School of Liberal Arts in Provo, UT how to perform these same tasks. They analyzed image data using the four software packages, imported it into Microsoft Excel, and created charts using images from BYU's 36-inch telescope at their West Mountain Observatory. The students' attempts to complete these tasks were observed, mentoring was provided, and the students then reported on their experience through a self-reflection essay and concept test. Results indicate that high school astronomy students can successfully complete professional-level astronomy data analyses when given detailed

  14. Quantitative analysis of autophagy using advanced 3D fluorescence microscopy.

    Science.gov (United States)

    Changou, Chun A; Wolfson, Deanna L; Ahluwalia, Balpreet Singh; Bold, Richard J; Kung, Hsing-Jien; Chuang, Frank Y S

    2013-05-03

    stages of autophagy induction. With commercially available digital image analysis applications, we can readily obtain statistical information about autophagosome and lysosome number, size, distribution, and degree of colocalization from any imaged cell. This information allows us to precisely track the progress of autophagy in living cells and enables our continued investigation into the role of autophagy in cancer chemotherapy.

  15. Laparoscopic splenectomy: the latest technical evaluation

    Institute of Scientific and Technical Information of China (English)

    Min Tan; Chao-Xu Zheng; Zhi-Mian Wu; Guo-Tai Chen; Liu-Hua Chen; Zhen-Xian Zhao

    2003-01-01

    AIM: To introduce our latest innovation on technical manipulation of laparoscopic splenectomy.METHODS: Under general anesthesia and carbon dioxide (CO2) pneumoperitoneum, 86 cases of laparoscopic splenectomy (LS) were performed. The patients were placed in three different operative positions: 7 cases in the lithotomic position, 31 cases in the right recumbent position and 48cases in the right lateral position. An ultrasonic scissors was used to dissect the pancreaticosplenic ligament, the splenocolicum ligament, lienorenal ligament and the lienophrenic ligament, respectively. Lastly, the gastrosplenic ligament and short gastric vessels were dissected. The splenic artery and vein were resected at splenic hilum with EndoGIA. The impact of different operative positions, spleen size and other events during the operation were studied.RESULTS: The laparoscopic splenectomy was successfully performed on all 86 patients from August 1997 to August 2002. No operative complications, such as peritoneal cavity infection, massive bleeding after operation and adjacent organs injured were observed. There was no death related to the operation. The study showed that different operative positions could significantly influence the manipulation of LS. The right lateral position had more advantages than the lithotomic position and the right recumbent position in LS.CONCLUSION: Most cases of LS could be accomplishedsuccessfully when patients are placed in the right lateral position. The right lateral position has more advantages than the conventional supine approach by providing a more direct view of the splenic hilum as well as other important anatomies. Regardless of operation positions, the major axis of spleen exceeding 15 cm by B-ultrasound in vitro will surely increase the difficulties of LS and therefore prolong the duration of operation. LS is a safe and feasible modality for splenectomy.

  16. The latest IceCube results

    Energy Technology Data Exchange (ETDEWEB)

    Mase, K.

    2014-12-01

    The IceCube detector is unique. It uses the Antarctic glacial ice as an interaction and detection medium. An array of optical sensors observes Cherenkov light from secondary charged particles resulting from neutrino interactions. The high transparency of the ice enabled the realization of a 1 km{sup 3} large detection volume in order to detect rarely interacting particles. Neutrinos are ideal probes of the deep universe because they rarely interact with matter and propagate in straight lines. Neutrinos are thought to be produced in hadronic processes at astronomical sources such as active galactic nuclei and gamma-ray bursts. IceCube aims to detect neutrinos from such astronomical sources. IceCube recently found 28 events in an energy range approximately from 50 TeV to 1 PeV. These events are not easily explained by background derived from atmospheric origin, and therefore represent the first evidence for high energy neutrinos from an extraterrestrial origin. IceCube can also perform elementary particle physics by searching for neutrinos from SUSY particles such as neutralinos and measuring atmospheric neutrino oscillations. An overview of the latest IceCube results is provided in this paper including the 28 candidate observations and the corresponding implications. - Highlights: • IceCube has been completed and it is performing as expected. • Two PeV events were observed and the follow-up search found an additional 26 events. • This is the first evidence of an extraterrestrial high-energy neutrino flux above 50 TeV. • IceCube can also perform elementary particle physics.

  17. Advanced approaches to characterize the human intestinal microbiota by computational meta-analysis

    NARCIS (Netherlands)

    Nikkilä, J.; Vos, de W.M.

    2010-01-01

    GOALS: We describe advanced approaches for the computational meta-analysis of a collection of independent studies, including over 1000 phylogenetic array datasets, as a means to characterize the variability of human intestinal microbiota. BACKGROUND: The human intestinal microbiota is a complex micr

  18. Advances in thermal hydraulic and neutronic simulation for reactor analysis and safety

    Energy Technology Data Exchange (ETDEWEB)

    Tentner, A.M.; Blomquist, R.N.; Canfield, T.R.; Ewing, T.F.; Garner, P.L.; Gelbard, E.M.; Gross, K.C.; Minkoff, M.; Valentin, R.A.

    1993-03-01

    This paper describes several large-scale computational models developed at Argonne National Laboratory for the simulation and analysis of thermal-hydraulic and neutronic events in nuclear reactors and nuclear power plants. The impact of advanced parallel computing technologies on these computational models is emphasized.

  19. Advanced GIS Exercise: Performing Error Analysis in ArcGIS ModelBuilder

    Science.gov (United States)

    Hall, Steven T.; Post, Christopher J.

    2009-01-01

    Knowledge of Geographic Information Systems is quickly becoming an integral part of the natural resource professionals' skill set. With the growing need of professionals with these skills, we created an advanced geographic information systems (GIS) exercise for students at Clemson University to introduce them to the concept of error analysis,…

  20. Proceedings: Workshop on Advanced Mathematics and Computer Science for Power Systems Analysis

    Energy Technology Data Exchange (ETDEWEB)

    None

    1991-08-01

    EPRI's Office of Exploratory Research sponsors a series of workshops that explore how to apply recent advances in mathematics and computer science to the problems of the electric utility industry. In this workshop, participants identified research objectives that may significantly improve the mathematical methods and computer architecture currently used for power system analysis.

  1. Advanced exergy analysis of a R744 booster refrigeration system with parallel compression

    DEFF Research Database (Denmark)

    Gullo, Paride; Elmegaard, Brian; Cortella, Giovanni

    2016-01-01

    In this paper, the advanced exergy analysis was applied to a R744 booster refrigeration system with parallel compression taking into account the design external temperatures of 25 degrees C and 35 degrees C, as well as the operating conditions of a conventional European supermarket. The global...

  2. On the anomalies in the latest LHCb data

    Directory of Open Access Journals (Sweden)

    T. Hurth

    2016-08-01

    Full Text Available Depending on the assumptions on the power corrections to the exclusive b→sℓ+ℓ− decays, the latest data of the LHCb Collaboration – based on the 3 fb−1 data set and on two different experimental analysis methods – still shows some tensions with the Standard Model predictions. We present a detailed analysis of the theoretical inputs and various global fits to all the available b→sℓ+ℓ− data. This constitutes the first global analysis of the new data of the LHCb Collaboration based on the hypothesis that these tensions can be at least partially explained by new physics contributions. In our model-independent analysis we present one-, two-, four-, and also five-dimensional global fits in the space of Wilson coefficients to all available b→sℓ+ℓ− data. We also compare the two different experimental LHCb analyses of the angular observables in B→K⁎μ+μ−. We explicitly analyse the dependence of our results on the assumptions about power corrections, but also on the errors present in the form factor calculations. Moreover, based on our new global fits we present predictions for ratios of observables which may show a sign of lepton non-universality. Their measurements would crosscheck the LHCb result on the ratio RK=BR(B+→K+μ+μ−/BR(B+→K+e+e− in the low-q2 region which deviates from the SM prediction by 2.6σ.

  3. On the anomalies in the latest LHCb data

    CERN Document Server

    Hurth, T; Neshatpour, S

    2016-01-01

    Depending on the assumptions on the power corrections to the exclusive b -> s l+ l- decays, the latest data of the LHCb collaboration - based on the 3 fb^-1 data set and on two different experimental analysis methods - still shows some tensions with the SM predictions. We present a detailed analysis of the theoretical inputs and various global fits to all the available b -> s l+ l- data. This constitutes the first global analysis of the new data of the LHCb collaboration based on the hypothesis that these tensions can be at least partially explained by new physics contributions. In our model-independent analysis we present one-, two-, four-, and also five-dimensional global fits in the space of Wilson coefficients to all available b -> s l+ l- data. We also compare the two different experimental LHCb analyses of the angular observables in B -> K* mu+ mu-. We explicitly analyse the dependence of our results on the assumptions about power corrections, but also on the errors present in the form factor calculatio...

  4. Advanced duodenal carcinoma:Chemotherapy efficacy and analysis of prognostic factors

    Institute of Scientific and Technical Information of China (English)

    Junbao Liu; Nan Wang; Wei Liu; Chengxu Cui; Lifang Yuan; Jinwan Wang; Shuping Shi; Zhujun Shao; Haijian Tang; Tingting Yang; Chunhui Gao

    2016-01-01

    Objective This study aimed to determine the ef icacy of chemotherapy and to identify potential chemo-therapy agents to treat advanced primary duodenal carcinoma (PDC). Methods Seventy-three patients with advanced PDC were included in the study. Response rate (RR), disease control rate (DCR), progression-free survival (PFS), overal survival (OS) and prognosis were com-pared among patients using the Cox proportional hazards model. Results The overal RR and DCR of 52 patients were 21.15% and 69.23%, respectively. The median PFS and OS times were 4.51 and 11.47 months, respectively. Pal iative chemotherapy improved the OS of patients with advanced PDC compared with patients who did not receive chemotherapy (14.28 months vs. 5.20 months, HR = 0.205, 95% CI: 0.077 to 0.547, P = 0.0016). Multivariate analysis indicated mucinous histology and liver metastasis as factors predictive of poor prognosis in patients with advanced PDC. Conclusion Pal iative chemotherapy may improve the OS of patients with advanced PDC. Mucinous histology and liver metastasis were the main prognostic factors in patients with advanced PDC.

  5. Electroencephalography when meditation advances: a case-based time-series analysis.

    Science.gov (United States)

    Tsai, Jui-Feng; Jou, Shaw-Hwa; Cho, WenChun; Lin, Chieh-Min

    2013-11-01

    Increased alpha and theta activities in electroencephalography (EEG) have been found during various forms of meditation. However, advanced stage of meditation drew less attention to date. We aimed at exploring EEG characteristics during advanced meditation. Bilateral absolute alpha and theta EEG powers were recorded when a single meditator at rest, exercising breath meditation, and reaching the advanced meditative stage in 10 sessions of meditation. Averaged time-series data were analyzed using simulation modeling analysis to compare the powers during different meditative phases. During breath meditation, significantly higher activities compared with baseline were found only in bilateral theta (P = 0.0406, 0.0158 for left and right sides, respectively), but not in alpha (P = 0.1412, 0.0978 for left and right sides, respectively) bands. When meditation advanced, significantly increased activities were found both in bilateral alpha (P = 0.0218, 0.0258 for left and right sides, respectively) and theta (P = 0.0308, 0.0260 for left and right sides, respectively) bands compared against breath meditation. When advanced meditation compared against baseline, bilateral alpha (P = 0.0001, 0.0001 for left and right sides, respectively) and theta (P = 0.0001, 0.0001 for left and right sides, respectively) bands revealed significantly increased activities. Our findings support that internalized attention manifested as theta activity continuingly enhances significantly in sequential phases of meditation, while relaxation manifested as alpha activity is significant only after the advanced meditative phase is reached.

  6. Analysis of Poverty Alleviation Model of Advancing Entire Villages——A Case Study of Ningxia

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    This paper gives an overview of the development-oriented poverty alleviation of advancing entire villages in Ningxia, and then relates the implementation of "1 000-village poverty alleviation program" of Ningxia by stages as follows: at the first stage (2005-2006), 203 villages began to implement the first development-oriented poverty alleviation program of advancing entire villages; at the second stage (2007-2008), the second development-oriented poverty alleviation program of advancing entire villages was implemented. By empirical analysis, the main experience in the process of implementing poverty alleviation model of advancing entire villages is generalized as follows: strengthen the support and help degree and frame feasible implementation planning; develop characteristic industries and expand export of labor services; support poor areas by using technology. Through five years of support, the poverty alleviation model of advancing entire villages achieves initial results: the specific sample survey shows that in the poor villages with smooth development of advancing entire villages and great investments, the farmers’ income per capita in whole village can be increased by more than 50% within one year or two years; due to the improvement of road, communication and other conditions, many poor villages can explore new possibilities for production, and better give play to the comparative advantages; the improvement of infrastructure also promotes export of labor services in the poor villages, so as to indirectly increase the income of farmers in poor villages.

  7. Latest Pleistocene Deposition and Erosion on the New Jersey Shelf

    Science.gov (United States)

    Christensen, B. A.; Alexander, C.; Stackhouse, S.; Turner, R.; Nordfjord, S.; Austin, J.; Goff, J.; Gulick, S.; Fulthorpe, C.

    2007-12-01

    The New Jersey margin is an ideal location for the study of sedimentary response to glacioeustatic forcing because this passive continental edge is both wide and stable. Although the region has been intensively imaged and mapped geophysically, it is still far from being understood stratigraphically because of a lack of samples to constrain timing and paleo-depositional environment. This study examines the timing and nature of latest Pleistocene erosion and deposition on the shelf, using grab samples and core recovered using the AHC-800 (Active Heave Compensation - 800 m) drilling system. The latest Pleistocene shelf is characterized by (1) downcutting and erosion by rivers associated with subaerial exposure during glacial retreat of sea level; (2) deposition at the shelf edge during sea level fall associated with formation of an outer shelf wedge; and (3) deposition in estuarine environments as sea level rose. Foraminiferal and sediment textural analyses of cores samples ground truth previous seismic reflection-based interpretations of incision and paleochannel formation. Grab samples analyzed for foraminiferal content and grain size identify environment of deposition within three main bathymetric features: sand ridges, sand ribbons, and glacial scours. Radiometric dating (14C) further constrains the timing of intervals of erosion and deposition. We relate our results to other studies and suggest a complex, spatially variable shelf response to glacial advance and retreat. K-Ar analyses of hornblende crystals provide constraints on sediment sources. Two assemblages exist: one consistent with ages of Proterozoic age plutons in the New Jersey area, and another, younger, indicating mixing. K-Ar dates show a clear difference between and Holocene (930- 970 +/- 20 Ma) sedimentary assemblages and sediments older than 30 k.y, (850-880 Ma +/- 20-30 Ma). Holocene hornblend crystal ages are consistent with Grenvillian aged plutons common to the source region (e

  8. Advancing Risk Analysis for Nanoscale Materials: Report from an International Workshop on the Role of Alternative Testing Strategies for Advancement.

    Science.gov (United States)

    Shatkin, J A; Ong, Kimberly J; Beaudrie, Christian; Clippinger, Amy J; Hendren, Christine Ogilvie; Haber, Lynne T; Hill, Myriam; Holden, Patricia; Kennedy, Alan J; Kim, Baram; MacDonell, Margaret; Powers, Christina M; Sharma, Monita; Sheremeta, Lorraine; Stone, Vicki; Sultan, Yasir; Turley, Audrey; White, Ronald H

    2016-08-01

    The Society for Risk Analysis (SRA) has a history of bringing thought leadership to topics of emerging risk. In September 2014, the SRA Emerging Nanoscale Materials Specialty Group convened an international workshop to examine the use of alternative testing strategies (ATS) for manufactured nanomaterials (NM) from a risk analysis perspective. Experts in NM environmental health and safety, human health, ecotoxicology, regulatory compliance, risk analysis, and ATS evaluated and discussed the state of the science for in vitro and other alternatives to traditional toxicology testing for NM. Based on this review, experts recommended immediate and near-term actions that would advance ATS use in NM risk assessment. Three focal areas-human health, ecological health, and exposure considerations-shaped deliberations about information needs, priorities, and the next steps required to increase confidence in and use of ATS in NM risk assessment. The deliberations revealed that ATS are now being used for screening, and that, in the near term, ATS could be developed for use in read-across or categorization decision making within certain regulatory frameworks. Participants recognized that leadership is required from within the scientific community to address basic challenges, including standardizing materials, protocols, techniques and reporting, and designing experiments relevant to real-world conditions, as well as coordination and sharing of large-scale collaborations and data. Experts agreed that it will be critical to include experimental parameters that can support the development of adverse outcome pathways. Numerous other insightful ideas for investment in ATS emerged throughout the discussions and are further highlighted in this article.

  9. Connecting Performance Analysis and Visualization to Advance Extreme Scale Computing (Dagstuhl Perspectives Workshop 14022)

    OpenAIRE

    Bremer, Peer-Timo; Mohr, Bernd; Pascucci, Valerio; Schulz, Martin

    2014-01-01

    In the first week of January 2014 Dagstuhl hosted a Perspectives Workshop on "Connecting Performance Analysis and Visualization to Advance Extreme Scale Computing". The event brought together two previously separate communities - from Visualization and HPC Performance Analysis - to discuss a long term joined research agenda. The goal was to identify and address the challenges in using visual representations to understand and optimize the performance of extreme-scale applications running...

  10. Creating a group profile through error analysis in advanced L2 translation training

    OpenAIRE

    HEANEY, Dermot

    2011-01-01

    Error analysis and product assessment are increasingly viewed as reductive procedures in translation pedagogy. In the current paper, a case is made for ‘rehabilitating’ error analysis, especially in advanced L2 translation teaching. Attention is drawn to its usefulness in creating a group profile for L2 translation trainees, particularly as regards the scope it offers for showing how aspects of linguistic transfer frequently considered marginal, when taken individually, are, on...

  11. Advances in Cancer Therapy

    OpenAIRE

    Jordan BF, Sonveaux P

    2011-01-01

    The book "Advances in Cancer Therapy" is a new addition to the Intech collection of books and aims at providing scientists and clinicians with a comprehensive overview of the state of current knowledge and latest research findings in the area of cancer therapy. For this purpose research articles, clinical investigations and review papers that are thought to improve the readers' understanding of cancer therapy developments and/or to keep them up to date with the most recent advances in this fi...

  12. Advanced functionality for radio analysis in the Offline software framework of the Pierre Auger Observatory

    CERN Document Server

    Abreu, P; Ahn, E J; Albuquerque, I F M; Allard, D; Allekotte, I; Allen, J; Allison, P; Castillo, J Alvarez; Alvarez-Muñiz, J; Ambrosio, M; Aminaei, A; Anchordoqui, L; Andringa, S; Antičić, T; Aramo, C; Arganda, E; Arqueros, F; Asorey, H; Assis, P; Aublin, J; Ave, M; Avenier, M; Avila, G; Bäcker, T; Balzer, M; Barber, K B; Barbosa, A F; Bardenet, R; Barroso, S L C; Baughman, B; Beatty, J J; Becker, B R; Becker, K H; Bellido, J A; BenZvi, S; Berat, C; Bertou, X; Biermann, P L; Billoir, P; Blanco, F; Blanco, M; Bleve, C; Blümer, H; Boháčová, M; Boncioli, D; Bonifazi, C; Bonino, R; Borodai, N; Brack, J; Brogueira, P; Brown, W C; Bruijn, R; Buchholz, P; Bueno, A; Burton, R E; Caballero-Mora, K S; Caramete, L; Caruso, R; Castellina, A; Cataldi, G; Cazon, L; Cester, R; Chauvin, J; Chiavassa, A; Chinellato, J A; Chou, A; Chudoba, J; Clay, R W; Coluccia, M R; Conceição, R; Contreras, F; Cook, H; Cooper, M J; Coppens, J; Cordier, A; Cotti, U; Coutu, S; Covault, C E; Creusot, A; Criss, A; Cronin, J; Curutiu, A; Dagoret-Campagne, S; Dallier, R; Dasso, S; Daumiller, K; Dawson, B R; de Almeida, R M; De Domenico, M; De Donato, C; de Jong, S J; De La Vega, G; Junior, W J M de Mello; Neto, J R T de Mello; De Mitri, I; de Souza, V; de Vries, K D; Decerprit, G; del Peral, L; Deligny, O; Dembinski, H; Denkiewicz, A; Di Giulio, C; Diaz, J C; Castro, M L Díaz; Diep, P N; Dobrigkeit, C; D'Olivo, J C; Dong, P N; Dorofeev, A; Anjos, J C dos; Dova, M T; D'Urso, D; Dutan, I; Ebr, J; Engel, R; Erdmann, M; Escobar, C O; Etchegoyen, A; Luis, P Facal San; Falcke, H; Farrar, G; Fauth, A C; Fazzini, N; Ferguson, A P; Ferrero, A; Fick, B; Filevich, A; Filipčič, A; Fliescher, S; Fracchiolla, C E; Fraenkel, E D; Fröhlich, U; Fuchs, B; Gamarra, R F; Gambetta, S; García, B; Gámez, D García; Garcia-Pinto, D; Gascon, A; Gemmeke, H; Gesterling, K; Ghia, P L; Giaccari, U; Giller, M; Glass, H; Gold, M S; Golup, G; Albarracin, F Gomez; Berisso, M Gómez; Gonçalves, P; Gonzalez, D; Gonzalez, J G; Gookin, B; Góra, D; Gorgi, A; Gouffon, P; Gozzini, S R; Grashorn, E; Grebe, S; Griffith, N; Grigat, M; Grillo, A F; Guardincerri, Y; Guarino, F; Guedes, G P; Hague, J D; Hansen, P; Harari, D; Harmsma, S; Harton, J L; Haungs, A; Hebbeker, T; Heck, D; Herve, A E; Hojvat, C; Holmes, V C; Homola, P; Hörandel, J R; Horneffer, A; Hrabovský, M; Huege, T; Insolia, A; Ionita, F; Italiano, A; Jiraskova, S; Kadija, K; Kampert, K H; Karhan, P; Karova, T; Kasper, P; Kégl, B; Keilhauer, B; Keivani, A; Kelley, J L; Kemp, E; Kieckhafer, R M; Klages, H O; Kleifges, M; Kleinfeller, J; Knapp, J; Koang, D -H; Kotera, K; Krohm, N; Krömer, O; Kruppke-Hansen, D; Kuehn, F; Kuempel, D; Kulbartz, J K; Kunka, N; La Rosa, G; Lachaud, C; Lautridou, P; Leão, M S A B; Lebrun, D; Lebrun, P; de Oliveira, M A Leigui; Lemiere, A; Letessier-Selvon, A; Lhenry-Yvon, I; Link, K; López, R; Agüera, A Lopez; Louedec, K; Bahilo, J Lozano; Lucero, A; Ludwig, M; Lyberis, H; Macolino, C; Maldera, S; Mandat, D; Mantsch, P; Mariazzi, A G; Marin, V; Maris, I C; Falcon, H R Marquez; Marsella, G; Martello, D; Martin, L; Bravo, O Martínez; Mathes, H J; Matthews, J; Matthews, J A J; Matthiae, G; Maurizio, D; Mazur, P O; Medina-Tanco, G; Melissas, M; Melo, D; Menichetti, E; Menshikov, A; Mertsch, P; Meurer, C; Mičanović, S; Micheletti, M I; Miller, W; Miramonti, L; Mollerach, S; Monasor, M; Ragaigne, D Monnier; Montanet, F; Morales, B; Morello, C; Moreno, E; Moreno, J C; Morris, C; Mostafá, M; Moura., C A; Mueller, S; Muller, M A; Müller, G; Münchmeyer, M; Mussa, R; Navarra, G; Navarro, J L; Navas, S; Necesal, P; Nellen, L; Nelles, A; Nhung, P T; Nierstenhoefer, N; Nitz, D; Nosek, D; Nožka, L; Nyklicek, M; Oehlschläger, J; Olinto, A; Oliva, P; Olmos-Gilbaja, V M; Ortiz, M; Pacheco, N; Selmi-Dei, D Pakk; Palatka, M; Pallotta, J; Palmieri, N; Parente, G; Parizot, E; Parra, A; Parrisius, J; Parsons, R D; Pastor, S; Paul, T; Pech, M; Pȩkala, J; Pelayo, R; Pepe, I M; Perrone, L; Pesce, R; Petermann, E; Petrera, S; Petrinca, P; Petrolini, A; Petrov, Y; Petrovic, J; Pfendner, C; Phan, N; Piegaia, R; Pierog, T; Pieroni, P; Pimenta, M; Pirronello, V; Platino, M; Ponce, V H; Pontz, M; Privitera, P; Prouza, M; Quel, E J; Rautenberg, J; Ravel, O; Ravignani, D; Revenu, B; Ridky, J; Risse, M; Ristori, P; Rivera, H; Rivière, C; Rizi, V; Robledo, C; de Carvalho, W Rodrigues; Rodriguez, G; Martino, J Rodriguez; Rojo, J Rodriguez; Rodriguez-Cabo, I; Rodríguez-Frías, M D; Ros, G; Rosado, J; Rossler, T; Roth, M; Rouillé-d'Orfeuil, B; Roulet, E; Rovero, A C; Rühle, C; Salamida, F; Salazar, H; Salina, G; Sánchez, F; Santander, M; Santo, C E; Santos, E; Santos, E M; Sarazin, F; Sarkar, S; Sato, R; Scharf, N; Scherini, V; Schieler, H; Schiffer, P; Schmidt, A; Schmidt, F; Schmidt, T; Scholten, O; Schoorlemmer, H; Schovancova, J; Schovánek, P; Schroeder, F; Schulte, S; Schuster, D; Sciutto, S J; Scuderi, M; Segreto, A; Semikoz, D; Settimo, M; Shadkam, A; Shellard, R C; Sidelnik, I; Sigl, G; Śmiałkowski, A; Šmída, R; Snow, G R; Sommers, P; Sorokin, J; Spinka, H; Squartini, R; Stapleton, J; Stasielak, J; Stephan, M; Stutz, A; Suarez, F; Suomijärvi, T; Supanitsky, A D; Šuša, T; Sutherland, M S; Swain, J; Szadkowski, Z; Szuba, M; Tamashiro, A; Tapia, A; Taşcău, O; Tcaciuc, R; Tegolo, D; Thao, N T; Thomas, D; Tiffenberg, J; Timmermans, C; Tiwari, D K; Tkaczyk, W; Peixoto, C J Todero; Tomé, B; Tonachini, A; Travnicek, P; Tridapalli, D B; Tristram, G; Trovato, E; Tueros, M; Ulrich, R; Unger, M; Urban, M; Galicia, J F Valdés; Valiño, I; Valore, L; Berg, A M van den; Cárdenas, B Vargas; Vázquez, J R; Vázquez, R A; Veberič, D; Verzi, V; Videla, M; Villaseñor, L; Wahlberg, H; Wahrlich, P; Wainberg, O; Warner, D; Watson, A A; Weber, M; Weidenhaupt, K; Weindl, A; Westerhoff, S; Whelan, B J; Wieczorek, G; Wiencke, L; Wilczyńska, B; Wilczyński, H; Will, M; Williams, C; Winchen, T; Winders, L; Winnick, M G; Wommer, M; Wundheiler, B; Yamamoto, T; Younk, P; Yuan, G; Zamorano, B; Zas, E; Zavrtanik, D; Zavrtanik, M; Zaw, I; Zepeda, A; Ziolkowski, M; 10.1016/j.nima.2011.01.049

    2011-01-01

    The advent of the Auger Engineering Radio Array (AERA) necessitates the development of a powerful framework for the analysis of radio measurements of cosmic ray air showers. As AERA performs "radio-hybrid" measurements of air shower radio emission in coincidence with the surface particle detectors and fluorescence telescopes of the Pierre Auger Observatory, the radio analysis functionality had to be incorporated in the existing hybrid analysis solutions for fluoresence and surface detector data. This goal has been achieved in a natural way by extending the existing Auger Offline software framework with radio functionality. In this article, we lay out the design, highlights and features of the radio extension implemented in the Auger Offline framework. Its functionality has achieved a high degree of sophistication and offers advanced features such as vectorial reconstruction of the electric field, advanced signal processing algorithms, a transparent and efficient handling of FFTs, a very detailed simulation of...

  13. A Conceptual Framework of Human Reliability Analysis for Execution Human Error in NPP Advanced MCRs

    Energy Technology Data Exchange (ETDEWEB)

    Jang, In Seok; Kim, Ar Ryum; Seong, Poong Hyun [KAIST, Daejeon (Korea, Republic of); Jung, Won Dea [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-08-15

    The operation environment of Main Control Rooms (MCRs) in Nuclear Power Plants (NPPs) has changed with the adoption of new human-system interfaces that are based on computer-based technologies. The MCRs that include these digital and computer technologies, such as large display panels, computerized procedures, and soft controls, are called Advanced MCRs. Among the many features of Advanced MCRs, soft controls are a particularly important feature because the operation action in NPP Advanced MCRs is performed by soft control. Using soft controls such as mouse control, and touch screens, operators can select a specific screen, then choose the controller, and finally manipulate the given devices. Due to the different interfaces between soft control and hardwired conventional type control, different human error probabilities and a new Human Reliability Analysis (HRA) framework should be considered in the HRA for advanced MCRs. In other words, new human error modes should be considered for interface management tasks such as navigation tasks, and icon (device) selection tasks in monitors and a new framework of HRA method taking these newly generated human error modes into account should be considered. In this paper, a conceptual framework for a HRA method for the evaluation of soft control execution human error in advanced MCRs is suggested by analyzing soft control tasks.

  14. Windows registry forensics advanced digital forensic analysis of the Windows registry

    CERN Document Server

    Carvey, Harlan

    2011-01-01

    Harlan Carvey brings readers an advanced book on Windows Registry - the most difficult part of Windows to analyze in forensics! Windows Registry Forensics provides the background of the Registry to help develop an understanding of the binary structure of Registry hive files. Approaches to live response and analysis are included, and tools and techniques for postmortem analysis are discussed at length. Tools and techniques will be presented that take the analyst beyond the current use of viewers and into real analysis of data contained in the Registry. This book also has a DVD containing tools, instructions and videos.

  15. Analysis of the Tunnel Boring Machine Advancement on the Bologna-Florence Railway Link

    Directory of Open Access Journals (Sweden)

    M. Cardu

    2009-01-01

    Full Text Available Problem statement: The high-velocity railway link between Bologna and Firenze (Italy is today under construction and several tunnels have to be excavated for this purpose, some of these using TBMs. A small diameter tunnel, named Cunicolo ginori, was realized by TBM parallel to a large railway tunnel (Vaglia, at the distance of only 35 m. Approach: The Vaglia tunnel had been excavated by conventional methods and provided, thanks to a detailed survey and a systematic geotechnical monitoring (rock quality evaluation and convergence measurements the characterization data of the crossed rock mass; moreover the TBM performance data in Cunicolo ginori were continuously monitored. A tunnel stretch, 587 m long, was recorded and the analysis of the data from both surveys allowed to correlate the geomechanical parameters of the rock-mass to the TBM performances (net advancement rate, thrust, specific energy. Results: Based on this large amount of data a new system to predict the net TBM advancement rate for a tunnel in rock masses of known geological and geomechanical characteristics was then developed. Also the Utilization Coefficient (CU can be correlated to the rock quality Indices: The net advance rate and the utilization coefficient provide a mean to foresee the gross advancement rate and to evaluate the suitability of a machine for the excavation of a tunnel. Conclusion: In this study, an analysis had been carried out on about 587 m of a service tunnel, excavated by a TBM in a flysch formation.

  16. Statin as a Combined Therapy for Advanced-Stage Ovarian Cancer: A Propensity Score Matched Analysis

    Directory of Open Access Journals (Sweden)

    Hong-Yu Chen

    2016-01-01

    Full Text Available Background. Despite the great achievements in the treatment of advanced-stage ovarian cancer, it is still a severe condition with an unfavorable 5-year survival rate. Statins have been suggested to reduce the risk of several cancers beyond their cholesterol-lowing effects. However, the prognostic significance of statins in patients with advanced-stage ovarian cancer remains controversial. Methods. A retrospective study was performed to evaluate the association between statin intake and overall survival (OS among patients with advanced-stage ovarian cancer. Patients who underwent cytoreductive surgery followed by courses of intravenous chemotherapy were matched through a propensity score analysis. Results. A total of 60 propensity-matched patients were included. Women in statin group showed a similar OS than the nonstatin counterparts (P=0.966, whereas residual tumor was significantly associated with better OS (P=0.013 and was an independent factor that associated with OS (P=0.002, hazard ratio = 5.460, and 95% confidence interval: 1.894 to 15.742 in multivariable analysis. Conclusions. Our results suggested that statin usage was not associated with improved OS in patients with advanced-stage ovarian cancer undergoing surgery and chemotherapy. Considering the retrospective nature and the relative small sample size of the study, further prospective studies and random control trials are needed.

  17. Latest climate changes in Romania :tornadoes

    Science.gov (United States)

    Pop, Elena

    2014-05-01

    Latest climate changes in Romania :tornadoes As climate change has been considered a research priority in the European Strategy for enduring development , I have done a detailed research with my students of the new climate change that has been going on in Romania for the past decade. More precisely I have studied together with my students the phenomenon of tornadoes that have seriously affected on some occasions some our our country's locations, such as Facaeni, in the county of Ialomita, in August 2002. A quite unusual phenomenon occurred on that location situated at 44.56 degrees northern latitude and at 27.89 degrees eastern longitude, that caused severe damage to the local environment and three persons lost their lives in the process, as well as other thirty people suffering from bad injuries. The magnitude of that strong phenomenon rose on the Fujita scale at level F3 which implied wing gusts between 252-300 km/ hour . A main cause of occurrence of such a severe weather was the difference in temperature of two huge air masses, one of Polar origin, and other coming from tropical latitudes . Their crossroads was on that precise territory of Romania. The duration of the worst part of the tornado path lasted only for two minutes, but the consequences of its passage were colossal : total destruction of 33 households, and other 395 were partially damaged, 1,000 people afflicted by the devastation and 100 acres of acacia tree forest ripped off the ground. The first ever recorded tornado phenomenon in Romania was around 1894-1896, considered at that time " a freak of nature" was seen as a cloud formation abnormality , an uncontrolled force of nature that had a huge impact , and at the same time, it vanished into "thin air " fast. The most affected areas in Romania by tornadoes are the south-eastern planes where the cloud formations can create fast columns of air rotating up to 500 km/hour. The local people compared the cloud funnels created on the planes to "serpents

  18. Methods and advances in metabolic flux analysis: a mini-review.

    Science.gov (United States)

    Antoniewicz, Maciek R

    2015-03-01

    Metabolic flux analysis (MFA) is one of the pillars of metabolic engineering. Over the past three decades, it has been widely used to quantify intracellular metabolic fluxes in both native (wild type) and engineered biological systems. Through MFA, changes in metabolic pathway fluxes are quantified that result from genetic and/or environmental interventions. This information, in turn, provides insights into the regulation of metabolic pathways and may suggest new targets for further metabolic engineering of the strains. In this mini-review, we discuss and classify the various methods of MFA that have been developed, which include stoichiometric MFA, (13)C metabolic flux analysis, isotopic non-stationary (13)C metabolic flux analysis, dynamic metabolic flux analysis, and (13)C dynamic metabolic flux analysis. For each method, we discuss key advantages and limitations and conclude by highlighting important recent advances in flux analysis approaches.

  19. Immunoassay Methods and their Applications in Pharmaceutical Analysis: Basic Methodology and Recent Advances.

    Science.gov (United States)

    Darwish, Ibrahim A

    2006-09-01

    Immunoassays are bioanalytical methods in which the quantitation of the analyte depends on the reaction of an antigen (analyte) and an antibody. Immunoassays have been widely used in many important areas of pharmaceutical analysis such as diagnosis of diseases, therapeutic drug monitoring, clinical pharmacokinetic and bioequivalence studies in drug discovery and pharmaceutical industries. The importance and widespread of immunoassay methods in pharmaceutical analysis are attributed to their inherent specificity, high-throughput, and high sensitivity for the analysis of wide range of analytes in biological samples. Recently, marked improvements were achieved in the field of immunoassay development for the purposes of pharmaceutical analysis. These improvements involved the preparation of the unique immunoanalytical reagents, analysis of new categories of compounds, methodology, and instrumentation. The basic methodologies and recent advances in immunoassay methods applied in different fields of pharmaceutical analysis have been reviewed.

  20. International Conference on Recent Advances in Mathematical Biology, Analysis and Applications

    CERN Document Server

    Saleem, M; Srivastava, H; Khan, Mumtaz; Merajuddin, M

    2016-01-01

    The book contains recent developments and contemporary research in mathematical analysis and in its application to problems arising from the biological and physical sciences. The book is of interest to readers who wish to learn of new research in such topics as linear and nonlinear analysis, mathematical biology and ecology, dynamical systems, graph theory, variational analysis and inequalities, functional analysis, differential and difference equations, partial differential equations, approximation theory, and chaos. All papers were prepared by participants at the International Conference on Recent Advances in Mathematical Biology, Analysis and Applications (ICMBAA-2015) held during 4–6 June 2015 in Aligarh, India. A focal theme of the conference was the application of mathematics to the biological sciences and on current research in areas of theoretical mathematical analysis that can be used as sophisticated tools for the study of scientific problems. The conference provided researchers, academicians and ...

  1. Low-latency analysis pipeline for compact binary coalescences in the advanced gravitational wave detector era

    CERN Document Server

    Adams, T; Germain, V; Guidi, G M; Marion, F; Montani, M; Mours, B; Piergiovanni, F; Wang, G

    2015-01-01

    The Multi-Band Template Analysis (MBTA) pipeline is a low-latency coincident analysis pipeline for the detection of gravitational waves (GWs) from compact binary coalescences (CBCs). MBTA runs with a low computational cost, and can identify candidate GW events online with a sub-minute latency. The low computational running cost of MBTA also makes it useful for data quality studies. Events detected by MBTA online can be used to alert astronomical partners for electromagnetic (EM) follow-up. We outline the current status of MBTA and give details of recent pipeline upgrades and validation tests that were performed in preparation for the first advanced detector observing period. The MBTA pipeline is ready for the outset of the advanced detector era and the exciting prospects it will bring.

  2. Low-latency analysis pipeline for compact binary coalescences in the advanced gravitational wave detector era

    Science.gov (United States)

    Adams, T.; Buskulic, D.; Germain, V.; Guidi, G. M.; Marion, F.; Montani, M.; Mours, B.; Piergiovanni, F.; Wang, G.

    2016-09-01

    The multi-band template analysis (MBTA) pipeline is a low-latency coincident analysis pipeline for the detection of gravitational waves (GWs) from compact binary coalescences. MBTA runs with a low computational cost, and can identify candidate GW events online with a sub-minute latency. The low computational running cost of MBTA also makes it useful for data quality studies. Events detected by MBTA online can be used to alert astronomical partners for electromagnetic follow-up. We outline the current status of MBTA and give details of recent pipeline upgrades and validation tests that were performed in preparation for the first advanced detector observing period. The MBTA pipeline is ready for the outset of the advanced detector era and the exciting prospects it will bring.

  3. 'Eraser Challenge' Latest Harmful Social Media Trend for Kids

    Science.gov (United States)

    Skip navigation U.S. National Library of Medicine Menu ... Latest Harmful Social Media Trend for Kids Burns, abrasions the result as youngsters 'erase' their skin away To use the sharing features on ...

  4. Latest Sickle Cell Research | NIH MedlinePlus the Magazine

    Science.gov (United States)

    ... this page please turn Javascript on. Special Section: Sickle Cell Disease Latest Sickle Cell Research Past Issues / Winter 2011 Table of Contents ... Complications of sickle cell trait 100 Years of Sickle Cell Research Dr. James B. Herrick Photo: National Library ...

  5. Latest Zika Puzzle: How U.S. Patient Infected Caregiver

    Science.gov (United States)

    ... https://medlineplus.gov/news/fullstory_159925.html Latest Zika Puzzle: How U.S. Patient Infected Caregiver Officials say ... MONDAY, July 18, 2016 (HealthDay News) -- The mysterious Zika virus continues to surprise health scientists. On Monday, ...

  6. Design and Transient Analysis of Passive Safety Cooling Systems for Advanced Nuclear Reactors

    OpenAIRE

    Galvez, Cristhian

    2011-01-01

    The Pebble Bed Advanced High Temperature Reactor (PB-AHTR) is a pebble fueled, liquid salt cooled, high temperature nuclear reactor design that can be used for electricity generation or other applications requiring the availability of heat at elevated temperatures. A stage in the design evolution of this plant requires the analysis of the plant during a variety of potential transients to understand the primary and safety cooling system response. This study focuses on the performance of the pa...

  7. Final Technical Report: Advanced Measurement and Analysis of PV Derate Factors.

    Energy Technology Data Exchange (ETDEWEB)

    King, Bruce Hardison [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Burton, Patrick D. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hansen, Clifford [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Jones, Christian Birk [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-12-01

    The Advanced Measurement and Analysis of PV Derate Factors project focuses on improving the accuracy and reducing the uncertainty of PV performance model predictions by addressing a common element of all PV performance models referred to as “derates”. Widespread use of “rules of thumb”, combined with significant uncertainty regarding appropriate values for these factors contribute to uncertainty in projected energy production.

  8. Statistics and Analysis on Papers Published on Journal 'Advanced Technology of Electrical Engineering and Energy'

    Institute of Scientific and Technical Information of China (English)

    QIN Jie; LIN Liangzhen; QI Zhiping; MA Yuhuan; SHEN Guoliao; JING Bohong

    2009-01-01

    The paper presented the statistics and analysis on papers published on the journal 'Advanced Technology of Electrical Engineering and Energy' from 1996 to 2008: the paper acceptance rate, the paper category, the first author's affiliations, the top 7 first authors, the top 10 coauthors and also the joumal evaluation indexes of the journal. It offers details of the journal to anyone interested, especially to our editorial board and our broad readers.

  9. Implementation and Initial Testing of Advanced Processing and Analysis Algorithms for Correlated Neutron Counting

    Energy Technology Data Exchange (ETDEWEB)

    Santi, Peter Angelo [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Cutler, Theresa Elizabeth [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Favalli, Andrea [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Koehler, Katrina Elizabeth [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Henzl, Vladimir [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Henzlova, Daniela [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Parker, Robert Francis [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Croft, Stephen [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-12-01

    In order to improve the accuracy and capabilities of neutron multiplicity counting, additional quantifiable information is needed in order to address the assumptions that are present in the point model. Extracting and utilizing higher order moments (Quads and Pents) from the neutron pulse train represents the most direct way of extracting additional information from the measurement data to allow for an improved determination of the physical properties of the item of interest. The extraction of higher order moments from a neutron pulse train required the development of advanced dead time correction algorithms which could correct for dead time effects in all of the measurement moments in a self-consistent manner. In addition, advanced analysis algorithms have been developed to address specific assumptions that are made within the current analysis model, namely that all neutrons are created at a single point within the item of interest, and that all neutrons that are produced within an item are created with the same energy distribution. This report will discuss the current status of implementation and initial testing of the advanced dead time correction and analysis algorithms that have been developed in an attempt to utilize higher order moments to improve the capabilities of correlated neutron measurement techniques.

  10. Lineage analysis of early and advanced tubular adenocarcinomas of the stomach: continuous or discontinuous?

    Directory of Open Access Journals (Sweden)

    Mukaisho Ken-ichi

    2010-06-01

    Full Text Available Abstract Background Eradication of early gastric carcinoma (GC is thought to contribute to reduction in the mortality of GC, given that most of the early GCs progress to the advanced GCs. However, early GC is alternatively considered a dormant variant of GC, and it infrequently progresses to advanced GC. The aim of this study was to clarify the extent of overlap of genetic lineages between early and advanced tubular adenocarcinomas (TUBs of the stomach. Methods Immunohistochemical staining for p53 was performed using 28 surgically resected stomachs with 13 intramucosal and 15 invasive TUBs. By chromosome- and array-based comparative genomic hybridization (CGH, genomic copy number constitution was compared between the mucosal and invasive parts of the invasive TUBs and between the mucosal parts of the invasive and intramucosal TUBs, using 25 and 22 TUBs, respectively. TP53 mutation in exons 5-8 was examined in 20 TUBs. Results Chromosomal CGH revealed that 4q+ and 11q+ were more common in advanced and early TUBs, respectively, whereas copy number changes in 8q and 17p showed no significant differences between early and advanced TUBs. However, array CGH revealed that, of the 13 intramucosal TUBs examined, loss of MYC (MYC- and gain of TP53 (TP53+ was detected in 9 TUBs and MYC+ and/or TP53- was detected in 3 TUBs. Of the mucosal samples of 9 invasive TUBs, 7 showed MYC-/TP53+ and none showed MYC+ and/or TP53-. Of the 9 samples from the invasive parts, 1 (from submucosal cancers showed MYC-/TP53+ and 6 (1 from submucosal and 5 from advanced cancers showed MYC+ and/or TP53-. The latter 6 tumours commonly showed a mutant pattern (diffuse or null in p53 immunohistochemistry, and 4 of the 6 tumours assessable for TP53 sequence analysis revealed mutations. The overall array CGH pattern indicated that, between the mucosal and invasive parts, genetic lineage was found discontinuous in 5 advanced cancers and continuous in 3 submucosal cancers. Conclusions

  11. Advanced electric drives analysis, control, and modeling using MATLAB/Simulink

    CERN Document Server

    Mohan, Ned

    2014-01-01

    Advanced Electric Drives utilizes a physics-based approach to explain the fundamental concepts of modern electric drive control and its operation under dynamic conditions. Gives readers a "physical" picture of electric machines and drives without resorting to mathematical transformations for easy visualization Confirms the physics-based analysis of electric drives mathematically Provides readers with an analysis of electric machines in a way that can be easily interfaced to common power electronic converters and controlled using any control scheme Makes the MATLAB/Simulink files used in exampl

  12. Advances in research methods for information systems research data mining, data envelopment analysis, value focused thinking

    CERN Document Server

    Osei-Bryson, Kweku-Muata

    2013-01-01

    Advances in social science research methodologies and data analytic methods are changing the way research in information systems is conducted. New developments in statistical software technologies for data mining (DM) such as regression splines or decision tree induction can be used to assist researchers in systematic post-positivist theory testing and development. Established management science techniques like data envelopment analysis (DEA), and value focused thinking (VFT) can be used in combination with traditional statistical analysis and data mining techniques to more effectively explore

  13. Advance of CE and CEC in phytochemical analysis (2012–2013).

    Science.gov (United States)

    Zhao, Jing; Hu, De-jun; Lao, Kameng; Yang, Zong-mei; Li, Shao-ping

    2014-01-01

    This article presents an overview of the advance of CE and CEC in phytochemical analysis, based on the literature not mentioned in our previous review papers [Chen, X. J., Zhao, J., Wang, Y. T., Huang, L. Q., Li, S. P., Electrophoresis 2012, 33, 168–179], mainly covering the years 2012–2013. In this article, attention is paid to online preconcentration, rapid separation, and sensitive detection. Selected examples illustrate the applicability of CE and CEC in biomedical, pharmaceutical, environmental, and food analysis. Finally, some general conclusions and future perspectives are given.

  14. Advancing alternatives analysis: The role of predictive toxicology in selecting safer chemical products and processes.

    Science.gov (United States)

    Malloy, Timothy; Zaunbrecher, Virginia; Beryt, Elizabeth; Judson, Richard; Tice, Raymond; Allard, Patrick; Blake, Ann; Cote, Ila; Godwin, Hilary; Heine, Lauren; Kerzic, Patrick; Kostal, Jakub; Marchant, Gary; McPartland, Jennifer; Moran, Kelly; Nel, Andre; Oguseitan, Oladele; Rossi, Mark; Thayer, Kristina; Tickner, Joel; Whittaker, Margaret; Zarker, Ken

    2017-03-01

    Alternatives analysis (AA) is a method used in regulation and product design to identify, assess, and evaluate the safety and viability of potential substitutes for hazardous chemicals. It requires toxicological data for the existing chemical and potential alternatives. Predictive toxicology uses in silico and in vitro approaches, computational models, and other tools to expedite toxicological data generation in more cost-effective manner than traditional approaches. This article briefly reviews the challenges associated with using predictive toxicology in regulatory AA, then presents four recommendations for its advancement. It recommends using case studies to advance the integration of predictive toxicology into AA; adopting a stepwise process to employing predicative toxicology in AA beginning with prioritization of chemicals of concern; leveraging existing resources to advance the integration of predictive toxicology into the practice of AA, and supporting trans-disciplinary efforts. The further incorporation of predictive toxicology into AA would advance the ability of companies and regulators to select alternatives to harmful ingredients, and potentially increase the use of predictive toxicology in regulation more broadly. This article is protected by copyright. All rights reserved.

  15. Latest results from the KASCADE-Grande experiment

    Energy Technology Data Exchange (ETDEWEB)

    Chiavassa, A., E-mail: achiavas@to.infn.it [Dipartimento di Fisica, Università degli Studi di Torino (Italy); Apel, W.D. [Institut für Kernphysik, KIT - Karlsruher Institut für Technologie (Germany); Arteaga-Velázquez, J.C. [Universidad Michoacana, Instituto de Física y Matemáticas, Morelia (Mexico); Bekk, K. [Institut für Kernphysik, KIT - Karlsruher Institut für Technologie (Germany); Bertaina, M. [Dipartimento di Fisica, Università degli Studi di Torino (Italy); Blümer, J. [Institut für Kernphysik, KIT - Karlsruher Institut für Technologie (Germany); Institut für Experimentelle Kernphysik, KIT - Karlsruher Institut für Technologie (Germany); Bozdog, H. [Institut für Kernphysik, KIT - Karlsruher Institut für Technologie (Germany); Brancus, I.M. [National Institute of Physics and Nuclear Engineering, Bucharest (Romania); Cantoni, E. [Dipartimento di Fisica, Università degli Studi di Torino (Italy); Osservatorio Astrofisico di Torino, INAF Torino (Italy); Cossavella, F. [Institut für Experimentelle Kernphysik, KIT - Karlsruher Institut für Technologie (Germany); Curcio, C. [Dipartimento di Fisica, Università degli Studi di Torino (Italy); Daumiller, K. [Institut für Kernphysik, KIT - Karlsruher Institut für Technologie (Germany); and others

    2014-04-01

    The KASCADE-Grande experiment operated at KIT from January 2004 to November 2012, measuring EAS generated by primary cosmic rays in the 10{sup 16}–10{sup 18} eV energy range. The experiment detected, for each single event, with a high resolution, the total number of charged particles (N{sub ch}) and of muons (N{sub μ}). In this contribution we present the latest results about: (i)The measurement of the all particle energy spectrum, discussing the influence of the hadronic interaction model used to derive the energy calibration of the experimental data. (ii)The energy spectra derived separating the events according to the N{sub μ}/N{sub ch} ratio. This technique allowed us to unveil a steepening of the spectrum of heavy primaries at E∼10{sup 16.92±0.04}eV and a hardening of the spectrum of light primaries at E∼10{sup 17.08±0.08}eV. (iii)The elemental spectra (for five mass groups) obtained applying a detailed unfolding analysis technique. (iv)A search for large scale anisotropies.

  16. Latest results on neutrino oscillation from the NOMAD experiment

    CERN Document Server

    Roda, C

    2001-01-01

    The latest results on nu /sub tau / appearance search in nu /sub mu / to nu /sub tau / and nu /sub e/ to nu /sub tau / oscillation in NOMAD are reported. The analysis, carried out on the full data sample, is based on kinematic criteria. No evidence of oscillations is found. In the two-family oscillation scenario this sets a limit on sin/sup 2/ 2 theta /sub mu tau / < 4.0 * 10/sup -4/ at large Delta m/sup 2/ and Delta m/sup 2/ < 0.7 eV/sup 2//c/sup 4/ for sin/sup 2/ 2 theta /sub mu tau / = 1 at 90% C.L.. If the results are interpreted in the nu /sub e / to nu /sub tau / oscillation hypothesis the corresponding limits are sin/sup 2/ 2 theta /sub e tau / < 2.0 * 10/sup -2/ at large Delta m /sup 2/ and Delta m/sup 2/ < 6 eV/sup 2//c/sup 4/ for sin/sup 2/ 2 theta /sub e tau / = 1 at 90% C.L.

  17. Single Particle ICP-MS: Advances toward routine analysis of nanomaterials.

    Science.gov (United States)

    Montaño, Manuel D; Olesik, John W; Barber, Angela G; Challis, Katie; Ranville, James F

    2016-07-01

    From its early beginnings in characterizing aerosol particles to its recent applications for investigating natural waters and waste streams, single particle inductively coupled plasma-mass spectrometry (spICP-MS) has proven to be a powerful technique for the detection and characterization of aqueous dispersions of metal-containing nanomaterials. Combining the high-throughput of an ensemble technique with the specificity of a single particle counting technique and the elemental specificity of ICP-MS, spICP-MS is capable of rapidly providing researchers with information pertaining to size, size distribution, particle number concentration, and major elemental composition with minimal sample perturbation. Recently, advances in data acquisition, signal processing, and the implementation of alternative mass analyzers (e.g., time-of-flight) has resulted in a wider breadth of particle analyses and made significant progress toward overcoming many of the challenges in the quantitative analysis of nanoparticles. This review provides an overview of spICP-MS development from a niche technique to application for routine analysis, a discussion of the key issues for quantitative analysis, and examples of its further advancement for analysis of increasingly complex environmental and biological samples. Graphical Abstract Single particle ICP-MS workflow for the analysis of suspended nanoparticles.

  18. Work Domain Analysis Methodology for Development of Operational Concepts for Advanced Reactors

    Energy Technology Data Exchange (ETDEWEB)

    Hugo, Jacques [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-05-01

    This report describes a methodology to conduct a Work Domain Analysis in preparation for the development of operational concepts for new plants. This method has been adapted from the classical method described in the literature in order to better deal with the uncertainty and incomplete information typical of first-of-a-kind designs. The report outlines the strategy for undertaking a Work Domain Analysis of a new nuclear power plant and the methods to be used in the development of the various phases of the analysis. Basic principles are described to the extent necessary to explain why and how the classical method was adapted to make it suitable as a tool for the preparation of operational concepts for a new nuclear power plant. Practical examples are provided of the systematic application of the method and the various presentation formats in the operational analysis of advanced reactors.

  19. Cost/benefit analysis of advanced materials technology candidates for the 1980's, part 2

    Science.gov (United States)

    Dennis, R. E.; Maertins, H. F.

    1980-01-01

    Cost/benefit analyses to evaluate advanced material technologies projects considered for general aviation and turboprop commuter aircraft through estimated life-cycle costs, direct operating costs, and development costs are discussed. Specifically addressed is the selection of technologies to be evaluated; development of property goals; assessment of candidate technologies on typical engines and aircraft; sensitivity analysis of the changes in property goals on performance and economics, cost, and risk analysis for each technology; and ranking of each technology by relative value. The cost/benefit analysis was applied to a domestic, nonrevenue producing, business-type jet aircraft configured with two TFE731-3 turbofan engines, and to a domestic, nonrevenue producing, business type turboprop aircraft configured with two TPE331-10 turboprop engines. In addition, a cost/benefit analysis was applied to a commercial turboprop aircraft configured with a growth version of the TPE331-10.

  20. The Advanced Modeling, Simulation and Analysis Capability Roadmap Vision for Engineering

    Science.gov (United States)

    Zang, Thomas; Lieber, Mike; Norton, Charles; Fucik, Karen

    2006-01-01

    This paper summarizes a subset of the Advanced Modeling Simulation and Analysis (AMSA) Capability Roadmap that was developed for NASA in 2005. The AMSA Capability Roadmap Team was chartered to "To identify what is needed to enhance NASA's capabilities to produce leading-edge exploration and science missions by improving engineering system development, operations, and science understanding through broad application of advanced modeling, simulation and analysis techniques." The AMSA roadmap stressed the need for integration, not just within the science, engineering and operations domains themselves, but also across these domains. Here we discuss the roadmap element pertaining to integration within the engineering domain, with a particular focus on implications for future observatory missions. The AMSA products supporting the system engineering function are mission information, bounds on information quality, and system validation guidance. The Engineering roadmap element contains 5 sub-elements: (1) Large-Scale Systems Models, (2) Anomalous Behavior Models, (3) advanced Uncertainty Models, (4) Virtual Testing Models, and (5) space-based Robotics Manufacture and Servicing Models.

  1. Advancing biopharmaceutical process development by system-level data analysis and integration of omics data.

    Science.gov (United States)

    Schaub, Jochen; Clemens, Christoph; Kaufmann, Hitto; Schulz, Torsten W

    2012-01-01

    Development of efficient bioprocesses is essential for cost-effective manufacturing of recombinant therapeutic proteins. To achieve further process improvement and process rationalization comprehensive data analysis of both process data and phenotypic cell-level data is essential. Here, we present a framework for advanced bioprocess data analysis consisting of multivariate data analysis (MVDA), metabolic flux analysis (MFA), and pathway analysis for mapping of large-scale gene expression data sets. This data analysis platform was applied in a process development project with an IgG-producing Chinese hamster ovary (CHO) cell line in which the maximal product titer could be increased from about 5 to 8 g/L.Principal component analysis (PCA), k-means clustering, and partial least-squares (PLS) models were applied to analyze the macroscopic bioprocess data. MFA and gene expression analysis revealed intracellular information on the characteristics of high-performance cell cultivations. By MVDA, for example, correlations between several essential amino acids and the product concentration were observed. Also, a grouping into rather cell specific productivity-driven and process control-driven processes could be unraveled. By MFA, phenotypic characteristics in glycolysis, glutaminolysis, pentose phosphate pathway, citrate cycle, coupling of amino acid metabolism to citrate cycle, and in the energy yield could be identified. By gene expression analysis 247 deregulated metabolic genes were identified which are involved, inter alia, in amino acid metabolism, transport, and protein synthesis.

  2. Using Micro-Synchrophasor Data for Advanced Distribution Grid Planning and Operations Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Stewart, Emma [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Kiliccote, Sila [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); McParland, Charles [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Roberts, Ciaran [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2014-07-01

    This report reviews the potential for distribution-grid phase-angle data that will be available from new micro-synchrophasors (µPMUs) to be utilized in existing distribution-grid planning and operations analysis. This data could augment the current diagnostic capabilities of grid analysis software, used in both planning and operations for applications such as fault location, and provide data for more accurate modeling of the distribution system. µPMUs are new distribution-grid sensors that will advance measurement and diagnostic capabilities and provide improved visibility of the distribution grid, enabling analysis of the grid’s increasingly complex loads that include features such as large volumes of distributed generation. Large volumes of DG leads to concerns on continued reliable operation of the grid, due to changing power flow characteristics and active generation, with its own protection and control capabilities. Using µPMU data on change in voltage phase angle between two points in conjunction with new and existing distribution-grid planning and operational tools is expected to enable model validation, state estimation, fault location, and renewable resource/load characterization. Our findings include: data measurement is outstripping the processing capabilities of planning and operational tools; not every tool can visualize a voltage phase-angle measurement to the degree of accuracy measured by advanced sensors, and the degree of accuracy in measurement required for the distribution grid is not defined; solving methods cannot handle the high volumes of data generated by modern sensors, so new models and solving methods (such as graph trace analysis) are needed; standardization of sensor-data communications platforms in planning and applications tools would allow integration of different vendors’ sensors and advanced measurement devices. In addition, data from advanced sources such as µPMUs could be used to validate models to improve

  3. Left ventricular flow analysis: recent advances in numerical methods and applications in cardiac ultrasound.

    Science.gov (United States)

    Borazjani, Iman; Westerdale, John; McMahon, Eileen M; Rajaraman, Prathish K; Heys, Jeffrey J; Belohlavek, Marek

    2013-01-01

    The left ventricle (LV) pumps oxygenated blood from the lungs to the rest of the body through systemic circulation. The efficiency of such a pumping function is dependent on blood flow within the LV chamber. It is therefore crucial to accurately characterize LV hemodynamics. Improved understanding of LV hemodynamics is expected to provide important clinical diagnostic and prognostic information. We review the recent advances in numerical and experimental methods for characterizing LV flows and focus on analysis of intraventricular flow fields by echocardiographic particle image velocimetry (echo-PIV), due to its potential for broad and practical utility. Future research directions to advance patient-specific LV simulations include development of methods capable of resolving heart valves, higher temporal resolution, automated generation of three-dimensional (3D) geometry, and incorporating actual flow measurements into the numerical solution of the 3D cardiovascular fluid dynamics.

  4. Advanced Automation for Ion Trap Mass Spectrometry-New Opportunities for Real-Time Autonomous Analysis

    Science.gov (United States)

    Palmer, Peter T.; Wong, C. M.; Salmonson, J. D.; Yost, R. A.; Griffin, T. P.; Yates, N. A.; Lawless, James G. (Technical Monitor)

    1994-01-01

    The utility of MS/MS for both target compound analysis and the structure elucidation of unknowns has been described in a number of references. A broader acceptance of this technique has not yet been realized as it requires large, complex, and costly instrumentation which has not been competitive with more conventional techniques. Recent advancements in ion trap mass spectrometry promise to change this situation. Although the ion trap's small size, sensitivity, and ability to perform multiple stages of mass spectrometry have made it eminently suitable for on-line, real-time monitoring applications, advance automation techniques are required to make these capabilities more accessible to non-experts. Towards this end we have developed custom software for the design and implementation of MS/MS experiments. This software allows the user to take full advantage of the ion trap's versatility with respect to ionization techniques, scan proxies, and ion accumulation/ejection methods. Additionally, expert system software has been developed for autonomous target compound analysis. This software has been linked to ion trap control software and a commercial data system to bring all of the steps in the analysis cycle under control of the expert system. These software development efforts and their utilization for a number of trace analysis applications will be described.

  5. Development of Advanced Suite of Deterministic Codes for VHTR Physics Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Kang Seog; Cho, J. Y.; Lee, K. H. (and others)

    2007-07-15

    Advanced Suites of deterministic codes for VHTR physics analysis has been developed for detailed analysis of current and advanced reactor designs as part of a US-ROK collaborative I-NERI project. These code suites include the conventional 2-step procedure in which a few group constants are generated by a transport lattice calculation, and the reactor physics analysis is performed by a 3-dimensional diffusion calculation, and a whole core transport code that can model local heterogeneities directly at the core level. Particular modeling issues in physics analysis of the gas-cooled VHTRs were resolved, which include a double heterogeneity of the coated fuel particles, a neutron streaming in the coolant channels, a strong core-reflector interaction, and large spectrum shifts due to changes of the surrounding environment, temperature and burnup. And the geometry handling capability of the DeCART code were extended to deal with the hexagonal fuel elements of the VHTR core. The developed code suites were validated and verified by comparing the computational results with those of the Monte Carlo calculations for the benchmark problems.

  6. TIMSS Advanced 2015 and Advanced Placement Calculus & Physics. A Framework Analysis. Research in Review 2016-1

    Science.gov (United States)

    Lazzaro, Christopher; Jones, Lee; Webb, David C.; Grover, Ryan; Di Giacomo, F. Tony; Marino, Katherine Adele

    2016-01-01

    This report will determine to what degree the AP Physics 1 and 2 and AP Calculus AB and BC frameworks are aligned with the Trends in International Mathematics and Science Study (TIMSS) Advanced Physics and Mathematics frameworks. This will enable an exploration of any differences in content coverage and levels of complexity, and will set the stage…

  7. Research on Latest Development of Big Data and Big Data Analysis in China%当前我国大数据与数据分析发展的研究

    Institute of Scientific and Technical Information of China (English)

    徐达

    2015-01-01

    Big data is one of the most popular research directions at home and abroad. At present, in China, big data and big data analysis have moved out of the preliminary theoretical exploration stage, and formed a close industrial chain. The paper introduces what big data analytics achieved in business, public opinion analysis and medical field. Based on it, the paper summarizes challenges and opportunities of big data industry development in terms of the industrial chain, software and hardware conditions, professional workers, data resources, laws and regulations.%大数据是国内外最热门的研究方向之一.在大数据时代,人们身处的世界正在悄然改变.目前,我国大数据与数据分析已经走出了初步理论探索阶段,形成了初具规模的产业链.首先举例分析近年来我国大数据分析在商业、舆情分析和医疗领域的发展以及已取得的成就,在此基础上,总结了我国在大数据与数据分析行业,在产业链、软硬件条件、专业人才、数据资源和相关法律法规等方面所面临的挑战和机遇.

  8. Reproducibility of Digital PCR Assays for Circulating Tumor DNA Analysis in Advanced Breast Cancer

    Science.gov (United States)

    Hrebien, Sarah; O’Leary, Ben; Beaney, Matthew; Schiavon, Gaia; Fribbens, Charlotte; Bhambra, Amarjit; Johnson, Richard; Turner, Nicholas

    2016-01-01

    Circulating tumor DNA (ctDNA) analysis has the potential to allow non-invasive analysis of tumor mutations in advanced cancer. In this study we assessed the reproducibility of digital PCR (dPCR) assays of circulating tumor DNA in a cohort of patients with advanced breast cancer and assessed delayed plasma processing using cell free DNA preservative tubes. We recruited a cohort of 96 paired samples from 71 women with advanced breast cancer who had paired blood samples processed either immediately or delayed in preservative tubes with processing 48–72 hours after collection. Plasma DNA was analysed with multiplex digital PCR (mdPCR) assays for hotspot mutations in PIK3CA, ESR1 and ERBB2, and for AKT1 E17K. There was 94.8% (91/96) agreement in mutation calling between immediate and delayed processed tubes, kappa 0.88 95% CI 0.77–0.98). Discordance in mutation calling resulted from low allele frequency and likely stochastic effects. In concordant samples there was high correlation in mutant copies per ml plasma (r2 = 0.98; pprocessed tubes, although overall quantification of total cell free plasma DNA had similar prognostic effects in immediate (HR 3.6) and delayed (HR 3.0) tubes. There was moderate agreement in changes in allele fraction between sequential samples in quantitative mutation tracking (r = 0.84, p = 0.0002). Delayed processing of samples using preservative tubes allows for centralized ctDNA digital PCR mutation screening in advanced breast cancer. The potential of preservative tubes in quantitative mutation tracking requires further research. PMID:27760227

  9. Analysis of Prognostic Factors in 541 Female Patients with Advanced Non-small Cell Lung Cancer

    Directory of Open Access Journals (Sweden)

    Meina WU

    2011-03-01

    Full Text Available Background and objective As there is a sharp increase in the incidence of lung cancer in women in recent years, it has brought broad concerns with its unique clinical and epidemiological characteristics and better prognosis. The aim of this study is to analyze the clinical data of women with advanced non-small cell lung cancer (NSCLC retrospectively to explore the prognostic factors. Methods Clinical data of 541 female patients with advanced NSCLC were collected and followed up till death. The primary endpoint is overall survival (OS. SPSS 11.0 statistical analysis software was used for univariate and multivariate analysis. Results The mean age is 59 years (20 years-86 years, adenocarcinoma account for 80.2% (434/541. The median OS was 15 months (95%CI: 13.87-16.13, and 1, 2, 5-year survival rates were 58.8%, 23.7% and 3.20% respectively. Univariate analysis showed that clinical stage, ECOG score, weight loss, clinical symptoms, liver/bone/brain metastasis and received more than one chemotherapy regimen, good response to the first-line chemotherapy, EGFR-TKI targeted therapy and radiotherapy treatment were significantly correlated with the OS and survival rate (P < 0.05. Combined with multivariate analysis, weight loss before treatment, ECOG score, received EGFR-TKI targeted therapy and response to first-line chemotherapy were independent prognostic factor for survival (P < 0.05. Conclusion There is a higher percentage of adenocarcinoma in female NSCLC. Weight loss before treatment, ECOG score, EGFR-TKI targeted therapy and response to first-line chemotherapy may become independent prognostic factors for survival of female patients with advanced NSCLC.

  10. Advanced Maya texturing and lighting

    CERN Document Server

    Lanier, Lee

    2015-01-01

    Level up your skills with powerful texturing and lighting techniques Advanced Maya Texturing and Lighting, Third Edition leads you through the latest advanced techniques for adding realistic detail to your models. This new edition is up-to-date with the latest Maya texturing, lighting, and rendering features, including an exploration of the Node Editor, new Maya utility nodes and expanded coverage of mental ray shaders, and render settings. The proven tutorials are culled from real-world experience and refined to give you the ultimate in practical skills. You'll learn workflow t

  11. Latest results in rare decays at LHCb

    CERN Document Server

    Kreps, Michal

    2014-01-01

    Recent results from the LHCb experiment on decays governed by $b \\rightarrow s\\mu^+\\mu^-$ or $b\\rightarrow s\\gamma$ transitions are reviewed. The updated isospin asymmetry in $B \\rightarrow K^{(*)} \\mu^+\\mu^-$ decay are in good agreement with the Standard Model. Results of the angular analysis of $B \\rightarrow K\\mu^+ \\mu^-$ decay help to exclude large cancellation between left- and right-handed couplings in the $B^0_s \\rightarrow \\mu^+\\mu^-$ decay. Finally using the decay $B^+ \\rightarrow K^+\\pi^-\\pi^+\\gamma$, nonzero photon polarization is observed for the first time in $b\\rightarrow s\\gamma$ transitions.

  12. Analysis and Implication of the Latest Strategic Plans of British Universities Li-braries%英国大学图书馆最新战略规划的分析与启示

    Institute of Scientific and Technical Information of China (English)

    石笑; 贡金涛

    2016-01-01

    The strategic plan of library is important for effective implementation of library management. Through online survey and statistical analysis, this paper comparatively examined 15 pieces of strategic plans of British universities li-braries as research samples from the perspectives including strategic making subject, strategic development orientation and strategic content, and then reaches some conclusions and inspiration in order to provide some theoretical references for formulating strategic plans and developing new services of Chinese university libraries.%图书馆战略规划关系到图书馆管理的有效进行。文章主要运用网络调研和统计分析方法,按照战略制定主体、战略发展方向、战略内容等维度,对15份英国高校图书馆战略规划样本进行对比分析,进而得出若干研究结论和发展启示,以期为我国高校图书馆制定战略规划和开展新型服务提供必要的理论参考。

  13. Semantic multimedia analysis and processing

    CERN Document Server

    Spyrou, Evaggelos; Mylonas, Phivos

    2014-01-01

    Broad in scope, Semantic Multimedia Analysis and Processing provides a complete reference of techniques, algorithms, and solutions for the design and the implementation of contemporary multimedia systems. Offering a balanced, global look at the latest advances in semantic indexing, retrieval, analysis, and processing of multimedia, the book features the contributions of renowned researchers from around the world. Its contents are based on four fundamental thematic pillars: 1) information and content retrieval, 2) semantic knowledge exploitation paradigms, 3) multimedia personalization, and 4)

  14. Analysis of the Latest Strategic Development Direction of Foreign University Libraries%国外大学图书馆最新战略发展方向分析

    Institute of Scientific and Technical Information of China (English)

    谢黎; 邓勇; 张苏闽

    2012-01-01

    This paper analyzes strategic plans of 9 foreign university libraries with the method of content analysis,and finds out that their strategic development directions could be divided into three groups according to the importance: the core strategic direction,the specified strategic direction and the personalized strategic direction.The core strategic direction reflects the mission of university libraries,the specified strategic direction reflects development trends of entire library field,and the personalized strategic direction shows characteristics of university libraries.The formulation of library strategic plans in China should keep up with the development of foreign libraries,define library missions,grasp trends of the library field,and reflect unique features of university libraries.%通过对国外9所大学图书馆战略规划的内容分析研究可知,大学图书馆的战略发展方向根据其重要程度可归纳为核心战略方向、特色战略方向和个性战略方向。核心战略方向是大学图书馆本质使命的体现,特色战略方向反映了整个行业的发展趋势,个性战略方向彰显了图书馆的特色。我国图书馆战略的制定应把握国外图书馆发展动向,明确自身使命,把握行业趋势,体现本馆特色。

  15. Comparison of a Traditional Probabilistic Risk Assessment Approach with Advanced Safety Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Curtis L; Mandelli, Diego; Zhegang Ma

    2014-11-01

    As part of the Light Water Sustainability Program (LWRS) [1], the purpose of the Risk Informed Safety Margin Characterization (RISMC) [2] Pathway research and development (R&D) is to support plant decisions for risk-informed margin management with the aim to improve economics, reliability, and sustain safety of current NPPs. In this paper, we describe the RISMC analysis process illustrating how mechanistic and probabilistic approaches are combined in order to estimate a safety margin. We use the scenario of a “station blackout” (SBO) wherein offsite power and onsite power is lost, thereby causing a challenge to plant safety systems. We describe the RISMC approach, illustrate the station blackout modeling, and contrast this with traditional risk analysis modeling for this type of accident scenario. We also describe our approach we are using to represent advanced flooding analysis.

  16. Linking Advanced Visualization and MATLAB for the Analysis of 3D Gene Expression Data

    Energy Technology Data Exchange (ETDEWEB)

    Ruebel, Oliver; Keranen, Soile V.E.; Biggin, Mark; Knowles, David W.; Weber, Gunther H.; Hagen, Hans; Hamann, Bernd; Bethel, E. Wes

    2011-03-30

    Three-dimensional gene expression PointCloud data generated by the Berkeley Drosophila Transcription Network Project (BDTNP) provides quantitative information about the spatial and temporal expression of genes in early Drosophila embryos at cellular resolution. The BDTNP team visualizes and analyzes Point-Cloud data using the software application PointCloudXplore (PCX). To maximize the impact of novel, complex data sets, such as PointClouds, the data needs to be accessible to biologists and comprehensible to developers of analysis functions. We address this challenge by linking PCX and Matlab via a dedicated interface, thereby providing biologists seamless access to advanced data analysis functions and giving bioinformatics researchers the opportunity to integrate their analysis directly into the visualization application. To demonstrate the usefulness of this approach, we computationally model parts of the expression pattern of the gene even skipped using a genetic algorithm implemented in Matlab and integrated into PCX via our Matlab interface.

  17. Multielemental speciation analysis by advanced hyphenated technique - HPLC/ICP-MS: A review.

    Science.gov (United States)

    Marcinkowska, Monika; Barałkiewicz, Danuta

    2016-12-01

    Speciation analysis has become an invaluable tool in human health risk assessment, environmental monitoring or food quality control. Another step is to develop reliable multielemental speciation methodologies, to reduce costs, waste and time needed for the analysis. Separation and detection of species of several elements in a single analytical run can be accomplished by high performance liquid chromatography hyphenated to inductively coupled plasma mass spectrometry (HPLC/ICP-MS). Our review assembles articles concerning multielemental speciation determination of: As, Se, Cr, Sb, I, Br, Pb, Hg, V, Mo, Te, Tl, Cd and W in environmental, biological, food and clinical samples analyzed with HPLC/ICP-MS. It addresses the procedures in terms of following issues: sample collection and pretreatment, selection of optimal conditions for elements species separation by HPLC and determination using ICP-MS as well as metrological approach. The presented work is the first review article concerning multielemental speciation analysis by advanced hyphenated technique HPLC/ICP-MS.

  18. Solar Site Survey for the Advanced Technology Solar Telecope. I. Analysis of the Seeing Data

    CERN Document Server

    Socas-Navarro, H; Brandt, P; Briggs, J; Brown, T; Brown, W; Collados, M; Denker, C; Fletcher, S; Hegwer, S; Hill, F; Horst, T; Komsa, M; Kühn, J; Lecinski, A; Lin, H; Oncley, S; Penn, M; Rimmele, T; Streander, K

    2005-01-01

    The site survey for the Advanced Technology Solar Telescope concluded recently after more than two years of data gathering and analysis. Six locations, including lake, island and continental sites, were thoroughly probed for image quality and sky brightness. The present paper describes the analysis methodology employed to determine the height stratification of the atmospheric turbulence. This information is crucial because day-time seeing is often very different between the actual telescope aperture (~30 m) and the ground. Two independent inversion codes have been developed to analyze simultaneously data from a scintillometer array and a solar differential image monitor. We show here the results of applying them to a sample subset of data from May 2003, which was used for testing. Both codes retrieve a similar seeing stratification through the height range of interest. A quantitative comparison between our analysis procedure and actual in situ measurements confirms the validity of the inversions. The sample d...

  19. Excursions in classical analysis pathways to advanced problem solving and undergraduate research

    CERN Document Server

    Chen, Hongwei

    2010-01-01

    Excursions in Classical Analysis introduces undergraduate students to advanced problem solving and undergraduate research in two ways. Firstly, it provides a colourful tour of classical analysis which places a wide variety of problems in their historical context. Secondly, it helps students gain an understanding of mathematical discovery and proof. In demonstrating a variety of possible solutions to the same sample exercise, the reader will come to see how the connections between apparently inapplicable areas of mathematics can be exploited in problem-solving. This book will serve as excellent preparation for participation in mathematics competitions, as a valuable resource for undergraduate mathematics reading courses and seminars and as a supplement text in a course on analysis. It can also be used in independent study, since the chapters are free-standing.

  20. Advances in chaos theory and intelligent control

    CERN Document Server

    Vaidyanathan, Sundarapandian

    2016-01-01

    The book reports on the latest advances in and applications of chaos theory and intelligent control. Written by eminent scientists and active researchers and using a clear, matter-of-fact style, it covers advanced theories, methods, and applications in a variety of research areas, and explains key concepts in modeling, analysis, and control of chaotic and hyperchaotic systems. Topics include fractional chaotic systems, chaos control, chaos synchronization, memristors, jerk circuits, chaotic systems with hidden attractors, mechanical and biological chaos, and circuit realization of chaotic systems. The book further covers fuzzy logic controllers, evolutionary algorithms, swarm intelligence, and petri nets among other topics. Not only does it provide the readers with chaos fundamentals and intelligent control-based algorithms; it also discusses key applications of chaos as well as multidisciplinary solutions developed via intelligent control. The book is a timely and comprehensive reference guide for graduate s...

  1. Advanced functionality for radio analysis in the Offline software framework of the Pierre Auger Observatory

    Science.gov (United States)

    Abreu, P.; Aglietta, M.; Ahn, E. J.; Albuquerque, I. F. M.; Allard, D.; Allekotte, I.; Allen, J.; Allison, P.; Alvarez Castillo, J.; Alvarez-Muñiz, J.; Ambrosio, M.; Aminaei, A.; Anchordoqui, L.; Andringa, S.; Antičić, T.; Aramo, C.; Arganda, E.; Arqueros, F.; Asorey, H.; Assis, P.; Aublin, J.; Ave, M.; Avenier, M.; Avila, G.; Bäcker, T.; Balzer, M.; Barber, K. B.; Barbosa, A. F.; Bardenet, R.; Barroso, S. L. C.; Baughman, B.; Beatty, J. J.; Becker, B. R.; Becker, K. H.; Bellido, J. A.; Benzvi, S.; Berat, C.; Bertou, X.; Biermann, P. L.; Billoir, P.; Blanco, F.; Blanco, M.; Bleve, C.; Blümer, H.; Boháčová, M.; Boncioli, D.; Bonifazi, C.; Bonino, R.; Borodai, N.; Brack, J.; Brogueira, P.; Brown, W. C.; Bruijn, R.; Buchholz, P.; Bueno, A.; Burton, R. E.; Caballero-Mora, K. S.; Caramete, L.; Caruso, R.; Castellina, A.; Cataldi, G.; Cazon, L.; Cester, R.; Chauvin, J.; Chiavassa, A.; Chinellato, J. A.; Chou, A.; Chudoba, J.; Clay, R. W.; Coluccia, M. R.; Conceição, R.; Contreras, F.; Cook, H.; Cooper, M. J.; Coppens, J.; Cordier, A.; Cotti, U.; Coutu, S.; Covault, C. E.; Creusot, A.; Criss, A.; Cronin, J.; Curutiu, A.; Dagoret-Campagne, S.; Dallier, R.; Dasso, S.; Daumiller, K.; Dawson, B. R.; de Almeida, R. M.; de Domenico, M.; de Donato, C.; de Jong, S. J.; de La Vega, G.; de Mello Junior, W. J. M.; de Mello Neto, J. R. T.; de Mitri, I.; de Souza, V.; de Vries, K. D.; Decerprit, G.; Del Peral, L.; Deligny, O.; Dembinski, H.; Denkiewicz, A.; di Giulio, C.; Diaz, J. C.; Díaz Castro, M. L.; Diep, P. N.; Dobrigkeit, C.; D'Olivo, J. C.; Dong, P. N.; Dorofeev, A.; Dos Anjos, J. C.; Dova, M. T.; D'Urso, D.; Dutan, I.; Ebr, J.; Engel, R.; Erdmann, M.; Escobar, C. O.; Etchegoyen, A.; Facal San Luis, P.; Falcke, H.; Farrar, G.; Fauth, A. C.; Fazzini, N.; Ferguson, A. P.; Ferrero, A.; Fick, B.; Filevich, A.; Filipčič, A.; Fliescher, S.; Fracchiolla, C. E.; Fraenkel, E. D.; Fröhlich, U.; Fuchs, B.; Gamarra, R. F.; Gambetta, S.; García, B.; García Gámez, D.; Garcia-Pinto, D.; Gascon, A.; Gemmeke, H.; Gesterling, K.; Ghia, P. L.; Giaccari, U.; Giller, M.; Glass, H.; Gold, M. S.; Golup, G.; Gomez Albarracin, F.; Gómez Berisso, M.; Gonçalves, P.; Gonzalez, D.; Gonzalez, J. G.; Gookin, B.; Góra, D.; Gorgi, A.; Gouffon, P.; Gozzini, S. R.; Grashorn, E.; Grebe, S.; Griffith, N.; Grigat, M.; Grillo, A. F.; Guardincerri, Y.; Guarino, F.; Guedes, G. P.; Hague, J. D.; Hansen, P.; Harari, D.; Harmsma, S.; Harton, J. L.; Haungs, A.; Hebbeker, T.; Heck, D.; Herve, A. E.; Hojvat, C.; Holmes, V. C.; Homola, P.; Hörandel, J. R.; Horneffer, A.; Hrabovský, M.; Huege, T.; Insolia, A.; Ionita, F.; Italiano, A.; Jiraskova, S.; Kadija, K.; Kampert, K. H.; Karhan, P.; Karova, T.; Kasper, P.; Kégl, B.; Keilhauer, B.; Keivani, A.; Kelley, J. L.; Kemp, E.; Kieckhafer, R. M.; Klages, H. O.; Kleifges, M.; Kleinfeller, J.; Knapp, J.; Koang, D.-H.; Kotera, K.; Krohm, N.; Krömer, O.; Kruppke-Hansen, D.; Kuehn, F.; Kuempel, D.; Kulbartz, J. K.; Kunka, N.; La Rosa, G.; Lachaud, C.; Lautridou, P.; Leão, M. S. A. B.; Lebrun, D.; Lebrun, P.; Leigui de Oliveira, M. A.; Lemiere, A.; Letessier-Selvon, A.; Lhenry-Yvon, I.; Link, K.; López, R.; Lopez Agüera, A.; Louedec, K.; Lozano Bahilo, J.; Lucero, A.; Ludwig, M.; Lyberis, H.; Macolino, C.; Maldera, S.; Mandat, D.; Mantsch, P.; Mariazzi, A. G.; Marin, V.; Maris, I. C.; Marquez Falcon, H. R.; Marsella, G.; Martello, D.; Martin, L.; Martínez Bravo, O.; Mathes, H. J.; Matthews, J.; Matthews, J. A. J.; Matthiae, G.; Maurizio, D.; Mazur, P. O.; Medina-Tanco, G.; Melissas, M.; Melo, D.; Menichetti, E.; Menshikov, A.; Mertsch, P.; Meurer, C.; Mićanović, S.; Micheletti, M. I.; Miller, W.; Miramonti, L.; Mollerach, S.; Monasor, M.; Monnier Ragaigne, D.; Montanet, F.; Morales, B.; Morello, C.; Moreno, E.; Moreno, J. C.; Morris, C.; Mostafá, M.; Moura, C. A.; Mueller, S.; Muller, M. A.; Müller, G.; Münchmeyer, M.; Mussa, R.; Navarra, G.; Navarro, J. L.; Navas, S.; Necesal, P.; Nellen, L.; Nelles, A.; Nhung, P. T.; Nierstenhoefer, N.; Nitz, D.; Nosek, D.; Nožka, L.; Nyklicek, M.; Oehlschläger, J.; Olinto, A.; Oliva, P.; Olmos-Gilbaja, V. M.; Ortiz, M.; Pacheco, N.; Pakk Selmi-Dei, D.; Palatka, M.; Pallotta, J.; Palmieri, N.; Parente, G.; Parizot, E.; Parra, A.; Parrisius, J.; Parsons, R. D.; Pastor, S.; Paul, T.; Pech, M.; PeĶala, J.; Pelayo, R.; Pepe, I. M.; Perrone, L.; Pesce, R.; Petermann, E.; Petrera, S.; Petrinca, P.; Petrolini, A.; Petrov, Y.; Petrovic, J.; Pfendner, C.; Phan, N.; Piegaia, R.; Pierog, T.; Pieroni, P.; Pimenta, M.; Pirronello, V.; Platino, M.; Ponce, V. H.; Pontz, M.; Privitera, P.; Prouza, M.; Quel, E. J.; Rautenberg, J.; Ravel, O.; Ravignani, D.; Revenu, B.; Ridky, J.; Risse, M.; Ristori, P.; Rivera, H.; Riviére, C.; Rizi, V.; Robledo, C.; Rodrigues de Carvalho, W.; Rodriguez, G.; Rodriguez Martino, J.; Rodriguez Rojo, J.; Rodriguez-Cabo, I.; Rodríguez-Frías, M. D.; Ros, G.; Rosado, J.; Rossler, T.; Roth, M.; Rouillé-D'Orfeuil, B.; Roulet, E.; Rovero, A. C.; Rühle, C.; Salamida, F.; Salazar, H.; Salina, G.; Sánchez, F.; Santander, M.; Santo, C. E.; Santos, E.; Santos, E. M.; Sarazin, F.; Sarkar, S.; Sato, R.; Scharf, N.; Scherini, V.; Schieler, H.; Schiffer, P.; Schmidt, A.; Schmidt, F.; Schmidt, T.; Scholten, O.; Schoorlemmer, H.; Schovancova, J.; Schovánek, P.; Schroeder, F.; Schulte, S.; Schuster, D.; Sciutto, S. J.; Scuderi, M.; Segreto, A.; Semikoz, D.; Settimo, M.; Shadkam, A.; Shellard, R. C.; Sidelnik, I.; Sigl, G.; Śmiałkowski, A.; Šmída, R.; Snow, G. R.; Sommers, P.; Sorokin, J.; Spinka, H.; Squartini, R.; Stapleton, J.; Stasielak, J.; Stephan, M.; Stutz, A.; Suarez, F.; Suomijärvi, T.; Supanitsky, A. D.; Šuša, T.; Sutherland, M. S.; Swain, J.; Szadkowski, Z.; Szuba, M.; Tamashiro, A.; Tapia, A.; Taşcău, O.; Tcaciuc, R.; Tegolo, D.; Thao, N. T.; Thomas, D.; Tiffenberg, J.; Timmermans, C.; Tiwari, D. K.; Tkaczyk, W.; Todero Peixoto, C. J.; Tomé, B.; Tonachini, A.; Travnicek, P.; Tridapalli, D. B.; Tristram, G.; Trovato, E.; Tueros, M.; Ulrich, R.; Unger, M.; Urban, M.; Valdés Galicia, J. F.; Valiño, I.; Valore, L.; van den Berg, A. M.; Vargas Cárdenas, B.; Vázquez, J. R.; Vázquez, R. A.; Veberič, D.; Verzi, V.; Videla, M.; Villaseñor, L.; Wahlberg, H.; Wahrlich, P.; Wainberg, O.; Warner, D.; Watson, A. A.; Weber, M.; Weidenhaupt, K.; Weindl, A.; Westerhoff, S.; Whelan, B. J.; Wieczorek, G.; Wiencke, L.; Wilczyńska, B.; Wilczyński, H.; Will, M.; Williams, C.; Winchen, T.; Winders, L.; Winnick, M. G.; Wommer, M.; Wundheiler, B.; Yamamoto, T.; Younk, P.; Yuan, G.; Zamorano, B.; Zas, E.; Zavrtanik, D.; Zavrtanik, M.; Zaw, I.; Zepeda, A.; Ziolkowski, M.

    2011-04-01

    The advent of the Auger Engineering Radio Array (AERA) necessitates the development of a powerful framework for the analysis of radio measurements of cosmic ray air showers. As AERA performs “radio-hybrid” measurements of air shower radio emission in coincidence with the surface particle detectors and fluorescence telescopes of the Pierre Auger Observatory, the radio analysis functionality had to be incorporated in the existing hybrid analysis solutions for fluorescence and surface detector data. This goal has been achieved in a natural way by extending the existing Auger Offline software framework with radio functionality. In this article, we lay out the design, highlights and features of the radio extension implemented in the Auger Offline framework. Its functionality has achieved a high degree of sophistication and offers advanced features such as vectorial reconstruction of the electric field, advanced signal processing algorithms, a transparent and efficient handling of FFTs, a very detailed simulation of detector effects, and the read-in of multiple data formats including data from various radio simulation codes. The source code of this radio functionality can be made available to interested parties on request.

  2. Structural analysis of advanced polymeric foams by means of high resolution X-ray computed tomography

    Science.gov (United States)

    Nacucchi, M.; De Pascalis, F.; Scatto, M.; Capodieci, L.; Albertoni, R.

    2016-06-01

    Advanced polymeric foams with enhanced thermal insulation and mechanical properties are used in a wide range of industrial applications. The properties of a foam strongly depend upon its cell structure. Traditionally, their microstructure has been studied using 2D imaging systems based on optical or electron microscopy, with the obvious disadvantage that only the surface of the sample can be analysed. To overcome this shortcoming, the adoption of X-ray micro-tomography imaging is here suggested to allow for a complete 3D, non-destructive analysis of advanced polymeric foams. Unlike metallic foams, the resolution of the reconstructed structural features is hampered by the low contrast in the images due to weak X-ray absorption in the polymer. In this work an advanced methodology based on high-resolution and low-contrast techniques is used to perform quantitative analyses on both closed and open cells foams. Local structural features of individual cells such as equivalent diameter, sphericity, anisotropy and orientation are statistically evaluated. In addition, thickness and length of the struts are determined, underlining the key role played by the achieved resolution. In perspective, the quantitative description of these structural features will be used to evaluate the results of in situ mechanical and thermal test on foam samples.

  3. An analysis of cost effective incentives for initial commercial deployment of advanced clean coal technologies

    Energy Technology Data Exchange (ETDEWEB)

    Spencer, D.F. [SIMTECHE, Half Moon Bay, CA (United States)

    1997-12-31

    This analysis evaluates the incentives necessary to introduce commercial scale Advanced Clean Coal Technologies, specifically Integrated Coal Gasification Combined Cycle (ICGCC) and Pressurized Fluidized Bed Combustion (PFBC) powerplants. The incentives required to support the initial introduction of these systems are based on competitive busbar electricity costs with natural gas fired combined cycle powerplants, in baseload service. A federal government price guarantee program for up to 10 Advanced Clean Coal Technology powerplants, 5 each ICGCC and PFBC systems is recommended in order to establish the commercial viability of these systems by 2010. By utilizing a decreasing incentives approach as the technologies mature (plants 1--5 of each type), and considering the additional federal government benefits of these plants versus natural gas fired combined cycle powerplants, federal government net financial exposure is minimized. Annual net incentive outlays of approximately 150 million annually over a 20 year period could be necessary. Based on increased demand for Advanced Clean Coal Technologies beyond 2010, the federal government would be revenue neutral within 10 years of the incentives program completion.

  4. Advanced Techniques in Web Intelligence-2 Web User Browsing Behaviour and Preference Analysis

    CERN Document Server

    Palade, Vasile; Jain, Lakhmi

    2013-01-01

    This research volume focuses on analyzing the web user browsing behaviour and preferences in traditional web-based environments, social  networks and web 2.0 applications,  by using advanced  techniques in data acquisition, data processing, pattern extraction and  cognitive science for modeling the human actions.  The book is directed to  graduate students, researchers/scientists and engineers  interested in updating their knowledge with the recent trends in web user analysis, for developing the next generation of web-based systems and applications.

  5. Advancing genetic theory and application by metabolic quantitative trait loci analysis.

    Science.gov (United States)

    Kliebenstein, Danielj

    2009-06-01

    This review describes recent advances in the analysis of metabolism using quantitative genetics. It focuses on how recent metabolic quantitative trait loci (QTL) studies enhance our understanding of the genetic architecture underlying naturally variable phenotypes and the impact of this fundamental research on agriculture, specifically crop breeding. In particular, the role of whole-genome duplications in generating quantitative genetic variation within a species is highlighted and the potential uses of this phenomenon presented. Additionally, the review describes how new observations from metabolic QTL mapping analyses are helping to shape and expand the concepts of genetic epistasis.

  6. Analysis of Advanced Modular Power Systems (AMPS) for Deep Space Exploration

    Science.gov (United States)

    Oeftering, Richard; Soeder, James F.; Beach, Ray

    2014-01-01

    The Advanced Modular Power Systems (AMPS) project is developing a modular approach to spacecraft power systems for exploration beyond Earth orbit. AMPS is intended to meet the need of reducing the cost of design development, test and integration and also reducing the operational logistics cost of supporting exploration missions. AMPS seeks to establish modular power building blocks with standardized electrical, mechanical, thermal and data interfaces that can be applied across multiple exploration vehicles. The presentation discusses the results of a cost analysis that compares the cost of the modular approach against a traditional non-modular approach.

  7. Advances in coupled safety modeling using systems analysis and high-fidelity methods.

    Energy Technology Data Exchange (ETDEWEB)

    Fanning, T. H.; Thomas, J. W.; Nuclear Engineering Division

    2010-05-31

    The potential for a sodium-cooled fast reactor to survive severe accident initiators with no damage has been demonstrated through whole-plant testing in EBR-II and FFTF. Analysis of the observed natural protective mechanisms suggests that they would be characteristic of a broad range of sodium-cooled fast reactors utilizing metal fuel. However, in order to demonstrate the degree to which new, advanced sodium-cooled fast reactor designs will possess these desired safety features, accurate, high-fidelity, whole-plant dynamics safety simulations will be required. One of the objectives of the advanced safety-modeling component of the Reactor IPSC is to develop a science-based advanced safety simulation capability by utilizing existing safety simulation tools coupled with emerging high-fidelity modeling capabilities in a multi-resolution approach. As part of this integration, an existing whole-plant systems analysis code has been coupled with a high-fidelity computational fluid dynamics code to assess the impact of high-fidelity simulations on safety-related performance. With the coupled capabilities, it is possible to identify critical safety-related phenomenon in advanced reactor designs that cannot be resolved with existing tools. In this report, the impact of coupling is demonstrated by evaluating the conditions of outlet plenum thermal stratification during a protected loss of flow transient. Outlet plenum stratification was anticipated to alter core temperatures and flows predicted during natural circulation conditions. This effect was observed during the simulations. What was not anticipated, however, is the far-reaching impact that resolving thermal stratification has on the whole plant. The high temperatures predicted at the IHX inlet due to thermal stratification in the outlet plenum forces heat into the intermediate system to the point that it eventually becomes a source of heat for the primary system. The results also suggest that flow stagnation in the

  8. Critical feminist narrative inquiry: advancing knowledge through double-hermeneutic narrative analysis.

    Science.gov (United States)

    Pitre, Nicole Y; Kushner, Kaysi E; Raine, Kim D; Hegadoren, Kathy M

    2013-01-01

    Critical feminist narrative inquiry is informed by the theoretical triangulation of critical, feminist, and symbolic interactionist perspectives. We first locate this approach within narrative research and identify the epistemological underpinnings and assumptions supporting this innovative methodology. The analytic and interpretive objectives and processes involved to achieve a double-hermeneutic narrative analysis are detailed. We conclude by proposing that this novel approach is suitable to advance knowledge about the nature and context of individual experiences, to expose circumstances leading to social injustice and health inequities, and ultimately to contribute to improved health outcomes for traditionally silenced, marginalized, or vulnerable populations.

  9. 3D analysis of condylar remodelling and skeletal relapse following bilateral sagittal split advancement osteotomies.

    Science.gov (United States)

    Xi, Tong; Schreurs, Ruud; van Loon, Bram; de Koning, Martien; Bergé, Stefaan; Hoppenreijs, Theo; Maal, Thomas

    2015-05-01

    A major concern in mandibular advancement surgery using bilateral sagittal split osteotomies (BSSO) is potential postoperative relapse. Although the role of postoperative changes in condylar morphology on skeletal relapse was reported in previous studies, no study so far has objectified the precise changes of the condylar volume. The aim of the present study was to quantify the postoperative volume changes of condyles and its role on skeletal stability following BSSO mandibular advancement surgery. A total of 56 patients with mandibular hypoplasia who underwent BSSO advancement surgery were prospectively enrolled into the study. A cone beam computed tomography (CBCT) scan was acquired preoperatively, at 1 week postoperatively and at 1 year postoperatively. After the segmentation of the facial skeleton and condyles, three-dimensional cephalometry and condylar volume analysis were performed. The mean mandibular advancement was 4.6 mm, and the mean postoperative relapse was 0.71 mm. Of 112 condyles, 55% showed a postoperative decrease in condylar volume, with a mean reduction of 105 mm(3) (6.1% of the original condylar volume). The magnitude of condylar remodelling (CR) was significantly correlated with skeletal relapse (p = 0.003). Patients with a CR greater than 17% of the original condylar volume exhibited relapse as seen in progressive condylar resorption. Female patients with a high mandibular angle who exhibited postoperative CR were particularly at risk for postoperative relapse. Gender, preoperative condylar volume, and downward displacement of pogonion at surgery were prognostic factors for CR (r(2) = 21%). It could be concluded that the condylar volume can be applied as a useful 3D radiographic parameter for the diagnosis and follow-up of postoperative skeletal relapse and progressive condylar resorption.

  10. Use Of The SYSCAP 2.5 Computer Analysis Program For Advanced Optical System Design And Analysis

    Science.gov (United States)

    Kleiner, C. T.

    1983-10-01

    The successful development of various electro-optical systems is highly dependent on precise electronic circuit design which must account for possible parameter drift in the various piece parts. The utilization of a comprehensive computer analysis program (SYSCAP) provides the electro-optical system designer and electro-optical management organization with a well-structured tool for a comprehensive system analysis'. As a result, the techniques described in this paper can be readily used by the electro-optical design community. An improved version of the SYSCAP computer program (version 2.5) is presented which inncludes the following new advances: (1) the introduction of a standard macro library that permits call-up of proven mathematical models for system modeling and simulation, (2) the introduction of improved semiconductor models for bipolar junction transistors and p-n junctions, (3) multifunction modeling capability to link signals with very high speed electronic circuit models, (4) high resolution computer graphics (both interactive and batch process) for display and permanent records, and (5) compatibility and interface with ad-vanced engineering work stations. This 2.5* version of the present SYSCAP 2 computer analysis program will be available for use through the Control Data Corporation world-wide Cybernet system in 1983*. This paper provides an overview of SYSCAP modeling and simulation capabilities.

  11. Advances in liquid chromatography-high-resolution mass spectrometry for quantitative and qualitative environmental analysis.

    Science.gov (United States)

    Aceña, Jaume; Stampachiacchiere, Serena; Pérez, Sandra; Barceló, Damià

    2015-08-01

    This review summarizes the advances in environmental analysis by liquid chromatography-high-resolution mass spectrometry (LC-HRMS) during the last decade and discusses different aspects of their application. LC-HRMS has become a powerful tool for simultaneous quantitative and qualitative analysis of organic pollutants, enabling their quantitation and the search for metabolites and transformation products or the detection of unknown compounds. LC-HRMS provides more information than low-resolution (LR) MS for each sample because it can accurately determine the mass of the molecular ion and its fragment ions if it can be used for MS-MS. Another advantage is that the data can be processed using either target analysis, suspect screening, retrospective analysis, or non-target screening. With the growing popularity and acceptance of HRMS analysis, current guidelines for compound confirmation need to be revised for quantitative and qualitative purposes. Furthermore, new commercial software and user-built libraries are required to mine data in an efficient and comprehensive way. The scope of this critical review is not to provide a comprehensive overview of the many studies performed with LC-HRMS in the field of environmental analysis, but to reveal its advantages and limitations using different workflows.

  12. Advanced grazing-incidence techniques for modern soft-matter materials analysis

    Directory of Open Access Journals (Sweden)

    Alexander Hexemer

    2015-01-01

    Full Text Available The complex nano-morphology of modern soft-matter materials is successfully probed with advanced grazing-incidence techniques. Based on grazing-incidence small- and wide-angle X-ray and neutron scattering (GISAXS, GIWAXS, GISANS and GIWANS, new possibilities arise which are discussed with selected examples. Due to instrumental progress, highly interesting possibilities for local structure analysis in this material class arise from the use of micro- and nanometer-sized X-ray beams in micro- or nanofocused GISAXS and GIWAXS experiments. The feasibility of very short data acquisition times down to milliseconds creates exciting possibilities for in situ and in operando GISAXS and GIWAXS studies. Tuning the energy of GISAXS and GIWAXS in the soft X-ray regime and in time-of flight GISANS allows the tailoring of contrast conditions and thereby the probing of more complex morphologies. In addition, recent progress in software packages, useful for data analysis for advanced grazing-incidence techniques, is discussed.

  13. Backside versus frontside advanced chemical analysis of high-k/metal gate stacks

    Energy Technology Data Exchange (ETDEWEB)

    Martinez, E., E-mail: eugenie.martinez@cea.fr [Univ Grenoble Alpes, F-38000 Grenoble (France); CEA, LETI, MINATEC Campus, F-38054 Grenoble (France); Saidi, B. [STMicroelectronics, 850 rue Jean Monnet, 38926 Rousset Cedex, Crolles (France); Veillerot, M. [Univ Grenoble Alpes, F-38000 Grenoble (France); CEA, LETI, MINATEC Campus, F-38054 Grenoble (France); Caubet, P. [STMicroelectronics, 850 rue Jean Monnet, 38926 Rousset Cedex, Crolles (France); Fabbri, J-M. [Univ Grenoble Alpes, F-38000 Grenoble (France); CEA, LETI, MINATEC Campus, F-38054 Grenoble (France); Piallat, F. [STMicroelectronics, 850 rue Jean Monnet, 38926 Rousset Cedex, Crolles (France); Gassilloud, R. [Univ Grenoble Alpes, F-38000 Grenoble (France); CEA, LETI, MINATEC Campus, F-38054 Grenoble (France); Schamm-Chardon, S. [CEMES-CNRS et Université de Toulouse, 29 rue Jeanne Marvig, 31055 Toulouse (France)

    2015-08-15

    Highlights: • The backside approach is a promising solution for advanced chemical characterization of future MOSFETs. • Frontside ToF-SIMS and Auger depth profiles are affected by cumulative mixing effects and thus not relevant for analyzing ultra-thin layers. • Higher in-depth resolution is possible in the backside approach for Auger and ToF-SIMS depth profiling. • Backside depth profiling allows revealing ultra-thin layers and elemental in-depth redistribution inside high-k/metal gate stacks. • Backside XPS allows preserving the full metal gate, thus enabling the analysis of real technological samples. - Abstract: Downscaling of transistors beyond the 14 nm technological node requires the implementation of new architectures and materials. Advanced characterization methods are needed to gain information about the chemical composition of buried layers and interfaces. An effective approach based on backside analysis is presented here. X-ray photoelectron spectroscopy, Auger depth profiling and time-of-flight secondary ions mass spectrometry are combined to investigate inter-diffusion phenomena. To highlight improvements related to the backside method, backside and frontside analyses are compared. Critical information regarding nitrogen, oxygen and aluminium redistribution inside the gate stacks is obtained only in the backside configuration.

  14. Advanced grazing-incidence techniques for modern soft-matter materials analysis.

    Science.gov (United States)

    Hexemer, Alexander; Müller-Buschbaum, Peter

    2015-01-01

    The complex nano-morphology of modern soft-matter materials is successfully probed with advanced grazing-incidence techniques. Based on grazing-incidence small- and wide-angle X-ray and neutron scattering (GISAXS, GIWAXS, GISANS and GIWANS), new possibilities arise which are discussed with selected examples. Due to instrumental progress, highly interesting possibilities for local structure analysis in this material class arise from the use of micro- and nanometer-sized X-ray beams in micro- or nanofocused GISAXS and GIWAXS experiments. The feasibility of very short data acquisition times down to milliseconds creates exciting possibilities for in situ and in operando GISAXS and GIWAXS studies. Tuning the energy of GISAXS and GIWAXS in the soft X-ray regime and in time-of flight GISANS allows the tailoring of contrast conditions and thereby the probing of more complex morphologies. In addition, recent progress in software packages, useful for data analysis for advanced grazing-incidence techniques, is discussed.

  15. Development of a steady thermal-hydraulic analysis code for the China Advanced Research Reactor

    Institute of Scientific and Technical Information of China (English)

    TIAN Wenxi; QIU Suizheng; GUO Yun; SU Guanghui; JIA Dounan; LIU Tiancai; ZHANG Jianwei

    2007-01-01

    A multi-channel model steady-state thermalhydraulic analysis code was developed for the China Advanced Research Reactor (CARR). By simulating the whole reactor core, the detailed mass flow distribution in the core was obtained. The result shows that structure size plays the most important role in mass flow distribution, and the influence of core power could be neglected under singlephase flow. The temperature field of the fuel element under unsymmetrical cooling condition was also obtained, which is necessary for further study such as stress analysis, etc. Of the fuel element. At the same time, considering the hot channel effect including engineering factor and nuclear factor, calculation of the mean and hot channel was carried out and it is proved that all thermal-hydraulic parameters satisfy the "Safety design regulation of CARR".

  16. Advanced practice psychiatric nurses as a treatment resource: survey and analysis.

    Science.gov (United States)

    Feldman, Saul; Bachman, John; Cuffel, Brian; Friesen, Bernice; McCabe, John

    2003-07-01

    Access to behavioral health services, particularly pharmacotherapy, continues to be a significant problem. This is particularly the case for public sector beneficiaries and managed care members. The greater use of advanced practice psychiatric nurses (APPNs) with prescribing privileges could help. To better understand the availability and competence of APPNs to prescribe, the authors conducted 1) a national survey of APPNs' availability and prescribing practices, 2) a comparative analysis of pharmacy claims data generated by APPNs and psychiatrists, and 3) a comprehensive clinical record review comparing APPNs to psychiatrists. About 25% of the sample of APPNs reported having prescription authority and a private practice. The analysis of prescribing practices between APPNs and psychiatrists showed that with a few exceptions, there were no differences between the groups, as did a retrospective clinical record review. These results lead the authors to recommend greater efforts to increase the supply of APPNs.

  17. Running CMS remote analysis builder jobs on advanced resource connector middleware

    Science.gov (United States)

    Edelmann, E.; Happonen, K.; Koivumäki, J.; Lindén, T.; Välimaa, J.

    2011-12-01

    CMS user analysis jobs are distributed over the grid with the CMS Remote Analysis Builder application (CRAB). According to the CMS computing model the applications should run transparently on the different grid flavours in use. In CRAB this is handled with different plugins that are able to submit to different grids. Recently a CRAB plugin for submitting to the Advanced Resource Connector (ARC) middleware has been developed. The CRAB ARC plugin enables simple and fast job submission with full job status information available. CRAB can be used with a server which manages and monitors the grid jobs on behalf of the user. In the presentation we will report on the CRAB ARC plugin and on the status of integrating it with the CRAB server and compare this with using the gLite ARC interoperability method for job submission.

  18. Advanced Fuel Cycle Economic Analysis of Symbiotic Light-Water Reactor and Fast Burner Reactor Systems

    Energy Technology Data Exchange (ETDEWEB)

    D. E. Shropshire

    2009-01-01

    The Advanced Fuel Cycle Economic Analysis of Symbiotic Light-Water Reactor and Fast Burner Reactor Systems, prepared to support the U.S. Advanced Fuel Cycle Initiative (AFCI) systems analysis, provides a technology-oriented baseline system cost comparison between the open fuel cycle and closed fuel cycle systems. The intent is to understand their overall cost trends, cost sensitivities, and trade-offs. This analysis also improves the AFCI Program’s understanding of the cost drivers that will determine nuclear power’s cost competitiveness vis-a-vis other baseload generation systems. The common reactor-related costs consist of capital, operating, and decontamination and decommissioning costs. Fuel cycle costs include front-end (pre-irradiation) and back-end (post-iradiation) costs, as well as costs specifically associated with fuel recycling. This analysis reveals that there are large cost uncertainties associated with all the fuel cycle strategies, and that overall systems (reactor plus fuel cycle) using a closed fuel cycle are about 10% more expensive in terms of electricity generation cost than open cycle systems. The study concludes that further U.S. and joint international-based design studies are needed to reduce the cost uncertainties with respect to fast reactor, fuel separation and fabrication, and waste disposition. The results of this work can help provide insight to the cost-related factors and conditions needed to keep nuclear energy (including closed fuel cycles) economically competitive in the U.S. and worldwide. These results may be updated over time based on new cost information, revised assumptions, and feedback received from additional reviews.

  19. Advanced Mesh-Enabled Monte carlo capability for Multi-Physics Reactor Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, Paul; Evans, Thomas; Tautges, Tim

    2012-12-24

    This project will accumulate high-precision fluxes throughout reactor geometry on a non- orthogonal grid of cells to support multi-physics coupling, in order to more accurately calculate parameters such as reactivity coefficients and to generate multi-group cross sections. This work will be based upon recent developments to incorporate advanced geometry and mesh capability in a modular Monte Carlo toolkit with computational science technology that is in use in related reactor simulation software development. Coupling this capability with production-scale Monte Carlo radiation transport codes can provide advanced and extensible test-beds for these developments. Continuous energy Monte Carlo methods are generally considered to be the most accurate computational tool for simulating radiation transport in complex geometries, particularly neutron transport in reactors. Nevertheless, there are several limitations for their use in reactor analysis. Most significantly, there is a trade-off between the fidelity of results in phase space, statistical accuracy, and the amount of computer time required for simulation. Consequently, to achieve an acceptable level of statistical convergence in high-fidelity results required for modern coupled multi-physics analysis, the required computer time makes Monte Carlo methods prohibitive for design iterations and detailed whole-core analysis. More subtly, the statistical uncertainty is typically not uniform throughout the domain, and the simulation quality is limited by the regions with the largest statistical uncertainty. In addition, the formulation of neutron scattering laws in continuous energy Monte Carlo methods makes it difficult to calculate adjoint neutron fluxes required to properly determine important reactivity parameters. Finally, most Monte Carlo codes available for reactor analysis have relied on orthogonal hexahedral grids for tallies that do not conform to the geometric boundaries and are thus generally not well

  20. PREFACE: 16th International workshop on Advanced Computing and Analysis Techniques in physics research (ACAT2014)

    Science.gov (United States)

    Fiala, L.; Lokajicek, M.; Tumova, N.

    2015-05-01

    This volume of the IOP Conference Series is dedicated to scientific contributions presented at the 16th International Workshop on Advanced Computing and Analysis Techniques in Physics Research (ACAT 2014), this year the motto was ''bridging disciplines''. The conference took place on September 1-5, 2014, at the Faculty of Civil Engineering, Czech Technical University in Prague, Czech Republic. The 16th edition of ACAT explored the boundaries of computing system architectures, data analysis algorithmics, automatic calculations, and theoretical calculation technologies. It provided a forum for confronting and exchanging ideas among these fields, where new approaches in computing technologies for scientific research were explored and promoted. This year's edition of the workshop brought together over 140 participants from all over the world. The workshop's 16 invited speakers presented key topics on advanced computing and analysis techniques in physics. During the workshop, 60 talks and 40 posters were presented in three tracks: Computing Technology for Physics Research, Data Analysis - Algorithms and Tools, and Computations in Theoretical Physics: Techniques and Methods. The round table enabled discussions on expanding software, knowledge sharing and scientific collaboration in the respective areas. ACAT 2014 was generously sponsored by Western Digital, Brookhaven National Laboratory, Hewlett Packard, DataDirect Networks, M Computers, Bright Computing, Huawei and PDV-Systemhaus. Special appreciations go to the track liaisons Lorenzo Moneta, Axel Naumann and Grigory Rubtsov for their work on the scientific program and the publication preparation. ACAT's IACC would also like to express its gratitude to all referees for their work on making sure the contributions are published in the proceedings. Our thanks extend to the conference liaisons Andrei Kataev and Jerome Lauret who worked with the local contacts and made this conference possible as well as to the program

  1. Advances in geophysics

    CERN Document Server

    Sato, Haruo

    2012-01-01

    The critically acclaimed serialized review journal for over 50 years, Advances in Geophysics is a highly respected publication in the field of geophysics. Since 1952, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now in its 52nd volume, it contains much material still relevant today--truly an essential publication for researchers in all fields of geophysics.Key features: * Contributions from leading authorities * Informs and updates on all the latest developments in the field

  2. Nanoplasmonics advanced device applications

    CERN Document Server

    Chon, James W M

    2013-01-01

    Focusing on control and manipulation of plasmons at nanometer dimensions, nanoplasmonics combines the strength of electronics and photonics, and is predicted to replace existing integrated circuits and photonic devices. It is one of the fastest growing fields of science, with applications in telecommunication, consumer electronics, data storage, medical diagnostics, and energy.Nanoplasmonics: Advanced Device Applications provides a scientific and technological background of a particular nanoplasmonic application and outlines the progress and challenges of the application. It reviews the latest

  3. Advances in geophysics

    CERN Document Server

    Sato, Haruo

    2013-01-01

    The critically acclaimed serialized review journal for over 50 years, Advances in Geophysics is a highly respected publication in the field of geophysics. Since 1952, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now in its 54th volume, it contains much material still relevant today--truly an essential publication for researchers in all fields of geophysics.Key features: * Contributions from leading authorities * Informs and updates on all the latest developments in the field

  4. Latest Higgs Physics Results with the ATLAS detector

    CERN Document Server

    Orestano, Domizia; The ATLAS collaboration

    2015-01-01

    This report presents the investigations on the recently discovered scalar boson by the ATLAS experiment at the CERN Large Hadron Collider. The latest results fully exploit the data collected during LHC Run 1 to measure the properties of the new boson and within the current sensitivity confirm the identification of this particle with the Higgs boson of the Standard Model.

  5. Latest Higgs Physics results from the ATLAS experiment

    CERN Document Server

    De Groot, Nicolo; The ATLAS collaboration

    2017-01-01

    Since the discovery in 2012, many measurements have been made on the production and prop- erties of the 125 GeV Higgs boson. The latest result from ATLAS will be presented, including recent results from run-1 at 8 TeV and some obtained in run-2 at 13 TeV.

  6. (The latest developments of the physical aspects of electrochemistry)

    Energy Technology Data Exchange (ETDEWEB)

    Liu, S.H.

    1990-09-24

    The author was one of 26 invited lecturers to discuss the latest developments of the physical aspects of electrochemistry. He interacted extensively with other lecturers and many participants from developing countries. He also visited with the Director of the Italian Synchrotron Radiation Source now under construction in Trieste, Italy.

  7. A Demonstration of Advanced Safety Analysis Tools and Methods Applied to Large Break LOCA and Fuel Analysis for PWRs

    Energy Technology Data Exchange (ETDEWEB)

    Szilard, Ronaldo Henriques [Idaho National Laboratory; Smith, Curtis Lee [Idaho National Laboratory; Martineau, Richard Charles [Idaho National Laboratory

    2016-03-01

    The U.S. Nuclear Regulatory Commission (NRC) is currently proposing a rulemaking designated as 10 CFR 50.46c to revise the loss-of-coolant accident (LOCA)/emergency core cooling system acceptance criteria to include the effects of higher burnup on fuel/cladding performance. We propose a demonstration problem of a representative four-loop PWR plant to study the impact of this new rule in the US nuclear fleet. Within the scope of evaluation for the 10 CFR 50.46c rule, aspects of safety, operations, and economics are considered in the industry application demonstration presented in this paper. An advanced safety analysis approach is used, by integrating the probabilistic element with deterministic methods for LOCA analysis, a novel approach to solving these types of multi-physics, multi-scale problems.

  8. Advanced Visualization and Analysis of Climate Data using DV3D and UV-CDAT

    Science.gov (United States)

    Maxwell, T. P.

    2012-12-01

    This paper describes DV3D, a Vistrails package of high-level modules for the Ultra-scale Visualization Climate Data Analysis Tools (UV-CDAT) interactive visual exploration system that enables exploratory analysis of diverse and rich data sets stored in the Earth System Grid Federation (ESGF). DV3D provides user-friendly workflow interfaces for advanced visualization and analysis of climate data at a level appropriate for scientists. The application builds on VTK, an open-source, object-oriented library, for visualization and analysis. DV3D provides the high-level interfaces, tools, and application integrations required to make the analysis and visualization power of VTK readily accessible to users without exposing burdensome details such as actors, cameras, renderers, and transfer functions. It can run as a desktop application or distributed over a set of nodes for hyperwall or distributed visualization applications. DV3D is structured as a set of modules which can be linked to create workflows in Vistrails. Figure 1 displays a typical DV3D workflow as it would appear in the Vistrails workflow builder interface of UV-CDAT and, on the right, the visualization spreadsheet output of the workflow. Each DV3D module encapsulates a complex VTK pipeline with numerous supporting objects. Each visualization module implements a unique interactive 3D display. The integrated Vistrails visualization spreadsheet offers multiple synchronized visualization displays for desktop or hyperwall. The currently available displays include volume renderers, volume slicers, 3D isosurfaces, 3D hovmoller, and various vector plots. The DV3D GUI offers a rich selection of interactive query, browse, navigate, and configure options for all displays. All configuration operations are saved as Vistrails provenance. DV3D's seamless integration with UV-CDAT's climate data management system (CDMS) and other climate data analysis tools provides a wide range of climate data analysis operations, e

  9. Cepstrum Analysis: An Advanced Technique in Vibration Analysis of Defects in Rotating Machinery

    Directory of Open Access Journals (Sweden)

    M. Satyam

    1994-01-01

    Full Text Available Conventional frequency analysis in machinery vibration is not adequate to find out accurately defects in gears, bearings, and blades where sidebands and harmonics are present. Also such an approach is dependent on the transmission path. On the other hand, cepstrum analysis accurately identifies harmonics and sideband families and is a better technique available for fault diagnosis in gears, bearings, and turbine blades of ships and submarines. Cepstrum represents the global power content of a whole family of harmonics and sidebands when more than one family of sidebands are presents at the same time. Also it is insensitive to the transmission path effects since source and transmission path effects are additive and can be separated in cepstrum. The concept, underlying theory and the measurement and analysis involved for using the technique are briefly outlined. Two cases were taken to demonstrate advantage of cepstrum technique over the spectrum analysis. An LP compressor was chosen to study the transmission path effects and a marine gearbox having two sets of sideband families was studied to diagnose the problematic sideband and its severity.

  10. Highway Subsidence Analysis Based on the Advanced InSAR Time Series Analysis Method

    Science.gov (United States)

    Zhang, Qingyun; Zhang, Jingfa; Liu, Guolin; Li, Yongsheng

    2016-08-01

    The synthetic aperture radar (InSAR) measurements have the advantages of all-weather, wide range, high precision on the surface deformation monitoring. Highway as an important index of modern social and economic development, the quality and deformation changes in the process of using have a significant impact in the social development and people's life and property security. In practical applications the InSAR technology should do a variety of error correction analysis. By using a new analysis method – FRAM- SBAS time-series analysis method, to analyze the settlement of highway on Yanzhou area by the ALOS PALSAR datas. Use FRAM- SBAS timing analysis method to obtain the surface timing changes during 2008-09-21 to 2010-07-18 in the Jining area and obtained good results, the Jining area maximum timing settlement is 60mm, the maximum settlement rate reached 30mm/yr. The maximum settlement of the highway section is 53mm, the maximum settlement rate is 32mm/yr. And the settlement of highway worst sections were in severe ground subsidence, thus proving the mining and vehicle load effect on settlement of highway. And it is proved that the timing method on the ground and highway subsidence monitoring is feasible.

  11. RISMC advanced safety analysis working plan: FY2015 - FY2019. Light Water Reactor Sustainability Program

    Energy Technology Data Exchange (ETDEWEB)

    Szilard, Ronaldo H; Smith, Curtis L

    2014-09-01

    In this report, the Advanced Safety Analysis Program (ASAP) objectives and value proposition is described. ASAP focuses on modernization of nuclear power safety analysis (tools, methods and data); implementing state-of-the-art modeling techniques (which include, for example, enabling incorporation of more detailed physics as they become available); taking advantage of modern computing hardware; and combining probabilistic and mechanistic analyses to enable a risk informed safety analysis process. The modernized tools will maintain the current high level of safety in our nuclear power plant fleet, while providing an improved understanding of safety margins and the critical parameters that affect them. Thus, the set of tools will provide information to inform decisions on plant modifications, refurbishments, and surveillance programs, while improving economics. The set of tools will also benefit the design of new reactors, enhancing safety per unit cost of a nuclear plant. As part of the discussion, we have identified three sets of stakeholders, the nuclear industry, the Department of Energy (DOE), and associated oversight organizations. These three groups would benefit from ASAP in different ways. For example, within the DOE complex, the possible applications that are seen include the safety of experimental reactors, facility life extension, safety-by-design in future generation advanced reactors, and managing security for the storage of nuclear material. This report provides information in five areas: (1) A value proposition (“why is this important?”) that will make the case for stakeholder’s use of the ASAP research and development (R&D) products; (2) An identification of likely end users and pathway to adoption of enhanced tools by the end-users; (3) A proposed set of practical and achievable “use case” demonstrations; (4) A proposed plan to address ASAP verification and validation (V&V) needs; and (5) A proposed schedule for the multi-year ASAP.

  12. PREFACE: 14th International Workshop on Advanced Computing and Analysis Techniques in Physics Research (ACAT 2011)

    Science.gov (United States)

    Teodorescu, Liliana; Britton, David; Glover, Nigel; Heinrich, Gudrun; Lauret, Jérôme; Naumann, Axel; Speer, Thomas; Teixeira-Dias, Pedro

    2012-06-01

    ACAT2011 This volume of Journal of Physics: Conference Series is dedicated to scientific contributions presented at the 14th International Workshop on Advanced Computing and Analysis Techniques in Physics Research (ACAT 2011) which took place on 5-7 September 2011 at Brunel University, UK. The workshop series, which began in 1990 in Lyon, France, brings together computer science researchers and practitioners, and researchers from particle physics and related fields in order to explore and confront the boundaries of computing and of automatic data analysis and theoretical calculation techniques. It is a forum for the exchange of ideas among the fields, exploring and promoting cutting-edge computing, data analysis and theoretical calculation techniques in fundamental physics research. This year's edition of the workshop brought together over 100 participants from all over the world. 14 invited speakers presented key topics on computing ecosystems, cloud computing, multivariate data analysis, symbolic and automatic theoretical calculations as well as computing and data analysis challenges in astrophysics, bioinformatics and musicology. Over 80 other talks and posters presented state-of-the art developments in the areas of the workshop's three tracks: Computing Technologies, Data Analysis Algorithms and Tools, and Computational Techniques in Theoretical Physics. Panel and round table discussions on data management and multivariate data analysis uncovered new ideas and collaboration opportunities in the respective areas. This edition of ACAT was generously sponsored by the Science and Technology Facility Council (STFC), the Institute for Particle Physics Phenomenology (IPPP) at Durham University, Brookhaven National Laboratory in the USA and Dell. We would like to thank all the participants of the workshop for the high level of their scientific contributions and for the enthusiastic participation in all its activities which were, ultimately, the key factors in the

  13. Study on the Formats of the Latest Library Strategic Plans Abroad--An Analysis Based on 51 Strategic Planning Texts%国外最新图书馆战略规划体例研究——基于51份战略规划文本的分析

    Institute of Scientific and Technical Information of China (English)

    江洪; 於维樱; 魏慧; 唐美灵

    2012-01-01

    以51个国外最新的战略规划文本为主要依据,采用数理统计的方法对战略规划体例进行宏观分析,并按使用频率对体例进行等级划分,得出必备体例、核心体例、常用体例与备选体例;按内容特点将体例要素归纳为介绍性体例、定位性体例与战略性体例进行深入细化分析,并介绍SWOT分析、绩效评估与风险管理等三类特色体例;总结国外战略规划的优势与特点,结合我国实际给出相应建议,为我国图书馆战略规划文本的编排和撰写提供有意义的参考和借鉴。%Based on 51 latest strategic planning texts abroad, analyzing the format of strategic plans with the method of mathematical statistics, and then classifying the rate of these formats as essential formats, core formats, common formats and alternative formats by their proportion; summarizing these formats as introductive formats, positioning formats and strategic: formats to deeper analysis, and introducing three special formats, including SWOT analysis, performance evaluation and risk management; summarizing the advantages and features of library strategic plans abroad and providing corresponding recommendations combining with Chinese actual conditions , so as to provide meaningful references for the arrangement and writing of library strategic planning texts in China.

  14. The development of leadership outcome-indicators evaluating the contribution of clinical specialists and advanced practitioners to health care: a secondary analysis.

    LENUS (Irish Health Repository)

    Elliott, Naomi

    2014-05-01

    To report a secondary analysis of data collected from the case study phase of a national study of advanced practitioners and to develop leadership outcome-indicators appropriate for advanced practitioners.

  15. Formability Analysis of Diode-Laser-Welded Tailored Blanks of Advanced High-Strength Steel Sheets

    Science.gov (United States)

    Panda, S. K.; Baltazar Hernandez, V. H.; Kuntz, M. L.; Zhou, Y.

    2009-08-01

    Currently, advances due to tailored blanking can be enhanced by the development of new grades of advanced high-strength steels (HSSs), for the further weight reduction and structural improvement of automotive components. In the present work, diode laser welds of three different grades of advanced high-strength dual-phase (DP) steel sheets (with tensile strengths of 980, 800, and 450 MPa) to high-strength low-alloy (HSLA) material were fabricated by applying the proper welding parameters. Formability in terms of Hecker’s limiting dome height (LDH), the strain distribution on the hemispherical dome surface, the weld line movement during deformation, and the load-bearing capacity during the stretch forming of these different laser-welded blanks were compared. Finite element (FE) analysis of the LDH tests of both the parent metals and laser-welded blanks was done using the commercially available software package LS-DYNA (Livermore Software Technology Corporation, Livermore, CA); the results compared well with the experimental data. It was also found that the LDH was not affected by the soft zone or weld zone properties; it decreased, however, with an increase in a nondimensional parameter, the “strength ratio” (SR). The weld line movement during stretch forming is an indication of nonuniform deformation resulting in a decrease in the LDH. In all the dissimilar weldments, fracture took place on the HSLA side, but the fracture location shifted to near the weld line (at the pole) in tailor-welded blanks (TWBs) of a higher strength ratio.

  16. SOARCA Peach Bottom Atomic Power Station Long-Term Station Blackout Uncertainty Analysis: Knowledge Advancement.

    Energy Technology Data Exchange (ETDEWEB)

    Gauntt, Randall O.; Mattie, Patrick D.; Bixler, Nathan E.; Ross, Kyle W.; Cardoni, Jeffrey N; Kalinich, Donald A.; Osborn, Douglas.; Sallaberry, Cedric Jean-Marie; Ghosh, S. Tina

    2014-02-01

    This paper describes the knowledge advancements from the uncertainty analysis for the State-of- the-Art Reactor Consequence Analyses (SOARCA) unmitigated long-term station blackout accident scenario at the Peach Bottom Atomic Power Station. This work assessed key MELCOR and MELCOR Accident Consequence Code System, Version 2 (MACCS2) modeling uncertainties in an integrated fashion to quantify the relative importance of each uncertain input on potential accident progression, radiological releases, and off-site consequences. This quantitative uncertainty analysis provides measures of the effects on consequences, of each of the selected uncertain parameters both individually and in interaction with other parameters. The results measure the model response (e.g., variance in the output) to uncertainty in the selected input. Investigation into the important uncertain parameters in turn yields insights into important phenomena for accident progression and off-site consequences. This uncertainty analysis confirmed the known importance of some parameters, such as failure rate of the Safety Relief Valve in accident progression modeling and the dry deposition velocity in off-site consequence modeling. The analysis also revealed some new insights, such as dependent effect of cesium chemical form for different accident progressions. (auth)

  17. Advance in ERG Analysis: From Peak Time and Amplitude to Frequency, Power, and Energy

    Directory of Open Access Journals (Sweden)

    Mathieu Gauvin

    2014-01-01

    Full Text Available Purpose. To compare time domain (TD: peak time and amplitude analysis of the human photopic electroretinogram (ERG with measures obtained in the frequency domain (Fourier analysis: FA and in the time-frequency domain (continuous (CWT and discrete (DWT wavelet transforms. Methods. Normal ERGs n=40 were analyzed using traditional peak time and amplitude measurements of the a- and b-waves in the TD and descriptors extracted from FA, CWT, and DWT. Selected descriptors were also compared in their ability to monitor the long-term consequences of disease process. Results. Each method extracted relevant information but had distinct limitations (i.e., temporal and frequency resolutions. The DWT offered the best compromise by allowing us to extract more relevant descriptors of the ERG signal at the cost of lesser temporal and frequency resolutions. Follow-ups of disease progression were more prolonged with the DWT (max 29 years compared to 13 with TD. Conclusions. Standardized time domain analysis of retinal function should be complemented with advanced DWT descriptors of the ERG. This method should allow more sensitive/specific quantifications of ERG responses, facilitate follow-up of disease progression, and identify diagnostically significant changes of ERG waveforms that are not resolved when the analysis is only limited to time domain measurements.

  18. From first to latest imaging technology: Revisiting the first mummy investigated with X-ray in 1896 by using dual-source computed tomography

    Directory of Open Access Journals (Sweden)

    Stephanie Zesch

    2016-01-01

    Conclusion: Our results highlight the enormous progress achieved form earliest to latest imaging technology for advanced mummy research using the first human mummy investigated with X-ray. With the application of DSCT, detailed knowledge regarding age at death, sex, diseases, death, and mummification of a child from Ptolemaic Egypt are revealed while considering the temporary rites of body treatment and burial for children.

  19. Technology Alignment and Portfolio Prioritization (TAPP): Advanced Methods in Strategic Analysis, Technology Forecasting and Long Term Planning for Human Exploration and Operations, Advanced Exploration Systems and Advanced Concepts

    Science.gov (United States)

    Funaro, Gregory V.; Alexander, Reginald A.

    2015-01-01

    The Advanced Concepts Office (ACO) at NASA, Marshall Space Flight Center is expanding its current technology assessment methodologies. ACO is developing a framework called TAPP that uses a variety of methods, such as association mining and rule learning from data mining, structure development using a Technological Innovation System (TIS), and social network modeling to measure structural relationships. The role of ACO is to 1) produce a broad spectrum of ideas and alternatives for a variety of NASA's missions, 2) determine mission architecture feasibility and appropriateness to NASA's strategic plans, and 3) define a project in enough detail to establish an initial baseline capable of meeting mission objectives ACO's role supports the decision­-making process associated with the maturation of concepts for traveling through, living in, and understanding space. ACO performs concept studies and technology assessments to determine the degree of alignment between mission objectives and new technologies. The first step in technology assessment is to identify the current technology maturity in terms of a technology readiness level (TRL). The second step is to determine the difficulty associated with advancing a technology from one state to the next state. NASA has used TRLs since 1970 and ACO formalized them in 1995. The DoD, ESA, Oil & Gas, and DoE have adopted TRLs as a means to assess technology maturity. However, "with the emergence of more complex systems and system of systems, it has been increasingly recognized that TRL assessments have limitations, especially when considering [the] integration of complex systems." When performing the second step in a technology assessment, NASA requires that an Advancement Degree of Difficulty (AD2) method be utilized. NASA has used and developed or used a variety of methods to perform this step: Expert Opinion or Delphi Approach, Value Engineering or Value Stream, Analytical Hierarchy Process (AHP), Technique for the Order of

  20. Advanced Residuals Analysis for Determining the Number of PARAFAC Components in Dissolved Organic Matter.

    Science.gov (United States)

    Cuss, Chad W; Guéguen, Céline; Andersson, Per; Porcelli, Don; Maximov, Trofim; Kutscher, Liselott

    2016-02-01

    Parallel factor analysis (PARAFAC) has facilitated an explosion in research connecting the fluorescence properties of dissolved organic matter (DOM) to its functions and biogeochemical cycling in natural and engineered systems. However, the validation of robust PARAFAC models using split-half analysis requires an oft unrealistically large number (hundreds to thousands) of excitation-emission matrices (EEMs), and models with too few components may not adequately describe differences between DOM. This study used self-organizing maps (SOM) and comparing changes in residuals with the effects of adding components to estimate the number of PARAFAC components in DOM from two data sets: MS (110 EEMs from nine leaf leachates and headwaters) and LR (64 EEMs from the Lena River). Clustering by SOM demonstrated that peaks clearly persisted in model residuals after validation by split-half analysis. Plotting the changes to residuals was an effective method for visualizing the removal of fluorophore-like fluorescence caused by increasing the number of PARAFAC components. Extracting additional PARAFAC components via residuals analysis increased the proportion of correctly identified size-fractionated leaf leachates from 56.0 ± 0.8 to 75.2 ± 0.9%, and from 51.7 ± 1.4 to 92.9 ± 0.0% for whole leachates. Model overfitting was assessed by considering the correlations between components, and their distributions amongst samples. Advanced residuals analysis improved the ability of PARAFAC to resolve the variation in DOM fluorescence, and presents an enhanced validation approach for assessing the number of components that can be used to supplement the potentially misleading results of split-half analysis.

  1. Advances in three-dimensional field analysis and evaluation of performance parameters of electrical machines

    Science.gov (United States)

    Sivasubramaniam, Kiruba

    This thesis makes advances in three dimensional finite element analysis of electrical machines and the quantification of their parameters and performance. The principal objectives of the thesis are: (1)the development of a stable and accurate method of nonlinear three-dimensional field computation and application to electrical machinery and devices; and (2)improvement in the accuracy of determination of performance parameters, particularly forces and torque computed from finite elements. Contributions are made in two general areas: a more efficient formulation for three dimensional finite element analysis which saves time and improves accuracy, and new post-processing techniques to calculate flux density values from a given finite element solution. A novel three-dimensional magnetostatic solution based on a modified scalar potential method is implemented. This method has significant advantages over the traditional total scalar, reduced scalar or vector potential methods. The new method is applied to a 3D geometry of an iron core inductor and a permanent magnet motor. The results obtained are compared with those obtained from traditional methods, in terms of accuracy and speed of computation. A technique which has been observed to improve force computation in two dimensional analysis using a local solution of Laplace's equation in the airgap of machines is investigated and a similar method is implemented in the three dimensional analysis of electromagnetic devices. A new integral formulation to improve force calculation from a smoother flux-density profile is also explored and implemented. Comparisons are made and conclusions drawn as to how much improvement is obtained and at what cost. This thesis also demonstrates the use of finite element analysis to analyze torque ripples due to rotor eccentricity in permanent magnet BLDC motors. A new method for analyzing torque harmonics based on data obtained from a time stepping finite element analysis of the machine is

  2. An Advanced Neutronic Analysis Toolkit with Inline Monte Carlo capability for BHTR Analysis

    Energy Technology Data Exchange (ETDEWEB)

    William R. Martin; John C. Lee

    2009-12-30

    Monte Carlo capability has been combined with a production LWR lattice physics code to allow analysis of high temperature gas reactor configurations, accounting for the double heterogeneity due to the TRISO fuel. The Monte Carlo code MCNP5 has been used in conjunction with CPM3, which was the testbench lattice physics code for this project. MCNP5 is used to perform two calculations for the geometry of interest, one with homogenized fuel compacts and the other with heterogeneous fuel compacts, where the TRISO fuel kernels are resolved by MCNP5.

  3. A Review of Failure Analysis Methods for Advanced 3D Microelectronic Packages

    Science.gov (United States)

    Li, Yan; Srinath, Purushotham Kaushik Muthur; Goyal, Deepak

    2016-01-01

    Advanced three dimensional (3D) packaging is a key enabler in driving form factor reduction, performance benefits, and package cost reduction, especially in the fast paced mobility and ultraportable consumer electronics segments. The high level of functional integration and the complex package architecture pose a significant challenge for conventional fault isolation (FI) and failure analysis (FA) methods. Innovative FI/FA tools and techniques are required to tackle the technical and throughput challenges. In this paper, the applications of FI and FA techniques such as Electro Optic Terahertz Pulse Reflectometry, 3D x-ray computed tomography, lock-in thermography, and novel physical sample preparation methods to 3D packages with package on package and stacked die with through silicon via configurations are reviewed, along with the key FI and FA challenges.

  4. Capturing Crime: The Qualitative Analysis of Individual Cases for Advancing Criminological Knowledge.

    Science.gov (United States)

    Wright, Kevin A; Bouffard, Leana A

    2016-02-01

    The qualitative analysis of individual cases has a prominent place in the development of criminological theory, yet progression in the scientific study of crime has largely been viewed as a distinctly quantitative endeavor. In the process, much of the theoretical depth and precision supplied by earlier methods of criminological knowledge production have been sacrificed. The current work argues for a return to our criminological roots by supplementing quantitative analyses with the qualitative inspection of individual cases. We provide a specific example of a literature (i.e., criminal specialization/versatility) that has become increasingly quantitative and could benefit from the use of the proposed approach. We conclude by offering additional areas of research that might be advanced by our framework presented here.

  5. Analysis and synthesis of networked control systems: A survey of recent advances and challenges.

    Science.gov (United States)

    Zhang, Dan; Shi, Peng; Wang, Qing-Guo; Yu, Li

    2017-01-01

    A networked control system (NCS) is a control system which involves a communication network. In NCSs, the continuous-time measurement is usually sampled and quantized before transmission. Then, the measurement is transmitted to the remote controller via the communication channel, during which the signal may be delayed, lost or even sometimes not allowed for transmission due to the communication or energy constraints. In recent years, the modeling, analysis and synthesis of networked control systems (NCSs) have received great attention, which leads to a large number of publications. This paper attempts to present an overview of recent advances and unify them in a framework of network-induced issues such as signal sampling, data quantization, communication delay, packet dropouts, medium access constraints, channel fading and power constraint, and present respective solution approaches to each of these issues. We draw some conclusions and highlight future research directions in end.

  6. The conceptual analysis of MBA and KMP for advanced spent fuel management process

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Sang Yoon; Ko, Won Il; Ha, Jang Ho; Kim, Ho Dong; Koo, Dae Seo [Korea Atomic Energy Research Institute, Taejeon (Korea)

    2002-03-01

    This report describes the concept of dry reprocessing of molten salt which is proposed as nuclear fuel cycle with nuclear proliferation resistance. These basic researches in Japan, U. S., Russia are in progress, and Republic of Korea is performing basic research of metallic conversion fabrication of molten salt of uranium dioxide fuels through nuclear research project. In this report, we have performed conceptual analysis and establishment of MBA and KMP for nuclear material safeguards in order to accomplish metallic conversion research of molten salt of uranium dioxide fuels. This report will contribute to the implementation of nuclear material safeguards of advanced spent fuel management process, and also the usage of basic data of nuclear material safeguards for spent fuel recycling process of native country. 11 refs., 17 figs., 8 tabs. (Author)

  7. Nonlinear approaches in engineering applications advanced analysis of vehicle related technologies

    CERN Document Server

    Dai, Liming

    2016-01-01

    This book looks at the broad field of engineering science through the lens of nonlinear approaches. Examples focus on issues in vehicle technology, including vehicle dynamics, vehicle-road interaction, steering, and control for electric and hybrid vehicles. Also included are discussions on train and tram systems, aerial vehicles, robot-human interaction, and contact and scratch analysis at the micro/nanoscale. Chapters are based on invited contributions from world-class experts in the field who advance the future of engineering by discussing the development of more optimal, accurate, efficient, and cost and energy effective systems. This book is appropriate for researchers, students, and practicing engineers who are interested in the applications of nonlinear approaches to solving engineering and science problems.

  8. TRAC-PF1: an advanced best-estimate computer program for pressurized water reactor analysis

    Energy Technology Data Exchange (ETDEWEB)

    Liles, D.R.; Mahaffy, J.H.

    1984-02-01

    The Transient Reactor Analysis Code (TRAC) is being developed at the Los Alamos National Laboratory to provide advanced best-estimate predictions of postulated accidents in light water reactors. The TRAC-PF1 program provides this capability for pressurized water reactors and for many thermal-hydraulic experimental facilities. The code features either a one-dimensional or a three-dimensional treatment of the pressure vessel and its associated internals; a two-phase, two-fluid nonequilibrium hydrodynamics model with a noncondensable gas field; flow-regime-dependent constitutive equation treatment; optional reflood tracking capability for both bottom flood and falling-film quench fronts; and consistent treatment of entire accident sequences including the generation of consistent initial conditions. This report describes the thermal-hydraulic models and the numerical solution methods used in the code. Detailed programming and user information also are provided.

  9. Advances in intelligent analysis of medical data and decision support systems

    CERN Document Server

    Iantovics, Barna

    2013-01-01

    This volume is a result of the fruitful and vivid discussions during the MedDecSup'2012 International Workshop bringing together a relevant body of knowledge, and new developments in the increasingly important field of medical informatics. This carefully edited book presents new ideas aimed at the development of intelligent processing of various kinds of medical information and the perfection of the contemporary computer systems for medical decision support. The book presents advances of the medical information systems for intelligent archiving, processing, analysis and search-by-content which will improve the quality of the medical services for every patient and of the global healthcare system. The book combines in a synergistic way theoretical developments with the practicability of the approaches developed and presents the last developments and achievements in  medical informatics to a broad range of readers: engineers, mathematicians, physicians, and PhD students.

  10. Preliminary performance analysis of the advanced pulse compression noise radar waveform

    Science.gov (United States)

    Govoni, Mark A.; Moyer, Lee R.

    2012-06-01

    Noise radar systems encounter target fluctuation behavior similar to that of conventional systems. For noise radar systems, however, the fluctuations are not only dictated by target composition and geometry, but also by the non-uniform power envelope of their random transmit signals. This third dependency is of interest and serves as the basis for the preliminary analysis conducted in this manuscript. General conclusions are drawn on the implications of having a random power envelope and the impacts it could have on both the transmit and receive processes. Using an advanced pulse compression noise (APCN) radar waveform as the constituent signal, a computer simulation aids in quantifying potential losses and the impacts they might have on the detection performance of a real radar system.

  11. Advances and pitfalls in the analysis and interpretation of resting-state FMRI data

    Directory of Open Access Journals (Sweden)

    David M Cole

    2010-04-01

    Full Text Available The last 15 years have witnessed a steady increase in the number of resting-state functional neuroimaging studies. The connectivity patterns of multiple functional, distributed, large-scale networks of brain dynamics have been recognised for their potential as useful tools in the domain of systems and other neurosciences. The application of functional connectivity methods to areas such as cognitive psychology, clinical diagnosis and treatment progression has yielded promising preliminary results, but is yet to be fully realised. This is due, in part, to an array of methodological and interpretative issues that remain to be resolved. We here present a review of the methods most commonly applied in this rapidly advancing field, such as seed-based correlation analysis and independent component analysis, along with examples of their use at the individual subject and group analysis levels and a discussion of practical and theoretical issues arising from this data ‘explosion’. We describe the similarities and differences across these varied statistical approaches to processing resting-state FMRI signals, and conclude that further technical optimisation and experimental refinement is required in order to fully delineate and characterise the gross complexity of the human neural functional architecture.

  12. 动力定位系统的最新技术进展分析%Analysis of Recent Technology Advancement in Dynamic Positioning System

    Institute of Scientific and Technical Information of China (English)

    史斌杰; 吴喆莹

    2011-01-01

    随着深海技术的不断发展和推进,动力定位系统的应用越来越广泛,已成为船舶自动化技术中的一个热点问题。从动力定位系统的3个组成部分——位置测量系统、控制系统和推力系统分析了动力定位系统的现状和相关技术的最新进展。%With the development and advancement of deep-sea technologies, dynamic positioning (DP) system has wider and wider applications and has become a hot issue of marine automation technology. This paper analyzes the current status and latest advancement of DP system from its three components: position measurement systems, control systems and thrust system.

  13. Advanced computational electromagnetic methods and applications

    CERN Document Server

    Li, Wenxing; Elsherbeni, Atef; Rahmat-Samii, Yahya

    2015-01-01

    This new resource covers the latest developments in computational electromagnetic methods, with emphasis on cutting-edge applications. This book is designed to extend existing literature to the latest development in computational electromagnetic methods, which are of interest to readers in both academic and industrial areas. The topics include advanced techniques in MoM, FEM and FDTD, spectral domain method, GPU and Phi hardware acceleration, metamaterials, frequency and time domain integral equations, and statistics methods in bio-electromagnetics.

  14. Advanced alpha spectrum analysis based on the fitting and covariance analysis of dependent variables

    Science.gov (United States)

    Ihantola, S.; Pelikan, A.; Pöllänen, R.; Toivonen, H.

    2011-11-01

    The correct handling of statistical uncertainties is crucial especially when unfolding alpha spectra that contain a low number of counts or overlapping peaks from different nuclides. For this purpose, we have developed a new spectrum analysis software package called ADAM, which performs a full covariance calculus for alpha-particle emitting radionuclides. By analyzing a large number of simulated and measured spectra, the program was proved to give unbiased peak areas and statistically correct uncertainty limits. This applies regardless of the peak areas and the number of unknown parameters during the fitting. In addition, ADAM performs reliable deconvolution for multiplets, which opens the way for the determination of isotope ratios, such as 239Pu/240Pu.

  15. PREFACE: 15th International Workshop on Advanced Computing and Analysis Techniques in Physics Research (ACAT2013)

    Science.gov (United States)

    Wang, Jianxiong

    2014-06-01

    This volume of Journal of Physics: Conference Series is dedicated to scientific contributions presented at the 15th International Workshop on Advanced Computing and Analysis Techniques in Physics Research (ACAT 2013) which took place on 16-21 May 2013 at the Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China. The workshop series brings together computer science researchers and practitioners, and researchers from particle physics and related fields to explore and confront the boundaries of computing and of automatic data analysis and theoretical calculation techniques. This year's edition of the workshop brought together over 120 participants from all over the world. 18 invited speakers presented key topics on the universe in computer, Computing in Earth Sciences, multivariate data analysis, automated computation in Quantum Field Theory as well as computing and data analysis challenges in many fields. Over 70 other talks and posters presented state-of-the-art developments in the areas of the workshop's three tracks: Computing Technologies, Data Analysis Algorithms and Tools, and Computational Techniques in Theoretical Physics. The round table discussions on open-source, knowledge sharing and scientific collaboration stimulate us to think over the issue in the respective areas. ACAT 2013 was generously sponsored by the Chinese Academy of Sciences (CAS), National Natural Science Foundation of China (NFSC), Brookhaven National Laboratory in the USA (BNL), Peking University (PKU), Theoretical Physics Cernter for Science facilities of CAS (TPCSF-CAS) and Sugon. We would like to thank all the participants for their scientific contributions and for the en- thusiastic participation in all its activities of the workshop. Further information on ACAT 2013 can be found at http://acat2013.ihep.ac.cn. Professor Jianxiong Wang Institute of High Energy Physics Chinese Academy of Science Details of committees and sponsors are available in the PDF

  16. Supersymmetry searches with ATLAS: overview and latest results

    CERN Document Server

    CERN. Geneva

    2013-01-01

    Despite the absence of experimental evidence, weak scale supersymmetry remains one of the best motivated and studied Standard Model extensions. The ATLAS experiment searches for signs of supersymmetry in a large variety of signatures involving events with abnormal production of missing transverse momentum, jets, leptons, photons, third generation fermions, gauge bosons or massive long-lived particles. The talk presents the latest results obtained in these searches.

  17. Latest Trends in Web Information Retrieval and in SEO Factors

    Directory of Open Access Journals (Sweden)

    Carlos Gonzalo

    2015-07-01

    Full Text Available Latest trends in web information retrieval and in  SEO factors, increasingly focused on signals from users as: profile of who performs the search and the interpretation of user intent. The objective of search engines is twofold: focusing at the maximum in the users and make ever less predictable the composition of the search engine result page (SERP , and  combating spam.

  18. Latest news on SUSY from the ATLAS experiment

    CERN Document Server

    CERN. Geneva

    2016-01-01

    Despite the absence of experimental evidence, weak scale supersymmetry remains one of the best motivated and studied Standard Model extensions. This talk reports the latest ATLAS results for searches for supersymmetric (SUSY) particles, obtained with 13 to 18 fb-1 of 13 TeV data. Weak and strong production in both R-Parity conserving and R-Parity violating SUSY scenarios are considered. The searches involved final states including jets, missing transverse momentum, light leptons, taus or photons.

  19. mkt607 all week discussions latest 2015 [ all 16 discussions

    OpenAIRE

    Laynebaril

    2017-01-01

    mkt607 all week discussions latest 2015 [ all 16 discussions] Click Link Below To Buy:   http://hwcampus.com/shop/mkt607-all-week-discussions/   week 1   What are the components of a common marketing plan? Why is it important have a strategic marketing plan? How does the type of product or service affect the marketing strategy? Provide an example.       diss 2 What are the aspects of marketing management? How has the marketing management proc...

  20. A Bayesian analysis of rare B decays with advanced Monte Carlo methods

    Energy Technology Data Exchange (ETDEWEB)

    Beaujean, Frederik

    2012-11-12

    Searching for new physics in rare B meson decays governed by b {yields} s transitions, we perform a model-independent global fit of the short-distance couplings C{sub 7}, C{sub 9}, and C{sub 10} of the {Delta}B=1 effective field theory. We assume the standard-model set of b {yields} s{gamma} and b {yields} sl{sup +}l{sup -} operators with real-valued C{sub i}. A total of 59 measurements by the experiments BaBar, Belle, CDF, CLEO, and LHCb of observables in B{yields}K{sup *}{gamma}, B{yields}K{sup (*)}l{sup +}l{sup -}, and B{sub s}{yields}{mu}{sup +}{mu}{sup -} decays are used in the fit. Our analysis is the first of its kind to harness the full power of the Bayesian approach to probability theory. All main sources of theory uncertainty explicitly enter the fit in the form of nuisance parameters. We make optimal use of the experimental information to simultaneously constrain theWilson coefficients as well as hadronic form factors - the dominant theory uncertainty. Generating samples from the posterior probability distribution to compute marginal distributions and predict observables by uncertainty propagation is a formidable numerical challenge for two reasons. First, the posterior has multiple well separated maxima and degeneracies. Second, the computation of the theory predictions is very time consuming. A single posterior evaluation requires O(1s), and a few million evaluations are needed. Population Monte Carlo (PMC) provides a solution to both issues; a mixture density is iteratively adapted to the posterior, and samples are drawn in a massively parallel way using importance sampling. The major shortcoming of PMC is the need for cogent knowledge of the posterior at the initial stage. In an effort towards a general black-box Monte Carlo sampling algorithm, we present a new method to extract the necessary information in a reliable and automatic manner from Markov chains with the help of hierarchical clustering. Exploiting the latest 2012 measurements, the fit

  1. 基于最新癌痛治疗指南分析住院患者癌痛用药规范性%Analysis of Drug Use Normalization in Inpatients with Cancer Pain Based on the Latest Cancer Pain Treat-ment Guidelines

    Institute of Scientific and Technical Information of China (English)

    邵燕; 李欣荣

    2015-01-01

    Objective:To investigate the therapeutic medication for inpatients with cancer pain, and compare with the latest cancer treatment guidelines to improve the rational drug use. Methods:By a retrospective study, the medical record analysis for the inpatients with cancer from October to December in 2014 was performed, and the incidence of pain and the therapeutic medication were investiga-ted and the rationality of drug use was evaluated based on the latest cancer pain treatment guidelines. Results:The incidence of cancer pain was 25. 46% of 774 cases with new cancer, and 76. 58% of the patients with cancer pain were treated with analgesic drugs. In ac-cordance with the guidelines for the treatment scheme, there was no significant difference between the Opioid-Naive group ( guide group 1) and the Opioids-Tolerant group (guide group 2) in the combination therapy, while there was significant difference in the drug selec-tion and the time of administration. In the guide group 1 the proportion of oxywdone controlled-release tablets was signiticantly higher than that in the guide group 2, the ratio of taking the medicine on time in the guide group 1 was also higher than that in the guide group 2. Both groups showed difference from the guidelines in the pain assessment and titration and specific analgesic drug use. Conclusion:The findings indicate the difference between the pain treatment and the guidelines in therapeutic medication of cancer pain, and the propaganda and education of relevant knowledge should be strengthened to promote the treatment standard.%目的::调查住院患者癌痛用药情况,并与最新癌痛治疗指南进行对比,提高癌痛用药规范性。方法:采用回顾性调查方法,我院分析2014年10~12月住院癌症患者病历,调查患者疼痛发生率、镇痛药物使用情况,基于最新癌痛治疗指南对癌痛治疗药物评价合理性。结果:774例癌症患者中新发癌症的癌痛发生率为25.46%

  2. The InfraRed Imaging Spectrograph (IRIS) for TMT: latest science cases and simulations

    CERN Document Server

    Wright, Shelley A; Do, Tuan; Marshall, Daniel; Larkin, James E; Moore, Anna M; Adamkovics, Mate; Andersen, David; Armus, Lee; Barth, Aaron; Cote, Patrick; Cooke, Jeff; Chisholm, Eric M; Davidge, Timothy; Dunn, Jennifer S; Dumas, Christophe; Ellerbroeck, Brent L; Ghez, Andrea M; Hao, Lei; Hayano, Yutaka; Liu, Michael; Lopez-Rodriguez, Enrique; Lu, Jessica R; Mao, Shude; Marois, Christian; Pandey, Shashi B; Philips, Andrew C; Schoeck, Matthias; Subramaniam, Annapurni; Subramanian, Smitha; Suzuki, Ryuji; Tan, Jonathan C; Terai, Tsuyoshi; Treu, Tommaso; Simard, Luc; Weiss, Jason L; Wincensten, James; Wong, Michael; Zhang, Kai

    2016-01-01

    The Thirty Meter Telescope (TMT) first light instrument IRIS (Infrared Imaging Spectrograph) will complete its preliminary design phase in 2016. The IRIS instrument design includes a near-infrared (0.85 - 2.4 micron) integral field spectrograph (IFS) and imager that are able to conduct simultaneous diffraction-limited observations behind the advanced adaptive optics system NFIRAOS. The IRIS science cases have continued to be developed and new science studies have been investigated to aid in technical performance and design requirements. In this development phase, the IRIS science team has paid particular attention to the selection of filters, gratings, sensitivities of the entire system, and science cases that will benefit from the parallel mode of the IFS and imaging camera. We present new science cases for IRIS using the latest end-to-end data simulator on the following topics: Solar System bodies, the Galactic center, active galactic nuclei (AGN), and distant gravitationally-lensed galaxies. We then briefl...

  3. Malaria Vaccine Adjuvants: Latest Update and Challenges in Preclinical and Clinical Research

    Directory of Open Access Journals (Sweden)

    Elena Mata

    2013-01-01

    Full Text Available There is no malaria vaccine currently available, and the most advanced candidate has recently reported a modest 30% efficacy against clinical malaria. Although many efforts have been dedicated to achieve this goal, the research was mainly directed to identify antigenic targets. Nevertheless, the latest progresses on understanding how immune system works and the data recovered from vaccination studies have conferred to the vaccine formulation its deserved relevance. Additionally to the antigen nature, the manner in which it is presented (delivery adjuvants as well as the immunostimulatory effect of the formulation components (immunostimulants modulates the immune response elicited. Protective immunity against malaria requires the induction of humoral, antibody-dependent cellular inhibition (ADCI and effector and memory cell responses. This review summarizes the status of adjuvants that have been or are being employed in the malaria vaccine development, focusing on the pharmaceutical and immunological aspects, as well as on their immunization outcomings at clinical and preclinical stages.

  4. [Advances in the experimental analysis of behavior: issues of choice behavior, comparative cognition, and human language].

    Science.gov (United States)

    Sakagami, T; Yamamoto, J; Jitsumori, M

    1994-12-01

    As the opportunity to contact with related areas has increased, the study of of the experimental analysis of behavior has experienced revolutionary changes. Some of the most active and important areas-studies of choice, comparative cognition, and human language--are reviewed to acquaint readers. Studies of CHOICE have linked to the molar theories of behavioral economics and behavioral ecology, which promoted research of choice by animals under uncertainty conditions. Further approach has been made to integrate the molar and molecular analyses on the basis of the ideas of behavior dynamics. COMPARATIVE COGNITION is a part of a larger field including cognitive science, behavioral neuroscience, and biological science. Recent developments, aided with a comparative perspective, made significant contributions to our understanding of the phylogeny and ontogeny of cognition. Advances in analysis of human behavior provided tools to study behavioral aspects of semantics, syntax, and pragmatics of HUMAN LANGUAGE. Using the paradigm of stimulus equivalence, the emergence of stimulus relations, stimulus-stimulus networks, hierarchical structure of verbal behavior, and other language-related behaviors have been investigated.

  5. Optimizing spinning time-domain gravitational waveforms for Advanced LIGO data analysis

    CERN Document Server

    Devine, Caleb; McWilliams, Sean T

    2016-01-01

    The Spinning Effective One Body-Numerical Relativity (SEOBNR) series of gravitational wave approximants are among the best available for Advanced LIGO data analysis. Unfortunately, SEOBNR codes as they currently exist within LALSuite are generally too slow to be directly useful for standard Markov-Chain Monte Carlo-based parameter estimation (PE). Reduced-Order Models (ROMs) of SEOBNR have been developed for this purpose, but there is no known way to make ROMs of the full eight-dimensional intrinsic parameter space more efficient for PE than the SEOBNR codes directly. So as a proof of principle, we have sped up the original LALSuite SEOBNRv2 approximant code, which models waveforms from aligned-spin systems, by about 280x. Our optimized code shortens the timescale for conducting PE with this approximant to months, assuming a purely serial analysis, so that even modest parallelization combined with our optimized code will make running the full PE pipeline with SEOBNR codes directly a realistic possibility. A n...

  6. Recent advances in the analysis of therapeutic proteins by capillary and microchip electrophoresis.

    Science.gov (United States)

    Creamer, Jessica S; Oborny, Nathan J; Lunte, Susan M

    2014-07-01

    The development of therapeutic proteins and peptides is an expensive and time-intensive process. Biologics, which have become a multi-billion dollar industry, are chemically complex products that require constant observation during each stage of development and production. Post-translational modifications along with chemical and physical degradation from oxidation, deamidation, and aggregation, lead to high levels of heterogeneity that affect drug quality and efficacy. The various separation modes of capillary electrophoresis (CE) are commonly utilized to perform quality control and assess protein heterogeneity. This review attempts to highlight the most recent developments and applications of CE separation techniques for the characterization of protein and peptide therapeutics by focusing on papers accepted for publication in the in the two-year period between January 2012 and December 2013. The separation principles and technological advances of CE, capillary gel electrophoresis, capillary isoelectric focusing, capillary electrochromatography and CE-mass spectrometry are discussed, along with exciting new applications of these techniques to relevant pharmaceutical issues. Also included is a small selection of papers on microchip electrophoresis to show the direction this field is moving with regards to the development of inexpensive and portable analysis systems for on-site, high-throughput analysis.

  7. Recent advances in inorganic materials for LDI-MS analysis of small molecules.

    Science.gov (United States)

    Shi, C Y; Deng, C H

    2016-05-10

    In this review, various inorganic materials were summarized for the analysis of small molecules by laser desorption/ionization mass spectrometry (LDI-MS). Due to its tremendous advantages, such as simplicity, high speed, high throughput, small analyte volumes and tolerance towards salts, LDI-MS has been widely used in various analytes. During the ionization process, a suitable agent is required to assist the ionization, such as an appropriate matrix for matrix assisted laser desorption/ionization mass spectrometry (MALDI-MS). However, it is normally difficult to analyze small molecules with the MALDI technique because conventional organic matrices may produce matrix-related peaks in the low molecular-weight region, which limits the detection of small molecules (m/z molecules. These inorganic materials can transfer energy and improve the ionization efficiency of analytes. In addition, functionalized inorganic materials can act as both an adsorbent and an agent in the enrichment and ionization of small molecules. In this review, we mainly focus on present advances in inorganic materials for the LDI-MS analysis of small molecules in the last five years, which contains the synthetic protocols of novel inorganic materials and the detailed results achieved by inorganic materials. On the other hand, this review also summarizes the application of inorganic materials as adsorbents in the selective enrichment of small molecules, which provides a new field for the application of inorganic materials.

  8. Mission analysis and performance comparison for an Advanced Solar Photon Thruster

    Science.gov (United States)

    Dachwald, Bernd; Wurm, Patrick

    2011-12-01

    The so-called "compound solar sail", also known as "Solar Photon Thruster" (SPT), is a design concept, for which the two basic functions of the solar sail, namely light collection and thrust direction, are uncoupled. In this paper, we introduce a novel SPT concept, termed the Advanced Solar Photon Thruster (ASPT), which does not suffer from the simplified assumptions that have been made for the analysis of compound solar sails in previous studies. After having presented the equations that describe the force on the ASPT and after having performed a detailed design analysis, the performance of the ASPT with respect to the conventional flat solar sail (FSS) is investigated for three interplanetary mission scenarios: an Earth-Venus rendezvous, where the solar sail has to spiral towards the Sun, an Earth-Mars rendezvous, where the solar sail has to spiral away from the Sun, and an Earth-NEA rendezvous (to near-Earth asteroid 1996FG3), where a large change in orbital eccentricity is required. The investigated solar sails have realistic near-term characteristic accelerations between 0.1 and 0.2 mm/s 2. Our results show that an SPT is not superior to the flat solar sail unless very idealistic assumptions are made.

  9. Advances in the analysis of isothermal titration calorimetry data for ligand-DNA interactions.

    Science.gov (United States)

    Buurma, Niklaas J; Haq, Ihtshamul

    2007-06-01

    Isothermal titration calorimetry (ITC) is a well established technique for the study of biological interactions. The strength of ITC is that it directly measures enthalpy changes associated with interactions. Experiments can also yield binding isotherms allowing quantification of equilibrium binding constants, hence an almost complete thermodynamic profile can be established. Principles and application of ITC have been well documented over recent years, experimentally the technique is simple to use and in ideal scenarios data analysis is trivial. However, ITC experiments can be designed such that previously inaccessible parameters can be evaluated. We outline some of these advances, including (1) exploiting different experimental conditions; (2) low affinity systems; (3) high affinity systems and displacement assays. In addition we ask the question: What if data cannot be fit using the fitting functions incorporated in the data-analysis software that came with your ITC? Examples where such data might be generated include systems following non 1:n binding patterns and systems where binding is coupled to other events such as ligand dissociation. Models dealing with such data are now appearing in literature and we summarise examples relevant for the study of ligand-DNA interactions.

  10. Advanced spatio-temporal filtering techniques for photogrammetric image sequence analysis in civil engineering material testing

    Science.gov (United States)

    Liebold, F.; Maas, H.-G.

    2016-01-01

    The paper shows advanced spatial, temporal and spatio-temporal filtering techniques which may be used to reduce noise effects in photogrammetric image sequence analysis tasks and tools. As a practical example, the techniques are validated in a photogrammetric spatio-temporal crack detection and analysis tool applied in load tests in civil engineering material testing. The load test technique is based on monocular image sequences of a test object under varying load conditions. The first image of a sequence is defined as a reference image under zero load, wherein interest points are determined and connected in a triangular irregular network structure. For each epoch, these triangles are compared to the reference image triangles to search for deformations. The result of the feature point tracking and triangle comparison process is a spatio-temporally resolved strain value field, wherein cracks can be detected, located and measured via local discrepancies. The strains can be visualized as a color-coded map. In order to improve the measuring system and to reduce noise, the strain values of each triangle must be treated in a filtering process. The paper shows the results of various filter techniques in the spatial and in the temporal domain as well as spatio-temporal filtering techniques applied to these data. The best results were obtained by a bilateral filter in the spatial domain and by a spatio-temporal EOF (empirical orthogonal function) filtering technique.

  11. Optimizing spinning time-domain gravitational waveforms for advanced LIGO data analysis

    Science.gov (United States)

    Devine, Caleb; Etienne, Zachariah B.; McWilliams, Sean T.

    2016-06-01

    The spinning effective-one-body-numerical relativity (SEOBNR) series of gravitational wave approximants are among the best available for advanced LIGO data analysis. Unfortunately, SEOBNR codes as they currently exist within LALSuite are generally too slow to be directly useful for standard Markov-chain Monte Carlo-based parameter estimation (PE). Reduced-order models (ROMs) of SEOBNR have been developed for this purpose, but there is no known way to make ROMs of the full eight-dimensional intrinsic parameter space more efficient for PE than the SEOBNR codes directly. So as a proof of principle, we have sped up the original LALSuite SEOBNRv2 approximant code, which models waveforms from aligned-spin systems, by nearly 300x. Our optimized code shortens the timescale for conducting PE with this approximant to months, assuming a purely serial analysis, so that even modest parallelization combined with our optimized code will make running the full PE pipeline with SEOBNR codes directly a realistic possibility. A number of our SEOBNRv2 optimizations have already been applied to SEOBNRv3, a new approximant capable of modeling sources with all eight (precessing) intrinsic degrees of freedom. We anticipate that once all of our optimizations have been applied to SEOBNRv3, a similar speed-up may be achieved.

  12. Integration of Advanced Probabilistic Analysis Techniques with Multi-Physics Models

    Energy Technology Data Exchange (ETDEWEB)

    Cetiner, Mustafa Sacit; none,; Flanagan, George F. [ORNL; Poore III, Willis P. [ORNL; Muhlheim, Michael David [ORNL

    2014-07-30

    An integrated simulation platform that couples probabilistic analysis-based tools with model-based simulation tools can provide valuable insights for reactive and proactive responses to plant operating conditions. The objective of this work is to demonstrate the benefits of a partial implementation of the Small Modular Reactor (SMR) Probabilistic Risk Assessment (PRA) Detailed Framework Specification through the coupling of advanced PRA capabilities and accurate multi-physics plant models. Coupling a probabilistic model with a multi-physics model will aid in design, operations, and safety by providing a more accurate understanding of plant behavior. This represents the first attempt at actually integrating these two types of analyses for a control system used for operations, on a faster than real-time basis. This report documents the development of the basic communication capability to exchange data with the probabilistic model using Reliability Workbench (RWB) and the multi-physics model using Dymola. The communication pathways from injecting a fault (i.e., failing a component) to the probabilistic and multi-physics models were successfully completed. This first version was tested with prototypic models represented in both RWB and Modelica. First, a simple event tree/fault tree (ET/FT) model was created to develop the software code to implement the communication capabilities between the dynamic-link library (dll) and RWB. A program, written in C#, successfully communicates faults to the probabilistic model through the dll. A systems model of the Advanced Liquid-Metal Reactor–Power Reactor Inherently Safe Module (ALMR-PRISM) design developed under another DOE project was upgraded using Dymola to include proper interfaces to allow data exchange with the control application (ConApp). A program, written in C+, successfully communicates faults to the multi-physics model. The results of the example simulation were successfully plotted.

  13. 2nd International Afro-European Conference for Industrial Advancement

    CERN Document Server

    Wegrzyn-Wolska, Katarzyna; Hassanien, Aboul; Snasel, Vaclav; Alimi, Adel

    2016-01-01

    This volume contains papers presented at the 2nd International Afro-European Conference for Industrial Advancement -- AECIA 2015. The conference aimed at bringing together the foremost experts and excellent young researchers from Africa, Europe and the rest of the world to disseminate the latest results from various fields of engineering, information, and communication technologies. The topics, discussed at the conference, covered a broad range of domains spanning from ICT and engineering to prediction, modeling, and analysis of complex systems. The 2015 edition of AECIA featured a distinguished special track on prediction, modeling and analysis of complex systems -- Nostradamus, and special sessions on Advances in Image Processing and Colorization and Data Processing, Protocols, and Applications in Wireless Sensor Networks.

  14. Advances in Propulsive Bionic Feet and Their Actuation Principles

    Directory of Open Access Journals (Sweden)

    Pierre Cherelle

    2014-07-01

    Full Text Available In the past decades, researchers have deeply studied pathological and nonpathological gait to understand the human ankle function during walking. These efforts resulted in the development of new lower limb prosthetic devices aiming at raising the 3C-level (control, comfort, and cosmetics of amputees. Thanks to the technological advances in engineering and mechatronics, challenges in the field of prosthetics have become an important source of interest for roboticists. Currently, most of the bionic feet are still on a research level but show promising results and a preview of tomorrow's commercial prosthetic devices. In this paper, the authors present the current state-of-the-art and the latest advances in propulsive bionic feet with its actuation principles. The context of this review study is outlined followed by a brief description of the basics in human biomechanics and criteria for new prosthetic designs. A new categorization based on the actuation principle of propulsive ankle-foot prostheses is proposed. Based on simulations, the general principles and benefits of each actuation method are explained. The corresponding latest advances in propulsive bionic feet are presented together with their main characteristics and scientific outcomes. The authors also propose to the reader a comparison analysis of the presented devices with a discussion of the general tendencies in new prosthetic feet.

  15. Latest Pleistocene and Holocene glacial events in the Colonia valley, Northern Patagonia Icefield, southern Chile

    Science.gov (United States)

    Nimick, David A.; Mcgrath, Daniel; Mahan, Shannon; Friesen, Beverly A.; Leidich, Jonathan

    2016-01-01

    The Northern Patagonia Icefield (NPI) is the primary glaciated terrain worldwide at its latitude (46.5–47.5°S), and constraining its glacial history provides unique information for reconstructing Southern Hemisphere paleoclimate. The Colonia Glacier is the largest outlet glacier draining the eastern NPI. Ages were determined using dendrochronology, lichenometry, radiocarbon, cosmogenic 10Be and optically stimulated luminescence. Dated moraines in the Colonia valley defined advances at 13.2 ± 0.95, 11.0 ± 0.47 and 4.96 ± 0.21 ka, with the last being the first constraint on the onset of Neoglaciation for the eastern NPI from a directly dated landform. Dating in the tributary Cachet valley, which contains an ice-dammed lake during periods of Colonia Glacier expansion, defined an advance at ca. 2.95 ± 0.21 ka, periods of advancement at 810 ± 49 cal a BP and 245 ± 13 cal a BP, and retreat during the intervening periods. Recent Colonia Glacier thinning, which began in the late 1800s, opened a lower-elevation outlet channel for Lago Cachet Dos in ca. 1960. Our data provide the most comprehensive set of Latest Pleistocene and Holocene ages for a single NPI outlet glacier and expand previously developed NPI glacial chronologies.

  16. Current advances in molecular, biochemical, and computational modeling analysis of microalgal triacylglycerol biosynthesis.

    Science.gov (United States)

    Lenka, Sangram K; Carbonaro, Nicole; Park, Rudolph; Miller, Stephen M; Thorpe, Ian; Li, Yantao

    2016-01-01

    Triacylglycerols (TAGs) are highly reduced energy storage molecules ideal for biodiesel production. Microalgal TAG biosynthesis has been studied extensively in recent years, both at the molecular level and systems level through experimental studies and computational modeling. However, discussions of the strategies and products of the experimental and modeling approaches are rarely integrated and summarized together in a way that promotes collaboration among modelers and biologists in this field. In this review, we outline advances toward understanding the cellular and molecular factors regulating TAG biosynthesis in unicellular microalgae with an emphasis on recent studies on rate-limiting steps in fatty acid and TAG synthesis, while also highlighting new insights obtained from the integration of multi-omics datasets with mathematical models. Computational methodologies such as kinetic modeling, metabolic flux analysis, and new variants of flux balance analysis are explained in detail. We discuss how these methods have been used to simulate algae growth and lipid metabolism in response to changing culture conditions and how they have been used in conjunction with experimental validations. Since emerging evidence indicates that TAG synthesis in microalgae operates through coordinated crosstalk between multiple pathways in diverse subcellular destinations including the endoplasmic reticulum and plastids, we discuss new experimental studies and models that incorporate these findings for discovering key regulatory checkpoints. Finally, we describe tools for genetic manipulation of microalgae and their potential for future rational algal strain design. This comprehensive review explores the potential synergistic impact of pathway analysis, computational approaches, and molecular genetic manipulation strategies on improving TAG production in microalgae.

  17. Adjuvant therapy for locally advanced renal cell cancer: A systematic review with meta-analysis

    Directory of Open Access Journals (Sweden)

    Lima Carmen SP

    2011-03-01

    Full Text Available Abstract Background Many adjuvant trials have been undertaken in an attempt to reduce the risk of recurrence among patients who undergo surgical resection for locally advanced renal cancer. However, no clear benefit has been identified to date. This systematic review was conducted to examine the exact role of adjuvant therapy in renal cancer setting. Methods Randomized controlled trials were searched comparing adjuvant therapy (chemotherapy, vaccine, immunotherapy, biochemotherapy versus no active treatment after surgery among renal cell cancer patients. Outcomes were overall survival (OS, disease-free survival (DFS, and severe toxicities. Risk ratios (RR, hazard ratios (HR and 95% confidence intervals were calculated using a fixed-effects meta-analysis. Heterogeneity was measured by I2. Different strategies of adjuvant treatment were evaluated separately. Results Ten studies (2,609 patients were included. Adjuvant therapy provided no benefits in terms of OS (HR 1.07; 95%CI 0.89 to 1.28; P = 0.48 I2 = 0% or DFS (HR 1.03; 95%CI 0.87 to 1.21; P = 0.77 I2 = 15% when compared to no treatment. No subgroup analysis (immunotherapy, vaccines, biochemotherapy and hormone therapy had relevant results. Toxicity evaluation depicted a significantly higher frequency of serious adverse events in the adjuvant group. Conclusions This analysis provided no support for the hypothesis that the agents studied provide any clinical benefit for renal cancer patients although they increase the risk of toxic effects. Randomized trials are underway to test targeted therapies, which might open a new therapeutic frontier. Until these trials yield results, no adjuvant therapy can be recommended for patients who undergo surgical resection for renal cell cancer.

  18. Lorentz Invariance Violation: the Latest Fermi Results and the GRB-AGN Complementarity

    Science.gov (United States)

    Bolmont, J.; Vasileiou, V.; Jacholkowska, A.; Piron, F.; Couturier, C.; Granot, J.; Stecker, F. W.; Cohen-Tanugi, J.; Longo, F.

    2013-01-01

    Because they are bright and distant, Gamma-ray Bursts (GRBs) have been used for more than a decade to test propagation of photons and to constrain relevant Quantum Gravity (QG) models in which the velocity of photons in vacuum can depend on their energy. With its unprecedented sensitivity and energy coverage, the Fermi satellite has provided the most constraining results on the QG energy scale so far. In this talk, the latest results obtained from the analysis of four bright GRBs observed by the Large Area Telescope will be reviewed. These robust results, cross-checked using three different analysis techniques set the limit on QG energy scale at E(sub QG,1) greater than 7.6 times the Planck energy for linear dispersion and E(sub QG,2) greater than 1.3 x 10(exp 11) gigaelectron volts for quadratic dispersion (95% CL). After describing the data and the analysis techniques in use, results will be discussed and confronted to latest constraints obtained with Active Galactic Nuclei.

  19. Differences in economic development in rural regions of advanced countries: an overview and critical analysis of theories

    NARCIS (Netherlands)

    Terluin, I.J.

    2003-01-01

    This article provides an overview and critical analysis of theories on economic development in rural regions in advanced countries. For this purpose, we have consulted literature in regional economics and the multidisciplinary field of rural studies. In order to analyse to which extent these theorie

  20. An Advanced LC–MS/MS Platform for the Analysis of Specialized Pro-Resolving Lipid Mediators

    NARCIS (Netherlands)

    Jónasdóttir, H.S.; Ioan-Facsinay, A.; Kwekkeboom, J.; Brouwers, H.; Zuurmond, A.M.; Toes, R.; Deelder, A.M.; Giera, M.

    2014-01-01

    Here we present an advanced platform for the analysis of specialized pro-resolving mediators (SPM), including a set of pro-inflammatory lipids and respective biochemical pathway markers. The platform is characterized by a largely simplified sample preparation protocol, employing methanol protein-pre

  1. Application of holographic interferometry for analysis of the dynamic and modal characteristics of an advanced exotic metal airfoil structure

    Science.gov (United States)

    Fein, Howard

    1999-03-01

    Holographic Interferometry has been successfully employed to characterize the materials and behavior of diverse types of structures under stress. Specialized variations of this technology have also been applied to define dynamic and vibration related structural behavior. Such applications of holographic technique offer some of the most effective methods of modal and dynamic analysis available. Real-time dynamic testing of the modal and mechanical behavior of aerodynamic control and airfoil structures for advanced aircraft has always required advanced instrumentation for data collection in either actual flight test or wind-tunnel simulations. Advanced optical holography techniques are alternate methods which result in actual full-field behavioral data on the ground in a noninvasive environment. These methods offer significant insight in both the development and subsequent operational test and modeling of advanced exotic metal control structures and their integration with total vehicle system dynamics. Structures and materials can be analyzed with very low amplitude excitation and the resultant data can be used to adjust the accuracy mathematically derived structural and behavioral models. Holographic Interferometry offers a powerful tool to aid in the developmental engineering of exotic metal structures for high stress applications. Advanced Titanium alloy is a significant example of these sorts of materials which has found continually increased use in advanced aerodynamic, undersea, and other highly mobil platforms. Aircraft applications in particular must consider environments where extremes in vibration and impulsive mechanical stress can affect both operation and structural stability. These considerations present ideal requisites for analysis using advanced holographic methods in the initial design and test of structures made with such advanced materials. Holographic techniques are nondestructive, real- time, and definitive in allowing the identification of

  2. Identifying contamination with advanced visualization and analysis practices: metagenomic approaches for eukaryotic genome assemblies

    Science.gov (United States)

    Delmont, Tom O.

    2016-01-01

    High-throughput sequencing provides a fast and cost-effective mean to recover genomes of organisms from all domains of life. However, adequate curation of the assembly results against potential contamination of non-target organisms requires advanced bioinformatics approaches and practices. Here, we re-analyzed the sequencing data generated for the tardigrade Hypsibius dujardini, and created a holistic display of the eukaryotic genome assembly using DNA data originating from two groups and eleven sequencing libraries. By using bacterial single-copy genes, k-mer frequencies, and coverage values of scaffolds we could identify and characterize multiple near-complete bacterial genomes from the raw assembly, and curate a 182 Mbp draft genome for H. dujardini supported by RNA-Seq data. Our results indicate that most contaminant scaffolds were assembled from Moleculo long-read libraries, and most of these contaminants have differed between library preparations. Our re-analysis shows that visualization and curation of eukaryotic genome assemblies can benefit from tools designed to address the needs of today’s microbiologists, who are constantly challenged by the difficulties associated with the identification of distinct microbial genomes in complex environmental metagenomes. PMID:27069789

  3. Development of a computer code for dynamic analysis of the primary circuit of advanced reactors

    Energy Technology Data Exchange (ETDEWEB)

    Rocha, Jussie Soares da; Lira, Carlos A.B.O.; Magalhaes, Mardson A. de Sa, E-mail: cabol@ufpe.b [Universidade Federal de Pernambuco (DEN/UFPE), Recife, PE (Brazil). Dept. de Energia Nuclear

    2011-07-01

    Currently, advanced reactors are being developed, seeking for enhanced safety, better performance and low environmental impacts. Reactor designs must follow several steps and numerous tests before a conceptual project could be certified. In this sense, computational tools become indispensable in the preparation of such projects. Thus, this study aimed at the development of a computational tool for thermal-hydraulic analysis by coupling two computer codes to evaluate the influence of transients caused by pressure variations and flow surges in the region of the primary circuit of IRIS reactor between the core and the pressurizer. For the simulation, it was used a situation of 'insurge', characterized by the entry of water in the pressurizer, due to the expansion of the refrigerant in the primary circuit. This expansion was represented by a pressure disturbance in step form, through the block 'step' of SIMULINK, thus enabling the transient startup. The results showed that the dynamic tool, obtained through the coupling of the codes, generated very satisfactory responses within model limitations, preserving the most important phenomena in the process. (author)

  4. Ion beam analysis of hydrogen in advanced materials: Recent experience of Van de Graaff lab

    Energy Technology Data Exchange (ETDEWEB)

    Kakuee, O.R.; Fathollahi, V.; Rachti, M. Lamehi [Van de Graaff Lab, Physics Research Department, Nuclear Science Research School, NSTRI, P.O. Box 14395-836, Tehran (Iran)

    2010-09-15

    Hydrogen is considered to be the ideal energy carrier in the near future. It would be of great importance to obtain experimental data regarding the interaction of hydrogen with materials as they could assist to better realize the occurring phenomena. More specifically, quantification of hydrogen in materials could help to modify the materials processing conditions in the field of hydrogen generation, storage and utilization for the final goal of energy generation. Measurement of hydrogen in materials has always been a challenge in front of researchers. In this research work, hydrogen analysis has been performed by ''Elastic Recoil Detection'' (ERD) technique using the {alpha}-beam of the Van de Graaff accelerator of Nuclear Science and Technology Research Institute (NSTRI). Capability of ERD for quantification of hydrogen in carbon nanotube, H-treated Ti thin layer as well as in semiconducting sample of Si single crystal - prepared under certain conditions - has been shown. Capability of ERD for characterization of advanced materials is shown by hydrogen quantification or hydrogen concentration depth profiling in each representative example. (author)

  5. Advancement in the chemical analysis and quality control of flavonoid in Ginkgo biloba.

    Science.gov (United States)

    Liu, Xin-Guang; Wu, Si-Qi; Li, Ping; Yang, Hua

    2015-09-10

    Flavonoids are the main active constituents in Ginkgo biloba L., which have been suggested to have broad-spectrum free-radical scavenging activities. This review summarizes the recent advances in the chemical analysis of the flavonoids in G. biloba and its finished products (from 2009 to 2014), including chemical composition, sample preparation, separation, detection and different quality criteria. More than 70 kinds of flavonoids have been identified in this plant. In this review, various analytical approaches as well as their chromatographic conditions have been described, and their advantages/disadvantages are also compared. Quantitative analyses of Ginkgo flavonoids applied by most pharmacopeias start with an acidic hydrolysis followed by determination of the resulting aglycones using HPLC. But increasing direct assay of individual flavonol glycosides found that many adulterated products were still qualified by the present tests. To obtain an authentic and applicable analytical approach for quality evaluation of Ginkgo and its finished products, related suggestions and opinions in the recent publications are mainly discussed in this review. This discussion on chemical analyses of Ginkgo flavonoids will also be found as a significant guide for widely varied natural flavonoids.

  6. Advancing effects analysis for integrated, large-scale wildfire risk assessment.

    Science.gov (United States)

    Thompson, Matthew P; Calkin, David E; Gilbertson-Day, Julie W; Ager, Alan A

    2011-08-01

    In this article, we describe the design and development of a quantitative, geospatial risk assessment tool intended to facilitate monitoring trends in wildfire risk over time and to provide information useful in prioritizing fuels treatments and mitigation measures. The research effort is designed to develop, from a strategic view, a first approximation of how both fire likelihood and intensity influence risk to social, economic, and ecological values at regional and national scales. Three main components are required to generate wildfire risk outputs: (1) burn probability maps generated from wildfire simulations, (2) spatially identified highly valued resources (HVRs), and (3) response functions that describe the effects of fire (beneficial or detrimental) on the HVR. Analyzing fire effects has to date presented a major challenge to integrated risk assessments, due to a limited understanding of the type and magnitude of changes wrought by wildfire to ecological and other nonmarket values. This work advances wildfire effects analysis, recognizing knowledge uncertainty and appropriately managing it through the use of an expert systems approach. Specifically, this work entailed consultation with 10 fire and fuels program management officials from federal agencies with fire management responsibilities in order to define quantitative resource response relationships as a function of fire intensity. Here, we demonstrate a proof-of-concept application of the wildland fire risk assessment tool, using the state of Oregon as a case study.

  7. The Advanced Spectral Library (ASTRAL): Abundance Analysis of the CP Star HR 465

    Science.gov (United States)

    Carpenter, Kenneth G.; Nielsen, Krister E.; Kober, Gladys V.

    2016-01-01

    We present the results of a spectrum analysis of the prototypical A-type magnetic CP star HR465. Synthetic spectra, using an non-LTE atmosphere model, were generated to fit high-resolution ultraviolet spectra (1200-3100 A) obtained as a part of the "Advanced Spectral Library (ASTRAL) Project: Hot Stars" program (GO-13346: Ayres PI). The ultraviolet data were supplemented by high resolution optical data recorded at the Nordic Optical Telescope with the SOFIN spectrograph. The optical data was used as a complement to the high line density ultraviolet spectrum and primarily used to derive accurate iron-group element abundances.HR 465 has previously been analyzed using IUE spectra. We revisit the object with this high quality data. Large parts of the spectrum have been synthesized with an ATLAS model (Teff=10750K, logg=4.0) and we present abundance results for more than 50 elements. We can confirm some of the abundance characteristics previously derived from IUE data, where elements heavier than Z=30 show significant abundance enhancements compared to solar values, while some of the lighter elements show abundance deficiencies. We will place these results in context of other AP stars, and the large number of element abundances will also help us to put some constraint on stellar abundance and evolution theories.

  8. Fishing on chips: up-and-coming technological advances in analysis of zebrafish and Xenopus embryos.

    Science.gov (United States)

    Zhu, Feng; Skommer, Joanna; Huang, Yushi; Akagi, Jin; Adams, Dany; Levin, Michael; Hall, Chris J; Crosier, Philip S; Wlodkowic, Donald

    2014-11-01

    Biotests performed on small vertebrate model organisms provide significant investigative advantages as compared with bioassays that employ cell lines, isolated primary cells, or tissue samples. The main advantage offered by whole-organism approaches is that the effects under study occur in the context of intact physiological milieu, with all its intercellular and multisystem interactions. The gap between the high-throughput cell-based in vitro assays and low-throughput, disproportionally expensive and ethically controversial mammal in vivo tests can be closed by small model organisms such as zebrafish or Xenopus. The optical transparency of their tissues, the ease of genetic manipulation and straightforward husbandry, explain the growing popularity of these model organisms. Nevertheless, despite the potential for miniaturization, automation and subsequent increase in throughput of experimental setups, the manipulation, dispensing and analysis of living fish and frog embryos remain labor-intensive. Recently, a new generation of miniaturized chip-based devices have been developed for zebrafish and Xenopus embryo on-chip culture and experimentation. In this work, we review the critical developments in the field of Lab-on-a-Chip devices designed to alleviate the limits of traditional platforms for studies on zebrafish and clawed frog embryo and larvae. © 2014 International Society for Advancement of Cytometry.

  9. A Modified Time Advancement Algorithm for Optimizing Channel Flow Analysis in Direct Numerical Simulation Method

    Directory of Open Access Journals (Sweden)

    E. Rajabi

    2014-01-01

    Full Text Available In this research a direct numerical simulation (DNS of turbulent flow is performed in a geometrically standard case like plane channel flow. Pseudo spectral (PS method is used due to geometry specifications and very high accuracy achieved despite relatively few grid points. A variable time-stepping algorithm is proposed which may reduce requirement of computational cost in simulation of such wall-bounded flow. Channel flow analysis is performed with both constant and varied time-step for 128 × 65×128 grid points. The time advancement is carried out by implicit third-order backward differentiation scheme for linear terms and explicit forward Euler for nonlinear convection term. PS method is used in Cartesian coordinates with Chebychev polynomial expansion in normal direction for one non-periodic boundary condition. Also Fourier series is employed in stream-wise and span-wise directions for two periodic boundary conditions. The friction Reynolds number is about Reτ=175 based on a friction velocity and channel half width. Standard common rotational form was chosen for discritization of nonlinear convective term of Navier-Stocks equation. The comparison is made between turbulent quantities such as the turbulent statistics, Reynolds stress, wall shear velocity, standard deviation of (u and total normalized energy of instantaneous velocities in both time-discretization methods. The results show that if final decision rests on economics, the proposed variable time-stepping algorithm will be proper choice which satisfies the accuracy and reduces the computational cost.

  10. Identifying contamination with advanced visualization and analysis practices: metagenomic approaches for eukaryotic genome assemblies

    Directory of Open Access Journals (Sweden)

    Tom O. Delmont

    2016-03-01

    Full Text Available High-throughput sequencing provides a fast and cost-effective mean to recover genomes of organisms from all domains of life. However, adequate curation of the assembly results against potential contamination of non-target organisms requires advanced bioinformatics approaches and practices. Here, we re-analyzed the sequencing data generated for the tardigrade Hypsibius dujardini, and created a holistic display of the eukaryotic genome assembly using DNA data originating from two groups and eleven sequencing libraries. By using bacterial single-copy genes, k-mer frequencies, and coverage values of scaffolds we could identify and characterize multiple near-complete bacterial genomes from the raw assembly, and curate a 182 Mbp draft genome for H. dujardini supported by RNA-Seq data. Our results indicate that most contaminant scaffolds were assembled from Moleculo long-read libraries, and most of these contaminants have differed between library preparations. Our re-analysis shows that visualization and curation of eukaryotic genome assemblies can benefit from tools designed to address the needs of today’s microbiologists, who are constantly challenged by the difficulties associated with the identification of distinct microbial genomes in complex environmental metagenomes.

  11. Identifying contamination with advanced visualization and analysis practices: metagenomic approaches for eukaryotic genome assemblies.

    Science.gov (United States)

    Delmont, Tom O; Eren, A Murat

    2016-01-01

    High-throughput sequencing provides a fast and cost-effective mean to recover genomes of organisms from all domains of life. However, adequate curation of the assembly results against potential contamination of non-target organisms requires advanced bioinformatics approaches and practices. Here, we re-analyzed the sequencing data generated for the tardigrade Hypsibius dujardini, and created a holistic display of the eukaryotic genome assembly using DNA data originating from two groups and eleven sequencing libraries. By using bacterial single-copy genes, k-mer frequencies, and coverage values of scaffolds we could identify and characterize multiple near-complete bacterial genomes from the raw assembly, and curate a 182 Mbp draft genome for H. dujardini supported by RNA-Seq data. Our results indicate that most contaminant scaffolds were assembled from Moleculo long-read libraries, and most of these contaminants have differed between library preparations. Our re-analysis shows that visualization and curation of eukaryotic genome assemblies can benefit from tools designed to address the needs of today's microbiologists, who are constantly challenged by the difficulties associated with the identification of distinct microbial genomes in complex environmental metagenomes.

  12. Advanced Analysis of Grid-connected PV System's Performance and Effect of Battery

    Science.gov (United States)

    Ueda, Yuzuru; Kurokawa, Kosuke; Itou, Takamitsu; Kitamura, Kiyoyuki; Akanuma, Katsumi; Yokota, Masaharu; Sugihara, Hiroyuki; Morimoto, Atsushi

    An advanced analysis method for grid connected PV systems is developed in this research. To investigate the issues which may happen in the clustered PV systems, “Demonstrative research on clustered PV systems" is being conducted from December, 2002, in Oota, Japan. More than 500 residential PV systems will be installed in the demonstrative research area, battery integrated PV systems are developed to avoid the restriction of output power due to the raising of grid voltage. Annual performance of commercial PV systems without battery is analyzed and resulted in around 80% of performance ratio on the average. Over voltage of power distribution line and snow are two major factors of very low performance ratio on daily basis. Effects of batteries are also analyzed, the results indicate that there will be some improvement for the energy loss due to the grid voltage but PCS's efficiency will be around 8% worse than that of the commercial PV systems. It is also found that the non-optimized operation of battery sometimes results in the fully-charged situation during the noontime and maximum reverse power flow may not be minimized in this situation.

  13. Analysis of transients in advanced heavy water reactor using lumped parameter models

    Energy Technology Data Exchange (ETDEWEB)

    Manmohan Pandey; Venkata Ramana Eaga; Sankar Sastry, P. [Department of Mechanical Engineering, Indian Institute of Technology Guwahati, Guwahati (India); Gupta, S.K.; Lele, H.G.; Chatterjee, B. [Reactor Safety Division, Bhabha Atomic Research Centre, Mumbai (India)

    2005-07-01

    Full text of publication follows: Analysis of transients occurring in nuclear power plants, arising from the complex interplay between core neutronics and thermal-hydraulics, is important for their operation and safety. Numerical simulations of such transients can be carried out extensively at very low computational cost by using lumped parameter mathematical models. The Advanced Heavy Water Reactor (AHWR), being developed in India, is a vertical pressure tube type reactor cooled by boiling light water under natural circulation, using thorium as fuel and heavy water as moderator. In the present work, nonlinear and linear lumped parameter dynamic models for AHWR have been developed and validated with a distributed parameter model. The nonlinear lumped model is based on point reactor kinetics equations and one-dimensional homogeneous equilibrium model of two-phase flow. The distributed model is built with RELAP5/MOD3.2 code. Various types of transients have been simulated numerically, using the lumped model as well as RELAP5. The results have been compared and parameters tuned to make the lumped model match the distributed model (RELAP5) in terms of steady state as well as dynamic behaviour. The linear model has been derived by linearizing the nonlinear model for small perturbations about the steady state. Numerical simulations of transients using the linear model have been compared with results obtained from the nonlinear model. Thus, the range of validity of the linear model has been determined. Stability characteristics of AHWR have been investigated using the lumped parameter models. (authors)

  14. Advanced technologies for genomic analysis in farm animals and its application for QTL mapping.

    Science.gov (United States)

    Hu, Xiaoxiang; Gao, Yu; Feng, Chungang; Liu, Qiuyue; Wang, Xiaobo; Du, Zhuo; Wang, Qingsong; Li, Ning

    2009-06-01

    Rapid progress in farm animal breeding has been made in the last few decades. Advanced technologies for genomic analysis in molecular genetics have led to the identification of genes or markers associated with genes that affect economic traits. Molecular markers, large-insert libraries and RH panels have been used to build the genetic linkage maps, physical maps and comparative maps in different farm animals. Moreover, EST sequencing, genome sequencing and SNPs maps are helping us to understand how genomes function in various organisms and further areas will be studied by DNA microarray technologies and proteomics methods. Because most economically important traits in farm animals are controlled by multiple genes and the environment, the main goal of genome research in farm animals is to map and characterize genes determining QTL. There are two main strategies to identify trait loci, candidate gene association tests and genome scan approaches. In recent years, some new concepts, such as RNAi, miRNA and eQTL, have been introduced into farm animal research, especially for QTL mapping and finding QTN. Several genes that influence important traits have already been identified or are close to being identified, and some of them have been applied in farm animal breeding programs by marker-assisted selection.

  15. Retrospective analysis of third-line chemotherapy in advanced non-small cell lung cancer

    Directory of Open Access Journals (Sweden)

    Ali Murat Tatli

    2015-01-01

    Results: A total of 72 patients who had received third-line or higher chemotherapy were included in the analysis. The median age of patients was 49 years (range 41-76, and there were 13 (18.1% women and 59 (81.9% men. Estimated median survival was 26 months. Moreover, overall survival was significantly longer in patients for whom disease control was achieved after second-line chemotherapy compared to those with disease progression (34 vs. 17 months, respectively. Survival after third-line treatment was significantly longer in the group with Eastern Cooperative Oncology Group (ECOG performance status 0-1 at the beginning of third-line therapy compared to patients with a status of 2-3. Conclusions: In patients with advanced stage NSCLC, administration of third-line and higher systemic chemotherapy may be associated with increase in overall survival. Furthermore, greater increases in overall survival were also observed in patients for whom disease control was achieved after second-line therapy and in those with ECOG performance status of 0-1 before third-line treatment.

  16. Advanced image analysis of the surface pattern emerging in Ni3Al intermetallic alloys on anodization

    Directory of Open Access Journals (Sweden)

    Marco Salerno

    2016-07-01

    Full Text Available Anodization of Ni3Al alloy is of interest in the field of industrial manufacturing, thanks to the formation of protective oxide layer on the materials working in corrosive environments and high temperatures. However, homogeneous surface treatment is paramount for technological applications of this material. The anodization conditions have to be set outside the ranges of corrosion and burning, which is the electric field enhanced anodic dissolution of the metal. In order to check against occurrence of these events, proper quantitative means for assessing the surface quality have to be developed and established. We approached this task by advanced analysis of scanning electron microscope images of anodized Ni3Al plates. The anodization was carried out in 0.3 M citric acid at two temperatures of 0 and 30°C and at voltages in the range of 2 12 V. Different figures can be used to characterize the quality of the surface, in terms of uniformity. Here, the concept of regularity ratio spread is used for the first time on surfaces of technological interest. Additionally, the Minkowski parameters have been calculated and their meaning is discussed.

  17. Enabling More than Moore: Accelerated Reliability Testing and Risk Analysis for Advanced Electronics Packaging

    Science.gov (United States)

    Ghaffarian, Reza; Evans, John W.

    2014-01-01

    For five decades, the semiconductor industry has distinguished itself by the rapid pace of improvement in miniaturization of electronics products-Moore's Law. Now, scaling hits a brick wall, a paradigm shift. The industry roadmaps recognized the scaling limitation and project that packaging technologies will meet further miniaturization needs or ak.a "More than Moore". This paper presents packaging technology trends and accelerated reliability testing methods currently being practiced. Then, it presents industry status on key advanced electronic packages, factors affecting accelerated solder joint reliability of area array packages, and IPC/JEDEC/Mil specifications for characterizations of assemblies under accelerated thermal and mechanical loading. Finally, it presents an examples demonstrating how Accelerated Testing and Analysis have been effectively employed in the development of complex spacecraft thereby reducing risk. Quantitative assessments necessarily involve the mathematics of probability and statistics. In addition, accelerated tests need to be designed which consider the desired risk posture and schedule for particular project. Such assessments relieve risks without imposing additional costs. and constraints that are not value added for a particular mission. Furthermore, in the course of development of complex systems, variances and defects will inevitably present themselves and require a decision concerning their disposition, necessitating quantitative assessments. In summary, this paper presents a comprehensive view point, from technology to systems, including the benefits and impact of accelerated testing in offsetting risk.

  18. Advanced image analysis of the surface pattern emerging in Ni3Al intermetallic alloys on anodization

    Science.gov (United States)

    Salerno, Marco; Stępniowski, Wojciech; Cieślak, Grzegorz; Norek, Małgorzata; Michalska-Domańska, Marta; Karczewski, Krzysztof; Chilimoniuk, Paulina; Polkowski, Wojciech; Jóźwik, Paweł; Bojar, Zbigniew

    2016-07-01

    Anodization of Ni3Al alloy is of interest in the field of industrial manufacturing, thanks to the formation of protective oxide layer on the materials working in corrosive environments and high temperatures. However, homogeneous surface treatment is paramount for technological applications of this material. The anodization conditions have to be set outside the ranges of corrosion and “burning”, which is the electric field enhanced anodic dissolution of the metal. In order to check against occurrence of these events, proper quantitative means for assessing the surface quality have to be developed and established. We approached this task by advanced analysis of scanning electron microscope images of anodized Ni3Al plates. The anodization was carried out in 0.3 M citric acid at two temperatures of 0 and 30°C and at voltages in the range of 2 12 V. Different figures can be used to characterize the quality of the surface, in terms of uniformity. Here, the concept of regularity ratio spread is used for the first time on surfaces of technological interest. Additionally, the Minkowski parameters have been calculated and their meaning is discussed.

  19. Constraining interacting dark energy models with latest cosmological observations

    CERN Document Server

    Xia, Dong-Mei

    2016-01-01

    The local measurement of $H_0$ is in tension with the prediction of $\\Lambda$CDM model based on the Planck data. This tension may imply that dark energy is strengthened in the late-time Universe. We employ the latest cosmological observations on CMB, BAO, LSS, SNe, $H(z)$ and $H_0$ to constrain several interacting dark energy models. Our results show no significant indications for the interaction between dark energy and dark matter. The $H_0$ tension can be moderately alleviated, but not totally released.

  20. Latest AMS Results on elementary particles in cosmic rays

    Science.gov (United States)

    Kounine, Andrei; AMS Collaboration

    2017-01-01

    AMS-02 is a particle physics detector collecting data on the International Space Station since May 2011. Precision measurements of all elementary charged cosmic ray particles have been performed by AMS using a data sample of 85 billion cosmic ray events collected during the first five years of operations on the Station. The latest AMS results on the fluxes and flux ratios of the elementary cosmic ray particles are presented. They show unique features that require accurate theoretical interpretation as to their origin, be it from dark matter collisions or new astrophysical sources. On behalf of the AMS Collaboration.

  1. Constraining interacting dark energy models with latest cosmological observations

    Science.gov (United States)

    Xia, Dong-Mei; Wang, Sai

    2016-11-01

    The local measurement of H0 is in tension with the prediction of Λ cold dark matter model based on the Planck data. This tension may imply that dark energy is strengthened in the late-time Universe. We employ the latest cosmological observations on cosmic microwave background, the baryon acoustic oscillation, large-scale structure, supernovae, H(z) and H0 to constrain several interacting dark energy models. Our results show no significant indications for the interaction between dark energy and dark matter. The H0 tension can be moderately alleviated, but not totally released.

  2. Latest results from the ARGO-YBJ experiment

    CERN Document Server

    Di Sciascio, Giuseppe

    2015-01-01

    The ARGO-YBJ experiment has been in stable data taking for 5 years at the YangBaJing Cosmic Ray Observatory (Tibet, P.R. China, 4300 m a.s.l., 606 g/cm$^2$). With a duty-cycle greater than 86\\% the detector collected about 5$\\times $10$^{11}$ events in a wide energy range, from few hundreds GeV up to about 10 PeV. A number of open problems in cosmic ray physics has been faced exploiting different analyses. In this paper we summarize the latest results in cosmic ray physics and in gamma-ray astronomy.

  3. Thermal Analysis of the Advanced Technology Large Aperture Space Telescope (ATLAST) 8 Meter Primary Mirror

    Science.gov (United States)

    Hornsby, Linda; Stahl, H. Philip; Hopkins, Randall C.

    2010-01-01

    The Advanced Technology Large Aperture Space Telescope (ATLAST) preliminary design concept consists of an 8 meter diameter monolithic primary mirror enclosed in an insulated, optical tube with stray light baffles and a sunshade. ATLAST will be placed in orbit about the Sun-Earth L2 and will experience constant exposure to the sun. The insulation on the optical tube and sunshade serve to cold bias the telescope which helps to minimize thermal gradients. The primary mirror will be maintained at 280K with an active thermal control system. The geometric model of the primary mirror, optical tube, sun baffles, and sunshade was developed using Thermal Desktop(R) SINDA/FLUINT(R) was used for the thermal analysis and the radiation environment was analyzed using RADCAD(R). A XX node model was executed in order to characterize the static performance and thermal stability of the mirror during maneuvers. This is important because long exposure observations, such as extra-solar terrestrial planet finding and characterization, require a very stable observatory wave front. Steady state thermal analyses served to predict mirror temperatures for several different sun angles. Transient analyses were performed in order to predict thermal time constant of the primary mirror for a 20 degree slew or 30 degree roll maneuver. This paper describes the thermal model and provides details of the geometry, thermo-optical properties, and the environment which influences the thermal performance. All assumptions that were used in the analysis are also documented. Parametric analyses are summarized for design parameters including primary mirror coatings and sunshade configuration. Estimates of mirror heater power requirements are reported. The thermal model demonstrates results for the primary mirror heated from the back side and edges using a heater system with multiple independently controlled zones.

  4. Advanced non-linear flow-induced vibration and fretting-wear analysis capabilities

    Energy Technology Data Exchange (ETDEWEB)

    Toorani, M.; Pan, L.; Li, R.; Idvorian, N. [Babcock and Wilcox Canada Ltd., Cambridge, Ontario (Canada); Vincent, B.

    2009-07-01

    Fretting wear is a potentially significant degradation mechanism in nuclear steam generators and other shell and tube heat transfer equipment as well. This paper presents an overview of the recently developed code FIVDYNA which is used for the non-linear flow-induced vibration and fretting wear analysis for operating steam generators (OTSG and RSG) and shell-and-tube heat exchangers. FIVDYNA is a non-linear time-history Flow-Induced Vibration (FIV) analysis computer program that has been developed by Babcock and Wilcox Canada to advance the understanding of tube vibration and tube to tube-support interaction. In addition to the dynamic fluid induced forces the program takes into account other tube static forces due to axial and lateral tube preload and thermal interaction loads. The program is capable of predicting the location where the fretting wear is most likely to occur and its magnitude taking into account the support geometry including gaps. FIVDYNA uses the general purpose finite element computer code ABAQUS as its solver. Using ABAQUS gives the user the flexibility to add additional forces to the tube ranging from tube preloads and the support offsets to thermal loads. The forces currently being modeled in FIVDYNA are the random turbulence, steady drag force, fluid-elastic forces, support offset and pre-strain force (axial loads). This program models the vibration of tubes and calculates the structural dynamic characteristics, and interaction forces between the tube and the tube supports. These interaction forces are then used to calculate the work rate at the support and eventually the predicted depth of wear scar on the tube. A very good agreement is found with experiments and also other computer codes. (author)

  5. Numerical Analysis of Advanced Displacement in Construction Progress of Tunnel Excavation with Weak Surrounding Rock

    Directory of Open Access Journals (Sweden)

    Qian Zhang

    2013-07-01

    Full Text Available Analysis of advanced displacement in construction progress of tunnel excavation with weak surrounding rock is carried out by numerical method and comparison of model test result. In allusion to the problems of regional landslides and extruded large-deformation seriously impacting the stability of rock mass in construction process of large-section tunnel with weak surrounding rock, the elastic-plastic numerical simulation relying on Liangshui tunnel of Lan-Yu railroad is conducted on mechanical behaviors and deformation steric effect of tunnel construction and the calculation results are compared with the modeling data. The research results show that: the steric effect of excavation face is the dominant factor in the incidence of working face and the stress of surrounding rocks gradually releases from excavation face; the range of 0.5~1 times the cave diameter around rock mass in front of working face is the disturbance range and the key area of stabilization and reinforcement for wake surrounding rock. According to the analysis and construction practice, the supporting structure of large-section tunnel with weak surrounding rock should be established as soon as possible to control the displacement change of surrounding rock in the range of load-bearing ring, reduce disturbance and improve the self-bearing capability of surrounding rock. Because of the distinct excavation steric effect of weak surrounding rock, the secondary lining structure must be established in time to bear the later pressure and restrict the large displacement of surrounding rock. The research results can provide reliable basis for engineering stability control of analogous tunnels.

  6. Astrobiology Sample Analysis Program (ASAP) for Advanced Life Detection Instrumentation Development and Calibration

    Science.gov (United States)

    Glavin, Daniel; Brinkerhoff, Will; Dworkin, Jason; Eigenbrode, Jennifer; Franz, Heather; Mahaffy, Paul; Stern, Jen; Blake, Daid; Sandford, Scott; Fries, marc; Steele, Andrew; Amashukeli, Xenia; Fisher, Anita; Grunthaner, Frank; Aubrey, Andrew; Bada, Jeff; Chiesl, Tom; Stockton, Amanda; Mathies, Rich

    2008-01-01

    Scientific ground-truth measurements for near-term Mars missions, such as the 2009 Mars Science Laboratory (MSL) mission, are essential for validating current in situ flight instrumentation and for the development of advanced instrumentation technologies for life-detection missions over the next decade. The NASA Astrobiology Institute (NAI) has recently funded a consortium of researchers called the Astrobiology Sample Analysis Program (ASAP) to analyze an identical set of homogenized martian analog materials in a "round-robin" style using both state-of-the-art laboratory techniques as well as in-situ flight instrumentation including the SAM gas chromatograph mass spectrometer and CHEMIN X-ray diffraction/fluorescence instruments on MSL and the Urey and MOMA organic analyzer instruments under development for the 2013 ExoMars missions. The analog samples studied included an Atacama Desert soil from Chile, the Murchison meteorite, a gypsum sample from the 2007 AMASE Mars analog site, jarosite from Panoche Valley, CA, a hydrothermal sample from Rio Tinto, Spain, and a "blind" sample collected during the 2007 MSL slow-motion field test in New Mexico. Each sample was distributed to the team for analysis to: (1) determine the nature and inventory of organic compounds, (2) measure the bulk carbon and nitrogen isotopic composition, (3) investigate elemental abundances, mineralogy and matrix, and (4) search for biological activity. The experimental results obtained from the ASAP Mars analog research consortium will be used to build a framework for understanding the biogeochemistry of martian analogs, help calibrate current spaceflight instrumentation, and enhance the scientific return from upcoming missions.

  7. Recent experience with multidisciplinary analysis and optimization in advanced aircraft design

    Science.gov (United States)

    Dollyhigh, Samuel M.; Sobieszczanski-Sobieski, Jaroslaw

    1990-01-01

    The task of modern aircraft design has always been complicated due to the number of intertwined technical factors from the various engineering disciplines. Furthermore, this complexity has been rapidly increasing by the development of such technologies as aeroelasticity tailored materials and structures, active control systems, integrated propulsion/airframe controls, thrust vectoring, and so on. Successful designs that achieve maximum advantage from these new technologies require a thorough understanding of the physical phenomena and the interactions among these phenomena. A study commissioned by the Aeronautical Sciences and Evaluation Board of the National Research Council has gone so far as to identify technology integration as a new discipline from which many future aeronautical advancements will arise. Regardless of whether one considers integration as a new discipline or not, it is clear to all engineers involved in aircraft design and analysis that better methods are required. In the past, designers conducted parametric studies in which a relatively small number of principal characteristics were varied to determine the effect on design requirements which were themselves often diverse and contradictory. Once a design was chosen, it then passed through the various engineers' disciplines whose principal task was to make the chosen design workable. Working in a limited design space, the discipline expert sometimes improved the concept, but more often than not, the result was in the form of a penalty to make the original concept workable. If an insurmountable problem was encountered, the process began over. Most design systems that attempt to account for disciplinary interactions have large empirical elements and reliance on past experience is a poor guide in obtaining maximum utilizations of new technologies. Further compounding the difficulty of design is that as the aeronautical sciences have matured, the discipline specialist's area of research has generally

  8. Thalidomide-based multidisciplinary treatment for patients with advanced hepatocellular carcinoma: A retrospective analysis

    Institute of Scientific and Technical Information of China (English)

    Yang-Yuan Chen; Hsu-Heng Yen; Kun-Ching Chou; Shun-Sheng Wu

    2012-01-01

    AIM: To evaluate the efficacy of thalidomide in combination with other therapies to treat patients with advanced hepatocellular carcinoma (HCC). METHODS: We performed a retrospective analysis of all patients with HCC who were treated with thalidomide for at least two months. The medical records of patients with HCC who were treated at our institution between April 2003 and March 2008 were reviewed. Image studies performed before and after treatment, tumor response, overall survival, and the decrease in α-fetoprotein (AFP) levels were evaluated. RESULTS: A total of 53 patients with HCC received either 100 or 200 mg/d of thalidomide. The patient population consisted of 9 women and 44 men with a median age of 61 years. Thirty patients (56.6%) were classified as Child-Pugh A, and 12 patients (22.6%) were classified as Child-Pugh B. Twenty-six patients had portal vein thrombosis (49.1%), and 25 patients had extrahepatic metastasis (47.1%). The median duration of thalidomide treatment was 6.0 mo. Six of the 53 patients achieved a confirmed response (11.3%), one achieved a complete response (1.9%) and 5 achieved a partial response (9.4%). The disease control rate (CR+PR+SD) was 28.3% (95% CI:17.8-42.4), and the median overall survival rate was 10.5 mo. The 1-and 2-year survival rates were 45% and 20%, respectively. Only one complete response patient showed an improved overall survival rate of 66.8 mo. Sixteen patients (30.2%) showed more than a 50% decrease in their serum AFP levels from baseline, indicating a better response rate (31.3%), disease control rate (43.8%), and overall survival time (20.7 mo). The therapy was well tolerated, and no significant toxicities were observed. CONCLUSION: Thalidomide was found to be safe for advanced HCC patients, demonstrating anti-tumor activity including response, survival, and AFP decreases of greater than 50% from baseline.

  9. Are treelines advancing? A global meta-analysis of treeline response to climate warming.

    Science.gov (United States)

    Harsch, Melanie A; Hulme, Philip E; McGlone, Matt S; Duncan, Richard P

    2009-10-01

    Treelines are temperature sensitive transition zones that are expected to respond to climate warming by advancing beyond their current position. Response to climate warming over the last century, however, has been mixed, with some treelines showing evidence of recruitment at higher altitudes and/or latitudes (advance) whereas others reveal no marked change in the upper limit of tree establishment. To explore this variation, we analysed a global dataset of 166 sites for which treeline dynamics had been recorded since 1900 AD. Advance was recorded at 52% of sites with only 1% reporting treeline recession. Treelines that experienced strong winter warming were more likely to have advanced, and treelines with a diffuse form were more likely to have advanced than those with an abrupt or krummholz form. Diffuse treelines may be more responsive to warming because they are more strongly growth limited, whereas other treeline forms may be subject to additional constraints.

  10. Deployment of an Advanced Electrocardiographic Analysis (A-ECG) to Detect Cardiovascular Risk in Career Firefighters

    Science.gov (United States)

    Dolezal, B. A.; Storer, T. W.; Abrazado, M.; Watne, R.; Schlegel, T. T.; Batalin, M.; Kaiser, W.; Smith, D. L.; Cooper, C. B.

    2011-01-01

    INTRODUCTION Sudden cardiac death is the leading cause of line of duty death among firefighters, accounting for approximately 45% of fatalities annually. Firefighters perform strenuous muscular work while wearing heavy, encapsulating personal protective equipment in high ambient temperatures, under chaotic and emotionally stressful conditions. These factors can precipitate sudden cardiac events like myocardial infarction, serious dysrhythmias, or cerebrovascular accidents in firefighters with underlying cardiovascular disease. Screening for cardiovascular risk factors is recommended but not always followed in this population. PHASER is a project charged with identifying and prioritizing risk factors in emergency responders. We have deployed an advanced ECG (A-ECG) system developed at NASA for improved sensitivity and specificity in the detection of cardiac risk. METHODS Forty-four professional firefighters were recruited to perform comprehensive baseline assessments including tests of aerobic performance and laboratory tests for fasting lipid profiles and glucose. Heart rate and conventional 12-lead ECG were obtained at rest and during incremental treadmill exercise testing (XT). In addition, a 5-min resting 12-lead A-ECG was obtained in a subset of firefighters (n=18) and transmitted over a secure networked system to a physician collaborator at NASA for advanced-ECG analysis. This A-ECG system has been proven, using myocardial perfusion and other imaging, to accurately identify a number of cardiac pathologies including coronary artery disease (CAD), left ventricular hypertrophy, hypertrophic cardiomyopathy, non-ischemic cardiomyopathy, and ischemic cardiomyopathy. RESULTS Subjects mean (SD) age was 43 (8) years, weight 91 (13) kg, and BMI of 28 (3) kg/square meter. Maximum oxygen uptake (VO2max) was 39 (9) ml/kg/min. This compares with the 45th %ile in healthy reference values and a recommended standard of 42 ml/kg/min for firefighters. The metabolic threshold (VO

  11. Extinction pattern of reef ecosystems in latest Permian

    Institute of Scientific and Technical Information of China (English)

    WU YaSheng; FAN JiaSong; JIANG HongXia; YANG Wan

    2007-01-01

    Studies of two Permian-Triassic boundary (PTB) sections on top of a Changhsingian reef in Ziyun, Guizhou Province, southwestern China indicate that the end-Permian mass extinction of reef ecosystems occurred in two steps. The first step is the extinction of all stenotropic organisms such as calcisponges and fusulinids in the latest Permian (in the Clarkina yini conodont zone). The biota after the first extinction is simple, comprising eurytropic organisms including microgastropods, ostracods, and some small burrowing organisms, or only algal mats. At the beginning of the Early Triassic (I.e. the beginning of the Hindeodus parvus zone), the environments became anoxic, and the microgastropod dominated biota or algal mats disappeared, which constituted the second episode of the mass extinction. The biota after the second extinction comprises small spherical microproblematica, some kinds of specialized organisms tolerant of anoxic or oxygen-poor conditions. As the environments became oxygenated, the specialized biota was replaced by a microgastropod-dominated simple biota. When the environmental conditions improved further, the simple biota was replaced by a diverse biota with normal-sized ammonoids, bivalves, and gastropods, representing restoration of normal oceanic conditions. Comparison with PTB sections in Dolomites, Italy and Meishan, Zhejiang Province shows that non-reef ecosystems had a similar first episode of mass extinction in the latest Permian. In the case that oceanic anoxia happened, non-reef ecosystems had a second extinction episode similar to that of reef ecosystems.

  12. System and Propagation Availability Analysis for NASA's Advanced Air Transportation Technologies

    Science.gov (United States)

    Ugweje, Okechukwu C.

    2000-01-01

    This report summarizes the research on the System and Propagation Availability Analysis for NASA's project on Advanced Air Transportation Technologies (AATT). The objectives of the project were to determine the communication systems requirements and architecture, and to investigate the effect of propagation on the transmission of space information. In this report, results from the first year investigation are presented and limitations are highlighted. To study the propagation links, an understanding of the total system architecture is necessary since the links form the major component of the overall architecture. This study was conducted by way of analysis, modeling and simulation on the system communication links. The overall goals was to develop an understanding of the space communication requirements relevant to the AATT project, and then analyze the links taking into consideration system availability under adverse atmospheric weather conditions. This project began with a preliminary study of the end-to-end system architecture by modeling a representative communication system in MATLAB SIMULINK. Based on the defining concepts, the possibility of computer modeling was determined. The investigations continue with the parametric studies of the communication system architecture. These studies were also carried out with SIMULINK modeling and simulation. After a series of modifications, two end-to-end communication links were identified as the most probable models for the communication architecture. Link budget calculations were then performed in MATHCAD and MATLAB for the identified communication scenarios. A remarkable outcome of this project is the development of a graphic user interface (GUI) program for the computation of the link budget parameters in real time. Using this program, one can interactively compute the link budget requirements after supplying a few necessary parameters. It provides a framework for the eventual automation of several computations

  13. Latest Researches Advances of Plasma Spraying: From Splat to Coating Formation

    Science.gov (United States)

    Fauchais, P.; Vardelle, M.; Goutier, S.

    2016-08-01

    The plasma spray process with solid feedstock, mainly ceramics powders, studied since the sixties is now a mature technology. The plasma jet and particle in-flight characterizations are now well established. The use of computer-aided robot trajectory allows spraying on industrial parts with complex geometries. Works about splat formation have shown the importance of: the substrate preheating over the transition temperature to get rid of adsorbates and condensates, substrate chemistry, crystal structure and substrate temperature during the whole coating process. These studies showed that coating properties strongly depend on the splat formation and layering. The first part of this work deals with a summary of conventional plasma spraying key points. The second part presents the current knowledge in plasma spraying with liquid feedstock, technology developed for about two decades with suspensions of particles below micrometers or solutions of precursors that form particles a few micrometers sized through precipitation. Coatings are finely structured and even nanostructured with properties arousing the interest of researchers. However, the technology is by far more complex than the conventional ones. The main conclusions are that models should be developed further, plasma torches and injection setups adapted, and new measuring techniques to reliably characterize these small particles must be designed.

  14. Dendrimers as a promising tool in ocular therapeutics: Latest advances and perspectives.

    Science.gov (United States)

    Rodríguez Villanueva, Javier; Navarro, Manuel Guzmán; Rodríguez Villanueva, Laura

    2016-09-10

    Dendrimers have called the attention of scientists in the area of drug and gene delivery over the last two decades for their versatility, complexity and multibranching properties. Some strategies for optimizing drug pharmacokinetics and site-specific targeting using dendrimers have been proposed. Among them, those related to treating and managing ocular diseases are of special interest. Ocular therapies suffer from significant disadvantages, including frequent administration, poor penetration and/or rapid elimination. This review provides an overview of the recent and promising progress in the dendrimers field, focusing on both the anterior and posterior segments of the eye ocular targets, the use of dendrimers as a strategy for overcoming obstacles to the traditional treatment of ocular diseases and an outlook on future directions. Finally, a first approach to ocular safety with dendrimers is intended that accounts for the state-of-the-art science to date.

  15. Latest Researches Advances of Plasma Spraying: From Splat to Coating Formation

    Science.gov (United States)

    Fauchais, P.; Vardelle, M.; Goutier, S.

    2016-12-01

    The plasma spray process with solid feedstock, mainly ceramics powders, studied since the sixties is now a mature technology. The plasma jet and particle in-flight characterizations are now well established. The use of computer-aided robot trajectory allows spraying on industrial parts with complex geometries. Works about splat formation have shown the importance of: the substrate preheating over the transition temperature to get rid of adsorbates and condensates, substrate chemistry, crystal structure and substrate temperature during the whole coating process. These studies showed that coating properties strongly depend on the splat formation and layering. The first part of this work deals with a summary of conventional plasma spraying key points. The second part presents the current knowledge in plasma spraying with liquid feedstock, technology developed for about two decades with suspensions of particles below micrometers or solutions of precursors that form particles a few micrometers sized through precipitation. Coatings are finely structured and even nanostructured with properties arousing the interest of researchers. However, the technology is by far more complex than the conventional ones. The main conclusions are that models should be developed further, plasma torches and injection setups adapted, and new measuring techniques to reliably characterize these small particles must be designed.

  16. Extending the horizons advances in computing, optimization, and decision technologies

    CERN Document Server

    Joseph, Anito; Mehrotra, Anuj; Trick, Michael

    2007-01-01

    Computer Science and Operations Research continue to have a synergistic relationship and this book represents the results of cross-fertilization between OR/MS and CS/AI. It is this interface of OR/CS that makes possible advances that could not have been achieved in isolation. Taken collectively, these articles are indicative of the state-of-the-art in the interface between OR/MS and CS/AI and of the high caliber of research being conducted by members of the INFORMS Computing Society. EXTENDING THE HORIZONS: Advances in Computing, Optimization, and Decision Technologies is a volume that presents the latest, leading research in the design and analysis of algorithms, computational optimization, heuristic search and learning, modeling languages, parallel and distributed computing, simulation, computational logic and visualization. This volume also emphasizes a variety of novel applications in the interface of CS, AI, and OR/MS.

  17. Analysis of advanced european nuclear fuel cycle scenarios including transmutation and economical estimates

    Energy Technology Data Exchange (ETDEWEB)

    Merino Rodriguez, I.; Alvarez-Velarde, F.; Martin-Fuertes, F. [CIEMAT, Avda. Complutense, 40, 28040 Madrid (Spain)

    2013-07-01

    In this work the transition from the existing Light Water Reactors (LWR) to the advanced reactors is analyzed, including Generation III+ reactors in a European framework. Four European fuel cycle scenarios involving transmutation options have been addressed. The first scenario (i.e., reference) is the current fleet using LWR technology and open fuel cycle. The second scenario assumes a full replacement of the initial fleet with Fast Reactors (FR) burning U-Pu MOX fuel. The third scenario is a modification of the second one introducing Minor Actinide (MA) transmutation in a fraction of the FR fleet. Finally, in the fourth scenario, the LWR fleet is replaced using FR with MOX fuel as well as Accelerator Driven Systems (ADS) for MA transmutation. All scenarios consider an intermediate period of GEN-III+ LWR deployment and they extend for a period of 200 years looking for equilibrium mass flows. The simulations were made using the TR-EVOL code, a tool for fuel cycle studies developed by CIEMAT. The results reveal that all scenarios are feasible according to nuclear resources demand (U and Pu). Concerning to no transmutation cases, the second scenario reduces considerably the Pu inventory in repositories compared to the reference scenario, although the MA inventory increases. The transmutation scenarios show that elimination of the LWR MA legacy requires on one hand a maximum of 33% fraction (i.e., a peak value of 26 FR units) of the FR fleet dedicated to transmutation (MA in MOX fuel, homogeneous transmutation). On the other hand a maximum number of ADS plants accounting for 5% of electricity generation are predicted in the fourth scenario (i.e., 35 ADS units). Regarding the economic analysis, the estimations show an increase of LCOE (Levelized cost of electricity) - averaged over the whole period - with respect to the reference scenario of 21% and 29% for FR and FR with transmutation scenarios respectively, and 34% for the fourth scenario. (authors)

  18. Analysis of variability, heritability, and interrelationships among grain yield and related characters in barley advanced lines

    Directory of Open Access Journals (Sweden)

    Ahmadi Jafar

    2016-01-01

    Full Text Available The main goal of this study was to improve pure lines for low input agricultural areas of the semi-arid region of Iran and similar environmental conditions. Forty barley pure lines provided from ICARDA along with three check cultivars were evaluated under rain-fed conditions in a semi-arid region of Iran during two years (2011-2013. The experiments were conducted in a randomized complete block design with four replications to estimate genetic variation and heritability for agro-morphological traits. The highest values of phenotypic and genotypic coefficients of variation were observed for the number of grains per spike followed by peduncle length, early vigor and grain yield. The broad heritability estimates ranged from 24% for grain yield to 96% for the number of grains per spike. The highest and lowest expected genetic advance, observed for days to physiological maturity and the number of grains per spike, respectively. Results of stepwise regression and path analysis showed that hectoliter grain weight and thousand grain weight exhibited the highest direct effects on grain yield, respectively. Comparisons between the pure lines and check cultivars indicated that out of 40 pure lines, 27 lines had a higher grain yield. Also, the pure lines No. 29, 13, 9 and 33 were identified as the superior lines for semi-arid environmental conditions. Our results indicate that check cultivars could be improved by selecting for pure lines with taller peduncle and the number of grains per spike, but with heavier grains. Therefore, these lines can be used as genetic material to broaden the genetic basis of barley breeding programs all over the world.

  19. Retrospective analysis of multidisciplinary therapy for locally advanced squamous cell carcinoma of the maxillary sinus

    Energy Technology Data Exchange (ETDEWEB)

    Yoshida, Hiroshi; Seo, Yuji; Nakajima, Kaori; Miyano, Takashi [Asahikawa Medical Univ., Hokkaido (Japan); Kikuchi, Yuzou [Kanazawa Univ. (Japan). School of Medicine

    2002-06-01

    The purpose of this study was to retrospectively investigate the efficacy of multidisciplinary therapy (concomitant radiotherapy and intra-arterial infusion of 5-fluorouracil (5-FU) followed by maxillectomy) in the treatment of squamous cell carcinoma of the maxillary sinus. We reviewed 71 patient records with locally advanced but respectable carcinoma of the maxillary sinus treated by means of multidisciplinary therapy between 1978 through 1997. The clinical T factor for these patients, according to the UICC definitions (1997), was 12 for T2, 46 for T3, and 13 for T4. Twelve patients were diagnosed as node-positive at initial presentation. Intra-arterial 5-FU was delivered via a superficial temporal artery in accordance with radiotherapy, and the cumulative 5-FU dose ranged from 2,900 mg to 5,250 mg (median 5,000 mg). The total radiotherapy dose ranged from 29 Gy to 48 Gy (median 48 Gy) with conventional fractionation. Patients underwent radical maxillectomy thereafter. The 5-year overall survival rate and disease-specific survival rate of all the patients were 58% and 68%, respectively. There was no significant correlation of clinical T factor or N factor with disease-specific survival on univariate and multivariate analysis. The overall treatment-related mortality rate was 3.7%. Radiation cataract later developed in all evaluable patients whose lenses were within the treatment volume. About a half of the operable T4 patients survived over 5 years by means of the above-mentioned multidisciplinary therapy. This multidisciplinary therapy should be compared to treatment with a combination of surgery and postoperative chemoradiotherapy. (author)

  20. Development of Advanced Continuum Models that Incorporate Nanomechanical Deformation into Engineering Analysis.

    Energy Technology Data Exchange (ETDEWEB)

    Zimmerman, Jonathan A.; Jones, Reese E.; Templeton, Jeremy Alan; McDowell, David L.; Mayeur, Jason R.; Tucker, Garritt J.; Bammann, Douglas J.; Gao, Huajian

    2008-09-01

    Materials with characteristic structures at nanoscale sizes exhibit significantly different mechani-cal responses from those predicted by conventional, macroscopic continuum theory. For example,nanocrystalline metals display an inverse Hall-Petch effect whereby the strength of the materialdecreases with decreasing grain size. The origin of this effect is believed to be a change in defor-mation mechanisms from dislocation motion across grains and pileup at grain boundaries at mi-croscopic grain sizes to rotation of grains and deformation within grain boundary interface regionsfor nanostructured materials. These rotational defects are represented by the mathematical conceptof disclinations. The ability to capture these effects within continuum theory, thereby connectingnanoscale materials phenomena and macroscale behavior, has eluded the research community.The goal of our project was to develop a consistent theory to model both the evolution ofdisclinations and their kinetics. Additionally, we sought to develop approaches to extract contin-uum mechanical information from nanoscale structure to verify any developed continuum theorythat includes dislocation and disclination behavior. These approaches yield engineering-scale ex-pressions to quantify elastic and inelastic deformation in all varieties of materials, even those thatpossess highly directional bonding within their molecular structures such as liquid crystals, cova-lent ceramics, polymers and biological materials. This level of accuracy is critical for engineeringdesign and thermo-mechanical analysis is performed in micro- and nanosystems. The researchproposed here innovates on how these nanoscale deformation mechanisms should be incorporatedinto a continuum mechanical formulation, and provides the foundation upon which to develop ameans for predicting the performance of advanced engineering materials.4 AcknowledgmentThe authors acknowledge helpful discussions with Farid F. Abraham, Youping Chen, Terry J

  1. Advanced Differential Radar Interferometry (A-DInSAR) as integrative tool for a structural geological analysis

    Science.gov (United States)

    Crippa, B.; Calcagni, L.; Rossi, G.; Sternai, P.

    2009-04-01

    Advanced Differential SAR interferometry (A-DInSAR) is a technique monitoring large-coverage surface deformations using a stack of interferograms generated from several complex SLC SAR images, acquired over the same target area at different times. In this work are described the results of a procedure to calculate terrain motion velocity on highly correlated pixels (E. Biescas, M. Crosetto, M. Agudo, O. Monserrat e B. Crippa: Two Radar Interferometric Approaches to Monitor Slow and Fast Land Deformation, 2007) in two area Gemona - Friuli, Northern Italy, Pollino - Calabria, Southern Italy, and, furthermore, are presented some consideration, based on successful examples of the present analysis. The choice of these pixels whose displacement velocity is calculated depends on the dispersion index value (DA) or using coherence values along the stack interferograms. A-DInSAR technique allows to obtain highly reliable velocity values of the vertical displacement. These values concern the movement of minimum surfaces of about 80m2 at the maximum resolution and the minimum velocity that can be recognized is of the order of mm/y. Because of the high versatility of the technology, because of the large dimensions of the area that can be analyzed (of about 10000Km2) and because of the high precision and reliability of the results obtained, we think it is possible to exploit radar interferometry to obtain some important information about the structural context of the studied area, otherwise very difficult to recognize. Therefore we propose radar interferometry as a valid investigation tool whose results must be considered as an important integration of the data collected in fieldworks.

  2. Chemotherapy versus support cancer treatment in advanced gastric cancer: a meta-analysis

    Directory of Open Access Journals (Sweden)

    L. Casaretto

    2006-04-01

    Full Text Available The aim of the present study was to compare the efficacy of chemotherapy and support treatment in patients with advanced non-resectable gastric cancer in a systematic review and meta-analysis of randomized clinical trials that included a comparison of chemotherapy and support care treatment in patients diagnosed with gastric adenocarcinoma, regardless of their age, gender or place of treatment. The search strategy was based on the criteria of the Cochrane Base, using the following key words: 1 randomized clinical trials and antineoplastic combined therapy or gastrointestinal neoplasm, 2 stomach neoplasm and drug therapy, 3 clinical trial and multi-modality therapy, 4 stomach neoplasm and drug therapy or quality of life, 5 double-blind method or clinical trial. The search was carried out using the Cochrane, Medline and Lilacs databases. Five studies fulfilled the inclusion criteria, for a total of 390 participants, 208 (53% receiving chemotherapy, 182 (47% receiving support care treatment and 6 losses (1.6%. The 1-year survival rate was 8% for support care and 20% for chemotherapy (RR = 2.14, 95% CI = 1.00-4.57, P = 0.05; 30% of the patients in the chemotherapy group and 12% in the support care group attained a 6-month symptom-free period (RR = 2.33, 95% CI = 1.41-3.87, P < 0.01. Quality of life evaluated after 4 months was significantly better for the chemotherapy patients (34%; RR = 2.07, 95% CI = 1.31-3.28, P < 0.01 with tumor mass reduction (RR = 3.32, 95% CI = 0.77-14.24, P = 0.1. Chemotherapy increased the 1-year survival rate of the patients and provided a longer symptom-free period of 6 months and an improvement in quality of life.

  3. Automated hotspot analysis with aerial image CD metrology for advanced logic devices

    Science.gov (United States)

    Buttgereit, Ute; Trautzsch, Thomas; Kim, Min-ho; Seo, Jung-Uk; Yoon, Young-Keun; Han, Hak-Seung; Chung, Dong Hoon; Jeon, Chan-Uk; Meyers, Gary

    2014-09-01

    Continuously shrinking designs by further extension of 193nm technology lead to a much higher probability of hotspots especially for the manufacturing of advanced logic devices. The CD of these potential hotspots needs to be precisely controlled and measured on the mask. On top of that, the feature complexity increases due to high OPC load in the logic mask design which is an additional challenge for CD metrology. Therefore the hotspot measurements have been performed on WLCD from ZEISS, which provides the benefit of reduced complexity by measuring the CD in the aerial image and qualifying the printing relevant CD. This is especially of advantage for complex 2D feature measurements. Additionally, the data preparation for CD measurement becomes more critical due to the larger amount of CD measurements and the increasing feature diversity. For the data preparation this means to identify these hotspots and mark them automatically with the correct marker required to make the feature specific CD measurement successful. Currently available methods can address generic pattern but cannot deal with the pattern diversity of the hotspots. The paper will explore a method how to overcome those limitations and to enhance the time-to-result in the marking process dramatically. For the marking process the Synopsys WLCD Output Module was utilized, which is an interface between the CATS mask data prep software and the WLCD metrology tool. It translates the CATS marking directly into an executable WLCD measurement job including CD analysis. The paper will describe the utilized method and flow for the hotspot measurement. Additionally, the achieved results on hotspot measurements utilizing this method will be presented.

  4. Therapeutic Evaluation on Advanced Pancreatic Cancer Treated by Integrative Chinese and Western Medicine Clinical Analysis of 56 Cases

    Institute of Scientific and Technical Information of China (English)

    刘鲁明; 吴良村; 林胜友; 杨维鸿; 郭勇; 徐颖扉; 舒琦瑾

    2003-01-01

    Objective: In comparison with chemotherapy, to evaluate therapeutic effcts on advanced pancreatic cancer treated by integrative Chinese and western medicine (ICWM) therapies. Methods: Based on the retrospective study of 56 patients with advanced pancreatic cancer,life table was applied to the analysis of patients' survival rate and χ2 test to the comparison of therapeutic response between ICWM and chemotherapy groups. Results: The results showed that 1-year survival rate in the ICWM group was 55.37%±3.24%; 2-year survival rate 34.61%±16.31%; 3-year survival rate 25.96%±24.64%; 5-year survival rate 25.96%±24.64%; and median survival period 16.3 months. However 1-year survival rate in the chemotherapy group was 21.95%±27.54%; 2-year survival rate 7.31%±27.54%; 3-year survival rate 0%; and median survival period 7.5 months. The therapeutic effects between two groups were significantly different (P=0.004). Further analysis suggested that the reduction of cancer mass in the ICWM group was more than that in chemotherapy group (P=0.049) and the improvement of advanced pancreatic cancer related-symptoms better than that of chemotherapy group (P=0.002). Conclusion: The ICWM comprehensive therapy is of important value in the treatment of advanced pancreatic cancer.

  5. Therapeutic Evaluation on Advanced Pancreatic Cancer Treated by Integrative Chinese and Western Medicine—Clinical Analysis of 56 Cases

    Institute of Scientific and Technical Information of China (English)

    LIULu-ming; WULiang-cun; 等

    2003-01-01

    Objective:In comparison with chemotherapy,to evaluate therapeutic effects on advanced pancreatic cancer treated by integrative Chinese and western medicine(ICWM) therapies.Methods:Based on the retrospective study of 56 patients with advanced pancreatic cancer,life table was applied to the anal-ysis of patients' survival rate and X2 test to the comparison of therapeutic response between ICWM and chemotherapy groups.Results:The results showed that 1-year survival rate 25.96%±24.64%; 5-year 37%±3.24%;2-year survival rate 34.61%±16.31%;3-year survival rate 25.96%±24.64%;5-year survival rate 25.96%±24.64%; and median survival period 16.3 months.However 1-year survival rate in the chemotherapy group was 21.95%±27.54%;2-year survival rate 7.31%±27.54%;3-year survival rate 0%; and median survival period 7.5months.The therapeutic effects between two groups were signifi-cantly different(P=0.004).Further analysis suggested that the reduction of cancer mass in the ICWM group was more than that in chemotherapy group(P=0.049) and the improvement of advanced pancreatic cancer related-symptoms better than that of chemotherapy group(P=0.002).Conclusion:The ICWM comprehensive therapy is of important value in the treatment of advanced pancreatic cancer.

  6. MorphologiCal and Cytogenetic Analysis on the Advanced Generations of Generic Hybrids between Brassica napus and Orychophragmus violaceu

    Institute of Scientific and Technical Information of China (English)

    Zhigang ZHAO; Dezhi DU; Zaiyun LI

    2012-01-01

    Objective This study aimed to reveal the genetic changes of advanced generation hybrids between Brassica napus and Orychophragmus violaceus. [Method] The morphological characteristics such as the plant shape, branching sites, leaf shape, leaf color, primary branches and secondary branches, as well as the cytolog- ical characteristics of the advanced generation hybrids (Fs-F10) between B. napus and O. violaceus were observed. [Result] The morphology analysis revealed that the hybrid progeny was more like B. rapa in leaf shape, leaf color, plant shape and ear- ly flowering phenotype, whereas more like B. napus in number of secondary branch- es, silique length and 1 000-seed weight. Analysis on the cytogenetics characteristics showed that these advanced inbred progenies were hypoploids with less than 38 chromosomes; moreover, all the chromosomes from O. violaceus had been lost. Chromosome pairings at meiotic diakinesis of hybrids between the advanced inbred progenies and B. rapa revealed that chromosomes lost in hypoploids possibly be- longed to the C genome of B. oleracea. With generations developing, chromosomes number of plants from two populations gradually increased and developed into the number of B. napus (2n=38). [Conclusion] This study will provide reference to reveal the source of chromosome lost in hypoploids and the morphological change of hybrids.

  7. Advanced analysis of complex seismic waveforms to characterize the subsurface Earth structure

    Science.gov (United States)

    Jia, Tianxia

    2011-12-01

    in seismic active zones. SPAC analysis of microtremors provides an efficient way to estimate Vs structure. Compared with other Vs estimating methods, SPAC is noninvasive and does not require any active sources, and therefore, it is especially useful in big cities. I applied SPAC method in two urban areas. The first is the historic city, Charleston, South Carolina, where high levels of seismic hazard lead to great public concern. Accurate Vs information, therefore, is critical for seismic site classification and site response studies. The second SPAC study is in Manhattan, New York City, where depths of high velocity contrast and soil-to-bedrock are different along the island. The two experiments show that Vs structure could be estimated with good accuracy using SPAC method compared with borehole and other techniques. SPAC is proved to be an effective technique for Vs estimation in urban areas. One important issue in seismology is the inversion of subsurface structures from surface recordings of seismograms. My third project focuses on solving this complex geophysical inverse problems, specifically, surface wave phase velocity dispersion curve inversion for shear wave velocity. In addition to standard linear inversion, I developed advanced inversion techniques including joint inversion using borehole data as constrains, nonlinear inversion using Monte Carlo, and Simulated Annealing algorithms. One innovative way of solving the inverse problem is to make inference from the ensemble of all acceptable models. The statistical features of the ensemble provide a better way to characterize the Earth model.

  8. The infrared imaging spectrograph (IRIS) for TMT: latest science cases and simulations

    Science.gov (United States)

    Wright, Shelley A.; Walth, Gregory; Do, Tuan; Marshall, Daniel; Larkin, James E.; Moore, Anna M.; Adamkovics, Mate; Andersen, David; Armus, Lee; Barth, Aaron; Cote, Patrick; Cooke, Jeff; Chisholm, Eric M.; Davidge, Timothy; Dunn, Jennifer S.; Dumas, Christophe; Ellerbroek, Brent L.; Ghez, Andrea M.; Hao, Lei; Hayano, Yutaka; Liu, Michael; Lopez-Rodriguez, Enrique; Lu, Jessica R.; Mao, Shude; Marois, Christian; Pandey, Shashi B.; Phillips, Andrew C.; Schoeck, Matthias; Subramaniam, Annapurni; Subramanian, Smitha; Suzuki, Ryuji; Tan, Jonathan C.; Terai, Tsuyoshi; Treu, Tommaso; Simard, Luc; Weiss, Jason L.; Wincentsen, James; Wong, Michael; Zhang, Kai

    2016-07-01

    The Thirty Meter Telescope (TMT) first light instrument IRIS (Infrared Imaging Spectrograph) will complete its preliminary design phase in 2016. The IRIS instrument design includes a near-infrared (0.85 - 2.4 micron) integral field spectrograph (IFS) and imager that are able to conduct simultaneous diffraction-limited observations behind the advanced adaptive optics system NFIRAOS. The IRIS science cases have continued to be developed and new science studies have been investigated to aid in technical performance and design requirements. In this development phase, the IRIS science team has paid particular attention to the selection of filters, gratings, sensitivities of the entire system, and science cases that will benefit from the parallel mode of the IFS and imaging camera. We present new science cases for IRIS using the latest end-to-end data simulator on the following topics: Solar System bodies, the Galactic center, active galactic nuclei (AGN), and distant gravitationally-lensed galaxies. We then briefly discuss the necessity of an advanced data management system and data reduction pipeline.

  9. Cost-efficacy analysis of hormonal treatments for advanced prostate cancer

    Directory of Open Access Journals (Sweden)

    Sergio Iannazzo

    2008-09-01

    Full Text Available Introduction: prostatic cancer is the second more frequent cancer in Italy (after lung cancer and is the third cancer-related death cause. Age is the principal risk factor and, given the ageing process undergoing in the Italian population, it seems clear that the public sanitary expenditure to treat the disease is bound to increase, arising the need to perform pharmacoeconomic evaluations of the therapeutic strategies available. Methods: we performed a cost/utility analysis, through a Markov model, of several hormonal therapies in patients with advanced prostate cancer who underwent radical prostatectomy, from the biochemical recurrence to death. Nine androgen suppression therapies were considered: orchiectomy, two nonsteroidal antiandrogens (NSAA, four luteinizing hormone-releasing hormone (LHRH agonists, cyproterone acetate and the association of a NSAA and a LHRH (BAT. In the simulation the androgen suppression therapies were started at the PSA recurrence and never stopped until death. The model used the Italian NHS prospective and a time horizon corresponding to patient’s lifetime. Drug costs were calculated for each therapy, considering the less costly brand. Results: all the considered therapies produced a life expectancy (LE of about 12 life years (LYs with a small variability ranging from 12.3 LYs for BAT (the most effective to 11.37 LYs for NSAA-flutamide (the least effective. Quality adjusted life expectancy ranged from 9.98 QALYs for BAT to 9.28 QALYs for NSAA-flutamide. The average cost per patient presented a more enhanced variability, from 12,538 Euro for orchiectomy to 59,496 Euro for NSAA-bicalutamide. Among all the alternatives orchiectomy resulted the most cost/effective alternative with a cost/utility ratio of about 1,300 Euro/QALY. In the LHRH-agonists class leuprorelin was the most cost/effective with about 2,200 Euro/QALY. A one-way sensitivity analysis showed a substantial stability of the results. Conclusions: BAT

  10. Consistency analysis for the performance of planar detector systems used in advanced radiotherapy

    Directory of Open Access Journals (Sweden)

    Kanan Jassal

    2015-03-01

    Full Text Available Purpose: To evaluate the performance linked to the consistency of a-Si EPID and ion-chamber array detectors for dose verification in advanced radiotherapy.Methods: Planar measurements were made for 250 patients using an array of ion chamber and a-Si EPID. For pre-treatment verification, the plans were generated on the phantom for re-calculation of doses. The γ-evaluation method with the criteria: dose-difference (DD ≤ 3% and distance-to-agreement (DTA ≤ 3 mm was used for the comparison of measurements. Also, the central axis (CAX doses were measured using 0.125cc ion chamber and were compared with the central chamber of array and central pixel correlated dose value from EPID image. Two types of statistical approaches were applied for the analysis. Conventional statistics used analysis of variance (ANOVA and unpaired t-test to evaluate the performance of the detectors. And statistical process control (SPC was utilized to study the statistical variation for the measured data. Control charts (CC based on an average , standard deviation ( and exponentially weighted moving averages (EWMA were prepared. The capability index (Cpm was determined as an indicator for the performance consistency of the two systems.Results: Array and EPID measurements had the average gamma pass rates as 99.9% ± 0.15% and 98.9% ± 1.06% respectively. For the point doses, the 0.125cc chamber results were within 2.1% ± 0.5% of the central chamber of the array. Similarly, CAX doses from EPID and chamber matched within 1.5% ± 0.3%. The control charts showed that both the detectors were performing optimally and all the data points were within ± 5%. EWMA charts revealed that both the detectors had a slow drift along the mean of the processes but was found well within ± 3%. Further, higher Cpm values for EPID demonstrate its higher efficiency for radiotherapy techniques.Conclusion: The performances of both the detectors were seen to be of high quality irrespective of the

  11. Advances in Computers

    CERN Document Server

    Zelkowitz, Marvin

    2010-01-01

    This is volume 79 of Advances in Computers. This series, which began publication in 1960, is the oldest continuously published anthology that chronicles the ever- changing information technology field. In these volumes we publish from 5 to 7 chapters, three times per year, that cover the latest changes to the design, development, use and implications of computer technology on society today. Covers the full breadth of innovations in hardware, software, theory, design, and applications.Many of the in-depth reviews have become standard references that co

  12. A Visual Basic simulation software tool for performance analysis of a membrane-based advanced water treatment plant.

    Science.gov (United States)

    Pal, P; Kumar, R; Srivastava, N; Chowdhury, J

    2014-02-01

    A Visual Basic simulation software (WATTPPA) has been developed to analyse the performance of an advanced wastewater treatment plant. This user-friendly and menu-driven software is based on the dynamic mathematical model for an industrial wastewater treatment scheme that integrates chemical, biological and membrane-based unit operations. The software-predicted results corroborate very well with the experimental findings as indicated in the overall correlation coefficient of the order of 0.99. The software permits pre-analysis and manipulation of input data, helps in optimization and exhibits performance of an integrated plant visually on a graphical platform. It allows quick performance analysis of the whole system as well as the individual units. The software first of its kind in its domain and in the well-known Microsoft Excel environment is likely to be very useful in successful design, optimization and operation of an advanced hybrid treatment plant for hazardous wastewater.

  13. Latest NIKA results and the NIKA-2 project

    CERN Document Server

    Monfardini, A; Adane, A; Ade, P; André, P; Beelen, A; Belier, B; Benoit, A; Bideaud, A; Billot, N; Bourrion, O; Calvo, M; Catalano, A; Coiffard, G; Comis, B; D'Addabbo, A; Désert, F -X; Doyle, S; Goupy, J; Kramer, C; Leclercq, S; Macias-Perez, J; Martino, J; Mauskopf, P; Mayet, F; Pajot, F; Pascale, E; Ponthieu, N; Revéret, V; Rodriguez, L; Savini, G; Schuster, K; Sievers, A; Tucker, C; Zylka, R

    2013-01-01

    NIKA (New IRAM KID Arrays) is a dual-band imaging instrument installed at the IRAM (Institut de RadioAstronomie Millimetrique) 30-meter telescope at Pico Veleta (Spain). Two distinct Kinetic Inductance Detectors (KID) focal planes allow the camera to simultaneously image a field-of-view of about 2 arc-min in the bands 125 to 175 GHz (150 GHz) and 200 to 280 GHz (240 GHz). The sensitivity and stability achieved during the last commissioning Run in June 2013 allows opening the instrument to general observers. We report here the latest results, in particular in terms of sensitivity, now comparable to the state-of-the-art Transition Edge Sensors (TES) bolometers, relative and absolute photometry. We describe briefly the next generation NIKA-2 instrument, selected by IRAM to occupy, from 2015, the continuum imager/polarimeter slot at the 30-m telescope.

  14. Vitiligo nonsurgical treatment: a review of latest treatment researches.

    Science.gov (United States)

    Zhang, Yanfei; Mooneyan-Ramchurn, Jessini Soranambal; Zuo, Nan; Feng, Yiguo; Xiao, Shengxiang

    2014-01-01

    Vitiligo is a common depigmenting acquired disorder affecting about 1-2% of the world population, regardless of race, ethnic background, or gender. It is characterized by the appearance of milky white maculae because of a loss of melanocytes. The disfiguring nature of vitiligo causes high psychosocial morbidity. This is especially pronounced in populations with darker skin tone, likely because of the marked contrast. A variety of nonsurgical treatment regimens are currently employed in vitiligo. We reviewed the latest studies carried out on different nonsurgical treatment modalities used in vitiligo. All nonsurgical treatment aid to repigment or depigmentation the skin, however, many of them require a prolonged treatment course and may yield minimal results as well as carry unwanted side effects. There is a need for further research into the causes of vitiligo and into discovering better treatments.

  15. The status and latest issues on KAERI export control implementation

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hyun Sook; Park, Ho Jun; Kim, Hyun Jo; Ko, Han Suk; Lee, Byung Doo [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2010-10-15

    There are four informal non-proliferation arrangements which seek to control the proliferation of weapons of mass destruction and their missile delivery systems and the transfer of conventional weapons and dual-use technologies. The four arrangements are Wassenaar Arrangement (WA) on export controls for conventional arms and dual use goods and technologies, Nuclear Supplies Group(NSG), Missile Technology Control Regime(MTCR) and Australia Group(AG) on chemical and biological weapons materials. ROK participates in four arrangements to seek to encourage responsible practice in the trade of strategic goods and technologies. It is achieved through the implementation of export control list. MKE Notification (Ministry of Knowledge Economy Notification No. 2009-250) specifies those items and technologies subject to control. In this paper, the status and latest issues on KAERI export control implementation are described

  16. The neutron decay spectrometer aSPECT: latest results

    Energy Technology Data Exchange (ETDEWEB)

    Borg, M.; Guardia, F.A.; Baessler, S.; Brito, L.C.; Glueck, F.; Heil, W.; Konrad, G.; Brito, L.C.; Horta, R.M.; Palmer, C.A.; Sobolev, Y. [Inst. fuer Physik, Univ. Mainz (Germany); Angerer, H.; Konorov, I.; Petzoldt, G.; Simson, M.; Wirth, H.F.; Zimmer, O. [Physik Dept. E18, TU Muenchen (Germany); Eberhardt, K. [Inst. fuer Kernchemie, Univ. Mainz (Germany); Rich, D. [FRM-II, TU Muenchen (Germany)

    2007-07-01

    The intention of the neutron decay spectrometer aSPECT is the measurement of the proton spectrum in the decay of free neutrons. The proton spectrum is used to deduce the value of the neutrino electron correlation coefficient a, an important experimental quantity which is useful to resolve the problem with the unitarity of the Cabbibo-Kobayashi-Maskawa Matrix. In a beam time in 2005/ 2006 at the neutron beam MEPHISTO of the research reactor ''Forschungsneutronenquelle Heinz Maier-Leibnitz'' (FRM-II), first proton spectra have been measured and several systematic tests were performed. In my talk, I will present the physical motivation and the design of our spectrometer, but mainly I will discuss our latest results and the on-going optimizations for the next beam time. (orig.)

  17. Advanced Methods for Aircraft Engine Thrust and Noise Benefits: Nozzle-Inlet Flow Analysis

    Science.gov (United States)

    Gilinsky, Mikhail; Morgan, Morris H.; Povitsky, Alex; Schkolnikov, Natalia; Njoroge, Norman; Coston, Calvin; Blankson, Isaiah M.

    2001-01-01

    The Fluid Mechanics and Acoustics Laboratory at Hampton University (HU/FM&AL) jointly with the NASA Glenn Research Center has conducted four connected subprojects under the reporting project. Basically, the HU/FM&AL Team has been involved in joint research with the purpose of theoretical explanation of experimental facts and creation of accurate numerical simulation techniques and prediction theory for solution of current problems in propulsion systems of interest to the NAVY and NASA agencies. This work is also supported by joint research between the NASA GRC and the Institute of Mechanics at Moscow State University (IM/MSU) in Russia under a CRDF grant. The research is focused on a wide regime of problems in the propulsion field as well as in experimental testing and theoretical and numerical simulation analyses for advanced aircraft and rocket engines. The FM&AL Team uses analytical methods, numerical simulations and possible experimental tests at the Hampton University campus. The fundamental idea uniting these subprojects is to use nontraditional 3D corrugated and composite nozzle and inlet designs and additional methods for exhaust jet noise reduction without essential thrust loss and even with thrust augmentation. These subprojects are: (1) Aeroperformance and acoustics of Bluebell-shaped and Telescope-shaped designs; (2) An analysis of sharp-edged nozzle exit designs for effective fuel injection into the flow stream in air-breathing engines: triangular-round, diamond-round and other nozzles; (3) Measurement technique improvement for the HU Low Speed Wind Tunnel; a new course in the field of aerodynamics, teaching and training of HU students; experimental tests of Mobius-shaped screws: research and training; (4) Supersonic inlet shape optimization. The main outcomes during this reporting period are: (l) Publications: The AIAA Paper #00-3170 was presented at the 36th AIAA/ASME/SAE/ASEE Joint Propulsion Conference, 17-19 June, 2000, Huntsville, AL. The AIAA

  18. A SWOT Analysis for Organizing a Summer School: Case Study for Advanced Summer School in Analyzing Market Data 2013

    OpenAIRE

    Radu Herman

    2013-01-01

    The economics scholars agree that investment in education is a competitive advantage. After participating and graduating the “Advanced Summer School in Analyzing Market Data 2013”, the students will gain some formal competences is applied knowledge in Statistics with the IBM SPSS Statistics software. Studies show that the employers seek also practical competences in the undergraduate students, along with the theoretical knowledge. The article focuses on a SWOT analysis for organizing a Summer...

  19. Latest Jurassic-early Cretaceous regressive facies, northeast Africa craton

    Energy Technology Data Exchange (ETDEWEB)

    van Houten, F.B.

    1980-06-01

    Nonmarine to paralic detrital deposits accumulated in six large basins between Algeria and the Arabo-Nubian shield during major regression in latest Jurassic and Early Cretaceous time. The Ghadames Sirte (north-central Libya), and Northern (Egypt) basins lay along the cratonic margin of northeastern Africa. The Murzuk, Kufra, and Southern (Egypt) basins lay in the south within the craton. Data for reconstructing distribution, facies, and thickness of relevant sequences are adequate for the three northern basins only. High detrital influx near the end of Jurassic time and in mid-Cretaceous time produced regressive nubian facies composed largely of low-sinuosity stream and fahdelta deposits. In the west and southwest the Ghadames, Murzuk, and Kufra basins were filled with a few hundred meters of detritus after long-continued earlier Mesozoic aggradation. In northern Egypt the regressive sequence succeeded earlier Mesozoic marine sedimentation; in the Sirte and Southern basins correlative deposits accumulated on Precambrian and Variscan terranes after earlier Mesozoic uplift and erosion. Waning of detrital influx into southern Tunisia and adjacent Libya in the west and into Israel in the east initiated an Albian to early Cenomanian transgression of Tethys. By late Cenomanian time it had flooded the entire cratonic margin, and spread southward into the Murzuk and Southern basins, as well as onto the Arabo-Nubian shield. Latest Jurassic-earliest Cretaceous, mid-Cretaceous, and Late Cretaceous transgressions across northeastern Africa recorded in these sequences may reflect worldwide eustatic sea-level rises. In contrast, renewed large supply of detritus during each regression and a comparable subsidence history of intracratonic and marginal basins imply regional tectonic control. 6 figures.

  20. Advancements in mass spectrometry for biological samples: Protein chemical cross-linking and metabolite analysis of plant tissues

    Energy Technology Data Exchange (ETDEWEB)

    Klein, Adam [Iowa State Univ., Ames, IA (United States)

    2015-01-01

    This thesis presents work on advancements and applications of methodology for the analysis of biological samples using mass spectrometry. Included in this work are improvements to chemical cross-linking mass spectrometry (CXMS) for the study of protein structures and mass spectrometry imaging and quantitative analysis to study plant metabolites. Applications include using matrix-assisted laser desorption/ionization-mass spectrometry imaging (MALDI-MSI) to further explore metabolic heterogeneity in plant tissues and chemical interactions at the interface between plants and pests. Additional work was focused on developing liquid chromatography-mass spectrometry (LC-MS) methods to investigate metabolites associated with plant-pest interactions.

  1. Advanced development in phytochemicals analysis of medicine and food dual purposes plants used in China (2011-2014).

    Science.gov (United States)

    Zhao, Jing; Ge, Li-Ya; Xiong, Wei; Leong, Fong; Huang, Lu-Qi; Li, Shao-Ping

    2016-01-08

    In 2011, we wrote a review for summarizing the phytochemical analysis (2006-2010) of medicine and food dual purposes plants used in China (Zhao et al., J. Chromatogr. A 1218 (2011) 7453-7475). Since then, more than 750 articles related to their phytochemical analysis have been published. Therefore, an updated review for the advanced development (2011-2014) in this topic is necessary for well understanding the quality control and health beneficial phytochemicals in these materials, as well as their research trends.

  2. Mathematical competencies and the role of mathematics in physics education: A trend analysis of TIMSS Advanced 1995 and 2008

    Directory of Open Access Journals (Sweden)

    Trude Nilsen

    2013-10-01

    Full Text Available As students advance in their learning of physics over the course of their education, the requirement of mathematical applications in physics-related tasks increases, especially so in upper secondary school and in higher education. Yet there is little empirical work (particularly large-scale or longitudinal on the application of mathematics in physics education compared with the research related to the conceptual knowledge of physics. In order to clarify the nature of mathematics in physics education, we developed a theoretical framework for mathematical competencies pertinent to various physics tasks based on theoretical frameworks from mathematics and physics education. We used this synthesis of frameworks as a basis to create a model for physics competence. The framework also served as a tool for analyzing and categorizing trend items from the international large-scale survey, TIMSS Advanced 1995 and 2008. TIMSS Advanced assessed students in upper secondary school with special preparation in advanced physics and mathematics. We then investigated the changes in achievements on these categorized items across time for nations who participated in both surveys. The results from our analysis indicate that students whose overall physics achievement declined struggled the most with items requiring mathematics, especially items requiring them to handle symbols, such as manipulating equations. This finding suggests the importance of collaboration between mathematics and physics education as well as the importance of traditional algebra for physics education.

  3. Analysis of Petroleum Technology Advances Through Applied Research by Independent Oil Producers

    Energy Technology Data Exchange (ETDEWEB)

    Brashear, Jerry P.; North, Walter B.; Thomas Charles P.; Becker, Alan B.; Faulder, David D.

    2000-01-12

    Petroleum Technology Advances Through Applied Research by Independent Oil Producers is a program of the National Oil Research Program, U.S. Department of Energy. Between 1995 and 1998, the program competitively selected and cost-shared twenty-two projects with small producers. The purpose was to involve small independent producers in testing technologies of interest to them that would advance (directly or indirectly) one or more of four national program objectives: (1) Extend the productive life of reservoirs; (2) Increase production and/or reserves; (3) Improve environmental performance; and (4) Broaden the exchange of technology information.

  4. Digital Story Analysis Utilizing the Advancing Care Excellence for Seniors Framework

    Science.gov (United States)

    Bassell, Kellie

    2013-01-01

    The purpose of this study was to explore the effectiveness of using digital storytelling as an end of rotation assignment, in a long-term care setting, for pre-licensure nursing students as a means to demonstrate an understanding of the Advancing Care Excellence for Seniors (ACES) framework. The research sought to explore the relationship between…

  5. ADVANCED ENERGY TECHNOLOGIES AND CLIMATE CHANGE: AN ANALYSIS USING THE GLOBAL CHANGE ASSESSMENT MODEL (GCAM)

    Energy Technology Data Exchange (ETDEWEB)

    Edmonds, J. A.; Wise, M. A.; MacCracken, C. N.

    1994-05-01

    We report results from a "top down" energy-economy model employing "bottom up" assumptions embedded in an integrated assessment framework, the Global Change Assessment Model (GCAM). The analys~s shows that from the perspective of long-term energy system development, differences. in results from the "top down" and "bottom up" research communities would appear to be more closely linked to differences in assumptions regarding the economic cost associated with advanced technologies than to differences In modeling approach. The adoption of assumptions regarding advanced energy technologies were shown to have a profound effect on the future rate of anthropogenic climate change. The cumulative effect of the five sets of advanced energy technologies is to reduce annual emissions from fossil fuel use to levels which stabilize atmospheric concentrations below 550 ppmv, the point at which atmospheric concentrations are double those that existed in the m~ddleo f the eighteenth century. While all energy technologies play roles in reducing future fossil fuel carbon dioxide emissions, the introduction of advanced biomass energy production technology plays a particularly important role. If biomass energy can be made available at $2.40/GJ or less in quantities sufficient to make it the core energy supply technology in the middle of the next century, then emissions can be cut dramatically relative to the reference case. The problem of emiss~ons reduction becomes one of technology development and deployment in this case, and not one of fiscal and regulatory intervention.

  6. Mobility Sensitivity Analysis for LTE-Advanced HetNet Deployments with Dual Connectivity

    DEFF Research Database (Denmark)

    Barbera, Simone; Gimenez, Lucas Chavarria; Sanchez, Maria Laura Luque

    2015-01-01

    coming from these different scenarios. The site-specific scenarios are based on detailed topography map data and advanced ray-tracing techniques. It is generally found that the first order statistics and overall conclusions are in good alignment for the considered environments. However, there are also...

  7. A standard data set for performance analysis of advanced IR image processing techniques

    NARCIS (Netherlands)

    Weiss, A.R.; Adomeit, U.; Chevalier, P.; Landeau, S.; Bijl, P.; Champagnat, F.; Dijk, J.; Göhler, B.; Landini, S.; Reynolds, J.P.; Smith, L.N.

    2012-01-01

    Modern IR cameras are increasingly equipped with built-in advanced (often non-linear) image and signal processing algorithms (like fusion, super-resolution, dynamic range compression etc.) which can tremendously influence performance characteristics. Traditional approaches to range performance model

  8. TNO ADVANCE: a modular simulation tool for combined chassis and powertrain analysis

    NARCIS (Netherlands)

    Tillaart, E. van den; Mourad, S.; Lupker, H.

    2001-01-01

    In this paper TNO-Advance is presented. It is built in a modular way, therefore allowing quick assembling of specific vehicle configurations and easy integration of new component models and future evolutions of existing models. Its entensive library is built in Matlab/Simulink, taking advantage of i

  9. Variation in Content Coverage by Classroom Composition: An Analysis of Advanced Math Course Content

    Science.gov (United States)

    Covay, Elizabeth

    2011-01-01

    Everyone knows that there is racial inequality in achievement returns from advanced math; however, they do not know why black students and white students taking the same level of math courses are not leaving with the same or comparable skill levels. To find out, the author examines variation in course coverage by the racial composition of the…

  10. 3D analysis of condylar remodelling and skeletal relapse following bilateral sagittal split advancement osteotomies

    NARCIS (Netherlands)

    Xi, T.; Schreurs, R.; Loon, B. van; Koning, M.J. de; Berge, S.J.; Hoppenreijs, T.J.; Maal, T.J.J.

    2015-01-01

    A major concern in mandibular advancement surgery using bilateral sagittal split osteotomies (BSSO) is potential postoperative relapse. Although the role of postoperative changes in condylar morphology on skeletal relapse was reported in previous studies, no study so far has objectified the precise

  11. A Qualitative Analysis of an Advanced Practice Nurse-Directed Transitional Care Model Intervention

    Science.gov (United States)

    Bradway, Christine; Trotta, Rebecca; Bixby, M. Brian; McPartland, Ellen; Wollman, M. Catherine; Kapustka, Heidi; McCauley, Kathleen; Naylor, Mary D.

    2012-01-01

    Purpose: The purpose of this study was to describe barriers and facilitators to implementing a transitional care intervention for cognitively impaired older adults and their caregivers lead by advanced practice nurses (APNs). Design and Methods: APNs implemented an evidence-based protocol to optimize transitions from hospital to home. An…

  12. Undergraduate Performance of Advanced Level and Associate Degree Students: A Comparative Analysis

    Science.gov (United States)

    St. Rose, Kieran Winnifred

    2013-01-01

    In the English-speaking Caribbean, the Advanced level qualification is the traditional and preferred route to accessing an education at the University of the West Indies (UWI). However, applicants with nontraditional qualifications--such as the associate degree qualification, teacher certificate, diploma, and mature student status (meaning one who…

  13. Devry NR447 full course latest 2015 october [ all Week Discussion and all assignments

    OpenAIRE

    Laynebaril

    2017-01-01

     Devry NR447 full course latest 2015 october [ all Week Discussion and all assignments ] Click Link Below To Buy: http://hwcampus.com/shop/nr447-full-course-latest/   Devry NR447 Week 1 Discussion 1 & 2 Latest 2015 October Discussion 1 Review the Huston (2010) article listed under reading assignments. Which skills described for the Nurse Leader in the year 2020 are important now? Explain your rationale and provide an example from your practice setting (or from y...

  14. Ionospheric Poynting Flux and Joule Heating Modeling Challenge: Latest Results and New Models.

    Science.gov (United States)

    Shim, J. S.; Rastaetter, L.; Kuznetsova, M. M.; Knipp, D. J.; Zheng, Y.; Cosgrove, R. B.; Newell, P. T.; Weimer, D. R.; Fuller-Rowell, T. J.; Wang, W.

    2014-12-01

    Poynting Flux and Joule Heating in the ionosphere - latest results from the challenge and updates at the CCMC. With the addition of satellite tracking and display features in the online analysis tool and at the Community Coordinated Modeling Center (CCMC), we are now able to obtain Poynting flux and Joule heating values from a wide variety of ionospheric models. In addition to Poynting fluxes derived from electric and magnetic field measurements from the Defense Meteorological Satellite Program (DMSP) satellites for a recent modeling challenge, we can now use a Poynting Flux model derived from FAST satellite observations for comparison. Poynting Fluxes are also correlated using Ovation Prime maps of precipitation patterns during the same time periods to assess how "typical" the events in the challenge are.

  15. Comparison of dark energy models: A perspective from the latest observational data

    CERN Document Server

    Li, Miao; Zhang, Xin

    2009-01-01

    In this paper, we compare some popular dark energy models with the assumption of a flat universe by using the latest observational data including the type Ia supernovae Constitution compilation, the baryon acoustic oscillation measurement from the Sloan Digital Sky Survey and the Two Degree Field Galaxy Redshift Survey, and the cosmic microwave background measurement given by the five-year Wilkinson Microwave Anisotropy Probe observations. Model comparison statistics such as the Bayesian and Akaike information criteria are applied to assess the worth of the models. These statistics favor models that give a good fit with fewer parameters. Based on this analysis, we find that the simplest cosmological constant model that has only one free parameter is still preferred by the current data. For other dynamical dark energy models, we find that some of them, such as the $\\alpha$ dark energy, constant $w$, generalized Chaplygin gas, and holographic dark energy models, can provide good fits to the current data, and th...

  16. Model-independent determination on $H_0$ using the latest $H(z)$ data

    CERN Document Server

    Wang, Deng

    2016-01-01

    We perform the improved constraints on the Hubble constant $H_0$ by using the model-independent method, Gaussian Processes. Utilizing the latest 36 $H(z)$ measurements, we obtain $H_0=69.21\\pm3.72$ km s$^{-1}$ Mpc$^{-1}$, which is consistent with the Planck 2015 and Riess et al. 2016 analysis at $1\\sigma$ confidence level, and reduces the uncertainty from $6.5\\%$ (Busti et al. 2014) to $5.4\\%$. Different from the results of Busti et al. 2014 by only using 19 $H(z)$ measurements, our reconstruction results of $H(z)$ and the derived values of $H_0$ are independent of the choice of covariance functions.

  17. Advanced Durability and Damage Tolerance Design and Analysis Methods for Composite Structures: Lessons Learned from NASA Technology Development Programs

    Science.gov (United States)

    Harris, Charles E.; Starnes, James H., Jr.; Shuart, Mark J.

    2003-01-01

    Aerospace vehicles are designed to be durable and damage tolerant. Durability is largely an economic life-cycle design consideration whereas damage tolerance directly addresses the structural airworthiness (safety) of the vehicle. However, both durability and damage tolerance design methodologies must address the deleterious effects of changes in material properties and the initiation and growth of microstructural damage that may occur during the service lifetime of the vehicle. Durability and damage tolerance design and certification requirements are addressed for commercial transport aircraft and NASA manned spacecraft systems. The state-of-the-art in advanced design and analysis methods is illustrated by discussing the results of several recently completed NASA technology development programs. These programs include the NASA Advanced Subsonic Technology Program demonstrating technologies for large transport aircraft and the X-33 hypersonic test vehicle demonstrating technologies for a single-stage-to-orbit space launch vehicle.

  18. Bench to batch: advances in plant cell culture for producing useful products.

    Science.gov (United States)

    Weathers, Pamela J; Towler, Melissa J; Xu, Jianfeng

    2010-02-01

    Despite significant efforts over nearly 30 years, only a few products produced by in vitro plant cultures have been commercialized. Some new advances in culture methods and metabolic biochemistry have improved the useful potential of plant cell cultures. This review will provide references to recent relevant reviews along with a critical analysis of the latest improvements in plant cell culture, co-cultures, and disposable reactors for production of small secondary product molecules, transgenic proteins, and other products. Some case studies for specific products or production systems are used to illustrate principles.

  19. Nanoscale Advances in Catalysis and Energy Applications

    Energy Technology Data Exchange (ETDEWEB)

    Li, Yimin; Somorjai, Gabor A.

    2010-05-12

    In this perspective, we present an overview of nanoscience applications in catalysis, energy conversion, and energy conservation technologies. We discuss how novel physical and chemical properties of nanomaterials can be applied and engineered to meet the advanced material requirements in the new generation of chemical and energy conversion devices. We highlight some of the latest advances in these nanotechnologies and provide an outlook at the major challenges for further developments.

  20. Latest news from the High Altitude Water Cherenkov Observatory

    Science.gov (United States)

    González Muñoz, A.; HAWC Collaboration

    2016-07-01

    The High Altitude Water Cherenkov Observatory is an air shower detector designed to study very-high-energy gamma rays (˜ 100 GeV to ˜ 100 TeV). It is located in the Pico de Orizaba National Park, Mexico, at an elevation of 4100 m. HAWC started operations since August 2013 with 111 tanks and in April of 2015 the 300 tanks array was completed. HAWC's unique capabilities, with a field of view of ˜ 2 sr and a high duty cycle of 5%, allow it to survey 2/3 of the sky every day. These features makes HAWC an excellent instrument for searching new TeV sources and for the detection of transient events, like gamma-ray bursts. Moreover, HAWC provides almost continuous monitoring of already known sources with variable gamma-ray fluxes in most of the northern and part of the southern sky. These observations will bring new information about the acceleration processes that take place in astrophysical environments. In this contribution, some of the latest scientific results of the observatory will be presented.

  1. All-sky observations with HAWC: latest results

    Science.gov (United States)

    Arteaga-Velázquez, J. C.; HAWC Collaboration

    2015-08-01

    The High Altitude Water Cherenkov (HAWC) observatory is a ground-based air- shower detector designed to study cosmic rays and gamma rays with energies from 100 GeV up to 100 TeV. HAWC simultaneously surveys 2sr of the northern sky with a high duty cycle > 90% in search for photons from point and extended sources, diffuse emission, transient events and other astrophysical phenomena at multi-TeV scales against the background of cosmic rays. In fact, the study of this background will open also the possibility of doing cosmic ray physics in the GeV — TeV regime and even to perform solar studies at HAWC. The observatory will consist of a densely packed array of 300 water Cherenkov tanks (4.5 m tall and 7.3 m diameter with 4 photomultipliers each) distributed on a 22 000 m2 surface. Deployment started in March 2012 on a plateau situated on the Sierra Negra Volcano in the state of Puebla, Mexico, at an altitude of 4100 m. Construction is expected to be finished by the first months of 2015. In the mean time, HAWC has been taking data with a partial array and preliminary results have been already obtained. In this contribution, the results from the latest HAWC observations will be presented.

  2. Latest LHCb measurements of Electroweak Boson Production in Run-1

    CERN Document Server

    CERN. Geneva

    2015-01-01

    We present the latest LHCb measurements of forward Electroweak Boson Production using proton-proton collisions recorded in LHC Run-1. The seminar shall discuss measurements of the 8 TeV W & Z boson production cross-sections. These results make use of LHCb's excellent integrated luminosity determination to provide constraints on the parton distribution functions which describe the inner structure of the proton. These LHCb measurements probe a region of phase space at low Bjorken-x where the other LHC experiments have limited sensitivity. We also present measurements of cross-section ratios, and ratios of results in 7 TeV and 8 TeV proton-proton collisions. These results provide precision tests of the Standard Model. The seminar shall also present a measurement of the forward-backward asymmetry (A_FB) in Z boson decays to two muons. This result allows for precision tests of the coupling of the Z boson to left and right handed particles, providing sensitivity to the effective weak mixing angle (...

  3. Latest trends in natural gas vehicle technology in Japan

    Energy Technology Data Exchange (ETDEWEB)

    Sato, Toshiharu [Tokyo Gas Co., Ltd. (Japan); Higashino, Koji [Osaka Gas Co., Ltd. (Japan); Usui, Akira [Toho Gas Co., Ltd. (Japan); Yamaguchi, Eiji [Saibu Gas Co., Ltd. (Japan)

    1997-11-01

    Out of the necessity for finding a solution to the air pollution and alternative fuel in Japan, the gas companies have been promoting the development and introduction of natural gas vehicles (NGVs) with the cooperation of vehicle manufacturers. The target was the development of dedicated CNG (Compressed Natural Gas) vehicles with cleaner emissions, and several types of vehicles have been achieved, from small vans to large transit buses. As at September 1996, 800 NGVs have been introduced in Japan. It is increasing steadily. They are modified from gasoline or diesel vehicles. But the vehicle manufacturers themselves are doing the modifications and much dedicated CNG vehicle technology is being included. For instance, engine combustion systems include conventional stoichiometric air fuel ratio combustion with a three-way catalyst, the lean burn system without catalyst and a combination of both using lean burn for low loads and stoichiometric ratio combustion for high loads. This report summarizes the latest trends in natural gas vehicle technology in Japan based on examples of representative types of vehicles. (au)

  4. Latest news on Arabidopsis brassinosteroid perception and signaling

    Directory of Open Access Journals (Sweden)

    Klaus eHarter

    2011-10-01

    Full Text Available Brassinosteroids (BR are plant hormones regulating growth and development. In interaction with other hormones, they are involved in environmental cue responses. The standard BR response pathway model in Arabidopsis includes the perception of the hormone by the plasma membrane receptor BRASSINOSTEROID INSENSITIVE 1 (BRI1 and its hetero-oligomerisation with the co-receptor BRI1-ASSOCIATED RECEPTOR KINASE 1 (BAK1, followed by the activation of a signaling cascade finally resulting in the expression of BR-responsive genes. Recent findings have shed new light on the molecular mechanism of BR perception, which includes the hormone-induced formation of a platform in BRI1 extracellular domain for interaction with BAK1, and on very early events of signaling at the plasma membrane-cytoplasm interface. In addition, a fast BR response pathway that modifies the membrane potential and the expansion of the cell wall – both crucial processes preceding cell elongation growth – was identified. In this review, these latest findings are summarized and discussed against the background of the standard model of BRI1-dependent signaling.

  5. Recent advance in nonlinear aeroelastic analysis and control of the aircraft

    OpenAIRE

    Xiang Jinwu; Yan Yongju; Li Daochun

    2014-01-01

    A review on the recent advance in nonlinear aeroelasticity of the aircraft is presented in this paper. The nonlinear aeroelastic problems are divided into three types based on different research objects, namely the two dimensional airfoil, the wing, and the full aircraft. Different nonlinearities encountered in aeroelastic systems are discussed firstly, where the emphases is placed on new nonlinear model to describe tested nonlinear relationship. Research techniques, especially new theoretica...

  6. Advancing smartness of traditional settlements-case analysis of Indian and Arab old cities

    Directory of Open Access Journals (Sweden)

    Mani Dhingra

    2016-12-01

    The study enlists smart urban elements in our existing old cities, which are derived from extensive literature study of Middle East cities and primary surveys of around 160 samples in a medium sized old Indian city in Rajasthan. The study assesses the baseline situation of culturally rich and varied old cities and need to advance from their inherent smartness using innovative and interactive ICT and urban engineering solutions.

  7. Trace component analysis of process hydrogen streams at the Wilsonville Advanced Coal Liquefaction Facility

    Energy Technology Data Exchange (ETDEWEB)

    Bronfenbrenner, J.C.

    1983-09-01

    This report summarizes subcontracted work done by the Radian Corporation to analyze trace components in process hydrogen streams at the Advanced Coal Liquefaction Facility in Wilsonville, Alabama. The data will be used to help define whether the gas streams to be treated in the hydrogen processing unit in the SRC-I Demonstration Plant will require further treatment to remove trace contaminants that could be explosive under certain conditions. 2 references.

  8. Cognitive predictors of skilled performance with an advanced upper limb multifunction prosthesis: a preliminary analysis.

    Science.gov (United States)

    Hancock, Laura; Correia, Stephen; Ahern, David; Barredo, Jennifer; Resnik, Linda

    2016-04-06

    Purpose The objectives were to 1) identify major cognitive domains involved in learning to use the DEKA Arm; 2) specify cognitive domain-specific skills associated with basic versus advanced users; and 3) examine whether baseline memory and executive function predicted learning. Method Sample included 35 persons with upper limb amputation. Subjects were administered a brief neuropsychological test battery prior to start of DEKA Arm training, as well as physical performance measures at the onset of, and following training. Multiple regression models controlling for age and including neuropsychological tests were developed to predict physical performance scores. Prosthetic performance scores were divided into quartiles and independent samples t-tests compared neuropsychological test scores of advanced scorers and basic scorers. Baseline neuropsychological test scores were used to predict change in scores on physical performance measures across time. Results Cognitive domains of attention and processing speed were statistically significantly related to proficiency of DEKA Arm use and predicted level of proficiency. Conclusions Results support use of neuropsychological tests to predict learning and use of a multifunctional prosthesis. Assessment of cognitive status at the outset of training may help set expectations for the duration and outcomes of treatment. Implications for Rehabilitation Cognitive domains of attention and processing speed were significantly related to level of proficiencyof an advanced multifunctional prosthesis (the DEKA Arm) after training. Results provide initial support for the use of neuropsychological tests to predict advanced learningand use of a multifunctional prosthesis in upper-limb amputees. Results suggest that assessment of patients' cognitive status at the outset of upper limb prosthetictraining may, in the future, help patients, their families and therapists set expectations for theduration and intensity of training and may help set

  9. Analysis of Advanced Fuel Assemblies and Core Designs for the Current and Next Generations of LWRs

    Energy Technology Data Exchange (ETDEWEB)

    Ragusa, Jean; Vierow, Karen

    2011-09-01

    The objective of the project is to design and analyze advanced fuel assemblies for use in current and future light water reactors and to assess their ability to reduce the inventory of transuranic elements, while preserving operational safety. The reprocessing of spent nuclear fuel can delay or avoid the need for a second geological repository in the US. Current light water reactor fuel assembly designs under investigation could reduce the plutonium inventory of reprocessed fuel. Nevertheless, these designs are not effective in stabilizing or reducing the inventory of minor actinides. In the course of this project, we developed and analyzed advanced fuel assembly designs with improved thermal transmutation capability regarding transuranic elements and especially minor actinides. These designs will be intended for use in thermal spectrum (e.g., current and future fleet of light water reactors in the US). We investigated various fuel types, namely high burn-up advanced mixed oxides and inert matrix fuels, in various geometrical designs that are compliant with the core internals of current and future light water reactors. Neutronic/thermal hydraulic effects were included. Transmutation efficiency and safety parameters were used to rank and down-select the various designs.

  10. Analysis of PV Advanced Inverter Functions and Setpoints under Time Series Simulation.

    Energy Technology Data Exchange (ETDEWEB)

    Seuss, John [Georgia Inst. of Technology, Atlanta, GA (United States); Reno, Matthew J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Broderick, Robert Joseph [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Grijalva, Santiago [Georgia Inst. of Technology, Atlanta, GA (United States)

    2016-05-01

    Utilities are increasingly concerned about the potential negative impacts distributed PV may have on the operational integrity of their distribution feeders. Some have proposed novel methods for controlling a PV system's grid - tie inverter to mitigate poten tial PV - induced problems. This report investigates the effectiveness of several of these PV advanced inverter controls on improving distribution feeder operational metrics. The controls are simulated on a large PV system interconnected at several locations within two realistic distribution feeder models. Due to the time - domain nature of the advanced inverter controls, quasi - static time series simulations are performed under one week of representative variable irradiance and load data for each feeder. A para metric study is performed on each control type to determine how well certain measurable network metrics improve as a function of the control parameters. This methodology is used to determine appropriate advanced inverter settings for each location on the f eeder and overall for any interconnection location on the feeder.

  11. Latest insights into the effects of Helicobacter pylori infection on gastric carcinogenesis

    Institute of Scientific and Technical Information of China (English)

    Kazunari Murakami; Masaaki Kodama; Toshio Fujioka

    2006-01-01

    There appears to be the strong association between Helicobacter pylori (H pylori) and gastric cancer. We reviewed the latest evidences about the effects of H pylori infection on gastric carcinogenesis, classified into epidemiology, dynamics of gastric mucosal changes,DNA damages, virulence factors, host factors, and source of gastric malignancy. Through the considerable progress made in research into virulence factors resulting from differences between H pylori strains, such as cagA positivity, as well as into host factors, such as gene polymorphisms, a diverse spectrum of H pyloriassociated diseases, including gastric cancer, is beginning to lend itself to elucidation. The impact of the novel hypothesis advanced by Houghton et al proposing bonemarrow derived stem cells (BMDC) as a potential source of gastric malignancy on evolving research remains to be seen with interest. Further progress in research into H pylori eradication as a viable prophylaxis of gastric cancer, as well as into the mechanisms of gastric carcinogenesis, is to be eagerly awaited for the current year and beyond.

  12. Perspectives on spatial data analysis

    CERN Document Server

    Rey, Sergio

    2010-01-01

    This book takes both a retrospective and prospective view of the field of spatial analysis by combining selected reprints of classic articles by Arthur Getis with current observations by leading experts in the field. Four main aspects are highlighted, dealing with spatial analysis, pattern analysis, local statistics as well as illustrative empirical applications. Researchers and students will gain an appreciation of Getis' methodological contributions to spatial analysis and the broad impact of the methods he has helped pioneer on an impressively broad array of disciplines including spatial epidemiology, demography, economics, and ecology. The volume is a compilation of high impact original contributions, as evidenced by citations, and the latest thinking on the field by leading scholars. This makes the book ideal for advanced seminars and courses in spatial analysis as well as a key resource for researchers seeking a comprehensive overview of recent advances and future directions in the field.

  13. Advanced Exergy Analysis for Chemically Reacting Systems – Application to a Simple Open Gas-Turbine System

    Directory of Open Access Journals (Sweden)

    George Tsatsaronis

    2009-09-01

    Full Text Available

    A conventional exergy analysis has some limitations, which are significantly reduced by an advanced exergy analysis. The latter evaluates: (a the interactions among components of the overall system (splitting the exergy destruction into endogenous and exogenous parts; and, (b the real potential for improving a system component (splitting the exergy destruction into unavoidable and avoidable parts. The main role of an advanced exergy analysis is to provide engineers with additional information useful for improving the design and operation of energy conversion systems. This information cannot be supplied by any other approach. In previous publications, approaches were presented that were appropriate for application to closed thermodynamic cycles, without chemical reactions (e.g., refrigeration cycles. Here a general approach is discussed that could be applied to systems with chemical reactions. Application of this approach to a simple gas-turbine system reveals the potential for improvement and the interactions among the system components.

    • This paper is an updated version of a paper published in the ECOS'08 proceedings. 

  14. Mission analysis and guidance, navigation, and control design for rendezvous and docking phase of advanced reentry vehicle mission

    Science.gov (United States)

    Strippoli, L.; Colmenarejo, P.; Strauch, H.

    2013-12-01

    Advanced Reentry Vehicle (ARV) belongs to the family of vehicles designed to perform rendezvous and docking (RvD) with the International space station (ISS) [1]. Differently from its predecessor ATV (Automated Transfer Vehicle), the ARV will transport a reentry capsule, equipped with a heatshield and able to bring back cargo, experiments, or, as a possible future development, even crew, being this latter scenario very attracting in view of the Space Shuttle retirement. GMV, as subcontractor of EADS-Astrium Germany, is in charge of the RvD and departure mission analysis and GNC (Guidance, Navigation, and Control) design of ARV mission. This paper will present the main outcomes of the study.

  15. Graph Embedding for Pattern Analysis

    CERN Document Server

    Ma, Yunqian

    2013-01-01

    Graph Embedding for Pattern Analysis covers theory methods, computation, and applications widely used in statistics, machine learning, image processing, and computer vision. This book presents the latest advances in graph embedding theories, such as nonlinear manifold graph, linearization method, graph based subspace analysis, L1 graph, hypergraph, undirected graph, and graph in vector spaces. Real-world applications of these theories are spanned broadly in dimensionality reduction, subspace learning, manifold learning, clustering, classification, and feature selection. A selective group of experts contribute to different chapters of this book which provides a comprehensive perspective of this field.

  16. Clinical Analysis of Icotinib on Beneficiary of 
Advanced Non-small Cell Lung Cancer with EGFR Common Mutation

    Directory of Open Access Journals (Sweden)

    Xiaowen JIANG

    2016-04-01

    Full Text Available Background and objective Targeted therapy has become an indispensable therapy method in advanced non-small cell lung cancer (NSCLC treatment. Epithelial growth factor receptor (EGFR tyrosine kinase inhibitor (TKI can significantly prolong the survival of patients harboring EGFR gene mutation. Icotinb is China's first EGFR-TKI with independent intellectual property rights. The aim of this study is to investigate the clinical characteristics about the beneficiary of advanced NSCLC patients with EGFR Common mutation who were treated with Icotinib. Retrospectively collect the data about beneficiary [progression-free survival (PFS≥6 months] and analysis of the related risk factors for prognosis. Methods From September 1, 2011 to September 30, 2015, 231 cases of advanced NSCLC beneficiary with EGFR common mutation were enrolled for treatment with icotinib in Zhejiang Cancer Hospital. Results The one year benefit rate was 67.9% in the group treated with Icotinib as first line, and in the groupas second line or above was 53.6%, which is statisticallysignificant. The two years benefit rate was 18.7% and 9.3%, respectively. The median PFS of first line group and the second line or above was 16.7 and 12.4 months, respectively. The presence of brain metastasis (P=0.010, Prior chemotherapy (P=0.001, Eastern Cooperative Oncology Group (ECOG score (P=0.001 were the main factors influencing the prognosis. The most common adverse were skin rashes (51 cases, 22.1% and diarrhea (27 cases, 11.7%. Conclusion Icotinib offers long-term clinical benefit and good tolerance for advanced NSCLC harboring EGFR gene mutation. Its advantage groups in addition to the patients with brain metastases and better ECOG score, the curative effect of patients with the first-line treatment is superior to second or further line.

  17. Ocean anoxia did not cause the Latest Permian Extinction

    Science.gov (United States)

    Proemse, Bernadette C.; Grasby, Stephen E.; Wieser, Michael E.; Mayer, Bernhard; Beauchamp, Benoit

    2014-05-01

    The Latest Permian Extinction (LPE, ~252 million years ago) was a turning point in the history of life on Earth with a loss of ~96% of all marine species and ~70% of all terrestrial species. While, the event undoubtedly shaped the evolution of life its cause remains enigmatic. A leading hypothesis is that the global oceans became depleted in oxygen (anoxia). In order to test this hypothesis we investigated a proxy for marine oxygen levels (molybdenum isotopic composition) in shale across the LPE horizon located on the subtropical northwest margin of Pangea at that time. We studied two sedimentary records in the Sverdrup basin, Canadian High Arctic: Buchanan Lake (eastern Axel Heiberg Island; 79° 26.1'N, 87° 12.6'W), representing a distal deep-water slope environment, and West Blind Fiord (southwest Ellesmere Island; 78° 23.9'N, 85° 57.2'W), representing a deep outer shelf environment (below storm wave base). The molybdenum isotopic composition (δ98/95Mo) of sediments has recently become a powerful tool as a paleo-oceanographic proxy of marine oxygen levels. Sample preparation was carried out in a metal-free clean room facility in the isotope laboratory of the Department of Physics and Astronomy, University of Calgary, Canada, that is supplied by HEPA-filtered air. Molybdenum isotope ratios were determined on a Thermo Scientific multi-collector inductively coupled plasma mass spectrometer (MC-ICP-MS) with an uncertainty better than ±0.10o for δ98/95Mo values. Results from the Buchanan Lake section show a large shift in δ98/95Mo values from 2.02o to +2.23o at the extinction horizon, consistent with onset of euxinic conditions. In contrast, West Blind Fiord shales, representing the sub-storm wave base shelf environment, show little change in the molybdenum isotopic composition (1.34o to +0.05), indicating ongoing oxic conditions across the LPE (Proemse et al., 2013). Our results suggest that areas of the Pangea continental shelf (North West Pangea) experienced

  18. The latest results from DICE (Detector Interferometric Calibration Experiment)

    Science.gov (United States)

    Crouzier, A.; Malbet, F.; Hénault, F.; Léger, A.; Cara, C.; Le Duigou, J. M.; Preis, O.; Kern, P.; Delboulbe, A.; Martin, G.; Feautrier, P.; Stadler, E.; Lafrasse, S.; Rochat, S.; Ketchazo, C.; Donati, M.; Doumayrou, Eric; Lagage, P. O.; Shao, M.; Goullioud, R.; Nemati, B.; Zhai, C.; Behar, E.; Potin, S.; Saint-Pe, M.; Dupont, J.

    2016-07-01

    Theia is an astrometric mission proposed to ESA in 2014 for which one of the scientific objectives is detecting Earth-like exoplanets in the habitable zone of nearby solar-type stars. This objective requires the capability to measure stellar centroids at the precision of 1x10-5 pixel. Current state-of-the-art methods for centroid estimation have reached a precision of about 3x10-5 pixel at two times Nyquist sampling, this was shown at the JPL by the VESTA experiment. A metrology system was used to calibrate intra and inter pixel quantum efficiency variations in order to correct pixelation errors. The Theia consortium is operating a testbed in vacuum in order to achieve 1x10-5 pixel precision for the centroid estimation. The goal is to provide a proof of concept for the precision requirement of the Theia spacecraft. The testbed consists of two main sub-systems. The first one produces pseudo stars: a blackbody source is fed into a large core fiber and lights-up a pinhole mask in the object plane, which is imaged by a mirror on the CCD. The second sub-system is the metrology, it projects young fringes on the CCD. The fringes are created by two single mode fibers facing the CCD and fixed on the mirror. In this paper we present the latest experiments conducted and the results obtained after a series of upgrades on the testbed was completed. The calibration system yielded the pixel positions to an accuracy estimated at 4x10-4 pixel. After including the pixel position information, an astrometric accuracy of 6 x 10-5 pixel was obtained, for a PSF motion over more than 5 pixels. In the static mode (small jitter motion of less than 1 x 10-3 pixel), a photon noise limited precision of 3x10-5 pixel was reached.

  19. Design of advanced automatic inspection system for turbine blade FPI analysis

    Science.gov (United States)

    Zheng, J.; Xie, W. F.; Viens, M.; Birglen, L.; Mantegh, I.

    2013-01-01

    Aircraft engine turbine blade is the most susceptible part to discontinuities as it works in the extremely high pressure and temperature. Among various types of NDT method, Fluorescent Penetrant Inspection (FPI) is comparably cheap and efficient thus suitable for detecting turbine blade surface discontinuities. In this paper, we have developed an Advanced Automatic Inspection System (AAIS) with Image Processing and Pattern Recognition techniques to aid human inspector. The system can automatically detect, measure and classify the discontinuities from turbine blade FPI images. The tests on the sample images provided by industrial partner have been performed to evaluate the system.

  20. Advanced Models and Algorithms for Self-Similar IP Network Traffic Simulation and Performance Analysis

    Science.gov (United States)

    Radev, Dimitar; Lokshina, Izabella

    2010-11-01

    The paper examines self-similar (or fractal) properties of real communication network traffic data over a wide range of time scales. These self-similar properties are very different from the properties of traditional models based on Poisson and Markov-modulated Poisson processes. Advanced fractal models of sequentional generators and fixed-length sequence generators, and efficient algorithms that are used to simulate self-similar behavior of IP network traffic data are developed and applied. Numerical examples are provided; and simulation results are obtained and analyzed.